title: Anti-HIV-1 activity of poly(mandelic acid) derivatives.
abstract: Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMDA.
authors.affiliation: Department of Polymer Science, 118 College Drive #10076, The University of Southern Mississippi, Hattiesburg, MS 39406-10076, USA.
authors.forename: Marty
authors.initials: M
authors.lastname: Ward
authors.forename: Bing
authors.initials: B
authors.lastname: Yu
authors.forename: Victor
authors.initials: V
authors.lastname: Wyatt
authors.forename: Jelani
authors.initials: J
authors.lastname: Griffith
authors.forename: Tara
authors.initials: T
authors.lastname: Craft
authors.forename: A Robert
authors.initials: AR
authors.lastname: Neurath
authors.forename: Nathan
authors.initials: N
authors.lastname: Strick
authors.forename: Yun-Yao
authors.initials: YY
authors.lastname: Li
authors.forename: David L
authors.initials: DL
authors.lastname: Wertz
authors.forename: John A
authors.initials: JA
authors.lastname: Pojman
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Lowe
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D008333:Mandelic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011485:Protein Binding; D012995:Solubility; D013057:Spectrum Analysis; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D008333:Mandelic Acids; D014867:Water