An erythrodermic variant of pemphigus foliaceus with puzzling histologic and immunopathologic features.
BACKGROUND
Pemphigus foliaceus is an autoimmune blistering disorder that affects the skin owing to autoantibodies against desmoglein 1.


METHODS
We employed clinical, histologic, immunopathologic, and serum laboratory studies to investigate a case of an erythrodermic variant of pemphigus foliaceus in an elderly man following treatment with bisoprolol-hydrochlorothiazide.


RESULTS
Early histopathology revealed psoriasiform dermatitis, but later biopsies showed subcorneal and granular layer separation with neutrophilic infiltrate. Direct immunofluorescence showed intercellular deposits of immunoglobulin G throughout the epidermis, granular staining of C3 along the basement membrane zone, and fibrin and C3 deposition around the blood vessels. Indirect immunofluorescence on monkey esophagus showed a titer of greater than 1:1,280. Indirect immunofluorescence on rat bladder, antinuclear antibody, lupus panel, and kidney function panel were all negative.


CONCLUSIONS
There are no reports in the literature of pemphigus foliaceus being induced by bisoprolol, but reports exist of propanolol resulting in drug-induced pemphigus foliaceus.
Peterson
Jennifer D
JD
Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
Worobec
Sophie M
SM
Chan
Lawrence S
LS
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003873:Dermatitis, Exfoliative / Q000209:etiology; D051183:Desmoglein 1 / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007159:Immunologic Tests; D008297:Male; D009504:Neutrophils; D010392:Pemphigus / Q000145:classification / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies; D003176:Complement C3; D051183:Desmoglein 1; D007074:Immunoglobulin G