title: Diterpenoids from the roots of Croton oblongifolius.
abstract: Two new clerodane diterpenes, methyl 15,16-epoxy-3,13(16),14- ENT-clerodatrien-18,19-olide-17-carboxylate ( 1) and dimethyl 15,16-epoxy-12-oxo-3,13(16),14- ENT-clerodatriene-17,18-dicarboxylate ( 2), together with seven known compounds ( 3 - 9), were isolated from the roots of Croton oblongifolius. The isolated compounds showed only mild cytotoxic activity against HuCCA-1, KB, HeLa, MDA-MB231, and T47D cell lines with IC (50) values ranging from 10 to 50 microg/mL.
authors.affiliation: Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand.
authors.forename: Witoon
authors.initials: W
authors.lastname: Youngsa-ad
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojanavanich
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Hunsa
authors.initials: H
authors.lastname: Prawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes