title: Lactate metabolism in anoxic turtles: an integrative review.
abstract: Painted turtles can accumulate lactic acid to extremely high concentrations during long-term anoxic submergence, with plasma lactate exceeding 200 mmol l(-1). The aims of this review are twofold: (1) To summarize aspects of lactate metabolism in anoxic turtles that have not been reviewed previously and (2) To identify gaps in our knowledge of turtle lactate metabolism by comparing it with lactate metabolism during and after exercise in other vertebrates. The topics reviewed include analyses of lactate's fate during recovery, the effects of temperature on lactate accumulation and clearance, the interaction of activity and recovery metabolism, fuel utilization during recovery, stress hormone responses during and following anoxia, and cellular lactate transport mechanisms. An analysis of lactate metabolism in anoxic turtles in the context of the 'lactate shuttle' hypothesis is also presented.
authors.affiliation: Department of Anesthesia, University of California, San Francisco, San Francisco, CA 94117, USA. warrend@anesthesia.ucsf.edu
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Warren
authors.forename: Donald C
authors.initials: DC
authors.lastname: Jackson
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D000860:Hypoxia / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D014426:Turtles / Q000378:metabolism*
chemical_list: D019344:Lactic Acid