Adoptive cellular immunotherapy for viral diseases.
Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.
Fujita
Y
Y
Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.
Rooney
C M
CM
Heslop
H E
HE
D002648:Child; D004266:DNA Virus Infections / Q000209:etiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D013602:T-Lymphocytes, Cytotoxic / Q000637:transplantation*; D017735:Virus Latency