title: Drug removal by plasmapheresis: an evidence-based review.
abstract: Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications-mostly case reports of overdoses-have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.
authors.affiliation: Department of Pharmacy, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201-2013, USA. ibrahim@Karmanos.org
authors.forename: Rami B
authors.initials: RB
authors.lastname: Ibrahim
authors.forename: Chin
authors.initials: C
authors.lastname: Liu
authors.forename: Simon M
authors.initials: SM
authors.lastname: Cronin
authors.forename: Bridgette C
authors.initials: BC
authors.lastname: Murphy
authors.forename: Raymond
authors.initials: R
authors.lastname: Cha
authors.forename: Paul
authors.initials: P
authors.lastname: Swerdlow
authors.forename: David J
authors.initials: DJ
authors.lastname: Edwards
mesh_terms: D062787:Drug Overdose / Q000628:therapy; D019317:Evidence-Based Medicine; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D010951:Plasma Exchange / Q000379:methods*; D010956:Plasmapheresis / Q000379:methods*; D011041:Poisoning / Q000628:therapy*
chemical_list: D004364:Pharmaceutical Preparations