title: [Genome sequencing and analysis of foot-and-mouth disease virus Asia1/YNBS/58 strain].
abstract: The full-length genomic sequence of foot-and-mouth disease virus (FMDV) Asia1/YNBS/58 strain was determined by RT-PCR and compared with other 17 reference strains. The results showed that the complete genome of Asia1/YNBS/58 was 8164nt long including a 1061-nt 5' untranslated region (UTR), a 6990-nt open reading frame (ORF), and a 113-nt 3'UTR. The homology analysis indicated that the UTR regions and non-structural proteins were more conserved than the structural proteins in FMDV. VP1 exhibited the lowest conservation and VP4 was exceptionally conserved. The VP1-, VP2-, and VP3-based phylogenetic trees were divided into distinct clusters according to different serotypes, while the other gene-based phylogenetic trees exhibited some degree of intercross among serotypes. This study is the first description of the full-length genomic sequence of FMDV Chinese serotype Asia1.
authors.affiliation: Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. changhuiyun@126.com
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Chang
authors.forename: Jun-Zheng
authors.initials: JZ
authors.lastname: Du
authors.forename: Guo-Zheng
authors.initials: GZ
authors.lastname: Cong
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Shao
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
authors.forename: Qing-Ge
authors.initials: QG
authors.lastname: Xie
mesh_terms: D020413:3' Untranslated Regions / Q000737:chemistry; D036022:Capsid Proteins / Q000235:genetics; D029544:Foot-and-Mouth Disease Virus / Q000235:genetics*; D016679:Genome, Viral; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D020413:3' Untranslated Regions; D036022:Capsid Proteins; C442501:VP1 protein, Foot-and-mouth disease virus; C442459:VP2 protein, Foot-and-mouth disease virus; C442460:VP3 protein, Foot-and-mouth disease virus