title: Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China.
abstract: OBJECTIVE
  To evaluate the impact of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms on esophageal cancer risk.
  
  
  METHODS
  One hundred and ninety-one esophageal cancer patients and 198 healthy controls from Yanting County were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase-chain-reaction with the confronting-two-pair-primer (PCR-CTPP) method. Unconditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence interval (95% CI).
  
  
  RESULTS
  Both ADH2 1 allele and ALDH2 1/ 2 allele showed an increased risk of developing esophageal cancer. The adjusted OR (95% CI) for ADH2 1 allele compared with ADH2 2/ 2 was 1.65 (95% CI = 1.02-2.68) and 1.67 (95% CI = 1.02-2.72) for ALDH2 1/ 2 compared with ALDH2 1/ 1. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk, the OR was 1.83 (95% CI = 1.13-2.95). Furthermore, when compared with ADH2 2/ 2 and ALDH2 1/ 1 carriers, ADH2 1 and ALDH2 2 carriers showed an elevated risk of developing esophageal cancer among non-alcohol drinkers (OR = 2.46, 95% CI = 0.98-6.14), and a significantly elevated risk of developing esophageal cancer among alcohol drinkers among alcohol drinkers (OR = 9.86, 95% CI = 3.10-31.38).
  
  
  CONCLUSIONS
  ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. ADH2 1 allele and ALDH2 2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers.
authors.affiliation: Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Yang
authors.forename: Hua-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Li
authors.forename: Hui-Zhang
authors.initials: HZ
authors.lastname: Du
authors.forename: Can-Jie
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Huai-Gong
authors.initials: HG
authors.lastname: Chen
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Mu
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000009:adverse effects; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial