Thermoregulation: channels that are cool to the core.
TRP channels are molecular sensors that endow animals with the ability to sense external temperatures. Recent studies have provided strong evidence that at least one TRP channel, TRPV1, is also essential for the maintenance of internal body temperature.
Montell
Craig
C
Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cmontell@jhmi.edu
Caterina
Michael J
MJ
D000178:Acrylamides / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000502:physiology*
D000178:Acrylamides; C521703:N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide; D011725:Pyridines; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; C493922:Trpv1 protein, rat