Correlation between lipoprotein(a) serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score.
OBJECTIVE
To investigate the correlation between serum lipoprotein(a) concentration and existence as well as severity of coronary atherosclerosis.


METHODS
A cross-sectional study was conducted on 826 patients who underwent angiography through measuring blood sugar, serum lipids, lipoprotein(a) and evaluation of coronary stenosis by Gensini score.


RESULTS
Gensini score=6 was considered as a cut-off point for coronary disease and 40 mg/dL was determined as lipoprotein(a) cut-off point. Its higher concentration was significantly more frequent in patients with Gensini score>6 (OR: 2.50, p=0.001), independent of gender, smoking, diabetes mellitus and hyperlipidemia. This finding was significant in patients <55 years old. There was a significant relationship between severity of coronary stenosis and higher concentration of serum lipoprotein(a).


CONCLUSIONS
LP(a) serum concentration is an independent risk factor for coronary atherosclerosis in the Iranian population especially at the ages below 55. Also it demonstrates a direct relationship between severity of coronary atherosclerosis (by Gensini score) and serum LP(a).
Boroumand
Mohammad Ali
MA
Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran. borumand@sina.tums.ac.ir
Rekabi
Vahab
V
Davoodi
Gholamreza
G
Amirzadegan
Alireza
A
Saadat
Soheil
S
Abbasi
Seyed Hesameddin
SH
Hamidian
Reza
R
Poorgholi
Leila
L
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015897:Comorbidity; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D044382:Population Groups; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)