title: Neoplastic precursor lesions related to the development of cancer in inflammatory bowel disease.
abstract: Dysplasia is an intermediate stage in the progression from inflammation to cancer in patients with inflammatory bowel disease. Clinically, dysplasia is used to define appropriate endpoints for colectomy in high-risk patients undergoing endoscopic surveillance. Surveillance is currently the only credible alternative to prophylactic colectomy for high-risk patients. The success of surveillance can be maximized by adherence of gastroenterologists to recommended procedural guidelines, adherence of pathologists to standardized histological criteria and nomenclature, and a joint commitment to close clinical-pathological communication. Technical enhancements to conventional endoscopy hold promise of improved efficiency and accuracy. Molecular-based testing may have a future role for risk stratification and early detection of neoplasia in inflammatory bowel disease.
authors.affiliation: Division of Gastrointestinal Pathology, Department of Pathology, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA. noam.harpaz@msnyuhealth.org
authors.forename: Noam
authors.initials: N
authors.lastname: Harpaz
mesh_terms: D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors