title: [The effects of the success of the synthesis of Stovaïne in science and industry. Ernest Fourneau (1872-1949) and the transformation of the field of medicinal chemistry in France].
abstract: The synthetic local anaesthetic Stovaine was commercialised in France in 1904. Its inventor, Ernest Fourneau, began his career as a pharmaceutical chemist in organic chemistry laboratories in Germany, where from 1899 to 1901 he discovered how basic research could benefit from the modern chemistry theories which had developed in Germany starting in the 1860s. Using the complex structure of cocaine, he invented an original molecule, with comparable activity, but less toxic. The knowledge and the know-how which he acquired in Germany nourished his reflection in the field of the chemistry of the relationships between structure and activity, and led him to the development of Stovaïne. Emile Roux, Director of the Pasteur Institute in Paris, was interested in his work and invited him to head the first French therapeutic chemistry laboratory, in which research on medicinal chemistry was organised scientifically. The industrial development of new medicines resulting from the Pasteur Institute's therapeutic chemistry laboratory was supported by the Etablissements Poulenc frères, France thus gaining international reputation in the domain of pharmaceutical chemistry.
authors.affiliation: christine.debue@wanadoo.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Debue-Barazer
mesh_terms: D000779:Anesthetics, Local / Q000266:history*; D001565:Benzoates / Q000266:history*; D004345:Drug Industry / Q000266:history*; D005602:France; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D012586:Science / Q000266:history*
chemical_list: D000779:Anesthetics, Local; D001565:Benzoates; C015677:amylocaine