Ovarian recovery after stem cell transplantation.
Autologous or allogeneic SCT with conventional conditioning (chemotherapy with or without irradiation) has emerged as an effective and potentially curative therapy in patients with hematologic malignancies and in other selected solid tumors; however, several patients experience significant early and delayed side effects, including long-term endocrine imbalance and infertility. In spite of several reproductive recovery and pregnancy reports published in the oncology literature, review of medical literature reveals a paucity of comparable information in the SCT field. We report here four cases of ovarian recovery in patients who received hormonal replacement therapy after diagnosis of primary ovarian failure due to high-dose chemotherapy and SCT.
Liu
J
J
Department of Medicine, Moores University of California San Diego Cancer Center, University of California San Diego, San Diego, CA, USA.
Malhotra
R
R
Voltarelli
J
J
Stracieri
A B
AB
Oliveira
L
L
Simoes
B P
BP
Ball
E D
ED
Carrier
E
E
D000328:Adult; D015914:Estrogen Replacement Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D008598:Menstruation / Q000187:drug effects; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D019172:Transplantation Conditioning / Q000009:adverse effects*; D016896:Treatment Outcome