Re-modelling 'hostile' milieu of diseased myocardium via paracrine function of transplanted cells or relaxin.
While the approaches of regenerating cardiac muscle remain undetermined, recent evidence indicates that paracrine function of transplanted cells contributes significantly to the beneficial effects of cell therapy. Combination of such paracrine function of grafted cells with extracellular matrix remodelling by relaxin represents a promising complement to cell-based therapy for cardiac repair and muscle regeneration.
Du
Xiao-Jun
XJ
Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Australia. xiaojun.du@baker.edu.au
D000818:Animals; D017690:Cell Transplantation; D051379:Mice; D032446:Myoblasts / Q000637:transplantation*; D009206:Myocardium / Q000473:pathology*; D019899:Paracrine Communication; D012065:Relaxin / Q000378:metabolism*; D020257:Ventricular Remodeling / Q000502:physiology*
D012065:Relaxin