title: A realistic spatiotemporal source model for EEG activity: application to the reconstruction of epileptic depth-EEG signals.
abstract: The context of this work is the interpretation of depth-EEG signals recorded in epileptic patients. This study focuses on the relationship between spatial and temporal properties of neuronal sources and depth-EEG signals observed along intracerebral electrodes (source/sensor relationship). We developed an extended source model which connects two levels of representation: a model of coupled neuronal populations and a distributed current dipole model. This model was used to simulate epileptic spiking depth-EEG signals from the forward solution at each intracerebral sensor location. Results showed that realistic spikes were obtained in the model under two specific conditions: a sufficiently large spatial extension of the neocortical source and a high degree of coupling between activated neuronal populations composing this extended source.
authors.affiliation: LTSI INSERM, Rennes I Univ. delphine.cosandier-rimele@univ-rennes1.fr
authors.forename: D
authors.initials: D
authors.lastname: Cosandier-Rimélé
authors.forename: J M
authors.initials: JM
authors.lastname: Badier
authors.forename: F
authors.initials: F
authors.lastname: Wendling
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D001931:Brain Mapping; D003198:Computer Simulation; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008959:Models, Neurological; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology