A novel functional translocator protein ligand for cancer imaging.
The translocator protein (TSPO) is an attractive target for tumor imaging due to its up-regulation in numerous cancer cell types. Here, we report a series of functional TSPO ligands, n-TSPOmbb732, which can be conjugated to a variety of signaling moieties and are widely applicable in TSPO-targeted molecular imaging. Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro.
Bai
Mingfeng
M
Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, TN 37235-1822, USA.
Rone
Malena B
MB
Papadopoulos
Vassilios
V
Bornhop
Darryl J
DJ
D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009369:Neoplasms / Q000378:metabolism*; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D011506:Proteins