title: [The opportunities of the photodynamic therapy (PDT) in bones' tumours treatment].
abstract: The bones tumors represent in orthopedic surgery frequently affection. Among the most often diagnosed primary malignant bones tumors there are: osteosarcoma, chondrosarcoma, gigantocellular tumour of the bone, the Ewing sarcoma. Nearly 35% patients, who start their treatment, have unfortunately, disseminated neoplastic illness (metastases). The much bigger problem (25 times often find than primary neoplasms) are metastatic tumours direct to the bones. Inspite of accessible widespread therapeutic spectrum (multidrugs chemotherapy, surgical tumors' resection, radiotherapy, interferon, genic therapy) five years patients' survival are observed only in small percentage. Therefore, there is a requirement to find more effective and also less invasive method of treatment. The submission of this method seems to be photodynamic therapy (PDT). PDT based on the cytotoxic activity of the laser light and photosensitizer on the neoplastic tissue. Nowdays, there are accepted lines of conduction and closely characterized the indications to PDT in neoplastic diseases. Based on a high grade of efficiency, and also selectivity of PDT, it seems very purposeful to make the investigations about possibilities of PDT in the neoplastic tumours in orthopedics.
authors.affiliation: Wojewódzki Szpital Chirurgii Urazowej w Piekarach Slaskich.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Spindel
authors.forename: Tomasz
authors.initials: T
authors.lastname: Walentek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stoltny
authors.forename: Bogdan
authors.initials: B
authors.lastname: Koczy
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szlachta
authors.forename: Andrzej
authors.initials: A
authors.lastname: Frankiewicz
authors.forename: Karolina
authors.initials: K
authors.lastname: Sieroń-Stoltny
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kawczyk-Krupka
authors.forename: Aleksander
authors.initials: A
authors.lastname: Sieroń
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents