title: Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease.
abstract: There is evidence to suggest a role for immune dysfunction in the pathogenesis of Alzheimer's disease, and it has previously been shown that blood plasma levels of the protein complement factor H, a member of the alternative complement pathway, was specifically elevated in people with late-onset Alzheimer's disease. We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk. However, it remains possible that another variant in this gene may modify susceptibility for late-onset Alzheimer's disease.
authors.affiliation: MRC Centre for Neurodegeneration, Institute for Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK. G.Hamilton@iop.kcl.ac.uk
authors.forename: Gillian
authors.initials: G
authors.lastname: Hamilton
authors.forename: Petra
authors.initials: P
authors.lastname: Proitsi
authors.forename: Julie
authors.initials: J
authors.lastname: Williams
authors.forename: Michael
authors.initials: M
authors.lastname: O'Donovan
authors.forename: Michael
authors.initials: M
authors.lastname: Owen
authors.forename: John
authors.initials: J
authors.lastname: Powell
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D019943:Amino Acid Substitution; D015331:Cohort Studies; D017242:Complement Factor H / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D017242:Complement Factor H; D004247:DNA