The importance of treating multiple cardiometabolic risk factors in patients with Type 2 diabetes.
Type 2 diabetes is usually associated with a number of metabolic and cardiovascular (or cardiometabolic) risk factors that contribute to a high rate of vascular events in these patients. Adipose tissue is now known to secrete a number of pro-inflammatory adipokines that are thought to mediate the link between obesity, insulin resistance and atherosclerosis. Therefore, not only is abdominal obesity a major cardiometabolic risk factor per se, it has the potential to give rise to other emerging risk factors. Plasma concentrations of inflammatory markers, such as C-reactive protein, may provide additional information to guide management and may even represent therapeutic targets. Reducing the risk of cardiovascular events in patients with Type 2 diabetes will involve targeting traditional risk factors and probably novel cardiometabolic factors.
Mikhailidis
Dimitri P
DP
Royal Free Hospital and Royal Free University College Medical School, Department of Clinical Biochemistry, Pond Street, NW3 2QG, London, UK. MIKHAILIDIS@aol.com
Press
Martin
M
D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D049628:Body Size; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000188:drug therapy; D018570:Risk Assessment; D012307:Risk Factors
D054392:Adipokines; D002097:C-Reactive Protein