title: Quinoline derivatives: potential antiparasitic and antiviral agents.
abstract: The crystal structures of closely related quinoline compounds substituted at the 2-position by a vinyl group, either including a Cl atom [2-(1-chloro-2-methylprop-1-enyl)-8-nitroquinoline, C(13)H(11)ClN(2)O(2), (I)] or not [2-(2-methylprop-1-enyl)-8-nitroquinoline, C(13)H(12)N(2)O(2), (II)], show an important deviation of the vinyl group from coplanarity with the quinoline ring system if the Cl atom is present. The nitro group is perpendicular [in (II)] or nearly so [in (I)] to the quinoline ring system. In (II), all non-H atoms except the nitro O atoms are located on a crystallographic mirror plane.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen, 5 rue Vaubénard, 14032 Caen, France. jana.sopkova@unicaen.fr
authors.forename: Jana
authors.initials: J
authors.lastname: Sopková-de Oliveira Santos
authors.forename: Pierre
authors.initials: P
authors.lastname: Verhaeghe
authors.forename: Jean François
authors.initials: JF
authors.lastname: Lohier
authors.forename: Pascal
authors.initials: P
authors.lastname: Rathelot
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D000977:Antiparasitic Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009600:Nitroquinolines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: C526031:2-(1-chloro-2-methylprop-1-enyl)-8-nitroquinoline; C526032:2-(2-methylprop-1-enyl)-8-nitroquinoline; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D009600:Nitroquinolines; D011804:Quinolines