title: [Two cases of advanced gastric cancer in which paclitaxel proved effective after resistance to docetaxel].
abstract: Docetaxel and paclitaxel are demonstrated to be effective for use as salvage therapy for advanced gastric cancer. Both drugs are taxane derivatives but there is only partial cross-resistance between them. For breast cancer and ovarian cancer, there have been several reports that showed docetaxel is effective for paclitaxel-resistant cancer, and vice versa. We experienced two cases of advanced gastric cancer effectively treated by sequential therapy of docetaxel and paclitaxel. One patient was a 43-year-old woman with a type 4 gastric carcinoma, and the other a 51-year-old woman who had suffered a recurrence of the gastric cancer after a total gastrectomy. At first, chemotherapy failed, so we chose docetaxel/high-dose 5-FU (HDFU) for the second-line therapy. After resistance to Docetaxel/HDFU, paclitaxel was effective for third-line treatment of both patients.
authors.affiliation: Dept. of Medical Oncology, KKR Sapporo Medical Center Tonan Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsushima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Abe
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Fumito
authors.initials: F
authors.lastname: Tamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mizushima
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Makino
authors.forename: Kae
authors.initials: K
authors.lastname: Oura
authors.forename: Kana
authors.initials: K
authors.lastname: Honda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Naohito
authors.initials: N
authors.lastname: Yoshizaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kondo
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000077143:Docetaxel; D019008:Drug Resistance, Neoplasm; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel; D005472:Fluorouracil