Mucins, osmosensors in eukaryotic cells?
The molecular mechanisms required for sensing high osmolarity in the extracellular environment are not well defined in eukaryotes. A recent study showed that yeast Msb2 and Hkr1, which are related to mammalian mucins, are excellent candidates for sensing osmostress and for activating the HOG stress-activated protein kinase pathway involved in osmostress adaptation. Transmembrane mucins activate several signaling cascades in mammals and could therefore be important for sensing osmotic imbalances in higher eukaryotes.
de Nadal
Eulàlia
E
Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Spain.
Real
Francisco X
FX
Posas
Francesc
F
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000502:physiology; D020690:GTPase-Activating Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009077:Mucins / Q000378:metabolism*; D009994:Osmolar Concentration; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction
D020690:GTPase-Activating Proteins; C512735:HKR1 protein, S cerevisiae; D047908:Intracellular Signaling Peptides and Proteins; C076360:MSB2 protein, S cerevisiae; D008565:Membrane Proteins; D009077:Mucins; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases