Synthesis and antifungal bioactivities of 3-alkylquinazolin- 4-one derivatives.
A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.
Ouyang
Guiping
G
Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China. oygp710@163.com
Zhang
Peiquan
P
Xu
Gangfang
G
Song
Baoan
B
Yang
Song
S
Jin
Linhong
L
Xue
Wei
W
Hu
Deyu
D
Lu
Ping
P
Chen
Zhuo
Z
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D005874:Gibberella / Q000187:drug effects; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D052999:Quinazolinones