Acute Marchiafava-Bignami disease with widespread callosal and cortical lesions.
Marchiafava-Bignami disease (MBD) is a rare alcohol-related disorder that results in progressive demyelination and necrosis of the corpus callosum. The process may extend to the optic chiasm and tracts, cerebellar peduncle, subcortical resion, neighboring white matter, and rarely, cortical gray matter. We report a case of MBD in which fluid-attenuated inversion recovery and diffusion magnetic resonance imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex in addition to the callosal lesions.
Kim
Min-Jeong
MJ
Department of Neurology, Kosin University College of Medicine, Busan, Korea.
Kim
Jong-Kuk
JK
Yoo
Bong-Goo
BG
Kim
Kwang-Soo
KS
Jo
Young Duk
YD
D000437:Alcoholism / Q000150:complications; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000473:pathology; D009897:Optic Chiasm / Q000473:pathology; D012640:Seizures; D013997:Time Factors; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use
D014803:Vitamin B Complex