title: Is serum protein electrophoresis useful in separating the "high risk group" in patients with colonic polyps?
abstract: BACKGROUND
  Adenomas have the highest potential or clinical value from among colonic polyps of developing into adenocarcinoma. The aims of this paper are: to establish criteria to identify the high risk group of patients in a group of patients with colonic polyps, to work out a simple scheme for follow-up care after endoscopic polypectomy, and to establish indications for surgery. The usefulness of determination of electrophoresis of serum proteins has been specially analysed to detect early development of malignant growths in patients with colonic polyps regarding alfa-1/alfa-2 and alfa/beta. 67 cases - 21 women, 46 men were tested. Follow-up endoscopy with the electrophoresis was performed after 6 weeks, 6 and 12 months after polypectomy. 97 polyps were resected with endoscopy in 67 patients. 38 patients (39.17%), those constituting the high risk group, were selected. Included were all polyps with grade II and III of cellular differentiation.
  
  
  CONCLUSIONS
  1) alfa-1/alfa-2 and alfa/beta is a helpful test in identifying the high risk group among patients with colonic polyps and it can be used as a screening test, 2) the determination of beta-2-macroglobuline is not useful in the diagnosis of this group of patients, 3) the electrophoresis of proteins should be the first test to perform on patients with colonic polyps. The relation of electrophoresis to endoscopic polypectomy aids evaluations of patients specially predisposed to malignant.
authors.affiliation: Independent Clinical Immunodiagnostic Laboratory, Department of General and Coloproctological Surgery of Silesian University of Medicine, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Kokocinska
authors.forename: Michal
authors.initials: M
authors.lastname: Grzyb
authors.forename: Michal
authors.initials: M
authors.lastname: Dyaczynski
authors.forename: Robert
authors.initials: R
authors.lastname: Partyka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sikora
authors.forename: Jacek
authors.initials: J
authors.lastname: Starzewski
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Kozera
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000517:prevention & control / Q000601:surgery; D018256:Adenomatous Polyps / Q000145:classification / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001797:Blood Protein Electrophoresis / Q000379:methods*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000517:prevention & control / Q000601:surgery; D003111:Colonic Polyps / Q000145:classification / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008259:Macroglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor; D008259:Macroglobulins