title: Changes in regional cerebral blood flow demonstrated by 99mTc-HMPAO SPECT in euthymic bipolar patients.
abstract: Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to compare regional cerebral blood flow (rCBF) in patients with bipolar disorder and in healthy controls. The sample of this study consisted of 16 euthymic bipolar patients who met the DSM-IV criteria and 10 healthy control subjects. The mean regional cerebral blood flow values of the bipolar euthymic patients were significantly lower than those of the controls in the bilateral medial-basal temporal, occipital; medial frontal; parietal regions and in the cingulate gyrus; the hypoperfusion in the cingulate had the highest significant P value (.001, Bonferroni correction). No significant differences in rCBF emerged between right and left-brain regions. The most important findings of the current study are the presence of regional cerebral perfusion alterations, particularly in the cingulate gyrus in the euthymic bipolar patients. Our results imply that underlying brain dysfunction may be independent from manic or depressive episodes in bipolar disorder. Because of the small number of subjects, however, this finding should be viewed as preliminary.
authors.affiliation: Faculty of Medicine, Psychiatry Department, Pamukkale University, Denizli, Turkey. fatesci@yahoo.com
authors.forename: Atesci Figen
authors.initials: AF
authors.lastname: Culha
authors.forename: Ozdel
authors.initials: O
authors.lastname: Osman
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Dogangün
authors.forename: Karadag
authors.initials: K
authors.lastname: Filiz
authors.forename: Kirac
authors.initials: K
authors.lastname: Suna
authors.forename: Oguzhanoglu Nalan
authors.initials: ON
authors.lastname: Kalkan
authors.forename: Varma
authors.initials: V
authors.lastname: Gulfizar
authors.forename: Akdag
authors.initials: A
authors.lastname: Beyza
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D001714:Bipolar Disorder / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D019275:Radiopharmaceuticals / Q000378:metabolism; D012016:Reference Values; D019690:Technetium Tc 99m Exametazime / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime