An in computo investigation of the Landau-Kleffner syndrome.
We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
Bonjean
Maxime
M
Cyclotron Medical Research Center, School of Medicine, University of Liege, 4000 Liege, Belgium. m.bonjean@ulg.ac.be
Phillips
Christophe
C
Vu
Thien Thanh Dang
TT
Sepulchre
Rodolphe
R
Maquet
Pierre
P
D002540:Cerebral Cortex / Q000503:physiopathology; D003198:Computer Simulation; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology