title: Green pit viper (Trimeresurus albolabris and T. macrops) venom antigenaemia and kinetics in humans.
abstract: Green pit viper bite is a common public health problem in Southeast Asia. Although most patients experience only local swelling, some may suffer from severe systemic bleeding that can be delayed. Venom antigenaemia was measured by enzyme-linked immunosorbent assay and correlated with clinical findings in 42 patients. Initial venom antigenaemia was not predictive enough for clinical uses. A kinetic study (n = 27) showed highest levels at presentation and, then, progressive decline. The average half-life was 27.5 h during the first three days and over 50 h on days 5-7 after bite. Two small subsets (7.4% each) showed persistently detectable venom on day 14 and a subsequent rise in venom antigenaemia. They were associated with prolonged thrombocytopaenia and coagulopathy, respectively. These data demonstrated the long half-life of the venom, suggesting that waiting for spontaneous resolution of coagulopathy is not preferable. In addition, the delayed venom disappearance, not the initial values, was correlated with haemostatic disorders.
authors.affiliation: Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. porpiasod@hotmail.com
authors.forename: Ponlapat
authors.initials: P
authors.lastname: Rojnuckarin
authors.forename: Sukit
authors.initials: S
authors.lastname: Banjongkit
authors.forename: Walee
authors.initials: W
authors.lastname: Chantawibun
authors.forename: Benjaporn
authors.initials: B
authors.lastname: Akkawat
authors.forename: Jumlong
authors.initials: J
authors.lastname: Juntiang
authors.forename: Jureeporn
authors.initials: J
authors.lastname: Noiphrom
authors.forename: Narumol
authors.initials: N
authors.lastname: Pakmanee
authors.forename: Tanin
authors.initials: T
authors.lastname: Intragumtornchai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000941:Antigens / Q000097:blood*; D000997:Antivenins / Q000627:therapeutic use; D003435:Crotalid Venoms / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005121:Extremities / Q000293:injuries; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012720:Severity of Illness Index; D012909:Snake Bites / Q000188:drug therapy / Q000503:physiopathology; D013921:Thrombocytopenia; D013997:Time Factors; D000979:alpha-2-Antiplasmin / Q000032:analysis
chemical_list: D000941:Antigens; D000997:Antivenins; D003435:Crotalid Venoms; C029748:Trimeresurus venoms; D000979:alpha-2-Antiplasmin; D005340:Fibrinogen