Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors.
Disruption of lipopolysaccharide (LPS) biosynthesis genes in an epidemiologically significant Yersinia pestis strain showed that the ability to synthesize the full inner core of the LPS is crucial for resistances to the bactericidal action of antimicrobial peptides and to complement-mediated serum killing. Resistance to polymyxin B also requires a high content of the cationic sugar, 4-amino-4-deoxy-L-arabinose, in lipid A.
Knirel
Yuriy A
YA
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. knirel@ioc.ac.ru
Dentovskaya
Svetlana V
SV
Bystrova
Olga V
OV
Kocharova
Nina A
NA
Senchenkova
Sof'ya N
SN
Shaikhutdinova
Rima Z
RZ
Titareva
Galina M
GM
Bakhteeva
Irina V
IV
Lindner
Buko
B
Pier
Gerald B
GB
Anisimov
Andrey P
AP
D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D001770:Blood Bactericidal Activity; D002240:Carbohydrate Sequence; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009154:Mutation; D011112:Polymyxin B / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D015010:Yersinia pestis / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics
D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D011112:Polymyxin B