Role of activation of cholinergic influences in recovery of electrical activity of the stomach and small intestine during the early postoperative period in rats.
The effects of neostigmine and calcium pantothenate on electrical activity of the stomach and small intestine were studied in chronic experiments on rats after laparotomy with implantation of a probe into the jejunum and electrodes into different portions of the gastrointestinal tract. At the early terms after surgery, stimulation of endogenous acetylcholine release intensified electrical activity of the stomach, duodenum, and jejunum. Treatment with neostigmine and calcium pantothenate did not accelerate the recovery of the migrating myoelectrical complex, but promoted the recovery of the general intensity of action potential generation in the stomach and small intestine.
Tropskaya
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N. V. Sklifosovsky Institute of Urgent Care, Moscow. ntropskaya@mail.ru
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D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004576:Electromyography; D004594:Electrophysiology; D005753:Gastric Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007813:Laparotomy; D016065:Myoelectric Complex, Migrating / Q000187:drug effects* / Q000502:physiology; D009388:Neostigmine / Q000494:pharmacology; D010205:Pantothenic Acid / Q000494:pharmacology; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D010205:Pantothenic Acid; D009388:Neostigmine; D000109:Acetylcholine