The peripeduncular nucleus: a novel target for deep brain stimulation?
The pedunculopontine nucleus, a promising new target for deep brain stimulation in Parkinson's disease, straddles the pontomesencephalic junction--unfamiliar territory to most functional neurosurgeons. This contribution reviews the anatomy of the pedunculopontine and peripeduncular nuclei. Given the reported findings of Mazzone et al. in NeuroReport, the authors postulate that the peripeduncular nucleus might be of previously unexpected clinical relevance.
Zrinzo
Ludvic
L
Zrinzo
Laurence
L
Hariz
Marwana
M
D000818:Animals; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy; D011149:Pons / Q000033:anatomy & histology*; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology*