title: Social phobia is associated with suicide attempt history in bipolar inpatients.
abstract: OBJECTIVE
  In an attempt to reduce the phenotypical heterogeneity in an ongoing genetic study of suicidal behavior, we investigated the impact of comorbid anxiety disorders on suicidal behavior in bipolar disorder (BD) patients.
  
  
  METHODS
  Anxiety disorders were compared in 406 BD I and BD II patients with or without lifetime history of suicide attempt.
  
  
  RESULTS
  Among anxiety disorders, only social phobia (SP) was significantly associated with history of suicide attempt in BD [p<0.001, odds ratio 4.26 (2.284-7.946)]. Moreover, onset of SP was found to precede onset of BD.
  
  
  CONCLUSIONS
  This result suggests that SP is an important risk factor for suicidal behavior in BD. Further studies are required to determine whether comorbid SP may help to identify a more homogeneous BD sub-group, especially when studies of suicidal behavior are conducted. A second question is whether SP identifies a sub-group of subjects with BD who have a more severe illness course and whether treatment of SP with selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with improvement or worsening of the course of BD.
authors.affiliation: Department of Psychiatry, University Hospital of Geneva, Chêne-Bourg, Geneva, Switzerland.
authors.forename: Nader
authors.initials: N
authors.lastname: Perroud
authors.forename: Patrick
authors.initials: P
authors.lastname: Baud
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
authors.forename: Bruno
authors.initials: B
authors.lastname: Etain
authors.forename: Franck
authors.initials: F
authors.lastname: Bellivier
authors.forename: Sophie
authors.initials: S
authors.lastname: Favre
authors.forename: Nadja
authors.initials: N
authors.lastname: Reber
authors.forename: François
authors.initials: F
authors.lastname: Ferrero
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.forename: Alain
authors.initials: A
authors.lastname: Malafosse
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010698:Phobic Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors