title: Morphological aspect of voice disturbances of aged persons coexisting hypopharynx cancer.
abstract: The voice quality in prebysphonia is conditioned by morphological changes in the vocal folds mucosa. The studies including light microscopy and transmission electron microscopy (TEM) revealed changes within the basal membrane epithelium and the stroma of the vocal folds mucosa. Age-related changes in thickness of the epithelium and direction of the basal membrane, increased number of collagenous fibres (C) and fibroblasts and chronic inflammatory process in the stroma were found. Vacuolated and keratinised epithelial cells, enlarged extracellular spaces and numerous blood vessels confirm the edematous form of prebysphonia. Thinned epithelium with signs of hyalinization, inflammatory infiltrations in the stroma with numerous collagenous fibres and small number of blood vessels indicate atrophy of the vocal folds mucosa. Edematous and atrophic changes in the vocal folds mucosa are most frequently reported form of prebysphonia.
authors.affiliation: Department of Otolaryngology, Medical University of Bialystok, Poland. otol@amb.edu.pl
authors.forename: Bozena
authors.initials: B
authors.lastname: Kosztyla-Hojna
authors.forename: Anna
authors.initials: A
authors.lastname: Andrzejewska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Rutkowski
authors.forename: Marek
authors.initials: M
authors.lastname: Rogowski
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000150:complications*; D007820:Laryngeal Mucosa / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D012015:Reference Standards; D014827:Vocal Cords / Q000473:pathology*; D014832:Voice Disorders / Q000150:complications / Q000473:pathology*