Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage.
Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a central role in necrotic and apoptotic cell death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) epsilon plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCepsilon resides at the mitochondria. Proposed mitochondrial targets of PKCepsilon include mitoK(ATP) (mitochondrial ATP-sensitive K(+) channel), components of the MPTP (mitochondrial permeability transition pore) and components of the electron transport chain. This review highlights mitochondrial targets of PKCepsilon and their possible role in cardioprotective signalling in the setting of ischaemia/reperfusion injury.
Budas
G R
GR
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, U.S.A.
Mochly-Rosen
D
D
D008929:Mitochondria, Heart / Q000201:enzymology*; D017202:Myocardial Ischemia / Q000201:enzymology / Q000517:prevention & control*; D051744:Protein Kinase C-epsilon / Q000378:metabolism*; D015398:Signal Transduction
D051744:Protein Kinase C-epsilon