[Jugulotympanic paraganglioma].
Jugulo-tympanic paraganglioma is the most commonly recognized neoplasia involving the middle ear, arising from chemopressure receptors. Clinical presentation is variable, with otalgia, dizziness and cranial nerve palsies. This tumor usually occurs in middle aged women and its presentation may be familiar, sporadic, bilateral or multicentric. In the present case the patients presented with otalgia and bradyacusia diagnosed with chronic otitis. A bleeding polypoid lesion in middle ear was seen during surgery. Frozen section of intraoperative specimen showed monomorphic cells organized into nests, without aspects of malignancy, into a highly vascularized stroma. Immunohistochemical analysis revealed two type of cells: chief cells immunostained for chromogranin and synaptophysin and sustentacular cells immunostained for S-100 protein. Clinical presentation of jugulotympanic paraganglioma, when it isn't associated with evidence of hormone secretion, is referred prevalently to bradyacusia, dizziness, and cranial nerve palsies. In event of localized disease, paragangliomas often can be treated by surgical excision, but some cases need radiation therapy.
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Dipartimento di Scienze Chirurgiche Università di Milano "Bicocca", U.O. Anatomia Patologica, Ospedale Civile di Vimercate, Presidio di Desio. polletta.79@libero.it
D000368:Aged; D002864:Chromogranins / Q000032:analysis; D004428:Ear Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D004432:Ear, Middle / Q000473:pathology / Q000601:surgery; D005260:Female; D005629:Frozen Sections; D005925:Glomus Jugulare Tumor / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D043604:Glomus Tympanicum Tumor / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007432:Intraoperative Period; D009418:S100 Proteins / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
D002864:Chromogranins; D009418:S100 Proteins; D016708:Synaptophysin