CSF hypocretin-1 levels are normal in multiple-system atrophy.
Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.
Abdo
W F
WF
Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P.O. Box 9101, 6500 Nijmegan, HB, The Netherlands.
Bloem
B R
BR
Kremer
H P H
HP
Lammers
G J
GJ
Verbeek
M M
MM
Overeem
S
S
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000134:cerebrospinal fluid* / Q000145:classification; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins