title: HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia.
abstract: Severe bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen-E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens.
authors.affiliation: Immunology and Histocompatibility Department, CIB-HOG, AP-HP/GHU-Nord, IUh and INSERM U662, Saint-Louis Hospital, Paris, France. tamouza@histo.chu-stlouis.fr
authors.forename: Ryad
authors.initials: R
authors.lastname: Tamouza
authors.forename: Marc
authors.initials: M
authors.lastname: Busson
authors.forename: Catherine
authors.initials: C
authors.lastname: Fortier
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Diagne
authors.forename: Dapa
authors.initials: D
authors.lastname: Diallo
authors.forename: Ivan
authors.initials: I
authors.lastname: Sloma
authors.forename: Hector
authors.initials: H
authors.lastname: Contouris
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: Dominique
authors.initials: D
authors.lastname: Labie
authors.forename: Robert
authors.initials: R
authors.lastname: Girot
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
mesh_terms: D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology*; D001424:Bacterial Infections / Q000453:epidemiology / Q000235:genetics*; D044383:Black People; D015897:Comorbidity; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D006720:Homozygote; D006801:Humans; D008297:Male; D008302:Mali / Q000453:epidemiology; D010297:Paris / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D000097625:HLA-E Antigens
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens