title: Improved model-based magnetic resonance spectroscopic imaging.
abstract: Model-based techniques have the potential to reduce the artifacts and improve resolution in magnetic resonance spectroscopic imaging, without sacrificing the signal-to-noise ratio. However, the current approaches have a few drawbacks that limit their performance in practical applications. Specifically, the classical schemes use less flexible image models that lead to model misfit, thus resulting in artifacts. Moreover, the performance of the current approaches is negatively affected by the magnetic field inhomogeneity and spatial mismatch between the anatomical references and spectroscopic imaging data. In this paper, we propose efficient solutions to overcome these problems. We introduce a more flexible image model that represents the signal as a linear combination of compartmental and local basis functions. The former set represents the signal variations within the compartments, while the latter captures the local perturbations resulting from lesions or segmentation errors. Since the combined set is redundant, we obtain the reconstructions using sparsity penalized optimization. To compensate for the artifacts resulting from field inhomogeneity, we estimate the field map using alternate scans and use it in the reconstruction. We model the spatial mismatch as an affine transformation, whose parameters are estimated from the spectroscopy data.
authors.affiliation: Biomedical Engineering Department, University of Rochester, Rochester, NY 14622, USA.
authors.forename: Mathews
authors.initials: M
authors.lastname: Jacob
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhu
authors.forename: Andreas
authors.initials: A
authors.lastname: Ebel
authors.forename: Norbert
authors.initials: N
authors.lastname: Schuff
authors.forename: Zhi-Pei
authors.initials: ZP
authors.lastname: Liang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D050356:Lipid Metabolism / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution