title: Use of elevated flow rates in preparative subcritical fluid chromatography.
abstract: The benefits of using high flow rates in preparative subcritical fluid chromatography are explored. It is demonstrated that chromatograms loaded to onset of peak coalescence do not deteriorate as flow increases. This allows separation of material in very short time periods leading to dramatically increased production rates. A key factor to accessing elevated flows is the use of shorter columns and the resulting decrease in pressure drop.
authors.affiliation: Thar Instruments, Newark, DE, USA. rstringham@clintonfoundation.org
authors.forename: Rodger W
authors.initials: RW
authors.lastname: Stringham
authors.forename: Brian R
authors.initials: BR
authors.lastname: Krueger
authors.forename: Jonathan
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000082:Acetaminophen / Q000302:isolation & purification; D000983:Antipyrine / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000379:methods*; D011725:Pyridines
chemical_list: D011725:Pyridines; D000082:Acetaminophen; D000983:Antipyrine