title: Prevention of diabetes development in those with the metabolic syndrome.
abstract: Metabolic syndrome is characterized by abnormal glucose levels, central obesity, hypertension, elevated triglycerides, and low HDL cholesterol. This article reviews available data regarding the impact of lifestyle modification and drug therapies on the progression to diabetes in high risk individuals, such as those with hypertension, dyslipidemia, obesity, and prediabetes. Lifestyle and pharmacological interventions may alter metabolic parameters and impact progression to diabetes. However, the cost-effectiveness of these interventions are unclear.
authors.affiliation: Warren Alpert Medical School of Brown University, 1 Hoppin Street, Suite 200, Providence, RI 02860, USA.
authors.forename: Traci
authors.initials: T
authors.lastname: Tupper
authors.forename: Geetha
authors.initials: G
authors.lastname: Gopalakrishnan
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000150:complications*; D011379:Prognosis; D015431:Weight Loss
chemical_list: D019440:Anti-Obesity Agents