Stress echocardiography for risk stratification of asymptomatic patients with type 2 diabetes mellitus.
BACKGROUND
The purpose of this study was to assess stressechocardiography (SE) for risk stratification of asymptomatic type 2 diabetic patients (DM2) without known coronary artery disease CAD.


METHODS
A total of 211 consecutive, asymptomatic DM2 patients underwent exercise (n=177) or dobutamine (n=34) SE and were followed up for 11+/-2 months. Primary endpoint was a major cardiac or vascular event (MACCE; all-cause-death, non-fatal myocardial infarction, coronary revascularization procedures, cerebrovascular event, acute limb-ischemia).


RESULTS
During follow-up 39 of these patients suffered a MACCE. SE correctly identified 33 of these 39 patients by demonstrating silent ischemia in advance. In a multivariate logistic regression analysis a positive SE turned out to be an independent predictor for the occurrence of a MACCE during 11+/-2 months.


CONCLUSIONS
SE represents an effective tool for risk stratification of asymptomatic DM2 patients.
Fateh-Moghadam
Suzanne
S
Medizinische Klinik mit Schwerpunkt Kardiologie, Universitätsklinik Charité-Campus Virchow, Humboldt-Universität zu Berlin und Freie Universität Berlin, Germany. suzanne.fateh-moghadam@charite.de
Reuter
Thomas
T
Htun
Patrik
P
Plöckinger
Ursula
U
Dietz
Rainer
R
Bocksch
Wolfgang
W
D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging*; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors