HIV-associated Kaposi sarcoma: pathogenesis and therapy.
While classical Kaposi sarcoma is a slowly progressing tumor, AIDS-related Kaposi sarcoma is much more aggressive. After introduction of antiretroviral therapy and with the use of well- tolerated chemotherapeutic agents, complete remission of the tumor can be achieved. Local therapeutic options include excision, cryosurgery, radiation and alitretinoin gel. In 45 % of patients with more than 400/microl CD4+ lymphocytes, interferon-alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis.
Potthoff
Anja
A
Department of Dermatology and Allergy, St. Josef Hospital, Ruhr-University Bochum, Germany.
Brockmeyer
Norbert H
NH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D019288:Herpesvirus 8, Human / Q000472:pathogenicity; D006801:Humans; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014774:Virulence
D019380:Anti-HIV Agents