Synthesis and antidepressant evaluation of three para-benzoquinone mono-oximes and their oxy derivatives.
A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5-methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.
de Sousa
Damião Pergentino
DP
Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Brazil. damiao50@yahoo.com.br
Schefer
Renata Rabelo
RR
Brocksom
Ursula
U
Brocksom
Timothy John
TJ
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D016227:Benzoquinones / Q000737:chemistry*; D008297:Male; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013550:Swimming; D014867:Water
D000928:Antidepressive Agents; D016227:Benzoquinones; D010091:Oximes; D014867:Water; C004532:quinone