title: Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats.
abstract: OBJECTIVE
  To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats.
  
  
  METHODS
  20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32 masculine C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation.
  
  
  RESULTS
  Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433).
  
  
  CONCLUSIONS
  Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
authors.affiliation: Division of Neurosurgery, Department of Surgery and Anatomy, Hospital das Clinicas, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, Brazil.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Benedicto Oscar
authors.initials: BO
authors.lastname: Colli
authors.forename: Luiza da Silva
authors.initials: Lda S
authors.lastname: Lopes
mesh_terms: D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D007036:Hypothermia, Induced; D002546:Ischemic Attack, Transient / Q000628:therapy*; D013997:Time Factors