Apoptosis of primary sensory neurons in GD1b-induced sensory ataxic neuropathy.
Experimental autoimmune sensory ataxic neuropathy was induced in three of six rabbits sensitized with GD1b ganglioside (GD1b-SAN). TUNEL assay was performed on sections of dorsal root ganglia in the cauda equina. The results showed the presence of TUNEL-positive neurons in all three rabbits affected with GD1b-SAN. In contrast, no such neurons were observed in any of the sections from the unaffected rabbits that had been inoculated with GD1b, rabbits inoculated with adjuvant alone or those without inoculation. These data support that an apoptotic mechanism is involved in the pathogenesis of GD1b-SAN.
Takada
Kazuo
K
Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan.
Shimizu
Jun
J
Kusunoki
Susumu
S
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001259:Ataxia / Q000473:pathology; D053148:Caspase 3 / Q000276:immunology; D061945:Caspase Inhibitors; D002420:Cauda Equina / Q000473:pathology; D005727:Ganglia, Spinal / Q000473:pathology; D005732:Gangliosides / Q000276:immunology*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D009444:Neuritis, Autoimmune, Experimental / Q000473:pathology*; D009475:Neurons, Afferent / Q000473:pathology*; D011817:Rabbits; D016707:Tissue Fixation
D061945:Caspase Inhibitors; D005732:Gangliosides; C033851:ganglioside, GD1b; D053148:Caspase 3