title: Integrin regulation of caveolin function.
abstract: Caveolae are unique organelles that are found in the plasma membrane of many cell types. They participate in various processes such as lipid recycling, cellular signalling and endocytosis. A variety of signalling molecules localize to caveolae in response to various stimuli, providing a potential mechanism for the spatial regulation of signal transduction pathways. Caveolin-1, a constitutive protein of caveolae, has been implicated in the regulation of cell growth, lipid trafficking, endocytosis and cell migration. Phosphorylation of caveolin-1 on Tyr 14 is involved in integrin-regulated caveolae trafficking and also in signalling at focal adhesions in migrating cells. In this review, we focus on recent studies that describe the role of caveolin-1 in integrin signal transduction, and how this interplay links extracellular matrix anchorage to cell proliferation, polarity and directional migration.
authors.affiliation: Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
authors.forename: Iñigo J
authors.initials: IJ
authors.lastname: Salanueva
authors.forename: Ana
authors.initials: A
authors.lastname: Cerezo
authors.forename: Marta C
authors.initials: MC
authors.lastname: Guadamillas
authors.forename: Miguel A
authors.initials: MA
authors.lastname: del Pozo
mesh_terms: D000818:Animals; D022461:Caveolins / Q000378:metabolism*; D002465:Cell Movement; D004705:Endocytosis; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D022461:Caveolins; D016023:Integrins