Cobalt-catalyzed cross-coupling of alkynyl Grignard reagents with alkenyl triflates.
Alkenyl triflates in combination with Co(acac)(3) as a catalyst were found to be excellent coupling partners of alkynyl Grignard reagents, where no special additives (even a phosphine ligand) but a common solvent, THF, are required to obtain variously substituted enynes.
Shirakawa
Eiji
E
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. shirakawa@kuchem.kyoto-u.ac.jp
Sato
Takahiro
T
Imazaki
Yusuke
Y
Kimura
Takahiro
T
Hayashi
Tamio
T
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D006885:Hydroxybutyrates / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D010422:Pentanones / Q000737:chemistry
D000475:Alkenes; D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D006885:Hydroxybutyrates; D008698:Mesylates; D010422:Pentanones; C049529:acetyl acetonate; D003035:Cobalt; C012077:trifluoromethanesulfonic acid