Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology.
Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.
Han
Jae-Joon
JJ
School of Electrical & Computer Engineering, Purdue University, West Lafayette, IN 47907-2035, USA.
Plawecki
Martin H
MH
Doerschuk
Peter C
PC
Ramchandani
Vijay A
VA
O'Connor
Sean
S
D000465:Algorithms; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003198:Computer Simulation; D000431:Ethanol / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000187:drug effects; D008962:Models, Theoretical; D012119:Respiration / Q000187:drug effects*; D018570:Risk Assessment; D014018:Tissue Distribution; D014116:Toxicology / Q000379:methods*
D000431:Ethanol