title: Current data with inulin-type fructans and calcium, targeting bone health in adults.
abstract: In humans, there is increasing evidence that the colon can absorb nutritionally significant amounts of calcium, and this process may be susceptible to dietary manipulation by fermentable substrates, especially inulin-type fructans. Inulin-type fructans can modulate calcium absorption because they are resistant to hydrolysis by mammalian enzymes and are fermented in the large intestine to produce short-chain fatty acids, which in turn reduce luminal pH and modify calcium speciation, and hence solubility, or exert a direct effect on the mucosal transport pathway. Quite a few intervention studies showed an improvement of calcium absorption in adolescents or young adults by inulin-type fructans. In the same way, a positive effect has been reported in older women.
authors.affiliation: Unité de Nutrition Humaine (UMR1019), Equipe Alimentation Squelette et Métabolismes INRA Theix, Saint-Genès Champanelle, France. coxam@clermont.inra.fr
authors.forename: Véronique
authors.initials: V
authors.lastname: Coxam
mesh_terms: D000328:Adult; D000368:Aged; D001682:Biological Availability; D002113:Calcification, Physiologic / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000378:metabolism / Q000493:pharmacokinetics / Q000502:physiology; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005630:Fructans / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007444:Inulin / Q000494:pharmacology / Q000502:physiology*; D008875:Middle Aged
chemical_list: D002136:Calcium, Dietary; D005630:Fructans; D007444:Inulin; D002118:Calcium