123I MIBG mapping with intraoperative gamma probe for recurrent neuroblastoma.
Intraoperative gamma probe guidance has become widely utilized for sentinel lymph node dissection in patients with breast cancer and melanoma, using (99m)Tc sulfur colloid. However, new indications are possible and need to continue to be investigated. We report the use during a wedge liver biopsy of a new hand-held gamma probe designed for (123)I intraoperative guidance. The patient studied is a 5-year-old boy with history of stage 4 high-risk neuroblastoma. Anatomic imaging (CT, MRI), (99m)Tc bone scintigraphy and 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) were negative, but the (123)I MIBG scintigraphy suggested recurrent liver disease. A decision was made to biopsy these lesions to obtain histopathological confirmation. Intraoperative gamma probe mapping of the liver identified areas with signal above the background, but these were prove to be hemosiderin deposits on histo-pathology examination.
Iagaru
Andrei
A
Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, Stanford, CA 94305-5427, USA.
Peterson
David
D
Quon
Andrew
A
Dutta
Sanjeev
S
Twist
Claire
C
Daghighian
Farhdad
F
Gambhir
Sanjiv Sam
SS
Albanese
Craig
C
D019797:3-Iodobenzylguanidine; D002675:Child, Preschool; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007430:Intraoperative Care; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009447:Neuroblastoma / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine