title: CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk.
abstract: OBJECTIVE
  This study was conducted to evaluate the potential role of CASP8 genetic polymorphisms in the etiology of breast cancer in a case-control study, Korea.
  
  
  METHODS
  Incident breast cancer cases confirmed histologically (n = 1,599) were recruited from two hospitals in Seoul during 2001-2005. Control subjects (n = 1,536) were selected from the Health Examinee Cohort from Seoul and Gyeonggi Province surrounding Seoul, Korea. Three SNPs (D302H D > H, 5'-UTR C > T, and K337K G > A) were genotyped by the primer extension assay. The CASP8 D302H, which was not polymorphic in 48 samples, was excluded in further genotyping. Odds ratios and 95% confidential intervals (95% CIs) were estimated by unconditional logistic regression model adjusted for age at enrollment, education, age at first full-term pregnancy, cigarette smoking, and family history of breast cancer.
  
  
  RESULTS
  The 5'-UTR T allele containing genotypes (CT/TT) were associated with an increased risk of breast cancer, compared with those with the CC genotype (OR = 1.13, 95% CI = 0.95-1.34; and OR = 1.48, 95% CI = 1.04-2.10, respectively; P-trend = 0.02). When stratified by the estrogen and progesterone receptor status, the association between the 5'-UTR T allele and breast cancer risk was prominent in ER(+) and PR(+) cases among pre-menopausal women (OR = 1.31, 95% CI = 1.00-1.72 and OR = 1.40, 95% CI = 1.06-1.85, respectively), whereas the association was found prominent in ER(-) or PR(-) cases (OR = 1.32, 95% CI = 0.93-1.87 and OR = 1.42, 95% CI = 1.04-1.94, respectively) among post-menopausal women.
  
  
  CONCLUSIONS
  Our results thus suggest that the CASP8 5'-UTR C > T are associated with breast cancer risks and the effect may be modified by estrogen and progesterone receptor status.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Chongno-Gu, Seoul, Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Han
authors.forename: Kyoung-Mu
authors.initials: KM
authors.lastname: Lee
authors.forename: Ji-Yeob
authors.initials: JY
authors.lastname: Choi
authors.forename: Sue Kyung
authors.initials: SK
authors.lastname: Park
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Dong-Young
authors.initials: DY
authors.lastname: Noh
authors.forename: Sei-Hyun
authors.initials: SH
authors.lastname: Ahn
authors.forename: Wonshik
authors.initials: W
authors.lastname: Han
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
authors.forename: Eunhee
authors.initials: E
authors.lastname: Ha
authors.forename: Keun-Young
authors.initials: KY
authors.lastname: Yoo
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D020121:5' Untranslated Regions; D000328:Adult; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012306:Risk
chemical_list: D020121:5' Untranslated Regions; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D053181:Caspase 8