title: Alpha-fetoprotein-producing early gastric cancer of the remnant stomach: report of a case.
abstract: A 67-year-old man initially underwent a distal gastrectomy for early gastric cancer (T1, N0, M0; Stage IA) in March 1995. During the follow-up period, an elevation of the serum alpha-fetoprotein (AFP) level (98.8 ng/ml) and a liver tumor (S4) were detected. A left hepatectomy was performed in December 1996. Immunohistochemically, AFP-positive cells were present in both the primary gastric tumor and metastasized liver tumor. The serum AFP level normalized immediately, but it elevated again to 22.4 ng/ml. An endoscopic examination revealed a protruding lesion in the remnant stomach. A total resection of the remnant stomach was performed in February 2005. The tumor was evaluated T1, N0, M0; Stage IA, with positive staining for AFP. The patient has survived without any sign of recurrence for more than 11 years after the first diagnosis of cancer. To the best of our knowledge, this is the first case of a long-term survival of AFP-producing gastric cancer with successfully resected metachronous liver metastasis and gastric remnant carcinoma.
authors.affiliation: Department of Surgery, Kotou General Hospital, 37 Kawasaki, Hachirogata-machi, Minamiakita-gun, Akita 018-1605, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shibata
authors.forename: Kouhei
authors.initials: K
authors.lastname: Sato
authors.forename: Masashi
authors.initials: M
authors.lastname: Kodama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nanjyo
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000556:secondary; D000368:Aged; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins