Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.
Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.
Reed
Julie E
JE
Department of Chemistry, Imperial College London, London, UK SW7 2AZ.
Neidle
Stephen
S
Vilar
Ramon
R
D004247:DNA / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D031541:Fluorescence Resonance Energy Transfer; D005782:Gels; D008024:Ligands; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010618:Phenanthrolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D019098:Telomerase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D005782:Gels; D008024:Ligands; D009944:Organoplatinum Compounds; D010618:Phenanthrolines; D004247:DNA; D019098:Telomerase