Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats.
It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue. The present study evaluated this hypothesis by observing the behavior of systematized septal fibrosis induced by either 30 or 90-day-old Capillaria hepatica infection, in rats subjected to partial hepatectomy. The results revealed that the morphology of the fibrosis was unaffected, but its relative quantity within the microscope field appeared significantly decreased, as a consequence of the increased liver tissue mass following regeneration.
Santos
Carolina Cincurá Silva
CC
Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Valdemar Falcão 121, Salvador, BA, Brazil.
Onofre-Nunes
Záira
Z
Andrade
Zilton Araujo
ZA
D000818:Animals; D002195:Capillaria; D017189:Enoplida Infections / Q000150:complications* / Q000473:pathology; D005260:Female; D006498:Hepatectomy; D008106:Liver Cirrhosis, Experimental / Q000469:parasitology / Q000473:pathology / Q000601:surgery*; D008109:Liver Diseases, Parasitic / Q000469:parasitology / Q000473:pathology / Q000601:surgery*; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D013997:Time Factors