title: Quantifying asthma symptoms in adults: the Lara Asthma Symptom Scale.
abstract: BACKGROUND
  Accurate assessment of asthma symptoms is critical in research and clinical settings. A multidimensional asthma control questionnaire could provide more accurate information about asthma symptoms than global assessments, which often overestimate asthma control.
  
  
  OBJECTIVE
  We sought to evaluate the efficacy of the Lara Asthma Symptom Scale (LASS) in adults with persistent asthma.
  
  
  METHODS
  Participants were 18 to 64 years of age with persistent asthma. Data were collected at baseline, 6 months, and 12 months. We described the construct and predictive validity of the LASS by comparing it with measures of pulmonary function (FEV(1)), asthma-specific quality of life (Juniper's Asthma Quality of Life Questionnaire [AQLQ]), and health care use (emergency department [ED] visits and hospitalizations).
  
  
  RESULTS
  Three hundred eighty-three participants provided baseline data. The LASS had high internal consistency reliability (Cronbach alpha = .84). LASS scores correlated significantly with baseline measures of FEV(1) (-0.20, P = .0002), AQLQ (-0.68, P < .0001), ED visits (0.17, P = .002), and hospitalizations (0.15, P = .008). Baseline LASS scores were associated significantly with ED visits (P = .03) and hospitalizations (P = .04) over the subsequent 12 months. Change in LASS scores over time correlated significantly with changes in FEV(1) (-0.22, P = .001) and AQLQ (-0.70, P < .001).
  
  
  CONCLUSIONS
  The LASS demonstrated good internal consistency, excellent validity based on concurrent criterion validity and longitudinal predictive validity, and good discriminatory properties in a heterogeneous sample of adults with persistent asthma.
  
  
  CONCLUSIONS
  This study validates a simple multidimensional asthma questionnaire as a clinical tool in the assessment of asthma control in adults.
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. woodp@uthscsa.edu
authors.forename: Pamela Runge
authors.initials: PR
authors.lastname: Wood
authors.forename: Brad
authors.initials: B
authors.lastname: Smith
authors.forename: Louise
authors.initials: L
authors.lastname: O'Donnell
authors.forename: Autumn Dawn
authors.initials: AD
authors.lastname: Galbreath
authors.forename: Marielena
authors.initials: M
authors.lastname: Lara
authors.forename: Emma
authors.initials: E
authors.lastname: Forkner
authors.forename: Jay I
authors.initials: JI
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires