Integrins: a flexible platform for endothelial vascular tyrosine kinase receptors.
Compared to lower metazoans, vertebrates built up an exclusively new set of adhesion-related genes involved in the tissue development and in their functions. They include a large variety of extracellular matrix proteins and their heterodimeric integrin adhesive receptors. Integrins control the adhesive state of the cell through complex molecular mechanisms. Outside-in signalling informs the cell about the extracellular matrix environment, while Inside-out signalling results in changes in integrin functional activity. In the last 10 years it has well established a reciprocal integration of signals originating from integrins and receptors for soluble growth factors. This review summarizes the current understanding of this connection in vascular endothelial cells and highlights how integrins regulate a genetic program triggered by angiogenic inducers during embryo development and in adult life.
Napione
Lucia
L
Dipartimento di Scienze Oncologiche, Università di Torino, 10060 Candiolo, Italy; Istituto per la Ricerca e la Cura del Cancro, Università di Torino, 10060 Candiolo, Italy.
Cascone
Ilaria
I
Dipartimento di Scienze Oncologiche, Università di Torino, 10060 Candiolo, Italy; Istituto per la Ricerca e la Cura del Cancro, Università di Torino, 10060 Candiolo, Italy.
Mitola
Stefania
S
Dipartimento di Scienze Biomediche e Biotecnologie, Università di Brescia, 25100 Brescia, Italy.
Serini
Guido
G
Dipartimento di Scienze Oncologiche, Università di Torino, 10060 Candiolo, Italy; Istituto per la Ricerca e la Cura del Cancro, Università di Torino, 10060 Candiolo, Italy.
Bussolino
Federico
F
Dipartimento di Scienze Oncologiche, Università di Torino, 10060 Candiolo, Italy; Istituto per la Ricerca e la Cura del Cancro, Università di Torino, 10060 Candiolo, Italy. Electronic address: federico.bussolino@unito.it.
D042682:Angiopoietins / Q000378:metabolism; D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D039081:Integrin alpha5beta1 / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D042787:Receptor, TIE-2 / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042682:Angiopoietins; D015815:Cell Adhesion Molecules; D016207:Cytokines; D016228:Endothelial Growth Factors; D039081:Integrin alpha5beta1; D016023:Integrins; D042461:Vascular Endothelial Growth Factor A; D020794:Receptor Protein-Tyrosine Kinases; D042787:Receptor, TIE-2; D040262:Receptors, Vascular Endothelial Growth Factor