title: Study of an ovarian sclerosing stromal tumor presenting as vaginal bleeding in a 7-month-old.
abstract: This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia-like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.
authors.affiliation: Department of Pathology and Laboratory Medicine, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134, USA.
authors.forename: Odette R
authors.initials: OR
authors.lastname: Hall
authors.forename: Judy M
authors.initials: JM
authors.lastname: Pascasio
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Morrissette
authors.forename: Christopher
authors.initials: C
authors.lastname: Newton
authors.forename: Marshall Z
authors.initials: MZ
authors.lastname: Schwartz
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: de Chadarévian
mesh_terms: D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis*; D010052:Ovariectomy; D018312:Sex Cord-Gonadal Stromal Tumors / Q000737:chemistry / Q000150:complications / Q000175:diagnosis*; D017154:Stromal Cells / Q000473:pathology*; D044767:Ubiquitin-Protein Ligases / Q000032:analysis; D014592:Uterine Hemorrhage / Q000175:diagnosis* / Q000209:etiology
chemical_list: C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases