title: Characterization of mouse brain and its development using diffusion tensor imaging and computational techniques.
abstract: Diffusion tensor magnetic resonance imaging (DTI) was used to study mouse brain development from early embryonic stage to adult. DTI provides necessary resolution and superb white matter and gray matter contrast in embryonic and neonatal brains for characterization of morphological changes during mouse brain development. A database and a digital atlas of developing mouse brains based on our DTI results are being constructed. To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA. jzhang3@jhmi.edu
authors.forename: Jiangyang
authors.initials: J
authors.lastname: Zhang
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Richards
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
authors.forename: Paul
authors.initials: P
authors.lastname: Yarowsky
authors.forename: Peter
authors.initials: P
authors.lastname: van Zijl
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology / Q000502:physiology; D000465:Algorithms; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000196:embryology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging*; D009474:Neurons / Q000166:cytology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography