title: An intelligent data collection tool for chemical safety/risk assessment.
abstract: REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is the new European chemical legislation which aims to assess risk or safety of tens of thousands of chemicals to improve the protection of human health and the environment. The chemical safety assessment process is of an iterative nature. First, an initial, worst-case assessment is conducted after which refinements are made until no risk has been estimated or the risk is adequately controlled. Wasting time and resources on additional testing and implementing risk management measures with low effect on risk conclusions should be avoided as much as possible. This paper demonstrates the usefulness of an intelligent data collection strategy based on a sensitivity (and uncertainty) analysis on the risk assessment model EUSES to identify and order the most important "within-EU-TGD-reducible" input parameters influencing the local and regional risk characterisation ratios. The ordering can be adjusted for the costs involved in additional testing (e.g. ecotoxicity, physico-chemical properties, emission estimates, etc.). The risk refinement tool therefore reduces the resources needed to obtain a realistic risk estimate (both less conservative and less uncertain) as efficient as possible.
authors.affiliation: BIOMATH, Department of Applied Mathematics, Biometrics and Process Control, Ghent University, Gent, Belgium. frederick.verdonck@euras.be
authors.forename: Frederik A M
authors.initials: FA
authors.lastname: Verdonck
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Van Sprang
authors.forename: Peter A
authors.initials: PA
authors.lastname: Vanrolleghem
mesh_terms: D003625:Data Collection / Q000379:methods*; D015386:Hazardous Substances / Q000633:toxicity*; D018570:Risk Assessment; D035501:Uncertainty
chemical_list: D015386:Hazardous Substances