title: Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity.
abstract: The aerial parts of Centaurea pullata afforded, in addition to the previously isolated sesquiterpene lactones, 11beta,13-dihydrocnicin and 11beta,13-dihydro-19-desoxycnicin, three minor sesquiterpene lactones, namely, a new germacranolide, 8alpha-O-(4-acetoxy-5-hydroxyangeloyl)-11beta,13-dihydrocnicin, and two new eudesmanolides, 8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydrosonchucarpolide and 8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydro-4-epi-sonchucarpolide. The in vitro antimicrobial activity of all isolated sesquiterpene lactones was tested against six bacteria and eight fungal species, using a microdilution method. All compounds tested showed greater antibacterial and antifungal activities than the positive controls used.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece.
authors.forename: Samah
authors.initials: S
authors.lastname: Djeddi
authors.forename: Anastasia
authors.initials: A
authors.lastname: Karioti
authors.forename: Marina
authors.initials: M
authors.lastname: Sokovic
authors.forename: Dejan
authors.initials: D
authors.lastname: Stojkovic
authors.forename: Ratiba
authors.initials: R
authors.lastname: Seridi
authors.forename: Helen
authors.initials: H
authors.lastname: Skaltsa
mesh_terms: D000462:Algeria; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D031179:Centaurea / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C525341:8alpha-O-(4-acetoxy-5-hydroxyangeloyl)-11beta,13-dihydrocnicin; C525343:8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydro-4-epi-sonchucarpolide; C525342:8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydrosonchucarpolide; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007783:Lactones; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane