title: Hepatocellular carcinoma and congenital absence of the portal vein in a child receiving growth hormone therapy for turner syndrome.
abstract: Turner syndrome patients are reported to have no increase in the relative risk of cancer, and hepatocellular carcinoma in particular has never been reported in this syndrome. However, Turner syndrome patients are known to have an increased prevalence of liver lesions, some of which, like focal nodular hyperplasia, are related to vascular anomalies. We report the case of a young patient with Turner syndrome, treated with recombinant human growth hormone, who was found to have absence of the portal vein, focal nodular hyperplasia, and hepatic adenoma and who developed a large hepatocellular carcinoma requiring liver transplant.
authors.affiliation: Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA. raffaella.morotti@mountsinai.org
authors.forename: Raffaella A
authors.initials: RA
authors.lastname: Morotti
authors.forename: Mary
authors.initials: M
authors.lastname: Killackey
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Shneider
authors.forename: Anthony
authors.initials: A
authors.lastname: Repucci
authors.forename: Sukru
authors.initials: S
authors.lastname: Emre
authors.forename: Swan N
authors.initials: SN
authors.lastname: Thung
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis*; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis*; D011169:Portal Vein / Q000002:abnormalities*; D014424:Turner Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D019382:Human Growth Hormone