Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers.
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view. Fatalities associated with diphenoxylate-atropine have been reported in toddlers after repetitive or incorrect dosages. Fortunately, trends in pediatric diphenoxylate-atropine ingestions are decreasing. We review the management, trends, and current concepts regarding pediatric diphenoxylate-atropine ingestions.
Thomas
Tenny J
TJ
Department of Emergency Medicine, George Washington University, Washington, DC, USA.
Pauze
Denis
D
Love
Jeffrey N
JN
D001285:Atropine / Q000008:administration & dosage / Q000506:poisoning*; D002675:Child, Preschool; D004157:Diphenoxylate / Q000008:administration & dosage / Q000506:poisoning*; D004338:Drug Combinations; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007223:Infant; D008297:Male; D011041:Poisoning / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D014481:United States / Q000453:epidemiology
D004338:Drug Combinations; D005765:Gastrointestinal Agents; C002534:atropine sulfate-diphenoxylate hydrochloride drug combination; D004157:Diphenoxylate; D001285:Atropine