title: Endoscopic reconstruction of large anterior skull base defects using acellular dermal allograft.
abstract: BACKGROUND
  Endoscopic repair of small- to medium-sized anterior skull base (ASB) defects using bone, cartilage, fascia, fibrin glue, lipolized dura, and, more recently, acellular dermal allograft have all been described with equal efficacy. The purpose of this study was to review our experience with the use of acellular dermis as the sole graft material in endoscopic reconstruction of large ASB defects.
  
  
  METHODS
  A retrospective chart review of all patients who underwent endoscopic repair of ASB defects at the University of Miami between the years of 2001 and 2006 was conducted. Fifty-six patients were identified who met these criteria. All repairs were performed by a transnasal, endoscopic approach. Outcome measures included success of graft take and incidence of major and minor complications. Dural defect size was defined as small (<0.4 cm), intermediate (0.4-2.0 cm), and large (>2.0 cm).
  
  
  RESULTS
  AlloDerm (AlloDerm. LifeCell Corp. Woodlands, TX) was used as the primary graft material in 30/55 (55%) cases; 16/55 (29%) of the repaired defects were classified as large. Graft success was 97% in the AlloDerm group and 92% in the non-AlloDerm group. The incidence of major and minor complications in the AlloDerm group was 0 and 3.3%, respectively. In the non-AlloDerm group, the incidence of major and minor complications was 4 and 12%, respectively. There were no statistical differences in the complication rates based on the type of repair or defect size.
  
  
  CONCLUSIONS
  Alloderm can be used successfully to repair ASB defects, including large defects that are >2 cm in size with little or no morbidity.
authors.affiliation: Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA. rgermani@med.miami.edu
authors.forename: Ross M
authors.initials: RM
authors.lastname: Germani
authors.forename: Richard
authors.initials: R
authors.lastname: Vivero
authors.forename: Islam R
authors.initials: IR
authors.lastname: Herzallah
authors.forename: Roy R
authors.initials: RR
authors.lastname: Casiano
mesh_terms: D002559:Cerebrospinal Fluid Rhinorrhea / Q000601:surgery; D003094:Collagen / Q000737:chemistry; D035262:Cranial Fossa, Anterior / Q000473:pathology* / Q000601:surgery*; D004724:Endoscopy / Q000379:methods*; D005005:Ethmoid Sinus / Q000473:pathology / Q000601:surgery; D006801:Humans; D009361:Neoplasm Invasiveness; D010255:Paranasal Sinus Neoplasms / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D019291:Skull Base / Q000473:pathology*
chemical_list: C440568:Alloderm; D003094:Collagen