Expression of marker genes during otolith development in medaka.
Little is known about the genes and processes involved in the development of otoliths. In this study, we isolated the biomineralization-related genes otolin and chondromodulin-1 (chm1) from medaka, and examined their spatiotemporal expression pattern as well as that of two other genes also related to biomineralization, i.e., sparc/osteonectin and type II collagen (col2a), during otic development in medaka. Our results demonstrated that all the tested genes were expressed in the otic vesicle, and that chm1 was exclusively expressed in the semicircular canal of the otic vesicle.
Nemoto
Yoshiyuki
Y
Department of Biological Information, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Chatani
Masahiro
M
Inohaya
Keiji
K
Hiraki
Yuji
Y
Kudo
Akira
A
D000818:Animals; D015415:Biomarkers; D024043:Collagen Type II / Q000235:genetics; D004625:Embryo, Nonmammalian; D016326:Extracellular Matrix Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000235:genetics; D038081:Organogenesis; D009990:Oryzias / Q000196:embryology* / Q000235:genetics*; D015676:Osteonectin / Q000235:genetics; D010037:Otolithic Membrane / Q000196:embryology*; D012665:Semicircular Canals / Q000196:embryology / Q000378:metabolism
D015415:Biomarkers; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D008565:Membrane Proteins; D015676:Osteonectin; C449659:otolin-1