title: Eating disorder and metabolism in narcoleptic patients.
abstract: OBJECTIVE
  To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.
  
  
  METHODS
  Case controlled pilot study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.
  
  
  METHODS
  Energy balance was evaluated by measuring BMI, rest energy expenditure with calorimetry, daily food and water intake, and plasma hormone levels. Eating behavior was evaluated using psychometric tests (EAT-40, EDI2, CIDI-2, MADRS).
  
  
  RESULTS
  Patients with narcolepsy (whether typical or not) tended to be overweight and to have a lower basal metabolism than controls. Only patients with typical narcolepsy tended to eat less than controls. Narcoleptic patients who were overweight ate half as much as others, indicating caloric restriction. Plasma glucose, cortisol, thyroid, and sex hormones levels did not differ between groups, while prolactin levels were twice as high in patients with narcolepsy as in controls. Narcoleptic patients had higher EAT-40 scores and more frequent features of bulimia nervosa (independent of depressive mood) than controls, suggesting a mild eating disorder, classified as "Eating Disorder Not Other Specified."
  
  
  CONCLUSIONS
  Both lower basal metabolism and subtle changes in eating behavior (rather than in calorie intake) could explain the positive energy balance leading to overweight in narcolepsy. Eating behavior changes may be a strategy to control weight or to avoid daytime sleepiness.
authors.affiliation: Fédération des maladies du système nerveux, Programme AVENIR, Inserm U546, France.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Chabas
authors.forename: Christine
authors.initials: C
authors.lastname: Foulon
authors.forename: Jesus
authors.initials: J
authors.lastname: Gonzalez
authors.forename: Mireille
authors.initials: M
authors.lastname: Nasr
authors.forename: Olivier
authors.initials: O
authors.lastname: Lyon-Caen
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Willer
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Derenne
authors.forename: Isabelle
authors.initials: I
authors.lastname: Arnulf
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002151:Calorimetry; D016022:Case-Control Studies; D002149:Energy Intake; D004734:Energy Metabolism; D001068:Feeding and Eating Disorders / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005518:Food Preferences; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009290:Narcolepsy / Q000150:complications / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D010865:Pilot Projects; D011594:Psychometrics; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones; D006854:Hydrocortisone