title: Engineering of fiber-reinforced tissues with anisotropic biodegradable nanofibrous scaffolds.
abstract: The repair of dense fiber-reinforced tissues poses a significant challenge for the tissue engineering community. The function of these structures is largely dependent on their architectural form, and as such, scaffold organization is an important design parameter in generating tissue analogues. To address this issue, we have recently utilized electrospinning to instill controllable fiber anisotropy in nanofibrous scaffolds. This abstract details the mechanical characterization of the bulk and local properties of these scaffolds, and points to their potential application in the repair and/or generation of fiber-reinforced tissues that recapitulate the native form.
authors.affiliation: Department of Mechanical Engineering, Pennsylvania University, Philadelphia, PA 19104, USA. nerurkar@seas.upenn.edu
authors.forename: Nandan L
authors.initials: NL
authors.lastname: Nerurkar
authors.forename: Brendon M
authors.initials: BM
authors.lastname: Baker
authors.forename: Chiu-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Elliott
authors.forename: Robert L
authors.initials: RL
authors.lastname: Mauck
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D016880:Anisotropy; D001672:Biocompatible Materials / Q000737:chemistry; D002417:Cattle; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D004548:Elasticity; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone