Chronic phenobarbital-induced mitochondrial pleomorphism in the rat liver.
Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.
Almsherqi
Zakaria
Z
Department of Physiology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore 117597.
McLachlan
Craig Steven
CS
Tay
Stacey K H
SK
Deng
Yuru
Y
D000818:Animals; D008297:Male; D046529:Microscopy, Electron, Transmission; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D010634:Phenobarbital / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D010634:Phenobarbital