title: A clinical procedure for case-specific analytical validation of mono-modality image fusion in image guided radiotherapy.
abstract: Image guided radiotherapy can be performed by fusing the daily treatment and reference planning computed tomography scans. Decreased errors in patient setup can lead to smaller target margins that significantly improve treatment efficacy and outcome. The purpose of this work is to present a clinical procedure to analytically compute the accuracy of the registration. Accepted techniques such as normalized mutual information intensity based three-dimensional image registration can be validated using a large automated point sample. Without a user independent metric it is not possible to determine effect of the fusion error on the calculated correction in patient setup.
authors.affiliation: Dept. of Radiat. Oncology, Hackensack Univ. Med. Center, NJ 07601, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Hanley
authors.forename: Joseph
authors.initials: J
authors.lastname: Barbiere
authors.forename: Yulin
authors.initials: Y
authors.lastname: Song
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted; D011878:Radiotherapy / Q000379:methods*; D015203:Reproducibility of Results; D012886:Skull / Q000000981:diagnostic imaging*; D012984:Software; D013131:Spine / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome