title: [Influence of the chronic gamma-irradiation at the low doses during the near ontogenesis periods on the oxidative processes in rodent organs].
abstract: It is shown that the effect of the low intensity gamma-irradiation at the dose of 5.5 cGy during the 4 months including the antenatal period causes the most substantial changes of the peroxide content in the liver and in brain lipids and of TBA-reactive substances amount in organs and blood plasma of tundra vole F2 which are reproduced from parents during long-term inhabiting on the Ra-contaminated area in the Komi Republic. The consequences of the chronic gamma-irradiation at the doses of 4 cGy (the dose rate is 5 mR/h) and 31 cGy (the dose rate is 40 mR/h) are studied by the morphophysiological and by biochemical parameters in organs of mice CBA (males) within 3 months after exposure. The change of the scale of the interrelation between the liver and body masses and also between the sums of the more easily to the more poorly oxidizable fractions and the phosphatidyl choline to phosphatidyl ethanolamine ratio in the liver phospholipids in groups of the irradiated mice is found as compared with that in the control group. The absence of interrelation between the lipid peroxidation process intensity and the catalase activity in the murine liver and also between the disbalance of the biochemical functions and the dose rate and/or the dose of the gamma-irradiation is revealed. The analysis of the data obtained allow to conclude that the chronic gamma-radiation under low intensity has the systemic effect on the animal organism causing of its function on the other level.
authors.forename: N G
authors.initials: NG
authors.lastname: Zagorskaia
authors.forename: A G
authors.initials: AG
authors.lastname: Kudiasheva
authors.forename: O G
authors.initials: OG
authors.lastname: Shevchenko
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
mesh_terms: D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000528:radiation effects*; D001923:Brain Chemistry / Q000528:radiation effects; D002374:Catalase / Q000032:analysis; D005720:Gamma Rays / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000528:radiation effects; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000528:radiation effects; D010545:Peroxides / Q000032:analysis; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D010545:Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase