title: Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
abstract: Placental tissue draws great interest as a source of cells for regenerative medicine because of the phenotypic plasticity of many of the cell types isolated from this tissue. Furthermore, placenta, which is involved in maintaining fetal tolerance, contains cells that display immunomodulatory properties. These two features could prove useful for future cell therapy-based clinical applications. Placental tissue is readily available and easily procured without invasive procedures, and its use does not elicit ethical debate. Numerous reports describing stem cells from different parts of the placenta, using nearly as numerous isolation and characterization procedures, have been published. Considering the complexity of the placenta, an urgent need exists to define, as clearly as possible, the region of origin and methods of isolation of cells derived from this tissue. On March 23-24, 2007, the first international Workshop on Placenta Derived Stem Cells was held in Brescia, Italy. Most of the research published in this area focuses on mesenchymal stromal cells isolated from various parts of the placenta or epithelial cells isolated from amniotic membrane. The aim of this review is to summarize and provide the state of the art of research in this field, addressing aspects such as cell isolation protocols and characteristics of these cells, as well as providing preliminary indications of the possibilities for use of these cells in future clinical applications.
authors.affiliation: Centro di Ricerca E. Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, 25124 Brescia, Italy. ornella.parolini@tin.it
authors.forename: Ornella
authors.initials: O
authors.lastname: Parolini
authors.forename: Francesco
authors.initials: F
authors.lastname: Alviano
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Bagnara
authors.forename: Grozdana
authors.initials: G
authors.lastname: Bilic
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Bühring
authors.forename: Marco
authors.initials: M
authors.lastname: Evangelista
authors.forename: Simone
authors.initials: S
authors.lastname: Hennerbichler
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Marta
authors.initials: M
authors.lastname: Magatti
authors.forename: Ning
authors.initials: N
authors.lastname: Mao
authors.forename: Toshio
authors.initials: T
authors.lastname: Miki
authors.forename: Fabio
authors.initials: F
authors.lastname: Marongiu
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Toshio
authors.initials: T
authors.lastname: Nikaido
authors.forename: C Bettina
authors.initials: CB
authors.lastname: Portmann-Lanz
authors.forename: Venkatachalam
authors.initials: V
authors.lastname: Sankar
authors.forename: Maddalena
authors.initials: M
authors.lastname: Soncini
authors.forename: Guido
authors.initials: G
authors.lastname: Stadler
authors.forename: Daniel
authors.initials: D
authors.lastname: Surbek
authors.forename: Tsuneo A
authors.initials: TA
authors.lastname: Takahashi
authors.forename: Heinz
authors.initials: H
authors.lastname: Redl
authors.forename: Norio
authors.initials: N
authors.lastname: Sakuragawa
authors.forename: Susanne
authors.initials: S
authors.lastname: Wolbank
authors.forename: Steffen
authors.initials: S
authors.lastname: Zeisberger
authors.forename: Andreas
authors.initials: A
authors.lastname: Zisch
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Strom
mesh_terms: D000650:Amnion / Q000166:cytology / Q000276:immunology; D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D002448:Cell Adhesion; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods*; D002823:Chorion / Q000166:cytology / Q000276:immunology; D003114:Colony-Forming Units Assay; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000276:immunology / Q000637:transplantation; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology; D051379:Mice; D010920:Placenta / Q000166:cytology* / Q000276:immunology; D011247:Pregnancy; D033581:Stem Cell Transplantation; D017154:Stromal Cells / Q000166:cytology / Q000276:immunology; D014015:Tissue Banks; D014327:Trophoblasts / Q000166:cytology / Q000276:immunology
chemical_list: D000954:Antigens, Surface