[New methods of chemical and toxicological study of clonidine (Clophelinum)].
Clophelinum (clonidine) has hypotensive and soothing effect. The literature describes cases of a poisoning with clonidine, the majority of which are of the criminal character. Symptoms of clonidine intoxication differ from poisoning with other substances. Clinical picture of poisoning with clonidine is complex enough. Pathological and histological changes in internal organs in case of poisoning with clonidine are non specific. The methods of sampling, isolation, and qualitative determination need improvement. The aim of the research was investigation of chemical and toxicological properties of Clophelinum to develop new techniques of isolation and identification of clonidine. The technique of isolation is characterized by high degree of isolation (96 %), and technique of identification by high sensitivity (0,1 mkg/ml), which proves their efficiecy.
Adeishvili-Anguladze
L V
LV
Makharadze
R V
RV
Kurtsikidze
M Sh
MSh
Abuladze
N B
NB
Kintsurashvili
K M
KM
D000959:Antihypertensive Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D002845:Chromatography; D003000:Clonidine / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000652:urine
D000959:Antihypertensive Agents; D003000:Clonidine