title: Loss of ethanol from vitreous humor in drowning death.
abstract: Two separate cases of drowning with extended periods underwater (2 and 4 weeks) are reported. The postmortem ethanol concentrations were 260 and 280 in central blood, 50 and 80 in vitreous, and 330 and 320 in urine (mg/100 mL) for cases 1 and 2, respectively. Determination of the urine 5-hydroxytryptophol/5-hydroxyindole-3-acetic acid ratios produced results of 713 and 41 pmol/nmol, respectively. The serotonin metabolite ratios support the explanation of diffusion of ethanol from the vitreous fluid into the surrounding water, rather than postmortem production of ethanol in blood, as the primary reason for the blood-vitreous ethanol differences.
authors.affiliation: Office of Chief Medical Examiner, 7007 - 116 Street, Edmonton, Alberta, Canada T6H 5R8.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Singer
authors.forename: Graham R
authors.initials: GR
authors.lastname: Jones
authors.forename: Russell
authors.initials: R
authors.lastname: Lewis
authors.forename: Robert
authors.initials: R
authors.lastname: Johnson
mesh_terms: D000328:Adult; D002423:Cause of Death; D004058:Diffusion; D004332:Drowning; D000431:Ethanol / Q000032:analysis / Q000378:metabolism*; D017809:Fatal Outcome; D053593:Forensic Toxicology / Q000379:methods*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D006917:Hydroxytryptophol / Q000652:urine; D008297:Male; D011180:Postmortem Changes; D014822:Vitreous Body / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006917:Hydroxytryptophol; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid