Synthesis of substituted furoates from acrylates and aldehydes by Pd(OAc)(2)/HPMoV/CeCl(3)/O(2) system.
A new synthetic method of substituted furoates from acrylates and aldehydes was developed by Pd(OAc)2 combined with molybdovanadophosphoric acid and Lewis acid under atmospheric dioxygen. The reaction was found to proceed through the palladium-catalyzed acetalization of acrylates with methanol followed by the reaction of the resulting acetals with aldehydes.
Tamaso
Ken-ichi
K
Department of Chemistry and Material Engineering, Faculty of Chemistry, Materials and Bioengineering and High Technology Research Center, Kansai University, Suita, Osaka, Japan.
Hatamoto
Yuji
Y
Obora
Yasushi
Y
Sakaguchi
Satoshi
S
Ishii
Yasutaka
Y
D000085:Acetates / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000179:Acrylates; D000447:Aldehydes; D005663:Furans; D009942:Organometallic Compounds; D010756:Phosphoric Acids; C516071:palladium(II) acetate; D002563:Cerium; D008982:Molybdenum; D010100:Oxygen; C026690:cerous chloride