title: Prokinetic therapy reduces aspiration pneumonia in tube-fed patients with severe developmental disabilities.
abstract: To evaluate the clinical benefit of prokinetic therapy in aspiration pneumonia in patients with developmental disabilities, we conducted a retrospective study; records of 22 tube-fed patients were reviewed from December 1990 to October 1998 for a mean of 22.7 months before and 38.9 months during Cisapride therapy. Numbers of hospital admissions per patient-year before and during Cisapride administration were reduced from 2.75 to .61, with a relative risk reduction of 4.5. Days of hospitalization were reduced from 32.3 to 6.4. There were no adverse events noted from the therapy. Appropriately monitored prokinetic therapy may prove to be beneficial in preventing aspiration pneumonia in selected patients with developmental disabilities.
authors.affiliation: University of Mississippi Medical Center, Digestive Diseases, Jackson 39216, USA.
authors.forename: Namita
authors.initials: N
authors.lastname: Pareek
authors.forename: John
authors.initials: J
authors.lastname: Williams
authors.forename: Deborah
authors.initials: D
authors.lastname: Hanna
authors.forename: William D
authors.initials: WD
authors.lastname: Johnson
authors.forename: Anil
authors.initials: A
authors.lastname: Minocha
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Abell
mesh_terms: D002675:Child, Preschool; D020117:Cisapride / Q000627:therapeutic use*; D002658:Developmental Disabilities / Q000453:epidemiology*; D004750:Enteral Nutrition / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011015:Pneumonia, Aspiration / Q000453:epidemiology* / Q000517:prevention & control*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D017366:Serotonin Receptor Agonists; D020117:Cisapride