title: Aminochlorination in water: first Brønsted acid-promoted synthesis of vicinal chloramines.
abstract: A practical and scaleable route for the regio- and diastereoselective synthesis of vicinal chloramines from electron-deficient olefins and Chloramine-T promoted by Brønsted acids in water has been realized for the first time. This novel protocol is efficient, mild, ecofriendly, and broadly applicable for the aminochlorination of various electron-deficient olefins including alpha,beta-unsaturated ketones, cinnamate, and cinnamide. Water represents as a privileged solvent for the aminochlorination reaction in our system.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Joint Laboratory of Green Synthetic Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, PR China.
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Wu
authors.forename: Guan-Wu
authors.initials: GW
authors.lastname: Wang
mesh_terms: D000143:Acids / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D000586:Amination; D002700:Chloramines / Q000138:chemical synthesis*; D002712:Chlorides / Q000737:chemistry*; D002934:Cinnamates / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008956:Models, Chemical; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D000143:Acids; D000577:Amides; D002700:Chloramines; D002712:Chlorides; D002934:Cinnamates; D007659:Ketones; D012997:Solvents; D014867:Water