title: Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.
abstract: Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action.
authors.affiliation: Laboratory of Protein Dynamics and Signaling, Building 560 Room 22-103, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, United States.
authors.forename: Zlatka
authors.initials: Z
authors.lastname: Kostova
authors.forename: Yien Che
authors.initials: YC
authors.lastname: Tsai
authors.forename: Allan M
authors.initials: AM
authors.lastname: Weissman
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008322:Mammals; D011506:Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D044767:Ubiquitin-Protein Ligases