title: [Assessment of morbid-obesity-associated comorbidities progression after surgical treatment with the duodenal crossing technique].
abstract: OBJECTIVE
  To assess the impact of weight loss in clinical progression of the comorbidities in a group of morbid obese patients submitted to surgical treatment with the duodenal switch technique.
  
  
  METHODS
  Between 2001-2006, we have operated by the duodenal crossing technique a total of 118 morbid obese patients (97 women and 21 men), mean age 42.6 years. Average pre-surgical BMI was 49.7, with average overweight of 69.1 kg. After surgical intervention, we have prospectively assessed the progression of the main comorbidities (arterial hypertension, diabetes, OSAS, osteoarticular pathology, dyslipidemia), according to the subscale of the BAROS scoring system. Postsurgical controls are done at months 3, 6, 12, 18, and 24 and annually thereafter. We have followed-up 110 patients, of whom 90 presented comorbidities, being the ones studied.
  
  
  RESULTS
  At 3 months post-surgery, we observed a decrease in the mean value of % WL to 31%, and a mean BMI value of 41.3, the percentage of lost BMI being 40.3%. Most of the weight loss occurred within 2 years, with % WL of 74.8% and a percentage of lost BMI of 97.7%. In 68 patients (75.5%) there was resolution of their comorbidities, 14.4% having improvement, and 10% with no improvement in spite of the surgery. Of patients achieving complete resolution, almost all of them achieved it within two years after surgery. Cure rates correlate with weight loss, so that at 3 months, with a mean weight loss of 25 kg (BMI decrease of 8.4 points) the comorbidity resolution rate is 45.5%. At 12 months, with a mean decrease in BMI of 16.4 points, % WL of 61.6% and % of lost BMI of 70.4%, the comorbidity resolution rate is 89.7%. At two years, by the time most of the main comorbidities resolved (68 patients), the BMI decreased by 22.4 points, the % WL 74.8% and the % of lost BMI 97.9%.
  
  
  CONCLUSIONS
  The aim of bariatric surgery is weight loss and overweight-associated comorbidities improvement. In our study, most of the comorbidities improvement started at the third month, with the highest improvement rate occurring within two years, verifying that there is a direct relationship between post-surgical weight loss comorbidities improvement and resolution in most of the cases.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital General Universitario de Valencia, España. avprado23@ono.com
authors.forename: A
authors.initials: A
authors.lastname: Vázquez Prado
authors.forename: E Ma
authors.initials: EM
authors.lastname: Montalvá Orón
authors.forename: L C
authors.initials: LC
authors.lastname: de Tursi Ríspoli
mesh_terms: D000328:Adult; D000368:Aged; D050110:Bariatric Surgery / Q000379:methods / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D018450:Disease Progression; D004386:Duodenum / Q000601:surgery*; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000601:surgery; D010003:Osteoarthritis / Q000453:epidemiology; D011446:Prospective Studies; D012074:Remission Induction; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology