[Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma].
OBJECTIVE
To investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma.


METHODS
Seventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor (VEGF), and the microvessel density (MVD) was determined by immunostaining of the endothelial cells for factor VIII-related antigen (F8).


RESULTS
Positive C-erb B-2 immunostaining was observed in 36.36% (28/77) of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32.48% (25/77). High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD (P<0.05).


CONCLUSIONS
The expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.
Liu
Yi-Min
YM
Department of Oncology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Yang
Guang-Wei
GW
Bai
Shou-Min
SM
Li
Hai-Gang
HG
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000098:blood supply* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
D018719:Erb-b2 Receptor Tyrosine Kinases; D042461:Vascular Endothelial Growth Factor A