title: CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.
abstract: CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry and histopathology findings and microarray and proteomics data. CEBS contains data derived from studies of chemicals and of genetic alterations, and is compatible with clinical and environmental studies. CEBS is designed to permit the user to query the data using the study conditions, the subject responses and then, having identified an appropriate set of subjects, to move to the microarray module of CEBS to carry out gene signature and pathway analysis. Scope of CEBS: CEBS currently holds 22 studies of rats, four studies of mice and one study of Caenorhabditis elegans. CEBS can also accommodate data from studies of human subjects. Toxicogenomics studies currently in CEBS comprise over 4000 microarray hybridizations, and 75 2D gel images annotated with protein identification performed by MALDI and MS/MS. CEBS contains raw microarray data collected in accordance with MIAME guidelines and provides tools for data selection, pre-processing and analysis resulting in annotated lists of genes of interest. Additionally, clinical chemistry and histopathology findings from over 1500 animals are included in CEBS. CEBS/BID: The BID (Biomedical Investigation Database) is another component of the CEBS system. BID is a relational database used to load and curate study data prior to export to CEBS, in addition to capturing and displaying novel data types such as PCR data, or additional fields of interest, including those defined by the HESI Toxicogenomics Committee (in preparation). BID has been shared with Health Canada and the US Environmental Protection Agency. CEBS is available at http://cebs.niehs.nih.gov. BID can be accessed via the user interface from https://dir-apps.niehs.nih.gov/arc/. Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/.
authors.affiliation: NIEHS, National Center for Toxicogenomics, PO Box 12233, Research Triangle Park, NC 27709, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Waters
authors.forename: Stanley
authors.initials: S
authors.lastname: Stasiewicz
authors.forename: B Alex
authors.initials: BA
authors.lastname: Merrick
authors.forename: Kenneth
authors.initials: K
authors.lastname: Tomer
authors.forename: Pierre
authors.initials: P
authors.lastname: Bushel
authors.forename: Richard
authors.initials: R
authors.lastname: Paules
authors.forename: Nancy
authors.initials: N
authors.lastname: Stegman
authors.forename: Gerald
authors.initials: G
authors.lastname: Nehls
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Yost
authors.forename: C Harris
authors.initials: CH
authors.lastname: Johnson
authors.forename: Scott F
authors.initials: SF
authors.lastname: Gustafson
authors.forename: Sandhya
authors.initials: S
authors.lastname: Xirasagar
authors.forename: Nianqing
authors.initials: N
authors.lastname: Xiao
authors.forename: Cheng-Cheng
authors.initials: CC
authors.lastname: Huang
authors.forename: Paul
authors.initials: P
authors.lastname: Boyer
authors.forename: Denny D
authors.initials: DD
authors.lastname: Chan
authors.forename: Qinyan
authors.initials: Q
authors.lastname: Pan
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
authors.forename: John
authors.initials: J
authors.lastname: Taylor
authors.forename: Danielle
authors.initials: D
authors.lastname: Choi
authors.forename: Asif
authors.initials: A
authors.lastname: Rashid
authors.forename: Ayazaddin
authors.initials: A
authors.lastname: Ahmed
authors.forename: Reese
authors.initials: R
authors.lastname: Howle
authors.forename: James
authors.initials: J
authors.lastname: Selkirk
authors.forename: Raymond
authors.initials: R
authors.lastname: Tennant
authors.forename: Jennifer
authors.initials: J
authors.lastname: Fostel
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics; D051381:Rats; D018511:Systems Integration; D043922:Toxicogenetics; D014584:User-Computer Interface