title: A blinded randomized controlled trial evaluating the usefulness of a novel diet (aminoprotect care) in dogs with spontaneous food allergy.
abstract: Aminoprotect Care (APC) is a novel diet composed of aminoacids, potato proteins and corn starch. The objectives of this study were to determine whether Maltese-Beagle atopic (MBA) dogs hypersensitive to corn exhibited clinical signs and changes in immunological markers after being fed APC. The study was designed as a blinded randomized controlled crossover experiment. Ten MBA dogs with signs of allergy within five days of ingesting corn were selected. Dogs were randomized to be fed either their maintenance diet with corn or APC for five days. After a washout of two weeks, diets were switched. Before and daily during each intervention, skin lesions were graded by an investigator while pruritus was assessed by another. Before and at the end of each intervention, the percentage of circulating CD4+CCR4+, corn-activated CD4+ T-lymphocytes and serum corn-specific IgE levels were measured and ratios of post:pre values calculated. During this trial, pruritus and skin lesions increased significantly in MBA dogs when ingesting corn while no such increase occurred when fed APC. Total, median and maximal pruritus values were significantly higher in MBA dogs ingesting corn compared to APC. There were no significant differences between interventions in the immunological parameters assessed. In summary, even though APC contains corn starch to which corn-sensitive MBA dogs often react, the ingestion of APC did not lead to significant increases in skin lesions or pruritus. Aminoprotect Care might prove valuable for management of food allergies. These experimental observations must be validated in large field studies.
authors.affiliation: Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA. Thierry_Olivry@ncsu.edu
authors.forename: Thierry
authors.initials: T
authors.lastname: Olivry
authors.forename: Keigo
authors.initials: K
authors.lastname: Kurata
authors.forename: Judy S
authors.initials: JS
authors.lastname: Paps
authors.forename: Kenichi
authors.initials: K
authors.lastname: Masuda
mesh_terms: D000821:Animal Feed; D000818:Animals; D018592:Cross-Over Studies; D004032:Diet / Q000662:veterinary*; D004283:Dog Diseases / Q000178:diet therapy*; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000628:therapy / Q000662:veterinary*; D008213:Lymphocyte Activation; D008297:Male; D011537:Pruritus; D012871:Skin Diseases; D006377:T-Lymphocytes, Helper-Inducer; D003313:Zea mays