title: Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.
abstract: A meta-regression analysis was undertaken to evaluate the association between delta-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61 microg/dl. Using a random effects model, the pooled estimate was also significant at 1.51 microg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shen
authors.forename: Zhong-Xu
authors.initials: ZX
authors.lastname: Wang
authors.forename: Qing-Yi
authors.initials: QY
authors.lastname: Wei
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000328:Adult; D002648:Child; D004781:Environmental Exposure; D006801:Humans; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000235:genetics; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000623:Porphobilinogen Synthase / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D007854:Lead; D000623:Porphobilinogen Synthase