[A follow-up study about 52 cases of atypical lobular hyperplasia and lobular carcinoma in situ of the breast].
OBJECTIVE
To evaluate the biological behavior and treatment method for the breast atypical lobular hyperplasia (ALH) and breast lobular carcinoma in situ (LCIS).


METHODS
Seventeen cases of ALH and thirty-five cases of LCIS were reviewed from July 1982 to January 1996. All cases were followed by physical examination, mammography and B-ultrasound for an average of 146.6 months (range, 3 - 257 months).


RESULTS
Most cases of ALH and LCIS occurred before menopause (about 69.2%). Fifty-two cases of ALH and LCIS were occasionally verified pathologically after surgery for benign diseases. The microcalcification with ALH and LCIS had been detected in 25 cases, accounted for 48.1%. Eight cases of ALH/LCIS became invasive carcinoma. There were 5 cases in the same breast, 3 cases in the contralateral breast; The subsequent breast cancer occurred longer than nine years after ALH/LCIS was diagnosed. The family history of breast carcinoma and ovary carcinoma occurred in 4 cases of breast carcinoma, accounted for 50%, but it was no significant (P > 0.05). Also, there was no difference between LCIS and ALH, which occurred the breast carcinoma (P > 0.05).


CONCLUSIONS
The excisional biopsy might be necessary to ALH and LCIS.
Li
Hong-Yuan
HY
Department of General Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Ren
Guo-Sheng
GS
Arnould
Nasrin
N
Brettes
Jean-Philippe
JP
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors