title: Multicystic adenomatoid hamartoma of the pancreas: a hitherto undescribed pancreatic tumor occurring in a 3-year-old boy.
abstract: This report describes an unusual pancreatic tumor in a 3-year-old boy. He presented with abdominal pain secondary to pancreatitis and was found to have a complex, multicystic lesion within the head of the pancreas. He subsequently underwent a pancreatoduodenectomy. Grossly, the mass was 3 cm, multicystic, and well demarcated. Histologically, there were numerous variably sized, dilated ducts lined by tall columnar mucinous cells surrounded by a stroma that exhibited foci of cellular condensations resembling primitive pancreatic mesenchyme. Acinar and endocrine cells were often seen budding into the ducts forming "ductulo-insular bodies." As a result of its superficial resemblance to Stocker type 2 cystic adenomatoid malformation of the lung, we are proposing the name "multicystic adenomatoid hamartoma" for this lesion.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Thrall
authors.forename: Jose
authors.initials: J
authors.lastname: Jessurun
authors.forename: Edward B
authors.initials: EB
authors.lastname: Stelow
authors.forename: N Volkan
authors.initials: NV
authors.lastname: Adsay
authors.forename: Selwyn M
authors.initials: SM
authors.lastname: Vickers
authors.forename: Amy K
authors.initials: AK
authors.lastname: Whitson
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Saltzman
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation; D002675:Child, Preschool; D018572:Disease-Free Survival; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D053552:Keratin-7 / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010182:Pancreatic Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy
chemical_list: D015415:Biomarkers; D053552:Keratin-7