Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification.
The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.
Bao
Kai
K
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Zhang
Weige
W
Zhang
Chuanliang
C
Qu
Yingwei
Y
Tian
Liang
L
Wu
Lan
L
Zhao
Xiang
X
Cheng
Maosheng
M
D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004951:Esterification; D008872:Microwaves
D004917:Erythromycin