title: [A case of gastric cancer with severe lymph node metastasis effectively treated with docetaxel / S-1 as neoadjuvant chemotherapy].
abstract: A 75-year-old male patient had advanced gastric cancer with severe lymph node metastasis. He was treated with docetaxel 60 mg/body (day 1) and S-1 120 mg/body (2 weeks administration and 1 week rest) as neoadjuvant chemotherapy. After two courses of this neoadjuvant chemotherapy, the primary lesion and lymph node swelling were remarkably improved. The patient underwent total gastrectomy and D2 lymph node dissection. The histological effect was judged to be Grade 3, and no viable cancer cell was detected in the primary lesion and lymph node (pCR). Docetaxel and S-1 combination therapy were thought to be an effective method as neoadjuvant chemotherapy for advanced gastric cancer with severe lymph node metastasis.
authors.affiliation: Second Dept. of Surgery, Hirosaki University School of Medicine.
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsuya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Shibata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Sasaki
authors.forename: Jugoh
authors.initials: J
authors.lastname: Itoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage*; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid