Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy.
BACKGROUND
Mood and anxiety symptoms in chronic hepatitis C (CHC) may be related to the patient awareness of the diagnosis and prognosis, to side effects induced by interferon (IFN)-alpha treatment, as well as to substance abuse. However, the observation of metabolic alterations in patients with CHC has led to hypothesize a direct effect of hepatitis C virus (HCV) on brain function. This study was aimed at elucidating whether CHC is associated with specific anxiety or mood disorders independently of confounding factors.


METHODS
Patient cohort: consecutive patients, 135 with CHC and 76 with chronic hepatitis B (CHB).


METHODS
previous treatment with IFN-alpha, co-infection with HCV and hepatitis B virus, infection with human immunodeficiency virus, drug or alcohol abuse, or malignancies.


METHODS
subjects without evidence of hepatitis randomly extracted from the database of a previous epidemiological study; they were divided into two groups of 540 (332 males) and 304 (220 males) as controls for patients with CHC and CHB, respectively. The psychiatric diagnosis was formulated by means of the Composite International Diagnostic Interview Simplified carried out by a physician according to DSM-IV criteria.


RESULTS
A higher lifetime prevalence of major depressive disorder (MDD) was observed among CHC compared to CHB or controls. The risk of MDD was not statistically different between CHB and controls. Both the CHC and CHB groups showed a significantly higher frequency of panic disorder when compared to controls. No statistical differences were observed in the prevalence of general anxiety disorder and social phobia when CHC or CHB were compared to controls.


CONCLUSIONS
The present study provides the first evidence of an association between CHC and MDD, diagnosed on the basis of well-defined international criteria. This association is independent of treatment with IFN-alpha and is not influenced by substance or alcohol abuse. By contrast, anxiety disorders do not appear to be specifically associated with CHC.
Carta
Mauro G
MG
Department of Public Health, University of Cagliari, Italy. mgcarta@tiscali.it.
Hardoy
Maria Carolina
MC
Garofalo
Alessandra
A
Pisano
Enrica
E
Nonnoi
Valentina
V
Intilla
Gesuina
G
Serra
Giancarlo
G
Balestrieri
Cinzia
C
Chessa
Luchino
L
Cauli
Cristiana
C
Lai
Maria Eliana
ME
Farci
Patrizia
P