title: [Topiramate in chronic daily headache due to migraine].
abstract: BACKGROUND
  Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units.
  
  
  OBJECTIVE
  To evaluate the effectiveness of topiramate, as the primary drug, in CDH due to probable chronic migraine with or without medication abuse.
  
  
  METHODS
  From the 447 patients with migraine in our database, we selected those: a) satisfying Silberstein criteria for CDH; b) that had not followed prior prophylactic treatment; and c) who were treated with topiramate as the primary drug. The mean number of days with headache and bouts of severe migraine in the fourth month of treatment using topiramate as compared to the month preceding treatment, as well as the percentage of responses and the rate of respondents in the fourth month were all analysed.
  
  
  RESULTS
  Eighty-three patients (88% females) with a mean age of 38.0 +/- 14.13 years were selected. Medication abuse was reported in 44% of cases. At the fourth month of treatment, the mean number of days with headache dropped significantly from 20.8 to 7.9 (p < 0.0001) and the mean number of bouts of severe migraine diminished from 4.4 to 1.7 (p < 0.0001). The rate of respondents was 72%. Medication abuse continued in 14% of cases. Side effects were produced in 58% of patients and the dropout rate was 24%.
  
  
  CONCLUSIONS
  Topiramate proved to be effective in the treatment of CDH due to probable chronic migraine and with probable medication abuse in de novo migraine patients.
authors.affiliation: Servicio de Neurología, Hospital Universitario Miguel Servet, 50009, Zaragoza, Spain. gracia.naya@meditex.es
authors.forename: M
authors.initials: M
authors.lastname: Gracia-Naya
authors.forename: A M
authors.initials: AM
authors.lastname: Latorre-Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Ríos-Gómez
authors.forename: S
authors.initials: S
authors.lastname: Santos-Lasaosa
authors.forename: J A
authors.initials: JA
authors.lastname: Mauri
authors.forename: S
authors.initials: S
authors.lastname: Sánchez-Valiente
authors.forename: E
authors.initials: E
authors.lastname: López
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose