title: The effect of temporary aneurysm clip on the common carotid artery of atherosclerotic rabbits.
abstract: BACKGROUND
  We compared the effect of temporary aneurysm clips on atherosclerotic and nonatherosclerotic CCA of rabbits by morphometric and ultrastructural methods.
  
  
  METHODS
  The rabbits (N = 12) were divided into 2 groups: the first group was fed a 2% cholesterol diet, and the second group, a normal diet for 4 weeks. Atherosclerotic lesions developed after 4 weeks. Temporary aneurysm clips were placed on the left CCA of both groups; the right CCA of both groups served as control. Thus, a total of 4 groups were used: atherosclerotic (A), atherosclerotic/clip (AC), nonatherosclerotic (NA), and nonatherosclerotic/clip (NAC). Temporary aneurysm clips were applied for 1, 5, and 10 minutes in the AC and NAC groups. No temporary clip was placed on the right CCA (A and NA groups). The affected parts of the CCA via clips were examined under light microscope and SEM.
  
  
  RESULTS
  Comparison of atherosclerotic and nonatherosclerotic CCA of rabbits under light microscope indicated that the wall of atherosclerotic CCA was thicker than that of nonatherosclerotic CCA. The difference between the thickness of atherosclerotic and nonatherosclerotic CCAs was significant. SEM analyses showed that in nonatherosclerotic CCAs, the effect of temporary aneurysm clips was seen after 10 minutes, but in atherosclerotic CCAs, the effect was seen within the 1st minute of clipping and continued in the 5th and 10th minutes.
  
  
  CONCLUSIONS
  The duration of temporary clipping should be decreased for the neurovascular surgery of atherosclerotic patients.
authors.affiliation: Neurosurgery, Faculty of Medicine, Kocatepe University, Afyon 03200, Turkey. drcosar@hotmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Cosar
authors.forename: Ahmet Celal
authors.initials: AC
authors.lastname: Iplikcioglu
authors.forename: Nurgul
authors.initials: N
authors.lastname: Aytan
authors.forename: Deniz
authors.initials: D
authors.lastname: Ozcan
authors.forename: Tangul
authors.initials: T
authors.lastname: San
authors.forename: Nesrin
authors.initials: N
authors.lastname: Kartal-Ozer
authors.forename: Ali Fahir
authors.initials: AF
authors.lastname: Ozer
mesh_terms: D000783:Aneurysm / Q000601:surgery; D000818:Animals; D050197:Atherosclerosis / Q000473:pathology* / Q000601:surgery*; D017536:Carotid Artery, Common / Q000473:pathology* / Q000601:surgery* / Q000648:ultrastructure; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D008297:Male; D019635:Neurosurgical Procedures / Q000295:instrumentation*; D011817:Rabbits; D013997:Time Factors; D017539:Tunica Intima / Q000473:pathology / Q000648:ultrastructure