title: A computational model of cardiac electromechanics.
abstract: Driven by the need for a more anatomically realistic ventricular model and with access to greater computational power the Auckland porcine ventricular model has been re-engineered based on the original anatomical recordings. The model retains an accurate representation of the ventricular geometry including the apex and valve rings and also the underlying tissue microstructure. A computational modeling and simulation framework is used to embed biophysically detailed models of cellular electromechanics in the large scale anatomical model. This enables the integrative investigation of feedback mechanisms between the structure and function at the cellular and tissue scales with the macroscopic factors that govern the beating of the heart.
authors.affiliation: Bioengineering Institute, University of Auckland, New Zealand. d.nickerson@auckland.ac.nz
authors.forename: David
authors.initials: D
authors.lastname: Nickerson
authors.forename: Steven
authors.initials: S
authors.lastname: Niederer
authors.forename: Carey
authors.initials: C
authors.lastname: Stevens
authors.forename: Martyn
authors.initials: M
authors.lastname: Nash
authors.forename: Peter
authors.initials: P
authors.lastname: Hunter
mesh_terms: D000818:Animals; D004285:Dogs; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods*; D020342:Finite Element Analysis; D006321:Heart / Q000502:physiology; D006329:Heart Conduction System; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009716:Numerical Analysis, Computer-Assisted; D012212:Rheology; D012984:Software; D013552:Swine