Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones.
A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox.
Foroumadi
Alireza
A
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
Samzadeh-Kermani
Alireza
A
Emami
Saeed
S
Dehghan
Gholamreza
G
Sorkhi
Maedeh
M
Arabsorkhi
Fatemeh
F
Heidari
Mahmoud Reza
MR
Abdollahi
Mohammad
M
Shafiee
Abbas
A
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010851:Picrates; D013329:Structure-Activity Relationship
D000975:Antioxidants; D001597:Benzylidene Compounds; D001713:Biphenyl Compounds; D002839:Chromans; D005290:Ferric Compounds; D005609:Free Radicals; D006834:Hydrazines; D008055:Lipids; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid