Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles.
The parent pyrrolidino[2',3':3,4]pyrrolidino[1,2-a]benzimidazole heterocycle as well as a series of novel analogues have been synthesized utilizing a microwave-assisted intramolecular cycloaddition of azomethine ylides as the key transformation. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
Meng
Liping
L
Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
Fettinger
James C
JC
Kurth
Mark J
MJ
D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
D001391:Azo Compounds; D001562:Benzimidazoles; D013882:Thiosemicarbazones; C512188:azomethine