[Recent advance in research on immunomodulatory function of mesenchymal stem cells].
Mesenchymal stem cells (MSCs) are a kind of adult stem cells which have the capability to differentiate into multiple cell types as well as self-renew continuously. Recent studies demonstrate that MSCs are low immunogenic and able to exert immunomodulatory function by various approaches, such as suppression of the lymphocyte proliferation, reduction of the dentritic cell generation, maturation and function, down-regulation of the CTL formation and enhancement of regulatory T-cell proportion. In vivo experiments show that MSC infusion can prolong the survival time of allo-skin graft in baboon and ameliorate experimental autoimmune encephalomyelitis in mice. Successful reports have been documented about clinical application of MSC in the management of graft-versus-host disease. In this review, the immunological characteristics and the immunomodulation functions in vitro and in vivo of MSC were summarized.
Li
Hong
H
Department of Cell Biology, Institute of Basic Medical Sciences Academy of Military Medical Sciences, Beijing 100850, China.
Guo
Zi-Kuan
ZK
Mao
Ning
N
D000818:Animals; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000276:immunology* / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology