Application of fractal dimension method of functional MRI time-series to limbic dysregulation in anxiety study.
Functional magnetic resonance imaging (fMRI) allows to investigate the amplitude of activation in neural networks of brain. In this work we present the results of fMRI time-series analysis performed to identify the process of dysregulation of dynamic interaction between different limbic system regions in healthy adults in state of increased anxiety. The results obtain for 65 healthy adults using nonlinear dynamics methods like fractal dimension confirm the key roles of the bilateral amygdala, bilateral hippocampus, BA9 (dorsolateral prefrontal cortex), and BA45 (ventromedial prefrontal cortex) in modulating emotional response in healthy adults. For different regions of interest (ROIs) significant correlations were found not only for the neutral respective rest but also for fear and angry contrasts.
Olejarczyk
Elzbieta
E
Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena str., 02-109 Warsaw, Poland. federico@ibib.waw.pl
D000328:Adult; D000465:Algorithms; D001007:Anxiety / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D017709:Fractals; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D008032:Limbic System / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity