Prophylactic antiemetic effect of midazolam after middle ear surgery.
OBJECTIVE
To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.


METHODS
A prospective, randomized, double-blind, placebo-controlled study.


METHODS
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.


RESULTS
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.


CONCLUSIONS
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.
Jung
Jae Sik
JS
Department of Anesthesiology, Kyungpook National University Hospital, Jung-Gu, Daegu, Republic of Korea.
Park
Jun Sik
JS
Kim
Si Oh
SO
Lim
Dong Gun
DG
Park
Sung Sik
SS
Kwak
Kyung Hwa
KH
Cho
Jin Duck
JD
Jeon
Young Hoon
YH
D000932:Antiemetics / Q000008:administration & dosage / Q000592:standards* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D014433:Tympanoplasty
D000932:Antiemetics; D006993:Hypnotics and Sedatives; D008874:Midazolam