Category specific deficits in Alzheimer's disease: fact or artefact?
Impairments in semantic memory commonly occur in Alzheimer's Disease (AD) but do these occur along category-specific lines? We administered a confrontation naming task comprising living and nonliving items to 68 individuals with AD and 59 age-matched control participants, in a study designed to address some of the methodological issues affecting investigation of category effects. In Experiment 1, stimuli were matched for familiarity and word frequency and also visual complexity, and the AD group showed a differential deficit in nonliving things. In Experiment 2, however, living and nonliving stimuli were matched for age-of-acquisition, name agreement, word frequency, and naming accuracy of elderly controls and there was no categorical impairment in the AD group. The AD group was subdivided first into mild and moderate AD, and then into normal or impaired overall naming groups and performance was reanalysed, but there was still no significant category deficit in any group. Converging evidence was provided by hierarchical regressions across items, as age-of-acquisition, name agreement and word frequency were significant predictors of naming performance in mild and moderate AD groups, but category was not. In Experiment 3, stimulus items were matched for familiarity and naming accuracy of elderly controls when their performance was off-ceiling, and again no differential effect of category was found. When we reduced slightly how closely matched stimuli were for familiarity we then found a differential impairment in living things in the AD group. When reviewing the changing pattern of results from use of different stimulus sets, we concluded that the main determinant of whether or not a categorical impairment of either sort is found in AD is which stimulus properties are controlled during stimulus selection. We conclude that AD does not generally lead to a selective category loss in semantic knowledge.
Tippett
Lynette J
LJ
Department of Psychology, University of Auckland, Auckland, New Zealand. l.tippett@auckland.ac.nz
Meier
Sandra L
SL
Blackwood
Kirsty
K
Diaz-Asper
Catherine
C
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D000704:Analysis of Variance; D016022:Case-Control Studies; D003210:Concept Formation; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008569:Memory Disorders / Q000145:classification / Q000150:complications*; D008875:Middle Aged; D012016:Reference Values; D012660:Semantics; D012720:Severity of Illness Index; D014705:Verbal Behavior / Q000502:physiology*