Intracellular NO concentration and its changes in carcinoma cells and cultured human endotheliocytes under the influence of inhibitors and inductors of nitric oxide synthases.
We carried out cytophotometric evaluation of NO content in cells expressing various types of NO synthases. Endogenous production of NO can be modified by NO synthase inductors and inhibitors.
Gil'yano
N Ya
NY
B. P. Konstantinov Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina. giliano@omrb.pnpi.spb.ru
Stepanov
S I
SI
Konevega
L V
LV
Noskin
L A
LA
D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007424:Intracellular Fluid / Q000187:drug effects / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D013936:Thymidine / Q000494:pharmacology
D004791:Enzyme Inhibitors; D006146:Guanidines; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; C004479:pimagedine; D019331:NG-Nitroarginine Methyl Ester; D013936:Thymidine