Neuroprotection by early and delayed treatment of acute stroke with high dose aspirin.
Acetylsalicylic acid (ASA; Aspirin) has a neuroprotective potential by its anti-excitotoxic and anti-inflammatory effects. A temporary middle cerebral artery occlusion (tMCAO) model was used in 80 Wistar rats to evaluate whether a high dose of Aspirin (40 mg/kg) applied with different initiation time points after stroke onset (30 min, 3 h, 6 h, 12 h, 20 rats for each time group) and followed by repeated administration (1, 2 and 3 days) is neuroprotective. Neurological score and brain infarct volume were analyzed and indicated that postischemic therapy initiation at 30 min and as late as 6 h led to better neurological recovery (6 h, p=0.0046) and significant smaller infarct size (6 h, 57+/-9 mm(3), n=10, p=0.0043) compared to the saline control group (110+/-13 mm(3), n=10). Thus, there may be a relatively wide time window for acute stroke therapy with high dose Aspirin.
Zheng
Zhao
Z
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany.
Schwab
Stefan
S
Grau
Armin
A
Berger
Christian
C
D000208:Acute Disease; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001925:Brain Damage, Chronic / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
D018696:Neuroprotective Agents; D001241:Aspirin