Advanced pediatric inoperable thymus carcinoma (type C thymoma): case report on a novel therapeutic approach.
Although there has been considerable advancement in treatment techniques but still there are some illnesses that continue to exhibit a rather poor curability, such as thymoma. This report highlights the benefit of octreotide and prednisolone therapy in a 15-year-old girl, who was diagnosed with inoperable thymus carcinoma, with chemotherapy and radiotherapy being the last resort. The detection of type 2 somatostatin receptors on the surface of the tumor justified the introduction of treatment with somatostatin analog and prednisolone. Fortunately, after 6 months of this treatment, the tumor showed partial regression. However, 2 months later, somatostatin receptor negative metastases appeared; therefore, a switch over to imatinib became essential, because the tumor was CD-117 positive. Despite the therapy change, the patient's condition deteriorated owing to tumor progression.
Kertesz
Gabriella P
GP
2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary. gkertesz@yahoo.com
Hauser
Peter
P
Varga
Peter
P
Dabasi
Gabriella
G
Schuler
Dezso
D
Garami
Miklos
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D013945:Thymoma / Q000175:diagnosis / Q000188:drug therapy*; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D011239:Prednisolone; D015282:Octreotide