Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.
A meta-regression analysis was undertaken to evaluate the association between delta-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61 microg/dl. Using a random effects model, the pooled estimate was also significant at 1.51 microg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.
Zhao
Yang
Y
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Wang
Lu
L
Shen
Hong-Bing
HB
Wang
Zhong-Xu
ZX
Wei
Qing-Yi
QY
Chen
Feng
F
D000328:Adult; D002648:Child; D004781:Environmental Exposure; D006801:Humans; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000235:genetics; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000623:Porphobilinogen Synthase / Q000235:genetics*; D012044:Regression Analysis
D007854:Lead; D000623:Porphobilinogen Synthase