title: Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2.
abstract: A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Takeuchi
authors.forename: William G
authors.initials: WG
authors.lastname: Holloway
authors.forename: Charles H
authors.initials: CH
authors.lastname: Mitch
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Quimby
authors.forename: Jamie H
authors.initials: JH
authors.lastname: McKinzie
authors.forename: Todd M
authors.initials: TM
authors.lastname: Suter
authors.forename: Michael A
authors.initials: MA
authors.lastname: Statnick
authors.forename: Peggy L
authors.initials: PL
authors.lastname: Surface
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Emmerson
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Thomas
authors.forename: Miles G
authors.initials: MG
authors.lastname: Siegel
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000180:Acrylic Resins; D000577:Amides; D002264:Carboxylic Acids; D004987:Ethers; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; C030312:calcium polycarbophil