Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression.
OBJECTIVE
This study aimed to determine the relationship between the C825T polymorphism in the G-protein beta 3 subunit (GNB3) gene and the response to mirtazapine in a Korean population with major depressive disorder (MDD).


METHODS
Mirtazapine was administered for 8 weeks to the 101 MDD patients who completed this study. All subjects were examined using the Structured Clinical Interview for DSM-IV, and the severity of depression was assessed using the 21-item Hamilton Depression Rating (HAMD-21) scale.


RESULTS
There was a significant main effect of time on the decrease in the HAMD-21 score during the 8-week study period. However, a main effect of or an interaction of genotype with time on the decrease in the HAMD-21 score during the 8-week study period was not found. ANOVA revealed no significant effects of the GNB3 C825T polymorphism on the decrease in the HAMD-21 score at each time period.


CONCLUSIONS
Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD.
Kang
Rhee-Hun
RH
Depression Center, Korea University, Seoul, Korea.
Hahn
Sang-Woo
SW
Choi
Myoung-Jin
MJ
Lee
Min-Soo
MS
D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008803:Mianserin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D000078785:Mirtazapine; D011110:Polymorphism, Genetic / Q000235:genetics*
D000929:Antidepressive Agents, Tricyclic; C454420:G-protein beta3 subunit; D008803:Mianserin; D000078785:Mirtazapine; D020962:Heterotrimeric GTP-Binding Proteins