title: Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?
abstract: In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133-1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794-800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.
authors.affiliation: School of Medical Sciences, University of Aberdeen, IMS Building, Foresterhill, Aberdeen AB25 2ZD, U.K. b.mueller@abdn.ac.uk
authors.forename: B
authors.initials: B
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Blackburn
authors.forename: C
authors.initials: C
authors.lastname: Feijoo
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: C
authors.initials: C
authors.lastname: Smythe
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004261:DNA Replication; D015870:Gene Expression; D006657:Histones / Q000235:genetics*; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D006657:Histones; D012333:RNA, Messenger; D019869:Phosphatidylinositol 3-Kinases