title: Pharmaceutical applications of hot-melt extrusion: Part II.
abstract: The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. marepka@olemiss.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Repka
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Battu
authors.forename: Sampada B
authors.initials: SB
authors.lastname: Upadhye
authors.forename: Sridhar
authors.initials: S
authors.lastname: Thumma
authors.forename: Michael M
authors.initials: MM
authors.lastname: Crowley
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Charles
authors.initials: C
authors.lastname: Martin
authors.forename: James W
authors.initials: JW
authors.lastname: McGinity
mesh_terms: D002214:Capsules; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D011786:Quality Control; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D013607:Tablets