Detection of lung cancer with phase-contrast X-ray imaging using synchrotron radiation.
In the present study, the feasibility of applying synchrotron radiation for the detection of lung cancers was investigated. Lung cancer tissues grown in mice over different periods were observed with phase-contrast synchrotron X-ray chest imaging. Irregular and tortuous vessels appearing in early cancer angiogenesis were found in the periphery region of the implanted cancer. Structure difference was clearly shown between normal tissue and early stage solid cancer in micrometers. Results from this study indicate that synchrotron X-ray may open broad perspectives for imaging cancer development and progression noninvasively.
Liu
Ping
P
Sch. of Life Sci. & Technol., Shanghai Jiao Tong Univ, Shanghai PR China.
Sun
Jianqi
J
Guan
Yijing
Y
Zhang
Guilin
G
Xu
Lisa Xuemin
LX
D000818:Animals; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017356:Synchrotrons