title: Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis.
abstract: To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
authors.affiliation: Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Scagnolari
authors.forename: Fabio
authors.initials: F
authors.lastname: Midulla
authors.forename: Simona
authors.initials: S
authors.lastname: Trombetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pierangeli
authors.forename: Valeria
authors.initials: V
authors.lastname: Tromba
authors.forename: Rosanna
authors.initials: R
authors.lastname: Grossi
authors.forename: Paola
authors.initials: P
authors.lastname: Di Marco
authors.forename: Caterina
authors.initials: C
authors.lastname: Dianzani
authors.forename: Enrico
authors.initials: E
authors.lastname: Girardi
authors.forename: Guido
authors.initials: G
authors.lastname: Antonelli
mesh_terms: D001988:Bronchiolitis / Q000235:genetics* / Q000503:physiopathology / Q000821:virology; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007223:Infant; D007372:Interferons / Q000494:pharmacology*; D010101:Oxygen Consumption; D016133:Polymerase Chain Reaction; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012229:Rhinovirus / Q000302:isolation & purification
chemical_list: D016207:Cytokines; D007372:Interferons