title: [Protein glycation and endothelium dysfunction].
abstract: Advanced glycation end-products (AGE) are a group of heterogeneous molecules found in higher levels during diabetes, end stage renal failure and aging. Vascular alteration is correlated with their accumulation as during retinopathy or glomerulosclerosis. Glycation of extracellular matrix proteins is associated with diabetic angiopathy. AGE stimulate endothelial cell via the interaction with the receptor RAGE, leading to an inflammatory state with increased adhesion molecule expression, chemoattractant factor and tissue factor production. RAGE activation by AGE triggers reactive oxygen species production by NADPH oxydase. Agents that inhibit AGE formation, stimulate their degradation or neutralize their binding to RAGE represent new approaches to limit the deleterious activities of AGE.
authors.affiliation: Laboratoire de Biologie Vasculaire et Cellulaire, Institut National Transfusion Sanguine, Paris.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Grossin
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Wautier
mesh_terms: D000375:Aging / Q000502:physiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology
chemical_list: D016326:Extracellular Matrix Proteins; D017127:Glycation End Products, Advanced