Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population.
The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined using a population of the Takahata Study (n (M/W): 2930 (1328/1602); age: 63.3+/-10.2 years), a Japanese community-based study. Quantitative association study of the SNPs with HbA1c levels showed significant association for SNPs 2 and 4 (p=0.018 and 0.004, respectively). A case-control association study of SNP 4 with diabetes by multiple logistic regression analysis showed a significant association of the genotype TT of the SNP with an odds ratio of 2.21 (p=0.001) independently of age, gender and BMI. In the NGT subjects, serum fasting insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the others (TT, TC, and CC, 4.9+/-2.6, 5.4+/-3.0, and 5.6+/-3.4muU/ml, respectively; p=0.029).
Daimon
Makoto
M
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Sato
Hidenori
H
Oizumi
Toshihide
T
Toriyama
Sayumi
S
Saito
Takafumi
T
Karasawa
Shigeru
S
Jimbu
Yumi
Y
Wada
Kiriko
K
Kameda
Wataru
W
Susa
Shinji
S
Yamaguchi
Hiroshi
H
Emi
Mitsuru
M
Muramatsu
Masaaki
M
Kubota
Isao
I
Kawata
Sumio
S
Kato
Takeo
T
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D019869:Phosphatidylinositol 3-Kinases; C525865:PIK3C2G protein, human