Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (alpha-aminoacyl)benzotriazoles.
A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(alpha-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Khashab
Niveen M
NM
Yoshioka
Megumi
M
Haase
Danniebelle N
DN
Wilson
Krista R
KR
Johnson
Jodie V
JV
Chung
Alfred
A
Haskell-Luevano
Carrie
C
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
D001555:Benzene Derivatives; D010455:Peptides; D014230:Triazoles