Synthesis of some N4-substituted isatin-3-thiosemicarbazones.
In this article, we describe a simple and new method for the synthesis of some N4-substituted isatin-3-thiosemicarbazones based on the reactions of the common intermediate, methyl 2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbodithioate, prepared by condensing isatin with methyl 1-hydrazinecarbodithioate, and the readily available amines in essentially a one-step reaction. The synthesized thiosemicarbazones were fully characterized by their physical, analytical, and spectral (IR, 1H-NMR, EIMS) data.
Pervez
H
H
Department of Chemistry, Bahauddin Zakariya University, Multan, 60800, Pakistan. pdhpervez@hotmail.com
Iqbal
M S
MS
Tahir
M Y
MY
Choudhary
M I
MI
Khan
K M
KM
D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
D013882:Thiosemicarbazones; D007510:Isatin