The relationship between IL-1 gene polymorphism and marginal bone loss around dental implants.
OBJECTIVE
Early marginal bone loss around dental implants has been found during the bone healing period before stage II surgery despite a lack of apparent cause, and the etiology of this bone loss is unclear. This study was designed to investigate whether interleukin-1 gene polymorphism is associated with the marginal bone loss around the implants before stage II.


METHODS
One hundred forty-three implants were placed in 59 patients. The patients were divided into 2 groups: 1) test group: with 1 or more marginal bone loss greater than 0.5 mm; and 2) control group: with marginal bone resorption less than 0.5 mm. Polymorphisms of the IL-1alpha and IL-1beta genes (IL-1A-889, IL-1B-511, and IL-1B+3954) were detected by restriction fragment length polymorphism using Ncol, AvaI, and TaqI digestion after polymerase chain reactions.


RESULTS
The frequency of IL-1B-511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (-) group (P < .05). Multiple logistic regressions showed the OR of the II/II versus the I/I+I/II of the IL-1B-511 genotype was 3.933 between the 2 groups. The difference was statistically significant (P < .05). There was no significant difference between the other risk factors.


CONCLUSIONS
These results suggest that the IL-1B-511 II/II genotype in individuals is associated with early marginal bone loss around implants.
Lin
Ying-He
YH
Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
Huang
Ping
P
Lu
Xuan
X
Guan
Dong-Hua
DH
Man
Yi
Y
Wei
Na
N
Wang
Yong-Yue
YY
Gong
Ping
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D015921:Dental Implants; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011862:Radiography, Panoramic; D012907:Smoking
D015921:Dental Implants; D007375:Interleukin-1; D053582:Interleukin-1alpha; D053583:Interleukin-1beta