title: Deep brain stimulation electrode anchoring using BioGlue((R)), a protective electrode covering, and a titanium microplate.
abstract: The authors present an easily applicable deep brain stimulation (DBS) electrode anchoring technique for use in human and experimental animals. The anchoring technique combines the use of fibrin glue, a two-component surgical adhesive (BioGlue), a protective electrode covering, and a titanium microplate. The BioGlue (CryoLife International, Inc., Kennesaw, GA, USA) hinders unwanted electrode movement during the electrode fixation step and seals the burr hole, while the protective electrode covering protects the electrode under the titanium microplate which keeps the electrode in a permanent position. The described technique further has the advantage of being cosmetically acceptable to the human patient, and furthermore it perfectly adapts to the smaller and irregular-shaped skull in experimental animals. The described technique has clinically been used to implant DBS-electrodes in the subthalamic nucleus for Parkinson disease and is the preferred DBS-electrode anchoring technique for our experimental DBS-studies in the Göttingen minipig.
authors.affiliation: Department of Neurobiology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark. cb@ana.au.dk <cb@ana.au.dk>
authors.forename: Carsten R
authors.initials: CR
authors.lastname: Bjarkam
authors.forename: Rasmus L
authors.initials: RL
authors.lastname: Jorgensen
authors.forename: Kristian N
authors.initials: KN
authors.lastname: Jensen
authors.forename: Niels Aa
authors.initials: NA
authors.lastname: Sunde
authors.forename: Jens-Christian H
authors.initials: JC
authors.lastname: Sørensen
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D004567:Electrodes, Implanted; D005260:Female; D006168:Guinea Pigs; D011506:Proteins; D013238:Stereotaxic Techniques; D014025:Titanium
chemical_list: C472676:Bio-glue; D011506:Proteins; D014025:Titanium