title: Distal embolic protection for renal arterial interventions.
abstract: Distal or embolic protection has intuitive appeal for its potential to prevent embolization of materials generated during interventional procedures. Distal protection devices (DPDs) have been most widely used in the coronary and carotid vascular beds, where they have demonstrated the ability to trap embolic materials and, in some cases, to reduce complications. Given the frequency of chronic kidney disease in patients with renal artery stenosis undergoing stent placement, it is reasonable to propose that these devices may play an important role in limiting distal embolization in the renal vasculature. Careful review of the literature reveals that atheroembolization does occur during renal arterial interventions, although it often goes undetected. Early experience with DPDs in the renal arteries in patients with suitable anatomy suggests retrieval of embolic materials in approximately 71% of cases and renal functional improvement/stabilization in 98% of cases. The combination of platelet inhibition and a DPD may provide even greater benefit. Given the critical importance of renal functional preservation, it follows that everything that can be done to prevent atheroembolism should be undertaken including the use of DPDs when anatomically feasible. The data available at this time support a beneficial role for these devices.
authors.affiliation: Department of Diagnostic Imaging, Division of Interventional Radiology, Brown University Medical School, Providence, RI 02903, USA. gdubel@lifespan.org
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Dubel
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Murphy
mesh_terms: D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D002986:Clinical Trials as Topic; D004617:Embolism / Q000517:prevention & control*; D017700:Embolism, Cholesterol / Q000517:prevention & control; D004867:Equipment Design; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D019919:Prosthesis Implantation; D015642:Radiology, Interventional / Q000379:methods*; D012077:Renal Artery / Q000601:surgery; D012078:Renal Artery Obstruction / Q000601:surgery*; D012079:Renal Circulation; D015607:Stents / Q000009:adverse effects