title: [Genetic susceptibility to Andes Hantavirus: Association between severity of disease and HLA alíeles in Chilean patients].
abstract: Andes hantavirus (ANDV) infection in Chile has a variable clinical expression, and infected individuals may present with different grades of disease severity. This study aimed to determine if clinical expression of ANDV infection in Chilean patients is associated with the HLA system. HLA alíeles A, B, DRB1 and DQB1, were studied in two groups of patients with confirmed ANDV infection: 41 patients with a mild disease course (without respiratory failure and cardiovascular shock) and 46 patients with a severe disease course (with respiratory failure and shock). Molecular typing of HLA system was performed by SSP-PCR. The HLA-DRB 1*15 alíele, was significantly more common in the group of patients with mild disease (p = 0,007) and thus for possibly associated with a protective effect against ANDV infection. Conversely, HLA-B*08 was more common in patients with severe disease (p = 0,06). Although the association was marginally significant, alíele HLA-B*08 may be linked to an increased susceptibility to the severe clinical course of HCPS by ANDV.
authors.affiliation: Programa de Genética Humana, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Ferrer C
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Vial C
authors.forename: Marcela
authors.initials: M
authors.lastname: Ferrés G
authors.forename: Paula
authors.initials: P
authors.lastname: Godoy M
authors.forename: Analla
authors.initials: A
authors.lastname: Culza V
authors.forename: Claudia
authors.initials: C
authors.lastname: Marco C
authors.forename: Constanza
authors.initials: C
authors.lastname: Castillo H
authors.forename: María Elena
authors.initials: ME
authors.lastname: Umaña C
authors.forename: Francisco
authors.initials: F
authors.lastname: Rothhammer E
authors.forename: Elena
authors.initials: E
authors.lastname: Llop R
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002677:Chile; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D018778:Hantavirus Infections / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens