title: Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin.
abstract: The purpose of this study was to compare susceptibilities of ear and skin Pseudomonas spp. isolates to enrofloxacin, marbofloxacin, and ciprofloxacin. Specimens were obtained from dogs examined in a veterinary dermatology referral hospital. Susceptibilities of ear isolates to enrofloxacin, marbofloxacin, and ciprofloxacin were 46.9%, 66.7%, and 75.0%, respectively. Susceptibilities of skin isolates to the same drugs were 76.2%, 81.0%, and 80.0%, respectively. Ear isolates were significantly less susceptible to enrofloxacin than to ciprofloxacin (P=0.021), and ear isolates were significantly less susceptible to enrofloxacin than were skin isolates (P=0.034). When fluoroquinolone resistance was present, ear isolates were significantly less susceptible to enrofloxacin than to ciprofloxacin (P<0.001) and marbofloxacin (P=0.014).
authors.affiliation: Animal Dermatology Clinic, 5610 Kearny Mesa Road, Suite B1, San Diego, California 92111, USA.
authors.forename: Brett Everett
authors.initials: BE
authors.lastname: Wildermuth
authors.forename: Craig E
authors.initials: CE
authors.lastname: Griffin
authors.forename: Wayne S
authors.initials: WS
authors.lastname: Rosenkrantz
authors.forename: Mona J
authors.initials: MJ
authors.lastname: Boord
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D010032:Otitis Externa / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D011549:Pseudomonas / Q000187:drug effects*; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D011711:Pyoderma / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D015363:Quinolones / Q000627:therapeutic use; D012189:Retrospective Studies; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D002939:Ciprofloxacin; C080260:marbofloxacin