Differences in pHi recovery in CO2-chemosensitive and non-chemosensitive cells: predictions from a mathematical model.
In this paper, we present a mathematic model designed to identify potential mechanisms responsible for the observed differences in pHi recovery in CO(2)-chemosensitive versus non-chemosensitive cells. The model suggests that differences in pHi regulation may be dependent upon differences in the activation set-point of the internal modifier site of the Na(+)/H(+) exchanger (NHE).
Cordovez
Juan M
JM
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 USA. jcordove@ic.sunysb.edu
Clausen
Chris
C
Moore
Leon C
LC
Solomon
Irene C
IC
D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical
D002245:Carbon Dioxide