Central representation of the RIII flexion reflex associated with overt motor reaction: an fMRI study.
Recent neuroimaging studies precised the functions of the brain regions included in the so-called "pain-matrix". They isolated brain structures mediating attentional, emotional, anticipatory, cognitive, and discriminative aspects of pain perception. Surprisingly, little attention was devoted to isolate the cerebral network associated with the motor response to pain. In this study, we used fMRI to measure BOLD signal changes in nine volunteers while they received low- (L-) and high- (H-) intensity painful electrical shocks on the (left) lower limb. High-intensity stimulation was associated with a significantly stronger pain sensation and with a pronounced motor (withdrawal) reflex. BOLD responses common to L- and H-stimulation intensities were found in the right prefrontal and right posterior parietal cortices. These did not correlate with subjective pain ratings and probably mediate attentional processes unrelated to pain intensity and withdrawal. In contrast, signal changes in insula, left SII cortices and right amygdala did correlate with pain ratings and are therefore likely to encode for pain intensity. High-intensity shocks selectively recruited a motor network, including vermis, MI, SI, and paracentral cortices bilaterally, right premotor, right SII and posterior cingulate cortices. These responses, assessed for the first time in a functional imaging study, emphazised on the presence of a motor component in what has been described as the pain-matrix. They should be considered as a motor component of pain-related processes activated in case of intense pain.
Peyron
R
R
Département de neurologie, CHU de St-Etienne, 42055 St-Etienne, France. Roland.Peyron@univ-st-etienne.fr
Kupers
R
R
Jehl
J L
JL
Garcia-Larrea
L
L
Convers
P
P
Barral
F G
FG
Laurent
B
B
D000328:Adult; D019540:Area Under Curve; D001933:Brain Stem / Q000502:physiology; D004558:Electric Stimulation; D004597:Electroshock; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold; D011601:Psychophysics; D012018:Reflex / Q000502:physiology*