title: Right ventricular pacing-induced electrophysiological remodeling in the human heart and its relationship to cardiac memory.
abstract: BACKGROUND
  Right ventricular apical (RVA) pacing induces electrophysiological and structural remodeling. Cardiac memory (CM) evolves during the course of pacing and is readily apparent on electrocardiography (ECG) or vectorcardiography (VCG) when normal ventricular activation resumes.
  
  
  OBJECTIVE
  This study sought to assess ventricular repolarization (VR) changes during pacing and intermittent normal ventricular conduction by ECG and VCG and to determine the temporal and conformational evolution of CM.
  
  
  METHODS
  Twenty sick sinus patients received a dual-chamber rate-adaptive (DDD-R) pacemaker and were paced from the RVA endocardium. The pacemakers were programmed to a short AV delay to maximize ventricular preexcitation. The ECG and VCG were recorded before and 1 day after implantation, and then daily for the first week (n=6) or weekly for 5 to 8 weeks (n=14), with the pacemakers temporarily programmed to AAI (normal ventricular activation).
  
  
  RESULTS
  The first parameters to change were T-vector amplitude, T(area), and T(peak)-T(end) (T(p-e)), which decreased within 1 day after initiating pacing. CM became apparent between day 1 and day 3, was fully established after 1 week, and then remained stable. Signs of increased VR heterogeneity were observed as the T loop became more circular (decreased T(egenv)) and distorted (increased T(avplan)), which have previously been observed in conditions with increased risk for arrhythmias. Over weeks, VR duration was prolonged (increased QTc). In contrast, during ventricular pacing, a gradual shortening of the repolarization time was observed, suggesting a stabilizing adaptive process.
  
  
  CONCLUSIONS
  In sick sinus syndrome patients in whom ventricular pacing is indicated, switching between normal AV conduction and ventricular pacing should be minimized to avoid periods of repolarization instability.
authors.affiliation: Department of Cardiology, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden. liliane.wecke@karolinska.se
authors.forename: Liliane
authors.initials: L
authors.lastname: Wecke
authors.forename: Aigars
authors.initials: A
authors.lastname: Rubulis
authors.forename: Gunilla
authors.initials: G
authors.lastname: Lundahl
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rosen
authors.forename: Lennart
authors.initials: L
authors.lastname: Bergfeldt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054849:Cardiac Electrophysiology; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012804:Sick Sinus Syndrome / Q000628:therapy; D016276:Ventricular Function; D020257:Ventricular Remodeling / Q000502:physiology*