title: Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells.
abstract: Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.
authors.affiliation: Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Isada
authors.forename: Munetaka
authors.initials: M
authors.lastname: Hirose
authors.forename: Eri
authors.initials: E
authors.lastname: Murata
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okayama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Takatori
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tani
authors.forename: Keita
authors.initials: K
authors.lastname: Fukazawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Shigemi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000399:Air Pressure; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000032:analysis / Q000378:metabolism; D020932:Nerve Growth Factor / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D016716:PC12 Cells; D010766:Phosphorylation; D051381:Rats; D020917:Receptor, trkA / Q000378:metabolism
chemical_list: D020932:Nerve Growth Factor; D020917:Receptor, trkA; D048049:Extracellular Signal-Regulated MAP Kinases