title: Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project.
abstract: OBJECTIVE
  To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study.
  
  
  METHODS
  Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
  
  
  RESULTS
  snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
  
  
  CONCLUSIONS
  Our findings suggest that snmMCI may be considered a vascular cognitive disorder.
authors.affiliation: Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: R
authors.initials: R
authors.lastname: Monastero
authors.forename: S
authors.initials: S
authors.lastname: Ercolani
authors.forename: F
authors.initials: F
authors.lastname: Mangialasche
authors.forename: M
authors.initials: M
authors.lastname: Caputo
authors.forename: F T
authors.initials: FT
authors.lastname: Feliziani
authors.forename: D F
authors.initials: DF
authors.lastname: Vitale
authors.forename: U
authors.initials: U
authors.lastname: Senin
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires