title: ImmunoCell-Array: a novel technology for pathway discovery and cell profiling.
abstract: A major challenge in drug discovery is the definition of the activity of therapeutic compounds before they enter clinical trials. Currently, many tools are available to profile drug response at a multiparametric level. Furthermore, the novel discipline of systems biology is offering interpretative cues to the amount of data generated by the so-called omics technologies. Nonetheless, novel approaches are needed to comprehensively evaluate drug response. This review will describe a recent technology for protein profiling, the ImmunoCell-Array, which, in to the authors' opinion, can enter the scenario of profiling technologies with the goal of offering a comprehensive description of proteome dynamics in a cellular context.
authors.affiliation: IFOM-IEO Campus, Via Adamello, 16-20139 Milan, Italy. luca.giorgetti@ifom-ieo-campus.it
authors.forename: Luca
authors.initials: L
authors.lastname: Giorgetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Zanardi
authors.forename: Samuele
authors.initials: S
authors.lastname: Venturini
authors.forename: Roberta
authors.initials: R
authors.lastname: Carbone
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling / Q000191:economics / Q000379:methods*; D006801:Humans; D007118:Immunoassay / Q000191:economics / Q000379:methods*; D020543:Proteome / Q000032:analysis*; D046888:Tissue Array Analysis / Q000191:economics / Q000379:methods*
chemical_list: D020543:Proteome