A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
Choi
Mi-Ran
MR
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Stanton-Maxey
Katie J
KJ
Stanley
Jennifer K
JK
Levin
Carly S
CS
Bardhan
Rizia
R
Akin
Demir
D
Badve
Sunil
S
Sturgis
Jennifer
J
Robinson
J Paul
JP
Bashir
Rashid
R
Halas
Naomi J
NJ
Clare
Susan E
SE
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001692:Biological Transport; D015687:Cell Hypoxia; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000648:ultrastructure; D009000:Monocytes / Q000187:drug effects / Q000648:ultrastructure; D053758:Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D013053:Spectrophotometry
D000970:Antineoplastic Agents