title: Effect of pneumoperitoneum on hemodynamics and inspiratory pressures during natural orifice transluminal endoscopic surgery (NOTES): an experimental, controlled study in an acute porcine model.
abstract: OBJECTIVE
  Physiologic reactions during natural orifice transluminal endoscopic surgery (NOTES) may differ from those at laparoscopy. This experimental study assessed the effect of pneumoperitoneum induced by endoscope air pump on hemodynamics and inspiratory pressures during transgastric peritoneoscopy.
  
  
  METHODS
  Transgastric peritoneoscopy was performed in 11 female pigs (35 - 50 kg) under general anesthesia. Five pigs with controlled insufflation and no endoscopic intervention served as controls. Cardiac index and global end-diastolic volume index (GEDVI; reflecting preload) were measured every 3 minutes by transpulmonary thermodilution. We also recorded: intra-abdominal pressure (IAP), heart rate, mean arterial pressure (MAP), systemic vascular resistance index (SVRI; reflecting afterload), peak inspiratory pressure (PIP), and oxygenation.
  
  
  RESULTS
  One study group pig was excluded from analysis because of a major complication related to the gastric incision. In the remaining 15 animals we performed 264 paired measurements. On-demand insufflation in the study group produced wide variation in intra-abdominal pressures; the control group demonstrated minimal fluctuation around a predetermined value. In the study group, IAP and PIP correlated well ( R = 0.667, P = 0.000), with maximum PIP values of 40 mbar contrasting with the control group maximum of 26.5 mbar. Hemodynamically, there was a minor decrease of cardiac index in the study group (in contrast to the control group). Relative changes in cardiac index and IAP during transgastric peritoneoscopy correlated highly significantly ( R = - 0.416, P = 0.000). Neither group showed hemodynamic instability or decline in oxygen saturation.
  
  
  CONCLUSIONS
  On-demand insufflation with a standard endoscopic light source/insufflator resulted in a marked median increase and wide variation in IAP throughout transgastric peritoneoscopy. Hemodynamic changes were moderate. However, major increases in PIP suggest a need for stricter control of intra-abdominal hypertension during NOTES.
authors.affiliation: 2nd Medical Department, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany. stefan_ruckert@yahoo.de
authors.forename: S
authors.initials: S
authors.lastname: von Delius
authors.forename: W
authors.initials: W
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Feussner
authors.forename: D
authors.initials: D
authors.lastname: Wilhelm
authors.forename: A
authors.initials: A
authors.lastname: Karagianni
authors.forename: J
authors.initials: J
authors.lastname: Henke
authors.forename: A
authors.initials: A
authors.lastname: Preissel
authors.forename: A
authors.initials: A
authors.lastname: Schneider
authors.forename: R M
authors.initials: RM
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Meining
mesh_terms: D034841:Abdominal Cavity / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D004867:Equipment Design; D005260:Female; D005767:Gastrointestinal Diseases / Q000503:physiopathology / Q000601:surgery; D006439:Hemodynamics / Q000502:physiology*; D001239:Inhalation / Q000502:physiology*; D007327:Insufflation / Q000295:instrumentation*; D020706:Laparoscopes; D010535:Laparoscopy / Q000379:methods*; D010092:Oximetry; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D011312:Pressure; D013270:Stomach / Q000601:surgery; D013552:Swine; D013815:Thermodilution / Q000379:methods