Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine.
OBJECTIVE
To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer.


METHODS
A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only.


CONCLUSIONS
Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.
Kuroda
Hiroaki
H
Division of General Thoracic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kawamura
Masafumi
M
Hato
Tai
T
Kamiya
Kazunori
K
Kawakubo
Masahiro
M
Izumi
Yotaro
Y
Watanabe
Masazumi
M
Horinouchi
Hirohisa
H
Kobayashi
Koichi
K
Nakayama
Mitsuo
M
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy / Q000652:urine; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000188:drug therapy / Q000652:urine; D008297:Male; D009994:Osmolar Concentration; D013577:Syndrome; D014556:Urine / Q000737:chemistry; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine