HIV-1 drug-resistance and drug-dependence.
In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1 variants is also discussed.
Baldwin
Chris
C
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, the Netherlands. baldwin_ce@hotmail.com
Berkhout
Ben
B
D019380:Anti-HIV Agents / Q000009:adverse effects*; D004351:Drug Resistance; D000077560:Enfuvirtide; D014644:Genetic Variation; D015700:HIV Envelope Protein gp41 / Q000627:therapeutic use; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D010446:Peptide Fragments / Q000627:therapeutic use; D010641:Phenotype; D014759:Viral Envelope Proteins / Q000235:genetics
D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D014759:Viral Envelope Proteins; D000077560:Enfuvirtide