CSF proteomic fingerprints for HIV-associated cognitive impairment.
Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.
Laspiur
Juliana Pérez
JP
Specialized Neurosciences Research Program, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Anderson
Eric R
ER
Ciborowski
Pawel
P
Wojna
Valerie
V
Rozek
Wojciech
W
Duan
Fenghai
F
Mayo
Raul
R
Rodríguez
Elaine
E
Plaud-Valentín
Marinés
M
Rodríguez-Orengo
José
J
Gendelman
Howard E
HE
Meléndez
Loyda M
LM
D000328:Adult; D002555:Cerebrospinal Fluid / Q000378:metabolism* / Q000821:virology*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology*; D015331:Cohort Studies; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D008969:Molecular Sequence Data; D009483:Neuropsychological Tests; D040901:Proteomics; D019562:Viral Load / Q000379:methods