Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library.
A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC(90) value of 12.5 microg/mL.
Sun
Dianqing
D
Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jones
Victoria
V
Carson
Elizabeth I
EI
Lee
Robin E B
RE
Scherman
Michael S
MS
McNeil
Michael R
MR
Lee
Richard E
RE
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019151:Peptide Library; D013329:Structure-Activity Relationship; D014529:Uridine / Q000737:chemistry*
D000995:Antitubercular Agents; D019151:Peptide Library; D014529:Uridine