Gingival enlargement in Niemann-Pick disease: a coincidence or link? Report of a unique case.
A case of a 25-year-old man appearing with generalized gingival enlargement is reported here. Niemann-Pick disease (NPD) was provisionally diagnosed by histopathologic analysis of tissue excised by gingivectomy and later confirmed by quantitative enzyme assay. Correlation between clinical features and histopathologic and biochemical analysis enabled the diagnosis of NPD type C.
Kaisare
Sumeet
S
Department of Oral and Maxillofacial Surgery, Goa Dental College and Hospital, Bambolim, Goa, India. sumeetkaisare@rediffmail.com
D000015:Abnormalities, Multiple; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D019214:Gingival Overgrowth / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005890:Gingivectomy; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging; D008439:Maxillary Diseases / Q000000981:diagnostic imaging; D052556:Niemann-Pick Disease, Type C / Q000150:complications*; D011859:Radiography; D012008:Recurrence; D015203:Reproducibility of Results; D013108:Sphingomyelin Phosphodiesterase / Q000032:analysis
C112980:acid sphingomyelinase-1; D013108:Sphingomyelin Phosphodiesterase