[Prevalence of metabolic syndrome using NCEP-ATPIII and IDF definitions in Brazilian individuals].
OBJECTIVE
To analyze the biochemical profile and to characterize metabolic syndrome (MS) in patients with cardiologic medical assistance using NCEP-ATPIII and IDF definitions.


METHODS
Two hundred patients and 140 controls were studied, considering total cholesterol (TC), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc), VLDL-cholesterol (VLDLc), triglycerides (TG), fasting glycemia, abdominal waist and hypertension. Significance level was defined as P<0.05.


RESULTS
Patients showed increased glycemia levels (103+/-31.4 mg/dL) and reduced HDLc levels (48+/-13.4 mg/dL) when compared to controls (88+/-29.7 mg/dL, P<0.0001 and 53+/-15.9 mg/dL, P=0.0075; respectively). Male controls 31-50 years old showed increased TC levels (215+/-40.4 mg/dL), LDL-cholesterol (134+/-34 mg/dL), VLDL-cholesterol (30+/-11.8 mg/dL) and TG (150+/-59.4 mg/dL) when compared to women (185+/-38.2 mg/dL, P=0.0137; 111+/-35.8 mg/dL; P=0.0324; 19+/-9.7 mg/dL; P=0.0009; 93+/-49 mg/dL, P=0.0010; respectively). Women over 50 years of age showed increased TC concentrations (216+/-35.9 mg/dL), HDL-cholesterol (54+/-12.8 mg/dL) and LDL-cholesterol (138+/-30.8 mg/dL) when compared to men (190+/-44.7 mg/dL, P=0.0103; 47+/-14.5 mg/dL, P=0.0229; 119+/-33.3 mg/dL; P=0.0176; respectively). NCEP-ATPIII and IDF definitions had characterized MS in 35.5% and 46% of patients, respectively, bolding glycemia, TG and hypertension.


CONCLUSIONS
Elevated glycemia levels and reduced HDLc levels were detected in patients. Altered lipid profile observed in men 31-50 years old signals higher risk for cardiovascular diseases in young adults, while a similar profile in aged women can reflect hormonal physiological changes. Both definitions for MS diagnosis discriminate patients from controls, especially IDF, sometimes with lower capacity to determine high risk for cardiovascular complications. The high prevalence of MS in patients, even with cardiologic medical assistance, suggests predisposition for cardiovascular manifestations in Brazilian individuals.
Nakazone
Marcelo Arruda
MA
Instituto Domingo Braile de Cardiologia, Faculdade de Medicina de São José do Rio Preto, SP, Brasil. naka_med@yahoo.com
Pinheiro
Anielli
A
Braile
Maria Christiane Valéria Braga
MC
Pinhel
Marcela Augusta de Souza
MA
de Sousa
Gisele Firmino
GF
Pinheiro
Sidney
S
Brandão
Antônio Carlos
AC
Toledo
Juan Carlos Yugar
JC
Braile
Domingo Marcolino
DM
Souza
Dorotéia Rossi Silva
DR
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol