title: Modelling of a novel x-ray phase contrast imaging technique based on coded apertures.
abstract: X-ray phase contrast imaging is probably the most relevant among emerging x-ray imaging techniques, and it has the proven potential of revolutionizing the field of diagnostic radiology. Impressive images of a wide range of samples have been obtained, mostly at synchrotron radiation facilities. The necessity of relying on synchrotron radiation has prevented to a large extent a widespread diffusion of phase contrast imaging, thus precluding its transfer to clinical practice. A new technique, based on the use of coded apertures, was recently developed at UCL. This technique was demonstrated to provide intense phase contrast signals with conventional x-ray sources and detectors. Unlike other attempts at making phase contrast imaging feasible with conventional sources, the coded-aperture approach does not impose substantial limitations and/or filtering of the radiation beam, and it therefore allows, for the first time, exposures compatible with clinical practice. The technique has been thoroughly modelled, and this paper describes the technique in detail by going through the different steps of the modelling. All the main factors influencing image quality are discussed, alongside the viability of realizing a prototype suitable for clinical use. The model has been experimentally validated and a section of the paper shows the comparison between simulated and experimental results.
authors.affiliation: Department of Medical Physics & Bioengineering, University College London, Malet Place, Gower Street, London WC1E 6BT, UK. aolivio@medphys.ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Olivo
authors.forename: R
authors.initials: R
authors.lastname: Speller
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted; D055095:Optics and Photonics; D017356:Synchrotrons; D014863:Wasps / Q000033:anatomy & histology; D014965:X-Rays