title: Acute Marchiafava-Bignami disease with widespread callosal and cortical lesions.
abstract: Marchiafava-Bignami disease (MBD) is a rare alcohol-related disorder that results in progressive demyelination and necrosis of the corpus callosum. The process may extend to the optic chiasm and tracts, cerebellar peduncle, subcortical resion, neighboring white matter, and rarely, cortical gray matter. We report a case of MBD in which fluid-attenuated inversion recovery and diffusion magnetic resonance imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex in addition to the callosal lesions.
authors.affiliation: Department of Neurology, Kosin University College of Medicine, Busan, Korea.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong-Kuk
authors.initials: JK
authors.lastname: Kim
authors.forename: Bong-Goo
authors.initials: BG
authors.lastname: Yoo
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Young Duk
authors.initials: YD
authors.lastname: Jo
mesh_terms: D000437:Alcoholism / Q000150:complications; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000473:pathology; D009897:Optic Chiasm / Q000473:pathology; D012640:Seizures; D013997:Time Factors; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex