Microneedle array for measuring wound generated electric fields.
A microneedle array has been fabricated and applied to the measurement of transdermal skin potentials in human subjects. Potential changes were recorded in the vicinity of superficial wounds, confirming the generation of a lateral electric field in human skin. The measured electric field decays with distance from the wound edge, and is directed towards the wound. The measurement of endogenous fields in skin is a prelude to the study of the therapeutic efficacy of applied electric fields to chronic non-healing wounds.
Mukerjee
E V
EV
Center for Micro & Nano Technol., Lawrence Livermore Nat. Lab., CA 94551, USA. mukerjee2@llnl.gov
Isseroff
R R
RR
Nuccitelli
R
R
Collins
S D
SD
Smith
R L
RL
D001672:Biocompatible Materials; D004560:Electricity; D004566:Electrodes; D004582:Electronics, Medical; D004867:Equipment Design; D005898:Glass; D006801:Humans; D008904:Miniaturization; D012825:Silicon; D012867:Skin / Q000473:pathology*; D012879:Skin Physiological Phenomena; D014945:Wound Healing
D001672:Biocompatible Materials; D012825:Silicon