title: Analysis of the effect of ageing on rising edge characteristics of the photoplethysmogram using a modified Windkessel model.
abstract: Ageing is one of the main contributing factors towards increasing arterial stiffness, leading to changes in peripheral pulses propagation. Therefore the characteristics of the photoplethysmogram (PPG) pulse, especially the rising edge and peak position, are greatly affected. In this study, the PPG pulse rising edge and corresponding peak position have been investigated non-invasively in human subjects as a function of age. Fifteen healthy subjects were selected and grouped in five age intervals, from 20 to 59 years, based on their comparable systolic-diastolic blood pressure and PPG amplitude. As expected, the peripheral pulse shows a steep rise and early peak in younger subjects. With age, the slope becomes blunted and in older subjects, the rise is very gradual and the pulse peak appears much later. Qualitative results were further verified by a modified 10-element Windkessel model to quantify the lumped parameter changes with ageing. This verification highlighted some specific changes in vascular parameters with aging. The rising edge could be considered as one parameter in determining the age-dependent vascular state.
authors.affiliation: School of Engineering, SHARIF University of Technology, Tehran, Iran. zahedi@sharif.edu
authors.forename: Edmond
authors.initials: E
authors.lastname: Zahedi
authors.forename: Kalaivani
authors.initials: K
authors.lastname: Chellappan
authors.forename: Mohd Alauddin Mohd
authors.initials: MA
authors.lastname: Ali
authors.forename: Harwant
authors.initials: H
authors.lastname: Singh
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D003187:Compliance; D005260:Female; D005385:Fingers / Q000098:blood supply; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D010991:Plethysmography / Q000379:methods*