title: A multidrug-resistant (MDR) HIV type 1 infection in a homosexual man and identified source patient.
abstract: We report a case (IC) of multidrug-resistant (MDR) HIV-1 infection in which the identification of the source patient (S) was supported by phylogenetic analysis of the pol gene and by the similarity of env sequences. HIV isolates from IC and S were characterized as non-syncytium viruses: a X4 variant (R(11) E(26)) was identified in both cases according to the V3 loop sequence. The pol mutational profile of IC included multiple protease and reverse-transcriptase inhibitor mutations similar to those in S. The lamivudine/tenofovir/tipranavir/ritonavir/enfuvirtide association was effective for IC but not for S.
authors.affiliation: Clinic of Infectious Diseases, University of Bari, Bari, Italy. l.monno@clininf.uniba.it
authors.forename: Laura
authors.initials: L
authors.lastname: Monno
authors.forename: Grazia
authors.initials: G
authors.lastname: Punzi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Brindicci
authors.forename: Antonella
authors.initials: A
authors.lastname: Lagioia
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Ladisa
authors.forename: Annalisa
authors.initials: A
authors.lastname: Saracino
authors.forename: Maria
authors.initials: M
authors.lastname: Ingletti
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Angarano
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral; D015752:Genes, env; D015751:Genes, pol; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006716:Homosexuality; D006801:Humans; D008297:Male; D009154:Mutation; D010802:Phylogeny; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents