title: [Community-acquired methicillin-resistant Staphylococcus aureus infections in a hospital for acute diseases].
abstract: Community-acquired methicillin-resistant Staphylococcus aureus infections in a hospital for acute diseases. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent pathogens associated with nosocomial infections. However, most recently, MRSA has arisen as an emerging community pathogen, causing serious infections, mainly among young patients. We herein describe 33 cases of infections caused by community-acquired MRSA (C-MRSA), diagnosed between May 2005 and June 2006, at "Eva Perón" Hospital. The isolations were retrospectively studied. Methicillin resistance was confirmed by means of the detection of the mecA gene, and the genes for two virulence factors (Panton-Valentine Leucocidin -PVL- and gamma-haemolysin) as well as the cassette mec type were screened by PCR. All the patients were previously healthy. Four patients under 12, presented bacteremia, one had serious pneumonia, and the three remaining patients had osteoarticular infections; all the patients over 12, had skin and soft tissue infections without systemic damage. The C-MRSA strains harboured cassette mec type IV, and the PVL and gamma-haemolysin genes. They were methicillin-resistant, with no other associated resistances. It is important to consider the presence of these community- acquired strains in order to develop strategies for their correct treatment.
authors.affiliation: Laboratorio de Bacteriología, Hospital Interzonal General de Agudos "Eva Perón" Balcarce 900, San Martín, Pcia. de Buenos Aires, Argentina. susanapalombarani@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Palombarani
authors.forename: N
authors.initials: N
authors.lastname: Gardella
authors.forename: A
authors.initials: A
authors.lastname: Tuduri
authors.forename: S
authors.initials: S
authors.lastname: Figueroa
authors.forename: G
authors.initials: G
authors.lastname: Sly
authors.forename: R
authors.initials: R
authors.lastname: Corazza
authors.forename: G
authors.initials: G
authors.lastname: Gutkind
authors.forename: M
authors.initials: M
authors.lastname: Almuzara
authors.forename: M
authors.initials: M
authors.lastname: Mollerach
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000453:epidemiology / Q000382:microbiology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005260:Female; D006782:Hospitals, Special / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics; D008875:Middle Aged; D046915:Penicillin-Binding Proteins; D011023:Pneumonia, Staphylococcal / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000453:epidemiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus