title: Liver function tests in children with blunt abdominal traumas.
abstract: BACKGROUND
  Previous studies have suggested that there are cut-off values for liver function tests (LFTs) beneath which significant liver injury can be excluded after blunt abdominal trauma in children. Our objective is to test this hypothesis in our patient population.
  
  
  METHODS
  The LFTs of all consecutive patients admitted in Geneva from January 1, 2001 to December 31, 2004 following blunt abdominal trauma were analysed and compared to radiological (ultrasound and/or computed tomography scan) findings and final outcome.
  
  
  RESULTS
  Of 115 patients identified, sixteen had radiological evidence of liver injury. These patients had significantly (p < 0.01) increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values (474 +/- 369 IU/l and 442 +/- 383 IU/l, respectively) compared to patients without liver injury (AST 88 +/- 161 IU/l and ALT 68 +/- 137 IU/l). Among the sixteen patients with liver injury, ten (63 %) had AST < 450 IU/l and seven (44 %) had ALT < 250 IU/l. Two patients had radiological evidence of OIS grade 3 liver injury with AST as low as 95 and 92, and ALT of 80 and 86, below all cut-off values recommended in the literature.
  
  
  CONCLUSIONS
  In our experience, low LFT values at admission could not rule out significant liver injury. The diagnosis of such lesions still relies on clinical and radiological findings, as do other intra-abdominal organ injuries.
authors.affiliation: Paediatric Surgery Clinic, University of Geneva Children's Hospital, Geneva, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Karam
authors.forename: G
authors.initials: G
authors.lastname: La Scala
authors.forename: C
authors.initials: C
authors.lastname: Le Coultre
authors.forename: C
authors.initials: C
authors.lastname: Chardot
mesh_terms: D000007:Abdominal Injuries / Q000097:blood / Q000175:diagnosis*; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000293:injuries*; D008111:Liver Function Tests; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D015599:Trauma Severity Indices; D018608:Ultrasonography, Doppler; D014949:Wounds, Nonpenetrating / Q000097:blood / Q000175:diagnosis*
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase