title: ChemBank: a small-molecule screening and cheminformatics resource database.
abstract: ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector.
authors.affiliation: Chemical Biology Program and Platform, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Kathleen Petri
authors.initials: KP
authors.lastname: Seiler
authors.forename: Gregory A
authors.initials: GA
authors.lastname: George
authors.forename: Mary Pat
authors.initials: MP
authors.lastname: Happ
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Bodycombe
authors.forename: Hyman A
authors.initials: HA
authors.lastname: Carrinski
authors.forename: Stephanie
authors.initials: S
authors.lastname: Norton
authors.forename: Steve
authors.initials: S
authors.lastname: Brudz
authors.forename: John P
authors.initials: JP
authors.lastname: Sullivan
authors.forename: Jeremy
authors.initials: J
authors.lastname: Muhlich
authors.forename: Martin
authors.initials: M
authors.lastname: Serrano
authors.forename: Paul
authors.initials: P
authors.lastname: Ferraiolo
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Tolliday
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clemons
mesh_terms: D001681:Biological Assay; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D019295:Computational Biology; D003196:Computer Graphics; D016208:Databases, Factual; D004353:Drug Evaluation, Preclinical; D020407:Internet; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012984:Software; D014584:User-Computer Interface
chemical_list: D004364:Pharmaceutical Preparations