title: Irritable bowel syndrome is more common in women regardless of the menstrual phase: a Rome II-based survey.
abstract: Functional gastrointestinal disorders are more common in women in relation to the fluctuations of female sex hormones. We tried to know the gender-related differences in the prevalence of irritable bowel syndrome and gastrointestinal symptoms according to the menstrual phase. A total of 253 women before menopause and 252 men below age 50 were examined by a gastroenterologist after completing the questionnaire. Blood tests, endoscopic procedures, and imaging studies were done, if needed. Women were subclassified into three groups according to their menstruation period; menstrual phase, proliferative phase, and secretory phase. Finally, 179 men and 193 women were analyzed. Irritable bowel syndrome was more frequently noticed in women than in men (p=0.01). The diarrhea-dominant type was more common in men, while constipation-dominant or alternating types were more common in women (p<0.001). Of 193 women, there was no significant difference in their gastrointestinal symptoms according to their menstrual phase. Regardless of the menstrual phase, gastrointestinal symptoms are more frequent in women. Physicians should consider different symptomatic manifestations between men and women should be considered when evaluating functional gastrointestinal disorders.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Sung
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Choon-Jo
authors.initials: CJ
authors.lastname: Jin
authors.forename: Won Hyeok
authors.initials: WH
authors.lastname: Choe
authors.forename: So Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Chang Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: Kyoo Wan
authors.initials: KW
authors.lastname: Choi
mesh_terms: D000328:Adult; D003967:Diarrhea / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008597:Menstrual Cycle; D008598:Menstruation; D008875:Middle Aged; D012737:Sex Factors; D011795:Surveys and Questionnaires