title: [Organ procurement and transplantation from non-heart-beating donors].
abstract: Despite a significant increase in procurement and transplantation activities observed in France in the last eight years, the shortage in grafts is on the rise and demand keeps being much higher than supply. Since 1968 and until now, procurement was limited to heart beating brain donors. The results of kidneys transplanted from non-heart-beating donors have significantly improved and are nowadays comparable to those of kidney transplantations from brain death donors, thanks to a more accurate selection of donors and recipients, to better respect of preventing cold and warm ischemia times and to several major therapeutic innovations. Procurement on non-heart-beating donors are therefore being reconsidered under considerations of feasibility, results and ethical and legal consequences, under a specific medical protocol issued by the agency of biomedicine with the pilot hospital center agreement to comply with the protocol. Referring to foreign experiences, this program is likely to decrease the organ shortage, which is jeopardizing the treatment of a large number of patients awaiting transplantation.
authors.affiliation: Direction médicale et scientifique, agence de la biomédecine, 93212 Saint-Denis-la-Plaine cedex, France. corinne.antoine@biomedicine.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Antoine
authors.forename: Frédéric
authors.initials: F
authors.lastname: Brun
authors.forename: Alain
authors.initials: A
authors.lastname: Tenaillon
authors.forename: Bernard
authors.initials: B
authors.lastname: Loty
mesh_terms: D016757:Death, Sudden, Cardiac; D006801:Humans; D016030:Kidney Transplantation; D009927:Tissue and Organ Procurement / Q000941:ethics / Q000331:legislation & jurisprudence / Q000379:methods*