An alkoxide-directed alkyne-allene cross-coupling for stereoselective synthesis of 1,4-dienes.
A titanium alkoxide-mediated convergent coupling between internal alkynes and allenes is described for the regio- and stereocontrolled synthesis of substituted acyclic 1,4-dienes.
Shimp
Heidi L
HL
Department of Chemistry, Yale University, New Haven, CT, USA.
Micalizio
Glenn C
GC
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D011090:Polyenes / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry
D000438:Alcohols; D000466:Alkadienes; D000480:Alkynes; D011090:Polyenes; C025947:propadiene; D014025:Titanium