title: Non-prescription supplement-induced hepatitis with hyperferritinemia and mutation (H63D) in the HFE gene.
abstract: A 55-year-old Japanese woman was hospitalized because liver function tests showed an abnormality. Transaminases and biliary enzymes were markedly elevated with hyperferritinemia. Her imaging tests revealed no significant abnormality. She had been taking various non-prescription supplements for over approximately 6 months. After the supplements were discontinued her liver function gradually improved. This clinical course was suggestive of supplement-induced hepatitis. She had no history of taking supplements containing iron, so it was interesting that she had hyperferritinemia. We examined C282Y and H63D, which are important mutations in theiron-metabolizing gene, HFE. She was found to be heterozygous for the H63D mutation. The interaction between hyperferritinemia and supplements is unknown, but it can be speculated that some interaction between iron overload and supplements may have underlain the pathogenesis of her liver injury.
authors.affiliation: Department of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Takagaki
authors.forename: Takaharu
authors.initials: T
authors.lastname: Yoh
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Morita
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohkawara
authors.forename: Kanji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Masahito
authors.initials: M
authors.lastname: Minami
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Sawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okanoue
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkawara
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Itoh