title: Memory versus naive T-cell migration.
abstract: Our established understanding of lymphocyte migration suggests that naive and memory T cells travel throughout the body via divergent pathways; naive T cells circulate between blood and lymph whereas memory T cells additionally migrate through non-lymphoid organs. Evidence is now gradually emerging which suggests such disparate pathways between naive and memory T cells may not strictly be true, and that naive T cells gain access to the non-lymphoid environment in numbers approaching that of memory T cells. We discuss here the evidence for naive T-cell traffic into the non-lymphoid environment, compare and contrast this movement with what is known of memory T cells, and finally discuss the functional importance of why naive T cells might access the parenchymal tissues.
authors.affiliation: School of Clinical Veterinary Science, University of Bristol, Langford, Bristol, UK.
authors.forename: Marie
authors.initials: M
authors.lastname: Lewis
authors.forename: John F
authors.initials: JF
authors.lastname: Tarlton
authors.forename: Stephen
authors.initials: S
authors.lastname: Cose
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D016326:Extracellular Matrix Proteins / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000502:physiology; D008221:Lymphoid Tissue / Q000502:physiology; D054400:Receptors, CCR7 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000502:physiology
chemical_list: D016326:Extracellular Matrix Proteins; D054400:Receptors, CCR7