Mode of ventilation during cardiopulmonary bypass does not affect immediate postbypass oxygenation in pediatric cardiac patients.
OBJECTIVE
To investigate the impact of different modes of ventilation during cardiopulmonary bypass (CPB) on immediate postbypass oxygenation in pediatric cardiac surgery.


METHODS
Prospective, randomized clinical trial.


METHODS
University hospital.


METHODS
50 pediatric patients (18 girls, 32 boys), aged 4 months to 15 years, undergoing elective repair of congenital heart disease.


METHODS
Patients were randomized to receive one of 5 modes of ventilation during bypass. Groups 1 and 2 received high-frequency/low-volume ventilation with 100% (group 1) or 21% oxygen (group 2). Groups 3 and 4 received continuous positive airway pressure of 5 cm H(2)O with 100% (group 3) or 21% oxygen (group 4); and in group 5, each patient's airway was disconnected from the ventilator (passive deflation).


METHODS
Blood gas analysis and spirometry data were recorded 5 minutes before chest opening, 5 minutes before inducing bypass, 5 minutes after weaning from bypass, and 5 minutes after chest closure.


RESULTS
There were no differences in Pao(2) values among the 5 groups studied and at the different time points. Lung compliance was higher 5 minutes before bypass in group 1 versus group 5 (34 +/- 13 mL/cm H(2)O vs 20 +/- 9 mL/cm H(2)O; P = 0.048).


CONCLUSIONS
Mode of ventilation during CPB did not affect immediate postbypass oxygenation.
Sasson
Lior
L
Department of Cardiothoracic Surgery, the Edith Wolfson Medical Center, Holon, Affiliated with the Sackler Medical School, Tel Aviv University, Tel Aviv 58100, Israel.
Sherman
Alexander
A
Ezri
Tiberiu
T
Houri
Sion
S
Ghilad
Eli
E
Cohen
Ilan
I
Evron
Shmuel
S
D000293:Adolescent; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000517:prevention & control; D012121:Respiration, Artificial
D010100:Oxygen