Effects of K. lysolecithin on blood levels of monoamines in mice.
In this research, Lysolecithin - a substance made with 100% natural ingredients - was given to ICR mice as medication to measure its periodic effect on the noradrenalin (NA), dopamine (DA), and serotonin (5-HT) levels of the brain. Both ICR and SAM mice were separated into two groups - control group and Lysolecithin (K. Lysolecithin: hydrolytic lysolecithin) medicated group, and given 1-week preparation period. The K. Lysolecithin group was given 500 mg/kg of K. Lysolecithin at 0.2 mL per dosage for 4 weeks, and the control group was given the same amount of dosage of water during the same period. NA, DA and 5-HT concentrations were measured from the blood before medication and 8 weeks/12 weeks/16 weeks after the first medication. For the SAM mice, 8 weeks after they were medicated with K .Lysolecithin, Morris Water Maze Test was conducted for 7 consecutive days and then the concentrations were measured by drawing blood from the heart. The K. Lysolecithin medicated group showed a tendency to have a statistically significant higher concentrations of 5-HT and NA in the blood. Also, periodic examination showed that the monoamine levels were highest in the 12th week and declined thereafter.
Itokwa
Yuka
Y
Suzuka Univercity of Medical Science, Graduate School of Health Science, 510-0293, Japan.
Kozu
Aki
A
Nakamura
Takashi
T
Masubuchi
Takashi
T
Oshima
Masami
M
Cho
Kwang-Ho
KH
Choi
Jung-Sook
JS
Miura
Toshihiro
T
Ishida
Torao
T
Gu
Yeunhwa
Y
D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D015306:Biogenic Monoamines / Q000097:blood*; D004195:Disease Models, Animal; D006801:Humans; D008244:Lysophosphatidylcholines / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008822:Mice, Transgenic; D011897:Random Allocation
D015306:Biogenic Monoamines; D008244:Lysophosphatidylcholines