Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells.
Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.
Isada
Tetsuro
T
Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
Hirose
Munetaka
M
Murata
Eri
E
Okayama
Yoko
Y
Takatori
Mayumi
M
Tani
Mayumi
M
Fukazawa
Keita
K
Hirata
Masashi
M
Taniguchi
Satoshi
S
Shigemi
Kenji
K
Tanaka
Yoshifumi
Y
D000399:Air Pressure; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000032:analysis / Q000378:metabolism; D020932:Nerve Growth Factor / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D016716:PC12 Cells; D010766:Phosphorylation; D051381:Rats; D020917:Receptor, trkA / Q000378:metabolism
D020932:Nerve Growth Factor; D020917:Receptor, trkA; D048049:Extracellular Signal-Regulated MAP Kinases