title: [A clinical and pathological analysis of inclusion body myositis].
abstract: OBJECTIVE
  To study the clinical and pathological characteristics of inclusion body myositis (IBM).
  
  
  METHODS
  Comprehensive analysis of the characteristics of the clinical, laboratory and pathological of 20 patients with IBM was carried out.
  
  
  RESULTS
  Pathological features of biopsied skeletal muscle, inflammatory cells infiltrated in the perimysium, endomysium or around the blood vessels. Muscle fibers in different size, degenerating, necrotic and regenerating fibers scattered, with connective tissue elements increased. Rimmed vacuoles located in the muscles, with amyloid substance deposited around it. Ragged red fibers (RRF), abnormal distribution and types of muscle fibers. Electronmicroscopically, structure of myofibrils disordered, and Z line derangement or dismissed. In the inclusion bodies of sarcoplasma, many myelin bodies and phagocytic vacuoles aggregated, around with lipid drops and glycogen particle.
  
  
  CONCLUSIONS
  It is difficult to diagnose IBM with clinical features, while skeletal muscle biopsy and pathological analysis is a trustworthy measure for the definite diagnosis of IBM.
authors.affiliation: Department of Neuromuscular and Neuromuscular laboratory, the Third Hospital, Hebei Medical University, Shijiazhuang 050051, China. Jinghujp@Yahoo.com.cn
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Yuan
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhao
authors.forename: Hong-rui
authors.initials: HR
authors.lastname: Shen
authors.forename: Li
authors.initials: L
authors.lastname: Mei
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology* / Q000648:ultrastructure; D018979:Myositis, Inclusion Body / Q000473:pathology*