title: New physiological model of serum creatine phosphokinase activity in acute myocardial infarction. Estimation of the total creatine phosphokinase release.
abstract: In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.
authors.affiliation: Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, Japan. kitawaki@md.okayama-u.ac.jp
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kitawaki
authors.forename: Hisao
authors.initials: H
authors.lastname: Oka
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Himeno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003198:Computer Simulation; D003402:Creatine Kinase / Q000097:blood*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D003402:Creatine Kinase