title: Thyroglobulin reference values in a pediatric infant population.
abstract: Few reports have addressed normal serum thyroglobulin (Tg) values in newborns and infants. In the present study, serum Tg was measured in 228 normal children (110 females and 118 males) aged from 3 to 180 days of life, all presenting normal age-related serum thyrotropin (thyroid-stimulating hormone [TSH]) values and negative anti-Tg and antithyroperoxidase antibodies. Serum Tg was measured by Radioimmunoassay (RIA) (two methods) and Immunometricassay (IMA) (three methods). Mean Tg values measured by the five methods exhibited among-method biases, although a significant positive correlation was observed. Serum Tg levels measured by the five methods showed a correlation with age, but not with TSH or gender. During the first days of life, relatively high mean Tg levels were observed, which progressively decreased until they reached a plateau. Therefore, with the aim of establishing reference values, the population was separated into two age groups: from 3 to 15 days of life (group A) and from 16 to 180 days of life (group B). Mean Tg concentration in group A was statistically higher than in group B. Tg centile distributions were calculated with the aim of establishing the normal levels of serum Tg for each method. We conclude that for a correct interpretation of serum Tg levels, the age and the methods used should be considered.
authors.affiliation: Servicio de Endocrinología, Hospital de Niños de la Santísima Trinidad, Córdoba, Argentina. gmsobrero@gmail.com
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sobrero
authors.forename: Liliana
authors.initials: L
authors.lastname: Muñoz
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bazzara
authors.forename: Silvia
authors.initials: S
authors.lastname: Martin
authors.forename: Liliana
authors.initials: L
authors.lastname: Silvano
authors.forename: Sonia
authors.initials: S
authors.lastname: Iorkansky
authors.forename: Liliana
authors.initials: L
authors.lastname: Bergoglio
authors.forename: Carole
authors.initials: C
authors.lastname: Spencer
authors.forename: Mirta
authors.initials: M
authors.lastname: Miras
mesh_terms: D000375:Aging / Q000097:blood; D004563:Electrochemistry; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D015592:Immunoradiometric Assay; D007223:Infant; D007231:Infant, Newborn; D008163:Luminescent Measurements; D008297:Male; D011863:Radioimmunoassay; D012016:Reference Values; D013954:Thyroglobulin / Q000097:blood*
chemical_list: D013954:Thyroglobulin