title: Inheritance and perinatal consequences of inherited thrombophilia in Greece.
abstract: OBJECTIVE
  To investigate the impact of inherited thrombophilic factors on the gestational outcome of unselected pregnant women.
  
  
  METHODS
  A total of 392 women with spontaneous pregnancy were investigated for Factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations. Adverse pregnancy outcomes were recorded.
  
  
  RESULTS
  Thrombophilic genotypes were significantly higher in women with placental abruption. Heterozygocity for Factor V Leiden increased the risk for placental abruption 9.1 times. The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels. Women with inherited thrombophilia and previous obstetric complications were at significant risk for complications in a subsequent pregnancy (P<0.05).
  
  
  CONCLUSIONS
  Women with placental abruption should be screened for thrombophilic factors and plasma homocysteine should be measured. Subgroups of women with inherited thrombophilia and obstetric complications might benefit from prophylactic anticoagulation in subsequent pregnancies.
authors.affiliation: Department of Internal Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece. makara@med.upatras.gr
authors.forename: Marina
authors.initials: M
authors.lastname: Karakantza
authors.forename: Georgios
authors.initials: G
authors.lastname: Androutsopoulos
authors.forename: Athina
authors.initials: A
authors.lastname: Mougiou
authors.forename: Georgios
authors.initials: G
authors.lastname: Sakellaropoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Kourounis
authors.forename: Georgios
authors.initials: G
authors.lastname: Decavalas
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000235:genetics; D000037:Abruptio Placentae / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications* / Q000453:epidemiology; D005165:Factor V / Q000235:genetics; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D016017:Odds Ratio; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000150:complications / Q000453:epidemiology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)