Organotin(IV) complexes of 2-pyridineformamide-derived thiosemicarbazones: antimicrobial and cytotoxic effects.
Reaction of n-butyltin trichloride [(n-Bu)SnCl(3)] with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives gave [(n-Bu)Sn(2Am4DH)Cl(2)] (1), [(n-Bu)Sn(2Am4Me)Cl(2)] (2), and [(n-Bu)Sn(2Am4Et)Cl(2)] (3). Thiosemicarbazones as well as their tin complexes are active as antimicrobials against the growth of Candida albicans and Salmonella typhimurium and were highly active against malignant glioblastoma. The cytotoxic activity of complexes 1-3 is similar. Among the studied compounds [(n-Bu)Sn(2Am4DH)Cl(2)] (1) was the most active as antiproliferative (cytostatic) agent. Thiosemicarbazones and their tin(IV) complexes proved to be more potent as cytotoxic agents than cisplatin. All the compounds were able to induce apoptosis.
Mendes
Isolda C
IC
Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Moreira
Juliana P
JP
Ardisson
José D
JD
Santos
Raquel Gouvea Dos
RG
da Silva
Paulo Roberto O
PR
Garcia
Isabel
I
Castiñeiras
Alfonso
A
Beraldo
Heloisa
H
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005559:Formamides / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009947:Organotin Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*; D014961:X-Ray Diffraction
C532279:2-pyridineformamide; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005559:Formamides; D009947:Organotin Compounds; D011725:Pyridines; D013882:Thiosemicarbazones