title: Mineral metabolism and vascular damage in children on dialysis.
abstract: Cardiovascular disease is increasingly recognized as a life-limiting problem in young patients with chronic kidney disease, but there are few studies in children that describe its determinants. We studied the association of intact parathyroid hormone (iPTH) levels and their management on vascular structure and function in 85 children, ages 5-18 years, who had received dialysis for > or =6 months. Compared to controls, dialysis patients had increased carotid intima-media thickness and pulse-wave velocity. All vascular measures positively correlated with serum phosphorus levels, while carotid intima-media thickness and cardiac calcification score also correlated with iPTH levels. Patients with mean time-integrated iPTH levels less than twice the upper limit of normal (n = 41) had vascular measures that were comparable to age-matched controls, but those with iPTH levels greater than twice the upper limit of normal (n = 44) had greater carotid intima-media thickness, stiffer vessels, and increased cardiac calcification than controls. Patients with increased carotid intima-media thickness had stiffer vessels and a greater prevalence of cardiac calcification. There was a strong dose-dependent correlation between vitamin D and all vascular measures, and calcium intake from phosphate binders weakly correlated with carotid intima-media thickness. In conclusion, both iPTH level and dosage of vitamin D are associated with vascular damage and calcification in children on dialysis.
authors.affiliation: Department of Nephrourology, Great Ormond Street Hospital and Institute of Child Health, London, United Kingdom. ShrofR@gosh.nhs.uk
authors.forename: Rukshana C
authors.initials: RC
authors.lastname: Shroff
authors.forename: Ann E
authors.initials: AE
authors.lastname: Donald
authors.forename: Melanie P
authors.initials: MP
authors.lastname: Hiorns
authors.forename: Alan
authors.initials: A
authors.lastname: Watson
authors.forename: Sally
authors.initials: S
authors.lastname: Feather
authors.forename: David
authors.initials: D
authors.lastname: Milford
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Ellins
authors.forename: Clare
authors.initials: C
authors.lastname: Storry
authors.forename: Deborah
authors.initials: D
authors.lastname: Ridout
authors.forename: John
authors.initials: J
authors.lastname: Deanfield
authors.forename: Lesley
authors.initials: L
authors.lastname: Rees
mesh_terms: D000293:Adolescent; D001783:Blood Flow Velocity / Q000502:physiology; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000473:pathology* / Q000628:therapy; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D006435:Renal Dialysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D010281:Parathyroid Hormone