title: Time-varying closed-loop modeling of autonomic control in pediatric obstructive sleep apnea syndrome during cold face stimulation.
abstract: Adults with obstructive sleep apnea syndrome (OSAS) are known to have impaired autonomic function but the corresponding effects in children appear to be more subtle. Model-based analysis of the cardiovascular response to cold face test (CFT) was used to quantify daytime autonomic dysfunction. The increase in transfer gain between respiration and RRI was not different between controls and OSAS. However, the transfer gain between "surrogate cardiac output" (pulse pressure+R-R interval) and systolic blood pressure (SBP) and the transfer gain between cardiac output and SBP both increased significantly in controls but not in OSAS during CFT. These findings suggest that the parasympathetic function remains relatively normal in pediatric OSAS, but cardiovascular sympathetic reactivity is impaired.
authors.affiliation: Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Chaicharn
authors.forename: Z
authors.initials: Z
authors.lastname: Lin
authors.forename: M L
authors.initials: ML
authors.lastname: Chen
authors.forename: T G
authors.initials: TG
authors.lastname: Keens
authors.forename: S L
authors.initials: SL
authors.lastname: Davidson Ward
authors.forename: M K
authors.initials: MK
authors.lastname: Khoo
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure; D002648:Child; D004562:Electrocardiography; D005145:Face; D006801:Humans; D008954:Models, Biological; D010812:Physical Stimulation; D012143:Respiratory Physiological Phenomena; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000628:therapy*