Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients.
Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p=<0.01) whereas higher in CSF (p=<0.01) in male>female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.
Kale
Anvita
A
Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune 411043, India.
Joshi
Sadhana
S
Naphade
Nilesh
N
Sapkale
Swati
S
Raju
M S V K
MS
Pillai
Anilkumar
A
Nasrallah
Henry
H
Mahadik
Sahebarao P
SP
D000328:Adult; D000367:Age Factors; D000553:Ambulatory Care; D016718:Arachidonic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D004032:Diet; D004281:Docosahexaenoic Acids / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D004912:Erythrocytes / Q000737:chemistry*; D005006:Ethnicity / Q000706:statistics & numerical data; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012737:Sex Factors
D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid