title: LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.
abstract: LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.
authors.affiliation: Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands.
authors.forename: Herfita
authors.initials: H
authors.lastname: Agustiandari
authors.forename: Jacek
authors.initials: J
authors.lastname: Lubelski
authors.forename: H Bart
authors.initials: HB
authors.lastname: van den Berg van Saparoea
authors.forename: Oscar P
authors.initials: OP
authors.lastname: Kuipers
authors.forename: Arnold J M
authors.initials: AJ
authors.lastname: Driessen
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis*; D004269:DNA, Bacterial / Q000378:metabolism; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology*; D013294:Lactococcus lactis / Q000235:genetics / Q000502:physiology*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D011485:Protein Binding; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D004269:DNA, Bacterial; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012097:Repressor Proteins; C513418:LmrC protein, Lactococcus lactis; C513419:LmrD protein, Lactococcus lactis