Metabolite quantification and high-field MRS in breast cancer.
In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have been made to evaluate the role of 1H MRS measurements of total choline-containing compounds in the management of patients with breast cancer. Current technological developments, including the use of high-field MR scanners and quantitative spectroscopic analysis methods, promise to increase the sensitivity and accuracy of breast MRS. This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high-field MR scanning and quantitative methods. Potential applications of these technologies for diagnosing suspicious lesions and monitoring response to chemotherapy are discussed.
Haddadin
Ihab S
IS
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
McIntosh
Adeka
A
Meisamy
Sina
S
Corum
Curt
C
Styczynski Snyder
Angela L
AL
Powell
Nathaniel J
NJ
Nelson
Michael T
MT
Yee
Douglas
D
Garwood
Michael
M
Bolan
Patrick J
PJ
D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D055442:Metabolome