title: Two new lanostanoids from Ganoderma resinaceum.
abstract: Two new lanostane triterpenoids, 3-epipachymic acid (3alpha-acetoxy-16alpha-hydroxy-24-methylene-5alpha-lanost-8-en-21-oic acid, 1) and 3alpha-(3-hydroxy-5-methoxy-3-methyl-1,5-dioxopentyloxy)-24-methylene-5alpha-lanost-8-en-21-oic acid (2), together with a known compound, 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid (3), were isolated from the fruiting body of Ganoderma resinaceum. The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC(50) value of 2.5 microg/ml in Hep-2 cell line.
authors.affiliation: School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes