title: Microwave-assisted Suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites.
abstract: A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to approximately 24 h under thermal conditions, corresponding to a approximately 72-fold increase in reaction rate.
authors.affiliation: Department of Pharmacology, Chemical Carcinogenesis and Chemoprevention Program of Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA. aks14@psu.edu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Sharma
authors.forename: Krishnegowda
authors.initials: K
authors.lastname: Gowdahalli
authors.forename: Jacek
authors.initials: J
authors.lastname: Krzeminski
authors.forename: Shantu
authors.initials: S
authors.lastname: Amin
mesh_terms: D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D013237:Stereoisomerism
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons