title: Heteroaryl-substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidine derivatives as potent and selective corticotropin-releasing factor receptor-1 antagonists.
authors.affiliation: Department of Medicinal Chemistry, Psychiatry Centre of Excellence for Drug Discovery (CEDD), Medicines Research Centre, GlaxoSmithKline SpA, Via A. Fleming 4, 37135 Verona, Italy. fabio.m.sabbatini@GSK.com
authors.forename: Fabio Maria
authors.initials: FM
authors.lastname: Sabbatini
authors.forename: Romano
authors.initials: R
authors.lastname: Di Fabio
authors.forename: Yves
authors.initials: Y
authors.lastname: St-Denis
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Capelli
authors.forename: Emiliano
authors.initials: E
authors.lastname: Castiglioni
authors.forename: Stefania
authors.initials: S
authors.lastname: Contini
authors.forename: Daniele
authors.initials: D
authors.lastname: Donati
authors.forename: Elettra
authors.initials: E
authors.lastname: Fazzolari
authors.forename: Gabriella
authors.initials: G
authors.lastname: Gentile
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Micheli
authors.forename: Francesca
authors.initials: F
authors.lastname: Pavone
authors.forename: Marilisa
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pasquarello
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Zampori
authors.forename: Pina
authors.initials: P
authors.lastname: Di Felice
authors.forename: Paola
authors.initials: P
authors.lastname: Zarantonello
authors.forename: Roberto
authors.initials: R
authors.lastname: Arban
authors.forename: Benedetta
authors.initials: B
authors.lastname: Perini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitulli
authors.forename: Roberto
authors.initials: R
authors.lastname: Benedetti
authors.forename: Beatrice
authors.initials: B
authors.lastname: Oliosi
authors.forename: Angela
authors.initials: A
authors.lastname: Worby
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000473:pathology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D015195:Drug Design; D008956:Models, Chemical; D011720:Pyrazoles / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D000099052:CRF Receptor, Type 1
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1; D003346:Corticotropin-Releasing Hormone