Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus.
Two distinct pathways of gamma interferon (IFN-gamma) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN-gamma production and requires the secretion of interleukin-12. This regulation of IFN-gamma production by type I interferons may help to control indirect pathogenesis induced by this cytokine.
Le-Thi-Phuong
Thao
T
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Bruxelles, Belgium.
Thirion
Gaëtan
G
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Bruxelles, Belgium.
Coutelier
Jean-Paul
JP
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Bruxelles, Belgium.
D000818:Animals; D005786:Gene Expression Regulation; D007370:Interferon Type I / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis*; D018664:Interleukin-12 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D007772:Lactate dehydrogenase-elevating virus / Q000276:immunology*; D053858:Metabolic Networks and Pathways; D051379:Mice
D007370:Interferon Type I; D018664:Interleukin-12; D007371:Interferon-gamma