Development of strategies for the regiocontrolled synthesis of meso-5,10,20-triaryl-2,3-chlorins.
Triglycoconjugated photosensitizers show promise for use in the photodynamic therapy-based treatment of cancer. Two different routes have been studied for the regioselective preparation of 5,10,20-meso-triphenyl-2,3-chlorin, 9a, and 5,10,20-meso-tri(4-isopropyloxyphenyl)-2,3-chlorin, 9b. The main issue was to control the placement of the partially reduced pyrrole ring in the more hindered environment in the triarylchlorin products.
Varamo
Marilyne
M
UMR 176 CNRS/Institut Curie, Institut Curie, Bât. 110, Centre Universitaire, Université Paris-Sud XI, Orsay, France.
Loock
Bernard
B
Maillard
Philippe
P
Grierson
David S
DS
D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000737:chemistry; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
D005960:Glucosides; D011166:Porphyrins; C006969:chlorin