title: A portable needle-free jet injector based on a custom high power-density voice-coil actuator.
abstract: We have constructed a portable needle-free drug injection (NFI) device based upon a custom voice-coil linear actuator. Our actuator is optimized to provide high instantaneous force (>200 N) and power (4 kW) while still allowing a total stroke of 25 mm. The actuator is relatively inexpensive, compact, and lightweight, allowing it to serve as the force generator in a portable, reusable, handheld NFI system. The actuator is capable of accelerating liquid drug in quantities of up to 250 microL to a speed of more than 200 ms(-1). The repeatability of a 50 microL volume ejection is better than +/-1 microL.
authors.affiliation: Bioinstrumentation Lab, Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. taberner@mit.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Taberner
authors.forename: Nathan B
authors.initials: NB
authors.lastname: Ball
authors.forename: N Catherine
authors.initials: NC
authors.lastname: Hogan
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hunter
mesh_terms: D004396:Coloring Agents / Q000494:pharmacology; D016503:Drug Delivery Systems; D011211:Electric Power Supplies; D004867:Equipment Design; D007277:Injections, Jet; D007279:Injections, Subcutaneous; D008280:Magnetics; D015233:Models, Statistical; D009339:Needles; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012869:Skin Absorption; D013594:Syringes; D014831:Voice
chemical_list: D004396:Coloring Agents