title: Drug-eluting stent implantation results in effective treatment of small coronary artery disease (DESIRE Small CAD).
abstract: OBJECTIVE
  Sirolimus-eluting stents (SES) have been shown to significantly reduce restenosis in the treatment of lesions in large coronary arteries. We assessed and compared the in-hospital and long-term outcomes of patients treated with SES and bare-metal stents (BMS) for small coronary artery disease.
  
  
  METHODS
  We compared 448 patients who underwent SES implantation in small coronary arteries (<2.5mm) with patients who received conventional BMS (n=124). In-hospital and nine-month events were evaluated.
  
  
  RESULTS
  The rate of angiographic restenosis at nine months was significantly lower in the SES group (1.6% vs 9.9%, P<0.001) than in the BMS group. The overall rate of MACE was 4.3% in SES and 13.9% in BMS groups (P<0.001).
  
  
  CONCLUSIONS
  As compared with BMS, SES placement in small coronary arteries is effective and associated with a marked reduction in restenosis rate and the subsequent need for target lesion revascularization at nine months.
authors.affiliation: Division of Interventional Cardiology, The Henry Low Heart Center, Hartford Hospital, Hartford, USA. igor_mamkin@yahoo.com
authors.forename: Igor
authors.initials: I
authors.lastname: Mamkin
authors.forename: Rachid A
authors.initials: RA
authors.lastname: Elkoustaf
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Mather
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Kiernan
authors.forename: Raymond G
authors.initials: RG
authors.lastname: McKay
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D002317:Cardiovascular Agents / Q000008:administration & dosage; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents
chemical_list: D002317:Cardiovascular Agents; D020123:Sirolimus