The dynamics of cancer chromosomes and genomes.
A key feature of cancer chromosomes and genomes is their high level of dynamics and the ability to constantly evolve. This unique characteristic forms the basis of genetic heterogeneity necessary for cancer formation, which presents major obstacles to current cancer diagnosis and treatment. It has been difficult to integrate such dynamics into traditional models of cancer progression. In this conceptual piece, we briefly discuss some of the recent exciting progress in the field of cancer genomics and genome research. In particular, a re-evaluation of the previously disregarded non-clonal chromosome aberrations (NCCAs) is reviewed, coupled with the progress of the detection of sub-chromosomal aberrations with array technologies. Clearly, the high level of genetic heterogeneity is directly caused by genome instability that is mediated by stochastic genomic changes, and genome variations defined by chromosome aberrations are the driving force of cancer progression. In addition to listing various types of non-recurrent chromosomal aberrations, we discuss the likely mechanism underlying cancer chromosome dynamics. Finally, we call for further examination of the features of dynamic genome diseases including cancer in the context of systems biology and the need to integrate this new knowledge into basic research and clinical applications. This genome centric concept will have a profound impact on the future of biological and medical research.
Ye
C J
CJ
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
Liu
G
G
Bremer
S W
SW
Heng
H H Q
HH
D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D007621:Karyotyping; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology