A general approach to 3-n-butyl-5-alkylindolizidines: total synthesis of (-)-indolizidine 195B.
Indolizidine type alkaloids have been attractive synthetic targets due to their biological activity. The total synthesis of (-)-indolizidine 195B via a general route, which could potentially be used to prepare other indolizidine alkaloids such as (-)-gephyrotoxin 223AB and (-)-myrmicarin 237A, is described.
Angle
Steven R
SR
Department of Chemistry, University of California Riverside, Riverside, CA 92521-0403, USA. steven.angle@wright.edu
Kim
Musong
M
D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
D007212:Indolizines; C110223:indolizidine-195B