title: Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male.
abstract: We report a case of a 55-year-old male patient with breast carcinoma, who developed choroidal metastasis. The patient had undergone mastectomy for carcinoma of right breast, five years ago. The patient was advised close follow-up for the left eye, as he was already on tamoxifen therapy (started a month ago) for spinal metastasis. On last follow-up, a year later, the choroidal lesion had completely scarred, with no recurrences. Systemic hormonal therapy like tamoxifen given for the breast primary and other systemic metastases may cause regression of the choroidal metastasis, thereby avoiding ocular radiotherapy. Medline search revealed only one published case of regression of choroidal metastasis from a male breast primary, on tamoxifen therapy.
authors.affiliation: Department of Ophthalmic and Facial Plastic Surgery, Orbital Diseases and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd, Mumbai, India. debraj_shome@yahoo.com
authors.forename: Debraj
authors.initials: D
authors.lastname: Shome
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.forename: Darshana
authors.initials: D
authors.lastname: Gadgil
authors.forename: Sundaram
authors.initials: S
authors.lastname: Natarajan
authors.forename: Vandana
authors.initials: V
authors.lastname: Jain
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018567:Breast Neoplasms, Male / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D002830:Choroid Neoplasms / Q000188:drug therapy* / Q000556:secondary; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008408:Mastectomy; D008875:Middle Aged; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*; D041623:Tomography, Optical Coherence
chemical_list: D000970:Antineoplastic Agents; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen