Disruption of limbic pathways in a case of profound amnesia.
We report a case of episodic amnesia in which the anatomical basis of injury was investigated by diffusion tensor imaging (DTI). Two months after an adult male suffered severe closed head injury, conventional magnetic resonance imaging (CMRI) revealed only a right superior frontal lesion. However, 14 years later, DTI revealed structural anomalies not visible on CMRI involving limbic white matter tracts, notably the fornix, which could explain the amnesia.
Papanicolaou
A C
AC
Department of Pediatrics, University of Texas-Houston Medical School, Houston, TX 77030, USA. Andrew.C.Papanicolaou@uth.tmc.edu
Hasan
K M
KM
Boake
C
C
Eluvathingal
Thomas J
TJ
Kramer
L
L
D000328:Adult; D000647:Amnesia / Q000473:pathology*; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008032:Limbic System / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male