title: Should we consider hypohidrotic ectodermal dysplasia as a possible risk factor for malignant melanoma?
abstract: BACKGROUND
  Hypohidrotic ectodermal dysplasia (HED) is a rare multisystem disorder that typically affects hair, teeth, nails, and sweat glands in combination with abnormalities of ectodermal originated tissues.
  
  
  OBJECTIVE
  To raise the issue of whether heightened awareness is required in the follow-up of pigmented lesions in patients with HED.
  
  
  RESULTS
  Two patients with HED are reported. The first had a history of two malignant melanomas, whereas the second presented with a novel malignant melanoma.
  
  
  CONCLUSIONS
  Although a prospective epidemiologic study to determine the incidence of malignant melanoma in patients with HED is virtually impossible and the probable pathogenesis warrants further investigation, these two case reports, in conjunction with other recent reports associating other ectodermal dysplasias with malignant melanoma, suggest that heightened awareness might be prudent in the follow-up of pigmented lesions in patients with HED.
authors.affiliation: Hyperhidrosis Clinic, Andreas Sygros Hospital, University of Athens, Athens, Greece. stamgreg@yahoo.gr
authors.forename: Stamatis
authors.initials: S
authors.lastname: Gregoriou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Rigopoulos
authors.forename: Theognosia
authors.initials: T
authors.lastname: Vergou
authors.forename: Chrysovalantis
authors.initials: C
authors.lastname: Korfitis
authors.forename: George
authors.initials: G
authors.lastname: Menegakis
authors.forename: George
authors.initials: G
authors.lastname: Kontochristopoulos
mesh_terms: D053358:Ectodermal Dysplasia 1, Anhidrotic / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology