Two new cytotoxic quinone type compounds from the halotolerant fungus Aspergillus variecolor.
Two new quinone type compounds, variecolorquinones A (1) and B (2) together with eleven known related compounds 3 approximately 13 have been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structures of 1 and 2 were determined by spectroscopic methods. 1 exhibited selective cytotoxicity against A-549 cells with the IC50 values of 3.0 microM. 2 showed cytotoxicity against HL60 and P388 cells with the IC50 values of 1.3 and 3.7 microM, respectively.
Wang
Wenliang
W
Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China.
Zhu
Tianjiao
T
Tao
Hongwen
H
Lu
Zhenyu
Z
Fang
Yuchun
Y
Gu
Qianqun
Q
Zhu
Weiming
W
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry* / Q000235:genetics; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000903:Antibiotics, Antineoplastic; D011809:Quinones; C525996:variecolorquinone A; C525995:variecolorquinone B