title: Clinical features and outcome of community-onset bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli.
abstract: This study was conducted to evaluate the epidemiology and clinical features of bloodstream infections caused by extended-spectrum beta-lactamase-producing E. coli (ESBL-EC) in community-onset bacteremia. Of 929 episodes of community-onset E. coli bacteremia, 4.1% (38/929) had bacteremia with ESBL producers. Of these, 63.2% (24/38) were further classified as healthcare-associated infections. Although most patients had risk factors for infection due to ESBL producers, three patients with urinary tract infection, four patients with cholangitis, and one patient with a liver abscess had no identified predisposing risk factors. The 30-day mortality was 21.1% (8/38). ESBL-EC is a significant cause of bloodstream infection, even in patients with community-onset infection.
authors.affiliation: Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 ILwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
authors.forename: C-I
authors.initials: CI
authors.lastname: Kang
authors.forename: H S
authors.initials: HS
authors.lastname: Cheong
authors.forename: D R
authors.initials: DR
authors.lastname: Chung
authors.forename: K R
authors.initials: KR
authors.lastname: Peck
authors.forename: J-H
authors.initials: JH
authors.lastname: Song
authors.forename: M-D
authors.initials: MD
authors.lastname: Oh
authors.forename: K-W
authors.initials: KW
authors.lastname: Choe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*; D004926:Escherichia coli / Q000201:enzymology / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D001618:beta-Lactamases