Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide iota.
The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemic Josiphos-related ligand (R,S)-PPF-P(t-Bu)2 was successfully used to introduce each of three stereocenters found in the target compound.
Lipshutz
Bruce H
BH
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. lipshutz@chem.ucsb.edu
Lee
Ching-Tien
CT
Servesko
Jeff M
JM