Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma.
Three quantitative and non-invasive techniques were used to monitor angiogenesis in Kaposi's sarcoma patients: thermography, laser Doppler imaging (LDI), and near-infrared spectroscopy. Before and after combination cytotoxic and anti-angiogenesis therapy, blood volume, oxygenated hemoglobin, temperature, and blood flow were analyzed. These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy.
Vogel
Abby
A
Laboratory of Integrative & Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. vogelab@mail.nih.gov
Dasgeb
Bahar
B
Hassan
Moinuddin
M
Amyot
Franck
F
Chernomordik
Victor
V
Tao
Yang
Y
Demos
Stavros G
SG
Wyvill
Kathleen
K
Aleman
Karen
K
Little
Richard
R
Yarchoan
Robert
R
Gandjbakhche
Amir H
AH
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D015203:Reproducibility of Results; D012514:Sarcoma, Kaposi / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013817:Thermography / Q000379:methods*