Nevirapine-associated rash with eosinophilia and systemic symptoms in a child with human immunodeficiency virus infection.
Drug rash with eosinophilia and systemic symptoms (DRESS Syndrome) associated with nevirapine treatment has not been previously reported in children. These findings can mimic other common illnesses, and treatment options are limited. We describe a 12-year-old girl infected with human immunodeficiency virus who developed hypersensitivity to nevirapine therapy. She was successfully treated with intravenous immune globulin.
Santos
Roberto P
RP
Department of Pediatrics, Division of Infectious Disease, University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, USA. Roberto.Santos@UTSouthwestern.edu
Ramilo
Octavio
O
Barton
Theresa
T
D019380:Anti-HIV Agents / Q000009:adverse effects*; D002648:Child; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D019829:Nevirapine / Q000009:adverse effects*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D013577:Syndrome
D019380:Anti-HIV Agents; D016756:Immunoglobulins, Intravenous; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine