Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample.
Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213 cM), 2 (3.4 at 234 cM) and 10 (3.7 at 60 cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95 cM on chromosome 14. For any illicit drug dependence, LODs of 2.0 and 2.4 were observed on chromosome 10 (116 cM) and 13 (64 cM) respectively. Finally, the combined alcohol and/or drug dependence symptoms yielded LODs >2.0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence.
Agrawal
Arpana
A
Washington University School of Medicine, St Louis, MO 63110, USA. arpana@wustl.edu
Hinrichs
Anthony L
AL
Dunn
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Bertelsen
Sarah
S
Dick
Danielle M
DM
Saccone
Scott F
SF
Saccone
Nancy L
NL
Grucza
Richard A
RA
Wang
Jen C
JC
Cloninger
C Robert
CR
Edenberg
Howard J
HJ
Foroud
Tatiana
T
Hesselbrock
Victor
V
Kramer
John
J
Bucholz
Kathleen K
KK
Kuperman
Samuel
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Nurnberger
John I
JI
Porjesz
Bernice
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006801:Humans; D013287:Illicit Drugs; D002189:Marijuana Abuse / Q000175:diagnosis / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000235:genetics*; D014427:Twins / Q000235:genetics
D013287:Illicit Drugs