[ACE-inhibitor induced angioedema].
ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.
Bas
M
M
Hals-Nasen-Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany. basmurat@web.de
Hoffmann
T K
TK
Kojda
G
G
Bier
H
H
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000465:Algorithms; D000799:Angioedema / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy; D054179:Angioedemas, Hereditary / Q000175:diagnosis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D001920:Bradykinin / Q000031:analogs & derivatives / Q000097:blood / Q000502:physiology / Q000627:therapeutic use; D065168:Bradykinin Receptor Antagonists; D005544:Forecasting; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007819:Laryngeal Edema / Q000139:chemically induced* / Q000175:diagnosis; D007828:Laryngoscopy; D008279:Magnetic Resonance Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000305:Adrenal Cortex Hormones; D000806:Angiotensin-Converting Enzyme Inhibitors; D065168:Bradykinin Receptor Antagonists; D006633:Histamine Antagonists; C065679:icatibant; D001920:Bradykinin