Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses.
Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
Haldar
Jayanta
J
Department of Chemistry and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chen
Jianzhu
J
Tumpey
Terrence M
TM
Gubareva
Larisa V
LV
Klibanov
Alexander M
AM
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D053139:Oseltamivir / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000494:pharmacology; D053243:Zanamivir / Q000494:pharmacology*
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; C525941:N,N-dodecyl,methyl-polyethylenimine; D053139:Oseltamivir; D011094:Polyethyleneimine; D053243:Zanamivir