title: Resident cardiac mast cells: are they the major culprit in the pathogenesis of cardiac hypertrophy?
abstract: Mast cells originate from pluripotent progenitor cells in bone marrow and are major players in the inflammation process. The involvements of mast cells in various cardiovascular complications such as arrhythmias, ischaemia reperfusion injury and graft rejection are well documented. Moreover, recent studies suggest the involvement of mast cells in cardiac hypertrophy and heart failure. The present review focuses on the role of mast cells in the development of cardiac hypertrophy and heart failure.
authors.affiliation: ISF Institute of Pharmaceutical Sciences and Drug Research, Moga, Punjab, India. pbala2002@rediffmail.com
authors.forename: Pitchai
authors.initials: P
authors.lastname: Balakumar
authors.forename: Amrit Pal
authors.initials: AP
authors.lastname: Singh
authors.forename: Subrahmanya S
authors.initials: SS
authors.lastname: Ganti
authors.forename: Pawan
authors.initials: P
authors.lastname: Krishan
authors.forename: Subbiah
authors.initials: S
authors.lastname: Ramasamy
authors.forename: Manjeet
authors.initials: M
authors.lastname: Singh
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000378:metabolism; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D015550:Cell Degranulation / Q000502:physiology; D018450:Disease Progression; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D001685:Biological Factors