title: [Myocardial perfusion abnormality induced by right ventricular pacing: real-time myocardial contrast echocardiography study].
abstract: OBJECTIVE
  False positive findings of coronary stenosis are frequently detected by exercise stress myocardial scintigraphy in patients with left bundle branch block (LBBB). We investigated the relationship between regional wall motion abnormality and myocardial perfusion abnormality at high right ventricular (RV) pacing rate in the region of the RV pacing (the ventricular septum) and the control region (the lateral wall) assuming exercise stress in patients with LBBB.
  
  
  METHODS
  RV pacing was performed in 7 open chest canines. Real time myocardial contrast echocardiography of the left right ventricular short-axis view was examined by Toshiba Aplio during infusion of the ultrasound contrast agent (Definity). The examination was performed at baseline without pacing and at high RV pacing. Replenishment curve of the myocardial opacification was obtained and fit to the equation of y = A (1 - e (-betat)) in the regions of the ventricular septum and the lateral wall. Wall thickening ratio (%WT) was calculated in both regions.
  
  
  RESULTS
  Dyssynchronous motion was observed during high RV pacing, but no wall motion abnormality was seen in control conditions. Although %WT, A-value and beta-value were almost identical between both regions at baseline, %WT and beta decreased in the ventricular septum at high RV pacing. The value did not differ between two regions.
  
  
  CONCLUSIONS
  We concluded that perfusion abnormality occurs with regional wall motion abnormality at high RV pacing based on real time myocardial contrast echocardiography.
authors.affiliation: Department of Functional Diagnostic Science, Graduate School of Medicine, Osaka University, Osaka.
authors.forename: Asuka
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Kasumi
authors.initials: K
authors.lastname: Masuda
authors.forename: Ayumi
authors.initials: A
authors.lastname: Uranishi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Asanuma
authors.forename: Fuminobu
authors.initials: F
authors.lastname: Ishikura
authors.forename: Shintaro
authors.initials: S
authors.lastname: Beppu
mesh_terms: D000818:Animals; D002037:Bundle-Branch Block / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D003326:Coronary Circulation / Q000502:physiology*; D023921:Coronary Stenosis / Q000503:physiopathology; D004285:Dogs; D004452:Echocardiography; D025401:Echocardiography, Stress; D006352:Heart Ventricles / Q000503:physiopathology