title: New trends in the treatment of bone metastasis.
abstract: Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective therapies to inhibit the development or progression of bone metastases will have important clinical benefits. To achieve this goal understanding the mechanisms through which bone metastases develop and progress may provide targets to inhibit the metastases. In the past few years, there have been advances in both understanding the mechanisms through which bone metastases develop and how they impact bone remodeling. Additionally, gains in promising clinical strategies to target bone metastases have been developed. In this prospectus, we will discuss some of these advances.
authors.affiliation: Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA. etkeller@umich.edu
authors.forename: Evan T
authors.initials: ET
authors.lastname: Keller
authors.forename: Jinlu
authors.initials: J
authors.lastname: Dai
authors.forename: June
authors.initials: J
authors.lastname: Escara-Wilke
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Hall
authors.forename: Kathleen
authors.initials: K
authors.lastname: Ignatoski
authors.forename: Russell S
authors.initials: RS
authors.lastname: Taichman
authors.forename: Jill
authors.initials: J
authors.lastname: Keller
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology; D010014:Osteolysis / Q000628:therapy; D053244:Osteoprotegerin / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy; D053245:RANK Ligand / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D053244:Osteoprotegerin; D053245:RANK Ligand