Emotional arousal enhances declarative memory in patients with Alzheimer's disease.
OBJECTIVE
To verify whether the long-term retention of an emotionally arousing story is stronger than the retention of a neutral story, and the enhancing effects of emotional arousal on declarative memory in Alzheimer's disease (AD) patients.


METHODS
Twenty subjects (10 with AD and 10 controls matched for age and educational level) were studied. After the audiovisual presentation (neutral story), the subjects rated the narrative's emotionality. Later, they answered a multiple-choice questionnaire about the stories. Two weeks later, they watched the emotionally arousing story.


RESULTS
Subjects who watched the emotionally arousing story assigned a score of emotionality higher than the subjects in the neutral group (P = 0.023). In addition, the participants remembered more details of the arousing story, and had a higher score in the questionnaire (P < 0.001).


CONCLUSIONS
We demonstrated that an emotionally arousing content enhances long-term declarative memory in AD. Furthermore, present finding supports the use of this instrument for clinical and research purposes.
Satler
C
C
Laboratory of Neurosciences and Behavior, and Faculty of Health Sciences, University of Brasília, Asa Norte, Brasília, DF, Brazil.
Garrido
L M
LM
Sarmiento
E P
EP
Leme
S
S
Conde
C
C
Tomaz
C
C
D000544:Alzheimer Disease / Q000503:physiopathology / Q000523:psychology*; D001143:Arousal / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires