Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland.
Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected.
Greve
Bernhard
B
Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany. bernhard.greve@uni-tuebingen.de
Simonenko
Rostislav
R
Illes
Zsolt
Z
Peterfalvi
Agnes
A
Hamdi
Nada
N
Mycko
Marcin P
MP
Selmaj
Krzysztof W
KW
Rozsa
Csilla
C
Rajczy
Katalin
K
Bauer
Peter
P
Berger
Klaus
K
Weissert
Robert
R
D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D060908:CTLA-4 Antigen; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D006814:Hungary; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*; D011044:Poland; D011110:Polymorphism, Genetic
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human