title: Mechanism of permeation in calcium channels activation by applied magnetic fields.
abstract: In this paper, a Brownian dynamics model of cell membrane calcium ion channels exposure to ELF magnetic fields has been proposed for the first time. Based on the model, the permeation of calcium channels activation by applied magnetic fields is given here. The number of opened calcium channel is increase with magnetic fields. The currents of calcium ions in the channel in controls and exposure to ELF magnetic fields are almost the same. These results are consistent with experiments. Thus it can be seen that the current of single calcium channel was nearly unaffected by applied magnetic fields, the increased number of opened calcium channel may be the reason of increased intracellular calcium concentration.
authors.affiliation: School of Sciences, Hebei University of Technology, Tianjin, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yu-Hong
authors.forename: Zhan
authors.initials: Z
authors.lastname: Yong
authors.forename: Zhao
authors.initials: Z
authors.lastname: Tong-Jun
authors.forename: Han
authors.initials: H
authors.lastname: Ying-Rong
authors.forename: Liu
authors.initials: L
authors.lastname: Hui
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology* / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000502:physiology / Q000528:radiation effects; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D015640:Ion Channel Gating / Q000502:physiology* / Q000528:radiation effects*; D008954:Models, Biological; D011829:Radiation Dosage
chemical_list: D015220:Calcium Channels; D002118:Calcium