title: Long-term observation for osseointegriation of calcium 'phosphate sol-gel coating on Ti-6Al-4V implants.
abstract: OBJECTIVE
  To observe the long-term impact of calcium phosphate (CaP) sol-gel coating on bone growth around porous-surfaced implant.
  
  
  METHODS
  The porous-surfaced Ti-6Al-4V implants were prepared with the addition of a thin film of CaP sol-gel coating, and implanted into the tibiae of 8 rabbits, each with two implants. Implanted sites were allowed to heal for 2, 8, 12, and 24 weeks, after which specimens were obtained for scanning electron microscope analysis using the freeze-fracture technique.
  
  
  RESULTS
  The sol-gel coated implants recovered by freeze-fracture technique showed extensive bone growth from the endosteum along the implant surface. The bone was in direct contact with the CaP layer. The cement line-like layer was clearly demonstrated to be an intervening electron dense afibrillar layer between the CaP coat and the overlying newly deposited bone. The stability and osseointegration of the porous-surfaced implants seemed not to be affected by the osteoclastic resorption of CaP layer occurred during 24 weeks of healing.
  
  
  CONCLUSIONS
  Based on the findings in the long-term observation, the addition of a thin layer of CaP promotes an extensive osseointegrated interface between the porous-surfaced Ti-6Al-4V implants and the newly deposited bone.
authors.affiliation: Stomatology Center, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022. yangc715@126.com
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Yuan-ying
authors.initials: YY
authors.lastname: Li
authors.forename: Li-e
authors.initials: LE
authors.lastname: Meng
authors.forename: Jing-xin
authors.initials: JX
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000497:Alloys; D000818:Animals; D002130:Calcium Phosphates / Q000378:metabolism*; D005614:Freeze Fracturing; D005782:Gels; D008297:Male; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D005782:Gels; C031462:titanium alloy (TiAl6V4); C020243:calcium phosphate; D014025:Titanium