A minimal model for glycemia control in critically ill patients.
In this paper we propose a modified minimal model to be used for glycemia control in critically ill patients. For various reasons the Bergman minimal model is widely used to describe glucose and insulin dynamics. However, since this model is mostly valid in a rather restrictive setting, it might not be suitable to be used in a model predictive controller. Simulations show that the new model exhibits a similar glycemia behaviour but clinically more realistic insulin kinetics. Therefore it is potentially more suitable for glycemia control. The designed model is also estimated on a set of critically ill patients giving promising results.
Van Herpe
Tom
T
Katholieke Universiteit Leuven, Belgium.
Pluymers
Bert
B
Espinoza
Marcelo
M
Van den Berghe
Greet
G
De Moor
Bart
B
D000368:Aged; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D016638:Critical Illness; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005951:Glucose Tolerance Test / Q000295:instrumentation*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015203:Reproducibility of Results
D001786:Blood Glucose; D007328:Insulin