title: Multicomponent reactions in fungicide research: the discovery of mandipropamid.
abstract: Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew).
authors.affiliation: Syngenta Crop Protection AG, Research Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland. clemens.lamberth@syngenta.com
authors.forename: Clemens
authors.initials: C
authors.lastname: Lamberth
authors.forename: Andre
authors.initials: A
authors.lastname: Jeanguenat
authors.forename: Fredrik
authors.initials: F
authors.lastname: Cederbaum
authors.forename: Alain
authors.initials: A
authors.lastname: De Mesmaeker
authors.forename: Martin
authors.initials: M
authors.lastname: Zeller
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Kempf
authors.forename: Ronald
authors.initials: R
authors.lastname: Zeun
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001550:Benzamidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010838:Phytophthora / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014633:Valine / Q000737:chemistry
chemical_list: D000577:Amides; D001550:Benzamidines; D002264:Carboxylic Acids; D005659:Fungicides, Industrial; C550943:mandipropamid; C005555:propamidine; D014633:Valine