title: Acquired kinking of the hair caused by acitretin.
abstract: Alopecia, hypertrichosis, and hirsutism may be caused by a variety of medications. Drug-induced alterations in the texture or structure of the hair shaft, however, are much less common. We report a female patient who presented with acquired generalized kinking of the hair 6 months after the initiation of acitretin therapy for psoriasis. The hair change has persisted despite reductions in the dose of acitretin. To our knowledge, this is the first report of hair kinking induced by acitretin. It has been proposed that retinoid therapy may affect keratinization of the inner root sheath to cause this structural hair shaft change.
authors.affiliation: Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. jclarke1@psu.edu
authors.forename: Jennie T
authors.initials: JT
authors.lastname: Clarke
authors.forename: Harper
authors.initials: H
authors.lastname: Price
authors.forename: Shari
authors.initials: S
authors.lastname: Clarke
authors.forename: Rosalyn
authors.initials: R
authors.lastname: George
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Miller
mesh_terms: D017255:Acitretin / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006197:Hair / Q000002:abnormalities / Q000187:drug effects*; D006201:Hair Diseases / Q000139:chemically induced; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy; D013997:Time Factors
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin