Get to grips: steering local actin dynamics with IQGAPs.
IQGAPs are actin-binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin-cytoskeletal dynamics by recruiting both the actin related protein (Arp)2/3 complex and/or formin-dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.
Brandt
Dominique T
DT
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Grosse
Robert
R
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D008958:Models, Molecular; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; C101203:IQ motif containing GTPase activating protein 1; D008840:Microfilament Proteins; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D020703:ras GTPase-Activating Proteins; D006160:Guanosine Triphosphate