title: Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof.
abstract: The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.
authors.affiliation: Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 (S4), B-9000 Gent, Belgium.
authors.forename: Samuël
authors.initials: S
authors.lastname: Demin
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Haver
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: De Clercq
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D007192:Indenes; D007659:Ketones; D007769:Lactams