title: Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.
abstract: Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
authors.forename: Sampada
authors.initials: S
authors.lastname: Karkare
authors.forename: Eba
authors.initials: E
authors.lastname: Adou
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy
authors.initials: P
authors.lastname: Brodie
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: N M
authors.initials: NM
authors.lastname: Andrianjafy
authors.forename: J
authors.initials: J
authors.lastname: Razafitsalama
authors.forename: Rabodo
authors.initials: R
authors.lastname: Andriantsiferana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D010946:Plants, Medicinal / Q000737:chemistry*; D030013:Strophanthus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D006027:Glycosides