title: Impact of variation in acute virulence of BVDV1 strains on design of better vaccine efficacy challenge models.
abstract: Due to antigenic differences between BVDV1 and BVDV2 strains, both pestivirus species are included in U.S. vaccines. The efficacy of these vaccines in preventing acute infections is evaluated based on reduction of clinical disease. While high virulence BVDV2 strains are used in U.S. vaccine efficacy studies, the BVDV1 strain used (NY-1) produces very little in the way of clinical disease. In order to identify a BVDV1 strain that generates a more pronounced clinical presentation, three field strains were compared to NY-1. Infection with two of the field strains resulted in significantly more pronounced clinical disease compared to NY-1. Decreasing the inoculation of a field strain by two logs did not significantly change clinical presentation.
authors.affiliation: Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, P.O. Box 70, Ames, IA 50010, USA. jridpath@nadc.ars.usda.gov
authors.forename: Julia F
authors.initials: JF
authors.lastname: Ridpath
authors.forename: John D
authors.initials: JD
authors.lastname: Neill
authors.forename: Ernst
authors.initials: E
authors.lastname: Peterhans
mesh_terms: D000208:Acute Disease; D000818:Animals; D001831:Body Temperature; D002417:Cattle; D002460:Cell Line; D030241:Diarrhea Virus 1, Bovine Viral / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity*; D018655:Lymphocyte Count; D018448:Models, Immunological; D018182:Pestivirus Infections / Q000276:immunology / Q000821:virology; D010976:Platelet Count; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence; D014779:Virus Replication
chemical_list: D014765:Viral Vaccines