Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis.
This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.
Bonfiglioli
Rubens
R
Unit of Rheumatology-Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences (FCM/UNICAMP), Barão Geraldo, Campinas-SP, CEP: 13081-970 Mail box 611, Brazil. pdsampaiobarros@uol.com.br
Conde
Roseneide A
RA
Sampaio-Barros
Percival D
PD
Louzada-Junior
Paulo
P
Donadi
Eduardo A
EA
Bertolo
Manoel B
MB
D000328:Adult; D000483:Alleles; D015535:Arthritis, Psoriatic / Q000208:ethnology* / Q000235:genetics*; D044383:Black People / Q000706:statistics & numerical data*; D001938:Brazil / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D044465:White People / Q000706:statistics & numerical data*
D015796:HLA-B27 Antigen