Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder.
OBJECTIVE
Posttraumatic stress disorder (PTSD) and panic disorder (PD) are two anxiety disorders with prominent psychophysiological symptoms. The PTSD criterion of persistent hyperarousal suggests autonomic dysregulation, and the disorder has been associated with elevated heart rate. In contrast, PD has been associated with respiratory abnormalities such as low end-tidal Pco(2). An integrated analysis of automatic and respiratory function in a direct comparison of these anxiety disorders is currently lacking.


METHODS
Electrodermal, cardiovascular, and respiratory psychophysiology was examined in 23 PTSD patients, 26 PD patients, and 32 healthy individuals at baseline and during threat of shock.


RESULTS
At baseline, the PTSD patients, in contrast to the other two groups, were characterized by attenuated parasympathetic and elevated sympathetic control, as evidenced by low respiratory sinus arrhythmia (a measure of cardiac vagal control) and high electrodermal activity. They also displayed elevated heart rate and cardiovascular sympathetic activation in comparison with healthy controls. PD patients exhibited lower Pco(2) (hypocapnia) and higher cardiovascular sympathetic activation compared with healthy controls. PTSD patients, but not PD patients, sighed more frequently than controls. During the threat of shock phase, the PTSD group demonstrated blunted electrodermal responses.


CONCLUSIONS
Persistent hyperarousal symptoms in PTSD seem to be due to high sympathetic activity coupled with low parasympathetic cardiac control. Respiratory abnormalities were also present in PTSD. Several psychophysiological measures exhibited group-comparison effect sizes in the order of 1.0, supporting their potential for enhancing differential diagnosis and possibly suggesting utility as endophenotypes in genetic studies of anxiety disorders.
Blechert
Jens
J
Department of Clinical Psychology and Psychotherapy, University of Basel, Missionsstrasse 60/62, CH-4055 Basel, Switzerland.
Michael
Tanja
T
Grossman
Paul
P
Lajtman
Marta
M
Wilhelm
Frank H
FH
D000328:Adult; D000379:Agoraphobia / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D001008:Anxiety Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D001143:Arousal / Q000502:physiology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood*; D003130:Combat Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D004562:Electrocardiography; D004597:Electroshock / Q000523:psychology; D005239:Fear / Q000502:physiology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D016857:Hypocapnia / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology / Q000523:psychology; D016584:Panic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010698:Phobic Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D011602:Psychophysiologic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012016:Reference Values; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology
D002245:Carbon Dioxide