[Influence of desoxycorticosterone on the response of coronary artery segments to adrenaline in the presence of pyrogallol].
The effect of desoxycorticosterone on the adrenaline-induced relaxation of coronary arteries was studied in vitro, after a known inhibitor of COMT, pyrogallol. Relaxation induced by adrenaline was enhanced by desoxycorticosterone. Relaxation in response to adrenaline was increased by desoxycorticosterone. Pyrogallol potentiated the responses of coronary strips to adrenaline and also reduced or abolished the enhancing effects of desoxycorticosterone. It is concluded that desoxycorticosterone enhances the response of coronary smooth muscle to adrenaline by inhibiting an enzymatic pathway for the inactivation of catecholamines.
Bettini
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V
Istituto di Fisiologia Umana dell'Università di Padova.
Legrenzi
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E
Lovato
A
A
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008901:Mineralocorticoids / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D011748:Pyrogallol / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D000975:Antioxidants; D008901:Mineralocorticoids; D014662:Vasoconstrictor Agents; D011748:Pyrogallol; D003900:Desoxycorticosterone; D004837:Epinephrine