title: Synthesis, chemical characterization and biological screening for cytotoxicity and antitumor activity of organotin (IV) derivatives of 3,4-methylenedioxy 6-nitrophenylpropenoic acid.
abstract: A series of mono-, di- and triorganotin compounds with general formulae [RSnL(2)Cl], R = Bu (compound 3), [R(2)SnL(2)], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R(3)SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear ((1)H-, (13)C- and (119)Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL(2)Cl] < [R(2)SnL(2)] < [R(3)SnL].
authors.affiliation: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. sheeraz_qau@yahoo.com
authors.forename: Muhammad Sheeraz
authors.initials: MS
authors.lastname: Ahmad
authors.forename: Mukhtiar
authors.initials: M
authors.lastname: Hussain
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.forename: Saqib
authors.initials: S
authors.lastname: Ali
authors.forename: Bushra
authors.initials: B
authors.lastname: Mirza
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D009578:Nitrobenzenes; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010941:Plant Tumors; D011422:Propionates / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C525001:3,4-methylenedioxy 6-nitrophenylpropenoic acid; D009574:Nitro Compounds; D009578:Nitrobenzenes; D009947:Organotin Compounds; D011422:Propionates