HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia.
Severe bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen-E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens.
Tamouza
Ryad
R
Immunology and Histocompatibility Department, CIB-HOG, AP-HP/GHU-Nord, IUh and INSERM U662, Saint-Louis Hospital, Paris, France. tamouza@histo.chu-stlouis.fr
Busson
Marc
M
Fortier
Catherine
C
Diagne
Ibrahima
I
Diallo
Dapa
D
Sloma
Ivan
I
Contouris
Hector
H
Krishnamoorthy
Rajagopal
R
Labie
Dominique
D
Girot
Robert
R
Charron
Dominique
D
D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology*; D001424:Bacterial Infections / Q000453:epidemiology / Q000235:genetics*; D044383:Black People; D015897:Comorbidity; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D006720:Homozygote; D006801:Humans; D008297:Male; D008302:Mali / Q000453:epidemiology; D010297:Paris / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D000097625:HLA-E Antigens
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens