[Clindamycin is unsuitable for the empirical treatment of infections due to pig-related methicillin-resistant Staphylococcus aureus (MRSA)].
OBJECTIVE
To determine the antibiotic sensitivity of methicillin-resistant Staphylococcus aureus (MRSA) isolated from persons in contact with pigs.


METHODS
Retrospective.


METHODS
The pig-related MRSA collection, built up between January 1st 2003 and November 30th 2006 in the Regional Laboratory for Medical Microbiology and Infection Prevention (RLMMI) of the Jeroen Bosch Hospital, Den Bosch, The Netherlands, was tested for sensitivity to a large number ofantibiotics.


RESULTS
A total of 65 isolates were obtained from 53 patients. All (100%) of the pig-related MRSA isolates were sensitive to vancomycin, teicoplanin, nitrofurantoin, rifampicin, linezolid, and quinupristin-dalfopristin. Variable sensitivity was found for erythromycin (40%), clindamycin (48%), cotrimoxazole (48%), aminoglycosides (92%), tetracycline (6%), and quinolones (94%).


CONCLUSIONS
In view of the sensitivities found, clindamycin does not seem suitable for the empirical therapy ofpig-related MRSA-infections. In case of severe infection, therapy should be started either with an intravenous glycopeptide or with oral ciprofloxacin, possibly combined with rifampicin or linezolid.
Renders
N H M
NH
Jeroen Bosch Ziekenhuis, afd. Regionaal Laboratorium Medische Microbiologie en Infectiepreventie, Tolbrugstraat 11, 5200 ME's-Hertogenbosch. n.renders@jbz.nl
Janssen
M H W
MH
Leenders
A C A P
AC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000635:transmission / Q000662:veterinary; D013211:Staphylococcus aureus / Q000187:drug effects*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000635:transmission; D016896:Treatment Outcome; D015047:Zoonoses
D000900:Anti-Bacterial Agents; D002981:Clindamycin