Alchemy in the soup: transforming metabolic signals to excitability.
The intersection of cell metabolism with electrical signaling links the environment and cell function over time scales ranging from milliseconds to lifetimes. In responding to cellular metabolites, adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels are an important component of this intersection. Recent studies have begun to delineate the roles of K(ATP) channels in multiple tissues and the far-reaching consequences of aberrant K(ATP) channel activity and disturbed sensing of cell metabolism.
Nichols
Colin G
CG
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. cnichols@cellbio.wustl.edu
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D054086:KATP Channels / Q000378:metabolism; D015398:Signal Transduction
D015220:Calcium Channels; D054086:KATP Channels; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate