Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis.
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
Scagnolari
Carolina
C
Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy.
Midulla
Fabio
F
Trombetti
Simona
S
Pierangeli
Alessandra
A
Tromba
Valeria
V
Grossi
Rosanna
R
Di Marco
Paola
P
Dianzani
Caterina
C
Girardi
Enrico
E
Antonelli
Guido
G
D001988:Bronchiolitis / Q000235:genetics* / Q000503:physiopathology / Q000821:virology; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007223:Infant; D007372:Interferons / Q000494:pharmacology*; D010101:Oxygen Consumption; D016133:Polymerase Chain Reaction; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012229:Rhinovirus / Q000302:isolation & purification
D016207:Cytokines; D007372:Interferons