title: Rabeprazole- versus esomeprazole-based eradication regimens for H. pylori infection.
abstract: BACKGROUND
  Different kinds of proton pump inhibitor-based triple therapies could result in different Helicobacter pylori eradication rates.
  
  
  OBJECTIVE
  The aims of this study were to compare the efficacy and safety of rabeprazole- and esomeprazole-based triple therapy in primary treatment of H. pylori infection in Taiwan.
  
  
  METHODS
  From June 2005 to March 2007, 420 H. pylori-infected patients were randomly assigned to receive a 7-day eradication therapy with either esomeprazole 40 mg daily (EAC group, n = 209) or rabeprazole 20 mg b.i.d. (RAC group, n = 211) in combination with amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d.. Follow-up endoscopy with biopsy was done 12-16 weeks after completion of eradication therapy. Those who refused endoscopic exams underwent (13)C-urea breath test to assess the treatment response.
  
  
  RESULTS
  Intention-to-treat analysis revealed that the eradication rate was 89.4% in the EAC group and 90.5% in RAC groups (p-value = .72). All of the subjects returned for assessment of compliance (100% in EAC group vs. 99.5% in RAC group, p-value = .32) and adverse events (3.83% in EAC group vs. 6.16% in RAC group, p-value = .27). Sixty (28.7%) and 37 (17.6%) patients in EAC and RAC group, respectively, refused endoscopy and underwent a (13)C-urea breath test to determine the treatment effect.
  
  
  CONCLUSIONS
  In conclusion, rabeprazole- and esomeprazole-based primary therapies for H. pylori infection are comparable in efficacy and safety.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: I-Chen
authors.initials: IC
authors.lastname: Wu
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lu
authors.forename: Fang-Jung
authors.initials: FJ
authors.lastname: Yu
authors.forename: Tsang-En
authors.initials: TE
authors.lastname: Wang
authors.forename: Wen-Hsiung
authors.initials: WH
authors.lastname: Chang
authors.forename: Jyh-Jon
authors.initials: JJ
authors.lastname: Chen
authors.forename: Fu-Chen
authors.initials: FC
authors.lastname: Kuo
authors.forename: Jeng-Yih
authors.initials: JY
authors.lastname: Wu
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Wang
authors.forename: Ming-Jong
authors.initials: MJ
authors.lastname: Bair
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017291:Clarithromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D064098:Esomeprazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D064750:Rabeprazole
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D000658:Amoxicillin; D017291:Clarithromycin; D064098:Esomeprazole