Chondrocyte nuclear response to osmotic loading.
Cartilage compression results in changes in the shape, volume as well as hydrostatic and osmotic pressure of chondrocytes in situ. For example, changes in the cellular osmotic environment have been shown to modulate chondrocyte biosynthesis and gene expression, however, the mechanosensing mechanisms mediating these responses are relatively unknown. Nuclear shape and size changes resulting from cell deformation have been suggested to alter cell functions, and as such we recently performed a study that reported that chondrocytes and their nuclei respond to osmotic loading with alterations in their size. In the current study, we focus on the potential role of the actin cytoskeleton in mediating the transmission of osmotic loading-induced cell size changes to the nucleus.
Oswald
Elizabeth S
ES
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA.
Chao
Pen-hsiu G
PH
Bulinski
J Chloe
JC
Ateshian
Gerard A
GA
Hung
Clark T
CT
D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D048430:Cell Shape; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D015638:Cytochalasin D / Q000494:pharmacology; D006874:Hydrostatic Pressure; D008954:Models, Biological; D009997:Osmotic Pressure; D016474:Weight-Bearing
D015638:Cytochalasin D