title: Parental transmission of HLA-DRB1*15 in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors.forename: Sreeram V
authors.initials: SV
authors.lastname: Ramagopalan
authors.forename: Blanca M
authors.initials: BM
authors.lastname: Herrera
authors.forename: Jordana T
authors.initials: JT
authors.lastname: Bell
authors.forename: David A
authors.initials: DA
authors.lastname: Dyment
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: Deluca
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Lincoln
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Orton
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Chao
authors.forename: A Dessa
authors.initials: AD
authors.lastname: Sadovnick
authors.forename: George C
authors.initials: GC
authors.lastname: Ebers
mesh_terms: D002648:Child; D015331:Cohort Studies; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010290:Parents
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C507799:HLA-DRB1*15 antigen