title: Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment.
abstract: Interleukin (IL)-17 is a key inflammatory cytokine in autoimmune disease and may play an important role in the development of experimental autoimmune encephalomyelitis (EAE). In this study, we observed decreased IL-17 and increased IL-27 in EAE rats treated with bone marrow stromal cells (BMSCs). Neutralization of IL-27 resulted in recovery of the BMSCs effect. Adoptive transfer induction of EAE was poor by BMSC-stimulated MNCs, but could be induced by MNCs stimulated by BMSCs under blockade of IL-27 signaling. These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation.
authors.affiliation: Department of Neurobiology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang 150081, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Wang
authors.forename: Guangyou
authors.initials: G
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Hulun
authors.initials: H
authors.lastname: Li
authors.forename: Lili
authors.initials: L
authors.lastname: Mu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Guozhong
authors.initials: G
authors.lastname: Li
authors.forename: Lijun
authors.initials: L
authors.lastname: Shi
authors.forename: Lianhong
authors.initials: L
authors.lastname: Jin
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kostulas
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D016207:Cytokines / Q000096:biosynthesis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism* / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016219:Immunotherapy, Adoptive; D020381:Interleukin-17 / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D017154:Stromal Cells / Q000637:transplantation*
chemical_list: D016207:Cytokines; D020381:Interleukin-17