title: Parecoxib sodium administered over several days reduces pain after gynecologic surgery via laparotomy.
abstract: OBJECTIVE
  To assess the analgesic efficacy of a multidose, multiday regimen of intravenous (IV) parecoxib sodium (parecoxib).
  
  
  METHODS
  Multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.
  
  
  METHODS
  Postoperative recovery area and inpatient care facility.
  
  
  METHODS
  422 patients who had undergone gynecologic surgery via laparotomy participated (day 1), and 414 patients were randomized (day 2).
  
  
  METHODS
  After surgery on day 1, all patients received parecoxib 40 mg (IV), followed by 20 mg (IV) one to 12 hours later; patients were then randomized to receive parecoxib 20 mg (IV) twice daily (n = 211) or placebo (IV) twice daily (n = 203) on days 2 to 5. Patients were permitted rescue medication as needed.
  
  
  METHODS
  Primary efficacy measures were summed pain intensity through 24 hours (SPI-24) and Patient's Global Evaluation of Study Medication on days 2 and 3.
  
  
  RESULTS
  In the parecoxib treatment group, 24-hour summed pain intensity scores were significantly lower than in the placebo treatment group (P < 0.001) on days 2 and 3. More patients in the parecoxib treatment group rated their treatment as "excellent" or "good" using the Patient's Global Evaluation of Study Medication (P < 0.001) on days 2 and 3. Patients treated with parecoxib had lower pain intensity and consumed less rescue medication compared with the placebo-treated patients.
  
  
  CONCLUSIONS
  Multidose parecoxib was well tolerated over several days and provided improved pain control after gynecologic surgery.
authors.affiliation: Pfizer Global Research and Development, Skokie, IL, USA. mcsnabes@comcast.net
authors.forename: Michael C
authors.initials: MC
authors.lastname: Snabes
authors.forename: Artur J
authors.initials: AJ
authors.lastname: Jakimiuk
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Katz
authors.forename: Mark T
authors.initials: MT
authors.lastname: Brown
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Verburg
mesh_terms: D000328:Adult; D000368:Aged; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage*; D007813:Laparotomy; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; C409945:parecoxib