DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy.
DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often mutated or inactive in tumours. Here, we discuss how such deficiencies can in turn be exploited for cancer therapy.
Petermann
E
E
Radiation Oncology and Biology, University of Oxford, Oxford OX3 7LJ, U.K.
Helleday
T
T
D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D009369:Neoplasms / Q000628:therapy*