Elevated TNF-alpha and LDH without parathormone disturbance is associated with diffuse osteolytic lesions in leukemic transformation of myelofibrosis.
Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of collagen in the bone marrow, extramedullary hematopoiesis, dacriocytosis, and leukoerythroblastic blood smear. Development and maintenance of fibrosis are mediated by a complex network of several cytokines, including tumor necrosis factor-alpha (TNF-alpha). Osteosclerosis is the most frequently observed bone change in myelofibrosis. Based on this, we present an atypical case of leukemic transformation in myelofibrosis associated with diffuse osteolytic lesions and extremely elevated TNF-alpha and lactate dehydrogenase (LDH). Parathormone was not disturbed.
Jurisic
Vladimir
V
School of Medicine, University of Kragujevac, P.O. Box 124, 34 000 Kragujevac, Serbia. vdvd@mailcity.com
Terzic
Tatjana
T
Pavlovic
Sonja
S
Colovic
Natasa
N
Colovic
Milica
M
D001853:Bone Marrow / Q000473:pathology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D010014:Osteolysis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood*; D010384:Pelvic Bones / Q000473:pathology; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D013234:Stem Cells / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D015854:Up-Regulation
D010281:Parathyroid Hormone; D014409:Tumor Necrosis Factor-alpha; D007770:L-Lactate Dehydrogenase