title: Case of recurrent paracoccidioidomycosis in female. 10 years after initial treatment.
abstract: This report describes a case of recurrence of chronic paracoccidioidomycosis 10 years following the initial diagnosis. A 56-year-old female was admitted to the Dental Clinic of the Pontifical Catholic University of Paraná complaining of oral soreness. Mulberry-like ulcerations were observed on the gingiva, right labial comissura, and vermillion of the lip. The patient reported persistent chronic cough, weight loss, appetite loss and fever. The anamnesis revealed that the patient had developed and been treated for paracoccidioidomycosis 10 years earlier. A biopsy was performed and microscopic examination revealed microabscesses, collections of macrophages organized into granulomas, multinucleated giant cells and Paracoccidioides brasiliensis. The patient was treated with Itraconazole and, the oral lesions disappeared within 3 months. Persistent follow-up examination in patients with a history of paracoccidioidomycosis is essential in the management of this disease.
authors.affiliation: Department of Stomatology, School of Dentistry, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil.
authors.forename: Ana Claudia Santos
authors.initials: AC
authors.lastname: De Azevedo Izidoro
authors.forename: Paulo Cesar
authors.initials: PC
authors.lastname: Da Silva
authors.forename: Marina
authors.initials: M
authors.lastname: De Oliveira Ribas
authors.forename: Luciana Reis
authors.initials: LR
authors.lastname: De Azevedo
authors.forename: Maria Angela Naval
authors.initials: MA
authors.lastname: Machado
authors.forename: Antonio Adilson Soares
authors.initials: AA
authors.lastname: De Lima
mesh_terms: D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000382:microbiology; D005882:Gingival Diseases / Q000382:microbiology*; D006801:Humans; D008047:Lip Diseases / Q000382:microbiology*; D008264:Macrophages / Q000382:microbiology; D008875:Middle Aged; D009059:Mouth Diseases / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology; D010228:Paracoccidioides / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000175:diagnosis*; D012008:Recurrence