title: Synthesis of phosphorothioate oligonucleotide-peptide conjugates by solid phase fragment condensation.
abstract: Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
authors.affiliation: School of Humanity Oriented Science and Technology, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.
authors.forename: Irmina
authors.initials: I
authors.lastname: Diala
authors.forename: Akira
authors.initials: A
authors.lastname: Osada
authors.forename: Shinji
authors.initials: S
authors.lastname: Maruoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Imanisi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murao
authors.forename: Taishi
authors.initials: T
authors.lastname: Ato
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohba
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000595:Amino Acid Sequence; D002412:Cations; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000494:pharmacology; D010446:Peptide Fragments / Q000032:analysis / Q000138:chemical synthesis*; D054735:Phosphorothioate Oligonucleotides / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D019098:Telomerase / Q000037:antagonists & inhibitors
chemical_list: D002412:Cations; D016376:Oligonucleotides, Antisense; D010446:Peptide Fragments; D054735:Phosphorothioate Oligonucleotides; D019098:Telomerase