title: Influence of extravascular lung water on transpulmonary thermodilution-derived cardiac output measurement.
abstract: OBJECTIVE
  The transpulmonary thermo-dye dilution technique enables assessment of cardiac index (CI) intrathoracic blood volume index (ITBVI) and extravascular lung water index (EVLWI). Since the extent of lung edema may influence the reliability of CI measurement by transpulmonary thermodilution due to loss of indicator, we analyzed the impact of EVLWI on transpulmonary thermodilution-derived CI in critically ill patients.
  
  
  METHODS
  Retrospective, clinical study.
  
  
  METHODS
  Surgical intensive care unit in a university hospital
  
  
  METHODS
  With ethics approval we analyzed data from 57 patients (38 men, 19 women; age range 18-79 years) who, for clinical indication, underwent hemodynamic monitoring by transpulmonary thermo-dye dilution and pulmonary artery thermodilution (572 measurements). All patients were mechanically ventilated and had received a femoral artery thermo-fiberoptic and pulmonary artery catheter which were connected to a computer system (Cold-Z021, Pulsion Medical Systems, Munich, Germany). For each measurement, 15-17 ml indocyanine green(4-6 degrees C) was injected central venously. Injections were made manually and independently from the respiratory cycle. Linear regression was used for statistical analysis.
  
  
  RESULTS
  The difference between transpulmonary and pulmonary artery thermodilution CI was not correlated with EVLWIfor all measurements (n=572, r=0.01, p=0.76) and when using only the first simultaneous measurement (n=57, r=0.08, p=0.56). Furthermore, EVLWI was not correlated with transpulmonary thermodilution CI (n=572, r=0.07, p=0.08). Coefficient of variation for transpulmonary thermodilution CI was 7.7+/-4.3%.
  
  
  CONCLUSIONS
  Measurement of cardiac output by transpulmonary thermodilution is not influenced by EVLWI in critically ill patients and loss of indicator as the underlying reason is probably overestimated.
authors.affiliation: Friedrich Schiller University of Jena, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pohl
authors.forename: Jan
authors.initials: J
authors.lastname: Kozieras
authors.forename: Samir G
authors.initials: SG
authors.lastname: Sakka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D004396:Coloring Agents; D016638:Critical Illness; D004395:Dye Dilution Technique; D015633:Extravascular Lung Water / Q000502:physiology*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D007275:Injections, Intravenous; D007362:Intensive Care Units; D016014:Linear Models; D008168:Lung / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000503:physiopathology; D015203:Reproducibility of Results; D012121:Respiration, Artificial; D012189:Retrospective Studies; D013815:Thermodilution / Q000379:methods
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green