Regioselective synthesis of asymmetrically substituted 2-quinoxalinol salen ligands.
Diamino-2-quinoxalinols are reacted with salicylaldehyde derivatives to produce 2-quinoxalinol imines regioselectively as one isomer in good yield. Regioselectivity has been determined through the use of isotopic 15N labeling experiments. The 2-quinoxalinol imines may then be reacted without further purification with additional salicylaldehyde derivatives to yield asymmetrically substituted 2-quinoxalinol salens.
Wu
Xianghong
X
Department of Chemistry and Biochemistry, College of Science and Mathematics, Auburn University, Auburn, AL 36849-5319, USA.
Gorden
Anne E V
AE
Tonks
Stephen A
SA
Vilseck
Jonah Z
JZ
D020650:Combinatorial Chemistry Techniques; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D005029:Ethylenediamines; D007097:Imines; D008024:Ligands; D011810:Quinoxalines; C011452:disalicylaldehyde ethylenediamine