title: [The effect of cyclovirobuxinum D on myocardial ischemia induced by coronary artery ligation in rats].
abstract: OBJECTIVE
  To study the cardiac protection of Cyclovirobuxinum D (Cvb-D) in rats model.
  
  
  METHODS
  The rats were subjected to left main coronary artery occlusion. The change about S-T segment, the area of myocardial injury (necrotic and ischemic areas), the amount of cardiac tissue malondialdehyde (MDA), the cardiactissue creatine phosphokinase (CPK) and the cardiac tissue superoxide dismutase (SOD) activation were measured.
  
  
  RESULTS
  Compared to the model group, Cvb-D (1.1 mg/kg, 2.2 mg/kg dos-age) significantly reduce myocardial damage, reduce myocardial ischemia mode rats' sigma s-t of ECG, significantly reduce cardiac tissue CPK activation and MDA content, raise the cardiac tissue SOD activation in the rats with myocardial ischemia.
  
  
  CONCLUSIONS
  Cvb-D is effective in treatment of myocardial ischemia in rats.
authors.affiliation: Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Jiu-yao
authors.initials: JY
authors.lastname: Zhou
authors.forename: Yi-dong
authors.initials: YD
authors.lastname: Sun
authors.forename: Yong-heng
authors.initials: YH
authors.lastname: Tan
authors.forename: Su-jian
authors.initials: SJ
authors.lastname: Deng
authors.forename: Gui-ying
authors.initials: GY
authors.lastname: Huang
mesh_terms: D000818:Animals; D031235:Buxus / Q000737:chemistry; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003331:Coronary Vessels / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D008026:Ligation / Q000009:adverse effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; C524545:cyclovirobuxinum D; D008315:Malondialdehyde; D013482:Superoxide Dismutase