title: [Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine].
abstract: The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.
authors.affiliation: Instituto Finlay, Ciudad de La Habana, Cuba.
authors.forename: José Daniel Benítez
authors.initials: JD
authors.lastname: Zamora
authors.forename: Kenia Fernández
authors.initials: KF
authors.lastname: Enrique
authors.forename: Raúl Gutiérrez
authors.initials: RG
authors.lastname: Boué
authors.forename: Florinda Hernández
authors.initials: FH
authors.lastname: Torres
authors.forename: Janet Lazo
authors.initials: JL
authors.lastname: Airado
authors.forename: Damián Rojo
authors.initials: DR
authors.lastname: Hernández
mesh_terms: D001428:Bacterial Vaccines / Q000191:economics / Q000592:standards; D001431:Bacteriological Techniques; D005285:Fermentation; D006801:Humans; D041341:Leptospira interrogans serovar canicola / Q000276:immunology* / Q000378:metabolism*; D007922:Leptospirosis / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D001428:Bacterial Vaccines