Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth.
OBJECTIVE
To analyze the association between umbilical cord cardiac troponin I (cTnI), obstetric Doppler, and birth acidemia.


METHODS
This prospective observational study was conducted on 58 singleton pregnancies at 3 Brazilian hospitals. Umbilical and middle cerebral artery Doppler velocimetry were performed 24 h prior to birth. At delivery, cord blood was collected for pH, blood gas analysis, and cTnI measurement.


RESULTS
Cardiac troponin I > or =0.20 ng/mL was detected in 5 neonates (8.6%). Centralization was recorded in 12 fetuses; 4 of these (33.3%) had detectable cTnI compared with 1/46 (2.2%) fetuses with normal Doppler (P=0.005). Acidemia was present in 60% of the neonates with detectable cTnI, compared with 15% of the neonates with undetectable cTnI (P=0.042).


CONCLUSIONS
Centralization and birth acidemia are associated with detectable cTnI in cord blood supporting the possibility of myocardial ischemia in these fetuses.
Alexandre
Sandra Maria
SM
Obstetrics Department, São Paulo Federal University, São Paulo, Brazil. Sandra.Alexandra@ig.com.br
D'Almeida
Vânia
V
Guinsburg
Ruth
R
Nakamura
Mary U
MU
Tufik
Sérgio
S
Moron
Antonio
A
D000138:Acidosis / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*; D016216:Ultrasonography, Prenatal
D019210:Troponin I