A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution.
The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.
Tjosaas
Freddy
F
Department of Chemistry, Norwegian University of Science and Technology, NTNU N-7491 Trondheim, Norway. tjosas@chem.ntnu.no
Fiksdahl
Anne
A
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007539:Isonicotinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D002264:Carboxylic Acids; D007539:Isonicotinic Acids; D011725:Pyridines; C525262:methyl 3-fluoropyridine-4-carboxylate