Structure of Bombyx mori chemosensory protein 1 in solution.
Chemosensory Proteins (CSPs) represent a family of conserved proteins found in insects that may be involved in chemosensory functions. BmorCSP1 is expressed mainly in antennae and legs of the silkworm moth Bombyx mori and was cloned from antennal cDNA. Here we report the determination of the structure of Bombyx mori CSP1 (BmorCSP1) by NMR. The overall fold of BmorCSP1 is globular and comprises six alpha-helices. These helices span residues 10-14, 17-27, 35-49, 57-72, 75-85, and 92-100. The internal hydrophobic sides of the helices are formed mostly by leucine and isoleucine residues and, therefore, well suited to constitute a binding site for hydrophobic ligands.
Jansen
Séverine
S
Department of Ecology, Lund University, Lund, Sweden.
Chmelík
Josef
J
Zídek
Lukás
L
Padrta
Petr
P
Novák
Petr
P
Zdráhal
Zbynek
Z
Picimbon
Jean-François
JF
Löfstedt
Christer
C
Sklenár
Vladimír
V
D000818:Animals; D012831:Bombyx / Q000378:metabolism*; D003001:Cloning, Molecular; D019476:Insect Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary
C412286:CSP1 protein, Bombyx mori; D019476:Insect Proteins