Treatment of alcoholic liver disease.
Severe alcoholic steatohepatitis (ASH) is the major complication of advanced alcoholic liver disease (ALD) and has a high mortality even when treated with corticosteroids. Despite the importance of reactive oxygen species in the pathophysiology of ALD and ASH, antioxidants provide no benefit in the treatment of patients with ASH. Proinflammatory cytokines are important in the pathophysiology of ALD and might mediate most of the inflammatory aspects of these disorders. New treatment modalities in ASH might involve antagonism of proinflammatory cytokines such as tumor necrosis factor (TNF) by specific antibodies or other TNF-interfering treatment strategies. Propylthiouracil and S-adenosyl methionine may be beneficial to patients with alcoholic cirrhosis, but both require further randomized, controlled trials before their use can be recommended.Liver transplantation is an effective therapy for patients with advanced alcoholic cirrhosis who have not recovered after a period of abstinence.
Day
Christopher Paul
CP
Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D019587:Dietary Supplements; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D010431:Pentoxifylline / Q000627:therapeutic use; D011379:Prognosis; D011441:Propylthiouracil / Q000627:therapeutic use; D013695:Temperance; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000975:Antioxidants; D014409:Tumor Necrosis Factor-alpha; D011441:Propylthiouracil; D010431:Pentoxifylline; D003078:Colchicine