Protein translation, 2007.
Translation of RNA to protein is essential for life. It should perhaps not be surprising, therefore, that appropriate regulation of translation plays a key role in determining longevity. This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by signaling through the target of rapamycin kinase, in modulating aging and age-associated diseases.
Kaeberlein
Matt
M
Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA. kaeber@u.washington.edu
Kennedy
Brian K
BK
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000502:physiology; D008136:Longevity; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000378:metabolism; D019893:Ribosomal Protein S6 Kinases / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism / Q000502:physiology
D012269:Ribosomal Proteins; D011494:Protein Kinases; D019893:Ribosomal Protein S6 Kinases