title: Structure of Bombyx mori chemosensory protein 1 in solution.
abstract: Chemosensory Proteins (CSPs) represent a family of conserved proteins found in insects that may be involved in chemosensory functions. BmorCSP1 is expressed mainly in antennae and legs of the silkworm moth Bombyx mori and was cloned from antennal cDNA. Here we report the determination of the structure of Bombyx mori CSP1 (BmorCSP1) by NMR. The overall fold of BmorCSP1 is globular and comprises six alpha-helices. These helices span residues 10-14, 17-27, 35-49, 57-72, 75-85, and 92-100. The internal hydrophobic sides of the helices are formed mostly by leucine and isoleucine residues and, therefore, well suited to constitute a binding site for hydrophobic ligands.
authors.affiliation: Department of Ecology, Lund University, Lund, Sweden.
authors.forename: Séverine
authors.initials: S
authors.lastname: Jansen
authors.forename: Josef
authors.initials: J
authors.lastname: Chmelík
authors.forename: Lukás
authors.initials: L
authors.lastname: Zídek
authors.forename: Petr
authors.initials: P
authors.lastname: Padrta
authors.forename: Petr
authors.initials: P
authors.lastname: Novák
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Zdráhal
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Picimbon
authors.forename: Christer
authors.initials: C
authors.lastname: Löfstedt
authors.forename: Vladimír
authors.initials: V
authors.lastname: Sklenár
mesh_terms: D000818:Animals; D012831:Bombyx / Q000378:metabolism*; D003001:Cloning, Molecular; D019476:Insect Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary
chemical_list: C412286:CSP1 protein, Bombyx mori; D019476:Insect Proteins