title: Radiological aid to clinical diagnosis of Schnitzler's syndrome: multimodality imaging approach.
abstract: Schnitzler's syndrome is a rare combination of chronic urticaria, fever of unknown origin, disabling bone pain, and monoclonal gammopathy. We report a case with an unusual radiological manifestation as a solitary sclerotic lesion of the right iliac bone. Its main features on conventional radiography, computed tomography, and magnetic resonance imaging are described, and the main radiological differential diagnoses are discussed to help with the characterization of this syndrome, which requires a combination of clinical, laboratory, and radiological data. On the other hand, although our patient had an excellent clinical response to anakinra, the sclerotic lesion remained unchanged on follow-up X-ray examinations.
authors.affiliation: Department of Diagnostic Radiology, Faculty of Medicine, University Hospital Marqués de Valdecilla (HUMV), University of Cantabria, Avda. Valdecilla no. 25, 39008, Santander, Cantabria, Spain. alejandrofernandezflorez@hotmail.com
authors.forename: Alejandro Fernández
authors.initials: AF
authors.lastname: Flórez
authors.forename: Elena
authors.initials: E
authors.lastname: Gallardo Agromayor
authors.forename: Rosario
authors.initials: R
authors.lastname: García-Barredo
authors.forename: Rosa Ma
authors.initials: RM
authors.lastname: Landeras Alvaro
authors.forename: Miren
authors.initials: M
authors.lastname: Gorriño Angulo
authors.forename: Victor Manuel
authors.initials: VM
authors.lastname: Martínez-Taboada
authors.forename: Ma Antonia
authors.initials: MA
authors.lastname: Fernández Echevarría
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003952:Diagnostic Imaging / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy / Q000473:pathology; D019873:Schnitzler Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014581:Urticaria / Q000188:drug therapy / Q000473:pathology
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D008727:Methotrexate