title: Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library.
abstract: A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC(90) value of 12.5 microg/mL.
authors.affiliation: Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Dianqing
authors.initials: D
authors.lastname: Sun
authors.forename: Victoria
authors.initials: V
authors.lastname: Jones
authors.forename: Elizabeth I
authors.initials: EI
authors.lastname: Carson
authors.forename: Robin E B
authors.initials: RE
authors.lastname: Lee
authors.forename: Michael S
authors.initials: MS
authors.lastname: Scherman
authors.forename: Michael R
authors.initials: MR
authors.lastname: McNeil
authors.forename: Richard E
authors.initials: RE
authors.lastname: Lee
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019151:Peptide Library; D013329:Structure-Activity Relationship; D014529:Uridine / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D019151:Peptide Library; D014529:Uridine