title: An extranodal nasal natural killer/T-cell lymphoma with isochromosome 7q10 as the sole cytogenetic aberration was initially diagnosed via bone marrow biopsy.
abstract: We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and "sinusitis" of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+ (dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus- encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of his right nasal vestibule demonstrated an atypical lymphoid infiltrate, which was cytoplasmic CD3+, CD56+, and Epstein-Barr virus-encoded RNA positive, consistent with an extranodal nasal natural killer cell lymphoma. Conventional cytogenetic studies of the bone marrow revealed isochromosome 7q10 [i(7)(q10)] as the sole chromosomal aberration. To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9073, USA. huan-you.wang@utsouthwestern.edu
authors.forename: Huan-You
authors.initials: HY
authors.lastname: Wang
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Wilson
authors.forename: Robert W
authors.initials: RW
authors.lastname: McKenna
authors.forename: Yin
authors.initials: Y
authors.lastname: Xu
authors.forename: Nitin
authors.initials: N
authors.lastname: Karandikar
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D003937:Diagnosis, Differential; D006801:Humans; D018404:Isochromosomes / Q000235:genetics*; D007694:Killer Cells, Natural / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology