title: Effects of hydroxyapatite additive content on the bioactivity and biomechanical compatibility of bioactive nano-titania ceramics.
abstract: Bioactive nano-titania ceramics with excellent biomechanical compatibility and bioactivity were prepared by using hydroxyapatite (HA) additive as grain growth inhibitor with different contents. After sintered at 1000 degrees C with pressureless sintering method, the grain size of nano-titania ceramic was less than 70 nm. Mechanical test results showed that compressive strengths of the nano ceramics were from 137.5 to 275.6 MPa, elastic moduli from 7 to 8 GPa, and bending strengths from 38.67 to 111.96 MPa by increasing HA additive content from 1 to 20%. The mechanical properties of nano-titania ceramics were analogous to that of the human bone. The content of HA additive played an important role in adjusting the grain/particle size of nano-titania ceramics, which had a great effect on the osteoblasts proliferation in the cell culture experiments. The cell culture experiments also demonstrated that the bioactive HA additive itself also had a great effect on the cytocompatibility of the nano-titania ceramics. The results of the present study indicated that the content of HA additive not only had effect on the bioactivity of the nano-titania ceramics because of the bioactivity of the additive itself, but also had effect both on the biomechanical compatibility and bioactivity of the nano-titania ceramics by adjusting the grain/particle size of the ceramics.
authors.affiliation: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Qu
authors.forename: Bangcheng
authors.initials: B
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Hyun-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhao
authors.forename: Xingdong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000166:cytology; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry* / Q000627:therapeutic use; D017886:Durapatite / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology*; D010316:Particle Size; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite