title: Bacteriocin-like inhibitory substances from Campylobacter spp.
abstract: Twenty-five Campylobacter isolates were screened for production of antimicrobial substances using a deferred antagonism assay. Sixteen isolates showed activity against either Staphylococcus aureus, Salmonella enterica serovar Enteritidis or Candida albicans. The inhibitory activity was sensitive to treatment with pronase E, trypsin and pepsin, suggesting that the antimicrobial compound(s) are proteinaceous. Activity spectra of isolates included S. aureus, Micrococcus luteus, Streptococcus sp., Bacillus subtilis, a drug-resistant clinical isolate of S. aureus and one isolate of C. albicans. Producing isolates showed cross-immunity and inhibitory activity was only observed on solid media. The findings of this study suggest that Campylobacter produces proteinaceous inhibitory substances.
authors.affiliation: Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados. sworkman@uwichill.edu.bb
authors.forename: Suzanne Nicole
authors.initials: SN
authors.lastname: Workman
authors.forename: Floyd E
authors.initials: FE
authors.lastname: Been
authors.forename: Simera R
authors.initials: SR
authors.lastname: Crawford
authors.forename: Marc C
authors.initials: MC
authors.lastname: Lavoie
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D000898:Antibiosis; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D002167:Campylobacter / Q000378:metabolism* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins