Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
4-Amino analogues prepared from beta-boswellic acid and 11-keto-beta-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
Shah
Bhahwal A
BA
Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.
Kumar
Ajay
A
Gupta
Pankaj
P
Sharma
Madhunika
M
Sethi
Vijay K
VK
Saxena
Ajit K
AK
Singh
Jaswant
J
Qazi
Ghulam N
GN
Taneja
Subhash C
SC
D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D029743:Boswellia / Q000737:chemistry; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects; D006131:Growth Inhibitors / Q000633:toxicity*; D006801:Humans; D014315:Triterpenes / Q000737:chemistry / Q000633:toxicity*
D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D014315:Triterpenes; C054625:boswellic acid