title: Cancer-targeting gene therapy using tropism-modified adenovirus.
abstract: Gene therapy has the potential to provide highly selective, curative cancer treatments without inducing systemic toxicity. Adenoviral vectors have been extensively used for cancer gene therapy because of their relatively high efficacy of gene transfer. However, gene transduction to cancer cells is limited by the necessity of using adenoviral type 5 vectors. This is because these vectors have a low transduction efficiency due to weak expression of the adenovirus receptor, coxsackie-adenovirus receptor (CAR), on cancer cells. Moreover, there may be side-effects to the treatment as normal cells also express CAR. In order to eradicate cancer cells without side-effects, the development of a targeting-vector is therefore crucial. In this review, the recent targeting strategies of adenoviral vectors for cancer gene therapy are summarized.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Fukuoka University, Sapporo Medical University, Japan. totanaka@fukuoka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Motomu
authors.initials: M
authors.lastname: Kuroki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hamada
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kato
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Shibaguchi
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
mesh_terms: D000256:Adenoviridae; D000818:Animals; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D011991:Receptors, Virus; D018523:Tropism
chemical_list: C568772:CLMP protein, mouse; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D008024:Ligands; D011991:Receptors, Virus