title: [Intercellular adhesion molecule-1 expression in renal cell carcinoma].
abstract: The presence of intercellular adhesion molecule-1 (ICAM-1) was analyzed using indirect immunoperoxidase technique in frozen sections of 27 renal cell carcinomas (RCC)--18 clear cell, 6 granular, 2 chromophobe and 1 sarcomatoid. Great variations in ICAM-1 expression were observed in clear and granular cell RCC, without correlation with mononuclear (lympho-monocytic) cell infiltration. Sarcomatoid type displayed widespread ICAM-1 distribution and intense mononuclear infiltrate, while chromophobic RCC, despite better prognosis, expressed ICAM-1 weakly and focally, almost without mononuclear infiltrate. With such results, no relation between ICAM-1 expression on tumor cells and behavior of various RCC types could be established and possible explanations are: different histogenesis of some RCC (chromophobe), nonspecific upregulation of ICAM-1 as a result of ischaemic-necrotic processes, or negative effect of ICAM-1 expression on complement action.
authors.forename: D
authors.initials: D
authors.lastname: Brasanac
authors.forename: K
authors.initials: K
authors.lastname: Radotić-Smiljanić
authors.forename: G
authors.initials: G
authors.lastname: Basta-Jovanović
authors.forename: S
authors.initials: S
authors.lastname: Tatić
authors.forename: J
authors.initials: J
authors.lastname: Marković-Lipkovski
mesh_terms: D002292:Carcinoma, Renal Cell / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D007680:Kidney Neoplasms / Q000737:chemistry*
chemical_list: D018799:Intercellular Adhesion Molecule-1