Synthesis and antitumor activity of amine analogs of irofulven.
Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs.
McMorris
Trevor C
TC
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Chimmani
Ramesh
R
Gurram
Mahender
M
Staake
Michael D
MD
Kelner
Michael J
MJ
D000230:Adenocarcinoma / Q000473:pathology; D000588:Amines / Q000737:chemistry*; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000588:Amines; D018906:Antineoplastic Agents, Alkylating; D012717:Sesquiterpenes; C102714:irofulven