title: [Coma with bilateral mydriasis after use of transdermal scopolamine in ICU].
abstract: We report the case of an ICU patient with previous medical history of head trauma with hydrocephalus requiring ventricular derivation, presenting a coma (Glasgow Coma Score=8) with bilateral mydriasis after the use of transdermal scopolamine (1 mg) for profuse bronchial secretions. Neurological explorations (CT-scan and electroencephalogram) confirmed the absence of organic cause to the neurological deterioration. Neurological status rapidly and completely improved after removal of transdermal scopolamine suggesting a central anticholinergic syndrome.
authors.affiliation: Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, APHP, faculté de médecine, université Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
authors.forename: X
authors.initials: X
authors.lastname: Repéssé
authors.forename: T
authors.initials: T
authors.lastname: Geeraerts
authors.forename: J
authors.initials: J
authors.lastname: Pottecher
authors.forename: B
authors.initials: B
authors.lastname: Vigué
authors.forename: D
authors.initials: D
authors.lastname: Benhamou
authors.forename: J
authors.initials: J
authors.lastname: Duranteau
mesh_terms: D000279:Administration, Cutaneous; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced*; D012151:Resuscitation; D012601:Scopolamine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018680:Cholinergic Antagonists; D012601:Scopolamine