title: Gene Ontology annotations at SGD: new data sources and annotation methods.
abstract: The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) collects and organizes biological information about the chromosomal features and gene products of the budding yeast Saccharomyces cerevisiae. Although published data from traditional experimental methods are the primary sources of evidence supporting Gene Ontology (GO) annotations for a gene product, high-throughput experiments and computational predictions can also provide valuable insights in the absence of an extensive body of literature. Therefore, GO annotations available at SGD now include high-throughput data as well as computational predictions provided by the GO Annotation Project (GOA UniProt; http://www.ebi.ac.uk/GOA/). Because the annotation method used to assign GO annotations varies by data source, GO resources at SGD have been modified to distinguish data sources and annotation methods. In addition to providing information for genes that have not been experimentally characterized, GO annotations from independent sources can be compared to those made by SGD to help keep the literature-based GO annotations current.
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA, USA.
authors.forename: Eurie L
authors.initials: EL
authors.lastname: Hong
authors.forename: Rama
authors.initials: R
authors.lastname: Balakrishnan
authors.forename: Qing
authors.initials: Q
authors.lastname: Dong
authors.forename: Karen R
authors.initials: KR
authors.lastname: Christie
authors.forename: Julie
authors.initials: J
authors.lastname: Park
authors.forename: Gail
authors.initials: G
authors.lastname: Binkley
authors.forename: Maria C
authors.initials: MC
authors.lastname: Costanzo
authors.forename: Selina S
authors.initials: SS
authors.lastname: Dwight
authors.forename: Stacia R
authors.initials: SR
authors.lastname: Engel
authors.forename: Dianna G
authors.initials: DG
authors.lastname: Fisk
authors.forename: Jodi E
authors.initials: JE
authors.lastname: Hirschman
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Hitz
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Krieger
authors.forename: Michael S
authors.initials: MS
authors.lastname: Livstone
authors.forename: Stuart R
authors.initials: SR
authors.lastname: Miyasato
authors.forename: Robert S
authors.initials: RS
authors.lastname: Nash
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.forename: Marek S
authors.initials: MS
authors.lastname: Skrzypek
authors.forename: Shuai
authors.initials: S
authors.lastname: Weng
authors.forename: Edith D
authors.initials: ED
authors.lastname: Wong
authors.forename: Kathy K
authors.initials: KK
authors.lastname: Zhu
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.forename: David
authors.initials: D
authors.lastname: Botstein
authors.forename: J Michael
authors.initials: JM
authors.lastname: Cherry
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D005800:Genes, Fungal; D016681:Genome, Fungal; D023281:Genomics; D020407:Internet; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D014584:User-Computer Interface; D018875:Vocabulary, Controlled
chemical_list: D029701:Saccharomyces cerevisiae Proteins