CD4+/CD56+ hematodermic neoplasm: blastic NK cell lymphoma in a 6-year-old child: report of a case and review of literature.
A 6-year-old girl presented with disseminated polymorphous skin lesions of several months' duration, joint pains, recurrent fever, anemia, and inguinal adenopathy. Subsequent evaluation of skin, lymph node, and bone marrow morphology showed infiltration of atypical lymphocytic cells. Immunohistochemical and flow cytometric analysis showed findings consistent with the rare but highly malignant blastic Natural killer cell lymphoma/leukemia also termed CD4/CD56 hematodermic neoplasm.
Eguaras
Ann Veronique C
AV
Department of Pediatrics, Section of Hematology-Oncology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Lo
Raymundo W
RW
Veloso
Januario D
JD
Tan
Vivian Grace
VG
Enriquez
Ma Luisa D
ML
Del Rosario
Ma Luz U
ML
D015704:CD4 Antigens / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
D015704:CD4 Antigens; D019002:CD56 Antigen