McArdle disease with rhabdomyolysis induced by rosuvastatin: case report.
The rosuvastatin inducing rhabdomyolysis in McArdle disease (MD) has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatine-kinase levels and the forearm ischemic exercise did not increase venous lactate. The muscle biopsy showed subsarcolemmal and central accumulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.
Lorenzoni
Paulo José
PJ
Neuromuscular/Neurology Division, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro 181, 80060-900 Curitiba, PR, Brazil.
Silvado
Carlos Eduardo
CE
Scola
Rosana Herminia
RH
Luvizotto
Mario
M
Werneck
Lineu César
LC
D000328:Adult; D005464:Fluorobenzenes / Q000009:adverse effects* / Q000627:therapeutic use; D006012:Glycogen Storage Disease Type V / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use
D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium