EMG-based detection of inspiration in the rat diaphragm muscle.
An algorithm to detect the timing of each breath from an electromyogram (EMG) signal was developed. The algorithm has low computation cost and would be suitable for applications of implantable diaphragm pacing devices or as a trigger for each breath generated by a mechanical ventilator. The algorithm was implemented both in a Lab View program on a desktop computer and in a C program on a microcontroller chip, and was tested on the EMG signal from the left diaphragm muscle of an anesthetized rat via implanted electrodes. The breath detection by the algorithm was over 99% accurate when the anesthetized rat was lying still, but for periods when the rat was gently wiggled to introduce noise and irregular breathing patterns, 19% of the breaths were missed and false positives occurred 6% of the time.
Dow
Douglas E
DE
Departmernt of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. dow.douglas@mayo.edu
Mantilla
Carlos B
CB
Zhan
Wen-Zhi
WZ
Sieck
Gary C
GC
D000465:Algorithms; D000818:Animals; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003964:Diaphragm / Q000502:physiology*; D004576:Electromyography / Q000379:methods*; D001239:Inhalation / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D012680:Sensitivity and Specificity