PC-1 genotype and IRS response to exercise training.
The purpose of this study was to investigate whether the efficacy of exercise training as a means of insulin resistance syndrome (IRS) treatment is dependent on the PC-1 gene K121Q variants. A population of 84 abdominally obese Korean women was analyzed prospectively. Before and after a 12-week exercise (walking) training program, indices of body fatness including body mass index, percent body fat, and waist circumference, and cardiorespiratory fitness were measured. Total cholesterol (TC), triacylglycerol, high-density lipoprotein cholesterol (HDLC), glucose, and insulin were measured in fasting venous blood. At baseline, KK individuals had significantly lower waist circumference (p = 0.019) and TC (p = 0.001) than KQ/QQ individuals did. In particular, compared with KQ/QQ individuals, KK individuals had significantly greater reductions in body weight (p = 0.002), BMI (p = 0.032), and fasting insulin (p = 0.042), and a greater increase in HDLC (p = <0.001), following the 12-week walking exercise program. This study suggests that the PC-1 gene K121Q polymorphism may modulate responses of IRS to exercise training, at least in this population.
Park
S
S
School of Sport Science, Sungkyunkwan University, Jangan-Gu, Suwon, Republic of Korea.
Han
T
T
Son
T
T
Kang
H-S
HS
D000328:Adult; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D007723:Korea; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000534:rehabilitation; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D011446:Prospective Studies; D011755:Pyrophosphatases / Q000235:genetics*; D013577:Syndrome; D049629:Waist-Hip Ratio
D008076:Cholesterol, HDL; D007328:Insulin; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases