title: From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.
abstract: I have been invited to write a short historical feature in the context of being a co-recipient with Klaus Rajewsky and Fritz Melchers of the 2007 Novartis Prize in Basic Immunology that was given in the general area of the molecular biology of B cells. In this feature, I cover the main points of the short talk that I presented at the Award Ceremony at the International Immunology Congress in Rio de Janeiro, Brazil. This talk focused primarily on the work and people involved early on in generating the models and ideas that have formed the basis for my ongoing efforts in the areas of V(D)J recombination and B cell development.
authors.affiliation: Howard Hughes Medical Institute, The Children's Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, Boston, MA 02215, USA. Alt@enders.tch.harvard.edu
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Alt
mesh_terms: D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics* / Q000276:immunology; D005784:Gene Amplification / Q000276:immunology*; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain / Q000276:immunology*; D049673:History, 20th Century; D006801:Humans