title: Serotonin-1A receptors in frontotemporal dementia compared with controls.
abstract: Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT(1A) binding potential (BP) compared with controls in all 10 brain regions examined. These pilot data suggest that profound 5-HT(1A) BP losses may be present and contribute to symptomatology and treatment response in FTLD.
authors.affiliation: Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. krista.lanctot@sunnybrook.ca
authors.forename: Krista L
authors.initials: KL
authors.lastname: Lanctôt
authors.forename: Nathan
authors.initials: N
authors.lastname: Herrmann
authors.forename: Hooman
authors.initials: H
authors.lastname: Ganjavi
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Black
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Rusjan
authors.forename: Sylvain
authors.initials: S
authors.lastname: Houle
authors.forename: Alan A
authors.initials: AA
authors.lastname: Wilson
mesh_terms: D000368:Aged; D001665:Binding Sites; D003704:Dementia / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*
chemical_list: D044282:Receptor, Serotonin, 5-HT1A