title: Identification of adenoviruses in specimens from high-risk pediatric stem cell transplant recipients and controls.
abstract: Adenovirus infection is an important cause of morbidity and mortality in stem cell transplant recipients. We report species and type-specific analysis from a prospective study of high-risk adenovirus infections following hematopoietic progenitor cell transplantation prior to, during, and after treatment with cidofovir, as well as species analysis of contemporaneously collected samples from control patients. Nine different adenovirus types representing all six recognized species were identified, and mixed infections were commonly found in this group of patients.
authors.affiliation: Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. x-zheng@northwestern.edu
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Zheng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lu
authors.forename: Dean D
authors.initials: DD
authors.lastname: Erdman
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Anderson
authors.forename: Judith A
authors.initials: JA
authors.lastname: Guzman-Cottrill
authors.forename: Morris
authors.initials: M
authors.lastname: Kletzel
authors.forename: Ben Z
authors.initials: BZ
authors.lastname: Katz
mesh_terms: D000256:Adenoviridae / Q000145:classification* / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy; D000293:Adolescent; D000818:Animals; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004279:DNA, Viral / Q000235:genetics; D005838:Genotype; D006801:Humans; D007223:Infant; D008253:Macaca mulatta; D063065:Organophosphonates / Q000627:therapeutic use; D011446:Prospective Studies; D017422:Sequence Analysis, DNA; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014180:Transplantation; D014776:Virus Cultivation
chemical_list: D004279:DNA, Viral; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir