title: Guiding periodontal pocket recolonization: a proof of concept.
abstract: The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effectiveness in the treatment of periodontitis is unknown. Therefore, this study addressed the hypothesis that the application of selected beneficial bacteria, as an adjunct to scaling and root planing, would inhibit the periodontopathogen recolonization of periodontal pockets. Analysis of the data showed, in a beagle dog model, that when beneficial bacteria were applied in periodontal pockets adjunctively after root planing, subgingival recolonization of periodontopathogens was delayed and reduced, as was the degree of inflammation, at a clinically significant level. The study confirmed the hypothesis and provides a proof of concept for a guided pocket recolonization (GPR) approach in the treatment of periodontitis.
authors.affiliation: Catholic University Leuven, Research Group for Microbial Adhesion, Department of Periodontology, Kapucijnenvoer 7, 3000 Leuven, Belgium. Wim.Teughels@med.kuleuven.be
authors.forename: W
authors.initials: W
authors.lastname: Teughels
authors.forename: M G
authors.initials: MG
authors.lastname: Newman
authors.forename: W
authors.initials: W
authors.lastname: Coucke
authors.forename: A D
authors.initials: AD
authors.lastname: Haffajee
authors.forename: H C
authors.initials: HC
authors.lastname: Van Der Mei
authors.forename: S Kinder
authors.initials: SK
authors.lastname: Haake
authors.forename: E
authors.initials: E
authors.lastname: Schepers
authors.forename: J-J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: J
authors.initials: J
authors.lastname: Van Eldere
authors.forename: D
authors.initials: D
authors.lastname: van Steenberghe
authors.forename: M
authors.initials: M
authors.lastname: Quirynen
mesh_terms: D000818:Animals; D000898:Antibiosis; D001421:Bacteria, Anaerobic / Q000502:physiology; D001439:Bacteroides / Q000502:physiology; D015169:Colony Count, Microbial; D004285:Dogs; D004311:Double-Blind Method; D008297:Male; D010514:Periodontal Pocket / Q000382:microbiology* / Q000628:therapy*; D019936:Probiotics / Q000627:therapeutic use*; D011897:Random Allocation; D016745:Root Planing; D034361:Streptococcus mitis / Q000502:physiology; D013298:Streptococcus sanguis / Q000502:physiology