title: Age-related changes of elements in human corpus callosum and relationships among these elements.
abstract: To elucidate compositional changes of the corpus callosum with aging, the authors investigated age-related changes of elements and relationships with their element contents in the corpus callosum. After ordinary dissection by medical students at Nara Medical University was finished, the genu, trunk, and splenium of the corpus callosum were resected from the subjects ranging in age from 58 to 94 years. The element contents of the corpus callosum were determined by inductively coupled plasma-atomic emission spectrometry. The contents of Ca, P, S, Mg, Zn, Fe, and Na did not change significantly in the genu, trunk, and splenium of the corpus callosum with aging. Regarding the relationships among the element contents, significant correlations were found among the contents of Ca, P, S, Mg, and Fe in all of the genu, trunk, and splenium of the corpus callosum with some exceptions.
authors.affiliation: Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan.
authors.forename: Setsuko
authors.initials: S
authors.lastname: Tohno
authors.forename: Cho
authors.initials: C
authors.lastname: Azuma
authors.forename: Nutcharin
authors.initials: N
authors.lastname: Ongkana
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tohno
authors.forename: Pasuk
authors.initials: P
authors.lastname: Mahakkanukrauh
authors.forename: Yumi
authors.initials: Y
authors.lastname: Moriwake
authors.forename: Atsuko
authors.initials: A
authors.lastname: Izu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Minami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003337:Corpus Callosum / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals / Q000378:metabolism*; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D044967:Serum / Q000378:metabolism*
chemical_list: D008670:Metals; D010758:Phosphorus