title: Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma.
abstract: Three quantitative and non-invasive techniques were used to monitor angiogenesis in Kaposi's sarcoma patients: thermography, laser Doppler imaging (LDI), and near-infrared spectroscopy. Before and after combination cytotoxic and anti-angiogenesis therapy, blood volume, oxygenated hemoglobin, temperature, and blood flow were analyzed. These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy.
authors.affiliation: Laboratory of Integrative & Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. vogelab@mail.nih.gov
authors.forename: Abby
authors.initials: A
authors.lastname: Vogel
authors.forename: Bahar
authors.initials: B
authors.lastname: Dasgeb
authors.forename: Moinuddin
authors.initials: M
authors.lastname: Hassan
authors.forename: Franck
authors.initials: F
authors.lastname: Amyot
authors.forename: Victor
authors.initials: V
authors.lastname: Chernomordik
authors.forename: Yang
authors.initials: Y
authors.lastname: Tao
authors.forename: Stavros G
authors.initials: SG
authors.lastname: Demos
authors.forename: Kathleen
authors.initials: K
authors.lastname: Wyvill
authors.forename: Karen
authors.initials: K
authors.lastname: Aleman
authors.forename: Richard
authors.initials: R
authors.lastname: Little
authors.forename: Robert
authors.initials: R
authors.lastname: Yarchoan
authors.forename: Amir H
authors.initials: AH
authors.lastname: Gandjbakhche
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D015203:Reproducibility of Results; D012514:Sarcoma, Kaposi / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013817:Thermography / Q000379:methods*