alpha4beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: methods of scan analysis.
Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.
Terrière
Emma
E
Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Sharman
Mike
M
Donaghey
Claire
C
Herrmann
Lucie
L
Lonie
Jane
J
Strachan
Marion
M
Dougall
Nadine
N
Best
Jonathan
J
Ebmeier
Klaus P
KP
Pimlott
Sally
S
Patterson
Jim
J
Wyper
David
D
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000523:psychology; D001384:Azetidines / Q000138:chemical synthesis; D001921:Brain / Q000000981:diagnostic imaging; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D000077265:Donepezil; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007189:Indans / Q000627:therapeutic use; D008297:Male; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use; D015588:Observer Variation; D010865:Pilot Projects; D010880:Piperidines / Q000627:therapeutic use; D011725:Pyridines / Q000138:chemical synthesis; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D011978:Receptors, Nicotinic / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
C426745:5-iodo-3-(2-azetidinylmethoxy)pyridine; D001384:Azetidines; D002800:Cholinesterase Inhibitors; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; D000077265:Donepezil