title: Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
abstract: Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC=3.12-6.25microg/mL). In addition, all active compounds, 45-47, 73, and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents.
authors.affiliation: Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia. kouznet@uis.edu.co
authors.forename: Vladímir V
authors.initials: VV
authors.lastname: Kouznetsov
authors.forename: Leonor Y
authors.initials: LY
authors.lastname: Vargas Méndez
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Sortino
authors.forename: Yelkaira
authors.initials: Y
authors.lastname: Vásquez
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Mónica
authors.initials: M
authors.lastname: Freile
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Enriz
authors.forename: Susana A
authors.initials: SA
authors.lastname: Zacchino
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007097:Imines / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D054547:National Cancer Institute (U.S.); D014481:United States
chemical_list: D000814:Aniline Compounds; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007097:Imines