title: Lipid and lipoprotein profiles and prevalence of dyslipidemia in Mexican adolescents.
abstract: The objective of the study was to determine the prevalence of different forms of dyslipidemia in an urban population of Mexican adolescents. A cross-sectional study was conducted in 1846 students from 8 randomly selected public junior high schools in Mexico City. Anthropometry, blood pressure, and 12-hour fasting lipids and lipoproteins were measured. We studied 770 male and 1076 female adolescents (13.2 +/- 1 years). The most prevalent dyslipidemia was low high-density lipoprotein cholesterol (HDL-C) (<35 mg/dL) either combined with other abnormalities (17.5% for male and 12.9% for female subjects, P < .001) or isolated (13.5% and 9.6% for male and female subjects, respectively, P < .001). Obese subjects showed the highest prevalence of low HDL-C (47.2% for male and 34.4% for female subjects) and of high total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) (19.4%, 27.8%, and 36.1%, respectively, for male subjects; 9.8%, 13.1%, and 24.6%, respectively, for female subjects). Multiple regression analysis showed that waist circumference was negatively associated with HDL-C and positively associated with LDL-C and TG levels, whereas Tanner stages were negatively associated but sex was positively associated with total cholesterol, LDL-C, and TG concentrations. As in Mexican adults, low HDL-C and high TG levels were the most prevalent dyslipidemias. Increased blood lipids over long periods suggest that, as adults, these adolescents will be facing a higher risk for atherosclerosis.
authors.affiliation: Departamento de Endocrinología del Instituto Nacional de Cardiología Ignacio Chávez. Tlalpan, Mexico City, Mexico, DF 14080, Mexico. rossy_posadas_s@yahoo.it
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.forename: José
authors.initials: J
authors.lastname: Zamora-González
authors.forename: Enrique
authors.initials: E
authors.lastname: Mendoza-Pérez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Cardoso-Saldaña
authors.forename: Liria
authors.initials: L
authors.lastname: Yamamoto-Kimura
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology* / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D015995:Prevalence; D012907:Smoking / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014505:Urban Population
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides