AP-1 a target for cancer prevention.
The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.
Matthews
Connie P
CP
Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
Colburn
Nancy H
NH
Young
Matthew R
MR
D002471:Cell Transformation, Neoplastic; D018890:Chemoprevention; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009369:Neoplasms / Q000517:prevention & control*; D018808:Transcription Factor AP-1 / Q000502:physiology*
D018808:Transcription Factor AP-1