title: Successful allogeneic stem cells transplantation in severe aplastic anaemia complicated by dengue Fever.
abstract: Aplastic anaemia is characterized by severe compromise of haematopoiesis and hypocellular bone marrow. Haemorrhagic episodes in patients with aplastic anemia occur usually secondary to thrombocytopenia and require frequent support with platelet concentrates and other blood products. Infection with dengue virus (particularly dengue sero type-2 of South Asian genotype) is associated with dengue haemorrhagic fever. Dengue infection further worsens the disease process in patients with aplastic anaemia due to uncontrolled haemorrhagic diathesis and major organ failure, which may prove fatal in these already immunocompromised patients, if not treated in time. Recent epidemics of dengue haemorrhagic fever has not only affected the southern region of our country but also spread to other areas of the country. With this background, we report a case of aplastic anaemia complicated by dengue haemorrhagic fever who achieved successful engraftment after allogeneic stem cell transplantation from sibling brother and is having normal healthy post transplant life.
authors.affiliation: Department of Haematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan.
authors.forename: Khalil
authors.initials: K
authors.lastname: Ullah
authors.forename: Tariq Mahmood
authors.initials: TM
authors.lastname: Satti
authors.forename: Parvez
authors.initials: P
authors.lastname: Ahmed
authors.forename: Shahid
authors.initials: S
authors.lastname: Raza
authors.forename: Waheed-Uz-Zaman
authors.initials: WU
authors.lastname: Tariq
authors.forename: Muhammad Khalid
authors.initials: MK
authors.lastname: Kamal
authors.forename: Qamar-Un-Nisa
authors.initials: QU
authors.lastname: Chaudhry
authors.forename: Farrukh Mahmood
authors.initials: FM
authors.lastname: Akhtar