[Clinical analysis of the effect of cervical conization on fertility and pregnancy outcome].
OBJECTIVE
To evaluate the effect of conization for cervical intraepithelial neoplasia on the outcome of subsequent fertility and pregnancy.


METHODS
A retrospective study was performed of patients who underwent conization from 1999 to 2005 in Peking Union Medical College Hospital. The nullipara patients below 40-years old without primary or secondary infertility were followed up.


RESULTS
Thirty-five patients aged from 23 to 40 years, who had pregnancy desire, were included in the study. The mean age of patients was 31 years. Twenty-five women with 26 pregnancies were identified among the 35 patients, and the pregnancy rate was 74% (26/35), which was not significantly different from that of the same patients before conization (69%, P > 0.05). Among the 26 pregnancies, there occurred one ectopic pregnancy and four cases of spontaneous abortion. In the 13 delivery cases, there were one premature delivery, two cases of premature rupture of the membrane, and ten cases of cesarean section. The sample height of the cone was less than 2.0 cm in the nine delivery cases, and the mean width of the cone was over 2.5 cm.


CONCLUSIONS
No evidence of secondary infertility caused by cervical conization was found. There was also no significant increase in the number of either premature delivery cases or low birth weight infants. The sample height of the cone might play a more important role in the pregnancy outcome than the width, which still needs to be further verified by larger studies.
He
Hao-jie
HJ
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Pan
Ling-ya
LY
Huang
Hui-fang
HF
Lang
Jing-he
JH
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery; D019092:Conization; D036861:Delivery, Obstetric; D005260:Female; D005298:Fertility; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*