Sickle cell disease complicated by post-streptococcal glomerulonephritis, cerebral hemorrhage and reversible posterior leucoencephalopathy syndrome.
A patient with homozygous hemoglobin SS disease presented with an intracerebral hemorrhage complicating reversible posterior leucoencephalopathy syndrome (RPLS), secondary to hypertension associated with acute post-streptococcal glomerulonephritis (APSGN). Distinguishing potentially reversible causes of central nervous system events from primary cerebral infarction or hemorrhage in patients with sickle cell disease is important because the management and prognosis of these complications is very different. Similarly, because of the difference in prognosis between APSGN and other forms of sickle cell nephropathy, it is also important to differentiate these conditions.
Pashankar
Farzana D
FD
Department of Pediatrics and Neurology, Yale University School of Medicine, New Haven, Connecticut, USA. Farzana.Pashankar@yale.edu
Ment
Laura R
LR
Pearson
Howard A
HA
D000755:Anemia, Sickle Cell / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002648:Child; D005921:Glomerulonephritis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000209:etiology* / Q000503:physiopathology; D013290:Streptococcal Infections / Q000150:complications* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed