[Study on skin toxicology and penetration enhancement of skin absorption of volatile oil extracted from tender branchers of Camellia oleifera].
OBJECTIVE
To study the toxicity on skin and penetration effect of volatile oil from tender branchers of Camellia oleifera on nitrendipine, baicalin, nimesulide for percutaneous obsorption.


METHODS
Acute skin toxicity, irritation and allergy on rats were tested, and mouse skin in vitro was applied for studying the effects of different concentrations of volatile oil in nitrendipine, baicalin, nimesulide on drug permeation.


RESULTS
Different dosage volatile oil had no acute toxicity, irritation or hypersensitive effects. Compared to azone, more powerful enhancement effects of volatile oil at different concentration on nitrendipine, baicalin, nimesulide were very obvious.


CONCLUSIONS
This paper firstly reported the results of experiment about the toxicity to skin and penetr-ation effect of volatile oil from tender branches of C. oleifera.
Long
Zheng-hai
ZH
Zhejiang Pharmaceutical College, Ningbo 315100, China. longzh@mail.zjpc.net.cn
Yang
Zai-chang
ZC
Yang
Xiong-zhi
XZ
D000279:Administration, Cutaneous; D000818:Animals; D028244:Camellia / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009568:Nitrendipine / Q000008:administration & dosage / Q000493:pharmacokinetics; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010539:Permeability / Q000187:drug effects; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D013449:Sulfonamides / Q000008:administration & dosage / Q000493:pharmacokinetics
D005419:Flavonoids; D009822:Oils, Volatile; D010938:Plant Oils; D013449:Sulfonamides; C038044:baicalin; D009568:Nitrendipine; C012655:nimesulide