How to trace stem cells for MRI evaluation?
Applications of imaging techniques to visualize stem cells for monitoring, control and treatment of biological systems, in particular the brain, is at the forefront of investigations. These approaches involve the identification of stem and precursor cells that may be of various origins, but are related to specific clinical conditions, and the choice of the appropriate markers to achieve the required imaging while minimizing the side effects. This article will review examples of the contrast agent design for rational approaches in stem cell imaging. Potential pitfalls or side effects associated with contrast agents, in particular iron oxide nanoparticles, for cell labelling are also discussed.
Dousset
Vincent
V
Laboratoire de Neurobiologie des Affections de la Myéline EA 2966 Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat 33076 Bordeaux, France. vincent.dousset@chu-bordeaux.fr
Tourdias
Thomas
T
Brochet
Bruno
B
Boiziau
Claudine
C
Petry
Klaus G
KG
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D003287:Contrast Media / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000502:physiology*
D003287:Contrast Media