title: Linkage disequilibrium mapping for complex disease genes.
abstract: In this chapter we lay out some background information about gene mapping for human complex traits. The chapter covers issues such as study design, high-throughput genotyping technologies, statistical analysis, and others. Many of the materials are based on and related to our recent experiences in case-control-association studies.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: DeWan
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Klein
authors.forename: Josephine
authors.initials: J
authors.lastname: Hoh
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D030561:Databases, Nucleic Acid; D004194:Disease; D004843:Epistasis, Genetic; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011786:Quality Control; D017422:Sequence Analysis, DNA