title: Antimicrobial profiles of Prevotella spp. and Fusobacterium nucleatum isolated from periodontal infections in a selected area of southern Italy.
abstract: In view of the increasing antibiotic resistance of anaerobic Gram-negative bacteria, we determined the antimicrobial profile of 55 periodontal anaerobic Gram-negative bacteria correlated with human infections, comprising 16 strains of Fusobacterium nucleatum and 39 strains of Prevotella spp. isolated from periodontal pockets of 26 adults suffering from chronic periodontitis. All the strains of F. nucleatum were susceptible to amoxicillin/clavulanic acid, doxycycline, metronidazole, moxifloxacin and levofloxacin, whilst 2/16 strains were both resistant to amoxicillin and beta-lactamase-positive and 11/16 were resistant to clarithromycin. All of the Prevotella strains were susceptible to amoxicillin/clavulanic acid, doxycycline and metronidazole, whereas 7/39 strains were beta-lactamase-positive and resistant to amoxicillin, 5/39 were resistant to clarithromycin and 3/39 were resistant to both moxifloxacin and levofloxacin. Our findings confirm that there is an increasing need to encourage practitioners to use laboratory investigations to limit the risk of an incorrect therapeutic approach and to avoid the overuse of antimicrobial agents.
authors.affiliation: Università di Bari, Bari, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Mosca
authors.forename: Luisa
authors.initials: L
authors.lastname: Miragliotta
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Iodice
authors.forename: Antonia
authors.initials: A
authors.lastname: Abbinante
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Miragliotta
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016866:Bacteroidaceae Infections / Q000453:epidemiology / Q000382:microbiology; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005674:Fusobacterium Infections / Q000453:epidemiology / Q000382:microbiology; D016967:Fusobacterium nucleatum / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D010518:Periodontitis / Q000453:epidemiology* / Q000382:microbiology*; D018720:Prevotella / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents