title: A 9 year-old girl with herpes simplex virus type 2 acute retinal necrosis treated with intravitreal foscarnet.
abstract: A 9-year-old girl presented with a 2-week history of redness in the left eye. Examination revealed vitritis, retinal whitening, vasculitis, and optic nerve head edema. Polymerase chain reaction testing of the aqueous fluid revealed herpes simplex virus type 2. The retinitis was controlled with intravenous acyclovir and intravitreal foscarnet. The clinical course was complicated by retinal neovascularization and vitreous hemorrhage, which was treated by pars plana vitrectomy and endolaser. While there are few case reports of herpes simplex virus type 2 retinitis in children, this one is unique for the following reasons: it is the first reported case of herpes simplex virus type 2 retinitis in a child less than 10 years old without a previous history of neonatal infection or central nervous system involvement; no other children have been reported to have been treated with intravitreal foscarnet; and retinal neovascularization complicated the recovery.
authors.affiliation: Retina and Vitreous Service, University of Rochester Eye Institute, Rochester, New York 14642, USA.
authors.forename: John
authors.initials: J
authors.lastname: King
authors.forename: Mina
authors.initials: M
authors.lastname: Chung
authors.forename: David A
authors.initials: DA
authors.lastname: DiLoreto
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage* / Q000627:therapeutic use; D005654:Fundus Oculi; D006561:Herpes Simplex / Q000188:drug therapy*; D018258:Herpesvirus 2, Human; D006801:Humans; D007275:Injections, Intravenous; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000601:surgery; D015882:Retinal Necrosis Syndrome, Acute / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D012171:Retinal Vessels; D014463:Ultrasonography; D014821:Vitrectomy; D014822:Vitreous Body; D014823:Vitreous Hemorrhage / Q000209:etiology / Q000601:surgery
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir