title: Mechanical forces and human saphenous veins: coronary artery bypass graft implications.
abstract: Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynamic, functional and morphological human saphenous veins alterations caused by these different forces with conflictant results. This review text was motivated with the specific aim of analyze literature data and some experimental data carried out in our laboratory. The adopted review subjects were: 1) Endothelial responses and gene regulation to shear stress; 2) Effects of the hydrostatic pressure in the endothelial cell morphology, gene expression of the endothelial cellular surface and proliferation of endothelial cells; 3) Effects of the traction on the human saphenous vein endothelium.
authors.affiliation: Surgery and Anatomy Department of the Medical School in Ribeirão Preto of the University of São Paulo.
authors.forename: Rafael Angelo
authors.initials: RA
authors.lastname: Tineli
authors.forename: Fernanda
authors.initials: F
authors.lastname: Viaro
authors.forename: Marcelo Bellini
authors.initials: MB
authors.lastname: Dalio
authors.forename: Graziela Saraiva
authors.initials: GS
authors.lastname: Reis
authors.forename: Solange
authors.initials: S
authors.lastname: Basseto
authors.forename: Walter Villela de Andrade
authors.initials: WV
authors.lastname: Vicente
authors.forename: Alfredo José
authors.initials: AJ
authors.lastname: Rodrigues
authors.forename: Paulo Roberto Barbosa
authors.initials: PR
authors.lastname: Evora
mesh_terms: D000818:Animals; D001026:Coronary Artery Bypass; D042783:Endothelial Cells / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D006874:Hydrostatic Pressure; D012501:Saphenous Vein / Q000502:physiology* / Q000637:transplantation; D033081:Shear Strength; D013314:Stress, Mechanical; D020858:Tissue and Organ Harvesting / Q000379:methods; D014654:Vascular Patency