title: F-19848 A, a novel inhibitor of hyaluronic acid binding to cellular receptor CD44.
abstract: In the course of our screening for inhibitors of hyaluronic acid (HA) binding to cellular receptor CD44, a novel inhibitor, F-19848 A, was isolated from the cultured broth of the fungus strain Dacrymyces sp. SANK 20204. This compound inhibited the binding of CD44 and HA with an IC50 value of 23.5 microM and CD44-dependent HA degradation was inhibited with an IC50 value of 98.6 microM in a cell-based assay. The structure was elucidated by physico-chemical properties, analysis of spectral data, and decomposition experiments.
authors.affiliation: Advanced Technology Research Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirota-Takahata
authors.forename: Hosami
authors.initials: H
authors.lastname: Harada
authors.forename: Isshin
authors.initials: I
authors.lastname: Tanaka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakata
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Nakajima
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D001487:Basidiomycota / Q000737:chemistry / Q000648:ultrastructure; D001667:Binding, Competitive / Q000187:drug effects; D002240:Carbohydrate Sequence; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005227:Fatty Acids / Q000737:chemistry; D005285:Fermentation; D005947:Glucose / Q000737:chemistry; D018960:Hyaluronan Receptors / Q000187:drug effects* / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014994:Xylose / Q000737:chemistry
chemical_list: C525997:F-19848 A; D005227:Fatty Acids; D018960:Hyaluronan Receptors; D009844:Oligosaccharides; D006820:Hyaluronic Acid; D014994:Xylose; D005947:Glucose