title: Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling.
abstract: Nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) have emerged as essential small molecules for cellular signal transduction owing largely to their ability to mediate oxidative posttranslational modifications (PTMs). Inventing new ways to track these small, diffusible, and reactive species with spatial and temporal resolution is a key challenge in elucidating their chemistry in living systems. Recent progress in the development of fluorescent probes that respond selectively to NO and H(2)O(2) produced at cell signaling levels offers a promising approach to interrogating their physiological production, accumulation, trafficking, and function.
authors.affiliation: Department of Chemistry, University of California, Berkeley, CA 94720, USA.
authors.forename: Evan W
authors.initials: EW
authors.lastname: Miller
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis / Q000378:metabolism*; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology
chemical_list: D005456:Fluorescent Dyes; D009569:Nitric Oxide; D006861:Hydrogen Peroxide