title: Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.
abstract: It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)(18)E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
authors.affiliation: Laboratory of Cellular Biochemistry, Saitama, Japan, tsujimot@riken.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Goto
authors.forename: Masato
authors.initials: M
authors.lastname: Maruyama
authors.forename: Akira
authors.initials: A
authors.lastname: Hattori
mesh_terms: D000626:Aminopeptidases / Q000737:chemistry / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D018826:CD13 Antigens / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D010122:Cystinyl Aminopeptidase / Q000737:chemistry / Q000378:metabolism; D043384:Glutamyl Aminopeptidase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000503:physiopathology; D008954:Models, Biological
chemical_list: D000626:Aminopeptidases; D018826:CD13 Antigens; D010122:Cystinyl Aminopeptidase; C105964:leucyl-cystinyl aminopeptidase; D043384:Glutamyl Aminopeptidase