[Comparison of effects between China made sirolimus-eluting stents and bare stents for treating patients with acute myocardial infarction].
OBJECTIVE
To compare the clinical outcomes between China made sirolimus-eluting stents (SES) and bare metal stents (BMS) implantation in patients with acute myocardial infarction (AMI).


METHODS
Consecutive patients with AMI underwent primary percutaneous coronary intervention (PCI) were randomly divided into SES group (n = 87) and BMS group (n = 86). The incidence of major adverse cardiac events (MACE including death, reinfarction, in-stent thrombosis, restenosis rate, target vessel revascularization) up to 6 months post PCI were assessed.


RESULTS
Postprocedure vessel patency, enzymatic release, cardiac function, and the incidence of short-term MACE were similar between the two groups (all P > 0.05). Two in-stent thrombosis was diagnosed in the SES group and bare stents group respectively (2.4% vs. 2.3%, P > 0.05). At 6 months, In-stent restenosis rate (4.5% vs. 40.0%, P < 0.01) and the in-segment restenosis rate (6.8% vs. 44.9%, P < 0.01) as well as MACE (8.0% vs. 24.4%, P < 0.01), which is mainly due to a marked reduction in the risk of target vessel revascularization (3.4% vs. 11.6%, P < 0.05) were significantly lower in SES group compared to BMS group.


CONCLUSIONS
The China made SES were not associated with an increased risk of in-stent thrombosis but significantly reduced restenosis rate and MACE at 6 months post primary angioplasty in patients with AMI.
Jin
Hui-gen
HG
Department of Cardiology, Putuo Central Hospital, Shanghai 200062, China.
Liu
Zong-jun
ZJ
Yang
Wei
W
Wang
Wei-qing
WQ
Shi
Jia
J
Wang
Dong-yi
DY
Wang
Zhi-hua
ZH
Yu
Hong-mei
HM
Lai
Ying
Y
Shen
Jun
J
Fang
Ping
P
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D020123:Sirolimus / Q000008:administration & dosage*
D020123:Sirolimus