Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior.
Fast-scan cyclic voltammetry on freely moving rats was used to determine whether a correlation exists between the increase in stereotyped behavior and dopamine (DA) uptake inhibition following cocaine (20 mg/kg, i.p.) administration. Voltammetric recordings were performed every 100 ms at a carbon fiber microelectrode, positioned in the nucleus accumbens. The present experiments revealed that the time course of the changes in K(m) strictly parallels the time course of the increase in stereotypy after cocaine. More importantly, the magnitudes of cocaine-stimulated stereotypy were positively and significantly correlated with the K(m) increases. Therefore, these data closely link the DA transporter inhibition with cocaine-induced stereotypy.
Budygin
Evgeny A
EA
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, United States. ebudygin@wfubmc.edu
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage*; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D018765:Dopamine Uptake Inhibitors; D003042:Cocaine; D004298:Dopamine