title: Cooperation of translocase complexes in mitochondrial protein import.
abstract: Most mitochondrial proteins are synthesized in the cytosol and imported into one of the four mitochondrial compartments: outer membrane, intermembrane space, inner membrane, and matrix. Each compartment contains protein complexes that interact with precursor proteins and promote their transport. These translocase complexes do not act as independent units but cooperate with each other and further membrane complexes in a dynamic manner. We propose that a regulated coupling of translocases is important for the coordination of preprotein translocation and efficient sorting to intramitochondrial compartments.
authors.affiliation: Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, and 2Fakultät für Biologie, Universität Freiburg, 79104 Freiburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kutik
authors.forename: Bernard
authors.initials: B
authors.lastname: Guiard
authors.forename: Helmut E
authors.initials: HE
authors.lastname: Meyer
authors.forename: Nils
authors.initials: N
authors.lastname: Wiedemann
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Pfanner
mesh_terms: D003600:Cytosol / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism; D021381:Protein Transport
chemical_list: D018840:HSP70 Heat-Shock Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011498:Protein Precursors