title: Juvenile hormone activity in Dysdercus cingulatus Fabr by juvenile hormone esterase inhibitor, OTFP.
abstract: Application of juvenile hormone esterase inhibitor 3-octylthio-1,1,1- trifluropropan-2-one (OTFP) to 5th instar nymphs and virgin females of D. cingulatus revealed the profound role played by juvenile hormone esterase (JHE) in metamorphosis and reproduction. The ability of OTFP to cause delay and the formation of malformed nymphs, suggests that inhibition of JHE in vivo maintains a higher than normal hemolymph JH titer. It is obvious that OTFP does inhibit in vivo JHE activity in late instar nymphs. Further, the application of JHE inhibitor, OTFP to virgin females demonstrates that substituted trifluropropanones can indirectly stimulate egg development by inhibiting JHE activity in virgin females.
authors.affiliation: Department of Zoology, University of Kerala, Kariavattom 695 581, Kerala, India.
authors.forename: U Gayathri
authors.initials: UG
authors.lastname: Elayidam
authors.forename: D
authors.initials: D
authors.lastname: Muraleedharan
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007313:Insecta / Q000187:drug effects* / Q000378:metabolism*; D007605:Juvenile Hormones / Q000378:metabolism*; D009758:Nymph / Q000187:drug effects / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D007605:Juvenile Hormones; D000096:Acetone; C055697:3-octylthio-1,1,1-trifluoro-2-propanone; D002265:Carboxylic Ester Hydrolases; C038003:juvenile hormone esterase