Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.
The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo. Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE-antigen complex, with IC(50) values of 45 and 55 muM, respectively, but also inhibited the protein expressions of IL-4 and TNF-alpha. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases.
Han
Sang Jun
SJ
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun-Ku, Seoul, Korea.
Bae
Eun-Ah
EA
Trinh
Hien Trung
HT
Yang
Jung-Hwa
JH
Youn
Ui-Jung
UJ
Bae
Ki-Hwan
KH
Kim
Dong-Hyun
DH
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E / Q000276:immunology; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology; D000498:Allyl Compounds; D010636:Phenols
D018926:Anti-Allergic Agents; D001713:Biphenyl Compounds; D007073:Immunoglobulin E; D017705:Lignans; D001619:beta-N-Acetylhexosaminidases; D003189:p-Methoxy-N-methylphenethylamine; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols