Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis.
Skin findings in childhood sarcoidosis vary greatly, but only a few occurrences have been published in which the histopathology has been characterized well. We describe a child with sarcoidosis in whom the cutaneous findings were atypical, resembling granuloma annulare. Histologic examination of these cutaneous lesions, however, revealed areas of sarcoid-like epithelioid cell granulomas, a palisading granulomatous process with features of granuloma annulare, as well as palisading neutrophilic and granulomatous dermatitis and interstitial granulomatous dermatitis. This underscores the variability of skin findings in childhood sarcoidosis--even within the same patient--and suggests that sarcoidosis should be considered in the differential diagnosis of children initially diagnosed with granulomatous skin lesions, such as granuloma annulare, palisading neutrophilic, and granulomatous dermatitis or interstitial granulomatous dermatitis, who demonstrate associated signs of systemic disease.
Kwon
Eun J
EJ
School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hivnor
Chad M
CM
Yan
Albert C
AC
Forbes
Brian
B
Elenitsas
Rosalie
R
Albert
Dan
D
Pawel
Bruce
B
Honig
Paul
P
Pessler
Frank
F
D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000473:pathology; D005260:Female; D016460:Granuloma Annulare / Q000473:pathology*; D006801:Humans; D012507:Sarcoidosis / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*