title: Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis.
abstract: OBJECTIVE
  Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.
  
  
  METHODS
  OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.
  
  
  RESULTS
  There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.
  
  
  CONCLUSIONS
  This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs).
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada. christelle.boileau@umontreal.ca
authors.forename: C
authors.initials: C
authors.lastname: Boileau
authors.forename: J
authors.initials: J
authors.lastname: Martel-Pelletier
authors.forename: F
authors.initials: F
authors.lastname: Abram
authors.forename: J-P
authors.initials: JP
authors.lastname: Raynauld
authors.forename: E
authors.initials: E
authors.lastname: Troncy
authors.forename: M-A
authors.initials: MA
authors.lastname: D'Anjou
authors.forename: M
authors.initials: M
authors.lastname: Moreau
authors.forename: J-P
authors.initials: JP
authors.lastname: Pelletier
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000379:methods; D020370:Osteoarthritis, Knee / Q000473:pathology*; D054850:Osteophyte / Q000473:pathology; D012720:Severity of Illness Index