title: Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification.
abstract: The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Bao
authors.forename: Weige
authors.initials: W
authors.lastname: Zhang
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Zhang
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Qu
authors.forename: Liang
authors.initials: L
authors.lastname: Tian
authors.forename: Lan
authors.initials: L
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
mesh_terms: D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004951:Esterification; D008872:Microwaves
chemical_list: D004917:Erythromycin