Genomics and proteomics methodologies for vulnerable populations research.
This chapter describes common genomic and proteomic methods and their application to the study of vulnerable population groups. The International HapMap project is discussed in relation to unique Haplotype single nucleotide polymorphisms (htSNPs) in population groups. In addition, studies, which have used these methods to investigate aging, ethnic, and racial specific conditions, as well as psychiatric diseases, are reviewed. Advantages and limitations of various genomic and proteomic approaches are discussed in relation to population admixture and sample selection.
Kasper
Christine E
CE
Uniformed Services University of the Health Sciences, Graduate School of Nursing, Bethesda, Maryland, USA.
D000375:Aging / Q000208:ethnology / Q000235:genetics; D001249:Asthma / Q000208:ethnology / Q000235:genetics; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics; D002874:Chromosome Mapping; D030541:Databases, Genetic; D004059:Diffusion of Innovation; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005828:Genetics, Population / Q000458:organization & administration; D023281:Genomics / Q000458:organization & administration*; D006239:Haplotypes / Q000235:genetics; D006291:Health Policy; D006801:Humans; D001523:Mental Disorders / Q000208:ethnology / Q000235:genetics; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics; D015399:Nursing Research / Q000458:organization & administration*; D009765:Obesity / Q000208:ethnology / Q000235:genetics; D010597:Pharmacogenetics / Q000458:organization & administration; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040901:Proteomics / Q000458:organization & administration*; D012107:Research Design; D035862:Vulnerable Populations / Q000208:ethnology / Q000706:statistics & numerical data