title: [Alcohol, metabolic syndrome and obesity: impact on treatment efficacy].
abstract: Among environmental factors, alcohol consumption and metabolic syndrome should play a major role on the response to treatment in chronic hepatitis C. In a prospective study, regular alcohol consumption (1 drink/d) within 6 months prior to bi-therapy in patients with chronic hepatitis C was significantly associated with treatment stop, underlining the need for specific and multidisciplinary management of those patients. Metabolic steatosis and overall the degree of insulin resistance assessed by HOMA index, also seem to have negative impact on sustained virological response to treatment. The high prevalence of insulin resistance in chronic hepatitis C warrant performing metabolic investigations before to start antiviral treatment. Efficacy of insulin sensitizing agents on virological response in patients treated with bi-therapy is under investigation in randomized controlled trials.
authors.affiliation: INSERM U680, Service d'Hépatologie, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France. lawrence.serfaty@sat.aphp.fr
authors.forename: Lawrence
authors.initials: L
authors.lastname: Serfaty
authors.forename: Philippe
authors.initials: P
authors.lastname: Mathurin
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cadranel
authors.forename: Albert
authors.initials: A
authors.lastname: Tran
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000998:Antiviral Agents / Q000494:pharmacology; D024882:Drug Resistance, Viral; D005234:Fatty Liver / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology*
chemical_list: D000998:Antiviral Agents