title: [Treatment of a septic shock due to multiresistant Acinetobacter baumannii with tigecycline in combination].
abstract: We report a case of pulmonary and bloodstream infection due to multiresistant Acinetobacter baumannii six days after a severe trauma. Clinical condition transiently improved following antimicrobial treatment with ticarcillin-clavulanate and rifampicin. However, a septic shock developed on the fourth day due to the emergence of a strain only sensible to cotrimoxazole, colistin and tigecycline. Cure was achieved after a two week treatment with piperacillin-tazobactam, cotrimoxazole and tigecycline. This case shows that combined antimicrobial therapy including tigecycline can be relevant in some severe pulmonary infections due to multiresistant A. baumannii.
authors.affiliation: Service d'anesthésie-réanimation, HIA Percy, 101, avenue H. Barbusse, 92141 Clamart cedex, France. thomas.leclerc@m4x.org
authors.forename: T
authors.initials: T
authors.lastname: Leclerc
authors.forename: J-P
authors.initials: JP
authors.lastname: Perez
authors.forename: B
authors.initials: B
authors.lastname: Debien
authors.forename: P
authors.initials: P
authors.lastname: Clapson
authors.forename: B
authors.initials: B
authors.lastname: Lenoir
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications*; D040981:Acinetobacter baumannii; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000008:administration & dosage*; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology*; D000078142:Tazobactam; D000078304:Tigecycline; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000078304:Tigecycline; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D010397:Penicillanic Acid; D008911:Minocycline; D000078142:Tazobactam; D010878:Piperacillin