Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis.
OBJECTIVE
Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, in part, for genetic susceptibility to endometriosis.


METHODS
The KIRs genotype was determined in 186 patients with endometriosis and 165 control women using polymerase chain reaction with sequence-specific primers.


RESULTS
The frequency of KIR3DS1 was significantly decreased in patients compared with controls (32% versus 44%, P=0.028). KIR data were analyzed using a model comprised of three large groups, in which a gradient of activation/inhibitory potential derived from the combination of KIR and human leukocyte antigen (HLA) ligand genes was taken into account. The frequency of inhibitory KIRs/HLA-class I combination genotypes was significantly higher in patients than in controls (chi2=6.010, 2 df, P=0.0496).


CONCLUSIONS
Our results suggest that polymorphism in KIRs may be associated with susceptibility for endometriosis.
Kitawaki
Jo
J
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. kitawaki@koto.kpu-m.ac.jp
Xu
Bing
B
Ishihara
Hiroaki
H
Fukui
Michiaki
M
Hasegawa
Goji
G
Nakamura
Naoto
N
Mizuno
Shigeto
S
Ohta
Mitsuhiro
M
Obayashi
Hiroshi
H
Honjo
Hideo
H
D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005805:Genes, MHC Class I / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology*
D054340:Receptors, KIR