Impaired drinking capacity in patients with functional dyspepsia: intragastric distribution and distal stomach volume.
The water drink test is a good tool to evoke dyspeptic symptoms. To what extent these symptoms are related to altered gastric distribution is not clear. Therefore, we determined gastric volumes after a drink test using SPECT. After a baseline scan 20 healthy volunteers (HV) and 18 patients with functional dyspepsia (FD) underwent a drink test (100 mL min(-1)) followed by five scans up to 2 h. Dyspeptic symptoms were scored before every scan. A Wilcoxon signed rank test (P < 0.05) and a mixed effects model were used for statistical analyses. Fasting volumes were significantly higher in FD compared to HV for total, proximal and distal stomach (P < 0.001). Functional dyspeptic patients ingested significantly less water (P < 0.001) and had an impaired filling of the distal part of the stomach (P = 0.001) after the drink test. In FD, bloating (prox. 80%, dist. 56%), pain (prox. 87%, dist. 62%) and fullness (prox. 80%, dist. 59%) were determined more by proximal stomach volume rather than distal stomach volume. These data suggest that drinking capacity is mainly determined by antral volume, with a reduced antral filling in FD compared to HV. The persisting symptoms of bloating, pain and fullness in FD are predominantly associated with proximal stomach volume.
van den Elzen
B D
BD
Departments of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
Bennink
R J
RJ
Holman
R
R
Tytgat
G N
GN
Boeckxstaens
G E
GE
D000328:Adult; D004326:Drinking / Q000502:physiology*; D004415:Dyspepsia / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon