Drug removal by plasmapheresis: an evidence-based review.
Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications-mostly case reports of overdoses-have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.
Ibrahim
Rami B
RB
Department of Pharmacy, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201-2013, USA. ibrahim@Karmanos.org
Liu
Chin
C
Cronin
Simon M
SM
Murphy
Bridgette C
BC
Cha
Raymond
R
Swerdlow
Paul
P
Edwards
David J
DJ
D062787:Drug Overdose / Q000628:therapy; D019317:Evidence-Based Medicine; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D010951:Plasma Exchange / Q000379:methods*; D010956:Plasmapheresis / Q000379:methods*; D011041:Poisoning / Q000628:therapy*
D004364:Pharmaceutical Preparations