[Analysis of clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in rheumatoid arthritis (RA)].
OBJECTIVE
To examine clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in RA.


METHODS
Hundred fifteen patients with polyarthralgia (89 females, 26 males) were recruited, and subjected for the study. We studied anti-CCP antibody, ESR, CRP, IgM-RF, IgG-RF, RAPA, MMP-3, CARF, C1q-IC, Stage, Class, Joint score, Sharp score, KL-6, SP-D, chest CT.


RESULTS
Anti-CCP antibody test had high specificity (93.5%). In RA with positive anti-CCP antibody, Sharp score (10.9+/-22.4) was higher than those with negative anti-CCP (1.7+/-1.8), and may serve as a prognostic marker of joint destruction (P<0.05). Anti-CCP antibody in RA with interstitial pneumonia is higher (84.5+/-36.4 U/mL) than those without interstitial pneumonia (52.6+/-44.7 U/mL) (P<0.05).


CONCLUSIONS
Anti-CCP antibody is useful for diagnosis of RA, and could be a specific marker of joint destruction. Further investigation is necessary to clarify the relation of anti-CCP antibody with organ involvement and activity of RA.
Shimoyama
Kumiko
K
The third Department of Internal Medicine, Hamamatsu University School of Medicine.
Ogawa
Noriyoshi
N
Sakai
Tomoyuki
T
Sawaki
Toshioki
T
Kawanami
Takafumi
T
Karasawa
Hiromi
H
Masaki
Yasufumi
Y
Tanaka
Masao
M
Fukushima
Toshihiro
T
Hirose
Yuko
Y
Umehara
Hisanori
H
D018771:Arthralgia / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*
D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide