title: [Non invasive markers using for the assessment of fibrosis in hepatitis C].
abstract: Non invasive fibrosis markers, recently developed, are now an interesting alternative to liver biopsy in order to appreciate the severity of chronic hepatitis C. Serological markers, especially Fibrotest and Fibrometer, have a good diagnostic accuracy to discriminate patients with mild fibrosis to those with severe fibrosis. For intermediate stages, the discordance is very important and often justifies liver biopsy or using of several markers. Transient elastography (Fibroscan) is a new non invasive method subject to good conditions of utilisation. Diagnostic accuracy is improved by the using of all the markers, especially of Fibrotest. Transient elastography is also a promising method for assessing the severity of cirrhosis.
authors.affiliation: Clinique Universitaire d'Hépato-Gastroentérologie, Pôle DIGI-DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble cedex 9. jpzarski@chu-grenoble.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Zarski
authors.forename: Pierre
authors.initials: P
authors.lastname: Bedossa
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bronowicki
authors.forename: Michel
authors.initials: M
authors.lastname: Doffoel
authors.forename: Thierry
authors.initials: T
authors.lastname: Poynard
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D054459:Elasticity Imaging Techniques; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000821:virology; D008111:Liver Function Tests; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers