[Effects and mechanisms of shidi capsule on adjuvant arthritis model].
OBJECTIVE
To probe into the effects and mechanisms of Shidi capsule on adjuvant arthritis model (AA).


METHODS
SD rats, maleness, were stochastically divided into the normal comparison, the model, the dexamethasone (0.45 mg kg(-1)), total glucosides of paeony (150 mg kg(-1)) and Shidi capsule (gruffs) high (5400 mg kg(-1)), middle (2700 mg kg(-1)) and low (1350 mg kg(-1)) dose groups. Except the normal comparison group, rats in the other groups were injected Freund's complete adjuvant reagent into the rat' right metapedes to establish the AA model. Drugs were given by intragastric administration. Then paw swelling, the content of prostaglandin E2 in inflamed paws, MDA and SOD in blood serum, the spleen and thoracic gland index, and histopathology change of malleolus joint were observed.


RESULTS
The Shidi high, middle and low dose groups could inhibit the primary and secondary swelling of the rats' inflamed metapedes in a dose-dependent manner. Compared with the model group, each group of Shidi capsule could increase SOD,decrease MDA and PGE2, advance the spleen, and thoracic gland index, and relive the histopathology change of malleolus joint.


CONCLUSIONS
Shidi capsule could inhibit the inflammation of synovial membrane obviously, relieve the degree of injury of cell, and therefore have therapeutic efficacy to AA rats.
Zhang
Ge
G
Department of Physiology, Pharmacy College, China Pharmaceutical University, Nanjing 210009, China.
Wu
Yu-lin
YL
Shen
Lei
L
Wang
Mei
M
Ji
Rui
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology*; D002214:Capsules; D015232:Dinoprostone / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013640:Tarsal Joints / Q000473:pathology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D015232:Dinoprostone