title: [Pancreaticoduodenectomy for pancreatic head cancer, 54 cases].
abstract: Pancreatic cancer has an increase rate in western countries. From the first pancreaticoduodenectomy (PD) performed by Kausch in 1909, the value of the resection in the treatment of pancreatic head cancer was disputed.
  
  
  OBJECTIVE
  To assess the PD with or without pylorus preservation as surgical treatment for pancreatic cancer.
  
  
  METHODS
  Retrospective review of the clinical records of patients undergoing PD for pancreatic cancer.
  
  
  RESULTS
  From January 1995 till December 2005, in the First and Third Surgical Units, "St. Spiridon" University Hospital Iaşi, Romania, were performed 137 PD. From these, 54 cases were histologic diagnosed with pancreatic cancer; 23 cases underwent pylorus preserving pancreatico-duodenectomy (PPPD) and 31 patients, classical Whipple procedure (PDW). Mean age was 59.07 +/- 1.42 years old (26-75 years old), and male to female ratio was 29 to 25. Jaundice was presented in 51 cases (94.4%), abdominal pain at 39 patients (72.2%) and Curvoisier-Terrier sign at 37 cases (68.7%). Fever was observe only in 4 cases (7.4%). Other biological and imaging parameters (e.g. main diameter of the biliary duct, tumor and wirsung ) were also discussed, but no significant difference was found between PPPD and PDW. Pancreatico-jejunostomy was performed in 41 cases (28 during the PDW and 13 in PPPD) and 13 pancreatico-gastrostomy (3 during PDW and 10 during PPPD). Mean operating time and mean blood loss in the PDW group were 358.22 +/- 10.53 minutes and 587.74 +/- 60.87 mL. After PPPD, these figures were 326.08 +/- 15.04 minutes and 571.74 +/- 90.50 mL, but no significant difference was noted. Delayed Gastric Emptying (DGE) was presented at 15 patients: 8 in PPPD group and 7 in PDW group (p=0.322). Postoperative morbidity rate (excluding DGE) was 33.33% (8 cases in PDW group and 10 in PPPD group). Pancreatic leak has a rate of 5.55% (3 cases--one in PPPD group vs two in PDW group), biliary leak has a rate of 12.96% (4 in PPPD group vs 3 in PDW group)and duodeno-jejunal anastomotic fistula appeared in one cases (PPPD). Acute postoperative pancreatitis is presented in one case (PPPD group) and postoperative hemorrhage appeared in 4 cases (2 in PPPD and 2 after PDW). Hospital stay was 19.91 +/- 2.28 days in PPPD group vs 18.87 +/- 2.24 days in PDW group (p = 0.751). Postoperative mortality rate was 5.5% (one case after PPD and 3 cases after PDW). Histological exam diagnosed ductal pancreatic adenocarcinoma in 51 cases (94.44%). Mean long-term survival rate was 20.98 months (10.52-31.45 months; 95 CI) and no difference was revealed between PPPD and PDW (log rank test - p = 0.796).
  
  
  CONCLUSIONS
  PD should be performed for any pancreatic tumor even without preoperative histologic confirmation. The results after PPPD (postoperative morbidity and mortality, long-term survival) are similar to that following conventional Whipple procedure, if the principles of viable and tumor free margins are observed.
authors.affiliation: Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi. Facultatea de Medicină Clinica I Chirurgie "I. Tănăsescu-Vl. Buţureanu" Iaşi.
authors.forename: R
authors.initials: R
authors.lastname: Moldovanu
authors.forename: F
authors.initials: F
authors.lastname: Grecu
authors.forename: E
authors.initials: E
authors.lastname: Târcoveanu
authors.forename: St
authors.initials: S
authors.lastname: Georgescu
authors.forename: V
authors.initials: V
authors.lastname: Scripcariu
authors.forename: D
authors.initials: D
authors.lastname: Niculescu
authors.forename: C
authors.initials: C
authors.lastname: Burcoveanu
authors.forename: N
authors.initials: N
authors.lastname: Dănilă
authors.forename: Lidia
authors.initials: L
authors.lastname: Andriescu
authors.forename: C
authors.initials: C
authors.lastname: Bradea
authors.forename: C
authors.initials: C
authors.lastname: Bulat
authors.forename: M
authors.initials: M
authors.lastname: Chifan
authors.forename: Cristina
authors.initials: C
authors.lastname: Dăscălescu
authors.forename: A
authors.initials: A
authors.lastname: Grigorovici
authors.forename: D
authors.initials: D
authors.lastname: Lăzescu
authors.forename: S
authors.initials: S
authors.lastname: Pădureanu
authors.forename: M
authors.initials: M
authors.lastname: Stoian
authors.forename: D
authors.initials: D
authors.lastname: Ferariu
authors.forename: Felicia
authors.initials: F
authors.lastname: Crumpei
authors.forename: C
authors.initials: C
authors.lastname: Pleşa
authors.forename: Cr
authors.initials: C
authors.lastname: Dragomir
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania; D016019:Survival Analysis; D016896:Treatment Outcome