Cardioprotective effect of ocotillol, a derivate of pseudoginsenoside F11, on myocardial injury induced by isoproterenol in rats.
OBJECTIVE
To investigate whether ocotillol, a derivate of pseudoginsenoside F11, might protect the heart against myocardial injury (MI) induced by isoproterenol (CAS 7683-59-2, ISO) in rats.


METHODS
Male Sprague-Dawley rats were administered orally (5, 10 and 20 mg kg(-1)) for 8 days. During the last two days all animals except the normal control were administered ISO, 50 mg kg(-1) subcutaneously, for 2 consecutive days to induce myocardial injury. 8 h later, rats were anaesthetized and sacrificed. The biochemical parameters were assayed and pathological examination of the heart tissues was performed.


RESULTS
Ocotillol could significantly decrease the increased level of lactate dehydrogenase (LDH) in animals with myocardial injury induced by ISO. In the heart of ISO injected rats the superoxide dismutase (SOD) was decreased but the contents of malondialdehyde (MDA) were increased. Pre-treatment with ocotillol could attenuate the changes of both SOD and MDA. The ISO-induced pathohistological changes were also ameliorated by ocotillo.


CONCLUSIONS
The findings suggested that ocotillol could have cardioprotective effects on myocardial injury induced by ISO in rats, which may be, in part, by virtue of enhancing the antioxidative potency of the heart.
Yu
Chen
C
Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, The People's Republic of China.
Fu
Fenghua
F
Yu
Xin
X
Han
Bing
B
Zhu
Mei
M
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000517:prevention & control*; D002316:Cardiotonic Agents; D036145:Ginsenosides / Q000737:chemistry* / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007545:Isoproterenol / Q000008:administration & dosage; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D000975:Antioxidants; D015415:Biomarkers; D002316:Cardiotonic Agents; D036145:Ginsenosides; C524540:ocotillol; C413985:pseudoginsenoside F11; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D007545:Isoproterenol