Social phobia is associated with suicide attempt history in bipolar inpatients.
OBJECTIVE
In an attempt to reduce the phenotypical heterogeneity in an ongoing genetic study of suicidal behavior, we investigated the impact of comorbid anxiety disorders on suicidal behavior in bipolar disorder (BD) patients.


METHODS
Anxiety disorders were compared in 406 BD I and BD II patients with or without lifetime history of suicide attempt.


RESULTS
Among anxiety disorders, only social phobia (SP) was significantly associated with history of suicide attempt in BD [p<0.001, odds ratio 4.26 (2.284-7.946)]. Moreover, onset of SP was found to precede onset of BD.


CONCLUSIONS
This result suggests that SP is an important risk factor for suicidal behavior in BD. Further studies are required to determine whether comorbid SP may help to identify a more homogeneous BD sub-group, especially when studies of suicidal behavior are conducted. A second question is whether SP identifies a sub-group of subjects with BD who have a more severe illness course and whether treatment of SP with selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with improvement or worsening of the course of BD.
Perroud
Nader
N
Department of Psychiatry, University Hospital of Geneva, Chêne-Bourg, Geneva, Switzerland.
Baud
Patrick
P
Preisig
Martin
M
Etain
Bruno
B
Bellivier
Franck
F
Favre
Sophie
S
Reber
Nadja
N
Ferrero
François
F
Leboyer
Marion
M
Malafosse
Alain
A
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010698:Phobic Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*
D017367:Selective Serotonin Reuptake Inhibitors