title: A novel functional translocator protein ligand for cancer imaging.
abstract: The translocator protein (TSPO) is an attractive target for tumor imaging due to its up-regulation in numerous cancer cell types. Here, we report a series of functional TSPO ligands, n-TSPOmbb732, which can be conjugated to a variety of signaling moieties and are widely applicable in TSPO-targeted molecular imaging. Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro.
authors.affiliation: Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, TN 37235-1822, USA.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Bai
authors.forename: Malena B
authors.initials: MB
authors.lastname: Rone
authors.forename: Vassilios
authors.initials: V
authors.lastname: Papadopoulos
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Bornhop
mesh_terms: D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009369:Neoplasms / Q000378:metabolism*; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D011506:Proteins