Parental transmission of HLA-DRB1*15 in multiple sclerosis.
Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.
Ramagopalan
Sreeram V
SV
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Herrera
Blanca M
BM
Bell
Jordana T
JT
Dyment
David A
DA
Deluca
Gabriele C
GC
Lincoln
Matthew R
MR
Orton
Sarah M
SM
Chao
Michael J
MJ
Sadovnick
A Dessa
AD
Ebers
George C
GC
D002648:Child; D015331:Cohort Studies; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010290:Parents
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C507799:HLA-DRB1*15 antigen