Neural stem cell transplantation in a model of fetal alcohol effects.
Neural stem cell (NSC) transplantation has been investigated and developed in areas such as brain injury, stroke and neurodegenerative diseases. Recently, emerging evidence suggest that many of clinical symptoms observed in psychiatric disease are likely related to neural network disruptions including neurogenesis dysfunction. In the present study, we transplanted NSCs into a model of fetal alchol effects (FAE) for the purpose of investigating the possibility of regenerative therapy for the FAE. We labeled NSCs with fluorescent dye and radioisotope which were transplanted into FAE rats by intravenous injection. The transplanted cells were detected in wide areas of brain and were greater in number in the brains of the FAE group compared to the control group. Furthermore NSC transplantation attenuated behavioral abnormalities in FAE animals. These results suggest NSC transplantation as a potental new therapy for human FAE.
Yoshinaga
T
T
Department of Neuropsychiatry, Sapporo Medical University, Sapporo, S-1, W-16, Chuo-ku 060-8543, Japan.
Hashimoto
E
E
Ukai
W
W
Toki
S
S
Saito
S
S
Saito
T
T
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000473:pathology / Q000637:transplantation*; D005106:Exploratory Behavior / Q000502:physiology; D005239:Fear / Q000502:physiology; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007275:Injections, Intravenous; D018782:Maze Learning / Q000502:physiology; D008856:Microscopy, Fluorescence; D009046:Motor Neurons / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar