Aldosterone-stimulated PKC signalling cascades: from receptor to effector.
Aldosterone plays an important role in the regulation of blood pressure. The effects of this hormone have classically been described in terms of the transcriptional regulation of genes that facilitate electrolyte transport, particularly across high-resistance epithelia. The protein kinase signalling cascades that are rapidly activated in response to aldosterone are emerging as important modulators of the transcriptional response, and may serve to prime cells for the subsequent transcriptional changes. The activation of protein kinase D through an epidermal growth factor receptor transactivation pathway by aldosterone in renal cells has the potential to impact on cell trafficking events that regulate transporter activity.
Thomas
W
W
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ie
McEneaney
V
V
Harvey
B J
BJ
D000450:Aldosterone / Q000502:physiology*; D066246:ErbB Receptors / Q000235:genetics; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
D000450:Aldosterone; D066246:ErbB Receptors; D011493:Protein Kinase C