title: Dendritic cells break bonds to tolerize.
abstract: Typically, dendritic cells (DCs) induce peripheral tolerance under steady state but immunity during inflammation or infection. In this issue of Immunity, Jiang et al. (2007) identify disruption of E-cadherin interactions as a unique maturation pathway by which DCs are capable of mediating tolerance.
authors.affiliation: Institute of Experimental Immunology, CH 8091 Zurich, Switzerland. maries@van-den.broek.ch
authors.forename: Maries
authors.initials: M
authors.lastname: van den Broek
mesh_terms: D000818:Animals; D015820:Cadherins / Q000276:immunology / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D017634:Self Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D015820:Cadherins