Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging.
A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After (64)Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.
Zhang
Yi
Y
Department of Radiology, The University of Virginia, 409 Lane Road, MR4 Building 1192, PO Box 801339, Charlottesville, VA 22908, USA.
Kundu
Bijoy
B
Fairchild
Karen D
KD
Locke
Landon
L
Berr
Stuart S
SS
Linden
Joel
J
Pan
Dongfeng
D
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049268:Positron-Emission Tomography / Q000379:methods*
D010455:Peptides