Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes.
Because little is known about the etiology of non-Hodgkin lymphoma (NHL), a heterogeneous disease, and because dietary factors are modifiable, the authors examined the associations between nutrients related to one-carbon metabolism and risk of NHL in a population-based case-control study of Connecticut women diagnosed between 1996 and 2000. A total of 594 cases and 710 controls completed a food frequency questionnaire for determination of intakes of folate, vitamins B(2), B(6), and B(12), and methionine. Through unconditional logistic regression, the authors estimated the risk of NHL associated with intake of each nutrient. Comparing the highest quartile of intake with the lowest, the authors found lower risks of all NHL associated with increasing intakes of folate and methionine. Analysis by NHL subtype indicated lower risks of diffuse large B-cell lymphoma (highest quartile vs. lowest: odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.30, 0.98; p-trend = 0.02) and marginal zone lymphoma (highest quartile vs. lowest: OR = 0.08, 95% CI: 0.02, 0.26; p-trend < 0.0001) associated with folate. Vitamin B(6) intake was also associated with lower risk of NHL overall and of marginal zone lymphoma (highest quartile vs. lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL.
Koutros
Stella
S
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 20852, USA. koutross@mail.nih.gov
Zhang
Yawei
Y
Zhu
Yong
Y
Mayne
Susan T
ST
Zahm
Sheila Hoar
SH
Holford
Theodore R
TR
Leaderer
Brian P
BP
Boyle
Peter
P
Zheng
Tongzhang
T
D002244:Carbon / Q000378:metabolism*; D016022:Case-Control Studies; D004032:Diet; D004034:Diet Surveys; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology*; D008715:Methionine / Q000008:administration & dosage*; D008875:Middle Aged; D015999:Multivariate Analysis; D012256:Riboflavin / Q000008:administration & dosage; D012307:Risk Factors; D025101:Vitamin B 6 / Q000008:administration & dosage; D014803:Vitamin B Complex / Q000008:administration & dosage*; D014804:Vitamin B Deficiency / Q000150:complications
D014803:Vitamin B Complex; D002244:Carbon; D025101:Vitamin B 6; D005492:Folic Acid; D008715:Methionine; D012256:Riboflavin