Pharmacological activity of cardiovascular agents from herbal medicine.
Some of the active phytochemicals in herbal medicine are finding therapeutic use. For example, patients with heart disease are reported to benefit from treatment with herbal medicine with fewer side effects. Previous studies showed the inhibitory effects of tetramethylpyrazine, an active component of medicinal herb, on phosphodiesterase that is associated with heart disease and the cardio-protective effects of other herbal medicine that was used to protect ischemia-reperfusion injury of rat hearts. Individual herbal medicines show antipyretic, analgesic and anti-inflammatory and anti-cancer effects. In addition to sharing many therapeutic activities, the active components of herbal medicine are also used in nutrient supplement for cardiovascular disease. Numerous in vitro studies of herbal medicine on different cell lines and in vivo study of herbal medicine have been reported. However, the mechanism of actions remains unclear. The present review aims to give an overview of the recent development of herbal medicine in treatment of cardiovascular disease, and covers the possible mechanism of action of some of active principles. The study will provide insights into drug action and demonstrate the therapeutic benefits of herbal medicine for the treatment of cardiovascular disease.
Ho
John W
JW
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong. b678738@mailserv.cuhk.edu.hk
Jie
Meng
M
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D027885:Astragalus propinquus / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000494:pharmacology; D029001:Herbal Medicine; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology
D000470:Alkaloids; D001713:Biphenyl Compounds; D002317:Cardiovascular Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D017705:Lignans; D010616:Phenanthrenes; D011719:Pyrazines; C005498:magnolol; C024894:tanshinone II A sodium sulfonate; D019695:Glycyrrhizic Acid; C017953:tetramethylpyrazine; C056599:icariin