Characterization of mouse brain and its development using diffusion tensor imaging and computational techniques.
Diffusion tensor magnetic resonance imaging (DTI) was used to study mouse brain development from early embryonic stage to adult. DTI provides necessary resolution and superb white matter and gray matter contrast in embryonic and neonatal brains for characterization of morphological changes during mouse brain development. A database and a digital atlas of developing mouse brains based on our DTI results are being constructed. To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database.
Zhang
Jiangyang
J
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA. jzhang3@jhmi.edu
Richards
Linda J
LJ
Miller
Michael I
MI
Yarowsky
Paul
P
van Zijl
Peter
P
Mori
Susumu
S
D000328:Adult; D000375:Aging / Q000473:pathology / Q000502:physiology; D000465:Algorithms; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000196:embryology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging*; D009474:Neurons / Q000166:cytology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography