title: Thermal and storage stability of nutraceuticals in a milk beverage dietary supplement.
abstract: Under the Dietary Supplement Health and Education Act (DSHEA), fluid skim milk can be used to serve as a vehicle to deliver certain metabolites (nutraceuticals or new dietary ingredients), which provide health benefits as related to aging problems for those over 55. This opens a new avenue for an increase in milk consumption and may replace taking pills. Milk beverages enriched with various nutraceutical ingredients (soy isoflavones, glucosamine, chondroitin sulfate, creatine, and lactoferrin) were thermally processed at different combinations of temperatures from 72 to 138 degrees C for different holding times using a Microthermics pilot plant thermal processing unit and were incubated at refrigeration, room, or elevated storage temperatures. Residual concentrations of the active compounds were measured by high performance liquid chromatography or by immunodifusion (for lactoferrin) and degradation kinetics were determined. Results showed a very good stability of isoflavones and chondroitin sulfate in the milk environment while glucosamine, lactoferrin, and creatin showed only limited stability at either processing or storage. Glucosamine destabilized the milk protein system at boiling temperature or higher, which caused drastic precipitation in the heat exchangers. Nevertheless, all the tested nutraceutical compounds can be used to design milk beverage dietary supplements but an overrun of over 25% may be required for some of them.
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, FScN, 1334 Eckles Ave., St. Paul, MN 55108, USA. MichaelU@taramilk.co.il
authors.forename: M
authors.initials: M
authors.lastname: Uzzan
authors.forename: J
authors.initials: J
authors.lastname: Nechrebeki
authors.forename: T P
authors.initials: TP
authors.lastname: Labuza
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001628:Beverages / Q000032:analysis* / Q000592:standards; D002809:Chondroitin Sulfates / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000032:analysis; D019587:Dietary Supplements; D004355:Drug Stability; D005519:Food Preservation / Q000379:methods*; D005527:Food, Fortified / Q000032:analysis* / Q000592:standards; D005944:Glucosamine / Q000032:analysis; D006358:Hot Temperature; D006801:Humans; D005779:Immunodiffusion; D007529:Isoflavones / Q000032:analysis; D007700:Kinetics; D007781:Lactoferrin / Q000032:analysis; D008875:Middle Aged; D008892:Milk / Q000737:chemistry* / Q000592:standards; D009751:Nutritional Requirements; D013997:Time Factors
chemical_list: D007529:Isoflavones; D002809:Chondroitin Sulfates; D007781:Lactoferrin; D003401:Creatine; D005944:Glucosamine