Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors.
BACKGROUND
Serologic markers have been proposed for monitoring hepatic fibrosis in chronic liver disease. Among fibrosis markers, type III procollagen (PIIIP) and hyaluronic acid have been studied in these patients.


OBJECTIVE
To evaluate the association between these serum markers with histological findings.


METHODS
A prospective cross-sectional study was carried out with HCV-positive blood donors. The studied population included men and women whose age ranged from 18 to 60 years, with elevated liver function tests [ALT levels > 1.5 times the normal value and alterations of two or more of the following: any changes in the levels of ALT, aspartate aminotransferase, conjugated bilirrubin, gammaglobulin, gammaglutamyltranspeptidase, albumin, platelet count; alkaline phosphatase levels >1.5 times the normal value, or prothrombin time below 70% and above 60%]. Fourty-nine patients were submitted to liver biopsy, blood analysis of PIIIP, hyaluronic acid, besides liver function tests.


RESULTS
Liver function tests were not associated with tissular fibrosis, as assessed by ALT (>1.5 times above normal, fibrosis risk=18.8%; <1.5 times, 11.8%). Elevated PIIIP was correlated with 66.7% chance of fibrosis, whereas normal levels, 9.3%. Hyaluronic acid, when elevated, gave a chance of 33.3% of fibrosis; when normal, 12.5%.


CONCLUSIONS
There was no association between liver function tests, hyaluronic acid and fibrosis. However, PIIIP was related with liver fibrosis. Maybe, this marker should be useful to assess fibrosis in patients with chronic hepatitis C.
Camacho
Vera Regina Rodrigues
VR
Program in Gastroenterology, Federal University of Rio Grande do Sul, Porto Alegre, RS. lhccamacho@terra.com.br
Silveira
Themis Reverbel da
TR
Oliveira
Jarbas Rodrigues de
JR
Barros
Sérgio Gabriel Silva de
SG
Cerski
Carlos Thadeu Schmidt
CT
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D024061:Collagen Type III / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006526:Hepatitis C / Q000097:blood* / Q000473:pathology / Q000821:virology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index
D015415:Biomarkers; D024061:Collagen Type III; D006820:Hyaluronic Acid