title: Comparison of diagnostic accuracy of 64-slice computed tomography coronary angiography in women versus men with angina pectoris.
abstract: We compared the diagnostic accuracy of 64-slice computed tomographic (CT) coronary angiography to detect significant coronary artery disease (CAD) in women and men. The 64-slice CT coronary angiography was performed in 402 symptomatic patients, 123 women and 279 men, with CAD prevalence of 51% and 68%, respectively. Significant CAD, defined as > or =50% coronary stenosis on quantitative coronary angiography, was evaluated on a patient, vessel, and segment level. The sensitivity and negative predictive value to detect significant CAD was very good, both for women and men (100% vs 99%, p = NS; 100% vs 98%, p = NS), whereas diagnostic accuracy (88% vs 96%; p <0.01), specificity (75% vs 90%, p <0.05), and positive predictive value (81% vs 95%, p <0.001) were lower in women. The per-segment analysis demonstrated lower sensitivity in women compared with men (82% vs 93%, p <0.001). The sensitivity in women did not show a difference in proximal and midsegments, but was significantly lower in distal segments (56% vs 85%, p <0.05) and side branches (54% vs 89%, p <0.001). In conclusion, CT coronary angiography reliably rules out the presence of obstructive CAD in both men and women. Specificity and positive predictive value of CT coronary angiography were lower in women. The sensitivity to detect stenosis in small coronary branches was lower in women compared with men.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: W Bob
authors.initials: WB
authors.lastname: Meijboom
authors.forename: Annick C
authors.initials: AC
authors.lastname: Weustink
authors.forename: Francesca
authors.initials: F
authors.lastname: Pugliese
authors.forename: Carlos A G
authors.initials: CA
authors.lastname: van Mieghem
authors.forename: Nico R
authors.initials: NR
authors.lastname: Mollet
authors.forename: Niels
authors.initials: N
authors.lastname: van Pelt
authors.forename: Filippo
authors.initials: F
authors.lastname: Cademartiri
authors.forename: Koen
authors.initials: K
authors.lastname: Nieman
authors.forename: Eleni
authors.initials: E
authors.lastname: Vourvouri
authors.forename: Eveline
authors.initials: E
authors.lastname: Regar
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: Krestin
authors.forename: Pim J
authors.initials: PJ
authors.lastname: de Feyter
mesh_terms: D000787:Angina Pectoris / Q000150:complications*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D023921:Coronary Stenosis / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012737:Sex Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*