Method for assessing the similarity between subsets of the T cell receptor repertoire.
The CD8+ T cell response is important in the control of many viral and other infections. There have been many studies aimed at better understanding the influence of T cell receptor diversity on immune responses and the evolution of the T cell receptor repertoire over time and through the various stages of immune responses to infection. In recent years, there has been an increase in both the number of studies using T cell receptor data and the volume of T cell receptor data generated per study. Appropriate analytical tools are required to analyse this data. We present a robust approach to assessing the similarity between samples of the T cell receptor repertoire, which we demonstrate on published data of subsets of the influenza A virus D(b)NP366(-) and D(b)PA224(-)specific CD8+ T cell responses in mice sorted on the expression of CD62L, which is a marker distinguishing central and effector memory cells.
Venturi
Vanessa
V
Department of Haematology, Prince of Wales Hospital, Kensington NSW 2052, Australia. v.venturi@unsw.edu.au
Kedzierska
Katherine
K
Tanaka
Mark M
MM
Turner
Stephen J
SJ
Doherty
Peter C
PC
Davenport
Miles P
MP
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D019295:Computational Biology; D004195:Disease Models, Animal; D007156:Immunologic Memory; D009980:Influenza A virus; D019041:L-Selectin / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018448:Models, Immunological; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000821:virology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013997:Time Factors
D011948:Receptors, Antigen, T-Cell; D019041:L-Selectin