The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium.
Berkeley Pit Lake is a 1500 ft deep abandoned open-pit copper mine filled with over 1140 billion liters of acidic, metal-sulfate-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive compounds. We recently reported the structures of berkeleydione (1) and berkeleytrione (2), two novel hybrid polyketide-terpenoid metabolites isolated from a deep water Penicillium sp. growing in Berkeley Pit Lake. In this paper we report the structures of three new compounds, berkeleyacetals A-C ( 3-5) isolated from extracts of this fungus. The structures of these compounds were deduced by comparison of mass spectral and NMR data to that of berkeleydione (1).
Stierle
Donald B
DB
Department of Chemistry, Montana Tech of University of Montana, Butte, Montana 59701, USA. dstierle@mtech.edu
Stierle
Andrea A
AA
Patacini
Brianna
B
D000143:Acids / Q000032:analysis; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification*; D014866:Waste Products / Q000032:analysis*; D014867:Water / Q000032:analysis
D000143:Acids; D018942:Macrolides; D013729:Terpenes; D014866:Waste Products; C525482:berkeleyacetal A; C525483:berkeleyacetal B; C525484:berkeleyacetal C; C493366:berkeleydione; D014867:Water