title: Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
abstract: The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.
authors.affiliation: Chemistry Department, Northwestern University, 2145 Sheridan Road, Evanston IL 60201, USA.
authors.forename: Chris V
authors.initials: CV
authors.lastname: Galliford
authors.forename: Karl A
authors.initials: KA
authors.lastname: Scheidt
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D001688:Biological Products; D007211:Indoles