Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins.
The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.
Viola
Antonella
A
Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy. University of Milan, Faculty of Medicine, Italy. antonella.viola@humanitas.it
Gupta
Neetu
N
D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D021962:Membrane Microdomains / Q000276:immunology* / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000276:immunology
D000199:Actins; D008840:Microfilament Proteins