title: MEMS fabricated chip for an implantable drug delivery device.
abstract: We present a silicon-based implantable drug delivery system (IDDS) for the administration of compounds in vivo. The implanted device contains the drug-filled silicon microchip, control circuitry, telemetry capability, and a battery. At the heart of the IDDS is the drug-containing microchip, a MEMS (MicroElectroMechanical Systems)-based device. A process was developed for the fabrication of the silicon chip. MicroCHIPS' drug release technology has been successfully demonstrated in vitro and in vivo using the therapeutic peptide leuprolide as a model compound.
authors.affiliation: MicroCHIPS Inc., Bedford, MA, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Sbiaa
mesh_terms: D015374:Biosensing Techniques; D016503:Drug Delivery Systems; D004343:Drug Implants; D004867:Equipment Design; D006801:Humans; D015918:Infusion Pumps, Implantable; D007700:Kinetics; D016729:Leuprolide / Q000008:administration & dosage; D008422:Materials Testing; D008838:Microcomputers; D008904:Miniaturization; D010455:Peptides / Q000008:administration & dosage; D012825:Silicon / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods
chemical_list: D004343:Drug Implants; D010455:Peptides; D016729:Leuprolide; D012825:Silicon