Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training.
Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.
Huang
Hu
H
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Tada Iida
Kaoruko
K
Murakami
Haruka
H
Saito
Yoko
Y
Otsuki
Takeshi
T
Iemitsu
Motoyuki
M
Maeda
Seiji
S
Sone
Hirohito
H
Kuno
Shinya
S
Ajisaka
Ryuichi
R
D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000097:blood / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D001786:Blood Glucose; D002784:Cholesterol; D004247:DNA; D006442:Glycated Hemoglobin; D007328:Insulin; D014280:Triglycerides