Anti-tuberculosis drug resistance among new and previously treated pulmonary tuberculosis patients in Cotonou, Benin.
OBJECTIVE
To assess the current anti-tuberculosis drug resistance situation in Cotonou, at the largest anti-tuberculosis centre of Benin.


METHODS
A total of 470 isolates of Mycobacterium tuberculosis complex from pulmonary tuberculosis (TB) patients were analysed: 244 from new cases and 226 from previously treated cases. Drug susceptibility testing of isolates against first-line drugs was performed using the proportion method.


RESULTS
Primary multidrug resistance (MDR) depends on the patients' origin: MDR in new cases is relatively high (1.6%) when all patients are considered, but low (0.5%) and comparable to 1994 national survey results when only patients residing in Benin are considered. MDR in previously treated patients (11.1%) remains comparable to the study performed in Benin in 1994. No relation was found between human immunodeficiency virus co-infection and anti-tuberculosis drug resistance.


CONCLUSIONS
This study shows the great importance of correct patient identification in epidemiological surveys, where results may vary according to the population(s) studied.
Affolabi
D
D
Programme National Contre la Tuberculose, Cotonou, Benin.
Adjagba
O A B G
OA
Tanimomo-Kledjo
B
B
Gninafon
M
M
Anagonou
S Y
SY
Portaels
F
F
D000995:Antitubercular Agents / Q000494:pharmacology*; D001541:Benin; D015658:HIV Infections / Q000150:complications; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*
D000995:Antitubercular Agents