Short-term effects of sleeve gastrectomy on type 2 diabetes mellitus in severely obese subjects.
BACKGROUND
Data on the effectiveness of sleeve gastrectomy (SG) in improving or resolving type 2 diabetes mellitus (T2DM) are scarce.


METHODS
A 4-month prospective study was conducted on the changes in glucose homeostasis in 35 severely obese T2DM subjects undergoing laparoscopic SG (LSG) and 50 subjects undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP), matched for DM duration, type of DM treatment, and glycemic control.


RESULTS
At 4-months after surgery, LSG and LRYGBP operated subjects lost a similar amount of weight (respectively, 20.6 +/- 0.7% and 21.0 +/- 0.6%). T2DM had resolved respectively in 51.4% and 62.0% of the LSG and LRYGBP operated subjects (P = 0.332). A shorter preoperative DM duration (P < 0.05), a preoperative DM treatment not including pharmacological agents, and a better pre-surgical fasting plasma glucose (P < 0.01) or HbAlc (P < 0.01), were significantly associated with a better type 2 DM outcome in both surgical groups.


CONCLUSIONS
Our data show that LSG and LRYGBP result in a similar rate of type 2 DM resolution at 4-months after surgery. Moreover, our data suggest that mechanisms beyond weight loss may be implicated in DM resolution following LSG and LRYGBP.
Vidal
J
J
Obesity Unit, Hospital Clínic Universitari, Barcelona, Spain. jovidal@clinic.ub.es
Ibarzabal
A
A
Nicolau
J
J
Vidov
M
M
Delgado
S
S
Martinez
G
G
Balust
J
J
Morinigo
R
R
Lacy
A
A
D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D012074:Remission Induction