title: [Consequences of premature rupture of the membranes in the perinatal lung].
abstract: Early premature rapture of the membranes (PROM) during pregnancy is associated with a high risk of perinatal morbidity and mortality. Early PROM impairs lung structures and function through 3 mechanisms : 1) oligo-hydramnios ; 2) fetal inflammatory syndrome ; and 3) prematurity. Thus, the related causes of respiratory failure at birth after PROM are: hyaline membrane disease, persistent pulmonary hypertension induced by impaired endothelial function and/or lung hypoplasia, materno-fetal infection, and bronchopulmonary dysplasia resulting at least in part from the fetal inflammatory syndrome. Severity of the respiratory morbidity is largely unpredictable. Even if gestational age at PROM is considered as a prognostic factor, survival without morbidity exist after PROM as early as 18 weeks GA. Better knowledge of the pathophysiology improved the outcome of the preterm infants born after early PROM. Optimal management of the respiratory failure including minimizing barotrauma is required to prevent from bronchopulmonary dysplasia.
authors.affiliation: Pôle de médecine périnatale, hôpital Jeanne-de-Flandre, CHRU de Lille, JE 2490, faculté de Médecine, Université de Lille Il, Lille, France. lstorme@chru-lille.fr
authors.forename: L
authors.initials: L
authors.lastname: Storme
authors.forename: T
authors.initials: T
authors.lastname: Rakza
authors.forename: V
authors.initials: V
authors.lastname: Houfflin-Debarge
authors.forename: P
authors.initials: P
authors.lastname: Dufour
authors.forename: A
authors.initials: A
authors.lastname: Bouissou
authors.forename: D
authors.initials: D
authors.lastname: Subtil
authors.forename: P
authors.initials: P
authors.lastname: Deruelle
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology* / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000209:etiology / Q000628:therapy; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D016104:Oligohydramnios / Q000503:physiopathology; D010547:Persistent Fetal Circulation Syndrome / Q000209:etiology* / Q000628:therapy; D011247:Pregnancy; D011379:Prognosis; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology