title: One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study.
abstract: This study was conducted to evaluate the chronic toxicity of Aloe arborescens Miller var. natalensis Berger (ALOE) in the diet at doses of 4.0%, 0.8% or 0.16% to groups of male and female Wistar Hannover rats. No deaths occurred at any dose level throughout the treatment period. Both sexes receiving 4.0% showed diarrhea, with a reduced body weight gain. Increase of WBCs in the male 4.0% group, decrease of Hb in the female 4.0% and 0.8% groups, decrease of IP in the male 4.0% and 0.8% groups and female 4.0% group, and decrease of Ca and ALT in the female 4.0% group were observed. Relative kidney weight showed increase in the female 4.0% group and relative heart and brain weights were decreased in the female 4.0% and 0.8% groups. Histopathologically, both sexes receiving 4.0% showed severe sinus dilatation of ileocecal lymph nodes, and yellowish pigmentation of ileocecal lymph nodes and renal tubules. In conclusion, the no observed adverse effect level (NOAEL) for ALOE was the 0.16% in diet, which is equivalent to 87.7 and 109.7 mg/kg/day in males and females, respectively.
authors.affiliation: Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Masanao
authors.initials: M
authors.lastname: Yokohira
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ninomiya
authors.forename: Kousuke
authors.initials: K
authors.lastname: Saoo
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kuno
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaida
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D007684:Kidney Tubules / Q000187:drug effects* / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008297:Male; D037241:Mannose-Binding Lectins / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010865:Pilot Projects; D018515:Plant Leaves; D037121:Plant Lectins / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats
chemical_list: D037241:Mannose-Binding Lectins; D037121:Plant Lectins; C095581:mannose-binding lectin, Kidachi Aloe