Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field.
Somatostatin receptors (sst), somatostatin (SS) and cortistatin (CST) are widely expressed in the various systems in the human and rodent organisms and are "responsible" for maintaining homeostasis, which is essential for survival. Because of their broad expression pattern sst, SS and CST interactions may play regulatory roles in both physiology and pathophysiology in mammalian organisms. SS analogue treatment strategies as well as the use of SS analogues for diagnostic purposes have been established in diseases of different origins. This review focuses on the currently determined role for SS analogues in today's clinical practice and the potential clinical prospects for SS, CST and sst interactions in the future, with a focus on neuroendocrine and non-neuroendocrine tumours and immune-mediated diseases. Moreover, the role of new SS analogues and new insights in sst physiology will be discussed.
Dalm
V A S H
VA
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. v.dalm@erasmusmc.nl
Hofland
L J
LJ
Lamberts
S W J
SW
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D004701:Endocrine Gland Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D004700:Endocrine System Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000378:metabolism; D007154:Immune System Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism* / Q000627:therapeutic use; D009490:Neurosecretory Systems / Q000378:metabolism*; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000819:agonists / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D009479:Neuropeptides; D017481:Receptors, Somatostatin; C099323:cortistatin; D013004:Somatostatin