title: The first ten years: achievements and challenges of the Brazilian program of universal access to HIV/AIDS comprehensive management and care, 1996-2006.
abstract: A review was carried out of papers published between 1996 and 2006, documenting the introduction of highly active anti-retroviral therapy (HAART) in Brazil. Papers indexed in the MEDLINE and SciELO databases were retrieved using different combinations of keywords related to the management and care of AIDS in the post-HAART era: opportunistic diseases and co-infections, adherence to therapy, survival in the pre- and post-HAART eras, adverse events and side-effects, emergence and possible transmission of resistant viral strains, metabolic and cardiovascular disorders, and issues related to access to care and equity. The review documents the dramatic changes in HIV/AIDS disease progression in the post-HAART era, including an increase in survival and quality of life and a pronounced decrease in the episodes of opportunistic diseases. Notwithstanding such major achievements, new challenges have emerged, including slow evolving co-infections (such as hepatitis C, metabolic and cardiovascular disorders), the emergence of viral resistance, with consequences at the individual level (virological failure) and the community level (primary/secondary resistance at the population level), and impacts on the cost of new therapeutic regimens.
authors.affiliation: Instituto de Comunicação e Informação Científica e Tecnológica em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: Mariana A
authors.initials: MA
authors.lastname: Hacker
authors.forename: Angela
authors.initials: A
authors.lastname: Kaida
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hogg
authors.forename: Francisco I
authors.initials: FI
authors.lastname: Bastos
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001938:Brazil / Q000453:epidemiology; D003695:Delivery of Health Care; D024882:Drug Resistance, Viral; D016021:Epidemiologic Studies; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008659:Metabolic Diseases / Q000150:complications; D009313:National Health Programs; D010349:Patient Compliance; D011788:Quality of Life; D015996:Survival Rate