title: Imaging the mechanics and electromechanics of the heart.
abstract: The heart is a mechanical pump that is electrically driven. We have previously shown that the contractility of the cardiac muscle can reliably be used in order to assess the extent of ischemia using myocardial elastography. Myocardial elastography estimates displacement and strain during the natural contraction of the myocardium using signal processing techniques on echocardiograms in order to assess the change in mechanical properties as a result of disease. In this paper, we showed that elastographic techniques can be used to estimate and image both the mechanics and electromechanics of normal and pathological hearts in vivo. In order to image the mechanics throughout the entire cardiac cycle, the minimum frame rate was determined to be on the order of 150 fps in a long-axis view and 300 fps in a short-axis view. The incremental and cumulative displacement and strains were measured and imaged for the characterization of normal function and differentiation from infracted myocardium. In order to image the electromechanical function, the incremental displacement was imaged inconsecutive cardiac cycles during end-systole in both dogs and humans. The contraction wave velocity in normal dogs was found to be twice higher than in normal humans and twice lower than in ischemic dogs. In conclusion, we have demonstrated that elastographic techniques can be used to detect and quantify the mechanics and electromechanics of the myocardium in vivo. Ongoing investigations entail assessment of myocardial elastography in characterizing and quantifying ischemia and infarction in vivo.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. ek2191@columbia.edu
authors.forename: Elisa E
authors.initials: EE
authors.lastname: Konofagou
authors.forename: Simon
authors.initials: S
authors.lastname: Fung-Kee-Fung
authors.forename: Jianwen
authors.initials: J
authors.lastname: Luo
authors.forename: Mathieu
authors.initials: M
authors.lastname: Pernot
mesh_terms: D000818:Animals; D003971:Diastole / Q000502:physiology; D004285:Dogs; D004452:Echocardiography; D004548:Elasticity; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology; D013599:Systole / Q000502:physiology; D016276:Ventricular Function