title: Long-term remission of primary gastric T cell lymphoma associated with human T lymphotropic virus type 1: a report of two cases and review of the literature.
abstract: Two cases of primary gastric T-cell lymphoma associated with human T lymphotropic virus type 1 (HTLV-1) are presented. Case 1 was a 54-year-old man who had multiple ulcerating tumors in the lower corpus and gastric antrum. Case 2, a 60-year-old man, showed a large ulcerating tumor in the upper corpus. Both patients were positive for serum anti-HTLV-1 antibody and for the monoclonal integration of HTLV-1 proviral DNA in the tumor cells by Southern blot analysis. The patients were thus diagnosed as having primary gastric T-cell lymphoma associated with HTLV-1 of stage II(1). Case 1 underwent total gastrectomy followed by chemotherapy, while Case 2 was treated by chemotherapy and radiotherapy. Both patients have been in complete remission for more than 4 years (96 months in Case 1 and 50 months in Case 2) after the treatments. Although primary gastric T-cell lymphomas associated with HTLV-1 is characterized by an extremely poor prognosis, the present cases suggest that in the early stage, long-term survival can possibly be achieved with appropriate treatments.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. k-ichi@intmed2.med.kyushu-u.ac.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Katsuya
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Yanaru-Fujisawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Onoyama
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Sakata
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D015490:HTLV-I Infections / Q000097:blood / Q000150:complications; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000628:therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology
chemical_list: D000914:Antibodies, Viral