title: [Increased plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients].
abstract: OBJECTIVE
  This study investigates the plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients.
  
  
  METHODS
  Patients were scruited according to JNC-7 and divided into three groups: 74 normotensive subjects (NT group, 38 males, mean age 47.15 +/- 7.77 years old); 51 prehypertensive patients (PH group, 29 males, mean age 47.82 +/- 5.16 years old) and 71 essential hypertensive patients (EH group, 37 males, mean age 48.25 +/- 7.97 years old). Serum lipids and plasma angiotensin II (Ang II), endothelin (ET), vasopressin (AVP), calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GPX) by radioimmunoassay and enzyme linked immunosorbent assay.
  
  
  RESULTS
  Serum Lipids (TG, CHO and LDL) were significantly higher in the PH and EH groups compared to NT group (all P < 0.05). Ang II, AVP and ET were significantly increased while CGRP decreased in the EH group than that in NT group (all P < 0.05). SOD was significantly lower while GPX significantly higher. Further more, in the PH and EH groups than those in the NT group (all P < 0.05).
  
  
  CONCLUSIONS
  SOD was reduced and GPX increased in prehypertensive patients.
authors.affiliation: Division of Hypertension, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing Institute of Heart, Lung, Vessel Diseases, Beijing 100029, China.
authors.forename: Zuo-guang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Jie-lin
authors.initials: JL
authors.lastname: Liu
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Shao-jun
authors.initials: SJ
authors.lastname: Wen
authors.forename: Jie
authors.initials: J
authors.lastname: Wen
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Xin-jun
authors.initials: XJ
authors.lastname: Chen
authors.forename: Zhao-su
authors.initials: ZS
authors.lastname: Wu
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D000975:Antioxidants; D001794:Blood Pressure / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D016022:Case-Control Studies; D016232:Endothelins / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000097:blood; D010949:Plasma / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood*; D014667:Vasopressins / Q000097:blood
chemical_list: D000975:Antioxidants; D016232:Endothelins; D014667:Vasopressins; D000804:Angiotensin II; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D015740:Calcitonin Gene-Related Peptide