[Expression of TR4-associated protein in non-small cell lung cancer].
OBJECTIVE
To investigate the expression and significance of TR4-associated Protein (TRA16) in human non-small cell lung cancer (NSCLC) tissues.


METHODS
Immunohistochemistry (IHC) and tissue array were employed to investigate the expression of TRA16 in NSCLC cases of different pathological types, benign lung lesions and normal lung tissues.


RESULTS
The abundant expression of TRA16 was observed in nucleus and/or cytoplasm of NSCLC cells with a positive expression rate of 88.64%, whereas normal lung tissue and benign lung tumor rarely expressed TRA16 protein. The expression of TRA16 showed no apparent difference at pathotypes and differentiation levels.


CONCLUSIONS
In this study we demonstrated an abnormal overexpression of TRA16 in NSCLC tissues. The unique expression pattern of TRA16 indicated its probable role in tumorigenesis and progression, supporting the development of TRA16 as a novel potential NSCLC marker.
Zheng
Qing-Feng
QF
Department of Thoracic Surgery, Peking University School of Oncology, Beijing Cancer Hospital Institute, Beijing 100036, China.
Dong
Bin
B
Sun
Yu
Y
DU
Hong
H
Xiong
Hong-Chao
HC
Wu
Nan
N
Chen
Jin-Feng
JF
Sun
Lu
L
Ao
Jie
J
Li
Ji-You
JY
Ji
Jia-Fu
JF
Yang
Yue
Y
D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*
C472782:NR2C2AP protein, human; D009687:Nuclear Proteins; D012097:Repressor Proteins