title: Patients with hyperhidrosis have changed grip force, coefficient of friction and safety margin.
abstract: OBJECTIVE
  To evaluate whether subjects with palmar hyperhidrosis have functional problems with the handgrip caused by the wet slippery surface of palm and fingertips. We used two different dosages of botulinum toxin to explore its impact on sweating and on muscle strength in the hand.
  
  
  METHODS
  Using an object equipped with force sensors we measured the muscle strength and calculated the coefficients of friction and safety margin (SM) in the precision grip before and 2, 4, 6, 8 10-12 weeks and 6 months after treatment of 13 patients with two different doses of botulinum toxin. Sweat evaporation was measured simultaneously.
  
  
  RESULTS
  A significant decrease in evaporation and a parallel reduction of grip force in the dominant hand of the patients were observed. The SM used by the patients was significantly lower after the treatment, and increased gradually when sweating reappeared.
  
  
  CONCLUSIONS
  These measurements showed, for the first time, that hyperhidrosis of the palms may cause an objective perturbation of the hand function which may be partially corrected by botulinum toxin treatment.
authors.affiliation: Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden. theresa.zackrisson@neuro.gu.se
authors.forename: T
authors.initials: T
authors.lastname: Zackrisson
authors.forename: B
authors.initials: B
authors.lastname: Eriksson
authors.forename: N
authors.initials: N
authors.lastname: Hosseini
authors.forename: B
authors.initials: B
authors.lastname: Johnels
authors.forename: A-L
authors.initials: AL
authors.lastname: Krogstad
mesh_terms: D000293:Adolescent; D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000494:pharmacology / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005385:Fingers / Q000294:innervation / Q000503:physiopathology; D017276:Friction; D018737:Hand Strength; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008465:Mechanoreceptors; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D053580:Muscle Strength / Q000187:drug effects; D018908:Muscle Weakness / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D011434:Proprioception / Q000187:drug effects; D012449:Safety; D012678:Sensation Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D011984:Sensory Receptor Cells / Q000503:physiopathology; D014110:Touch; D016896:Treatment Outcome
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins