Effects of acute hippocampal stimulation on EEG dynamics.
Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus.
Nair
Sandeep P
SP
Dept. of Biomed. Eng., Florida Univ., Gainesville, FL 32611-6131, USA. spnair@ufl.edu
Sackellares
J Chris
JC
Shiau
Deng-Shan
DS
Norman
Wendy M
WM
Dance
Linda K
LK
Pardalos
Panos M
PM
Principe
Jose C
JC
Carney
Paul R
PR
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000628:therapy*; D004867:Equipment Design; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D051381:Rats; D012640:Seizures; D013702:Temporal Lobe / Q000473:pathology*; D013997:Time Factors
D000927:Anticonvulsants