A novel ansamycin, naphthomycin K from Streptomyces sp.
One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.
Lu
Chunhua
C
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, School of Life Science, Xiamen University, Fujian, PR China.
Shen
Yuemao
Y
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D029755:Maytenus / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D017828:Rifabutin / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D009285:Naphthoquinones; C526004:naphthomycin K; D017828:Rifabutin