A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells.
From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR.
Kawamura
Akira
A
Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
Iacovidou
Maria
M
Takaoka
Anna
A
Soll
Clifford E
CE
Blumenstein
Michael
M
D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D029001:Herbal Medicine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D053279:Polyynes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013927:Thrombosis / Q000378:metabolism*
D010936:Plant Extracts; D053279:Polyynes