title: Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats.
abstract: OBJECTIVE
  Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated.
  
  
  METHODS
  Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated.
  
  
  RESULTS
  Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH.
  
  
  CONCLUSIONS
  Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.
authors.forename: Jin-Moo
authors.initials: JM
authors.lastname: Lee
authors.forename: Guihua
authors.initials: G
authors.lastname: Zhai
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Liu
authors.forename: Ernesto R
authors.initials: ER
authors.lastname: Gonzales
authors.forename: Kejie
authors.initials: K
authors.lastname: Yin
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
authors.forename: Chung Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: Katie D
authors.initials: KD
authors.lastname: Vo
authors.forename: Weili
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000473:pathology; D006973:Hypertension; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010539:Permeability; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020521:Stroke / Q000473:pathology*; D013997:Time Factors