[Endoscopic, clinicopathologic and immunohistochemical features of gastric stromal tumor].
OBJECTIVE
For gastric stromal tumor (GST), the low incidence and high diversity in endoscopic and pathologic manifestations lead to misdiagnosis. This study was to explore the features of GST in endoscopy and clinicopathology.


METHODS
Clinical data of 42 GST patients, treated at the Second Affiliated Hospital of Sun Yat-sen University from Jan. 1996 to Jan. 2006, were analyzed for their clinicopathologic and endoscopic features. The expression of CD117, CD34, smooth muscle actin (SMA), Desmin and S-100 were detected by immunohistochemistry. Their correlations to clinicopathologic features of GST were analyzed.


RESULTS
Of the 42 cases of GST, 21 (50.0%) were at the fundus, 14 (33.3%) at the body, and 7 (16.7%) at the antrum; 17 (40.5%) were benign, 14 (33.3%) borderline, 11 (26.2%) malignant. Endoscopically, GST presented submucosal hemispheroid or polypoid protuberant lesions with clear border. While the positive rate of gastroendoscopic biopsy was low. Of the 42 cases, 29 were spindle cell type, 5 were epithelial cell type, and 8 were mixed type. The positive rates of CD34 and CD117 were 92.86% and 78.57%.


CONCLUSIONS
GST has unique morphologic features. Combined detection of CD117 and CD34 benefits the diagnosis of GST.
Huang
Kai-Hong
KH
Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China. huangkaih@21cn.com
Liu
Jian-Hua
JH
Wang
Ling-Yun
LY
Wang
Lian-Yuan
LY
Li
Chu-Qiang
CQ
Zhu
Zhao-Hua
ZH
Li
Hai-Gang
HG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate
D018952:Antigens, CD34; D019009:Proto-Oncogene Proteins c-kit