title: Is there a relationship between myringosclerosis and atherosclerosis?
abstract: OBJECTIVE
  Myringosclerosis and atherosclerosis are two different pathologies seen in different parts of the body. Both of these occur following a similar physiopathological process. However this has not previously been adequately discussed in the literature. Trauma to either the tympanic membrane or to the intimal layer of the arterial wall results in the formation of a sclerotic plaque. The goal of this study was to investigate the relationship between myringosclerosis and atherosclerosis.
  
  
  METHODS
  A total of 421 patients with the diagnosis of coronary artery disease were included in the study. All of the patients were evaluated for the presence of atherosclerosis by coronary angiography and for myringosclerosis by otoscopic examination.
  
  
  METHODS
  The presence of myringosclerotic plaques, plaque dimensions and bilateral involvement of tympanic membranes were compared in the groups with and without atherosclerosis.
  
  
  RESULTS
  Amongst the 316 patients (75.0%) shown to have atherosclerosis, 65 (20.5%) also had myringosclerosis. Amongst the 105 patients without atherosclerosis, 24 (22.8%) had myringosclerosis. There was no statistically significant relationship between atherosclerosis and myringosclerosis (p > 0.05). Neither plaque dimensions nor bilateral involvement of the ears showed significant difference between the two groups (p >0.05 and p >0.05, respectively).
  
  
  CONCLUSIONS
  We conclude that there is no similar genetic tendency between atherosclerosis and myringosclerosis. The significance of the plaque dimensions and the bilateral involvement of tympanic membranes have not been satisfactorily discussed in the literature and this is the first time that they are being addressed. In contrast to the reported articles, there is no relationship between atherosclerosis and myringosclerosis other than being similar pathological processes occurring as a result of endothelial-epithelial damage.
authors.affiliation: Ankara Numune Education and Research Hospital, 4th ENT Clinic, Turkey. sadin27@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Selcuk
authors.forename: F
authors.initials: F
authors.lastname: Ozlu
authors.forename: O
authors.initials: O
authors.lastname: Akdogan
authors.forename: C
authors.initials: C
authors.lastname: Ozbek
authors.forename: H
authors.initials: H
authors.lastname: Dere
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology; D008078:Cholesterol, LDL / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D015995:Prevalence; D014432:Tympanic Membrane / Q000473:pathology*
chemical_list: D008078:Cholesterol, LDL