Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver--histological and histochemical study.
Effect of drug praziquantel (PZQ) and C. longa extract on S. mansoni infected mice is reported. The level of glycogen, alkaline and acid phosphatases (ALP and ACP respectively), and body weight, liver weight and liver weight/body weight ratio were studied in mice infected with S. mansoni. ALP level was increased after infection. C. longa treated mice showed marked reduction in ALP level more than after PZQ-treatment. C. longa enhanced the concentration of glycogen after being reduced by infection, while PZQ-treatment revealed more reduction. C. longa caused enhancement in body weight while PZQ treatment had no effect. The formation of granuloma around schistosome eggs in the liver produced inflammation. C. longa extract and PZQ were effective in reducing granuloma size in infected mice.
El-Banhawey
Mahmoud A
MA
Department of Experimental Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.
Ashry
Madeha A
MA
El-Ansary
Afaf K
AK
Aly
Sanaa A
SA
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D030024:Curcuma / Q000737:chemistry*; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000469:parasitology / Q000473:pathology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology / Q000473:pathology*
D010936:Plant Extracts; D011223:Praziquantel; D000469:Alkaline Phosphatase