P2X(7) receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators.
RONS (reactive oxygen and nitrogen species) have traditionally been perceived to be detrimental to the physiology of the cell, with reports citing mechanisms by which a range of proteins, lipids and DNA are damaged. Consequently, their action has been attributed to many pathologies and the aging process. Opposing these actions are the protective functions held by RONS, as highlighted in microbial destruction, and their role as important cellular signalling molecules. The present paper will focus on the newly emerging field of P2X(7)R (P2X(7) receptor)-induced RONS generation and the current understanding of the signalling pathways from receptor to RONS generators.
Hewinson
J
J
Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
Mackenzie
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AB
D000818:Animals; D006801:Humans; D051379:Mice; D009584:Nitrogen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D058486:Receptors, Purinergic P2X7; D015398:Signal Transduction
C546468:P2RX7 protein, human; C546469:P2rx7 protein, mouse; D017382:Reactive Oxygen Species; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D009584:Nitrogen