title: Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg.
abstract: Segmentation plays crucial roles during morphogenesis. Drosophila legs are divided into segments along the proximal-distal axis by flexible structures called joints. Notch signaling is necessary and sufficient to promote leg growth and joint formation, and is activated in distal cells of each segment in everting prepupal leg discs. The homeobox gene defective proventriculus (dve) is expressed in regions both proximal and distal to the intersegmental folds at 4 h after puparium formation (APF). Dve-expressing region partly overlaps with the Notch-activated region, and they become a complementary pattern at 6 h APF. Interestingly, dve mutant legs resulted in extra joint formation at the center of each tarsal segment, and the forced expression of dve caused a jointless phenotype. We present evidence that Dve suppresses the potential joint-forming activity, and that Notch signaling represses Dve expression to form joints.
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shirai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yorimitsu
authors.forename: Naruto
authors.initials: N
authors.lastname: Kiritooshi
authors.forename: Fumio
authors.initials: F
authors.lastname: Matsuzaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakagoshi
mesh_terms: D000818:Animals; D016764:Cell Polarity; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000378:metabolism*; D007596:Joints / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D051880:Receptors, Notch; C114494:dve protein, Drosophila; D066246:ErbB Receptors