Measured and expected resting energy expenditure in patients with bipolar disorder on maintenance treatment.
OBJECTIVE
Patients with bipolar disorder (BD) on long-term maintenance treatment represent a clinical population with peculiar characteristics, for which available equations to estimate resting energy expenditure (REE) are not suitable. The aim of this study was to measure REE by means of indirect calorimetry in bipolar patients on maintenance treatment and in controls, and to estimate the agreement between measured and predicted REE in both groups.


METHODS
Patients diagnosed with BD I and healthy controls were assessed for height, weight and body mass index (BMI). Predicted REE was calculated using Harris-Benedict, Schofield, Recommended Nutrients Assumption Levels (LARN), and OUR equations; measurements of REE were performed using a portable indirect calorimeter.


RESULTS
Results for our sample show the most commonly used formulas give a systematic overestimation of REE with respect to measured basal metabolic rate in the patient group. The mean bias was considerably greater for bipolar subjects than for controls.


CONCLUSIONS
These results suggest that patients with severe mental illness on long-term psychopharmacologic treatment may have reduced basal energy expenditure that may be a cause of weight gain.
Soreca
Isabella
I
Department of Neuroscience, Psychiatry Unit, University of Siena, Siena, Italy.
Mauri
Mauro
M
Castrogiovanni
Silvia
S
Simoncini
Marly
M
Cassano
Giovanni B
GB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000465:Algorithms; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001481:Basal Metabolism / Q000502:physiology; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000517:prevention & control*; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002153:Calorimetry, Indirect / Q000706:statistics & numerical data; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009752:Nutritional Status / Q000502:physiology; D000077152:Olanzapine; D012146:Rest / Q000502:physiology*; D012737:Sex Factors
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine