title: [The relationship between clinical outcomes of reproduc-tive abnormalities and chromosome polymorphism].
abstract: To study the relationship between chromosome polymorphism and clinical effect of reproductive abnormalities, we prepared chromosomes from peripheral blood lymphocytes and carried out G/C banding and karyotype analyses. Out of 1 414 cases who came in for genetic counseling, 273 had chromosome abnormalities. Among these 273 cases, 180 cases (65.93%) were karyotype variations, with the remaining 93 cases (34.07%) being non-polymorphic chromosomal abnormalities. Karyotype variations included 10 cases of satellite increases in the D/G group, 35 cases of secondary constriction increases, 99 cases of big or small Y chromosome, 6 cases of pericentric inversion of chromosome Y and 30 cases of pericentric inversion of chromosome 9. These results indicated that clinical effect such as abortion, sterility, stillbirth and congenital malformation are mainly related to chromosome polymorphisms.
authors.affiliation: Medical School of Yongzhou, Professional Technical College, Hunan 425000, China. yzxrw@163.com
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Wang
authors.forename: Jian-Xia
authors.initials: JX
authors.lastname: Deng
authors.forename: Jin-Jin
authors.initials: JJ
authors.lastname: Li
mesh_terms: D002869:Chromosome Aberrations; D023902:Chromosome Pairing / Q000502:physiology; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D000013:Congenital Abnormalities / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D013223:Statistics as Topic