Total syntheses of carbohydrates: organocatalyzed aldol additions of dihydroxyacetone.
The selective total synthesis of carbohydrates with defined configuration has been of great interest for a long time. This field has been the domain of enzymatic methods so far. But now the recent development of several organocatalyzed aldol methodologies has made a selective synthetic approach to configuratively defined carbohydrates possible. This development and different strategies will be discussed in this concept article.
Markert
Morris
M
Institut für Chemie, Humbold-Universität, 12489 Berlin, Brook-Taylor Strasse 2, Germany.
Mahrwald
Rainer
R
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004987:Ethers / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry; D013912:Threonine / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D002241:Carbohydrates; D004987:Ethers; D013912:Threonine; C014634:lactaldehyde; C116609:3-hydroxybutanal; D011392:Proline