title: A new micro minimally invasive biopsy tool for molecular analysis.
abstract: In this paper, we present a new micro minimally invasive biopsy tool adapted to proteomic mass spectrometry analysis. The concept is born from a multidisciplinary collaboration in the field of proteomics, cancer research and microtechnology. In mixing different skills, we have developed and manufactured a miniaturized biopsy tool using microtechnology techniques in order to minimize tissue damage. Dedicated chemically functionalized zones were added to the device in order to increase capture yield, and specificity during tissue apposition. Fields of application range are from cancer research to neurodegenerative diseases study.
authors.affiliation: CEA-LETI, Grenoble, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Cosnier
authors.forename: F
authors.initials: F
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Bouamrani
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: P
authors.initials: P
authors.lastname: Caillat
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D009363:Neoplasm Proteins / Q000032:analysis*; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000379:methods; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins