title: Exposure to hexachlorobenzene through fish and seafood consumption in Catalonia, Spain.
abstract: The concentrations of hexachlorobenzene (HCB) were analyzed by HRGC/HRMS in 42 composite samples of the 14 most consumed marine species (sardine, tuna, anchovy, mackerel, swordfish, salmon, hake, red mullet, sole, cuttlefish, squid, clam, mussel, and shrimp) in Catalonia, Spain. The daily intake of HCB associated with this consumption was also estimated for four age groups of the population of Catalonia: children, adolescents, adults and seniors, which were in turn divided according to sex. The highest HCB levels were found in salmon and mackerel: 1.68 and 0.80 ng/g of wet weight, respectively, whereas the lowest HCB levels were found in cuttlefish, mussel, and shrimp (0.02, 0.03, and 0.04 ng/g of wet weight, respectively). In general terms, these results are within the range of data reported in recent years by a number of authors. The highest and lowest HCB intake (ng/day) corresponded to female adults (13.3) and girls (4.0), respectively. For most age/sex groups, salmon and sole were the species showing the highest contribution to HCB intake. When HCB intake was calculated according to the average body weight of the individuals in each group, the highest and lowest values corresponded to boys (0.32 ng/kg/day) and female adolescents (0.14 ng/kg/day). For all groups, HCB intake from fish and seafood consumption was considerably lower than the WHO tolerable daily intake (TDI), for non-cancer effects and for neoplastic effects in humans.
authors.affiliation: GRET-CERETOX, School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Falcó
authors.forename: Juan M
authors.initials: JM
authors.lastname: Llobet
authors.forename: Ana
authors.initials: A
authors.lastname: Bocio
authors.forename: José L
authors.initials: JL
authors.lastname: Domingo
mesh_terms: D000293:Adolescent; D000818:Animals; D004034:Diet Surveys; D004781:Environmental Exposure / Q000032:analysis*; D005247:Feeding Behavior; D005260:Female; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis*; D006581:Hexachlorobenzene / Q000032:analysis*; D006801:Humans; D008297:Male; D017747:Seafood / Q000032:analysis / Q000592:standards; D013030:Spain; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D014874:Water Pollutants, Chemical; D006581:Hexachlorobenzene