Complete genome sequence of the myxobacterium Sorangium cellulosum.
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
Schneiker
Susanne
S
Department of Genetics, Bielefeld University, PO Box 100131, D-33501 Bielefeld, Germany.
Perlova
Olena
O
Kaiser
Olaf
O
Gerth
Klaus
K
Alici
Aysel
A
Altmeyer
Matthias O
MO
Bartels
Daniela
D
Bekel
Thomas
T
Beyer
Stefan
S
Bode
Edna
E
Bode
Helge B
HB
Bolten
Christoph J
CJ
Choudhuri
Jomuna V
JV
Doss
Sabrina
S
Elnakady
Yasser A
YA
Frank
Bettina
B
Gaigalat
Lars
L
Goesmann
Alexander
A
Groeger
Carolin
C
Gross
Frank
F
Jelsbak
Lars
L
Jelsbak
Lotte
L
Kalinowski
Jörn
J
Kegler
Carsten
C
Knauber
Tina
T
Konietzny
Sebastian
S
Kopp
Maren
M
Krause
Lutz
L
Krug
Daniel
D
Linke
Bukhard
B
Mahmud
Taifo
T
Martinez-Arias
Rosa
R
McHardy
Alice C
AC
Merai
Michelle
M
Meyer
Folker
F
Mormann
Sascha
S
Muñoz-Dorado
Jose
J
Perez
Juana
J
Pradella
Silke
S
Rachid
Shwan
S
Raddatz
Günter
G
Rosenau
Frank
F
Rückert
Christian
C
Sasse
Florenz
F
Scharfe
Maren
M
Schuster
Stephan C
SC
Suen
Garret
G
Treuner-Lange
Anke
A
Velicer
Gregory J
GJ
Vorhölter
Frank-Jörg
FJ
Weissman
Kira J
KJ
Welch
Roy D
RD
Wenzel
Silke C
SC
Whitworth
David E
DE
Wilhelm
Susanne
S
Wittmann
Christoph
C
Blöcker
Helmut
H
Pühler
Alfred
A
Müller
Rolf
R
D001483:Base Sequence; D001709:Biotechnology; D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D009231:Myxococcales / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D010802:Phylogeny; D017422:Sequence Analysis, DNA