First trimester serum inhibin A in normal pregnant women.
OBJECTIVE
To establish reference ranges for maternal serum inhibin A in normal first trimester pregnant women.


METHODS
This was a cross-sectional study. We measured maternal serum inhibin A in normal pregnant women gestation age between 6(+0) and 14(+6) weeks using the enzyme-linked immunosorbent assay (ELISA) method. Maternal serum inhibin A was analyzed according to gestational ages (GA).


RESULTS
Serum of 300 pregnancies was analyzed and the outcome demonstrated the median of maternal serum inhibin A according to gestational age. The levels of maternal serum inhibin A during the 6(0)-6(+6) week of gestations are lowest when compared with other gestational age. The levels of maternal serum inhibin A during 9(0)-9(+6) week of gestations are maximal. Maternal serum inhibin A then declined until 14 weeks of gestation.


CONCLUSIONS
Serum inhibin A can be measured during the first trimester of pregnancy by using the recent ELISA technique. Our reference ranges might be useful for further studies, such as prediction of adverse pregnancy outcome in threatened abortion.
Phupong
Vorapong
V
Department of Obstetrics and Gynecology, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok, 10330, Thailand. vorapong.p@chula.ac.th
Hanprasertpong
Tharangrut
T
Honsawek
Sittisak
S
D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007265:Inhibins / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood* / Q000276:immunology; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D013785:Thailand
C422362:inhibin A; D007265:Inhibins