title: A new non-invasive method for measuring blood glucose using instantaneous differential near infrared spectrophotometry.
abstract: We describe further development of a novel method for non-invasive measurement of blood glucose concentration (BGL), named Pulse Glucometry, based on differential near infrared spectrophotometry. Sequential temporal differences of infrared transmittance spectra from the radiation intensity (I(lambda)) emerging from a fingertip containing an arterial pulse component (DeltaI(lambda)) are analysed. To perform the measurements we developed a new high-speed spectrophotometer, covering the wavelength range from 900 to 1700 nm, scanning at a maximum spectral rate of 1800 spectra/s, with a minimum exposure time of 20 micros. Spectra related only to the pulsatile blood component are derived, thus minimising influences of basal components such as resting blood volume, skin, muscle and bone. We have now improved the performance of the spectrophotometer and in the present paper we describe new in vivo measurements carried out in 23 healthy volunteers undergoing glucose tolerance tests. Blood samples were collected from the cephalic vein simultaneously with radiation intensity measurements in the fingertip every 10 min before and after oral administration of glucose solution for 120 min. BGL values were then predicted using a PLS calibration model and compared with blood values determined by colorimetric assay. The precision and accuracy of the non-invasive determinations are encouraging.
authors.affiliation: TYT Institute of Technology Corp. 602 Famille Montagnus, 1-143 Morino-Sato, Kanazawa, 920-1167, Japan. yamakoshi@s4.dion.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yamakoshi
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Yamakoshi
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Nogawa
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: P
authors.initials: P
authors.lastname: Rolfe
authors.forename: K
authors.initials: K
authors.lastname: Yamakoshi
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation* / Q000379:methods; D001786:Blood Glucose / Q000032:analysis*; D005240:Feasibility Studies; D005336:Fiber Optic Technology / Q000295:instrumentation*; D006801:Humans; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000379:methods
chemical_list: D001786:Blood Glucose