title: Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.
abstract: The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 microM, and relatively high cytotoxicity with a CC50 of 37 microM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 microM, but exhibited a far more less cytotoxicity (CC50 500 microM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.
authors.affiliation: Laboratory of Medicinal Microbiology, Yokohama College of Pharmacy, Kanagawa 245-0066, Japan. t.hosono@hamayaku.ac.jp
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Hosono
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Hamasaki
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okawara
authors.forename: Masami
authors.initials: M
authors.lastname: Otsuka
authors.forename: Ryozaburo
authors.initials: R
authors.lastname: Mukai
authors.forename: Keitarou
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; D006639:Histidine