Synthesis and antiviral bioactivities of alpha-aminophosphonates containing alkoxyethyl moieties.
A simple, efficient, and general method has been developed for the synthesis of various alpha-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new alpha-aminophosphonate derivatives were found to possess moderate to good antiviral activity.
Xu
Yingshu
Y
Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, PR China. xuyingshu1976@126.com
Yan
Kai
K
Song
Baoan
B
Xu
Gangfang
G
Yang
Song
S
Xue
Wei
W
Hu
Deyu
D
Lu
Ping
P
Ouyang
Guiping
G
Jin
Linhong
L
Chen
Zhuo
Z
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005670:Fusarium / Q000187:drug effects; D008872:Microwaves; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000935:Antifungal Agents; D000998:Antiviral Agents; D063065:Organophosphonates