Ubiquitin-proteasome: pallbearer carries the deceased to the grave.
Phagocytosis is a complex process that involves multiple cellular functions. In this issue of Immunity, Silva et al. (2007) report that a protein ubiquitylation complex and the proteasome are required for the clearance of apoptotic cells in Drosophila.
Ferrandon
Dominique
D
IBMC du CNRS, 15 rue Descartes, 67084 Strasbourg Cedex, France. d.ferrandon@ibmc.u-strasbg.fr
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D010587:Phagocytosis / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex