Change of coagulation parameters after double plateletpheresis.
In the previous studies, some authors reported that automated apheresis leads to a hypercoagulable state. We tried to find out changes in coagulation parameters after double plateletpheresis in this study. Forty-five donors were recruited to the study, and coagulation parameters were assessed before and after double plateletpheresis. After double plateletpheresis, fibrinogen, factor V, factor VIII and factor IX were decreased compared with the values before apheresis. Although serum levels of this coagulation parameters are decreasing, they are still in the normal limits. Therefore, we suggest that double plateletpheresis is a safe procedure for healthy volunteers taking into account these coagulation parameters.
Yilmaz
Mustafa
M
Department of Hematology, Karadeniz Technical University Hospital, Trabzon, Turkey. myilmaz1971@yahoo.com
Dikmen
Tamer
T
Sonmez
Mehmet
M
Akdogan
Elif
E
Durmus
Ahmet
A
Omay
Serdar Bedii
SB
Ovali
Ercument
E
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001782:Blood Donors; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010983:Plateletpheresis / Q000009:adverse effects / Q000379:methods*; D012016:Reference Values; D012449:Safety
D005165:Factor V; D005169:Factor VIII; D005164:Factor IX; D005340:Fibrinogen