title: [Systemic sclerosis in men].
abstract: OBJECTIVE
  To study the initial clinical features and describe the outcome of systemic sclerosis in a cohort of French men.
  
  
  METHODS
  Patients with systemic sclerosis based on Leroy's criteria were included. In this retrospective study we compared a cohort of men to a cohort of women, diagnosed between 1997 and 2005 in departments of internal medicine and rheumatology.
  
  
  RESULTS
  One hundred and twenty-one patients were included amongst which thirty-six men. The mean follow-up duration was 6.5 years. The time to diagnosis was significantly shorter in men than in women. Diffuse cutaneous systemic sclerosis, cutaneous ulcers and interstitial syndrome on chest radiograph were more frequent at diagnosis in men than in women. An environmental factor (silica) was observed in only nine men. During the follow-up, incidence of restrictive lung disease was significantly higher in men than in women (37% versus 14% p=0.01) with higher rates of oxygen dependency (22% versus 5% p<0.01). Cumulated survival rates in men were 92% at 5 years, 72% at ten years and 43% at 15 years, respectively. The mean survival was 13 years in men (IC 95%: 10-16) versus 23 years in women (IC 95%: 10-36) with no statistical difference (p=0.27).
  
  
  CONCLUSIONS
  If interstitial and restrictive lung disease, oxygen dependency and diffuse systemic sclerosis were more frequent in men than in women, this data did not provide any evidence of survival difference between men and women with systemic sclerosis.
authors.affiliation: Hospices civils de Lyon, service de médecine interne et de pathologie vasculaire, centre hospitalier Lyon Sud, 69495 Pierre-Bénite cedex, France. jean-baptiste.gaultier@chu-lyon.fr
authors.forename: J-B
authors.initials: JB
authors.lastname: Gaultier
authors.forename: A
authors.initials: A
authors.lastname: Hot
authors.forename: P
authors.initials: P
authors.lastname: Cathébras
authors.forename: C
authors.initials: C
authors.lastname: Grange
authors.forename: J
authors.initials: J
authors.lastname: Ninet
authors.forename: H
authors.initials: H
authors.lastname: Rousset
mesh_terms: D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D012737:Sex Factors; D013997:Time Factors