Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?
OBJECTIVE
Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population.


METHODS
Mitochondrial DNA haplogroups M, N, J and K were studied by PCR-restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons.


RESULTS
There were no statistically significant differences between those with TB and the control group.


CONCLUSIONS
There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.
Houshmand
Massoud
M
National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
Banoei
Mohammad Mehdi
MM
Tabarsi
Payam
P
Panahi
Mehdi Shafa Shariat
MS
Hooshiar Kashani
Baharak
B
Ebrahimi
Golnaz
G
Zargar
Laleh
L
Farnia
Parissa
P
Morris
Matthew W
MW
Mansouri
Davood
D
Velayati
Ali Akbar
AA
Mirsaeidi
Mehdi S
MS
D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
D004272:DNA, Mitochondrial