title: New clearance evaluation method for hepatological diagnostics.
abstract: Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient.
authors.affiliation: Institute of Chemical Technology, Department of Mathematics, Prague, Czech Republic.
authors.forename: J A
authors.initials: JA
authors.lastname: Tichý
authors.forename: M
authors.initials: M
authors.lastname: Loucka
authors.forename: Z M
authors.initials: ZM
authors.lastname: Trefný
authors.forename: M
authors.initials: M
authors.lastname: Hojerová
authors.forename: J
authors.initials: J
authors.lastname: Svacinka
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Friedrichová
mesh_terms: D000328:Adult; D000368:Aged; D001825:Body Fluid Compartments; D002302:Cardiac Output; D004396:Coloring Agents / Q000493:pharmacokinetics; D003720:Densitometry / Q000379:methods* / Q000592:standards; D005234:Fatty Liver / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008111:Liver Function Tests / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017711:Nonlinear Dynamics; D012044:Regression Analysis; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green