Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing.
The bioactive lysophospholipids, primarily lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are recent additions to the list of potent mediators of tissue repair and wound healing. In this review, we highlight the diverse actions of LPA and S1P on many types of cells involved in the wound healing process, with special emphasis on their regulation of fibroblasts. The effects of LPA and S1P are principally mediated via specific cell surface receptors. Important signaling pathways downstream of these receptors and the importance of TGFbeta and S1P cross-talk for wound healing are also discussed. Moreover, specific agonists and antagonists of the lysophospholipid receptors may be useful for the treatment of wounds and abnormal wound healing.
Watterson
Kenneth R
KR
Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.
Lanning
David A
DA
Diegelmann
Robert F
RF
Spiegel
Sarah
S
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D010766:Phosphorylation; D020239:Receptor Cross-Talk / Q000502:physiology; D049349:Receptors, Lysosphingolipid / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; D016212:Transforming Growth Factor beta; C060506:sphingosine 1-phosphate; D013110:Sphingosine; C032881:lysophosphatidic acid