title: Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels.
abstract: OBJECTIVE
  The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients.
  
  
  METHODS
  Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinical practice. Demographic data and concomitant medications were recorded from the patient medical file.
  
  
  RESULTS
  Sixty patients were included in the study; 30 patients were treated with CBZ and 30 with OXCBZ. Median Hcy level was significantly higher in CBZ-treated patients (20.6 micromol/l) than in OXCBZ-treated patients (14.0 micromol/l, p < 0.0001). No correlation was evidenced between antiepileptic drugs or metabolite levels and Hcy levels for each group.
  
  
  CONCLUSIONS
  Less change observed with OXCBZ compared with CBZ on aminothiol levels could constitute an advantage for OXCBZ treatment in patients with other factors influencing Hcy levels and/or at high risk for cardiovascular diseases.
authors.affiliation: Laboratoire de Biochimie, Hôpital Lapeyronie, Montpellier Cedex 5, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Badiou
authors.forename: Hélène
authors.initials: H
authors.lastname: Breton
authors.forename: Hélène
authors.initials: H
authors.lastname: Peyriere
authors.forename: Virginie
authors.initials: V
authors.lastname: Charasson
authors.forename: Arielle
authors.initials: A
authors.lastname: Crespel
authors.forename: Philippe
authors.initials: P
authors.lastname: Gelisse
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Dominique
authors.initials: D
authors.lastname: Hillaire-Buys
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000150:complications; D003545:Cysteine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D004151:Dipeptides; D006710:Homocysteine; D002220:Carbamazepine; C028505:cysteinylglycine; D003545:Cysteine; D000078330:Oxcarbazepine