title: Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size.
abstract: OBJECTIVE
  We examined the serum levels of interferon-gamma-inducible protein 10 (IP-10), an inflammation-induced chemokine, in acute myocardial infarction (AMI).
  
  
  METHODS
  The subjects were 33 AMI patients, 20 stable angina pectoris patients (AP) and 20 normal subjects. In AMI patients, blood samples were collected before percutaneous coronary intervention (PCI) and on days 3, 7 and 28.
  
  
  RESULTS
  Patients with AMI showed significantly higher serum IP-10 levels (137.5+/-79.8 pg/mL) than control subjects (91.2+/-40.1 pg/mL) and patients with AP (93.3+/-41.1 pg/mL). The serum IP-10 level before PCI was negatively correlated with infarct size, as indicated by cumulative release of creatine kinase (CK) and peak CK and its isoenzyme CK-MB. Stepwise multiple regression analysis revealed that the serum IP-10 level before PCI was an independent predictor of cumulative CK release.
  
  
  CONCLUSIONS
  The serum IP-10 level was increased in AMI, and a higher level of serum IP-10 before PCI may be informative regarding infarct size.
authors.affiliation: Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Koten
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirohata
authors.forename: Toru
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Usui
authors.forename: Ryoko
authors.initials: R
authors.lastname: Shinohata
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kitawaki
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Kosaku
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood*; D017023:Coronary Angiography; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D018450:Disease Progression; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology*; D016277:Ventricular Function, Left
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form