Parkinsonism in a patient with antiphospholipid syndrome--case report and literature review.
Antiphospholipid syndrome (APS) is identified as the presence of antiphospholipid antibodies (aPLs) in patients with vascular thrombosis and/or pregnancy morbidity (including fetal death, premature birth and habitual abortion). Neurological manifestations in patients with APS are common, whereas movement disorders are rarely seen. We report an extremely rare case of APS presented with parkinsonism and review the literature to address the clinical profile and possible pathophysiologic mechanism of this disorder.
Huang
Yen-Chu
YC
Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine 199 Tung Hwa North Road, Taipei, 10591, Taiwan.
Lyu
Rong-Kuo
RK
Chen
Sien-Tsong
ST
Chu
Yi-Chuan
YC
Wu
Yih-Ru
YR
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015140:Dementia, Vascular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D000978:Antiparkinson Agents; D007980:Levodopa; D014859:Warfarin