title: Sensitivity of rheoencephalographic measurements to spatial brain electrical conductivity.
abstract: Rheoencephalography (REG) is impedance plethysmography applied to the head, and provides an indirect measurement of the pulsatility of the cerebral blood volume. To extend REG as a clinical and research tool, it is necessary to evaluate the sensitivity of REG measurement to local brain conductivity changes. By means of the analytical solution of a four-sphere geometrical model of the head, maps of impedance sensitivity were assessed for different electrode arrangements. Results showed a selective distribution of sensitivities, with a preference for cortical areas under electrodes. This suggests a potential for application of REG to regional evaluation of cortical cerebral perfusion.
authors.affiliation: Center for Res. & Innovation on Bioeng., Polytech. Valencia Univ., Valencial, Spain. eguijarro@eln.upc.es
authors.forename: Enrique
authors.initials: E
authors.lastname: Guijarro
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Perez
authors.forename: Enrique
authors.initials: E
authors.lastname: Berjano
authors.forename: Pedro
authors.initials: P
authors.lastname: Ortiz
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D004553:Electric Conductivity; D017097:Electric Impedance; D004566:Electrodes; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006257:Head / Q000473:pathology; D006801:Humans; D015233:Models, Statistical; D010477:Perfusion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity