[Cellular ageing, ageing and cancer].
Cellular division is essential for the survival of the multicellular organisms which contain renewable tissues. However, cellular division also puts the organisms in danger to develop any types of cancers. Cellular senescence has emerged in part as a tumor suppressor mechanism. Here we discuss the function and regulation of the tumor suppressor proteins INK4a/ARF in connection with replicative senescence, cancer and aging. double dagger.
Djabali
Malek
M
Chef d'équipe, Equipe Chromatine et mémoire cellulaire du CIML, Directeur de Recherche au CNRS, Centre d,Immunologie de Marseille-Luminy, Parc scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France. djabali@ciml.univ-mrs.fr
Agherbi
Hanane
H
D000368:Aged; D000375:Aging / Q000235:genetics / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000503:physiopathology*