title: [Response of antileptospira IgG antibodies in individuals immunized with vax-SPIRAL].
abstract: A quantitative ELISA for the detection of IgG antibodies in response to the Cuban vaccine against the human leptospirosis (vax-SPIRAL) was applied to 930 volunteers'sera, 483 immunized with vax-SPIRAL and 447 with a vaccine against hepatitis B. Samples were taken before beginning the study, 21 days after the second dose and a year later. A high seroprevalence of antibodies to the vaccine serovars was observed before beginning the study. The initial value of the response doubled at 21 days of the second dose in 45 % of the individuals. There were markedly significant differences (p=0,000000) between both groups. A similar response to the three leptospiral serovars was found. After the year the levels of antibodies decreased; however, 23.1% of the individuals were able to duplicate their level of antibodies regarding the initial moment, and the significant difference with the group that received the vaccine against hepatitis B still existed. The application of this Cuban immunogen amomg the main risk groups was recommended.
authors.affiliation: Instituto de Medicina Tropical Pedro Kouri, Marianao, Ciudad de La Habana. islay@ipk.sld.cu
authors.forename: Islay
authors.initials: I
authors.lastname: Rodríguez
authors.forename: Raydel
authors.initials: R
authors.lastname: Martínez
authors.forename: Yarelys
authors.initials: Y
authors.lastname: Zamora
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Rodríguez
authors.forename: Carmen
authors.initials: C
authors.lastname: Fernández
authors.forename: Ana Margarita
authors.initials: AM
authors.lastname: Obregón
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003462:Cuba; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007921:Leptospira interrogans / Q000276:immunology*; D041341:Leptospira interrogans serovar canicola / Q000276:immunology; D007922:Leptospirosis / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D017325:Hepatitis B Vaccines; D007074:Immunoglobulin G