Somatostatinergic systems in brain: networks and functions.
Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-coupled receptor family. Recent advances in the neuroanatomy of somatostatin neurons and cellular distribution of sst receptors shed light on their functional roles in the neuronal network. Beside their initially described neuroendocrine role, somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer's disease.
Viollet
Cécile
C
Inserm, UMR 549, Paris, France.
Lepousez
Gabriel
G
Loudes
Catherine
C
Videau
Catherine
C
Simon
Axelle
A
Epelbaum
Jacques
J
D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism; D006801:Humans; D019964:Mood Disorders / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000502:physiology*; D055503:Protein Multimerization; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D017481:Receptors, Somatostatin / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction; D013004:Somatostatin / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism
D018377:Neurotransmitter Agents; D043562:Receptors, G-Protein-Coupled; D017481:Receptors, Somatostatin; D013004:Somatostatin