[The relationship between clinical outcomes of reproduc-tive abnormalities and chromosome polymorphism].
To study the relationship between chromosome polymorphism and clinical effect of reproductive abnormalities, we prepared chromosomes from peripheral blood lymphocytes and carried out G/C banding and karyotype analyses. Out of 1 414 cases who came in for genetic counseling, 273 had chromosome abnormalities. Among these 273 cases, 180 cases (65.93%) were karyotype variations, with the remaining 93 cases (34.07%) being non-polymorphic chromosomal abnormalities. Karyotype variations included 10 cases of satellite increases in the D/G group, 35 cases of secondary constriction increases, 99 cases of big or small Y chromosome, 6 cases of pericentric inversion of chromosome Y and 30 cases of pericentric inversion of chromosome 9. These results indicated that clinical effect such as abortion, sterility, stillbirth and congenital malformation are mainly related to chromosome polymorphisms.
Wang
Xiao-Rong
XR
Medical School of Yongzhou, Professional Technical College, Hunan 425000, China. yzxrw@163.com
Deng
Jian-Xia
JX
Li
Jin-Jin
JJ
D002869:Chromosome Aberrations; D023902:Chromosome Pairing / Q000502:physiology; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D000013:Congenital Abnormalities / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D013223:Statistics as Topic