U2 snRNP: not just for poly(A) mRNAs.
Polyadenylated mRNAs and replication-dependent histone mRNAs, which are not polyadenylated, share factors involved in 3' end formation. Friend et al. (2007) now report that the U2 snRNP, required for pre-mRNA splicing, is also required for histone mRNA 3' end formation.
Marzluff
William F
WF
Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA. william_marzluff@med.unc.edu
D006657:Histones / Q000235:genetics / Q000378:metabolism; D026721:RNA 3' End Processing; D012322:RNA Precursors / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism; D017413:Ribonucleoprotein, U2 Small Nuclear / Q000737:chemistry / Q000378:metabolism*; D020885:Ribonucleoprotein, U7 Small Nuclear / Q000737:chemistry / Q000378:metabolism
D006657:Histones; D012322:RNA Precursors; D012333:RNA, Messenger; D017413:Ribonucleoprotein, U2 Small Nuclear; D020885:Ribonucleoprotein, U7 Small Nuclear