Pumping iron: a potential target for novel therapeutics against schistosomes.
Parasites, as with the vast majority of organisms, are dependent on iron. Pathogens must compete directly with the host for this essential trace metal, which is sequestered within host proteins and inorganic chelates. Not surprisingly, pathogenic prokaryotes and eukaryotic parasites have diverse adaptations to exploit host iron resources. How pathogenic bacteria scavenge host iron is well characterized and is reasonably well known for a few parasitic protozoa, but is poorly understood for metazoan parasites. Strategies of iron acquisition by schistosomes are examined here, with emphasis on possible mechanisms of iron absorption from host serum iron transporters or from digested haem. Elucidation of these metabolic mechanisms could lead to the development of new interventions for the control of schistosomiasis and other helminth diseases.
Glanfield
Amber
A
Division of Infectious Diseases and Immunology, The Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia. Amber.Glanfield@qimr.edu.au
McManus
Donald P
DP
Anderson
Greg J
GJ
Jones
Malcolm K
MK
D000818:Animals; D001692:Biological Transport; D006790:Host-Parasite Interactions; D006801:Humans; D007501:Iron / Q000378:metabolism*; D000090463:Iron Deficiencies; D009751:Nutritional Requirements; D012547:Schistosoma / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000378:metabolism / Q000469:parasitology*
D007501:Iron