title: Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
abstract: 4-Amino analogues prepared from beta-boswellic acid and 11-keto-beta-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
authors.affiliation: Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.
authors.forename: Bhahwal A
authors.initials: BA
authors.lastname: Shah
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gupta
authors.forename: Madhunika
authors.initials: M
authors.lastname: Sharma
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Sethi
authors.forename: Ajit K
authors.initials: AK
authors.lastname: Saxena
authors.forename: Jaswant
authors.initials: J
authors.lastname: Singh
authors.forename: Ghulam N
authors.initials: GN
authors.lastname: Qazi
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D029743:Boswellia / Q000737:chemistry; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects; D006131:Growth Inhibitors / Q000633:toxicity*; D006801:Humans; D014315:Triterpenes / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D014315:Triterpenes; C054625:boswellic acid