[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people].
In the course of aging both monkeys and people reveal decreased night and average daily level of melatonin in the blood plasma and reduced hormone circadian rhythm amplitude, which evidence the disorder of the pineal gland melatonin releasing function. Peptide preparations of the pineal gland (Epithalamin--a complex of peptides isolated from the pineal gland and Epitalon--synthetic tetrapeptide) recover night release of endogenous melatonin and lead to the normalization of the hormone circadian rhythm in the blood plasma. In elderly people Epithalamin and Epitalon modulate pineal gland functional state: people with pineal gland functional insufficiency report an increase of night melatonin level. The preparations of the pineal gland, effectively increasing melatonin concentration and having no side effects, can be used in clinical geriatric practice.
Korkushko
O V
OV
Lapin
B A
BA
Goncharova
N D
ND
Khavinson
V Kh
VKh
Shatilo
V B
VB
Vengerin
A A
AA
Antoniuk-Shcheglova
I A
IA
Magdich
L V
LV
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010870:Pineal Gland / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism
D009842:Oligopeptides; D010455:Peptides; C027437:epithalamin; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine