title: Body composition and selected blood parameters in mice fed a combination of fibre and conjugated linoleic acid.
abstract: Feeding mice conjugated linoleic acid (CLA) reduces body fat. Soluble fibre decreases apparent lipid digestibility. The objective of the present study was to examine whether a combination of dietary CLA and soluble fibre would further decrease the proportion of body fat than a diet with CLA alone. Therefore, we fed mice diets with CLA and different amounts of Nutrim, containing 10% soluble fibre. CLA was added to the control diet at the expense of high oleic acid sunflower oil (HOSF) component and Nutrim was added at the expense of an isoenergetic combination of starch, dextrose and cellulose. The diets were fed for 28 days. Weight gain after 28 days was less in CLA-fed animals than in HOSF-fed animals. Both CLA and Nutrim increased the body water content. CLA reduced total body fat and epidydymal fat but Nutrim did not. No interaction of CLA and fibre was detected. We, therefore, must conclude that under the present experimental conditions dietary CLA and fibre do not interact to reduce body fat deposition.
authors.affiliation: Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Javadi
authors.forename: M J H
authors.initials: MJ
authors.lastname: Geelen
authors.forename: H
authors.initials: H
authors.lastname: Everts
authors.forename: A G
authors.initials: AG
authors.lastname: Lemmens
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004063:Digestion; D004305:Dose-Response Relationship, Drug; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D012995:Solubility; D015430:Weight Gain
chemical_list: D004042:Dietary Fats, Unsaturated; D004043:Dietary Fiber; D044243:Linoleic Acids, Conjugated