title: Synthesis and antifungal bioactivities of 3-alkylquinazolin- 4-one derivatives.
abstract: A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.
authors.affiliation: Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China. oygp710@163.com
authors.forename: Guiping
authors.initials: G
authors.lastname: Ouyang
authors.forename: Peiquan
authors.initials: P
authors.lastname: Zhang
authors.forename: Gangfang
authors.initials: G
authors.lastname: Xu
authors.forename: Baoan
authors.initials: B
authors.lastname: Song
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D005874:Gibberella / Q000187:drug effects; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D052999:Quinazolinones