The regulatory function of plasma-membrane Ca(2+)-ATPase (PMCA) in the heart.
The PMCA (plasma-membrane Ca(2+)-ATPase) is a ubiquitously expressed calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. Unlike in non-excitable cells, where PMCA is the only system for calcium extrusion, in excitable cells, such as cardiomyocytes, PMCA has been shown to play only a minor role in calcium homoeostasis compared with the NCX (sodium/calcium exchanger), another system of calcium extrusion. However, increasing evidence points to an important role for PMCA in signal transduction; of particular interest in cardiac physiology is the modulation of nNOS (neuronal nitric oxide synthase) by isoform 4b of PMCA. In the present paper, we will discuss recent advances that support a key role for PMCA4 in modulating the nitric oxide signalling pathway in the heart.
Oceandy
D
D
Division of Cardiovascular Sciences, University of Manchester, Manchester M13 9PT, U.K.
Stanley
P J
PJ
Cartwright
E J
EJ
Neyses
L
L
D000818:Animals; D030801:Animals, Genetically Modified; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D015398:Signal Transduction
D052248:Nitric Oxide Synthase Type I; D000252:Calcium-Transporting ATPases