title: Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections.
abstract: Gentamicin is an aminoglycoside with a wide spectrum of antibacterial activity. However, as a highly water-soluble drug, it penetrates cells poorly. This constitutes a particularly important drawback for treating intracellular bacterial infections. This major hurdle may be solved by the use of vectors to deliver and target bioactive agents to the intracellular sites of infection. Thus, in the case of antimicrobials, drug delivery systems may help to increase their therapeutic index in intracellular locations. The development and evolution of pharmaceutical forms of gentamicin for the parenteral treatment of intracellular pathogens is reviewed in this paper.
authors.affiliation: University of Navarra, Department of Microbiology, 31080 Pamplona, Spain. cgamazo@unav.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Gamazo
authors.forename: Sandra
authors.initials: S
authors.lastname: Prior
authors.forename: María
authors.initials: M
authors.lastname: Concepción Lecároz
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Vitas
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Campanero
authors.forename: Guiomar
authors.initials: G
authors.lastname: Pérez
authors.forename: David
authors.initials: D
authors.lastname: Gonzalez
authors.forename: María Jose
authors.initials: MJ
authors.lastname: Blanco-Prieto
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008081:Liposomes; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D005839:Gentamicins; D008081:Liposomes