Gold(I)-catalyzed three-component additions of 2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols: an efficient access to 3-oxabicyclo[3.1.0]hexanes.
Catalyzed by gold(I), (E)- and (Z)-2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols underwent three-component addition reactions to produce 3-oxabicyclo[3.1.0]hexanes in high yields and moderate diastereoselectivities under mild conditions. A plausible mechanism based on an intermolecular tandem hydroalkoxylation/Prins-type reaction pathway has been proposed.
Tian
Guo-Qiang
GQ
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China.
Shi
Min
M