Episodic-like memory in Ts65Dn, a mouse model of Down syndrome.
Ts65Dn mice, like individuals with Down syndrome (DS), demonstrate a functional dissociation between explicit and implicit forms of memory, showing selective impairment in explicit or declarative learning tasks. Here, we explored Ts65Dn explicit memory deficits further by evaluating the ability of these mice to assimilate the temporal and spatial contexts under which previously novel objects had been encountered. We found that Ts65Dn mice could in fact form contextual representations of objects over the course of a few hours, contrary to their inability to discriminate object novelty over a more prolonged period of 24h. These results suggest that Ts65Dn mice might have particular difficulties in declarative tasks requiring long-term memory, presenting an especially important putative therapeutic target for pre-clinical and clinical DS research.
Fernandez
Fabian
F
Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, 1201 Welch Rd., Palo Alto, CA 94304-5485, USA.
Garner
Craig C
CC
D000818:Animals; D004193:Discrimination Learning / Q000502:physiology*; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics / Q000503:physiopathology*; D005106:Exploratory Behavior / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics / Q000503:physiopathology*; D051379:Mice; D008817:Mice, Mutant Strains; D013037:Spatial Behavior / Q000502:physiology; D013998:Time Perception / Q000502:physiology; D014314:Trisomy