title: Plasma angiogenin levels in acute coronary syndromes: implications for prognosis.
abstract: OBJECTIVE
  Angiogenin is a member of the ribonuclease superfamily, which has been implicated as a mitogen of endothelial cells and activator of matrix metalloproteinases and plasminogen-activated plasmin pathways. We hypothesized abnormalities of angiogenin levels in acute coronary syndrome (ACS), with prognostic implications for predicting adverse events.
  
  
  RESULTS
  We measured plasma angiogenin levels (ELISA) in 396 consecutive patients (63.4% males; mean age 67 years, SD 13) admitted with ACS, who were compared with 44 'disease controls' (patients with stable coronary artery disease) and 76 healthy controls. Clinical follow-up at 6 months was performed for adverse endpoints (cardiovascular death, recurrent ACS, revascularization and heart failure). ACS patients had significantly elevated plasma angiogenin levels compared with both disease controls and healthy controls (P < 0.001). After adjusting for baseline characteristics, raised troponin T levels and electrocardiographic changes, raised angiogenin levels were independently associated with more adverse events at 6 months' follow-up [HR 1.44 (95% CI: 1.10-1.89); P = 0.008].
  
  
  CONCLUSIONS
  Plasma angiogenin levels are significantly increased in ACS, and may be involved in the pathogenesis of this condition. High angiogenin levels were predictive of adverse events during follow-up.
authors.affiliation: Cardiology Department, Hospital General Universitario, Alicante, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tello-Montoliu
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.forename: Jeetesh
authors.initials: J
authors.lastname: Patel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Roldán
authors.forename: Luis
authors.initials: L
authors.lastname: Mainar
authors.forename: Vicente
authors.initials: V
authors.lastname: Vicente
authors.forename: Francisco
authors.initials: F
authors.lastname: Sogorb
authors.forename: Gregory Y H
authors.initials: GY
authors.lastname: Lip
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012259:Ribonuclease, Pancreatic / Q000097:blood*; D020107:Troponin T / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D020107:Troponin T; D042461:Vascular Endothelial Growth Factor A; C046366:angiogenin; D012259:Ribonuclease, Pancreatic