[Acute effects of fine particle on cardiovascular system of rats].
OBJECTIVE
To observe the effects of fine particle on cardiovascular system of rats and compare fine particle toxicity on rats suffered from different condition and find the possible toxicological mechanism of fine particle.


METHODS
Fine particle were collected using Thermo Anderson G-2.5 apparatus in Shanghai. Twenty-four spontaneous hypertension rats (SHR) and age-matched twenty-four WKY rats were used as subjects in order to study the effects of fine particle on cardiovascular system. The animals were divided into four groups and submitted to the instillation of saline and different dose fine particle. Twenty-four hours after instillation, direct measurements of arterial blood pressure and observation of electrocardiogram were obtained by catheterization of the carotid, and collected blood serum for measuring enzymes.


RESULTS
With the increase of the concentration of fine particle, blood pressures and heart rates of WKY rats and SHR significantly increased. In every treatment groups, the blood pressures and heart rates were higher than those of control groups. At the same time, not only in WKY rats but also in SHR, the levels of lactate dehydrogenase (LDH) and MB isoenzyme of creatine kinase (CK-MB) were increased with the concentration of fine particle, and the levels of two kinds of enzymes in exposure groups were more higher than those of control groups. Furthermore, the levels of two kinds of enzymes of SHR groups at the doses of different treatment were more than those of WKY rats.


CONCLUSIONS
The results showed that fine particle could be cardiovascular system toxicity for WKY rats and SHR, and SHR seemed more susceptible to fine particle than those of WKY rats.
Zhao
Jinzhuo
J
Key Laboratory of the Public Health and Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Cao
Qiang
Q
Qian
Xiaolin
X
Xie
Yuquan
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D052279:Creatine Kinase, MB Form / Q000097:blood*; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D052638:Particulate Matter; D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form