title: Neuroglobin: an endogenous neuroprotectant.
abstract: Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic-ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces--and knocking down Ngb expression increases--hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.
authors.affiliation: Buck Institute for Age Research, Novato, CA 94549, USA. dgreenberg@buckinstitute.org
authors.forename: David A
authors.initials: DA
authors.lastname: Greenberg
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
authors.forename: Adil A
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000818:Animals; D005914:Globins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000517:prevention & control*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000517:prevention & control*; D000078787:Neuroglobin; D018696:Neuroprotective Agents; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D005914:Globins