title: Stem cells.
abstract: The application of stem cells to regenerative medicine is one of the actual hot topics in biomedicine. This research could help the cure of a number of diseases that are affecting a large share of the population. Some good results in cell replacement have already been obtained (infarcted heart, diabetes, Parkinson disease), apart from those of more traditional applications like severe burns and blood tumors. We are now facing crucial questions in stem cell biology. One of the key questions is how a cell begins to proliferate or differentiate. Genome reprogramming, both following nuclear transfer and cytoplast action, will likely highlight some of the molecular mechanisms of cell differentiation and dedifferentiation. In turn, these clues should be useful to the production of populations of reprogrammed cells that could develop into tissues or, in the future, into proper organs. We will overview what stem cells are, what roles they play in normal developmental processes and how stem cells could have the potential to treat diseases.
authors.affiliation: Direzione Scientifica Fondazione IRCCS Policlinico San Matteo, Italy.
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Redi
authors.forename: Manuela
authors.initials: M
authors.lastname: Monti
authors.forename: Valeria
authors.initials: V
authors.lastname: Merico
authors.forename: Tui
authors.initials: T
authors.lastname: Neri
authors.forename: Mario
authors.initials: M
authors.lastname: Zanoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zuccotti
authors.forename: Silvia
authors.initials: S
authors.lastname: Garagna
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*