Co-administration of Dalbergia odorifera increased bioavailability of Salvia miltiorrhizae in rabbits.
This study was to investigate the effect of Dalbergia odorifera (DO) on the pharmacokinetics of Danshensu in Salvia miltiorrhiza (SM) in healthy rabbits and rabbits with qi-stagnancy and blood stasis. Thirty two healthy rabbits were involved in the whole experiment. Qi-stagnancy and blood stasis rabbits were obtained by treating the limbs of 16 adnephrin rabbits in an ice-bath for 6.0 min. The rest of rabbits were equally divided into 2 healthy groups. One healthy group and 8 qi-stagnancy and blood stasis rabbits were orally administrated with SM (5.0 g/kg), and the other 8 healthy rabbits and 8 qi-stagnancy and blood stasis rabbits with SM (5.0 g/kg) coupled with DO (2.5 g/kg). The plasma (Danshensu) concentration-time curve was measured by high performance liquid chromatography (HPLC)-electrospray ionization (ESI)-trap mass (MS-MS). Danshensu in plasma was confirmed to be two-compartment open model with a first order absorption phase in all groups. Moreover, the area under curve (0-infinity) of Danshensu was significantly increased both in healthy group and in qi-stagnancy and blood stasis group after administration of SM coupled with DO. This result was in accordance with the "Jun-Shi pairing herbs theory" of traditional Chinese medicine (TCM).
Zheng
Xiaohui
X
Institute of Analytical Science/Shaanxi Provincial Key Laboratory of Elecetroanalytical Chemistry, Northwest University, Northwest University, Xi'an 710069, China.
Zhao
Xinfeng
X
Wang
Shixiang
S
Luo
Kai
K
Wei
Yinmao
Y
Zheng
Jianbin
J
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D035782:Dalbergia / Q000737:chemistry*; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits; D027544:Salvia / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
D010936:Plant Extracts