[Annexin in mineralization process].
Annexins are necessary for mineralization process. They seem to play a major role in regulation of cells competent in mineralization as well as in direct formation of mineral phase in the extracellular matrix. Their ability to accommodate to different functions in different cellular compartments is associated with their property to bind to biological membranes in a lipid- and Ca2+-dependent and independent manners. The aim of this review is to describe potential functions of the annexin family of proteins in a mineralization process with special emphasis to structure-function relationships of annexins.
Sekrecka
Anna
A
Zakład Biochemii Komórki, Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego, Warszawa.
Balcerzak
Marcin
M
Thouverey
Cyril
C
Buchet
Rene
R
Pikula
Sławomir
S
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D017302:Annexins / Q000502:physiology*; D001857:Bone Matrix / Q000378:metabolism; D001842:Bone and Bones / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D019902:Chondrocytes / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006132:Growth Plate / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry* / Q000302:isolation & purification; D008854:Microscopy, Electron; D010758:Phosphorus / Q000378:metabolism
D017302:Annexins; D008563:Membrane Lipids; D008565:Membrane Proteins; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium