title: Image based modeling of defibrillation in children.
abstract: Volume imaging, defibrillation electrode models, and finite element modeling are employed in patient-specific procedural modeling in pediatric patients with cardiac arrhythmias. Due to variable size and anatomy, these patients may not be well-served by devices designed for adult defibrillation. A pipeline for rapid creation of image based models that can be interactively interrogated to determine optimal defibrillation scenarios and preliminary proof-of-concept work are presented. This approach has potential clinical applications for therapy planning and broad applications for finite element modeling in anatomical models. Clinical studies investigating the effects of body size, habitus, and anatomical variation on myocardial voltage gradients are planned.
authors.affiliation: Dept. of Cardiology, Children's Hosp. Boston, and Laboratory of Mathematics in Imaging, Harvard Medical School, MA 02115, USA. matthew.jolley@tch.harvard.edu
authors.forename: Matthew
authors.initials: M
authors.lastname: Jolley
authors.forename: John
authors.initials: J
authors.lastname: Triedman
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Westin
authors.forename: David M
authors.initials: DM
authors.lastname: Weinstein
authors.forename: Robert
authors.initials: R
authors.lastname: MacLeod
authors.forename: Dana
authors.initials: D
authors.lastname: Brooks
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004554:Electric Countershock / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome