Effects of collagen iv on cisplatin-induced apoptosis of non-small cell lung cancer cells.
Drug resistance is one of the major causes in treatment failure of non-small cell lung cancer. Interactions between tumor cells and extracellular matrix have been shown to be one of the mechanisms. We investigated the expression of extracellular matrix proteins and the effects of collagen IV on cisplatin-induced apoptosis in cisplatin-sensitive and -resistance lung cancer cells. Extracellular matrix may provide protection against cisplatin-induced apoptosis of lung cancer cells. Integrin β(1) signaling and PI3-Kinase pathway may be important survival pathways of drug-induced apoptosis in lung cancer cells, and activation of this pathway may contribute to the generation of drug resistance.
Su
Chunxia
C
Department of Oncology, Shanghai Pulmonary Hospital of Tongji University, Shanghai, China.
Su
Bo
B
Tang
Liang
L
Zhao
Yinmin
Y
Zhou
Caicun
C
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D017209:Apoptosis / Q000187:drug effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002448:Cell Adhesion; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D024141:Collagen Type IV / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors
D002945:Cisplatin; D024141:Collagen Type IV; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors