Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid.
Altered functioning of the glutamate system during critical periods of development is believed to play a role in various neurodevelopmental disorders, such as schizophrenia. Prepulse inhibition (PPI) of the acoustic startle response is deficient in people with schizophrenia. This study investigated the theory that neonatal treatment with domoic acid (DOM), a glutamate agonist, leads to deficient PPI. Results indicate that neonatal treatment with DOM leads to lowered PPI in adult males and an increased startle response in adult females.
Adams
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Department of Biology, University of Prince Edward Island, Charlottetown, PEI, Canada.
Doucette
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Ryan
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D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000633:toxicity*; D051381:Rats; D012022:Reflex, Acoustic / Q000187:drug effects*; D013216:Reflex, Startle / Q000187:drug effects*; D012559:Schizophrenia / Q000139:chemically induced* / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
D009467:Neuromuscular Depolarizing Agents; D018698:Glutamic Acid; C012301:domoic acid; D007608:Kainic Acid