title: IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4.
abstract: The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.
authors.affiliation: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
authors.forename: Iain
authors.initials: I
authors.lastname: MacArthur
authors.forename: Paul B
authors.initials: PB
authors.lastname: Mann
authors.forename: Eric T
authors.initials: ET
authors.lastname: Harvill
authors.forename: Andrew
authors.initials: A
authors.lastname: Preston
mesh_terms: D001884:Bordetella / Q000145:classification* / Q000472:pathogenicity*; D001885:Bordetella Infections / Q000503:physiopathology*; D006801:Humans; D008050:Lipid A / Q000737:chemistry / Q000633:toxicity*; D008958:Models, Molecular; D013045:Species Specificity; D051197:Toll-Like Receptor 4 / Q000502:physiology*
chemical_list: D008050:Lipid A; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4