title: [The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils].
abstract: OBJECTIVE
  To investigate the expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils and its clinical significance.
  
  
  METHODS
  Under the light microscopy, HE and immunohistochemistry methods were used to show the morphology of HEVs, the number of T, B lymphocytes, the expression intensity of FasL and ICAM-1 in 17 patients with the idiopathic tonsillar hypertrophy (ITH) and in 20 patients with the chronic hypertrophic tonsillitis (CHT).
  
  
  RESULTS
  The expression intensity of ICAM-1 on the tonsillar HEVs in ITH group was significantly lower than that in CTH group (P < 0.05), but the intensity of FasL in ITH group was significantly higher than that in CHT group (P < 0.05).
  
  
  CONCLUSIONS
  FasL and ICAM-1 expression in the tonsillar HEVs contribute to the CHT and ITH. The former mainly makes IHT developed, and the latter promotes the process of the inflammation.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery,Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Wang
authors.forename: Haijing
authors.initials: H
authors.lastname: Yu
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Shenghong
authors.initials: S
authors.lastname: Liu
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004727:Endothelium / Q000098:blood supply; D053222:Fas Ligand Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D014069:Tonsillitis / Q000378:metabolism*; D014699:Venules / Q000378:metabolism*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D018799:Intercellular Adhesion Molecule-1