[Iodine metabolism and pathologic processes in the thyroid gland under radioiodine lesions in the regions of goitrous endemia].
An existing discrepancy between the prognostic estimations and real thyroid gland sickness rate due to radiation exposure from Chernobyl is an evidence of inaccuracy of radiation doses determination. The estimation of the thyroid cancer risks is based on the assumption that the absorbed dose is uniformly distributed in the organ. But functional asynchronicity specific for iodine metabolism in thyroid may modify a space distribution of the dose. The biochemical features of the contaminated areas including iodine deficit and goitrous endemia usually are not taken into account may influence the second phase of thyroid carcinogenesis that is the promotion due to increased accumulation of some carcinogenic microelements in goitrous thyroid. In the work we consider these problems which can make significant changes in radiation risks estimation.
Malenchenko
A F
AF
Vasilenko
I Ia
IIa
Vasilenko
O I
OI
D000818:Animals; D047852:Chernobyl Nuclear Accident; D006043:Goiter, Endemic / Q000453:epidemiology; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000633:toxicity*; D011379:Prognosis; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013967:Thyroiditis, Autoimmune / Q000209:etiology*
D007457:Iodine Radioisotopes; D007455:Iodine