title: Association of endothelin-converting enzyme-1b C-338A polymorphism with gastric cancer risk: a case-control study.
abstract: To investigate the association between endothelin-converting enzyme-1b (ECE-1b) C-338A polymorphism and gastric cancer risk, we conducted a hospital-based case-control study of 256 gastric cancer cases and 256 controls matched on age and gender. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. We found that the genotype frequencies were significantly different (P=0.005) between cases and controls. Compared with the wild genotype CC, the variant genotypes (CA+AA) were associated with a 64% increased risk of gastric cancer [adjusted odds ratio (OR)=1.64, 95% confidence interval (CI) 1.15-2.33]. Further stratification analyses indicated that the increased risk was especially noteworthy in older subjects (age 58) (adjusted OR=1.91, 95% CI 1.18-3.09), women (adjusted OR=2.30, 95% CI 1.11-4.79) and non-smokers (adjusted OR=1.79, 95% CI 1.19-2.67). Our results suggest that the ECE-1b C-338A polymorphism may be associated with increased risk of gastric cancer.
authors.affiliation: Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu Province, China.
authors.forename: Haijuan
authors.initials: H
authors.lastname: Gu
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Naping
authors.initials: N
authors.lastname: Tang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Huaijun
authors.initials: H
authors.lastname: Zhu
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Sun
authors.forename: Rihong
authors.initials: R
authors.lastname: Cong
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000368:Aged; D016282:Aspartic Acid Endopeptidases / Q000235:genetics*; D016022:Case-Control Studies; D000072396:Endothelin-Converting Enzymes; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; D000072396:Endothelin-Converting Enzymes