[Association between the +491C/T polymorphism of beta2-adrenergic receptor gene and risk of essential hypertension in Kazakns of Xinjiang].
OBJECTIVE
To investigated the association between the +491C/T polymorphism of beta2-AR gene and risk of essential hypertension (EH) in Kazakns of Xinjiang.


METHODS
In this population-based case-control study, we recruited 507 Kazakns subjects (289 EH and 218 normotensives, aged from 30 - 60 years old) from the pastoral areas in Xinjiang. Peripheral blood were collected and the DNA was extracted by means of a standard phenol-chloroform method. The +491C/T genotypes of beta2-AR was identified by PCR-restriction fragment length polymorphism analysis. The distribution of genotypic and allelic frequencies between EH and controls were also compared.


RESULTS
The frequencies of the genotype CC, CT were 98.82% and 1.18%, respectively and there was no TT genotype in this population, the genotype distribution was consistent with Hardy-Weinberg equilibrium (chi2 = 0.018, P = 0.893). CC and CT genotypic frequencies were 97.92% and 2.08% respectively in EH, while there was no CT genotype in normotensives. The allelic frequencies of C, T were significantly different between EH (98.96%, 1.04%) and normotensives (100%, 0%, all P = 0.040). Systolic blood pressure and diastolic blood pressure were similar in subjects with various genotypes in the whole population (P > 0.05) but systolic blood pressure was significantly higher in males with CT genotype compared with males with CC genotype (P = 0.046).


CONCLUSIONS
The +491C/T polymorphism of beta2-AR gene is associated with essential hypertension and is a possible susceptible factor for essential hypertension in Kazakns of Xinjiang.
Li
Nan-fang
NF
Hypertension Institute of Xinjiang, Hypertension Unit of the People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Urumqi 830001, China. lnanfang@yahoo.com.cn
Zhou
Ling
L
Li
Tao
T
Wang
Hong-mei
HM
Liu
Hui
H
Hu
Jun-li
JL
D044466:Asian People / Q000235:genetics; D001794:Blood Pressure; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012494:Sampling Studies
D018343:Receptors, Adrenergic, beta-2