title: Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds.
abstract: A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.
authors.affiliation: Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria. norbert.haider@univie.ac.at
authors.forename: Norbert
authors.initials: N
authors.lastname: Haider
authors.forename: Tamara
authors.initials: T
authors.lastname: Kabicher
authors.forename: Johann
authors.initials: J
authors.lastname: Käferböck
authors.forename: Angelika
authors.initials: A
authors.lastname: Plenk
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry; D010793:Phthalazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D010793:Phthalazines; D010165:Palladium