["... The better to see you with"--phothodynamic diagnostic in superficial bladder cancer].
Fluorescence cystoscopy of the urinary bladder allows to better identify tumors and altered bladder mucosa (e.g. Carcinoma in situ). Instillation of 5-aminolevulinic acid or hexyl aminolevulinate approx. two hours before transurethral resection leads to metabolism of these compounds in the Häm-biosynthesis and to accumulation of protoporphyrin IX (PPIX). PPIX is an excellent fluorochrom, which lights up red when illuminated by blue light. During transurethral resection all tumors and all suspicious mucosal areas can be completely resected. As a consequence recurrence rate drops and patients need less re-operations and hospitalizations.
Forster
T H
TH
Urologische Universitätsklinik beider Basel.
Wyler
S
S
Ruszat
R
R
Gasser
T C
TC
Bachmann
A
A
D000283:Administration, Intravesical; D000622:Aminolevulinic Acid / Q000008:administration & dosage; D000818:Animals; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000601:surgery; D017326:Clinical Trials, Phase III as Topic; D003558:Cystoscopy / Q000379:methods*; D004195:Disease Models, Animal; D005453:Fluorescence; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011446:Prospective Studies; D011524:Protoporphyrins; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D012086:Reoperation; D012680:Sensitivity and Specificity; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000601:surgery
D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX