Stereoselective synthesis of macrolide-type antibiotics from epoxy amides. Synthesis of the polypropionate chain of streptovaricin u.
The synthesis of the polypropionate chain of Streptovaricin U (1) is described utilizing a new approach for the stereoselective synthesis of the macrolide-type antibiotics via sulfur ylides.
Sarabia
Francisco
F
Department of Biochemistry, Molecular Biology and Organic Chemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain. frsarabia@uma.es
Sánchez-Ruiz
Antonio
A
Martín-Ortiz
Laura
L
García-Castro
Miguel
M
Chammaa
Samy
S
D000577:Amides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000577:Amides; D000900:Anti-Bacterial Agents; D004852:Epoxy Compounds; D018942:Macrolides; D011422:Propionates; C525797:streptovaricin U