Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery.
OBJECTIVE
To investigate how the mode of delivery affects the level oxidative stress in newborns.


METHODS
15-F(2t)-isoprostane, as index of oxidative stress, was measured in umbilical cord plasma samples from 37 infants born after vaginal delivery or caesarian section, using specific immuno-affinity extraction and immunoassay.


RESULTS
15-F(2t)-isoprostane levels were higher in infants born after vaginal delivery (n=18) compared to those delivered by elective caesarian section (n=19).


CONCLUSIONS
15-F(2t)-isoprostane is a sensitive biomarker of fetal oxidative stress during labor.
Greco
Anita
A
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena, 299-00161 Rome, Italy. anita.greco@iss.it
Minghetti
Luisa
L
Puopolo
Maria
M
Pietrobon
Beatrice
B
Franzoi
Malida
M
Chiandetti
Lino
L
Suppiej
Agnese
A
D001034:Apgar Score; D015415:Biomarkers / Q000097:blood; D036861:Delivery, Obstetric / Q000379:methods*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D012680:Sensitivity and Specificity
D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost