title: Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease.
abstract: The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Alvira
authors.forename: Isidre
authors.initials: I
authors.lastname: Ferrer
authors.forename: Javier
authors.initials: J
authors.lastname: Gutierrez-Cuesta
authors.forename: Beatriz
authors.initials: B
authors.lastname: Garcia-Castro
authors.forename: Merce
authors.initials: M
authors.lastname: Pallàs
authors.forename: Antoni
authors.initials: A
authors.lastname: Camins
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002154:Calpain / Q000378:metabolism*; D016022:Case-Control Studies; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; C118136:TPPP protein, human; D051360:Cyclin-Dependent Kinase 5; D002154:Calpain