A case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis.
A 60-year-old woman was diagnosed with esophageal small cell carcinoma in October 2004 and received chemotherapy. However, the tumor grew gradually and multiple bone metastases occurred. Anorexia, nausea, emesis, numbness in both hands, and disturbed consciousness developed at the end of January 2006, and the patient was admitted to Fukushima Medical University Hospital. Abdominal pain, marked hypercalcemia and hyperamylasemia were noted and the patient was diagnosed with severe acute pancreatitis. Because the level of blood parathyroid hormone-related protein was elevated, we considered that esophageal small cell carcinoma caused human hypercalcemia of malignancy and that metastatic bone tumors caused local osteolytic hypercalcemia, eventually leading to severe acute pancreatitis. This is an extremely rare case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis.
Kanno
Kaori
K
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan. kaori@fmu.ac.jp
Hikichi
Takuto
T
Saito
Keietsu
K
Watanabe
Kenya
K
Takagi
Tadayuki
T
Shibukawa
Goro
G
Wakatsuki
Takeru
T
Imamura
Hidemichi
H
Takahashi
Yuta
Y
Sato
Ai
A
Sato
Masaki
M
Irisawa
Atsushi
A
Obara
Katsutoshi
K
Ohira
Hiromasa
H
D000208:Acute Disease; D018288:Carcinoma, Small Cell / Q000150:complications*; D004938:Esophageal Neoplasms / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications* / Q000209:etiology; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology*