Evaluation of higher order ocular aberrations in patients with keratoconus.
OBJECTIVE
To describe higher order ocular aberrations in eyes with keratoconus.


METHODS
Prospective, observational, case-control study comparing higher order ocular aberrations in patients with keratoconus with control subjects with myopia.


RESULTS
One hundred sixteen patients with keratoconus were recruited. Data were analyzed in 35 keratoconus eyes, 38 keratoconus suspect eyes, and 166 right eyes with myopia. Mean total higher order root-mean-square (RMS) values (3rd to 5th order) were 1.73 +/- 0.71 microm in eyes with keratoconus, 0.94 +/- 0.66 microm in eyes with keratoconus suspect, and 0.49 +/- 0.16 microm in control eyes. Keratoconus eyes had greater total higher order RMS, 3rd to 5th order RMS, and RMS for all Zernike terms than those in the control group (P < .001).


CONCLUSIONS
Keratoconus and keratoconus suspect eyes had significantly larger higher order aberrations in total higher order RMS and 3rd order RMS than control eyes.
Lim
Li
L
Singapore National Eye Centre, Singapore, PR China. lim_li@snec.com.sg
Wei
Rui Hua
RH
Chan
Wing Kwong
WK
Tan
Donald T H
DT
D000293:Adolescent; D000328:Adult; D002648:Child; D003261:Contact Lenses; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017755:Prosthesis Fitting; D011788:Quality of Life; D012030:Refractive Errors / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology