title: Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1.
abstract: The limited coding capacity of retroviral genomes forces these viruses to rely heavily on the host-cell machinery for their replication. This phenomenon is particularly well illustrated by the interaction between retroviruses and components of the endosomal budding machinery that occurs during virus release. Here, we focus on the use of host-cell factors during HIV-1 budding and highlight recent progress in our understanding of the role of one such factor, Alix, in both viral and cellular membrane budding and fission events.
authors.affiliation: Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Fujii
authors.forename: James H
authors.initials: JH
authors.lastname: Hurley
authors.forename: Eric O
authors.initials: EO
authors.lastname: Freed
mesh_terms: D002462:Cell Membrane / Q000821:virology; D004268:DNA-Binding Proteins / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000276:immunology*; D015683:Gene Products, gag / Q000502:physiology; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D014157:Transcription Factors / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology; D000099177:Tsg101 Protein
chemical_list: D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; D014157:Transcription Factors; D000099177:Tsg101 Protein