title: Effect of strontium ranelate on fracture healing in rat tibia.
abstract: OBJECTIVE
  Various anti-osteoporotic agents are available for clinical use. In contrast to other anti-osteoporotic drugs, strontium ranelate has anti-resorptive and bone-forming effects (dual action). Our objective in the present study is to investigate the efficacy of strontium ranelate (SR) on fracture healing in rat tibia.
  
  
  METHODS
  Forty-two male Wistar rats randomized into two groups (groups 1 and 2, n=21 for each). Left tibiae of all animals were broken in a closed manner using a manual three-point bending technique through mid-tibia following deep anesthesia with ketamine. The animals in group 1 were fed 25g/day specially produced food containing 450mg/kg SR starting from the first post-operative day. Group 2 were given 25g/day normal food. The animals were sacrificed on the 2nd, 3rd and 4th post-operative weeks (each week 7 animals were sacrificed from each group) and the broken tibiae were removed. The tibiae were examined first radiographically and second, histopathologically.
  
  
  RESULTS
  Radiologically, callus maturity and bone union increased with time in both groups. But no significant differences were found regarding callus maturity and bone union in weekly comparisons (p=0.52, p=0.19, p=0.74).
  
  
  CONCLUSIONS
  Histopathologically, it was seen that the fractures remarkably healed steadily in both groups on the 2nd, 3rd and 4th post-operative weeks. But no significant differences were found regarding the progression of fracture callus in weekly comparison (p=1.0, p=0.52, p=1.0). In the present study, we were unable to find any beneficial or harmful effects of strontium ranelate on fracture healing.
authors.affiliation: Gaziantep University Faculty of Medicine, Orthopedic and Traumatology Department, 27060 Gaziantep, Sahinbey, Turkey. ocebesoy@yahoo.com
authors.forename: Oguz
authors.initials: O
authors.lastname: Cebesoy
authors.forename: Ediz
authors.initials: E
authors.lastname: Tutar
authors.forename: Kamil Cagri
authors.initials: KC
authors.lastname: Kose
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Baltaci
authors.forename: Cahit
authors.initials: C
authors.lastname: Bagci
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D013876:Thiophenes / Q000494:pharmacology*; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000293:injuries / Q000473:pathology
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate