Serum mannose-binding lectin levels are linked with respiratory syncytial virus (RSV) disease.
The innate immune response facilitates the quality of the adaptive immune response and is critical to an individual's susceptibility to infection and disease. Mannose-binding lectin (MBL) is a plasma protein with anti-microbial properties that binds a wide range of pathogens to flag them for immune destruction independent of antibodies. In this study, serum MBL levels were measured in 81 children <5 years old experiencing acute respiratory syncytial virus infection and in 40 control children to determine the association with disease severity. Almost 70% of all RSV-infected children had low to intermediate MBL levels (<500 ng/ml) compared to controls, and most of the <6 months old RSV interned patients had low to intermediate levels. No differences were detected in MBL levels between case and control children <1 month old. Analysis of the T-cell compartment in peripheral blood mononuclear cells (PBMC) from acute RSV-infected and control children showed that the percent CD4+ T cells was statistically lower in RSV-infected children > or =6 months old compared to controls, while the percent CD8+ T cells in RSV-infected and control PBMC was generally similar. These results suggest that low serum MBL levels may be a marker of RSV disease severity in children and that MBL may be important in limiting RSV disease pathogenesis.
Ribeiro
Lucas Zimon Giacomini
LZ
Laboratório de Virologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia (UFU), Av. Pará, 1720, Bloco 4C, andar superior, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil.
Tripp
Ralph A
RA
Rossi
Lívia Maria Gonçalves
LM
Palma
Patrícia Vianna Bonini
PV
Yokosawa
Jonny
J
Mantese
Orlando Cesar
OC
Oliveira
Thelma Fátima Mattos
TF
Nepomuceno
Lysa Luiz
LL
Queiróz
Divina Aparecida Oliveira
DA
D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D017252:CD3 Complex / Q000032:analysis; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D019002:CD56 Antigen / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D002675:Child, Preschool; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000737:chemistry / Q000166:cytology; D007963:Leukocytes, Mononuclear / Q000166:cytology; D018655:Lymphocyte Count; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D018357:Respiratory Syncytial Virus Infections / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000166:cytology
D015415:Biomarkers; D017252:CD3 Complex; D019002:CD56 Antigen; D006681:HLA-D Antigens; D037601:Mannose-Binding Lectin