title: Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus.
abstract: Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the progression of diabetic nephropathy. We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230). The overall genotypic distribution of -2518 A/G in the MCP-1 gene was not different in patients with type 2 DM compared to healthy controls. Although the genotype was not significantly different between the patients with kidney failure and the diabetic control (p=0.07), the A allele was more frequent in patients with kidney failure than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 1.07-3.18). In logistic regression analysis, carriage of A allele retained a significant association with diabetic kidney failure. Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM.
authors.affiliation: Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea.
authors.forename: Ju-young
authors.initials: JY
authors.lastname: Moon
authors.forename: Laeik
authors.initials: L
authors.lastname: Jeong
authors.forename: Sangho
authors.initials: S
authors.lastname: Lee
authors.forename: Kyunghwan
authors.initials: K
authors.lastname: Jeong
authors.forename: Taewon
authors.initials: T
authors.lastname: Lee
authors.forename: Chun-Gyoo
authors.initials: CG
authors.lastname: Ihm
authors.forename: Jungho
authors.initials: J
authors.lastname: Suh
authors.forename: Junghee
authors.initials: J
authors.lastname: Kim
authors.forename: Yoo-yeon
authors.initials: YY
authors.lastname: Jung
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D018932:Chemokine CCL2 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D051437:Renal Insufficiency; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2