title: [Analysis of clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in rheumatoid arthritis (RA)].
abstract: OBJECTIVE
  To examine clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in RA.
  
  
  METHODS
  Hundred fifteen patients with polyarthralgia (89 females, 26 males) were recruited, and subjected for the study. We studied anti-CCP antibody, ESR, CRP, IgM-RF, IgG-RF, RAPA, MMP-3, CARF, C1q-IC, Stage, Class, Joint score, Sharp score, KL-6, SP-D, chest CT.
  
  
  RESULTS
  Anti-CCP antibody test had high specificity (93.5%). In RA with positive anti-CCP antibody, Sharp score (10.9+/-22.4) was higher than those with negative anti-CCP (1.7+/-1.8), and may serve as a prognostic marker of joint destruction (P<0.05). Anti-CCP antibody in RA with interstitial pneumonia is higher (84.5+/-36.4 U/mL) than those without interstitial pneumonia (52.6+/-44.7 U/mL) (P<0.05).
  
  
  CONCLUSIONS
  Anti-CCP antibody is useful for diagnosis of RA, and could be a specific marker of joint destruction. Further investigation is necessary to clarify the relation of anti-CCP antibody with organ involvement and activity of RA.
authors.affiliation: The third Department of Internal Medicine, Hamamatsu University School of Medicine.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Shimoyama
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ogawa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sakai
authors.forename: Toshioki
authors.initials: T
authors.lastname: Sawaki
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kawanami
authors.forename: Hiromi
authors.initials: H
authors.lastname: Karasawa
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Masaki
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hisanori
authors.initials: H
authors.lastname: Umehara
mesh_terms: D018771:Arthralgia / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide