title: Feasibility study of postoperative intraperitoneal hyperthermochemotherapy by radiofrequency capacitive heating system for advanced gastric cancer with peritoneal seeding.
abstract: BACKGROUND
  Gastric carcinoma patients with peritoneal dissemination have an extremely poor prognosis. Attempting to improve regional control and decrease the risk of complications related to hyperthermic chemotherapy, we applied a new treatment modality using a combination of gastrectomy with postoperative intraperitoneal hyperthermo-chemotherapy (PIHC) using Thermotron RF-8. The purpose of this study was to evaluate the feasibility of PIHC in advanced gastric carcinoma patients with peritoneal seeding.
  
  
  METHODS
  Between March 2002 and April 2006, 20 gastric carcinoma patients with peritoneal dissemination were allocated to two groups in the patient's selection. The PIHC group (10 patients) received a 60-min PIHC with a cisplatin dose of 80 mg/m2 two weeks after surgery, and the control group (10 patients) received surgery alone. Thermotron RF-8 is a heating device that can raise temperatures in both superficial and deep-seated tumours using 8 MHz radiofrequency electromagnetic waves as a source of heat.
  
  
  RESULTS
  No patients in either group had life-threatening complications. The most frequent nonhaematologic toxicity (grade 3) was nausea. The one-, two-, and three-year cumulative survival rates for the PIHC group were 60%, 48%, and 36%, respectively, whereas those for the control group were 40%, 10%, and 0%, respectively. The survival rates for the PIHC group were significantly higher than those for the control group.
  
  
  CONCLUSIONS
  Although this study was conducted non-randomly with a small number of patients, the PIHC group had a higher survival rate and better prognosis compared with the control group.
authors.affiliation: Gunma University, General Surgical Science, Maebashi, Japan. emochiki@showa.gunma-u.ac.jp
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Mariko
authors.initials: M
authors.lastname: Shioya
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Sakurai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Andoh
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohno
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Aihara
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D016022:Case-Control Studies; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D004358:Drug Therapy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005743:Gastrectomy; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*; D000078702:Radiofrequency Therapy; D013274:Stomach Neoplasms / Q000601:surgery / Q000628:therapy*