title: Arterial Spin Labeling: a one-stop-shop for measurement of brain perfusion in the clinical settings.
abstract: Arterial Spin Labeling (ASL) has opened a unique window into the human brain function and perfusion physiology. Altogether fast and of intrinsic high spatial resolution, ASL is a technique very appealing not only for the diagnosis of vascular diseases, but also in basic neuroscience for the follow-up of small perfusion changes occurring during brain activation. However, due to limited signal-to-noise ratio and complex flow kinetics, ASL is one of the more challenging disciplines within magnetic resonance imaging. In this paper, the theoretical background and main implementations of ASL are revisited. In particular, the different uses of ASL, the pitfalls and possibilities are described and illustrated using clinical cases.
authors.affiliation: National Neuroscience Institute, Department of Neuroradiology, Singapore, 138667. xavier_golay@sbic.a-star.edu.sg
authors.forename: Xavier
authors.initials: X
authors.lastname: Golay
authors.forename: Esben T
authors.initials: ET
authors.lastname: Petersen
authors.forename: Ivan
authors.initials: I
authors.lastname: Zimine
authors.forename: Tchoyoson C C
authors.initials: TC
authors.lastname: Lim
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008955:Models, Cardiovascular; D008991:Monitoring, Physiologic; D011859:Radiography; D013113:Spin Labels
chemical_list: D013113:Spin Labels