title: Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses.
abstract: The chemical shift displacement error (CSDE) is an often-underestimated problem in slice selection for localized proton spectroscopy at higher fields. With the proposed semi-localized by adiabatic selective refocusing (LASER) pulse sequence, this problem is dealt with by using RF pulses with bandwidths in the order of 5 kHz. A combination of conventional nonadiabatic slice-selective excitation of proton spins, together with double slice-selective refocusing of the spins by two pairs of adiabatic full-passage (APF) pulses, produces a spin echo in a volume of interest (VOI) at an echo time down to 30 ms. An illustration of the CSDE of conventional point-resolved spectroscopy (PRESS) and the semi-LASER sequence is shown with a measurement of the brain of a volunteer at 3T. With one application of the technique to a patient with a glioblastoma multiforme (GBM), its clinical functionality is demonstrated. With sharp selection profiles and a small CSDE, voxels close to the edge of the VOI can also be used for evaluation. With the additional advantage of being relatively insensitive for B(1) inhomogeneities, the semi-LASER technique can be viewed as a superior substitute for conventional PRESS MR spectroscopic imaging (MRSI) at 3T and beyond.
authors.affiliation: Department of Radiology (667), University Medical Center Nijmegen, Nijmegen, The Netherlands. T.Scheenen@rad.umcn.nl
authors.forename: Tom W J
authors.initials: TW
authors.lastname: Scheenen
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
authors.forename: Jannie P
authors.initials: JP
authors.lastname: Wijnen
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*