Asymmetric organocatalytic reductions mediated by dihydropyridines.
Catalytic asymmetric reduction reactions have long been the preserve of the transition metal catalyst. Inspired by the myriad efficient enzyme-catalysed reduction reactions routine in biological systems, chemists have recently begun to design chiral metal-free organocatalysts that employ synthetic dihydropyridine NADH analogues as the hydride source with impressive results. Recent developments in this burgeoning field are discussed.
Connon
Stephen J
SJ
Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland. connons@tcd.ie
D002384:Catalysis; D004095:Dihydropyridines / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
D004095:Dihydropyridines; D009930:Organic Chemicals; D013890:Thiourea