title: Near-infrared spectroscopic measurements of blood analytes using multi-layer perceptron neural networks.
abstract: Near-infrared (NIR) spectroscopy is being applied to the solution of problems in many areas of biomedical and pharmaceutical research. In this paper we investigate the use of NIR spectroscopy as an analytical tool to quantify concentrations of urea, creatinine, glucose and oxyhemoglobin (HbO2). Measurements have been made in vitro with a portable spectrometer developed in our labs that consists of a two beam interferometer operating in the range of 800-2300 nm. For the data analysis a pattern recognition philosophy was used with a preprocessing stage and a multi-layer perceptron (MLP) neural network for the measurement stage. Results show that the interferogram signatures of the above compounds are sufficiently strong in that spectral range. Measurements of three different concentrations were possible with mean squared error (MSE) of the order of 10(-6).
authors.affiliation: Hamilton Inst., Nat. Univ. of Ireland, Maynooth, Ireland.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kalamatianos
authors.forename: Panos
authors.initials: P
authors.lastname: Liatsis
authors.forename: Peter E
authors.initials: PE
authors.lastname: Wellstead
mesh_terms: D001698:Biomedical Engineering; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data*; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D006801:Humans; D007368:Interferometry / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D016571:Neural Networks, Computer; D010108:Oxyhemoglobins / Q000032:analysis; D012815:Signal Processing, Computer-Assisted; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data*; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D010108:Oxyhemoglobins; D014508:Urea; D003404:Creatinine