title: Design and fabrication of a flexible substrate microelectrode array for brain machine interfaces.
abstract: We report a neural microelectrode array design that leverages the recording properties of conventional microwire electrode arrays with the additional features of precise control of the electrode geometries. Using microfabrication techniques, a neural probe array is fabricated that possesses a flexible polyimide-based cable. The performance of the design was tested with electrochemical impedance spectroscopy and in vivo studies. The gold-plated electrode site has an impedance value of 0.9 M Omega at 1 kHz. Acute neural recording provided high neuronal yields, peak-to-peak amplitudes (as high as 100 microV), and signal-to-noise ratios (27 dB).
authors.affiliation: Dept. of Electr. Eng., Florida Univ., Gainesville, FL 32611, USA. ee1@ufl.edu
authors.forename: Erin
authors.initials: E
authors.lastname: Patrick
authors.forename: Matthew
authors.initials: M
authors.lastname: Ordonez
authors.forename: Nicolas
authors.initials: N
authors.lastname: Alba
authors.forename: Justin C
authors.initials: JC
authors.lastname: Sanchez
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Nishida
mesh_terms: D000200:Action Potentials; D000818:Animals; D001698:Biomedical Engineering; D001701:Bionics / Q000295:instrumentation; D001921:Brain / Q000502:physiology* / Q000601:surgery*; D004867:Equipment Design; D006801:Humans; D008297:Male; D008328:Man-Machine Systems; D008839:Microelectrodes; D051381:Rats; D017207:Rats, Sprague-Dawley