Hydrogen peroxide is a true first messenger.
Hydrogen peroxide has been shown to act as a second messenger mediating intracellular redox-sensitive signal transduction. Here we show that hydrogen peroxide is also able to transmit pro-inflammatory signals from one cell to the other and that this action can be inhibited by extracellularly added catalase. If these data can be further substantiated, hydrogen peroxide might become as important as nitric oxide as a small molecule intercellular (first) messenger.
Holmquist
L
L
Department of Biochemistry and Molecular Biology, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia.
Stuchbury
G
G
Steele
M
M
Münch
G
G
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D002452:Cell Count; D002460:Cell Line; D002470:Cell Survival / Q000502:physiology; D017127:Glycation End Products, Advanced; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D017628:Microglia / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D019899:Paracrine Communication / Q000502:physiology; D012709:Serum Albumin / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology*; D000093423:Glycated Serum Albumin
D017127:Glycation End Products, Advanced; D008070:Lipopolysaccharides; D009573:Nitrites; D012709:Serum Albumin; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D002374:Catalase; D052247:Nitric Oxide Synthase Type II; D000093423:Glycated Serum Albumin