title: Multifeature prostate cancer diagnosis and Gleason grading of histological images.
abstract: We present a study of image features for cancer diagnosis and Gleason grading of the histological images of prostate. In diagnosis, the tissue image is classified into the tumor and nontumor classes. In Gleason grading, which characterizes tumor aggressiveness, the image is classified as containing a low- or high-grade tumor. The image sets used in this paper consisted of 367 and 268 color images for the diagnosis and Gleason grading problems, respectively, and were captured from representative areas of hematoxylin and eosin-stained tissue retrieved from tissue microarray cores or whole sections. The primary contribution of this paper is to aggregate color, texture, and morphometric cues at the global and histological object levels for classification. Features representing different visual cues were combined in a supervised learning framework. We compared the performance of Gaussian, k-nearest neighbor, and support vector machine classifiers together with the sequential forward feature selection algorithm. On diagnosis, using a five-fold cross-validation estimate, an accuracy of 96.7% was obtained. On Gleason grading, the achieved accuracy of classification into low- and high-grade classes was 81.0%.
authors.affiliation: Aureon Laboratories, Inc., Yonkers, NY 10701, USA. ali.tabesh@aureon.com
authors.forename: Ali
authors.initials: A
authors.lastname: Tabesh
authors.forename: Mikhail
authors.initials: M
authors.lastname: Teverovskiy
authors.forename: Ho-Yuen
authors.initials: HY
authors.lastname: Pang
authors.forename: Vinay P
authors.initials: VP
authors.lastname: Kumar
authors.forename: David
authors.initials: D
authors.lastname: Verbel
authors.forename: Angeliki
authors.initials: A
authors.lastname: Kotsianti
authors.forename: Olivier
authors.initials: O
authors.lastname: Saidi
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003116:Color; D003124:Colorimetry / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods*; D011471:Prostatic Neoplasms / Q000145:classification* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity