title: [A patient with Churg-Strauss syndrome presenting as Guillain-Barré syndrome].
abstract: A 74-year-old man presented in a pulmonary clinic with symmetrically ascending tetraparesis. Physical and neurophysiological examinations suggested Guillain-Barré syndrome. The patient was treated with an initial course of 7s immunoglobulins without success. His state worsened until he was unable to walk. Severe eosinophilia (41%) was later noted in the differential white blood cell count. Combined with the onset of asthma-like symptoms, this prompted us to suspect Churg-Strauss syndrome. Despite treatment with high-dose corticoids, the palsy did not improve. It was only after immunosuppression with cyclophosphamide that the patient began to recover. The subgroup of necrotising vasculitides must be considered as differential diagnosis of rapidly progressive, symmetrical neuropathy with ascending course. Early identification and treatment are essential, since early immunosuppressive therapy is often successful, whereas delayed initiation of treatment may lead to a fatal outcome.
authors.affiliation: Klinik für Neurologie, Georg-August-Universität, Robert-Koch-Strasse 40, 37075, Göttingen, Deutschland. mdjukic@gwdg.de
authors.forename: M
authors.initials: M
authors.lastname: Djukic
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Mazurek
authors.forename: F
authors.initials: F
authors.lastname: König
authors.forename: S
authors.initials: S
authors.lastname: Schweyer
authors.forename: R
authors.initials: R
authors.lastname: Nau
mesh_terms: D001249:Asthma / Q000150:complications; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000473:pathology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009297:Nasal Mucosa / Q000473:pathology; D009460:Neurologic Examination; D012852:Sinusitis / Q000150:complications; D013497:Sural Nerve / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide