Progressive multifocal leukoencephalopathy as first manifestation of sarcoidosis.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating neurologic disorder caused by a polyomavirus, called JC virus. PML affects mainly immunocompromised hosts. We report a case of PML as first manifestation of sarcoidosis in a previously healthy man. Treatment with cidofovir, resulted in a neurological and radiological stabilization. To our knowledge the association of PML and sarcoidosis without previous immunosuppressive treatment has only been described in a few cases, none of them were treated with cidofovir.
De Raedt
Sylvie
S
Department of Neurology UZ Brussel, Brussels, Belgium. Sylvie.deraedt@uzbrussel.be
Lacor
Patrick
P
Michotte
Alex
A
Flamez
Anja
A
Ebinger
Guy
G
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir