title: Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.
abstract: The correct assembly of the BACE (beta-site amyloid precursor protein-cleaving enzyme or beta-secretase) complex and its subsequent trafficking to cellular compartments where it associates with the APP (amyloid precursor protein) is essential for the production of Abeta (amyloid beta-peptide), the protein whose aggregation into senile plaques is thought to be responsible for the pathogenesis of AD (Alzheimer's disease). These processes rely upon both transient and permanent BACE-protein interactions. This review will discuss what is currently known about these BACE-protein interactions and how they may reveal novel therapeutic targets for the treatment of AD.
authors.affiliation: Department of Basic Medical Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, U.K. r.parsons@sgul.ac.uk
authors.forename: R B
authors.initials: RB
authors.lastname: Parsons
authors.forename: B M
authors.initials: BM
authors.lastname: Austen
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D019281:Dimerization; D006801:Humans; D019308:Palmitic Acid / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport; D013347:Subcellular Fractions / Q000378:metabolism*
chemical_list: D019308:Palmitic Acid; D002784:Cholesterol; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human