title: Infection with Scedosporium apiospermum and S. prolificans, Australia.
abstract: Scedosporium apiospermum and S. prolificans are fungi of increasing clinical importance, particularly in persons with underlying diseases. We reviewed the records of 59 patients in Australia from whom Scedosporium spp. were isolated from June 30, 1997, through December 31, 2003. S. apiospermum was isolated predominantly from the respiratory tracts of 28 of 31 patients with underlying lung diseases and resulted in 2 infections and 1 death. The annual number of S. apiospermum isolates remained constant. S. prolificans was isolated from 28 patients only after November 1999. Eight patients with acute myeloid leukemia or hematopoietic stem cell transplants had invasive infection; 4 had fungemia and 6 died from infection. S. prolificans caused locally invasive infection in 2 immunocompetent patients and was found in the respiratory tract of 18 patients with underlying respiratory disease but did not cause fungemia or deaths in these patients. Scedosporium spp. showed distinct clinical and epidemiologic features.
authors.affiliation: Alfred Hospital, Prahran, Victoria, Australia.
authors.forename: Louise
authors.initials: L
authors.lastname: Cooley
authors.forename: Denis
authors.initials: D
authors.lastname: Spelman
authors.forename: Karin
authors.initials: K
authors.lastname: Thursky
authors.forename: Monica
authors.initials: M
authors.lastname: Slavin
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D012189:Retrospective Studies; D021681:Scedosporium / Q000187:drug effects / Q000302:isolation & purification*