title: Enhanced bone regeneration in beagle dogs with bovine bone mineral coated with a synthetic oligopeptide.
abstract: BACKGROUND
  Recombinant human bone morphogenic protein-2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3-wall defect model and the clinical implications.
  
  
  METHODS
  The second and fourth mandibular premolars of four adult beagle dogs were extracted bilaterally, and the extraction sites were allowed to heal for 2 months. An L-shaped defect was prepared at the central part of the extraction site with a round bur on a low-speed motor. Peptide-coated bone mineral was implanted on one side, and uncoated bone mineral was implanted on the other side. The membrane was tucked underneath the mobilized lingual flap. New bone formation at the test and control sites was determined at 4 weeks.
  
  
  RESULTS
  No specimen revealed any evidence of infection or foreign body reaction, and all wounds showed a good healing response. Sites augmented with peptide-coated bone mineral and uncoated mineral exhibited excellent maintenance of the ridge contour. There was more new bone at sites with peptide-coated bone mineral than at control sites. The new bone in sites with peptide-coated bone mineral was deposited evenly around the graft material, and bone mineral was integrated fully into the new bone.
  
  
  CONCLUSIONS
  Deproteinized cancellous bovine bone coated with synthetic oligopeptides enhanced new bone formation, and it seemed to be a better material for guided bone regeneration in the beagle L-shaped defect model.
authors.affiliation: Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Jun-Beom
authors.initials: JB
authors.lastname: Park
authors.forename: Jue-Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Yoon-Jeong
authors.initials: YJ
authors.lastname: Park
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Rhee
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Lee
authors.forename: Tae-Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Yang-Jo
authors.initials: YJ
authors.lastname: Seol
authors.forename: Yong-Moo
authors.initials: YM
authors.lastname: Lee
authors.forename: Young
authors.initials: Y
authors.lastname: Ku
authors.forename: In-Chul
authors.initials: IC
authors.lastname: Rhyu
authors.forename: Soo-Boo
authors.initials: SB
authors.lastname: Han
authors.forename: Chong-Pyoung
authors.initials: CP
authors.lastname: Chung
mesh_terms: D000539:Alveolar Process / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D009842:Oligopeptides / Q000627:therapeutic use*
chemical_list: D018786:Bone Substitutes; D009842:Oligopeptides