Resistin- and Obesity-associated metabolic diseases.
The link between obesity and diabetes is strong as well as complex. Fat cells produce many circulating regulators of insulin sensitivity, including pro-inflammatory cytokines. In rodents, resistin is produced by adipose tissue, and is a significant regulator of glucose metabolism and insulin sensitivity. In humans, resistin is derived made mainly from macrophages. Given the emerging interrelationship between inflammation and metabolic disease, hyperresistinemia may be a biomarker, and/or a mediator, of metabolic and inflammatory diseases in humans as well as in rodents.
Lazar
M A
MA
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6149, USA. lazar@mail.med.upenn.edu
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D030801:Animals, Genetically Modified; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004703:Endocrine System / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D008659:Metabolic Diseases / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D047495:PPAR gamma / Q000235:genetics / Q000502:physiology; D052243:Resistin / Q000235:genetics / Q000502:physiology*; D012377:Rodentia; D015398:Signal Transduction / Q000235:genetics; D014652:Vascular Diseases / Q000209:etiology / Q000235:genetics
D047495:PPAR gamma; D052243:Resistin