Hemolytic activity of aqueous extract of Livistona chinensis fruits.
Livistona chinensis is used as an anticancer agent in traditional Chinese medicine. In vitro, the extracts of fruits and seeds of L. chinensis are known to possess antiangiogenic and antiproliferative activities. Here we report the presence of phenolic compounds in L. chinensis fruits which show hemolytic activity. The hemolytic activity of phenolics is limited to an acid-precipitable fraction. Further, presence of proteins and lipids abrogated the hemolytic activity indicating astringent and membrane damaging activities as mechanisms of hemolysis. In conclusion, the hemolytic activity of phenolics in L. chinensis fruits is due to astringent and membrane damaging activities.
Singh
R P
RP
Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, Punjab, India.
Kaur
G
G
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects*; D005638:Fruit; D006461:Hemolysis / Q000187:drug effects*; D053878:Hemolytic Agents / Q000032:analysis / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D013552:Swine
D053878:Hemolytic Agents; D010636:Phenols; D010936:Plant Extracts