[Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia?].
Pregabalin is similar in structure to gamma-aminobutyric acid. It is used for neuropathic pain, generalized anxiety disorders and as an adjunct therapy for partial seizures. Tachycardia is a rare side-effect. A 92-year-old patient with a history of paroxystic fibrillation was hospitalised for zoster. She developed a sinusal tachycardia followed by atrial fibrillation and congestive heart failure 15 h after a first dose of pregabalin. The imputation was considered as plausible. Even though the mechanism remains unclear, pregabalin might induce tachycardia in predisposed old patients.
Laville
M-A
MA
Centre régional de pharmacovigilance de Basse-Normandie, CHRU Côte-de-Nacre, 14033 Caen cedex, France. lavillema@yahoo.fr <lavillema@yahoo.fr>
de la Gastine
B
B
Husson
B
B
Le Boisselier
R
R
Mosquet
B
B
Coquerel
A
A
D000369:Aged, 80 and over; D000588:Amines / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000139:chemically induced*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D006333:Heart Failure / Q000139:chemically induced; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D009443:Neuritis / Q000188:drug therapy; D000069583:Pregabalin; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin