title: [Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine].
abstract: This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine. Patients with a diagnosis of malaria caused by Plasmodium vivax or the V+F mixture (Plasmodium vivax + Plasmodium falciparum) were selected. Group 1 consisted of 74 individuals with a clinical diagnosis of methemoglobinemia and Group 2 consisted of 161 individuals without a clinical diagnosis of methemoglobinemia. The glucose-6-phosphate dehydrogenase deficiency rates (numbers of enzymopenic individuals) in Groups 1 and 2 were 51.3% (38) and 8.7% (14) respectively. These data demonstrated a statistically significant association with methemoglobinemia only among the individuals in Group 1 (p<0.05). Investigation of the relationship between methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency showed that there was a possible association such that enzymopenic individuals may develop methemoglobinemia more frequently.
authors.affiliation: Gerência de Malária, Fundação de Medicina Tropical do Amazonas, Avenida Pedro Teixeira 25, Bairro D. Pedro I, Manaus, AM. marli.maciel@uol.com.br
authors.forename: Marli Stela
authors.initials: MS
authors.lastname: Santana
authors.forename: Marcos Antonio Ferreira
authors.initials: MA
authors.lastname: da Rocha
authors.forename: Ana Ruth Lima
authors.initials: AR
authors.lastname: Arcanjo
authors.forename: José Felipe Jardim
authors.initials: JF
authors.lastname: Sardinha
authors.forename: Wilson Duarte
authors.initials: WD
authors.lastname: Alecrim
authors.forename: Maria das Graças Costa
authors.initials: Md
authors.lastname: Alecrim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000201:enzymology; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D011319:Primaquine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D011319:Primaquine