Fixation artefact in an intra-operative frozen section: a potential cause of misinterpretation.
The intra-operative histological assessment of fresh tissue can provide valuable diagnostic information and guide surgical management, however, even a limited exposure to standard fixation agents can potentially compromise analysis. Defined handling strategies should exist to facilitate the receipt of all specimens, in their optimal state, by the laboratory.
Thomson
Andrew M
AM
Division of Pathology, College of Medicine and Veterinary Medicine, The University of Edinburgh and Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh. Andrew.Thomson@luht.scot.nhs.uk
Wallace
William A
WA
D000369:Aged, 80 and over; D016477:Artifacts; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000601:surgery; D003951:Diagnostic Errors / Q000517:prevention & control; D005404:Fixatives; D005629:Frozen Sections / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D013048:Specimen Handling / Q000009:adverse effects
D005404:Fixatives