title: Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea.
abstract: We report a case of Sydenham's chorea with neuropsychiatric symptoms who was successfully treated with low-dose risperidone. We also longitudinally investigated serum BDNF levels and plasma levels of catecholamine metabolite in the patient. Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease. These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease.
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakano
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sugita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimono
authors.forename: Kenchi
authors.initials: K
authors.lastname: Takano
authors.forename: Naoki
authors.initials: N
authors.lastname: Shiota
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tomoda
authors.forename: Yukunori
authors.initials: Y
authors.lastname: Korogi
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000188:drug therapy; D001479:Basal Ganglia / Q000000981:diagnostic imaging; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002395:Catecholamines / Q000097:blood*; D002819:Chorea / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D003702:Delusions / Q000150:complications / Q000188:drug therapy; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008137:Longitudinal Studies; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D011859:Radiography; D018967:Risperidone / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D002395:Catecholamines; D008734:Methoxyhydroxyphenylglycol; D018967:Risperidone