Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans.
1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.
Kelly
J J
JJ
Department of Medicine, University of New South Wales, St George Hospital, Sydney, NSW, Australia.
Tam
S H
SH
Williamson
P M
PM
Whitworth
J A
JA
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000627:therapeutic use*
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D005996:Nitroglycerin; D006854:Hydrocortisone