Susceptibility of candida isolates from denture-related stomatitis to antifungal agents in vitro.
The aim of this study was to determine the susceptibility of Candida isolates obtained from patients with Candida-associated denture stomatitis to 4 antimycotics. Antifungal susceptibility was assayed using the ATB-Fungus-2INT test. A total of 120 Candida strains were identified: C albicans (59.2%), C glabrata (20%), C tropicalis (12.5%), and C parapsilosis (8.3%). Amphotericin B, 5-fluorocytosine, fluconazole, and itraconazole were effective against 100%, 98.6%, 88.7%, and 87.3% of C albicans and 79.6%, 77.6%, 71.4%, and 79.6% of the other Candida strains, respectively. The identification of candidal strains and determination of their susceptibility to antifungals may improve the management of Candida-associated denture stomatitis.
Dorocka-Bobkowska
Barbara
B
Department of Prosthetic Dentistry, Poznan University of Medical Sciences, Poland. badb@mp.pl
Konopka
Krystyna
K
D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000382:microbiology*; D015169:Colony Count, Microbial; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D013282:Stomatitis, Denture / Q000382:microbiology*
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine