title: Noninvasive multidetector computed tomography enterography in patients with small-bowel Crohn's disease: is a 40-second delay better than 70 seconds?
abstract: BACKGROUND
  Multidetector computed tomography (MDCT) enterography combines neutral enteric contrast with intravenously administered contrast material. The optimal intravenous (IV) contrast material protocol has still not been established.
  
  
  OBJECTIVE
  To determine the optimal delay time to image patients with small-bowel Crohn's disease during MDCT enterography.
  
  
  METHODS
  After oral administration of 1350 ml of neutral contrast medium, 26 patients with small-bowel Crohn's disease underwent MDCT enterography;scans were obtained 40 s (enteric phase) and 70 s (parenchymal phase) after IV administration of 100 ml of iodinated contrast material. Three radiologists, blinded to clinical and pathological findings, independently and retrospectively evaluated each scan in two separate reading sessions for the presence or absence of CT features of Crohn's disease activity. The interobserver agreement was evaluated, and the efficacy of each phase in detecting active disease in the terminal ileum for each reader was determined. The gold standard was pathology (n=13), endoscopy (n=3), and clinical evaluation (n=10).
  
  
  RESULTS
  No statistically significant difference was present between the enteric and the parenchymal phase for each reader in each segment regarding the presence or absence of CT features of Crohn's disease. The interobserver agreement for the presence of five main features of active Crohn's disease in the terminal ileum ranged from poor to excellent.The sensitivity, specificity, negative predictive value, positive predictive value, and accuracy for active Crohn's disease in the terminal ileum ranged from 40 to 90%, 88 to 100%, 70 to 94%, 44 to 100%, and 69 to 96%, respectively. There was no statistical difference between the two phases for each reader.
  
  
  CONCLUSIONS
  MDCT enterography in patients with suspected active Crohn's disease can be obtained at either 40 s or 70 s after IV contrast material.
authors.affiliation: Division of Abdominal, Thoracic Imaging and Intervention, Department of Radiology, UZBrussel, Vrije Universiteit Brussel Laarbeeklaan, Brussels, Belgium. spovef@uzbrussel.be
authors.forename: F
authors.initials: F
authors.lastname: Vandenbroucke
authors.forename: K J
authors.initials: KJ
authors.lastname: Mortelé
authors.forename: S
authors.initials: S
authors.lastname: Tatli
authors.forename: V
authors.initials: V
authors.lastname: Pelsser
authors.forename: S M
authors.initials: SM
authors.lastname: Erturk
authors.forename: J
authors.initials: J
authors.lastname: De Mey
authors.forename: S G
authors.initials: SG
authors.lastname: Silverman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media