title: Two step synthesis of a non-symmetric acetylcholinesterase reactivator.
abstract: The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
authors.affiliation: Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
authors.forename: Kamil
authors.initials: K
authors.lastname: Musilek
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Dohnal
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Jan
authors.initials: J
authors.lastname: Marek
authors.forename: Vit
authors.initials: V
authors.lastname: Koleckar
mesh_terms: D002801:Cholinesterase Reactivators / Q000138:chemical synthesis*; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis*; D011726:Pyridinium Compounds / Q000138:chemical synthesis*
chemical_list: C508944:(E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide; D002801:Cholinesterase Reactivators; D006842:Hydrocarbons, Brominated; D011726:Pyridinium Compounds