A new fatty ester and a new triterpene from Skimmia laureola.
Aerial parts of Skimmia laureola yielded a new fatty ester, (+)-skimmilaureol (1), and a new triterpene 16-29-dihydroxy, 20-ene cyclolaudenol (2). Five known compounds, namely, O-methyl-cyclolaudenol (3), (R)-7-methoxy-6-(3'-hydroxy-2'R-methoxy-3'-methyl butyl)coumarin (4), (+)-(S)-psi-ribalinine (5), (R)-(+)-ribalinine (6) and methyl isoplatydesmine (7), previously isolated from this plant were subjected to enzymatic bioassays for the first time. Compounds 3 and 4 were found to be prolyl endopeptidase inhibitors with IC(50) 8.21 +/- 0.407 and 39.63 +/- 1.502 microM, respectively, while compounds 5-7 were found to be acetyl-cholinesterase and butyryl-cholinesterase inhibitors with IC(50) 62.46 +/- 1.58, 153.31 +/- 1.9, 74.5 +/- 1.05 and 150.04 +/- 0.45, 12.99 +/- 0.31, 78.3 +/- 1.86 microM, respectively.
Sultana
Nighat
N
Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi, Pakistan. nighat2001us@yahoo.com
Khalid
Asaad
A
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D015394:Molecular Structure; D010154:Pakistan; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C528267:16-29-dihydroxy, 20-ene cyclolaudenol; D002800:Cholinesterase Inhibitors; D004952:Esters; D005231:Fatty Acids, Unsaturated; D010840:Phytosterols; D014315:Triterpenes; C528266:skimmilaureol; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase