Outlook for the use of focused shock waves and pulsed electric fields in the complex treatment of malignant neoplasms.
The experimental studies the synchronous action of electric field microsecond range with amplitude within the range of 1-7 kV/sm and shock waves with pressure before 100 MPa on cells membrane permeability of the mouse's ascitic tumors in vitro have shown the intensification the efficiency of the forming the irreversible pores under synchronous action. Thereby, enabling the electric field in the compression phase of shock wave pulse which can essentially reduce the electric field intensity required for breakdown cell membrane. In usual condition at amplitude of electric field, specified above, electric breakdown membrane carries basically reversible nature. At the same time in the pressure field tension phase of shock-wave pulse reversible pores, created by electric field, can grow before sizes, under which wholeness membrane is not restored. Under simultaneous action on cellular suspension the shock wave and electric field with moderate intensity cells survival is reduced in 5 once in contrast with occuring at different time's action, and in 10 once in contrast with checking. The most sensitive to influence by under study fields are cells in phase of the syntheses DNA, preparation to fission and in phase of the mitosis. Thereby, continuation of the studies on use synchronous action shock waves and pulsed electric fields in complex treatment of the tumors introduces perspective.
Garilevich
B A
BA
Central Air Force Clinical Hosp., Moscow, Russia. medic-air@mtu-net.ru
Andrianov
Yu V
YV
Olefir
Yu V
YV
Zubkov
A D
AD
Rotov
A E
AE
D000162:Acoustics; D000465:Algorithms; D002462:Cell Membrane / Q000378:metabolism; D004566:Electrodes; D004574:Electromagnetic Fields; D004867:Equipment Design; D006801:Humans; D008280:Magnetics; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010539:Permeability; D011312:Pressure; D012867:Skin / Q000473:pathology; D013997:Time Factors