title: Childhood ALL and second neoplasms.
abstract: Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation. Brain tumors, most commonly meningiomas, are among the most common second neoplasms discovered in these patients. Breast cancer can occur in association with meningioma, but is not thought to be a consequence of treatment for childhood ALL. We describe the molecular genetics and therapy of childhood ALL, the molecular genetics of meningioma, as well as the possible association between meningioma and breast cancer.
authors.affiliation: Department of Medicine (Hematology/Oncology), Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Tapan N
authors.initials: TN
authors.lastname: Maniar
authors.forename: Inbal
authors.initials: I
authors.lastname: Braunstein
authors.forename: Stephen
authors.initials: S
authors.lastname: Keefe
authors.forename: Sofia
authors.initials: S
authors.lastname: Hussen
authors.forename: Tara
authors.initials: T
authors.lastname: Abrams
authors.forename: Angela
authors.initials: A
authors.lastname: De Michele
authors.forename: Wafik S
authors.initials: WS
authors.lastname: El-Deiry
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D008579:Meningioma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D012306:Risk