title: Primary invasive versus progressive invasive transitional cell bladder cancer: multicentric study of overall survival rate.
abstract: OBJECTIVE
  When feasible, the treatment for all-invasive bladder cancer is radical cystectomy. The aim of the present study was to analyze the prognostic difference, disease-specific survival rate, of muscle-invasive transitional cell cancer of the bladder (TCCB) for progressive invasive TCCB.
  
  
  METHODS
  A retrospective multicentric analysis was performed studying a total of 242 patients who underwent radical cystectomy for invasive TCCB from 1993 to 2005. The patients were divided into two groups: group 1 included 57 patients with progressive invasive TCCB, and group 2 included 185 patients with primary invasive TCCB. Both groups were further divided according to the pathological findings in pT2/3 (muscle and/or perivesical fat invasion), pT4 (adjacent organs/structure invasion), N+ (positive lymphatic nodes) and M+ (distant organ metastasis). Several tests were employed for statistical analysis: chi2, Mann-Whitney, Kaplan-Meier method and Wilcoxon (Breslow) method were used to compare the possible survival curve differences of groups 1 and 2. Multivariated analysis determined by proportional risk regression excluded sex, age and disease stage interferences in the final results.
  
  
  RESULTS
  The average time for a superficial TCCB to become muscle-invasive was 37.4 months, and the average number of transurethral resections performed in each patient was 3. The average and median global survival rates were, respectively, 96 and 88 months in group 1 and 98 and 90 months in group 2, without a statistically significant difference (p = 0.0734). The 1-year survival rate was 84.32% in group 1 and 76.54% in group 2. After 3 years of follow-up the survival rate fell to 74.50% in group 1 and to 59.05% in group 2. Finally, the 5-year survival rate was 57.94% in group 1 and 52.24% in group 2.
  
  
  CONCLUSIONS
  In the present study, patients with primary invasive and progressive invasive TCCB showed a similar 5-year disease-specific survival rate. Pathological stage (pTN, N and M) and patient demography did not interfere with the results.
authors.affiliation: Division of Urology UNICAMP, São Paulo, Brazil.
authors.forename: Ubirajara
authors.initials: U
authors.lastname: Ferreira
authors.forename: Wagner Eduardo
authors.initials: WE
authors.lastname: Matheus
authors.forename: Renato
authors.initials: R
authors.lastname: Nardi Pedro
authors.forename: Carlos Alturo
authors.initials: CA
authors.lastname: Levi D'Ancona
authors.forename: Leonardo Oliveira
authors.initials: LO
authors.lastname: Reis
authors.forename: Rafael Mamprin
authors.initials: RM
authors.lastname: Stopiglia
authors.forename: Fernandes
authors.initials: F
authors.lastname: Denardi
authors.forename: Nelson
authors.initials: N
authors.lastname: Rodrigues Netto
authors.forename: Stênio
authors.initials: S
authors.lastname: de Cássio Zequi
authors.forename: Francisco Paulo
authors.initials: FP
authors.lastname: da Fonseca
authors.forename: Ademar
authors.initials: A
authors.lastname: Lopes
authors.forename: Gustavo
authors.initials: G
authors.lastname: Cardoso Guimarães
authors.forename: Roni
authors.initials: R
authors.lastname: de Carvalho Fernandes
authors.forename: Marjo Deninson
authors.initials: MD
authors.lastname: Cardenuto Perez
mesh_terms: D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002295:Carcinoma, Transitional Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D015653:Cystectomy; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*