Concurrent validation of the 21-item and 6-item Hamilton Depression Rating Scale versus the DSM-IV diagnostic criteria to assess depression in patients with Parkinson's disease: an exploratory analysis.
OBJECTIVE
The concurrent validity of this 6-item version of Hamilton Depression Rating Scale (HDRS-6) compared to the original 21-item tool (HDRS-21), using the DSM-IV criteria for major depression as the gold standard in patients with Parkinson's disease.


METHODS
In analytical study were analyzed: Cronbach's alpha (alpha C), item-total correlation, the receiver operating characteristic curve (ROC) and their area under the curve (AUC), Finally, used the Fagan nomogram.


RESULTS
The 115-patient sample with mean illness duration of 7.15 years. HDRS-21 achieved an alpha C of 0.83, HDRS-6 a value of 0.68. Eleven of the HDRS-21 items failed to reach a minimum value. HDRS-21 obtained its better AUC capacity of 0.94 (cut/score of 18/19); HDRS-6 got an AUC of 0.92 (cut/score of 7/8). The Fagan nomogram was (89-94% and 83-90%, respectively).


CONCLUSIONS
Our results suggest that HDRS-6 is sufficient, valid and has a sound psychometric structure for use with Parkinson's disease patients.
Serrano-Dueñas
Marcos
M
Abnormal Movement Disorder Clinic, Neurological Service, Hospital Carlos Andrade Marín, Quito, Ecuador. serranom@pi.pro.ec
Soledad Serrano
María
M
D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000175:diagnosis* / Q000209:etiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index