Growth factors and heme oxygenase-1: perspectives in physiology and pathophysiology.
Growth factors are mediators of both normal homeostasis and pathophysiology through their effects on various cellular processes. Similarly, heme oxygenase-1 (HO-1) has a role in maintaining physiologic equilibrium, by which it can either alleviate or exacerbate disease, depending on several considerations, including amount, timing, and location of expression, as well as the disease setting. Thus, the synthesis and activities of growth factors and HO-1 are intricately regulated. Interestingly, several growth factors induce HO-1, and, conversely, HO-1 can regulate the expression of some growth factors. This review focuses on the influence of growth factors and HO-1 and potential physiologic effects of the growth factor(s)-HO-1 interaction.
Hill-Kapturczak
Nathalie
N
Department of Medicine, Nephrology Research and Training Center and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jarmi
Tambi
T
Agarwal
Anupam
A
D000208:Acute Disease; D000818:Animals; D004347:Drug Interactions; D004790:Enzyme Induction; D015971:Gene Expression Regulation, Enzymologic; D051547:Heme Oxygenase-1 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology; D008954:Models, Biological
D036341:Intercellular Signaling Peptides and Proteins; D051547:Heme Oxygenase-1