[DRESS syndrome, a drug reaction which remains bad known from paediatricians].
The DRESS syndrome (Rash with Eosinophilia and Systemic Symptoms) is a drug hypersensitivity reaction poorly known by paediatricians. It occurs within 1 to 8 weeks of treatment. Clinical features associate in variable patterns, fever, rash, lymphadenopathies, arthritis and potentially life-threatening damage (hepatitis, nephritis, pneumonitis), hyperleucocytosis and eosinophilia. This condition must be early recognized in order to immediately stop suspect drugs. A 6.5 year old girl had a febrile rash, hyperleucocytosis, lymph nodes and cytolitic hepatitis probably due to phenobarbital. Diagnosis of DRESS syndrome was performed only 13 days after the beginning of the eruption. Evolution was favorable but characterized by the recurrence of the febrile eruption with pleuritis. DRESS syndrome is a well described disease that occurs during treatment with a number drugs, particularly anti-epileptic drugs. Steroid therapy and immunoglobulins are proposed for treatment but have not been evaluated.
Autret-Leca
E
E
Service de pharmacologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Bretonneau, CHRU de Tours, Tours cedex 09, France. autret-leca@med.univ-tours.fr
Norbert
K
K
Bensouda-Grimaldi
L
L
Jonville-Béra
A-P
AP
Saliba
E
E
Bentata
J
J
Barthez-Carpentier
M-A
MA
D000927:Anticonvulsants / Q000009:adverse effects; D002648:Child; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D013577:Syndrome
D000927:Anticonvulsants