Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis.
We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.
Domínguez
Jose
J
Servei de Microbiologia, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Barcelona, Spain. jadominguez.igtp.germanstrias@gencat.net
Ruiz-Manzano
Juan
J
De Souza-Galvão
Malú
M
Latorre
Irene
I
Milà
Celia
C
Blanco
Silvia
S
Jiménez
M Angeles
MA
Prat
Cristina
C
Lacoma
Alicia
A
Altet
Neus
N
Ausina
Vicente
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D010455:Peptides / Q000276:immunology; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D014374:Tuberculin Test / Q000379:methods; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D010455:Peptides; D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma