[Significance of endothelin in arterial hypertension in children].
Concentration of plasma endothelin and the activity of Na(+)-K(+)-ATP-ase were determined in 3 different groups of children: the 1st group comprised 13 children with essential hypertension, aged 12.9+/-4.8; the 2nd group concerned 16 children with renal hypertension, but with preserved global renal function, aged 13.7+/-2.8, and the 3rd group consisted of 27 healthy children, aged 11.6+/-6.3 years. Plasma endothelin concentrations were measured by radioimmunological method, using a set manufactured by "Biomedica". The activity of Na(+)-K(+)-ATPase was determined in erythrocyte haemolysate by measuring the quantity of released inorganic phosphate in samples with and without ouabaine. Concentration of plasma endothelin was not significantly different between the children with arterial hypertension and healthy children, and there was no significant correlation between endothelin concentration and blood pressure in either of the 3 groups of children. The activity of Na(+)-K(+)-ATP-ase was significantly decreased only in the 1st group of children. There was no evidence of correlation between the Na(+)-K(+)-ATPase activity and blood pressure or plasma endothelin either in healthy, or in hypertensive children.


CONCLUSIONS
Endothelin in blood circulation has no significance in regulating blood pressure in healthy children. It also has no direct role on the development of essential and renal hypertension in children. The activity of Na(+)-K(+)-ATP-ase is decreased in children with essential hypertension, but it seems that it has no direct impact on hypertension. Endothelin in circulation and Na(+)-K(+)-ATP-ase activity are not interdependant.
Peco-Antić
A
A
Nastić-Mirić
D
D
Topajov
D
D
Popović-Rolović
M
M
Adanja
G
G
Kostić
M
M
Marsenić
O
O
Paripović
V
V
D000293:Adolescent; D002648:Child; D016232:Endothelins / Q000097:blood* / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D016232:Endothelins; D000254:Sodium-Potassium-Exchanging ATPase