Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.
Abe
Kazumichi
K
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Nguyen
Kim Phung
KP
Fine
Sean D
SD
Mo
Ji-Hun
JH
Shen
Carol
C
Shenouda
Steve
S
Corr
Maripat
M
Jung
Steffen
S
Lee
Jongdae
J
Eckmann
Lars
L
Raz
Eyal
E
D000208:Acute Disease; D019264:Adoptive Transfer; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D004167:Diphtheria Toxin / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D004334:Drug Administration Schedule; D018836:Inflammation Mediators / Q000378:metabolism; D016899:Interferon-beta / Q000494:pharmacology; D016753:Interleukin-10 / Q000494:pharmacology; D008024:Ligands; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D016896:Treatment Outcome
D016207:Cytokines; D004167:Diphtheria Toxin; D018836:Inflammation Mediators; D008024:Ligands; D011994:Recombinant Proteins; D051217:Toll-Like Receptor 9; D016753:Interleukin-10; D016899:Interferon-beta; D016264:Dextran Sulfate