Review article: coagulation disorders in chronic liver disease.
BACKGROUND
The liver is the site for synthesis of the vast majority of proteins that play a central role in maintaining hemostasis, by participating in the regulation of coagulation and fibrinolysis.


OBJECTIVE
To summarize the available data on the impact of coagulation disorders in patients with chronic liver disease.


RESULTS
Hepatocellular damage in patients with severe liver disease can lead to abnormalities in the production and function of coagulation and fibrinolytic factors, disrupting the balance between coagulation and anticoagulation systems.


CONCLUSIONS
Hemostatic abnormalities (eg. impaired synthesis of clotting factors, heightened fibrinolysis, disseminated intravascular coagulation, thrombocytopenia, and platelet dysfunction) can increase the risk of bleeding in cirrhotic patients.
Peck-Radosavljevic
M
M
Department of Gastroenterology and Hepatology, Medizinische Universität & AKH Wien, Vienna, Austria. markus.peck@meduniwien.ac.at
D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology; D001791:Blood Platelet Disorders / Q000209:etiology* / Q000503:physiopathology; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D008107:Liver Diseases / Q000150:complications*