title: New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes.
abstract: Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. llxu@ctgu.edu.cn
authors.forename: Lan-Lan
authors.initials: LL
authors.lastname: Xu
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.forename: Jun-Zhi
authors.initials: JZ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Fei-Jun
authors.initials: FJ
authors.lastname: Dan
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C524610:5-furost-delta(25(27))-en-1,2,3,4,5,6,7,22zeta,26-nonaol-26-O-glucopyranoside; C524609:5-furost-delta(25(27))-en-1,2,3,4,5,7,22zeta,26-octaol-6-one-26-O-glucopyranoside; D008070:Lipopolysaccharides; D012503:Saponins; D009569:Nitric Oxide