title: [Hepatic perfusion changes after interventional disconnection evaluated by CT perfusion imaging].
abstract: OBJECTIVE
  To evaluate the changes in hepatic perfusion after interventional obliteration in patients with cirrhosis and portal hypertension by means of spiral CT perfusion imaging.
  
  
  METHODS
  Twenty-three patients who suffered from cirrhosis and portal hypertension were selected to undergo interventional disconnection. Partial spleen embolization (PSE) was performed in 15 patients and PSE combined with percutaneous transhepatic obliteration (PTO) was carried out in 8 patients. Hepatic perfusion was carried out pre- and post-operation. The density-time curve was obtained from the interest region of liver, abdominal artery, portal vein. The parameters of perfusion were calculated by the means of deconvolution simultaneously.
  
  
  RESULTS
  The portal vein perfusion (PVP) decreased in patients with PSE, but total hepatic blood perfusion was not statistically different from that of pre-operation. After treatment, the hepatic artery perfusion increased obviously. PVP decreased from 0.862 to 0.722 ml x min(-1) x ml(-1) but was not statistically different from that of pre-operation. Hepatic arterial perfusion and total hepatic blood perfusion increased from 0.128, 0.990 ml x min(-1)x ml(-1) pre-operatively to 0.290, 1.021 ml x min(-1) x ml(-1) postoperatively in patients with PSE combined with PTO.
  
  
  CONCLUSIONS
  Spiral CT perfusion could objectively reflect the hemodynamic change in hepatic parenchyma after the interventional vascular obliteration.
authors.affiliation: Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China.
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Huang
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Liang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic; D005260:Female; D006499:Hepatic Artery / Q000503:physiopathology; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D036542:Tomography, Spiral Computed