title: Robust blood-glucose control using Mathematica.
abstract: A robust control design on frequency domain using Mathematica is presented for regularization of glucose level in type I diabetes persons under intensive care. The method originally proposed under Mathematica by Helton and Merino, --now with an improved disturbance rejection constraint inequality--is employed, using a three-state minimal patient model. The robustness of the resulted high-order linear controller is demonstrated by nonlinear closed loop simulation in state-space, in case of standard meal disturbances and is compared with H infinity design implemented with the mu-toolbox of Matlab. The controller designed with model parameters represented the most favorable plant dynamics from the point of view of control purposes, can operate properly even in case of parameter values of the worst-case scenario.
authors.affiliation: Dept. of Control Engineering and Information Technology, Budapest University of Technology and Economics, Hungary.
authors.forename: Levente
authors.initials: L
authors.lastname: Kovács
authors.forename: Béla
authors.initials: B
authors.lastname: Paláncz
authors.forename: Balázs
authors.initials: B
authors.lastname: Benyó
authors.forename: László
authors.initials: L
authors.lastname: Török
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Benyó
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D008954:Models, Biological; D011381:Programming Languages; D012984:Software
chemical_list: D001786:Blood Glucose; D007328:Insulin