title: Management of persistent glaucoma secondary to depot methylprednisolone.
abstract: This article describes two patients with recalcitrant ocular hypertension persisting 6 and 4 months, respectively, after periocular injection of methylprednisolone acetate despite maximum medical therapy. White sub-Tenon's plaques of residual methylprednisolone acetate were excised surgically and analyzed for steroid activity using spectrophotometry. In both cases, intraocular pressure was normalized promptly after surgical removal of visible steroid. In both instances, biochemical analysis of the excised samples revealed residual steroid. Surgical removal of a residual methylprednisolone depot is an effective management choice in patients developing persistent intraocular pressure elevation after periocular injection.
authors.affiliation: Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Aydin
authors.forename: Tugrul
authors.initials: T
authors.lastname: Akin
authors.forename: Ahmet Hamdi
authors.initials: AH
authors.lastname: Bilge
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005901:Glaucoma / Q000139:chemically induced* / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D007267:Injections; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D013508:Ophthalmologic Surgical Procedures; D009915:Orbit; D015864:Panuveitis / Q000188:drug therapy; D015868:Pars Planitis / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone