Ectodomain shedding of receptor activator of NF-kappaB ligand.
Receptor activator of NF-kappab ligand (RANKL), a key regulator of osteoclastogenesis, is proteolytically processed and converted to a soluble form. RANKL sheddase and the biologic and pathologic role of RANKL shedding have been undetermined, but the identity of sheddase and its effect on osteoclastogenesis are gradually clarified. The regulatory mechanism and its relevance to some pathologic conditions are to be elucidated.
Hikita
Atsuhiko
A
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihata National Hospital, Tokyo, Japan. a-hikita@sagamihara-hosp.gr.jp
Tanaka
Sakae
S
D000818:Animals; D002460:Cell Line; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D010006:Osteoblasts / Q000201:enzymology / Q000378:metabolism; D010010:Osteoclasts / Q000201:enzymology / Q000502:physiology*; D010012:Osteogenesis; D053244:Osteoprotegerin / Q000378:metabolism; D012516:Osteosarcoma / Q000201:enzymology / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism*
D016328:NF-kappa B; D053244:Osteoprotegerin; D053245:RANK Ligand; D053504:Matrix Metalloproteinases, Membrane-Associated