title: Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss.
abstract: Unlike epidemics in past centuries, patients suffering from peripheral vascular ischemia related to ergotism now rarely lose a limb because of vasodilator therapies. We report a patient with ischemia from ergotamine tartrate who failed to recover with medical therapy, resulting in limb amputation.
authors.affiliation: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. kmusikatavorn@yahoo.com
authors.forename: Khrongwong
authors.initials: K
authors.lastname: Musikatavorn
authors.forename: Suchai
authors.initials: S
authors.lastname: Suteparuk
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D003131:Combined Modality Therapy; D004878:Ergotamine / Q000009:adverse effects* / Q000627:therapeutic use; D004881:Ergotism / Q000188:drug therapy* / Q000209:etiology; D005528:Foot / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D005734:Gangrene / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007275:Injections, Intravenous; D007511:Ischemia / Q000139:chemically induced / Q000175:diagnosis; D007866:Leg; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000517:prevention & control; D017211:Treatment Failure; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D009599:Nitroprusside; D004878:Ergotamine