Applicability of current bovine spongiform encephalopathy (BSE) diagnostic procedures for chronic wasting disease (CWD).
Chronic wasting disease (CWD) in cervids is one of the transmissible spongiform encephalopathies ; however, its risk to humans is still obscure. An increase in number of diseased deer in North America has raised concerns regarding the CWD risk to humans. We demonstrated that the con-firmatory procedures and the commercial diagnostic kits for bovine spongiform encephalopathy (BSE) can be adopted for the diagnosis of CWD. No CWD case was confirmed in the surveillance of 558 cervids that were examined between 2003 and 2006 in Japan.
Masujin
Kentaro
K
Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.
Shimada
Kimi
K
Kimura
Kumiko M
KM
Imamura
Morikazu
M
Yoshida
Ayumu
A
Iwamaru
Yoshifumi
Y
Mohri
Shirou
S
Yokoyama
Takashi
T
D000818:Animals; D000835:Animals, Wild; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003670:Deer; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry / Q000379:methods; D007564:Japan; D018620:PrPSc Proteins / Q000032:analysis*; D011933:Reagent Kits, Diagnostic; D034081:Wasting Disease, Chronic / Q000175:diagnosis*
D018620:PrPSc Proteins; D011933:Reagent Kits, Diagnostic