title: Determinants of outcome in critically ill octogenarians after surgery: an observational study.
abstract: BACKGROUND
  The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery.
  
  
  METHODS
  We identified 275 patients, aged 80 yr or greater, admitted to the ICU after surgery. After exclusions, 255 were selected for further analysis. Multivariate analysis was then performed to determine the covariates associated with hospital mortality.
  
  
  RESULTS
  The overall ICU and hospital mortality was 20.4% and 33.3%, respectively. Patients who received i.v. vasoactive drugs on days 1 and 2 had hospital mortality of 54.4% and 60.5%, respectively. Multivariate analysis showed that requirement for i.v. vasoactive drugs within the first 24 h on ICU [odds ratio (OR) 4.29; 95% CI, 2.35-7.84, P<0.001] and requirement for i.v. vasoactive drugs for a further 24 h (OR 3.63; 95% CI, 1.58-8.37, P<0.01) were associated with hospital mortality. The requirement for i.v. vasoactive drugs was also strongly associated with hospital mortality in all the subgroups studied (elective surgery, emergency surgery, and emergency laparotomy).
  
  
  CONCLUSIONS
  For patients aged 80 yr and more, admitted to ICU after surgery, the requirement for i.v. vasoactive drugs in the first and second 24 h was the strongest predictor of hospital mortality.
authors.affiliation: Department of Anaesthesia, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK. fordpeter@doctors.org.net
authors.forename: P N R
authors.initials: PN
authors.lastname: Ford
authors.forename: I
authors.initials: I
authors.lastname: Thomas
authors.forename: T M
authors.initials: TM
authors.lastname: Cook
authors.forename: E
authors.initials: E
authors.lastname: Whitley
authors.forename: C J
authors.initials: CJ
authors.lastname: Peden
mesh_terms: D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000008:administration & dosage; D016638:Critical Illness / Q000401:mortality*; D004334:Drug Administration Schedule; D004739:England / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000401:mortality*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents