A phenylpropanoid glycoside with antioxidant activity from Picria tel-ferae.
A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)- ethyl-beta-D- apiofuranosyl- (1-->4)-alpha-L-rharmnopyranosyl- (1-->3)-4-O-caffeoyl- beta-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2'-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical (Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.
Thuan
Nguyen Duy
ND
National Institute of Medicinal Materials, 3B Quangtrung, Hanoi, Vietnam.
Ha
Do Thi
do T
Thuong
Phuong Thien
PT
Na
Min Kyun
MK
Lee
Jong Pill
JP
Lee
Jeong-Hun
JH
Seo
Hyo-Won
HW
Min
Byung-Sun
BS
Kim
Jin-Cheol
JC
Bae
KiHwan
K
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D028083:Scrophulariaceae / Q000737:chemistry*
D000975:Antioxidants; D006027:Glycosides