Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents.
Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings.
Pérez-Mayoral
Elena
E
Laboratorio de Síntesis Orgánica e Imagen Molecular por Resonancia Magnética, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain.
Soler-Padrós
Jordi
J
Negri
Viviana
V
Cerdán
Sebastián
S
Ballesteros
Paloma
P
D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D003287:Contrast Media; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; D005682:Gadolinium