Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study.
BACKGROUND
Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA). We investigated the association between anthropometric measures of obesity, serum adipokines, and AAA.


RESULTS
As part of a population study, we screened 12,203 men 65 to 83 years of age for AAA using ultrasound; 875 had an AAA (> or = 30 mm). Cardiovascular risk factors and waist and hip circumference were recorded. Serum adipokines were measured in 952 men, 318 of whom had an AAA. Waist circumference (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.06 to 1.22) and waist-to-hip ratio (OR, 1.22; 95% CI, 1.09 to 1.37) were independently associated with AAA after adjustment for other known risk factors. The association was stronger for AAA > or = 40 mm (waist-to-hip ratio: OR, 1.53; 95% CI, 1.26 to 1.85). Serum resistin concentration was strongly independently associated with AAA (OR, 1.53; 95% CI, 1.32 to 1.76) and aortic diameter (beta=0.19, P<0.0001). Serum adiponectin was associated with AAA > or = 30 mm (OR, 1.26; 95% CI, 1.07 to 1.50) but not AAA > or = 40 mm (OR, 1.03; 95% CI, 0.77 to 1.39). Serum leptin was not associated with AAA.


CONCLUSIONS
Measures of obesity are independently associated with AAA. Serum resistin concentrations were more strongly associated with aortic diameter than adipokines that are more intimately associated with adiposity. Further studies are required to investigate the mechanisms linking resistin and AAA.
Golledge
Jonathan
J
Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, QLD, Australia 4811. jonathan.golledge@jcu.edu.au
Clancy
Paula
P
Jamrozik
Konrad
K
Norman
Paul E
PE
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000453:epidemiology*; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D054526:Men's Health; D009765:Obesity / Q000097:blood* / Q000453:epidemiology*; D052243:Resistin / Q000097:blood; D012307:Risk Factors
D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D020738:Leptin; D052243:Resistin; D002097:C-Reactive Protein