[Serotonin and endotelin-1 expression in human thymus in aging].
The use of immunohistochemical method enabled to obtain for the first time the expression of two vasoactive hormones--serotonin and endothelin-1 in human thymus. The high level of the expression of these hormones has been shown in aging. Taking into account the immunoregulatory effects of serotonin and endothelin-1, and especially the activation of T-lymphocyte function under their influence, these data testify to the important role of these hormones in the regulation of immunity in aging.
Poliakova
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D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D019332:Endothelin-1 / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012701:Serotonin / Q000032:analysis / Q000378:metabolism*; D013950:Thymus Gland / Q000737:chemistry / Q000276:immunology*
D019332:Endothelin-1; D012701:Serotonin