title: Use of dye as tracer of drug release from medicated chewing gums.
abstract: The evaluation of the potential use of a dye as indicator of in vivo drug release from a medicated chewing gum is described. The device is a three-layer tablet obtained by direct compression consisting of a gum core and two external protective soluble layers to prevent gum adhesion to the punches of the tableting machine. The active ingredient and a colour are contained in the gum core. To evaluate the drug and the dye release from the formulations, a chew-out study was performed by a panel of volunteers. The results obtained suggest that the use of a dye could be useful to indicate the chewing time necessary to complete drug delivery from medicated chewing gums.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy. labtec2@unipv.it
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ochoa
authors.forename: Lauretta
authors.initials: L
authors.lastname: Maggi
authors.forename: Stefania
authors.initials: S
authors.lastname: Conti
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Conte
authors.forename: Guy
authors.initials: G
authors.lastname: Vergnault
authors.forename: Pascal
authors.initials: P
authors.lastname: Grenier
mesh_terms: D002638:Chewing Gum; D004396:Coloring Agents; D004304:Dosage Forms; D008787:Metoclopramide / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013607:Tablets
chemical_list: D002638:Chewing Gum; D004396:Coloring Agents; D004304:Dosage Forms; D013607:Tablets; D008787:Metoclopramide