title: The model of Monod, Wyman, and Changeux generates two sets of parameters when applied to oxygen binding in hemoglobin.
abstract: The model of Monod, Wyman and Changeux is applied to binding phenomena where the Mass Law and its expansion are employed. In this communication the model of Monod, Wyman and Changeux (MWC) is applied to analyze the oxygen binding reaction in hemoglobin. The symmetrical structure of the MWC model with its three parameters is such that two sets of these parameters, rather than one, fit experimental data for the binding of oxygen to hemoglobin.
authors.affiliation: The Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. saroff@helix.nih.gov
authors.forename: Harry A
authors.initials: HA
authors.lastname: Saroff
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D006454:Hemoglobins / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D010100:Oxygen / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D006454:Hemoglobins; D010100:Oxygen