title: Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease.
abstract: Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.
authors.affiliation: Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Merims
authors.forename: Nir
authors.initials: N
authors.lastname: Giladi
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects; D001526:Behavioral Symptoms / Q000209:etiology*; D004298:Dopamine / Q000378:metabolism*; D005715:Gambling; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D019966:Substance-Related Disorders / Q000209:etiology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa; D004298:Dopamine