title: 1H MRS spectroscopy evidence of cerebellar high lactate in mitochondrial respiratory chain deficiency.
abstract: Cerebellar ataxia is known to occasionally occur in the course of mitochondrial disorders. We report on MR spectroscopy (1H MRS) evidence of elevated brain lactate in the cerebellar area of 11 patients with cerebellar ataxia ascribed to mitochondrial respiratory chain deficiency (RCD). 1H MRS spectroscopy evidence of lactate peak was found in the cerebellum of 9/11 cases, while no lactate was detected in the putamen in 8/11. We suggest using 1H MRS in cerebellar atrophy in the diagnosis of mitochondrial RCD.
authors.affiliation: Service de radiologie pédiatrique, U797, Hôpital Necker Enfants-Malades, 149 rue de Sèvres, Paris, France. nathalie.boddaert@nck.aphp.fr
authors.forename: N
authors.initials: N
authors.lastname: Boddaert
authors.forename: S
authors.initials: S
authors.lastname: Romano
authors.forename: B
authors.initials: B
authors.lastname: Funalot
authors.forename: M
authors.initials: M
authors.lastname: Rio
authors.forename: E
authors.initials: E
authors.lastname: Sarzi
authors.forename: A S
authors.initials: AS
authors.lastname: Lebre
authors.forename: N
authors.initials: N
authors.lastname: Bahi-Buisson
authors.forename: V
authors.initials: V
authors.lastname: Valayannopoulos
authors.forename: I
authors.initials: I
authors.lastname: Desguerre
authors.forename: D
authors.initials: D
authors.lastname: Seidenwurm
authors.forename: F
authors.initials: F
authors.lastname: Brunelle
authors.forename: F
authors.initials: F
authors.lastname: Brami-Zylberberg
authors.forename: A
authors.initials: A
authors.lastname: Rötig
authors.forename: A
authors.initials: A
authors.lastname: Munnich
authors.forename: P
authors.initials: P
authors.lastname: de Lonlay
mesh_terms: D000293:Adolescent; D002524:Cerebellar Ataxia / Q000175:diagnosis; D002531:Cerebellum / Q000737:chemistry* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019344:Lactic Acid / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D028361:Mitochondrial Diseases / Q000378:metabolism* / Q000473:pathology; D011522:Protons; D012189:Retrospective Studies
chemical_list: D011522:Protons; D019344:Lactic Acid