title: Direct one-pot synthesis of alpha-siloxy-Weinreb amides from aldehydes.
abstract: A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.
authors.affiliation: Department of Pharmaceutical Chemistry, Division of Health Biosciences, Graduate School of The University of Tokushima, 1-78-1, Tokushima, Japan 770-8505. nem@ph.tokushima-u.ac.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Nemoto
authors.forename: Rujian
authors.initials: R
authors.lastname: Ma
authors.forename: Hideki
authors.initials: H
authors.lastname: Moriguchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawamura
authors.forename: Masaki
authors.initials: M
authors.lastname: Kamiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shibuya
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D000577:Amides