New physiological model of serum creatine phosphokinase activity in acute myocardial infarction. Estimation of the total creatine phosphokinase release.
In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.
Kitawaki
Tomoki
T
Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, Japan. kitawaki@md.okayama-u.ac.jp
Oka
Hisao
H
Kusachi
Shozo
S
Himeno
Ryutaro
R
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003198:Computer Simulation; D003402:Creatine Kinase / Q000097:blood*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers; D003402:Creatine Kinase