Control of cell cycle and cell growth by molecular chaperones.
Cells adapt their size to both intrinsic and extrinsic demands and, among them, those that stem from growth and proliferation rates are crucial for cell size homeostasis. Here we revisit mechanisms that regulate cell cycle and cell growth in budding yeast. Cyclin Cln3, the most upstream activator of Start, is retained at the endoplasmic reticulum in early G(1) and released by specific chaperones in late G(1) to initiate the cell cycle. On one hand, these chaperones are rate-limiting for release of Cln3 and cell cycle entry and, on the other hand, they are required for key biosynthetic processes. We propose a model whereby the competition for specialized chaperones between growth and cycle machineries could gauge biosynthetic rates and set a critical size threshold at Start.
Aldea
Martí
M
Departament de Ciències Mèdiques Bàsiques, IRBLLEIDA, Universitat de Lleida, Lleida, Catalonia, Spain. marti.aaldea@cmb.udl.cat
Garí
Eloi
E
Colomina
Neus
N
D002453:Cell Cycle / Q000502:physiology*; D049108:Cell Enlargement; D049109:Cell Proliferation; D018832:Molecular Chaperones / Q000502:physiology*; D004718:Saccharomycetales / Q000166:cytology* / Q000254:growth & development* / Q000502:physiology
D018832:Molecular Chaperones