title: Outcome of large hemispheric infarcts: an experience of 50 patients in Taiwan.
abstract: BACKGROUND
  Large hemispheric infarcts cause high mortality and morbidity. Understanding the clinical course and prognostic factors in patients with LHI, thereby enabling the identification of patients who will benefit from early aggressive intervention, is important. This study describes the clinical course of patients who had LHI and identifies the predictors for mortality.
  
  
  METHODS
  A retrospective collection of clinical and laboratory data in patients admitted to a neurologic intensive care unit of a medical center was examined. Large hemispheric infarct was defined as an infarct that involved at least 2 of the 3 (deep, superior, and posterior) MCA territories. Patients who received a hemicraniectomy were not included.
  
  
  RESULTS
  Fifty patients with radiologically confirmed LHI were analyzed. The 30-day mortality rate was 22%. Only patients who had massive infarcts (complete MCA territory infarcts and beyond) died, whereas none with i-MCAs died (P < .001). For the 26 patients with massive infarcts, the 30-day mortality was 42.3%. Early deterioration, ipsilateral pupil dilation, and a low GCS were associated with mortality. Further analysis revealed that an age less than 70 years (OR 24.5, 95% CI 2.3-262.6) and a GCS less than 10 at the second day of stroke (OR 15, 95% CI 1.5-149.5) predicted a fatal outcome among patients with massive infarcts. A GCS less than 12 at the first day of stroke and early CT findings of hypodensity more than one half of the MCA territory were associated with massive infarct.
  
  
  CONCLUSIONS
  The extent of infarction is a crucial factor for mortality. The consciousness level may identify patients at risk for massive infarct at the first day of stroke and predict a fatal outcome as early as the second day. Early identification of the extent of infarction and close monitoring of the consciousness level help predict outcome.
authors.affiliation: Department of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan.
authors.forename: Wei-Hung
authors.initials: WH
authors.lastname: Chen
authors.forename: Chyi-Huey
authors.initials: CH
authors.lastname: Bai
authors.forename: Sheng-Jean
authors.initials: SJ
authors.lastname: Huang
authors.forename: Hou-Chang
authors.initials: HC
authors.lastname: Chiu
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Lien
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D054022:Cerebrum / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology*; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology*; D009026:Mortality; D015878:Mydriasis / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D014057:Tomography, X-Ray Computed