title: New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.
abstract: A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB(2) affinity and CB(2) versus CB(1) selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy. manera@farm.unipi.it
authors.forename: Clementina
authors.initials: C
authors.lastname: Manera
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Cascio
authors.forename: Veronica
authors.initials: V
authors.lastname: Benetti
authors.forename: Marco
authors.initials: M
authors.lastname: Allarà
authors.forename: Tiziano
authors.initials: T
authors.lastname: Tuccinardi
authors.forename: Adriano
authors.initials: A
authors.lastname: Martinelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saccomanni
authors.forename: Elisa
authors.initials: E
authors.lastname: Vivoli
authors.forename: Carla
authors.initials: C
authors.lastname: Ghelardini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Ferrarini
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D051379:Mice; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology
chemical_list: D009287:Naphthyridines; D011804:Quinolines; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2