[Expression of LIV-1 mRNA in human cervical carcinoma and endometrial carcinoma].
OBJECTIVE
To investigate the mRNA expression of oestrogen-regulated gene LIV-1 in human cervical carcinoma and endometrial carcinoma.


METHODS
RT-PCR was performed to detect the expression of LIV-1 mRNA in 49 cervical carcinoma, 11 normal cervical tissue, 24 endometrial carcinoma and 5 normal endometrial specimens.


RESULTS
The relative quantity of LIV-1 mRNA in normal cervical tissue, cervical carcinoma in situ and cervical carcinoma was 0.20-/+0.16, 0.31-/+0.13 and 0.40-/+0.15, respectively (P<0.05). No significant variation in LIV-1 mRNA expression was noted in relation to FIGO stages, histological differentiation, invasion depth and lymph node metastasis of the tumor (P>0.05), and LIV-1 mRNA level was similar between endometrial carcinoma and normal endometrial tissues (P>0.05).


CONCLUSIONS
LIV-1 mRNA upregulation seems to be tissue-specific, and LIV-1 can be associated with the progression of cervical squamous cell carcinoma progression but not with the development of endometrial carcinoma.
Zhao
Le
L
Center for Laboratory Medicine, First Affiliated Hospital of School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. zhaole@stu.xjtu.edu.cn
Chen
Wei
W
Li
Xu
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D027682:Cation Transport Proteins / Q000235:genetics* / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D027682:Cation Transport Proteins; D009363:Neoplasm Proteins; C418627:SLC39A6 protein, human