Rapid responses to aldosterone in the kidney and colon.
Aldosterone is a crucial modulator of ion transport across high resistance epithelia and regulates whole body electrolyte balance through its effects on the kidney and colon. The net consequence of aldosterone release is to promote salt conservation. The genomic mechanism of aldosterone action is relatively well characterized and the role of the classical mineralocorticoid receptor as a ligand-dependent transcription factor is well established. The rapid effects of aldosterone on target tissues are less well understood and there is still controversy over the identity of the aldosterone non-genomic receptor. Greater understanding of the physiological consequences of aldosterone's rapid responses in the kidney and colon has been achieved through the identification of definite and putative membrane targets and their signaling regulators.
Harvey
Brian J
BJ
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. bjpharvey@rcsi.ie
Alzamora
Rodrigo
R
Stubbs
Adam K
AK
Irnaten
Mustapha
M
McEneaney
Victoria
V
Thomas
Warren
W
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D020013:Calcium Signaling; D003106:Colon / Q000187:drug effects* / Q000502:physiology; D053503:Epithelial Sodium Channels / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D006180:Proton-Translocating ATPases / Q000502:physiology; D018161:Receptors, Mineralocorticoid / Q000502:physiology; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D013997:Time Factors
D053503:Epithelial Sodium Channels; D015221:Potassium Channels; D018161:Receptors, Mineralocorticoid; D017923:Sodium-Hydrogen Exchangers; D000450:Aldosterone; D011494:Protein Kinases; D006180:Proton-Translocating ATPases; D000254:Sodium-Potassium-Exchanging ATPase