title: Fatal hypertensive crisis as presentation of mitochondrial complex I deficiency.
abstract: Complex I deficiency is a frequent defect of the mitochondrial electron transport chain. We report on a 3-year-old boy, who rapidly deteriorated after sudden flushing and collapse. This fatal and unusual case was characterized by widely uncontrollable arterial hypertension. It might indicate that hypertensive crisis could be a potential manifestation of mitochondrial disorders.
authors.affiliation: Department of General Pediatrics, Heinrich-Heine-Universität, Düsseldorf, Germany. lohmeier@uni-duesseldorf.de
authors.forename: K
authors.initials: K
authors.lastname: Lohmeier
authors.forename: F
authors.initials: F
authors.lastname: Distelmaier
authors.forename: L P
authors.initials: LP
authors.lastname: van den Heuvel
authors.forename: R J T
authors.initials: RJ
authors.lastname: Rodenburg
authors.forename: J
authors.initials: J
authors.lastname: Smeitink
authors.forename: E
authors.initials: E
authors.lastname: Mayatepek
authors.forename: T
authors.initials: T
authors.lastname: Hoehn
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D002540:Cerebral Cortex / Q000473:pathology*; D002675:Child, Preschool; D042967:Electron Transport Complex I / Q000172:deficiency*; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008297:Male; D028361:Mitochondrial Diseases / Q000150:complications* / Q000201:enzymology / Q000473:pathology
chemical_list: D000959:Antihypertensive Agents; D042967:Electron Transport Complex I