[Effect of Liriope platyphylla total saponin on learning, memory and metabolites in aging mice induced by D-galactose].
OBJECTIVE
To investigate the effects of Liriope platyphylla total saponin (LPTS) on learning, memory, neuromediators and metabolites in aging mice induced by D-galactose.


METHODS
Ninety Kunming mice were randomly divided into nine groups: normal saline (NS)-treated group, untreated group, high- (100 mg/kg), medium- (50 mg/kg) and low-dose (10 mg/kg) LPTS-treated groups, Shuxuening-treated group, jiaogulanosidi-treated group, flunarizine-treated group and vitamin E-treated group. The Kunming mice in the NS-treated group were administered with NS by intraperitoneal injection, while the aging mice in the other eight groups were administered with D-galactose by intraperitoneal injection. At the same time, the aging mice in different groups were fed with corresponding drugs for 42 days, and the aging items of the mice in different groups were measured, respectively.


RESULTS
LPTS could improve the memory of aging mice induced by D-galactose, promote its body weight, and increase the thymus and spleen indexes of the aging mice. LPTS could decrease the levels of MDA and lipofuscin, inhibit MAO activity and increase SOD activity and GSH-Px level.


CONCLUSIONS
LPTS may improve the ability of learning and memory and delay aging.
Jiang
Tao
T
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Huang
Bao-kang
BK
Zhang
Qiao-yan
QY
Han
Ting
T
Zheng
Han-chen
HC
Qin
Lu-ping
LP
D000375:Aging / Q000187:drug effects*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005690:Galactose; D007858:Learning / Q000187:drug effects; D031424:Liriope Plant / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D008517:Phytotherapy; D011897:Random Allocation; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D012503:Saponins; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D005690:Galactose