title: [Effect of Liriope platyphylla total saponin on learning, memory and metabolites in aging mice induced by D-galactose].
abstract: OBJECTIVE
  To investigate the effects of Liriope platyphylla total saponin (LPTS) on learning, memory, neuromediators and metabolites in aging mice induced by D-galactose.
  
  
  METHODS
  Ninety Kunming mice were randomly divided into nine groups: normal saline (NS)-treated group, untreated group, high- (100 mg/kg), medium- (50 mg/kg) and low-dose (10 mg/kg) LPTS-treated groups, Shuxuening-treated group, jiaogulanosidi-treated group, flunarizine-treated group and vitamin E-treated group. The Kunming mice in the NS-treated group were administered with NS by intraperitoneal injection, while the aging mice in the other eight groups were administered with D-galactose by intraperitoneal injection. At the same time, the aging mice in different groups were fed with corresponding drugs for 42 days, and the aging items of the mice in different groups were measured, respectively.
  
  
  RESULTS
  LPTS could improve the memory of aging mice induced by D-galactose, promote its body weight, and increase the thymus and spleen indexes of the aging mice. LPTS could decrease the levels of MDA and lipofuscin, inhibit MAO activity and increase SOD activity and GSH-Px level.
  
  
  CONCLUSIONS
  LPTS may improve the ability of learning and memory and delay aging.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Bao-kang
authors.initials: BK
authors.lastname: Huang
authors.forename: Qiao-yan
authors.initials: QY
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.forename: Han-chen
authors.initials: HC
authors.lastname: Zheng
authors.forename: Lu-ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005690:Galactose; D007858:Learning / Q000187:drug effects; D031424:Liriope Plant / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D008517:Phytotherapy; D011897:Random Allocation; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D005690:Galactose