title: [Human pituitary embryonic morphogenesis].
abstract: Basic stages of pituitary gland organogenesis were studied using the methods of light microscopy in human embryos at Carnegie stages (CS) 12-23 (25-57 postovulatory days). It is shown that Rathke's pouch (RP) is formed like a traction fold along the whole width of the stomodeum roof in embryos at CS 12 as a result of a neural tube bend, to which the epithelium is closely connected anatomically (attached part of RP front wall) in the middle plane of the embryo. At CS 15 the primordia of hypothalamic infundibulum and of neurohypophysis are formed as a thickening of diencephalic posterior wall. At CS 20-23 transorientation of brain components, including hypophyseal primordium, takes place. After that the attached part of RP front wall forms pars intermedia and pars tuberalis of the pituitary, and the epithelium of RP orifice and that of its posterior wall forms pars distalis. During CS 20-23, structural-functional units of adenohypophysis--epithelial cords--are formed due to invagination of RP epithelium.
authors.forename: G S
authors.initials: GS
authors.lastname: Solov'ev
authors.forename: A V
authors.initials: AV
authors.lastname: Bogdanov
authors.forename: S M
authors.initials: SM
authors.lastname: Panteleev
authors.forename: V L
authors.initials: VL
authors.lastname: Ianin
mesh_terms: D006801:Humans; D038081:Organogenesis; D010902:Pituitary Gland / Q000196:embryology*