Modified end-to-side neurorrhaphy enhances axonal sprouting: a motor functional and morphological study.
This study evaluated the effect of modified end-to-side neurorrhaphy on functional recovery by modulating the epineurial window and contact areas, with a donor nerve, using a rat median nerve and finger flexors. Grasping testing, muscle contractility testing, and a histological study were performed 20 weeks after surgery. The modified end-to-side repair can enhance axonal sprouting from an intact nerve, and improve the functional recovery. Either the epineurial window surface area, or the contact configuration with the donor nerve is an important factors in an end-to-side coaptation model.
Kim
Byung Sung
BS
Soonchunhyang University College of Medicine, Bucheon, South Korea.
Choy
Won Sik
WS
Chung
Moon Sang
MS
Baek
Goo Hyun
GH
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001369:Axons / Q000502:physiology*; D004195:Disease Models, Animal; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D019635:Neurosurgical Procedures / Q000379:methods*; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D014459:Ulnar Nerve / Q000601:surgery