Layer-by-Layer adsorption of biocompatible polyelectrolytes onto dexamethasone aggregates.
Using layer-by-layer technology in drug delivery systems is advantageous because of its high precision, mild assembly conditions, and ease of use. In this study, we investigate the use of such a system using a micronized dexamethasone core as the building template. Dexamethasone was chosen because of its hydrophobic structure and role as a cellular differentiation factor. Structural characterization of the assembled structures shows particle size distribution between 3-10 mum with 20% more dissolution than free drug crystals. Additionally, as a measure of drug activity post-encapsulation, in vitro cell culture studies were performed. We suggest that the polyelectrolyte coatings enhance release and augment production of extracellular matrix proteins aggrecan and collagen II.
Stewart
Skylar S
SS
Biomedical Engineering Program, Ruston, LA 71270, USA. stewart@latech.edu
Roldan
Jorge E
JE
Lvov
Yuri M
YM
Mills
David K
DK
D000327:Adsorption; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003907:Dexamethasone / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing
D018931:Antineoplastic Agents, Hormonal; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004573:Electrolytes; D046911:Macromolecular Substances; D003907:Dexamethasone