Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework.
The synthesis of pharmaceutically active compounds bearing a disubstituted piperidine framework is reviewed. Due to their frequent occurrence in pharmaceutical research, functionalized piperidines and the synthetic methodologies used for their preparation are of considerable topical interest. The present review focuses on the synthetic pathways used for the preparation of disubstituted piperidines and also briefly covers the activity and/or usage of the same.
Källström
Sara
S
Laboratory of Organic Chemistry, Abo Akademi University, FI-20500 Abo, Finland.
Leino
Reko
R
D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D010880:Piperidines