title: Maternal nodal and zebrafish embryogenesis.
abstract: In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway. Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.
authors.affiliation: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Bennett
authors.forename: Heather L
authors.initials: HL
authors.lastname: Stickney
authors.forename: Wen-Yee
authors.initials: WY
authors.lastname: Choi
authors.forename: Brian
authors.initials: B
authors.lastname: Ciruna
authors.forename: William S
authors.initials: WS
authors.lastname: Talbot
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Schier
mesh_terms: D000818:Animals; D019521:Body Patterning; D004625:Embryo, Nonmammalian / Q000378:metabolism; D005260:Female; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009035:Mothers; D055456:Nodal Signaling Ligands; D010053:Ovary / Q000378:metabolism; D010063:Ovum / Q000378:metabolism; D012326:RNA Splicing; D015203:Reproducibility of Results; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D055456:Nodal Signaling Ligands; D029961:Zebrafish Proteins; C485171:ndr1 protein, zebrafish; C512832:ndr2 protein, zebrafish