Exhaled nitric oxide: a test for diagnosis and control of asthma?
The fractional concentration of nitric oxide (FE(NO)) in exhaled breath is a noninvasive marker of airway inflammation in asthma. The precise role of FE(NO) in the asthma management algorithm has not been defined. However, there are compelling data for use of FE(NO) for diagnosing asthma, assessing control and severity, titrating inhaled corticosteroids, and detecting ongoing airway inflammation. This article reviews the biology of nitric oxide in airway pathology and its role in asthma.
Katial
Rohit
R
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. katialR@njc.org
Stewart
Lora
L
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D009569:Nitric Oxide / Q000032:analysis* / Q000096:biosynthesis; D012016:Reference Values
D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D015415:Biomarkers; D009569:Nitric Oxide