title: Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones.
abstract: A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Alireza
authors.initials: A
authors.lastname: Samzadeh-Kermani
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Dehghan
authors.forename: Maedeh
authors.initials: M
authors.lastname: Sorkhi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Arabsorkhi
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Heidari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010851:Picrates; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001597:Benzylidene Compounds; D001713:Biphenyl Compounds; D002839:Chromans; D005290:Ferric Compounds; D005609:Free Radicals; D006834:Hydrazines; D008055:Lipids; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid