title: Pentaketides relating to aspinonene and dihydroaspyrone from a marine-derived fungus, Aspergillus ostianus.
abstract: Three new pentaketides, aspinotriols A ( 1) and B ( 3) and aspinonediol ( 5), were isolated together with two known compounds, aspinonene ( 7) and dihydroaspyrone ( 9), from the marine fungus Aspergillus ostianus strain 01F313, which was collected in Pohnpei and cultured with bromine-modified artificial seawater. The structures of the new compounds were determined by spectroscopic analyses including 1D and 2D NMR. Although 1 and 3 are diastereomers, they show nearly superimposable (1)H and (13)C NMR spectra. The absolute configurations of compounds 1, 3, 5, and 9 were elucidated by the modified Mosher's method.
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.
authors.forename: Keijiro
authors.initials: K
authors.lastname: Kito
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Ookura
authors.forename: Sanae
authors.initials: S
authors.lastname: Yoshida
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ooi
authors.forename: Takenori
authors.initials: T
authors.lastname: Kusumi
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D011090:Polyenes; D011753:Pyrones; C097479:aspyrone