Evaluation of magnetic resonance imaging characteristics of new nitroxyl radicals on the model of RLS lymphoma.
Toxic and magnetic resonance contrast characteristics of new nitroxyl radicals Fur-135 and Fur-176 were studied in experiments on mice. The test compounds exhibited low toxicity and allowed us to increase contrasting of transplanted RLS lymphoma. Fur-135 differs by the type of contrasting from Gd(3+)-containing preparation omniscan and locates the tumor focus with high precision.
Letyagin
A Yu
AY
Laboratory of Medical Diagnosis, International Tomographic Center, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Sorokina
K N
KN
Tolstikova
T G
TG
Zhukova
N A
NA
Popova
N A
NA
Fursova
E Yu
EY
Savelov
A A
AA
Ovcharenko
V I
VI
D000818:Animals; D001921:Brain / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D005609:Free Radicals / Q000008:administration & dosage / Q000737:chemistry; D007275:Injections, Intravenous; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D009589:Nitrogen Oxides / Q000008:administration & dosage / Q000737:chemistry*; D015203:Reproducibility of Results; D013154:Spleen / Q000473:pathology
D003287:Contrast Media; D005609:Free Radicals; D009589:Nitrogen Oxides; C039900:nitroxyl