title: Gingival enlargement in Niemann-Pick disease: a coincidence or link? Report of a unique case.
abstract: A case of a 25-year-old man appearing with generalized gingival enlargement is reported here. Niemann-Pick disease (NPD) was provisionally diagnosed by histopathologic analysis of tissue excised by gingivectomy and later confirmed by quantitative enzyme assay. Correlation between clinical features and histopathologic and biochemical analysis enabled the diagnosis of NPD type C.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Goa Dental College and Hospital, Bambolim, Goa, India. sumeetkaisare@rediffmail.com
authors.forename: Sumeet
authors.initials: S
authors.lastname: Kaisare
mesh_terms: D000015:Abnormalities, Multiple; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D019214:Gingival Overgrowth / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005890:Gingivectomy; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging; D008439:Maxillary Diseases / Q000000981:diagnostic imaging; D052556:Niemann-Pick Disease, Type C / Q000150:complications*; D011859:Radiography; D012008:Recurrence; D015203:Reproducibility of Results; D013108:Sphingomyelin Phosphodiesterase / Q000032:analysis
chemical_list: C112980:acid sphingomyelinase-1; D013108:Sphingomyelin Phosphodiesterase