title: [Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia?].
abstract: Pregabalin is similar in structure to gamma-aminobutyric acid. It is used for neuropathic pain, generalized anxiety disorders and as an adjunct therapy for partial seizures. Tachycardia is a rare side-effect. A 92-year-old patient with a history of paroxystic fibrillation was hospitalised for zoster. She developed a sinusal tachycardia followed by atrial fibrillation and congestive heart failure 15 h after a first dose of pregabalin. The imputation was considered as plausible. Even though the mechanism remains unclear, pregabalin might induce tachycardia in predisposed old patients.
authors.affiliation: Centre régional de pharmacovigilance de Basse-Normandie, CHRU Côte-de-Nacre, 14033 Caen cedex, France. lavillema@yahoo.fr <lavillema@yahoo.fr>
authors.forename: M-A
authors.initials: MA
authors.lastname: Laville
authors.forename: B
authors.initials: B
authors.lastname: de la Gastine
authors.forename: B
authors.initials: B
authors.lastname: Husson
authors.forename: R
authors.initials: R
authors.lastname: Le Boisselier
authors.forename: B
authors.initials: B
authors.lastname: Mosquet
authors.forename: A
authors.initials: A
authors.lastname: Coquerel
mesh_terms: D000369:Aged, 80 and over; D000588:Amines / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000139:chemically induced*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D006333:Heart Failure / Q000139:chemically induced; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D009443:Neuritis / Q000188:drug therapy; D000069583:Pregabalin; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin