ImmunoCell-Array: a novel technology for pathway discovery and cell profiling.
A major challenge in drug discovery is the definition of the activity of therapeutic compounds before they enter clinical trials. Currently, many tools are available to profile drug response at a multiparametric level. Furthermore, the novel discipline of systems biology is offering interpretative cues to the amount of data generated by the so-called omics technologies. Nonetheless, novel approaches are needed to comprehensively evaluate drug response. This review will describe a recent technology for protein profiling, the ImmunoCell-Array, which, in to the authors' opinion, can enter the scenario of profiling technologies with the goal of offering a comprehensive description of proteome dynamics in a cellular context.
Giorgetti
Luca
L
IFOM-IEO Campus, Via Adamello, 16-20139 Milan, Italy. luca.giorgetti@ifom-ieo-campus.it
Zanardi
Andrea
A
Venturini
Samuele
S
Carbone
Roberta
R
D000818:Animals; D020869:Gene Expression Profiling / Q000191:economics / Q000379:methods*; D006801:Humans; D007118:Immunoassay / Q000191:economics / Q000379:methods*; D020543:Proteome / Q000032:analysis*; D046888:Tissue Array Analysis / Q000191:economics / Q000379:methods*
D020543:Proteome