Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.
Refractory T-lymphoblastic leukemia in adults has a poor prognosis in patients who relapse after allogeneic stem cell transplantation, and relatively few new agents have demonstrated activity. Clofarabine is a novel nucleoside analog that has been associated with significant clinical activity in relapsed pediatric B-ALL. We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias.
Choi
Jaehyuk
J
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Foss
Francine
F
D000227:Adenine Nucleotides / Q000627:therapeutic use*; D000328:Adult; D001087:Arabinonucleosides / Q000494:pharmacology / Q000627:therapeutic use*; D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000556:secondary; D002986:Clinical Trials as Topic; D000077866:Clofarabine; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy*; D008297:Male; D012008:Recurrence; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D000227:Adenine Nucleotides; D001087:Arabinonucleosides; C104457:nelarabine; D000077866:Clofarabine