title: Effects of vehicles and enhancers on transdermal delivery of clebopride.
abstract: The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 microg/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Rhee
authors.forename: Jai-Yong
authors.initials: JY
authors.lastname: Huh
authors.forename: Chun-Woong
authors.initials: CW
authors.lastname: Park
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Nam
authors.forename: Koog-Ryul
authors.initials: KR
authors.lastname: Yoon
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Chi
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D010539:Permeability; D014677:Pharmaceutical Vehicles; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D012995:Solubility
chemical_list: D001549:Benzamides; D014677:Pharmaceutical Vehicles; C014417:clebopride