New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes.
Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.
Xu
Lan-Lan
LL
Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. llxu@ctgu.edu.cn
Zou
Kun
K
Wang
Jun-Zhi
JZ
Wu
Jun
J
Zhou
Yuan
Y
Dan
Fei-Jun
FJ
Yang
Jing
J
D000818:Animals; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
C524610:5-furost-delta(25(27))-en-1,2,3,4,5,6,7,22zeta,26-nonaol-26-O-glucopyranoside; C524609:5-furost-delta(25(27))-en-1,2,3,4,5,7,22zeta,26-octaol-6-one-26-O-glucopyranoside; D008070:Lipopolysaccharides; D012503:Saponins; D009569:Nitric Oxide