Reversal of fortune: Rad5 to the rescue.
In a recent issue of Molecular Cell, Blastyák et al. (2007) show that the yeast Rad5 protein can promote error-free template switching and replication past a DNA lesion via a novel DNA unwinding reaction that also pairs nascent and parental strands.
Klein
Hannah L
HL
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA. hannah.klein@med.nyu.edu
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004265:DNA Helicases; D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D004271:DNA, Fungal; C112520:MMS2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C471610:UBC13 protein, S cerevisiae; D044763:Ubiquitin-Conjugating Enzymes; D044767:Ubiquitin-Protein Ligases; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I; D000251:Adenosine Triphosphatases; C076225:RAD5 protein, S cerevisiae; D004265:DNA Helicases