title: Nepafenac-associated corneal melt.
abstract: We describe a patient with systemic graft-versus-host disease who developed a nonhealing epithelial defect after cataract surgery that healed on cessation of a topical nonsteroidal antiinflammatory drug (NSAID) (ketorolac). The patient developed a central corneal perforation in the fellow eye while on a new NSAID formulation (nepafenac) after routine cataract surgery. Our case suggests that new topical NSAIDs may be similar to older NSAID formulations in promoting corneal melting in patients predisposed to poor epithelialization and corneal wound healing.
authors.affiliation: Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. ericwolfmd@yahoo.com
authors.forename: Eric Jay
authors.initials: EJ
authors.lastname: Wolf
authors.forename: Lynda Z
authors.initials: LZ
authors.lastname: Kleiman
authors.forename: Amilia
authors.initials: A
authors.lastname: Schrier
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D044482:Benzeneacetamides / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000601:surgery; D003316:Corneal Diseases / Q000139:chemically induced* / Q000601:surgery; D016039:Corneal Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D008875:Middle Aged; D010648:Phenylacetates / Q000009:adverse effects*; D012422:Rupture, Spontaneous
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac