title: Poecillastrin D: a new cytotoxin of the chondropsin class from marine sponge Jaspis serpentina.
abstract: Poecillastrin D (2) was isolated together with poecillastrin C (1) from the deep sea sponge, Japsis serpentina. Its structure was elucidated to be that of a macrolide lactam by spectroscopic methods. These compounds showed potent cytotoxicity against various tumor cell lines.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, USA.
authors.forename: Daisaku
authors.initials: D
authors.lastname: Takemoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takekawa
authors.forename: Rob W M van
authors.initials: RW
authors.lastname: Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D007769:Lactams; D018942:Macrolides; C519147:poecillastrin C; C526217:poecillastrin D