From therapy to experimental model: a hundred years of endotoxin administration to human subjects.
This article is a review of studies in which endotoxin has been administered to human subjects for experimental purposes. Data are presented in tabular form so the reader can better appreciate the objectives of individual studies. Although the original intention was to focus on the adverse events associated with these studies, unexpected serious adverse events rarely have been reported.
Bahador
Marjan
M
Center for Vaccine Development and Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. mbahador@medicine.umaryland.edu
Cross
Alan S
AS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D001777:Blood Coagulation / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism; D064420:Drug-Related Side Effects and Adverse Reactions; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology; D004731:Endotoxins / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D004731:Endotoxins