title: The BioGRID Interaction Database: 2008 update.
abstract: The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.forename: Michael
authors.initials: M
authors.lastname: Livstone
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Lackner
authors.forename: Jürg
authors.initials: J
authors.lastname: Bähler
authors.forename: Valerie
authors.initials: V
authors.lastname: Wood
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D003628:Database Management Systems; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D051379:Mice; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism; D014584:User-Computer Interface
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins