The EDEM and Yos9p families of lectin-like ERAD factors.
Protein quality control pathways monitor the folding of newly synthesized proteins throughout the cell. Irreversibly misfolded proteins are sorted and degraded to neutralize their potential toxicity. In the secretory pathway, multiple strategies have evolved to test the wide diversity of molecules that traffic through the endoplasmic reticulum. The organelle has adapted the use of N-linked glycans to signal protein folding states. The signals are read by the EDEM and Yos9 protein families that take substrates out of folding cycles for degradation.
Kanehara
Kazue
K
Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604, Singapore.
Kawaguchi
Shinichi
S
Ng
Davis T W
DT
D000818:Animals; D002352:Carrier Proteins; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins; D011134:Polysaccharides; D017510:Protein Folding; D021381:Protein Transport; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction; D015003:Yeasts
D002352:Carrier Proteins; C486654:EDEM1 protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011134:Polysaccharides; D029701:Saccharomyces cerevisiae Proteins; C495027:Yos9 protein, S cerevisiae