Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person.
Recent studies on psychoneuroimmunology have indicated that positive psychological events are related to immune functions; however, limited information is available regarding associations among the central nervous, endocrine, and immune systems when positive emotions are elicited. In the present study, we demonstrated associations among these systems by simultaneously recording brain, endocrine, and immune activities when positive emotions were evoked in participants as they watched films featuring their favorite persons. Interestingly, the activity of peripheral circulating natural killer cells and the peripheral dopamine level were elevated while participants experienced positive emotions, and these values were positively correlated. The following brain regions were significantly activated in the positive condition relative to the control condition: medial prefrontal cortex, thalamus, hypothalamus, subcallosal gyrus, posterior cingulate cortex, superior temporal gyrus, and cerebellum. Further, covariate analyses indicated that these brain regions were temporally associated with endocrine and immune activities. These results suggest that while an individual experiences positive emotions, the central nervous, endocrine, and immune systems may be interrelated and attraction for favorite persons may be associated with the activation of the innate immune function via the dopaminergic system.
Matsunaga
Masahiro
M
Department of Psychology, Graduate School of Environmental Studies, Nagoya University, Aichi, Japan. matsunag@aichi-med-u.ac.jp
Isowa
Tokiko
T
Kimura
Kenta
K
Miyakoshi
Makoto
M
Kanayama
Noriaki
N
Murakami
Hiroki
H
Sato
Sayaka
S
Konagaya
Toshihiro
T
Nogimori
Tsuyoshi
T
Fukuyama
Seisuke
S
Shinoda
Jun
J
Yamada
Jitsuhiro
J
Ohira
Hideki
H
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D004298:Dopamine / Q000097:blood; D004644:Emotions / Q000502:physiology*; D004702:Endocrine Glands / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007694:Killer Cells, Natural / Q000502:physiology; D008297:Male; D009040:Motion Pictures; D049268:Positron-Emission Tomography
D004298:Dopamine