title: Cardio-ankle vascular index is a new noninvasive parameter of arterial stiffness.
abstract: BACKGROUND
  Beta is an index of arterial stiffness independent of blood pressure. Beta of the thoracic descending aorta (TDA) has been obtained by transesophageal echocardiography (TEE) and the cardio-ankle vascular index (CAVI) is a new noninvasive estimation of beta.
  
  
  RESULTS
  The purpose of this study was to evaluate the accuracy and usefulness of CAVI and to compare it with other parameters of arteriosclerosis by carotid ultrasound (CU). The instantaneous dimensional change of the TDA on TEE was measured simultaneously with systemic pressure of the brachial artery in 70 patients in sinus rhythm. There were significant correlations between CAVI and age (r=0.65, p<0.01), and CAVI and the beta from TEE (Aobeta) (r=0.67, p<0.01). Next, 110 patients with chest pain syndrome underwent CU and measurement of CAVI, intima - media thickness (IMT), plaque score and beta. There were significant relationships between CAVI and IMT (r=0.42, p<0.01), and between CAVI and beta (r=0.39, p<0.01). CAVI of the group diagnosed with plaque was significant higher than that of the normal group (9.872+/-1.464 vs 9.038+/-1.377, p=0.0039).
  
  
  CONCLUSIONS
  CAVI is measured easily and noninvasively and is a new index of arterial stiffness that is independent of blood pressure.
authors.affiliation: Division of Cardiology, Tokuyama Central Hospital, Shunan, Japan. atakaki@cotton.ocn.ne.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Takaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Wakeyama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iwami
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kimura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hadano
authors.forename: Susumu
authors.initials: S
authors.lastname: Matsuda
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiratsuka
authors.forename: Masunori
authors.initials: M
authors.lastname: Matsuzaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000098:blood supply; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D050197:Atherosclerosis / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017548:Echocardiography, Transesophageal; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D018084:Ultrasonography, Interventional
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol