Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease.
OBJECTIVE
To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT).


METHODS
One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review.


RESULTS
Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients (p < 0.0013, p < 0.00015, p < 0.0008, respectively).


CONCLUSIONS
SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.
Kamoi
Mizuka
M
Department of Ophthalmology, Keio University, School of Medicine, Tokyo, Japan.
Ogawa
Yoko
Y
Dogru
Murat
M
Uchino
Miki
M
Kawashima
Motoko
M
Goto
Eiki
E
Mori
Takehiko
T
Okamoto
Shinichiro
S
Shimazaki
Jun
J
Tsubota
Kazuo
K
D000328:Adult; D002908:Chronic Disease; D002921:Cicatrix / Q000473:pathology; D015352:Dry Eye Syndromes / Q000209:etiology / Q000503:physiopathology; D005128:Eye Diseases / Q000150:complications*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000503:physiopathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000209:etiology* / Q000473:pathology; D008297:Male; D008537:Meibomian Glands / Q000503:physiopathology; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index