[The antiradiation properties of the ecdysteroid-containing compounds].
The antiradiation properties of the ecdysteroid-containing preparations ("serpisten" and inokosterone) are studied under their application before or after the 22.6 cGy chronic low intensity gamma-irradiation of mice. It is shown that the antiradiation of these compounds depend on the dose of preparations and time of the application before or after irradiation of mice. "Serpisten" prevented the decrease of the growth of the body mass of irradiated mice. The normalization of the phospholipid composition of the mice liver and blood erythrocytes for the most investigated parameters revealed under the application of this compound at the dose of 50 mg/kg after the irradiation of animals. The capacity of "serpisten" to decompose of peroxides is shown in vitro. Inokosterone had the certain anabolic properties, caused the normalization of the total peroxidase activity of blood and intensity of the lipid peroxidation (LPO) in brain and in liver, and also the repair of the interrelation between the LPO intensity and catalase activity in the irradiated mice liver. The obtained results allow to conclude that the antiradiation properties of the ecdysteroid-containing preparations under the chronic low intensity irradiation of animals at the low dose due to their capacity to depend on the LPO regulatory system parameters.
Shevchenko
O G
OG
Zagorskaia
N G
NG
Kudiasheva
A G
AG
Shishkina
L N
LN
D000818:Animals; D002782:Cholestenes / Q000494:pharmacology*; D026461:Ecdysteroids / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D009195:Peroxidase / Q000097:blood; D010743:Phospholipids / Q000032:analysis; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D002782:Cholestenes; D026461:Ecdysteroids; D010743:Phospholipids; D011837:Radiation-Protective Agents; C100084:inokosterone; D009195:Peroxidase