title: Rebound of psoriasis after efalizumab discontinuation, despite being on high-dose cyclosporine.
abstract: Psoriasis rebound after efalizumab discontinuation is well-documented in the literature. We report the case of a patient who experienced psoriasis rebound 2 months after efalizumab discontinuation, despite being on more than 5 mg/kg/day of cyclosporine. This case illustrates an instance where high doses of a very efficacious antipsoriasis therapy were not sufficient to prevent efalizumab-associated rebound. In addition to describing this case, we also propose a theoretical mechanism to explain how rebound after efalizumab discontinuation comes about.
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Zahida Khan
authors.initials: ZK
authors.lastname: Maskatia
authors.forename: John
authors.initials: J
authors.lastname: Koo
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D016572:Cyclosporine / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors; D028761:Withholding Treatment
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003879:Dermatologic Agents; D016572:Cyclosporine; C472181:efalizumab