title: Pyrene modification leads to increased catalytic activity in minimal hammerhead ribozymes.
abstract: Highly active variants of minimal hammerhead ribozymes are generated by the replacement of substantial parts of stem-loop structures with pyrene building blocks.
authors.affiliation: University of Konstanz, Department of Chemistry, Universitätsstr. 10, 78457, Konstanz, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Looser
authors.forename: Simon M
authors.initials: SM
authors.lastname: Langenegger
authors.forename: Robert
authors.initials: R
authors.lastname: Häner
authors.forename: Jörg S
authors.initials: JS
authors.lastname: Hartig
mesh_terms: D002384:Catalysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011721:Pyrenes / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D016337:RNA, Catalytic / Q000737:chemistry*
chemical_list: D011721:Pyrenes; D016337:RNA, Catalytic; C427204:hammerhead ribozyme; D012313:RNA