[Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis].
Activation of PI3K is a key step of intracellular signaling involved in many cellular functions. PI3K inhibitors have shown anti-rheumatic effects on arthritis model in mice. PI3K is a potential therapeutic target of rheumatoid arthritis.
Tamura
Naoto
N
Department of Internal Medicine and Rheumatology Juntendo University School of Medicine.
Haruta
Kazuhiko
K
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011810:Quinoxalines / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000627:therapeutic use
D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011810:Quinoxalines; D045162:Thiazolidinediones; C505144:5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione