Sex differences in pediatric bipolar disorder.
OBJECTIVE
To explore sex differences in pediatric bipolar disorder in terms of subtype and severity of depressive and manic symptomatology.


METHODS
Participants were 760 youth (aged 5-17 years) and their legal guardians. Participants were part of a larger outpatient assessment protocol enriched for bipolar disorder. Youth were assessed for DSM-IV diagnoses using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version. Their presenting mood state was determined using the Young Mania Rating Scale and the Children's Depression Rating Scale-Revised. The study was conducted from January 1996 to February 2003.


RESULTS
387 youth (51%) met DSM-IV criteria for diagnoses of bipolar spectrum disorders. Results showed no sex differences in rates of bipolar spectrum disorders or any of the bipolar subtypes. Sex differences were found with regard to presenting mood states: boys presented with higher rates of manic mood, and girls presented with higher rates of depressed mood. Older children were also more likely than younger children to exhibit higher levels of depressed mood. There were no age differences in levels of manic mood.


CONCLUSIONS
This study highlights how bipolar disorder can manifest itself differently among girls and boys despite equivalent rates of diagnosis. It is important for clinicians to consider the full range of mood states in order to accurately diagnose and treat children. Future research is needed to assess the roles that genetics, puberty, cognitive styles, and environmental factors play in the expression of mania and depression in girls and boys over the course of their development.
Duax
Jeanne M
JM
Department of Psychology, Case Western Reserve University, Cleveland, OH 44106-7123, USA. jeanne.duax@case.edu
Youngstrom
Eric A
EA
Calabrese
Joseph R
JR
Findling
Robert L
RL
D000293:Adolescent; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D012649:Self Concept; D012737:Sex Factors; D012951:Socialization; D014705:Verbal Behavior