Syndromes related to sodium and arginine vasopressin alterations in post-operative neurosurgery.
BACKGROUND
Cerebral salt wasting syndrome (CSWS), syndrome of inappropriate antidiuretic hormone secretion (SIADH) and diabetes insipidus (DI) are frequently found in postoperative neurosurgery.


OBJECTIVE
To identify these syndromes following neurosurgery.


METHODS
The study included 30 patients who had been submitted to tumor resection and cerebral aneurysm clipping. Sodium levels in serum and urine and urine volume were measured daily up to the 5th day following surgery. Plasma arginine vasopressin (AVP) was measured on the first, third and fifth days post-surgery.


RESULTS
CSWS was found in 27/30 patients (90%), in 14 (46.7%) of whom it was associated with a reduction in the levels of plasma AVP (mix syndrome). SIADH was found in 3/30 patients (10%). There was no difference between the two groups of patients.


CONCLUSIONS
CSWS was the most common syndrome found, and in half the cases it was associated with DI. SIADH was the least frequent syndrome found.
Cardoso
Ana P D
AP
Intensive Care Unit, Department of Surgery, School of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Dragosavac
Desanka
D
Araújo
Sebastião
S
Falcão
Antonio L E
AL
Terzi
Renato G G
RG
Castro
Margaret de
Md
Marcondes
Fabiana G
FG
Melo
Taís G
TG
Oliveira
Rosmari A R A
RA
Cintra
Eliana A
EA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001127:Arginine Vasopressin / Q000097:blood*; D001932:Brain Neoplasms / Q000601:surgery*; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis / Q000209:etiology*; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D011183:Postoperative Complications / Q000175:diagnosis; D012307:Risk Factors; D012964:Sodium / Q000032:analysis*; D014882:Water-Electrolyte Balance
D001127:Arginine Vasopressin; D012964:Sodium