Placental p,p'-dichlorodiphenyldichloroethylene and cord blood immune markers.
Placental p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentration and cord blood atopic markers were determined in 19 neonates. Increased placental p,p'-DDE was associated with a statistically significant increase in cord plasma interleukin (IL)-13. Furthermore, both cord plasma IL-4/interferon (IFN)-gamma and IL-13/IFN-gamma ratios were significantly positively associated with placental p,p'-DDE concentration.
Brooks
Kevin
K
Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, SC 29208-0001, USA.
Hasan
Hanem
H
Samineni
Sridhar
S
Gangur
Venu
V
Karmaus
Wilfried
W
D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D001769:Blood / Q000276:immunology*; D001774:Blood Chemical Analysis; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis* / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D018793:Interleukin-13 / Q000097:blood / Q000276:immunology; D015847:Interleukin-4 / Q000097:blood / Q000276:immunology; D010920:Placenta / Q000737:chemistry / Q000276:immunology*; D011247:Pregnancy
D015415:Biomarkers; D018793:Interleukin-13; D015847:Interleukin-4; D003633:Dichlorodiphenyl Dichloroethylene; D007371:Interferon-gamma