title: On the sneeze-reflex and its control.
abstract: Experiments in cats have shown that sneezing can be induced using low intensity electrical current. This study focusses on answering the question whether the sneezing-reflex can also be induced in man through electrical stimulation, whether it is reproducible, and if the response can be abolished pharmacologically? Three healthy males were tested using intranasal stimulation in different parts of the nose using a current from an electric pulse generator. Using currents in the range 2-11 mA, it was possible to induce and reproduce sneezing in the anterior portion of the nose corresponding to the distribution area of the anterior ethmoidal nerve. In one tested subject, local anaesthetics applied to the mucous membranes of the nose abolished the sneezing. Sneeze reflex-reduction may be one way to reduce viral contamination between subjects. Further research could include pharmacological investigations to identify a sneeze-inhibiting substance with small risks for side effects that can be added to common cold nasal sprays.
authors.affiliation: Department of Otorhinolaryngology, University Hospital, SE-58185 Linköping, Sweden. dag.hyden@lio.se
authors.forename: Dag
authors.initials: D
authors.lastname: Hydén
authors.forename: Stig
authors.initials: S
authors.lastname: Arlinger
mesh_terms: D000328:Adult; D004558:Electric Stimulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000502:physiology*; D012912:Sneezing / Q000502:physiology*