Lifespan regulation of conventional protein kinase C isotypes.
Plasma membrane translocation, following allosteric binding of second messengers, initiates the signal transduction process mediated by cPKC [conventional PKC (protein kinase C)] isotypes. Mechanisms regulating the lifespan of the active enzyme such as its phosphorylation, internalization, dephosphorylation and degradation are key elements of the signalling network. The understanding of such mechanisms is essential for the design of therapeutic strategies targeting PKC isoenzymes.
Carmena
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D
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, U.K.
Sardini
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A
D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D006868:Hydrolysis; D007527:Isoenzymes / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D015290:Second Messenger Systems
D007527:Isoenzymes; D011493:Protein Kinase C