title: Fat-saturated diffusion-weighted imaging of the rat pelvis using three-dimensional MP-RAGE MR sequence.
abstract: In this work we report on the development of a novel technique for fat-saturated three-dimensional (3D) diffusion-weighted (DW) MRI sequence based upon 3D magnetization-prepared rapid gradient-echo (3D-MP-RAGE). In order to saturate fat, two kinds of procedures were competed CHESS-DW-3D-MP-RAGE sequence (CHESS-3D-DWI) and DW-3D-MP-WE-RAGE sequence (WE-3D-DWI) "chemical shift selective: CHESS method vs. water-excitation: WE method". The CHESS-3D-DWI sequence and WE-3D-DWI sequence were compared in terms of their degree of fat suppression. In CHESS-3D-DWI sequence a preparation phase with a "CHESS-90 degrees RF-motion probing gradient: MPG-180 degrees RF-MPG-90 degrees RF" pulse-train was used to sensitize the magnetization to fat-saturated diffusion. In contrast, WE-3D-DWI sequence a RAGE-excitation pulse with a "binominal-pulse 1-1 or 1-2-1" was selected to water-excited (fat-saturated) diffusion imaging. These imaging were done during in vivo studies using an animal experiment. From experimental results obtained with a phantom, the effect of diffusion weighting and the effect of fat-saturation were confirmed. Fat-saturation was much better in the WE-3D-DWI sequence than CHESS-3D-DWI sequence. From rat experimental results, fat-saturated diffusion-weighted image data were obtained. This sequence was useful for in vivo imaging.
authors.affiliation: Dept. of Radiological Science, Tokyo Metropolitan University, Tokyo, Japan. t-numano@post.metro-hs.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Numano
authors.forename: K
authors.initials: K
authors.lastname: Homma
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Hyodo
authors.forename: N
authors.initials: N
authors.lastname: Nitta
mesh_terms: D000818:Animals; D049628:Body Size; D001835:Body Weight; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional; D045170:Matrix Attachment Regions; D008953:Models, Anatomic; D010388:Pelvis / Q000473:pathology*; D019047:Phantoms, Imaging; D051381:Rats; D012680:Sensitivity and Specificity