title: Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence.
abstract: In this study, a turbo spin-echo (TSE) based motion-sensitized driven-equilibrium (MSDE) sequence was used as an alternative black-blood (BB) carotid MRI imaging scheme. The MSDE sequence was first optimized for more efficient residual blood signal suppression in the carotid bulb of healthy volunteers. Effective contrast-to-noise ratio (CNR(eff)) and residual signal-to-noise ratio (SNR) in the lumen measured from MSDE images were then compared to those measured from inflow saturation (IS) and double inversion-recovery (DIR) images. Statistically significant higher CNR(eff) and lower lumen SNR were obtained from MSDE images. To assess MSDE sequence in a clinical carotid protocol, 42 locations from six subjects with 50% to 79% carotid stenosis by duplex ultrasound were scanned with both MSDE and multislice DIR. The comparison showed that MSDE images present significantly higher CNR and lower lumen SNR compared to corresponding multislice DIR images. The vessel wall area and mean wall thickness measurements in MSDE images were slightly but significantly lower than those obtained with other blood suppression techniques. In conclusion, in vivo comparisons demonstrated that MSDE sequence can achieve better blood suppression and provide a more accurate depiction of the lumen boundaries by eliminating plaque mimicking artifacts in carotid artery (CA) imaging.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, USA. jnwang@u.washington.edu
authors.forename: Jinnan
authors.initials: J
authors.lastname: Wang
authors.forename: Vasily L
authors.initials: VL
authors.lastname: Yarnykh
authors.forename: Thomas
authors.initials: T
authors.lastname: Hatsukami
authors.forename: Baocheng
authors.initials: B
authors.lastname: Chu
authors.forename: Niranjan
authors.initials: N
authors.lastname: Balu
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
mesh_terms: D016477:Artifacts; D002340:Carotid Artery Diseases / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans