Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection.
Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.
Sharma
Rajiv P
RP
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 912 S. Wood St., Chicago, IL 60612, United States. rsharma@psych.uic.edu
Grayson
Dennis R
DR
Gavin
David P
DP
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic / Q000706:statistics & numerical data; D044127:Epigenesis, Genetic / Q000235:genetics; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000706:statistics & numerical data; D005968:Glutamate Decarboxylase; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000201:enzymology / Q000378:metabolism*; D040081:Protein Array Analysis / Q000706:statistics & numerical data; D012333:RNA, Messenger; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D012737:Sex Factors; D000099186:Histone Deacetylase 3
D005968:Glutamate Decarboxylase; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases; D012333:RNA, Messenger; D012097:Repressor Proteins; D000099186:Histone Deacetylase 3; C110550:HDAC1 protein, human; C400300:HDAC4 protein, human; C402565:glutamate decarboxylase 1