Clinical strategies to enhance T cell reconstitution.
Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.
Goldberg
Gabrielle L
GL
Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Zakrzewski
Johannes L
JL
Perales
Miguel A
MA
van den Brink
Marcel R M
MR
D051523:Fibroblast Growth Factor 7 / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000502:physiology; D013006:Growth Hormone / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D015851:Interleukin-7 / Q000494:pharmacology; D013601:T-Lymphocytes / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D015851:Interleukin-7; D051523:Fibroblast Growth Factor 7; D013006:Growth Hormone