High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice.
This experiment examined dopamine D2 receptor and its transporter (DAT) density in mice fed a high-fat or low-fat diet for twenty days as well as fed twenty days of high-fat diet then changed to low-fat diet for one and seven days. Quantitative autoradiography revealed that twenty days of high-fat diet consumption significantly increased D2 receptor and decreased DAT density in the dorsal and ventral parts of the caudal caudate putamen (D2: 32% and 35% respectively, DAT: 33.3% and 28.8% respectively) compared with low-fat diet. High-fat feeding also increased D2 binding in the nucleus accumbens shell (36%). D2 receptor and DAT density remained unchanged following reversal of the diets from high-fat to low-fat diet. The high-fat diet induced increase of D2 receptor and decrease of DAT binding may have occurred due to defensive control over dopaminergic activity in response to a positive energy balance.
South
Timothy
T
Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia.
Huang
Xu-Feng
XF
D000818:Animals; D001345:Autoradiography; D004032:Diet; D004041:Dietary Fats / Q000633:toxicity*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D020738:Leptin / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D011699:Putamen / Q000187:drug effects / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis*
D004041:Dietary Fats; D050483:Dopamine Plasma Membrane Transport Proteins; D020738:Leptin; D017448:Receptors, Dopamine D2