title: One-pot, large-scale synthesis of Nickel(II) complexes derived from 2-[N-(alpha-picolyl)amino]benzophenone (PABP) and alpha- or beta-amino acids.
abstract: A one-pot, large-scale procedure for preparing the Belokon-Soloshonok nucleophilic glycine equivalent 2-[N-(alpha-picolyl)amino]benzophenone (PABP) derived Ni(II) complex [GlyNi(II)PABP] is described. It has been accomplished by using isobutyl chloroformate to form PABP and then NaH/KOH as mixed bases to afford the corresponding complexes in a one-pot manner (up to an overall yield of 98%). The potential of this method for preparation of beta-amino acids derivatives, such as beta-AlaNi(II)PABP and beta-PheNi(II)PABP, has been demonstrated. The structure of beta-AlaNi(II)PABP is characterized by single-crystal X-ray diffraction.
authors.affiliation: Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Deng
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C525417:2-(N-(alpha-picolyl)amino)benzophenone; D000596:Amino Acids; D001577:Benzophenones; D009942:Organometallic Compounds; D009532:Nickel