title: Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography.
abstract: BACKGROUND
  There is increasing evidence that schizophrenia is characterized by abnormalities in white matter.
  
  
  OBJECTIVE
  To investigate the integrity of white matter tracts in adolescents with schizophrenia.
  
  
  METHODS
  Cross-sectional, case-control, whole-brain, voxel-based analysis and fiber tractography using diffusion tensor magnetic resonance imaging.
  
  
  METHODS
  University research institute.
  
  
  METHODS
  Forty-four individuals (age range, 11-18 years), 23 with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 21 demographically similar healthy controls.
  
  
  METHODS
  Fractional anisotropy, trace, and radial diffusivity of diffusion tensor and quantitative tractography.
  
  
  RESULTS
  Voxelwise analysis revealed that adolescents with schizophrenia had reduced fractional anisotropy within the left inferior temporal (P < .001) and occipital (P < .001) regions. Tractography was performed to extract the left and the right inferior longitudinal fasciculi (ILF). Measuring the mean diffusion indices along the left ILF, patients had significantly reduced fractional anisotropy (P < .001) as well as significantly increased radial diffusivity (P < .001) and trace (P = .003) after adjusting for differences in a measure thought to reflect premorbid intelligence, Wide Range Achievement Test 3 reading scores. Exploratory analyses revealed that patients with a history of visual hallucinations had lower fractional anisotropy in the left ILF (P = .02) than patients without visual hallucinations.
  
  
  CONCLUSIONS
  Our findings, which benefited from greater image resolution and methodological control than previous studies conducted in adolescents with schizophrenia, provide strong evidence for lower white matter integrity in the left ILF, particularly for patients with a history of visual hallucinations.
authors.affiliation: Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA. ashtari@email.chop.edu
authors.forename: Manzar
authors.initials: M
authors.lastname: Ashtari
authors.forename: John
authors.initials: J
authors.lastname: Cottone
authors.forename: Babak A
authors.initials: BA
authors.lastname: Ardekani
authors.forename: Kelly
authors.initials: K
authors.lastname: Cervellione
authors.forename: Philip R
authors.initials: PR
authors.lastname: Szeszko
authors.forename: Jinghui
authors.initials: J
authors.lastname: Wu
authors.forename: Steven
authors.initials: S
authors.lastname: Chen
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Kumra
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006212:Hallucinations / Q000473:pathology; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology*