Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
Amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid were synthesized and evaluated for their anti-inflammatory and analgesic activity. Few selected compounds were also screened for their antipyretic, anti-arthritic, and ulcerogenic potential. Most of the compounds exhibited good activity profile and were free of gastrointestinal toxicity of common NSAIDs. However these compounds failed to decrease secondary lesions of adjuvant induced arthritis and also did not inhibit TNF-alpha in lipopolysaccharide induced pyresis.
Sharma
Meenakshi
M
Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani 333031, India.
Ray
S M
SM
D000085:Acetates / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000577:Amides / Q000737:chemistry*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D001168:Arthritis / Q000188:drug therapy / Q000473:pathology; D002351:Carrageenan / Q000494:pharmacology; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D007192:Indenes / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D014456:Ulcer / Q000139:chemically induced*
C525799:5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid; D000085:Acetates; D000577:Amides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D007192:Indenes; D002351:Carrageenan; D003577:Cytochrome P-450 Enzyme System