title: Comparative neuro tissue engineering using different nerve guide implants.
abstract: At the moment autologous nerve grafting remains the only reasonable technique for reconstruction of peripheral nerve defects. Unfortunately, this technique has a lot of complications and disadvantages. These problems are related to the autologous nerve that is harvested for this procedure. Donor site morbidity with loss of sensitivity, painful neuroma formation and of course the restricted availability of autologous nerves stimulates the idea for alternative techniques on that field. In this paper we describe our experience with different graft materials for reconstruction of a 2 cm nerve gap in a median nerve model in rats. After implantation of various materials (biological/synthetic) the main experiments were conducted with a synthetic, biodegradable nerve conduit seeded with autologous Schwann cells. With this material we were able to reconstruct successfully a 2 cm gap in the rat median nerve. Regeneration with this material was found to be equally to an autologous nerve graft.
authors.affiliation: Klinik für Hand-, Plastische-, Rekonstruktive- und Verbrennungschirurgie, Universität Tübingen, BG-Unfallklinik, Tübingen, Germany. nektarios.sinis@web.de
authors.forename: N
authors.initials: N
authors.lastname: Sinis
authors.forename: H E
authors.initials: HE
authors.lastname: Schaller
authors.forename: C
authors.initials: C
authors.lastname: Schulte-Eversum
authors.forename: T
authors.initials: T
authors.lastname: Lanaras
authors.forename: B
authors.initials: B
authors.lastname: Schlosshauer
authors.forename: M
authors.initials: M
authors.lastname: Doser
authors.forename: K
authors.initials: K
authors.lastname: Dietz
authors.forename: H
authors.initials: H
authors.lastname: Rösner
authors.forename: H W
authors.initials: HW
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Haerle
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D003094:Collagen; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D007783:Lactones; D008475:Median Nerve / Q000503:physiopathology / Q000601:surgery*; D009416:Nerve Regeneration; D011091:Polyesters; D011108:Polymers; D019736:Prostheses and Implants; D051381:Rats; D011917:Rats, Inbred Lew; D012825:Silicon; D023822:Tissue Engineering / Q000379:methods*; D014680:Veins / Q000637:transplantation
chemical_list: D007783:Lactones; D011091:Polyesters; D011108:Polymers; C410438:TMC-ECL copolymer; D003094:Collagen; D012825:Silicon