title: Steroid responsiveness of children with idiopathic nephrotic syndrome in southeastern region of Turkey.
abstract: BACKGROUND
  Our aim was to determine the prognostic factors effective in the response to steroid treatment and relapse frequency.
  
  
  METHODS
  In this study, we evaluated 84 children with idiopathic nephrotic syndrome followed-up from 1997-2002. The variables were analyzed with respect to medical history, physical examination, laboratory findings, response to treatment, and factors associated with remissions and relapses. Our study group consisted of 62 children with minimal change nephrotic syndrome (MCNS), 11 children with focal segmental glomerulosclerosis (FSGS), and 11 children with diffuse mesangial proliferation (DMP).
  
  
  RESULTS
  According to response to steroids; 57.1% were steroid-sensitive with infrequent relapses, 22.6% were steroid-dependent with frequent relapses, and 20.2% were steroid-non-responders. Significantly high non-responder ratios to steroids were found in children with initial hypertension and hematuria (p < 0.05). Although patients older than six years were found to be associated with steroid non-response (p < 0.05), the number of relapses were found to be increased with an increasing number of infections (p < 0.05). The time period for the first relapse was found to be statistically correlated with relapse numbers of the first 6 (p = 0.001) and 12 (p = 0.01) months.
  
  
  CONCLUSIONS
  The time span between initial presentation and remission and the number of infections were significant for relapse frequency. The existence of hematuria and hypertension and age greater than 6 years at initial presentation were associated with steroid non-responsiveness. The likelihood of developing resistance to the treatment should be emphasized early to the parents of patients bearing these risk factors, and hence the possible disappointment in the family should be prevented.
authors.affiliation: Department of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey. drmdavutoglu@hotmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Davutoglu
authors.forename: Aydin
authors.initials: A
authors.lastname: Ece
authors.forename: Meki
authors.initials: M
authors.lastname: Bilici
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dagli
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D011241:Prednisone