title: Heparin-induced thrombocytopenia associated with interleukin-8-dependent platelet activation in a patient with antiphospholipid syndrome.
abstract: Platelet factor 4 heparin enzyme immunoassay, platelet aggregation test, and serotonin release assay are commonly used to diagnose and confirm heparin-induced thrombocytopenia. We describe a case of recurrent thrombocytopenia appearing in a few hours after each heparin administration and who tested negative for the three assays. Further analysis revealed anti-interleukin (IL)-8 antibodies and IL-8-dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin-induced thrombocytopenia.
authors.affiliation: Medical Department, Community Hospital of La Chaux-de-Fonds, La Chaux-de-Fonds, Switzerland. claire.bounameaux@ne.ch
authors.forename: Claire
authors.initials: C
authors.lastname: Bounameaux
authors.forename: Françoise
authors.initials: F
authors.lastname: Boehlen
authors.forename: Aurélie
authors.initials: A
authors.lastname: Membré
authors.forename: Daniel
authors.initials: D
authors.lastname: Genné
authors.forename: Claire
authors.initials: C
authors.lastname: Pouplard
authors.forename: Véronique
authors.initials: V
authors.lastname: Regnault
authors.forename: Philippe
authors.initials: P
authors.lastname: de Moerloose
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D016209:Interleukin-8 / Q000097:blood*; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood* / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D016209:Interleukin-8; D006493:Heparin