title: Streptomyces coelicolor undergoes spontaneous chromosomal end replacement.
abstract: We report a previously unobserved form of genetic instability for Streptomyces coelicolor, the replacement of one chromosome end by the other end. These genetic changes occurred spontaneously in both a wild-type strain and strains harboring a foreign transposon. Deleted and duplicated DNA comprises up to 33% of the genome.
authors.affiliation: Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA. ewidenbrant@gmail.com
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Widenbrant
authors.forename: Hsiu-Hui
authors.initials: HH
authors.lastname: Tsai
authors.forename: Carton W
authors.initials: CW
authors.lastname: Chen
authors.forename: Camilla M
authors.initials: CM
authors.lastname: Kao
mesh_terms: D002876:Chromosomes, Bacterial / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D011995:Recombination, Genetic; D048372:Streptomyces coelicolor / Q000235:genetics*
chemical_list: D004269:DNA, Bacterial