[The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils].
OBJECTIVE
To investigate the expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils and its clinical significance.


METHODS
Under the light microscopy, HE and immunohistochemistry methods were used to show the morphology of HEVs, the number of T, B lymphocytes, the expression intensity of FasL and ICAM-1 in 17 patients with the idiopathic tonsillar hypertrophy (ITH) and in 20 patients with the chronic hypertrophic tonsillitis (CHT).


RESULTS
The expression intensity of ICAM-1 on the tonsillar HEVs in ITH group was significantly lower than that in CTH group (P < 0.05), but the intensity of FasL in ITH group was significantly higher than that in CHT group (P < 0.05).


CONCLUSIONS
FasL and ICAM-1 expression in the tonsillar HEVs contribute to the CHT and ITH. The former mainly makes IHT developed, and the latter promotes the process of the inflammation.
Liu
Yang
Y
Department of Otorhinolaryngology, Head and Neck Surgery,Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wang
Zhibin
Z
Yu
Haijing
H
Wang
Fang
F
Liu
Shenghong
S
Cui
Yonghua
Y
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004727:Endothelium / Q000098:blood supply; D053222:Fas Ligand Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D014069:Tonsillitis / Q000378:metabolism*; D014699:Venules / Q000378:metabolism*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D018799:Intercellular Adhesion Molecule-1