Discovery of motifs in promoters of coregulated genes.
We present a method to predict cis-acting elements by detecting over-represented motifs in promoters of a set of coregulated genes (single-genome, multigenes approach). The method has been used successfully to detect regulating elements in bacteria and yeast. It can be used with higher organisms as well, but with a loss in reliability of the predictions. A web interface is available at the Regulatory Sequence Analysis Tools site (http://rsat.scmbb.ulb.ac.be/rsat/).
Sand
Olivier
O
Service de Conformation des Macromolécules, Biologiques et de Bioinformatiques, Université Libre de Bruxelles, Belgium.
van Helden
Jacques
J
D005786:Gene Expression Regulation; D020407:Internet; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic; D014584:User-Computer Interface