The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs.
OBJECTIVE
The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection as a protection agent against cisplatin-induced ototoxicity.


METHODS
The four groups of guinea pigs were injected as follows: 1) cisplatin, 2) intratympanic dexamethasone, 3) cisplatin following intratympanic dexamethasone, and 4) cisplatin after intratympanic saline. Before and 3 days following injections, the ototoxic effect was measured with distortion product otoacoustic emissions (DPOAEs).


RESULTS
The DPOAEs amplitudes and signal-to-noise ratio (SNR) values at 1 to 6 kHz frequencies for group 1 animals after injections significantly decreased over those before injections (P < 0.05). In group 2, there were no significant differences in DPOAE amplitude and SNR values between before and after intratympanic dexamethasone injections (P > 0.05). Considering group 3, there were also no significant differences in DPOAEs amplitudes and SNR values before and after of dexamethasone and cisplatin injections (P > 0.05).


CONCLUSIONS
Intratympanic dexamethasone injection did not cause any ototoxic effect; in contrast, it might have a significant protective effect after cisplatin injection.
Daldal
Alper
A
Department of Otorhinolaryngology, Acipayam Goverment Hospital, Denizli, Turkey.
Odabasi
Onur
O
Serbetcioglu
Bulent
B
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D006312:Hearing Loss, Bilateral / Q000139:chemically induced* / Q000517:prevention & control*; D007267:Injections; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D014432:Tympanic Membrane
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D002945:Cisplatin