Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation.
A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory-element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter.
Roder
K
K
School of Life Sciences, Heriot-Watt University, Edinburgh EH14 4AS, U.K.
Schweizer
M
M
D000818:Animals; D002460:Cell Line; D064429:Fatty Acid Synthases / Q000378:metabolism*; D006801:Humans; D011401:Promoter Regions, Genetic; D051381:Rats; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology*
D051780:Sterol Regulatory Element Binding Protein 1; D014212:Tretinoin; D064429:Fatty Acid Synthases