title: Development and validation of diagnostic prediction model for solitary pulmonary nodules.
abstract: OBJECTIVE
  The aim of this study was to develop a simple prediction model for the underlying diagnosis of solitary pulmonary nodules (SPN) based on clinical characteristics and thin-section CT findings.
  
  
  METHODS
  Retrospective analysis was carried out on 452 patients with SPN (113 benign and 339 malignant) smaller than 30 mm, who underwent thin-section CT followed by surgical resection and histological diagnosis. The clinical characteristics were collected from medical records, and radiographic characteristics from thin-section CT findings. The prediction model was determined using multivariate logistic analysis. The prediction model was validated in 148 consecutive patients with undiagnosed SPN, and the diagnostic accuracy of the model was compared with that of an experienced chest radiologist.
  
  
  RESULTS
  The prediction model comprised the level of serum CRP, the level of carcinoembryonic antigen, the presence or absence of calcification, spiculation and CT bronchus sign. The areas under the receiver-operating characteristic curve in training and validation sets were 0.966 and 0.840, respectively. The diagnostic accuracies of the prediction model and the experienced chest radiologist for the validation set were 0.858 and 0.905, respectively.
  
  
  CONCLUSIONS
  The simple prediction model consisted of two biochemical and three radiographic characteristics. The diagnostic accuracy of an experienced chest radiologist was higher compared with the prediction model.
authors.affiliation: Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan. kyonemor@ncc.go.jp
authors.forename: Kan
authors.initials: K
authors.lastname: Yonemori
authors.forename: Ukihide
authors.initials: U
authors.lastname: Tateishi
authors.forename: Hajime
authors.initials: H
authors.lastname: Uno
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yonemori
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Hisao
authors.initials: H
authors.lastname: Asamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kusumoto
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D002097:C-Reactive Protein / Q000032:analysis; D002272:Carcinoembryonic Antigen; D002294:Carcinoma, Squamous Cell; D005260:Female; D006801:Humans; D016015:Logistic Models; D008171:Lung Diseases / Q000175:diagnosis*; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein