title: Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability.
abstract: A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surface with microscaled gibbous structures originating from ZnTCP particle agglomeration. This layer had a slow and sustained Zn release behavior. The scratch test result of the ZnTCP/FHA layer was 489+/-4mN, indicating good interface bonding between the layer and substrate. The ZnTCP/FHA layer supported cell growth, and showed a statistically significant increase in cell viability in comparison with another biphasic layer (TCP/FHA) without Zn. This work demonstrates that the present biphasic ZnTCP/FHA layer has the potential to play a significant role in enhancing bone growth when used as the outermost part of bioactive coatings on metallic implants.
authors.affiliation: Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Shundong
authors.initials: S
authors.lastname: Miao
authors.forename: Kui
authors.initials: K
authors.lastname: Cheng
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.forename: Piyi
authors.initials: P
authors.lastname: Du
authors.forename: Ge
authors.initials: G
authors.lastname: Shen
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
authors.forename: Weiqi
authors.initials: W
authors.lastname: Yan
authors.forename: Sam
authors.initials: S
authors.lastname: Zhang
mesh_terms: D002130:Calcium Phosphates; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible; D006801:Humans; D006882:Hydroxyapatites; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D013499:Surface Properties; D015032:Zinc / Q000008:administration & dosage
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate; C028869:fluor-hydroxylapatite; D015032:Zinc