title: Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide iota.
abstract: The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemic Josiphos-related ligand (R,S)-PPF-P(t-Bu)2 was successfully used to introduce each of three stereocenters found in the target compound.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. lipshutz@chem.ucsb.edu
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
authors.forename: Ching-Tien
authors.initials: CT
authors.lastname: Lee
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Servesko