title: Activity-based fluorescent reporters for monoamine oxidases in living cells.
abstract: Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.
authors.affiliation: Department of Chemistry, University of California, Berkeley, CA 94720, USA.
authors.forename: Aaron E
authors.initials: AE
authors.lastname: Albers
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Rawls
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000737:chemistry*; D016716:PC12 Cells; D051381:Rats; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes; D008995:Monoamine Oxidase