Absence of paternal accessory sex glands dysregulates preimplantation embryo cell cycle and causes early oviductal-uterine transit in the golden hamster in vivo.
We hypothesize that deletion of paternal accessory sex glands compromised developmental potential of preimplantation embryos because of dysregulation of blastomeric cell cycle regulators. Quantification by immunocytochemistry showed disrupted cyclicity of proliferating cell nuclear antigen, augmented p53 and p21 expression, and premature transit from oviduct to uterus.
Wong
Chun Lung
CL
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Chan
Oi Chi
OC
Lee
Ka Ho
KH
O
Wai Sum
WS
Chow
Pak Ham
PH
D000818:Animals; D001755:Blastocyst / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D002453:Cell Cycle; D006224:Cricetinae; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000032:analysis; D010064:Embryo Implantation; D047108:Embryonic Development; D005260:Female; D005837:Genitalia, Male / Q000601:surgery*; D007150:Immunohistochemistry; D008297:Male; D008647:Mesocricetus; D010066:Ovum Transport; D011247:Pregnancy; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051135:Rad51 Recombinase / Q000032:analysis; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D050759:Cyclin-Dependent Kinase Inhibitor p21; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; D051135:Rad51 Recombinase