One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using aldehydes.
One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using various aldehydes by Pd/C catalyst in aqueous 2-propanol solvent with ammonium formate as in situ hydrogen donor is illustrated. The reaction proceeded smoothly and selectively with excellent yield at room temperature. Our protocol presents a facile, economical, and environmentally benign alternative for reductive amination.
Byun
Eunyoung
E
Hanyang University, Department of Chemistry and Applied Chemistry Ansan Sangrok-Gu Sa-3-Dong 1271, Kyunggi-Do 426-791, Korea.
Hong
Bomi
B
De Castro
Kathlia A
KA
Lim
Minkyung
M
Rhee
Hakjune
H
D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis*; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D000814:Aniline Compounds; D009578:Nitrobenzenes; D010165:Palladium; D002244:Carbon