title: Rheumatoid arthritis association at 6q23.
abstract: The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).
authors.affiliation: Arthritis Research Campaign (arc)-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.
authors.forename: Wendy
authors.initials: W
authors.lastname: Thomson
authors.forename: Anne
authors.initials: A
authors.lastname: Barton
authors.forename: Xiayi
authors.initials: X
authors.lastname: Ke
authors.forename: Steve
authors.initials: S
authors.lastname: Eyre
authors.forename: Anne
authors.initials: A
authors.lastname: Hinks
authors.forename: John
authors.initials: J
authors.lastname: Bowes
authors.forename: Rachelle
authors.initials: R
authors.lastname: Donn
authors.forename: Deborah
authors.initials: D
authors.lastname: Symmons
authors.forename: Samantha
authors.initials: S
authors.lastname: Hider
authors.forename: Ian N
authors.initials: IN
authors.lastname: Bruce
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Wilson
authors.forename: Ioanna
authors.initials: I
authors.lastname: Marinou
authors.forename: Ann
authors.initials: A
authors.lastname: Morgan
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
authors.forename: Angela
authors.initials: A
authors.lastname: Carter
authors.forename: Sophia
authors.initials: S
authors.lastname: Steer
authors.forename: Lynne
authors.initials: L
authors.lastname: Hocking
authors.forename: David M
authors.initials: DM
authors.lastname: Reid
authors.forename: Paul
authors.initials: P
authors.lastname: Wordsworth
authors.forename: Pille
authors.initials: P
authors.lastname: Harrison
authors.forename: David
authors.initials: D
authors.lastname: Strachan
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22