Coherence analysis over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy.
A total of 32 microwire electrodes were implanted bilaterally into the hippocampus of Sprague-Dawley rats, which were then stimulated in the manner prescribed for the chronic limbic epilepsy model. After the initial seizure brought on by the stimulation, the animals were recorded at a high sampling rate (approximately 12 kHz) for the entire duration of the latent period. Coherence was calculated across channels in both stimulated (and later seizing) animals and non-stimulated (and thus non-seizing control) animals. Average coherence over time was greatest in intrahemispherical electrode pairs in both stimulated and non-stimulated animals. However, the 200-800 Hz band displays increased coherence interhemispherically and up to 200 Hz band displays decreased coherence interhemispherically: this occurs only in stimulated animals.
Simonotto
Jennifer D
JD
Department of Biomedical Engineering, Florida University, Gainesville, FL, USA.
Myers
Stephen M
SM
Furman
Michael D
MD
Norman
Wendy M
WM
Liu
Zhao
Z
DeMarse
Thomas B
TB
Carney
Paul R
PR
Ditto
William L
WL
D000465:Algorithms; D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D054022:Cerebrum / Q000503:physiopathology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology*; D008959:Models, Neurological; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time