CD10 expression in stromal cells of ameloblastoma variants.
OBJECTIVE
We performed an immunohistochemical study in a series of ameloblastomas with different histology to explore the existence of a correlation between CD10 immunoreactivity in peritumoral stromal cells and the type of ameloblastoma with a high risk of local recurrence.


METHODS
A total of 45 ameloblastomas (18 unicystic [UA], 4 peripheral [PA], 23 solid/multicystic [SA]) were evaluated. Cases showing immunoreactivity for CD10 in < and > or =10% of stromal cells around tumoral epithelial islands, were considered, respectively, negative and positive. Correlations between stromal CD10 expression and histopathologic types with low and high risk of recurrence were evaluated by statistical analysis.


RESULTS
SA cases showed a significantly higher percentage of stromal CD10-positive cells than the UA and PA variants. A strong intensity of immunostaining was observed only in SA.


CONCLUSIONS
Our results suggest that CD10 expression might be associated with stromal invasion in ameloblastoma variants with a high risk of recurrences.
Iezzi
Giovanna
G
Research Fellow, Dental School, University of Chieti-Pescara, Chieti-Pescara, Italy.
Piattelli
Adriano
A
Rubini
Corrado
C
Artese
Luciano
L
Goteri
Gaia
G
Fioroni
Massimiliano
M
Carinci
Francesco
F
D000564:Ameloblastoma / Q000145:classification* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000145:classification* / Q000276:immunology* / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000276:immunology; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D015260:Neprilysin / Q000096:biosynthesis*; D011379:Prognosis; D018709:Statistics, Nonparametric; D017154:Stromal Cells / Q000276:immunology / Q000473:pathology
D015260:Neprilysin