title: Prophylactic antiemetic effect of midazolam after middle ear surgery.
abstract: OBJECTIVE
  To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
  
  
  METHODS
  A prospective, randomized, double-blind, placebo-controlled study.
  
  
  METHODS
  Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
  
  
  RESULTS
  Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
  
  
  CONCLUSIONS
  Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.
authors.affiliation: Department of Anesthesiology, Kyungpook National University Hospital, Jung-Gu, Daegu, Republic of Korea.
authors.forename: Jae Sik
authors.initials: JS
authors.lastname: Jung
authors.forename: Jun Sik
authors.initials: JS
authors.lastname: Park
authors.forename: Si Oh
authors.initials: SO
authors.lastname: Kim
authors.forename: Dong Gun
authors.initials: DG
authors.lastname: Lim
authors.forename: Sung Sik
authors.initials: SS
authors.lastname: Park
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Kwak
authors.forename: Jin Duck
authors.initials: JD
authors.lastname: Cho
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Jeon
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000592:standards* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D014433:Tympanoplasty
chemical_list: D000932:Antiemetics; D006993:Hypnotics and Sedatives; D008874:Midazolam