title: Arterial ischemic stroke in childhood: risk factors and outcome in old versus new era.
abstract: Risk factors of children with arterial ischemic stroke were retrospectively evaluated. The children were grouped according to values on developing diagnostic tools: 13 in the old era (1987-1994) and 18 in the new era (1995-2004). The old era battery included 5 tests: protein C, protein S, antithrombin, lupus anticoagulants, and anticardiolipin antibodies. The new era battery added 5 more tests: homocystine level, factor VIII level, mutations for factor V Leiden and prothrombin G20210A, and lipoprotein (a) level. At least 1 risk factor was found in 5 of 13 children (38.5%) in the old era and in 8 of 18 (44.4%) in the new era. The extended battery for prothrombotic disorders revealed 7 risk factors in 4 children (22.2%) in the new era, whereas the limited battery identified a single risk factor in 1 child (7.7%) in the old era. For the correct etiologic identification, prothrombotic risk factors should be extensively evaluated in patients with arterial ischemic stroke.
authors.affiliation: Division of Pediatric Neurology Ege University Medical Faculty, Izmir, Turkey. stutuncu@med.ege.edu.tr
authors.forename: Sarenur
authors.initials: S
authors.lastname: Gökben
authors.forename: Ayse
authors.initials: A
authors.lastname: Tosun
authors.forename: Nuri
authors.initials: N
authors.lastname: Bayram
authors.forename: Gul
authors.initials: G
authors.lastname: Serdaroglu
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Polat
authors.forename: Kaan
authors.initials: K
authors.lastname: Kavakli
authors.forename: Hasan
authors.initials: H
authors.lastname: Tekgul
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000032:analysis / Q000097:blood; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001774:Blood Chemical Analysis; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D001798:Blood Proteins / Q000032:analysis; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D020521:Stroke / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D014421:Turkey / Q000453:epidemiology
chemical_list: D000906:Antibodies; D015415:Biomarkers; D001798:Blood Proteins