title: Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills.
abstract: BACKGROUND
  Vulvar vestibulitis syndrome (VVS) is a diverse, multifactorial phenomenon. Its precise etiology is unknown.
  
  
  OBJECTIVE
  To define the association between oral contraceptive (OC) estrogen dosage and VVS. Methods. Women diagnosed as having VVS participated in the study.
  
  
  METHODS
  Data on type and usage of oral contraceptive pills (OC) were obtained by a questionnaire, and they were compared for the data on OC usage in the general population.
  
  
  RESULTS
  Available commercial data on Israeli women taking OC showed that 51% of them use low-dose estrogen (</=20 microg) OC and 49% use higher-dose estrogen (30-35 microg) OC. Of the 132 women in the study, 86 (65%) used OC: 68 (79%) used low-dose estrogen OC (P < 0.002 compared to the general population), while only 18 (21%) used high-dose estrogen OC (P < 0.002 compared to the general population).
  
  
  CONCLUSIONS
  Significantly more patients who are treated in our clinic for VVS use low-dose estrogen than those who use high-dose estrogen OC.
authors.affiliation: Tel Aviv Sourasky Medical Center - Urology, Tel-Aviv, Israel. surge04@post.tau.ac.il
authors.forename: Alexander
authors.initials: A
authors.lastname: Greenstein
authors.forename: Zahi
authors.initials: Z
authors.lastname: Ben-Aroya
authors.forename: Orit
authors.initials: O
authors.lastname: Fass
authors.forename: Idan
authors.initials: I
authors.lastname: Militscher
authors.forename: Yelena
authors.initials: Y
authors.lastname: Roslik
authors.forename: Juza
authors.initials: J
authors.lastname: Chen
authors.forename: Liora
authors.initials: L
authors.lastname: Abramov
mesh_terms: D000328:Adult; D003268:Contraception Behavior / Q000706:statistics & numerical data; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D054515:Vulvar Vestibulitis / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology*; D016387:Women's Health
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens