Radiological aid to clinical diagnosis of Schnitzler's syndrome: multimodality imaging approach.
Schnitzler's syndrome is a rare combination of chronic urticaria, fever of unknown origin, disabling bone pain, and monoclonal gammopathy. We report a case with an unusual radiological manifestation as a solitary sclerotic lesion of the right iliac bone. Its main features on conventional radiography, computed tomography, and magnetic resonance imaging are described, and the main radiological differential diagnoses are discussed to help with the characterization of this syndrome, which requires a combination of clinical, laboratory, and radiological data. On the other hand, although our patient had an excellent clinical response to anakinra, the sclerotic lesion remained unchanged on follow-up X-ray examinations.
Flórez
Alejandro Fernández
AF
Department of Diagnostic Radiology, Faculty of Medicine, University Hospital Marqués de Valdecilla (HUMV), University of Cantabria, Avda. Valdecilla no. 25, 39008, Santander, Cantabria, Spain. alejandrofernandezflorez@hotmail.com
Gallardo Agromayor
Elena
E
García-Barredo
Rosario
R
Landeras Alvaro
Rosa Ma
RM
Gorriño Angulo
Miren
M
Martínez-Taboada
Victor Manuel
VM
Fernández Echevarría
Ma Antonia
MA
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003952:Diagnostic Imaging / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy / Q000473:pathology; D019873:Schnitzler Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014581:Urticaria / Q000188:drug therapy / Q000473:pathology
D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D008727:Methotrexate