Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a variety of adverse effects on cell signaling leading to suppression of cytokine expression and induction of programmed cell death. A comparative in vitro study with Y. pestis and Y. enterocolitica O:8 virulent strains shows some critical disparity in YopJ/YopP-related effects on immune cells. Involvement of yopJ in virulence was evaluated in mouse model of bubonic plague.
Zauberman
Ayelet
A
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona.
Velan
Baruch
B
Mamroud
Emanuelle
E
Flashner
Yehuda
Y
Shafferman
Avigdor
A
Cohen
Sara
S
D017209:Apoptosis; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D005798:Genes, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D013045:Species Specificity; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D015008:Yersinia enterocolitica / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D015010:Yersinia pestis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*
D001426:Bacterial Proteins; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C109227:YopP protein, Yersinia