The role of the woodchuck model in the treatment of hepatitis B virus infection.
Experimental studies of animals with chronic hepadnavirus infection could provide valuable insight into optimal therapeutic strategies for individuals with chronic HBV infection. In this review, we focus on the contributions of the woodchuck model to our understanding of HBV biology and on its role in the development of antiviral drug. Furthermore, we consider the implications of studies focusing on the natural history of WHV infection for the management of HBV and the capacity of treatment to prevent complications of chronic hepatitis B infection.
Kulkarni
Ketan
K
Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, 1305 York Avenue, 4th floor, New York, NY 10021, USA.
Jacobson
Ira M
IM
Tennant
Bud C
BC
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D004195:Disease Models, Animal; D006509:Hepatitis B / Q000188:drug therapy / Q000628:therapy / Q000821:virology*; D017919:Hepatitis B Virus, Woodchuck / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology; D008392:Marmota
D000998:Antiviral Agents; D004279:DNA, Viral