title: Hyperaldosteronism: a commonly occurring underlying feature of essential hypertension and the metabolic syndrome?
abstract: Individuals with primary aldosteronism make up a substantial proportion of those with hypertension. Less well appreciated is what appears to be inappropriately elevated aldosterone secretion in hypertensive patients who do not meet the criteria for true primary aldosteronism. This finding is particularly true of African-Americans. An additional, recently described, aspect of aldosterone excess is its apparent contribution to insulin resistance as evidenced by the frequent association of primary aldosteronism with the metabolic syndrome. Thus in the management of, not only hypertension, but also certain metabolic conditions, greater consideration should be given to the participation of aldosterone.
authors.affiliation: Department of Medicine, Indiana University School of Medicine and the VA Medical Center, Indianapolis, Indiana, USA.
authors.forename: Tae-Yon
authors.initials: TY
authors.lastname: Chun
authors.forename: J Howard
authors.initials: JH
authors.lastname: Pratt
mesh_terms: D001741:Black or African American; D000450:Aldosterone / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000208:ethnology / Q000628:therapy; D006973:Hypertension / Q000150:complications* / Q000208:ethnology / Q000378:metabolism / Q000628:therapy; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications* / Q000628:therapy
chemical_list: D000450:Aldosterone