[Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi].
Scutellaria baicalensis Georgi (S. baicalensis) is a widely used herb in traditional medical systems of China and Japan. The major constituents of S. baicalensis are flavonoids: baicalein, baicalin, wogonin, which have been associated with various properties, for example: antioxidant, anti-inflammatory, antithrombotic, antibacterial, antiviral. Atherosclerosis is a multiple factors disease, in which the main roles play oxidant stress, endothelium dysfunction and disorders ofhemostasis. It is supposed that flavonoids from S. baicalensis roots in the nearest future could be use in the primary and secondary prevention of atherosclerosis.
Broncel
Marlena
M
Kliniki Chorób Wewnetrznych z Oddziałem Farmakologii Klinicznej i Terapii Monitorowanej Uniwersytetu Medycznego w Lodzi. ttm@ttm.org.pl
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy* / Q000517:prevention & control; D002681:China; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D031364:Scutellaria baicalensis / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D047309:Flavones; D005419:Flavonoids; D016166:Free Radical Scavengers; C038044:baicalin; C006680:baicalein; C085514:wogonin