Cardiac Fabry's disease: an unusual cause of left ventricular hypertrophy.
BACKGROUND
A 64-year-old male was observed as an outpatient with atypical, non-exercise-induced chest pain and palpitations. He had arterial hypertension and marked concentric left ventricular hypertrophy. After 2.5 years of antihypertensive drug therapy the patient's blood pressure had returned to normal, but his left ventricular hypertrophy was unchanged.


METHODS
Electrocardiography, transthoracic echocardiography, myocardial perfusion scintigraphic imaging, measurement of alpha-galactosidase A activity, gene sequencing, brain MRI, carotid artery ultrasonography, biochemical renal evaluation and cardiac Doppler tissue imaging.


METHODS
Cardiac Fabry's disease.


RESULTS
Losartan, hydrochlorothiazide, low-dose aspirin and bisoprolol. The patient is expected to begin enzyme replacement therapy.
Nunes
José Pedro L
JP
Faculdade de Medicina do Porto, Alameda Prof Hernâni Monteiro, 4200 Porto, Portugal. jplnunes@med.up.pt
Costa
Ovídio
O
Faria
Maria do Sameiro
Mdo S
Almeida
Pedro Bernardo
PB
Lacerda
Lúcia
L
D002317:Cardiovascular Agents / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D057487:Enzyme Therapy; D000795:Fabry Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D000519:alpha-Galactosidase / Q000097:blood / Q000627:therapeutic use
D002317:Cardiovascular Agents; D000519:alpha-Galactosidase