The genomic structure: proof of the role of non-coding DNA.
We prove that the introns play the role of a decoy in absorbing mutations in the same way hollow uninhabited structures are used by the military to protect important installations. Our approach is based on a probability of error analysis, where errors are mutations which occur in the exon sequences. We derive the optimal exon length distribution, which minimizes the probability of error in the genome. Furthermore, to understand how can Nature generate the optimal distribution, we propose a diffusive random walk model for exon generation throughout evolution. This model results in an alpha stable exon length distribution, which is asymptotically equivalent to the optimal distribution. Experimental results show that both distributions accurately fit the real data. Given that introns also drive biological evolution by increasing the rate of unequal crossover between genes, we conclude that the role of introns is to maintain a genius balance between stability and adaptability in eukaryotic genomes.
Bouaynaya
Nidhal
N
Schonfeld
Dan
D
D000818:Animals; D001516:Bees; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D005091:Exons; D005796:Genes; D016678:Genome; D023281:Genomics; D006801:Humans; D007438:Introns; D008957:Models, Genetic; D015233:Models, Statistical; D008962:Models, Theoretical; D009154:Mutation; D011336:Probability; D051381:Rats
D004247:DNA