[Response of isolated coronary artery strips to noradrenaline in the presence of desoxycorticosterone].
The effect of desoxycorticosterone on the noradrenaline-induced relaxation of coronary arteries was studied "in vitro". It resulted that the effect of noradrenaline was enhanced by desoxycorticosterone. It is concluded that desoxycorticosterone potentiates the effects of noradrenaline by inhibiting its inactivation by Catechol-O-methyltransferase.
Bettini
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V
Istituto di Fisiologia Umana dell'Università di Padova.
Legrenzi
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E
Bortolozzo
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L
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D066298:In Vitro Techniques; D008901:Mineralocorticoids / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D008901:Mineralocorticoids; D014662:Vasoconstrictor Agents; D003900:Desoxycorticosterone; D009638:Norepinephrine