title: An in computo investigation of the Landau-Kleffner syndrome.
abstract: We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
authors.affiliation: Cyclotron Medical Research Center, School of Medicine, University of Liege, 4000 Liege, Belgium. m.bonjean@ulg.ac.be
authors.forename: Maxime
authors.initials: M
authors.lastname: Bonjean
authors.forename: Christophe
authors.initials: C
authors.lastname: Phillips
authors.forename: Thien Thanh Dang
authors.initials: TT
authors.lastname: Vu
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Sepulchre
authors.forename: Pierre
authors.initials: P
authors.lastname: Maquet
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology; D003198:Computer Simulation; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology