title: Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients.
abstract: OBJECTIVE
  We assessed the efficacy and safety of the application of autologous fibroblasts and myoblasts for treatment in post-prostatectomy urinary incontinence after a minimal followup of 1 year.
  
  
  METHODS
  Sixty-three patients with stress urinary incontinence after radical prostatectomy were treated with transurethral ultrasound guided injections of autologous fibroblasts and myoblasts obtained from skeletal muscle biopsies. All subjects were evaluated preoperatively and 12 months postoperatively in terms of incontinence and Quality of Life Instrument scores, urodynamic parameters, and morphology and function of the urethra and rhabdosphincter.
  
  
  RESULTS
  Of the 63 patients 41 were continent 12 months after implantation of cells, 17 showed improvement and 5 did not show any improvement. Incontinence and Quality of Life Instrument scores as well as thickness and contractility of the rhabdosphincter were significantly improved postoperatively.
  
  
  CONCLUSIONS
  The use of myoblast and fibroblast therapy represents a minimally invasive, safe and effective treatment for post-prostatectomy incontinence after a followup of 1 year.
authors.affiliation: Department of Urology, Innsbruck Medical University, Innsbruck, Austria. michael.mitterberger@i-med.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Mitterberger
authors.forename: Rainer
authors.initials: R
authors.lastname: Marksteiner
authors.forename: Eva
authors.initials: E
authors.lastname: Margreiter
authors.forename: Germar M
authors.initials: GM
authors.lastname: Pinggera
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Frauscher
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
authors.forename: Martin
authors.initials: M
authors.lastname: Fussenegger
authors.forename: Georg
authors.initials: G
authors.lastname: Bartsch
authors.forename: Hannes
authors.initials: H
authors.lastname: Strasser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005347:Fibroblasts / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008875:Middle Aged; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D011468:Prostatectomy / Q000009:adverse effects*; D013997:Time Factors; D014463:Ultrasonography; D014549:Urinary Incontinence / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*