Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.
There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.
Rashid
Asim J
AJ
Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
O'Dowd
Brian F
BF
Verma
Vaneeta
V
George
Susan R
SR
D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000819:agonists / Q000378:metabolism / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects
D017447:Receptors, Dopamine D1; D043562:Receptors, G-Protein-Coupled; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D004298:Dopamine