Adipose tissue metabolism -- an aspect we should not neglect?
Free fatty acids (FFAs) are the most metabolically important products of adipose tissue lipolysis. Experimentally creating high FFA concentrations can reproduce the metabolic abnormalities of obesity in lean, healthy persons and lowering FFA concentrations can improve the metabolic health of upper body obese individuals. FFA concentrations are determined by both the release of FFAs into the bloodstream and the clearance of FFAs from the bloodstream. Normal FFA release rates are different in men and women and total FFA release is closely linked to resting energy expenditure. Upper body subcutaneous fat, visceral fat, and leg fat depots contribute differently to the exposure of various tissues to FFAs. The implications of regional adipose tissue lipolysis to systemic FFA availability and the effect of different approaches to treatment of obesity are discussed.
Jensen
M D
MD
Endocrine Research Unit, Mayo Clinic, Rochester, M55905, USA. jensen.michael@mayo.edu
D000273:Adipose Tissue / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified