Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents.
Tetrapyrrole ethanolamide derivatives, 1 and 2, were prepared from hematoporphyrin IX (HPIX, 3) and methyl pheophorbide a (mPheo, 6). These were evaluated for their dual action as chemotherapeutics and photosensitizers in treatment of cancer. The novel compounds showed significant in vitro anticancer activity as measured in different cell lines using the MTT assay and photodynamic activity measured by erythrocytes' photohemolysis.
Girard
Denis
D
Département de Chimie-Biologie, Université du Québec à Trois-Rivières, Trois-Rivières, Que., Canada G9A 5H7.
Weagle
Glenn
G
Gupta
Atul
A
Bérubé
Gervais
G
Chapados
Camille
C
D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D000431:Ethanol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006415:Hematoporphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045725:Tetrapyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000577:Amides; D000970:Antineoplastic Agents; D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D045725:Tetrapyrroles; C093722:hematoporphyrin IX di-N-propyletherdiethanolamide; C553809:pheophorbide a ethanolamide; D002734:Chlorophyll; D000431:Ethanol