title: Investigating the protective effect of melatonin on liver injury related to myocardial ischemia-reperfusion.
abstract: BACKGROUND
  An animal model of myocardial ischemia-reperfusion (MI/R) was used to test the hypothesis that free radicals released with MI/R have hazardous effects on liver through remote organ injury.
  
  
  METHODS
  Twenty-one rats were divided into three groups: sham-treated, MI/R, and MI/R+melatonin. To produce MI/R, a branch of the left coronary artery was occluded for 30 min followed by two hours of reperfusion. Melatonin or vehicle was given 10 min before ischemia. At the end of the study, liver tissue was obtained for biochemical determination. The false discovery rate (FDR) is explained and was used for multiple comparisons of the groups' means.
  
  
  RESULTS
  Compared with the sham group, MI/R significantly decreased glutathione (GSH) content and increased levels of nitric oxide (NO) and malondialdehyde (MDA). Melatonin administration significantly increased GSH levels and decreased the levels of NO and MDA compared with the MI/R group.
  
  
  CONCLUSIONS
  Melatonin could prevent liver damage due to its strong antioxidant and free radical scavenger effects. Therefore, melatonin may have beneficial effects on remote organ injury such as MI/R-induced liver disorders.
authors.affiliation: Turkish Standards Institution (TSE), Ankara, Turkey. cemilcolak@yahoo.com
authors.forename: Cemil
authors.initials: C
authors.lastname: Colak
authors.forename: Hakan
authors.initials: H
authors.lastname: Parlakpinar
authors.forename: Mehmet Kaya
authors.initials: MK
authors.lastname: Ozer
authors.forename: Engin
authors.initials: E
authors.lastname: Sahna
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Cigremis
authors.forename: Ahmet
authors.initials: A
authors.lastname: Acet
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000627:therapeutic use*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione; D008550:Melatonin