title: Comparison of two and three-dimensional optical tomographic image reconstructions of human finger joints.
abstract: We have developed an images reconstruction algorithm to recover spatial distribution of optical properties in human finger joints for early diagnosis and monitoring of rheumatoid arthritis (RA). An optimization method iteratively employs a light propagation and scattering coefficients distribution for near-infrared (NIR) light inside the joint tissue. We developed the differences in cross-sectional images obtained by using the reconstruction algorithms with 2-dimensional and 3-dimensional light propagation models. In particular we examined how these different approaches affect the discrimination between healthy and RA joints.
authors.affiliation: Depts. of Biomedical Engineering and Radiology at Columbia University, New York, NY 10027 USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Song
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Klose
authors.forename: Alexander K
authors.initials: AK
authors.lastname: Scheel
authors.forename: Uwe
authors.initials: U
authors.lastname: Netz
authors.forename: Jurgen
authors.initials: J
authors.lastname: Beuthan
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
mesh_terms: D000465:Algorithms; D005384:Finger Joint / Q000033:anatomy & histology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D041622:Tomography, Optical / Q000379:methods*