title: Implantation of an elastic ring at equator of the left ventricle influences cardiac mechanics in experimental acute ventricular dysfunction.
abstract: OBJECTIVE
  We hypothesize that the implantation of an endoventricular elastic ring at the left ventricle (LV) equatorial site will positively affect the cardiac mechanics in an experimental model of acute LV dysfunction.
  
  
  BACKGROUND
  Changes in the elastic properties of LV occur in the dilated and failing heart, contributing to overall cardiac mechanical dysfunction. No interventions are as yet specifically designed to improve LV elasticity in failing hearts.
  
  
  METHODS
  Acute LV enlargement and dysfunction was induced in 13 healthy sheep via the insertion of a large Dacron patch into the lateral wall. In 6 of these sheep, a customized elastic ring was implanted at the inner surface of the LV equator (ring group), and the remaining 7 served as control subjects (dysfunction group). Systolic and diastolic function was evaluated using echocardiography and pressure-volume (P-V) analysis.
  
  
  RESULTS
  In the ring group, both the maximum rate of pressure increase and the slope of end-systolic P-V relationship were significantly different from those without ring (1,718 +/- 726 vs. 1,049 +/- 269 and 1.25 +/- 0.30 vs. 0.88 +/- 0.19; both p < 0.05). Preload recruitable stroke work changed even more prominently (33 +/- 11 vs. 17 +/- 5; p = 0.005), along with stroke volume, ejection fraction, and stroke work. Although ring implantation had no effect on end-diastolic P-V relationship, it positively affected the active component of diastole: the maximum rate of pressure decrease declined significantly (p = 0.037). The time constant of relaxation tended to decrease (37 +/- 8 vs. 44 +/- 6; p = 0.088).
  
  
  CONCLUSIONS
  Improving the elastic component of the LV at its equatorial site substantially augments contractility and early relaxation in acute systodiastolic LV dysfunction.
authors.affiliation: Dipartimento Cardiovascolare Clinico e di Ricerca, Bergamo, Italy. pferrazzi@ospedaliriuniti.bergamo.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrazzi
authors.forename: Michele
authors.initials: M
authors.lastname: Senni
authors.forename: Maria R
authors.initials: MR
authors.lastname: Iascone
authors.forename: Maurizio
authors.initials: M
authors.lastname: Merlo
authors.forename: Michele
authors.initials: M
authors.lastname: Triggiani
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorusso
authors.forename: Paul
authors.initials: P
authors.lastname: Herijgers
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Schreuder
authors.forename: Samuele
authors.initials: S
authors.lastname: Pentiricci
authors.forename: Attilio
authors.initials: A
authors.lastname: Iacovoni
authors.forename: Eugenio
authors.initials: E
authors.lastname: Quaini
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004548:Elasticity; D020007:Implants, Experimental; D009200:Myocardial Contraction / Q000502:physiology*; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D012756:Sheep; D013193:Stainless Steel; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D011093:Polyethylene Terephthalates; D013193:Stainless Steel