Targeting V(D)J recombinase: putting a PHD to work.
In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H3K4 trimethylation. Because this mark associates with active promoters, the finding forges a new link between transcription, epigenetics, and recombinase targeting during lymphocyte development.
Oltz
Eugene M
EM
Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232, USA. eugene.oltz@vanderbilt.edu
Osipovich
Oleg
O
D000818:Animals; D044127:Epigenesis, Genetic; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D005803:Genes, Immunoglobulin; D006801:Humans; D008214:Lymphocytes; D008957:Models, Genetic; D018448:Models, Immunological; D014158:Transcription, Genetic; D045567:VDJ Recombinases / Q000378:metabolism*
D045567:VDJ Recombinases