[Epithelioid schwannoma of the colon. Report of two cases].
Schwannomas of the colon are rare tumors. Most of them are spindle cell tumors. The epithelioid variant is exceedingly rare with only 10 cases reported in the literature. We report two fortuitously discovered cases in 37 and 42-year-old women. The masses were located in the sigmoid and the right colon. They measured 2,5 and 3 cm in diameter. On microscopic examination, they were composed of sheets of uniform epithelioid cells without atypia or mitosis. One of them had a cuff of benign lymphoid hyperplasia. Immunohistochemical study showed positive staining of the tumor cells for S100 protein and some of them for glial fibrillary acidic protein. Some CD34-positive fibroblast-like cells were identified in the two tumors. There was no recurrence with a follow-up ranging from 6 to 24 months. Epithelioid schwannoma of the colon is a benign tumor of uncertain histogenesis which may be confused with more aggressive neoplasms.
Ples
Raluca
R
Service d'Anatomie Pathologique, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex.
Lazure
Thierry
T
Dimet
Stéphanie
S
Lascar
Gilles
G
Sales
Jean-Patrick
JP
Moulin
Gilles
G
Ladouch-Badre
Aliette
A
Guettier
Catherine
C
D000328:Adult; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008938:Mitosis; D008940:Mitotic Index; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000601:surgery; D009442:Neurilemmoma / Q000473:pathology* / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
D005904:Glial Fibrillary Acidic Protein