title: Transcolonic ventral wall hernia mesh fixation in a porcine model.
abstract: OBJECTIVE
  A natural orifice transluminal endoscopic surgery (NOTES) approach to ventral wall hernia repair may represent a potentially less invasive alternative to current transabdominal surgical techniques. We aimed to investigate the feasibility of using transcolonic NOTES to deliver hernia repair mesh into the peritoneal cavity, as well as the ability to manipulate composite mesh and secure it to the abdominal wall.
  
  
  METHODS
  Five pigs weighing 20 to 25 kg were used in this feasibility study involving two acute and three survival experiments. A prototype mesh delivery system was used to transfer 1.5 - 2-cm x 2.5 - 3-cm pieces of composite hernia mesh into the peritoneal cavity. Neodymium magnets on a prototype control arm were used to help position the mesh by magnetically engaging previously placed endoscopic clips. Transfascial fixation of the mesh with 3-0 monofilament sutures was achieved using a 19-gauge hollow needle, pusher wire, and a suture tag system.
  
  
  RESULTS
  Composite hernia mesh was successfully transferred and secured in 5/5 attempts. All three survival animals thrived for 14 days prior to elective sacrifice. At necropsy, the mesh sites were found to be well peritonealized without adhesions. Suture placement through the posterior fascia was confirmed in 10/12 sutures. Of these, four sutures were within the abdominal musculature, and two sutures were through the anterior fascia (transfascial).
  
  
  CONCLUSIONS
  Transcolonic delivery, transcutaneous magnetic manipulation, and fixation of composite hernia mesh are technically feasible in a porcine model with animal survival. An effective suturing method that allows consistent anchoring through the anterior fascia would be preferred and may require the development of novel devices.
authors.affiliation: Division of Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Fong
authors.forename: M
authors.initials: M
authors.lastname: Ryou
authors.forename: R D
authors.initials: RD
authors.lastname: Pai
authors.forename: A
authors.initials: A
authors.lastname: Tavakkolizadeh
authors.forename: D W
authors.initials: DW
authors.lastname: Rattner
authors.forename: C C
authors.initials: CC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D003106:Colon; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D004195:Disease Models, Animal; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000601:surgery*; D019919:Prosthesis Implantation / Q000295:instrumentation*; D013526:Surgical Mesh; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine; D016896:Treatment Outcome