title: Fixation artefact in an intra-operative frozen section: a potential cause of misinterpretation.
abstract: The intra-operative histological assessment of fresh tissue can provide valuable diagnostic information and guide surgical management, however, even a limited exposure to standard fixation agents can potentially compromise analysis. Defined handling strategies should exist to facilitate the receipt of all specimens, in their optimal state, by the laboratory.
authors.affiliation: Division of Pathology, College of Medicine and Veterinary Medicine, The University of Edinburgh and Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh. Andrew.Thomson@luht.scot.nhs.uk
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Thomson
authors.forename: William A
authors.initials: WA
authors.lastname: Wallace
mesh_terms: D000369:Aged, 80 and over; D016477:Artifacts; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000601:surgery; D003951:Diagnostic Errors / Q000517:prevention & control; D005404:Fixatives; D005629:Frozen Sections / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D013048:Specimen Handling / Q000009:adverse effects
chemical_list: D005404:Fixatives