title: [Expression of vascular endothelial growth factor and metastin in colorectal carcinoma].
abstract: OBJECTIVE
  To study the expression of vascular endothelial growth factor (VEGF) and metastin in colorectal carcinoma and their association with the clinicopathological features of the malignancy.
  
  
  METHODS
  VEGF and metastin expressions were examined immunohistochemically with SP method in 70 specimens of human colorectal carcinoma tissues and adjacent normal tissues.
  
  
  RESULTS
  VEGF protein overexpression was detected in 48.6% (34/70)of the colorectal carcinoma tissues but in none of the adjacent normal tissues (P<0.01), and for metastin, the overexpression rate was 28.6% (20/70) in the colorectal carcinoma tissues and 70.0% (49/70) in the normal tissues (P<0.01). The expression of both VEGF and metastin was related to the histological grades, infiltration depth, TNM stage and lymph node metastasis of the tumor (P<0.01 and P<0.05, respectively).
  
  
  CONCLUSIONS
  Immunohistochemical detection of VEGF and metastin can be of value in assessment of the malignancy and in prognostic evaluation of colorectal carcinoma.
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. lianqilian@gdmc.edu.cn
authors.forename: Qi-Lian
authors.initials: QL
authors.lastname: Liang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Chen
authors.forename: San-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Huang
authors.forename: Yan-Yun
authors.initials: YY
authors.lastname: Xu
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D059648:Kisspeptins; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins; D042461:Vascular Endothelial Growth Factor A