title: Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta-analysis.
abstract: BACKGROUND
  The risk of deep vein thrombosis (DVT) is increased in cancer patients with central venous catheters (CVC). Factor (F)V Leiden and the G20210A prothrombin mutation (PTM) may play a role in causing catheter-related DVT in patients with cancer. However, information on the association between these thrombophilic abnormalities and CVC-related thrombosis are scarce.
  
  
  OBJECTIVE
  To assess the risk of CVC-related thrombosis associated with these two thrombophilic disorders.
  
  
  METHODS
  MEDLINE and EMBASE databases (up to March 2007); reference lists of retrieved articles. Studies comparing the prevalence of prothrombotic abnormalities in cancer patients with CVC-related thrombosis and in a control group of cancer subjects with CVC without thrombosis. Two reviewers independently selected studies and extracted study characteristics, quality and outcomes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each trial and pooled.
  
  
  RESULTS
  Ten studies involving 1000 patients were included. The pooled OR for CVC-related thrombosis was 4.6 (95% CI: 2.6, 8.1) in patients with FV Leiden. The pooled OR for CVC-related thrombosis was 4.9 (95% CI: 1.7, 14.3) in patients with PTM. The estimated attributable risk of CVC-related thrombosis was 13.1% for FV Leiden and 4.5% for PTM.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that the presence of FV Leiden and PTM is associated with CVC-related thrombosis.
authors.affiliation: Department of Clinical Medicine, University of Insubria, Varese, Italy. fdentali@libero.it
authors.forename: F
authors.initials: F
authors.lastname: Dentali
authors.forename: M
authors.initials: M
authors.lastname: Gianni
authors.forename: G
authors.initials: G
authors.lastname: Agnelli
authors.forename: W
authors.initials: W
authors.lastname: Ageno
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005165:Factor V / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D016017:Odds Ratio; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000235:genetics*; D013927:Thrombosis / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin