title: Reconstruction of spatially resolved pharmacokinetic rate images of fluorescence agents in FDOT.
abstract: In this work, we propose a method to reconstruct spatially resolved pharmacokinetic rate images of fluorescence agents directly from the boundary photon flux measurements. We use a compartmental modeling scheme to model the pharmacokinetics of fluorescence agents. We coupled this model with the fluorescence diffuse optical tomography (FDOT) forward model to form a state space model which is then iteratively solved by extended Kalman filtering (EKF) algorithm. As an example, we used a two-compartment model for indocyanine green (ICG) pharmacokinetics. To validate the proposed method, we tested our approach using a simulation study. Reconstructed pharmacokinetic rate images with correct localization of heterogeneities and high reconstruction accuracy show that the proposed algorithm can be used for tumor detection, tumor diagnosis, drug delivery and feasibility studies.
authors.affiliation: Dept. of Electrical Computer & Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 19102, USA.
authors.forename: Burak
authors.initials: B
authors.lastname: Alacam
authors.forename: Birsen
authors.initials: B
authors.lastname: Yazici
authors.forename: Ahmed
authors.initials: A
authors.lastname: Serdaroglu
authors.forename: Xavier
authors.initials: X
authors.lastname: Intes
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
authors.forename: Shoko
authors.initials: S
authors.lastname: Nioka
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional; D015233:Models, Statistical; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D016011:Normal Distribution; D019047:Phantoms, Imaging; D013997:Time Factors; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes