title: Continuous cardiac output and left atrial pressure monitoring by pulmonary artery pressure waveform analysis.
abstract: We introduce a novel technique for continuous (i.e., automatic) monitoring of cardiac output (CO) and left atrial pressure (LAP) by mathematical analysis of a pulmonary artery pressure (PAP) waveform. To obtain an initial evaluation of the technique, we applied it to PAP waveforms obtained from nine critically ill patients and compared the resulting CO and LAP estimates with standard operator-dependent thermodilution and pulmonary capillary wedge pressure measurements, respectively. We report that the technique achieved an overall CO error of 17.2% and an overall LAP error of 15.8%. With further testing, the technique may ultimately be employed so as to permit, for the first time, continuous CO and LAP monitoring in critically ill patients.
authors.affiliation: Dept. of Electrical & Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. luzhenwe@msu.edu
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Lu
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Mukkamala
mesh_terms: D016275:Atrial Function / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods*; D002302:Cardiac Output / Q000502:physiology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D008991:Monitoring, Physiologic / Q000379:methods; D011651:Pulmonary Artery / Q000502:physiology*; D011673:Pulsatile Flow / Q000502:physiology