[Mechanisms of progression of renal disease--part I (cellular biology)].
After sufficient damage of the total functional renal mass, the kidney has inclination toward deterioration long after the disappearance of the initial insult. The pathogenetic mechanisms of this process are numerous. However, they slowly began to be better characterized. The main factors thought to be responsible for the progression of the renal disease concern resting and infiltrating glomerular cells. In the first part of the review mechanisms of action of these cells are discussed. Once activated glomerular resting and infiltrating cells secrete numerous cytokines which can initiate and perpetuate injury of the glomerular basement membrane, and increase synthesis of mesangial matrix that leads to glomerular sclerosis. In the second part of the review (to be published) the additional renal and extrarenal risk factors involved in the progression of the renal disease will be discussed.
Popović-Polović
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D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000166:cytology / Q000503:physiopathology