title: Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells.
abstract: A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC(50)=1.85 microM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound.
authors.affiliation: Sección de Síntesis, Departamento de Química Orgánica y Farmacéutica, University of Navarra, Irunlarrea, 1, E-31008 Pamplona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Plano
authors.forename: Carmen
authors.initials: C
authors.lastname: Sanmartín
authors.forename: Esther
authors.initials: E
authors.lastname: Moreno
authors.forename: Celia
authors.initials: C
authors.lastname: Prior
authors.forename: Alfonso
authors.initials: A
authors.lastname: Calvo
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Palop
mesh_terms: D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007094:Imides / Q000737:chemistry; D008297:Male; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013329:Structure-Activity Relationship
chemical_list: D002219:Carbamates; D007094:Imides; D016566:Organoselenium Compounds