title: Primary central nervous system malignant melanoma: report of 5 cases.
abstract: Primary melanocytic neoplasms of the central nervous system consist of a spectrum of lesions ranging from well-differentiated melanocytoma to its overtly malignant counterpart, melanoma. Clinicopathologic features of 5 cases of primary central nervous system malignant melanoma were studied to define histologic appearances, diagnostic criteria, and the clinical behavior of lesions along this spectrum. There were three women and two men (mean age was 35 years) with symptoms of increased intracranial pressure. Radiological findings showed a solitary intra parenchymal lesion with variable enhancement after gadolinium administration. All patients underwent surgical treatment. Histologic examination revealed primary melanoma.
authors.affiliation: Department of Pathology, Hospital La Rabta, 1007 Bab Saadoun, Tunis. aminamekninouira@yahoo.fr
authors.forename: A
authors.initials: A
authors.lastname: Mekni
authors.forename: E
authors.initials: E
authors.lastname: Braham
authors.forename: K
authors.initials: K
authors.lastname: Nouira
authors.forename: K
authors.initials: K
authors.lastname: Ben Hammouda
authors.forename: K
authors.initials: K
authors.lastname: Bellil
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: N
authors.initials: N
authors.lastname: Kchir
authors.forename: M
authors.initials: M
authors.lastname: Khaldi
authors.forename: M
authors.initials: M
authors.lastname: Zitouna
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000473:pathology