Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction.
An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alpha-exo-methylene indanones depending on the base used.
Minatti
Ana
A
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Zheng
Xiaolai
X
Buchwald
Stephen L
SL
D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis*; D008024:Ligands; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*
D007189:Indans; D008024:Ligands; D010165:Palladium