Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib.
The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.
Knesl
Petr
P
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria.
Röseling
Dirk
D
Jordis
Ulrich
U
D002851:Chromatography, High Pressure Liquid; D000069347:Erlotinib Hydrochloride; D000077156:Gefitinib; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000138:chemical synthesis*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis*; D011799:Quinazolines / Q000138:chemical synthesis*
D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; C464670:tandutinib; D000077156:Gefitinib