title: Malignant sublingual gland tumors: a retrospective clinicopathologic study of 28 cases.
abstract: OBJECTIVE
  To evaluate the clinicopathologic features and therapeutic efficacy of malignant sublingual gland tumors.
  
  
  METHODS
  From 1955 to 2005, the clinicopathologic data of 28 patients treated in our hospital were obtained from their medical records and histopathologic slides.
  
  
  RESULTS
  There were 16 males and 12 females, with a mean age of 50.3 years. Eighteen cases (64.3%) were adenoid cystic carcinoma; 16 (57.1%) cases were clinically staged as III-IV. Adenoid cystic carcinoma was mainly of the histologic type, and the other histologic classifications included mucoepidermoid carcinoma, myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, adenocarcinoma and malignant pleomorphic adenoma. Pulmonary metastasis and tumor recurrence were the main death reasons. Eleven patients remain alive and well 34-312 months (median 108) after treatment.
  
  
  CONCLUSIONS
  Malignant sublingual gland tumors are extremely rare and most are adenoid cystic carcinoma. Surgery is the main treatment option. For adenoid cystic carcinoma, hematogenous spread is common, and pulmonary metastasis is a common pathway of the distant metastasis. For some patients having lung metastasis, regional control is also important as there are some examples of patients surviving many years with asymptomatic pulmonary metastases. Postoperative radiation therapy may be adjuvant for selected patients with high-stage and high-grade tumors, or when there is concern about the inadequacy of the resection. The effect of chemotherapy remains elusive.
authors.affiliation: Oral Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Qing-Hong
authors.initials: QH
authors.lastname: Gao
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wang
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Wen
authors.forename: Long-Jiang
authors.initials: LJ
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000473:pathology*; D002423:Cause of Death; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013362:Sublingual Gland Neoplasms / Q000401:mortality / Q000473:pathology*