title: Fusion of enveloped virus nanoparticles with polyelectrolyte-supported lipid membranes for the design of bio/nonbio interfaces.
abstract: Fusion of lipid-enveloped viruses with endosomal membranes triggered by low pH in the endosome is a key step in the course of viral infection. This ubiquitous mechanism can be used to integrate functional nanoparticles of viral origin into composite materials consisting of a polyelectrolyte multilayer with an adsorbed lipid membrane in a natural and biomimetic way. Polyelectrolyte multilayers as the support for the lipid membrane are a versatile means to combine the biological functions of the viral surface with the multiplicity of polyelectrolyte borne functions into a novel bio/nonbio composite material.
authors.affiliation: Institute of Medical Physics and Biophysics, Leipzig University, Leipzig, Germany. mrtin.fischlechner@medizin.uni-leipzig.de
authors.forename: Martin
authors.initials: M
authors.lastname: Fischlechner
authors.forename: Uta
authors.initials: U
authors.lastname: Reibetanz
authors.forename: Markus
authors.initials: M
authors.lastname: Zaulig
authors.forename: Dirk
authors.initials: D
authors.lastname: Enderlein
authors.forename: Julia
authors.initials: J
authors.lastname: Romanova
authors.forename: Stefano
authors.initials: S
authors.lastname: Leporatti
authors.forename: Sergio
authors.initials: S
authors.lastname: Moya
authors.forename: Edwin
authors.initials: E
authors.lastname: Donath
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry*; D011992:Endosomes / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry; D008566:Membranes / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties; D013997:Time Factors; D014759:Viral Envelope Proteins / Q000737:chemistry*; D014780:Viruses / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D003102:Colloids; D004573:Electrolytes; D008055:Lipids; D014759:Viral Envelope Proteins