High pretransplantation soluble CD30 levels: impact in renal transplantation.
In a retrospective study, the impact of the level of pretransplantation soluble CD30 molecule (sCD30) was evaluated on 3 year transplant survival, as well as the number and grade of acute rejection episodes among kidney recipients engrafted between 2000 and 2002. One hundred and ninety sera of 190 patients sampled on the cross-match day were tested for sCD30 concentrations using an enzyme-linked immunosorbent assay (ELISA) kit (Biotest). For the analysis, a sCD30 cutoff level of 100 U/mL was chosen: 87 (46%) recipients had a level >100, and 103 (54%) <100. All cases (5) of immunological graft loss showed a high sCD30 level. The rate of biopsy-proven acute rejection was 26% in the sCD30 >100 group versus 22% in the sCD30 <100 groups. Among the first graft population (n = 157), the rate was 27% for sCD30 >100 versus 20% for the lower level. The difference was more important for grade II acute rejection (Banff criteria): 6/87 (7%) showed high sCD30 versus 2/103 (2%) with sCD30 <100. This analysis became significant for anti-HLA immunization: 11 (13%) recipients developed anti-HLA class II antibodies in the first group (sCD30 >100) versus 1 (1%) in the second group (sCD30 <100; P < .01). A high pretransplantation sCD30 was not a significant risk factor for an acute rejection episode, but it seemed to be more predictive for antibody-mediated acute rejection and immunological graft loss. However, many recipients showed an increased pretransplantation concentration without any rejection episode or graft loss. Consequently, sCD30 pregraft measurements cannot be used as a predictor for acute kidney rejection among our transplant center, nor as an aid to adapt the immunosuppressive regimen.
Giannoli
C
C
Histocompatibility Laboratory, EFS Rhône Alpes, 1-3 rue du Vercors, 69364 Lyon Cédex 07, France. catherine.giannoli@efs.sante.fr
Bonnet
M C
MC
Perrat
G
G
Houillon
A
A
Reydet
S
S
Pouteil-Noble
C
C
Villar
E
E
Lefrançois
N
N
Morelon
E
E
Dubois
V
V
D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation / Q000276:immunology*; D012016:Reference Values
D015703:Antigens, CD; D015415:Biomarkers; D006681:HLA-D Antigens; D017730:Ki-1 Antigen