[Ethnic background related pharmacological differences].
The cytochrome P-450 enzyme plays a key role in the metabolization of many medicinal products. Certain ethnic groups particularly often show gene polymorphisms that lead to more rapid or slower metabolization of the active substance depending on how the enzyme activity is affected. This should be taken into consideration when prescribing the dosage of medicines to avoid increased side effects or therapeutic failure.
Reinbold
H
H
LWL-Klinik, Dortmund. h.reinbold@wkp-lwl.org
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D011307:Drug Prescriptions; D004358:Drug Therapy; D054242:Emigrants and Immigrants; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D011110:Polymorphism, Genetic; D012737:Sex Factors
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System