title: [Unresectable gallbladder cancer with lymph node and liver metastases completely responding to S-1 monotherapy - a case report].
abstract: We report a patient with gallbladder cancer and multiple liver and lymph node metastases which completely responded to S-1, an oral fluoropyrimidine anticancer drug. The patient was enrolled in the "Late phase II study of S-1 in patients with advanced biliary tract cancer". A partial response was confirmed after the first two courses of S-1 monotherapy, and anti-tumor efficacy was finally evaluated as a complete response after the 5th course. S-1 was discontinued after the 18th course because of long CR, and the patient has been alive and disease-free for more than 3 years. Grade 2 anorexia, diarrhea, hand-foot skin reaction, and tasty disturbance were observed, but no grade 3 or more toxicities were noted. S-1 appeared to be effective against advanced gallbladder cancer and showed excellent tolerability.
authors.affiliation: Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East.
authors.forename: Junji
authors.initials: J
authors.lastname: Furuse
authors.forename: Kohei
authors.initials: K
authors.lastname: Nakachi
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Suzuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshino
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use / Q000633:toxicity; D004338:Drug Combinations; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid