title: Metal-on-metal hip implants: do they impair renal function in the long-term? A 10-year follow-up study.
abstract: BACKGROUND
  The aim of our study was to investigate a potential influence of elevated serumcobalt and serumchromiumlevels on renal function at minimum 10 years after implantation of a metal-on-metal hip.
  
  
  METHODS
  Between November 1992 and June 1994 98 patients (44 m, 54 f) with an average age of 56 (22-79) years received a metal-on-metal bearing Metasul. At the time of the 10-year follow-up, 15 patients had died and 8 were lost to follow-up. The remaining 75 patients had laboratory analysis including serumcreatinine and full blood cell count as well as chromium and cobalt serum levels.
  
  
  RESULTS
  Ten years postoperatively the median serumcreatinine level was 0.86 (0.55-1.51) mg/dl, the serumcreatinine clearance Ccr was in the normal range. The hemogram did not differ from that measured at the time of surgery. The median serumcobalt concentration was 0.75 (0.3-50.10) microg/l and the serumchromium concentration was 0.95 (0.3-58.6) mug/l, 10 years postoperatively.
  
  
  CONCLUSIONS
  Our long-term data do not show any influence of serum cobalt or chromium concentrations on renal function following total hip arthroplasty.
authors.affiliation: Department of Orthopaedics, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, Austria. martina.marker@gmx.net
authors.forename: Martina
authors.initials: M
authors.lastname: Marker
authors.forename: Alexander
authors.initials: A
authors.lastname: Grübl
authors.forename: Otto
authors.initials: O
authors.lastname: Riedl
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Erich
authors.initials: E
authors.lastname: Pohanka
authors.forename: Rainer
authors.initials: R
authors.lastname: Kotz
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D003401:Creatine / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007595:Joint Prosthesis; D007668:Kidney / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011300:Preoperative Care; D011474:Prosthesis Design; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D002857:Chromium; D003035:Cobalt; D003401:Creatine