title: Association between obesity and cancer incidence in the population of the District Sumperk, Czech Republic.
abstract: BACKGROUND
  Excess body weight was shown to be associated with risk of several types of cancer. In the Czech Republic, malignant tumors are the second leading cause of death. The aim of this study was to assess the association between the most frequent types of cancer and obesity.
  
  
  METHODS
  A case-control study was accomplished, using data from the National Cancer Registry and from a preventive oncologic checkup database. Cases were defined as persons from the studied population who developed skin, breast, colorectal, prostate, lung, cervical, endometrial, kidney, ovarian, urinary bladder, stomach, pancreatic, or gallbladder cancers from 1987 to 2002. Controls were cancer-free men and women from the population. Among the cancer patients and healthy controls, proportions of obese, overweight, and nonobese individuals were compared, and odds ratios (OR) were computed.
  
  
  RESULTS
  After adjustment for confounders, obese men had a significantly increased risk of colorectal cancer (OR: 2.07, 95% CI: 1.56-2.76) and kidney cancer (OR: 1.92, 95% CI: 1.14-3.24). Obese women were at higher risk of endometrial cancer (OR: 3.25, 95% CI: 1.65-6.37). An inverse association was observed between obesity and lung cancer (in men: OR: 0.49, 95% CI: 0.37-0.66; in women: OR: 0.41, 95% CI: 0.21-0.80).
  
  
  CONCLUSIONS
  Obesity is associated with several frequent types of tumors and represents an important preventable cause of cancer in the population of the District Sumperk, Czech Republic.
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine, Palacký University Olomouc, Czech Republic. lmachova@tunw.upol.cz
authors.forename: Lucie
authors.initials: L
authors.lastname: Máchová
authors.forename: Ludek
authors.initials: L
authors.lastname: Cízek
authors.forename: Dagmar
authors.initials: D
authors.lastname: Horáková
authors.forename: Jirina
authors.initials: J
authors.lastname: Koutná
authors.forename: Jirí
authors.initials: J
authors.lastname: Lorenc
authors.forename: Gabriela
authors.initials: G
authors.lastname: Janoutová
authors.forename: Vladimír
authors.initials: V
authors.lastname: Janout
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic