[Preparation of kangfuxin colon targeting micro-pellets].
OBJECTIVE
To prepare coated micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect.


METHODS
We eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidized bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork.


RESULTS
The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets.


CONCLUSIONS
We get two micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting.
Yang
Ming
M
Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China.
Qiu
Xue-lan
XL
Xie
Xing-liang
XL
Lai
Juan
J
Chen
Si-wei
SW
D000818:Animals; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008419:Materia Medica / Q000008:administration & dosage* / Q000302:isolation & purification / Q000378:metabolism; D008747:Methylcellulose / Q000031:analogs & derivatives; D010368:Pectins; D010526:Periplaneta / Q000737:chemistry; D011109:Polymethacrylic Acids
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008419:Materia Medica; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D065347:Hypromellose Derivatives; D010368:Pectins; D008747:Methylcellulose