title: Synthesis and natural distribution of anti-inflammatory alkamides from Echinacea.
abstract: The synthesis of the alkamides 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (1) and 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (5) was accomplished by organometallic coupling followed by introduction of the doubly unsaturated amide moiety. The distribution of these two amides in accessions of the nine species of Echinacea was determined.
authors.affiliation: Iowa State University, Department of Chemistry, Ames, IA 50011, USA. gakraus@iastate.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kraus
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Bae
authors.forename: Lankun
authors.initials: L
authors.lastname: Wu
authors.forename: Eve
authors.initials: E
authors.lastname: Wurtele
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D020900:Echinacea / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051379:Mice; D053284:Polyunsaturated Alkamides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053284:Polyunsaturated Alkamides