Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis.
Gadolinium (Gd)-based paramagnetic contrast agents are relatively safe when used in clinically recommended doses. However, with the rapidly expanding body of literature linking Gd-based paramagnetic contrast agents and nephrogenic systemic fibrosis (NSF), awareness of the potential side effects and adverse reactions from Gd is now an important requirement for practicing radiologists. In addition to the ongoing accumulation and analyses of clinical NSF data, it is also essential for the practicing radiologist to understand the biochemical characteristics of the extracellular Gd-chelates. The purpose of this review is to consolidate and update the available information on known side effects, adverse reactions, and toxicity of the Gd chelates, with particular emphasis on the potential mechanisms of NSF.
Ersoy
Hale
H
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. hersoy@partners.org
Rybicki
Frank J
FJ
D003287:Contrast Media / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005355:Fibrosis; D005682:Gadolinium / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000517:prevention & control; D012871:Skin Diseases / Q000139:chemically induced* / Q000517:prevention & control
D003287:Contrast Media; D005682:Gadolinium