title: A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.
abstract: A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Aomori University, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogata
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Midori
authors.initials: M
authors.lastname: Hoshi
authors.forename: Junko
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakashima
authors.forename: Kozue
authors.initials: K
authors.lastname: Anzai
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D025282:Mycelium / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes; D007211:Indoles; C526003:JBIR-03