title: Temperature evolution during compaction of pharmaceutical powders.
abstract: A numerical approach to the prediction of temperature evolution in tablet compaction is presented here. It is based on a coupled thermomechanical finite element analysis and a calibrated Drucker-Prager Cap model. This approach is capable of predicting transient temperatures during compaction, which cannot be assessed by experimental techniques due to inherent test limitations. Model predictions are validated with infrared (IR) temperature measurements of the top tablet surface after ejection and match well with experiments. The dependence of temperature fields on speed and degree of compaction are naturally captured. The estimated transient temperatures are maximum at the end of compaction at the center of the tablet and close to the die wall next to the powder/die interface.
authors.affiliation: Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA. azavalia@coe.drexel.edu
authors.forename: Antonios
authors.initials: A
authors.lastname: Zavaliangos
authors.forename: Steve
authors.initials: S
authors.lastname: Galen
authors.forename: John
authors.initials: J
authors.lastname: Cunningham
authors.forename: Denita
authors.initials: D
authors.lastname: Winstead
mesh_terms: D002138:Calibration; D007259:Infrared Rays; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets; D013696:Temperature
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets