title: Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy.
abstract: We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHbT/N=69+/-21%), oxyhemoglobin (rctO2HbT/N=73+/-25%), total hemoglobin (rctTHbT/N=72+/-17%), and lipid concentration (rctLipidT/N=116+/-13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N=75+/-7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.
authors.affiliation: University of Pennsylvania, Department of Physics & Astronomy, Philadelphia, Pennsylvania 19104, USA. chaozhou@alumni.upenn.edu
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Natasha
authors.initials: N
authors.lastname: Shah
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Amanda
authors.initials: A
authors.lastname: Durkin
authors.forename: David
authors.initials: D
authors.lastname: Hsiang
authors.forename: Rita
authors.initials: R
authors.lastname: Mehta
authors.forename: John
authors.initials: J
authors.lastname: Butler
authors.forename: Albert
authors.initials: A
authors.lastname: Cerussi
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Tromberg
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010100:Oxygen / Q000032:analysis*; D013055:Spectrophotometry, Infrared / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen