Efficacy of renal preservation: comparative study of Celsior and University of Wisconsin solutions.
OBJECTIVE
We sought to compare the efficacy of Celsior and University of Wisconsin (UW) solutions on the perfusion and cold storage of renal grafts for human transplantation.


METHODS
Retrospective analyses of 313 kidney transplants were performed between 2002 and 2005; group A (n = 160), UW solution and group B (n = 153), Celsior solution were used in the preservation of the organs. The mean donor age was lower in group B (group A = 42.67 years vs group B = 38.96 years; P < .05), living donors were more frequent in the UW group (group A = 10% vs group B = 0.9%; P < .001). Multiorgan procurement procedures were more common in the Celsior group (group A = 75% vs group B = 81.7%; P < .001). Recipients with no associated comorbidities were more frequent in the UW group (group A = 50% vs group B = 36%; P < .001). Recipient mean age, cold ischemia time, and HLA matches were comparable.


RESULTS
Delayed graft function (group A = 22.7% vs group B = 20.6%), acute rejections (group A = 21.4% vs group B = 18.4%), and serum creatinine at 6 months (group A = 1.75 vs group B = 1.67 mg/dL), 1 year (group A = 1.47 vs group B = 1.74 mg/dL), and 2 years (group A = 1.43 vs group B = 1.58 mg/dL) showed no differences (P = NS). Graft (group A = 82.23% vs group B = 84.11%) and patient (group A = 93% vs group B = 93.69%) survivals at 3 years were similar (P = NS). There were no differences in the causes of graft loss.


CONCLUSIONS
The efficacy of UW and Celsior solutions is equivalent in the cold storage and renal preservation for transplantation.
Nunes
P
P
Department of Urology and Renal Transplantation, Hospitais da Universidade de Coimbra, 3000 Coimbra, Portugal. ptnunes@gmail.com
Mota
A
A
Figueiredo
A
A
Macário
F
F
Rolo
F
F
Dias
V
V
Parada
B
B
D000241:Adenosine; D000493:Allopurinol; D002102:Cadaver; D004187:Disaccharides; D004573:Electrolytes; D005500:Follow-Up Studies; D005971:Glutamates; D005978:Glutathione; D006085:Graft Survival / Q000502:physiology; D006639:Histidine; D006801:Humans; D007328:Insulin; D007668:Kidney; D016030:Kidney Transplantation / Q000502:physiology*; D008353:Mannitol; D019188:Organ Preservation Solutions; D011887:Raffinose; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose