title: Post-chemiluminescence phenomenon of NBS-luminol reactions and their applications to flow injection analysis of piroxicam.
abstract: A new post-chemiluminescence (PCL) reaction was observed when piroxicam was injected into the reaction mixture after the CL reaction of N-bromosuccinimide (NBS) and luminol. A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics, the CL spectra, fluorescence spectra and other experiments. A new flow injection CL method for the determination of piroxicam was established based on the PCL reaction. The relative standard deviation (RSD) for the determination of piroxicam was 1.2% (n = 11, c = 2.0 x 10(-6) g/ml). The CL intensity responded linearly to the concentration of piroxicam in the range 1.0 x 10(-7) - 1.0 x 10(-5) g/ml (r = 0.9991). The detection limit was 4.0 x 10(-8) g/ml. The method had been applied to the determination of piroxicam in tablets with satisfactory results.
authors.affiliation: School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Bai
authors.forename: Fei
authors.initials: F
authors.lastname: Nie
authors.forename: Jiuru
authors.initials: J
authors.lastname: Lu