Clustering and colocalization in transmission immunoelectron microscopy: a brief review.
This mini-review tries to summarize the state of the art of stereological and statistical approaches used in clustering (in single immunogold labelling) and colocalization (in double immunogold labelling) studies of gold particles in transmission immunoelectron microscopy. The point pattern analysis may be useful to compare experimental pattern data to the null hypothesis of complete spatial randomness (CSR), and, furthermore to quantify the amount of clustering and/or colocalization. In particular, this paper gives an overview about the most recent literature on the subject and different approaches will be only briefly summarized.
D'Amico
Fabio
F
Department of Biomedical Sciences, University of Catania, via Androne 83, I-95124 Catania, Italy. f.damico@unict.it
Skarmoutsou
Evangelia
E
D007091:Image Processing, Computer-Assisted / Q000379:methods; D007150:Immunohistochemistry / Q000379:methods*; D016253:Microscopy, Immunoelectron / Q000379:methods*