Eat less, live longer? New insights into the role of caloric restriction in the brain.
Caloric restriction has wide-ranging health benefits and may offer protection against age-related neuronal loss and neurodegenerative disorders such as Alzheimer's disease, possibly via enhanced adult neurogenesis. While a variety of interventions such as exercise increase neurogenesis, recent work suggests that exercise and caloric restriction may work to enhance neurogenesis by different neurobiological mechanisms, suggesting a role for both diet and exercise in disease prevention.
Levenson
Cathy W
CW
Florida State University, Program in Neuroscience, Department of Nutrition, Food and Exercise Sciences, 237 Biomedical Research Facility, Tallahassee, FL 32306-4340, USA. levenson@neuro.fsu.edu
Rich
Nicholas J
NJ
D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D031204:Caloric Restriction; D006801:Humans; D008136:Longevity; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000517:prevention & control*; D009474:Neurons / Q000378:metabolism; D051381:Rats