Influence of respiratory instability during neurocardiogenic presyncope on cerebrovascular and cardiovascular dynamics.
OBJECTIVE
To analyse the influence of breathing activity on cerebrovascular dynamics during presyncope.


METHODS
Retrospective study.


METHODS
University hospital.


METHODS
38 subjects developing neurocardiogenic syncope (syncope group), and 61 age-matched control subjects with negative tilt.


METHODS
Middle cerebral artery mean blood flow velocity (MCFV), continuous non-invasive blood pressure (BP), end-tidal CO(2) (CO(2)-et) and minute ventilation were measured before and during 45' 60 degrees tilting.


METHODS
Respiratory and cerebrovascular variability, cerebrovascular resistance (CVR)-absolute and corrected for CO(2)-et at 40 mm Hg (CVR-40)-and dynamic cerebrovascular regulation (CVR-dyn: transfer function phase analysis between MCFV and BP), obtained during supine rest (baseline), first 5 minutes of tilt (early tilt), early- and late presyncope (first and second half, respectively, of 4 minutes preceding syncope in syncope group, and equivalent time in controls).


RESULTS
Tilting induced a mean (SE) CVR decrease in controls (baseline 1.20 (0.04); late presyncope 1.12 (0.06) mm Hg x s/cm, p<0.05) but not in the syncope group (baseline 1.09 (0.04); late presyncope 1.09 (0.06) mm Hg x s/cm, p = NS). However, CVR-40 showed similar reduction in both groups (controls: from 1.15 (0.04) to 0.96 (0.04) mm Hg x s/cm; syncope group: from 1.01 (0.04) to 0.83 (0.04) mm Hg x s/cm, p = NS). CVR-dyn of the two groups was also similar (p = NS). Respiratory variability increased in the syncope group, from early tilt to late presyncope (p<0.05 or better), preceding hyperventilation and being significantly correlated with an increase in MCFV and BP variability (p<0.01).


CONCLUSIONS
During presyncope, the development of respiratory instability and hypocapnia impairs MCFV, thus facilitating the onset of syncope despite preserved cerebrovascular regulation.
Porta
C
C
Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy.
Casucci
G
G
Castoldi
S
S
Rinaldi
A
A
Bernardi
L
L
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002245:Carbon Dioxide / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D016857:Hypocapnia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012189:Retrospective Studies; D013575:Syncope / Q000150:complications / Q000503:physiopathology*; D019462:Syncope, Vasovagal / Q000150:complications / Q000503:physiopathology; D018667:Tilt-Table Test / Q000379:methods
D002245:Carbon Dioxide