title: Pre-ictal entropy analysis of microwire data from an animal model of limbic epilepsy.
abstract: Epilepsy is a common neurological disorder that can have damaging effects in the brain including over 50% loss of neuronal activity in the hippocampal regions of the CA1 and CA3. The pre-ictal period was studied in an animal model of limbic epilepsy using Shannon entropy and correlation analysis. The primary aim was to uncover underlying relative changes in signals between the Dentate Gyrus and CA1 areas of the bilateral hippocampus. Preliminary entropy analysis results included dynamical changes between channels in the Dentate Gyrus and channels in the CA1 region at and around the time of the seizure.
authors.affiliation: Dept. of Biomed. Eng., Florida Univ., Gainesville, FL, USA.
authors.forename: Mitushi
authors.initials: M
authors.lastname: Mishra
authors.forename: Britta
authors.initials: B
authors.lastname: Jones
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Simonotto
authors.forename: Michael D
authors.initials: MD
authors.lastname: Furman
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Norman
authors.forename: Zhao
authors.initials: Z
authors.lastname: Liu
authors.forename: Thomas B
authors.initials: TB
authors.lastname: DeMarse
authors.forename: Paul R
authors.initials: PR
authors.lastname: Carney
authors.forename: William L
authors.initials: WL
authors.lastname: Ditto
mesh_terms: D000465:Algorithms; D000818:Animals; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D019277:Entropy; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D006624:Hippocampus / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology; D051381:Rats