Use of combination therapy in migraine: a review of the clinical evidence.
The previous article in this supplement sets forth a compelling argument for use of multimechanism combination pharmacotherapy as a strategy to improve outcomes for patients with migraine. This article picks up where the previous one left off by providing a concise review of data regarding use of combined agents to treat migraine. Included in this review are clinical studies of both over-the-counter (OTC) and prescription agents whose performance in combination has been assessed in comparison to placebo and/or monotherapy. Also, this review is not limited to fixed drug combinations; studies that used different single-agent tablets administered together are also included.
Taylor
Frederick
F
Smith
Timothy
T
D000700:Analgesics / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004338:Drug Combinations; D011307:Drug Prescriptions; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D004366:Nonprescription Drugs / Q000627:therapeutic use; D016896:Treatment Outcome; D014363:Tryptamines / Q000627:therapeutic use*
D000700:Analgesics; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; D004366:Nonprescription Drugs; D014363:Tryptamines