Effect of L-type calcium channel blockers on activity of newly formed synapses in mice.
Verapamil (5 microM), nifedipine (10 microM), and ryanodine (10 microM) potentiated rhythmic activity of newly formed synapses, while apamin produced no effect on this potentiation. Ryanodine (1 microM) suppressed synaptic activity, and this effect can be prevented with nifedipine. It was hypothesized that in newly formed synapses Ca2+ entry through L-type channels triggers the release of stored Ca2+, which inhibits secretion of the neurotransmitter.
Balezina
O P
OP
M. V. Lomonosov Moscow State University. balezina@mail.ru
Bogacheva
P O
PO
Orlova
T Yu
TY
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D020746:Calcium Channels, L-Type / Q000502:physiology*; D004594:Electrophysiology; D051379:Mice; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D012433:Ryanodine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D012433:Ryanodine; D014700:Verapamil; D009543:Nifedipine