Synapse specificity: Wnts keep motor axons on target.
New studies on the molecular logic of synapse specificity in the fly and worm have brought neurobiologists back to an ancient family of morphogens best known for establishing pattern in the early embryonic nervous system.
Lu
Cecilia S
CS
Department of Cell Biology and Program in Neuroscience, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
Van Vactor
David
D
D000818:Animals; D001369:Axons / Q000502:physiology; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008959:Models, Neurological; D009420:Nervous System / Q000196:embryology*; D013569:Synapses / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D051153:Wnt Proteins