Leading to long-term nonprogressor via gradual reduction of drug dose with immune dynamics strongly dependant on target cells.
For a HIV dynamic model with immune system which strongly depends on the HIV target cells, we apply a recently proposed drug scheduling scheme: gradual reduction of drug dose. The feasibility of this scheme is analysed rigorously. By means of this method, the HIV patient is steered to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected status not developing the symptoms of AIDS.
Chang
H
H
Department of Electrical and Electronic Engineering, Imperial College, London SW7 2AZ, UK. hj.chang@ic.ac.uk
Astolfi
A
A
D019380:Anti-HIV Agents / Q000008:administration & dosage*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems / Q000379:methods*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D018448:Models, Immunological
D019380:Anti-HIV Agents