title: [A follow-up study about 52 cases of atypical lobular hyperplasia and lobular carcinoma in situ of the breast].
abstract: OBJECTIVE
  To evaluate the biological behavior and treatment method for the breast atypical lobular hyperplasia (ALH) and breast lobular carcinoma in situ (LCIS).
  
  
  METHODS
  Seventeen cases of ALH and thirty-five cases of LCIS were reviewed from July 1982 to January 1996. All cases were followed by physical examination, mammography and B-ultrasound for an average of 146.6 months (range, 3 - 257 months).
  
  
  RESULTS
  Most cases of ALH and LCIS occurred before menopause (about 69.2%). Fifty-two cases of ALH and LCIS were occasionally verified pathologically after surgery for benign diseases. The microcalcification with ALH and LCIS had been detected in 25 cases, accounted for 48.1%. Eight cases of ALH/LCIS became invasive carcinoma. There were 5 cases in the same breast, 3 cases in the contralateral breast; The subsequent breast cancer occurred longer than nine years after ALH/LCIS was diagnosed. The family history of breast carcinoma and ovary carcinoma occurred in 4 cases of breast carcinoma, accounted for 50%, but it was no significant (P > 0.05). Also, there was no difference between LCIS and ALH, which occurred the breast carcinoma (P > 0.05).
  
  
  CONCLUSIONS
  The excisional biopsy might be necessary to ALH and LCIS.
authors.affiliation: Department of General Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Li
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Ren
authors.forename: Nasrin
authors.initials: N
authors.lastname: Arnould
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Brettes
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors