Treatment of incomplete abortion and miscarriage with misoprostol.
A literature review was conducted to determine whether misoprostol is an effective treatment for incomplete abortion and, if so, to recommend an appropriate regimen. All English language articles published before October 2007 using misoprostol in at least one of the study arms were reviewed to determine the efficacy of misoprostol when used to treat incomplete abortion in the first trimester. All available unpublished data previously presented at international scientific meetings were also reviewed. Sufficient evidence was found in support of misoprostol as a safe and effective means of non-surgical uterine evacuation. A single dose of misoprostol 600 microg oral is recommended for treatment of incomplete abortion in women presenting with a uterine size equivalent to 12 weeks gestation.
Blum
J
J
Gynuity Health Projects, New York, NY 10010, USA. jblum@gynuity.org
Winikoff
B
B
Gemzell-Danielsson
K
K
Ho
P C
PC
Schiavon
R
R
Weeks
A
A
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000027:Abortion, Incomplete / Q000175:diagnosis / Q000188:drug therapy*; D000022:Abortion, Spontaneous / Q000175:diagnosis / Q000188:drug therapy*; D000284:Administration, Oral; D000286:Administration, Sublingual; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol