[Study on adscription of plasma effective constituents of rat after administrated with Paeonia lacliflora and Glycyrrhiza uralensis compound].
OBJECTIVE
To study the adscription of plasma effective constituents of rat after oral administration of Paeonia lacliflora and Glycyrrhiza uralensis compound.


METHODS
Based on the established HPLC analytical method of plasma effective constituents, analysis and comparison were carried out among HPLC profiles of plasma samples obtained after oral administration of different ingredient preparations such as P. lacliflora and G. uralensis compound, single ingredient and all the preparations. The adscription of plasma effective compounds were identified.


RESULTS
Eighteen compounds were detected under this method, three of which are metabolites and thirteen are original forum of compounds contained in P. laclflora and G. uralensis compound.


CONCLUSIONS
This method is simple, accurate and stable, it could be used to analyze plasma effective constituents of P. lacliflora and G. uralensis compound. Affirmation of plasma effective compounds is the basis of to explore active compounds of P. lacliflora and G. uralensis compound.
Zhang
Liang
L
Technology Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xu
De-sheng
DS
Feng
Yi
Y
D000284:Administration, Oral; D000818:Animals; D001565:Benzoates / Q000097:blood*; D001952:Bridged-Ring Compounds / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005960:Glucosides / Q000097:blood*; D006034:Glycyrrhetinic Acid / Q000097:blood; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000097:blood*; D008297:Male; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006034:Glycyrrhetinic Acid; D019695:Glycyrrhizic Acid; D039821:Monoterpenes; C015423:peoniflorin; D006027:Glycosides