title: Role of leukotriene B4 receptors in rheumatoid arthritis.
abstract: The purpose of this review is to summarize the role that murine models of arthritis are playing in the understanding of human rheumatoid arthritis and how leukotriene B(4) (LTB(4)) is emerging as an important target in this field. Both the collagen-induced arthritis (CIA) model and the K/BxN serum transfer arthritis model have contributed to outline the potential mechanisms involved in inflammatory arthritis. Indeed, the CIA model has contributed to the development of effective anti-TNFalpha and anti-IL-1beta based treatments for RA that are currently in the clinic. Many recent studies in mouse models have suggested a critical role for LTB(4) and its receptors in the development of inflammatory arthritis. Inhibitors of LTB(4) biosynthesis as well as LTB(4) receptors are protective in mouse models of RA and mice deficient in the LTB(4) biosynthetic enzymes or LTB(4) receptors are resistant to disease development suggesting several promising targets for RA in this pathway.
authors.affiliation: Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville Health Sciences, Louisville, KY 40202, United States; Departments of Microbiology and Immunology, University of Louisville Health Sciences, Louisville, KY 40202, United States.
authors.forename: Steven
authors.initials: S
authors.lastname: Mathis
authors.affiliation: Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville Health Sciences, Louisville, KY 40202, United States; Departments of Microbiology and Immunology, University of Louisville Health Sciences, Louisville, KY 40202, United States.
authors.forename: Venkatakrishna R
authors.initials: VR
authors.lastname: Jala
authors.affiliation: Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville Health Sciences, Louisville, KY 40202, United States; Departments of Microbiology and Immunology, University of Louisville Health Sciences, Louisville, KY 40202, United States. Electronic address: H0bodd01@gwise.louisville.edu.
authors.forename: Bodduluri
authors.initials: B
authors.lastname: Haribabu
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D007975:Leukotriene B4 / Q000378:metabolism; D018102:Receptors, Leukotriene B4 / Q000276:immunology / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4