Pyrene modification leads to increased catalytic activity in minimal hammerhead ribozymes.
Highly active variants of minimal hammerhead ribozymes are generated by the replacement of substantial parts of stem-loop structures with pyrene building blocks.
Looser
Verena
V
University of Konstanz, Department of Chemistry, Universitätsstr. 10, 78457, Konstanz, Germany.
Langenegger
Simon M
SM
Häner
Robert
R
Hartig
Jörg S
JS
D002384:Catalysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011721:Pyrenes / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D016337:RNA, Catalytic / Q000737:chemistry*
D011721:Pyrenes; D016337:RNA, Catalytic; C427204:hammerhead ribozyme; D012313:RNA