title: Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging.
abstract: A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After (64)Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.
authors.affiliation: Department of Radiology, The University of Virginia, 409 Lane Road, MR4 Building 1192, PO Box 801339, Charlottesville, VA 22908, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
authors.forename: Karen D
authors.initials: KD
authors.lastname: Fairchild
authors.forename: Landon
authors.initials: L
authors.lastname: Locke
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Berr
authors.forename: Joel
authors.initials: J
authors.lastname: Linden
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Pan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D010455:Peptides