Drug effects on spermatogenesis.
Many drugs can adversely affect spermatogenesis. These effects can occur either by directly inhibiting sperm or testicular function or indirectly by impairing the hypothalamic pituitary testicular axis. In this paper, we will review the drugs that are known to adversely impact spermatogenesis, and/or sperm function and detail what is known about the mechanisms through which these compounds impair fertility in men.
Amory
John K
JK
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA. jamory@u.washington.edu
D064420:Drug-Related Side Effects and Adverse Reactions; D005298:Fertility / Q000187:drug effects; D006066:Gonads / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects