Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.
Baicy
Kate
K
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.
London
Edythe D
ED
Monterosso
John
J
Wong
Ma-Li
ML
Delibasi
Tuncay
T
Sharma
Anil
A
Licinio
Julio
J
D001921:Brain / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging
D020738:Leptin