Recent advances in the synthesis of marine polycyclic ether natural products.
For more than twenty years, chemists and biologists have been fascinated by the highly complex molecular architectures and the diverse and potent biological activities of marine polycyclic ether natural products. Given the scarce availability of these intriguing substances from natural sources, total chemical synthesis is the only way to obtain sufficient quantities for biological investigation. This review describes recent synthetic advances in the field of marine polycyclic ether natural products and their successful implementation in total synthesis endeavors.
Fuwa
Haruhiko
H
Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan. hfuwa@bios.tohoku.ac.jp
Sasaki
Makoto
M
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002922:Ciguatoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D008386:Marine Biology / Q000379:methods; D008387:Marine Toxins / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D035964:Oxocins / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends; D000095702:Polyether Toxins
D001688:Biological Products; D002922:Ciguatoxins; D004988:Ethers, Cyclic; D008387:Marine Toxins; D035964:Oxocins; D011083:Polycyclic Compounds; C053342:brevetoxin; D000095702:Polyether Toxins