[Sudden improvement of all neurological functions after general anesthesia and two-day intrathecal infusion of baclofen in a child with primary brain-stem injury].
An 11-year old girl suffered a diffuse axonal injury after car accident. On admission, she was unconscious (GCS 4) and presented with brain contusion, pulmonary contusion, severe tetraparesis, spasticity and seizures. She did not respond to sedatives and anti-epileptic drugs. After 18 days at Intensive Care Unit, she was selected to baclofen screening. She received 100 microg of baclofen and her spasticity decreased and motor and sensor aphasia resolved.
Kawecki
Zdzisław
Z
Oddział Neurochirurgii, Uniwersytecki Szpital Dzieciecy w Krakowie.
Kwiatkowski
Stanisław
S
Grzegorzewski
Przemysław
P
Szlachta Jezioro
Iwona
I
D000063:Accidents, Traffic; D000768:Anesthesia, General; D001037:Aphasia / Q000209:etiology; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects; D001933:Brain Stem / Q000293:injuries*; D002648:Child; D020833:Diffuse Axonal Injury / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007278:Injections, Spinal; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D009424:Nervous System Physiological Phenomena / Q000187:drug effects*; D016896:Treatment Outcome
D018755:GABA Agonists; D001418:Baclofen