title: Development of software facilities to characterize regulatory binding motifs and application to streptococcaceae.
abstract: Gene expression regulation often involves the recognition of particular DNA or RNA sequences, called motifs. Detection and characterization of such motifs together with biological expertise allow to build gene expression regulatory maps that facilitate the comprehension of complex cellular processes. In this frame, we developed a software integrating relevant information for the detection and characterization of conserved motifs in genomic sequences. A relational database was built up to host data related to genomic information and transcriptional experiments. A user-friendly interface was designed to allow a convenient representation of these data and to run the detection motif program. A set of complementary utilities was also developed to improve the determination of motif consensus sequences and the detection of additional potential regulator targets in the genome.
authors.affiliation: Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pons
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Batto
authors.forename: Stanislav Dusko
authors.initials: SD
authors.lastname: Ehrlich
authors.forename: Pierre
authors.initials: P
authors.lastname: Renault
mesh_terms: D020816:Amino Acid Motifs; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D030561:Databases, Nucleic Acid; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D023281:Genomics; D017045:Lactococcus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D012984:Software; D013289:Streptococcaceae / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013291:Streptococcus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014584:User-Computer Interface