title: A brain implantable microsystem with hybrid RF/IR telemetry for advanced neuroengineering applications.
abstract: A prototype cortical neural interface microsystem has been developed for brain implantable neuroengineering applications, featuring hybrid RF (radio-frequency) inductive and IR (infrared) optical telemetries. The system is aimed at neural recording from primates by converting cortical signals to a digital stream of IR light pulses, while acquiring clock signal and electrical power through RF induction. The implantable unit employs a flexible LCP (liquid crystal polymer) substrate for integration of analog, digital, and optoelectronic components, while adapting to the anatomical and physiological constraints of the environment. An ultra-low power analog CMOS chip, which includes preamplifier and multiplexing circuitry, is directly flip-chip bonded to the microelectrode array to form the immediate cortical neuroprobe device. A 16-channel version of the probe has been tested in various in-vivo animal experiments, including measurements of neural activity in somatosensory cortex of a rat.
authors.affiliation: Division of Engineering, Brown University, Providence, RI 02912, USA. yoon-kyu_song@brown.edu
authors.forename: Yoon-Kyu
authors.initials: YK
authors.lastname: Song
authors.forename: William R
authors.initials: WR
authors.lastname: Patterson
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Bull
authors.forename: David A
authors.initials: DA
authors.lastname: Borton
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Li
authors.forename: Arto V
authors.initials: AV
authors.lastname: Nurmikko
authors.forename: John D
authors.initials: JD
authors.lastname: Simeral
authors.forename: John P
authors.initials: JP
authors.lastname: Donoghue
mesh_terms: D000818:Animals; D002540:Cerebral Cortex; D006801:Humans; D007259:Infrared Rays; D050866:Liquid Crystals; D011108:Polymers; D019736:Prostheses and Implants; D011846:Radio Waves; D051381:Rats; D015398:Signal Transduction; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods
chemical_list: D011108:Polymers; C422409:liquid crystal polymer