title: Serum levels of ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol in prepubertal children with iron deficiency.
abstract: The aim of the present study is to investigate possible alterations in ghrelin and other hormone levels related to appetite and somatic growth in children with iron deficiency anemia. Twenty-five patients and 25 healthy controls that were prepubertal and within normal limits regarding height and BMI standard deviation scores were recruited. Ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol levels were studied. Ghrelin, insulin and IGF-I levels were significantly low in the study group (ghrelin 13.58 +/- 16.32 vs. 35.39 +/- 23.69 ng/ml, p<.001; insulin 3.41 +/- 2.42 vs. 5.67 +/- 1.09 mU/ml, p = .008 and IGF-I 126.94 +/- 92.82 vs. 203 +/- 105.1 ng/ml, p = .015). We concluded that low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.
authors.affiliation: Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Isguven
authors.forename: Ilknur
authors.initials: I
authors.lastname: Arslanoglu
authors.forename: Melih
authors.initials: M
authors.lastname: Erol
authors.forename: Metin
authors.initials: M
authors.lastname: Yildiz
authors.forename: Erdal
authors.initials: E
authors.lastname: Adal
authors.forename: Muferret
authors.initials: M
authors.lastname: Erguven
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood; D054439:Ghrelin / Q000097:blood*; D006400:Hematocrit; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007501:Iron / Q000097:blood; D008297:Male; D018709:Statistics, Nonparametric; D013963:Thyroid Hormones / Q000097:blood*; D014168:Transferrin / Q000378:metabolism
chemical_list: D054439:Ghrelin; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D013963:Thyroid Hormones; D014168:Transferrin; D007334:Insulin-Like Growth Factor I; D005293:Ferritins; D007501:Iron; D006854:Hydrocortisone