[Characteristic metabolic disturbances in the rat tissues caused by long-term use of alcohol].
In the researches carried out on rats with models of chronic alcoholism and alcohol abstinence the most vulnerable to chronic action of alcohol biochemical parameters are revealed: a level of reduced glutathione (it was estimated by the content of free SH-groups in tissues), the content of thiamine diphosphate and thiaminekinase activity in a brain, the content of folic acid in the blood, the content of ubiquinone in the cardiac muscle, RNA/DNA relation in the liver. The data obtained demonstrate first of all the negative influence of alcohol on metabolism of sulfur-containing substances and processes of transmethylation. The results of our investigation have also shown that the part of metabolic changes caused by long-term usage of alcohol, can be caused by direct influence of ethanol or its metabolites on those or other enzymatic proteins or receptors, and their functions can quickly be normalized after the abolition of alcohol (NAD+ contents, alpha-ketoglutarate dehydrogenase activity and some others). More stable changes in other parts of metabolism, that were specified earlier, may be also a result of long-term alcohol consumption.
Parkhomenko
Iu M
IuM
Donchenko
G V
GV
Pilipchuk
S Iu
SIu
Stepanenko
S P
SP
Chekhovskaia
L I
LI
Klimenko
E P
EP
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009243:NAD / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D013997:Time Factors; D014815:Vitamins / Q000378:metabolism
D011506:Proteins; D013438:Sulfhydryl Compounds; D014815:Vitamins; D009243:NAD; D000431:Ethanol; D007655:Ketoglutarate Dehydrogenase Complex; D013835:Thiamine Pyrophosphate