Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction.
A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields.
Pal
Sarbani
S
Department of Chemistry, MNR Post Graduate College, Kukatpally, Hyderabad-500072, India. sarbani277@yahoo.com
Khan
Mohammad Ashrafuddin
MA
Bindu
P
P
Dubey
P K
PK