A novel alkaloid from the fruits of Evodia officinalis.
Studies on the fruits of Evodia officinalis yielded a new quinazolinedione alkaloid, wuchuyuamide III (1), together with known alkaloids, goshuyuamide II (2), evodiamine and rutaecarpine. Their structures were elucidated by means of 1D and 2D NMR spectroscopic analysis. Wuchuyuamide III (1) and goshuyuamide II (2) showed modest cytotoxicity against HeLa and HT1080 cell lines.
Jin
Hui-Zi
HZ
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China. kimhz@sjtu.edu.cn
Du
Jing-Ling
JL
Zhang
Wei-Dong
WD
Chen
Hai-Sheng
HS
Lee
Jeong-Hyung
JH
Lee
Jung-Joon
JJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D032086:Evodia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids