Testosterone and behavior: involvement of the hormone in psychotropic effects of baclofen.
We studied the effect of baclofen (GABA(B) receptor agonist) on the behavior of male mice with different levels of anxiety in tests for social and sexual contact and on blood testosterone levels. The drug reduced testosterone level and behavioral reaction to an unknown male in intact animals and did not modulate the hormone level and social contacts in anxious mice. In the test with receptive female, baclofen reduced testosterone level and sexual motivation in intact males and did not modulate the hormone level and initial sexual interest in anxious mice. Parallelism in the development of behavioral and endocrine components of the reaction to social and sexual stimuli confirms possible involvement of testosterone in psychotropic effects of baclofen.
Amikishieva
A V
AV
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. amik@bionet.nsc.ru
D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012919:Social Behavior; D013739:Testosterone / Q000097:blood*
D018755:GABA Agonists; D013739:Testosterone; D001418:Baclofen