title: Simulation of the interaction between blood flow and atherosclerotic plaque.
abstract: It has been well accepted that over 50% of cerebral ischemic events are the result of rupture of vulnerable carotid atheroma and subsequent thrombosis. Such strokes are potentially preventable by carotid interventions. Selection of patients for intervention is currently based on the severity of carotid luminal stenosis. It has been, however, widely accepted that luminal stenosis alone may not be an adequate predictor of risk. To evaluate the effects of degree of luminal stenosis and plaque morphology on plaque stability, we used a coupled nonlinear time-dependent model with flow-plaque interaction simulation to perform flow and stress/strain analysis for stenotic artery with a plaque. The Navier-Stokes equations in the Arbitrary Lagrangian-Eulerian (ALE) formulation were used as the governing equations for the fluid. The Ogden strain energy function was used for both the fibrous cap and the lipid pool. The plaque Principal stresses and flow conditions were calculated for every case when varying the fibrous cap thickness from 0.1 to 2 mm and the degree of luminal stenosis from 10% to 90%. Severe stenosis led to high flow velocities and high shear stresses, but a low or even negative pressure at the throat of the stenosis. Higher degree of stenosis and thinner fibrous cap led to larger plaque stresses, and a 50% decrease of fibrous cap thickness resulted in a 200% increase of maximum stress. This model suggests that fibrous cap thickness is critically related to plaque vulnerability and that, even within presence of moderate stenosis, may play an important role in the future risk stratification of those patients when identified in vivo using high resolution MR imaging.
authors.affiliation: Department of Radiology and Engineering, University of Cambridge, Cambridge, UK. ZYL22@cam.ac.uk
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Li
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Gillard
mesh_terms: D000465:Algorithms; D050197:Atherosclerosis / Q000175:diagnosis* / Q000473:pathology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D003198:Computer Simulation; D004548:Elasticity; D004867:Equipment Design; D020342:Finite Element Analysis; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008955:Models, Cardiovascular; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D012306:Risk; D012984:Software; D013927:Thrombosis
chemical_list: D008055:Lipids