title: Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma.
abstract: Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.
authors.affiliation: University of California, San Francisco, California 94110, USA.
authors.forename: Mariam
authors.initials: M
authors.lastname: Naqvi
authors.forename: Shannon
authors.initials: S
authors.lastname: Thyne
authors.forename: Shweta
authors.initials: S
authors.lastname: Choudhry
authors.forename: Hui-ju
authors.initials: HJ
authors.lastname: Tsai
authors.forename: Daniel
authors.initials: D
authors.lastname: Navarro
authors.forename: Richard A
authors.initials: RA
authors.lastname: Castro
authors.forename: Sylvette
authors.initials: S
authors.lastname: Nazario
authors.forename: Jose R
authors.initials: JR
authors.lastname: Rodriguez-Santana
authors.forename: Jesus
authors.initials: J
authors.lastname: Casal
authors.forename: Alfonso
authors.initials: A
authors.lastname: Torres
authors.forename: Rocio
authors.initials: R
authors.lastname: Chapela
authors.forename: H Geoffrey
authors.initials: HG
authors.lastname: Watson
authors.forename: Kelley
authors.initials: K
authors.lastname: Meade
authors.forename: Michael
authors.initials: M
authors.lastname: LeNoir
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Avila
authors.forename: William
authors.initials: W
authors.lastname: Rodriguez-Cintron
authors.forename: Esteban González
authors.initials: EG
authors.lastname: Burchard
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000208:ethnology* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008800:Mexico; D009519:New York City; D011647:Puerto Rico; D012495:San Francisco; D018709:Statistics, Nonparametric; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol