Repair in the central nervous system.
The subject of central nervous system damage includes a wide variety of problems, from the slow selective 'picking off' of characteristic sub-populations of neurons typical of neurodegenerative diseases, to the wholesale destruction of areas of brain and spinal cord seen in traumatic injury and stroke. Experimental repair strategies are diverse and the type of pathology dictates which approach will be appropriate. Damage may be to grey matter (loss of neurons), white matter (cutting of axons, leaving neurons otherwise intact, at least initially) or both. This review will consider four possible forms of treatment for repair of the human central nervous system.
Fitzgerald
J
J
Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, UK. jjf30@cam.ac.uk
Fawcett
J
J
D001369:Axons; D002490:Central Nervous System / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D019957:Motor Skills Disorders / Q000628:therapy; D009416:Nerve Regeneration / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000473:pathology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons; D033581:Stem Cell Transplantation / Q000379:methods