title: Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth.
abstract: Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.
authors.affiliation: Division of Pediatric Hematology/Oncology, Oregon Health & Science University, Portland, Oregon, USA. vflood@mcw.edu
authors.forename: Veronica H
authors.initials: VH
authors.lastname: Flood
authors.forename: Faith C
authors.initials: FC
authors.lastname: Galderisi
authors.forename: Stefanie R
authors.initials: SR
authors.lastname: Lowas
authors.forename: Angela
authors.initials: A
authors.lastname: Kendrick
authors.forename: Lynn K
authors.initials: LK
authors.lastname: Boshkov
mesh_terms: D015942:Factor VIIa / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D014812:Vitamin K / Q000627:therapeutic use*; D014813:Vitamin K Deficiency / Q000097:blood / Q000517:prevention & control*; D006475:Vitamin K Deficiency Bleeding / Q000188:drug therapy* / Q000209:etiology*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D014815:Vitamins; D014812:Vitamin K; C103587:recombinant FVIIa; D015942:Factor VIIa