In vivo methods for the assessment of topical drug bioavailability.
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
Herkenne
Christophe
C
School of Pharmaceutical Sciences, University of Geneva, Geneva 4, Switzerland.
Alberti
Ingo
I
Naik
Aarti
A
Kalia
Yogeshvar N
YN
Mathy
François-Xavier
FX
Préat
Véronique
V
Guy
Richard H
RH
D000287:Administration, Topical; D000465:Algorithms; D001682:Biological Availability; D006801:Humans; D017551:Microdialysis; D018613:Microscopy, Confocal; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D010599:Pharmacokinetics; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
D004364:Pharmaceutical Preparations