title: Effectiveness of maintenance bee venom immunotherapy administered at 6-month intervals.
abstract: BACKGROUND
  Extension of the intervals at which maintenance venom immunotherapy (MVIT) is administered has been attempted for many years. However, published evidence on its effect, especially in intervals of longer than 3 months, is sparse.
  
  
  OBJECTIVE
  To examine whether the administration of a bee venom (BV) maintenance dose at 6-month intervals is safe and efficacious.
  
  
  METHODS
  The 3-month intervals at which venom-allergic patients were receiving their MVIT were gradually extended to 6 months. Systemic reactions (SRs) to immunotherapy injections or to field stings were regularly recorded. Patients who were allergic to BV alone or also to other venoms were deliberately sting challenged by a honeybee after reaching the 6-month interval.
  
  
  RESULTS
  The 3-month intervals were extended in 47 patients. A single patient (2%) developed an SR after receiving the injection at an interval of 4 months. Two field stings in 2 patients resulted in a mild SR in 1 patient. Of 14 sting-challenged patients, 3 (21%) developed an SR after the challenge. The 3 SRs occurred only among the 8 patients (38%) who were allergic to BV alone. The 3 patients with the SR to the challenge continued to receive the regular maintenance dose at monthly intervals 3 to 5 more times. Repeated sting challenges were then well tolerated in all 3 patients.
  
  
  CONCLUSIONS
  The administration of MVIT at 6-month intervals does not provide suitable protection in BV-allergic patients, and they should continue MVIT at the accepted 1- to 3-month intervals.
authors.affiliation: Allergy and Clinical Immunology Unit, Meir Hospital, Kfar-Saba, Israel. arnong@clalit.org.il
authors.forename: Arnon
authors.initials: A
authors.lastname: Goldberg
authors.forename: Ronit
authors.initials: R
authors.lastname: Confino-Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001514:Bee Venoms / Q000008:administration & dosage* / Q000276:immunology / Q000627:therapeutic use; D002648:Child; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000517:prevention & control*; D007299:Insect Bites and Stings / Q000276:immunology; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001514:Bee Venoms