title: 188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits.
abstract: Polyacrylamide-coated magnetic nanogels were synthesized via photochemical method in surfactants and initiators free aqueous system at room temperature. After Hoffmann elimination of carbonyl and further modification with methoxy poly(ethylene glycol) (MPEG), the MPEG-modified superparamagnetic nanogels (MSN) with better hydrophilicity and biocompatibility were obtained. The MSN were characterized by FTIR, XRD, SEM and PCS. Covalently linked with 188Re complex, the 188Re-labeled MSN were prepared and intravenously injected into the left ears of the anesthetized rabbits in control group (without external magnetic field) or in targeting group (in presence of external magnetic field). The average radioactivity distribution of organs in control group was detected and the magnetic targeting feature was investigated in targeting group.
authors.affiliation: Dezhou University, Dezhou, Shangdong, 253023, Peoples' Republic of China. hanwensun916@yahoo.com.cn
authors.forename: Hanwen
authors.initials: H
authors.lastname: Sun
authors.forename: Lianying
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiuling
authors.initials: X
authors.lastname: Zhang
authors.forename: Cunlan
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Wei
authors.forename: Side
authors.initials: S
authors.lastname: Yao
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels / Q000737:chemistry; D008280:Magnetics; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D009928:Organ Specificity; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011817:Rabbits; D011868:Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics; D012211:Rhenium / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D005782:Gels; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D011092:Polyethylene Glycols; D012211:Rhenium; C028210:monomethoxypolyethylene glycol