title: Applicability of current bovine spongiform encephalopathy (BSE) diagnostic procedures for chronic wasting disease (CWD).
abstract: Chronic wasting disease (CWD) in cervids is one of the transmissible spongiform encephalopathies ; however, its risk to humans is still obscure. An increase in number of diseased deer in North America has raised concerns regarding the CWD risk to humans. We demonstrated that the con-firmatory procedures and the commercial diagnostic kits for bovine spongiform encephalopathy (BSE) can be adopted for the diagnosis of CWD. No CWD case was confirmed in the surveillance of 558 cervids that were examined between 2003 and 2006 in Japan.
authors.affiliation: Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masujin
authors.forename: Kimi
authors.initials: K
authors.lastname: Shimada
authors.forename: Kumiko M
authors.initials: KM
authors.lastname: Kimura
authors.forename: Morikazu
authors.initials: M
authors.lastname: Imamura
authors.forename: Ayumu
authors.initials: A
authors.lastname: Yoshida
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwamaru
authors.forename: Shirou
authors.initials: S
authors.lastname: Mohri
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D000835:Animals, Wild; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003670:Deer; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry / Q000379:methods; D007564:Japan; D018620:PrPSc Proteins / Q000032:analysis*; D011933:Reagent Kits, Diagnostic; D034081:Wasting Disease, Chronic / Q000175:diagnosis*
chemical_list: D018620:PrPSc Proteins; D011933:Reagent Kits, Diagnostic