title: Progressive multifocal leukoencephalopathy as first manifestation of sarcoidosis.
abstract: Progressive multifocal leukoencephalopathy (PML) is a demyelinating neurologic disorder caused by a polyomavirus, called JC virus. PML affects mainly immunocompromised hosts. We report a case of PML as first manifestation of sarcoidosis in a previously healthy man. Treatment with cidofovir, resulted in a neurological and radiological stabilization. To our knowledge the association of PML and sarcoidosis without previous immunosuppressive treatment has only been described in a few cases, none of them were treated with cidofovir.
authors.affiliation: Department of Neurology UZ Brussel, Brussels, Belgium. Sylvie.deraedt@uzbrussel.be
authors.forename: Sylvie
authors.initials: S
authors.lastname: De Raedt
authors.forename: Patrick
authors.initials: P
authors.lastname: Lacor
authors.forename: Alex
authors.initials: A
authors.lastname: Michotte
authors.forename: Anja
authors.initials: A
authors.lastname: Flamez
authors.forename: Guy
authors.initials: G
authors.lastname: Ebinger
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir