Fusion of enveloped virus nanoparticles with polyelectrolyte-supported lipid membranes for the design of bio/nonbio interfaces.
Fusion of lipid-enveloped viruses with endosomal membranes triggered by low pH in the endosome is a key step in the course of viral infection. This ubiquitous mechanism can be used to integrate functional nanoparticles of viral origin into composite materials consisting of a polyelectrolyte multilayer with an adsorbed lipid membrane in a natural and biomimetic way. Polyelectrolyte multilayers as the support for the lipid membrane are a versatile means to combine the biological functions of the viral surface with the multiplicity of polyelectrolyte borne functions into a novel bio/nonbio composite material.
Fischlechner
Martin
M
Institute of Medical Physics and Biophysics, Leipzig University, Leipzig, Germany. mrtin.fischlechner@medizin.uni-leipzig.de
Reibetanz
Uta
U
Zaulig
Markus
M
Enderlein
Dirk
D
Romanova
Julia
J
Leporatti
Stefano
S
Moya
Sergio
S
Donath
Edwin
E
D001672:Biocompatible Materials / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry*; D011992:Endosomes / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry; D008566:Membranes / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties; D013997:Time Factors; D014759:Viral Envelope Proteins / Q000737:chemistry*; D014780:Viruses / Q000378:metabolism
D001672:Biocompatible Materials; D003102:Colloids; D004573:Electrolytes; D008055:Lipids; D014759:Viral Envelope Proteins