title: pH in nasal exhaled breath condensate in healthy adults.
abstract: This paper describes a new method to assess nasal pH in nasal exhaled breath condensate in adults. The study included 19 healthy, non-smoking, adult volunteers without current upper respiratory disease, COPD or asthma. Expiratory breath condensate (EBC) was collected from the nose and mouth respectively. A Jaeger breath condenser was fitted with a transparent facemask and during oral sampling it was fitted with a mouthpiece. The condensates were bubbled with argon gas for 10 minutes to reduce carbon dioxide and the samples were analysed immediately using a calibrated glass electrode and a portable pH-meter. The mean pH in the nasal EBC was 7.0 +/- 0.5 and in oral EBC 6.9 +/- 0.7 (p = 0.6). The nasal EBC-pH was well in agreement with data from previous studies, which measured pH directly on the nasal mucosa with an electrode. In conclusion, this paper describes a method to measure pH in nasal exhaled breath condensate (EBC) in healthy adults during tidal breathing. The nasal EBC-pH related well to previous data from intranasal pH measurements suggesting that nasal EBC-pH could have a role in monitoring pH alterations in the nasal mucosa such as nasal inflammation.
authors.affiliation: Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: Sophie
authors.initials: S
authors.lastname: Svensson
authors.forename: Johan
authors.initials: J
authors.lastname: Hellgren
mesh_terms: D000328:Adult; D001944:Breath Tests; D045853:Exhalation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry; D013048:Specimen Handling