Arrhythmogenesis research: a perspective from computational electrophysiology viewpoint.
The mechanisms by which arrhythmias are generated in the heart remains a field of intensive research. Recent advances in computational biology and electrophysiology have enabled researchers to use an alternative tool in the study of arrhythmia mechanisms, the multi-scale modeling and simulation of cardiac arrhythmogenesis at the organ level. This article reviews the recent advances and achievements using this approach.
Trayanova
Natalia
N
Johns Hopkins University, Baltimore, MD, USA.
Plank
Gernot
G
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D054849:Cardiac Electrophysiology; D019295:Computational Biology / Q000379:methods; D006321:Heart / Q000033:anatomy & histology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular; D011817:Rabbits