[Treatment of non-Hodgkin's lymphomas of medium and high malignancy].
Comparison of therapeutical protocols of three generation: CHOP the first, COP-BLAM and ProMACE-MOPP the second and ProMACE-Cyta BOM the third, was based on treatment od 45 patients with agressive lymphoma in whom these protocols were applies as the primary chemotherapy. In our series of patients and therapeutical conditions the CHOP protocol proves somewhat superior to the second and third generation protocols: persentige of complete remission (CR) was high (64%), mean duration of CR was among longes (12 months), while neither cases of relapse during the monitoring of patients were noted not toxic effects of therapy. The rate of fatal outcomes was among the lowest (36%) and the probability of surviving longer then 16 months was the highest (9.73).
Mihaljević
B
B
Petrović
M
M
Jancić-Nedeljkov
R
R
Jovanović
V
V
Rolović
Z
Z
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged