title: An emergency medicine approach to neonatal hyperbilirubinemia.
abstract: Jaundice (also known as hyperbilirubinemia) is a yellowish-greenish pigmentation of the sclera and skin caused by an increase in bilirubin production or a defect in bilirubin elimination. Management of hyperbilirubinemia is one of the most common reasons for readmission of a newborn. Prolonged unconjugated hyperbilirubinemia can result in acute bilirubin encephalopathy and eventually develop into chronic bilirubin encephalopathy (kernicterus). Kernicterus, the feared complication of hyperbilirubinemia, was considered almost extinct but has recently re-emerged despite virtual elimination of Rh disease. This review provides a systematic approach to the presentation, evaluation, and management of the jaundiced newborn.
authors.affiliation: Department of Emergency Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. jamesecolletti@gmail.com
authors.forename: James E
authors.initials: JE
authors.lastname: Colletti
authors.forename: Samip
authors.initials: S
authors.lastname: Kothari
authors.forename: Samip
authors.initials: S
authors.lastname: Kothori
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Jackson
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Kilgore
authors.forename: Kelly
authors.initials: K
authors.lastname: Barringer
mesh_terms: D000367:Age Factors; D001663:Bilirubin / Q000097:blood / Q000378:metabolism; D004636:Emergency Service, Hospital; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D010789:Phototherapy; D012306:Risk
chemical_list: D001663:Bilirubin