title: Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus.
abstract: Serum concentrations of three angiogenic cytokines: vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1) and placental growth factor (PIGF) and soluble vascular cell adhesion molecule 1 (sVCAM-1), were investigated in the serum of 61 patients with systemic lupus erythematosus (SLE) and 20 healthy subjects. The possible association between serum levels of these proteins and SLE activity, as well as correlation between the concentrations of cytokines were also analysed. All of these factors were detectable in all SLE patients and the healthy control group. The median concentration of VEGF was higher in active SLE (386 pg/mL) than in inactive disease (327 pg/mL) or in the control group (212 pg/mL, p<0.004). The median serum level of SDF-1 was higher in SLE patients (1,814 pg/mL) than in the control group (1,507 pg/mL, p<0.02). The median concentration of PIGF was higher (14 pg/mL) in SLE patients than in the control group (12 pg/mL, p=0.03), and particularly in active disease (17 pg/mL) as compared to the inactive phase (13 pg/mL, p=0.01). The correlations between the levels of cytokines examined and clinical features, laboratory abnormalities and the type of treatment were also analysed. We found a positive correlation between serum concentrations of PIGF and SLE activity according to SLAM score (p=0.33, p=0.13).
authors.affiliation: Department of Dermatology and Venereology, Medical University of Lodz, Lodz, ul. Ciolkowskiego 2, 93-510 Lodz, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Robak
authors.forename: Lilianna
authors.initials: L
authors.lastname: Kulczycka
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jedrzejowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wierzbowska
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
mesh_terms: D000328:Adult; D000368:Aged; D054377:Chemokine CXCL12 / Q000097:blood*; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D011506:Proteins / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D016207:Cytokines; D008565:Membrane Proteins; C098069:PIGF protein, human; D011506:Proteins; D019010:Vascular Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A