Two step synthesis of a non-symmetric acetylcholinesterase reactivator.
The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Musilek
Kamil
K
Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Kuca
Kamil
K
Dohnal
Vlastimil
V
Jun
Daniel
D
Marek
Jan
J
Koleckar
Vit
V
D002801:Cholinesterase Reactivators / Q000138:chemical synthesis*; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis*; D011726:Pyridinium Compounds / Q000138:chemical synthesis*
C508944:(E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide; D002801:Cholinesterase Reactivators; D006842:Hydrocarbons, Brominated; D011726:Pyridinium Compounds