title: Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
abstract: A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
authors.affiliation: Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 5400, Princeton, NJ 08543, USA. jun.li@bms.com
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Stephanie Y
authors.initials: SY
authors.lastname: Chen
authors.forename: James J
authors.initials: JJ
authors.lastname: Li
authors.forename: Haixia
authors.initials: H
authors.lastname: Wang
authors.forename: Andres S
authors.initials: AS
authors.lastname: Hernandez
authors.forename: Shiwei
authors.initials: S
authors.lastname: Tao
authors.forename: Christa M
authors.initials: CM
authors.lastname: Musial
authors.forename: Fucheng
authors.initials: F
authors.lastname: Qu
authors.forename: Stephen
authors.initials: S
authors.lastname: Swartz
authors.forename: Sam T
authors.initials: ST
authors.lastname: Chao
authors.forename: Neil
authors.initials: N
authors.lastname: Flynn
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Murphy
authors.forename: Dorothy A
authors.initials: DA
authors.lastname: Slusarchyk
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Seethala
authors.forename: Mujing
authors.initials: M
authors.lastname: Yan
authors.forename: Paul
authors.initials: P
authors.lastname: Sleph
authors.forename: Gary
authors.initials: G
authors.lastname: Grover
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Blake
authors.initials: B
authors.lastname: Beehler
authors.forename: Leah
authors.initials: L
authors.lastname: Giupponi
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Dickinson
authors.forename: Hongjian
authors.initials: H
authors.lastname: Zhang
authors.forename: William G
authors.initials: WG
authors.lastname: Humphreys
authors.forename: Bharat P
authors.initials: BP
authors.lastname: Patel
authors.forename: Mark
authors.initials: M
authors.lastname: Schwinden
authors.forename: Terry
authors.initials: T
authors.lastname: Stouch
authors.forename: Peter T W
authors.initials: PT
authors.lastname: Cheng
authors.forename: Scott A
authors.initials: SA
authors.lastname: Biller
authors.forename: William R
authors.initials: WR
authors.lastname: Ewing
authors.forename: David
authors.initials: D
authors.lastname: Gordon
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Robl
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Tino
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002219:Carbamates / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D004285:Dogs; D004952:Esters; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008252:Macaca fascicularis; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D014867:Water
chemical_list: C526808:4-(hydroxybutyl)carbamic acid 2-(5-(1-(2-amino-2-methylpropionylamino)-2-benzyloxyethyl)tetrazol-1-yl)ethyl ester; D002219:Carbamates; D004952:Esters; D013777:Tetrazoles; D014867:Water; D019382:Human Growth Hormone; D013006:Growth Hormone