title: Comparison of intraoperative ultrasound with postimplant computed tomography--dosimetric values at Day 1 and Day 30 after prostate brachytherapy.
abstract: OBJECTIVE
  To compare the results of intraoperative dosimetry with those of postimplant computed tomography (CT)-based dosimetry after (125)I prostate brachytherapy.
  
  
  METHODS
  We treated 412 prostate cancer patients with (125)I prostate brachytherapy, with or without external beam radiotherapy at our institution. Neoadjuvant hormone therapy was administered to 331 patients (80.3%). Implantation was performed using an intraoperative interactive technique. Postimplant dosimetry was performed on Day 1 and Day 30 using CT imaging. The dosimetric results for the prostate, urethra, and rectum were compared among intraoperative ultrasound, and CT scans of Day 1 and Day 30.
  
  
  RESULTS
  The mean intraoperative minimal dose received by 90% of the prostate volume (D(90)) was 118.8% of the prescribed dose vs. 106.4% for Day 1 (p < 0.01) and 119.2% for Day 30 (p = 0.25). There were no significant correlations between the intraoperative D(90) and the postimplant D(90) values (intraclass correlation coefficients=0.42 and 0.33 for Day 1 and Day 30, respectively). Prostatic edema at Day 1 had the largest effect on the Day 1 D(90) (p < 0.01). The factor significantly affecting the Day 30 D(90) was neoadjuvant hormone therapy (p < 0.01). The mean Day 30 D(90) for the hormone-treated patients was 117.9%, compared with 124.6% for those who remained hormone naïve. The intraoperative and postimplant dosimetric values differed significantly for the urethra and rectum.
  
  
  CONCLUSIONS
  Our results demonstrate that there are no significant differences between the D(90) assessments obtained intraoperatively and at Day 30 postoperatively. Furthermore, there are no definite correlations between intra- and postimplantation dosimetric values. Other D(90) values differed significantly between the intraoperative and postimplant dosimetry. This study suggests that dosimetry has negligible clinical utility for informing patients, at discharge, of whether or not their implants are adequate.
authors.affiliation: Department of Radiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan. ohasi@rad.med.keio.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohashi
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yorozu
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Toya
authors.forename: Shiro
authors.initials: S
authors.lastname: Saito
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Momma
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Nagata
authors.forename: Michio
authors.initials: M
authors.lastname: Kosugi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Shigematsu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011467:Prostate / Q000000981:diagnostic imaging*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012007:Rectum / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014521:Urethra / Q000000981:diagnostic imaging
chemical_list: D000726:Androgen Antagonists; D007457:Iodine Radioisotopes; D007987:Gonadotropin-Releasing Hormone