Therapeutic effects of glyprolines (PGP, GP, and PG) in rats with stress-induced behavioral disorders.
Experiments on male outbred albino rats showed that stress (10-min swimming) increased anxiety and inhibited orientation and exploratory activities. Poststress (15 min after the end of swimming) intranasal administration of peptides Pro-Gly-Pro and Gly-Pro in a dose of 3.7 micromol/kg prevented stress-induced behavioral disorders. This effect persisted for 3 h.
Kopylova
G N
GN
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. kopylovagn@list.ru
Bakaeva
Z V
ZV
Badmaeva
S E
SE
Umarova
B A
BA
Samonina
G E
GE
Guseva
A A
AA
D000818:Animals; D021461:Animals, Outbred Strains; D001522:Behavior, Animal / Q000187:drug effects; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects; D040921:Stress Disorders, Traumatic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications*; D013550:Swimming
D004151:Dipeptides; D018696:Neuroprotective Agents; D009842:Oligopeptides; C015248:glycylproline