title: Alchemy in the soup: transforming metabolic signals to excitability.
abstract: The intersection of cell metabolism with electrical signaling links the environment and cell function over time scales ranging from milliseconds to lifetimes. In responding to cellular metabolites, adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels are an important component of this intersection. Recent studies have begun to delineate the roles of K(ATP) channels in multiple tissues and the far-reaching consequences of aberrant K(ATP) channel activity and disturbed sensing of cell metabolism.
authors.affiliation: Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. cnichols@cellbio.wustl.edu
authors.forename: Colin G
authors.initials: CG
authors.lastname: Nichols
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D054086:KATP Channels / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015220:Calcium Channels; D054086:KATP Channels; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate