title: [Gene therapy in The Netherlands].
abstract: Extensive research is ongoing worldwide on the clinical utility of gene therapy, particularly for the treatment of cancer and genetic disorders. Two gene therapy products have already been approved recently in China. Clinical experience with gene therapy has also been accumulating in the Netherlands: over 200 Dutch patients have now been treated in clinical trials. Published results indicate that gene therapy is generally safe. Gene therapy appears to be effective for some genetic disorders, such as severe combined immune deficiency and haemophilia B. The efficacy of gene therapy, particularly in the treatment of cancer, appears to be limited up till now.
authors.affiliation: Erasmus MC-Centrum, Postbus 2040, 3000 CA Rotterdam. e.schenk-braat@erasmusmc.nl
authors.forename: E A M
authors.initials: EA
authors.lastname: Schenk-Braat
authors.forename: M M K B
authors.initials: MM
authors.lastname: van Mierlo
authors.forename: G A P
authors.initials: GA
authors.lastname: Hospers
authors.forename: G
authors.initials: G
authors.lastname: Wagemaker
authors.forename: C H
authors.initials: CH
authors.lastname: Bangma
authors.forename: L C M
authors.initials: LC
authors.lastname: Kaptein
mesh_terms: D002986:Clinical Trials as Topic; D005544:Forecasting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D009426:Netherlands; D012449:Safety