Use of dye as tracer of drug release from medicated chewing gums.
The evaluation of the potential use of a dye as indicator of in vivo drug release from a medicated chewing gum is described. The device is a three-layer tablet obtained by direct compression consisting of a gum core and two external protective soluble layers to prevent gum adhesion to the punches of the tableting machine. The active ingredient and a colour are contained in the gum core. To evaluate the drug and the dye release from the formulations, a chew-out study was performed by a panel of volunteers. The results obtained suggest that the use of a dye could be useful to indicate the chewing time necessary to complete drug delivery from medicated chewing gums.
Ochoa
Evelyn
E
Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy. labtec2@unipv.it
Maggi
Lauretta
L
Conti
Stefania
S
Conte
Ubaldo
U
Vergnault
Guy
G
Grenier
Pascal
P
D002638:Chewing Gum; D004396:Coloring Agents; D004304:Dosage Forms; D008787:Metoclopramide / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013607:Tablets
D002638:Chewing Gum; D004396:Coloring Agents; D004304:Dosage Forms; D013607:Tablets; D008787:Metoclopramide