title: Neoadjuvant therapy followed by prostatectomy for clinically localized prostate cancer.
abstract: The results of this assessment of the literature indicated that neoadjuvant therapy followed by prostatectomy may improve long-term outcomes for patients with high-risk localized disease. In addition, this approach provides a paradigm for evaluating the activity and mechanism of action of new agents as correlative studies are facilitated by the availability of tumor tissue before and after therapy. The authors determined that a multidisciplinary approach involving oncologists, urologists, and pathologists is critical to the success of this model. Recent and ongoing studies of neoadjuvant therapy followed by prostatectomy were reviewed.
authors.affiliation: Genitourinary Oncology Program, U.S. Oncology Research, Houston, Texas, USA. guru.sonpavde@usoncology.com
authors.forename: Guru
authors.initials: G
authors.lastname: Sonpavde
authors.forename: Kim N
authors.initials: KN
authors.lastname: Chi
authors.forename: Thomas
authors.initials: T
authors.lastname: Powles
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Sweeney
authors.forename: Noah
authors.initials: N
authors.lastname: Hahn
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Hutson
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Galsky
authors.forename: William R
authors.initials: WR
authors.lastname: Berry
authors.forename: Dov
authors.initials: D
authors.lastname: Kadmon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal