title: Inflammation and clinical repercussions of pleurodesis induced by intrapleural talc administration.
abstract: Although reports on pleurodesis date back to the beginning of the 20th century, the search for the ideal sclerosing agent is ongoing. Several agents have been studied and used, but talc continues to be the most popular. However, potentially harmful systemic side effects have been associated with talc pleurodesis. In this article we discuss the likely mechanisms of pleural inflammation and pleurodesis with emphasis on the systemic response due to the instillation of talc into the pleural space.
authors.affiliation: Laboratory of Pleura, Pulmonary Division - Heart Institute (InCor)-University of São Paulo Medical School, Brazil. ehgenofre@uol.com.br
authors.forename: Eduardo Henrique
authors.initials: EH
authors.lastname: Genofre
authors.forename: Evaldo
authors.initials: E
authors.lastname: Marchi
authors.forename: Francisco S
authors.initials: FS
authors.lastname: Vargas
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D010996:Pleural Effusion / Q000628:therapy; D018700:Pleurodesis / Q000009:adverse effects* / Q000379:methods; D013627:Talc / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D013627:Talc