title: Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats.
abstract: Stress is one of the basic factors in the etiology of number of diseases. Cold-stress occurs when the surrounding temperature drops below 18 degrees C, the body may not be able to warm itself, and hence serious cold-related illnesses, permanent tissue damage and death may results. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) against the cold stress-induced alterations in the behavioral and biochemical abnormalities in four different groups (saline control, Triphala, cold-stress and Triphala with cold-stress) of Wistar strain albino rats. In this study cold-stress (8 degrees C for 16 h/d/15 days) was applied and the oxidative stress was assessed by measuring the extent of lipid peroxidation (LPO) and the changes in corticosterone levels. Upon exposure to the cold-stress, a significant (P<0.05) increase in immobilization with decrease in rearing, grooming, and ambulation behavior was seen in open field. Following cold-exposure, significant increase in the LPO and corticosterone levels was observed. Oral administration of Triphala (1 g/kg/animal body weight) for 48 days significantly prevented these cold stress-induced behavioral and biochemical abnormalities in albino rats. The results of this study suggest that Triphala supplementation can be regarded as a protective drug against stress.
authors.affiliation: Department of Physiology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, India.
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Dhanalakshmi
authors.forename: Rathinasamy Sheela
authors.initials: RS
authors.lastname: Devi
authors.forename: Ramasundaram
authors.initials: R
authors.lastname: Srikumar
authors.forename: Sundaramahalingam
authors.initials: S
authors.lastname: Manikandan
authors.forename: Ramasundaram
authors.initials: R
authors.lastname: Thangaraj
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003080:Cold Temperature / Q000009:adverse effects*; D003345:Corticosterone / Q000378:metabolism*; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D001523:Mental Disorders / Q000209:etiology* / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; C520904:triphala; D003345:Corticosterone