title: Effects of acute hippocampal stimulation on EEG dynamics.
abstract: Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus.
authors.affiliation: Dept. of Biomed. Eng., Florida Univ., Gainesville, FL 32611-6131, USA. spnair@ufl.edu
authors.forename: Sandeep P
authors.initials: SP
authors.lastname: Nair
authors.forename: J Chris
authors.initials: JC
authors.lastname: Sackellares
authors.forename: Deng-Shan
authors.initials: DS
authors.lastname: Shiau
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Norman
authors.forename: Linda K
authors.initials: LK
authors.lastname: Dance
authors.forename: Panos M
authors.initials: PM
authors.lastname: Pardalos
authors.forename: Jose C
authors.initials: JC
authors.lastname: Principe
authors.forename: Paul R
authors.initials: PR
authors.lastname: Carney
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000628:therapy*; D004867:Equipment Design; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D051381:Rats; D012640:Seizures; D013702:Temporal Lobe / Q000473:pathology*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants