Design of nanoparticle-based dry powder pulmonary vaccines.
The development of needle-less vaccination for pulmonary delivery may require dry forms of vaccines whose powder properties allow for a low cost, heat and freeze tolerance, efficient aerosolization, and the ability to target cells of the immune system. For each of these reasons, nanoparticles can play a critical role in the formulation, development and delivery of needle-less vaccination. This review aims to communicate present biomaterial design issues surrounding the incorporation of nanoparticles into pulmonary vaccines.
Pulliam
Brian
B
Graduate Program in Biophysics, Harvard University Faculty of Arts and Sciences, 40 Oxford Street, ESL 406, Cambridge, MA 02138, USA.
Sung
Jean C
JC
Edwards
David A
DA
D000280:Administration, Inhalation; D000336:Aerosols / Q000737:chemistry; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011208:Powders; D014612:Vaccines / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology
D000336:Aerosols; D011208:Powders; D014612:Vaccines; D019444:Vaccines, DNA