Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma--results from the ALA-ACRC low-dose theophylline trial.
In a study comparing low-dose theophylline to montelukast in poorly controlled asthmatics, 285 subjects consented to be screened for alpha-1 antitrypsin deficiency. Of the 284 for which complete data was available, 10.5% carried a deficiency gene and 2.4% were mildly deficient with an alpha-1 antitrypsin serum level of less than 20 mu M. In the non-African-American cohort, an abnormal phenotype occurred in 12% and 2.9% were mildly deficient. Baseline pulmonary function and asthma scores were not significantly different between those with normal and abnormal AAT phenotype. However those with the deficiency tended to show a greater bronchodilator response.
Eden
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Division of Pulmonary & Critical Care Medicine, St. Luke's Roosevelt Hospitals, Columbia University, New York, New York 10025, USA. ee5@columbia.edu
Holbrook
J T
JT
Brantly
M L
ML
Turino
G M
GM
Wise
R A
RA
D000085:Acetates / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003521:Cyclopropanes; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D011804:Quinolines / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D013440:Sulfides; D013806:Theophylline / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications / Q000453:epidemiology* / Q000235:genetics
D000085:Acetates; D001993:Bronchodilator Agents; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D013806:Theophylline; C093875:montelukast