Successful treatment of recurrent Henoch-Schönlein purpura in a renal allograft with plasmapheresis.
Acute and severe cases of Henoch-Schönlein purpura (HSP) nephritis have been treated with plasmapheresis (PA) in both adults and children. It has been used either alone or with steroids, antiplatelets or cytoxic drugs. Generally, renal function has been shown to improve when PA is utilized. The role of PA in recurrent HSP after renal transplantation is unclear and has not been well described in the literature. We report a 29-year-old female with HSP who developed end-stage renal disease and subsequently underwent a renal transplantation with eventual loss of the allograft 5 years later due to recurrent HSP nephritis. Retransplantion was performed and the patient developed active HSP nephritis in her second allograft within a week after transplantation. In an effort to preserve her allograft, four cycles of PA were performed. Her proteinuria resolved and renal biopsies afterwards demonstrated marked reduction in mesangial IgA deposition. We conclude that PA may be useful in recurrent HSP nephritis, especially when used early. The risk of additional immunosuppression caused by PA needs to be considered. More studies need to be done to evaluate the efficacy of PA in this setting as well as to define the optimal treatment regimen.
Lee
J
J
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. Jennifer.Lee@hsc.utah.edu
Clayton
F
F
Shihab
F
F
Goldfarb-Rumyantzev
A
A
D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000517:prevention & control / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery* / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects*; D009393:Nephritis / Q000209:etiology / Q000601:surgery / Q000628:therapy; D010956:Plasmapheresis; D055502:Secondary Prevention; D014184:Transplantation, Homologous