title: Post-irradiation angiosarcoma of bone.
abstract: Radiation therapy is extensively used for treatment of malignancies, but angiosarcomas occurring in an irradiated area are uncommon. We report a rare case of high-grade epithelioid angiosarcoma of upper end of right humerus in a 67-year-old male occurring ten years following irradiation for giant cell tumor of the same anatomical site. The patient presented with progressive painful swelling over right shoulder and his X-ray showed erosion of medial cortex with lytic areas at upper end of humerus. He underwent excision of affected part of humerus followed by cemented hemiarthroplasty and bone grafting. After initial histopathological diagnostic dilemma the final report was given as post-radiation angiosarcoma. Disease recurred at the end of one-year follow-up period where upon he underwent wide resection with prosthesis replacement. He received four cycles of combination chemotherapy with doxorubicin and ifosfamide and currently is free of recurrence after six months follow-up.
authors.affiliation: Department of Medical Oncology, B P Poddar Hospital and Medical Research Ltd, Kolkata, India. rinkumittal@rediffmail.com
authors.forename: Srabani
authors.initials: S
authors.lastname: Mittal
authors.forename: Chanchal
authors.initials: C
authors.lastname: Goswami
authors.forename: Nandini
authors.initials: N
authors.lastname: Kanoria
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Bhattacharya
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome