Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.
The dipeptidyl epoxyesters 3 and 4 are potent, irreversible inhibitors of cruzain and rhodesain.
González
Florenci V
FV
Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071 Castelló, Spain.
Izquierdo
Javier
J
Rodríguez
Santiago
S
McKerrow
James H
JH
Hansell
Elizabeth
E
D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004151:Dipeptides / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013237:Stereoisomerism; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; D004852:Epoxy Compounds; D004952:Esters; D003546:Cysteine Endopeptidases