title: A water-soluble, small molecular fluorescent sensor with femtomolar sensitivity for zinc ion.
abstract: A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to zinc ion and also exhibits high selectivity to zinc ion over other physiological relevant divalent metals in the presence of EDTA. X-ray crystal structure of zinc complex reveals that an acetic carboxylic group participates in coordination, which significantly enhances the affinity of 1 for zinc ion.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080 P. R. China.
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Wang
authors.forename: Quan
authors.initials: Q
authors.lastname: Gan
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Xue
authors.forename: Sheng-Hua
authors.initials: SH
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
mesh_terms: D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D012995:Solubility; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D014867:Water; D015032:Zinc