title: [Significance of the ratio of circulating endothelial cell expressing endothelial lipase and supersensitivity C-reactive protein in prognosis of patients with coronary artery disease].
abstract: OBJECTIVE
  To evaluate the significance of the ratio of circulating endothelial cell expressing endothelial lipase (EL(+)/CECs) and supersensitivity C-reactive protein (hsCRP) in prognosis of patients with coronary artery disease (CAD).
  
  
  METHODS
  one hundred and seven patients with acute coronary syndrome (ACS), 69 patients with stable angina pain (SAP), and 82 patients in whom CAD was excluded to serve as control were included for study. Blood samples were collected from ulnar vein, and hsCRP was detected, circulating endothelial cells (CECs) were isolated, and the ratio of CEC (EL(+)/CECs) which expressed endothelial lipase (EL) was determined by immunohistochemistry. Over a follow-up period of 6 months, the incidence of cardiac event of all patients was recorded.
  
  
  RESULTS
  In patients with CAD, the EL(+)/CECs and hsCRP were significantly different among groups (P<0.05 or P<0.01). Among them, hsCRP and EL(+)/CECs were higher in ACS group than SAP group patients, whose hsCRP and EL(+)/CECs higher than the control group. The incidence rate of cardiovascular event was significantly higher (all P<0.01) in those whose hsCRP or EL(+)/CECs was higher than those whose with lower average values of these two parameters. Regression analysis indicated that the EL(+)/CECs and hsCRP could be used as the prognostic factor of CAD. The prognostic value of combined determination of EL(+)/CECs and hsCRP was higher.
  
  
  CONCLUSIONS
  The expression of EL in endothelial cells may play a role in the progression of CAD. The EL(+)/CECs may be a good prognostic factor. EL(+)/CECs together with hsCRP may increase the prognostic value.
authors.affiliation: Research Institute of Angiocardiopathy, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
authors.forename: Yu-qiang
authors.initials: YQ
authors.lastname: Fang
authors.forename: Lan
authors.initials: L
authors.lastname: Huang
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Li
authors.forename: Yao-ming
authors.initials: YM
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.forename: Zhao-hua
authors.initials: ZH
authors.lastname: Geng
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Yu
authors.forename: Meng-yang
authors.initials: MY
authors.lastname: Deng
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood*; D042783:Endothelial Cells / Q000201:enzymology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008049:Lipase / Q000097:blood*; D008297:Male; D011379:Prognosis
chemical_list: D002097:C-Reactive Protein; C410382:LIPG protein, human; D008049:Lipase