Role of low-dose, noncontrast computed tomography from integrated positron emission tomography/computed tomography in evaluating incidental 2-deoxy-2-[F-18]fluoro-D-glucose-avid colon lesions.
OBJECTIVE
To assess the contribution of concurrent low-dose, noncontrast CT in the assessment of the malignant potential of incidental focal 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-avid colonic lesions on positron emission tomography/computed tomography (PET/CT).


METHODS
Routine FDG-PET/CT scans were reviewed for identification of focal FDG-avid colon lesions, and the CT component was independently reviewed for an anatomical lesion and malignant potential based on CT criteria. Clinical, endoscopic, and histopathology follow-up was obtained.


RESULTS
A total of 85/2,916 (3%) oncology FDG-PET/CT scans had incidental focal colon lesions. Clinical and/or endoscopic follow-up was available in 83/85 (98%) patients. Focal, corresponding CT lesions were found in 44/83 (53%) patients, but features of malignancy were not assessable. Of the 44 patients with a final diagnosis, 32/44 (73%) were FDG-PET/CT true positives; 5/44 (11%) were false positives; and 7/44 (16%) had inconclusive FDG-PET/CT findings.


CONCLUSIONS
Concurrent low-dose, noncontrast CT improves localization, but does not provide independent information on the malignant potential of incidental focal colonic activity on FDG-PET/CT.
Lee
S T
ST
Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia. szeting.lee@auston.org.au
Tan
T
T
Poon
A M T
AM
Toh
H B
HB
Gill
S
S
Berlangieri
S U
SU
Kraft
E
E
Byrne
A J
AJ
Pathmaraj
K
K
O'Keefe
G J
GJ
Tebbutt
N
N
Scott
A M
AM
D003108:Colonic Diseases / Q000175:diagnosis*; D003287:Contrast Media / Q000378:metabolism*; D004724:Endoscopy; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D019788:Fluorodeoxyglucose F18