title: Effects of diets supplemented with organic acids and nucleotides on growth, immune responses and digestive tract development in weaned pigs.
abstract: Sixty-eight (Experiment 1, 46 days feeding) and sixteen (Experiment 2, 21 days feeding) 21-days-old weaned pigs were allotted to four dietary treatments including control, 0.6% organic acids (OA), 0.1% nucleotides (NA) and 0.6% OA plus 0.1% NA for determining the dietary effects. In Experiment 1, OA enhanced peripheral blood mononuclear cells proliferation on day 28 and 46. The plasma immunoglobulin (Ig) A level was elevated by OA (p < 0.06) and NA (p < 0.07), respectively. In Experiment 2, NA increased plasma IgM level, and had an interactive effect with OA on ileal Peyer's patches and mesenteric lymph node lymphocyte proliferation, bile and plasma IgA levels, and jejunal crypt depth. NA elevated gastric pepsin and jejunal alkaline phosphatase activities, however, decreased ileal aminopeptidase N, sucrase or maltase activity. These results suggest that OA and NA have synergistically enhanced the gut-associated lymphocyte responses and NA modulates the digestive tract development of weaned pigs.
authors.affiliation: Department of Animal Science, National Ilan University, Ilan, Taiwan.
authors.forename: D N
authors.initials: DN
authors.lastname: Lee
authors.forename: S R
authors.initials: SR
authors.lastname: Liu
authors.forename: Y T
authors.initials: YT
authors.lastname: Chen
authors.forename: R C
authors.initials: RC
authors.lastname: Wang
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.forename: C F
authors.initials: CF
authors.lastname: Weng
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena / Q000276:immunology / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D019587:Dietary Supplements; D004357:Drug Synergism; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000254:growth & development*; D007070:Immunoglobulin A / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D009711:Nucleotides / Q000494:pharmacology*; D009930:Organic Chemicals / Q000494:pharmacology*; D010581:Peyer's Patches / Q000166:cytology / Q000254:growth & development; D011897:Random Allocation; D013154:Spleen / Q000166:cytology / Q000254:growth & development; D013552:Swine / Q000254:growth & development* / Q000276:immunology*; D014886:Weaning; D015430:Weight Gain
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M; D009711:Nucleotides; D009930:Organic Chemicals