title: Combining optical imaging and computational modeling to analyze structure and function of living neurons.
abstract: We are investigating the computational properties of principal neurons in the mammalian brain. To manage the small size and intricate structure of neuronal dendrites, we employ advanced optical imaging techniques in combination with automatic image reconstruction and computational modeling to study their complex spatio-temporal pattern of activity.
authors.affiliation: Dept. of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. blosavio@cns.bcm.tmc.edu
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Losavio
authors.forename: G Duemani
authors.initials: GD
authors.lastname: Reddy
authors.forename: Costa M
authors.initials: CM
authors.lastname: Colbert
authors.forename: Ioannis A
authors.initials: IA
authors.lastname: Kakadiaris
authors.forename: Peter
authors.initials: P
authors.lastname: Saggau
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002478:Cells, Cultured; D003198:Computer Simulation; D008856:Microscopy, Fluorescence / Q000379:methods*; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D018511:Systems Integration