title: Improvements in the outcome of children with meningococcal disease.
abstract: Recent years have seen a marked reduction in the mortality of children with meningococcal disease in paediatric intensive care units (PICU); the reasons for this improvement are multifactorial. The mortality rates for critically ill children overall have improved and reasons for this are probably increased centralisation of PICU services and that fewer critically ill children are now looked after on adult units. Specific treatment pathways for sepsis have improved with the publication of clinical guidelines for children and initiatives such as the Surviving Sepsis Campaign. There is a continuing need to focus on the care delivered to children before reaching PICU and to minimise the morbidity suffered by survivors of this disease.
authors.forename: Fauzia
authors.initials: F
authors.lastname: Paize
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Playfor
mesh_terms: D002648:Child; D015897:Comorbidity; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008589:Meningococcal Infections / Q000401:mortality*; D010043:Outcome and Process Assessment, Health Care; D011693:Purpura / Q000401:mortality; D018805:Sepsis / Q000401:mortality; D016019:Survival Analysis; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology