The non-human primate oocyte and embryo as a model for women, or is it vice versa?
The role of the non-human primate (NHP) oocyte and embryo in translational research is considered here including both in vitro activities directly involving oocytes or embryos as well as animal studies that impact reproductive function. Reasons to consider NHPs as animal research models along with their limitations are summarized. A case is made that in limited instances, such as in the development and application of the assisted reproductive technologies or in the study of embryonic stem cells, the human oocyte and embryo have acted as models for the monkey. The development of strategies for the preservation of fertility is used as an example of ongoing research in the non-human primate that cannot be conducted in women for ethical reasons. In animal studies, monitoring reproductive potential, responses to embryonic stem cell transplantation, along with translational research in the field of contraceptive development for women are considered as subjects that benefit from the availability of a NHP model.
Wolf
D P
DP
Oregon Health and Science University, Oregon National Primate Research Center, Beaverton, OR 97006, USA. wolfd@ohsu.edu
D000818:Animals; D005260:Female; D006801:Humans; D008251:Macaca / Q000196:embryology*; D023421:Models, Animal; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000662:veterinary*; D033581:Stem Cell Transplantation / Q000662:veterinary