title: Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
abstract: YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a variety of adverse effects on cell signaling leading to suppression of cytokine expression and induction of programmed cell death. A comparative in vitro study with Y. pestis and Y. enterocolitica O:8 virulent strains shows some critical disparity in YopJ/YopP-related effects on immune cells. Involvement of yopJ in virulence was evaluated in mouse model of bubonic plague.
authors.affiliation: Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Zauberman
authors.forename: Baruch
authors.initials: B
authors.lastname: Velan
authors.forename: Emanuelle
authors.initials: E
authors.lastname: Mamroud
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Flashner
authors.forename: Avigdor
authors.initials: A
authors.lastname: Shafferman
authors.forename: Sara
authors.initials: S
authors.lastname: Cohen
mesh_terms: D017209:Apoptosis; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D005798:Genes, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D013045:Species Specificity; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D015008:Yersinia enterocolitica / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D015010:Yersinia pestis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C109227:YopP protein, Yersinia