title: Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases.
abstract: The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40 Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.
authors.affiliation: Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. jsalgueiro@ffyb.uba.ar
authors.forename: M J
authors.initials: MJ
authors.lastname: Salgueiro
authors.forename: H
authors.initials: H
authors.lastname: Durán
authors.forename: M
authors.initials: M
authors.lastname: Palmieri
authors.forename: R
authors.initials: R
authors.lastname: Pirchio
authors.forename: J
authors.initials: J
authors.lastname: Nicolini
authors.forename: R
authors.initials: R
authors.lastname: Ughetti
authors.forename: M L
authors.initials: ML
authors.lastname: Papparella
authors.forename: G
authors.initials: G
authors.lastname: Casale
authors.forename: M
authors.initials: M
authors.lastname: Zubillaga
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods*; D017608:Chromium Compounds / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006651:Histocytochemistry; D051379:Mice; D018632:Mice, Inbred SENCAR; D010710:Phosphates / Q000008:administration & dosage / Q000737:chemistry; D010756:Phosphoric Acids / Q000008:administration & dosage / Q000737:chemistry; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry; D011880:Radiotherapy Planning, Computer-Assisted; D011897:Random Allocation; D012408:Rubber / Q000008:administration & dosage / Q000737:chemistry; D012828:Silicones / Q000008:administration & dosage / Q000737:chemistry; D012878:Skin Neoplasms / Q000532:radiotherapy*
chemical_list: D017608:Chromium Compounds; D010710:Phosphates; D010756:Phosphoric Acids; D010761:Phosphorus Radioisotopes; D012828:Silicones; D012408:Rubber; C509369:chromic phosphate; C030242:phosphoric acid