Effective half life of iodine for five thyroidectomy patients using an in vivo gamma camera approach.
The effective half-life of radioactive iodine for (near) thyroidectomy patients was evaluated using an in vivo gamma camera approach. Five patients with post administered iodine for remnant ablation of thyroid were thoroughly scanned in vivo for one to four weeks. Derived data were analyzed in a MATLAB program to revise the ICRP recommended effective half-life and, thus, to offer a more reliable dose predication protocol from a health physics viewpoint. A quantitative index, AT (Agreement), was also introduced to specify the deviation between the actual measurement and the results fitted in MATLAB for each patient. The ATs were evaluated as 1.52 +/- 1.54 and 14.05 +/- 11.01 for the thyroid compartment and the remainder, re-spectively, indicating a slight discrepancy between the computed and practical results for the remainder. The actual effective half-life of iodine in the thyroid or the body fluid compartment shifted from 7.3d or 0.24 d to only 0.61 +/- 0.50 d or 0.49 +/- 0.23 d, respectively. Additionally, the integrated T(eff) for the remainder (both body fluid and whole body compartments) was still about 5.8d, since the body fluid and the whole body compartment was inseparable in real whole body scanning. The branching ratio from body fluid compartment to the thyroid and the excretion compartment also changed from 30% and 70% to 11.6 +/- 14.0% and 88.4 +/- 14.6%, respectively. The thyroid was the dominant compartment for a healthy person in the traditional biokinetic model. However, this dominant compartment was shifted to both thyroid and body fluid, based on analyses of the data following thyroidectomy, for the patients herein.
Chen
Chien-Yi
CY
Department of Medical Imaging and Radiology Science Chung Shan Medical University, Taichung, Taiwan.
Chang
Pai-Jung
PJ
Changlai
Sheng-Pin
SP
Pan
Lung-Kwang
LK
D000328:Adult; D005260:Female; D015902:Gamma Cameras; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009928:Organ Specificity; D013961:Thyroid Gland / Q000378:metabolism*; D013965:Thyroidectomy; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000295:instrumentation / Q000379:methods*
D007457:Iodine Radioisotopes