Drug-eluting stent implantation results in effective treatment of small coronary artery disease (DESIRE Small CAD).
OBJECTIVE
Sirolimus-eluting stents (SES) have been shown to significantly reduce restenosis in the treatment of lesions in large coronary arteries. We assessed and compared the in-hospital and long-term outcomes of patients treated with SES and bare-metal stents (BMS) for small coronary artery disease.


METHODS
We compared 448 patients who underwent SES implantation in small coronary arteries (<2.5mm) with patients who received conventional BMS (n=124). In-hospital and nine-month events were evaluated.


RESULTS
The rate of angiographic restenosis at nine months was significantly lower in the SES group (1.6% vs 9.9%, P<0.001) than in the BMS group. The overall rate of MACE was 4.3% in SES and 13.9% in BMS groups (P<0.001).


CONCLUSIONS
As compared with BMS, SES placement in small coronary arteries is effective and associated with a marked reduction in restenosis rate and the subsequent need for target lesion revascularization at nine months.
Mamkin
Igor
I
Division of Interventional Cardiology, The Henry Low Heart Center, Hartford Hospital, Hartford, USA. igor_mamkin@yahoo.com
Elkoustaf
Rachid A
RA
Zhang
Qing
Q
Mather
Jeffrey F
JF
Kiernan
Francis J
FJ
McKay
Raymond G
RG
D000368:Aged; D000800:Angioplasty, Balloon; D002317:Cardiovascular Agents / Q000008:administration & dosage; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents
D002317:Cardiovascular Agents; D020123:Sirolimus