title: Chromatin challenges during DNA replication: a systems representation.
abstract: In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.
authors.affiliation: Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. kohnk@dc37a.nci.nih.gov
authors.forename: Kurt W
authors.initials: KW
authors.lastname: Kohn
authors.forename: Mirit I
authors.initials: MI
authors.lastname: Aladjem
authors.forename: John N
authors.initials: JN
authors.lastname: Weinstein
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D019175:DNA Methylation; D004261:DNA Replication; D042522:DNA Replication Timing; D006657:Histones / Q000378:metabolism; D009707:Nucleosomes / Q000378:metabolism
chemical_list: D002843:Chromatin; D006657:Histones; D009707:Nucleosomes