title: Co-administration of Dalbergia odorifera increased bioavailability of Salvia miltiorrhizae in rabbits.
abstract: This study was to investigate the effect of Dalbergia odorifera (DO) on the pharmacokinetics of Danshensu in Salvia miltiorrhiza (SM) in healthy rabbits and rabbits with qi-stagnancy and blood stasis. Thirty two healthy rabbits were involved in the whole experiment. Qi-stagnancy and blood stasis rabbits were obtained by treating the limbs of 16 adnephrin rabbits in an ice-bath for 6.0 min. The rest of rabbits were equally divided into 2 healthy groups. One healthy group and 8 qi-stagnancy and blood stasis rabbits were orally administrated with SM (5.0 g/kg), and the other 8 healthy rabbits and 8 qi-stagnancy and blood stasis rabbits with SM (5.0 g/kg) coupled with DO (2.5 g/kg). The plasma (Danshensu) concentration-time curve was measured by high performance liquid chromatography (HPLC)-electrospray ionization (ESI)-trap mass (MS-MS). Danshensu in plasma was confirmed to be two-compartment open model with a first order absorption phase in all groups. Moreover, the area under curve (0-infinity) of Danshensu was significantly increased both in healthy group and in qi-stagnancy and blood stasis group after administration of SM coupled with DO. This result was in accordance with the "Jun-Shi pairing herbs theory" of traditional Chinese medicine (TCM).
authors.affiliation: Institute of Analytical Science/Shaanxi Provincial Key Laboratory of Elecetroanalytical Chemistry, Northwest University, Northwest University, Xi'an 710069, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Zhao
authors.forename: Shixiang
authors.initials: S
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Luo
authors.forename: Yinmao
authors.initials: Y
authors.lastname: Wei
authors.forename: Jianbin
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D035782:Dalbergia / Q000737:chemistry*; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits; D027544:Salvia / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D010936:Plant Extracts