title: Anti-tumour clerodane-type diterpenes from Mitrephora thorelii.
abstract: Bioassay-guided fractionation of the crude extract of Mitrephora thorelii (Annonaceae) led to the isolation of two clerodane-type diterpenes. Their structures were characterised on the basis of spectroscopic methods as 6alpha,16,18-trihydroxycleroda-3(4),13(14)-dien-15,16-olide (1) and 16-hydroxycleroda-3(4),13(14)-dien-15,16-olide (2). Compound 1 is a new compound. Compounds 1 and 2 exhibited inhibitory activity against the proliferation of human hepatoma BEL-7402 cells in vitro. Compound 2 also showed an in vivo anti-tumour effect against the growth of hepatoma H22 in mice.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Meng
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Xu
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhao
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D045785:Diterpenes, Clerodane