[Application of entropy-based complex systems partition method in research on quantizing TCM syndrome diagnostic criteria of angina pectoris].
OBJECTIVE
To establish the quantized criteria for TCM syndrome diagnosis of angina pectoris (AP) using the entropy-based complex systems partition method (EBCSPM).


METHODS
Four hundred and three AP patients were randomly assigned to two groups: the operation group (302 cases) and the examination group (101 cases). The symptomatic information of the patients was extracted using EBCSPM to make sure the contribution degree of each symptom to syndrome diagnosis, and the diagnostic threshold was established by the analysis of receiver operating characteristic curves (ROC).


RESULTS
The basic syndromes manifested during AP were collateral-qi stagnation, collateral-qi deficiency and stagnation, turbid phlegm, blood stasis, phlegm-heat, heat-fire, yin deficiency and yang deficiency, etc. Different symptoms contributed to syndrome diagnosis to different degrees and with different diagnostic thresholds, showing good sensitivity and specificity in the prospective verification on the 101 patients in the examination group.


CONCLUSIONS
EBCSPM is applicable for quantizing TCM diagnostic criteria, and the established criteria shows favorable diagnostic efficacy for TCM syndrome diagnosis of AP.
Jia
Zhen-Hua
ZH
Medical Department, Yiling Hospital, Hebei Medical University, Shijiazhuang. jiatcm@163.com
Li
Ye-Shuang
YS
Wu
Yi-Ling
YL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D001330:Electronic Data Processing; D019277:Entropy; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D012107:Research Design; D012680:Sensitivity and Specificity; D013577:Syndrome