[Shorten treatment of in children severe osteomyelitis].
Recommendations on treatment of acute staphylococcal osteomyelitis of children, based mostly on retrospective analyses, comprise up to 6 weeks for antimicrobials and the possibility of switching to the oral route only when the clinical and biological situation are under control. Some prospective non comparative studies suggest a good efficacy of simplified regimen: treatment initiated intravenously but switched to oral administration within few days, using high dosage. However, this type of treatment should be considered only for oral drugs with good pharmacokinetics/pharmacodynamic parameters as clindamycin of some first generation cephalosporins.
Cohen
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R
Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Service de Microbiologie, Hôpital Necker Enfants-Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France. robert.cohen@wanadoo.fr
D000284:Administration, Oral; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D015201:Meta-Analysis as Topic; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D011446:Prospective Studies; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002981:Clindamycin