[Studies on chemical constituents of in herb Pyrola calliatha].
OBJECTIVE
To investigate the chemical constituents of Pyrola calliatha.


METHODS
The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data.


RESULTS
Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid (4), daucosterol (5), 2alpha,3beta,23,24-tetrahydroxy-12-ene-28-ursolic acid (6), emodin (7), gallic acid (8), monotropein (9), adenosine (10).


CONCLUSIONS
Compounds 2,4,6,7,10 were obtained from this genus for the first time, compounds 5, 9 were obtained from this species for the first time. Antifungal activity of compounds 1-4, 6-9 were evaluated. Compound 1 showed the strong activity.
Liu
Lei
L
School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Chen
Yu-ping
YP
Wan
Zhe
Z
Li
An-liang
AL
Li
Ruo-yu
RY
Tu
Peng-fei
PF
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003455:Cryptococcus neoformans / Q000187:drug effects; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D031828:Pyrola / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D039823:Iridoids; D009285:Naphthoquinones; D014315:Triterpenes; C507582:monotropein; C057774:chimaphilin; C013330:uvaol