title: A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones.
abstract: Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.
authors.affiliation: Education Faculty, Kafkas University, 36100 Kars, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Alkan
authors.forename: Haydar
authors.initials: H
authors.lastname: Yüksek
authors.forename: Fatih
authors.initials: F
authors.lastname: Islamoğlu
authors.forename: Sule
authors.initials: S
authors.lastname: Bahçeci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calapoğlu
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Elmastaş
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Akşit
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozdemir
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D005292:Ferricyanides / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010851:Picrates; D011199:Potentiometry; D013057:Spectrum Analysis; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005292:Ferricyanides; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D014230:Triazoles; C007931:hexacyanoferrate III; C004931:1,1-diphenyl-2-picrylhydrazyl