Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.
Palit
Partha
P
Indian Institute of Chemical Biology, Infectious Diseases and Immunology Division, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Ali
Nahid
N
D000284:Administration, Oral; D017311:Amlodipine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D017737:Macrophages, Peritoneal / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D016896:Treatment Outcome
D000981:Antiprotozoal Agents; D004095:Dihydropyridines; D017311:Amlodipine; C038806:1,4-dihydropyridine