title: Glucose production by deconvolution in intravenous and oral glucose tolerance tests: role of output variable.
abstract: Endogenous glucose production (EGP) after a glucose stimulus can be estimated by deconvolution of the endogenous component of glucose concentration, which is computed from noisy measurements. This study analyzes how measurement errors propagate to endogenous glucose and affect EGP reconstruction during intravenous (IVGTT) and oral (MEAL) glucose tolerance tests. Monte Carlo simulations show that the effect of errors on endogenous glucose and thus on EGP is more critical during IVGTT than during MEAL. A two regularization-parameter deconvolution technique for IVGTT is proposed, which successfully handles this added difficulty.
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy. marloch@dei.unipd.it
authors.forename: Marco
authors.initials: M
authors.lastname: Chierici
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Pillonetto
authors.forename: Gianna
authors.initials: G
authors.lastname: Toffolo
authors.forename: Claudio
authors.initials: C
authors.lastname: Cobelli
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism; D004333:Drug Administration Routes; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D015203:Reproducibility of Results; D013816:Thermodynamics; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose