A simple synthesis of 2-thiohydantoins.
2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an alpha-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Wang
Zerong Daniel
ZD
Department of Chemistry, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, TX 77058, USA. wang@uhcl.edu
Sheikh
Samia O
SO
Zhang
Yulu
Y
D000596:Amino Acids / Q000737:chemistry; D013696:Temperature; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry; D013997:Time Factors
D000596:Amino Acids; D013867:Thiohydantoins; D013890:Thiourea