Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.
Newsome
Jeffery J
JJ
Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK.
Colucci
Marie A
MA
Hassani
Mary
M
Beall
Howard D
HD
Moody
Christopher J
CJ
D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013379:Substrate Specificity
D001562:Benzimidazoles; D052160:Benzothiazoles; D011809:Quinones; D011994:Recombinant Proteins; C031000:benzimidazole; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; C005465:benzothiazole