title: [Diffuse myxoid malignant fibrous histiocytoma of the pleura: a case report and review of the literature].
abstract: OBJECTIVE
  To study the clinicopathologic characteristics of diffuse myxoid malignant fibrous histiocytoma (MFH) of pleura.
  
  
  METHODS
  The clinical and pathological features of a patient with diffuse myxoid MFH of pleura from this hospital were analyzed, and the reported literature of 7 patients with MFH of pleura were reviewed.
  
  
  RESULTS
  The patient was a 65-year-old male. The primary manifestations were cough, chest pain, breathlessness, and a great quantity of bloody pleural effusion. Chest CT scan showed diffuse masses on the visceral and parietal pleura. Exploratory thoracotomy exposed diffuse translucent gray-white masses on the surface of visceral and parietal pleura, with diameters of 1 - 8 cm. Microscopic findings showed that diffuse spindle-shaped and pleomorphic tumour cells were within the myxoid stroma. Tumor cells were positive for vimentin, CD(68), lysozyme, and negative for CK, EMA, and desmin. The patient died of obstruction of superior vena cava, and circulatory failure at 24th postoperative day. Different from cases with single or multiple MFH of pleura reported in the literature, this case of diffuse myxoid MFH had an abrupt onset, and progressed aggressively.
  
  
  CONCLUSIONS
  Diffuse myxoid MFH of pleura is a very rare high-grade malignant tumor with very poor prognosis.
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Tongji University, Shanghai 200433, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Xiang-hua
authors.initials: XH
authors.lastname: Yi
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Ye-liu
authors.initials: YL
authors.lastname: Liu
authors.forename: Ge-ning
authors.initials: GN
authors.lastname: Jiang
authors.forename: Jia-an
authors.initials: JA
authors.lastname: Ding
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010994:Pleura / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D010996:Pleural Effusion / Q000378:metabolism / Q000473:pathology; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D014746:Vimentin