Bone-marrow-derived stem cells--our key to longevity?
Bone marrow (BM) was for many years primarily regarded as the source of hematopoietic stem cells. In this review we discuss current views of the BM stem cell compartment and present data showing that BM contains not only hematopoietic but also heterogeneous non-hematopoietic stem cells. It is likely that similar or overlapping populations of primitive non-hematopoietic stem cells in BM were detected by different investigators using different experimental strategies and hence were assigned different names (e.g., mesenchymal stem cells, multipotent adult progenitor cells, or marrow-isolated adult multilineage inducible cells). However, the search still continues for true pluripotent stem cells in adult BM, which would fulfill the required criteria (e.g. complementation of blastocyst development). Recently our group has identified in BM a population of very small embryonic-like stem cells (VSELs), which express several markers characteristic for pluripotent stem cells and are found during early embryogenesis in the epiblast of the cylinder-stage embryo.
Ratajczak
Mariusz Z
MZ
Stem Cell Institute, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA. mzrata01@louisville.edu
Zuba-Surma
Ewa K
EK
Machalinski
Boguslaw
B
Kucia
Magdalena
M
D001854:Bone Marrow Cells / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008136:Longevity; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D039901:Totipotent Stem Cells / Q000502:physiology