Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.
Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia.
Weickert
Cynthia Shannon
CS
MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA. c.shannonweickert@unsw.edu.au
Rothmond
Debora A
DA
Hyde
Thomas M
TM
Kleinman
Joel E
JE
Straub
Richard E
RE
D001345:Autoradiography; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D035061:Control Groups; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D015870:Gene Expression; D014644:Genetic Variation / Q000235:genetics; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D013569:Synapses / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin / Q000235:genetics / Q000378:metabolism; D000099273:Neurabins
D002352:Carrier Proteins; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016708:Synaptophysin; D000099273:Neurabins; C432416:DTNBP1 protein, human