Pseudoporphyria associated with voriconazole.
Pseudoporphyria is a rare photosensitivity that resembles porphyria cutanea tarda clinically but lacks the biochemical derangements in porphyrin metabolism. The majority of cases are induced by ingestion of particular medications. We report a case of pseudoporphyria induced by voriconazole, a second-generation triazole antifungal agent, in a lung transplant recipient. Voriconazole was not discontinued due to medical necessity. The patient's pseudoporphyria was adequately controlled with UVA and UVB protection sunscreen despite continued mild sun exposure.
Kwong
Wilson T
WT
Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.
Hsu
Sylvia
S
D000935:Antifungal Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016040:Lung Transplantation; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D011164:Porphyrias / Q000175:diagnosis; D011743:Pyrimidines / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole