title: Acute hepatitis in a patient with familial Mediterranean fever.
abstract: Familial Mediterranean fever (FMF) is a hereditary syndrome characterized by recurrent episodes of fever and serositis. In this report, we describe a Japanese patient with FMF and Sjögren's syndrome, in whom acute elevations of transaminase occurred. The histological findings from the liver biopsy specimens demonstrated a nonspecific hepatitis, with liver cell necrosis and interlobular inflammatory cell invasion, without the presence of interface hepatitis or bile duct injury. This case underscores the possibility that MEFV mutations contribute to hepatic inflammation, as seen in this case, by way of an alteration of the pyrin function.
authors.affiliation: Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan. migita@nmc.hosp.go.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Seigo
authors.initials: S
authors.lastname: Abiru
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Taichiro
authors.initials: T
authors.lastname: Miyashita
authors.forename: Yumi
authors.initials: Y
authors.lastname: Maeda
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
authors.forename: Minoru
authors.initials: M
authors.lastname: Nakamura
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Komori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuhashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ida
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirayama
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishibashi
mesh_terms: D018925:Chemokines / Q000378:metabolism; D003078:Colchicine / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D010505:Familial Mediterranean Fever / Q000150:complications / Q000235:genetics*; D005260:Female; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007564:Japan; D008875:Middle Aged; D000071198:Pyrin
chemical_list: D018925:Chemokines; D016207:Cytokines; D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine