title: [Effect of TCM treatment according to syndrome differentiation in enhancing curative effect and reducing side-effect of madopa].
abstract: OBJECTIVE
  To observe the effect of TCM treatment according to syndrome differentiation in en-hancing curative effect and reducing side-effect of madopa in patients with Parkinson' s disease (PD).
  
  
  METHODS
  The trial was conducted in 101 PD patients with a prospective stratified randomized and controlled method. They were assigned to group 1 in which the patients of rigidity were treated with Pabing Recipe 1 (PR1) plus Madopa tablets, group 2 with those of tremor given Pabing Recipe 3 (PR3) plus Madopa tablets, and group 3 given a fixed Chinese recipe plus Madopa tablets as the control. The treatment course for all the groups was 3 months. Clinical efficacy was evaluated with unified Parkinson's disease rating scale (UPDRS) and the adverse reactions observed before and after treatment.
  
  
  RESULTS
  After treatment, the 4 partial scores and the total score of UPDRS decreased significantly in group 2 (P<0.01), and the former of them and the total score declined in group 1 and 3 (P<0.01), the improvement was better in group 1 and 2 than that in group 3 (P<0.01); the improvement rate in group 1 to 3 was 95.5%, 100.0% and 83.7%, respectively, which was significantly higher in group 1 and 2 than that in group 3 (P<0.05).
  
  
  CONCLUSIONS
  TCM treatment according to syndrome differentiation could improve the clinical symptoms and reduce complications in PD patients, which could enhance curative effect and reduce side-effect of madopa.
authors.affiliation: Guangdong Provincial Hospital of Traditional Chi-nese Medicine, Guangdong. fufu69118@yahoo.com.cn
authors.forename: Xin-Fu
authors.initials: XF
authors.lastname: Lian
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001545:Benserazide / Q000009:adverse effects / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D015259:Dopamine Agents / Q000009:adverse effects / Q000627:therapeutic use; D004338:Drug Combinations; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D008517:Phytotherapy; D011446:Prospective Studies; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D015259:Dopamine Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C005177:benserazide, levodopa drug combination; C533629:pabing 1; D007980:Levodopa; D001545:Benserazide