title: [Clinical study on effect of Shenyin Oral Liquid in treating mild cognitive impairment].
abstract: OBJECTIVE
  To observe the therapeutic effect of Shenyin Oral Liquid (SOL) in relieving mild cognitive impairment (MCI) and decreasing the Alzheimer's disease (AD) transformation rate.
  
  
  METHODS
  One hundred and seventeen MCI patients were randomly assigned to the Chinese medicine group (42 cases), the vitamin E group (38 cases) and the placebo group (37 cases). The treatment course was 12 months and a 6-month follow-up was conducted after ending the treatment course.
  
  
  RESULTS
  After treatment, the scores of clock drawing test (CDT), nonsensical figure recognition and mini-mental state examination (MMSE) raised significantly in the Chinese medicine group (P < 0.05 or P < 0.01), the activity of acetylcholine esterase in erythrocytic membrane was lower in the Chinese medicine group than that in the placebo group and the Vitamin E group (P < 0.05 or P < 0.01). Six months after the treatment, there were 2 and 5 cases in the placebo group and the vitamin E group which were diagnosed as AD, respectively, and none in the Chinese medicine group.
  
  
  CONCLUSIONS
  SOL has an effect similar to cholinesterase inhibitor, it could improve cognitive function in MCI patients and reduce the AD transformation rate in them.
authors.affiliation: Shanghai Geriatric Institute of Chinese Medicine, Shanghai. SGI-tcm@sohu.com
authors.forename: Ru-Qian
authors.initials: RQ
authors.lastname: Zhou
authors.forename: Shui-Miao
authors.initials: SM
authors.lastname: Lin
authors.forename: Quan
authors.initials: Q
authors.lastname: Yuan
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000517:prevention & control*; D003072:Cognition Disorders / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008609:Mental Status Schedule; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use; D008517:Phytotherapy; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D018697:Nootropic Agents; C533628:shenyin