Highly sensitive fluorescent probes for zinc ion based on triazolyl-containing tetradentate coordination motifs.
Two new 1,2,3-triazolyl-containing N4-tetradentate ligands show nanomolar affinity for Zn2+ under physiological conditions. Furthermore, they are easily derivatizable to afford fluorescent probes suitable for sensitive Zn2+ detection. Structural characterizations in both solid and solution states suggest that N3 and N2 in the 1,2,3-triazolyl moiety coordinate with Zn2+ in A and B to afford five-membered and six-membered coordination rings, respectively. The probes show sensitive fluorescence enhancement and ratiometric responses to Zn2+.
Huang
Sha
S
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.
Clark
Ronald J
RJ
Zhu
Lei
L
D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D014230:Triazoles; D015032:Zinc