title: Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties.
abstract: Data of this study showed that alphaD-alphaE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
authors.affiliation: Laboratory of Biochemistry of Regulatory Signals, CNRS-University P&M Curie, 96 Bd Raspail, 75006, Paris, France. mounamor@yahoo.fr
authors.forename: Mouna
authors.initials: M
authors.lastname: Amor-Mahjoub
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gomez-Vrielyunck
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Suppini
authors.forename: Benoît
authors.initials: B
authors.lastname: Fouchaq
authors.forename: Nadia
authors.initials: N
authors.lastname: Benaroudj
authors.forename: Moncef
authors.initials: M
authors.lastname: Ladjimi
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D050883:HSC70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D020836:Protein Structure, Quaternary; D051381:Rats; D017384:Sequence Deletion; D014461:Ultracentrifugation
chemical_list: D050883:HSC70 Heat-Shock Proteins; C494373:Hspa8 protein, rat; D000251:Adenosine Triphosphatases