Effect of a high-intensity exercise training on the metabolism and function of macrophages and lymphocytes of walker 256 tumor bearing rats.
Epidemiologic studies suggest that moderately intense training promotes augmented immune function, whereas strenuous exercise can cause immunosupression. Because the combat of cancer requires high immune function, high-intensity exercise could negatively affect the host organism; however, despite the epidemiologic data, there is a lack of experimental evidence to show that high-intensity training is harmful to the immune system. Therefore, we tested the influence of high-intensity treadmill training (10 weeks, 5 days/week, 30 mins/day, 85% VO(2)max) on immune system function and tumor development in Walker 256 tumor-bearing Wistar rats. The metabolism of glucose and glutamine in lymphocytes and macrophages was assessed, in addition to some functional parameters such as hydrogen peroxide production, phagocytosis, and lymphocyte proliferative responses. The metabolism of Walker 256 cells was also investigated. Results demonstrated that high-intensity training increased the life span of tumor-bearing rats, promoted a reduction in tumor mass, and prevented indicators of cachexia. Several changes, such as a reduction in body weight and food intake and activation of glutamine metabolism in macrophages and lymphocytes induced by the presence of Walker 256 tumor, were prevented by high intensity training. The reduction in tumor growth was associated with an impairment of tumor cell glucose and glutamine metabolism. These data suggest that high-intensity exercise training may be a viable strategy against tumors.
Bacurau
Aline Villa Nova
AV
School of Physcial Education and Sport, University of Sao Paulo, SP, Brazil. reurybacurau@uol.com.br
Belmonte
Mônica Aparecida
MA
Navarro
Francisco
F
Moraes
Milton Rocha
MR
Pontes
Francisco Luciano
FL
Pesquero
Jorge Luiz
JL
Araújo
Ronaldo Carvalho
RC
Bacurau
Reury Frank Pereira
RF
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism / Q000503:physiopathology*; D002149:Energy Intake; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D008017:Life Expectancy; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D008297:Male; D010101:Oxygen Consumption; D010587:Phagocytosis; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
D005973:Glutamine; D005947:Glucose