Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
Dioscin derivatives (1-12) with a variety of substitutions at the 6'-OH of the chacotriosyl residue and the 3',6'-anhydrosaponin derivatives (26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent dioscin, while their hemolytic activities were partially retained depending on the various 6'-O-substitutions.
Li
Wei
W
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Qiu
Zaozao
Z
Wang
Yibing
Y
Zhang
Yichun
Y
Li
Ming
M
Yu
Jia
J
Zhang
Lihong
L
Zhu
Ziyan
Z
Yu
Biao
B
D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D012503:Saponins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
D012503:Saponins; C019357:dioscin; D004144:Diosgenin