Applications of hydrogels for neural cell engineering.
Hydrogels, three-dimensional networks of hydrophilic polymers, are currently being investigated for use in a variety of tissue-engineering applications. Hydrogel materials generally exhibit a number of properties including permeability to oxygen and nutrients, which make these materials attractive for use in biological applications. However, in order for such polymers to be successfully integrated into biological systems, these constructs must be engineered so as to mimic native biological interfaces. In this paper we discuss the use of acrylate-based polymers and their derivatives, for use in biomedical applications, including drug delivery, tissue engineering, cell encapsulation, and as templates for directed cell growth, attachment and proliferation.
Hynd
Matthew R
MR
Laboratory of Nervous System Disorders, Wadsworth Center, P.O. Box 509, Empire State Plaza, Albany, NY 12201-0509, USA. mhynd@wadsworth.org
Turner
James N
JN
Shain
William
W
D020106:Acrylamide / Q000378:metabolism; D000818:Animals; D001709:Biotechnology / Q000379:methods; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels; D008689:Methacrylates / Q000737:chemistry; D008751:Methylene Blue / Q000737:chemistry; D009474:Neurons / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010539:Permeability; D011108:Polymers / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D014466:Ultraviolet Rays
D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; D020106:Acrylamide; C005044:hydroxyethyl methacrylate; D010100:Oxygen; D008751:Methylene Blue