[Effect of systemic chemotherapy on clinical status and biological and immunologic markers in patients with breast cancer].
Complex examination of breast cancer patients (102, aged 35-63) receiving systemic polychemotherapy was carried out to make a case for a course of immunotherapy. Cycles of chemotherapy were given to all patients. Basal immunological status revealed T-cell and non-specific immunity suppression, disordered cytokine regulation, lowered nitrite concentration and enhanced SOD and catalase levels. Chemotherapy was followed by more frequent immunopathological syndromes and graver immunosuppression. The dynamics of biochemical parameters was characterized by decreasing antioxidant system activity.
Orlova
R V
RV
Chernetsova
L F
LF
Matveeva
O N
ON
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology*; D002374:Catalase / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008875:Middle Aged; D009573:Nitrites / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013601:T-Lymphocytes / Q000187:drug effects
D000975:Antioxidants; D014408:Biomarkers, Tumor; D016207:Cytokines; D009573:Nitrites; D002374:Catalase; D013482:Superoxide Dismutase