Evolution of the endoplasmic reticulum and the Golgi complex.
By analyzing the morpho-physiological features of the Golgi complex, its relationship with the endoplasmic reticulum in different species, and the molecular machineries involved in intracellular transport, we conclude that; (1) all eukaryotic cells have either Golgi complexes or remnants thereof; (2) all eukaryotic cells have a large minimal set of proteins that are involved in intracellular transport; and (3) several indispensable molecular machines are always present in secreting eukaryotic cells. Using this information, our data about mechanisms of intra-Golgi transport and phylogenetic analysis of several molecular machines, we propose a model for the evolution of the Golgi complex and the endoplasmic reticulum.
Mironov
Alexander A
AA
Department of Cell Biology and Oncology, Mario Negri Sud Institute, Via Nazionale 8, 66030 Santa Maria Imbaro, Chieti, Italy. mironov@negrisud.it
Banin
Victor V
VV
Sesorova
Irina S
IS
Dolgikh
Viacheslav V
VV
Luini
Alberto
A
Beznoussenko
Galina V
GV
D000818:Animals; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology; D019143:Evolution, Molecular; D006056:Golgi Apparatus / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological; D050600:SNARE Proteins / Q000235:genetics / Q000378:metabolism
D050600:SNARE Proteins