Hair analysis to document non-fatal pesticide intoxication cases.
We reported two non-fatal cases of intoxication with pesticides namely alachlor and carbofuran. Hair stand samples were collected from two men approximately 1 year after alachlor intoxication for case 1, and 14 days after the last exposure for case 2. Hair analysis was performed using a liquid chromatography-tandem mass spectrometry method. In case 1, alachlor was detected in the 5 analysed hair segments (concentrations between 12 and 136 pg/mg) and its metabolites were not detected. In case 2, carbofuran and its main metabolite (3-hydroxycarbofuran) were detected in the hair strand (global analysis) at the concentrations of 207 and 164 pg/mg, respectively. However, additional data are required in order to interpret such results.
Dulaurent
S
S
Department of Pharmacology and Toxicology, University Hospital, 2 Avenue Martin Luther King, 87025 Limoges, France. sylvain.dulaurent@unilim.fr
Gaulier
J M
JM
Baudel
J L
JL
Fardet
L
L
Maury
E
E
Lachâtre
G
G
D000081:Acetamides / Q000032:analysis*; D000328:Adult; D002235:Carbofuran / Q000031:analogs & derivatives / Q000032:analysis*; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010575:Pesticides / Q000032:analysis*
D000081:Acetamides; D010575:Pesticides; C000188:alachlor; C028403:3-hydroxycarbofuran; D002235:Carbofuran