Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats.
OBJECTIVE
To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats.


METHODS
20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32 masculine C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation.


RESULTS
Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433).


CONCLUSIONS
Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
Nakano
Hiroshi
H
Division of Neurosurgery, Department of Surgery and Anatomy, Hospital das Clinicas, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, Brazil.
Colli
Benedicto Oscar
BO
Lopes
Luiza da Silva
Lda S
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D007036:Hypothermia, Induced; D002546:Ischemic Attack, Transient / Q000628:therapy*; D013997:Time Factors