Utility of QuantiFERON-TB Gold in-tube testing for latent TB infection in HIV-infected individuals.
METHODS
Urban inner city human immunodeficiency virus (HIV) clinic.


OBJECTIVE
To evaluate tuberculin skin testing (TST) and QuantiFERON-TB Gold (QFT-G) testing in an HIV-infected population relative to the presence of risk factors for latent tuberculosis infection (LTBI).


METHODS
Cross-sectional analysis of the response of a whole blood gamma interferon release assay to early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) antigens and TST relative to known risk factors for LTBI.


RESULTS
Of 207 subjects enrolled, four were excluded due to missing data and three specimens yielded discordant results. Ten specimens were indeterminate due to inadequate response to mitogen. All indeterminate results occurred in subjects with CD(4) counts <200 cells/mm(3). Eleven QFT-G results and 13 TST results were positive. The concordance between TST and QFT-G was poor (kappa 0.38). QFT-G results were more likely than TST to be associated with risk factors for LTBI.


CONCLUSIONS
QFT-G, but not TST, showed a statistically significant association between the number of risk factors for LTBI and a positive result (OR 1.6). QFT-G testing may be more useful than TST in individuals with HIV infection.
Jones
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Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA. sij2002@med.cornell.edu
de Gijsel
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Wallach
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Gurtman
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Sacks
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D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis*
D007371:Interferon-gamma