title: [Expression of TR4-associated protein in non-small cell lung cancer].
abstract: OBJECTIVE
  To investigate the expression and significance of TR4-associated Protein (TRA16) in human non-small cell lung cancer (NSCLC) tissues.
  
  
  METHODS
  Immunohistochemistry (IHC) and tissue array were employed to investigate the expression of TRA16 in NSCLC cases of different pathological types, benign lung lesions and normal lung tissues.
  
  
  RESULTS
  The abundant expression of TRA16 was observed in nucleus and/or cytoplasm of NSCLC cells with a positive expression rate of 88.64%, whereas normal lung tissue and benign lung tumor rarely expressed TRA16 protein. The expression of TRA16 showed no apparent difference at pathotypes and differentiation levels.
  
  
  CONCLUSIONS
  In this study we demonstrated an abnormal overexpression of TRA16 in NSCLC tissues. The unique expression pattern of TRA16 indicated its probable role in tumorigenesis and progression, supporting the development of TRA16 as a novel potential NSCLC marker.
authors.affiliation: Department of Thoracic Surgery, Peking University School of Oncology, Beijing Cancer Hospital Institute, Beijing 100036, China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Zheng
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Hong
authors.initials: H
authors.lastname: DU
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Xiong
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Lu
authors.initials: L
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Ao
authors.forename: Ji-You
authors.initials: JY
authors.lastname: Li
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Ji
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: C472782:NR2C2AP protein, human; D009687:Nuclear Proteins; D012097:Repressor Proteins