title: Nano-particle labelling of nucleic acids for enhanced detection by inductively-coupled plasma mass spectrometry (ICP-MS).
abstract: Oligonucleotides containing a biotin functionality were successfully labelled with a streptavidin nanogold conjugate and subsequently separated and analysed by high performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK LE11 3TU.
authors.forename: Samantha Louise
authors.initials: SL
authors.lastname: Kerr
authors.forename: Barry
authors.initials: B
authors.lastname: Sharp
mesh_terms: D001710:Biotin / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004247:DNA / Q000032:analysis / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000032:analysis / Q000737:chemistry*; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D001710:Biotin; D006046:Gold; D004247:DNA; D019809:Streptavidin