title: LOCATE: a mammalian protein subcellular localization database.
abstract: LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins. Over the past 2 years, the data in LOCATE have grown substantially. The database now contains high-quality localization data for 20% of the mouse proteome and general localization annotation for nearly 36% of the mouse proteome. The proteome annotated in LOCATE is from the RIKEN FANTOM Consortium Isoform Protein Sequence sets which contains 58 128 mouse and 64 637 human protein isoforms. Other additions include computational subcellular localization predictions, automated computational classification of experimental localization image data, prediction of protein sorting signals and third party submission of literature data. Collectively, this database provides localization proteome for individual subcellular compartments that will underpin future systematic investigations of these regions. It is available at http://locate.imb.uq.edu.au/
authors.affiliation: ARC Centre of Excellence in Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
authors.forename: Josefine
authors.initials: J
authors.lastname: Sprenger
authors.forename: J
authors.initials: J
authors.lastname: Lynn Fink
authors.forename: Seetha
authors.initials: S
authors.lastname: Karunaratne
authors.forename: Kelly
authors.initials: K
authors.lastname: Hanson
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Hamilton
authors.forename: Rohan D
authors.initials: RD
authors.lastname: Teasdale
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D002451:Cell Compartmentation; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry*; D051379:Mice; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000032:analysis*; D040901:Proteomics
chemical_list: D008565:Membrane Proteins; D011506:Proteins