Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations.
Several neurological diseases are related to oxidative stress (OS) and neurotoxicity. Considering that physical exercise may exert beneficial effects on antioxidant defenses, our objective was to evaluate the influence of a swimming exercise on an OS animal model (reserpine-induced orofacial dyskinesia). In this model, the increased dopamine metabolism can generate OS and neuronal degeneration, causing involuntary movements. The increase in vacuous chewing movements and facial twitching caused by reserpine (1 mg/kg s.c.) was partially prevented by exercise. An increase in catalase activity and a decrease in GSH levels were observed in the striatum. Physical training did not change the effects of reserpine on catalase, however it partially recovered GSH. Exercise per se caused a significant GSH decrease. There was a positive correlation between catalase and OD (r=0.41; r=0.47, P<0.05) and a negative correlation between GSH and OD (r=0.61; r=0.71, P<0.05). These results reveal the benefit of exercise in attenuating the motor disorder related to OS.
Teixeira
Angélica M
AM
Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
Trevizol
Fabíola
F
Colpo
Gabriela
G
Garcia
Solange C
SC
Charão
Mariele
M
Pereira
Romaiana P
RP
Fachinetto
Roselei
R
Rocha
João B T
JB
Bürger
Marilise E
ME
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000633:toxicity; D001923:Brain Chemistry / Q000187:drug effects; D002374:Catalase / Q000097:blood; D004409:Dyskinesia, Drug-Induced / Q000523:psychology; D005978:Glutathione / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D012110:Reserpine / Q000494:pharmacology* / Q000633:toxicity
D000975:Antioxidants; D014150:Antipsychotic Agents; D012110:Reserpine; D002374:Catalase; D005978:Glutathione