title: Comparative genome analyses of the pathogenic Yersiniae based on the genome sequence of Yersinia enterocolitica strain 8081.
abstract: This chapter represents a summary of the findings from the Yersinia enterocolitica strain 8081 whole genome sequence and the associated microarray analysis. Section 1 & 2 provide an introduction to the species and an overview of the general features of the genome. Section 3 identifies important regions within the genome which highlight important differences in gene function that separate the three pathogenic Yersinias. Section 4 describes genomic loci conferring important, species-specific, metabolic and virulence traits. Section 5 details extensive microarray data to provide an overview of species-specific core Y. enterocolitica gene functions and important insights into the intra-species differences between the high, low and non-pathogenic Y. enterocolitica biotypes.
authors.affiliation: The Pathogen Sequencing Unit, Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Cambridge, UK. nrt@sanger.ac.uk
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Thomson
authors.forename: Sarah
authors.initials: S
authors.lastname: Howard
authors.forename: Brendan W
authors.initials: BW
authors.lastname: Wren
authors.forename: Michael B
authors.initials: MB
authors.lastname: Prentice
mesh_terms: D002482:Cellulose / Q000096:biosynthesis / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics; D018899:CpG Islands; D004269:DNA, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D008715:Methionine / Q000378:metabolism; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D009876:Operon; D010802:Phylogeny; D013045:Species Specificity; D014774:Virulence / Q000235:genetics; D015007:Yersinia / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D015008:Yersinia enterocolitica / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D004269:DNA, Bacterial; D002482:Cellulose; D008715:Methionine