title: Acute coagulopathy of trauma: mechanism, identification and effect.
abstract: OBJECTIVE
  Acute coagulopathy of trauma has only been described relatively recently. Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor outcomes. This review examines the possible initiators, mechanism and clinical importance of acute coagulopathy.
  
  
  RESULTS
  Acute coagulopathy of trauma occurs in patients with shock and is characterized by a systemic anticoagulation and hyperfibrinolysis. Dilution, acidemia and consumption of coagulation proteases do not appear to be significant factors at this stage. There is evidence to implicate activation of the protein C pathway in this process. Diagnosis of acute coagulopathy currently relies on laboratory assessment of clotting times. These tests do not fully characterize the coagulopathy and have significant limitations, which reduce their clinical utility.
  
  
  CONCLUSIONS
  Acute coagulopathy results in increased transfusion requirements, incidence of organ dysfunction, critical care stay and mortality. Recognition of an early coagulopathic state has implications for the care of shocked patients and the management of massive transfusion. Identification of novel mechanisms for traumatic coagulopathy may lead to new avenues for drug discovery and therapeutic intervention.
authors.affiliation: Department of Surgery, The Royal London Hospital, London, UK. karim@trauma.org
authors.forename: Karim
authors.initials: K
authors.lastname: Brohi
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Cohen
authors.forename: Ross A
authors.initials: RA
authors.lastname: Davenport
mesh_terms: D000208:Acute Disease; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001780:Blood Coagulation Tests; D001803:Blood Transfusion; D005342:Fibrinolysis; D006801:Humans; D015601:Injury Severity Score; D011486:Protein C; D012307:Risk Factors; D012769:Shock / Q000150:complications*; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D011486:Protein C