title: Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) gene that have significant associations with the pathogenesis of polycystic ovary syndrome (PCOS) in a Korean population.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  One hundred thirty-four patients with PCOS and 100 healthy women as controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Frequencies of genotypes for SNPs in VEGF gene, which were specifically expressed in a Korean population.
  
  
  RESULTS
  After genotypic analysis, we found that among 10 SNPs, one novel SNP at site +9812 and one known SNP at site +13553 have P values lower than .05 (+9812: odds ratio [95% confidence interval] 0.61 [0.39-0.95]; +13553: odds ratio [95% confidence interval] 0.59 [0.37-0.93]) and one haplotype (ht4) also has a P value in the significant range (odds ratio [95% confidence interval] 0.34 [0.16-0.74]).
  
  
  CONCLUSIONS
  We concluded that one novel SNP at +9812 site, one known SNP at +13553 site, and one selected haplotype in the VEGF gene have a high possibility of significant associations with the pathogenesis of PCOS in a Korean population.
authors.affiliation: Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea.
authors.forename: Eung-Ji
authors.initials: EJ
authors.lastname: Lee
authors.forename: Bermseok
authors.initials: B
authors.lastname: Oh
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Kuchan
authors.initials: K
authors.lastname: Kimm
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Park
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
mesh_terms: D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D005799:Genes, Dominant; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A