title: Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular catalysts.
abstract: Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols and is now is applicable to commercial scale production.
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Ikariya
authors.forename: A John
authors.initials: AJ
authors.lastname: Blacker
mesh_terms: D002384:Catalysis; D002617:Chemical Industry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D007659:Ketones; D019216:Metals, Heavy