Prevalence, course, and risk factors for antenatal anxiety and depression.
OBJECTIVE
To estimate the prevalence and course of antenatal anxiety and depression across different stages of pregnancy, risk factors at each stage, and the relationship between antenatal anxiety and depression and postpartum depression.


METHODS
A consecutive sample of 357 pregnant women in an antenatal clinic in a regional hospital was assessed longitudinally at four stages of pregnancy: first trimester, second trimester, third trimester, and 6 weeks postpartum. The antenatal questionnaire assessed anxiety and depression (using the Hospital Anxiety and Depression Scale) and demographic and psychosocial risk factors. The postpartum questionnaire assessed postpartum depression with the Edinburgh Postnatal Depression Scale.


RESULTS
More than one half (54%) and more than one third (37.1%) of the women had antenatal anxiety and depressive symptoms, respectively, in at least one antenatal assessment. Anxiety was more prevalent than depression at all stages. A mixed-effects model showed that both conditions had a nonlinear changing course (P<.05 for both), with both being more prevalent and severe in the first and third trimesters. Risk factors were slightly different at different stages. Both antenatal anxiety (adjusted odds ratio [OR] 2.66, P=.004 in the first trimester; adjusted OR 3.65, P<.001 in the second trimester; adjusted OR 3.84, P<.001 in the third trimester) and depression (adjusted OR 4.16, P<.001 in the first trimester; adjusted OR 3.35, P=.001 in the second trimester; adjusted OR 2.67, P=.009 in the third trimester) increased the risk of postpartum depression.


CONCLUSIONS
Antenatal anxiety and depression are prevalent and serious problems with changing courses. Continuous assessment over the course of pregnancy is warranted. Identifying and treating these problems is important in preventing postpartum depression.


METHODS
II.
Lee
Antoinette M
AM
Department of Psychiatry, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong. amlee@hkucc.hku.hk
Lam
Siu Keung
SK
Sze Mun Lau
Stephanie Marie
SM
Chong
Catherine Shiu Yin
CS
Chui
Hang Wai
HW
Fong
Daniel Yee Tak
DY
D000328:Adult; D001007:Anxiety / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology*; D019052:Depression, Postpartum / Q000209:etiology; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000523:psychology*; D011264:Pregnancy Trimesters; D011296:Prenatal Diagnosis / Q000523:psychology*; D015995:Prevalence; D012307:Risk Factors