title: Melatonin.
abstract: Melatonin is a neurohormone that is secreted by the pineal gland and known to impact the sleep-wake cycle. Melatonin is regarded to be a safe and natural sleep aid. Since many people with tinnitus suffer sleep disturbance, melatonin has been studied as a therapeutic agent for tinnitus. A review of the literature suggests that melatonin has a beneficial effect on tinnitus, especially for patients with sleep disturbance, but it does not seem to modify the strength or frequency of the tinnitus.
authors.affiliation: Clinical Outcomes Research Office, Department of Otolaryngology, Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, USA. piccirilloj@ent.wustl.edu
authors.forename: Jay F
authors.initials: JF
authors.lastname: Piccirillo
mesh_terms: D000818:Animals; D006801:Humans; D008550:Melatonin / Q000502:physiology* / Q000627:therapeutic use*; D012893:Sleep Wake Disorders / Q000150:complications / Q000188:drug therapy; D014012:Tinnitus / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D008550:Melatonin