title: Targeting V(D)J recombinase: putting a PHD to work.
abstract: In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H3K4 trimethylation. Because this mark associates with active promoters, the finding forges a new link between transcription, epigenetics, and recombinase targeting during lymphocyte development.
authors.affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232, USA. eugene.oltz@vanderbilt.edu
authors.forename: Eugene M
authors.initials: EM
authors.lastname: Oltz
authors.forename: Oleg
authors.initials: O
authors.lastname: Osipovich
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D005803:Genes, Immunoglobulin; D006801:Humans; D008214:Lymphocytes; D008957:Models, Genetic; D018448:Models, Immunological; D014158:Transcription, Genetic; D045567:VDJ Recombinases / Q000378:metabolism*
chemical_list: D045567:VDJ Recombinases