title: Heart fatty acid binding protein and myoglobin after reperfusion of acute myocardial infarction.
abstract: OBJECTIVE
  The aim of this study was to disclose the release kinetics of heart fatty acid binding protein (HFABP) and myoglobin in acute myocardial infarction (AMI) reperfused by primary percutaneous coronary intervention (PPCI) and to determine the influence of the quality of coronary flow post PPCI on the release properties of these markers.
  
  
  RESULTS
  Twenty-four patients with AMI who underwent successful PPCI and had no evidence of reocclusion within the first 120 minutes were studied. Serum myoglobin and HFABP levels at baseline and at 15, 30, 45, 60, 90 and 120 minutes after reperfusion were measured. Corrected TIMI frame count (CTFC) in the relevant vessel post PPCI was used to categorize patients in group I (CTFC > 21) and group 2 (CTFC < or = 21). Biomarker ratios at each sampling point were calculated by dividing the serum level of the biomarker at the specific sampling time by its baseline level. Baseline myoglobin and HFABP levels rose significantly at 15 minutes (153 +/- 251.5 microg/L vs. 904.3 +/- 542.6 microg/L, 10.9 +/- 8 microg/L vs. 17.8 +/- 9.1 microg/L, both P < 0.0001) after successful PPCI. Group 2 patients tended to have higher biomarker ratios at each time point as compared to group I.
  
  
  CONCLUSIONS
  Successful PPCI for AMI results in a significant increase of both HFABP and myoglobin levels within 15 minutes of vessel opening and the quality of flow in the infarction-related artery post PCI as evaluated by CTFC does not influence the release kinetics of these biomarkers.
authors.affiliation: Department of Cardiology, Gazi University School of Medicine, Beşevler, Ankara, Turkey. hozdemir@gazi.edu.tr
authors.forename: Murat
authors.initials: M
authors.lastname: Ozdemir
authors.forename: Emre
authors.initials: E
authors.lastname: Durakoğlugil
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gülbahar
authors.forename: Sedat
authors.initials: S
authors.lastname: Turkoglu
authors.forename: Banu
authors.initials: B
authors.lastname: Sancak
authors.forename: Hatice
authors.initials: H
authors.lastname: Paşaoğlu
authors.forename: Atiye
authors.initials: A
authors.lastname: Cengel
mesh_terms: D000208:Acute Disease; D015415:Biomarkers; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000502:physiology*; D005227:Fatty Acids / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D009206:Myocardium; D009211:Myoglobin / Q000502:physiology*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009211:Myoglobin