title: Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp.
abstract: The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Rama
authors.initials: R
authors.lastname: Addepalli
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001315:Australia; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D058919:Purinergic P2 Receptor Antagonists; D058486:Receptors, Purinergic P2X7; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D003603:Cytotoxins; C546468:P2RX7 protein, human; D058919:Purinergic P2 Receptor Antagonists; D058486:Receptors, Purinergic P2X7; C525432:psammaplysene C; C525433:psammaplysene D; D014443:Tyrosine