Diverse FSH and testosterone signaling pathways in the Sertoli cell.
FSH and testosterone exert different regulatory effects on the seminiferous epithelium; they act through multiple and complex signaling routes to direct the development of the germ cells into mature spermatozoa. In addition to their well-known pathways of action, both hormones have recently been recognized to have new signaling routes that are linked to the Ca(2+) ion, including, among others, the regulation of cell proliferation by FSH and the regulation of cell migration by testosterone.
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Departamento de Fisiologia, ICBS, UFRGS, Porto Alegre, RS, Brazil.
Jacobus
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Wassermann
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GF
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006801:Humans; D008297:Male; D015290:Second Messenger Systems / Q000502:physiology*; D012708:Sertoli Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013739:Testosterone / Q000502:physiology*
D013739:Testosterone; D005640:Follicle Stimulating Hormone