Effects of microinjections of glutamate and glutamate receptor antagonists into A5 zone on generation of respiratory rhythm in ponto-bulbospinal preparations from newborn rats in vitro.
Activation of glutamate receptors in A5 neurons enhanced their tonic inhibitory influence on the respiratory rhythm generator in isolated newborn rat ponto-bulbospinal preparations. The stimulating effect of glutamate on A5 neurons is determined by its effect mainly on non-NMDA receptors and less so on NMDA receptors.
Alekseyeva
A S
AS
Department of Normal Physiology, Samara State Medical University, Russian Ministry of Health. alexandrasa@rambler.ru
Pyatin
V F
VF
Yakunina
O V
OV
D000818:Animals; D000831:Animals, Newborn; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D018698:Glutamic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D008845:Microinjections; D008953:Models, Anatomic; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011149:Pons / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid