title: Synthesis, characterization, antifungal and anti-HIV activities of metal(II) complexes of 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol.
abstract: Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements. According to the data obtained the organic compound acts as a bidentate O,S-coordinated ligand and yields Co(II) and Ni(II) complexes of the stoichiometry ML(2) which is characterized by square planar geometry. Antifungal and anti-HIV activities of the ligand and its metal(II) complexes were found to decrease in the sequence CuL(2)>CoL(2) ~ NiL(2)>HL, along with their reducing ability (determined electrochemically).
authors.affiliation: Faculty of Chemistry, Belarusian State University, Minsk, Belarus. loginonv@yahoo.com
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Loginova
authors.forename: Tat'yana V
authors.initials: TV
authors.lastname: Koval'chuk
authors.forename: Genrikh I
authors.initials: GI
authors.lastname: Polozov
authors.forename: Nikolai P
authors.initials: NP
authors.lastname: Osipovich
authors.forename: Pyotr G
authors.initials: PG
authors.lastname: Rytik
authors.forename: Igor I
authors.initials: II
authors.lastname: Kucherov
authors.forename: Anna A
authors.initials: AA
authors.lastname: Chernyavskaya
authors.forename: Victor L
authors.initials: VL
authors.lastname: Sorokin
authors.forename: Oleg I
authors.initials: OI
authors.lastname: Shadyro
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D008670:Metals / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: C532283:4,6-di-tert-butyl-3-((2-hydroxyethyl)thio)benzene-1,2-diol-copper(II); D019380:Anti-HIV Agents; D000935:Antifungal Agents; D008670:Metals; D009942:Organometallic Compounds