title: Chondrocyte nuclear response to osmotic loading.
abstract: Cartilage compression results in changes in the shape, volume as well as hydrostatic and osmotic pressure of chondrocytes in situ. For example, changes in the cellular osmotic environment have been shown to modulate chondrocyte biosynthesis and gene expression, however, the mechanosensing mechanisms mediating these responses are relatively unknown. Nuclear shape and size changes resulting from cell deformation have been suggested to alter cell functions, and as such we recently performed a study that reported that chondrocytes and their nuclei respond to osmotic loading with alterations in their size. In the current study, we focus on the potential role of the actin cytoskeleton in mediating the transmission of osmotic loading-induced cell size changes to the nucleus.
authors.affiliation: Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Oswald
authors.forename: Pen-hsiu G
authors.initials: PH
authors.lastname: Chao
authors.forename: J Chloe
authors.initials: JC
authors.lastname: Bulinski
authors.forename: Gerard A
authors.initials: GA
authors.lastname: Ateshian
authors.forename: Clark T
authors.initials: CT
authors.lastname: Hung
mesh_terms: D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D048430:Cell Shape; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D015638:Cytochalasin D / Q000494:pharmacology; D006874:Hydrostatic Pressure; D008954:Models, Biological; D009997:Osmotic Pressure; D016474:Weight-Bearing
chemical_list: D015638:Cytochalasin D