title: [Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis].
abstract: In recent years, bone quality is thought to be an important factor in bone strength. Vitamin K(2) (VK(2))drugs inhibit bone fracture, although their effect of increasing bone mineral density (BMD)is lower compared to bisphosphonate. This suggests VK(2) analogs improve bone quality. Glucocorticoid-induced osteoporosis(GIOP)brings about a bone fracture even under the condition of high BMD. VK(2) drugs might be effective to prevent bone fracture in GIOP, because they increase bone strength independently of bone mineral density (BMD).
authors.affiliation: Fujita Health University, Department of Clinical and Laboratory Medicine.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Tanaka
authors.forename: Hisaji
authors.initials: H
authors.lastname: Oshima
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D024482:Vitamin K 2 / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D024482:Vitamin K 2