Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs.
A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.
Allen
Olivia R
OR
Department of Chemistry, University of Leeds, Leeds, UK LS2 9 JT.
Gott
Andrew L
AL
Hartley
John A
JA
Hartley
Janet M
JM
Knox
Richard J
RJ
McGowan
Patrick C
PC
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D008958:Models, Molecular; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014025:Titanium