title: Parsimonious design principles for motor unit models.
abstract: Motor units are known to display type-specific differences in passive and active electrical properties, and attempts to predict motor unit type based on the measurement of membrane properties have been rather successful. Quantitative models of motoneurons have also grown in complexity and their predictive power is predicated upon the accurate description of basic membrane properties. This paper presents results from a modeling study which sought to specify a small and simple set of "design rules" that motoneurons might obey during type-specific differentiation.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30322 USA. e-mail: gtg117x@mail.gatech.edu.
authors.forename: Lan
authors.initials: L
authors.lastname: Ban
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Shapiro
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D002412:Cations; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism; D003712:Dendrites / Q000473:pathology*; D004867:Equipment Design; D006801:Humans; D008959:Models, Neurological; D015233:Models, Statistical; D008962:Models, Theoretical; D009046:Motor Neurons / Q000473:pathology*; D009068:Movement; D015221:Potassium Channels / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism; D013997:Time Factors
chemical_list: D002412:Cations; D015221:Potassium Channels; D015222:Sodium Channels