title: New Ni(II)-sulfonamide complexes: synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2O)4].2H2O and [Ni(sulfapyridine)2].
abstract: The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system, space group C2/c where the nickel ion was in a slightly distorted octahedral environment, coordinated with two sulfisoxazole molecules through the heterocyclic nitrogen and four water molecules. [Ni(sulfapyridine)(2)] crystallized in a orthorhombic crystal system, space group Pnab. The nickel ion was in a distorted octahedral environment, coordinated by two aryl amine N from two sulfonamides acting as monodentate ligands and four N atoms (two sulfonamidic N and two heterocyclic N) from two different sulfonamide molecules acting as bidentate ligands. Differential pulse voltammograms were recorded showing irreversible peaks at 1040 and 1070 mV, respectively, attributed to Ni(II)/Ni(III) process. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] presented different antibacterial behavior against Staphylococcus aureus and Escherichia coli from the similar copper complexes and they were inactive against Mycobacterium tuberculosis.
authors.affiliation: Química Inorgánica, DEC, Facultad de Química, UDELAR, Gral. Flores 2124, Montevideo, Uruguay.
authors.forename: Melina
authors.initials: M
authors.lastname: Mondelli
authors.forename: Verónica
authors.initials: V
authors.lastname: Bruné
authors.forename: Graciela
authors.initials: G
authors.lastname: Borthagaray
authors.forename: Javier
authors.initials: J
authors.lastname: Ellena
authors.forename: Otaciro R
authors.initials: OR
authors.lastname: Nascimento
authors.forename: Clarice Q
authors.initials: CQ
authors.lastname: Leite
authors.forename: Alzir A
authors.initials: AA
authors.lastname: Batista
authors.forename: María H
authors.initials: MH
authors.lastname: Torre
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013427:Sulfapyridine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013444:Sulfisoxazole / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D013449:Sulfonamides; C528075:bis(sulfapyridine)nickel; C528074:tetraaquabis(sulfisoxazole)nickel; D013444:Sulfisoxazole; D009532:Nickel; D013427:Sulfapyridine