Neurotoxicity of tryptophan metabolites.
The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
Smith
A J
AJ
Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U.K. a.smith.2@research.gla.ac.uk
Stone
T W
TW
Smith
R A
RA
D000818:Animals; D001921:Brain / Q000187:drug effects*; D006801:Humans; D051379:Mice; D014364:Tryptophan / Q000378:metabolism* / Q000633:toxicity
D014364:Tryptophan