Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi.
In this study, the antifungal activities of cinnamaldehyde and eugenol congeners against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus were evaluated and the relationships between the antifungal activity and the chemical structures were also examined. Results from antifungal tests revealed that cinnamaldehyde, alpha-methyl cinnamaldehyde, (E)-2-methylcinnamic acid, eugenol and isoeugenol exhibited strong antifungal activity against all fungi tested. Results derived from the chemical structure-antifungal activity relationship study suggested that compounds with an aldehyde group or an acid group, a conjugated double bond and a length of CH chain outside the ring affect their antifungal properties. Furthermore, the presence of the methyl moiety in the ortho position may have a considerable influence on the inhibitory action against L. betulina and L. sulphureus. In addition, the lipophilicity may play, in part, a crucial role in determining the toxicity of phenylpropenes.
Cheng
Sen-Sung
SS
The Experimental Forest, National Taiwan University, Nan-Tou 557, Taiwan.
Liu
Ju-Yun
JY
Chang
Ed-Haun
EH
Chang
Shang-Tzen
ST
D000171:Acrolein / Q000031:analogs & derivatives* / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D005054:Eugenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010935:Plant Diseases / Q000382:microbiology*; D014934:Wood / Q000187:drug effects / Q000382:microbiology*
D000935:Antifungal Agents; D005054:Eugenol; C036643:isoeugenol; D000171:Acrolein; C012843:cinnamaldehyde