title: From bench-top small animal diffuse optical tomography towards clinical imaging.
abstract: Fluorescence enhanced diffuse optical tomography is an emergent diagnosis tool for the localization and the quantification of fluorescent probes; this technique comes as a supplement or sometimes replaces the classical ionizing radiation imaging techniques, and in particular if a simple, inexpensive, non invasive and accurate instrumentation is sought. For 4 years now, the CEA-LETI has built a base of knowledge in markers and instrumentation within the framework of small animal imaging. More recently, an instrumentation has been developed, the purpose of which is a specific approach to the examination of underlying structures, deeply embedded within the tissues, and in fine for human being screening.
authors.affiliation: CEA-LETI MINATEC, 17 rue des Martyrs, Grenoble Cedex 9, France. anabela.dasilva@cea.fr
authors.forename: Anabela
authors.initials: A
authors.lastname: Da Silva
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.forename: Philippe
authors.initials: P
authors.lastname: Rizo
mesh_terms: D000818:Animals; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*; D014183:Transplantation, Heterologous
chemical_list: D005456:Fluorescent Dyes