Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.
A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.
Mutoh
Norihiro
N
Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Japan. normutoh@inst-hsc.jp
Kitajima
Satoko
S
D003067:Coenzymes / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D025141:Drug Resistance, Fungal / Q000235:genetics; D005978:Glutathione / Q000172:deficiency*; D009154:Mutation; D012568:Schizosaccharomyces / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics*; D024483:Vitamin K 3 / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism
D003067:Coenzymes; D029702:Schizosaccharomyces pombe Proteins; D014815:Vitamins; C526400:sir2 protein, S pombe; D024483:Vitamin K 3; D003300:Copper; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc