[Chronic lymphocytic leukaemia associated with polycythemia vera].
Simultaneous or sequentional but spontaneous occurzence of polycythaemia vera and chronic lymphocytic leukaemia is very unusual. Moreover, the pathogenesis of these two malignancies has not yet been explained. The authors discribed a 64-year-old man with remarkable mild clinical course of polycytheameia vera associated with chronic lymphocytic leukaemia, lasting more than 5 years. Bone-marrow cell culture revealed spontaneous growth of erythroblast progenitors (BFU-E, CFU-E) and reduced number of haemopoietic progenitorus, mainly due to lymphocyte bone marrow infiltration. The patient plasma selectively inhibited growth of the BFU-E and CFU-E progenitor cells of normal bone-marrow, suggesting that some inhibitor of erythrocytopoiesis influenced supression and/or control of one disease by the other.
Marisavljević
D
D
Radosević-Radojković
N
N
Basara
B
B
Gotić
M
M
Rolović
Z
Z
D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000097:blood / Q000150:complications*