[The influence of chemical inhibitors of DNA repair on the recovery of mammalian cell damages induced by ionizing radiation].
Using experimental results published by other authors the irreversible component of radiation damage and recovery constant, characterized the probability of recovery of mammalian cells of various origin from radiation damages per unit time, have been calculated. It was shown that the inhibition of postirradiation recovery, displayed in the decreasing of both the rate and the volume of recovery, has occurred due to the increasing in the portion of radiation damages from which the cell is incapable to recover. At the same time the recovery constant was independent on the conditions of combined action in the most cases, being decreasing in small extent only for hydroxyurea and 3-aminobenzamide. It was concluded that the inhibition of recovery is not the main reason of chemical radiosensibilization, but is a quite expected consequence of the increase in the portion of irreversibly damaged cells.
Komarova
L N
LN
Tkhabisimova
M D
MD
Petin
V G
VG
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014965:X-Rays
D001549:Benzamides; D011838:Radiation-Sensitizing Agents; C025160:3-aminobenzamide; D006918:Hydroxyurea