Making the most of high-throughput protein-interaction data.
We review the estimation of coverage and error rate in high-throughput protein-protein interaction datasets and argue that reports of the low quality of such data are to a substantial extent based on misinterpretations. Probabilistic statistical models and methods can be used to estimate properties of interest and to make the best use of the available data.
Gentleman
Robert
R
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. rgentlem@fhcrc.org
Huber
Wolfgang
W
D030562:Databases, Protein; D013058:Mass Spectrometry; D015233:Models, Statistical; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D012107:Research Design; D020798:Two-Hybrid System Techniques
D011506:Proteins