[Study on the characteristic of Surveillance Creutzfeldt-Jakob disease patients from January to August in 2006 in China].
OBJECTIVE
To describe the incidence condition and characteristic of Creutzfeldt-Jakob disease (CJD) in China.


METHODS
The clinical and epidemical information of patients from China CJD surveillance network was analyzed. Blood and cerebrospinal fluid (CSF) specimens from these patients were differently collected to be used to detect the 14-3-3 protein in the CSF and to analyze the PRNP gene.


RESULTS
Ten possible and 8 probable clinically diagnosed CJD patients were found. These patients had sporadic CJD. There were no geographic clustering and occupational risk with these patients. The mean age at onset of disease was approximately 60 years. The male to female ratio was approximately 1:1; rapidly progressive dementia was the main early symptom, which was present in 44% of patients.


CONCLUSIONS
The geographic distribution, occupation, the ratio of male to female and the mean age of onset were consistent with the characteristics of sporadic CJD.
Gao
Chen
C
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Beijing, China.
Han
Jun
J
Zhou
Wei
W
Chen
Jian-Ming
JM
Shi
Qi
Q
Zhang
Bao-Yun
BY
Xiang
Ni-Juan
NJ
Gao
Yong-Jun
YJ
Dong
Xiao-Ping
XP
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000328:Adult; D000368:Aged; D015153:Blotting, Western; D002681:China / Q000453:epidemiology; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics
D048948:14-3-3 Proteins; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions