title: The use of biodegradable scaffold as an alternative to silicone implant arthroplasty for small joint reconstruction: an experimental study in minipigs.
abstract: Biodegradable poly-L/D-lactide (P(L/D)LA) 96/4 joint scaffold arthroplasty is a recently clinically introduced concept in the reconstruction of small joints, however its histology and function in vivo is unknown. In this experimental study on 11 minipigs the fifth metacarpophalangeal joints were reconstructed using a P(L/D)LA 96/4 joint scaffold or Swanson silicone implant. They were evaluated until 3 years. The P(L/D)LA 96/4 joint scaffold formed a porous interposition spacer, which maintained the arthroplasty space and induced fibrous tissue in-growth in situ. No differences were found in the range of motion or arthroplasty space width between the study groups. The P(L/D)LA 96/4 joint scaffold was initially filled with vascular, loose connective tissue. Along with degradation of the scaffold, the in-grown connective tissue matured and condensed turning into dense fibrous connective tissue. After 3 years, the P(L/D)LA 96/4 joint scaffold had almost completely degraded and been replaced by dense fibrous connective tissue. These findings indicate that P(L/D)LA 96/4 joint scaffold arthroplasty leads to the formation of a functional fibrous joint. The avoidance of permanent foreign material makes the biodegradable joint scaffold an attractive alternative for small joint arthroplasty.
authors.affiliation: Department of Hand Surgery, Helsinki University Central Hospital, P.O. Box 266, FIN-00029 HUS, Helsinki, Finland. eero.waris@helsinki.fi <eero.waris@helsinki.fi>
authors.forename: Eero
authors.initials: E
authors.lastname: Waris
authors.forename: Nureddin
authors.initials: N
authors.lastname: Ashammakhi
authors.forename: Mauri
authors.initials: M
authors.lastname: Lehtimäki
authors.forename: Riitta-Mari
authors.initials: RM
authors.lastname: Tulamo
authors.forename: Minna
authors.initials: M
authors.lastname: Kellomäki
authors.forename: Pertti
authors.initials: P
authors.lastname: Törmälä
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000818:Animals; D001178:Arthroplasty; D001672:Biocompatible Materials; D019736:Prostheses and Implants; D012828:Silicones; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials; D012828:Silicones