title: One-pot synthesis of benzothiazolines and napthathiazolines via cascade ortho-lithiation, cyclisation and elimination of N-arylsulfonyl lactams.
abstract: ortho-Lithiation of cyclic aryl sulfonamides in the presence of phosphoryl chloride provides a very simple entry to fused polycyclic sultams (benzothiazolines and naphthathiazolines).
authors.affiliation: GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, UK SG1 2NY.
authors.forename: John D
authors.initials: JD
authors.lastname: Harling
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Steel
authors.forename: Tom M
authors.initials: TM
authors.lastname: Woods
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Yufit
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; D007769:Lactams; D009281:Naphthalenes; D013451:Sulfonic Acids; C058836:benzothiazoline; D008094:Lithium