Restricting the ligation step of non-homologous end-joining.
Non-homologous end-joining is an important pathway for repairing DNA double-strand breaks. The budding yeast Saccharomyces cerevisiae possesses two proteins, Nej1/Lif2 and Ntr1/Spp382, which play a role in restricting the activity of Dnl4-Lif1, the complex that executes the final ligation step of this process.
Chovanec
Miroslav
M
Laboratory of Molecular Genetics, Cancer Research Institute, Vlárska 7, 833 91 Bratislava 37, Slovak Republic.
Wilson
Thomas E
TE
D004260:DNA Repair; D004271:DNA, Fungal / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004271:DNA, Fungal