ESCRTing proteins in the endocytic pathway.
The endosomal sorting complex required for transport (ESCRT) machinery is highly conserved and its components have been found in all five major supergroups of eukaryotes. The three ESCRT complexes and associated proteins play critical roles in receptor downregulation, retroviral budding, and other normal and pathological cellular processes. Besides monoubiquitin-dependent protein cargo recognition and sorting, the ESCRT machinery also appears to drive the formation of multivesicular bodies (MVBs). Recent advances in the determination of the function and structure of the ESCRT complexes have improved our understanding of the molecular details underlying the assembly and regulation of the ESCRT machinery.
Saksena
Suraj
S
Cornell Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Sun
Ji
J
Chu
Tony
T
Emr
Scott D
SD
D004705:Endocytosis; D008958:Models, Molecular; D011487:Protein Conformation; D021382:Protein Sorting Signals; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
D021382:Protein Sorting Signals; D011506:Proteins; D025801:Ubiquitin