Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23).
We report a unique case of childhood acute leukemia. The leukemia blasts had lymphoblastoid appearance and expressed CD33, CD13, CD34, CD4, CD7, and CD56. The morphology and immunophenotype were most consistent with myeloid/natural killer precursor acute leukemia. The blasts had a complex karyotype, including two chromosomal aberrations, der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23), not previously described in childhood acute leukemia. The patient achieved morphological remission following myeloid-based leukemia therapy.
Abdelhaleem
Mohamed
M
Division of Haematopathology, Department of Paediatric Laboratory Medicine, Room 3691, Atrium, Hospital for Sick Children, Toronto, Ontario, Canada. mohamed.abdelhaleem@sickkids.ca
Shago
Mary
M
Sayeh
Ebrahim
E
Abla
Oussama
O
D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007621:Karyotyping; D007694:Killer Cells, Natural / Q000276:immunology; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D014178:Translocation, Genetic
D015703:Antigens, CD