Activity-based fluorescent reporters for monoamine oxidases in living cells.
Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.
Albers
Aaron E
AE
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Rawls
Katherine A
KA
Chang
Christopher J
CJ
D000818:Animals; D004789:Enzyme Activation; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000737:chemistry*; D016716:PC12 Cells; D051381:Rats; D013997:Time Factors
D005456:Fluorescent Dyes; D008995:Monoamine Oxidase