title: Palladium coupling catalysts for pharmaceutical applications.
abstract: This review discusses recent advances made in the area of palladium-catalyzed coupling reactions and describes a selection of the catalytic systems that are useful in the preparation of valuable compounds for the pharmaceutical industry. Most of these types of syntheses have used either simple palladium salts or palladium precursors associated with electron-rich mono- or bidentate phosphine ligands as catalysts. For some reactions, ligands such as triphenyl phosphine, 1,1'-bis(diphenylphosphino)ferrocene, a carbene or a bipyridine have also been employed. Several new procedures for the Suzuki cross-coupling reaction, the activation of aryl chlorides, the functionalization of aromatics and the synthesis of heteroaromatics are discussed. The C-H activation/ functionalization reactions of aryl and heteroaryl derivatives have emerged as powerful tools for the preparation of biaryl compounds, and the recent procedures and catalysts employed in this promising field are also highlighted herein.
authors.affiliation: Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes, Catalyse et Organométalliques, Campus de Beaulieu, Rennes, France. henri.doucet@univ-rennes1.fr
authors.forename: Henri
authors.initials: H
authors.lastname: Doucet
authors.forename: Jean-Cyrille
authors.initials: JC
authors.lastname: Hierso
mesh_terms: D002384:Catalysis; D015195:Drug Design; D004345:Drug Industry / Q000379:methods* / Q000639:trends; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D010165:Palladium