title: A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence.
abstract: Porcine circovirus type 2 (PCV2) is the essential infectious agent of postweaning multisystemic wasting syndrome (PMWS). Despite first sequencing studies did not find any association between PCV2 sequences and PMWS occurrence, recent works have suggested the opposite. In the present study, 87 open reading frame 2 (ORF2) sequences obtained from pigs with different clinical conditions and coming from farms with different PMWS status were analyzed. Results further confirmed the existence of two genogroups and the definition of two PCV2 genotypes (1 and 2) is proposed. All sequences included in genotype 1 came from pigs from PMWS affected farms, while all sequences obtained from non-PMWS affected farms corresponded to genotype 2. Moreover, infection of single pigs from PMWS affected farms harbouring both genotypes is described. Present results suggest that PCV2 genotype 1 may potentially be more pathogenic than PCV2 genotype 2.
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), Esfera Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. llgrau@cresa.uab.cat
authors.forename: L
authors.initials: L
authors.lastname: Grau-Roma
authors.forename: E
authors.initials: E
authors.lastname: Crisci
authors.forename: M
authors.initials: M
authors.lastname: Sibila
authors.forename: S
authors.initials: S
authors.lastname: López-Soria
authors.forename: M
authors.initials: M
authors.lastname: Nofrarias
authors.forename: M
authors.initials: M
authors.lastname: Cortey
authors.forename: L
authors.initials: L
authors.lastname: Fraile
authors.forename: A
authors.initials: A
authors.lastname: Olvera
authors.forename: J
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000595:Amino Acid Sequence; D000822:Animal Husbandry; D000818:Animals; D001483:Base Sequence; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D004279:DNA, Viral / Q000235:genetics; D005838:Genotype; D008969:Molecular Sequence Data; D010802:Phylogeny; D053570:Porcine Postweaning Multisystemic Wasting Syndrome / Q000821:virology*; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
chemical_list: D004279:DNA, Viral