title: Binding of nanoparticle receptors to peptide alpha-helices using amino acid-functionalized nanoparticles.
abstract: Nanoparticles provide large surface areas and controlled surface functionality and structure, making them excellent scaffolds for peptide recognition. A family of nanoparticles has been fabricated by amino acid functionalization to afford tailored surfaces. These particles are complementary to a tetraaspartate peptide (TAP) featuring cofacial anionic functionality when in the alpha-helical conformation. The functional groups present on these nanoparticle surfaces provide a tool to investigate the contribution of various noncovalent interactions at the nanoparticle-peptide interface. The ability of these particles to enforce the folding of the peptide into an alpha-helix was explored, demonstrating high helicity induction with particles featuring dicationic amino acids such as lysine or histidine, and little or no helix stabilization with hydrophobic amino acid termini.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Partha S
authors.initials: PS
authors.lastname: Ghosh
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Belma
authors.initials: B
authors.lastname: Erdogan
authors.forename: Olga
authors.initials: O
authors.lastname: Rosado
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D002942:Circular Dichroism; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D018000:Receptors, Peptide / Q000737:chemistry* / Q000648:ultrastructure; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000596:Amino Acids; D008024:Ligands; D010455:Peptides; D018000:Receptors, Peptide; D013438:Sulfhydryl Compounds