Molecules that target beta-amyloid.
The devastating effects of Alzheimer's and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta-amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact with either oligomeric or fibrillar forms of the beta-amyloid peptide. We describe natural proteins, peptides, peptidomimetics, and small molecules that have been found to interfere with beta-amyloid aggregation. We also detail recent efforts in selecting molecules that target beta-amyloid isolated from antibody, protein, and peptide libraries. These new molecules will likely aid in deciphering the details of the aggregation pathway for the beta-amyloid peptide and provide reagents that may stabilize relevant oligomeric intermediates which likely have bearing on the pathophysiology of Alzheimer's disease. Moreover, the described anti-amyloid molecular toolbox will also provide an avenue for designing new diagnostic and therapeutic reagents.
Stains
Cliff I
CI
Department of Chemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA.
Mondal
Kalyani
K
Ghosh
Indraneel
I
D016229:Amyloid beta-Peptides / Q000187:drug effects*; D000686:Amyloidosis / Q000188:drug therapy / Q000628:therapy; D000818:Animals; D001921:Brain / Q000473:pathology; D006801:Humans; D007167:Immunotherapy; D018716:Molecular Mimicry; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use
D016229:Amyloid beta-Peptides; D010455:Peptides