Successful allogeneic stem cells transplantation in severe aplastic anaemia complicated by dengue Fever.
Aplastic anaemia is characterized by severe compromise of haematopoiesis and hypocellular bone marrow. Haemorrhagic episodes in patients with aplastic anemia occur usually secondary to thrombocytopenia and require frequent support with platelet concentrates and other blood products. Infection with dengue virus (particularly dengue sero type-2 of South Asian genotype) is associated with dengue haemorrhagic fever. Dengue infection further worsens the disease process in patients with aplastic anaemia due to uncontrolled haemorrhagic diathesis and major organ failure, which may prove fatal in these already immunocompromised patients, if not treated in time. Recent epidemics of dengue haemorrhagic fever has not only affected the southern region of our country but also spread to other areas of the country. With this background, we report a case of aplastic anaemia complicated by dengue haemorrhagic fever who achieved successful engraftment after allogeneic stem cell transplantation from sibling brother and is having normal healthy post transplant life.
Ullah
Khalil
K
Department of Haematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan.
Satti
Tariq Mahmood
TM
Ahmed
Parvez
P
Raza
Shahid
S
Tariq
Waheed-Uz-Zaman
WU
Kamal
Muhammad Khalid
MK
Chaudhry
Qamar-Un-Nisa
QU
Akhtar
Farrukh Mahmood
FM