title: Ruptured vertebrobasilar aneurysm associated with giant cell arteritis in a young boy.
abstract: Intracranial aneurysms are rare in early childhood and there is little published information on their histology. We report a young boy who died of subarachnoid haemorrhage, 29 months after coiling of a giant vertebrobasilar aneurysm. Histology of the aneurysm revealed intramural inflammation with giant cells and fragmentation of the internal elastic lamina. The findings highlight the need for detailed examination in such cases, to elucidate the pathogenesis and pathology of cerebrovascular aneurysms in this age group.
authors.affiliation: Department of Neuropathology, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK. seth.love@bris.ac.uk
authors.forename: Seth
authors.initials: S
authors.lastname: Love
authors.forename: Shelley
authors.initials: S
authors.lastname: Renowden
authors.forename: Michael
authors.initials: M
authors.lastname: Carter
mesh_terms: D017542:Aneurysm, Ruptured / Q000209:etiology* / Q000473:pathology; D001488:Basilar Artery; D002675:Child, Preschool; D017809:Fatal Outcome; D013700:Giant Cell Arteritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000473:pathology; D008297:Male; D014711:Vertebral Artery