Postoperative hyperbilirubinemia and graft outcome in living donor liver transplantation.
Little information is available on the characteristics and clinical significance of serum bilirubin level early after liver transplantation. The aim of this study was to clarify the risk factors for early graft loss and to assess the significance of postoperative hyperbilirubinemia as a predictor of graft outcome in living donor liver transplantation (LDLT). We retrospectively analyzed perioperative parameters in 68 patients who underwent LDLT. Graft loss within 1 year post-LDLT was confirmed in 9 patients (13.4%). Univariate analysis of risk factors showed that preoperative Model for End-Stage Liver Disease score, donor age, postoperative peak serum bilirubin level (p-BIL) within 28 days after LDLT, and surgical complications were significant determinants of early graft loss (<1 year post-transplant). Multivariate analysis identified p-BIL (odds ratio = 1.170, 95% confidence interval = 1.030-1.329, P = 0.016) as the only independent predictor of early graft loss. The incidence of such loss was high in patients with p-BIL over 27.0 mg/dL (area under the receiver operating characteristic curve = 0.988). In conclusion, serum bilirubin level is a useful predictor of short-term (<1 year) graft outcome and for considering retransplantation in a timely fashion.
Marubashi
Shigeru
S
Department of Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan.
Dono
Keizo
K
Nagano
Hiroaki
H
Asaoka
Tadafumi
T
Hama
Naoki
N
Kobayashi
Shogo
S
Miyamoto
Atsushi
A
Takeda
Yutaka
Y
Umeshita
Koji
K
Monden
Morito
M
D019540:Area Under Curve; D005260:Female; D006084:Graft Rejection / Q000652:urine*; D006085:Graft Survival; D006801:Humans; D006932:Hyperbilirubinemia; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors