title: Advances in stereotactic radiosurgery in the treatment of pituitary adenomas.
abstract: OBJECTIVE
  Stereotactic radiosurgery has become the preferred radiation treatment modality for secreting and nonsecreting pituitary adenomas, although randomized studies comparing delivery systems, fractionation and dose have not been performed.
  
  
  RESULTS
  The technical achievement of radiosurgery delivery systems has minimized the radiation dose to surrounding normal tissue compared with external beam radiotherapy. With a reduction in acute and chronic side effects, the total dose to abnormal tissue can be increased allowing for greater tumor control.
  
  
  CONCLUSIONS
  The radiobiology, control rates and normal tissue tolerances of stereotactic radiosurgery in the treatment of pituitary adenomas is reviewed.
authors.affiliation: Neurological Surgery, Swedish Neuroscience Institute, Seattle, Washington 98122, USA. Marc.Mayberg@swedish.org
authors.forename: Marc
authors.initials: M
authors.lastname: Mayberg
authors.forename: Sandra
authors.initials: S
authors.lastname: Vermeulen
mesh_terms: D000172:Acromegaly / Q000532:radiotherapy / Q000601:surgery; D000236:Adenoma / Q000601:surgery* / Q000628:therapy; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000532:radiotherapy / Q000601:surgery; D010911:Pituitary Neoplasms / Q000601:surgery* / Q000628:therapy; D015175:Prolactinoma / Q000601:surgery / Q000628:therapy; D016634:Radiosurgery