title: Evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in Poland from 1991 to 2001.
abstract: A retrospective analysis was performed of 12,888 cases of larynx and hypopharynx carcinoma diagnosed in 19 ENT Departments in Poland during an 11-year period from 1991 to 2001. An assessment of basic epidemiological data, including also tumor site and disease stage at the time of diagnosis, was conducted. Epidemiological trends over the 11-year period of the analysis were examined. The average M:F proportion was 8:1, with a significant increase in the number of female patients during the analyzed period. The predominant localization of carcinoma was in the glottis (47.2%), followed by the supraglottis (40.3%) and pyriform sinus (7.8%). A significant increase in pyriform sinus tumors was observed in the analyzed period. Majority of cases (57.4%) presented with local advanced stage (T3+T4) carcinoma of the larynx and hypopharynx, with the highest rate (81.0%) for the pyriform sinus carcinomas, and with the lowest rate for glottic tumors (41.8%). Regional lymph node metastases were diagnosed in 47.7% of the analyzed cases, with the highest rate (82.2%) in cases of pyriform sinus carcinomas, and the lowest (31.7%) in glottic carcinomas. In the 11-year period, a significant drop in N0 cases and a tendency toward increased rates of N2 and N3 lymph nodes metastases cases of supraglottic carcinoma were observed. Distant metastases at the time of diagnosis were registered in 2.2% of the analyzed cases, with the highest percentage in the posterior pharyngeal wall (7.6%) and pyriform sinus (7.4%) carcinomas.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Holy Cross Cancer Center, Artwinskiego 3, 25-734 Kielce, Poland. Stanislaw.bien@onkol.kielce.pl
authors.forename: Stanisław
authors.initials: S
authors.lastname: Bień
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Kamiński
authors.forename: Stanisław
authors.initials: S
authors.lastname: Zyłka
authors.forename: Ryszard
authors.initials: R
authors.lastname: Mezyk
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Piasta
mesh_terms: D000328:Adult; D017677:Age Distribution; D005260:Female; D005931:Glottis; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies