Regulatory role of cathepsin D in apoptosis.
Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.
Minarowska
Alina
A
3rd Department of Children's Diseases, Medical University of Białystok, Poland. minar@mp.pl
Minarowski
Lukasz
L
Karwowska
Alicja
A
Gacko
Marek
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002402:Cathepsin D / Q000502:physiology*; D006801:Humans
D002402:Cathepsin D