title: Nonequilibrium fluctuations and mechanochemical couplings of a molecular motor.
abstract: We investigate theoretically the violations of Einstein and Onsager relations and the thermodynamic efficiency for a single processive motor operating far from equilibrium using an extension of the two-state model introduced by Kafri et al. [Biophys. J. 86, 3373 (2004)10.1529/biophysj.103.036152]. With the aid of the Fluctuation Theorem, we analyze the general features of these violations and this efficiency and link them to mechanochemical couplings of motors. In particular, an analysis of the experimental data of kinesin using our framework leads to interesting predictions that may serve as a guide for future experiments.
authors.affiliation: Department of Physics, Florida Atlantic University, 777 Glade Rd., Boca Raton, Florida 33431, USA.
authors.forename: A W C
authors.initials: AW
authors.lastname: Lau
authors.forename: D
authors.initials: D
authors.lastname: Lacoste
authors.forename: K
authors.initials: K
authors.lastname: Mallick
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000465:Algorithms; D004735:Energy Transfer; D036103:Nanotechnology; D013816:Thermodynamics
chemical_list: D000255:Adenosine Triphosphate