title: A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000).
abstract: The Chornobyl (Chernobyl) accident in 1986 exposed many individuals to radioactive iodines, chiefly (131)I, the effects of which on benign thyroid diseases are largely unknown. To investigate the risk of follicular adenoma in relation to radiation dose after Chornobyl, the authors analyzed the baseline data from a prospective screening cohort study of those exposed as children or adolescents. A stratified random sample was selected from all individuals who were younger than 18 years, had thyroid radioactivity measurements taken within 2 months after the accident, and resided in the three heavily contaminated areas in Ukraine. This analysis is based on the 23 cases diagnosed in 12,504 subjects for whom personal history of thyroid diseases was known. The dose-response relation was linear with an excess relative risk of 2.07 per gray (95% confidence interval: 0.28, 10.31). The risk was significantly higher in women compared with men, with no clear modifying effects of age at exposure. In conclusion, persons exposed to radioactive iodines as children and adolescents have an increased risk of follicular adenoma, though it is smaller than the risk of thyroid cancer in the same cohort. Compared with results from other studies, this estimate is somewhat smaller, but confidence intervals overlap, suggesting compatibility.
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. lbz7@columbia.edu
authors.forename: Lydia B
authors.initials: LB
authors.lastname: Zablotska
authors.forename: Tetyana I
authors.initials: TI
authors.lastname: Bogdanova
authors.forename: Elaine
authors.initials: E
authors.lastname: Ron
authors.forename: Ovsiy V
authors.initials: OV
authors.lastname: Epstein
authors.forename: Jacob
authors.initials: J
authors.lastname: Robbins
authors.forename: Illya A
authors.initials: IA
authors.lastname: Likhtarev
authors.forename: Maureen
authors.initials: M
authors.lastname: Hatch
authors.forename: Valentyn V
authors.initials: VV
authors.lastname: Markov
authors.forename: Andre C
authors.initials: AC
authors.lastname: Bouville
authors.forename: Valery A
authors.initials: VA
authors.lastname: Olijnyk
authors.forename: Robert J
authors.initials: RJ
authors.lastname: McConnell
authors.forename: Victor M
authors.initials: VM
authors.lastname: Shpak
authors.forename: Alina
authors.initials: A
authors.lastname: Brenner
authors.forename: Galina N
authors.initials: GN
authors.lastname: Terekhova
authors.forename: Ellen
authors.initials: E
authors.lastname: Greenebaum
authors.forename: Valery P
authors.initials: VP
authors.lastname: Tereshchenko
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Fink
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Brill
authors.forename: Galina A
authors.initials: GA
authors.lastname: Zamotayeva
authors.forename: Ihor J
authors.initials: IJ
authors.lastname: Masnyk
authors.forename: Geoffrey R
authors.initials: GR
authors.lastname: Howe
authors.forename: Mykola D
authors.initials: MD
authors.lastname: Tronko
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007455:Iodine / Q000172:deficiency; D016015:Logistic Models; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011874:Radiometry; D012307:Risk Factors; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014455:Ukraine / Q000453:epidemiology
chemical_list: D007455:Iodine