Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: a review.
Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye drops account for more than 90% of all ophthalmic formulations. The bioavailability of ophthalmic drugs can be improved by a soft contact lens-based ophthalmic drug delivery system. Several polymeric hydrogels have been investigated for soft contact lens-based ophthalmic drug delivery systems: (i) polymeric hydrogels for conventional contact lens to absorb and release ophthalmic drugs; (ii) polymeric hydrogels for piggyback contact lens combining with a drug plate or drug solution; (iii) surface-modified polymeric hydrogels to immobilize drugs on the surface of contact lenses; (iv) polymeric hydrogels for inclusion of drugs in a colloidal structure dispersed in the lens; (v) ion ligand-containing polymeric hydrogels; (vi) molecularly imprinted polymeric hydrogels which provide the contact lens with a high affinity and selectivity for a given drug. Polymeric hydrogels for these contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.
Xinming
Li
L
Department of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Technology, No. 24 Dongsha Street, Fangzhi Road, Haizhu District, Guangzhou 510225, Guangdong, PR China. lixinming@sina.com
Yingde
Cui
C
Lloyd
Andrew W
AW
Mikhalovsky
Sergey V
SV
Sandeman
Susan R
SR
Howel
Carol A
CA
Liewen
Liao
L
D003261:Contact Lenses; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004343:Drug Implants / Q000008:administration & dosage / Q000737:chemistry*; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000008:administration & dosage*
D004337:Drug Carriers; D004343:Drug Implants; D020100:Hydrogels; D009883:Ophthalmic Solutions