title: [Benefits and limitations of vacuum therapy in wounds].
abstract: OBJECTIVE
  Establish the benefits and limitations of vacuum-assisted wound closure therapy (VWT) on the basis on "best evidence".
  
  
  METHODS
  The core of the review was an internet-based literature search based on the criteria of the Cochrane Collaboration, supplemented by an additional manual search. The identified literature was evaluated and selected following a specified algorithm. The therapeutic benefit was determined using the current benefit definitions of SGB V, GBA and IQWiG, with emphasis on the patient's perspective and on daily routine.
  
  
  RESULTS
  The online search revealed n=674 publications on VWT. After the additional manual searching, a total of n=269 original papers filled the criteria for evaluation. The criteria and methods of evaluation for so varied in the clinical studies despite the same indications that no comparative meta-analyses of individual therapy goals could be carried out. Most studies also revealed methodological deficits. A majority of analyzed studies indicate an effectiveness and clinical benefit for VWT.
  
  
  CONCLUSIONS
  VWT is a standard approach in Germany for treating problematic acute and chronic wounds. It is often an essential treatment option given it's effectiveness in many indications. VWT also has marked clinical benefits from the patient's perspective.
authors.affiliation: CVderm-Competenzzentrum Versorgungsforschung in der Dermatologie und Hochschulambulanz für Wunden Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg. m.augustin@uke.uni-hamburg.de
authors.forename: M
authors.initials: M
authors.lastname: Augustin
authors.forename: K
authors.initials: K
authors.lastname: Herberger
mesh_terms: D000208:Acute Disease; D000465:Algorithms; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005858:Germany; D006801:Humans; D020407:Internet; D015337:Multicenter Studies as Topic; D054843:Negative-Pressure Wound Therapy / Q000592:standards; D017060:Patient Satisfaction; D018570:Risk Assessment; D016896:Treatment Outcome; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*