title: Auditory cortical plasticity induced by intracortical microstimulation under pharmacological blockage of inhibitory synapses.
abstract: Electrical stimulation that can reorganize our neural system has a potential for promising neurorehabilitation. We previously demonstrated that temporally controlled intracortical microstimulation (ICMS) could induce the spike time-dependant plasticity and modify tuning properties of cortical neurons as desired. A 'pairing' ICMS following tone-induced excitatory post-synaptic potentials (EPSPs) produced potentiation in response to the paired tones, while an 'anti-pairing' ICMS preceding the tone-induced EPSPs resulted in depression. However, the conventional ICMS affected both excitatory and inhibitory synapses, and thereby could not quantify net excitatory synaptic effects. In the present work, we evaluated the ICMS effects under a pharmacological blockage of inhibitory inputs. The pharmacological blockage enhanced the ICMS effects, suggesting that inhibitory inputs determine a plastic degree of the neural system. Alternatively, the conventional ICMS had an inadequate timing to control excitatory synaptic inputs, because inhibitory synapse determined the latency of total neural inputs.
authors.affiliation: Graduate Sch. of Inf. Sci. & Technol., Tokyo Univ., Meguro-ku, Tokyo, Japan. yokota@brain.imi.i.u-tokyo.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Yokota
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Funamizu
authors.forename: M
authors.initials: M
authors.lastname: Uchihara
authors.forename: J
authors.initials: J
authors.lastname: Suzurikawa
authors.forename: R
authors.initials: R
authors.lastname: Kanzaki
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000473:pathology*; D001640:Bicuculline / Q000031:analogs & derivatives* / Q000494:pharmacology; D002450:Cell Communication; D002540:Cerebral Cortex; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D009473:Neuronal Plasticity; D009474:Neurons / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism; D013569:Synapses; D009435:Synaptic Transmission; D013997:Time Factors
chemical_list: D011963:Receptors, GABA-A; C017069:bicuculline methiodide; D001640:Bicuculline