[Prospective study of early application of immune-enhanced enteral nutrition and recombined human growth hormone on patients with gastric neoplasms after total gastrectomy].
OBJECTIVE
To explore the effect of immune-enhanced enteral nutrition (IEN) together with recombined human growth hormone (rhGH) on patients after total gastrectomy.


METHODS
Forty-eight patients after total gastrectomy were randomly divided into EN group (n=16), IEN group (n=16) and IEN+ rhGH(n=16) group. Nitrogen balance, nutritional status, immune function and lassitude degree were compared among 3 groups.


RESULTS
IEN+rhGH group had better efficacy as compared to EN and IEN group in improving postoperative nutritional status, immune function, nitrogen balance and lassitude degree, and recovered to normal level after 7 days. All the indexes of IEN+rhGH group except CD8 were improved significantly on the 10th day after operation as compared to those of EN group[total protein(66.8 +/- 2.0)g/L vs (65.8 +/- 0.9)g/L, CD3(66.1 +/- 6.3)% vs (60.5 +/- 5.6)%, Christensen score (4.6 +/- 0.9) vs (6.3 +/- 0.9), all P<0.05].


CONCLUSIONS
Early application of IEN combined with rhGH plays an effective role in improving protein metabolism and immune function for patients after total gastrectomy in short period.
Lu
Bei
B
Department of General Surgery, The First People's Hospital of Hangzhou, Hangzhou, China.
Cai
Yang
Y
Feng
Guang-Hua
GH
Luo
Zhong-Yao
ZY
Zhu
Wei
W
Ni
Jie
J
Zhang
Xi-Ping
XP
D000368:Aged; D004750:Enteral Nutrition / Q000379:methods*; D005217:Fat Emulsions, Intravenous; D005260:Female; D005743:Gastrectomy; D019382:Human Growth Hormone / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000628:therapy*
D005217:Fat Emulsions, Intravenous; D011994:Recombinant Proteins; D019382:Human Growth Hormone