title: Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis.
abstract: BACKGROUND
  Sinonasal undifferentiated carcinoma (SNUC) is a relatively rare, aggressive malignancy of adulthood. Nasal glial heterotopia is a benign congenital condition in which mature benign brain tissue develops outside the central nervous system.
  
  
  METHODS
  A 37-year-old man was seen with right nasal obstruction, epistaxis, and headache. Imaging showed a radiologically malignant mass lesion. Biopsy and subsequent resection were performed in the evaluation and treatment of this lesion. Histologic and immunohistochemical assessments of the biopsy and resection specimens on the pathology material classified the lesional tissue.
  
  
  RESULTS
  Histology and immunohistochemistry of the biopsy specimen demonstrated an SNUC that was subsequently resected following chemotherapy. In addition to SNUC, the resection specimen revealed extensive, multifocal nasal glial heterotopia (so called "nasal glioma").
  
  
  CONCLUSIONS
  This is the first known case in the literature in which these 2 relatively rare entities coincide.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital for the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, USA. tetzlafm@uphs.upenn.edu
authors.forename: Michael T
authors.initials: MT
authors.lastname: Tetzlaff
authors.forename: Peter
authors.initials: P
authors.lastname: Liu
authors.forename: Bert W
authors.initials: BW
authors.lastname: O'Malley
authors.forename: Virginia A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: David
authors.initials: D
authors.lastname: Elder
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D009457:Neuroglia / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D020545:Respiratory Mucosa / Q000473:pathology*