title: Ornithine decarboxylase activity as a prognostic marker for colorectal cancer.
abstract: Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435+/-392, 154+/-173, 295+/-202, 103+/-60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (> or =350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery.
authors.affiliation: Department of Surgery I, Fukushima Medical University School of Medicine, Japan. yhoshino@fmu.ac.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Shinya
authors.initials: S
authors.lastname: Terashima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Teranishi
authors.forename: Masanori
authors.initials: M
authors.lastname: Terashima
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kogure
authors.forename: Takuroh
authors.initials: T
authors.lastname: Saitoh
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Osuka
authors.forename: Seigo
authors.initials: S
authors.lastname: Kashimura
authors.forename: Zenichiroh
authors.initials: Z
authors.lastname: Saze
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000236:Adenoma / Q000201:enzymology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D009955:Ornithine Decarboxylase