title: Ghrelin and bone.
abstract: A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone. The identity of this peptide has not been elucidated, but ghrelin, produced by A-like cells in the fundus of the stomach, could be a good candidate. Ghrelin stimulates growth hormone (GH) secretion both in vivo and in vitro, and could by this means have a positive effect on bone. There is also evidence for direct effects of ghrelin on bone. We discuss here the role that ghrelin may play in bone metabolism, based on the most recent literature.
authors.affiliation: Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: van der Velde
authors.forename: Patric
authors.initials: P
authors.lastname: Delhanty
authors.forename: Bram
authors.initials: B
authors.lastname: van der Eerden
authors.forename: Aart Jan
authors.initials: AJ
authors.lastname: van der Lely
authors.forename: Johannes
authors.initials: J
authors.lastname: van Leeuwen
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D005743:Gastrectomy / Q000009:adverse effects; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D051381:Rats
chemical_list: D054439:Ghrelin