title: [Postoperative radiotherapy treatment of early breast cancer].
abstract: Postoperative radiotherapy (RT) is an important part of the multidisciplinary treatment of early breast cancer. Meta-analyses of large randomized trials of RT after lumpectomy and mastectomy have shown that RT reduces the risk of local recurrence with at least 70% and mortality after 15 years with 5%. The effect is most pronounced in patients with a high risk of local recurrence, but is independent of adjuvant systemic treatment. Late radiation effects, in particular cardiac mortality can now be avoided using modern treatment technique. However, there is a continuous need to find the overall balance between the risk and benefit of RT based on individual prognostic parameters and technical possibilities.
authors.affiliation: Arhus Universitetshospital, Arhus Sygehus. marie@oncology.dk
authors.forename: Marie
authors.initials: M
authors.lastname: Overgaard
authors.forename: Marianne Ewertz
authors.initials: ME
authors.lastname: Kvistgaard
authors.forename: Mette Skovhus
authors.initials: MS
authors.lastname: Thomsen
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008408:Mastectomy; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011182:Postoperative Care; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant