title: Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
abstract: A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.
authors.affiliation: Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK.
authors.forename: Jeffery J
authors.initials: JJ
authors.lastname: Newsome
authors.forename: Marie A
authors.initials: MA
authors.lastname: Colucci
authors.forename: Mary
authors.initials: M
authors.lastname: Hassani
authors.forename: Howard D
authors.initials: HD
authors.lastname: Beall
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Moody
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D001562:Benzimidazoles; D052160:Benzothiazoles; D011809:Quinones; D011994:Recombinant Proteins; C031000:benzimidazole; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; C005465:benzothiazole