title: Positive mood and sleep disturbance in acquired mania following temporal lobe damage.
abstract: OBJECTIVE
  To determine the mood profile and sleep functioning of a patient with left anterior temporal region damage characterized by post-operative symptoms of mania.
  
  
  METHODS
  In a structured clinical assessment, the patient's mood status, psychiatric diagnosis and sleep functioning - sleep onset latency, total sleep time, wake after sleep onset - were assessed. The sleep-wake cycle and daily mood was measured for 11 consecutive days.
  
  
  RESULTS
  The patient met diagnostic criteria for bipolar disorder (excluding the requirement that the disturbance must not be due to a medical disorder) and delayed sleep-phase syndrome. Across 11 days, the patient exhibited elevated positive, but not negative, mood. Correlational analyses indicated a possible association between mood and sleep disturbance.
  
  
  CONCLUSIONS
  This pattern of findings implicates the temporal lobe in positive mood regulation and sleep-related impairments.
authors.affiliation: University of California, Berkeley, CA, USA.
authors.forename: June
authors.initials: J
authors.lastname: Gruber
authors.forename: Julie N
authors.initials: JN
authors.lastname: Lemoine
authors.forename: Robert T
authors.initials: RT
authors.lastname: Knight
authors.forename: Allison G
authors.initials: AG
authors.lastname: Harvey
mesh_terms: D000339:Affect; D001714:Bipolar Disorder / Q000209:etiology* / Q000523:psychology; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000523:psychology; D013702:Temporal Lobe / Q000473:pathology*