Rhodium-catalyzed reactions of dithiols and 1,4-bis(bromomethyl)benzenes leading to enantioenriched dithiaparacyclophanes.
We have achieved the first catalytic enantioselective synthesis of planar-chiral dithiaparacyclophanes by means of cationic rhodium(I)/(S)-BINAPHANE complex-catalyzed reactions of dithiols and 1,4-bis(bromomethyl)benzenes. The present method represents the first example of asymmetric synthesis of planar-chiral cyclophanes through catalytic enantioselective construction of the ansa chains.
Tanaka
Ken
K
Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. tanaka-k@cc.tuat.ac.jp
Hori
Tomoko
T
Osaka
Takuya
T
Noguchi
Keiichi
K
Hirano
Masao
M