Mathematical modeling and analysis of force induced bone growth.
Bone is a dynamic living tissue that undergoes continuous adaptation of its mass and structure in response to mechanical and biological environment demands. Studies of bone adaptation have focused on metabolic or mechanical stimulus, but mathematical models of bone adaptation considering both, are not available by now. In this paper, we propose a mathematical model of bone adaptation during a remodeling cycle due to mechanical stimulus with the introduction of osteocytes as mechanotransducers. The model captures qualitatively very well the bone adaptation and cell interactions during the bone remodeling.
Maldonado
Solvey
S
Inst. for Syst. Theor. & Autom. Control, Stuttgart, Germany. maldonado@ist.uni-stuttgart.de
Borchers
Steffen
S
Findeisen
Rolf
R
Allgöwer
Frank
F
D000222:Adaptation, Physiological; D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D016723:Bone Remodeling / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology; D005246:Feedback; D006801:Humans; D008433:Mathematics; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D010011:Osteocytes / Q000502:physiology; D053244:Osteoprotegerin / Q000502:physiology; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology; D013314:Stress, Mechanical
D053244:Osteoprotegerin; D053246:Receptor Activator of Nuclear Factor-kappa B; D015232:Dinoprostone