title: Blood bank management of sickle cell patients at comprehensive sickle cell centers.
abstract: BACKGROUND
  Transfusion therapy has been integral to decreasing morbidity and mortality in sickle cell disease (SCD). Several studies however, have demonstrated variation in the blood bank (BB) practices for these patients. The purpose of this study was to examine BB practices for SCD patients at NIH Comprehensive Sickle Cell Centers (CSCCs) and to determine whether consensus in BB management exists.
  
  
  METHODS
  A cross-sectional survey of BB medical directors and laboratory supervisors at CSCCs was conducted between October 2004 and March 2005. The survey assessed respondent, hospital, and BB characteristics; pretransfusion procedures; blood product selection; and agreement with statements about consensus in management. Physician respondents were also asked to select their preferred management strategy in four hypothetical transfusion-related cases.
  
  
  RESULTS
  Responses were received from 36 of 49 (73.5%) institutions. Pretransfusion procedures and blood product selection were nearly uniform among CSCCs. Of the respondents, 69 percent disagreed with the statement that clear consensus exists on the use of phenotypically matched red blood cells for SCD patients; 55 percent disagreed that clear consensus exists on the use of chronic transfusion programs for SCD patients. Although there was consensus on the use of transfusion therapy for life- or organ-threatening situations, optimal management of preoperative transfusion therapy and severe delayed transfusion reactions appears controversial.
  
  
  CONCLUSIONS
  This study provides the first overview of BB management of patients with SCD at CSCCs and identifies areas where there is perceived and actual lack of consensus. These results suggest that opportunities remain to standardize transfusion practices for SCD patients across all hospital settings.
authors.affiliation: Department of Pathology & Laboratory Medicine and the Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27514-7600, USA. araba_afenyi-annan@med.unc.edu
authors.forename: Araba
authors.initials: A
authors.lastname: Afenyi-Annan
authors.forename: Monte S
authors.initials: MS
authors.lastname: Willis
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Konrad
authors.forename: Richard
authors.initials: R
authors.lastname: Lottenberg
mesh_terms: D000755:Anemia, Sickle Cell / Q000628:therapy*; D000094902:Blood Banking / Q000379:methods*; D001803:Blood Transfusion / Q000592:standards; D032921:Consensus; D003430:Cross-Sectional Studies; D003625:Data Collection; D019468:Disease Management; D006268:Health Facilities; D006801:Humans; D012015:Reference Standards