Neonatal diabetes.
ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic Beta-cells KATP channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of type 2 diabetes. This review discusses recent advances in our understanding of the role of KATP channels in permanent neonatal diabetes mellitus.
Tammaro
Paolo
P
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
D003920:Diabetes Mellitus / Q000151:congenital* / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology; D054086:KATP Channels / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D009154:Mutation
D054086:KATP Channels