[The state of keratinocytes of interfollicular epidermis after 13-cis-retinoic acid application (immunocytochemical analysis)].
Immunocytochemical methods were used to study the population of keratinocytes of interfollicular epidermis in rats under the conditions of morphogenesis, experimentally modified by an application of 13-cis-retinoic acid (0.025% and 0.05% solutions for two weeks). The treatment resulted in the increase of the number of PCNA+ and Ki-67+ nuclei in the epidermis and of the thickness of epithelial cell layer, not involved in cytokeratin 10 synthesis.
Zhuchkov
S A
SA
D000818:Animals; D004817:Epidermis / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development; D007150:Immunohistochemistry; D015474:Isotretinoin / Q000494:pharmacology*; D015603:Keratinocytes / Q000737:chemistry / Q000187:drug effects*; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D009024:Morphogenesis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar
D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D015474:Isotretinoin