Biotransformation of myrislignan by rat liver microsomes in vitro.
Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively.
Li
Fei
F
The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
Yang
Xiu-Wei
XW
D000818:Animals; D001711:Biotransformation; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008862:Microsomes, Liver / Q000737:chemistry* / Q000378:metabolism*; D008968:Molecular Conformation; D026323:Myristica / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism
D017705:Lignans