title: Measurement techniques for tracer kinetic studies with stable isotopes of zirconium.
abstract: Biokinetic models are used in radiation protection to assess internal radiation doses. Experiments with stable isotopes as tracers can be performed to obtain characteristic parameters of these models. Two methods for the measurement of zirconium isotopes in human biological samples are presented--thermal ionisation mass spectrometry (TIMS) and proton nuclear activation analysis (PNA). Descriptions include sample preparation, operating conditions, relative uncertainties and method detection limits as well as important properties of both methods.
authors.affiliation: GSF-National Research Center for Environment and Health, 85764 Neuherberg, Germany. matthias.greiter@gsf.de
authors.forename: M
authors.initials: M
authors.lastname: Greiter
authors.forename: K
authors.initials: K
authors.lastname: Abbas
authors.forename: M C
authors.initials: MC
authors.lastname: Cantone
authors.forename: W
authors.initials: W
authors.lastname: Carli
authors.forename: A
authors.initials: A
authors.lastname: Geisler
authors.forename: U
authors.initials: U
authors.lastname: Gerstmann
authors.forename: A
authors.initials: A
authors.lastname: Giussani
authors.forename: R
authors.initials: R
authors.lastname: Hertenberger
authors.forename: U
authors.initials: U
authors.lastname: Holzwarth
authors.forename: O
authors.initials: O
authors.lastname: Meisenberg
authors.forename: V
authors.initials: V
authors.lastname: Höllriegl
authors.forename: U
authors.initials: U
authors.lastname: Oeh
authors.forename: I
authors.initials: I
authors.lastname: Veronese
authors.forename: H G
authors.initials: HG
authors.lastname: Paretzke
mesh_terms: D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D007554:Isotopes / Q000032:analysis / Q000493:pharmacokinetics; D007700:Kinetics; D008954:Models, Biological; D011829:Radiation Dosage; D012062:Relative Biological Effectiveness; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*; D015040:Zirconium / Q000032:analysis* / Q000493:pharmacokinetics*
chemical_list: D007554:Isotopes; D015040:Zirconium