title: Tissue inhibitor of metalloproteinase-2 G-418C polymorphism is associated with an increased risk of gastric cancer in a Chinese population.
abstract: OBJECTIVE
  To examine the effect of the TIMP-2 G-418C polymorphism on gastric cancer risk.
  
  
  METHODS
  We conducted a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 412 individuals (206 gastric cancer patients and 206 age, sex matched cancer-free controls).
  
  
  RESULTS
  The genotype and allele frequencies were significantly different (P = 0.007 and 0.005, respectively) between cases and controls. Further analysis showed that the variant TIMP-2 genotypes (CC+GC) had a 51% increased risk of gastric cancer compared with GG [adjusted odds ratio (OR) 1.51, 95% confidence interval (CI) 1.00-2.26, P = 0.049]. The elevated gastric cancer risk was especially evident in younger individuals (age < 58 years old) (adjusted OR 2.21, 95% CI 1.18-4.16) and smokers (adjusted OR 2.61, 95% CI 1.01-6.72). However, no significant association was observed between the variant genotypes and clinicopathological features of gastric cancer.
  
  
  CONCLUSIONS
  These findings suggest that the TIMP-2 G-418C polymorphism is a genetic predisposing factor for gastric cancer.
authors.affiliation: Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: H-J
authors.initials: HJ
authors.lastname: Gu
authors.forename: H-J
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Q-M
authors.initials: QM
authors.lastname: Sun
authors.forename: R-H
authors.initials: RH
authors.lastname: Cong
authors.forename: B
authors.initials: B
authors.lastname: Zhou
authors.forename: N-P
authors.initials: NP
authors.lastname: Tang
authors.forename: B
authors.initials: B
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000235:genetics*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000235:genetics*
chemical_list: D019716:Tissue Inhibitor of Metalloproteinase-2