Ornithine decarboxylase activity as a prognostic marker for colorectal cancer.
Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435+/-392, 154+/-173, 295+/-202, 103+/-60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (> or =350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery.
Hoshino
Yutaka
Y
Department of Surgery I, Fukushima Medical University School of Medicine, Japan. yhoshino@fmu.ac.jp
Terashima
Shinya
S
Teranishi
Yasushi
Y
Terashima
Masanori
M
Kogure
Michihiko
M
Saitoh
Takuroh
T
Osuka
Fumihiko
F
Kashimura
Seigo
S
Saze
Zenichiroh
Z
Gotoh
Mitsukazu
M
D000236:Adenoma / Q000201:enzymology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011379:Prognosis
D014408:Biomarkers, Tumor; D009955:Ornithine Decarboxylase