title: Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.
abstract: A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.
authors.affiliation: Department of Chemistry, Karnatak University's Karnatak Science College, College Road, Dharwad 580001, Karnataka, India.
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Kalkhambkar
authors.forename: Geeta M
authors.initials: GM
authors.lastname: Kulkarni
authors.forename: Chandrappa M
authors.initials: CM
authors.lastname: Kamanavalli
authors.forename: N
authors.initials: N
authors.lastname: Premkumar
authors.forename: S M B
authors.initials: SM
authors.lastname: Asdaq
authors.forename: Chung Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D005461:Fluorine / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy; D051379:Mice
chemical_list: D000700:Analgesics; D001372:Aza Compounds; D003374:Coumarins; D005461:Fluorine; C030123:coumarin