title: [Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system].
abstract: OBJECTIVE
  To study the acute toxicity of carbon-coated iron nanocrystal (CCIN) in mice and its effects on hepatic, renal and hematological functions.
  
  
  METHODS
  Acute toxicity of CCIN was evaluated by observing the toxic reactions in mice within 14 days following intravenous injection of different doses of CCIN particles. The liver and kidney functions and blood chemistry were tested in rats before and at different time points after CCIN injection.
  
  
  RESULTS
  The median lethal dose (LD(50)) of CCIN particles given by intravenous injection was 203.8 mg /kg in mice. Within the intravenous dose of 80 mg /kg injection, CCIN caused only mild alterations of the rats' biochemical and hematological indices that recovered without intervention in two weeks.
  
  
  CONCLUSIONS
  CCIN is characterized by low acute toxicity and mild side effects on the hepatic, renal and hematological functions within a certain dose range.
authors.affiliation: Department of Hepatobiliary Surgery, Cancer Center, Sun Yat-sen University & State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Lao
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Li
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Min-Shan
authors.initials: MS
authors.lastname: Chen
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Yuan
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D002244:Carbon / Q000633:toxicity*; D007501:Iron / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002244:Carbon; D007501:Iron