title: Absence of paternal accessory sex glands dysregulates preimplantation embryo cell cycle and causes early oviductal-uterine transit in the golden hamster in vivo.
abstract: We hypothesize that deletion of paternal accessory sex glands compromised developmental potential of preimplantation embryos because of dysregulation of blastomeric cell cycle regulators. Quantification by immunocytochemistry showed disrupted cyclicity of proliferating cell nuclear antigen, augmented p53 and p21 expression, and premature transit from oviduct to uterus.
authors.affiliation: Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
authors.forename: Chun Lung
authors.initials: CL
authors.lastname: Wong
authors.forename: Oi Chi
authors.initials: OC
authors.lastname: Chan
authors.forename: Ka Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Wai Sum
authors.initials: WS
authors.lastname: O
authors.forename: Pak Ham
authors.initials: PH
authors.lastname: Chow
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D002453:Cell Cycle; D006224:Cricetinae; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000032:analysis; D010064:Embryo Implantation; D047108:Embryonic Development; D005260:Female; D005837:Genitalia, Male / Q000601:surgery*; D007150:Immunohistochemistry; D008297:Male; D008647:Mesocricetus; D010066:Ovum Transport; D011247:Pregnancy; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051135:Rad51 Recombinase / Q000032:analysis; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; D051135:Rad51 Recombinase