Triggered release of aqueous content from liposome-derived sol-gel nanocapsules.
Liposomes prepared from a mixture of L-alpha-dipalmitoylphosphatidylcholine and the PEGilated phospholipid N-(carbonylmethoxypoly(ethylene glycol 2000))-1,2-distearoyl-sn-glycero-3-phosphoethanolamine were used as templates for the production of silica and alkylated silica approximately 100 nm capsules, "liposils", entrapping aqueous solutions of anionic dyes. Triggered release of this content was successfully affected by either low-frequency ultrasound or by microwave treatments. Cryo-TEM was used to follow the formation process of these particles, which are aggregated in a chain-like manner. A mechanism explaining this phenomenon is suggested.
Steinberg
Yael
Y
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Schroeder
Avi
A
Talmon
Yeshayahu
Y
Schmidt
Judith
J
Khalfin
Rafail L
RL
Cohen
Yachin
Y
Devoisselle
Jean-Marie
JM
Begu
Sylvie
S
Avnir
David
D
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D000478:Alkylation; D005456:Fluorescent Dyes / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008560:Membrane Fluidity; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
D005456:Fluorescent Dyes; D005782:Gels; D008081:Liposomes; D008823:Micelles; D053769:Nanocapsules; D010714:Phosphatidylethanolamines; D014867:Water; D015060:1,2-Dipalmitoylphosphatidylcholine; D011092:Polyethylene Glycols; D012822:Silicon Dioxide