title: Antibacterial thymol derivatives isolated from Centipeda minima.
abstract: Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Hengxing
authors.initials: H
authors.lastname: Liang
authors.forename: Fukai
authors.initials: F
authors.lastname: Bao
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Dong
authors.forename: Rui
authors.initials: R
authors.lastname: Tan
authors.forename: Caijun
authors.initials: C
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013943:Thymol / Q000031:analogs & derivatives*
chemical_list: D000900:Anti-Bacterial Agents; D039821:Monoterpenes; D013943:Thymol