title: Gene interactions in depression: pathways out of darkness.
abstract: Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors. Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified. Recently, the immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder. New candidate genes and emerging gene networks and pathways involved in the aetiology of mood disorders point to a major role for neuronal survival and the adaptive immune systems.
authors.affiliation: Department of Neuroscience, CHUL Research Centre and Laval University, Quebec, QC, Canada.
authors.forename: Mario
authors.initials: M
authors.lastname: Harvey
authors.forename: Pascal
authors.initials: P
authors.lastname: Belleau
authors.forename: Nicholas
authors.initials: N
authors.lastname: Barden
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D030541:Databases, Genetic; D003865:Major Depressive Disorder / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic; D039781:PubMed; D018048:Receptors, Purinergic P2 / Q000235:genetics; D058486:Receptors, Purinergic P2X7
chemical_list: C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7