Nitric oxide, ischaemia and brain inflammation.
Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors.
Murphy
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University of Washington School of Medicine, Seattle, WA 98195, U.S.A. seanm6@u.washington.edu
Gibson
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CL
D002545:Brain Ischemia / Q000503:physiopathology*; D004789:Enzyme Activation; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000378:metabolism
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase