title: Cognitive profiles of mild cognitive impairment with and without vascular disease.
abstract: This study examined whether the cognitive profile of subjects with mild cognitive impairment (MCI) with vascular disease differs from that of MCI subjects with no vascular disease. Consecutive MCI subjects with vascular disease (n=60) and matched MCI subjects with no vascular disease (n=60) were included in the study and were compared with healthy control subjects (n=60). The neuropsychological assessment comprised tests of speed and attention, episodic memory, visuospatial function, language, and executive function. Control subjects performed significantly better than did both MCI groups on the neuropsychological battery. MCI subjects with no vascular disease performed better overall than did MCI subjects with vascular disease, most clearly on tests of speed and attention, visuospatial function, and executive function. MCI subjects with and without vascular disease exhibited differences, both in terms of overall performance and of cognitive profiles. These differences can be largely explained by deficits in speed and attention and in executive function of the MCI subjects with vascular disease.
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Sweden. arto.nordlund@neuro.gu.se
authors.forename: Arto
authors.initials: A
authors.lastname: Nordlund
authors.forename: Sindre
authors.initials: S
authors.lastname: Rolstad
authors.forename: Ola
authors.initials: O
authors.lastname: Klang
authors.forename: Karin
authors.initials: K
authors.lastname: Lind
authors.forename: Stefan
authors.initials: S
authors.lastname: Hansen
authors.forename: Anders
authors.initials: A
authors.lastname: Wallin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D014652:Vascular Diseases / Q000150:complications* / Q000175:diagnosis