A water-soluble, small molecular fluorescent sensor with femtomolar sensitivity for zinc ion.
A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to zinc ion and also exhibits high selectivity to zinc ion over other physiological relevant divalent metals in the presence of EDTA. X-ray crystal structure of zinc complex reveals that an acetic carboxylic group participates in coordination, which significantly enhances the affinity of 1 for zinc ion.
Wang
Huan-Huan
HH
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080 P. R. China.
Gan
Quan
Q
Wang
Xiao-Jun
XJ
Xue
Lin
L
Liu
Sheng-Hua
SH
Jiang
Hua
H
D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D012995:Solubility; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D014867:Water; D015032:Zinc