title: Volumetric intravascular ultrasound imaging to illustrate the extent of coronary plaque burden in type 2 diabetic patients.
abstract: BACKGROUND
  Although angiography is the gold standard for coronary imaging, its efficacy in outlining diffuse coronary atherosclerosis in diabetic patients remains questionable. We aimed to compare quantitative cineangiographic analysis (QCA) with three-dimensional intravascular ultrasound (IVUS) imaging in type 2 diabetic patients with coronary artery disease.
  
  
  METHODS
  IVUS runs of 104 significant coronary lesions in 88 diabetic patients were performed. Arterial remodeling index was calculated as vessel area at minimal lumen area divided by mean reference vessel area.
  
  
  RESULTS
  No difference between the two analysis modes was shown for lesion length and minimal lumen diameter, whereas a significant discrepancy between QCA and IVUS was found for diameter stenosis (10 +/- 9% vs. 41 +/- 8%; P<.001) and vessel diameter (3.01 +/- 0.66 vs. 4.53 +/- 0.70 mm; P<.001). A significant difference on arterial remodeling at lesion site was found between insulin-treated diabetic patients and non-insulin-treated diabetic patients (remodeling index: 0.98 +/- 0.16 vs. 1.07 +/- 0.21; P=.04).
  
  
  CONCLUSIONS
  Coronary angiographic diagnosis in diabetic patients may be distorted due to a large plaque burden over longer vessel segments and the resulting absence of plaque-free reference segments. This distortion was found to be more pronounced in QCA analysis requiring a reference diameter, whereas volumetric IVUS imaging illustrated coronary artery dimensions more accurately according to anatomic structures. Constrictive arterial remodeling was observed more frequently in type 2 diabetic patients treated with insulin.
authors.affiliation: Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. christoph.schukro@meduniwien.ac.at
authors.forename: Christoph
authors.initials: C
authors.lastname: Schukro
authors.forename: Bonni
authors.initials: B
authors.lastname: Syeda
authors.forename: Nabil
authors.initials: N
authors.lastname: Yahya
authors.forename: Alois
authors.initials: A
authors.lastname: Gessl
authors.forename: Erik W
authors.initials: EW
authors.lastname: Holy
authors.forename: Philipp
authors.initials: P
authors.lastname: Pichler
authors.forename: Michael
authors.initials: M
authors.lastname: Derntl
authors.forename: Dietmar
authors.initials: D
authors.lastname: Glogar
mesh_terms: D000368:Aged; D000465:Algorithms; D015906:Angioplasty, Balloon, Coronary; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D015992:Body Mass Index; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking; D016540:Smoking Cessation; D018084:Ultrasonography, Interventional