Treatment of trigeminal neuralgia with low doses of topiramate.
Topiramate was administered to eight patients with classical trigeminal neuralgia with or without previous symptomatic therapy with other antiepileptic drugs. The topiramate doses ranged from 50 to 100 mg a day, according to the clinical response and the reported side effects. Three patients had complete symptoms remission, three reported moderate improvement, and the treatment was not effective in two. The most frequently registered side effects were dizziness, somnolence and weight loss. Topiramate can be considered an alternative treatment for patients with trigeminal neuralgia.
Domingues
Renan Barros
RB
Departamento de Patologia, Escola Superior de Ciências, Santa Casa de Misericórdia de Vitória, Avenida Nossa Senhora da penha 699, 29055-131 Vitória, ES, Brazil. renan-domingues@uol.com.br
Kuster
Gustavo Wruck
GW
Aquino
Camila Catherine Henriques
CC
D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077236:Topiramate; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000188:drug therapy*
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose