Synaptic amplification in motoneurons: computational and mechanistic implications.
Motoneurons are known to possess the latent ability to amplify their inputs in a voltage-dependent manner. Additionally, this synaptic amplification is known to be under neuromodulatory control. This paper presents results from a computer modeling study for one possible mechanism, termed electrotonic compression, which could underlie this behavior.
Shapiro
Nicholas P
NP
Wallace H. Coulter Dept. of Biomedical Engineering, Emory University, Atlanta, GA 30322, USA. ns73@mail.gatech.edu
Lee
Robert H
RH
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena / Q000379:methods; D003198:Computer Simulation; D003713:Dendritic Cells / Q000502:physiology; D005246:Feedback / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*