title: Functional mitral regurgitation after a first non-ST-segment elevation acute coronary syndrome: contribution to congestive heart failure.
abstract: OBJECTIVE
  Functional mitral regurgitation (MR) is a frequent complication after the acute phase of a myocardial infarction and plays an important role in the development of congestive heart failure (CHF) after a Q-wave myocardial infarction. Nevertheless, until now, the relevance of functional MR after a non-ST-segment elevation acute coronary syndrome (NSTSEACS) has been poorly addressed. Our aim was to assess the relationship between the presence or absence and the severity of functional MR after a first NSTSEACS and the development of CHF.
  
  
  RESULTS
  Two hundred and seventy-nine patients discharged from hospital in NYHA functional classes I and II (71.7% men; mean age 66.3 +/- 13.2 years) after a first NSTSEACS were studied. Every patient underwent an echocardiographic study during the first week after the index NSTSEACS and were clinically followed-up. MR was detected in 40.1% patients. Patients were followed-up for a median time of 418 days (inter-quartile range: 295-561). Six patients (3.6%) in the group without MR and 15 patients (13.4%) in the group with MR required hospitalization due to CHF during follow-up. Only MR was found as an independent predictor of CHF development (HR = 1.8; 95% CI = 1.1-3.1; P = 0.02) and CHF development or cardiac death (HR = 2.1; 95% CI = 1.3-3.3; P = 0.01) in the long-term follow-up multivariable Cox regression analysis.
  
  
  CONCLUSIONS
  There is an increased risk for subsequent CHF in patients with MR after a first NSTSEACS. The risk of CHF is closely related to the MR presence and severity. Thus, the detection of MR by means of Doppler echocardiography after a first episode of NSTSEACS is crucial.
authors.affiliation: Unidad de Imagen Cardiovascular, Instituto Cardiovascular, Hospital Clínico San Carlos, Plaza Cristo Rey, 28040 Madrid, Spain. jlzamorano@vodafone.es
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Pérez de Isla
authors.forename: Jose
authors.initials: J
authors.lastname: Zamorano
authors.forename: Maribel
authors.initials: M
authors.lastname: Quezada
authors.forename: Carlos
authors.initials: C
authors.lastname: Almería
authors.forename: José Luis
authors.initials: JL
authors.lastname: Rodrigo
authors.forename: Viviana
authors.initials: V
authors.lastname: Serra
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Garcia Rubira
authors.forename: Antonio Fernandez
authors.initials: AF
authors.lastname: Ortiz
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000401:mortality; D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods; D004452:Echocardiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality; D018570:Risk Assessment; D012307:Risk Factors