Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine.
Persistence of antibodies following a single dose of Tdap vaccine (tetanus, diphtheria, and five-component acellular pertussis vaccine for use in individuals past childhood) was evaluated in a follow-up of adolescents (N=324) and adults (N=644) who had received Tdap in earlier clinical trials. Outcome measures were seroprotection (tetanus and diphtheria) or seropositivity (pertussis) and geometric mean titers. Humoral immune responses to all antigens were robust 1 month after initial immunization; antibodies exceeded pre-immunization levels 1, 3, and 5 years later. These data will contribute to selecting the optimal interval for booster doses of Tdap.
Barreto
L
L
Sanofi Pasteur Limited, 1755 Steeles Avenue West, Toronto, Ontario M2R 3T4, Canada. luis.barreto@sanofipasteur.com
Guasparini
R
R
Meekison
W
W
Noya
F
F
Young
L
L
Mills
E
E
D000293:Adolescent; D000328:Adult; D000906:Antibodies; D000917:Antibody Formation; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007117:Immunization, Secondary; D017778:Vaccines, Combined / Q000009:adverse effects / Q000276:immunology
D000906:Antibodies; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D017778:Vaccines, Combined