title: Epidemiology and neurobiology of female sexual dysfunction.
abstract: BACKGROUND
  Although several conceptual frameworks for female sexual dysfunction (FSD) have been advanced, there still is considerable disagreement over what constitutes a normal vs. abnormal response. Sexual dysfunction is a disturbance in sexual functioning involving one or multiple phases of the sexual response cycle or pain associated with sexual activity, while a sexual disorder includes both dysfunction and marked distress.
  
  
  OBJECTIVE
  Review the literature regarding the epidemiology and neurobiology of FSD.
  
  
  METHODS
  Review of the literature.
  
  
  RESULTS
  While a wide range of epidemiologic studies has been published, it is still difficult to determine the scope of FSD and sexual disorders in the general population. It is becoming clear that good sexual health is associated with good physical and mental health as well as compatible relationships with one's sexual partner. Central nervous system (CNS) control of the sexual response is a relatively new area of scientific exploration.
  
  
  CONCLUSIONS
  We are improving our understanding of the contributions of the CNS neuroendocrine and neurotransmitter systems that modulate sexual behavior.
authors.affiliation: Department of Psychiatry & Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22903, USA. ahc8v@virginia.edu
authors.forename: Anita H
authors.initials: AH
authors.lastname: Clayton
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology*; D004703:Endocrine System / Q000503:physiopathology; D005260:Female; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology* / Q000503:physiopathology*; D020018:Sexual Dysfunctions, Psychological / Q000453:epidemiology* / Q000503:physiopathology*
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents