title: High-normal C-reactive protein levels do not affect the vitamin A transport complex in serum of children and adolescents with type 1 diabetes.
abstract: Type 1 diabetes is associated with the presence of inflammation, which in turn affects parameters used to assess the vitamin A status. In the present study, we evaluated the influence of inflammatory status on retinol, retinol-binding protein 4 (RBP4), and transthyretin (TTR) in children and adolescents with type 1 diabetes. A total of 40 children with type 1 diabetes (median age, 14.2 y; median BMI-SDS, 0.53; median diabetes duration, 5.8 y; median HbA1c, 7.3%) and 46 healthy subjects (median age, 12.8 y; median BMI-SDS, 0.34; median HbA1c 5.4%) were recruited. Serum levels of CRP were significantly elevated (p = 0.005) and retinol concentrations were significantly lower (p = 0.02) in children and adolescents with type 1 diabetes compared with healthy subjects. Serum RBP4 and TTR showed no differences between the groups. Healthy children with CRP levels above 0.6 mg/L had significant lower levels of retinol (p = 0.03). This was not observed in children with type 1 diabetes. The results suggest that, in contrast to healthy children, minor CRP elevation does not affect vitamin A transport complex in serum of children with type 1 diabetes.
authors.affiliation: Department of Physiology and Pathophysiology, Institute of Nutritional Science, University of Potsdam, Nuthetal, 14558, Germany. katharinaespe@gmx.de
authors.forename: Katharina
authors.initials: K
authors.lastname: Espe
authors.forename: Angela
authors.initials: A
authors.lastname: Galler
authors.forename: Jens
authors.initials: J
authors.lastname: Raila
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Schweigert
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D015536:Down-Regulation; D006801:Humans; D007249:Inflammation / Q000097:blood*; D011228:Prealbumin / Q000032:analysis*; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D015854:Up-Regulation; D014801:Vitamin A / Q000097:blood*
chemical_list: D011228:Prealbumin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A; D002097:C-Reactive Protein