Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization.
Although the acute clinical effects of ciguatera poisoning, due to ingestion of ciguatoxin, are mediated by activation of transient Na+ channels, the mechanisms underlying ciguatera sensitization remain undefined. Axonal excitability studies were performed by stimulating the median motor and sensory nerves in two patients with ciguatera sensitization. Excitability parameters were all within normal limits, thereby arguing against dysfunction of axonal membrane ion channels in large-diameter fibers in ciguatera sensitization.
Vucic
Steve
S
Prince of Wales Medical Research Institute and Prince of Wales Clinical School, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia.
Kiernan
Matthew C
MC
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D036841:Ciguatera Poisoning / Q000473:pathology* / Q000503:physiopathology*; D016001:Confidence Intervals; D004576:Electromyography; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008875:Middle Aged; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology* / Q000528:radiation effects
D007473:Ion Channels