title: Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease.
abstract: OBJECTIVE
  To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review.
  
  
  RESULTS
  Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients (p < 0.0013, p < 0.00015, p < 0.0008, respectively).
  
  
  CONCLUSIONS
  SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.
authors.affiliation: Department of Ophthalmology, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Mizuka
authors.initials: M
authors.lastname: Kamoi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Miki
authors.initials: M
authors.lastname: Uchino
authors.forename: Motoko
authors.initials: M
authors.lastname: Kawashima
authors.forename: Eiki
authors.initials: E
authors.lastname: Goto
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D002908:Chronic Disease; D002921:Cicatrix / Q000473:pathology; D015352:Dry Eye Syndromes / Q000209:etiology / Q000503:physiopathology; D005128:Eye Diseases / Q000150:complications*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000503:physiopathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000209:etiology* / Q000473:pathology; D008297:Male; D008537:Meibomian Glands / Q000503:physiopathology; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index