title: [Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients].
abstract: OBJECTIVE
  To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients.
  
  
  METHODS
  Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin.
  
  
  RESULTS
  TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01).
  
  
  CONCLUSIONS
  C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.
authors.affiliation: Department of Cardiology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Nian-xin
authors.initials: NX
authors.lastname: Jiang
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D005838:Genotype; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D010837:Vitamin K 1; D064417:Vitamin K Epoxide Reductases; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D014859:Warfarin; D010837:Vitamin K 1; D006899:Mixed Function Oxygenases; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases