Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.
We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.
Sung
Young H
YH
Department of Neurology, Gachon University College of Medicine, Incheon, Korea.
Chung
Sun J
SJ
Kim
Sung R
SR
Lee
Myoung C
MC
D000368:Aged; D003710:Demography; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005121:Extremities / Q000503:physiopathology; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011187:Posture; D011446:Prospective Studies; D012146:Rest; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014202:Tremor / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology
D018491:Dopamine Agonists; D007980:Levodopa