title: Evaluation and treatment of community-acquired Staphylococcus aureus infections in term and late-preterm previously healthy neonates.
abstract: OBJECTIVE
  We describe the evaluation and treatment of neonatal community-acquired Staphylococcus aureus disease in the era of community-acquired methicillin-resistant S. aureus.
  
  
  METHODS
  We retrospectively reviewed the evaluation and treatment of 126 community-acquired S. aureus infections of term and late-preterm previously healthy neonates who were < or = 30 days of age between August 2001 and July 2006 at Texas Children's Hospital.
  
  
  RESULTS
  S. aureus infections included 43 pustulosis, 68 cellulitis/abscess, and 15 invasive infections. We found 84 methicillin-resistant and 42 methicillin-susceptible S. aureus isolates. Twenty-one patients received outpatient antibiotics before hospital presentation. Systemic infection evaluation included urine, blood, and cerebrospinal fluid cultures in 79, 102, and 84 neonates, respectively. Culture revealed S. aureus urinary tract infections in 1, S. aureus bacteremias in 6, and aseptic cerebrospinal fluid pleocytosis of unclear cause in 11 neonates. Physicians admitted 106, transferred 5 to other hospitals, and discharged 15 afebrile patients with topical or oral antibiotics. Clindamycin was the predominant antistaphylococcal intravenous and oral antibiotic for pustulosis and cellulitis/abscess infections. One patient with systemic S. aureus and herpes simplex virus infection died. At discharge after inpatient treatment, physicians prescribed no antibiotics for 43 patients and oral or topical antibiotics for 62 patients. Outpatient treatment failed for 1 patient who was discharged after intravenous therapy and was readmitted. Eighty percent (16 of 20) of patients with mastitis alone completed treatment with outpatient oral antibiotics.
  
  
  CONCLUSIONS
  Evaluation and treatment strategies for neonatal community-acquired S. aureus disease are varied at our hospital. Prospective studies are needed to determine optimal management strategies.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Regine M
authors.initials: RM
authors.lastname: Fortunov
authors.forename: Kristina G
authors.initials: KG
authors.lastname: Hulten
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Hammerman
authors.forename: Edward O
authors.initials: EO
authors.lastname: Mason
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000145:classification / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D016106:Methicillin Resistance / Q000187:drug effects; D011446:Prospective Studies; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000145:classification / Q000175:diagnosis / Q000628:therapy*; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents