title: Evaluation of higher order ocular aberrations in patients with keratoconus.
abstract: OBJECTIVE
  To describe higher order ocular aberrations in eyes with keratoconus.
  
  
  METHODS
  Prospective, observational, case-control study comparing higher order ocular aberrations in patients with keratoconus with control subjects with myopia.
  
  
  RESULTS
  One hundred sixteen patients with keratoconus were recruited. Data were analyzed in 35 keratoconus eyes, 38 keratoconus suspect eyes, and 166 right eyes with myopia. Mean total higher order root-mean-square (RMS) values (3rd to 5th order) were 1.73 +/- 0.71 microm in eyes with keratoconus, 0.94 +/- 0.66 microm in eyes with keratoconus suspect, and 0.49 +/- 0.16 microm in control eyes. Keratoconus eyes had greater total higher order RMS, 3rd to 5th order RMS, and RMS for all Zernike terms than those in the control group (P < .001).
  
  
  CONCLUSIONS
  Keratoconus and keratoconus suspect eyes had significantly larger higher order aberrations in total higher order RMS and 3rd order RMS than control eyes.
authors.affiliation: Singapore National Eye Centre, Singapore, PR China. lim_li@snec.com.sg
authors.forename: Li
authors.initials: L
authors.lastname: Lim
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Wei
authors.forename: Wing Kwong
authors.initials: WK
authors.lastname: Chan
authors.forename: Donald T H
authors.initials: DT
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003261:Contact Lenses; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017755:Prosthesis Fitting; D011788:Quality of Life; D012030:Refractive Errors / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology