title: Synthesis and anticancer activities of novel 1,4-disubstituted phthalazines.
abstract: A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China. lijuan107628@sian.com
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Zhao
authors.forename: Xiao-Ye
authors.initials: XY
authors.lastname: Yuan
authors.forename: Jing-Xiong
authors.initials: JX
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D005354:Fibrosarcoma / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C104226:3-hydroxy-3-methyl-1(3H)-isobenzofuranone; D000970:Antineoplastic Agents; D001572:Benzofurans; D010793:Phthalazines