LHRH-(1-5): a bioactive peptide regulating reproduction.
Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.
Roberts
James L
JL
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. robertsjl0@uthscsa.edu
Mani
Shaila K
SK
Woller
Michael J
MJ
Glucksman
Marc J
MJ
Wu
T John
TJ
D000818:Animals; D001921:Brain / Q000502:physiology; D025461:Feedback, Physiological; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000032:analysis / Q000378:metabolism; D010446:Peptide Fragments / Q000096:biosynthesis / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D012098:Reproduction / Q000502:physiology*
C495201:LHRH (1-5); D010446:Peptide Fragments; D007987:Gonadotropin-Releasing Hormone; C037700:LHRH, Gln(8)-; D008666:Metalloendopeptidases; C022510:thimet oligopeptidase; D011761:Pyrrolidonecarboxylic Acid