title: Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.
abstract: BACKGROUND
  Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A and rs6318 (Cys23Ser) of HTR2C have been investigated in suicide behavior in other studies.
  
  
  METHODS
  Here, we investigated rs6313 and rs6318 and other 10 randomly chosen SNPs, of those three genes in a study of 329 psychiatric patients who had never attempted suicide and 297 patients who had attempted suicide.
  
  
  RESULTS
  No associations were found for the 12 SNPS.
  
  
  CONCLUSIONS
  Our results do not support the involvement of HTR2A, 5HTT or HTR2C in suicidal behavior in Han Chinese subjects.
authors.affiliation: Bio-X Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Shen
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.forename: Xingwang
authors.initials: X
authors.lastname: Li
authors.forename: Junwei
authors.initials: J
authors.lastname: Meng
authors.forename: Shengzhen
authors.initials: S
authors.lastname: Guo
authors.forename: Huafang
authors.initials: H
authors.lastname: Li
authors.forename: Niufan
authors.initials: N
authors.lastname: Gu
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D012701:Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D012737:Sex Factors; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D005819:Genetic Markers; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin