Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis.
Alcoholic chronic pancreatitis (ACP) develops in only a small number of alcoholics. Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. However, their role in pathogenesis of ACP has not been investigated. A genetic association study for susceptibility and severity was performed on 79 male Korean ACP patients and 82 male controls. MCP-1 and HSP70-2 genotypes were determined using a fluorescence polarization detection method. The genotypes and G allele frequencies were no different in patients and controls. However, MCP-1 G allele had an effect on the development of severe ACP, when its frequency was compared in mild to moderate and severe ACP (29.6 vs. 56.0%, P = 0.02). The MCP-1 and HSP70-2 polymorphisms do not play a major role in the development of ACP in Koreans. However, MCP-1 polymorphism may be associated with the severity of ACP.
Lee
Sang Hyub
SH
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Yeongeon-dong 28, Jongno-gu, Seoul 110-744, Korea.
Ryu
Ji Kon
JK
Jeong
Ji Bong
JB
Lee
Kyeung-Yeup
KY
Woo
Sang Myung
SM
Park
Joo Kyung
JK
Yoo
Ji Won
JW
Kim
Yong-Tae
YT
Yoon
Yong Bum
YB
D018932:Chemokine CCL2 / Q000235:genetics*; D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000453:epidemiology / Q000235:genetics*; D050500:Pancreatitis, Chronic / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D011446:Prospective Studies
D018932:Chemokine CCL2; D018840:HSP70 Heat-Shock Proteins