Advances in Bayesian multiple quantitative trait loci mapping in experimental crosses.
Many complex human diseases and traits of biological and/or economic importance are determined by interacting networks of multiple quantitative trait loci (QTL) and environmental factors. Mapping QTL is critical for understanding the genetic basis of complex traits, and for ultimate identification of genes responsible. A variety of sophisticated statistical methods for QTL mapping have been developed. Among these developments, the evolution of Bayesian approaches for multiple QTL mapping over the past decade has been remarkable. Bayesian methods can jointly infer the number of QTL, their genomic positions and their genetic effects. Here, we review recently developed and still developing Bayesian methods and associated computer software for mapping multiple QTL in experimental crosses. We compare and contrast these methods to clearly describe the relationships among different Bayesian methods. We conclude this review by highlighting some areas of future research.
Yi
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Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA. nyi@ms.soph.uab.edu
Shriner
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D001499:Bayes Theorem; D002874:Chromosome Mapping / Q000379:methods*; D003433:Crosses, Genetic; D016013:Likelihood Functions; D015233:Models, Statistical; D040641:Quantitative Trait Loci / Q000235:genetics*; D012984:Software