[The effects of low doses of low-level gamma-radiation and phenozan injection on structural characteristics of mice spleen DNA].
It is well known that AKR mice with spontaneous leucosis are more sensitive to ionizing irradiation as compared to normal F1 (CBA x C57BL) mice. A study on changes of the structural characteristics of spleen DNA and level of protein p53 in the blood serum under the action of low-level gamma-irradiation in a dose of 1.2 cGy and injections of 10(-14) or 10(-4) mol/kg phenozan was performed. The changes in the structural characteristics of DNA (the adsorption on nitrocellulose filters and number of double-strand breaks) and p53 content were observed for each line of mice under gamma-irradiation and each phenozan concentration. Both factors showed long-time post-effects, and structural changes in AKR DNA were consistent with the life span of these mice. Phenozan in the above doses has abolished the induction of double-strand breaks in case of irradiation of F1 mice in a dose of 1.2 cGy and showed long-time post-irradiation effect. These facts suggest a radioprotection property of phenozan.
Zhizhina
G P
GP
Zavarykina
T M
TM
Mil'
E M
EM
Burlakova
E B
EB
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects; D053903:DNA Breaks, Double-Stranded; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D007953:Leukemia, Radiation-Induced / Q000235:genetics* / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D010666:Phenylpropionates / Q000008:administration & dosage*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000097:blood
D000975:Antioxidants; D010666:Phenylpropionates; D016159:Tumor Suppressor Protein p53; D004247:DNA; C047854:fenozan