Synovial sarcoma of the extremities and trunk: a long-lasting disease.
Synovial sarcoma (SS) of an extremity or trunk is relatively rare and is approached by limb sparing surgery (LSS), radiation therapy (RT) and chemotherapy. We conducted a retrospective analysis of the clinical and histopathological data of 73 patients with proven SS. At a median follow-up time of 6 years, local recurrence was seen in 17.8 and systemic recurrence 35.6% of patients (local-only, 6.8; systemic-only, 24.6; combined, 11%). The 10-year local recurrence-free survival (LRFS), systemic recurrence-free survival (SRFS) and overall survival (OS) rates were 78, 68 and 61%, respectively. LRFS was significantly better in patients treated with isolated limb perfusion (ILP); SRFS was influenced by the delay until diagnosis. The practical aspects of our observations are the need for long-term follow-up in order to diagnose recurrences, the fact that not all local or distant recurrences are necessarily associated with a shortening of OS time and the important role of induction ILP with TNF in cases of extremity SS.
Gofman
A
A
National Unit of Orthopedic Oncology, Tel-Aviv Sourasky Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
Issakov
J
J
Kollender
Y
Y
Soyfer
V
V
Dadia
S
S
Jiveliouk
I
I
Flusser
G
G
Bickels
J
J
Meller
I
I
Merimsky
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001132:Arm; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology*; D016019:Survival Analysis; D013997:Time Factors