title: Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.
abstract: Control of Yops secretion in pathogenic Yersinia is achieved at several levels. These levels likely include transcriptional, post-transcriptional, translational and secretional controls. Secretion control appears to be mediated by two pathways. One pathway involves YopN and proteins that interact with YopN. The second pathway consists of LcrG and its interaction with LcrV. LcrV is a postive regulator of Yops secretion that exerts control over Yops secretion by negating the secretion blocking role of LcrG. However, the intersection of these two control pathways is not understood. Recent work has allowed the development of a speculative model that brings YopN-mediated and LcrG-LcrV-mediated control together in the context of the ability of the needle complex to respond to Ca2+.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine and Health Sciences, University of North Dakota, USA.
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Hamad
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Nilles
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D005798:Genes, Bacterial; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation; D052899:Pore Forming Cytotoxic Proteins / Q000235:genetics / Q000502:physiology*; D053038:Quorum Sensing; D015398:Signal Transduction; D015010:Yersinia pestis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C088009:LcrG protein, Yersinia; C043908:LcrV protein, Yersinia; D008565:Membrane Proteins; D052899:Pore Forming Cytotoxic Proteins; C070015:YopN protein, Yersinia