Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis.
BACKGROUND
Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels; however, these drugs have certain limitations which cause serious and sometimes fatal consequences. Herbal preparations have been used since ancient times for the treatment of several diseases. Herbs and their components possessing antithrombotic activity have been reported before; however, herbs that could be used for thrombolysis has not been reported so far. This study's aim was to investigate whether herbal preparations (aqueous extract) possess thrombolytic activity or not.


METHODS
An in vitro thrombolytic model was used to check the clot lysis effect of six aqueous herbal extracts viz., Tinospora cordifolia, Rubia cordifolia, Hemidesmus indicus, Glycyrrhiza glabra Linn, Fagonia Arabica and Bacopa monnieri Linn along with Streptokinase as a positive control and water as a negative control.


RESULTS
Using an in vitro thrombolytic model, Tinospora cordifolia, Rubia cordifolia, Hemidesmus indicus, Glycyrrhiza glabra Linn, Fagonia Arabica and Bacopa monnieri Linn showed 19.3%, 14.5%, 20.3%, 17.8%, 75.6% and 41.8% clot lysis respectively . Among the herbs studied Fagonia arabica showed significant % of clot lysis (75.6%) with reference to Streptokinase (86.2%).


CONCLUSIONS
Through our study it was found that Dhamasa possesses thrombolytic properties that could lyse blood clots in vitro; however, in vivo clot dissolving properties and active component(s) of Dhamasa for clot lysis are yet to be discovered. Once found Dhamasa could be incorporated as a thrombolytic agent for the improvement of patients suffering from Atherothrombotic diseases.
Prasad
Sweta
S
Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2, Bajaj Nagar, Nagpur-440010, Maharashtra, India. sweta_ciims@yahoo.com
Kashyap
Rajpal Singh
RS
Deopujari
Jayant Y
JY
Purohit
Hemant J
HJ
Taori
Girdhar M
GM
Daginawala
Hatim F
HF
D001777:Blood Coagulation / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006035:Glycyrrhiza; D031102:Hemidesmus; D006801:Humans; D066298:In Vitro Techniques; D008517:Phytotherapy / Q000379:methods*; D010946:Plants, Medicinal; D045470:Rubia; D013927:Thrombosis / Q000188:drug therapy*; D031610:Tinospora; D016896:Treatment Outcome; D028461:Zygophyllaceae
D005343:Fibrinolytic Agents