Interleukin-23 and TH17 cells in transplantation immunity: does 23+17 equal rejection?
Interleukin-23 (IL-23) and the recently discovered Th17 cells have been implicated in the pathogenesis of autoimmune diseases. This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th17 cells in allograft rejection, tolerance, and ischemia reperfusion injury.
Chen
Ye
Y
Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford, UK. ye.chen@nds.ox.ac.uk
Wood
Kathryn J
KJ
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology*; D053759:Interleukin-23 / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014181:Transplantation Immunology
D020381:Interleukin-17; D053759:Interleukin-23; D007371:Interferon-gamma