Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins.
The inability of human immunodeficiency virus type 1(HIV-1) to replicate in rhesus macaque cells is in part due to the failure of HIV-1 Vif to counteract the restriction factor APOBEC3G. However, in this study we demonstrate that several rhesus macaque APOBEC3 (rhAPOBEC3) proteins are capable of inhibiting HIV-1 infectivity. There was considerable variation in the ability of a panel of Vif proteins to induce degradation of rhAPOBEC3 proteins, and mutations within HIV-1 Vif that render it capable of degrading rhAPOBEC3G did not confer activity against other antiviral rhAPOBEC3 proteins. These findings suggest that multiple APOBEC3 proteins can contribute to primate lentivirus species tropism.
Virgen
Cesar A
CA
Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016, USA.
Hatziioannou
Theodora
T
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D043525:Cytosine Deaminase / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D016346:Gene Products, vif / Q000235:genetics / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008253:Macaca mulatta / Q000821:virology*; D016415:Sequence Alignment; D014779:Virus Replication / Q000187:drug effects; D054320:vif Gene Products, Human Immunodeficiency Virus / Q000235:genetics / Q000378:metabolism*
D016346:Gene Products, vif; D054320:vif Gene Products, Human Immunodeficiency Virus; D043525:Cytosine Deaminase