title: Lung liquid clearance in newborn lamb: MRI methods and preliminary results.
abstract: To study the lung water clearance in vivo at the time of the birth, MR experiments were conducted on newborn lamb immediately after uterine incision deliverance. Images obtained with a fast spin echo sequence enable to quantify lung liquid each 5 minutes during 30 minutes then each 10 minutes for 1.5 hour. From the lung contours, pulmonary volume, pulmonary water, and spatial gradient of pulmonary water were studied. At 2 hours of life, the total pulmonary water content was still high and the liquid clearance was slower in the lower part of the lung. Air inflation increased the size of the distal airways and shifted liquid from the lung lumen towards the pulmonary interstitial tissue. The pulmonary water wash-out was belated and the passage to the aerial life was performed by progressive liberation of the superior pulmonary spaces, water flowing out by gravity toward the lower spaces.
authors.affiliation: INSERM U 703, France. r-viard@chru-lille.fr
authors.forename: R
authors.initials: R
authors.lastname: Viard
authors.forename: M
authors.initials: M
authors.lastname: Vermandel
authors.forename: P
authors.initials: P
authors.lastname: Tourneux
authors.forename: L
authors.initials: L
authors.lastname: Storme
authors.forename: J
authors.initials: J
authors.lastname: Rousseau
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015633:Extravascular Lung Water / Q000502:physiology*; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012756:Sheep