Diverse functions of VDUP1 in cell proliferation, differentiation, and diseases.
Vitamin D3 up-regulated protein 1 (VDUP1) is a multifunctional protein involved in maintaining cellular homeostasis. VDUP1 is induced by a variety of stresses. Inversely, VDUP1 is often reduced in various tumor tissues and cell lines. Over-expression of VDUP1 inhibits cell proliferation through cell cycle arrest. VDUP1 interacts with thioredoxin (Trx) and negatively regulates the expression and antioxidant function of Trx which is involved in redox regulation. VDUP1-/- mice are more susceptible to carcinogenesis than wild-type mice and are defective in establishing immune system including the development and function of natural killer cells. Furthermore, VDUP1-/- mice show impaired Kreb cycle-mediated fatty acid utilization. In this review, we have discussed the multifunctional roles of VDUP1 in diverse cellular responses, in particular its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases.
Kim
Sang Yong
SY
Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305-333, Republic of Korea.
Suh
Hyun-Woo
HW
Chung
Jin Woong
JW
Yoon
Suk-Ran
SR
Choi
Inpyo
I
D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002762:Cholecalciferol / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D009369:Neoplasms / Q000378:metabolism*; D010084:Oxidation-Reduction; D013879:Thioredoxins / Q000502:physiology*
D002352:Carrier Proteins; C486715:TXNIP protein, human; C445672:Txnip protein, mouse; D002762:Cholecalciferol; D013879:Thioredoxins