title: Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents.
abstract: Tetrapyrrole ethanolamide derivatives, 1 and 2, were prepared from hematoporphyrin IX (HPIX, 3) and methyl pheophorbide a (mPheo, 6). These were evaluated for their dual action as chemotherapeutics and photosensitizers in treatment of cancer. The novel compounds showed significant in vitro anticancer activity as measured in different cell lines using the MTT assay and photodynamic activity measured by erythrocytes' photohemolysis.
authors.affiliation: Département de Chimie-Biologie, Université du Québec à Trois-Rivières, Trois-Rivières, Que., Canada G9A 5H7.
authors.forename: Denis
authors.initials: D
authors.lastname: Girard
authors.forename: Glenn
authors.initials: G
authors.lastname: Weagle
authors.forename: Atul
authors.initials: A
authors.lastname: Gupta
authors.forename: Gervais
authors.initials: G
authors.lastname: Bérubé
authors.forename: Camille
authors.initials: C
authors.lastname: Chapados
mesh_terms: D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D000431:Ethanol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006415:Hematoporphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045725:Tetrapyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D045725:Tetrapyrroles; C093722:hematoporphyrin IX di-N-propyletherdiethanolamide; C553809:pheophorbide a ethanolamide; D002734:Chlorophyll; D000431:Ethanol