title: New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygen.
abstract: A 13-membered ring cyclic tetrapeptide was synthesized by the solid-phase peptide synthesis method, and its copper(II) coordination properties were analyzed by optical spectroscopy, mass spectrometry, and electrochemistry. All collected data strongly support the presence, at alkaline pH, of a stable peptide/copper(III) complex that is formed in solution by atmospheric dioxygen oxidation. On the basis of previous studies on cyclic peptide/copper systems, we suggest that the copper(III) ion is at the center of the ligand's cavity being coordinated to four deprotonated amide nitrogen atoms. This donor set would greatly lower the redox potential for the CuIII/CuII couple, thus allowing easy oxidation of the coordinated copper(II) by atmospheric oxygen.
authors.affiliation: PeptLab, Department of Organic Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pratesi
authors.forename: Piero
authors.initials: P
authors.lastname: Zanello
authors.forename: Gianluca
authors.initials: G
authors.lastname: Giorgi
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
authors.forename: Franco
authors.initials: F
authors.lastname: Laschi
authors.forename: Angela
authors.initials: A
authors.lastname: Casini
authors.forename: Maddalena
authors.initials: M
authors.lastname: Corsini
authors.forename: Chiara
authors.initials: C
authors.lastname: Gabbiani
authors.forename: Marco
authors.initials: M
authors.lastname: Orfei
authors.forename: Claudia
authors.initials: C
authors.lastname: Rosani
authors.forename: Mauro
authors.initials: M
authors.lastname: Ginanneschi
mesh_terms: D003300:Copper / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008667:Metalloproteins / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*
chemical_list: D008667:Metalloproteins; D003300:Copper; D010100:Oxygen