[Adaptive cell immune response against the hepatitis C virus infection].
Hepatitis C virus (HCV) infects around 175 million people worldwide and is one of the leading causes of chronic liver disease. Less than one third of patients infected with HCV are able to spontaneously clear the virus during acute infection, while most patients evolve to chronic infection. Control of viral replication has been associated to the cellular component of the host immune response. It is not fully understood what distinguish a successful cellular immune response. An integral interpretation of the numerous experimental findings may allow a better understanding of the immune mechanisms involved in the inability of the immune system to successfully control chronic HCV infection.
Rallón
Norma Ibón
NI
Laboratorio de Biología Molecular, Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, España.
Soriano
Vicente
V
Benito
José Miguel
JM
D000208:Acute Disease; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured / Q000276:immunology; D004195:Disease Models, Animal; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D006526:Hepatitis C / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D016898:Interferon-alpha / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000276:immunology; D009154:Mutation; D002679:Pan troglodytes; D012254:Ribavirin / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013997:Time Factors; D014779:Virus Replication
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin