Do reproductive hormones explain the association between body mass index and semen quality?
OBJECTIVE
To examine whether reproductive hormones play a role in the association between body mass index (BMI) and semen quality.


METHODS
Semen quality and testosterone (T), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E(2)) were evaluated in 990 fertile males with age 38.9 +/- 9.7 (mean +/- SD) years recruited from the Chinese general population in 2001 and 2002.


RESULTS
Semen quality was reduced among underweight (BMI < 18.5) compared with normal (BMI 18.5-24.9) and overweight (BMI 25.0-29.9), but the associations were independent of reproductive hormones. After adjustment for the potential confounders, underweight men had reductions in sperm concentration (22.4 X 10(6)/mL), total sperm count (52.9 X 10(6)) and percentage of normal sperm forms (6.9%) compared with men with normal BMI. Being underweight may be a risk factor for low sperm concentration (OR: 4.68, 95% confidence intervals [CI]: 2.01-10.91). Otherwise, being overweight may be a protected factor for low sperm concentration (OR: 0.25; 95% CI: 0.08-0.83) and low total sperm count (OR: 0.37, 95% CI: 0.15-0.87).


CONCLUSIONS
Low BMI was associated with reduced semen quality. The associations between BMI and semen quality were found statistically significant even after adjustment for reproductive hormones. Reproductive hormones cannot explain the association between BMI and semen quality.
Qin
Dan-Dan
DD
School of Public Health, Fudan University, Shanghai 200433, China.
Yuan
Wei
W
Zhou
Wei-Jin
WJ
Cui
Yuan-Qi
YQ
Wu
Jun-Qing
JQ
Gao
Er-Sheng
ES
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002681:China; D004958:Estradiol / Q000097:blood*; D005298:Fertility / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000502:physiology*; D013076:Sperm Count; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone