In-vivo lung cancer imaging in mice using 360 degrees free-space fluorescence molecular tomography.
We present the development and performance characteristics of a free-space fluorescence tomography system. The imaging system can capture complete angle projections of photons propagating through tissue in transillumination using a CCD camera. Experimental data on imaging lung cancer are presented. Overall, this imaging approach can offer unprecedented imaging performance in fluorescence molecular tomography of small animals.
Deliolanis
Nikolaos
N
Laboratory for Bio-optics & Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA.
Lasser
Tobias
T
Niedre
Mark
M
Soubret
Antoine
A
Ntziachristos
Vasilis
V
D000465:Algorithms; D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D015336:Molecular Probe Techniques / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D041622:Tomography, Optical / Q000295:instrumentation*; D051598:Whole Body Imaging / Q000295:instrumentation* / Q000379:methods