Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole.
Low grade endometrial stromal sarcoma (LGESS) is a rare disease. LGESS usually expresses steroidal receptors and is regarded to be hormone-sensitive. Due to the rarity of the tumor, only few case series have been published so far. Here, we report the case of a 36-year-old woman who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy for a G1 LGESS in 1991. Twelve years later she presented to us with pelvic and peritoneal masses. The patient was treated with letrozole achieving a partial response which is lasting 39 months. Treatment is ongoing. Aromatase inhibitors represent an interesting treatment option for LGESS.
Krauss
K
K
Department of Obstetrics and Gynecology, Eberhard-Karls-University Tuebingen, Calwestr. 7, D-72076 Tuebingen, Germany.
Bachmann
C
C
Hartmann
J T
JT
Siegmann
K
K
Sotlar
K
K
Wallwiener
D
D
Huober
J
J
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D036821:Endometrial Stromal Tumors / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D000077289:Letrozole; D019042:Muscle Neoplasms / Q000556:secondary; D009570:Nitriles / Q000627:therapeutic use*; D016658:Psoas Muscles / Q000473:pathology; D011860:Radiography, Abdominal; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole