title: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
abstract: Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomolecules was reported in the scientific literature, only a few were potent against various types of liver damages. Of which, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have largely attracted the scientific community. This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow, India. arvindcimap@rediffmail.com
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
authors.forename: J K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Suaib
authors.initials: S
authors.lastname: Luqman
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: S P S
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D003474:Curcumin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D016207:Cytokines / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D010944:Plants; D020011:Protective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D012838:Silymarin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity
chemical_list: D002934:Cinnamates; D016207:Cytokines; D004224:Diterpenes; D005960:Glucosides; D017705:Lignans; D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D013764:Tetrahydronaphthalenes; C504394:kutkoside; C512682:hypophyllanthin; C030419:andrographolide; D019695:Glycyrrhizic Acid; C517985:phyllanthin; D003474:Curcumin; C082497:neoandrographolide