title: Design and evaluation of anacardic acid derivatives as anticavity agents.
abstract: On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and tested for their antibacterial activity against Streptococcus mutans ATCC 25175. Among them, 6-(4',8'-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 microg/ml.
authors.affiliation: Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa. igreen@uwc.ac.za
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Green
authors.forename: Felismino E
authors.initials: FE
authors.lastname: Tocoli
authors.forename: Sang Hwa
authors.initials: SH
authors.lastname: Lee
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nihei
authors.forename: Isao
authors.initials: I
authors.lastname: Kubo
mesh_terms: D048729:Anacardic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003731:Dental Caries / Q000517:prevention & control*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical
chemical_list: D048729:Anacardic Acids; D000900:Anti-Bacterial Agents; C088115:anacardic acid