Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis.
Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare disease characterized by autoantibodies to the alpha 3 chain of type IV collagen in the GBM. It is also known as Goodpasture's syndrome when associated with pulmonary hemorrhage due to autoantibodies to the alpha 3 chain of type IV collagen also present in pulmonary alveoli. Even more rare is the evolution of anti-GBM GN into membranous nephropathy (MN). We report the management of a 9-year-old Caucasian girl with anti-GBM GN that evolved into MN and briefly review the literature.
Hecht
Natalie
N
Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton, OH, USA.
Omoloja
Abiodun
A
Witte
Dave
D
Canessa
Leonardo
L
D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications*; D002648:Child; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000209:etiology*; D006801:Humans