[Non-Hodgkin's lymphoma of the prostate: a report of 2 cases and review of the literature].
OBJECTIVE
To study the clinicopathological characteristics of primary Non-Hodgkin's Lymphoma (NHL) of the prostate.


METHODS
Two cases of primary NHL of the prostate were studied by analyzing the clinical data, pathological features, prognosis and review of the literature.


RESULTS
HE showed that the normal prostatic tissues were replaced by diffuse-type cancer tissues composed of oval or round medium- to large- size lymphoid cells, with vesicular nuclei, fine chromatin, 2-4 membrane-bound nucleoli and scanty cytoplasm, with either amphophilic or basophilic. Immunohistochemistry revealed: CD20 +, CD79a +, CD10 -, CD5 -, CD3 - and CD45 - in Case 1 and CD20+ + +, PSA +/-, CKpan -, Syn -, CgA -, 34betaE12 -, P504S - and CD3 - in Case 2. Case 1 received chemotherapy combined with radiotherapy, relapsed 4 years later and stabilized by repeated chemotherapy. Case 2 experienced no recurrence after treated by chemotherapy.


CONCLUSIONS
Surgical treatment could be avoided by preoperative pathological diagnosis of primary NHL of the prostate, for which combined chemotherapy should be the first preference.
Shen
Xiao-Jian
XJ
Department of Pathology, Nanjing General Hospital of Nanjing Command, PLA , Nanjing, Jiangsu 210002, China.
Zheng
Xiao-Gang
XG
Zhou
Xiao-Jun
XJ
Zhou
Hang-Bo
HB
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D018951:Antigens, CD20