Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells.
A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC(50)=1.85 microM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound.
Plano
Daniel
D
Sección de Síntesis, Departamento de Química Orgánica y Farmacéutica, University of Navarra, Irunlarrea, 1, E-31008 Pamplona, Spain.
Sanmartín
Carmen
C
Moreno
Esther
E
Prior
Celia
C
Calvo
Alfonso
A
Palop
Juan Antonio
JA
D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007094:Imides / Q000737:chemistry; D008297:Male; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013329:Structure-Activity Relationship
D002219:Carbamates; D007094:Imides; D016566:Organoselenium Compounds