Live immunisation against Theileria parva: containing or spreading the disease?
Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al. have examined the persistence of vaccine strains in immunised cattle using polymorphic genomic markers. They confirm that elements of the vaccine establish a carrier state in vaccinated animals and present evidence that alleles associated with vaccine strains emerge in co-grazing non-vaccinated cattle. However, the epidemiological impact of these observations might be tempered by extensive recombination of co-ingested strains in the tick vector.
McKeever
Declan J
DJ
Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK. dmckeever@rvc.ac.uk
D000818:Animals; D002417:Cattle; D014644:Genetic Variation; D016052:Protozoan Vaccines / Q000276:immunology*; D016797:Theileria parva / Q000235:genetics* / Q000276:immunology*; D013801:Theileriasis / Q000517:prevention & control* / Q000635:transmission; D013987:Ticks / Q000469:parasitology; D014613:Vaccines, Attenuated
D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated