Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique.
The aim of the work was to improve the dissolution properties of the practically insoluble antiepileptic drug, Carbamazepine (CBZ) by adopting the liquisolid compaction technique. Reported liquid load factors, and excipient ratios were used to calculate the required amounts of excipients necessary to prepare the compacts or tablets according to a mathematical model. Avicel PH 102, and Aerosil 200 were used as the carrier and the coating materials, respectively, and explotab was used as disintegrant to prepare four tablet formulae, out of which formula 1 was successfully compressed into tablets. The dissolution patterns of liquisolid CBZ tablets, carried out according to the USP, were comparable to those of Tegretol. The protection of male albino mice against the convulsion, induced by electroshock, was lower in case of liquisolid tablets compared to Tegretol suspension and tablets probably due to the precipitation of CBZ in the silica pores resulting from its high dose.
Tayel
Saadia A
SA
Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Egypt.
Soliman
Iman I
II
Louis
Dina
D
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage; D002220:Carbamazepine / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D008297:Male; D051379:Mice; D008962:Models, Theoretical; D019946:Propylene Glycol / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013608:Tablets, Enteric-Coated / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D017155:Wettability
D000927:Anticonvulsants; D013607:Tablets; D013608:Tablets, Enteric-Coated; D002220:Carbamazepine; D019946:Propylene Glycol