[Case of minocycline-induced pneumonitis with bilateral pleural effusion].
A 51-year-old man was admitted to our hospital with fever, dry cough and dyspnea. He had taken minocycline for 11 days because of urinary tract infection. Chest X-ray on admission showed diffuse reticular shadows in bilateral lung fields with bilateral pleural effusion. Cessation of minocycline led to spontaneous improvement of symptoms and radiographic findings. The lymphocyte stimulation test for minocycline with peripheral blood and pleural effusion were negative. After provocation test with minocycline, he developed fever and dry cough and bilateral ground glass opacity appeared on his chest X-ray. He was diagnosed as minocycline-induced pneumonitis and recovered rapidly following corticosteroid therapy.
Arai
Satoko
S
Department of Respiratory Medicine, International Medical Center of Japan, Japan. a-satoko@dokkyomed.ac.jp
Shinohara
Yuka
Y
Kato
Yasuyuki
Y
Hirano
Satoshi
S
Yoshizawa
Atsuto
A
Hojyo
Masaaki
M
Kobayashi
Nobuyuki
N
Sugiyama
Haruhito
H
Kudo
Koichiro
K
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010996:Pleural Effusion / Q000209:etiology*; D011014:Pneumonia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D013902:Radiography, Thoracic; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D008911:Minocycline; D008775:Methylprednisolone