title: Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".
abstract: Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein-coupled receptor for abscisic acid. We argue that GCR2 is not likely to be a transmembrane protein nor a G protein-coupled receptor. Instead, GCR2 is most likely a plant homolog of bacterial lanthionine synthetases.
authors.affiliation: Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Johnston
authors.forename: Brenda R
authors.initials: BR
authors.lastname: Temple
authors.forename: Jin-Gui
authors.initials: JG
authors.lastname: Chen
authors.forename: Yajun
authors.initials: Y
authors.lastname: Gao
authors.forename: Etsuko N
authors.initials: EN
authors.lastname: Moriyama
authors.forename: Alan M
authors.initials: AM
authors.lastname: Jones
authors.forename: David P
authors.initials: DP
authors.lastname: Siderovski
authors.forename: Francis S
authors.initials: FS
authors.lastname: Willard
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D000465:Algorithms; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000737:chemistry / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D044385:GTP-Binding Protein alpha Subunits / Q000378:metabolism; D006836:Hydro-Lyases / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D010937:Plant Growth Regulators / Q000378:metabolism*; D011485:Protein Binding; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: D029681:Arabidopsis Proteins; C518578:GCR2 protein, Arabidopsis; C429765:GPA1 protein, Arabidopsis; D044385:GTP-Binding Protein alpha Subunits; D009097:Multienzyme Complexes; D010937:Plant Growth Regulators; D043562:Receptors, G-Protein-Coupled; D011994:Recombinant Proteins; D000040:Abscisic Acid; D006836:Hydro-Lyases; C099654:lanthionine synthase