Studies on terpenoids produced by actinomycetes: oxaloterpins A, B, C, D, and E, diterpenes from Streptomyces sp. KO-3988.
Following screening for terpenoids produced by Streptomyces sp. KO-3988, five new diterpenes named oxaloterpins A (1), B (2), C (3), D (4), and E (5) together with the known viguiepinone (6) were isolated from culture broth, and their structures were established on the basis of extensive NMR and MS analyses. The absolute configuration of oxaloterpin A was determined by the modified Mosher's method as 3 R, 5 S, 8 S, 10 R, 13 S.
Motohashi
Keiichiro
K
Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan.
Ueno
Ryoko
R
Sue
Masayuki
M
Furihata
Kazuo
K
Matsumoto
Takuo
T
Dairi
Tohru
T
Omura
Satoshi
S
Seto
Haruo
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004224:Diterpenes