Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition.
Antidepressants facilitate neuroplasticity by stimulating trophic factors. This study evaluated the effect of fluoxetine (FLX) treatment on insulin-like growth factor-1 (IGF-1) in the rat brain and its role in the effect of FLX on cognition. IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats. Rats were subjected to the Morris Water Maze test. Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC. Repeated FLX increased both mRNA and IGF-1R levels in the FC. Repeated, but not acute, FLX treatment decreased IGF-1 mRNA in the hippocampus. FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system.
Grunbaum-Novak
Nurit
N
Lab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel-Aviv University, Petach Tikva, Israel.
Taler
Michal
M
Gil-Ad
Irit
I
Weizman
Abraham
A
Cohen
Hagit
H
Weizman
Ronit
R
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004334:Drug Administration Schedule; D005473:Fluoxetine / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism*
D000928:Antidepressive Agents; D012333:RNA, Messenger; D005473:Fluoxetine; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1