[Primary thrombophilia in México. VI: lack of statistical association among the inherited thrombophilic conditions].
OBJECTIVE
Over a 70-month period, 100 consecutive Mexican mestizo individuals with a clinical marker associated with a primary hypercoagulable state were studied.


METHODS
We prospectively assessed: the sticky platelet syndrome (SPS), the activated protein C resistance (aPCR) phenotype, coagulation protein C activity and antigen, coagulation protein S, antithrombin III, plasminogen, IgG and IgM isotypes of antiphospholipid antibodies, homocysteine levels, the factor V gene Leiden, Cambridge, Hong Kong, and Liverpool mutations, the 677 C-->T mutation in the 5,10-methylenetetrahydrofolatereductase (MTHFR), and the G20210A polymorphism in the 3'-untranslated region of the prothrombin gene.


RESULTS
Of the 100 consecutive patients prospectively accrued in the study, only 29% were males. In only 6 individuals could we not record any abnormality, whereas in most individuals (81%), two to five co-existing abnormalities were identified. In a multivariate analysis of the association of all these assesments, the only significant association was found between the factor V Leiden mutation and the aPCR phenotype (r = .495; p < 0.001).


CONCLUSIONS
These results confirm previous observations on thrombophilia in Mexico underlining that it is a multifactorial disease. They also suggest that the abnormalities detected are not associated to each other.
Ruiz-Argüelles
Guillermo J
GJ
Centro de Hematología y Medicina Intema de Puebla, Puebla, México. gruiz1@clinicaruiz.com
González-Carrillo
Martha L
ML
Estrada-Gómez
Roberto
R
Valdés-Tapia
Patricia
P
Parra-Ortega
Israel
I
Porras-Juárez
Angélica
A
D020016:Activated Protein C Resistance / Q000453:epidemiology / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D001791:Blood Platelet Disorders / Q000453:epidemiology / Q000235:genetics; D002648:Child; D005165:Factor V; D005260:Female; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D010641:Phenotype; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012737:Sex Factors; D019851:Thrombophilia / Q000453:epidemiology* / Q000235:genetics*; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics
C119012:factor V Cambridge; C403771:factor V Hong Kong; C095381:factor V Leiden; D005165:Factor V