Porous composite prosthetic pylon for integration with skin and bone.
This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.
Pitkin
Mark
M
Tufts University, Boston, MA, USA. mpitkin@tufts-nemc.org
Raykhtsaum
Grigory
G
Pilling
John
J
Galibin
Oleg V
OV
Protasov
Mikhail V
MV
Chihovskaya
Julie V
JV
Belyaeva
Irina G
IG
Blinova
Miralda I
MI
Yudintseva
Natalia M
NM
Potokin
Igor L
IL
Pinaev
George P
GP
Moxson
Vladimir
V
Duz
Volodimir
V
D000818:Animals; D008297:Male; D051381:Rats; D000671:Amputation, Surgical; D001186:Artificial Limbs; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000166:cytology / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D008962:Models, Theoretical; D016348:Osseointegration; D016062:Porosity; D011474:Prosthesis Design; D017208:Rats, Wistar; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena