title: Evaluation of two different potency tests for leptospirosis vaccine vax-SPIRAL.
abstract: Two different potency tests were evaluated, consisting in one-dilution used to determine 50% lethal dose (LD50) and four--dilution used to calculate 50% effective dose (ED50), respectively. Our experience has led to propose the four-dilution test for routine lot releasing.
authors.affiliation: Instituto Finlay, Ciudad de La Habana, Cuba. jnunez@finlay.edu.cu
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Núñez
authors.forename: Ester María
authors.initials: EM
authors.lastname: Fajardo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pérez
authors.forename: Ivis
authors.initials: I
authors.lastname: Ontivero
authors.forename: Deolinda
authors.initials: D
authors.lastname: Silva
authors.forename: Pedro
authors.initials: P
authors.lastname: Muñoz
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000592:standards* / Q000633:toxicity; D006224:Cricetinae; D003462:Cuba; D005500:Follow-Up Studies; D007919:Leptospira / Q000276:immunology* / Q000472:pathogenicity; D007922:Leptospirosis / Q000517:prevention & control*; D007928:Lethal Dose 50; D013997:Time Factors; D018675:Toxicity Tests
chemical_list: D001428:Bacterial Vaccines