The interaction of HIV with dendritic cells: outcomes and pathways.
Dendritic cells (DCs), including Langerhans Cells (LCs), are probably among the earliest targets of HIV infection. Their localization in mucosal epithelia and in the T cell areas of lymphoid organs, as well as their crucial role in capturing antigens and initiating T cell responses, highlight their potential importance. Studies with cells in culture have addressed different outcomes of the HIV--DC interaction, which include: direct productive infection of DC; carriage of virus by DC to CD4+ T cells; transfer of virus between DC and T cells at an infectious synapse; and immune evasion strategies of infected DC. Here we review the literature covering these areas, including current knowledge of underlying mechanisms or pathways.
Piguet
Vincent
V
Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland. vincent.piguet@medecine.unige.ch
Steinman
Ralph M
RM
D017951:Antigen Presentation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D006678:HIV / Q000276:immunology / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D015728:Receptors, HIV / Q000502:physiology; D053586:Virus Internalization
D015728:Receptors, HIV