title: Epiphyseal expansion in hand bones: association with age, sex, and hand osteoarthritis.
abstract: OBJECTIVE
  Previous studies showed increased femoral, neck, and tibial plateau with age in individuals with and without osteoarthritis (OA) at adjacent joints. However, the question whether epiphyseal bone enlargement is a natural phenomenon of aging or associated with OA remains open. The aim of the present study was to evaluate age- and sex-related changes in the relative size of epiphyses of long hand bones and their association with radiographic OA.
  
  
  METHODS
  The data were collected from a population-based European sample in 1994 (557 individuals) and in 2002 (513 individuals). The latter sample included 253 individuals who were previously investigated in 1994. The epiphyseal index (EI), reflecting the relative size of bone epiphyses and hand OA, was evaluated from hand radiographs. Statistical analyses included multiple regression analyses and a maximum likelihood-based model-fitting technique.
  
  
  RESULTS
  Hand bone epiphyses increased with age and with OA. In males, the EI gradually increased during their entire life span. In females, the EI remained almost unchanged up to the age of 40, after which, it increased more rapidly than in males. Individuals with OA had higher values of EI at any age. In both sexes, epiphyseal enlargement is a predisposing factor for hand OA progression in adjacent joints. This was clearly seen in males, where old individuals with high EI values had much higher OA scores in comparison with age-matched individuals.
  
  
  CONCLUSIONS
  Enlargement of long bone epiphyses with age appears to be a general tendency in the human skeleton. Our study shows that the enlargement of epiphyses may also be related to OA.
authors.affiliation: Department of Physical Therapy, The Stanley Steyer School of Health Professions, Tel Aviv University, Tel Aviv, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Kalichman
authors.forename: I
authors.initials: I
authors.lastname: Malkin
authors.forename: M J
authors.initials: MJ
authors.lastname: Seibel
authors.forename: E
authors.initials: E
authors.lastname: Kobyliansky
authors.forename: G
authors.initials: G
authors.lastname: Livshits
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004838:Epiphyses / Q000473:pathology; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D050276:Hand Bones / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D012737:Sex Factors