Linkage disequilibrium and association mapping: an introduction.
The basis for recent developments on the characterization of the linkage-disequilibrium structure of the genome and the application of association mapping to genes for common human diseases is described. Patterns of linkage disequilibrium are now understood, for a number of human populations, in unprecedented detail. This information not only provides a vital resource for the design and execution of powerful association-mapping studies, but opens new avenues of research into the genetic history of human populations and the effects of natural selection, mutation, and recombination on the genomic landscape.
Collins
Andrew R
AR
Human Genetics Division, Southampton General Hospital, UK.
D002874:Chromosome Mapping / Q000379:methods*; D002892:Chromosomes, Human, Pair 22; D004194:Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008126:Lod Score; D010641:Phenotype; D011995:Recombination, Genetic