title: Evaluation of pacemaker dependence in patients on ablate and pace therapy for atrial fibrillation.
abstract: OBJECTIVE
  In patients with atrial fibrillation (AF) and uncontrolled ventricular rate, radiofrequency (RF) ablation of the atrioventricular (AV) node and pacemaker (PM) implantation (ablate and pace) is a valid therapeutic approach, especially in elderly patients. The aim of our study was to evaluate the PM dependence and the incidence of correlated clinical phenomena in a patients population with AV block induced by RF ablation of the AV junction.
  
  
  RESULTS
  One-hundred and sixty-three patients (71 men; mean age 71 +/- 8 years) who had undergone ablate and pace therapy were evaluated. The patients underwent assessment of quality of life, impairment of consciousness, stroke/transient ischaemic attack (TIA), hospitalizations for heart failure, episodes of palpitations, and instrumental evaluation of PM dependence during PM inhibition (absence of escape rhythm; asystolic pause >5 s; escape rhythm <30 bpm after rhythm stabilization). Correlation between instrumentally evaluated PM dependence and clinical history was analysed. Hundred and thirty-two patients were evaluated after a mean follow-up period of 36 months [31 subjects (19%) died before the evaluation]; 55 patients (42%) were classified as PM-dependent: 38 (69%) complained of disturbances (19 dizziness, 15 pre-syncope, 4 syncope); 77 patients (58%) were considered non-PM-dependent: symptoms (dizziness, flush) were reported by only 3 (4%). No significant differences emerged between PM-dependent and non-PM-dependent patients with regard to episodes of pre-syncope, syncope, stroke/TIA, hospitalizations for heart failure, and quality of life.
  
  
  CONCLUSIONS
  This study confirms that ablate and pace is an effective and safe approach in subjects with chronic or recurrent AF and uncontrolled ventricular rate.
authors.affiliation: Cardiology Division, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy. occhetta@r-j.it
authors.forename: Eraldo
authors.initials: E
authors.lastname: Occhetta
authors.forename: Miriam
authors.initials: M
authors.lastname: Bortnik
authors.forename: Gabriele
authors.initials: G
authors.lastname: Dell'era
authors.forename: Fabio
authors.initials: F
authors.lastname: Zardo
authors.forename: Ermanno
authors.initials: E
authors.lastname: Dametto
authors.forename: Biagio
authors.initials: B
authors.lastname: Sassone
authors.forename: Luca
authors.initials: L
authors.lastname: Gabrieli
authors.forename: Paolo
authors.initials: P
authors.lastname: Marino
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D001283:Atrioventricular Node / Q000601:surgery*; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects; D017115:Catheter Ablation / Q000009:adverse effects; D003131:Combined Modality Therapy; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000517:prevention & control; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial / Q000009:adverse effects; D011788:Quality of Life; D013575:Syncope / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome