Ubiquitin signals in the NF-kappaB pathway.
The NF-kappaB (nuclear factor kappaB) transcription factors control cell survival, proliferation and innate and adaptive immune response. Post-translational modifications of key components of the NF-kappaB pathway provide the molecular basis for signal transmission from the cell membrane to the nucleus. Here, we describe the involvement of different types of ubiquitin modification in the regulation of the NF-kappaB signalling pathway.
Terzic
J
J
Department of Immunology, Split Medical School, University of Split, Soltanska 2, 21000 Split, Croatia.
Marinovic-Terzic
I
I
Ikeda
F
F
Dikic
I
I
D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*
D016328:NF-kappa B; D025801:Ubiquitin