Thiophene containing triarylmethanes as antitubercular agents.
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.
Parai
Maloy Kumar
MK
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
Panda
Gautam
G
Chaturvedi
Vinita
V
Manju
Y K
YK
Sinha
Sudhir
S
D000478:Alkylation; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000995:Antitubercular Agents; D013876:Thiophenes; D014320:Triphenylmethyl Compounds; D008697:Methane