Retinoblastoma teaches a new lesson.
In this issue, Ajioka et al. (2007) report a new mouse model of retinoblastoma. They show that retinoblastoma is not driven by uncontrolled expansion of retinal progenitor cells, but rather is the result of cell cycle re-entry and expansion of differentiated horizontal interneurons in the retina.
te Riele
Hein
H
Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. h.t.riele@nki.nl
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D007395:Interneurons / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D012160:Retina / Q000473:pathology; D019572:Retinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D012175:Retinoblastoma / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D013234:Stem Cells / Q000473:pathology*