Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones.
The reaction of the internal alkynyl ketones 1 (n=1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n=0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.
Jin
Tienan
T
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Yamamoto
Yoshinori
Y