How mice cope with stressful social situations.
Individuals differ greatly in their psychological responses to chronic stress. As a step toward understanding the neural basis for these individual differences, Krishnan et al. (2007) reveal molecular changes in the brain's reward circuits that make some mice resistant to the effects of social defeat.
Hyman
Steven E
SE
Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, MA 02138, USA. seh@harvard.edu
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000502:physiology*; D003863:Depression / Q000378:metabolism; D051379:Mice; D012201:Reward; D015398:Signal Transduction; D012919:Social Behavior; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*
D019208:Brain-Derived Neurotrophic Factor