title: Models of selective stimulation with a flat interface nerve electrode for standing neuroprosthetic systems.
abstract: The long-term goal of our research is to restore standing function via selective activation of target fascicles in the femoral nerve by a flat interface nerve electrode (FINE). The optimal number and location of contacts within a FINE had not been determined previously. A realistic three-dimensional finite element model based on a cross section of human femoral nerve and FINE is presented. Simulated voltages are applied as an extracellular field to the MRG double-cable axon model. Initial simulations indicate that optimal contacts may exist for each fascicular group but an acceptable selectivity may require nerve reshaping.
authors.affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH 44106, USA. Matthew.Schiefer@case.edu
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Schiefer
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Triolo
authors.forename: Dustin J
authors.initials: DJ
authors.lastname: Tyler
mesh_terms: D004558:Electric Stimulation; D004566:Electrodes; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D009132:Muscles / Q000473:pathology; D009417:Nerve Tissue / Q000473:pathology*; D017933:Peripheral Nervous System; D012680:Sensitivity and Specificity