title: Estimating radiation dose from time to emesis and lymphocyte depletion.
abstract: Lymphocyte depletion kinetics and time to emesis have previously been shown to correlate with radiation dose. However, the method for estimating dose from lymphocyte counts was cumbersome, and a tabulation of estimated dose vs. time to emesis published by the International Atomic Energy Agency did not agree well with a regression of data from many (>100) radiation accident cases. The time-to-emesis data have been reanalyzed, and the new regression corroborates the previously published table. Also, dose estimation from post-exposure lymphocyte counts has been simplified and no longer requires serial calculations. Instead, dose can be estimated by a simple table lookup, given the ratio of two lymphocyte counts and the time between blood samples.
authors.affiliation: WriteSolutions, 155 Montana Avenue, Oak Ridge, TN 37830, USA. writesolutions@bellsouth.net
authors.forename: Denise D
authors.initials: DD
authors.lastname: Parker
authors.forename: Jack C
authors.initials: JC
authors.lastname: Parker
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018655:Lymphocyte Count; D008231:Lymphopenia / Q000473:pathology*; D008962:Models, Theoretical; D011832:Radiation Injuries / Q000097:blood*; D014839:Vomiting / Q000097:blood*