Advantages of synthesizing trans-1,2-cyclohexanediol in a continuous flow microreactor over a standard glass apparatus.
Comparison is made between the preparation of trans-1,2-cyclohexanediol in standard glassware (conventional batch production) and in a microreactor (continuous flow production). The reaction sequence involved two exothermic steps where the standard procedure demands slow reagent addition and careful temperature control. In the microreactor, the reaction could be carried out safely with up to 3 times higher reagent concentration. Synthetic benefits were a faster reaction rate and a higher purity product free of colored impurities (a feature of the batch procedure).
Hartung
Andreas
A
Chemistry and Chemical Engineering, School of Engineering & Physical Sciences, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, United Kingdom a.kraft@hw.ac.uk.
Keane
Mark A
MA
Kraft
Arno
A
D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D005898:Glass; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013696:Temperature; D013997:Time Factors
D003511:Cyclohexanols; C064619:1,2-cyclohexanediol