title: Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles.
abstract: The parent pyrrolidino[2',3':3,4]pyrrolidino[1,2-a]benzimidazole heterocycle as well as a series of novel analogues have been synthesized utilizing a microwave-assisted intramolecular cycloaddition of azomethine ylides as the key transformation. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
authors.affiliation: Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
authors.forename: Liping
authors.initials: L
authors.lastname: Meng
authors.forename: James C
authors.initials: JC
authors.lastname: Fettinger
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D001562:Benzimidazoles; D013882:Thiosemicarbazones; C512188:azomethine