The influence of a beta-electron withdrawing substituent in aldol reactions of methylketone boron enolates.
We wish to describe here that good levels of substrate-based, 1,5-syn-stereocontrol could be achieved in the boron-mediated aldol reactions of beta-trichloromethyl methylketones with achiral aldehydes, independent of the nature of the beta-alkoxy protecting group.
Dias
Luiz C
LC
Instituto de Química, Universidade Estadual de Campinas, Campinas, SP, Brazil. ldias@iqm.unicamp.br
de Marchi
Anderson A
AA
Ferreira
Marco A B
MA
Aguilar
Andrea M
AM