title: A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan.
abstract: BACKGROUND
  The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.
  
  
  METHODS
  In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms' association with gastric cancer susceptibility.
  
  
  RESULTS
  We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47-9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.
  
  
  CONCLUSIONS
  Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
authors.affiliation: Department of Hematology Oncology, China Medical University Hospital, Taichung, Taiwan, ROC.
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Wang
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Wang
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Nan-Yung
authors.initials: NY
authors.lastname: Hsu
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Weng
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan
chemical_list: D004268:DNA-Binding Proteins; C101467:XRCC4 protein, human