title: Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis.
abstract: OBJECTIVE
  To report a case of multiple delayed recurrence of acute retinal necrosis syndrome occurring in the same eye following initial herpetic encephalitis.
  
  
  METHODS
  Case report and review of literature.
  
  
  RESULTS
  An otherwise healthy 67-year-old woman experienced three episodes of acute retinal necrosis in the left eye 3 months, 3 years, and 12 years, respectively, following initial herpes simplex-1 encephalitis. This is the first case report of more than one such recurrence, moreover in the same eye, and with such long interval.
  
  
  CONCLUSIONS
  This case illustrates that extremely long intervals between initial herpetic encephalitis and acute necrosis syndrome recurrence can occur, thus warranting a long follow-up of these patients.
authors.affiliation: Université Libre de Bruxelles, Belgium. anna.klein@erasme.ulb.ac.be
authors.forename: Anna
authors.initials: A
authors.lastname: Klein
authors.forename: Pierre
authors.initials: P
authors.lastname: Lefebvre
mesh_terms: D000368:Aged; D020803:Encephalitis, Herpes Simplex / Q000150:complications*; D005260:Female; D005654:Fundus Oculi; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human; D006801:Humans; D012008:Recurrence; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000209:etiology* / Q000821:virology*; D013997:Time Factors