Molecular epidemiology of rabies virus isolated from different sources during a bat-transmitted human outbreak occurring in Augusto Correa municipality, Brazilian Amazon.
We genetically characterize rabies virus (RABV) strains isolated from human cases, domestic and wild animals during a human outbreak of bat-transmitted rabies in Augusto Correa municipality, Pará state, Brazilian Amazon in 2005. Partial nucleotide sequences of the N gene (491 bp) were obtained for all strains, and phylogenetic analysis grouped these into two major clades (Pará and Central-Southeast) and identified them as bat-related viruses genotype I, Desmodus rotundus antigenic variant 3 (AgV3). A molecular clock was used to estimate the time of emergence for each RABV isolate. The molecular data from this study suggest the association of vampire bats with human and domestic animal cases reported in the outbreak, the circulation of at least two predominant lineages in the Pará state, and also a geographic association to lineages dispersion.
Barbosa
Taciana Fernandes Souza
TF
Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Belém, Brazil.
Medeiros
Daniele Barbosa de Almeida
DB
Travassos da Rosa
Elizabeth Salbe
ES
Casseb
Lívia Medeiros Neves
LM
Medeiros
Rita
R
Pereira
Armando de Souza
Ade S
Vallinoto
Antonio Carlos Rosário
AC
Vallinoto
Marcelo
M
Begot
Alberto Lopes
AL
Lima
Reynaldo José da Silva
RJ
Vasconcelos
Pedro Fernando da Costa
PF
Nunes
Márcio RobertoTeixeira
MR
D000293:Adolescent; D000328:Adult; D000818:Animals; D001483:Base Sequence; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002685:Chiroptera / Q000821:virology*; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D004199:Disease Vectors; D005260:Female; D005814:Genes, Viral; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D019590:Nucleocapsid Proteins / Q000235:genetics; D010802:Phylogeny; D011818:Rabies / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D013997:Time Factors
D017931:DNA Primers; D004279:DNA, Viral; D019590:Nucleocapsid Proteins; C099601:nucleocapsid protein, Rabies virus