title: Development of fluorous Lewis acid-catalyzed reactions.
abstract: Organic synthetic methodology in the 21st century aims to conform to the principles of green sustainable chemistry (GSC) and we may expect that in the future, the realization of GSC will be an important objective for chemical industries. An important aim of synthetic organic chemistry is to implement waste-free and environmentally-benign industrial processes using Lewis acids as versatile as aluminum chloride. A key technological objective of our work in this area has been to achieve a "catalyst recycling system that utilizes the high activity and structural features of fluorous Lewis acid catalysts". Thus, we have developed a series of novel fluorous Lewis acid catalysts, namely the ytterbium(III), scandium(III), tin(IV) or hafnium(IV) bis(perfluoroalkanesulfonyl)amides or tris(perfluoro- alkanesulfonyl)methides. Our catalysts are recyclable and effective for acylations of alcohols and aromatics, Baeyer-Villiger reactions, direct esterifications and transesterifications in a fluorous biphasic system (FBS), in supercritical carbon dioxide and on fluorous silica gel supports.
authors.affiliation: The Noguchi Institute, Itabashi-ku, Tokyo 173-0003, Japan. ayoshida@noguchi.or.jp
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Hao
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamazaki
authors.forename: Joji
authors.initials: J
authors.lastname: Nishikido
mesh_terms: D000143:Acids / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D005466:Fluorocarbons / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000143:Acids; D005466:Fluorocarbons; D009942:Organometallic Compounds; D013449:Sulfonamides; D014867:Water; D002245:Carbon Dioxide; D058428:Silica Gel; D012822:Silicon Dioxide