title: [Study on parental origin of complete hydatidiform mole detected by polymorphisms of microsatellite].
abstract: OBJECTIVE
  Through detection of 9 loci of polymorphisms of microsatellite to investigate the parental origin of complete hydatidiform mole.
  
  
  METHODS
  Using the technology and method of multipolymerase chain reaction and electrophoresis in denatured polyacrylamide gel and silver stain detection, we carried out DNA analysis on 50 cases of complete hydatidiform mole diagnosed by histopathology and 50 copies of the couples' peripheral blood.
  
  
  RESULTS
  There are 7 cases of biparental complete hydatidiform mole (14%); and 43 cases of androgenetic complete hydatidiform mole (86%) among 50 cases of complete hydatidiform mole.
  
  
  CONCLUSIONS
  Detection of polymorphisms of microsatellite is a technology that can be used to identify the parental origin of complete hydatidiform mole. It is simple, quick, reliable and highly efficient.
authors.affiliation: Department of Gynecological Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Shun-sheng
authors.initials: SS
authors.lastname: Deng
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Ding
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Qian
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Lü
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Wan
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
mesh_terms: D000328:Adult; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D018895:Microsatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011247:Pregnancy; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm