title: Histopathologic and trypsin digestion studies of the retina in incontinentia pigmenti.
abstract: OBJECTIVE
  To report the ocular histopathologic features of a 55-year-old patient with incontinentia pigmenti retinopathy.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 55-year-old patient with incontinentia pigmenti retinopathy.
  
  
  METHODS
  Examination of eyes by light microscopy and retinal trypsin digestion.
  
  
  METHODS
  Clinical and histopathological findings.
  
  
  RESULTS
  Histopathologic examination disclosed inner retinal ischemic atrophy, capillary beading, arteriolar-venous anastomoses, preretinal neovascularization, vasculopathy located at the junction of central vascular and peripheral avascular retina, retinal tears, and tractional retinoschisis.
  
  
  CONCLUSIONS
  Patients with retinal manifestations of incontinentia pigmenti may progress to proliferative vitreoretinopathy or retinal detachment and should be observed closely over the course of their lifetime.
authors.affiliation: Eye Pathology Laboratory, Department of Pathology, Wilmer Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: W Robert
authors.initials: WR
authors.lastname: Bell
authors.forename: W Richard
authors.initials: WR
authors.lastname: Green
authors.forename: Morton F
authors.initials: MF
authors.lastname: Goldberg
mesh_terms: D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007184:Incontinentia Pigmenti / Q000175:diagnosis*; D008875:Middle Aged; D012160:Retina / Q000187:drug effects; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*; D014357:Trypsin / Q000494:pharmacology*
chemical_list: D014357:Trypsin