title: Quaternary ammonium chitosan derivative dynamic coating for the separation of veterinary sulfonamide residues by CE with field-amplified sample injection.
abstract: A quaternary ammonium chitosan, 2-hydroxypropyltrimethylammonium chloride chitosan (HACC), has been developed for the dynamic coating material in CE for the first time. It presented many advantages such as favorable water solubility, satisfactory coating efficiency, and EOF toward the anode at pH >7.0. Using the modified fused-silica capillary, sulfonamides (SAs), an important group of veterinary drugs, were separated and detected by CE combined with field-amplified sample injection (FASI). The LODs of sulfonamides with UV detection were less than 0.5 ng/mL. The proposed method has been applied to the determination of veterinary sulfonamide residues in samples such as chicken, beef, and honey with fast separation (15 sulfonamides within 20 min), low LODs (0.1-0.5 ng/mL), and good reliability compared to the criteria of China (GB/T 18932.17-2003).
authors.affiliation: Department of Chemistry, Wuhan University, Wuhan, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Hua-Shan
authors.initials: HS
authors.lastname: Zhang
authors.forename: Ling-Yan
authors.initials: LY
authors.lastname: Xiao
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Cui
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D048271:Chitosan; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D000644:Quaternary Ammonium Compounds; D013449:Sulfonamides / Q000302:isolation & purification*; D019155:Veterinary Drugs / Q000302:isolation & purification*
chemical_list: D000644:Quaternary Ammonium Compounds; D013449:Sulfonamides; D019155:Veterinary Drugs; D048271:Chitosan