Pharmaceutical applications of hot-melt extrusion: Part II.
The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
Repka
Michael A
MA
Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. marepka@olemiss.edu
Battu
Sunil Kumar
SK
Upadhye
Sampada B
SB
Thumma
Sridhar
S
Crowley
Michael M
MM
Zhang
Feng
F
Martin
Charles
C
McGinity
James W
JW
D002214:Capsules; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D011786:Quality Control; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D002214:Capsules; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D013607:Tablets