A case with transient increases in serum S100A8/A9 levels implying acute inflammatory responses after pancreatic islet transplantation.
We investigated a patient with type 1 diabetes mellitus undergoing pancreatic islets transplantation. In this patient, we evaluated the clinical usefulness of serial measurement of serum S100A8/A9 complex levels for detecting acute inflammatory responses associated with rejection of transplanted pancreatic islets. The serum S100A8/A9 complex was a more sensitive marker for acute inflammation associated with islet transplant rejection than the serum C-reactive protein. Thus, the serial measurement of the serum S100A8/A9 complex concentration is useful for monitoring the patients with pancreatic islet transplantation.
Ikemoto
Masaki
M
Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Matsumoto
Shinichi
S
Egawa
Hiroto
H
Okitsu
Teru
T
Iwanaga
Yasuhiro
Y
Umemoto
Shinji
S
Itoh
Hiroshi
H
Murayama
Hiroshi
H
Fujita
Masatoshi
M
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D040501:Calgranulin A / Q000097:blood*; D040502:Calgranulin B / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology*; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis
D015415:Biomarkers; D001786:Blood Glucose; D040501:Calgranulin A; D040502:Calgranulin B; D002097:C-Reactive Protein; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase