title: Invasive fungal infections among inpatients with acquired immune deficiency syndrome at a Chinese university hospital.
abstract: Invasive fungal infections (IFIs) have become a major cause of morbidity and mortality among people with acquired immune deficiency syndrome (AIDS), however, little is known about the clinical features and prognosis of IFI in AIDS in China. This study aimed to characterise the clinical features and prognosis of IFI in AIDS patients in China. We retrospectively reviewed the records of all HIV-infected patients at a Chinese university hospital between December 2004 and May 2006. We identified 35 patients with IFI. IFIs included thrush, oesophageal candidiasis, fungal pneumonia, cryptococcosis, penicilliosis and fungaemia, 44.4% of IFIs occurred in the digestive tract, 71.8% of IFIs occurred in patients with CD4(+)T-lymphocyte counts <100 cells mm(-3). Candida albicans accounted for 57.4% of fungal pathogens isolated. All the patients received both antiretroviral and antifungal therapy; 27 patients were cured and eight died. IFI is one of the most common opportunistic infections in AIDS patients in China. IFIs mainly occur in patients with low CD4(+)T-lymphocyte counts. The majority of IFIs occur in the digestive tract. The most common pathogen causing IFI is C. albicans. The mortality rate remains high although antiretroviral therapy and many newer antifungals are available in China.
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors.forename: Yin Zhong
authors.initials: YZ
authors.lastname: Shen
authors.forename: Tang Kai
authors.initials: TK
authors.lastname: Qi
authors.forename: Jian Xin
authors.initials: JX
authors.lastname: Ma
authors.forename: Xue Yan
authors.initials: XY
authors.lastname: Jiang
authors.forename: Jiang Rong
authors.initials: JR
authors.lastname: Wang
authors.forename: Qing Nian
authors.initials: QN
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.forename: Xi Nian
authors.initials: XN
authors.lastname: Liu
authors.forename: Hong Qing
authors.initials: HQ
authors.lastname: Sun
authors.forename: Hong Zhou
authors.initials: HZ
authors.lastname: Lu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D002176:Candida albicans / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D002681:China; D003453:Cryptococcosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents