title: Clinical outcomes in children with hyoscyamus niger intoxication not receiving physostigmine therapy.
abstract: OBJECTIVE
  Diagnosis of hyoscyamus niger intoxication is based on clinical symptomatology and history. Therapy includes stomach lavage, supportive therapy, and physostigmine as a specific antidote. Physostigmine is not available in Turkey. This retrospective study investigated the clinical outcomes in children with hyoscyamus niger intoxication who did not receive physostigmine therapy.
  
  
  METHODS
  Twenty-three children whose history and medical records indicated hyoscyamus niger intoxication were included the study.
  
  
  RESULTS
  None of the cases had any abnormal laboratory findings. All the patients were performed gastric lavage and provided with supportive therapy. None of the children had any complications, and none required mechanical ventilation or died. All the patients were discharged in good health within 48 h.
  
  
  CONCLUSIONS
  Our findings suggest that hyoscyamus niger intoxication in children is self-terminating and responds to supportive therapy and that routine use of physostigmine is unnecessary in every case with hyoscyamus niger intoxication.
authors.affiliation: Department of Pediatrics, Ataturk University, Faculty of Medicine, Erzurum, Turkey. hdoneray@hotmail.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Doneray
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Orbak
authors.forename: Cahit
authors.initials: C
authors.lastname: Karakelleoglu
mesh_terms: D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D002606:Charcoal / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D005260:Female; D005751:Gastric Lavage; D006785:Hospitals, University; D006801:Humans; D032304:Hyoscyamus / Q000506:poisoning*; D008297:Male; D010830:Physostigmine / Q000627:therapeutic use; D010939:Plant Poisoning / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011595:Psychomotor Agitation / Q000209:etiology; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D012965:Sodium Chloride / Q000008:administration & dosage; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000931:Antidotes; D002800:Cholinesterase Inhibitors; D002606:Charcoal; D012965:Sodium Chloride; D010830:Physostigmine