[Genetic variant C677T in the MTHFR in women with recurrent early fetal loss].
The aim of this study was to evaluate correlation of carrier status for thrombophilic gene mutation--C677T in the methylenetetrahydrofolate reductase (MTHFR) and recurrent early pregnancy loss. Recently inherited thrombophilia was discussed as a predisposed factor for early recurrent fetal loss (ERFL). We investigated carrier status for C677T genetic variant in 54 women with ERFL before 10 week of gestation and 67 women with one or more successful pregnancy. It was found significant prevalence of C677T genetic variant in MTHFR in women with ERFL compared with controls (p = 0.005). The significant high prevalence of C677T genetic variant in women with ERFL suggests that thrombophilia have an increased risk of early pregnancy loss and possibly, although the definition of the magnitude of risk will require prospective longitudinal studies.
Ivanov
P
P
Kovacheva
K
K
Komsa-Penkova
R
R
Konova
E
E
Simeonova
M
M
Popov
I
I
Gecheva
S
S
Bozhinova
S
S
Tanchev
S
S
Tsafarov
M
M
D000026:Abortion, Habitual / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D005865:Gestational Age; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000201:enzymology / Q000235:genetics*; D019851:Thrombophilia / Q000201:enzymology / Q000235:genetics*
D004247:DNA; D042965:Methylenetetrahydrofolate Reductase (NADPH2)