The influence of hydrosalpinx on markers of endometrial receptivity.
Hydrosalpinx is a common condition among women of reproductive age. It is related to low pregnancy rates in the settings of in vitro fertilization-embryo transfer programs. Such low rates are not yet well understood, and may be due to poor endometrial receptivity and abnormal expression of key molecules in the endometrium that are important for implantation. The available data on the inflammatory response, endometrial blood flow, integrins, leukemia inhibitory factor, matrix metalloproteinases, and homeobox gene A10 expression in the presence of hydrosalpinx are reviewed. In addition, the evidence for treatment options to improve pregnancy rates is also discussed.
Savaris
Ricardo Francalacci
RF
Departamento de Ginecologia e Obstetricia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. rsavaris@hcpa.ufrgs.br
Giudice
Linda C
LC
D015415:Biomarkers / Q000378:metabolism*; D010064:Embryo Implantation; D004717:Endometrium / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D005184:Fallopian Tube Diseases / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005307:Fertilization in Vitro; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D053605:Leukemia Inhibitory Factor / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011247:Pregnancy; D012039:Regional Blood Flow; D016896:Treatment Outcome
D015415:Biomarkers; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins; D018836:Inflammation Mediators; D016023:Integrins; D053605:Leukemia Inhibitory Factor; C092119:Hoxa10 protein, mouse; D020782:Matrix Metalloproteinases