title: Whole genome linkage disequilibrium maps in cattle.
abstract: BACKGROUND
  Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation with economically important traits and also provides background information concerning the extent of long range linkage disequilibrium in cattle.
  
  
  RESULTS
  Linkage disequilibrium was assessed using r2 among all pairs of syntenic markers within eight breeds of cattle from the Bos taurus and Bos indicus subspecies. Bos taurus breeds included Angus, Charolais, Dutch Black and White Dairy, Holstein, Japanese Black and Limousin while Bos indicus breeds included Brahman and Nelore. Approximately 2670 markers spanning the entire bovine autosomal genome were used to estimate pairwise r2 values. We found that the extent of linkage disequilibrium is no more than 0.5 Mb in these eight breeds of cattle.
  
  
  CONCLUSIONS
  Linkage disequilibrium in cattle has previously been reported to extend several tens of centimorgans. Our results, based on a much larger sample of marker loci and across eight breeds of cattle indicate that in cattle linkage disequilibrium persists over much more limited distances. Our findings suggest that 30,000-50,000 loci will be needed to conduct whole genome association studies in cattle.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. Stephen.Moore@afhe.ualberta.ca
authors.forename: Stephanie D
authors.initials: SD
authors.lastname: McKay
authors.forename: Robert D
authors.initials: RD
authors.lastname: Schnabel
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Murdoch
authors.forename: Lakshmi K
authors.initials: LK
authors.lastname: Matukumalli
authors.forename: Jan
authors.initials: J
authors.lastname: Aerts
authors.forename: Wouter
authors.initials: W
authors.lastname: Coppieters
authors.forename: Denny
authors.initials: D
authors.lastname: Crews
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Dias Neto
authors.forename: Clare A
authors.initials: CA
authors.lastname: Gill
authors.forename: Chuan
authors.initials: C
authors.lastname: Gao
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mannen
authors.forename: Paul
authors.initials: P
authors.lastname: Stothard
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Wang
authors.forename: Curt P
authors.initials: CP
authors.lastname: Van Tassell
authors.forename: John L
authors.initials: JL
authors.lastname: Williams
authors.forename: Jeremy F
authors.initials: JF
authors.lastname: Taylor
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Moore
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D005787:Gene Frequency; D005819:Genetic Markers; D016678:Genome; D006239:Haplotypes; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers