title: Biocompatibility of candidate materials for the realization of medical microdevices.
abstract: The propulsion of ferromagnetic micro-carriers in the blood vessels by magnetic gradients generated from a Magnetic Resonance Imaging (MRI) system is of special interest for targeted interventions such as chemotherapy or chemo-embolization. As such, Fe-Co alloys for its highest magnetization saturation, and single crystal Ni-Mn-Ga powder and Terfenol-D for their deformation in magnetic field are evaluated for their biocompatibility. The toxicity of these materials is evaluated with MTT cell viability tests. The tests show that Fe-Co (Permendur and Vacoflux 17) alloys are toxic within 24 hours while the single crystal Ni-Mn-Ga powder becomes toxic after 48 hours. The Terfenol-D, despite its high degradation, has 90% cell viability after 72 hours. These results indicate that such candidate materials to be considered in untethered micro-carriers or devices in the blood vessels would require, depending upon the time spent in the blood vessels, further processes to be viable for such applications.
authors.affiliation: Laboratory for the Innovation and Analysis of the Bioperformance, Ecole Polytechnique de Montreal, Department of Computer Engineering, Institute of Biomedical Engineering, Québec, Canada. pierre.pouponneau@polymtl.ca
authors.forename: Pierre
authors.initials: P
authors.lastname: Pouponneau
authors.forename: L'Hocine
authors.initials: L
authors.lastname: Yahia
authors.forename: Yahye
authors.initials: Y
authors.lastname: Merhi
authors.forename: Laura Mery
authors.initials: LM
authors.lastname: Epure
authors.forename: Sylvain
authors.initials: S
authors.lastname: Martel
mesh_terms: D000497:Alloys / Q000009:adverse effects*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D008422:Materials Testing; D051379:Mice; D008904:Miniaturization; D019736:Prostheses and Implants
chemical_list: D000497:Alloys; D001672:Biocompatible Materials