An improved NMR study of liposomes using 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine as model.
In this paper we report a comparative characterization of Small Unilamellar Vesicles (SUVs), Large Unilamellar Vesicles (LUVs) and Multilamellar Vesicles (MLVs) prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine (POPC), carried out using two NMR techniques, namely High Resolution NMR in solution and High Resolution-Magic Angle Spinning (HR-MAS). The size and size distributions of these vesicles were investigated using the dynamic light scattering technique. An improved assignment of the (1)H-NMR spectrum of MLVs is also reported.
Cruciani
Oscar
O
Istituto di Metodologie Chimiche, CNR, 00016 Monterotondo Stazione, Roma, Italy.
Mannina
Luisa
L
Sobolev
Anatoli P
AP
Cametti
Cesare
C
Segre
AnnaLaura
A
D008027:Light; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry*; D012542:Scattering, Radiation
D008081:Liposomes; D010713:Phosphatidylcholines; C028694:1-palmitoyl-2-oleoylphosphatidylcholine