Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics.
We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin) using cyclic voltammetry. The antioxidant properties of these compounds were also studied. A structural analysis of the tested phenolics suggests that multiple OH substitution and conjugation are important determinants of the free radical scavenging activity and electrochemical behavior. Compounds with low oxidation potentials (Epa lower than 0.45) showed antioxidant activity, whereas compounds with high Epa values (>0.45) act as prooxidants.
Simić
Aleksandra
A
Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia. simic@chem.bg.ac.yu
Manojlović
Dragan
D
Segan
Dejan
D
Todorović
Marija
M
D000975:Antioxidants / Q000737:chemistry*; D002109:Caffeic Acids / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry; D004563:Electrochemistry; D016166:Free Radical Scavengers / Q000737:chemistry; D062385:Hydroxybenzoates / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry*; D012431:Rutin / Q000737:chemistry; D020156:Salicylic Acid / Q000737:chemistry
D000975:Antioxidants; D002109:Caffeic Acids; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D062385:Hydroxybenzoates; D010636:Phenols; D017382:Reactive Oxygen Species; C009091:protocatechuic acid; D012431:Rutin; D011794:Quercetin; D020156:Salicylic Acid; C040048:caffeic acid