title: Cyclic Cushing syndrome: definitions and treatment implications.
abstract: Endogenous Cushing syndrome (CS) results from hypercortisolemia caused by excess adrenocorticotropic hormone production in a pituitary adenoma or ectopic tumor, or by an adrenal tumor that directly produces excess cortisol. The diagnosis can usually be ascertained with a reasonable degree of certainty based on clinical and laboratory findings of hypercortisolism. There are patients, however, in whom the production of excess cortisol exhibits a cyclic or intermittent pattern, and, as a result, the clinical symptoms may be quite complex and varied. In these patients the hypothalamic-pituitary-adrenal axis may be normal between cycles, and dexamethasone suppression testing may produce a paradoxical response. In the present article, the authors provide a definition of cyclic Cushing syndrome, review the causes and its potential pathophysiological mechanisms, and discuss the treatment options based on a review of the available literature.
authors.affiliation: Seattle Neuroendocrine Program, Swedish Neuroscience Institute, Seattle, Washington, USA.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Velez
authors.forename: Marc R
authors.initials: MR
authors.lastname: Mayberg
authors.forename: William H
authors.initials: WH
authors.lastname: Ludlam
mesh_terms: D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D010913:Pituitary-Adrenal System / Q000503:physiopathology
chemical_list: D006854:Hydrocortisone