title: Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
abstract: More than 20 years ago, hantaviral antigens were reported in tissues of the Eurasian common shrew (Sorex araneus), Eurasian water shrew (Neomys fodiens) and common mole (Talpa europea), suggesting that insectivores, or soricomorphs, might serve as reservoirs of unique hantaviruses. Using RT-PCR, sequences of a genetically distinct hantavirus, designated Seewis virus (SWSV), were amplified from lung tissue of a Eurasian common shrew, captured in October 2006 in Graubünden, Switzerland. Pair-wise analysis of the full-length S and partial M and L segments of SWSV indicated approximately 55%-72% similarity with hantaviruses harbored by Murinae, Arvicolinae, Neotominae and Sigmodontinae rodents. Phylogenetically, SWSV grouped with other recently identified shrew-borne hantaviruses. Intensified efforts are underway to clarify the genetic diversity of SWSV throughout the geographic range of the Eurasian common shrew, as well as to determine its relevance to human health.
authors.affiliation: Department of Microbiology, College of Medicine, and Institute for Viral Diseases, Korea University, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Korea. jwsong@korea.ac.kr
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
authors.forename: Se Hun
authors.initials: SH
authors.lastname: Gu
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Bennett
authors.forename: Satoru
authors.initials: S
authors.lastname: Arai
authors.forename: Maria
authors.initials: M
authors.lastname: Puorger
authors.forename: Monika
authors.initials: M
authors.lastname: Hilbe
authors.forename: Richard
authors.initials: R
authors.lastname: Yanagihara
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000662:veterinary* / Q000821:virology; D008168:Lung / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012788:Shrews / Q000821:virology*