[Case of fatal liver failure due to anti-tuberculous therapy].
A 65-year-old female was started anti-tuberculous therapy for her pulmonary tuberculosis on admission. Liver dysfunction had occurred on 33rd day after starting treatment. AST was elevated to 301 IU/L, and ALT was also elevated to 141 IU/L. Therefore, all medicated drugs were stopped. She had jaundice on 42nd day and liver failure deteriorated. She was medicated with steroids, but she died by liver failure on 64th day. This is a rare case of fatal liver failure due to antituberculous therapy.
Harada
Yoshitaka
Y
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center of Neurology, 2005-1, Shimogumigou, Kawatana-cho, Higashisonogi-gun, Nagasaki 859-3615, Japan.
Kawakami
Kenji
K
Koyama
Kazuhiko
K
Yamaryo
Takeshi
T
Kimura
Yumiko
Y
D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D017093:Liver Failure / Q000139:chemically induced*; D011718:Pyrazinamide / Q000009:adverse effects*; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin