Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides.
Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation.
Gangadhar
Vidya
V
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Jeyakani
Justin J
JJ
Shaila
M S
MS
Nayak
Rabindranath
R
Chandra
Nagasuma
N
D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry* / Q000276:immunology; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000737:chemistry* / Q000276:immunology; D019295:Computational Biology; D000939:Epitopes; D005805:Genes, MHC Class I / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000737:chemistry; D007156:Immunologic Memory; D008958:Models, Molecular; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding
D000888:Antibodies, Anti-Idiotypic; D000956:Antigens, Viral; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D007135:Immunoglobulin Variable Region; D010455:Peptides