Computational modeling of Abeta fiber wind-up.
Wind-up, a condition related to chronic pain, is described traditionally as a frequency dependent increase in the excitability of sensory spinal cord neurons, evoked by electrical stimulation of small pain fibers. In this paper, we introduce a computational model on wind-up of large (Abeta) fibers, considering three major mechanisms of wind-up: 1) a feedforward mechanism causing Ca2+ entry, 2) a positive feedback, causing more Ca2+ entry, and 3) a feedforward due to sprouting of Abeta fibers towards the small pain fibers. Our model proposes three different ways for reducing wind-up and shows the most important way to treat the pain.
Farajidavar
Aydin
A
Neuromuscular Syst. Lab., Fac. of Biomed. Eng., Amirkabir Univ. of Technol., Hafez, Tehran, Iran. farajidavar@aut.ac.ir
Towhidkhah
Farzad
F
Mirhashemi
Arash
A
Gharibzadeh
Shahriar
S
Behbehani
Khosrow
K
D016229:Amyloid beta-Peptides / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D003198:Computer Simulation; D003201:Computers; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008962:Models, Theoretical; D009474:Neurons / Q000473:pathology*; D010146:Pain; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012984:Software; D013116:Spinal Cord / Q000473:pathology*; D013997:Time Factors
D016229:Amyloid beta-Peptides; D015220:Calcium Channels; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium