[Oxidative stress in a rat model of dietary-induced obesity].
OBJECTIVE
To evaluate the levels of antioxidative indexes, lipid metabolism and glycometabolism in high fat diet-induced obese rats.


METHODS
A rat model of high fat diet induced obesity was established by feeding weaning male Sprague-Dawley rats with high-fat diet for 10 weeks. plasma 8-epi-prostaglandin-F2 (8-epi-PGF2), alpha-tocopherol, superoxide dismutase activity (SOD), and glutathione peroxidase activity (GSH-Px) were detected. Parameters of lipid metabolism and glycometabolism were also tested by standard methods.


RESULTS
After 10 weeks, the high fat diet-induced obesity and lipid metabolism and glycometabolism disorders of obese rats (n = 10) were found. In the comparison with the control groups (n = 10), plasma 8-epi-PGF2 levels of obese rats were more higher, while plasma adjusted alpha-tocopherol (divided by plasma lipids), SOD and GSH-Px activities of obese rats were more lower.


CONCLUSIONS
Obesity induced by high-fat feeding involves increased oxidative stress and decreased antioxidant capacity.
Shen
Xiuhua
X
Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Clinical Nutrition Center, Shanghai XinHua Hospital, Shanghai 200092, China.
Cai
Wei
W
Tang
Qingya
Q
Feng
Yi
Y
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
D004041:Dietary Fats; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol