Multicomponent reactions in solid-phase synthesis.
Multicomponent reactions are a powerful tool in combinatorial chemistry and diversity-oriented synthesis for the assembly of collections of complex molecules in a highly straightforward and efficient manner. Additional advantages in terms of isolation and purification can be obtained by performing these condensations on a polymeric support or with the aid of solid-supported reagents, scavengers or catalysts. This review covers research published in this area during the last two years and provides a perspective of future directions.
Banfi
Luca
L
Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, Genoa, Italy.
Guanti
Giuseppe
G
Riva
Renata
R
Basso
Andrea
A
D002617:Chemical Industry / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D004345:Drug Industry / Q000379:methods*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry
D009930:Organic Chemicals; D004364:Pharmaceutical Preparations