title: Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children.
abstract: Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is an adhesive phenotype commonly found in field isolates that has previously been associated with severe malaria. Here, clumping was assessed in 131 isolates from Malian children. The clumping phenotype was seen in 6% (N = 51) of uncomplicated malaria, 24% (N = 51) of severe malaria, and 45% (N = 29) of high parasitemia non-severe malaria isolates. Multivariate analysis indicated that clumping was strongly positively associated with parasitemia (F(1,122) = 24.1, P < 0.001) but not with disease category (F(2,122) = 1.8, P = 0.17). Therefore platelet-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria.
authors.affiliation: Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Mònica
authors.initials: M
authors.lastname: Arman
authors.forename: Ahmed
authors.initials: A
authors.lastname: Raza
authors.forename: Louisa J
authors.initials: LJ
authors.lastname: Tempest
authors.forename: Kirsten E
authors.initials: KE
authors.lastname: Lyke
authors.forename: Mahamadou A
authors.initials: MA
authors.lastname: Thera
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Koné
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Plowe
authors.forename: Ogobara K
authors.initials: OK
authors.lastname: Doumbo
authors.forename: J Alexandra
authors.initials: JA
authors.lastname: Rowe
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D002648:Child; D004912:Erythrocytes / Q000469:parasitology*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood*; D008297:Male; D008302:Mali / Q000453:epidemiology; D018512:Parasitemia; D010963:Plasmodium falciparum