[Clinical value of tumor-associated growth factor detection in the diagnosis of colorectal carcinoma].
OBJECTIVE
To investigate the diagnostic value of tumor-supplied growth factors (TSGF) in patients with colorectal carcinoma.


METHODS
The serum content of TSGF was determined in 71 patients with colorectal carcinoma 71, 55 with benign tumor, and 100 healthy volunteers with colorimetry.


RESULTS
TSGF concentration and its positivity rate were both significantly higher in colorectal carcinoma patients (81.5 x 10(3) U/L/71%) than in normal controls (55.7 x 10(3) U/L/3%) and patients with benign tumor (57.2 x 10(3)U/L/7.4%).TSGF positivity rate was independent of the patients' age, gender and stage of colorectal carcinoma. The diagnostic sensitivity of TSGF was 71% for colorectal carcinoma, higher than that of carcinoembryonic antigen (43.7%).


CONCLUSIONS
TSGF is more sensitive than carcinoembryonic antigen for early diagnosis of colorectal carcinoma.
Yang
Jing
J
Department of Clinical Laboratory, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China. angieyangyang@sina.com.cn
Wang
Dong
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor