Trafficking and cellular distribution of voltage-gated sodium channels.
Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.
Cusdin
Fiona S
FS
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
Clare
Jeffrey J
JJ
Jackson
Antony P
AP
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D021381:Protein Transport; D015222:Sodium Channels / Q000378:metabolism*
D015222:Sodium Channels