title: The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk.
abstract: Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma PAI-1. The 4G allele is associated with higher levels of PAI-1, and might increase the risk for intravascular thrombosis. However, the contribution of this genetic variant to the risk for thrombosis, both arterial and venous, has not been clearly established. A broad spectrum of findings regarding the effect of the 4G allele on thrombotic risk in different target organs has been reported. Our aim is to summarize the variable influence of this polymorphism on thrombotic events in different tissues or organs and explain the underlying mechanisms accounting for these differences.
authors.affiliation: Laboratory of Hematology & Blood Bank Unit, Attikon General Hospital, School of Medicine, University of Athens, Greece. atsantes@yahoo.com
authors.forename: Argirios E
authors.initials: AE
authors.lastname: Tsantes
authors.forename: Georgios K
authors.initials: GK
authors.lastname: Nikolopoulos
authors.forename: Pantelis G
authors.initials: PG
authors.lastname: Bagos
authors.forename: Stefanos
authors.initials: S
authors.lastname: Bonovas
authors.forename: Petros
authors.initials: P
authors.lastname: Kopterides
authors.forename: Georgios
authors.initials: G
authors.lastname: Vaiopoulos
mesh_terms: D002545:Brain Ischemia / Q000209:etiology / Q000235:genetics; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D020521:Stroke / Q000209:etiology / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*; D054556:Venous Thromboembolism / Q000209:etiology / Q000235:genetics
chemical_list: D017395:Plasminogen Activator Inhibitor 1