The synthesis of naturally occurring peptides and their analogs.
The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.
Cupido
Tommaso
T
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1-5, Barcelona, Spain.
Tulla-Puche
Judit
J
Spengler
Jan
J
Albericio
Fernando
F
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D015195:Drug Design; D008956:Models, Chemical; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D001688:Biological Products; D010455:Peptides