A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity.
Palacios
Daniel S
DS
Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Anderson
Thomas M
TM
Burke
Martin D
MD
D000666:Amphotericin B / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D048630:Polyketide Synthases / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000935:Antifungal Agents; D048630:Polyketide Synthases; D000666:Amphotericin B