Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area.
The cholinergic neurons in the laterodorsal tegmental nucleus (LDT) play a crucial role in the regulation of rapid eye movement (REM) sleep. Because penile erection occurs during REM sleep, the involvement of the LDT in penile erection was examined in unanesthetized head-restrained rats. To detect penile erection, corpus spongiosum of the penis (CSP) pressure was measured through a telemetric device with simultaneous bulbospongiosum (BS) muscle EMG recording through stainless wires. Electrical stimulation in and around the LDT induced the following three CSP pressure patterns: 1) a full erection pattern indistinguishable from the nonevoked or spontaneous erection, characterized by a slow increase in CSP pressure with additional sharp CSP peaks associated with BS muscle bursts, 2) a muscular pattern characterized by sharp CSP pressure peaks but in the absence of a vascular component, i.e., without an increase in baseline CSP pressure, and 3) a mixed-type response characterized by high-frequency CSP pressure peaks followed by a full erection response. Full erections were evoked in and around the LDT, including more medially and ventrally. The sites for inducing mixed-type events were intermingled with the sites that triggered full erections in the anterior half of the LDT, whereas they were separated in the posterior half. The sites for muscular responses were lateral to the sites for full erections. Finally, a CSP pressure response identical to micturition was evoked in and around the Barrington's nucleus and in the dorsal raphe nucleus. These results suggest that the LDT and surrounding region are involved in the regulation of penile erection. Moreover, different anatomical areas in the mesopontine tegmentum may have specific roles in the regulation of penile erection and micturition.
Salas
Juan Carlos Toledo
JC
Department of Physiology, Fukushima Medical University, Fukushima, Japan.
Iwasaki
Hiroshi
H
Jodo
Eiichi
E
Schmidt
Markus H
MH
Kawauchi
Akihiro
A
Miki
Tsuneharu
T
Kayama
Yukihiko
Y
Otsuki
Manabu
M
Koyama
Yoshimasa
Y
D000818:Animals; D001933:Brain Stem / Q000502:physiology; D004558:Electric Stimulation; D004576:Electromyography; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D010410:Penile Erection / Q000502:physiology*; D011149:Pons / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014554:Urination / Q000502:physiology*; D017557:Ventral Tegmental Area / Q000502:physiology*