The genetic predisposition to adverse outcome after trauma.
Technological advances and shorter rescue times have allowed early and effective resuscitation after trauma and brought attention to the host response to injury. Trauma patients are at risk of progressive organ dysfunction from what appears to be an uncontrolled immune response. The availability of improved techniques of molecular diagnosis has allowed investigation of the role of genetic variations in the inflammatory response to post-traumatic complications and particularly to sepsis. This review examines the current evidence for the genetic predisposition to adverse outcome after trauma. While there is evidence supporting the involvement of different polymorphic variants of genes in determining the post-traumatic course and the development of complications, larger-scale studies are needed to improve the understanding of how genetic variability influences the responses to post-traumatic complications and pharmacotherapy.
Giannoudis
P V
PV
Department of Trauma and Orthopaedics, Clarendon Wing, Floor A, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. pgiannoudi@aol.com
van Griensven
M
M
Tsiridis
E
E
Pape
H C
HC
D002352:Carrier Proteins / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications / Q000235:genetics* / Q000276:immunology; D014947:Wounds and Injuries / Q000235:genetics*
D002352:Carrier Proteins; D016207:Cytokines