title: Prolonged, severe intrathecal baclofen withdrawal syndrome: a case report.
abstract: Intrathecal baclofen (ITB) withdrawal is a well-recognized complication when drug delivery is disrupted for any reason. ITB withdrawal varies widely in its severity and poses the very real possibility of death if not promptly managed. Cases of withdrawal lasting greater than 1 or 2 weeks, however, are sparse. We report the case of an 11-year-old girl with spastic quadriplegic cerebral palsy who developed an infected pump and subsequent meningitis, prompting the removal of her pump and catheter. She subsequently developed a severe, prolonged baclofen withdrawal syndrome marked by increased spasticity, agitation, hypertension, and tachycardia that lasted nearly 2 months, requiring intensive care and continuous intravenous sedation with benzodiazepines and opiates. Her pump was eventually replaced on hospital day 56 and within 24 hours her symptoms dramatically improved. She was eventually weaned off sedating medications and returned to baseline functional status. Typical management of baclofen withdrawal is reviewed. To date, the literature has not discussed the potential role for opiates in managing baclofen withdrawal, yet a growing body of literature is examining the interplay between opiates and gamma-aminobutyric acid B pathways. A potential role for opiates in managing severe baclofen withdrawal is proposed.
authors.affiliation: Division of Physical Medicine and Rehabilitation, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
authors.forename: Colby R
authors.initials: CR
authors.lastname: Hansen
authors.forename: Judith L
authors.initials: JL
authors.lastname: Gooch
authors.forename: Teresa
authors.initials: T
authors.lastname: Such-Neibar
mesh_terms: D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects*; D002547:Cerebral Palsy / Q000534:rehabilitation*; D002648:Child; D003422:Critical Care; D003428:Cross Infection / Q000209:etiology; D020878:Device Removal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004866:Equipment Contamination; D004868:Equipment Failure; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000382:microbiology; D007278:Injections, Spinal; D016920:Meningitis, Bacterial / Q000209:etiology; D008874:Midazolam / Q000008:administration & dosage; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D009460:Neurologic Examination / Q000187:drug effects; D011552:Pseudomonas Infections / Q000209:etiology; D011782:Quadriplegia / Q000534:rehabilitation*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen; D008874:Midazolam