title: Cytogenetic analysis of Down syndrome in Gujarat.
abstract: During 1995 to 2006, 382 cases clinically suspected for Down syndrome were investigated for cytogenetic study. Free trisomy 21 constituted 84.8% of cases, translocation 8.9%, mosaic 3.9% and in 2.4% cases regular T21 was associated with structural or numerical changes. Translocation was parentally inherited in 26.5% cases and maternal transmission was twice as common as paternal. Males were more pronounced to be affected than females in all the groups. 91.6% of DS babies were born to younger mothers (20-35 yr) compared to 8.4% in elderly mothers (>35 yr).
authors.affiliation: FRIGE House (Foundation for Research in Genetics and Endocrinology), Genetic Center, 15 Kapidwaj, Jodhpur Gam Road, Satellite, Ahmedabad 380 015, India. frennysheth@hotmail.com
authors.forename: Frenny
authors.initials: F
authors.lastname: Sheth
authors.forename: Subhada
authors.initials: S
authors.lastname: Rao
authors.forename: Manisha
authors.initials: M
authors.lastname: Desai
authors.forename: Jigna
authors.initials: J
authors.lastname: Vin
authors.forename: Jayesh
authors.initials: J
authors.lastname: Sheth
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D020732:Cytogenetic Analysis; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age