A multidrug-resistant (MDR) HIV type 1 infection in a homosexual man and identified source patient.
We report a case (IC) of multidrug-resistant (MDR) HIV-1 infection in which the identification of the source patient (S) was supported by phylogenetic analysis of the pol gene and by the similarity of env sequences. HIV isolates from IC and S were characterized as non-syncytium viruses: a X4 variant (R(11) E(26)) was identified in both cases according to the V3 loop sequence. The pol mutational profile of IC included multiple protease and reverse-transcriptase inhibitor mutations similar to those in S. The lamivudine/tenofovir/tipranavir/ritonavir/enfuvirtide association was effective for IC but not for S.
Monno
Laura
L
Clinic of Infectious Diseases, University of Bari, Bari, Italy. l.monno@clininf.uniba.it
Punzi
Grazia
G
Brindicci
Gaetano
G
Lagioia
Antonella
A
Ladisa
Nicoletta
N
Saracino
Annalisa
A
Ingletti
Maria
M
Angarano
Gioacchino
G
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral; D015752:Genes, env; D015751:Genes, pol; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006716:Homosexuality; D006801:Humans; D008297:Male; D009154:Mutation; D010802:Phylogeny; D019562:Viral Load
D019380:Anti-HIV Agents