Quantitative analysis method to evaluate optical clearing effect of skin using a hyperosmotic chemical agent.
Light penetration depth in highly scattering tissues can be increased by using hyperosmotic chemical agents such as glycerol, PEG (polyethylene glycol) and glucose. Previous many studies used OCT, spectrometer, integrating method to quantitatively evaluate the optical clearing effect of skin. In this study, we show the optical clearing effect of skin using glycerol and suggest a new quantitative analysis method to evaluate the spatial optical clearing effect of skin using glycerol.
Yoon
Jinhee
J
Department of Biomedical Engineering, Yonsei University, South Korea. no-fate@yonsei.ac.kr
Son
Taeyoon
T
Jung
Byungjo
B
D000465:Algorithms; D000818:Animals; D046169:Dermoscopy / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D013552:Swine; D014882:Water-Electrolyte Balance / Q000187:drug effects
D017319:Photosensitizing Agents