Crosstalk of tight junction components with signaling pathways.
Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree of sealing varies according to external stimuli, physiological and pathological conditions. In this review we analyze how the crosstalk of protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinases, phosphoinositide 3-kinase and Rho signaling pathways is involved in TJ regulation triggered by diverse stimuli. We also report how the phosphorylation of the main TJ components, claudins, occludin and ZO proteins, impacts epithelial and endothelial cell function.
González-Mariscal
Lorenza
L
Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, Ave. Instituto Politécnico Nacional 2508, México D. F. 07360, México. lorenza@fisio.cinvestav.mx
Tapia
Rocio
R
Chamorro
David
D
D000595:Amino Acid Sequence; D000818:Animals; D016764:Cell Polarity; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000502:physiology; D006801:Humans; D020935:MAP Kinase Signaling System; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D008969:Molecular Sequence Data; D009219:Myosin-Light-Chain Kinase / Q000502:physiology; D062793:Occludin; D019899:Paracrine Communication; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D019108:Tight Junctions / Q000737:chemistry / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000502:physiology
D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; D019869:Phosphatidylinositol 3-Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D017869:Cyclic GMP-Dependent Protein Kinases; D011493:Protein Kinase C; D009219:Myosin-Light-Chain Kinase; D010749:Phosphoprotein Phosphatases; D020741:rho GTP-Binding Proteins