title: Simulated mossy fiber associated feedforward circuit functioning as a highpass filter.
abstract: Learning and memory rely on the strict regulation of communication between neurons in the hippocampus. The mossy fiber (MF) pathway connects the dentate gyrus to the auto-associative CA3 network, and the information it carries is controlled by a feedforward circuit combining disynaptic inhibition with monosynaptic excitation. Analysis of the MF associated circuit using a mapped clock oscillator (MCO) model reveals the circuit to be a highpass filter.
authors.affiliation: Inst. for Biomater. & Biomed. Eng., Toronto Univ., Ontario, Canada.
authors.forename: Osbert C
authors.initials: OC
authors.lastname: Zalay
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakjian
mesh_terms: D000465:Algorithms; D002525:Cerebellar Cortex / Q000473:pathology*; D018891:Dentate Gyrus / Q000473:pathology*; D004594:Electrophysiology; D004867:Equipment Design; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D017774:Long-Term Potentiation; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000473:pathology*; D009991:Oscillometry / Q000379:methods; D012984:Software; D009435:Synaptic Transmission; D013997:Time Factors