Propranolol preparations on the Belgian market: a comparative study.
Propranolol preparations formulated as immediate-release tablets and prolonged-release capsules were evaluated with different tests, including in vitro dissolution and assay with previously validated methods according to the guideline of the European network of Official Medicines Control Laboratories (OMCLs). All examined products complied with our requirements and those described in the European, British and the US Pharmacopoeia and consequently they can be considered as pharmaceutically equivalent.
De Braekeleer
K
K
Service de Contrôle des Médicaments - Dienst Geneesmiddelen-onderzoek, rue Stévin, 137, B-1000 Bruxelles.
Fierens
C
C
Corthout
J
J
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D001530:Belgium; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D011433:Propranolol / Q000008:administration & dosage / Q000493:pharmacokinetics; D012015:Reference Standards; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013810:Therapeutic Equivalency
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D011433:Propranolol