title: Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein.
abstract: Dr. Haifan Lin is professor of Cell Biology at Yale University, where he studies the mechanism of stem cell self-renewal in fruit flies, mice, and human cancer cells. Recently named director of the Yale Stem Cell Center, Dr. Lin has made seminal contributions to the stem cell field, most notably his demonstration of the stem cell niche theory using the fruit fly model, his discovery of the PIWI/AGO gene family that is essential for stem cell division in diverse organisms, and his recent finding of a group of small RNAs called PIWI-interacting, or piRNAs, which may play a crucial role in stem cell proliferation and germline development. Dr. Lin's work on piRNAs was recognized by Science Magazine as a top scientific breakthrough of 2006. Recently, the Lin lab has begun exploring the role of these molecules in stem cell division and oncogenesis.
authors.forename: Haifan
authors.initials: H
authors.lastname: Lin
mesh_terms: D000818:Animals; D060565:Argonaute Proteins; D001695:Biology / Q000266:history*; D049109:Cell Proliferation; D003237:Connecticut; D004330:Drosophila; D029721:Drosophila Proteins; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D035683:MicroRNAs / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D034743:RNA-Induced Silencing Complex; D012109:Research Support as Topic; D033581:Stem Cell Transplantation / Q000208:ethnology / Q000639:trends; D013234:Stem Cells / Q000502:physiology*
chemical_list: D060565:Argonaute Proteins; D029721:Drosophila Proteins; D035683:MicroRNAs; D011506:Proteins; D034743:RNA-Induced Silencing Complex; C116498:piwi protein, Drosophila