title: Development of strategies for the regiocontrolled synthesis of meso-5,10,20-triaryl-2,3-chlorins.
abstract: Triglycoconjugated photosensitizers show promise for use in the photodynamic therapy-based treatment of cancer. Two different routes have been studied for the regioselective preparation of 5,10,20-meso-triphenyl-2,3-chlorin, 9a, and 5,10,20-meso-tri(4-isopropyloxyphenyl)-2,3-chlorin, 9b. The main issue was to control the placement of the partially reduced pyrrole ring in the more hindered environment in the triarylchlorin products.
authors.affiliation: UMR 176 CNRS/Institut Curie, Institut Curie, Bât. 110, Centre Universitaire, Université Paris-Sud XI, Orsay, France.
authors.forename: Marilyne
authors.initials: M
authors.lastname: Varamo
authors.forename: Bernard
authors.initials: B
authors.lastname: Loock
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: David S
authors.initials: DS
authors.lastname: Grierson
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000737:chemistry; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005960:Glucosides; D011166:Porphyrins; C006969:chlorin