Radiological contrast media and pancreatic blood perfusion in anesthetized rats.
BACKGROUND
Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation.


OBJECTIVE
To evaluate the effects of an iso-osmolar (iodixanol, 290 mOsm/kg H2O) and a low-osmolar (iopromide, 660 mOsm/kg H2O) CM on total pancreatic and islet blood perfusion.


METHODS
Thiobutabarbital-anesthetized rats were injected with iodine equivalent doses (600 mg I/kg body weight) of iodixanol or iopromide. Saline or low-osmolar mannitol (660 mOsm/kg H2O) solutions served as control substances. Blood perfusion measurements were then carried out with a microsphere technique.


RESULTS
Iso-osmolar iodixanol had no effects on blood perfusion. Low-osmolar iopromide increased total pancreatic blood perfusion, whereas islet blood perfusion was unchanged. No differences were seen when mannitol solutions were given.


CONCLUSIONS
Neither an iso-osmolar nor a low-osmolar CM affected pancreatic islet blood perfusion, whereas the low-osmolar CM increased total pancreatic blood perfusion. The absence of hemodynamic effect of low-osmolar mannitol suggests that the hyperosmolality per se of iopromide versus iodixanol does not induce the hemodynamic effect. The consequences of the effect of iopromide for pancreatic function remain to be established.
Linder
G
G
Carlsson
P O
PO
Källskog
Ö
Ö
Hansell
P
P
Jansson
L
L
Riesenfeld Källskog
V
V
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008863:Microspheres; D010179:Pancreas / Q000098:blood supply* / Q000000981:diagnostic imaging*; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000494:pharmacology*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C044834:iodixanol