[Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system].
OBJECTIVE
To study the acute toxicity of carbon-coated iron nanocrystal (CCIN) in mice and its effects on hepatic, renal and hematological functions.


METHODS
Acute toxicity of CCIN was evaluated by observing the toxic reactions in mice within 14 days following intravenous injection of different doses of CCIN particles. The liver and kidney functions and blood chemistry were tested in rats before and at different time points after CCIN injection.


RESULTS
The median lethal dose (LD(50)) of CCIN particles given by intravenous injection was 203.8 mg /kg in mice. Within the intravenous dose of 80 mg /kg injection, CCIN caused only mild alterations of the rats' biochemical and hematological indices that recovered without intervention in two weeks.


CONCLUSIONS
CCIN is characterized by low acute toxicity and mild side effects on the hepatic, renal and hematological functions within a certain dose range.
Lao
Xiang-Ming
XM
Department of Hepatobiliary Surgery, Cancer Center, Sun Yat-sen University & State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
Zhang
Hai-Yan
HY
Li
Jin-Qing
JQ
Chen
Yi-Ming
YM
Chen
Min-Shan
MS
Yuan
Yun-Fei
YF
Zhang
Ya-Qi
YQ
Zheng
Yun
Y
D000818:Animals; D001774:Blood Chemical Analysis; D002244:Carbon / Q000633:toxicity*; D007501:Iron / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D002244:Carbon; D007501:Iron