title: Colistin heteroresistance in acinetobacter and its association with previous colistin therapy.
abstract: Colistin heteroresistance has been reported among Acinetobacter isolates; however, its association with prior colistin therapy has not been not described. A population analysis profile identified resistant Acinetobacter subpopulations from colistin-susceptible clinical isolates. The proportion of cells exhibiting heteroresistance was significantly higher among isolates recovered from patients treated with colistin.
authors.affiliation: Department of Medicine, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Hawley
authors.forename: Clinton K
authors.initials: CK
authors.lastname: Murray
authors.forename: James H
authors.initials: JH
authors.lastname: Jorgensen
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D016954:Acinetobacter calcoaceticus / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin