[Increased plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients].
OBJECTIVE
This study investigates the plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients.


METHODS
Patients were scruited according to JNC-7 and divided into three groups: 74 normotensive subjects (NT group, 38 males, mean age 47.15 +/- 7.77 years old); 51 prehypertensive patients (PH group, 29 males, mean age 47.82 +/- 5.16 years old) and 71 essential hypertensive patients (EH group, 37 males, mean age 48.25 +/- 7.97 years old). Serum lipids and plasma angiotensin II (Ang II), endothelin (ET), vasopressin (AVP), calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GPX) by radioimmunoassay and enzyme linked immunosorbent assay.


RESULTS
Serum Lipids (TG, CHO and LDL) were significantly higher in the PH and EH groups compared to NT group (all P < 0.05). Ang II, AVP and ET were significantly increased while CGRP decreased in the EH group than that in NT group (all P < 0.05). SOD was significantly lower while GPX significantly higher. Further more, in the PH and EH groups than those in the NT group (all P < 0.05).


CONCLUSIONS
SOD was reduced and GPX increased in prehypertensive patients.
Wang
Zuo-guang
ZG
Division of Hypertension, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing Institute of Heart, Lung, Vessel Diseases, Beijing 100029, China.
Liu
Jie-lin
JL
Liu
Ya
Y
Wen
Shao-jun
SJ
Wen
Jie
J
Liu
Ya-ping
YP
Chen
Xin-jun
XJ
Wu
Zhao-su
ZS
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D000975:Antioxidants; D001794:Blood Pressure / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D016022:Case-Control Studies; D016232:Endothelins / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000097:blood; D010949:Plasma / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood*; D014667:Vasopressins / Q000097:blood
D000975:Antioxidants; D016232:Endothelins; D014667:Vasopressins; D000804:Angiotensin II; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D015740:Calcitonin Gene-Related Peptide