title: Synchronized delta oscillations correlate with the resting-state functional MRI signal.
abstract: Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have recently been applied to investigate large-scale neuronal networks of the brain in the absence of specific task instructions. However, the underlying neural mechanisms of these fluctuations remain largely unknown. To this end, electrophysiological recordings and resting-state fMRI measurements were conducted in alpha-chloralose-anesthetized rats. Using a seed-voxel analysis strategy, region-specific, anesthetic dose-dependent fMRI resting-state functional connectivity was detected in bilateral primary somatosensory cortex (S1FL) of the resting brain. Cortical electroencephalographic signals were also recorded from bilateral S1FL; a visual cortex locus served as a control site. Results demonstrate that, unlike the evoked fMRI response that correlates with power changes in the gamma bands, the resting-state fMRI signal correlates with the power coherence in low-frequency bands, particularly the delta band. These data indicate that hemodynamic fMRI signal differentially registers specific electrical oscillatory frequency band activity, suggesting that fMRI may be able to distinguish the ongoing from the evoked activity of the brain.
authors.affiliation: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: Hanbing
authors.initials: H
authors.lastname: Lu
authors.forename: Yantao
authors.initials: Y
authors.lastname: Zuo
authors.forename: Hong
authors.initials: H
authors.lastname: Gu
authors.forename: James A
authors.initials: JA
authors.lastname: Waltz
authors.forename: Wang
authors.initials: W
authors.lastname: Zhan
authors.forename: Clara A
authors.initials: CA
authors.lastname: Scholl
authors.forename: William
authors.initials: W
authors.lastname: Rea
authors.forename: Yihong
authors.initials: Y
authors.lastname: Yang
authors.forename: Elliot A
authors.initials: EA
authors.lastname: Stein
mesh_terms: D000818:Animals; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009415:Nerve Net; D051381:Rats