Linkage disequilibrium mapping for complex disease genes.
In this chapter we lay out some background information about gene mapping for human complex traits. The chapter covers issues such as study design, high-throughput genotyping technologies, statistical analysis, and others. Many of the materials are based on and related to our recent experiences in case-control-association studies.
DeWan
Andrew
A
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
Klein
Robert J
RJ
Hoh
Josephine
J
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D030561:Databases, Nucleic Acid; D004194:Disease; D004843:Epistasis, Genetic; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011786:Quality Control; D017422:Sequence Analysis, DNA