[Relationship between p53 Arg72Pro polymorphism and cervical carcinoma in Uigur and Han women in Xinjiang].
OBJECTIVE
To investigate the association between p53 Arg72Pro polymorphism and cervical carcinomas HPV-associated cervical carcinoma in Uigur and Han women.


METHODS
The distribution and frequencies of p53 Arg72Pro genotypes were determined by PCR-RFLP in 152 cases of cervical carcinoma in ethnic Uigur women with 110 cases of normal control and 120 cases of cervical carcinoma in Han women with 122 cases of normal control.


RESULTS
The omni-constituent ratio of p53 genotype was statistically different between cervical carcinoma and normal control groups in the Uigur (chi(2) = 7.196, P < 0.05) group. The proportion of Arg/Arg was higher in cervical carcinomas than that in control. The omni-constituent ratio of p53 genotype was statistically different between cervical carcinoma and normal control groups in Han (chi(2) = 8.231, P < 0.025). The proportion of Pro/Pro was higher in cervical carcinoma than that in normal control. The omni-constituent ratio was statistically different between HPV 16 positive and negative groups of cervical carcinoma in the Uigur group (chi(2) = 7.177, P < 0.05). The proportion of Arg/Arg was higher in HPV 16 positive group than that in HPV 16 negative group.


CONCLUSIONS
p53 Arg72Pro polymorphism may be associated with the development of cervical carcinoma in Uigur and Han women in Xinjiang. p53 Arg/Arg genotype may be a genetically susceptible factor to HPV-associated cervical carcinoma in Uigur. p53 Pro/Pro genotype may be a genetically susceptible factor to cervical carcinoma in Han. There may be different susceptibilities to cervical cancer between Uigur and Han women in Xinjiang.
Zheng
Xing-zheng
XZ
Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Pathology, Medical School, Shihezi University, Xinjiang 832002, China.
Yang
An-qiang
AQ
Pan
Xiao-lin
XL
Zheng
Li-li
LL
Zhou
Qiu-yuan
QY
Li
Xin-min
XM
Wang
Xiao-ling
XL
Yan
Li-hua
LH
Li
Hong-an
HA
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002681:China / Q000208:ethnology; D003062:Codon; D004273:DNA, Neoplasm / Q000235:genetics; D005091:Exons; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D030361:Papillomavirus Infections / Q000208:ethnology; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000821:virology; D055815:Young Adult
D003062:Codon; D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53