title: Engineering of pharmaceutical materials: an industrial perspective.
abstract: Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.
authors.affiliation: Pharmaceutical Development Services, Patheon, Inc., 2100 Syntex Court, Mississauga, Ontario, Canada L5N 7K9. kwok.chow@patheon.com
authors.forename: Kwok
authors.initials: K
authors.lastname: Chow
authors.forename: Henry H Y
authors.initials: HH
authors.lastname: Tong
authors.forename: Susan
authors.initials: S
authors.lastname: Lum
authors.forename: Albert H L
authors.initials: AH
authors.lastname: Chow
mesh_terms: D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D005079:Excipients; D015394:Molecular Structure; D004364:Pharmaceutical Preparations
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations