title: [Comparative study between two different sources of n-3 poliunsaturated fatty acids and it effect on thymus and lipid profile in rats].
abstract: In the present paper we analyzed the effect caused by different recovery diets enriched with n-3 polyunsaturated fatty acids (PUFA n-3) on thymus and serum lipid pattern. Severe depleted weanling Wistar rats (D) were divided in three groups that received during 10 days a 20% casein diet supplemented with EPA+DHA (group Cas), a 20% protein milk diet prepared using a commercial reduced-fat product enriched with linolenic and linoleic acids (group L) and a 20% casein diet as control group C. Cas and L gave each other 24 mg/day of PUFA n-3 being the ratio n-6/n-3 8.1/1 and 7.6/1, respectively. Thymus was removed and weighted and cell number were determined; blood was recollected and Total cholesterol, triacylglycerol, HDL and LDL-cholesterol fractions and myristic, palmitic, stearic, oleic, linoleic, linolenic, araquidonic, EPA and DHA fatty acid concentrations were measured in serum. Statistical analysis was performed using Anova test. Cell number were higher (p<0.01) in Cas (44.48+/-8.20) and in L (56.45+/-14.72) when compared to group D (1.80+/-0.70) and group C (23.70+/-4.04). L presented lower values of cholesterol, HDL and LDL-cholesterol (p<0.01) and higher values of triacylglycerol (p<0.05) when compared to Cas, being EPA (p<0.05) and DHA (p<0.01) higher in Cas. Being PUFA n-3 contribution the same in Cas and L, both diets were able to reverse the thymic athropy presenting a different hipolipemic behavior due to the different sources of PUFA n-3 used in the diets.
authors.affiliation: Laboratorio de Nutrición Experimental, Cátedra de Nutrición, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: Inés
authors.initials: I
authors.lastname: Fernandez
authors.forename: Anabel N
authors.initials: AN
authors.lastname: Pallaro
authors.forename: Nora H
authors.initials: NH
authors.lastname: Slobodianik
mesh_terms: D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D009929:Organ Size / Q000187:drug effects; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000178:diet therapy*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology
chemical_list: D015525:Fatty Acids, Omega-3; D008055:Lipids