title: Therapeutic leukocytapheresis for inflammatory bowel disease.
abstract: The inference that granulocytes and monocytes/macrophages (GM) are part of the immunopathogenesis of inflammatory bowel disease (IBD) and hence should be targets of therapy stems from observations of elevated, and activated GM in patients with IBD. The Adacolumn can selectively deplete GM by adsorption (GMA) and in patients with IBD, GMA has been associated with significant clinical efficacy together with sustained suppression of inflammatory cytokine profiles. Additionally, GMA depleted proinflammatory CD14(+)CD16(+) monocytes and was followed by an increase in CD4(+) T lymphocytes including the regulatory CD4(+)CD25(high+)Foxp3 phenotype. Hence, GMA could be a non-pharmacologic therapy for IBD with potential to spare steroids and other unsafe pharmacologic preparations.
authors.affiliation: JIMRO Laboratories, 351-1 Nishiyokote Machi, Takasaki, Japan. saniabadi@jimro.co.jp
authors.forename: Abbi R
authors.initials: AR
authors.lastname: Saniabadi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hanai
authors.forename: Ken
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Koji
authors.initials: K
authors.lastname: Sawada
authors.forename: Chikako
authors.initials: C
authors.lastname: Shima
authors.forename: Ingvar
authors.initials: I
authors.lastname: Bjarnason
authors.forename: Robert
authors.initials: R
authors.lastname: Lofberg
mesh_terms: D002448:Cell Adhesion / Q000276:immunology; D003093:Colitis, Ulcerative / Q000628:therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy*; D007937:Leukapheresis / Q000379:methods*; D007962:Leukocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology