title: Mode of ventilation during cardiopulmonary bypass does not affect immediate postbypass oxygenation in pediatric cardiac patients.
abstract: OBJECTIVE
  To investigate the impact of different modes of ventilation during cardiopulmonary bypass (CPB) on immediate postbypass oxygenation in pediatric cardiac surgery.
  
  
  METHODS
  Prospective, randomized clinical trial.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  50 pediatric patients (18 girls, 32 boys), aged 4 months to 15 years, undergoing elective repair of congenital heart disease.
  
  
  METHODS
  Patients were randomized to receive one of 5 modes of ventilation during bypass. Groups 1 and 2 received high-frequency/low-volume ventilation with 100% (group 1) or 21% oxygen (group 2). Groups 3 and 4 received continuous positive airway pressure of 5 cm H(2)O with 100% (group 3) or 21% oxygen (group 4); and in group 5, each patient's airway was disconnected from the ventilator (passive deflation).
  
  
  METHODS
  Blood gas analysis and spirometry data were recorded 5 minutes before chest opening, 5 minutes before inducing bypass, 5 minutes after weaning from bypass, and 5 minutes after chest closure.
  
  
  RESULTS
  There were no differences in Pao(2) values among the 5 groups studied and at the different time points. Lung compliance was higher 5 minutes before bypass in group 1 versus group 5 (34 +/- 13 mL/cm H(2)O vs 20 +/- 9 mL/cm H(2)O; P = 0.048).
  
  
  CONCLUSIONS
  Mode of ventilation during CPB did not affect immediate postbypass oxygenation.
authors.affiliation: Department of Cardiothoracic Surgery, the Edith Wolfson Medical Center, Holon, Affiliated with the Sackler Medical School, Tel Aviv University, Tel Aviv 58100, Israel.
authors.forename: Lior
authors.initials: L
authors.lastname: Sasson
authors.forename: Alexander
authors.initials: A
authors.lastname: Sherman
authors.forename: Tiberiu
authors.initials: T
authors.lastname: Ezri
authors.forename: Sion
authors.initials: S
authors.lastname: Houri
authors.forename: Eli
authors.initials: E
authors.lastname: Ghilad
authors.forename: Ilan
authors.initials: I
authors.lastname: Cohen
authors.forename: Shmuel
authors.initials: S
authors.lastname: Evron
mesh_terms: D000293:Adolescent; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000517:prevention & control; D012121:Respiration, Artificial
chemical_list: D010100:Oxygen