title: Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers.
abstract: Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view. Fatalities associated with diphenoxylate-atropine have been reported in toddlers after repetitive or incorrect dosages. Fortunately, trends in pediatric diphenoxylate-atropine ingestions are decreasing. We review the management, trends, and current concepts regarding pediatric diphenoxylate-atropine ingestions.
authors.affiliation: Department of Emergency Medicine, George Washington University, Washington, DC, USA.
authors.forename: Tenny J
authors.initials: TJ
authors.lastname: Thomas
authors.forename: Denis
authors.initials: D
authors.lastname: Pauze
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Love
mesh_terms: D001285:Atropine / Q000008:administration & dosage / Q000506:poisoning*; D002675:Child, Preschool; D004157:Diphenoxylate / Q000008:administration & dosage / Q000506:poisoning*; D004338:Drug Combinations; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007223:Infant; D008297:Male; D011041:Poisoning / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D014481:United States / Q000453:epidemiology
chemical_list: D004338:Drug Combinations; D005765:Gastrointestinal Agents; C002534:atropine sulfate-diphenoxylate hydrochloride drug combination; D004157:Diphenoxylate; D001285:Atropine