[Expression and function of p63 gene in epithelial cells].
The presented data indicate that the p63 gene is required for the commitment of epidermal stem cells in embryonic development. At the same time, p63 underlies many functions involved in the self-renewal of stem cells in the adult epidermis. Its expression provides for keratinocyte adhesion, inhibits apoptosis, and maintains the integrity of the epidermal tissue.
Voroteliak
E A
EA
Chermnykh
E S
ES
Tkachenko
S B
SB
Vasil'ev
A V
AV
Terskikh
V V
VV
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004817:Epidermis / Q000196:embryology*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D004268:DNA-Binding Proteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins