Aquaporin-related disorders of water homeostasis.
The discovery of four major water channels in the kidney, namely aquaporins (AQP) 1, 2, 3 and 4, has allowed a substantial increase in our understanding of renal water regulation in health and disease. This review discusses the renal aquaporin water channels in the urinary dilution and concentrating defects in cardiac failure, cirrhosis, syndrome of inappropriate hormone secretion, pregnancy, hypothyroidism, isolated glucocorticoid deficiency, isolated mineralocorticoid deficiency, primary polydipsia, acquired and genetic nephrogenic diabetes insipidus.
Schrier
Robert W
RW
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA. Robert.schrier@uchsc.edu
D000818:Animals; D020346:Aquaporins / Q000378:metabolism / Q000502:physiology; D001834:Body Water / Q000378:metabolism*; D018500:Diabetes Insipidus, Nephrogenic / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005355:Fibrosis / Q000097:blood / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011247:Pregnancy; D014883:Water-Electrolyte Imbalance / Q000378:metabolism*
D020346:Aquaporins