title: Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance.
abstract: Cognitive deficits are a major determinant of social and occupational dysfunction in schizophrenia, and new treatments are needed that address these impairments. The current study determined whether neurocognitive enhancement therapy (NET) in combination with work therapy (WT) would show improvement in performance on neuropsychological tests that endured 6 months after completion of training. A total of 145 participants with schizophrenia or schizoaffective disorder were randomly assigned to NET + WT or WT alone. NET included computer-based training on attention, memory, and executive function tasks. WT included paid work activity in job placements at the medical center. Neuropsychological assessment was performed at baseline, at the end of the 6-month active intervention, and 12 months after training began. Repeated measures multivariate analyses of variance revealed greater neuropsychological improvements on working memory (p < 0.05) and executive function (p < 0.05) for the NET + WT group over the 12 months. Both groups showed sustained improvements on verbal and nonverbal memory.
authors.affiliation: Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA.
authors.forename: Morris
authors.initials: M
authors.lastname: Bell
authors.forename: Joanna
authors.initials: J
authors.lastname: Fiszdon
authors.forename: Tamasine
authors.initials: T
authors.lastname: Greig
authors.forename: Bruce
authors.initials: B
authors.lastname: Wexler
authors.forename: Gary
authors.initials: G
authors.lastname: Bryson
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology / Q000534:rehabilitation; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D012050:Rehabilitation, Vocational / Q000379:methods*; D012073:Remedial Teaching / Q000379:methods*; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D013997:Time Factors; D016896:Treatment Outcome; D014937:Work / Q000523:psychology*