Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.
C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases of acute AMR served as controls. C4d deposition in PTC was found in 31 patients (6.81%) with LN. Patients with PTC C4d positive showed higher SLEDAI score and higher frequency of hypocomplementemia as compared to C4d negative. The prevalence of ANA, anti-dsDNA, anti-Sm and ACA were higher in C4d positive group, and most of these patients showed the diffuse proliferative glomerular lesion. In contrast with acute AMR, the staining pattern of C4d was granular deposition and the detection of C4d along PTC was accompanied by deposition of IgG and C1q or C3. Electron dense deposition on PTC was observed in most of LN patients. In conclusion, C4d deposition in PTC could be found in a small part of patients with LN. Our study suggested for the first time that C4d positive deposition were close relation with the higher disease activity of LN, and that immune complex formation might be involved in PTC C4d deposition in LN patients, Such PTC C4d deposition is distinct from that of AMR.
Li
S-J
SJ
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, People's Republic of China.
Liu
Z-H
ZH
Zen
C-H
CH
Wang
Q-W
QW
Wang
Y
Y
Li
L-S
LS
D000293:Adolescent; D000328:Adult; D002196:Capillaries / Q000276:immunology / Q000503:physiopathology*; D016022:Case-Control Studies; D003181:Complement C4 / Q000276:immunology* / Q000378:metabolism; D015935:Complement C4b / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D007684:Kidney Tubules / Q000098:blood supply*; D008181:Lupus Nephritis / Q000503:physiopathology*; D008297:Male; D010446:Peptide Fragments / Q000276:immunology*
D003181:Complement C4; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d