Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome.
OBJECTIVE
To investigate single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) gene that have significant associations with the pathogenesis of polycystic ovary syndrome (PCOS) in a Korean population.


METHODS
Case-control study.


METHODS
University-based hospital.


METHODS
One hundred thirty-four patients with PCOS and 100 healthy women as controls.


METHODS
None.


METHODS
Frequencies of genotypes for SNPs in VEGF gene, which were specifically expressed in a Korean population.


RESULTS
After genotypic analysis, we found that among 10 SNPs, one novel SNP at site +9812 and one known SNP at site +13553 have P values lower than .05 (+9812: odds ratio [95% confidence interval] 0.61 [0.39-0.95]; +13553: odds ratio [95% confidence interval] 0.59 [0.37-0.93]) and one haplotype (ht4) also has a P value in the significant range (odds ratio [95% confidence interval] 0.34 [0.16-0.74]).


CONCLUSIONS
We concluded that one novel SNP at +9812 site, one known SNP at +13553 site, and one selected haplotype in the VEGF gene have a high possibility of significant associations with the pathogenesis of PCOS in a Korean population.
Lee
Eung-Ji
EJ
Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea.
Oh
Bermseok
B
Lee
Jong-Young
JY
Kimm
Kuchan
K
Park
Jung-Mi
JM
Baek
Kwang-Hyun
KH
D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D005799:Genes, Dominant; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A