A handy and solventless direct route to primary 3-[3-aryl)-1,2,4-oxadiazol-5-yl]propionamides using microwave irradiation.
A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described.
Neves Filho
Ricardo A W
RA
Departamento de Química Fundamental, Universidade Federal de Pernambuco, 50.740-540 Recife, PE, Brazil.
Srivastava
Rajendra M
RM
D000577:Amides / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000737:chemistry; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D011422:Propionates / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000577:Amides; D002264:Carboxylic Acids; D011422:Propionates; C029658:propionic acid