Compounds from Vitex polygama active against kidney diseases.
Vitex polygama Cham. (Lamiaceae, formerly Verbenaceae) is a familiar Brazilian species popularly known as Tarumã whose leaf tea has been used by population to treat kidney diseases. The aim of this research was to investigate the hydroalcoholic extract of leaves in order to isolate the active compounds. Hydroalcoholic extract of leaves was obtained by stirring the previous hexane and methanol extracted leaves residue with 50% aqueous MeOH solution by ultra-sonic mixing. The obtained extract was partitioned with n-butanol. The yielded fraction was subsequently submitted to several chromatographic procedures to lead to the isolation of O-glycosidicflavones orientin and isoorientin as well as C-glycosylflavones schaftoside and carlinoside along with their isomers, known as potent anti-inflammatory, antinociceptive and antioxidant agents, then identified as the active constituents, justifying the folk use of the plant to combat and prevent kidney stone and inflammation.
Gallo
Margareth B C
MB
Departamento de Química, Universidade Federal de São Carlos, 13565-905 São Carlos, São Paulo, Brazil. margareth.gallo@gmail.com
Vieira
Paulo C
PC
Fernandes
João B
JB
da Silva
Maria Fátima das G F
MF
Salimena-Pires
Fátima R
FR
D001938:Brazil; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D020950:Vitex / Q000737:chemistry*
D047309:Flavones; D010936:Plant Extracts