title: Identification of the total peripheral resistance baroreflex impulse response from spontaneous hemodynamic variability: validation by chronic arterial baroreceptor denervation.
abstract: We have previously proposed a technique for estimating the static gain values and impulse response of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex by mathematical analysis of beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this study, we evaluated the technique with respect to spontaneous hemodynamic variability measured from seven conscious dogs before and after chronic arterial baroreceptor denervation. Our results show that the technique correctly predicted the alterations in TPR baroreflex functioning that are known to occur following the baroreceptor denervation.
authors.affiliation: Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. chenxia7@msu.edu
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Chen
authors.forename: Jong-Kyung
authors.initials: JK
authors.lastname: Kim
authors.forename: Javier A
authors.initials: JA
authors.lastname: Sala-Mercado
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hammond
authors.forename: Gokul
authors.initials: G
authors.lastname: Swamy
authors.forename: Tadeusz J
authors.initials: TJ
authors.lastname: Scislo
authors.forename: Donal S
authors.initials: DS
authors.lastname: O'Leary
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Mukkamala
mesh_terms: D000465:Algorithms; D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D003714:Denervation / Q000379:methods; D004285:Dogs; D008955:Models, Cardiovascular; D011311:Pressoreceptors / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology*