title: The relationship between IL-1 gene polymorphism and marginal bone loss around dental implants.
abstract: OBJECTIVE
  Early marginal bone loss around dental implants has been found during the bone healing period before stage II surgery despite a lack of apparent cause, and the etiology of this bone loss is unclear. This study was designed to investigate whether interleukin-1 gene polymorphism is associated with the marginal bone loss around the implants before stage II.
  
  
  METHODS
  One hundred forty-three implants were placed in 59 patients. The patients were divided into 2 groups: 1) test group: with 1 or more marginal bone loss greater than 0.5 mm; and 2) control group: with marginal bone resorption less than 0.5 mm. Polymorphisms of the IL-1alpha and IL-1beta genes (IL-1A-889, IL-1B-511, and IL-1B+3954) were detected by restriction fragment length polymorphism using Ncol, AvaI, and TaqI digestion after polymerase chain reactions.
  
  
  RESULTS
  The frequency of IL-1B-511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (-) group (P < .05). Multiple logistic regressions showed the OR of the II/II versus the I/I+I/II of the IL-1B-511 genotype was 3.933 between the 2 groups. The difference was statistically significant (P < .05). There was no significant difference between the other risk factors.
  
  
  CONCLUSIONS
  These results suggest that the IL-1B-511 II/II genotype in individuals is associated with early marginal bone loss around implants.
authors.affiliation: Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Ying-He
authors.initials: YH
authors.lastname: Lin
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Xuan
authors.initials: X
authors.lastname: Lu
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: Guan
authors.forename: Yi
authors.initials: Y
authors.lastname: Man
authors.forename: Na
authors.initials: N
authors.lastname: Wei
authors.forename: Yong-Yue
authors.initials: YY
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D015921:Dental Implants; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011862:Radiography, Panoramic; D012907:Smoking
chemical_list: D015921:Dental Implants; D007375:Interleukin-1; D053582:Interleukin-1alpha; D053583:Interleukin-1beta