title: Treatment of trigeminal neuralgia with low doses of topiramate.
abstract: Topiramate was administered to eight patients with classical trigeminal neuralgia with or without previous symptomatic therapy with other antiepileptic drugs. The topiramate doses ranged from 50 to 100 mg a day, according to the clinical response and the reported side effects. Three patients had complete symptoms remission, three reported moderate improvement, and the treatment was not effective in two. The most frequently registered side effects were dizziness, somnolence and weight loss. Topiramate can be considered an alternative treatment for patients with trigeminal neuralgia.
authors.affiliation: Departamento de Patologia, Escola Superior de Ciências, Santa Casa de Misericórdia de Vitória, Avenida Nossa Senhora da penha 699, 29055-131 Vitória, ES, Brazil. renan-domingues@uol.com.br
authors.forename: Renan Barros
authors.initials: RB
authors.lastname: Domingues
authors.forename: Gustavo Wruck
authors.initials: GW
authors.lastname: Kuster
authors.forename: Camila Catherine Henriques
authors.initials: CC
authors.lastname: Aquino
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077236:Topiramate; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose