Getting a G--RRP on regulated exocytosis in the heart.
A study by Rybkin et al. (see p. 527) substantially advances our understanding of regulated exocytois by specialized secretory cells, such as atrial myocytes. A second member of the Ras-related protein family, RRP17, was identified and shown to participate in regulating the secretion of the cardiac-derived peptide hormone, atrial natriuretic peptide. In addition to the heart, RRP17 was shown to be expressed in neuronal, pancreatic, and skeletal muscle cells, suggesting a widespread role in regulated secretion for this new protein.
Glembotski
Christopher C
CC
Department of Biology, The SDSU Heart Institute and San Diego State University, San Diego, CA 92182, USA. cglembotski@sciences.sdsu.edu
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000502:physiology; D005089:Exocytosis; D006325:Heart Atria / Q000378:metabolism* / Q000473:pathology*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D032342:Muscle Cells / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D018631:ras Proteins / Q000096:biosynthesis* / Q000502:physiology*
D006728:Hormones; D010455:Peptides; C524797:RRP17 protein, human; D009320:Atrial Natriuretic Factor; D018631:ras Proteins