An autosomal genome-wide screen for celiac disease in Bedouin families.
Celiac disease is a common, familial autoimmune disease caused by exposure to gliadin in wheat, and related prolamins in barley and rye. The prevalence of the disease is approximately 1:133. Celiac disease can cause significant morbidity. The only treatment is a gluten-free diet. A genome-wide search of 405 microsatellite markers was performed on samples from 18 Bedouin families with a minimum of two cases of celiac disease. Non-parametric and parametric (including both dominant and recessive models of inheritance) linkage analyses were performed. The most significant genome-wide linkage evidence was at chromosome 3p26 with an HLod of 3.21, under the dominant model. The only other HLod or NPL greater than 2 was at 4q35, with an HLod of 2.15 under a dominant model. The region at 3p26, previously reported in two linkage analyses, harbors interleukin receptor genes, plausible candidates for celiac disease.
Ding
Y C
YC
Department of Epidemiology, University of California Irvine, Irvine, CA 92697-7550, USA.
Weizman
Z
Z
Yerushalmi
B
B
Elbedour
K
K
Garner
C P
CP
Neuhausen
S L
SL
D018912:Arabs / Q000235:genetics*; D002446:Celiac Disease / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D005190:Family; D005799:Genes, Dominant; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats; D008957:Models, Genetic; D010375:Pedigree; D018709:Statistics, Nonparametric
D005819:Genetic Markers