[Synergistic effect of Chinese materia medica and chemotherapeutic agents].
Both in vitro and in vitro studies have proved that partial of Chinese materia medica including monomer or active ingredients have synergistic action with chemotherapeutic agents, the former could enhance the effect of the latter. Its mechanism may be correlated with the actions of Chinese materia medica in enhancing immune function, directly killing tumor cells, inducing tumor cell apoptosis, regulating cell cycle and reversing chemotherapeutic drug resistance, etc. The present article summarized the synergistic effect of Chinese materia medica, monomer or active ingredients, with various chemotherapeutic agents, and tried to provide a theoretical evidence for combined application of them in the procedure of clinical tumor treatment.
Zhang
Wei
W
Department of Oncology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing.
Qian
Xiao-ping
XP
Liu
Bao-rui
BR
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D055048:Integrative Medicine / Q000379:methods
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal