Crescentic transformation in primary membranous glomerulopathy: association with anti-GBM antibody.
Crescentic transformation of primary membranous nephropathy (MN) associated with the development of anti-GBM antibody is a rare cause of acute renal failure in patients with MN. We report a 54-year-old lady, diagnosed to have MN four years earlier, who presented with acute deterioration of renal functions. Renal biopsy revealed circumferential crescents in all glomeruli. Serum anti-GBM antibodies were positive. Despite therapy with plasmapheresis, steroids and oral cyclophosphamide, she did not improve and continues to be dialysis dependent.
Nayak
Shobhana G
SG
Department of Nephrology, St. John's Medical College Hospital, Bangalore, India. nayak_shobhana@rediffmail.com
Satish
Renuka
R
D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008875:Middle Aged
D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody