title: [Expression of coxsackie B virus-adenovirus receptor in prostate cancer Du145 and LNCaP cell lines and its significance].
abstract: OBJECTIVE
  To observe the expression of Coxsackie B virus-adenovirus receptor (CAR) in two prostate cancer cell lines with different metastatic potentials.
  
  
  METHODS
  The expressions of CAR in two prostate cancer cell lines (Du145 and LNCaP) with different metastatic potentials were detected by Western blotting. The Transwell polycarbonate filter was used to analyze the invasive potency.
  
  
  RESULTS
  As one of the adhesion associated proteins, CAR highly expressed in the LNCaP cell line, which is well known with a low metastatic potential, and lowly expressed in Du145 with a high metastatic potential (P < 0.01). The invasive potency of Du145 was significantly higher than that of LNCaP (P < 0.05).
  
  
  CONCLUSIONS
  There was a difference in the metastatic phenotypes of CAR among cell lines with different metastatic potentials. The expressions of CAR proteins may play an important role in repressing the metastasis of prostate cancer.
authors.affiliation: Department of Urology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China. luoyongxjtu@sohu.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Yong-Guang
authors.initials: YG
authors.lastname: Jiang
authors.forename: Da-Lin
authors.initials: DL
authors.lastname: He
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Zhang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Hou
authors.forename: Ming-Chuan
authors.initials: MC
authors.lastname: Li
mesh_terms: D015153:Blotting, Western; D045744:Cell Line, Tumor; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D011991:Receptors, Virus / Q000378:metabolism*
chemical_list: C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus