title: SUMO teams up with ubiquitin to manage hypoxia.
abstract: Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.
authors.affiliation: Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK. helle.ulrich@cancer.org.uk
authors.forename: Helle D
authors.initials: HD
authors.lastname: Ulrich
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000172:deficiency / Q000378:metabolism*; D004921:Erythropoietin / Q000096:biosynthesis / Q000235:genetics; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D051379:Mice; D011485:Protein Binding; D025801:Ubiquitin / Q000378:metabolism*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000378:metabolism
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D025801:Ubiquitin; D004921:Erythropoietin; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C501974:Senp1 protein, mouse