Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis.
To investigate whether mitochondrial oxidative damage contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis (sALS), we used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) in the cerebrospinal fluid (CSF) of 30 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients were significantly greater than those in the CSF of controls (P<0.002) and were negatively correlated with duration of illness (rho=-0.64, P<0.001). These results suggest that mitochondrial oxidative damage contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis.
Murata
Takahiko
T
Department of Neurology, Iwate Prefectural Ninohe Hospital 38 Horino Aza Ookawarake Ninohe, Iwate 028-6193 Japan. takahm@nyc.odn.ne.jp
Ohtsuka
Chigumi
C
Terayama
Yasuo
Y
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000503:physiopathology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000503:physiopathology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid
D015415:Biomarkers; D014451:Ubiquinone; C024989:coenzyme Q10