Dendritic cells break bonds to tolerize.
Typically, dendritic cells (DCs) induce peripheral tolerance under steady state but immunity during inflammation or infection. In this issue of Immunity, Jiang et al. (2007) identify disruption of E-cadherin interactions as a unique maturation pathway by which DCs are capable of mediating tolerance.
van den Broek
Maries
M
Institute of Experimental Immunology, CH 8091 Zurich, Switzerland. maries@van-den.broek.ch
D000818:Animals; D015820:Cadherins / Q000276:immunology / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D017634:Self Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D015820:Cadherins