title: Coherence analysis over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy.
abstract: A total of 32 microwire electrodes were implanted bilaterally into the hippocampus of Sprague-Dawley rats, which were then stimulated in the manner prescribed for the chronic limbic epilepsy model. After the initial seizure brought on by the stimulation, the animals were recorded at a high sampling rate (approximately 12 kHz) for the entire duration of the latent period. Coherence was calculated across channels in both stimulated (and later seizing) animals and non-stimulated (and thus non-seizing control) animals. Average coherence over time was greatest in intrahemispherical electrode pairs in both stimulated and non-stimulated animals. However, the 200-800 Hz band displays increased coherence interhemispherically and up to 200 Hz band displays decreased coherence interhemispherically: this occurs only in stimulated animals.
authors.affiliation: Department of Biomedical Engineering, Florida University, Gainesville, FL, USA.
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Simonotto
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Myers
authors.forename: Michael D
authors.initials: MD
authors.lastname: Furman
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Norman
authors.forename: Zhao
authors.initials: Z
authors.lastname: Liu
authors.forename: Thomas B
authors.initials: TB
authors.lastname: DeMarse
authors.forename: Paul R
authors.initials: PR
authors.lastname: Carney
authors.forename: William L
authors.initials: WL
authors.lastname: Ditto
mesh_terms: D000465:Algorithms; D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D054022:Cerebrum / Q000503:physiopathology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology*; D008959:Models, Neurological; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time