Hemodynamic effect of iopromide in pancreas-duodenum transplanted rats.
BACKGROUND
Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation, especially in acute pancreatitis.


OBJECTIVE
To evaluate the effects of the low-osmolar CM iopromide on total pancreatic and especially islet blood perfusion after whole pancreas transplantation.


METHODS
Rats receiving a pancreas-duodenum transplantation 2 days earlier, i.e., with graft pancreatitis, were injected with iopromide. Blood perfusion measurements were then made with a microsphere technique.


RESULTS
The graft blood perfusion was decreased in control rats when compared to the endogenous pancreas. Administration of iopromide increased both total pancreatic and islet blood perfusion in the grafted pancreas, but not in the endogenous gland. No effects on blood perfusion to either the native or transplanted duodenum were seen after iopromide administration.


CONCLUSIONS
Iopromide increases the blood perfusion of a whole pancreas transplant 2 days after implantation, i.e., when graft pancreatitis is present. The consequences of this CM-induced hyperperfusion for graft pancreatic function remain to be established.Key words: Intravascular contrast media; islet blood perfusion; graft pancreatitis;pancreas transplantation; pancreatic blood perfusion
Linder
G
G
Carlsson
P O
PO
Källskog
Ö
Ö
Hansell
P
P
Jansson
L
L
Riesenfeld Källskog
V
V
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004386:Duodenum / Q000637:transplantation; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010179:Pancreas / Q000098:blood supply* / Q000187:drug effects*; D016035:Pancreas Transplantation; D010195:Pancreatitis; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide