title: Two new metabolites with cytotoxicities from deep-sea fungus, Aspergillus sydowi YH11-2.
abstract: Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3- dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.
authors.affiliation: Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P. R. China.
authors.forename: De-Hai
authors.initials: DH
authors.lastname: Li
authors.forename: Sheng-Xin
authors.initials: SX
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Zhen-Jian
authors.initials: ZJ
authors.lastname: Lin
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Liu
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012623:Seawater / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents