title: Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer.
authors.affiliation: Institute of Experimental Haematology and Transfusion Medicine, Universität Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Müller
authors.forename: Bernhard
authors.initials: B
authors.lastname: Wulffen
authors.forename: Bernd
authors.initials: B
authors.lastname: Pötzsch
authors.forename: Günter
authors.initials: G
authors.lastname: Mayer
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D001483:Base Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D052157:Aptamers, Nucleotide; D004791:Enzyme Inhibitors; D008024:Ligands; D013917:Thrombin