Association of adipose most abundant transcript 1 gene (apM1) with type 2 diabetes mellitus in a Chinese population: a meta-analysis of case-control studies.
BACKGROUND
Polymorphisms of the adipose most abundant transcript 1 gene (apM1) may be closely associated with type 2 diabetes mellitus (T2DM) as described in several recent publications. In the present study, a meta-analysis was performed to quantitatively analyse the association of apM1 polymorphisms with T2DM using previous case-control studies in Chinese populations.


METHODS
Several electronic databases were searched for relevant articles up to January 2007. After data collection and gene loci selection, a meta-analysis was performed to assess heterogeneity, combine results and evaluate variations. Publication bias was examined by the Egger's linear regression test and fail-safe number for P = 0.05 (Nfs(0.05)). Hardy-Weinberg equilibrium (HWE) test and different effect models were employed for the sensitivity analysis.


RESULTS
The meta-analysis for this study included 2379 subjects from nine studies. The distribution of SNP45TG + GG and SNP276GG polymorphisms of the apM1 was analysed. Results of these experiments revealed a significant association between the SNP45TG + GG and SNP276GG polymorphisms of apM1 with T2DM in Chinese populations (P < or = 0.05). There was some heterogeneity in the SNP45TG + GG apM1 among these studies. The odds ratio (OR) of apM1 genotype SNP45TG + GG in T2DM was 1.59 when compared with controls (95% CI, 1.00-2.53, P = 0.05), and the OR for the wild-apM1 genotype SNP276GG in T2DM was 1.26 (95% CI, 1.00-1.59, P = 0.05). The publication bias diagnostics and sensitivity analysis confirmed the reliability and stability of this meta-analysis.


CONCLUSIONS
This apM1 polymorphism was found to be strongly associated with T2DM, and the SNP45TG + GG and SNP276GG forms of the apM1 increased risk for T2DM in Chinese populations.
Li
Shengbing
S
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Li
Ling
L
Li
Ke
K
Qi
Xiaoya
X
Hoekema
Dale
D
Liu
Hua
H
Yang
Gangyi
G
D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D012680:Sensitivity and Specificity
C499918:ADIPOQ protein, human; D052242:Adiponectin