Nonlinear modeling of cerebral state index in dogs.
The Cerebral State Index (CSI) is an electroencephalogram derived signal representing the depression of central nervous activity produced by anesthetic drugs. In this study, a nonlinear model was developed to describe the CSI tendency during general anesthesia in dogs, by evaluating the effect of the anesthetic drug propofol. The model was based on a compartmental and Hill Equation structure with individually identified parameters. The clinical data of 14 dog surgeries were collected and used for modeling and testing. The model presented good results, following the CSI trend. A model for drug-effect for veterinarian anesthesia is an important step when developing advisory, educational and control systems. The overall aim is to improve animal safety and comfort.
Brás
Susana
S
Faculdade de Ciências da Universidade do Porto, Departamento de Matemática Aplicada, Rua do Campo Alegre 687, Porto, Portugal. susana.bras@fc.up.pt
Bressan
Nadja
N
Ribeiro
Lénio
L
Ferreira
David A
DA
Antunes
Luís
L
Nunes
Catarina S
CS
D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000818:Animals; D054022:Cerebrum / Q000503:physiopathology*; D004285:Dogs; D004569:Electroencephalography; D005260:Female; D008297:Male; D008954:Models, Biological; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000008:administration & dosage
D018686:Anesthetics, Intravenous; D015742:Propofol