[Is it possible to reduce the incidence of preeclampsia in pregnant women with type I diabetes mellitus].
OBJECTIVE
To follow the meaning of diabetic metabolic control in the early pregnancy springing up the preeclampsia (PR) in pregnant women with type I diabetes mellitus (T1DM).


METHODS
A prospective study has been done among 105 pregnant women with T1DM. The diabetic pregnant have been divided into two groups: 1st group--43 women with preplanning pregnancy and 2nd group--62 women with non-planning pregnancy.


RESULTS
There was no difference in the frequency of PR among women with planning and non-planning pregnancy (25.6% vs. 30.6%; P=0.36). The mild and moderate cases of PR among the women with planning pregnancy are prevailing, while moderate and severe cases of PR were observed in non-planning pregnancy. In pregnant women with planning pregnancy there is no difference between the initial level HbA1c of women without PR and PR (7%+/-0.7 vs. 7.1%+/-0.9%; P=0.13). Pregnant women with non-planning pregnancy have significantly higher initial level of HbA1c (9.7%+/-1.7 vs. 8.3%+/-1.3%; P=0.01). Pregnant women with PR have significantly higher body weight, creatinin, diurnal urine albumin excretion and diurnal insulin dose.


CONCLUSIONS
The chronicle hyperglycemia in the early pregnancy in combination with the established factors are increasing the risk of preeclampsia in women with non-planning pregnancy and poor glycaemic control.
Todorova
K
K
Ivanov
S
S
Genova
M
M
Batashki
I
I
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005193:Family Planning Services / Q000706:statistics & numerical data; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015994:Incidence; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human