FZD3 is not a risk gene for schizophrenia: a case-control study in a Caucasian sample.
BACKGROUND
Polymorphisms in the human frizzeled-3 (FZD3) gene have been associated with schizophrenia in an Asian population sample. However, this finding could not be confirmed in subsequent studies investigating other populations. Here we attempted to replicate this finding in a sample of 192 German chronically ill schizophrenic subjects.


METHODS
Three single nucleotide polymorphisms in the FZD3 gene have been genotyped by primer extension and MALDI-TOF measurement. Subsequently, associations for single markers as well as haplotypes were tested.


RESULTS
In German patients, neither single markers nor haplotypes in FZD3 were associated with schizophrenia. Further exploratory analyses using a different diagnostic approach did also not yield significant results.


CONCLUSIONS
FZD3 is unlikely to play a role in the genetic predisposition towards schizophrenia in the Caucasian population.
Reif
A
A
Department of Psychiatry and Psychotherapy, Molecular and Clinical Psychobiology, University of Würzburg, Würzburg, Germany. a.reif@gmx.net
Melchers
M
M
Strobel
A
A
Jacob
C P
CP
Herterich
S
S
Lesch
K P
KP
Zimmer
M
M
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D051157:Frizzled Receptors / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005858:Germany; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
C105574:FZD3 protein, human; D051157:Frizzled Receptors; D005819:Genetic Markers; D043562:Receptors, G-Protein-Coupled