Vancomycin degradation products as potential chiral selectors in enantiomeric separation of racemic compounds.
This review discusses the use of vancomycin-related substances as potential chiral stationary phase that can be used as a packing material for the enantioselective separation of various racemic compounds in various modalities including HPLC, CE and also as chiral mobile phase additives. The chiral recognition mechanisms involved including the role of dimerization are presented.
Ghassempour
Alireza
A
Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran.
Aboul-Enein
Hassan Y
HY
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D019281:Dimerization; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D013237:Stereoisomerism; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry*
D014640:Vancomycin