Synthesis of andrographolide derivatives and their TNF-alpha and IL-6 expression inhibitory activities.
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-alpha and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide.
Li
Jing
J
Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Huang
Wenlong
W
Zhang
Huibin
H
Wang
Xinyang
X
Zhou
Huiping
H
D000818:Animals; D002460:Cell Line; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015850:Interleukin-6 / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D004224:Diterpenes; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C030419:andrographolide