pH-Controllable drug release using hydrogel encapsulated mesoporous silica.
Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of protein drug to the site of higher pH value, such as small intestine or colon.
Song
S-W
SW
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 119260.
Hidajat
K
K
Kawi
S
S
D000180:Acrylic Resins / Q000737:chemistry; D002942:Circular Dichroism; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
D000180:Acrylic Resins; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011506:Proteins; D013778:Tetrazolium Salts; D013844:Thiazoles; D012710:Serum Albumin, Bovine; C006903:carbopol 940; D012822:Silicon Dioxide; C022616:thiazolyl blue