title: Visceral hypersensitivity and intolerance symptoms in lactose malabsorption.
abstract: Lactose malabsorption is not always associated with intolerance symptoms. The factors responsible for symptom onset are not yet completely known. As differences in visceral sensitivity may play a role in the pathogenesis of functional symptoms, we evaluated whether an alteration of visceral sensitivity is present in subjects with lactose intolerance. Thirty subjects, recruited regardless of whether they were aware of their capacity to absorb lactose, underwent an evaluation of intestinal hydrogen production capacity by lactulose breath test, followed by an evaluation of lactose absorption by hydrogen breath test after lactose administration and subsequently an evaluation of recto-sigmoid sensitivity threshold during fasting and after lactulose administration, to ascertain whether fermentation modifies intestinal sensitivity. The role of differences in gastrointestinal transit was excluded by gastric emptying and mouth-to-caecum transit time by (13)C-octanoic and lactulose breath tests. Lactulose administration induced a significant reduction of discomfort threshold in subjects with lactose intolerance but not in malabsorbers without intolerance symptoms or in subjects with normal lactose absorption. Perception threshold showed no changes after lactulose administration. Severity of symptoms in intolerant subjects was significantly correlated with the reduction of discomfort thresholds. Visceral hypersensitivity should be considered in the induction of intolerance symptoms in subjects with lactose malabsorption.
authors.affiliation: Department of Medicine, IRCCS S.Matteo Hospital, University of Pavia, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Stefano
authors.forename: E
authors.initials: E
authors.lastname: Miceli
authors.forename: S
authors.initials: S
authors.lastname: Mazzocchi
authors.forename: P
authors.initials: P
authors.lastname: Tana
authors.forename: F
authors.initials: F
authors.lastname: Moroni
authors.forename: G R
authors.initials: GR
authors.lastname: Corazza
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001944:Breath Tests; D016022:Case-Control Studies; D005260:Female; D005512:Food Hypersensitivity / Q000503:physiopathology*; D005746:Gastric Emptying / Q000502:physiology; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007787:Lactose Intolerance / Q000503:physiopathology*; D007792:Lactulose / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D012720:Severity of Illness Index; D014781:Viscera / Q000503:physiopathology*
chemical_list: D005765:Gastrointestinal Agents; D007792:Lactulose