Early life programming of energy balance.
Obesity prevalence is increasing worldwide, leading to increased morbidity, mortality and health care costs due to its role as a key risk factor in many diseases. Early life growth and nutrition has been implicated in determining susceptibility to obesity in both childhood and adulthood; however, the mechanisms underlying this link are poorly understood. A variety of animal models have been established to try and uncover the developmental programming effects of maternal early life nutrition on energy balance regulation and the mechanisms behind them.
Cripps
R L
RL
Department of Clinical Biochemistry, University of Cambridge, Level 4, Box 232, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K. rlc34@cam.ac.uk
Archer
Z A
ZA
Mercer
J G
JG
Ozanne
S E
SE
D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D023421:Models, Animal