A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania.
OBJECTIVE
Patients with bipolar disorder have changes in brain structures but it is unclear if these are present at disease onset and thus predispose subjects to develop the disorder, or whether they develop during the course of the disorder, either due to the effects of multiple episodes or as a consequence of treatment with psychotropic agents. Studies in first-episode (FE) manic patients have the potential to provide answers to these questions.


METHODS
Voxel-based morphometry (VBM) was used to assess magnetic resonance imaging scans of 15 FE manic patients and 15 matched healthy controls.


RESULTS
Using a priori defined statistical criteria, no significant differences in brain structures were noted between the two groups. However, there was approximately a 6% reduction in left anterior cingulate, left precuneus and right posterior cingulate volume in FE patients and these reductions were significant (p<or=0.002) at uncorrected levels.


CONCLUSIONS
First-episode manic patients have reductions in left anterior, right posterior cingulate as well as left precuneus volumes, but these reductions are smaller and likely worsen with further mood episodes in bipolar patients.
Yatham
Lakshmi N
LN
Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada. yatham@interchange.ubc.ca
Lyoo
In Kyoon
IK
Liddle
Peter
P
Renshaw
Perry F
PF
Wan
Dante
D
Lam
Raymond W
RW
Hwang
Jaeuk
J
D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors
D000927:Anticonvulsants; D014150:Antipsychotic Agents