title: [Effect of pyruvate and valine on avermectin biosynthesis by Streptomyces avermitilis UCM Ac-2179].
abstract: Pyruvate and valine have been studied for their effect on avermectin biosynthesis by the mutant strain Streptomyces avermitilis UCM Ac-2179. Valine in concentrations 0.5, 1.0 and 1.5 g/l inhibited the antibiotic synthesis. The same concentrations of pyruvate increased the avermectin production 2-2.5 times. The strain cultivated in the mineral medium produced during trophophase some lipids which were not almost revealed during idiophase when avermectin active synthesis took place. The authors make a supposition about the ways of avermectin synthesis by S. avermitilis UCM Ac-2179: the antibiotic biosynthesis can proceed not only through pyruvate transformation but, to a considerable extent, at the expense of using fatty acids which are produced by the culture.
authors.forename: L O
authors.initials: LO
authors.lastname: Biliavs'ka
authors.forename: V Ie
authors.initials: VIe
authors.lastname: Kozyryts'ka
authors.forename: O V
authors.initials: OV
authors.lastname: Valahurova
authors.forename: H O
authors.initials: HO
authors.lastname: Iutyns'ka
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D018533:Biomass; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000378:metabolism; D005285:Fermentation; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism; D019289:Pyruvic Acid / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014633:Valine / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D007559:Ivermectin; C019264:avermectin; D019289:Pyruvic Acid; D014633:Valine