The effect of sodium alginate on physical and dissolution properties of Surelease-matrix pellets prepared by a novel pelletizer.
The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (e(R)) and the aspect ratio of Surelease-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release rate than the drug release mechanism within the Surelease-matrix for sparingly water-soluble drug, such as tamsulosin hydrochloride.
Kim
Min-Soo
MS
National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, Daejeon, Korea.
Kim
Jeong-Soo
JS
Hwang
Sung-Joo
SJ
D000464:Alginates / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry; D013499:Surface Properties; D000077409:Tamsulosin; D014867:Water / Q000737:chemistry
D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D013449:Sulfonamides; D014867:Water; C013517:ethyl cellulose; D020723:Glucuronic Acid; D002482:Cellulose; D000077409:Tamsulosin