Ingenane diterpenoids from Euphorbia esula.
An extensive study of metabolites present in Euphorbia esula led to isolation of 16 ingenane diterpenoids 1-16 together with the known ingenane derivative 17 and four known cycloartane triterpenoids. Their structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. All the compounds were assayed for their inhibitory activity against human HeLa cervical cancer cell line.
Lu
Zhi-Qiang
ZQ
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Guo Shoujing Road 199, Zhangjiang, Shanghai 201203, PR China.
Yang
Min
M
Zhang
Jin-Qiang
JQ
Chen
Guang-Tong
GT
Huang
Hui-Lian
HL
Guan
Shu-Hong
SH
Ma
Chao
C
Liu
Xuan
X
Guo
De-An
DA
D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
D004224:Diterpenes; C530110:ingenane