A comparative study of CYP3A4 polymorphisms in Mexican Amerindian and Mestizo populations.
Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism of approximately half the drugs in clinical use today. The aim of the present study was to determine the frequency of the CYP3A4*1B, *2, *4, *5, and *18 alleles amongst both Tepehuan Amerindians, a native group that has inhabited northern Mexico for thousands of years, and Mestizo Mexicans, and to compare the data with those of other populations. Genotyping experiments revealed that 8.8 and 8.0% of the Mestizo and Tepehuano subjects, respectively, carried the CYP3A4*1B allele. Only one Mestizo subject was heterozygous for the CYP3A4*2 variant, while CYP3A4*4, *5 and *18 allelic variants were not detected in either group. On the other hand, the frequencies of the CYP3A4*1B variant in Mestizos and Tepehuanos were similar to those reported for Caucasians, but different from those observed for African and Asian populations.
Reyes-Hernández
Octavio D
OD
Sección de Toxicología, CINVESTAV-IPN, México, México.
Lares-Asseff
Ismael
I
Sosa-Macias
Martha
M
Vega
Libia
L
Albores
Arnulfo
A
Elizondo
Guillermo
G
D000293:Adolescent; D000328:Adult; D000349:Africa; D000368:Aged; D001208:Asia; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009656:North America; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People
D003577:Cytochrome P-450 Enzyme System; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human