title: Bio-heat transfer model of deep brain stimulation induced temperature changes.
abstract: There is a growing interest in the use of chronic deep brain stimulation (DBS) for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. Fundamental questions remain about the physiologic effects and safety of DBS. Previous basic research studies have focused on the direct polarization of neuronal membranes by electrical stimulation. The goal of this paper is to provide information on the thermal effects of DBS using finite element models to investigate the magnitude and spatial distribution of DBS induced temperature changes. The parameters investigated include: stimulation waveform, lead selection, brain tissue electrical and thermal conductivity, blood perfusion, metabolic heat generation during the stimulation. Our results show that clinical deep brain stimulation protocols will increase the temperature of surrounding tissue by up to 0.8 deg C depending on stimulation/tissue parameters.
authors.affiliation: Dept. of Biomed. Eng., City Coll. of New York, NY 10031, USA. melwassif@eartlink.net
authors.forename: Maged M
authors.initials: MM
authors.lastname: Elwassif
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Kong
authors.forename: Maribel
authors.initials: M
authors.lastname: Vazquez
authors.forename: Marom
authors.initials: M
authors.lastname: Bikson
mesh_terms: D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010477:Perfusion; D013696:Temperature; D013816:Thermodynamics