title: Relationship between arterial vascular calcifications seen on screening mammograms and biochemical markers of endothelial injury.
abstract: To assess whether breast arterial calcifications (BAC) are associated with altered serum markers of cardiovascular risk, mammograms and records from 1759 women (age range: 45-65 years) screened for breast cancer were revised. One hundred and forty seven (8.36%) women showed BAC. A total of 136 women with BAC and controls (mean age: 57 and 55 years, respectively) accepted entering the study. There were no significant differences in serum levels of urea, glucose, uric acid, creatinine, total cholesterol, HDL-C, LDL-C, folic acid, vitamin B(12), TSH or cysteine, between both groups of patients. However, women with BAC showed higher serum levels of triglycerides (p=0.006), homocysteine (p=0.002) and hs-CRP (p=0.003) than women without BAC. Likewise, we found a significantly higher percentage of cases with an elevated LDL-C/HDL-C ratio (coronary risk index >2) amongst women with BAC than in women without BAC (56.7 and 38.2%, respectively; p=0.04). Our results indicate that the finding of BAC identify women showing altered serum markers of cardiovascular risk.
authors.affiliation: Unidad de Investigación del, Hospital de Jove, Gijón, Spain. dpidal@hotmail.com
authors.forename: Diego
authors.initials: D
authors.lastname: Pidal
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Sánchez Vidal
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: M Daniela
authors.initials: MD
authors.lastname: Corte
authors.forename: Paz
authors.initials: P
authors.lastname: Pravia
authors.forename: Oscar
authors.initials: O
authors.lastname: Guinea
authors.forename: Iván
authors.initials: I
authors.lastname: Pidal
authors.forename: Miguel
authors.initials: M
authors.lastname: Bongera
authors.forename: Dámaso
authors.initials: D
authors.lastname: Escribano
authors.forename: Luis O
authors.initials: LO
authors.lastname: González
authors.forename: M Cruz
authors.initials: MC
authors.lastname: Díez
authors.forename: Rafael
authors.initials: R
authors.lastname: Venta
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vizoso
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D011859:Radiography; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D006710:Homocysteine; D002097:C-Reactive Protein; D002784:Cholesterol