title: CORUM: the comprehensive resource of mammalian protein complexes.
abstract: Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.
authors.affiliation: Institute for Bioinformatics (MIPS), German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany. andreas.ruepp@gsf.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Ruepp
authors.forename: Barbara
authors.initials: B
authors.lastname: Brauner
authors.forename: Irmtraud
authors.initials: I
authors.lastname: Dunger-Kaltenbach
authors.forename: Goar
authors.initials: G
authors.lastname: Frishman
authors.forename: Corinna
authors.initials: C
authors.lastname: Montrone
authors.forename: Michael
authors.initials: M
authors.lastname: Stransky
authors.forename: Brigitte
authors.initials: B
authors.lastname: Waegele
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schmidt
authors.forename: Octave Noubibou
authors.initials: ON
authors.lastname: Doudieu
authors.forename: Volker
authors.initials: V
authors.lastname: Stümpflen
authors.forename: H Werner
authors.initials: HW
authors.lastname: Mewes
mesh_terms: D000818:Animals; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D051379:Mice; D046912:Multiprotein Complexes / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes