title: Development of a finger joint phantom for evaluation of frequency domain measurement systems.
abstract: For development and test of new optical imaging devices, phantoms are widely used to emulate the tissue to be imaged. Phantom design gets more difficult the more complex the tissue is structured. We report on developing and testing a solid, stable finger joint phantom to simulate transillumination of finger joints in frequency-domain imaging systems. The phantom consists of the bone, capsule, skin, the capsule volume, and the joint gap. Silicone was used to build the solid parts and a glycerol-water solution for the fluid in the capsule volume and joint gap. The system to test the phantom is an optical frequency-domain scanning set-up. Different stages of joint inflammation as they occur in rheumatoid arthritis (BA) were emulated by assembling the phantom with capsule and fluid having different optical properties. Reliability of the phantom measurement was investigated by repeated assembling. The results show clear discrimination between different stages of joints within the signal deviation due to reassembling of the phantom.
authors.affiliation: Inst. fur Medizinische Phys. & Lasermedizin, Charite-Universitatsmedizin Berlin. uwe.netz@charite.de
authors.forename: Uwe J
authors.initials: UJ
authors.lastname: Netz
authors.forename: Alexander K
authors.initials: AK
authors.lastname: Scheel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Beuthan
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005384:Finger Joint / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D014054:Tomography / Q000295:instrumentation* / Q000379:methods