Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents.
The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.
Silva Lourenço
Maria Cristina
MC
Instituto de Pesquisas Clínica Evandro Chagas-IPEC, Av. Brasil, 4365 Manguinhos Rio de Janeiro, RJ, Brazil.
Rodrigues Vicente
Felipe
F
de Oliveira Henriques
Maria das Graças Muller
Md
Peixoto Candéa
André Luis
AL
Borges Gonçalves
Raoni Schroeder
RS
Nogueira
Thais Cristina M
TC
de Lima Ferreira
Marcelle
M
Nora de Souza
Marcus Vinícius
MV
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
D000081:Acetamides; D000995:Antitubercular Agents; D013876:Thiophenes