[Experience of vitamin K2 in Thailand].
Vitamin K(2) has dual actions, stimulates osteoblastic functions, for synthesis of osteocalcin, osteonectin and other matrix bone proteins, in addition, new finding, in stem cell culture found osteoblast producing gene expression of collagen type 1, the other action, vitamin K(2) contains mild antiresorpion by inducing the osteoclastic apoptosis. Our study found that postmenopausal and elderly women have high risk of vitamin K(2) deficiency, comparing to the normal value of young, reproductive females. The efficacy of vitamin K(2) will be fulfill benefit after 6 months of administration, prolong use will enhance of bone quality that prevent fracture.
Bunyaratavej
Narong
N
Engineering and Tissue Growth Laboratory (CETGL) Mahidol University, Thailand.
D017209:Apoptosis / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D015675:Osteocalcin / Q000096:biosynthesis; D010010:Osteoclasts / Q000166:cytology; D024482:Vitamin K 2 / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000150:complications / Q000188:drug therapy; D000097568:Matrix Gla Protein
D002135:Calcium-Binding Proteins; D024042:Collagen Type I; D016326:Extracellular Matrix Proteins; D015675:Osteocalcin; D024482:Vitamin K 2; D000097568:Matrix Gla Protein