title: Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides.
abstract: Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation.
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Gangadhar
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Jeyakani
authors.forename: M S
authors.initials: MS
authors.lastname: Shaila
authors.forename: Rabindranath
authors.initials: R
authors.lastname: Nayak
authors.forename: Nagasuma
authors.initials: N
authors.lastname: Chandra
mesh_terms: D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry* / Q000276:immunology; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000737:chemistry* / Q000276:immunology; D019295:Computational Biology; D000939:Epitopes; D005805:Genes, MHC Class I / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000737:chemistry; D007156:Immunologic Memory; D008958:Models, Molecular; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000956:Antigens, Viral; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D007135:Immunoglobulin Variable Region; D010455:Peptides