title: A comparison of modelling techniques for computing wall stress in abdominal aortic aneurysms.
abstract: BACKGROUND
  Aneurysms, in particular abdominal aortic aneurysms (AAA), form a significant portion of cardiovascular related deaths. There is much debate as to the most suitable tool for rupture prediction and interventional surgery of AAAs, and currently maximum diameter is used clinically as the determining factor for surgical intervention. Stress analysis techniques, such as finite element analysis (FEA) to compute the wall stress in patient-specific AAAs, have been regarded by some authors to be more clinically important than the use of a "one-size-fits-all" maximum diameter criterion, since some small AAAs have been shown to have higher wall stress than larger AAAs and have been known to rupture.
  
  
  METHODS
  A patient-specific AAA was selected from our AAA database and 3D reconstruction was performed. The AAA was then modelled in this study using three different approaches, namely, AAA(SIMP), AAA(MOD) and AAA(COMP), with each model examined using linear and non-linear material properties. All models were analysed using the finite element method for wall stress distributions.
  
  
  RESULTS
  Wall stress results show marked differences in peak wall stress results between the three methods. Peak wall stress was shown to reduce when more realistic parameters were utilised. It was also noted that wall stress was shown to reduce by 59% when modelled using the most accurate non-linear complex approach, compared to the same model without intraluminal thrombus.
  
  
  CONCLUSIONS
  The results here show that using more realistic parameters affect resulting wall stress. The use of simplified computational modelling methods can lead to inaccurate stress distributions. Care should be taken when examining stress results found using simplified techniques, in particular, if the wall stress results are to have clinical importance.
authors.affiliation: Centre for Applied Biomedical Engineering Research (CABER), Department of Mechanical and Aeronautical Engineering and Materials and Surface Science Institute, University of Limerick, Ireland. barry.doyle@ul.ie
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Doyle
authors.forename: Anthony
authors.initials: A
authors.lastname: Callanan
authors.forename: Timothy M
authors.initials: TM
authors.lastname: McGloughlin
mesh_terms: D001012:Aorta, Abdominal / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical