Declining mortality from bladder cancer in Europe.
OBJECTIVE
To update trends in bladder cancer mortality in 32 European countries and the European Union (EU) as a whole, as mortality from bladder cancer has been declining in most of Western Europe since the early 1990 s, but it has still been increasing in several central and eastern European countries up to the mid 1990 s.


METHODS
We used data from the World Health Organization (WHO) database over the period 1970-2004. Significant changes in mortality rates were identified using join-point regression analysis.


RESULTS
In the EU overall (27 countries), bladder cancer mortality rates (age-standardized, world standard population) were stable up to the early 1990 s at approximately 7/100,000 men and 1.5/100,000 women, and declined thereafter by approximately 16% in men and 12% in women, to reach values of 6 and 1.3/100,000, respectively, in the early years of the present decade. Over recent years, most countries showed decreasing trends, except Croatia and Poland in both sexes, Romania in men and Denmark in women. Truncated rates at age 35-64 years were lower in both sexes and trends for men were more favourable, with an overall decrease by >21% during the last decade. Join point regression analysis indicates that, for most countries, the trends were more favourable over recent calendar periods.


CONCLUSIONS
The favourable trends in men are partly or largely due to the recent declines in the prevalence of smoking in European men, together with reduced occupational exposure to occupational carcinogens. The decreases in women are more difficult to explain. Better control of urinary tract infections has probably played a role, while the role of diet and other potential urinary tract carcinogens remains undefined.
Ferlay
Jacques
J
International Agency for Research on Cancer, Lyon Cedex, France.
Randi
Giorgia
G
Bosetti
Cristina
C
Levi
Fabio
F
Negri
Eva
E
Boyle
Peter
P
La Vecchia
Carlo
C
D000328:Adult; D017677:Age Distribution; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D016273:Occupational Exposure / Q000009:adverse effects; D012044:Regression Analysis; D012907:Smoking / Q000009:adverse effects / Q000401:mortality / Q000639:trends; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000401:mortality*