Identification of adenoviruses in specimens from high-risk pediatric stem cell transplant recipients and controls.
Adenovirus infection is an important cause of morbidity and mortality in stem cell transplant recipients. We report species and type-specific analysis from a prospective study of high-risk adenovirus infections following hematopoietic progenitor cell transplantation prior to, during, and after treatment with cidofovir, as well as species analysis of contemporaneously collected samples from control patients. Nine different adenovirus types representing all six recognized species were identified, and mixed infections were commonly found in this group of patients.
Zheng
Xiaotian
X
Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. x-zheng@northwestern.edu
Lu
Xiaoyan
X
Erdman
Dean D
DD
Anderson
Evan J
EJ
Guzman-Cottrill
Judith A
JA
Kletzel
Morris
M
Katz
Ben Z
BZ
D000256:Adenoviridae / Q000145:classification* / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy; D000293:Adolescent; D000818:Animals; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004279:DNA, Viral / Q000235:genetics; D005838:Genotype; D006801:Humans; D007223:Infant; D008253:Macaca mulatta; D063065:Organophosphonates / Q000627:therapeutic use; D011446:Prospective Studies; D017422:Sequence Analysis, DNA; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014180:Transplantation; D014776:Virus Cultivation
D004279:DNA, Viral; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir