title: Changes in heart rate variability may reflect sympatholysis during spinal anaesthesia.
abstract: BACKGROUND
  To investigate if changes in low-to-high frequency ratio (LF/HF), low frequency (LF) and high frequency (HF) heart rate variability reflect autonomic regulation during spinal anaesthesia (SA) in pregnant women scheduled for elective Caesarean section.
  
  
  METHODS
  Prospective clinical trial. Systolic blood pressure (SBP) and heart rate variability were analysed at baseline, 5 min after SA and 15 min after SA. Patients were assigned by baseline LF/HF. Group LF/HF < 2.5 (n= 52) was compared to group LF/HF > 2.5 (n= 48). Non-parametric tests for statistical analysis.
  
  
  RESULTS
  Group LF/HF > 2.5 showed a significant decrease in LF/HF and LF as well as an increase in HF during SA (median, range): baseline LF/HF [4.0 (3.2/4.8)] decreased to 2.3 (1.3/3.4) at event 15 min after SA (P < 0.001). Baseline LF = 59(43/71)% decreased to 40 (27/55)% at event 15 min after SA (P < 0.05). Baseline HF = 15(13/22)% increased to 26(15/41)% at event 15 min after SA (P < 0.05). In contrast, group LF/HF < 2.5 demonstrated only moderate changes in LF/HF, LF and HF during SA. SBP decreased significantly in group LF/HF > 2.5 (median and range) lowest SBP group LF/HF > 2.5: 80 (50/127 mmHg vs. group LF/HF < 2.5: 109 (104/142) mmHg, P < 0.001. Decrease of SBP before and after SA was correlated with a decrease in LF/HF, LF, and HF, respectively: LF/HF - SBP: r= 0.30, r(2)= 0.09, P < 0.001; LF - SBP: r= 0.25, r(2)= 0.06, P < 0.05, HF, NS.
  
  
  CONCLUSIONS
  Changes in heart rate variability parameters in the course of SA may reflect a decrease in sympathetic activity and relative increase in parasympathetic activity as a result of the block. In the course of SA, the more pronounced the changes in heart rate variability were the more distinct the hypotension.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. hanss@anesthesie.uni-kiel.de
authors.forename: R
authors.initials: R
authors.lastname: Hanss
authors.forename: H
authors.initials: H
authors.lastname: Ohnesorge
authors.forename: M
authors.initials: M
authors.lastname: Kaufmann
authors.forename: R
authors.initials: R
authors.lastname: Gaupp
authors.forename: T
authors.initials: T
authors.lastname: Ledowski
authors.forename: M
authors.initials: M
authors.lastname: Steinfath
authors.forename: J
authors.initials: J
authors.lastname: Scholz
authors.forename: B
authors.initials: B
authors.lastname: Bein
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D013565:Sympatholytics / Q000494:pharmacology*
chemical_list: D013565:Sympatholytics