Acute hepatitis in a patient with familial Mediterranean fever.
Familial Mediterranean fever (FMF) is a hereditary syndrome characterized by recurrent episodes of fever and serositis. In this report, we describe a Japanese patient with FMF and Sjögren's syndrome, in whom acute elevations of transaminase occurred. The histological findings from the liver biopsy specimens demonstrated a nonspecific hepatitis, with liver cell necrosis and interlobular inflammatory cell invasion, without the presence of interface hepatitis or bile duct injury. This case underscores the possibility that MEFV mutations contribute to hepatic inflammation, as seen in this case, by way of an alteration of the pyrin function.
Migita
Kiyoshi
K
Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan. migita@nmc.hosp.go.jp
Abiru
Seigo
S
Tanaka
Mototsugu
M
Ito
Masahiro
M
Miyashita
Taichiro
T
Maeda
Yumi
Y
Koga
Tomohiro
T
Nakamura
Minoru
M
Komori
Atsumasa
A
Yatsuhashi
Hiroshi
H
Ida
Hiroaki
H
Eguchi
Katsumi
K
Hirayama
Kenji
K
Yasunami
Michio
M
Ishibashi
Hiromi
H
D018925:Chemokines / Q000378:metabolism; D003078:Colchicine / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D010505:Familial Mediterranean Fever / Q000150:complications / Q000235:genetics*; D005260:Female; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007564:Japan; D008875:Middle Aged; D000071198:Pyrin
D018925:Chemokines; D016207:Cytokines; D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine