[Effect of bismuth glycyrrhizate on experimental gastric ulcers and its mechanisms].
OBJECTIVE
To investigate the ulcer-preventive effect of bismuth glycyrrhizate on experimental gastric ulcer and its mechanisms.


METHODS
Three kinds of model animals with experimental gastric ulcer were established and gastric mucosal injuries were induced by pyloric ligation in rats, applying ethanol in rats and imposing stress in mice, respectively. The rats were divided into experimental groups treated with bismuth glycyrrhizat 700, 350, 175 mg kg(-1), positive control group treated with cimetidine (200 mg kg(-1), and negative control group treated with 0.1% EDTA. The mice were divided into experimental groups treated with bismuth glycyrrhiza 980, 490, 250 mg kg(-1). The gastric ulcer index, gastric juice volume, acidity, pepsin activity, the level of nitric oxide (NO) in serum and the level of prostaglandin E2 in gastric tissue were measured in rats.


RESULTS
Bismuth glycyrrhizate was shown to be able to reduce the gastric juice volume, acidity and pepsin activity as well as gastric ulcer index. It could increase the content of NO in serum and the content of prostaglandin E2 in gastric tissue.


CONCLUSIONS
The bismuth glycyrrhizate has antiulcer effect in rats.
Ji
Xiao-ling
XL
Ningxia Medical College, Yinchuan 750004, China. jixl@nxmc.edu.cn
Jiang
Yuan-xu
YX
Ren
Bin-bin
BB
Liu
Kai
K
Liu
Gang
G
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001729:Bismuth / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000097:blood; D010434:Pepsin A / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology*
D000897:Anti-Ulcer Agents; D009569:Nitric Oxide; D019695:Glycyrrhizic Acid; D010434:Pepsin A; D015232:Dinoprostone; D001729:Bismuth