Novel Brønsted acid catalyzed three-component alkylations of indoles with N-phenylselenophthalimide and styrenes.
Novel and efficient Brønsted acid (p-TsOH) catalyzed inter- and intramolecular Friedel-Crafts alkylations have been developed to synthesize selenated three-component coupling and selenation-cyclization indole derivatives. Chemical removal of the phenylseleno moiety was investigated, and the reaction mechanisms were discussed.
Zhao
Xiaodan
X
Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian, Liaoning 116023, PR China.
Yu
Zhengkun
Z
Xu
Tongyu
T
Wu
Ping
P
Yu
Haifeng
H
D000143:Acids / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010797:Phthalimides / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry*
D000143:Acids; D007211:Indoles; D010636:Phenols; D010797:Phthalimides; D018036:Selenium Compounds; D013343:Styrenes; C030374:indole