Microwave-assisted Suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites.
A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to approximately 24 h under thermal conditions, corresponding to a approximately 72-fold increase in reaction rate.
Sharma
Arun K
AK
Department of Pharmacology, Chemical Carcinogenesis and Chemoprevention Program of Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA. aks14@psu.edu
Gowdahalli
Krishnegowda
K
Krzeminski
Jacek
J
Amin
Shantu
S
D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D013237:Stereoisomerism
D011084:Polycyclic Aromatic Hydrocarbons