title: Advanced biological and chemical discovery (ABCD): centralizing discovery knowledge in an inherently decentralized world.
abstract: We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization.
authors.affiliation: Information Technology, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 665 Stockton Drive, Exton, PA 19341, USA. dagrafio@prdus.jnj.com
authors.forename: Dimitris K
authors.initials: DK
authors.lastname: Agrafiotis
authors.forename: Simson
authors.initials: S
authors.lastname: Alex
authors.forename: Heng
authors.initials: H
authors.lastname: Dai
authors.forename: An
authors.initials: A
authors.lastname: Derkinderen
authors.forename: Michael
authors.initials: M
authors.lastname: Farnum
authors.forename: Peter
authors.initials: P
authors.lastname: Gates
authors.forename: Sergei
authors.initials: S
authors.lastname: Izrailev
authors.forename: Edward P
authors.initials: EP
authors.lastname: Jaeger
authors.forename: Paul
authors.initials: P
authors.lastname: Konstant
authors.forename: Albert
authors.initials: A
authors.lastname: Leung
authors.forename: Victor S
authors.initials: VS
authors.lastname: Lobanov
authors.forename: Patrick
authors.initials: P
authors.lastname: Marichal
authors.forename: Douglas
authors.initials: D
authors.lastname: Martin
authors.forename: Dmitrii N
authors.initials: DN
authors.lastname: Rassokhin
authors.forename: Maxim
authors.initials: M
authors.lastname: Shemanarev
authors.forename: Andrew
authors.initials: A
authors.lastname: Skalkin
authors.forename: John
authors.initials: J
authors.lastname: Stong
authors.forename: Tom
authors.initials: T
authors.lastname: Tabruyn
authors.forename: Marleen
authors.initials: M
authors.lastname: Vermeiren
authors.forename: Jackson
authors.initials: J
authors.lastname: Wan
authors.forename: Xiang Yang
authors.initials: XY
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Yao
mesh_terms: D001695:Biology; D019295:Computational Biology; D003201:Computers; D021621:Imaging, Three-Dimensional