CD147 immunoglobulin superfamily receptor function and role in pathology.
The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced.
Iacono
Kathryn T
KT
University of Pennsylvania, Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th & Hamilton Walk, Philadelphia, PA 19104-6082, USA.
Brown
Amy L
AL
Greene
Mark I
MI
Saouaf
Sandra J
SJ
D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D051926:Basigin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051242:Caveolin 1 / Q000378:metabolism; D021983:Cyclophilins / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D000860:Hypoxia; D016023:Integrins / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D008214:Lymphocytes / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D051242:Caveolin 1; D016023:Integrins; D027501:Monocarboxylic Acid Transporters; D051926:Basigin; D020782:Matrix Metalloproteinases; D021983:Cyclophilins