Transient parvovirus-associated hypoplasia of multiple peripheral blood cell lines in children with chronic hemolytic anemia.
Human parvovirus infection typically causes transient red blood cell aplasia. However, contrary to common perceptions, the hematopathologic effects of parvovirus infection are not always limited to the erythroid lineage. We describe here a consecutive series of 17 patients with chronic hemolytic anemia hospitalized for aplastic crisis, of whom 13 had transient hypoplasia of multiple peripheral blood cell lines.
Cauff
Brian E
BE
Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Quinn
Charles T
CT
D000741:Anemia, Aplastic / Q000473:pathology / Q000821:virology*; D000743:Anemia, Hemolytic / Q000473:pathology / Q000821:virology*; D001773:Blood Cells / Q000473:pathology / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D010322:Parvoviridae Infections / Q000473:pathology / Q000503:physiopathology*; D017992:Parvovirus