title: Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea.
abstract: Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, was isolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystal X-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and was synthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AChE) and two tumor cell lines (K562 and A549) were also evaluated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Suo
authors.initials: S
authors.lastname: Gao
authors.forename: Fu-Mei
authors.initials: FM
authors.lastname: Yang
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Sun
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000143:Acids / Q000737:chemistry; D000470:Alkaloids / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D031422:Hosta / Q000737:chemistry*; D015394:Molecular Structure; D010627:Phenethylamines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000143:Acids; D000470:Alkaloids; D010627:Phenethylamines; C526096:hostasinine A; D001554:Benzene