[Influence of desoxycorticosterone on the response of calf coronary artery strips to adrenaline].
The effect of desoxycorticosterone on the adrenaline-induced relaxation of coronary arteries was studied "in vitro". It resulted that the effect of adrenaline was enhanced by desoxycorticosterone. It is concluded that desoxycorticosterone potentiates the effects of adrenaline by inhibiting its inactivation by Catechol-O-methyltransferase.
Bettini
V
V
Istituto di Fisiologia Umana dell'Università di Padova.
Legrenzi
E
E
Lovato
A
A
Mayellaro
F
F
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008901:Mineralocorticoids / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D008901:Mineralocorticoids; D014662:Vasoconstrictor Agents; D003900:Desoxycorticosterone; D004837:Epinephrine