Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.
Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin-lithium exchange) and is resolved in the presence of a chiral ligand.
Coldham
Iain
I
Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF. i.coldham@sheffield.ac.uk
Patel
Jignesh J
JJ
Raimbault
Sophie
S
Whittaker
David T E
DT
D007700:Kinetics; D008094:Lithium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000302:isolation & purification; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
C454939:N-(tert-butoxycarbonyl)piperidine; D009942:Organometallic Compounds; D010880:Piperidines; D008094:Lithium