title: Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes.
abstract: Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive cyclopropanation-Cope rearrangement affords novel chemotypes including spiroindane frameworks.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Sarathy
authors.initials: S
authors.lastname: Kesavan
authors.forename: James S
authors.initials: JS
authors.lastname: Panek
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D000478:Alkylation; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D007189:Indans; D013141:Spiro Compounds; D014753:Vinyl Compounds; C093582:indan