A dynamical model on the network of p53-Mdm2 feedback loop regulated by p14/19ARF.
Base on new experimental results, we give a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARF. The oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors among p53, Mdm2 and P14/19ARF. The dynamical model and its numerical results will help us understand the oscillatory behavior among other network of different proteins.
Liu
Hui
H
School of Science, Hebei University of Technology, Tianjin, China. lhcell@163.com
Han
Ying-Rong
YR
Zhan
Yong
Y
Chen
Ya-Fei
YF
Zhang
Yu-Hong
YH
Yu
Hui
H
Zhao
Tong-Jun
TJ
Zhuo
Yi-Zhong
YZ
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2