Dissociable performance on scene learning and strategy implementation after lesions to magnocellular mediodorsal thalamic nucleus.
Monkeys with aspiration lesions of the magnocellular division of the mediodorsal thalamus (MDmc) are impaired in object-in-place scene learning, object recognition, and stimulus-reward association. These data have been interpreted to mean that projections from MDmc to prefrontal cortex are required to sustain normal prefrontal function in a variety of task settings. In the present study, we investigated the extent to which bilateral neurotoxic lesions of the MDmc impair a preoperatively learnt strategy implementation task that is impaired by a crossed lesion technique that disconnects the frontal cortex in one hemisphere from the contralateral inferotemporal cortex. Postoperative memory impairments were also examined using the object-in-place scene memory task. Monkeys learnt both strategy implementation and scene memory tasks separately to a stable level preoperatively. Bilateral neurotoxic lesions of the MDmc, produced by 10 x 1 microl injections of a mixture of ibotenate and NMDA did not affect performance in the strategy implementation task. However, new learning of object-in-place scene memory was substantially impaired. These results provide new evidence about the role of the magnocellular mediodorsal thalamic nucleus in memory processing, indicating that interconnections with the prefrontal cortex are essential during new learning, but are not required when implementing a preoperatively acquired strategy task. Thus, not all functions of the prefrontal cortex require MDmc input. Instead, the involvement of MDmc in prefrontal function may be limited to situations in which new learning must occur.
Mitchell
Anna S
AS
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom. anna.mitchell@psy.ox.ac.uk
Baxter
Mark G
MG
Gaffan
David
D
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D003216:Conditioning, Operant / Q000502:physiology*; D004193:Discrimination Learning; D005260:Female; D007839:Functional Laterality; D008253:Macaca mulatta; D008297:Male; D020645:Mediodorsal Thalamic Nucleus / Q000293:injuries / Q000502:physiology*; D009483:Neuropsychological Tests; D009498:Neurotoxins / Q000008:administration & dosage; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D012201:Reward
D009498:Neurotoxins