title: Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I.
abstract: OBJECTIVE
  The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD).
  
  
  METHODS
  Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis.
  
  
  RESULTS
  The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients.
  
  
  CONCLUSIONS
  This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.
authors.affiliation: Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands. p.aalten@np.unimaas.nl
authors.forename: Pauline
authors.initials: P
authors.lastname: Aalten
authors.forename: Frans R J
authors.initials: FR
authors.lastname: Verhey
authors.forename: Marina
authors.initials: M
authors.lastname: Boziki
authors.forename: Roger
authors.initials: R
authors.lastname: Bullock
authors.forename: Eleanor Jane
authors.initials: EJ
authors.lastname: Byrne
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.forename: Miriam
authors.initials: M
authors.lastname: Caputo
authors.forename: Debby
authors.initials: D
authors.lastname: Collins
authors.forename: Peter Paul
authors.initials: PP
authors.lastname: De Deyn
authors.forename: Kazi
authors.initials: K
authors.lastname: Elina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frisoni
authors.forename: Nicola
authors.initials: N
authors.lastname: Girtler
authors.forename: Clive
authors.initials: C
authors.lastname: Holmes
authors.forename: Catherine
authors.initials: C
authors.lastname: Hurt
authors.forename: Anna
authors.initials: A
authors.lastname: Marriott
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Pierre Jean
authors.initials: PJ
authors.lastname: Ousset
authors.forename: Emma
authors.initials: E
authors.lastname: Reynish
authors.forename: Eric
authors.initials: E
authors.lastname: Salmon
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Philippe H
authors.initials: PH
authors.lastname: Robert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology*; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D012720:Severity of Illness Index