Pentaketides relating to aspinonene and dihydroaspyrone from a marine-derived fungus, Aspergillus ostianus.
Three new pentaketides, aspinotriols A ( 1) and B ( 3) and aspinonediol ( 5), were isolated together with two known compounds, aspinonene ( 7) and dihydroaspyrone ( 9), from the marine fungus Aspergillus ostianus strain 01F313, which was collected in Pohnpei and cultured with bromine-modified artificial seawater. The structures of the new compounds were determined by spectroscopic analyses including 1D and 2D NMR. Although 1 and 3 are diastereomers, they show nearly superimposable (1)H and (13)C NMR spectra. The absolute configurations of compounds 1, 3, 5, and 9 were elucidated by the modified Mosher's method.
Kito
Keijiro
K
Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.
Ookura
Ryuhei
R
Yoshida
Sanae
S
Namikoshi
Michio
M
Ooi
Takashi
T
Kusumi
Takenori
T
D001230:Aspergillus / Q000737:chemistry*; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification
D011090:Polyenes; D011753:Pyrones; C097479:aspyrone