title: Cardiac Fabry's disease: an unusual cause of left ventricular hypertrophy.
abstract: BACKGROUND
  A 64-year-old male was observed as an outpatient with atypical, non-exercise-induced chest pain and palpitations. He had arterial hypertension and marked concentric left ventricular hypertrophy. After 2.5 years of antihypertensive drug therapy the patient's blood pressure had returned to normal, but his left ventricular hypertrophy was unchanged.
  
  
  METHODS
  Electrocardiography, transthoracic echocardiography, myocardial perfusion scintigraphic imaging, measurement of alpha-galactosidase A activity, gene sequencing, brain MRI, carotid artery ultrasonography, biochemical renal evaluation and cardiac Doppler tissue imaging.
  
  
  METHODS
  Cardiac Fabry's disease.
  
  
  RESULTS
  Losartan, hydrochlorothiazide, low-dose aspirin and bisoprolol. The patient is expected to begin enzyme replacement therapy.
authors.affiliation: Faculdade de Medicina do Porto, Alameda Prof Hernâni Monteiro, 4200 Porto, Portugal. jplnunes@med.up.pt
authors.forename: José Pedro L
authors.initials: JP
authors.lastname: Nunes
authors.forename: Ovídio
authors.initials: O
authors.lastname: Costa
authors.forename: Maria do Sameiro
authors.initials: Mdo S
authors.lastname: Faria
authors.forename: Pedro Bernardo
authors.initials: PB
authors.lastname: Almeida
authors.forename: Lúcia
authors.initials: L
authors.lastname: Lacerda
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D057487:Enzyme Therapy; D000795:Fabry Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D000519:alpha-Galactosidase / Q000097:blood / Q000627:therapeutic use
chemical_list: D002317:Cardiovascular Agents; D000519:alpha-Galactosidase