Bacterial vaginosis and human immunodeficiency virus infection.
Epidemiologic studies indicate that bacterial vaginosis (BV), a common alteration of lower genital tract flora in women, is associated with increased susceptibility to HIV infection. Other recent studies show that HIV is detected more frequently and at higher levels in the lower genital tract of HIV-seropositive women with BV. In vitro studies show that genital tract secretions from women with BV or flora associated with BV induce HIV expression in infected cells. The increased HIV expression appears to be due at least in part to activation through Toll-like receptors (TLR), specifically TLR2. Further research is needed to elucidate how BV contributes to HIV acquisition and transmission.
Spear
Gregory T
GT
Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612, USA. gspear@rush.edu
St John
Elizabeth
E
Zariffard
M Reza
MR