title: Vogt-Koyanagi-Harada syndrome in two patients with immunoglobulin A nephropathy.
abstract: We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-year-old man with a 5-year history of IgA nephropathy developed Vogt-Koyanagi-Harada syndrome. At the time of the eye disease presentation, IgA nephropathy was stable without corticosteroids in both patients. Vogt-Koyanagi-Harada syndrome was successfully treated with intravenous administration of prednisolone tapered from 200 mg daily. Vogt-Koyanagi-Harada syndrome is associated with IgA nephropathy, suggesting a similar autoimmune mechanism for both diseases.
authors.affiliation: Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. matsuot@cc.okayama-u.ac.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsuo
authors.forename: Ikuya
authors.initials: I
authors.lastname: Masuda
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ota
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamadori
authors.forename: Reiko
authors.initials: R
authors.lastname: Sunami
authors.forename: Soichiro
authors.initials: S
authors.lastname: Nose
mesh_terms: D005922:Glomerulonephritis, IGA / Q000150:complications*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone