Copper-catalyzed regiospecific synthesis of N-alkylbenzimidazoles.
A copper-catalyzed method is described for the preparation of N-alkylbenzimidazoles in regioisomerically pure form starting from o-haloanilines. The method utilizing CuI and trans-N,N'-dimethyl-1,2-cyclohexanediamine allows the preparation of N-alkylbenzimidazoles in good to excellent yields.
Zheng
Nan
N
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Buchwald
Stephen L
SL
D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
D000588:Amines; D001562:Benzimidazoles; D010165:Palladium; D003300:Copper