title: [Effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root on proinflammatory cytokine expression and regulation].
abstract: OBJECTIVE
  To study the effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root (OSS) on proinflammatory cytokine expression and regulation in rats.
  
  
  METHODS
  OA and LPS were injected intravenously to rats to develop acute lung injury (ALI). The rats were treated with OSS (45.19 microL kg(-1)). The pathological sections of lung tissue were prepared and observed in acute lung injury rats. The expression of nuclear factor-kappa B p65 (NF-kappaB p65), intercellar adhesion molecule CD54, and NF-kappaB p65 mRNA were determined in lung cells.
  
  
  RESULTS
  volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root significantly inhibited the expression of CD54, the activation of NF-kappaB p65, and the transcription of NF-kappaB p65 mRNA.
  
  
  CONCLUSIONS
  OSS can reduce the expression of CD54 and NF-kappaB p65 protein synthesis, which may be its anti-inflammatory molecular mechanisms.
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou 310053, China. geweihong@sina.com
authors.forename: Wei-hong
authors.initials: WH
authors.lastname: Ge
authors.forename: Jian-you
authors.initials: JY
authors.lastname: Guo
authors.forename: Ying-jun
authors.initials: YJ
authors.lastname: Shen
authors.forename: Min-li
authors.initials: ML
authors.lastname: Chen
authors.forename: Sen-lin
authors.initials: SL
authors.lastname: Shi
authors.forename: Yu-huan
authors.initials: YH
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry; D004338:Drug Combinations; D005786:Gene Expression Regulation / Q000187:drug effects; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D019686:Lamiaceae / Q000737:chemistry; D008070:Lipopolysaccharides; D008297:Male; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D019301:Oleic Acid; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D051996:Transcription Factor RelA / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D008070:Lipopolysaccharides; D009822:Oils, Volatile; D010938:Plant Oils; D012333:RNA, Messenger; D051996:Transcription Factor RelA; D018799:Intercellular Adhesion Molecule-1; D019301:Oleic Acid