Localization and trafficking of cardiac voltage-gated potassium channels.
The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve modulators of channel synthesis and assembly, post-translational processing, various molecular motors and an increasing number of modifying enzymes and molecular anchors. The roles of anchoring proteins, molecular motors and kinases are explored and recent findings on channel internalization and trafficking are presented.
Steele
D F
DF
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.
Zadeh
A Dehghani
AD
Loewen
M E
ME
Fedida
D
D
D000818:Animals; D015640:Ion Channel Gating; D020409:Molecular Motor Proteins / Q000502:physiology; D010766:Phosphorylation; D015221:Potassium Channels / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport
D020409:Molecular Motor Proteins; D015221:Potassium Channels