Molecular characteristics of the Mycobacterium tuberculosis LAM-RUS family prevalent in Central Russia.
We analyzed IS6110-associated polymorphisms in the phospholipase C genes of 107 isolates of Mycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in the plcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.
Dubiley
Svetlana
S
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya, Moscow, Russia. lana@ibch.ru
Kirillov
Eugene
E
Ignatova
Anna
A
Stepanshina
Valentina
V
Shemyakin
Igor
I
D001426:Bacterial Proteins; D016000:Cluster Analysis; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology; D017385:Sequence Homology; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*; D010738:Type C Phospholipases
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D010738:Type C Phospholipases; C101028:MpcA protein, Mycobacterium tuberculosis