title: Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.
abstract: To further clarify schizophrenia (SCZ), disrupted in schizophrenia 1 (DISC1) is a promising candidate gene expressed predominantly within the hippocampus. Several lines of evidence suggest that DISC1 may be involved in susceptibility to SCZ. In this study, we investigated whether genetic polymorphisms in the coding region of DISC1 were associated with several SCZ clinical phenotypes in a Korean population. To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls. Our case-control analysis showed that none of these SNPs was associated with SCZ. In further endophenotype stratification, however, we found a significant association between rs821616 and the poor concentration subgroup of SCZ, determined using the Operational Criteria Checklist (codominant model, p=0.015). Our results suggest that DISC1 may be a susceptibility gene for poor concentration among Korean patients with SCZ.
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Jung
authors.forename: Ju Yeon
authors.initials: JY
authors.lastname: Ban
authors.forename: Jehyun
authors.initials: J
authors.lastname: Ra
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Park
authors.forename: Bong-Keun
authors.initials: BK
authors.lastname: Choe
authors.forename: Sung Vin
authors.initials: SV
authors.lastname: Yim
authors.forename: Yunhee Kim
authors.initials: YK
authors.lastname: Kwon
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins