title: [Study on the correlation of human influenza A/H3N2 hemagglutinin gene variation and the epidemic from 1995 to 2005 in China].
abstract: To study the correlation of human influenza A/H3N2 hemagglutinin gene variation and the epidemic from 1995 to 2005 in China, 550 HA1 sequences of H3N2 viruses isolated in China were analyzed with phylogenetic tree. The results showed that the evolution of HA1 represented a long trunk with short side branches. The animo acid changes of HA1 mostly located at the antigenic sites or aside of them, but also may occur at the other sites simultaneously. The analysis also showed three possibilities of HA1 variation to cause H3N2 epidemic, the first is multiple site mutations happened simultaneously; the second is mutation sites happened gradually and then accumulated to multiple sites; the third is a single antigenic site mutation occurred simultaneously with the receptor binding site variation.
authors.affiliation: Chinese Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China. donglibo8@126.com
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Dong
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Le-Ying
authors.initials: LY
authors.lastname: Wen
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Guo
authors.forename: Zi
authors.initials: Z
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Yuan-Ji
authors.initials: YJ
authors.lastname: Guo
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Shu
mesh_terms: D002681:China; D004196:Disease Outbreaks; D005814:Genes, Viral; D014644:Genetic Variation; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology*; D009154:Mutation; D013997:Time Factors
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus