title: Role of low-dose, noncontrast computed tomography from integrated positron emission tomography/computed tomography in evaluating incidental 2-deoxy-2-[F-18]fluoro-D-glucose-avid colon lesions.
abstract: OBJECTIVE
  To assess the contribution of concurrent low-dose, noncontrast CT in the assessment of the malignant potential of incidental focal 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-avid colonic lesions on positron emission tomography/computed tomography (PET/CT).
  
  
  METHODS
  Routine FDG-PET/CT scans were reviewed for identification of focal FDG-avid colon lesions, and the CT component was independently reviewed for an anatomical lesion and malignant potential based on CT criteria. Clinical, endoscopic, and histopathology follow-up was obtained.
  
  
  RESULTS
  A total of 85/2,916 (3%) oncology FDG-PET/CT scans had incidental focal colon lesions. Clinical and/or endoscopic follow-up was available in 83/85 (98%) patients. Focal, corresponding CT lesions were found in 44/83 (53%) patients, but features of malignancy were not assessable. Of the 44 patients with a final diagnosis, 32/44 (73%) were FDG-PET/CT true positives; 5/44 (11%) were false positives; and 7/44 (16%) had inconclusive FDG-PET/CT findings.
  
  
  CONCLUSIONS
  Concurrent low-dose, noncontrast CT improves localization, but does not provide independent information on the malignant potential of incidental focal colonic activity on FDG-PET/CT.
authors.affiliation: Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia. szeting.lee@auston.org.au
authors.forename: S T
authors.initials: ST
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Tan
authors.forename: A M T
authors.initials: AM
authors.lastname: Poon
authors.forename: H B
authors.initials: HB
authors.lastname: Toh
authors.forename: S
authors.initials: S
authors.lastname: Gill
authors.forename: S U
authors.initials: SU
authors.lastname: Berlangieri
authors.forename: E
authors.initials: E
authors.lastname: Kraft
authors.forename: A J
authors.initials: AJ
authors.lastname: Byrne
authors.forename: K
authors.initials: K
authors.lastname: Pathmaraj
authors.forename: G J
authors.initials: GJ
authors.lastname: O'Keefe
authors.forename: N
authors.initials: N
authors.lastname: Tebbutt
authors.forename: A M
authors.initials: AM
authors.lastname: Scott
mesh_terms: D003108:Colonic Diseases / Q000175:diagnosis*; D003287:Contrast Media / Q000378:metabolism*; D004724:Endoscopy; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18