title: Modeling pain circuits: how imaging may modify perception.
abstract: Pain is the unpleasant sensory experience following tissue damage or the threat of damage. The activation of cortical regions during noxious stimulation is believed a result of the negative affect and sensations generated by the stimulus. How a noxious event is translated into pain experience remains uncertain, and pain that occurs in the absence of a noxious event remains mysterious. Acute pain and chronic pain depend on a categorization of feeling that occurs collectively rather than individually. Capturing that process inside a brain scan is problematic. Resolving this problem requires an approach to imaging that transgress the boundaries of physical and social concepts.
authors.affiliation: University of Birmingham, School of Psychology, Edgbaston B15 2TT, United Kingdom. s.w.derbyshire@bham.ac.uk
authors.forename: Stuart W G
authors.initials: SW
authors.lastname: Derbyshire
authors.forename: Jody
authors.initials: J
authors.lastname: Osborn
mesh_terms: D001921:Brain / Q000166:cytology / Q000502:physiology*; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways; D010146:Pain / Q000503:physiopathology*; D010465:Perception / Q000502:physiology*