title: NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols.
abstract: BACKGROUND
  Although natural products represent a reservoir of molecular diversity, the process of isolating and identifying active compounds is a bottleneck in drug discovery programs. The rapid isolation and identification of the bioactive component(s) of natural product mixtures during the bioassay-guided fractionation have become crucial factors in the competition with chemical compound libraries and combinatorial synthetic efforts. In this respect, the use of spectral databases in identification processes is indispensable.
  
  
  RESULTS
  We have developed a database containing (13)C spectral information of over 6000 natural compounds, which allows for fast identifications of known compounds present in the crude extracts and provides insight into the structural elucidation of unknown compounds.
  
  
  BACKGROUND
  http://c13.usal.es
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Campus M. Unamuno, Universidad de Salamanca, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Pérez
authors.forename: Roberto
authors.initials: R
authors.lastname: Therón
authors.forename: Esther
authors.initials: E
authors.lastname: del Olmo
authors.forename: David
authors.initials: D
authors.lastname: Díaz
mesh_terms: D001681:Biological Assay / Q000379:methods*; D001688:Biological Products / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D045424:Complex Mixtures / Q000737:chemistry*; D003628:Database Management Systems; D016208:Databases, Factual; D020407:Internet; D013058:Mass Spectrometry / Q000379:methods*; D014584:User-Computer Interface
chemical_list: D001688:Biological Products; D045424:Complex Mixtures