title: Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture.
abstract: Single walled carbon nanotubes (SWCNT) find their way in various industrial applications. Due to the expected increased production of various carbon nanotubes and nanoparticle containing products, exposure to engineered nanoparticles will also increase dramatically in parallel. In this study the effects of SWCNT raw material and purified SWCNT (SWCNT bundles) on cell behaviour of mesothelioma cells (MSTO-211H) and on epithelial cells (A549) had been investigated. The effect on cell behaviour (cell proliferation, cell activity, cytoskeleton organization, apoptosis and cell adhesion) were dependent on cell type, SWCNT quality (purified or not) and SWCNT concentration.
authors.affiliation: Materials - Biology Interactions Laboratory, Materials Science and Technology (Empa), Lerchenfeldstrasse 5, St. Gallen CH-9014, Switzerland. jean-pierre.kaiser@empa.ch
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Kaiser
authors.forename: Peter
authors.initials: P
authors.lastname: Wick
authors.forename: Pius
authors.initials: P
authors.lastname: Manser
authors.forename: Philipp
authors.initials: P
authors.lastname: Spohn
authors.forename: Arie
authors.initials: A
authors.lastname: Bruinink
mesh_terms: D017209:Apoptosis; D002244:Carbon / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects*; D045744:Cell Line, Tumor; D002468:Cell Physiological Phenomena; D049109:Cell Proliferation / Q000187:drug effects*; D022082:Cellular Structures / Q000187:drug effects*; D003584:Cytological Techniques; D003599:Cytoskeleton / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D002244:Carbon