title: Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine.
abstract: OBJECTIVE
  To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer.
  
  
  METHODS
  A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only.
  
  
  CONCLUSIONS
  Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.
authors.affiliation: Division of General Thoracic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kawamura
authors.forename: Tai
authors.initials: T
authors.lastname: Hato
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kamiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawakubo
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Masazumi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Horinouchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy / Q000652:urine; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000188:drug therapy / Q000652:urine; D008297:Male; D009994:Osmolar Concentration; D013577:Syndrome; D014556:Urine / Q000737:chemistry; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine