[Pulse pressure, arterial compliance and Buckberg index in hypertensive patients treated with nebivolol and nitrates].
OBJECTIVE
To evaluate the effect of nebivolol and nitrate administration on the arterial compliance--an essential factor for left ventricular hypertrophy regression.


METHODS
The arterial compliance was assessed in 32 hypertensive patients (mean age 52.3 years +/- 11, M/F ratio = 26/6) before drug administration, three hour post oral intake of nebivolol 5 mg and five minutes after sublingual 0.5 mg nitroglycerin.


METHODS
mean aortic blood pressure (PAom), pulse pressure (PP), augmentation index (AGIx) and Buckberg index (diastolic pressure-time index/systolic pressure-time index). The statistical significance of the results was determined by means of t-Student test.


RESULTS
After nebivolol: PAom decreased from 131.2 +/- 15 mmHg to 118 +/- 15.3 mmHg; PP decreased from 72.5 +/- 12 mmHg to 52.3 +/- 11.3 mmHg; AG decreased from 17 to 10.2 mmHg, AGIx decreased from 26.4% to 22.3%, Buckberg index increased from 145.4 +/- 25% to 161.4 +/- 30%. After nitroglycerin: PAom decreased to 108.5 +/- 12 mmHg; PP decreased to 41.2 +/- 9.3 mmHg; AG decreased to 2.3 mmHg, AGIx decreased to 3.6%, Buckberg index increased to 171.2 +/- 32%.


CONCLUSIONS
Nebivolol and nitrates determined a significant lowering of mean aortic pressure and an increase of the arterial compliance suggesting a beneficial effect that could promote the regression of left ventricular hypertrophy.
Prisadă
O V
OV
Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi, Facultatea de Medicină, Clinica Medicala IV, Spitalul Clinic Nr. 2 "C.I. Parhon" Iaşi.
Covic
A
A
Arghiri
Elena
E
Cernomaz
A
A
Ungureanu
G
G
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000187:drug effects*; D001578:Benzopyrans / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D003187:Compliance / Q000187:drug effects; D003971:Diastole; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D005996:Nitroglycerin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013599:Systole; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D014665:Vasodilator Agents; D000068577:Nebivolol; D005996:Nitroglycerin