title: A universal biosensing platform based on optical micro-ring resonators.
abstract: The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.
authors.affiliation: Nomadics Inc, Stillwater, OK 74074, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ramachandran
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Clarke
authors.forename: S J
authors.initials: SJ
authors.lastname: Ja
authors.forename: D
authors.initials: D
authors.lastname: Goad
authors.forename: L
authors.initials: L
authors.lastname: Wald
authors.forename: E M
authors.initials: EM
authors.lastname: Flood
authors.forename: E
authors.initials: E
authors.lastname: Knobbe
authors.forename: J V
authors.initials: JV
authors.lastname: Hryniewicz
authors.forename: S T
authors.initials: ST
authors.lastname: Chu
authors.forename: D
authors.initials: D
authors.lastname: Gill
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: O
authors.initials: O
authors.lastname: King
authors.forename: B E
authors.initials: BE
authors.lastname: Little
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D055095:Optics and Photonics / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation* / Q000379:methods; D012031:Refractometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods