Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections.
Gentamicin is an aminoglycoside with a wide spectrum of antibacterial activity. However, as a highly water-soluble drug, it penetrates cells poorly. This constitutes a particularly important drawback for treating intracellular bacterial infections. This major hurdle may be solved by the use of vectors to deliver and target bioactive agents to the intracellular sites of infection. Thus, in the case of antimicrobials, drug delivery systems may help to increase their therapeutic index in intracellular locations. The development and evolution of pharmaceutical forms of gentamicin for the parenteral treatment of intracellular pathogens is reviewed in this paper.
Gamazo
Carlos
C
University of Navarra, Department of Microbiology, 31080 Pamplona, Spain. cgamazo@unav.es
Prior
Sandra
S
Concepción Lecároz
María
M
Vitas
Ana Isabel
AI
Campanero
Miguel Angel
MA
Pérez
Guiomar
G
Gonzalez
David
D
Blanco-Prieto
María Jose
MJ
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008081:Liposomes; D053758:Nanoparticles / Q000737:chemistry
D004337:Drug Carriers; D005839:Gentamicins; D008081:Liposomes