Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension".
Curtis et al. (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a true ventricular extension.
Sanai
Nader
N
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143-0112, USA. sanain@neurosurg.ucsf.edu
Berger
Mitchel S
MS
Garcia-Verdugo
Jose Manuel
JM
Alvarez-Buylla
Arturo
A
D000328:Adult; D002465:Cell Movement; D049109:Cell Proliferation; D048430:Cell Shape; D006801:Humans; D020547:Lateral Ventricles / Q000166:cytology*; D039842:Neural Cell Adhesion Molecule L1 / Q000032:analysis; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016548:Prosencephalon / Q000166:cytology; D012794:Sialic Acids / Q000032:analysis; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology* / Q000502:physiology
D039842:Neural Cell Adhesion Molecule L1; D018809:Proliferating Cell Nuclear Antigen; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule