Chromosome orientation.
Precise chromosome segregation during cell division results from the attachment of chromosomes to microtubules emanating from both poles of the spindle apparatus. The molecular machinery involved in establishing and maintaining properly oriented microtubule attachments remains murky. Some clarity is now emerging with the identification of Bod1 (Biorientation Defective 1), a protein that promotes chromosome biorientation by unleashing chromosomes from improperly oriented microtubule attachments.
Compton
Duane A
DA
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. Duane.c.compton@dartmouth.edu
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism; D045584:Chromosome Positioning; D006367:HeLa Cells; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D010641:Phenotype; D010766:Phosphorylation; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D014981:Xenopus / Q000378:metabolism; D029867:Xenopus Proteins / Q000378:metabolism
D018797:Cell Cycle Proteins; C091489:KIF2C protein, human; D034741:RNA, Small Interfering; D029867:Xenopus Proteins; D016547:Kinesins