title: [The influence of protein and phosphorous restricted diet supplemented with essential aminoacids (EAA) and their alpha-keto-analogues (KAA) on nutritional status of children with chronic renal failure (CRF)].
abstract: The purpose of the study was to establish the influence of protein restricted diet supplemented with EAA/KAA on nutritional status of children with CRF. Seven childredn (four girls and three boys), aged from 7 years and eight months to 14 years and two months, with glomerular filtration rate of 42.6-9.2 ml/min/1.73 m2 and proteinuria of 0.025-1.125 g/24 h, who were on conservative treatment and who lived at home, were observed for six months. In prescribing energy value and protein intake WHO recommendations were used for healthly children (age for height). Through food 80-90% of energy and 80-85% of protein needs were provided. The remaining energy and proteins were provided by glucodextrin and EAA/KAA supplements respectevely. Average daily phosphorous intake amounted to about 550-800 mg. The obtained results showed that stunting and kwashiorkor like aminoacid disbalance were the prominent nutritional problems. This dietary regimen had a beneficial effect on all studied parameters. especially on height standard deviation score which increased from 1.71 +/- 2.6 to 1.5 +/- 4.3 (t = 2.809, p < 0.05); total essential/nonessential aminoacid score increased from 0.38 +/- 0.2 to 0.56 +/- 0.2 (t = 2.763, p < 0.05). The ratio between plasma concentration of four nonessential (glycine+serinet glutamine+taurine) to four essential (leucine+isoleucine+valine+methionine) amino acids decreased from 3.82 +/- 1.2 to 2.7 +/- 0.4 (t = 2.528, p < 0.05). Lymphocyte count increased from 1.809 x 10(9) +/- 0.268 x 10(9)/l to 2.314 x 10(9) +/- 0.922 x 10(9)/l (t = 2.431, p < 0.05). No significant changes were found in the values of relative body weight, arm circumpherence, triceps skinfold thickness, total plasma protein, albumin, transferine, complement C3 and plasma valin/glycin and phenylalanine/thyrosine ratio. It should be noted that the significant changes were not found in the results of these latter anthropometric biochemical parameters in relation to their primary almost insignificant values.
authors.forename: Lj
authors.initials: Lj
authors.lastname: Trajković-Pavlović
authors.forename: M
authors.initials: M
authors.lastname: Popović-Rolović
authors.forename: D
authors.initials: D
authors.lastname: Dimitrijević
authors.forename: O
authors.initials: O
authors.lastname: Jovanović
authors.forename: A
authors.initials: A
authors.lastname: Antić-Peco
authors.forename: M
authors.initials: M
authors.lastname: Cvorkov-Drazić
authors.forename: J
authors.initials: J
authors.lastname: Radić
authors.forename: D
authors.initials: D
authors.lastname: Kruscić
authors.forename: M
authors.initials: M
authors.lastname: Kostić
mesh_terms: D000293:Adolescent; D000601:Amino Acids, Essential / Q000008:administration & dosage*; D000886:Anthropometry; D002648:Child; D018753:Diet, Protein-Restricted; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000378:metabolism; D008297:Male; D009752:Nutritional Status; D010758:Phosphorus / Q000008:administration & dosage
chemical_list: D000601:Amino Acids, Essential; D010758:Phosphorus