Morphological changes in endometrium of hemodialyzed women of reproductive age.
OBJECTIVE
The aim of the study was to evaluate endometrial morphology and its correlation with hormonal profile in uremic women of reproductive age undergoing hemodialysis.


METHODS
Sixty-three hemodialyzed women aged 18-45 years were enrolled into the study, 38 of whom gave their informed consent to undergo endometrial aspiration biopsy and measurement of hormonal profile.


RESULTS
Abnormal endometrial morphology was noted in 79% of the hemodialyzed women. Atrophic endometrium was observed in almost all uremic patients with secondary amenorrhea. Endometrial biopsy revealed one case of adenocarcinoma in situ. Analysis of the relationship between hormonal profile and endometrial morphology revealed the substantial influence of estradiol on endometrium.


CONCLUSIONS
Abnormal endometrial changes are often noted in uremic women of reproductive age undergoing hemodialysis. Endometrial biopsy should be carried out as a safe and convenient procedure for the detection of pathological changes in uremic women.
Skórzewska
Katarzyna
K
Department of Gynecological Endocrinology, Medical University Warsaw, Warsaw, Poland. kskorzewska@gmail.com
Radowicki
Stanisław
S
Matuszkiewicz-Rowinska
Joanna
J
Szlendak-Sauer
Katarzyna
K
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis; D012098:Reproduction; D013739:Testosterone / Q000097:blood; D014511:Uremia / Q000097:blood / Q000150:complications* / Q000628:therapy*; D014591:Uterine Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone