Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.
A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.
Kalkhambkar
Rajesh G
RG
Department of Chemistry, Karnatak University's Karnatak Science College, College Road, Dharwad 580001, Karnataka, India.
Kulkarni
Geeta M
GM
Kamanavalli
Chandrappa M
CM
Premkumar
N
N
Asdaq
S M B
SM
Sun
Chung Ming
CM
D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D005461:Fluorine / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy; D051379:Mice
D000700:Analgesics; D001372:Aza Compounds; D003374:Coumarins; D005461:Fluorine; C030123:coumarin