[The usefulness of calcium and vitamin D supplementation after the Women's Health Initiative trial].
Three recently published randomized controlled studies on the effects of calcium and vitamin D on fracture risk from the UK and the USA were critically reviewed. We found problems related to their external validity compromising their transferability to Denmark. Furthermore, study power was limited because of the selection of low-risk patients, problems with compliance and persistence, and supplementation with calcium and vitamin D outside the protocol. Two recent meta-analyses including the three studies supported the continuous use of calcium and vitamin D to prevent fractures in the elderly.
Mosekilde
Leif
L
Arhus Sygehus, Medicinsk-endokrinologisk Afdeling C, Arhus C. leif.mosekilde@as.aaa.dk
Langdahl
Bente Lomholt
BL
Nielsen
Lars Rejnmark
LR
Vestergaard
Peter
P
D000368:Aged; D002118:Calcium / Q000008:administration & dosage*; D019317:Evidence-Based Medicine; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage*; D016387:Women's Health
D014807:Vitamin D; D002118:Calcium