title: Treatment of tinnitus with acamprosate.
abstract: Acamprosate, a drug used to treat alcohol dependence, was first reported as a potential treatment for tinnitus in 2005. The drug may improve tinnitus by a dual mechanism of action, acting both as a glutamate antagonist and as a GABA agonist. It is suggested that its action may be both on the ear and the nervous system.
authors.affiliation: OTOSUL, Otorrinolaringologia Sul-Fluminense, Volta Redonda, Vila Santa Cecília, Rio de Janeiro, Brazil. otosul@otosul.com.br
authors.forename: Andréia Aparecida de
authors.initials: AA
authors.lastname: Azevedo
authors.forename: Ricardo Rodrigues
authors.initials: RR
authors.lastname: Figueiredo
mesh_terms: D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000627:therapeutic use*; D018691:Excitatory Amino Acid Antagonists; D018682:GABA Agents / Q000627:therapeutic use; D006801:Humans; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014012:Tinnitus / Q000188:drug therapy*
chemical_list: D000427:Alcohol Deterrents; D018691:Excitatory Amino Acid Antagonists; D018682:GABA Agents; D013654:Taurine; D000077443:Acamprosate