Hetisine-type diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum.
Investigation of Aconitum orochryseum, a Bhutanese traditional medicine ("gSo-ba Rig-pa") plant locally known as "Bong-kar", resulted in the isolation of three new hetisine-type diterpenoid alkaloids, named orochrine (1), 2-O-acetylorochrine (2), and 2-O-acetyl-7alpha-hydroxyorochrine (3), together with the previously reported alkaloids atisinium chloride (4) and virescenine (5). The structures of the new alkaloids were elucidated by spectroscopic data analysis.
Wangchuk
Phurpa
P
Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
Bremner
John B
JB
Samosorn
Siritron
S
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D001631:Bhutan; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
C525475:2-O-acetyl-7alpha-hydroxyorochrine; C525474:2-O-acetylorochrine; D000470:Alkaloids; D004224:Diterpenes; C525473:orochrine