[Vitamin D insufficiency--possible etiologic factor of autoimmune diseases].
The primary source of vitamin D in humans is sun exposure to the skin. The incidence of certain autoimmune diseases correlates positively with latitude. As vitamin D production increases with sun exposure, vitamin D insufficiency is hypothesised to influence the development of autoimmune diseases. In experimental animal and cellular studies in vitro 1.25-(OH)2-vitamin D reduces inflammation. This article discusses the role of vitamin D in inflammatory bowel disease, type 1 diabetes mellitus, multiple sclerosis, and rheumatoid arthritis.
Jørgensen
Søren Peter
SP
Arhus Universitetshospital, Arhus Sygehus, Medicinsk Hepato-gastroenterologisk Afdeling V. spgjo@as.aaa.dk
Bartels
Lars Erik
LE
Agnholt
Jørgen
J
Glerup
Henning
H
Nielsen
Søren Lyhne
SL
Hvas
Christian Lodberg
CL
Dahlerup
Jens F
JF
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000276:immunology; D051379:Mice; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology; D014807:Vitamin D / Q000008:administration & dosage / Q000096:biosynthesis / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
D014807:Vitamin D