title: Inhibitors of osteoclast differentiation from Cephalotaxus koreana.
abstract: Three new flavonoid glycosides ( 1- 3), 11-hydroxyhainanolidol ( 4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-beta-D-glucopyranoside ( 3), apigenin ( 6), kaempferol 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 7), tamarixetin 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 8), quercetin 3-O-[6''-O-acetyl]-beta-D-glucopyranoside ( 9), and quercetin 3-O-alpha-L-rhamnopyranoside ( 10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 microg/mL.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
authors.forename: Kee Dong
authors.initials: KD
authors.lastname: Yoon
authors.forename: Doc Gyun
authors.initials: DG
authors.lastname: Jeong
authors.forename: Yun Ha
authors.initials: YH
authors.lastname: Hwang
authors.forename: Jei Man
authors.initials: JM
authors.lastname: Ryu
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D032483:Cephalotaxus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides; D007723:Korea; D015394:Molecular Structure; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C527021:6-methylaromadendrin 3-O-beta-glucopyranoside; D005419:Flavonoids; D005960:Glucosides; D006027:Glycosides; C527023:apigenin 5-O-rhamnopyranosyl(1''''2'')(6''-O-acetyl)glucopyranoside; C527022:isoscutellarein 5-O-beta-glucopyranoside