Determining the efficacy of dietary phytochemicals in cancer prevention.
Accumulating data suggest that dietary phytochemicals have the potential to moderate deregulated signalling or reinstate checkpoint pathways and apoptosis in damaged cells, while having minimal impact on healthy cells. These are ideal characteristics for chemopreventive and combination anticancer strategies, warranting substantial research effort into harnessing the biological activities of these agents in disease prevention and treatment. However, this requires further investigation into their mode of action and novel approaches to the development of reliable biomarkers.
Manson
M M
MM
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Biocentre, University of Leicester, Leicester LE1 7RH, U.K. mmm2@le.ac.uk
Foreman
B E
BE
Howells
L M
LM
Moiseeva
E P
EP
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D004032:Diet; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D014411:Neoplastic Stem Cells / Q000166:cytology; D010944:Plants / Q000737:chemistry*; D012307:Risk Factors
D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor