[Thyroid disorders in pregnancy and after delivery].
During pregnancy, normal thyroid activity undergoes significant changes. Endocrine adaptation to pregnancy involves changes in iodine metabolism, serum thyroxine binding globulin, chorionic gonadotropin, suppressed immune activity and the small enlargement of the thyroid gland, particularly in iodine-deficient areas. Consequently, pregnancy and the postpartum period often influence on the course of pre-existing thyroid diseases, which are encountered frequently in pregnant women and after delivery. In addition, some thyroid diseases occurring exclusively during these periods may develop. Most of the thyroid disorders in pregnancy and postpartum period are treatable but may affect mother and foetus adversely if they are not evaluated and managed appropriately. In this paper, the pathophysiology, clinical presentation, diagnosis and management of different thyroid diseases during pregnancy and postpartum period are reviewed. Particular attention is devoted to the results of recently published studies.
Krysiak
Robert
R
Katedra Farmakologii, Zakład Farmakologii Klinicznej, Slaskiej Akademii Medycznej, 40-752 Katowice, ul Medyków 18. r.krysiak@interia.pl
Okopień
Bogusław
B
Szkróbka
Witold
W
Herman
Zbigniew Stanisław
ZS
D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000503:physiopathology; D006111:Graves Disease / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D049590:Postpartum Period / Q000097:blood / Q000276:immunology; D050032:Postpartum Thyroiditis / Q000097:blood / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology*; D012307:Risk Factors; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy; D013961:Thyroid Gland / Q000502:physiology / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D006063:Chorionic Gonadotropin; D013963:Thyroid Hormones; D013972:Thyrotropin; D007455:Iodine