title: Enantioselective synthesis and vanilloid activity evaluation of 1-beta-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks.
abstract: A simple strategy is outlined for preparation of the antinociceptive 1-beta-(p-methoxycinnamoyl)polygodial, isolated from Drymis winteri barks. The synthesized compound showed vanilloid activity.
authors.affiliation: Dipartimento di Chimica, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Della Monica
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.forename: Raffaella
authors.initials: R
authors.lastname: Landi
authors.forename: Irene
authors.initials: I
authors.lastname: Izzo
authors.forename: Aldo
authors.initials: A
authors.lastname: Spinella
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000302:isolation & purification; D002460:Cell Line; D032424:Drimys; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000138:chemical synthesis / Q000302:isolation & purification; D013237:Stereoisomerism; D050916:TRPV Cation Channels / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D050916:TRPV Cation Channels