[The preliminary application of autologous platelet-rich gel used to treat refractory diabetic dermal ulcer].
OBJECTIVE
To assess the effectiveness and security of autologous platelet-rich gel (APG) in the treatment of refractory diabetic dermal ulcers.


METHODS
Thirteen diabetic patients with refractory skin lesions were enrolled for this study, and APG was produced by platelet (PLT)-rich plasma (PRP) with thrombin and calcium gluconate. APG treatment consisted of wound dressed with APG, followed by topical washing and cleaning. The APG was then covered with Vaseline gauze and left for 48 to 72 hours, after which the wounds were treated conventionally until the next PLT-gel treatment. The clinical endpoints of the study were the healing rate.


RESULTS
A total of 13 patients entered the pilot study. There were no drop-outs in the study. 69.2% ulcers were cured, and especially the ulcer areas were reduced significantly in the first 3 weeks; no adverse reactions were observed.


CONCLUSIONS
Topical therapy with APG may be considered as an effective adjuvant method to treating refractory diabetic dermal ulcer.
Yuan
Nan-bing
NB
Diabetic Foot Care Center, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Chun
C
Wang
Yan
Y
Yu
Ting-ting
TT
Shu
Shi-qing
SQ
Liu
Min
M
Ran
Xing-wu
XW
D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets; D002125:Calcium Gluconate / Q000008:administration & dosage / Q000627:therapeutic use; D048909:Diabetes Complications; D005260:Female; D005782:Gels / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D012883:Skin Ulcer / Q000628:therapy*; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
D005782:Gels; D013917:Thrombin; D002125:Calcium Gluconate