title: Aortic intima-media thickness, serum IGF-I, IGFBP-3, and leptin levels in intrauterine growth-restricted newborns of healthy mothers.
abstract: Neonates with intrauterine growth restriction (IUGR) are associated with reduced concentrations of IGF-I that might contribute to arterial wall thickening. Direct atherogenic effects of leptin have been described. We aimed to investigate the relationship among abdominal aortic intima-media thickness (aIMT), serum IGF-I, IGF binding protein-3, and leptin levels in neonates with IUGR. Abdominal aIMT was measured in 40 term neonates with IUGR and in 40 controls. Mean aIMT was significantly greater in neonates with IUGR (0.45 +/- 0.03 mm) than in controls (0.39 +/- 0.04 mm, p < 0.0001). Serum IGF-I and leptin levels were lower in neonates with IUGR than in controls. There was a significant positive correlation between aIMT and gestational age, whereas a significant negative correlation was determined between aIMT and IGF-I in the IUGR neonates. For aIMT, significant associations included serum IGF-I level (beta = -0.406, p = 0.006) and gestational age (beta = 0.331, p = 0.022) in a multiple stepwise linear regression analysis. In control neonates, serum IGF-I levels were negatively related to aIMT (beta = -0.750, p < 0.001). Neonates with IUGR have significant aIMT with decreased IGF-I. IGF-I levels determine aIMT not only in neonates with IUGR but also in healthy controls.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, 38039, Turkey. esad@erciyes.edu.tr
authors.forename: Esad
authors.initials: E
authors.lastname: Koklu
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Ozturk
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakus
authors.forename: Ali
authors.initials: A
authors.lastname: Yikilmaz
authors.forename: Tamer
authors.initials: T
authors.lastname: Gunes
mesh_terms: D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology*; D001724:Birth Weight; D001827:Body Height; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D018616:Ultrasonography, Doppler, Duplex
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D020738:Leptin; D007334:Insulin-Like Growth Factor I