title: [Are the antibodies against laminin-1 the signifikant marker of decreased fertility in women?].
abstract: OBJECTIVE
  Study of antibodies against laminin-1 in IgG in patients with habitual abortion.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Commercial ELISA method for detection of IgG antibodies against laminin-1 in ovulatory cervical mucus, in sera in women with repeated spontaneous abortions, in sera in patients during spontaneous miscarriages.
  
  
  RESULTS
  Positive levels of antibodies against laminine-1 in IgG in sera were found in patients during spontaneous abortions, as to ovulatory mucus of infertile women in time out of pregnancy, we did not find any positivity, only in one serum sample in patient with three pregnancy losses in her history.
  
  
  CONCLUSIONS
  Antibodies against adhesive molecule as laminin-1 presents, can participate during diagnosis of repated spontaneous miscarriages in context of neuro-endocrinne-immune dysregulation, which is not seen during physiological pregnancy.
authors.affiliation: Gynekologicko-porodnická klinika LF UK a FN Plzen.
authors.forename: J
authors.initials: J
authors.lastname: Gruberová
authors.forename: Z
authors.initials: Z
authors.lastname: Ulcová-Gallová
authors.forename: K
authors.initials: K
authors.lastname: Bibková
authors.forename: Z
authors.initials: Z
authors.lastname: Micanová
authors.forename: M
authors.initials: M
authors.lastname: Králícková
authors.forename: Z
authors.initials: Z
authors.lastname: Novotný
authors.forename: Z
authors.initials: Z
authors.lastname: Rokyta
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D000022:Abortion, Spontaneous / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002582:Cervix Mucus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007247:Infertility, Female / Q000175:diagnosis; D007797:Laminin / Q000276:immunology*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D007797:Laminin; C121346:laminin 1