title: Room temperature vulcanizing silicone sheaths on a reusable support for progesterone delivery in estrous synchronization treatments in cattle.
abstract: High temperature vulcanizing silicone elastomers have been widely used in controlled delivery systems of steroid hormones with the aim of controlling estrous cycle in livestock. This paper reports experiments conducted to evaluate the possibility of using room temperature vulcanizing (RTV) silicone elastomers for the intravaginal administration of progesterone to cattle. In vitro studies showed that RTV silicones and high-temperature vulcanizing silicone release progesterone at a similar rate. Y-shaped inserts made of different polymers were designed as supports of RTV silicone sheaths to test the in vivo release of progesterone. Field evaluation showed that RTV silicone sheaths containing 0.75 g of progesterone were at least as effective at estrous synchronization as commercially available intravaginal inserts.
authors.affiliation: Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR), Agencia Córdoba Ciencia S.E., Pabellón CEPROCOR, CP 5164, Santa María de Punilla, Córdoba, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Heredia
authors.forename: I D
authors.initials: ID
authors.lastname: Bianco
authors.forename: H
authors.initials: H
authors.lastname: Tríbulo
authors.forename: G
authors.initials: G
authors.lastname: Cuesta
authors.forename: P
authors.initials: P
authors.lastname: Chesta
authors.forename: G A
authors.initials: GA
authors.lastname: Bó
authors.forename: R
authors.initials: R
authors.lastname: Tríbulo
authors.forename: V I
authors.initials: VI
authors.lastname: Mega
authors.forename: D M
authors.initials: DM
authors.lastname: Beltramo
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle / Q000502:physiology*; D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D016503:Drug Delivery Systems / Q000379:methods / Q000662:veterinary*; D004973:Estrus Synchronization / Q000379:methods*; D005260:Female; D008297:Male; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood; D011897:Random Allocation
chemical_list: D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D011374:Progesterone