title: Engineering and applications of genetic circuits.
abstract: In the field of synthetic biology, recent genetic engineering efforts have enabled the construction of novel genetic circuits with diverse functionalities and unique activation mechanisms. Because of these advances, artificial genetic networks are becoming increasingly complex, and are demonstrating more robust behaviors with reduced crosstalk between defined modules. These properties have allowed for the identification of a growing set of design principles that govern genetic networks, and led to an increased number of applications for genetic circuits in the fields of metabolic engineering and biomedical engineering. Such progress indicates that synthetic biology is rapidly evolving into an integrated engineering practice that uses rational and combinatorial design of synthetic gene networks to solve complex problems in biology, medicine, and human health.
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst, 686 N. Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sayut
authors.forename: Pavan Kumar Reddy
authors.initials: PK
authors.lastname: Kambam
authors.forename: Lianhong
authors.initials: L
authors.lastname: Sun
mesh_terms: D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000235:genetics*; D005818:Genetic Engineering; D006801:Humans