title: [Daily interruption of sedation in intensive care unit patients with renal impairment: remifentanil-midazolam compared to fentanyl-midazolam].
abstract: OBJECTIVE
  We compared extubation time following daily interruption of sedation in intensive care unit patients with renal impairment with two sedation regimes remifentanil-midazolam and fentanyl-midazolam.
  
  
  METHODS
  Prospective, randomized double-blind trial.
  
  
  METHODS
  Patients with renal impairment needing mechanical ventilation for more than 48 hours. Two groups: remifentanil (R) and fentanyl (F), Infusion rates were titrated to achieve the desired Ramsay score. The two groups received midazolam (2.5 mg then 0.1 mg/kg/h).
  
  
  RESULTS
  Nineteen patients were included. Patient's characteristics, mean sedation time and sedation quality were comparable. Extubation time was significantly shorter in R group (1480+/-980 versus 2880+/-1280 min, P=0.04). Weaning time was also shorter in R group (220+/-164 versus 720+/-480 min). Agitation on weaning was comparable in the two groups. Group R received significantly more morphine than group F after interruption of sedation.
  
  
  CONCLUSIONS
  Daily interruption of sedation with remifentanil is associated with shorter weaning and extubation time in patients with renal impairment. However further studies are necessary to determine if this issue is associated with lower rate of ventilation induced complications.
authors.affiliation: Service d'anesthésie-réanimation, hôpital militaire principal d'instruction de Tunis, 1008 Tunis, Tunisie. mondherbenhaj@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Belhadj Amor
authors.forename: R
authors.initials: R
authors.lastname: Ouezini
authors.forename: K
authors.initials: K
authors.lastname: Lamine
authors.forename: M
authors.initials: M
authors.lastname: Barakette
authors.forename: I
authors.initials: I
authors.lastname: Labbène
authors.forename: M
authors.initials: M
authors.lastname: Ferjani
mesh_terms: D019162:Anesthetics, Combined / Q000008:administration & dosage*; D016292:Procedural Sedation / Q000379:methods*; D003422:Critical Care; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007362:Intensive Care Units; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D011446:Prospective Studies; D000077208:Remifentanil; D051437:Renal Insufficiency
chemical_list: D019162:Anesthetics, Combined; D006993:Hypnotics and Sedatives; D010880:Piperidines; D000077208:Remifentanil; D008874:Midazolam; D005283:Fentanyl