[Advances in the study of bioactivity and structure-function relationship of regulatory peptide AcSDKP].
As a negative regulator of hematopoiesis, AcSDKP is well known to inhibit the proliferation of hematopoietic stem cells and reported to has a biological function in non-hematopoietic cells recently. Its biological activities and structure-function relationship are reviewed in this paper.
Han
Xiang
X
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang
De-Xin
DX
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009842:Oligopeptides; C058504:goralatide