Successful liver retransplantation for recurrent hepatopulmonary syndrome.
HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of OLT, but recurred again at 12 months post-OLT following liver dysfunction secondary to a biliary stricture. She underwent a second OLT successfully and remains well two yr and three months post-second OLT. Recurrent HPS after OLT may occur because of graft dysfunction and as this novel case illustrates, retransplantation may lead to a successful outcome.
Rajwal
S R
SR
Children's Liver and GI Unit, St. James's University Hospital, Leeds, UK. sanjay.rajwal@leedsth.nhs.uk
Davison
S M
SM
Prasad
R
R
Brownlee
K
K
McClean
P
P
D000293:Adolescent; D000792:Angiography; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005500:Follow-Up Studies; D020065:Hepatopulmonary Syndrome / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D012008:Recurrence; D012086:Reoperation; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed