Histopathologic and trypsin digestion studies of the retina in incontinentia pigmenti.
OBJECTIVE
To report the ocular histopathologic features of a 55-year-old patient with incontinentia pigmenti retinopathy.


METHODS
Observational case report.


METHODS
A 55-year-old patient with incontinentia pigmenti retinopathy.


METHODS
Examination of eyes by light microscopy and retinal trypsin digestion.


METHODS
Clinical and histopathological findings.


RESULTS
Histopathologic examination disclosed inner retinal ischemic atrophy, capillary beading, arteriolar-venous anastomoses, preretinal neovascularization, vasculopathy located at the junction of central vascular and peripheral avascular retina, retinal tears, and tractional retinoschisis.


CONCLUSIONS
Patients with retinal manifestations of incontinentia pigmenti may progress to proliferative vitreoretinopathy or retinal detachment and should be observed closely over the course of their lifetime.
Bell
W Robert
WR
Eye Pathology Laboratory, Department of Pathology, Wilmer Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Green
W Richard
WR
Goldberg
Morton F
MF
D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007184:Incontinentia Pigmenti / Q000175:diagnosis*; D008875:Middle Aged; D012160:Retina / Q000187:drug effects; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*; D014357:Trypsin / Q000494:pharmacology*
D014357:Trypsin