[Analytical application of phosphotungstic acid complexes. Synthesis and characterisation].
Phosphotungstic acid forms salt type ionic association complexes with a large number of medicinal drugs that contain cation forming proton acceptor moieties.


METHODS
Ranitidine, nizatidine and famotidine complexes with phosphotungstic acid were synthesized and subsequently characterized by their melting point, water solubility, specific absorbance, UV spectra and IR spectra.


RESULTS
These sparingly soluble complexes were applied for the fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.


CONCLUSIONS
There have been synthesized phosphotungstic acid complexes with uses in fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.
Apostu
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Facultatea de Farmacie, Disciplina de Chimie Analitică, Universitatea de Medicină si Farmacie "Gr.T. Pop" Iaşi.
Dorneanu
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V
Bibire
Nela
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D000897:Anti-Ulcer Agents / Q000737:chemistry; D015738:Famotidine / Q000737:chemistry; D006801:Humans; D016567:Nizatidine / Q000737:chemistry; D010772:Phosphotungstic Acid / Q000737:chemistry* / Q000494:pharmacology; D011899:Ranitidine / Q000737:chemistry
D000897:Anti-Ulcer Agents; D010772:Phosphotungstic Acid; D015738:Famotidine; D011899:Ranitidine; D016567:Nizatidine