title: Diabetes and the heart: could the diabetic myocardium be protected by preconditioning?
abstract: Both type 1 and type 2 diabetes (insulin-dependent and non-insulin dependent diabetes, respectively) are associated with increased risk for microvascular and macrovascular complications including retinopathy, neuropathy, nephropathy and atherosclerosis. Type 2 diabetes markedly increases the risk for cardiovascular morbidity and mortality, which has major public health implications. In this review, molecular mechanisms pertaining to diabetes-induced heart pathology are addressed.
authors.affiliation: Department of Cellular Biochemistry and Human Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vinokur
authors.forename: Gil
authors.initials: G
authors.lastname: Leibowitz
authors.forename: Leonid
authors.initials: L
authors.lastname: Grinberg
authors.forename: Ron
authors.initials: R
authors.lastname: Eliashar
authors.forename: Eduard
authors.initials: E
authors.lastname: Berenshtein
authors.forename: Mordechai
authors.initials: M
authors.lastname: Chevion
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D048909:Diabetes Complications / Q000473:pathology*; D006331:Heart Diseases / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008954:Models, Biological; D008956:Models, Chemical; D009206:Myocardium / Q000473:pathology*; D018384:Oxidative Stress; D015221:Potassium Channels / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species; D015398:Signal Transduction
chemical_list: D015221:Potassium Channels; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate