[Changes of bone density and insulin-like growth factor-1 level in elders with type 2 diabetes mellitus].
OBJECTIVE
To investigate the changes of bone mineral density(BMD) and the relationship of BMD to serum Insulin-like growth factor-1 concentrations, body mass index (BMI), waist hip ratio (WHR), estradiol (E2), testosterone (T), biochemical markers of bone turnover as well as other factors in the elderly individuals with Type 2 diabetes mellitus (T2DM).


METHODS
BMDs of spine were measured by quantitative CT for patients with T2DM (n=53) and health controls (n=40). The relationships of BMD related to serum Insulin-like growth factor-1 concentrations, BMI, WHR, E2, T, bone Gla'protein, bone alkaline phosphatase, tartrate resistant acid phosphatase 5b levels were also analyzed.


RESULTS
The spine BMD values for the T2DM patients were significantly reduced when compared with controls [(74.75 +/- 22.70) mg/cc vs. (88.04 +/- 28.29) mg/cc, P < 0.05], and the concentration of serum Insulin-like growth factor-1 in T2DM group was significantly lower than that in control [(27.63 +/- 5.74) ng/mL vs. (32.51 +/- 9.68) ng/mL, P < 0.05]. The level of serum Insulin-like growth factor-1 was positive correlation to bone-specific alkaline phosphatase (B-ALP) in the T2DM patients (r = 0.46, P < 0.01).


CONCLUSIONS
The spine BMD in elderly T2DM patients is lower than that in control group. The circulating serum Insulin-like growth factor-1 does not have a significant influence on bone mass in elderly T2DM patients.
Zeng
Shao-fan
SF
Department of Endocrinology, the Second Hospital Affiliated to Chongqing University of Medical Science, Chongqing 400010, China.
Wu
Yan
Y
Wang
Yi
Y
Yang
Gang-yi
GY
Li
Ren-ze
RZ
Zhu
Xiao-rong
XR
Tan
Xing-rong
XR
Li
Ying
Y
D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood; D049629:Waist-Hip Ratio
D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I