[Molecular mechanism of vitamin K and its regulators in bone metabolism].
Two pathways that mediate vitamin K (VK) action in the bone metabolism have been identified. One pathway is well known mechanism, that mediates the posttranslational modification of the target proteins by VK dependent gamma-carboxylase (GGCX). The other pathway is a novel one, that mediates the transcriptional regulation of the target genes by SXR, steroid and xenobiotic receptor. Both mechanisms of VK are involved in modulation of extracellular matrix proteins in the bone.
Tsukui
Tohru
T
Saitama Medical University, Research Center for Genomic Medicine.
Imazawa
Yukiko
Y
Inoue
Satoshi
S
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D019735:Carbon-Carbon Ligases / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D000077297:Pregnane X Receptor; D011499:Protein Processing, Post-Translational / Q000235:genetics; D011987:Receptors, Steroid / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics; D014812:Vitamin K / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid; D014812:Vitamin K; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase