Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea.
We report a case of Sydenham's chorea with neuropsychiatric symptoms who was successfully treated with low-dose risperidone. We also longitudinally investigated serum BDNF levels and plasma levels of catecholamine metabolite in the patient. Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease. These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease.
Umene
Wakako
W
Yoshimura
Reiji
R
Hori
Hikaru
H
Nakano
Hideki
H
Sugita
Atsuko
A
Shimono
Masayuki
M
Takano
Kenchi
K
Shiota
Naoki
N
Tomoda
Yoshinori
Y
Korogi
Yukunori
Y
Nakamura
Jun
J
D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000188:drug therapy; D001479:Basal Ganglia / Q000000981:diagnostic imaging; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002395:Catecholamines / Q000097:blood*; D002819:Chorea / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D003702:Delusions / Q000150:complications / Q000188:drug therapy; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008137:Longitudinal Studies; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D011859:Radiography; D018967:Risperidone / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D002395:Catecholamines; D008734:Methoxyhydroxyphenylglycol; D018967:Risperidone