Gene-environment interactions in asthma.
The underlying pathogenesis of asthma, one of the most common chronic diseases of childhood, is not fully understood. There is a well-documented heritable component to this disease and environmental factors associated with a Westernised lifestyle have also been implicated; recent studies suggest gene-environment interactions are important in the development of this disease. In the absence of a previous review in children, the present report presents the accumulating evidence for gene-environment interactions in asthma pathogenesis. Studies of these interactions in different populations have yielded both expected and unexpected results. This is a new and rapidly developing field where there are currently many more questions than answers.
McLeish
S
S
Department of Child Health, University of Aberdeen, Aberdeen, UK.
Turner
S W
SW
D001249:Asthma / Q000209:etiology*; D001424:Bacterial Infections / Q000276:immunology; D002648:Child; D004777:Environment; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D018384:Oxidative Stress; D051193:Toll-Like Receptors / Q000235:genetics
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D018950:Lipopolysaccharide Receptors; D051193:Toll-Like Receptors; C413545:glutathione S-transferase T1