title: Increased frequency of thyroid nodules and breast fibroadenomas in women with uterine fibroids.
abstract: Fibroids or leiomyomas or myomas of the uterus are the most common benign gynecologic disease, while fibroadenomas of the breast are most frequently seen in young women, usually within 20 years after puberty. Multiple tumors in one or both breasts are found in 10-15% of patients. Single thyroid nodules are much more common in women than in men, and their prevalence increases with age. The aim of the present study was to determine cross-sectionally the incidence of solitary thyroid nodules and fibroadenomas of the breast in women with uterine fibroids. In women with uterine adenomas, the frequency of fibroadenomas of the breast was 65% and of thyroid nodules was 38.7%, while in women with a normal uterus, the frequency was 35% and 20%, respectively. Therefore, women with uterine fibroids have an increased incidence of thyroid nodules (t = 4.68, p = 0.030) and of fibroadenomas of the breast (t = 11.74, p = 0.001).
authors.affiliation: Department of Obstetrics and Gynecology, University of Patras Medical School, Rio, Patras, Greece.
authors.forename: Nikitas
authors.initials: N
authors.lastname: Spinos
authors.forename: George
authors.initials: G
authors.lastname: Terzis
authors.forename: Athina
authors.initials: A
authors.lastname: Crysanthopoulou
authors.forename: George
authors.initials: G
authors.lastname: Adonakis
authors.forename: Kostas B
authors.initials: KB
authors.lastname: Markou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Vervita
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Koukouras
authors.forename: Vasilios
authors.initials: V
authors.lastname: Tsapanos
authors.forename: George
authors.initials: G
authors.lastname: Decavalas
authors.forename: George
authors.initials: G
authors.lastname: Kourounis
authors.forename: Neoklis A
authors.initials: NA
authors.lastname: Georgopoulos
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D018226:Fibroadenoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D015994:Incidence; D007889:Leiomyoma / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D012307:Risk Factors; D016606:Thyroid Nodule / Q000150:complications* / Q000175:diagnosis