[CD4+ guided interruption HAART in HIV patients].
We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+ > 500/microl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact, during the follow-up period there were no deaths, nor opportunistic infections. Reintroduction of HAART was due to: CD4+ fall under 200/microl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated with a short period of treatment interruption.
Antolini
Dario
D
Unità Operativa di Malattie Infettive, Dipartimento di Patologia Generale, Ospedale Policlinico G.B. Rossi, Verona.
Lanzafame
Massimiliano
M
Lattuada
Emanuela
E
Vento
Sandro
S
Concia
Ercole
E
D000208:Acute Disease; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000276:immunology; D013921:Thrombocytopenia / Q000276:immunology; D013997:Time Factors; D019562:Viral Load