Mechanical forces and human saphenous veins: coronary artery bypass graft implications.
Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynamic, functional and morphological human saphenous veins alterations caused by these different forces with conflictant results. This review text was motivated with the specific aim of analyze literature data and some experimental data carried out in our laboratory. The adopted review subjects were: 1) Endothelial responses and gene regulation to shear stress; 2) Effects of the hydrostatic pressure in the endothelial cell morphology, gene expression of the endothelial cellular surface and proliferation of endothelial cells; 3) Effects of the traction on the human saphenous vein endothelium.
Tineli
Rafael Angelo
RA
Surgery and Anatomy Department of the Medical School in Ribeirão Preto of the University of São Paulo.
Viaro
Fernanda
F
Dalio
Marcelo Bellini
MB
Reis
Graziela Saraiva
GS
Basseto
Solange
S
Vicente
Walter Villela de Andrade
WV
Rodrigues
Alfredo José
AJ
Evora
Paulo Roberto Barbosa
PR
D000818:Animals; D001026:Coronary Artery Bypass; D042783:Endothelial Cells / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D006874:Hydrostatic Pressure; D012501:Saphenous Vein / Q000502:physiology* / Q000637:transplantation; D033081:Shear Strength; D013314:Stress, Mechanical; D020858:Tissue and Organ Harvesting / Q000379:methods; D014654:Vascular Patency