title: Squamous cell carcinoma of the nasal columella: a retrospective study of 66 cases from the GETTEC.
abstract: Squamous cell carcinoma of the nasal columella (SCCNC) is a rare disease. We aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. Medical records of 66 patients presenting with columella squamous cell carcinoma in nine French hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. Mean age was 69 years. The sex ratio was one female for three males. Majority of the lesions were T1 N0 according to the classification international union against cancer. Patients underwent one of the three treatments: surgery alone for the T1 lesions, radiotherapy for tumors of T2-T3 and combined (surgery and radiotherapy) for T4 lesions. The 5-year Kaplan-Meier survival test was 39% and no difference was found between the therapeutic groups. Thirty-five (53%) tumor recurrences were observed with a median time of 43 months. As regards TNM classification and treatment, no significant difference between the two groups disease free/recurrence was found. Prognosis of early lesions was considered better than the advanced lesions. SCCNC is difficult to manage and has a poor prognosis. No therapeutic solution has yet been confirmed in the treatment of this pathology.
authors.affiliation: ENT Department, Rouen University Hospital, 1, rue de Germont, 76031, Rouen, France. olivier.choussy@chu-rouen.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Choussy
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Babin
authors.forename: Stéphane
authors.initials: S
authors.lastname: Temam
authors.forename: Alain
authors.initials: A
authors.lastname: Cosmidis
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Vedrine
authors.forename: Dominique
authors.initials: D
authors.lastname: De Raucourt
authors.forename: Jérôme
authors.initials: J
authors.lastname: Sarini
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bessede
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Lienhardt
authors.forename: Danièle
authors.initials: D
authors.lastname: Dehesdin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy