Computational model of atrial electrical activation and propagation.
We have developed a finite-element surface model of human atria, in order to study normal and abnormal patterns of atrial activation. To characterize electrical activity in both atrial muscle and cardiac pacemaker regions, Fitzhugh-Nagumo-type equations were employed. Model equations were tested using a simplified geometry containing major topological features of both atria. The model is able to generate spontaneous activation of electrical impulses within the sinoatrial node which propagate across the atria. The model can be used as a basis for investigating mechanisms underlying normal and abnormal atrial rhythms, including re-entrant activation by an ectopic focus.
Dokos
Socrates
S
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, Australia. s.dokos@unsw.edu.au
Cloherty
Shaun L
SL
Lovell
Nigel H
NH
D000200:Action Potentials / Q000502:physiology*; D016275:Atrial Function / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology*; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular