Anti-eosinophilic effect of Lafoensia pacari in toxocariasis.
We previously reported the anti-inflammatory activity of Lafoensia pacari extract in Toxocara canis infection, a model of systemic IL-5-dependent eosinophil migration. In the present study, we describe the kinetics of the anti-inflammatory activity of L. pacari extract and compare it with dexamethasone. T. canis-infected mice were submitted to different treatment protocols and the cells present in bronchoalveolar space and peritoneal cavity were collected at the end of each treatment period. The results showed that L. pacari extract effectively inhibited eosinophil migration only when the treatment was initiated before the peak of eosinophil migration (1st to 18th; 12th to 18th and 12th to 24th day post-infection). When eosinophil migration was established, administration of L. pacari extract had no effect on it (treatment 18th to 24th day post-infection). Dexamethasone was effective in inhibiting eosinophil migration in all periods studied. We suggest that L. pacari extract can potentially be a natural alternative treatment of eosinophilic diseases.
Rogerio
A P
AP
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Sá-Nunes
A
A
Albuquerque
D A
DA
Soares
E G
EG
Faccioli
L H
LH
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002465:Cell Movement / Q000187:drug effects; D003907:Dexamethasone / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004804:Eosinophils / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008099:Liver / Q000473:pathology; D029561:Lythraceae / Q000737:chemistry*; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011897:Random Allocation; D014120:Toxocariasis / Q000188:drug therapy* / Q000473:pathology
D010936:Plant Extracts; D003907:Dexamethasone