title: Macrophage and TGF-beta immunohistochemical expression in Jorge Lobo's disease.
abstract: Jorge Lobo's disease, or lacaziosis, is a chronic deep mycosis that clinically manifests as solid, variable-sized nodular parakeloidal lesions. Few studies have characterized the in situ cellular and humoral immune response, especially the involvement of cytokines with immunosuppressive effects such as TGF-beta. The objective this paper was to analyze the expression of TGF-beta in cutaneous lesions in lacaziosis and investigate its importance in the etiopathogy of the disease. The results indicate that the abundance of collagen bands, together with weak immunolabeling for CD68 seen in macrophages, indicates a concomitant effect of TGF-beta inhibiting macrophages and inducing fibrosis, which is responsible for the keloid aspect frequently acquired by these lesions. Finally, the evolution of the infection supports the hypothesis that TGF-beta plays a fundamental role in the etiopathology of Lacazia loboi infection, either by inhibiting the cellular immune response mainly mediated by macrophages or by inducing fibrosis. Further studies are necessary to better characterize the phenotype of the inflammatory infiltrate as well as the participation of other cytokines and growth factors in the tissue response of the host in Jorge Lobo's disease.
authors.affiliation: Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém-PA 66055-240, Brazil.
authors.forename: Marilia Brasil
authors.initials: MB
authors.lastname: Xavier
authors.forename: Rosana Maria Feio
authors.initials: RM
authors.lastname: Libonati
authors.forename: Débora
authors.initials: D
authors.lastname: Unger
authors.forename: Clívia
authors.initials: C
authors.lastname: Oliveira
authors.forename: Carlos Eduardo Pereira
authors.initials: CE
authors.lastname: Corbett
authors.forename: Arival Cardoso
authors.initials: AC
authors.lastname: de Brito
authors.forename: Juarez Antonio Simões
authors.initials: JA
authors.lastname: Quaresma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000166:cytology / Q000276:immunology / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta