Combining capillary with radio-frequency-only quadrupole as an interface for a home-made time-of-flight mass spectrometer.
A heated capillary tube combined with a radio-frequency-only quadrupole has been coupled with a home- made, high-resolution orthogonal-injection, time-of-flight mass spectrometer to improve ion transmission from the atmospheric pressure to the low--pressure regions. With an electrospray ion source, the performance of the interface on the intensity of spectra was investigated. For electrospray ionization, the ion intensity detected on the time-of- flight mass spectrometer was seen to increase three-fold compared with an orifice interface. It has been shown that the enhanced ion inlet designs can not only increase the ion translation efficiency, but also improve the detection limits of the mass spectrometer. Coupling atmospheric pressure matrix-assisted laser desorption/ionization with the improved interface resulted in an instrument detection limit as low as 2.5 fmol.
Guo
Changjuan
C
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China. cjguo@gig.ac.cn
Huang
Zhengxu
Z
Gao
Wei
W
Nian
Huiqing
H
Zhou
Zhen
Z
Chen
Huayong
H
Fu
Jiamu
J
D001274:Atmospheric Pressure; D006358:Hot Temperature; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation*