Polymer assisted hydroxyapatite microspheres suitable for biomedical application.
Hollow Microspheres of hydroxyapatite-polymer composite can be used as carriers in drug delivery and fillers in tissue engineering. Based on the concept of soft chemistry, a battery of technique is available in the literature to synthesize hollow microspheres, however, an economically viable synthesis route, having good control over the microarchitect and easy to be scaled up, is yet to be developed. Polymer matrix mediated synthesis of inorganic nanoparticles is known to synthesize nanoparticles with controlled morphology and dimensions. It is termed as biomimetic synthesis. Integrating the biomimetic synthesis of nano-particles and spray drying techniques, a novel process of producing hydroxyapatite-polymer composite hollow microspheres is briefly discussed here.
Sinha
A
A
Materials Science & Technology Division, National Metallurgical Laboratory, Jamshedpur 831007, India. arvind@nmlindia.org
Mishra
T
T
Ravishankar
N
N
D001672:Biocompatible Materials; D018786:Bone Substitutes; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000295:instrumentation*; D017886:Durapatite / Q000737:chemistry*; D004867:Equipment Design; D007700:Kinetics; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053758:Nanoparticles; D011108:Polymers; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation*
D001672:Biocompatible Materials; D018786:Bone Substitutes; D011108:Polymers; D017886:Durapatite