Synthesis of novel sterically demanding carbo- and heterocyclic beta-ketoesters.
We present an easy method for the synthesis of beta-ketoesters starting from various carbocyclic and heterocyclic carboxylic acids and esters. The beta-ketoester side-chain was introduced by a sequence involving alpha-deprotonation and quenching with CO(2), conversion to the corresponding acid chloride and subsequent chain elongation using deprotonated ethyl acetate.
Mihovilovic
Marko D
MD
Vienna University of Technology - Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria. mmihovil@ioc.tuwien.ac.at
Fischer
Thomas C M
TC
Stanetty
Peter
P
D004952:Esters; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D004952:Esters; D006571:Heterocyclic Compounds