Novel insight into the pathobiology of abdominal aortic aneurysm and potential future treatment concepts.
The patient with abdominal aortic aneurysm (AAA) commonly is a nondiabetic, white man with a history of smoking. Moreover, AAA represents a leading cause of death in elderly men in Western countries. The purpose of this manuscript is to review current evidence as to the pathobiology of AAA as well as potential future drug targets to prevent progression of AAA.
Diehm
Nicolas
N
Division of Clinical and Interventional Angiology, Swiss Cardiovascular Center, University Hospital and University of Bern, Bern, Switzerland.
Dick
Florian
F
Schaffner
Thomas
T
Schmidli
Juerg
J
Kalka
Christoph
C
Di Santo
Stefano
S
Voelzmann
Jan
J
Baumgartner
Iris
I
D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D050197:Atherosclerosis / Q000150:complications / Q000473:pathology; D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications / Q000473:pathology; D048670:MAP Kinase Kinase 4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D014815:Vitamins / Q000627:therapeutic use
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D002317:Cardiovascular Agents; D016326:Extracellular Matrix Proteins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011480:Protease Inhibitors; D014815:Vitamins; D048670:MAP Kinase Kinase 4; D010447:Peptide Hydrolases