title: Toric HIFU transducer for large thermal ablation.
abstract: A new geometry of High Intensity Focused Ultrasound (HIFU) transducer is described to enlarge the coagulated volume and decrease treatments time. Eight transducer elements and their quarter-wave plate were diced out of a single toric piezocomposite element. Each transducer operates at a frequency of 3 MHz. The focal zone is conic and located at 70 mm from the transducer. A 7.5 MHz ultrasound imaging probe is placed in the centre of the device for guiding the treatment. Optimal exposure parameters were determined from numerical simulations. This new geometry allows achieving a thermal ablation of 7.5 cm3 when each of the eight transducers has performed a 5-s ultrasound exposure alternatively and consecutively. In vivo trials have been performed on five pigs to demonstrate this new principle. 33 elementary lesions have been performed. All lesions were reproducible and homogeneous. The average diameter of an elementary lesion obtained in 40 seconds was 19.5 +/- 3.8 mm (min 10 - max 29 mm). The coagulated volume obtained in 40 seconds was on average 9.1 +/- 4.6 cm3 (min 1.5 - max 17.6 cm3).
authors.affiliation: French Institute of Health and Medical Research, Lyon, F-69003, France. melodelima@lyon.inserm.fr
authors.forename: David
authors.initials: D
authors.lastname: Melodelima
authors.forename: William A
authors.initials: WA
authors.lastname: N'Djin
authors.forename: Hubert
authors.initials: H
authors.lastname: Parmentier
authors.forename: Michel
authors.initials: M
authors.lastname: Rivoire
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Chapelon
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D008099:Liver / Q000473:pathology / Q000601:surgery; D013552:Swine; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods