title: Inhibition of SARS coronavirus helicase by bismuth complexes.
abstract: A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Julian A
authors.initials: JA
authors.lastname: Tanner
authors.forename: Zai
authors.initials: Z
authors.lastname: Wang
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
authors.forename: Bo-Jian
authors.initials: BJ
authors.lastname: Zheng
authors.forename: Nianyong
authors.initials: N
authors.lastname: Zhu
authors.forename: Hongzhe
authors.initials: H
authors.lastname: Sun
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001729:Bismuth / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004265:DNA Helicases / Q000037:antagonists & inhibitors*; D004121:Dimethyl Sulfoxide; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000201:enzymology*; D015032:Zinc / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D011166:Porphyrins; D000251:Adenosine Triphosphatases; D004265:DNA Helicases; D015032:Zinc; D001729:Bismuth; D004121:Dimethyl Sulfoxide