title: Primary and secondary anosognosia for memory impairment in patients with Alzheimer's disease.
abstract: The neuropsychology of anosognosia for memory impairment in Alzheimer's disease (AD) was examined in 92 AD patients and 92 case matched individuals for comparison, using three quantitative methods of assessment: Experimenter Rating Scale (ERS), Objective Judgement Discrepancy (OJD) and Subjective-Rating Discrepancy (SRD). The OJD showed significant domain specific correlations with memory functioning as well as a significant correlation with susceptibility to intrusional errors. Memory or executive dysfunction may affect the immediate ability to judge cognitive performance in a domain specific manner (secondary anosognosia). Longer-term awareness of cognitive deficit appears less influenced by impaired basic cognitive functions, than by the decline of metacognitive function (primary anosognosia).
authors.affiliation: Division of Psychiatry, Landspitali University Hospital, Reykjavik, Iceland. khannesd@landspitali.is
authors.forename: Kristin
authors.initials: K
authors.lastname: Hannesdottir
authors.forename: Robin G
authors.initials: RG
authors.lastname: Morris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008569:Memory Disorders / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012649:Self Concept; D012647:Self-Assessment; D018709:Statistics, Nonparametric