title: Postgenomics of Neisseria meningitidis for vaccines development.
abstract: Meningococcal disease is a global problem. Multivalent (A, C, Y, W135) conjugate vaccines have been developed and licensed; however, an effective vaccine against serogroup B has not yet become available. Outer membrane vesicle (OMV) vaccines have been used to disrupt serogroup B epidemics and outbreaks. Postgenomic technologies have been useful in aiding the discovery of new protein vaccine candidates. Moreover, proteomic technologies enable large-scale identification of membrane and surface-associated proteins, and provide suitable methods to characterize and standardize the antigen composition of OMV-based vaccines.
authors.affiliation: Università degli Studi di Siena, Dipartimento di Biologia Molecolare, via Fiorentina 1, 53100 Siena, Italy. bernardini@unisi.it
authors.forename: Giulia
authors.initials: G
authors.lastname: Bernardini
authors.forename: Daniela
authors.initials: D
authors.lastname: Braconi
authors.forename: Paola
authors.initials: P
authors.lastname: Martelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Santucci
mesh_terms: D023281:Genomics / Q000379:methods*; D006801:Humans; D008589:Meningococcal Infections / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000235:genetics / Q000276:immunology*; D009345:Neisseria meningitidis / Q000235:genetics* / Q000276:immunology*; D040901:Proteomics
chemical_list: D022401:Meningococcal Vaccines