title: Synthesis of novel sterically demanding carbo- and heterocyclic beta-ketoesters.
abstract: We present an easy method for the synthesis of beta-ketoesters starting from various carbocyclic and heterocyclic carboxylic acids and esters. The beta-ketoester side-chain was introduced by a sequence involving alpha-deprotonation and quenching with CO(2), conversion to the corresponding acid chloride and subsequent chain elongation using deprotonated ethyl acetate.
authors.affiliation: Vienna University of Technology - Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria. mmihovil@ioc.tuwien.ac.at
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
authors.forename: Thomas C M
authors.initials: TC
authors.lastname: Fischer
authors.forename: Peter
authors.initials: P
authors.lastname: Stanetty
mesh_terms: D004952:Esters; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D004952:Esters; D006571:Heterocyclic Compounds