The role of bisphosphonates in the management of patients that have cancer.
Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
Fan
Timothy M
TM
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, IL 61802, USA. t-fan@uiuc.edu
D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control / Q000556:secondary / Q000662:veterinary*; D002371:Cat Diseases / Q000517:prevention & control*; D002415:Cats; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D009362:Neoplasm Metastasis
D050071:Bone Density Conservation Agents; D004164:Diphosphonates