title: Gamma oscillations distinguish true from false memories.
abstract: To test whether distinct patterns of electrophysiological activity prior to a response can distinguish true from false memories, we analyzed intracranial electroencephalographic recordings while 52 patients undergoing treatment for epilepsy performed a verbal free-recall task. These analyses revealed that the same pattern of gamma-band (28-100 Hz) oscillatory activity that predicts successful memory formation at item encoding--increased gamma power in the hippocampus, prefrontal cortex, and left temporal lobe--reemerges at retrieval to distinguish correct from incorrect responses. The timing of these oscillatory effects suggests that self-cued memory retrieval begins in the hippocampus and then spreads to the cortex. Thus, retrieval of true, as compared with false, memories induces a distinct pattern of gamma oscillations, possibly reflecting recollection of contextual information associated with past experience.
authors.affiliation: University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Per B
authors.initials: PB
authors.lastname: Sederberg
authors.forename: Andreas
authors.initials: A
authors.lastname: Schulze-Bonhage
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Madsen
authors.forename: Edward B
authors.initials: EB
authors.lastname: Bromfield
authors.forename: Brian
authors.initials: B
authors.lastname: Litt
authors.forename: Armin
authors.initials: A
authors.lastname: Brandt
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kahana
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D012094:Repression, Psychology; D014825:Vocabulary