GABA in regulation of communicative activity and sexual motivation of male mice with different psychoemotional status.
We studied the effects of drugs modulating GABA content in the brain on communicative activity and sexual motivation of male mice. The effects of the drug depended on animal genotype and initial psychoemotional status. Aminooxyacetic acid elevating GABA content did not modulate communicative activity of intact males, reduced it in aggressive animals, restored in anxious animals, and promoted exhaustion of sexual motivation in anxious animals. Thiosemicarbazide reducing GABA level produced an anxiogenic effect and destabilized sexual motivation in intact males.
Amikishieva
A V
AV
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. amik@bionet.nsc.ru
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D018682:GABA Agents / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012663:Semicarbazides / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D012919:Social Behavior; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000502:physiology
D018682:GABA Agents; D018757:GABA Modulators; D012663:Semicarbazides; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; C005151:thiosemicarbazide