[Pathogenesis of osteoarthritis--a snapshot].
Osteoarthritis (OA) is a degenerative joint disease of as yet unknown pathology. Combining genome and transcriptome analyses with methods from systems biology helped to identify OA as the result of active disease processes. Here, chondrocytes are of central importance as they seem to undergo increased apoptosis and to shift their metabolism towards cartilage degradation.
Müller-Hilke
B
B
Institut für Immunologie der Medizinischen Fakultät, Universität Rostock, Schillingallee 70, 18055, Rostock, Germany. brigitte.mueller-hilke@med.uni-rostock.de
D017209:Apoptosis / Q000235:genetics; D019902:Chondrocytes / Q000473:pathology; D018450:Disease Progression; D005109:Extracellular Matrix / Q000473:pathology; D020869:Gene Expression Profiling; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D010003:Osteoarthritis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D040901:Proteomics; D012307:Risk Factors
D005819:Genetic Markers