title: Differences in fetal growth, discordancy, and placental pathology in reduced versus nonreduced twins.
abstract: This study evaluated the effect of multifetal pregnancy reduction on the incidence of small for gestational age (SGA) and discordance in reduced versus nonreduced twins and differences in placental pathology. A computerized ultrasound database was used to identify diamniotic-dichorionic twins who delivered at our institution. Reduced (n = 36) versus nonreduced twins (n = 243) were compared for differences in rates of SGA and discordancy (>or= 20%.) The groups were compared for differences in maternal and neonatal characteristics, as well as differences in placental pathology. Chi-square tests were used to compare differences in means. Stepwise logistic regression was used to adjust for potential confounders including placental pathology. The rate of SGA in either twin A or B remained nonsignificant after adjustment for the use of assisted reproductive technology and gestational age at delivery in the stepwise logistic model (odds ratio, 1.7 95%; confidence interval, 0.5, 5.2). The average discordance at delivery was 12.4% in reduced versus 11.4% in the nonreduced twins ( P = 0.54). We found no overall differences in placental pathology between the two groups. Reduced and nonreduced twins have no significant differences in SGA fetuses, growth discordancy, or placental pathology.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Medical Center, New York, New York 10029-6574, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Belogolovkin
authors.forename: Lauren
authors.initials: L
authors.lastname: Ferrara
authors.forename: Erin
authors.initials: E
authors.lastname: Moshier
authors.forename: Manisha
authors.initials: M
authors.lastname: Gandhi
authors.forename: Keith
authors.initials: K
authors.lastname: Eddleman
authors.forename: Joanne
authors.initials: J
authors.lastname: Stone
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D047109:Fetal Development; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal; D011272:Pregnancy, Multiple; D014427:Twins; D016216:Ultrasonography, Prenatal