Serotonin-1A receptors in frontotemporal dementia compared with controls.
Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT(1A) binding potential (BP) compared with controls in all 10 brain regions examined. These pilot data suggest that profound 5-HT(1A) BP losses may be present and contribute to symptomatology and treatment response in FTLD.
Lanctôt
Krista L
KL
Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. krista.lanctot@sunnybrook.ca
Herrmann
Nathan
N
Ganjavi
Hooman
H
Black
Sandra E
SE
Rusjan
Pablo M
PM
Houle
Sylvain
S
Wilson
Alan A
AA
D000368:Aged; D001665:Binding Sites; D003704:Dementia / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*
D044282:Receptor, Serotonin, 5-HT1A