Role of mast cells in tumor growth.
The growth of malignant tumors is determined in large part by the proliferative capacity of the tumor cells. Clinical observations and animal experiments have established that tumor cells elicit immune responses. Histopathologic studies show that many tumors are surrounded by mononuclear cell and mast cell infiltrates. Mast cells are ubiquitous in the body and are critical for allergic reactions. Increasing evidence indicates that mast cells secrete proinflammatory cytokines and are involved in neuro-inflammatory processes and cancer. Mast cells accumulate in the stroma surrounding certain tumors, especially mammary adenocarcinoma, and the molecules they secrete can benefit the tumor. However, mast cells can also increase at the site of tumor growth and participate in tumor rejection. Mast cells may be recruited by tumor-derived chemoattractants and selectively secrete molecules such as growth factors, histamine, heparin, VEGF, and IL-8, as well as proteases that permit the formation of new blood vessels and metastases. Tumor mast cell intersections play regulatory and modulatory roles affecting various aspects of tumor growth. Discovery of these new roles of mast cells further complicates the understanding of tumor growth. This review focuses on the strategic importance of mast cells to the progression of tumors, and proposes a revised immune effector mechanism of mast cell involvement in tumor growth.
Conti
Pio
P
Immunology Division, Department of Oncology and Neuro-science, University of Chieti, Via dei Vestini, 66100 Chieti, Italy.
Castellani
Maria L
ML
Kempuraj
Durasamy
D
Salini
Vincenzo
V
Vecchiet
Jacopo
J
Tetè
Stefano
S
Mastrangelo
Filiberto
F
Perrella
Alessandro
A
De Lutiis
Maria Anna
MA
Tagen
Michael
M
Theoharides
Theoharis C
TC
D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006801:Humans; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000276:immunology
D016207:Cytokines; D006632:Histamine