title: A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.
abstract: Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Choi
authors.forename: Katie J
authors.initials: KJ
authors.lastname: Stanton-Maxey
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Stanley
authors.forename: Carly S
authors.initials: CS
authors.lastname: Levin
authors.forename: Rizia
authors.initials: R
authors.lastname: Bardhan
authors.forename: Demir
authors.initials: D
authors.lastname: Akin
authors.forename: Sunil
authors.initials: S
authors.lastname: Badve
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sturgis
authors.forename: J Paul
authors.initials: JP
authors.lastname: Robinson
authors.forename: Rashid
authors.initials: R
authors.lastname: Bashir
authors.forename: Naomi J
authors.initials: NJ
authors.lastname: Halas
authors.forename: Susan E
authors.initials: SE
authors.lastname: Clare
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001692:Biological Transport; D015687:Cell Hypoxia; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000648:ultrastructure; D009000:Monocytes / Q000187:drug effects / Q000648:ultrastructure; D053758:Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D013053:Spectrophotometry
chemical_list: D000970:Antineoplastic Agents