Serum interleukin-18 levels are raised in diabetic ketoacidosis in Chinese children with type 1 diabetes mellitus.
OBJECTIVE
To investigate the role of serum interleukin (IL-18) in children with type 1 diabetes mellitus (T1DM) and diabetic ketoacidosis (DKA).


METHODS
Case-control study.


METHODS
Sixty-one children with T1DM including 28 with DKA and 33 without DKA and 30 age - and sex-matched healthy controls were recruited.


METHODS
Serum IL-18, IL-12, and IFN-gamma levels were measured in all subjects by enzyme linked immunosorbent assay.


RESULTS
Serum IL-18 levels were significantly higher in patients with DKA than those in patients without DKA (759.2 +/- 353.8 pg/mL vs. 634.9 +/- 399.7 pg/mL, P = 0.001) and healthy controls (310.0 +/- 265.3 pg/mL). The serum IL-12 and IFN-gamma levels were not different between patients and controls (277.5 +/- 207 pg/mL vs. 351.4 +/- 223.4 pg/mL, P = 0.45 and 7.02 +/- 7.53 pg/mL vs. 5.59 +/- 5.34 pg/mL, P = 0.21, respectively).


CONCLUSIONS
Serum IL-18 levels are increased in children with type 1 diabetes mellitus and could be a predictor of diabetic ketoacidosis.
Dong
Guanping
G
Department of Endocrinology, The Children's Hospital of Zhejiang University, School of Medicine, 57 Zhugan Xiang, Hangzhou, China. dongguanp@yahoo.com.cn
Liang
Li
L
Fu
Junfen
J
Zou
Chaochun
C
D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000208:ethnology*; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000208:ethnology* / Q000209:etiology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male
D020382:Interleukin-18