title: Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo.
abstract: In vivo high-resolution peripheral quantitative micro-CT (HR-pQCT) is a new modality for imaging peripheral sites like the distal tibia and the distal radius, providing structural bone parameters. Comparing HR-pQCT with MRI, we found that both modalities are capable of offering meaningful information on trabecular structure.
  
  
  BACKGROUND
  Magnetic resonance imaging (MRI) has emerged as the leading in vivo method for measuring trabecular bone micro-architecture and providing structural information. Recently, an in vivo HR-pQCT modality was introduced for imaging peripheral sites like the distal tibia and the distal radius, providing structural bone parameters. The goal of this work was to compare and evaluate the performances and in vivo capabilities of HR-pQCT in comparison with MRI at 3 Tesla.
  
  
  METHODS
  To this end images of 8 human specimens (5 tibiae and 3 radii) and 11 participants (6 tibia and 5 radii) were acquired with both modalities. Additionally, the radius specimens were scanned with micro-CT (muCT), which was used as a standard of reference. Structural parameters calculated from MRI were compared with results from HR-pQCT images and additionally muCT for the radii specimens.
  
  
  RESULTS
  High correlations (r > 0.7) were found for trabecular number and trabecular spacing between the two modalities in vivo and ex vivo. 2D and 3D analysis revealed high correlations (r > 0.8) in structural bone parameters for all measurements. Using micro-CT as standard of reference both results from QCT and MRI correlated well.
  
  
  CONCLUSIONS
  Both imaging modalities were found to perform equally well regarding trabecular bone measurements.
authors.affiliation: Department of Radiology, University of California, San Francisco, CA, USA. Roland.Krug@mrsc.ucsf.edu
authors.forename: R
authors.initials: R
authors.lastname: Krug
authors.forename: J
authors.initials: J
authors.lastname: Carballido-Gamio
authors.forename: A J
authors.initials: AJ
authors.lastname: Burghardt
authors.forename: G
authors.initials: G
authors.lastname: Kazakia
authors.forename: B H
authors.initials: BH
authors.lastname: Hyun
authors.forename: B
authors.initials: B
authors.lastname: Jobke
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: M
authors.initials: M
authors.lastname: Huber
authors.forename: T M
authors.initials: TM
authors.lastname: Link
authors.forename: S
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000473:pathology*; D012015:Reference Standards; D015203:Reproducibility of Results; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards