[Interferon-stimulating activity of muramoyl dipeptide glycosides].
The uninvestigated interferon (IFN)-inducing capacity of glycoside derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) has been studied. Most MDP glycosides tested in vitro were more active than the reference preparation MDP. Under the in vivo conditions three studied preparations: MDP, a-heptyl-MDP and beta-(2-methyl-3-phenylchromonyl-7)-MDP stimulated production of considerable amount of circulating IFN that evidences for the promising character of their further investigation as preparations immunostimulators.
Zholobak
N M
NM
Spivak
N Ia
NIa
Zemliakov
A E
AE
Tsikalov
V V
VV
Chupakhina
T A
TA
Kur'ianov
V O
VO
Chirva
V Ia
VIa
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000737:chemistry / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D006027:Glycosides; D007369:Interferon Inducers; D010835:Phytohemagglutinins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007372:Interferons