Trichostrongylus colubriformis and Haemonchus contortus infections in light bodyweight Merino lambs.
OBJECTIVE; To show that low bodyweight is a predisposing cause of high Trichostrongylus colubriformis and Haemonchus contortus burdens and egg counts in Merino lambs.


METHODS
A comparison was made, among lambs of different bodyweights, on the effect on immunity of a primary or secondary viable infection with T colubriformis or H contortus larvae.


METHODS
Sixty-one Merino lambs, 1 or 6 months of age, were penned indoors and given primary, or both primary and secondary, infection of T colubriformis or H contortus. Faecal egg counts, worm counts and parasite-specific immunoglobulin concentrations were examined for their relationships with bodyweight.


RESULTS
Bodyweight at the start of a primary infection was correlated with worm burden, worm fecundity and jejunal IgA antibody concentration. Merino lambs weighing less than 23 kg at the time of first exposure to T colubriformis or H contortus had impaired ability to develop protective mucosal immunity and to resist homologous challenge.


CONCLUSIONS
If the goal is to ensure that lambs develop immunity before weaning, then every endeavour should be made to achieve the combination of critical bodyweight and exposure to moderate levels of nematode infection as soon as possible.
McClure
S J
SJ
FD McMaster Laboratory, CSIRO Livestock Industries, Locked Bag 1, Delivery Centre, Armidale NSW 2350, Australia. susan.mcclure@csiro.au
Emery
D L
DL
D000818:Animals; D000831:Animals, Newborn; D000909:Antibodies, Helminth / Q000032:analysis; D001835:Body Weight / Q000502:physiology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D006189:Haemonchus / Q000302:isolation & purification; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000032:analysis; D007583:Jejunum / Q000276:immunology; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D012720:Severity of Illness Index; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D014253:Trichostrongylosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D014254:Trichostrongylus / Q000302:isolation & purification
D000909:Antibodies, Helminth; D007070:Immunoglobulin A