title: Li-cadherin is inversely correlated with galectin-3 expression in gastric cancer.
abstract: The aims of this study were to examine the expressions of Li-cadherin and Galectin-3 in gastric cancer, and the correlation between Li-cadherin and Galectin-3 in gastric cancer was also analyzed. The present study investigated the expression level of Li-cadherin and Galectin-3 by immunohistochemistry and semiquantitative polymerase chain reaction (PCR), and correlated this with clinicopathologic parameters in 91 cases of gastric cancer. The correlation between expression levels of Li-cadherin and Galectin-3 was analyzed by Spearman correlation analysis. The expression level of Li-cadherin mRNA was correlated to differentiation and lymph node metastasis, and the expression level of Galectin-3 was related to TNM staging, differentiation and lymph node metastasis. On Spearman correlation analysis, a definitive negative correlation was found between the expression levels of Li-cadherin and Galectin-3 in gastric cancerous tissues. We postulate that interaction between Li-cadherin and Galectin-3 may play an important role in the development of gastric cancer.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, JieFang Road 238, WuHan 430060, PR China. dongwg66@yahoo.com.cn
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Dong
authors.forename: Qiong-Fang
authors.initials: QF
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015820:Cadherins / Q000378:metabolism*; D002454:Cell Differentiation; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: C490584:CDH17 protein, human; D015820:Cadherins; D037502:Galectin 3