[Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance].
OBJECTIVE
To evaluate expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance.


METHODS
The immunohistochemical method and the in situ hybridization were employed in detecting the NF-kappaB p65 expressions in surgical specimen from 48 laryngeal carcinoma and 20 normal mucous membrane.


RESULTS
(1) The expression of NF kappaB p65 was higher than in normal laryngeal mucous membrane. (2) Positive expression of NF-kappaB p65 correlated with the development of distant metastasis.


CONCLUSIONS
The results of the study show that the NF-kappaB p65 protein is a significant predictor of survival in laryngeal carcinoma patients.
Zhang
Lihong
L
Department of Otolaryngology, People's Hospital of Beijing University, Beijing, 100044, China. Lihongzhang@vip.sina.com
Jing
Yuanyuan
Y
Yu
Lisheng
L
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000378:metabolism* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D051996:Transcription Factor RelA / Q000378:metabolism*; D055815:Young Adult
C498143:RELA protein, human; D051996:Transcription Factor RelA