[Value of plasma BNP levels as a prognostic marker in lung and heart disorders].
In this study we included 155 subjects, 35 patients with left heart failure, 49 chronic obstructive pulmonary disease (COPD)-cor pulmonale, 26 COPD, 20 pulmonary embolism and 25 healthy subjects. Plasma BNP level in patient with left heart failure was significantly higher than COPD-cor pulmonale, COPD and control subject in respect 1167 +/- 746, 434 +/- 55, 32 +/- 36 and 32 +/- 12 pg/mL. Plasma BNP in group of cor pulmonale was higher than COPD and control subject 434 +/- 55 vs. 32 +/- 12 pg/mL. There were no difference between COPD and control subject 32 +/- 36 vs. 32 +/- 12 pg/mL. In pulmonary embolism BNP was higher than controls 357 +/- 391 vs. 32 +/- 12 pg/mL and BNP levels of massive pulmonary embolism was higher non-massive embolism 699 +/- 394 vs 166 +/- 213 pg/mL. In this study BNP levels negative correlated with EF and positive correlated with pulmonary artery pressure. We suggest that increased BNP levels are correlated with ventricular failure and BNP is diagnostic and prognostic marker of heart failure and increased right ventricular pressure contributes to elevated BNP in patients with PE.
Yetkin
Ozkan
O
Department of Chest Diseases, Faculty of Medicine, Inönü University, Malatya, Turkey. ozkanyetkin@hotmail.com
Aksoy
Yüksel
Y
Turhan
Hasan
H
In
Erdal
E
Karahan
Mukadder
M
Kiliç
Talat
T
Hacievliyagil
Süleyman Savaş
SS
Günen
Hakan
H
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications; D011660:Pulmonary Heart Disease / Q000097:blood* / Q000150:complications
D020097:Natriuretic Peptide, Brain