title: Efficacy of triclosan soap against superficial dermatomycoses: a double-blind clinical trial in 224 primary school-children in Kilombero District, Morogoro Region, Tanzania.
abstract: BACKGROUND
  Superficial dermatomycoses are a common problem in tropical regions. Due to limited resources, specific antimycotic therapy is often not available. The present study was performed to assess the clinical efficacy of the antimicrobial agent Triclosan in bar soap in comparison with regular soap against selected superficial dermatomycoses in Tanzanian schoolchildren.
  
  
  METHODS
  820 primary school children were examined for skin disorders and 224 of these were included in the soap trial. The clinical presentation of dermatomycoses was recorded using a symptom score. Samples were taken for microscopic examination and mycological culture. The study participants received either bar soap containing Triclosan or a placebo for 2 months. They were re-examined at the end of this period.
  
  
  RESULTS
  The benefit achieved by the addition of Triclosan was not statistically significant. Overall cure rates for Triclosan and placebo groups taken together were 21.8% for tinea versicolor, 58.3% for tinea capitis, 55.5% for tinea corporis and 68.8% for tinea pedis. This was confirmed microscopically. For the majority of the children the dermatomycoses improved significantly.
  
  
  CONCLUSIONS
  The results strongly argue for regular soap use against common dermatomycoses as a low-cost and effective treatment. This promising finding should be considered in settings where dermatophyte infections represent a public health problem and where access to appropriate treatment and financial resources are limited.
authors.affiliation: Department of Medicine and Diagnostics, Swiss Tropical Institute, Basel, Switzerland.
authors.forename: Almuth
authors.initials: A
authors.lastname: Dinkela
authors.forename: Julia
authors.initials: J
authors.lastname: Ferié
authors.forename: Marco
authors.initials: M
authors.lastname: Mbata
authors.forename: Marco
authors.initials: M
authors.lastname: Schmid-Grendelmeier
authors.forename: Christoph
authors.initials: C
authors.lastname: Hatz
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008290:Malassezia / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D012915:Soaps / Q000737:chemistry / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013636:Tanzania; D014005:Tinea / Q000188:drug therapy*; D014010:Tinea Versicolor / Q000188:drug therapy*; D016896:Treatment Outcome; D014249:Trichophyton / Q000302:isolation & purification; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D012915:Soaps; D014260:Triclosan