title: Estimation of the strength of adhesion between a thermoresponsive polymer coating and nitinol wire.
abstract: As polymer coatings become more widely used in the biomedical device industry, both to improve biocompatibility and as coatings for localised drug delivery, quantitative methods to measure the adhesive strength between coatings and substrates become a very important consideration. The aim of this study was to take a method for estimating the interfacial fracture toughness of a film to a flat substrate and apply it to Nitinol wires used in the production of medical devices. An investigation into the affect of surface roughness on the fracture toughness was also conducted. For the present study, a thermoresponsive based Poly (N-isopropylacrylamide) polymer was coated onto nitinol wire substrates and the adhesion strength between the polymer and wire was measured using a nanoindentation technique. Different surface treated nitinol wires, with different surface topography and roughness were used, and the affect of these surface properties on adhesion strength was investigated. Results showed that it was possible to apply the delamination technique to wire samples and obtain fracture toughness values. Results also showed that the surface roughness is an important parameter that can affect the adhesion between a coating and the substrate. It was found that, as the average surface roughness increased so also did the adhesive strength between the coating and wire sample.
authors.affiliation: National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland, mairtin.deburca@gmail.com
authors.forename: Martin
authors.initials: M
authors.lastname: Burke
authors.forename: Brenda
authors.initials: B
authors.lastname: Clarke
authors.forename: Yuri
authors.initials: Y
authors.lastname: Rochev
authors.forename: Alexandar
authors.initials: A
authors.lastname: Gorelov
authors.forename: William
authors.initials: W
authors.lastname: Carroll
mesh_terms: D000268:Adhesiveness; D000497:Alloys / Q000737:chemistry*; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D016503:Drug Delivery Systems; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011108:Polymers; C013616:nitinol