Is energy deficiency good in moderation?
In this issue, Pospisilik et al. (2007) demonstrate that a reduction in mitochondrial oxidative phosphorylation protects mice against obesity and diabetes. This finding suggests that the moderate deficiency in oxidative phosphorylation that is observed in peripheral tissues of insulin-resistant humans is not a causative factor in diabetes but may instead be a compensatory response.
Freyer
Christoph
C
Department of Laboratory Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
Larsson
Nils-Göran
NG
D000818:Animals; D051033:Apoptosis Inducing Factor / Q000172:deficiency; D003920:Diabetes Mellitus / Q000517:prevention & control; D007333:Insulin Resistance; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009765:Obesity / Q000517:prevention & control; D009928:Organ Specificity / Q000187:drug effects; D010085:Oxidative Phosphorylation
D051033:Apoptosis Inducing Factor