Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis.
Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions. These junctional complexes are related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization. Endothelial junctional proteins play important roles in tissue integrity but also in vascular permeability, leukocyte extravasation and angiogenesis. In this review, we will focus on specific mechanisms of endothelial tight and adherens junctions.
Wallez
Yann
Y
Vascular Pathophysiology Laboratory, Inserm U882 38054 Grenoble, France.
Huber
Philippe
P
D022005:Adherens Junctions / Q000502:physiology* / Q000648:ultrastructure*; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000502:physiology; D015820:Cadherins / Q000737:chemistry / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology; D049109:Cell Proliferation; D003260:Contact Inhibition; D042783:Endothelial Cells / Q000502:physiology* / Q000648:ultrastructure*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D019108:Tight Junctions / Q000502:physiology* / Q000648:ultrastructure*; D051176:beta Catenin / Q000737:chemistry / Q000502:physiology; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D051176:beta Catenin; D000099152:Cadherin 5