Rheumatoid arthritis association at 6q23.
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).
Thomson
Wendy
W
Arthritis Research Campaign (arc)-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.
Barton
Anne
A
Ke
Xiayi
X
Eyre
Steve
S
Hinks
Anne
A
Bowes
John
J
Donn
Rachelle
R
Symmons
Deborah
D
Hider
Samantha
S
Bruce
Ian N
IN
Wilson
Anthony G
AG
Marinou
Ioanna
I
Morgan
Ann
A
Emery
Paul
P
Carter
Angela
A
Steer
Sophia
S
Hocking
Lynne
L
Reid
David M
DM
Wordsworth
Paul
P
Harrison
Pille
P
Strachan
David
D
Worthington
Jane
J
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22