Real-time MR imaging of myocardial regional function using strain-encoding (SENC) with tissue through-plane motion tracking.
OBJECTIVE
To implement real-time myocardial strain-encoding (SENC) imaging in combination with tracking the tissue displacement in the through-plane direction.


METHODS
SENC imaging was combined with the slice-following technique by implementing three-dimensional (3D) selective excitation. Certain adjustments were implemented to reduce scan time to one heartbeat. A total of 10 volunteers and five pigs were scanned on a 3T MRI scanner. Spatial modulation of magnetization (SPAMM)-tagged images were acquired on planes orthogonal to the SENC planes for comparison. Myocardial infarction (MI) was induced in two pigs and the resulting SENC images were compared to standard delayed-enhancement (DE) images.


RESULTS
The strain values computed from SENC imaging with slice-following showed significant difference from those acquired without slice-following, especially during systole (P < 0.01). The strain curves computed from the SENC images with and without slice-following were similar to those computed from the orthogonal SPAMM images, with and without, respectively, tracking the tag line displacement in the strain direction. The resulting SENC images showed good agreement with the DE images in identifying MI in infarcted pigs.


CONCLUSIONS
Correction of through-plane motion in real-time cardiac functional imaging is feasible using slice-following. The strain measurements are more accurate than conventional SENC measurements in humans and animals, as validated with conventional MRI tagging.
Ibrahim
El-Sayed H
el-SH
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA. sayed@jhu.edu
Stuber
Matthias
M
Fahmy
Ahmed S
AS
Abd-Elmoniem
Khaled Z
KZ
Sasano
Tetsuo
T
Abraham
M Roselle
MR
Osman
Nael F
NF
D000818:Animals; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009068:Movement; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000175:diagnosis*; D019047:Phantoms, Imaging; D013552:Swine