title: A minimal model for glycemia control in critically ill patients.
abstract: In this paper we propose a modified minimal model to be used for glycemia control in critically ill patients. For various reasons the Bergman minimal model is widely used to describe glucose and insulin dynamics. However, since this model is mostly valid in a rather restrictive setting, it might not be suitable to be used in a model predictive controller. Simulations show that the new model exhibits a similar glycemia behaviour but clinically more realistic insulin kinetics. Therefore it is potentially more suitable for glycemia control. The designed model is also estimated on a set of critically ill patients giving promising results.
authors.affiliation: Katholieke Universiteit Leuven, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Van Herpe
authors.forename: Bert
authors.initials: B
authors.lastname: Pluymers
authors.forename: Marcelo
authors.initials: M
authors.lastname: Espinoza
authors.forename: Greet
authors.initials: G
authors.lastname: Van den Berghe
authors.forename: Bart
authors.initials: B
authors.lastname: De Moor
mesh_terms: D000368:Aged; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D016638:Critical Illness; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005951:Glucose Tolerance Test / Q000295:instrumentation*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D007328:Insulin