Evaluation of selected micronized poloxamers as tablet lubricants.
The primary objective of this study was to compare the lubrication properties of micronized poloxamer 188 (Lmicrotrol micro 68) and micronized poloxamer 407 (Lmicrotrol micro 127) with certain conventional lubricants such as magnesium stearate and stearic acid. The secondary objective was to use these micronized poloxamers as water-soluble tablet lubricants in preparation of effervecsent tablets. The results showed that these micronized poloxamers have superior lubrication properties compared with stearic acid, with no negative effect on tablet hardness, friability, disintegration, or dissolution. Moreover, lubricant mixing time had no significant effect on tablet properties when poloxamers were used as lubricants. Effervescent tablets also were produced successfully using micronized poloxamers as lubricants. The micronized poloxamers had a better lubrication effect in comparison with that of water-soluble lubricant l-leucine.
Desai
D
D
Department of Pharmaceutics, Collage of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Zia
H
H
Quadir
A
A
D000082:Acetaminophen / Q000737:chemistry; D001241:Aspirin / Q000737:chemistry; D002110:Caffeine / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D057927:Hydrophobic and Hydrophilic Interactions; D007930:Leucine / Q000737:chemistry; D054327:Lubricants / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D013229:Stearic Acids / Q000737:chemistry; D013499:Surface Properties; D013607:Tablets
D005079:Excipients; D054327:Lubricants; D013229:Stearic Acids; D013607:Tablets; D020442:Poloxamer; D000082:Acetaminophen; D002110:Caffeine; C031183:stearic acid; D007930:Leucine; D001241:Aspirin