Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
Montesinos-Rongen
M
M
Department of Neuropathology, University Hospital of Cologne, Cologne, Germany.
Brunn
A
A
Bentink
S
S
Basso
K
K
Lim
W K
WK
Klapper
W
W
Schaller
C
C
Reifenberger
G
G
Rubenstein
J
J
Wiestler
O D
OD
Spang
R
R
Dalla-Favera
R
R
Siebert
R
R
Deckert
M
M
D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D018858:Germinal Center / Q000473:pathology*; D006801:Humans; D007121:Immunocompetence; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged