[Tumor angiogenesis].
Following the work of Folkman, it appears that angiogenesis, which consists in the formation of new blood vessels able to deliver oxygen and nutriments to tumor cells, is a major step in the evolution of tumors, which can only grow after the onset of the angiogenic switch. Numerous factors play a role in angiogenesis stimulation or inhibition : the vascular endothelial growth factor and fibroblastic growth factors as well as angiopoietin are proangiogenic, whereas angiostatin and platelet factor 4 are anti-angiogenic. The discovery of these molecules and of the molecular mechanisms of their activity allowed the identification of new therapeutic targets, which appear relevant for the treatment of cancer.
Bikfalvi
Andreas
A
Laboratoire des mécanismes moléculaires de l'angiogenèse, Inserm E0113, Université de Bordeaux I, avenue des Facultés, 33405 Talence. a.bikfalvi@angio.u-bordeaux1.fr
D042682:Angiopoietins / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D042442:Vascular Endothelial Growth Factors / Q000502:physiology*
D042682:Angiopoietins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors