title: The effect of milk protein on the bioavailability of cocoa polyphenols.
abstract: In order to determine whether milk proteins interact with cocoa polyphenols to modulate the uptake and concentration of polyphenols in plasma, 24 middle-aged men and women consumed 2 g of chocolate polyphenols, plus sugar and cocoa butter in 200 mL water, on 2 occasions. On 1 occasion, the chocolate mix contained 2.45 g of milk proteins. Blood samples were taken fasting and at regular intervals for 8 h. Catechin and epicatechins levels were measured in these samples and no differences were seen in average concentrations between the 2 treatments. Milk protein caused a slight increase in concentration at the early time points and a decrease at the later time points. In conclusion, milk powder did not influence the average concentration of polyphenols. While it slightly accelerated absorption, this is of no physiological significance.
authors.affiliation: CSIRO Human Nutrition, PO Box 10041 Adelaide BC, South Australia 5000, Australia. jennifer.keogh@csiro.au
authors.forename: J B
authors.initials: JB
authors.lastname: Keogh
authors.forename: J
authors.initials: J
authors.lastname: McInerney
authors.forename: P M
authors.initials: PM
authors.lastname: Clifton
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001682:Biological Availability; D002099:Cacao / Q000737:chemistry*; D002392:Catechin / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000494:pharmacology*; D010636:Phenols / Q000493:pharmacokinetics*; D059808:Polyphenols
chemical_list: D005419:Flavonoids; D008894:Milk Proteins; D010636:Phenols; D059808:Polyphenols; D002392:Catechin