title: [Bisphosphonate-associated osteonecrosis of the jaws. 3. Two case reports].
abstract: The cases presented show that bisphosphonate-induced osteonecrosis of the jaw is difficult to treat. Recently, a classification of bisphosphonate-induced osteonecrosis of the jaw based on clinical appearance was published. On the basis of this classification the seriousness of the osteonecrosis can be evaluated and a method of treatment determined. The common opinion is that treatment should be as conservative as possible. This means that treatment should have as its objective the prevention of the spread of the disease by means of antibiotics and disinfectant mouthwash. Sharp bony edges may be trimmed. Extensive surgical treatment should be reserved for those rare cases in which the osteonecrosis is progressive.
authors.affiliation: Afdeling Kaakchirurgie van het Universitair Medisch Centrum Groningen.
authors.forename: J
authors.initials: J
authors.lastname: Schortinghuis
authors.forename: L
authors.initials: L
authors.lastname: Meijndert
authors.forename: J G A M
authors.initials: JG
authors.lastname: de Visscher
authors.forename: M J H
authors.initials: MJ
authors.lastname: Witjes
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000517:prevention & control / Q000601:surgery; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced* / Q000517:prevention & control / Q000601:surgery
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates