Evidence of brain mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy at 3T.
The purpose of this study was to explore mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy. Six healthy volunteers were studied using a GE 3T scanner. A spin-echo MRS sequence was utilized with a GE service coil. TR was 2000 msec and TE 35 msec with 128 scan averages. Before 31P scan, a 1H MRS pre-scan was performed to obtain shimming values. Exact two 31P scans were performed before and after oxygen inhalation through nasal cannula at a flow rate of 10 L/min. Data were processed offline using the SAGE/IDL software. Peak integral values of inorganic phosphor, phosphocreatine, and ATPs were measured. Peak integral values of inorganic phosphor were decreased from 1.44% to 16.62% (mean+/-SD, 8.2+/-4.60). Peak integral values of phosphocreatine were increased from 1.06% to 8.64% (4.54+/-2.74). Peak integral values of gammaATP were increased from 0.75% to 15.97% (5.94+/-6.10); alphaATP from 1.21% to 16.05% (7.04+/-6.14); betaATP from 1.01% to 7.12% (3.08+/-2.30). Brain mitochondrial activities were increased and more ATPs were produced after oxygen inhalation in healthy volunteers.
Wu
Ren-Hua
RH
Department of Medical Imaging, Shantou University Medical College, China. rhwu@stu.edu.cn
Poublanc
Julien
J
Mandell
Danny
D
Detzler
Garry
G
Crawley
Adrian
A
Qiu
Qing-Chun
QC
terBrugge
Karel
K
Mikulis
David J
DJ
D000255:Adenosine Triphosphate / Q000378:metabolism; D000280:Administration, Inhalation; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000031:analogs & derivatives / Q000378:metabolism; D010759:Phosphorus Isotopes
D010759:Phosphorus Isotopes; D010725:Phosphocreatine; C025403:phosphocreatinine; D000255:Adenosine Triphosphate; D010100:Oxygen