title: Spinal cord stimulation modulates activity of lumbosacral spinal neurons receiving input from urinary bladder in rats.
abstract: The aim of this study was to determine whether spinal cord stimulation (SCS) modulates activity of lumbosacral spinal neurons receiving input from the urinary bladder. Extracellular potentials of L6-S2 spinal neurons were recorded in pentobarbital anesthetized, paralyzed and ventilated male rats. SCS (50 Hz, 0.2 ms, 3-5 min, 90% motor threshold) was applied on the dorsal column of L2-L3 and C1-C2 segments and significantly reduced excitatory responses of 18/25 (72%) and 13/19 (68%) lumbosacral neurons to noxious urinary bladder distension (UBD, > or =1.0 ml, 20 s), respectively. SCS affected spinal neurons with either high- or low-threshold responses to UBD. These results suggested that SCS might have a potential therapeutic effect for patients with hypersensitivity and/or pain of cystitis and other urinary bladder disorders.
authors.affiliation: Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. chao-qin@ouhsc.edu
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.forename: Jay P
authors.initials: JP
authors.lastname: Farber
authors.forename: Robert D
authors.initials: RD
authors.lastname: Foreman
mesh_terms: D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation / Q000379:methods*; D007796:Laminectomy / Q000379:methods; D008161:Lumbosacral Region; D008297:Male; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology* / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation* / Q000502:physiology