Correlation of CD4 counts and CD4/CD8 ratio with HIV-infection associated oral manifestations.
BACKGROUND
The relationship between oral lesions arising from HIV infection and CD4/CD8 cell ratios is of relevance in clinical assessment of immune suppression.


OBJECTIVE
To correlate the prevalence of oral manifestations arising from HIV infection and the levels of CD4/CD8 cell ratios.


METHODS
A cross-sectional study.


METHODS
Kenyatta National Hospital, Nairobi, Kenya.


METHODS
Two hundred and seven HIV-infected patients in medical wards were recruited in the study.


RESULTS
Seventy eight (37.7%) were male and 129 (62.3%) female, with an age range of 18-73 years (mean=34.81 years). Oral manifestations encountered with highest prevalence in the oral cavity included: hyperplastic candidosis (labial mucosa) 15%, erythematous candidosis (gingival) 5%, angular cheilitis 32.4%, herpes simplex (corner of the mouth) 0.5%, persistent oral ulceration (labial mucosa) 0.5%, Parotid enlargement 2% and Kaposis sarcoma (hard/soft palate) 2.9%.


CONCLUSIONS
The prevalence of oral manifestations was higher with low CD4 count <200 cell/mm3 and mean CD4/CD8<0.39(95%CI 0.32-0.48).
Butt
F M A
FM
Department of Oral and Maxillofacial Surgery, College of Health Sciences, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.
Vaghela
V P
VP
Chindia
M L
ML
D000293:Adolescent; D000328:Adult; D000368:Aged; D015704:CD4 Antigens; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens; D002177:Candidiasis; D002613:Cheilitis; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012514:Sarcoma, Kaposi; D012737:Sex Factors
D015704:CD4 Antigens; D016827:CD8 Antigens