title: Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.
abstract: To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
authors.affiliation: Department of Neuropathology, University Hospital of Cologne, Cologne, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Montesinos-Rongen
authors.forename: A
authors.initials: A
authors.lastname: Brunn
authors.forename: S
authors.initials: S
authors.lastname: Bentink
authors.forename: K
authors.initials: K
authors.lastname: Basso
authors.forename: W K
authors.initials: WK
authors.lastname: Lim
authors.forename: W
authors.initials: W
authors.lastname: Klapper
authors.forename: C
authors.initials: C
authors.lastname: Schaller
authors.forename: G
authors.initials: G
authors.lastname: Reifenberger
authors.forename: J
authors.initials: J
authors.lastname: Rubenstein
authors.forename: O D
authors.initials: OD
authors.lastname: Wiestler
authors.forename: R
authors.initials: R
authors.lastname: Spang
authors.forename: R
authors.initials: R
authors.lastname: Dalla-Favera
authors.forename: R
authors.initials: R
authors.lastname: Siebert
authors.forename: M
authors.initials: M
authors.lastname: Deckert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D018858:Germinal Center / Q000473:pathology*; D006801:Humans; D007121:Immunocompetence; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged