title: Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland.
abstract: Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected.
authors.affiliation: Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany. bernhard.greve@uni-tuebingen.de
authors.forename: Bernhard
authors.initials: B
authors.lastname: Greve
authors.forename: Rostislav
authors.initials: R
authors.lastname: Simonenko
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Illes
authors.forename: Agnes
authors.initials: A
authors.lastname: Peterfalvi
authors.forename: Nada
authors.initials: N
authors.lastname: Hamdi
authors.forename: Marcin P
authors.initials: MP
authors.lastname: Mycko
authors.forename: Krzysztof W
authors.initials: KW
authors.lastname: Selmaj
authors.forename: Csilla
authors.initials: C
authors.lastname: Rozsa
authors.forename: Katalin
authors.initials: K
authors.lastname: Rajczy
authors.forename: Peter
authors.initials: P
authors.lastname: Bauer
authors.forename: Klaus
authors.initials: K
authors.lastname: Berger
authors.forename: Robert
authors.initials: R
authors.lastname: Weissert
mesh_terms: D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D060908:CTLA-4 Antigen; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D006814:Hungary; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*; D011044:Poland; D011110:Polymorphism, Genetic
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human