title: Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses.
abstract: Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
authors.affiliation: Department of Chemistry and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Jayanta
authors.initials: J
authors.lastname: Haldar
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Chen
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Tumpey
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Gubareva
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Klibanov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D053139:Oseltamivir / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000494:pharmacology; D053243:Zanamivir / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; C525941:N,N-dodecyl,methyl-polyethylenimine; D053139:Oseltamivir; D011094:Polyethyleneimine; D053243:Zanamivir