title: Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation.
abstract: A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor.
authors.affiliation: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
authors.forename: N R
authors.initials: NR
authors.lastname: Thimmegowda
authors.forename: S
authors.initials: S
authors.lastname: Nanjunda Swamy
authors.forename: C S Ananda
authors.initials: CS
authors.lastname: Kumar
authors.forename: Y C Sunil
authors.initials: YC
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Chandrappa
authors.forename: George W
authors.initials: GW
authors.lastname: Yip
authors.forename: K S
authors.initials: KS
authors.lastname: Rangappa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles