title: Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia.
abstract: Among 380 Mycoplasma pneumoniae isolates from 3,678 pediatric patients with community-acquired pneumonia, 50 macrolide-resistant strains had an A2063G transition in domain V of the 23S rRNA, whereas 5 had an A2064G transition. These resistant strains increased rapidly from April 2002 to December 2006.
authors.affiliation: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minatoku, Tokyo 108-8641, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morozumi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
authors.forename: Keiko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Chiba
authors.forename: Reiko
authors.initials: R
authors.lastname: Takayanagi
authors.forename: Keita
authors.initials: K
authors.lastname: Matsubara
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakayama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects*; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy* / Q000382:microbiology; D012338:RNA, Ribosomal, 23S / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S