title: Imaging the neurochemistry of alcohol and substance abuse.
abstract: Animal models of abuse and dependence have long suggested that chronic drug and alcohol exposure is associated with marked changes in neurochemistry. The development of PET and SPECT imaging now allows investigation of the effects of addiction on the neurochemistry of the human brain. This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box #31, New York, NY 10032, USA. dm437@columbia.edu
authors.forename: Diana
authors.initials: D
authors.lastname: Martinez
authors.forename: Jong-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: John
authors.initials: J
authors.lastname: Krystal
authors.forename: Anissa
authors.initials: A
authors.lastname: Abi-Dargham
mesh_terms: D000437:Alcoholism / Q000000981:diagnostic imaging*; D006801:Humans; D049268:Positron-Emission Tomography; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon