Five novel prenylated xanthones from Resina Garciniae.
Fourteen prenylated xanthone derivatives were isolated from gamboge, the dry latex of Garcinia hanburyi, and their structures were elucidated by a detailed spectroscopic analysis. Five of them, isogambogenic acid (1), desoxymorellinin (2), 10-methoxygambogenic acid (3), 10-methoxygambogic acid (4) and 10-ethoxy gambogic acid (5), are new compounds. All of them showed potent cytotoxicity against HL-60, SMMC-7721 and BGC-83 cells.
Feng
Feng
F
Department of Phytochemistry, China Pharmaceutical University, Nanjing, China.
Liu
Wen-Yuan
WY
Chen
You-Sheng
YS
Guo
Qing-Long
QL
You
Qi-Dong
QD
D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis / Q000379:methods; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D044004:Xanthones