Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.
The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 microM, and relatively high cytotoxicity with a CC50 of 37 microM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 microM, but exhibited a far more less cytotoxicity (CC50 500 microM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.
Hosono
Tetsuji
T
Laboratory of Medicinal Microbiology, Yokohama College of Pharmacy, Kanagawa 245-0066, Japan. t.hosono@hamayaku.ac.jp
Yokomizo
Kazumi
K
Hamasaki
Akiyuki
A
Okamoto
Yoshinari
Y
Okawara
Tadashi
T
Otsuka
Masami
M
Mukai
Ryozaburo
R
Suzuki
Keitarou
K
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000998:Antiviral Agents; D011725:Pyridines; D006639:Histidine