title: Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
abstract: Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 891 biliary (gallbladder or bile duct) stone cases and 786 population controls conducted in Shanghai, China. Compared with subjects carrying the XRCC1 194RR genotype, those with the WW genotype had a 1.9-fold risk of bile duct cancer [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.5, P(trend) = 0.03], and compared with subjects carrying the XRCC1 280RR genotype, those with the XRCC1 280H allele had a 50% reduced risk of bile duct cancer (OR = 0.5, 95% CI = 0.3-0.9, P(trend) = 0.05). The effect of the R280H polymorphism persisted (P(trend) = 0.03), when all three XRCC1 polymorphisms were jointly considered in the model, a finding supported by the haplotype results (covariate-adjusted global permutation P = 0.03). We also found an inverse association between the APEX1 148E allele and gallbladder stones (P(trend) = 0.03), but no association for the OGG1 polymorphism. This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Huang
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Asif
authors.initials: A
authors.lastname: Rashid
authors.forename: Lori C
authors.initials: LC
authors.lastname: Sakoda
authors.forename: Jie
authors.initials: J
authors.lastname: Deng
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Shen
authors.forename: Bin-Sheng
authors.initials: BS
authors.lastname: Wang
authors.forename: Tian-Quan
authors.initials: TQ
authors.lastname: Han
authors.forename: Bai-He
authors.initials: BH
authors.lastname: Zhang
authors.forename: Bingshu E
authors.initials: BE
authors.lastname: Chen
authors.forename: Philip S
authors.initials: PS
authors.lastname: Rosenberg
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
mesh_terms: D001661:Biliary Tract Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair / Q000235:genetics*; D042882:Gallstones / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011159:Population Surveillance