title: Organotin(IV) complexes of 2-pyridineformamide-derived thiosemicarbazones: antimicrobial and cytotoxic effects.
abstract: Reaction of n-butyltin trichloride [(n-Bu)SnCl(3)] with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives gave [(n-Bu)Sn(2Am4DH)Cl(2)] (1), [(n-Bu)Sn(2Am4Me)Cl(2)] (2), and [(n-Bu)Sn(2Am4Et)Cl(2)] (3). Thiosemicarbazones as well as their tin complexes are active as antimicrobials against the growth of Candida albicans and Salmonella typhimurium and were highly active against malignant glioblastoma. The cytotoxic activity of complexes 1-3 is similar. Among the studied compounds [(n-Bu)Sn(2Am4DH)Cl(2)] (1) was the most active as antiproliferative (cytostatic) agent. Thiosemicarbazones and their tin(IV) complexes proved to be more potent as cytotoxic agents than cisplatin. All the compounds were able to induce apoptosis.
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Isolda C
authors.initials: IC
authors.lastname: Mendes
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Moreira
authors.forename: José D
authors.initials: JD
authors.lastname: Ardisson
authors.forename: Raquel Gouvea Dos
authors.initials: RG
authors.lastname: Santos
authors.forename: Paulo Roberto O
authors.initials: PR
authors.lastname: da Silva
authors.forename: Isabel
authors.initials: I
authors.lastname: Garcia
authors.forename: Alfonso
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: Heloisa
authors.initials: H
authors.lastname: Beraldo
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005559:Formamides / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009947:Organotin Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: C532279:2-pyridineformamide; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005559:Formamides; D009947:Organotin Compounds; D011725:Pyridines; D013882:Thiosemicarbazones