title: Normalization of diastolic dysfunction in type 2 diabetics after exercise training.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the impact of aerobic exercise training on left ventricular diastolic dysfunction (LVDD) and exercise capacity in subjects with type 2 diabetes.
  
  
  METHODS
  Twenty-three sedentary subjects with well-controlled type 2 diabetes, free of coronary disease and having different degrees of LVDD, participated in the study. Subjects were treated with oral hypoglycemic agents and/or diet. Eleven subjects (EX) (age: 58 +/- 5 yr; mean +/- SD) underwent a 3-month aerobic exercise training program using a cycle ergometer, whereas a control group (CONT) of 12 subjects (57 +/- 6 yr) maintained their activities of daily living. Exercise capacity and LVDD, using echocardiography, were evaluated before and after the 3-month exercise program.
  
  
  RESULTS
  At baseline, anthropometric data were similar between the groups, except for body mass index (BMI), which was higher in CONT (31 +/- 3 vs 28+/- 3 kg x m(-2); P < 0.05). There were no significant differences in glycemic control (HbA1c: 6.4 +/- 1.2 vs 5.8 +/- 1.3%; P = 0.2) or maximal oxygen uptake (26.7 +/- 5.9 vs 28.6 +/- 3.9 mL x kg(-1) x min(-1); P = 0.4) between groups. Normalization of LVDD was observed in 5 of 11 EX subjects, (P < 0.0001) of whom four had grade 1 LVDD before exercise training. No change in diastolic function was observed in the CONT group. After exercise training, maximal oxygen uptake increased in the EX group (28.6 +/- 3.9 vs 32.7 +/- 5.7 mL x kg(-1) x min(-1); P < 0.05), whereas there was no change in the CONT group (26.7 +/- 5.9 vs 27.3 +/- 6.2 mL x kg(-1) x min(-1); P = 0.58). In both groups, there was no significant change in BMI.
  
  
  CONCLUSIONS
  Along with an improvement in exercise capacity, aerobic exercise training has the potential to reverse LVDD in patients with well-controlled, uncomplicated type 2 diabetes.
authors.affiliation: Laval Hospital Research Center, Quebec Heart and Lung Institute, Quebec, Canada.
authors.forename: Patrice
authors.initials: P
authors.lastname: Brassard
authors.forename: Sylvie
authors.initials: S
authors.lastname: Legault
authors.forename: Caroline
authors.initials: C
authors.lastname: Garneau
authors.forename: Peter
authors.initials: P
authors.lastname: Bogaty
authors.forename: Jean-Gaston
authors.initials: JG
authors.lastname: Dumesnil
authors.forename: Paul
authors.initials: P
authors.lastname: Poirier
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D003971:Diastole; D004452:Echocardiography; D015444:Exercise; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008875:Middle Aged; D011792:Quebec
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents