title: Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors.
abstract: Disruption of lipopolysaccharide (LPS) biosynthesis genes in an epidemiologically significant Yersinia pestis strain showed that the ability to synthesize the full inner core of the LPS is crucial for resistances to the bactericidal action of antimicrobial peptides and to complement-mediated serum killing. Resistance to polymyxin B also requires a high content of the cationic sugar, 4-amino-4-deoxy-L-arabinose, in lipid A.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. knirel@ioc.ac.ru
authors.forename: Yuriy A
authors.initials: YA
authors.lastname: Knirel
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Dentovskaya
authors.forename: Olga V
authors.initials: OV
authors.lastname: Bystrova
authors.forename: Nina A
authors.initials: NA
authors.lastname: Kocharova
authors.forename: Sof'ya N
authors.initials: SN
authors.lastname: Senchenkova
authors.forename: Rima Z
authors.initials: RZ
authors.lastname: Shaikhutdinova
authors.forename: Galina M
authors.initials: GM
authors.lastname: Titareva
authors.forename: Irina V
authors.initials: IV
authors.lastname: Bakhteeva
authors.forename: Buko
authors.initials: B
authors.lastname: Lindner
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Pier
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Anisimov
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D001770:Blood Bactericidal Activity; D002240:Carbohydrate Sequence; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009154:Mutation; D011112:Polymyxin B / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D015010:Yersinia pestis / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics
chemical_list: D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D011112:Polymyxin B