title: [Preparation of kangfuxin colon targeting micro-pellets].
abstract: OBJECTIVE
  To prepare coated micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect.
  
  
  METHODS
  We eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidized bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork.
  
  
  RESULTS
  The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets.
  
  
  CONCLUSIONS
  We get two micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Xue-lan
authors.initials: XL
authors.lastname: Qiu
authors.forename: Xing-liang
authors.initials: XL
authors.lastname: Xie
authors.forename: Juan
authors.initials: J
authors.lastname: Lai
authors.forename: Si-wei
authors.initials: SW
authors.lastname: Chen
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008419:Materia Medica / Q000008:administration & dosage* / Q000302:isolation & purification / Q000378:metabolism; D008747:Methylcellulose / Q000031:analogs & derivatives; D010368:Pectins; D010526:Periplaneta / Q000737:chemistry; D011109:Polymethacrylic Acids
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008419:Materia Medica; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D065347:Hypromellose Derivatives; D010368:Pectins; D008747:Methylcellulose