Cancer chemotherapy in young children: challenges and solutions.
Young children with cancer are a therapeutic challenge both in terms of chemotherapeutic efficacy as well as toxicity. The ontogeny of each drug differs, and hence, general rules cannot easily apply. Each drug should be studied by itself before rational cancer therapy for young children can be offered. Much more focus on this age group is needed to improve survival, while ensuring their long-term quality of life of these children.
Koren
Gideon
G
Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. gkoren@sickkids.ca
Schechter
Tali
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*