title: Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents.
abstract: The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.
authors.affiliation: Instituto de Pesquisas Clínica Evandro Chagas-IPEC, Av. Brasil, 4365 Manguinhos Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Silva Lourenço
authors.forename: Felipe
authors.initials: F
authors.lastname: Rodrigues Vicente
authors.forename: Maria das Graças Muller
authors.initials: Md
authors.lastname: de Oliveira Henriques
authors.forename: André Luis
authors.initials: AL
authors.lastname: Peixoto Candéa
authors.forename: Raoni Schroeder
authors.initials: RS
authors.lastname: Borges Gonçalves
authors.forename: Thais Cristina M
authors.initials: TC
authors.lastname: Nogueira
authors.forename: Marcelle
authors.initials: M
authors.lastname: de Lima Ferreira
authors.forename: Marcus Vinícius
authors.initials: MV
authors.lastname: Nora de Souza
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D013876:Thiophenes