title: Synthesis of a promising immunosuppressant: FR252921.
abstract: A concise and highly convergent synthesis of the promising immunosuppressant FR252921 was achieved by using optically active titanium complexes to control the configuration of the three stereogenic centers.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI, Centre National de la Recherche Scientifique, 10 rue Vauquelin, Paris Cedex 05, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Amans
authors.forename: Véronique
authors.initials: V
authors.lastname: Bellosta
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000143:Acids / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D017971:Tin Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000143:Acids; D000588:Amines; D002264:Carboxylic Acids; D004952:Esters; C474178:FR 252921; D007166:Immunosuppressive Agents; D007769:Lactams; D007783:Lactones; D017971:Tin Compounds; D014753:Vinyl Compounds; C031525:stannane