[Enhanced structural transformations in DNA macromolecules exposed to weak thermalized neutron field].
We examined now an ultraweak thermalized neutron field (UTNF) affects the structural transformation in DNA macromolecules at room temperature. IR-spectroscopy, electrophoresis, and filtration through nitrocellulose filter measurements revealed that UTNF irradiation with a fluence of F(n) - 1.0 - 3.7 x 10(7) n/cm2 (the absorbed dose as low as 10 - 50 microGy) can induce non negligible structural changes in DNA macromolecules in film as well as in an aqueous solution. These structural changes appear as a type of reversible conformational transition from the A-form to a disordered state, as well as through intermolecular cross-link formations and the generation of double-strand breaks.
Lipson
A G
AG
Zhizhina
G P
GP
Burlakova
E B
EB
Miley
G H
GH
Saunin
E I
EI
Tsivadze
Iu
Iu
Serebriakova
N V
NV
D000818:Animals; D002417:Cattle; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D044704:DNA, A-Form / Q000737:chemistry*; D004586:Electrophoresis; D051379:Mice; D009502:Neutrons; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D013055:Spectrophotometry, Infrared
D044704:DNA, A-Form