Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression.
Fibroblast growth factor-7 (FGF7) is a lung epithelial cell mitogen that is cytoprotective during injury. Transgenic mice that conditionally expressed FGF7 were used to dissect the mechanisms of FGF7 protection during lung injury. FGF7 improved survival when induced 3 days prior to acute lung injury. In contrast, FGF7 caused pulmonary inflammation and lung injury after 7 days or longer. Gene expression analysis of mouse lung mRNA identified mRNAs that contribute to the protective effects of FGF7. FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression.
Tichelaar
Jay W
JW
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. Jay.Tichelaar@uc.edu
Wesselkamper
Scott C
SC
Chowdhury
Supurna
S
Yin
Hulian
H
Berclaz
Pierre-Yves
PY
Sartor
Maureen A
MA
Leikauf
George D
GD
Whitsett
Jeffrey A
JA
D000818:Animals; D019610:Cytoprotection; D004847:Epithelial Cells / Q000502:physiology; D051523:Fibroblast Growth Factor 7 / Q000032:analysis / Q000502:physiology*; D020869:Gene Expression Profiling; D007249:Inflammation / Q000209:etiology*; D008168:Lung / Q000166:cytology*; D051379:Mice; D008822:Mice, Transgenic; D009532:Nickel / Q000633:toxicity; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D012128:Respiratory Distress Syndrome / Q000517:prevention & control; D013997:Time Factors
C496454:Fgf7 protein, mouse; D011506:Proteins; D012333:RNA, Messenger; C470307:UGRP2 protein, mouse; D051523:Fibroblast Growth Factor 7; D009532:Nickel