title: Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
abstract: Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.
authors.affiliation: Department of Fundamental Microbiology, Quartier UNIL-Sorge, Biophore Building, CH-1015 Lausanne, Switzerland.
authors.forename: Marisa
authors.initials: M
authors.lastname: Haenni
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreillon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010403:Penicillin Resistance / Q000235:genetics*; D010406:Penicillins / Q000494:pharmacology*; D012641:Selection, Genetic; D012692:Serial Passage; D054773:Streptococcus gordonii / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins