Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills.
BACKGROUND
Vulvar vestibulitis syndrome (VVS) is a diverse, multifactorial phenomenon. Its precise etiology is unknown.


OBJECTIVE
To define the association between oral contraceptive (OC) estrogen dosage and VVS. Methods. Women diagnosed as having VVS participated in the study.


METHODS
Data on type and usage of oral contraceptive pills (OC) were obtained by a questionnaire, and they were compared for the data on OC usage in the general population.


RESULTS
Available commercial data on Israeli women taking OC showed that 51% of them use low-dose estrogen (</=20 microg) OC and 49% use higher-dose estrogen (30-35 microg) OC. Of the 132 women in the study, 86 (65%) used OC: 68 (79%) used low-dose estrogen OC (P < 0.002 compared to the general population), while only 18 (21%) used high-dose estrogen OC (P < 0.002 compared to the general population).


CONCLUSIONS
Significantly more patients who are treated in our clinic for VVS use low-dose estrogen than those who use high-dose estrogen OC.
Greenstein
Alexander
A
Tel Aviv Sourasky Medical Center - Urology, Tel-Aviv, Israel. surge04@post.tau.ac.il
Ben-Aroya
Zahi
Z
Fass
Orit
O
Militscher
Idan
I
Roslik
Yelena
Y
Chen
Juza
J
Abramov
Liora
L
D000328:Adult; D003268:Contraception Behavior / Q000706:statistics & numerical data; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D054515:Vulvar Vestibulitis / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology*; D016387:Women's Health
D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens