title: Assembly of motor circuits in the spinal cord: driven to function by genetic and experience-dependent mechanisms.
abstract: Motor circuits in the spinal cord integrate information from various sensory and descending pathways to control appropriate motor behavior. Recent work has revealed that target-derived retrograde signaling mechanisms act to influence sequential assembly of motor circuits through combinatorial action of genetic and experience-driven programs. These parallel activities imprint somatotopic information at the level of the spinal cord in precisely interconnected circuits and equip animals with motor circuits capable of reacting to changing demands throughout life.
authors.affiliation: Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
authors.forename: David R
authors.initials: DR
authors.lastname: Ladle
authors.forename: Eline
authors.initials: E
authors.lastname: Pecho-Vrieseling
authors.forename: Silvia
authors.initials: S
authors.lastname: Arber
mesh_terms: D000818:Animals; D004525:Efferent Pathways / Q000502:physiology*; D015870:Gene Expression; D008954:Models, Biological; D009046:Motor Neurons / Q000502:physiology*; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000502:physiology*
chemical_list: D017475:Receptors, Nerve Growth Factor