title: A comparison of different choices for the regularization parameter in inverse electrocardiography models.
abstract: Calculating the potentials on the heart's epicardial surface from the body surface potentials constitutes one form of inverse problems in electrocardiography (ECG). Since these problems are ill-posed, one approach is to use zero-order Tikhonov regularization, where the squared norms of both the residual and the solution are minimized, with a relative weight determined by the regularization parameter. In this paper, we used three different methods to choose the regularization parameter in the inverse solutions of ECG. The three methods include the L-curve, the generalized cross validation (GCV) and the discrepancy principle (DP). Among them, the GCV method has received less attention in solutions to ECG inverse problems than the other methods. Since the DP approach needs knowledge of norm of noises, we used a model function to estimate the noise. The performance of various methods was compared using a concentric sphere model and a real geometry heart-torso model with a distribution of current dipoles placed inside the heart model as the source. Gaussian measurement noises were added to the body surface potentials. The results show that the three methods all produce good inverse solutions with little noise; but, as the noise increases, the DP approach produces better results than the L-curve and GCV methods, particularly in the real geometry model. Both the GCV and L-curve methods perform well in low to medium noise situations.
authors.affiliation: Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou.
authors.forename: Guofa
authors.initials: G
authors.lastname: Shou
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Jiang
authors.forename: Ling
authors.initials: L
authors.lastname: Xia
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Stuart
authors.initials: S
authors.lastname: Crozier
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology; D008564:Membrane Potentials; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D016276:Ventricular Function