Enantioselective synthesis and vanilloid activity evaluation of 1-beta-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks.
A simple strategy is outlined for preparation of the antinociceptive 1-beta-(p-methoxycinnamoyl)polygodial, isolated from Drymis winteri barks. The synthesized compound showed vanilloid activity.
Della Monica
Carmela
C
Dipartimento di Chimica, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
De Petrocellis
Luciano
L
Di Marzo
Vincenzo
V
Landi
Raffaella
R
Izzo
Irene
I
Spinella
Aldo
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000302:isolation & purification; D002460:Cell Line; D032424:Drimys; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000138:chemical synthesis / Q000302:isolation & purification; D013237:Stereoisomerism; D050916:TRPV Cation Channels / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism*
D000700:Analgesics; D010936:Plant Extracts; D050916:TRPV Cation Channels