Effect of thin carbonate-containing apatite (CA) coating of titanium fiber mesh on trabecular bone response.
The influence of thin carbonate-containing apatite (CA) coating on trabecular bone response to cylindrical titanium fiber mesh (porosity of 85%, pore size of 200-300 microm, 2.8 mm diameter x 6 mm length) implants was investigated. Thin CA coatings were deposited by the so-called molecular precursor method. Molecular precursor solution was obtained by adding dibutylammonium diphosphate salt to Ca-EDTA/amine ethanol solution by adjusting Ca/P = 1.67. Sintered cylindrical titanium fiber mesh was immersed into molecular precursor solution and then tempered at 600 degrees C for 2 h. The immersion and tempering process was repeated three times. An adherent thin CA film could be deposited on the inside of titanium fiber mesh. After the immersion of a CA-coated titanium fiber mesh in simulated body fluid, apatite crystals precipitated on the titanium fiber mesh. Uncoated and CA-coated titanium fiber mesh was inserted into the trabecular bone of the left and right femoral condyles of rabbits. Histological and histomorphometrical evaluation revealed a significantly greater amount of bone formation inside the porous area of the CA-coated titanium fiber mesh after 12 weeks of implantation. The present results suggested that a thin CA-coated titanium mesh has better osteoconductivity and will be useful for a three-dimensional scaffold.
Hayakawa
Tohru
T
Department of Dental Biomaterials, Nihon University School of Dentistry, 2-870-1, Sakaecho-nishi, Matsudo, Chiba 271-8587, Japan. hayakawa.tohru@nihon-u.ac.jp
Takahashi
Kenichi
K
Okada
Hiroyuki
H
Yoshinari
Masao
M
Hara
Hiroki
H
Mochizuki
Chihiro
C
Yamamoto
Hirotsugu
H
Sato
Mitsunobu
M
D000588:Amines / Q000737:chemistry; D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism; D020099:Coated Materials, Biocompatible; D004492:Edetic Acid / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D000588:Amines; D001031:Apatites; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; C101914:titanium fiber; D000431:Ethanol; C030782:carboapatite; D004492:Edetic Acid; D014025:Titanium