[Intraarterial perfusion of inoperable adrenocortical carcinoma with emulsion of lipiodol and cytostatics in a patient with Cushing syndrome].
The therapy of adrenocortical carcinoma has not yet been standardized, and a palliative treatment with embolization of hormonally active metastases or adrenocortical tumour, could be a method of choice. We report on a case of adrenocortical carcinoma which was diagnosed as S. Cushing. In the time of diagnosis the tumour was unresectable, and the therapy with mitotane and aminoglutethimide began. When medical treatment was unsuccessful, and side effects aggravated the disease, embolization of the tumour was performed. Superselective angiography of the artery adrenalis mediae sinistrae allowed parfusion of the malignant tissue by emulsion of Streptozotocin (2 g), 5-fluorouracil (17.5 ml) and Lipiodol (15 ccm). There was no adverse reaction after this administration. Plasma cortisol levels were on the same levels three months after this therapy, and improvement of the disease was evident.
Cirić
J
J
Radojković
S
S
Drezgić
M
M
Zarković
M
M
Nesović
M
M
D018268:Adrenocortical Carcinoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D000328:Adult; D000616:Aminoglutethimide / Q000008:administration & dosage*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic; D003480:Cushing Syndrome / Q000150:complications*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008297:Male; D008939:Mitotane / Q000008:administration & dosage*; D010166:Palliative Care
D018931:Antineoplastic Agents, Hormonal; D000616:Aminoglutethimide; D008939:Mitotane; D007459:Iodized Oil