title: Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample.
abstract: This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.
authors.affiliation: Centre de Recerca en Enginyeria Biomedica, Dept. d'Eng. Sistemes i Automatica Industrial, Universitat Politecnica de Catalunya, Pau Gargallo, 5, 08028 Barcelona, Spain. alexandre.perera@upc.edu
authors.forename: Alexandre
authors.initials: A
authors.lastname: Perera
authors.forename: Alfonso
authors.initials: A
authors.lastname: Buil
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Di Bernardo
authors.forename: Maria
authors.initials: M
authors.lastname: Sabater-Lleal
authors.forename: Linda
authors.initials: L
authors.lastname: Pattini
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Souto
authors.forename: Jordi
authors.initials: J
authors.lastname: Fontcuberta
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vallverdu
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Soria
authors.forename: Pere
authors.initials: P
authors.lastname: Caminal
mesh_terms: D000704:Analysis of Variance; D016000:Cluster Analysis; D005167:Factor VII / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D019851:Thrombophilia / Q000235:genetics*
chemical_list: D005167:Factor VII