Childhood linear IgA bullous disease triggered by amoxicillin-clavulanic acid.
Linear immunoglobulin A bullous disease is an autoimmune subepidermal blistering disease that has been described in both children and adults. Reports have shown that as many as two-thirds of occurrences may be drug-induced. The offending drugs include antibiotics, predominantly vancomycin, nonsteroidal anti-inflammatory agents and diuretics. We report childhood linear immunoglobulin A bullous dermatosis developing following amoxicillin-clavulanic acid administration. The patient presented with characteristic blisters in an annular fashion, likened to a ''crown of jewels.'' The diagnosis was confirmed by the presence of a linear band of immunoglobulin A at the dermoepidermal junction on direct immunofluorescence. The lesions resolved with withdrawal of the drug, and systemic therapy was not required. We review the current literature and concepts of drug-induced linear immunoglobulin A bullous disease.
Ho
Jean Chin Ching
JC
National Skin Centre, Singapore. jeanho@nsc.gov.sg
Ng
Pei Lin Patricia
PL
Tan
Suat Hoon
SH
Giam
Yoke Chin
YC
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002675:Child, Preschool; D003875:Drug Eruptions / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology*
D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A; D019980:Amoxicillin-Potassium Clavulanate Combination