Two new lanostanoids from Ganoderma resinaceum.
Two new lanostane triterpenoids, 3-epipachymic acid (3alpha-acetoxy-16alpha-hydroxy-24-methylene-5alpha-lanost-8-en-21-oic acid, 1) and 3alpha-(3-hydroxy-5-methoxy-3-methyl-1,5-dioxopentyloxy)-24-methylene-5alpha-lanost-8-en-21-oic acid (2), together with a known compound, 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid (3), were isolated from the fruiting body of Ganoderma resinaceum. The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC(50) value of 2.5 microg/ml in Hep-2 cell line.
Niu
Xue-Mei
XM
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Li
Sheng-Hong
SH
Xiao
Wei-Lie
WL
Sun
Han-Dong
HD
Che
Chun-Tao
CT
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes