Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments.
The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.
Gauthier
Nicholas Paul
NP
Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark.
Larsen
Malene Erup
ME
Wernersson
Rasmus
R
de Lichtenberg
Ulrik
U
Jensen
Lars Juhl
LJ
Brunak
Søren
S
Jensen
Thomas Skøt
TS
D017360:Arabidopsis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics*; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D018816:Genes, cdc; D006801:Humans; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis; D004718:Saccharomycetales / Q000235:genetics; D012568:Schizosaccharomyces / Q000235:genetics; D014584:User-Computer Interface