Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation.
Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel expressed in most central neurons, where it exists as a highly phosphorylated protein. Kv2.1 plays a critical role in homoeostatic regulation of intrinsic neuronal excitability through its activity- and calcineurin-dependent dephosphorylation. Here, we review studies leading to the identification and functional characterization of in vivo Kv2.1 phosphorylation sites, a subset of which contribute to graded modulation of voltage-dependent gating. These findings show that distinct developmental-, cell- and state-specific regulation of phosphorylation at specific sites confers a diversity of functions on Kv2.1 that is critical to its role as a regulator of intrinsic neuronal excitability.
Mohapatra
D P
DP
Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, U.S.A.
Park
K-S
KS
Trimmer
J S
JS
D002460:Cell Line; D006801:Humans; D015640:Ion Channel Gating; D009474:Neurons / Q000502:physiology; D010766:Phosphorylation; D051669:Shab Potassium Channels / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D053719:Tandem Mass Spectrometry
D051669:Shab Potassium Channels