Visualizing white matter pathways in the living human brain: diffusion tensor imaging and beyond.
Biologic connectionism holds as its central tenet that the cognitive, behavioral, and motor functions of the brain are derived from the complex interconnections of simple neural processing units. Much can be learned about the human mind through the study of the brain's connections in normal and diseased states. This article summarizes the essential features of the tensor model of diffusion, outlines newer approaches to overcoming the limitations of the tensor, and provides normal and clinical examples of white matter anatomy derived using diffusion tensor imaging and more sophisticated high angular resolution diffusion imaging methods. Diffusion MR imaging is a powerful adjunct to techniques for studying brain function.
Hess
Christopher P
CP
Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143-0628, USA.
Mukherjee
Pratik
P
D001921:Brain / Q000166:cytology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D009434:Neural Pathways