title: The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance.
abstract: Although cocaine dependence remains a significant public health concern, efforts to identify a pharmacotherapy have been unsuccessful. The purpose of this study was to assess the safety, tolerability, and subject-rated effects of intranasal cocaine during maintenance on aripiprazole, a novel antipsychotic with partial agonist activity at monoamine receptors implicated in the effects of cocaine. To this end, eight cocaine dependent subjects were maintained on 10 mg oral aripiprazole and placebo in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine (4, 20, 40, and 60 mg). Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose.
authors.affiliation: Department of Behavioral Science, University of Kentucky Medical Center, Lexington, Kentucky 40536-0086, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Stoops
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Lile
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Lofwall
authors.forename: Craig R
authors.initials: CR
authors.lastname: Rush
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology / Q000523:psychology* / Q000534:rehabilitation*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D011795:Surveys and Questionnaires
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D003042:Cocaine