title: [Histological and morphometric analysis of the raw areas treated with a silicone membrane: study in rats].
abstract: BACKGROUND
  This study evaluated the effects of a silicone membrane on the treatment of the raw flesh area in wounds.
  
  
  METHODS
  The experimental study was carried out with 30 male Wistar rats divided into three groups: in the GG group, the raw area was treated with gauze, in the GH group with homograft, and in the GS group with a silicone membrane. Animals were sacrificed at fourteen days of postoperative. The studied attributes were body mass variation, histological study quantified by morphometric analysis evaluating the number of neovessels, fibroblasts, collagen fibers, leucocytes, monocytes; and using a micrometric ruler measurement of the raw area's thickness. Data were then submitted to statistical analysis.
  
  
  RESULTS
  There was no significant difference between the animals' mass (p=0.0685). Predominance of neovessels (p<0.01), fibroblasts (p<0.001) and thickness of the raw flesh were observed in G S animals. There was predominance of leucocytes (p<0.021) and monocytes (p<0.0001) in G H animals. Also, no significant difference between the groups as for collagen fibers (p=0.0536) was observed.
  
  
  CONCLUSIONS
  The silicone membrane promoted granulation tissue with a large number of neovessels, fibroblasts and greater thickness.
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Julio Mesquita Filho, UNESP.
authors.forename: Eduardo Carlos da Silveira
authors.initials: EC
authors.lastname: Mendes
authors.forename: Fausto
authors.initials: F
authors.lastname: Viterbo
authors.forename: Celina Santaella
authors.initials: CS
authors.lastname: Rosa
mesh_terms: D000818:Animals; D001458:Bandages; D047070:Bandages, Hydrocolloid; D015992:Body Mass Index; D002056:Burns / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000737:chemistry; D006097:Granulation Tissue / Q000187:drug effects*; D007249:Inflammation; D008297:Male; D008566:Membranes; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000737:chemistry / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D012828:Silicones