Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.
A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin cell signaling. Compounds 1 and 2 had IC50 values of 3.7 and 1.7 microM, respectively.
Feng
Yunjiang
Y
Natural Product Discovery, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Qld 4111, Australia.
Carroll
Anthony R
AR
Addepalli
Rama
R
Fechner
Gregory A
GA
Avery
Vicky M
VM
Quinn
Ronald J
RJ
D001315:Australia; D000460:Chlorophyta / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007328:Insulin / Q000378:metabolism; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D014641:Vanillic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D007328:Insulin; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D014641:Vanillic Acid