title: CSF proteomic fingerprints for HIV-associated cognitive impairment.
abstract: Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.
authors.affiliation: Specialized Neurosciences Research Program, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
authors.forename: Juliana Pérez
authors.initials: JP
authors.lastname: Laspiur
authors.forename: Eric R
authors.initials: ER
authors.lastname: Anderson
authors.forename: Pawel
authors.initials: P
authors.lastname: Ciborowski
authors.forename: Valerie
authors.initials: V
authors.lastname: Wojna
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rozek
authors.forename: Fenghai
authors.initials: F
authors.lastname: Duan
authors.forename: Raul
authors.initials: R
authors.lastname: Mayo
authors.forename: Elaine
authors.initials: E
authors.lastname: Rodríguez
authors.forename: Marinés
authors.initials: M
authors.lastname: Plaud-Valentín
authors.forename: José
authors.initials: J
authors.lastname: Rodríguez-Orengo
authors.forename: Howard E
authors.initials: HE
authors.lastname: Gendelman
authors.forename: Loyda M
authors.initials: LM
authors.lastname: Meléndez
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000378:metabolism* / Q000821:virology*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology*; D015331:Cohort Studies; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D008969:Molecular Sequence Data; D009483:Neuropsychological Tests; D040901:Proteomics; D019562:Viral Load / Q000379:methods