Two new metabolites with cytotoxicities from deep-sea fungus, Aspergillus sydowi YH11-2.
Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3- dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.
Li
De-Hai
DH
Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P. R. China.
Cai
Sheng-Xin
SX
Tian
Li
L
Lin
Zhen-Jian
ZJ
Zhu
Tian-Jiao
TJ
Fang
Yu-Chun
YC
Liu
Pei-Pei
PP
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012623:Seawater / Q000382:microbiology*
D000970:Antineoplastic Agents