title: A tissue-level model of the left ventricle for the analysis of regional myocardial function.
abstract: This paper presents a model-based method for the analysis of regional myocardial strain, based on echocardiography and Tissue Doppler Imaging (TDI). A multi-formalism, tissue-level electromechanical model of the left ventricle is proposed. The parameters of the model are identified in order to reproduce regional strain signal morphologies obtained from a healthy subject and a patient presenting a dilated cardiomyopathy. The parameters identified for the DCM patient allow the localization of the failing myocardial segments and may be useful for a better design of cardiac resynchronization therapy on heart failure patients.
authors.affiliation: INSERM U642, Rennes, Université de Rennes 1, LTSI, Rennes, F35000, France. virginie.lerolle@univ-rennes1.fr
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Richard
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
authors.forename: Guy
authors.initials: G
authors.lastname: Carrault
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004452:Echocardiography / Q000379:methods*; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*