[The effect of cyclovirobuxinum D on myocardial ischemia induced by coronary artery ligation in rats].
OBJECTIVE
To study the cardiac protection of Cyclovirobuxinum D (Cvb-D) in rats model.


METHODS
The rats were subjected to left main coronary artery occlusion. The change about S-T segment, the area of myocardial injury (necrotic and ischemic areas), the amount of cardiac tissue malondialdehyde (MDA), the cardiactissue creatine phosphokinase (CPK) and the cardiac tissue superoxide dismutase (SOD) activation were measured.


RESULTS
Compared to the model group, Cvb-D (1.1 mg/kg, 2.2 mg/kg dos-age) significantly reduce myocardial damage, reduce myocardial ischemia mode rats' sigma s-t of ECG, significantly reduce cardiac tissue CPK activation and MDA content, raise the cardiac tissue SOD activation in the rats with myocardial ischemia.


CONCLUSIONS
Cvb-D is effective in treatment of myocardial ischemia in rats.
Zhou
Jiu-yao
JY
Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Sun
Yi-dong
YD
Tan
Yong-heng
YH
Deng
Su-jian
SJ
Huang
Gui-ying
GY
D000818:Animals; D031235:Buxus / Q000737:chemistry; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003331:Coronary Vessels / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D008026:Ligation / Q000009:adverse effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; C524545:cyclovirobuxinum D; D008315:Malondialdehyde; D013482:Superoxide Dismutase