title: Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas.
abstract: OBJECTIVE
  To investigate serum levels of glial fibrillary acidic protein (GFAP) and S-100B in patients with newly diagnosed high-grade gliomas.
  
  
  METHODS
  GFAP and S-100B were measured by enzyme-linked immunosorbent assay techniques in preoperative serum from 31 patients with high-grade gliomas. A database with clinical, radiological and histological variables was created for statistical analyses.
  
  
  RESULTS
  Mean serum levels of 239 ng/l (range 30-1210 ng/l) for GFAP and 58.3 ng/l (range 22-128 ng/l) for S-100B were found. Of the 31 patients, 16 had elevated levels of GFAP while only two showed increased S-100B concentrations. Tumour size was the only variable significantly associated with serum levels of GFAP (P < 0.0001) with a linear correlation coefficient of 0.67.
  
  
  CONCLUSIONS
  Serum levels of GFAP demonstrated a linear correlation to tumour volume in patients with high-grade gliomas. GFAP seems to be a more reliable biomarker in patients with high-grade gliomas than the commercially available S-100B.
authors.affiliation: Neurosurgical Department, University Hospital of North Norway, Tromsø, Norway. tor.brommeland@unn.no
authors.forename: T
authors.initials: T
authors.lastname: Brommeland
authors.forename: L
authors.initials: L
authors.lastname: Rosengren
authors.forename: S
authors.initials: S
authors.lastname: Fridlund
authors.forename: R
authors.initials: R
authors.lastname: Hennig
authors.forename: V
authors.initials: V
authors.lastname: Isaksen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood*; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D049109:Cell Proliferation; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D005910:Glioma / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009414:Nerve Growth Factors / Q000032:analysis / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000097:blood; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins