Neuroblastoma.
Neuroblastomas continue to remain a clinical challenge, despite advances in multimodal therapy. Currently, studies are aimed at novel targets for neuroblastoma directed toward poor prognostic indicators such as the MYCN oncogene and marked angiogenesis. There have also been recent discoveries in neuroblastoma pathogenesis involving epigenetic regulation and retinoic acid therapy. Understanding the intricate complexities of this tumor may lead to innovative agents for more effective combinational therapy.
Ishola
Titilope A
TA
Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Chung
Dai H
DH
D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000209:etiology / Q000473:pathology / Q000628:therapy