Discovery of recurrent multiple brain states in non-convulsive status epilepticus.
OBJECTIVE
We study burst-like patterns of epileptiform discharges in non-convulsive status epilepticus (SE).


METHODS
Epileptiform burst-like transients were identified by estimating the amplitude envelope of the EEG signal, and recurrence and similarities were identified by pairwise matching in the time-domain.


RESULTS
We identified similarities in the onset of a significant fraction of the epileptiform bursts, and a bimodal distribution of the burst durations.


CONCLUSIONS
Bursts of epileptiform discharges during a non-convulsive SE are manifestations of multiple patterns of recurring brain states.


CONCLUSIONS
Quantitative description of ictal phenomena in epilepsy and status epilepticus adds to the knowledge of abnormal brain behavior and may assist in improved patient care.
van Putten
Michel J A M
MJ
Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, 7500 KA, Enschede, The Netherlands. m.vanputten@mailcss.com
van Putten
Maurice H P M
MH
D000465:Algorithms; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000503:physiopathology; D004568:Electrodiagnosis / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D011237:Predictive Value of Tests; D012815:Signal Processing, Computer-Assisted; D013226:Status Epilepticus / Q000175:diagnosis* / Q000503:physiopathology*