[Expressions and significance of B7-H1 and programmed death-1 in lymphocytes from patients with chronic hepatitis B virus infection].
OBJECTIVE
To examine the expressions of B7-H1 and its receptor programmed death-1 (PD-1) on circulating T cells and myeloid dendritic cells (mDCs) in patients with chronic hepatitis B virus (HBV) infection and to investigate the correlation between their expressions and their disease status.


METHODS
The expressions of B7-H1 and PD-1 on mDCs and T lymphocytes in 30 patients with chronic HBV infection and 28 healthy controls were analyzed by a fluorescence-activated cell sorter (FACS). Real time-polymerase chain reaction (RT-PCR) was used to measure the serum HBV DNA load.


RESULTS
Both B7-H1 and PD-1 were significantly upregulated on T cells and mDCs in those patients. Their expressions were positively correlated with the patients serum ALT levels and HBV DNA loads.


CONCLUSIONS
B7-H1 and PD-1 expressions in our patients with chronic hepatitis B are closely associated with their disease status.
Li
Yong-gang
YG
302 Hospital of PLA, Beijing 100039, China.
Chen
Liang-en
LE
Chen
Guo-feng
GF
Wang
Fu-sheng
FS
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D060890:B7-H1 Antigen; D016022:Case-Control Studies; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D019694:Hepatitis B, Chronic / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000378:metabolism*; D055815:Young Adult
D015703:Antigens, CD; D060890:B7-H1 Antigen; C423236:CD274 protein, human