title: Deep subsurface Raman spectroscopy of turbid media by a defocused collection system.
abstract: A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.
authors.affiliation: Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Eliasson
authors.forename: M
authors.initials: M
authors.lastname: Claybourn
authors.forename: P
authors.initials: P
authors.lastname: Matousek
mesh_terms: D003102:Colloids / Q000737:chemistry*; D045424:Complex Mixtures / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods*
chemical_list: D003102:Colloids; D045424:Complex Mixtures