Diabetes mellitus in the 21 years after a pregnancy that was complicated by hypertension: findings from a prospective cohort study.
OBJECTIVE
The purpose of this study was to examine the relationship between hypertensive disorders of pregnancy (HDP) and self-reported diabetes mellitus 21 years after delivery.


METHODS
The Mater-University of Queensland Study is a prospective cohort study of women who received antenatal care at a major public hospital in Brisbane, Australia, between 1981 and 1984; 3639 women who completed the questionnaire at 21 years postpartum were included.


RESULTS
Of the women without HDP, 7.4% reported a diagnosis of diabetes mellitus compared with 15.3% of the women with HDP (unadjusted odds ratio [OR], 2.03; 95% CI, 1.42, 2.91). After adjustment for all potentially explanatory variables, only prepregnancy body mass index (BMI) and BMI at 21 years after delivery resulted in attenuation of the association (fully adjusted OR, 1.76; 95% CI, 1.21, 2.56). In a smaller subgroup, waist circumference and BMI at 21 years had similar effects on point estimates (fully adjusted OR with BMI, 1.64 [95% CI, 1.11, 2.42]; fully adjusted OR with waist, 1.60 [95% CI, 1.08, 2.40]).


CONCLUSIONS
HDP are associated with reported diagnosis of diabetes mellitus 21 years after delivery.
Callaway
Leonie K
LK
Department of Internal Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Australia.
Lawlor
Debbie A
DA
O'Callaghan
Michael
M
Williams
Gail M
GM
Najman
Jake M
JM
McIntyre
H David
HD
D000328:Adult; D015992:Body Mass Index; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology* / Q000503:physiopathology; D007333:Insulin Resistance; D008423:Maternal Age; D015999:Multivariate Analysis; D016017:Odds Ratio; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011446:Prospective Studies; D018570:Risk Assessment; D012907:Smoking / Q000453:epidemiology; D013997:Time Factors