Cytogenetic study of bone marrow and blood cells in patients with non-Hodgkin lymphoma before and after antitumor therapy.
Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incident were clones -22, del(1)(q42-43), del(2)(q-33-35), del(3)(q27), 4q-, and del(6q).
Ankina
M A
MA
Department of Cell and Experimental Radiotherapy, Medical Radiology Center, Russian Academy of Medical Sciences, Obninsk. anka@dezigners.ru
Zavitaeva
T A
TA
Panferova
T A
TA
Shakhtarina
S V
SV
Pavlov
V V
VV
D000293:Adolescent; D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D002869:Chromosome Aberrations; D003582:Cytogenetics / Q000379:methods*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011123:Polyploidy