title: Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia.
abstract: OBJECTIVE
  To correlate macular thickness determined by optical coherence tomography (OCT) with light increment sensitivity and visual acuity in patients with type 2 idiopathic macular telangiectasia (IMT).
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Fifty-one eyes of 30 patients with type 2 IMT were investigated. Functional assessment included best-corrected visual acuity and fundus-related microperimetry (MP1; Nidek Technologies, Padova, Italy). Retinal thickness was analyzed quantitatively by OCT3 (Carl Zeiss Meditec, Jena, Germany). The main outcome measure was the correlation of light sensitivity and visual acuity with retinal thickness.
  
  
  RESULTS
  Mean central retinal thickness was reduced compared with that of normal eyes. There was no significant correlation between central foveal thickness and foveal light sensitivity or visual acuity, respectively. Also, there was no significant correlation between mean retinal thickness temporal to the fovea and the lowest light sensitivity within that area. However, central light sensitivity in eyes with normal central foveal thickness was lower than in eyes with subnormal central foveal thickness (P = .032); this was also true for the lowest light sensitivity found temporal to the fovea (P = .025). Mean visual acuity was 20/40 and did not show significant differences in the two thickness groups.
  
  
  CONCLUSIONS
  A subnormal foveal thickness in type 2 IMT may be associated with better macular function as assessed by microperimetry. It is hypothesized that in type 2 IMT, both a primary neurosensory thinning and a low-grade macular edema can be involved. The coincidence may result in normal retinal thickness but decreased retinal function.
authors.affiliation: Department of Ophthalmology, University of Bonn, Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Charbel Issa
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Helb
authors.forename: Frank G
authors.initials: FG
authors.lastname: Holz
authors.forename: Hendrik P N
authors.initials: HP
authors.lastname: Scholl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011446:Prospective Studies; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D012171:Retinal Vessels / Q000473:pathology*; D013684:Telangiectasis / Q000175:diagnosis / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*