title: Common genetic and environmental influences on major depressive disorder and conduct disorder.
abstract: The evidence for common genetic and environmental influences on conduct disorder (CD) and major depressive disorder (MDD) in adolescents was examined. A sample of 570 monozygotic twin pairs, 592 dizygotic twin pairs, and 426 non-twin siblings, aged 12-18 years, was recruited from the Colorado Twin Registry. For the past year data, there was a significant correlation between the genetic influences on MDD and CD and, for the lifetime data, there was a significant correlation between the genetic influences on MDD and CD, and a significant correlation between the nonshared environmental influences on MDD and CD. Our results suggest that some genetic factors will increase an individual's vulnerability to both MDD and CD in adolescence.
authors.affiliation: Department of Psychology, University of Colorado, Boulder, CO, USA.
authors.forename: Anjali
authors.initials: A
authors.lastname: Subbarao
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Rhee
authors.forename: Susan E
authors.initials: SE
authors.lastname: Young
authors.forename: Marissa A
authors.initials: MA
authors.lastname: Ehringer
authors.forename: Robin P
authors.initials: RP
authors.lastname: Corley
authors.forename: John K
authors.initials: JK
authors.lastname: Hewitt
mesh_terms: D000293:Adolescent; D002648:Child; D015897:Comorbidity; D019955:Conduct Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D012931:Social Environment; D014427:Twins / Q000235:genetics* / Q000523:psychology*