title: [(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.
abstract: A new group of CO-releasing molecules, CO-RMs, based on cyclopentadienyl iron carbonyls have been identified. X-Ray structures have been determined for [(eta-C(5)H(4)CO(2)Me)Fe(CO)(2)X], X = Cl, Br, I, NO(3), CO(2)Me, [(eta-C(5)H(4)CO(2)Me)Fe(CO)(2)](2), [(eta-C(5)H(4)CO(2)CH(2)CH(2)OH)Fe(CO)(2)](2) and [(eta-C(5)H(4)CO(2)Me)Fe(CO)(3)][FeCl(4)]. Half-lives for CO release, (1)H, (13)C, and (17)OC NMR and IR spectra have been determined along with some biological data for these compounds, [(eta-C(5)H(4)CO(2)CH(2)CH(2)OH)Fe(CO)(3)](+) and [[eta-C(5)H(4)(CH(2))(n)CO(2)Me]Fe(CO)(3)](+), n = 1, 2. More specifically, cytotoxicity assays and inhibition of nitrite formation in stimulated RAW264.7 macrophages are reported for most of the compounds analyzed. [(eta-C(5)H(5))Fe(CO)(2)X], X = Cl, Br, I, were also examined for comparison. Correlations between the half-lives for CO release and spectroscopic parameters are found within each group of compounds, but not between the groups.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, UKS3 7HF.
authors.forename: David
authors.initials: D
authors.lastname: Scapens
authors.forename: Harry
authors.initials: H
authors.lastname: Adams
authors.forename: Tony R
authors.initials: TR
authors.lastname: Johnson
authors.forename: Brian E
authors.initials: BE
authors.lastname: Mann
authors.forename: Philip
authors.initials: P
authors.lastname: Sawle
authors.forename: Rehan
authors.initials: R
authors.lastname: Aqil
authors.forename: Trevor
authors.initials: T
authors.lastname: Perrior
authors.forename: Roberto
authors.initials: R
authors.lastname: Motterlini
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006207:Half-Life; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
chemical_list: D002248:Carbon Monoxide