[A role of fatty acids in the development of oxidative stress in aging. A hypothesis].
Elevated contents of fatty acids predominantly of the palmitic acid in the extracellular medium is the cause of the triglyceride accumulation in nonadipose tissues that is followed by hyperglycemia, lipotoxicity, glucosotoxicity and the development of oxidative stress. These symptoms characterize hypodynamic and hyperphagia states and aging. It is supposed that the chronic augmentation of the free fatty acid's level in blood that starts immediately after the body growing stops is a consequence of the impairment in fat homeostasis and is associated with the leptin resistance. Hypodinamic and hyperphagia make this age associated tendency more evident.
Tereshin
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D000375:Aging / Q000378:metabolism*; D005227:Fatty Acids / Q000633:toxicity*; D006801:Humans; D018384:Oxidative Stress; D019308:Palmitic Acid / Q000633:toxicity*; D014280:Triglycerides / Q000378:metabolism*
D005227:Fatty Acids; D014280:Triglycerides; D019308:Palmitic Acid