title: Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700.
abstract: Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b).
authors.affiliation: Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, R&D III, Plot No. 20, Sector-18, Udyog Vihar Industrial Area, Gurgaon, Haryana 122015, India.
authors.forename: Sonali
authors.initials: S
authors.lastname: Rudra
authors.forename: Ajay
authors.initials: A
authors.lastname: Yadav
authors.forename: A V S
authors.initials: AV
authors.lastname: Raja Rao
authors.forename: A S S V
authors.initials: AS
authors.lastname: Srinivas
authors.forename: Manisha
authors.initials: M
authors.lastname: Pandya
authors.forename: Pragya
authors.initials: P
authors.lastname: Bhateja
authors.forename: Tarun
authors.initials: T
authors.lastname: Mathur
authors.forename: Sunita
authors.initials: S
authors.lastname: Malhotra
authors.forename: Ashok
authors.initials: A
authors.lastname: Rattan
authors.forename: Mohammed
authors.initials: M
authors.lastname: Salman
authors.forename: Anita
authors.initials: A
authors.lastname: Mehta
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cliffe
authors.forename: Biswajit
authors.initials: B
authors.lastname: Das
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016984:Enterococcus faecium / Q000187:drug effects; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones