title: [Sperm chromatin integrity disturbances in infertile men].
abstract: OBJECTIVE
  A survey of knowledge and detection methods of sperm chromatin integrity disturbances.
  
  
  METHODS
  Review of literature.
  
  
  METHODS
  Veterinary Research Institute, Brno.
  
  
  METHODS
  A survey of experience with detection methods for human sperm chromatin integrity disturbances.
  
  
  CONCLUSIONS
  Disturbed sperm chromatin integrity manifested as an increase in DNA strand breaks within the spermatozoa and deficient chromosome condensation in the sperm nucleus is one of the causes of male infertility. Various approaches to the detection of such defects have been described. The methods differ above all in the time and expenses required, and robustness. The review brings a survey of the most commonly used procedures, and compares advantages and disadvantages of respective methods.
authors.affiliation: Výzkumný ústav veterinárního lékarství, vvi, Brno.
authors.forename: R
authors.initials: R
authors.lastname: Rybár
authors.forename: J
authors.initials: J
authors.lastname: Rubes
mesh_terms: D002843:Chromatin / Q000235:genetics*; D053960:DNA Breaks; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D013094:Spermatozoa
chemical_list: D002843:Chromatin