Echinacoside prevents the striatal extracellular levels of monoamine neurotransmitters from diminution in 6-hydroxydopamine lesion rats.
We investigated the effects of echinacoside, a phenylethanoid glycoside isolated and purified from the stems of Cistanche salsa, a Chinese herbal medicine, on the striatal extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in 6-hydroxydopamine (6-OHDA) lesion rats. Seven days after 6-OHDA was injected into the right striatum of rats, the striatal extracellular levels of DA, DOPAC and HVA fell significantly (P<0.01 vs. vehicle), as demonstrated by the method of cerebral microdialysis and high performance liquid chromatography with electrochemical detection. However, simultaneous treatment with echinacoside (7.0, 3.5mg/kg) attenuated the diminution of them (P<0.01 vs. model). The results implied that echinacoside could protect the striatal dopaminergic neurons from injury induced by 6-OHDA and may be useful in the prevention and treatment of Parkinson's disease (PD).
Chen
Hong
H
Ministry of Education, Key Laboratory of Xinjiang Phytomedicine Resources, Shihezi University, Shihezi 832002, China. chenhong57@126.com
Jing
Fu Chun
FC
Li
Chang Ling
CL
Tu
Peng Fei
PF
Zheng
Qiu Sheng
QS
Wang
Zheng Hua
ZH
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis*; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis*; D006027:Glycosides / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000032:analysis*; D008297:Male; D016627:Oxidopamine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D006027:Glycosides; D015102:3,4-Dihydroxyphenylacetic Acid; D016627:Oxidopamine; C060297:echinacoside; D004298:Dopamine; D006719:Homovanillic Acid