[Association between serotonin 1D gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid learning disorder].
OBJECTIVE
To investigate the relationship between two HTR1D gene polymorphisms, 1350T>C and 1236A>G polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid learning disorder (LD).


METHODS
Blood samples were taken from 91 trios with probands of ADHD comorbid LD and 181 trios with probands of ADHD not comorbid LD. DNA was extracted. 1350T>C and 1236A>G were genotyped by restriction fragment length polymorphism analysis. Transmit/disequilibrium test and haplotype analysis were used to test the association between the two polymorphisms of HTR1D gene and ADHD comorbid or not comorbid LD separately.


RESULTS
1236A allele (chi2=5.306, P=0.021) was over transmitted to probands of ADHD without LD. No biased transmissions of any allele and haplotype were found in families with probands of ADHD with LD.


CONCLUSIONS
whether ADHD comorbid LD or not comorbid LD makes difference at the level of HTR1D gene polymorphism of 1236A>G.
Li
Jun
J
Institute of Mental Health, Peking University, Beijing 100083, China.
Wang
Yu feng
Yf
Zhou
Ru-lun
RL
Yang
Li
L
Zhang
Hao-bo
HB
Wang
Bing
B
D000293:Adolescent; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007859:Learning Disabilities / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics*
D044346:Receptor, Serotonin, 5-HT1D