title: Sticky platelet syndrome and anterior ischaemic optic neuropathy.
abstract: We report a young patient who presented with nonarteritic anterior ischaemic optic neuropathy associated with the sticky platelet syndrome (SPS, a congenital prothrombotic disorder). A 15-year-old boy presented with a sudden, painless onset of a right inferior altitudinal visual field defect and marked optic disc oedema. Cranial magnetic resonance imaging (including orbits), orbital ultrasound and haematological investigations including a routine hypercoagulability work-up were negative. Further evaluation showed a positive assay for SPS which was confirmed on repeat testing. The SPS (characterized by platelet hyperaggregability and vascular occlusion) may be a potential thrombophilic risk factor for nonarteritic anterior ischaemic optic neuropathy.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Randhawa
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Van Stavern
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D010974:Platelet Aggregation; D013577:Syndrome; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014794:Visual Fields
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin