Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size.
OBJECTIVE
We examined the serum levels of interferon-gamma-inducible protein 10 (IP-10), an inflammation-induced chemokine, in acute myocardial infarction (AMI).


METHODS
The subjects were 33 AMI patients, 20 stable angina pectoris patients (AP) and 20 normal subjects. In AMI patients, blood samples were collected before percutaneous coronary intervention (PCI) and on days 3, 7 and 28.


RESULTS
Patients with AMI showed significantly higher serum IP-10 levels (137.5+/-79.8 pg/mL) than control subjects (91.2+/-40.1 pg/mL) and patients with AP (93.3+/-41.1 pg/mL). The serum IP-10 level before PCI was negatively correlated with infarct size, as indicated by cumulative release of creatine kinase (CK) and peak CK and its isoenzyme CK-MB. Stepwise multiple regression analysis revealed that the serum IP-10 level before PCI was an independent predictor of cumulative CK release.


CONCLUSIONS
The serum IP-10 level was increased in AMI, and a higher level of serum IP-10 before PCI may be informative regarding infarct size.
Koten
Kazuya
K
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Hirohata
Satoshi
S
Miyoshi
Toru
T
Ogawa
Hiroko
H
Usui
Shinichi
S
Shinohata
Ryoko
R
Iwamoto
Mutsumi
M
Kitawaki
Tomoki
T
Kusachi
Shozo
S
Sakaguchi
Kosaku
K
Ohe
Tohru
T
D000368:Aged; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood*; D017023:Coronary Angiography; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D018450:Disease Progression; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology*; D016277:Ventricular Function, Left
C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form