Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.
Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.
Lowenhaupt
Elizabeth A
EA
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. elowenhaupt@post.harvard.edu
Matson
Kelly
K
Qureishi
Bushra
B
Saitoh
Akihiko
A
Pugatch
David
D
D000480:Alkynes; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D048588:Benzoxazines / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002648:Child; D003521:Cyclopropanes; D065702:Cytochrome P-450 CYP2B6; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006579:Heterozygote; D006801:Humans; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics; D017354:Point Mutation; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D010089:Oxidoreductases, N-Demethylating; C098320:efavirenz