title: Effects of isomeric fatty acids on reproductive parameters in mice.
abstract: OBJECTIVE
  The aim of this study was to determine if dietary fatty acids (FA) level or isomeric FA type may affect reproductive parameters in mice.
  
  
  METHODS
  of study Mice were fed for 1 month diets differing in cisFA (cFA) content or type of isomeric FA. Resorption, number of fetuses and placental cytokine expression were determined and sperm acrosome reaction was evaluated after induction by calcium ionophore.
  
  
  RESULTS
  Mice fed high fat diets showed increased fetal resorptions, a decrease in interleukin (IL)-4 placental expression in the first generation and an increase of tumor necrosis factor-alpha (TNF-alpha) in the second generation. In this generation, conjugated linoleic acid (CLA) returned TNF-alpha to normal levels and diminished IL-4 and transforming growth factor-beta (TGF-beta) expressions; males fed transFA (tFA) and CLA showed a lower rate of induced acrosome reaction.
  
  
  CONCLUSIONS
  The amount and type of dietary FA may affect reproductive performance in mice by affecting sperm membrane functionality and placental cytokine production.
authors.affiliation: Cátedra de Inmunología Básica, Facultad de Bioquímica y Ciencias Biológicas de la Universidad Nacional del Litoral, Santa Fe, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Veaute
authors.forename: María Florencia
authors.initials: MF
authors.lastname: Andreoli
authors.forename: Andrea
authors.initials: A
authors.lastname: Racca
authors.forename: Alejandra
authors.initials: A
authors.lastname: Bailat
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Scalerandi
authors.forename: Claudio
authors.initials: C
authors.lastname: Bernal
authors.forename: Ileana
authors.initials: I
authors.lastname: Malan Borel
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005227:Fatty Acids / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005327:Fetal Resorption / Q000209:etiology / Q000378:metabolism; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D007536:Isomerism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000276:immunology; D012098:Reproduction / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects; D053781:Transforming Growth Factor beta2 / Q000096:biosynthesis / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D053781:Transforming Growth Factor beta2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4