title: Pattern of congenital malformations in consanguineous versus nonconsanguineous marriages in Kashan, Islamic Republic of Iran.
abstract: This study determined the types, patterns and prevalence of congenital malformation among the offspring of consanguineous and nonconsanguineous parents. In this prospective study of 3529 neonates delivered alive during a 1-year period, 109 had congenital malformations (3.09/1000 live births). The rate of congenital malformation was 2.0% among neonates from nonconsanguineous marriages and 7.0% from consanguineous marriages. The most common malformations were genitourinary (32.1%), musculoskeletal (22.0%) and cardiovascular (14.7%). Of the total malformed infants, 8.3% died within the neonatal period. Male infants were at greater risk for birth malformations. A history of congenital malformation was more common in siblings of consanguineous than nonconsanguineous marriages.
authors.affiliation: Department of Paediatrics, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. mosayebiir@yahoo.com
authors.forename: Z
authors.initials: Z
authors.lastname: Mosayebi
authors.forename: A H
authors.initials: AH
authors.lastname: Movahedian
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D001723:Birth Rate; D016009:Chi-Square Distribution; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D003241:Consanguinity; D016021:Epidemiologic Studies; D005260:Female; D005817:Genetic Counseling; D006771:Hospitals, Maternity; D006784:Hospitals, Teaching; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008297:Male; D008393:Marriage / Q000706:statistics & numerical data*; D015997:Neonatal Screening; D010865:Pilot Projects; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D050497:Stillbirth / Q000453:epidemiology