title: The clinical and pathological differences in prevalent round screen-detected and symptomatic invasive breast cancer.
abstract: The potential benefits of breast cancer screening include the detection of cancers at a more favourable stage, however, cancers detected during the prevalent round of screening may differ from true screen-detected cancers. These differences are poorly defined. This study prospectively assessed all women between 50 and 64 years of age undergoing curative surgery for breast cancer, both screen-detected and symptomatic, in one screening centre during the prevalent round of the national breast cancer-screening programme. Four hundred and thirty seven patients (364 screen-detected and 73 symptomatic patients) underwent surgery for breast cancer. Symptomatic breast cancers were of a higher grade (p < 0.0001; Chi2) and less likely to be oestrogen receptor positive (49% versus 88%; p < 0.0001; Fisher's exact test); however there was no difference in size of tumour or axillary nodal positivity. This study suggests that tumours detected by screening during the prevalent round of a screening programme are of a more prognostically favourable type than symptomatic breast cancers in the same age group.
authors.affiliation: Department of Surgery, Mater Misericordiae Hospital, Eccles Street, Dublin 7. karlsweeney@eircom.net
authors.forename: K J
authors.initials: KJ
authors.lastname: Sweeney
authors.forename: M R
authors.initials: MR
authors.lastname: Kell
authors.forename: N A
authors.initials: NA
authors.lastname: Aziz
authors.forename: N
authors.initials: N
authors.lastname: Prunty
authors.forename: P
authors.initials: P
authors.lastname: Holloway
authors.forename: M
authors.initials: M
authors.lastname: Kennedy
authors.forename: F
authors.initials: F
authors.lastname: Flanagan
authors.forename: M J
authors.initials: MJ
authors.lastname: Kerin
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome