title: [Case of minocycline-induced pneumonitis with bilateral pleural effusion].
abstract: A 51-year-old man was admitted to our hospital with fever, dry cough and dyspnea. He had taken minocycline for 11 days because of urinary tract infection. Chest X-ray on admission showed diffuse reticular shadows in bilateral lung fields with bilateral pleural effusion. Cessation of minocycline led to spontaneous improvement of symptoms and radiographic findings. The lymphocyte stimulation test for minocycline with peripheral blood and pleural effusion were negative. After provocation test with minocycline, he developed fever and dry cough and bilateral ground glass opacity appeared on his chest X-ray. He was diagnosed as minocycline-induced pneumonitis and recovered rapidly following corticosteroid therapy.
authors.affiliation: Department of Respiratory Medicine, International Medical Center of Japan, Japan. a-satoko@dokkyomed.ac.jp
authors.forename: Satoko
authors.initials: S
authors.lastname: Arai
authors.forename: Yuka
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
authors.forename: Atsuto
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hojyo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Haruhito
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010996:Pleural Effusion / Q000209:etiology*; D011014:Pneumonia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D013902:Radiography, Thoracic; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline; D008775:Methylprednisolone