title: Neuroprotection and repair.
abstract: Neuroprotection can be applied to treatments that have a primary role in protecting nerves and axons from damage. Alternatively it can refer to treatments which act up-stream on the primary pathology and which have a secondary neuroprotective effect. Although there are many potential neuroprotective agents, clinical evidence to prove their hypothetical action is lacking. Studying natural brain repair processes is important in understanding how repair and recovery a) is limited in disease and can b) contribute to the development of treatments to enhance this process. Different mechanisms underlie repair and recovery and they vary in the time taken to produce improvement and the degree of translation into a clinical effect. Additionally individuals may vary in their ability to repair and this may contribute to the heterogeneity of diseases such as MS.
authors.affiliation: John Radcliffe Hospital Department of Clinical Neurology, Oxford OX3 9DU, UK. jacqueline.palace@clinical-neurology.oxford.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Palace
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D019782:Riluzole / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D018696:Neuroprotective Agents; D019782:Riluzole