Sodium renal imaging in mice at high magnetic fields.
This work presents the first sodium MRI functional renal study on a mouse model. The tissue sodium concentration was monitored during induced diuresis with furosemide. By using density-weighted chemical shift imaging (DWCSI) at high field strength a temporal resolution of less than 5 min for three dimensional (3D) data sets with high spatial resolution was achieved. A maximum increase of 20% in the cortex and a decrease of 45% of the original signal strength in the medulla were observed. These findings correspond well with experiments conducted on much larger rodent models.
Neuberger
Thomas
T
Department of Experimental Physics V, University of Würzburg, Würzburg, Germany.
Gulani
Vikas
V
Webb
Andrew
A
D000818:Animals; D004232:Diuretics / Q000008:administration & dosage; D005665:Furosemide / Q000008:administration & dosage; D007668:Kidney / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D051379:Mice; D011859:Radiography; D012964:Sodium / Q000502:physiology*
D004232:Diuretics; D005665:Furosemide; D012964:Sodium