Streptomyces coelicolor undergoes spontaneous chromosomal end replacement.
We report a previously unobserved form of genetic instability for Streptomyces coelicolor, the replacement of one chromosome end by the other end. These genetic changes occurred spontaneously in both a wild-type strain and strains harboring a foreign transposon. Deleted and duplicated DNA comprises up to 33% of the genome.
Widenbrant
Elizabeth M
EM
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA. ewidenbrant@gmail.com
Tsai
Hsiu-Hui
HH
Chen
Carton W
CW
Kao
Camilla M
CM
D002876:Chromosomes, Bacterial / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D011995:Recombination, Genetic; D048372:Streptomyces coelicolor / Q000235:genetics*
D004269:DNA, Bacterial