[Effect of granulocyte colony-stimulating factor on immunological regulation and its application in allogenic hematopoietic stem cell transplantation].
The granulocyte colony-stimulating factor (G-CSF) plays an important role in regulating function of immunocytes in process of mobilizing hematopoietic stem cells. The deep understanding of the immunoregulatory effects of G-CSF has important significance to improve the outcomes of patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation, included alleviating acute graft-versus-host disease, maintaining or enhancing graft-versus-leukemia effects and decreasing the relapse rates. In this article, the immunoregulatory effect of G-CSF on graft of peripheral blood and bone marrow, the immunoregulation of G-CSF and allo-hematopoietic stem cell transplantation, as well as the prospective trend of research on immunoregulatory effects of G-CSF were reviewed.
Chang
Ying-Jun
YJ
Institute of Hematology and People Hospital, Peking University, Beijing 100044, China.
Zhao
Xiang-Yu
XY
Huang
Xiao-Jun
XJ
D000818:Animals; D006086:Graft vs Host Disease / Q000517:prevention & control*; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans
D016179:Granulocyte Colony-Stimulating Factor