title: Pharmacological fMRI--challenges in analysing drug-induced single-event BOLD responses.
abstract: The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.
authors.affiliation: Neurology & GI Centre of Excellence in Drug Discovery, GlaxoSmithKline R&D Ltd., Harlow, CM19 5AW, UK. andreas.x.pohlmann@gsk.com
authors.forename: Andreas
authors.initials: A
authors.lastname: Pohlmann
authors.forename: Hervé
authors.initials: H
authors.lastname: Barjat
authors.forename: Lorna C
authors.initials: LC
authors.lastname: Tilling
authors.forename: Michael F
authors.initials: MF
authors.lastname: James
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations; D010100:Oxygen