[Weekly dosage of docetaxel combined with cisplatin and 5-fluorouracil in the treatment of advanced gastric cancer].
OBJECTIVE
To observe the effects and toxicity of docetaxel given once weekly combined with cisplatin and 5-fluororacil in the treatment of advanced gastric cancer (AGC).


METHODS
Thirty-one patients with AGC were given docetaxel at 35 mg/m square by intravenous infusion completed in 1 h on the 1st, 8th and 15th days. Cisplatin was given at 20 mg/m square for 4 h between the 2nd and 6th days, during which time 5-fluororacil was also given at 750 mg/m square for 24 h. One treatment cycle lasted for 28 days and 2 consecutive cycles were administered.


RESULTS
In the 31 patients available for therapeutic effect evaluation, the overall effective rate was 48.4%. The effective rate in patients without previous treatments was 64.7% (CR in 2 cases), and 28.6% in the retreated patients. The median TTP, median survival time and one-year survival rate were 6 months, 11 months and 41.9%, respectively. The main toxic reactions of the combined treatment were myelosuppression, gastrointestinal tract reaction and alopecia of mostly grade 1 or 2.


CONCLUSIONS
Weekly dosage of docetaxel combined with cisplatin and 5-fluororacil is an effective regimen for AGC with only mild toxic reactions and good patient tolerance.
Zhang
Ai-Min
AM
Department of Oncology, Tingzhou Hospital of Fujian Province, Longyan 366300, China. Zhangaimin@csco.org.cn
Ye
Shen
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil