The use of toxicokinetic data in preclinical safety assessment: a toxicologic pathologist perspective.
Collection of toxicokinetic data has become a routine practice during the last 15 years in most general toxicity studies on pharma. It enables the correlation of pathological changes with the plasma concentration of drugs and/or their metabolites. This overview summarizes the use of the toxicokinetic data from the perspective of the toxicologic pathologist.
Ploemen
Jan-Peter H T M
JP
Department of Toxicology & Drug Disposition, Organon, The Netherlands. jan-peter.ploemen@organon.com
Kramer
Hester
H
Krajnc
Ernö I
EI
Martin
Iain
I
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010599:Pharmacokinetics; D018570:Risk Assessment; D012727:Sex Characteristics; D014116:Toxicology