Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report.
Whether levels of fetal hemoglobin (HbF), a possible marker of antecedent hypoxemia, are increased in sudden infant death syndrome (SIDS) compared to controls is unresolved. Our aims are to: (1) Compare percent fetal hemoglobin (%HbF) levels in SIDS and control cases, and (2) compare our findings with those reported in previous studies. Using Triton-acid-urea gel electrophoresis and quantitative densitometry, %HbF was determined in whole blood specimens obtained at autopsy from SIDS and control cases accessioned into the San Diego SIDS/SUDC Research Project database. The SIDS and control cases were not different with respect to mean age, gender, gestational age, method of delivery, birth weight, or mean autopsy interval; %HbF levels in SIDS and control cases were not significantly different. Given that our results were obtained using optimal methods in well-defined SIDS and control cases, we concur with others that %HbF is not elevated in SIDS.
Krous
Henry F
HF
Rady Children's Hospital and Health Center, 3020 Children's Way, MC5007, San Diego, CA 92123, USA. hkrous@chsd.org
Haas
Elisabeth A
EA
Chadwick
Amy E
AE
Masoumi
Homeyra
H
Stanley
Christina
C
Perry
Gary W
GW
D015415:Biomarkers / Q000097:blood; D002140:California; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005319:Fetal Hemoglobin / Q000032:analysis*; D049429:Forensic Pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D013398:Sudden Infant Death / Q000097:blood*
D015415:Biomarkers; D005319:Fetal Hemoglobin