FeCl3-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes.
An efficient FeCl3-catalyzed substitution reaction of propargylic acetates with enoxysilanes under mild conditions to afford corresponding gamma-alkynyl ketones has been developed. The substitution reaction is followed by a TsOH-catalyzed cyclization without purification of the gamma-alkynyl ketone intermediates, offering a straightforward synthetic route to tri- or tetrasubstituted furans.
Zhan
Zhuang-ping
ZP
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, People's Republic of China. zpzhan@xmu.edu.cn
Cai
Xu-bin
XB
Wang
Shao-pei
SP
Yu
Jing-liang
JL
Liu
Hui-juan
HJ
Cui
Yuan-yuan
YY