Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties.
Data of this study showed that alphaD-alphaE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
Amor-Mahjoub
Mouna
M
Laboratory of Biochemistry of Regulatory Signals, CNRS-University P&M Curie, 96 Bd Raspail, 75006, Paris, France. mounamor@yahoo.fr
Gomez-Vrielyunck
Nathalie
N
Suppini
Jean Philippe
JP
Fouchaq
Benoît
B
Benaroudj
Nadia
N
Ladjimi
Moncef
M
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D050883:HSC70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D020836:Protein Structure, Quaternary; D051381:Rats; D017384:Sequence Deletion; D014461:Ultracentrifugation
D050883:HSC70 Heat-Shock Proteins; C494373:Hspa8 protein, rat; D000251:Adenosine Triphosphatases