title: Growth environment and sex differences in lipids, body shape and diabetes risk.
abstract: BACKGROUND
  Sex differences in lipids and body shape, but not diabetes, increase at puberty. Hong Kong Chinese are mainly first or second generation migrants from China, who have shared an economically developed environment for years, but grew up in very different environments in Hong Kong or contemporaneously undeveloped Guangdong, China. We assessed if environment during growth had sex-specific associations with lipids and body shape, but not diabetes.
  
  
  RESULTS
  We used multivariable regression in a population-based cross-sectional study, undertaken from 1994 to 1996, of 2537 Hong Kong Chinese residents aged 25 to 74 years with clinical measurements of ischaemic heart disease (IHD) risk, including HDL-cholesterol, ApoB, diabetes and obesity. Waist-hip ratio was higher (mean difference 0.01, 95% CI 0.001 to 0.02) in men, who had grown up in an economically developed rather than undeveloped environment, as was apolipoprotein B (0.05 g/L, 95% CI 0.001 to 0.10), adjusted for age, socio-economic status and lifestyle. In contrast, the same comparison was associated in women with lower waist-hip ratio (-0.01, 95% CI -0.001 to -0.02) and higher HDL-cholesterol (0.05 mmol/L, 95% CI 0.0004 to 0.10). The associations in men and women were significantly different (p-values<0.001). There were no such differences for diabetes.
  
  
  CONCLUSIONS
  Growth in a developed environment with improved nutrition may promote higher sex-steroids at puberty producing an atherogenic lipid profile and male fat pattern in men but the opposite in women, with tracking of increased male IHD risk into adult life.
authors.affiliation: Department of Community Medicine and School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. cms1@hkucc.hku.hk
authors.forename: C Mary
authors.initials: CM
authors.lastname: Schooling
authors.forename: Tai Hing
authors.initials: TH
authors.lastname: Lam
authors.forename: G Neil
authors.initials: GN
authors.lastname: Thomas
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Cowling
authors.forename: Michelle
authors.initials: M
authors.lastname: Heys
authors.forename: Edward D
authors.initials: ED
authors.lastname: Janus
authors.forename: Gabriel M
authors.initials: GM
authors.lastname: Leung
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis; D049628:Body Size; D002681:China; D003920:Diabetes Mellitus / Q000208:ethnology / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D012306:Risk; D012727:Sex Characteristics
chemical_list: D008055:Lipids