title: Heat transfer model of hyporthermic intracarotid infusion of cold saline for stroke therapy.
abstract: A 3-dimensional hemispheric computational brain model is developed to simulate infusion of cold saline in the carotid arteries in terms of brain cooling for stroke therapy. The model is based on the Pennes bioheat equation, with four tissue layers: white matter, gray matter, skull, and scalp. The stroke lesion is simulated by reducing blood flow to a selected volume of the brain by a factor of one-third, and brain metabolism by 50%. A stroke penumbra was also generated surrounding the core lesion (blood volume reduction 25%, metabolism reduction 20%). The finite difference method was employed to solve the system of partial differential equations. This model demonstrated a reduction in brain temperature, at the stroke lesion, to 32 degrees C in less than 10 minutes.
authors.affiliation: Dept. of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Neimark
authors.forename: Angelos-Aristeidis
authors.initials: AA
authors.lastname: Konstas
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Laine
authors.forename: John
authors.initials: J
authors.lastname: Pile-Spellman
mesh_terms: D001831:Body Temperature; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D002339:Carotid Arteries / Q000503:physiopathology*; D003080:Cold Temperature; D003198:Computer Simulation; D004735:Energy Transfer; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008954:Models, Biological; D012965:Sodium Chloride / Q000627:therapeutic use*; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy*; D013813:Therapy, Computer-Assisted / Q000379:methods; D013814:Thermal Conductivity; D016896:Treatment Outcome
chemical_list: D012965:Sodium Chloride