title: Bioactive glass granules as extender of autogenous bone grafting in cementless intercalary implant of the canine femur.
abstract: OBJECTIVE
  Ceramic bone graft substitutes have a potential to be used as replacement of allogeneic bone grafting and, under optimal distribution of particle size, they may even provide mechanical support. The current study examined the efficacy of bioactive glass granules as an extender of autogenous bone grafting in a segmental bone replacement model of the canine femur.
  
  
  METHODS
  A 16 mm long segment of the femur shaft was bilaterally replaced with an intercalary titanium implant in eight animals. The implant had cementless grooved proximal and distal stems. In one leg, the peri-implant space was packed with composite graft consisting of a mixture of bioactive glass granules and autogenous bone graft in proportion of 50:50. In the opposite leg, the peri-implant space was treated with autogenous bone graft alone. After surgery, unlimited functional loading was allowed. The outcome was evaluated at three months.
  
  
  RESULTS
  Eight out of sixteen autografted implants and seven out of sixteen composite-grafted implants were radiographically incorporated and clinically stable at three months. In the paired comparison, the proximal components of composite-grafted implants showed lower maximum load under torsional testing (p = 0.068), less new bone in the longitudinal grooves of the stems (p = 0.036) and lower affinity of new bone to implant surface (p = 0.046). The distal components of the two sides showed a similar trend for less new bone in the grooves and lower bone affinity of new bone in the distal composite-grafted components.
  
  
  CONCLUSIONS
  The current study suggests that supplementation of periprosthetic bone graft with bioactive ceramic particles may not help to promote healing of cementless implants under high dynamic loading conditions.
authors.affiliation: Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Keränen
authors.forename: A
authors.initials: A
authors.lastname: Itälä
authors.forename: J
authors.initials: J
authors.lastname: Koort
authors.forename: I
authors.initials: I
authors.lastname: Kohonen
authors.forename: M
authors.initials: M
authors.lastname: Dalstra
authors.forename: B
authors.initials: B
authors.lastname: Kommonen
authors.forename: H T
authors.initials: HT
authors.lastname: Aro
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D016025:Bone Transplantation / Q000379:methods*; D002516:Ceramics / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006085:Graft Survival; D011474:Prosthesis Design; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: C081271:BAS O glass ceramic; D001672:Biocompatible Materials