Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth.
BACKGROUND
Few studies have examined the relation between dietary carbohydrate quality, adiposity, and insulin dynamics in children.


OBJECTIVE
The objective of the study was to determine which aspects of dietary carbohydrate, specifically dietary sugar, fiber, glycemic index, or glycemic load, are associated with adiposity and insulin dynamics in overweight Latino children.


METHODS
We examined 120 overweight Latino children (10-17 y old) with a family history of type 2 diabetes. Dietary intake was determined by repeated 24-h diet recalls. Adiposity was assessed by using total-body dual-energy X-ray absorptiometry. Insulin dynamics [insulin sensitivity (SI), acute insulin response, and disposition index (an index of beta-cell function)] were measured by using a frequently sampled intravenous-glucose-tolerance test.


RESULTS
After adjustment for covariates, total sugar (g/d) was positively correlated with body mass index (BMI; in kg/m(2)), BMI z scores, and total fat mass (r = 0.20, r = 0.22, and r = 21, respectively; P < 0.05) and negatively correlated with SI and disposition index (r = -0.29 and r = -0.24, respectively; P < 0.05). Dietary fiber, glycemic index, and glycemic load were not significantly correlated with adiposity or insulin dynamics before or after control for covariates. Regression analyses showed that total sugar intake explained an additional 3.4%, 4.6%, and 2.4% of the variance in BMI, BMI z scores, and total fat mass, respectively, and an additional 5.6% and 4.8% of the variance in SI and disposition index (P < 0.05), respectively, after control for covariates.


CONCLUSIONS
In this cohort, total sugar intake, rather than glycemic index or glycemic load, was associated with higher adiposity measures, lower SI, and lower measures of insulin secretion.
Davis
Jaimie N
JN
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. jaimieda@usc.edu
Alexander
Katharine E
KE
Ventura
Emily E
EE
Kelly
Louise A
LA
Lane
Christianne J
CJ
Byrd-Williams
Courtney E
CE
Toledo-Corral
Claudia M
CM
Roberts
Chris K
CK
Spruijt-Metz
Donna
D
Weigensberg
Marc J
MJ
Goran
Michael I
MI
D050154:Adiposity; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005260:Female; D038321:Glycemic Index; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000378:metabolism*
D004040:Dietary Carbohydrates