Effects of vehicles and enhancers on transdermal delivery of clebopride.
The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 microg/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.
Rhee
Yun-Seok
YS
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
Huh
Jai-Yong
JY
Park
Chun-Woong
CW
Nam
Tae-Young
TY
Yoon
Koog-Ryul
KR
Chi
Sang-Cheol
SC
Park
Eun-Seok
ES
D000279:Administration, Cutaneous; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D010539:Permeability; D014677:Pharmaceutical Vehicles; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D012995:Solubility
D001549:Benzamides; D014677:Pharmaceutical Vehicles; C014417:clebopride