title: Developing a tissue perfusion sensor.
abstract: The development of a electrochemical tissue perfusion sensor is presented. The sensor is a platinum/platinum ring-disc microelectrode that relies on the principle of collector-generator to monitor mass transport within its vicinity. Tissue perfusion is a mass transport mechanism that describes the movement of respiratory gases, nutrients and metabolites in tissue. The sensor's capability of detecting perfusion at the cellular level in a continuous fashion is unique. This sensor will provide insight into the way nutrients and metabolites are transported in tissue especially in cases were perfusion is low such as in wounds or ischemic tissue. We present experimental work for the development and testing of the sensors in vitro. Experimental flow recordings in free steam solutions as well as the flow through tissue-like media are shown. Tests on post operative human tissue are also presented. The sensor's feature such as the continuous recoding capacities, spatial resolution and the measurement range from ml/min to microl/min are highlighted.
authors.affiliation: Department of Bioengineering, Imperial College London, London, UK.
authors.forename: S L R
authors.initials: SL
authors.lastname: Harvey
authors.forename: K H
authors.initials: KH
authors.lastname: Parker
authors.forename: D
authors.initials: D
authors.lastname: O'Hare
mesh_terms: D001692:Biological Transport; D004058:Diffusion; D004563:Electrochemistry; D006801:Humans; D008839:Microelectrodes; D012867:Skin / Q000098:blood supply / Q000378:metabolism*