title: Growth pattern and final height in 21-hydroxylase deficiency.
abstract: Growth pattern and final height were evaluated in 47 children with 21-hydroxylase deficiency to identify factors influencing growth. The subjects were followed-up from the age of 0.6 +/- 1.2 years for 8.8 +/- 3.9 years. Final height SDS was significantly below target height SDS (- 2.5 +/- 1.4 versus - 1.0 +/- 1.0, P < 0.001). Laboratory monitoring and type of disease (salt-wasting or simple virilizing) significantly influenced age-specific height SDS. Age at treatment, frequency of laboratory monitoring and dose of glucocorticoid during infancy influenced final height on univariate analysis; the effect was not sustained on multivariate analysis. Our study emphasizes the need for regular laboratory monitoring and lower glucocorticoid dose during infancy in 21-hydroxylase deficiency.
authors.affiliation: FRIGE House (Foundation for Research in Genetics and Endocrinology), Genetic Center, 15 Kapidwaj, Jodhpur Gam Road, Satellite, Ahmedabad, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Bajpai
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.forename: Madhulika
authors.initials: M
authors.lastname: Kabra
authors.forename: P S N
authors.initials: PS
authors.lastname: Menon
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000503:physiopathology*; D001827:Body Height; D002648:Child; D002657:Child Development / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies