Serum levels of the adipokine vaspin in relation to metabolic and renal parameters.
BACKGROUND
Recently, vaspin was identified as an insulin-sensitizing adipokine. However, regulation of this adipocyte-secreted factor in human disease has not been determined.


OBJECTIVE
We investigated vaspin serum concentrations in diabetic and nondiabetic patients on chronic hemodialysis (CD) as compared with controls with a glomerular filtration rate (GFR) above 50 ml/min.


METHODS
Vaspin was quantified by ELISA in control (n = 60) and CD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups.


RESULTS
Mean serum vaspin concentrations were not significantly different between CD patients and controls. Circulating vaspin was significantly lower in males (0.6 +/- 0.9 microg/liter) as compared with females (1.3 +/- 1.5 microg/liter) and was decreased in insulin-treated subjects. In univariate analyses, vaspin levels positively correlated with age and high-density lipoprotein cholesterol and negatively with waist-to-hip ratio and GFR in control patients, whereas the adipokine was negatively associated with GFR and C-reactive protein (CRP) in CD patients. In multivariate analyses, age and gender were independently associated with vaspin in controls, whereas gender, GFR, and CRP independently predicted circulating vaspin in CD patients.


CONCLUSIONS
Vaspin levels are significantly higher in women, and gender is an independent predictor of circulating vaspin in both control and CD patients. In addition, age independently predicts vaspin in control patients, whereas GFR and CRP are independently associated with this adipokine in CD patients. In contrast, circulating vaspin is not independently associated with markers of glucose and lipid metabolism.
Seeger
Jeannette
J
Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany.
Ziegelmeier
Michaela
M
Bachmann
Anette
A
Lössner
Ulrike
U
Kratzsch
Jürgen
J
Blüher
Matthias
M
Stumvoll
Michael
M
Fasshauer
Mathias
M
D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015843:Serpins / Q000097:blood*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; C507339:SERPINA12 protein, human; D015843:Serpins; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D003404:Creatinine