title: Nodular glomerulosclerosis in a kidney transplant recipient who smokes.
abstract: Cigarette smoking may have harmful effects on both native and transplant kidneys. Although a causal relationship was not shown, nodular glomerulosclerosis was reported in association with long-term cigarette smoking. We report a 48-year-old woman with a long-term history of smoking who underwent cadaveric renal transplantation. A renal biopsy to assess a progressive increase in serum creatinine levels 11 years posttransplantation showed features of nodular glomerulosclerosis. Other causes of nodular glomerulosclerosis were excluded. We speculate that long exposure to smoking may be the etiologic factor for nodular glomerulosclerosis in the kidney graft of our patient. Further confirmation of this risk relationship is important because cessation of smoking may help improve renal survival.
authors.affiliation: Department of Internal Medicine, Nephrology Division, University of Iowa Hospitals and Clinics, Iowa City, USA.
authors.forename: Manish
authors.initials: M
authors.lastname: Suneja
authors.forename: Amina
authors.initials: A
authors.lastname: Khan
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Katz
authors.forename: Roberto
authors.initials: R
authors.lastname: Kalil
authors.forename: Ramesh
authors.initials: R
authors.lastname: Nair
mesh_terms: D003404:Creatinine / Q000097:blood; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005921:Glomerulonephritis / Q000601:surgery; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D003404:Creatinine