title: Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction.
abstract: An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alpha-exo-methylene indanones depending on the base used.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Minatti
authors.forename: Xiaolai
authors.initials: X
authors.lastname: Zheng
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis*; D008024:Ligands; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*
chemical_list: D007189:Indans; D008024:Ligands; D010165:Palladium