title: gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acids.
abstract: A facile synthesis of alpha,beta-unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids.
authors.affiliation: Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India. john.kallikat@syngeneintl.com
authors.forename: John Kallikat
authors.initials: JK
authors.lastname: Augustine
authors.forename: Yanjerappa Arthoba
authors.initials: YA
authors.lastname: Naik
authors.forename: Ashis Baran
authors.initials: AB
authors.lastname: Mandal
authors.forename: Nagaraja
authors.initials: N
authors.lastname: Chowdappa
authors.forename: Vinuthan B
authors.initials: VB
authors.lastname: Praveen
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001555:Benzene Derivatives; D002264:Carboxylic Acids; D008314:Malonates; C030290:malonic acid