title: Protective immunity against plague.
abstract: Plague, an infectious disease that reached catastrophic proportions during three pandemics, continues to be a legitimate public health concern worldwide. Although antibiotic therapy for the causative agent Yersinia pestis is available, pharmaceutical supply limitations, multi-drug resistance from natural selection as well as malicious bioengineering are a reality. Consequently, plague vaccinology is a priority for biodefense research. Development of a multi-subunit vaccine with Fraction 1 and LcrV as protective antigens seems to be receiving the most attention. However, LcrV has been shown to cause immune suppression and Y. pestis mutants lacking F1 expression are thought to be fully virulent in nature and in animal experiments. The LcrV variant, rV10, retains the well documented protective antigenic properties of LcrV but with diminished inhibitory effects on the immune system. More research is required to examine the molecular mechanisms of vaccine protection afforded by surface protein antigens and to decipher the host mechanisms responsible for vaccine success.
authors.affiliation: Department of Microbiology, University of Chicago, IL, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Cornelius
authors.forename: Lauriane
authors.initials: L
authors.lastname: Quenee
authors.forename: Deborah
authors.initials: D
authors.lastname: Anderson
authors.forename: Olaf
authors.initials: O
authors.lastname: Schneewind
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D010861:Fimbriae, Bacterial / Q000276:immunology; D014943:Global Health; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010930:Plague / Q000266:history / Q000276:immunology* / Q000517:prevention & control*; D010931:Plague Vaccine / Q000266:history / Q000302:isolation & purification; D012106:Research / Q000266:history; D022223:Vaccines, Subunit / Q000266:history / Q000302:isolation & purification; D015010:Yersinia pestis / Q000276:immunology / Q000472:pathogenicity
chemical_list: D001425:Bacterial Outer Membrane Proteins; D010931:Plague Vaccine; D022223:Vaccines, Subunit