title: Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth.
abstract: OBJECTIVE
  To analyze the association between umbilical cord cardiac troponin I (cTnI), obstetric Doppler, and birth acidemia.
  
  
  METHODS
  This prospective observational study was conducted on 58 singleton pregnancies at 3 Brazilian hospitals. Umbilical and middle cerebral artery Doppler velocimetry were performed 24 h prior to birth. At delivery, cord blood was collected for pH, blood gas analysis, and cTnI measurement.
  
  
  RESULTS
  Cardiac troponin I > or =0.20 ng/mL was detected in 5 neonates (8.6%). Centralization was recorded in 12 fetuses; 4 of these (33.3%) had detectable cTnI compared with 1/46 (2.2%) fetuses with normal Doppler (P=0.005). Acidemia was present in 60% of the neonates with detectable cTnI, compared with 15% of the neonates with undetectable cTnI (P=0.042).
  
  
  CONCLUSIONS
  Centralization and birth acidemia are associated with detectable cTnI in cord blood supporting the possibility of myocardial ischemia in these fetuses.
authors.affiliation: Obstetrics Department, São Paulo Federal University, São Paulo, Brazil. Sandra.Alexandra@ig.com.br
authors.forename: Sandra Maria
authors.initials: SM
authors.lastname: Alexandre
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Ruth
authors.initials: R
authors.lastname: Guinsburg
authors.forename: Mary U
authors.initials: MU
authors.lastname: Nakamura
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Antonio
authors.initials: A
authors.lastname: Moron
mesh_terms: D000138:Acidosis / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*; D016216:Ultrasonography, Prenatal
chemical_list: D019210:Troponin I