title: Crossover interference underlies sex differences in recombination rates.
abstract: In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.
authors.affiliation: Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME 04609, USA. Petko.Petkov@jax.org
authors.forename: Petko M
authors.initials: PM
authors.lastname: Petkov
authors.forename: Karl W
authors.initials: KW
authors.lastname: Broman
authors.forename: Jin P
authors.initials: JP
authors.lastname: Szatkiewicz
authors.forename: Kenneth
authors.initials: K
authors.lastname: Paigen
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic; D005260:Female; D008297:Male; D008540:Meiosis; D051379:Mice; D049471:Pachytene Stage; D011995:Recombination, Genetic; D012727:Sex Characteristics; D012730:Sex Chromosomes