title: Zymogen activation, inhibition, and ectodomain shedding of matriptase.
abstract: Matriptase is a member of an expanding group of type II transmembrane serine proteases. Recently, much has been learned about the biochemistry, cellular biology, normal tissue physiology, and human pathology of this protease, and of its inhibitor, termed the hepatocyte growth factor inhibitor-1 (HAI-1). This review examines the recent literature that has characterized the regulation of matriptase and HAI-1 with an emphasis on the molecular mechanisms governing its zymogen activation, inhibition by HAI-1, and ectodomain shedding.
authors.affiliation: Department of Biochemistry and Molecular Biology, Greenborne Cancer Center, University of Maryland, School of Medicine, Baltimore, MD 21201, USA. cylin@som.umaryland
authors.forename: Chen-Yong
authors.initials: CY
authors.lastname: Lin
authors.forename: I-Chu
authors.initials: IC
authors.lastname: Tseng
authors.forename: Feng-Pai
authors.initials: FP
authors.lastname: Chou
authors.forename: Sheng-Fang
authors.initials: SF
authors.lastname: Su
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Chen
authors.forename: Michael D
authors.initials: MD
authors.lastname: Johnson
authors.forename: Robert B
authors.initials: RB
authors.lastname: Dickson
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D003600:Cytosol / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D011487:Protein Conformation; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry* / Q000378:metabolism; D012697:Serine Endopeptidases / Q000737:chemistry*; D013498:Suramin / Q000737:chemistry
chemical_list: D000911:Antibodies, Monoclonal; D008246:Lysophospholipids; D008562:Membrane Glycoproteins; D053491:Proteinase Inhibitory Proteins, Secretory; C109149:SPINT1 protein, human; D013498:Suramin; D012697:Serine Endopeptidases; C485595:matriptase