Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies.
We study the association between three Vitamin D receptor gene polymorphisms (rs10735810, rs1544410, rs731236) and susceptibility to thyroid autoimmune diseases. Seventy-six affected subjects, belonging to a large family, as well as one hundred unrelated Tunisian patients and one hundred healthy Tunisian controls were genotyped. A family-based association test and a standard chi-square test were used to assess association in family and case-control data, respectively. Our results showed no significant association of the Vitamin D receptor gene polymorphisms with the susceptibility to thyroid autoimmune diseases in the family. Moreover, allele frequencies for the three polymorphisms in the Tunisian population were similar to those reported in the Tunisian control population and none was associated with the disease. These results suggest a lack of association between the Vitamin D receptor gene polymorphisms and susceptibility to thyroid autoimmune diseases in Tunisian population, in agreement with data from the UK, but in conflict with studies from the Far East.
Maalej
Abdellatif
A
Faculté de Médecine, Laboratoire de Génétique Moléculaire Humaine, Avenue Majida Boulila, 3029 Sfax, Tunisia. abdellatifmaalej@lycos.com
Petit-Teixeira
Elisabeth
E
Chabchoub
Ghazi
G
Hamad
Mariam Ben
MB
Rebai
Ahmed
A
Farid
Nadir R
NR
Cornelis
Francois
F
Ayadi
Hammadi
H
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006111:Graves Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D013967:Thyroiditis, Autoimmune / Q000235:genetics*; D014416:Tunisia
D018167:Receptors, Calcitriol