title: Synthesis of dendrimers and drug-dendrimer conjugates for drug delivery.
abstract: Dendrimers constitute a class of polymers that possess a well-defined structure allowing the precise control of size, shape and terminal group functionality. Their utility has been explored for a wide range of pharmaceutical applications. There is growing interest in the design and synthesis of novel biocompatible dendrimers and a number of novel dendrimer architectures are discussed in this review. Recently, there has also been interest in the design of drug-dendrimer prodrugs and several of these systems are described, with emphasis on how the properties of such carriers may be tailored via surface engineering.
authors.affiliation: University of Central Lancashire, School of Pharmacy and Pharmaceutical Sciences, Preston, Lancashire, UK.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Najlah
authors.forename: Antony
authors.initials: A
authors.lastname: D'Emanuele
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D015394:Molecular Structure; D050997:Nanomedicine / Q000379:methods; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; C104700:PAMAM Starburst; D004364:Pharmaceutical Preparations; D011073:Polyamines; D011355:Prodrugs