Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives.
Several 1,8-naphthyridine-3-carboxamide derivatives (8-23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC(50)=1.37microM) in HBL-100 (breast) cell line while compounds 17 (IC(50)=3.7microM) and 22 (IC(50)=3.0microM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.
Srivastava
Sanjay K
SK
Division of Medicinal Chemistry, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad, 201 010 UP, India.
Jaggi
Manu
M
Singh
Anu T
AT
Madan
Alka
A
Rani
Nidhi
N
Vishnoi
Manupriya
M
Agarwal
Shiv K
SK
Mukherjee
Rama
R
Burman
Anand C
AC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D020014:K562 Cells; D007624:KB Cells; D051379:Mice; D041681:NIH 3T3 Cells; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D018836:Inflammation Mediators; D009287:Naphthyridines