title: Assessment of acute skin irritation in rabbits using electrical impedance model.
abstract: This paper describes the use of an electrical impedance model to assess acute skin reactions to irritant over time. The applied method is noninvasive and quantitative and can detect the irritation before the visual signs. The results showed that the signs of acute irritation (oedema) were present until the second day after irritant application. The method is able to detect the initial phase of irritation and the assessment of regeneration time could be attained by a combination of more than one bioengineering methods.
authors.affiliation: Biomed. Eng. Program, Univ. Fed. do Rio de Janeiro, Brazil.
authors.forename: D M
authors.initials: DM
authors.lastname: Ferreira
authors.forename: C S
authors.initials: CS
authors.lastname: Silva
authors.forename: M N
authors.initials: MN
authors.lastname: Souza
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D017453:Dermatitis, Irritant / Q000175:diagnosis* / Q000209:etiology; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D017097:Electric Impedance; D007509:Irritants; D008954:Models, Biological; D010992:Plethysmography, Impedance / Q000379:methods*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012967:Sodium Dodecyl Sulfate
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate