Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma.
Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.
Naqvi
Mariam
M
University of California, San Francisco, California 94110, USA.
Thyne
Shannon
S
Choudhry
Shweta
S
Tsai
Hui-ju
HJ
Navarro
Daniel
D
Castro
Richard A
RA
Nazario
Sylvette
S
Rodriguez-Santana
Jose R
JR
Casal
Jesus
J
Torres
Alfonso
A
Chapela
Rocio
R
Watson
H Geoffrey
HG
Meade
Kelley
K
LeNoir
Michael
M
Avila
Pedro C
PC
Rodriguez-Cintron
William
W
Burchard
Esteban González
EG
D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000208:ethnology* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008800:Mexico; D009519:New York City; D011647:Puerto Rico; D012495:San Francisco; D018709:Statistics, Nonparametric; D014797:Vital Capacity / Q000187:drug effects
D001993:Bronchodilator Agents; D000420:Albuterol