Risk of sudden death and acute life-threatening events in patients with glutaric acidemia type II.
Glutaric acidemia type II (GAII) is an inborn error of metabolism caused by defects in electron transport flavoprotein (ETF) or ETF-ubiquinone oxidoreductase (ETF-QO) and typically presents with hypo- or nonketotic hypoglycemia and metabolic acidosis. The most severe forms present in early infancy and are associated with a high mortality rate. The disorder can now be detected by expanded newborn screening using tandem mass spectrometry (MS/MS), providing the opportunity for diagnosis and treatment in asymptomatic infants. We report here three infants who, despite diagnosis and treatment in the neonatal period, experienced either unexpected sudden death or an acute life-threatening event (ALTE) during the first year of life. The possible etiologies of these events and the potential impact of expanded newborn screening on the long-term outcome of GAII are discussed.
Angle
Brad
B
Division of Birth Defects and Metabolism, Department of Pediatrics, Children's Memorial Hospital, Northwestern University, Feinberg School of Medicine, 2300 Children's Plaza, Chicago, IL 60614, USA. bangle@childrensmemorial.org
Burton
Barbara K
BK
D000208:Acute Disease; D003645:Death, Sudden / Q000209:etiology*; D044927:Electron-Transferring Flavoproteins / Q000235:genetics; D017809:Fatal Outcome; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007506:Iron-Sulfur Proteins / Q000235:genetics; D054069:Multiple Acyl Coenzyme A Dehydrogenase Deficiency / Q000150:complications* / Q000235:genetics; D015997:Neonatal Screening; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D012307:Risk Factors
D044927:Electron-Transferring Flavoproteins; D007506:Iron-Sulfur Proteins; D000587:Oxidoreductases Acting on CH-NH Group Donors; C023120:electron-transferring-flavoprotein dehydrogenase