Cushing's syndrome in women with polycystic ovaries and hyperandrogenism.
BACKGROUND
A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae.


METHODS
Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses.


METHODS
Cushing's syndrome due to a right adrenocortical adenoma.


RESULTS
The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities.
Fegan
P Gerry
PG
School of Medicine, University of Southampton, Duthie Building / Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
Sandeman
Derek D
DD
Krone
Nils
N
Bosman
Deborah
D
Wood
Peter J
PJ
Stewart
Paul M
PM
Hanley
Neil A
NA
D000315:Adrenalectomy / Q000379:methods; D018246:Adrenocortical Adenoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery