title: "Mid-G" region sequences of the glycoprotein gene of Austrian infectious hematopoietic necrosis virus isolates form two lineages within European isolates and are distinct from American and Asian lineages.
abstract: Infectious hematopoietic necrosis virus (IHNV) is one of the most important pathogens of salmonid fish. In this study a comprehensive phylogenetic analysis of the genetic evolution and variety of Austrian IHNV strains, as well as selected strains ensuring worldwide coverage, is presented. The phylogenetic investigation is based on sequences comprising the "mid-G" region of the G gene, and it includes all currently available IHNV sequences of the G gene with a length of at least 615 bp. Austrian IHNVs are located--together with other European IHNV isolates--in two clusters of genogroup M (M-Eur1 and M-Eur2) and are clearly separated from American and Asian lineages. The genetic clustering, however, could not be linked to certain clinical symptoms or significant differences in the mortality rates.
authors.affiliation: Zoonoses and Emerging Infections Group, Clinical Virology, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, University of Veterinary Medicine, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kolodziejek
authors.forename: Oskar
authors.initials: O
authors.lastname: Schachner
authors.forename: Ralf
authors.initials: R
authors.lastname: Dürrwald
authors.forename: Muna
authors.initials: M
authors.lastname: Latif
authors.forename: Norbert
authors.initials: N
authors.lastname: Nowotny
mesh_terms: D000818:Animals; D001208:Asia; D001317:Austria; D016000:Cluster Analysis; D005393:Fish Diseases / Q000473:pathology / Q000821:virology*; D005399:Fishes; D019084:Fluorescent Antibody Technique, Indirect; D029142:Infectious hematopoietic necrosis virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D018353:Rhabdoviridae Infections / Q000473:pathology / Q000821:virology*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014481:United States; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: C104040:IHNVG protein, Infectious hematopoietic necrosis virus; D012367:RNA, Viral; D014759:Viral Envelope Proteins