title: Preterm premature rupture of membranes in pregnancies complicated by human immunodeficiency virus infection: a single center's five-year experience.
abstract: OBJECTIVE
  The objective of this study was to describe one center's five-year experience of the management of human immunodeficiency virus (HIV) positive gravidas with preterm premature rupture of the membranes (PPROM) not in labor at <or=34 weeks of gestation.
  
  
  METHODS
  This is a retrospective chart review of all HIV positive gravidas with PPROM at <or=34 weeks of gestation, who delivered between December 1, 2000 and December 31, 2005.
  
  
  RESULTS
  We identified 228 HIV positive gravidas of whom 19 had PPROM at <or=34 weeks of gestation. Mother-to-child transmission occurred in two of 18 surviving neonates as confirmed by a follow-up visit at six months of age. No mother-to-child transmission occurred in the 10 neonates of mothers who received antenatal highly active antiretroviral therapy and intrapartum zidovudine. Eleven neonates were delivered between 30 and 33 weeks of gestation. In this group, five of 11 gravidas received antenatal corticosteroids. The mean neonatal hospital stay was 31 days with or without prophylactic treatment of the mothers with antenatal corticosteroids.
  
  
  CONCLUSIONS
  In this study of HIV positive patients with PPROM, the mother-to-child transmission rate of HIV did not seem to be related to the duration of rupture of membranes prior to delivery.
authors.affiliation: UMDNJ-New Jersey Medical School, Department of Obstetrics, Gynecology and Women's Health, Newark, New Jersey 07103, USA.
authors.forename: Jesus R
authors.initials: JR
authors.lastname: Alvarez
authors.forename: Arlene
authors.initials: A
authors.lastname: Bardeguez
authors.forename: Leslie
authors.initials: L
authors.lastname: Iffy
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Apuzzio
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002585:Cesarean Section; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D047928:Premature Birth; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones