A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time.
The patient was a 55-year-old female. On the diagnosis of the right acoustic tumor, a subtotal extirpation was performed. Heparinized solution was administered, and on postoperative day 7, an occlusion of the left common femoral artery was confirmed. A continuous administration of heparin was initiated after a thrombectomy. On the following day, the platelet count decreased. Following confirmation of the recurrence of thromboembolism, we again performed a thrombectomy. Considering the possibility of heparin-induced thrombocytopenia (HIT), we terminated the administration of heparin, and treatment with danaparoid and argatroban was initiated. Two days later, she redeveloped thromboembolism. After the administration of danaparoid was terminated, the platelet count improved.
Masumoto
Hidetoshi
H
Department of Cardiovascular Surgery, Shizuoka City Hospital, Shizuoka, Japan.
Shimamoto
Mitsuomi
M
Yamazaki
Fumio
F
Nakai
Masanao
M
Fujita
Shoji
S
Itonaga
Tatsuya
T
Nomura
Ryota
R
D000925:Anticoagulants / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D003871:Dermatan Sulfate / Q000008:administration & dosage; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006497:Heparan Sulfate / Q000008:administration & dosage; D006801:Humans; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D010875:Pipecolic Acids / Q000008:administration & dosage; D012008:Recurrence; D013449:Sulfonamides; D017131:Thrombectomy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000517:prevention & control; D013923:Thromboembolism / Q000139:chemically induced* / Q000601:surgery
D000925:Anticoagulants; D001120:Arginine; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006493:Heparin; D006497:Heparan Sulfate; D010875:Pipecolic Acids; D013449:Sulfonamides; C035838:danaparoid; C031942:argatroban