[Gerontology in silico: the emergence of a new discipline].
In this paper the modern views concerning the place of mathematical and computer modeling of aging and aging related pathologies in the current state and in future developments of gerontology are discussed. The review of most perspective directions of research including analyses of demographic, molecular, cellular, and physiological mechanisms of aging, the roles of damage and reparation of DNA, cell proliferation and apoptosis, where application of mathematical modeling is promising is given. Special attention is paid to the results and perspectives of mathematical modeling in experimental gerontology including modeling of aging and longevity in laboratory animals (nematode worms, fruit flies, mice, rats) and humans.
Iashin
A I
AI
Romaniukha
A A
AA
Mikhal'skiĭ
A I
AI
Novosel'tsev
V N
VN
Ukraintsev
S V
SV
Khaliavkin
A V
AV
Anisimov
V N
VN
D000818:Animals; D003198:Computer Simulation; D005853:Geriatrics / Q000379:methods*; D006801:Humans; D008297:Male; D051379:Mice; D008954:Models, Biological; D051381:Rats