Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa.
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
Jung
Mankil
M
Department of Chemistry, Yonsei University, Seoul 120-749, Korea. mjung@yonsei.ac.kr
Park
Moonso
M
D000110:Acetylcholinesterase / Q000378:metabolism*; D031981:Agrimonia / Q000737:chemistry*; D000818:Animals; D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004593:Electrophorus; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D013055:Spectrophotometry, Infrared
D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D011522:Protons; D000110:Acetylcholinesterase