Multicystic adenomatoid hamartoma of the pancreas: a hitherto undescribed pancreatic tumor occurring in a 3-year-old boy.
This report describes an unusual pancreatic tumor in a 3-year-old boy. He presented with abdominal pain secondary to pancreatitis and was found to have a complex, multicystic lesion within the head of the pancreas. He subsequently underwent a pancreatoduodenectomy. Grossly, the mass was 3 cm, multicystic, and well demarcated. Histologically, there were numerous variably sized, dilated ducts lined by tall columnar mucinous cells surrounded by a stroma that exhibited foci of cellular condensations resembling primitive pancreatic mesenchyme. Acinar and endocrine cells were often seen budding into the ducts forming "ductulo-insular bodies." As a result of its superficial resemblance to Stocker type 2 cystic adenomatoid malformation of the lung, we are proposing the name "multicystic adenomatoid hamartoma" for this lesion.
Thrall
Michael
M
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Jessurun
Jose
J
Stelow
Edward B
EB
Adsay
N Volkan
NV
Vickers
Selwyn M
SM
Whitson
Amy K
AK
Saltzman
Daniel A
DA
Pambuccian
Stefan E
SE
D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation; D002675:Child, Preschool; D018572:Disease-Free Survival; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D053552:Keratin-7 / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010182:Pancreatic Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy
D015415:Biomarkers; D053552:Keratin-7