Anti-HIV-1 activity of poly(mandelic acid) derivatives.
Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMDA.
Ward
Marty
M
Department of Polymer Science, 118 College Drive #10076, The University of Southern Mississippi, Hattiesburg, MS 39406-10076, USA.
Yu
Bing
B
Wyatt
Victor
V
Griffith
Jelani
J
Craft
Tara
T
Neurath
A Robert
AR
Strick
Nathan
N
Li
Yun-Yao
YY
Wertz
David L
DL
Pojman
John A
JA
Lowe
Andrew B
AB
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D008333:Mandelic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011485:Protein Binding; D012995:Solubility; D013057:Spectrum Analysis; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D008333:Mandelic Acids; D014867:Water