title: Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats.
abstract: Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fiber-rich food, on the induction of acute colitis by dextran sulfate sodium (DSS) were examined. Feeding a 5% and 10% FBRA-containing diet significantly decreased the ulcer and erosion area in the rat colon stained with Alcian blue. In another experiment, 10% FBRA feeding decreased the ulcer index (percentage of the total length of ulcers in the full length of the colon) and colitis score, which were determined by macroscopic observation. It also decreased myeloperoxidase activity in the colonic mucosa. Viable cell numbers of Lactobacillus in the feces decreased after DSS administration and was reversely correlated with severity of colitis, while the cell number of Enterobacteriaceae increased after DSS treatment and was positively correlated with colitis severity. These results indicate that FBRA has a suppressive effect on the induction of colitis by DSS and suggest FBRA-mediated modification of colonic microbiota.
authors.affiliation: Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. kataoka@basic.med.tokushima-u.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Kataoka
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ogasa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Bando
authors.forename: Mari
authors.initials: M
authors.lastname: Hagiwara
authors.forename: Hideki
authors.initials: H
authors.lastname: Arimochi
authors.forename: Shuusuke
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Teruaki
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Ohnishi
mesh_terms: D000208:Acute Disease; D000818:Animals; D001236:Aspergillus oryzae; D016009:Chi-Square Distribution; D003092:Colitis / Q000178:diet therapy*; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D016264:Dextran Sulfate; D005285:Fermentation; D009747:Nutritional Physiological Phenomena; D012275:Oryza / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D016264:Dextran Sulfate; D009195:Peroxidase