title: Influence of the k-space trajectory on the dynamic T1-weighted signal in quantitative first-pass cardiac perfusion MRI at 3T.
abstract: The dynamic T(1)-weighted signal in first-pass myocardial perfusion MRI can vary as a function of k-space trajectory. The purpose of this study, therefore, was to compare the relative T(1)-weighted signal produced by the linear, centric, and reverse centric k-space trajectories at 3T. The centric k-space trajectory yielded higher arterial input function (AIF) than the linear and reverse centric k-space trajectories (6.21 +/- 0.84 vs. 4.75 +/- 0.75 vs. 4.39 +/- 0.85 mM, respectively; N = 9; P < 0.01), and the reverse centric k-space trajectory yielded higher myocardial signal contrast (as a fraction of equilibrium magnetization) than the linear and centric k-space trajectories (0.17 +/- 0.02 vs. 0.12 +/- 0.02 vs. 0.05 +/- 0.01, respectively; N = 9; P < 0.001). Compared to the linear k-space trajectory, the centric k-space trajectory is relatively optimal for the quantification of AIF, whereas the reverse centric k-space trajectory is relatively optimal for high contrast of myocardial wall enhancement.
authors.affiliation: Department of Radiology, New York University, New York, New York 10016, USA. dan.kim@med.nyu.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Kim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology*; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA