DRAK2 regulates memory T cell responses following murine coronavirus infection.
The contribution of DRAK2 [death-associated protein kinase (DAPK)-related apoptosis-inducing kinase 2] to anti-viral memory T cell responses following infection with mouse hepatitis virus (MHV) was examined. DRAK2 is a lymphoid-enriched serine/threonine kinase that is an important regulatory molecule involved in modulating T cell responses. Memory T cells derived from MHV-immunized Drak2(-/-) mice exhibited amplified proliferation and IFN-gamma secretion following stimulation with viral epitopes. Transfer of Drak2(-/-) memory T cells into Rag1(-/-) mice infected intracerebrally with MHV resulted in accelerated clearance of virus from the brain. Thus, DRAK2 may be a novel target for stimulating protective immunity to viral pathogens.
Schaumburg
Chris S
CS
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Gatzka
Martina
M
Walsh
Craig M
CM
Lane
Thomas E
TE
D000818:Animals; D001921:Brain / Q000276:immunology / Q000821:virology; D049109:Cell Proliferation; D018352:Coronavirus Infections / Q000235:genetics / Q000276:immunology*; D018792:Encephalitis, Viral / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D018398:Homeodomain Proteins / Q000235:genetics / Q000276:immunology; D007114:Immunization; D007156:Immunologic Memory / Q000235:genetics; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D006517:Murine hepatitis virus / Q000276:immunology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D018398:Homeodomain Proteins; C064658:RAG-1 protein; D007371:Interferon-gamma; C495197:Drak2 protein, mouse; D017346:Protein Serine-Threonine Kinases