title: [Interferon-stimulating activity of muramoyl dipeptide glycosides].
abstract: The uninvestigated interferon (IFN)-inducing capacity of glycoside derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) has been studied. Most MDP glycosides tested in vitro were more active than the reference preparation MDP. Under the in vivo conditions three studied preparations: MDP, a-heptyl-MDP and beta-(2-methyl-3-phenylchromonyl-7)-MDP stimulated production of considerable amount of circulating IFN that evidences for the promising character of their further investigation as preparations immunostimulators.
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Spivak
authors.forename: A E
authors.initials: AE
authors.lastname: Zemliakov
authors.forename: V V
authors.initials: VV
authors.lastname: Tsikalov
authors.forename: T A
authors.initials: TA
authors.lastname: Chupakhina
authors.forename: V O
authors.initials: VO
authors.lastname: Kur'ianov
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Chirva
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000737:chemistry / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
chemical_list: D006027:Glycosides; D007369:Interferon Inducers; D010835:Phytohemagglutinins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007372:Interferons