title: Acral erythema with oral methotrexate in a child.
abstract: Acral erythema is a rare cutaneous reaction that has been associated with various chemotherapy regimens. Most occurrences have been described in adult patients. Recently, methotrexate has been implicated in the development of acral erythema; however, pediatric reports are few. All of the reports in the pediatric and adult literature have described patients receiving moderate to high-dose intravenous methotrexate. Here, we describe an instance of standard-dose oral methotrexate-associated acral erythema in a young girl with acute lymphoblastic leukemia, and review the recent literature as it relates to pediatric patients.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine and Yale New Haven Hospital, New Haven, Connecticut, USA. varela@email.chop.edu
authors.forename: Carly R
authors.initials: CR
authors.lastname: Varela
authors.forename: Joseph
authors.initials: J
authors.lastname: McNamara
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Antaya
mesh_terms: D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D003875:Drug Eruptions / Q000473:pathology*; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006225:Hand; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate