title: [Association of endothelial nitric oxide synthase gene polymorphism with level of uric acid in serum for acute coronary syndrome].
abstract: OBJECTIVE
  To evaluate the association of elevation in serum uric acid with the development of coronary artery disease, and to determine the relationship between uric acid and Glu(298) Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene in acute coronary syndrome (ACS) in the Chinese Han Nationality.
  
  
  METHODS
  The Glu(298) Asp variant of the eNOS gene was detected by polymerase chain reaction/restriction fragment length polymorphism analysis in 58 patients with ACS and 43 healthy controls. The severity of ACS was expressed by the number of affected vessels and by the Duke scoring system.
  
  
  RESULTS
  The frequencies of the eNOS Glu/Glu, Glu/Asp, and Asp/Asp genotypes in the ACS group were not significantly different from those of controls (43.1%, 36.2%, 20.7% vs. 48.8%, 34.9%, 16.3%, respectively; chi (2) = 0.446, P = 0.800). In comparison with subjects who had Glu(298) allele in the eNOS gene, the risk of ACS was not increased among Asp/Asp carriers (odds ratio 1.34, 95% confidence interval 0.479 to 3.755, P = 0.575). There was no significant association between the eNOS Glu(298) Asp variant and the Duke score [(46.73+/-19.90) score for Asp/Asp vs. (48.33+/-19.61) score and (38.19+/-15.12) score for Glu/Glu and Glu/Asp, respectively, P=0.248], but there was a significant association between the eNOS Glu(298) Asp variant and the serum uric acid level in ACS group [(298.92+/-87.27) micromol/L for Glu/Glu vs.(380.80+/-95.80) micromol/L and (346.16+/-93.71) micromol/L for Glu/Asp and Asp/Asp, respectively, P = 0.017].
  
  
  CONCLUSIONS
  Glu(298) Asp polymorphism of the eNOS gene appears to have no association with ACS in the Chinese Han Nationality, but a significant association between the eNOS Glu(298) Asp variant and the serum uric acid level is found in patients with ACS.
authors.affiliation: Department of Cardiology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Zhi-lu
authors.initials: ZL
authors.lastname: Wang
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Zhao
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Liao
authors.forename: Jin-chun
authors.initials: JC
authors.lastname: He
authors.forename: Rui-jun
authors.initials: RJ
authors.lastname: Dai
authors.forename: Shou-lan
authors.initials: SL
authors.lastname: Shi
authors.forename: Hai-ping
authors.initials: HP
authors.lastname: Peng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000235:genetics; D002681:China; D005006:Ethnicity; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D052250:Nitric Oxide Synthase Type III