title: Pregnancy rates after conservative treatment for borderline ovarian tumours: a systematic review.
abstract: Borderline ovarian tumours account for 10-15% of all ovarian cancers, and there have been numerous studies indicating their excellent long-term prognosis. As this disease commonly affects younger women, the issue of fertility-preserving surgery is increasingly important. A systematic review of the literature, searching the relevant electronic databases was performed analysing conservative surgery, borderline ovarian tumours and pregnancy rates/fertility outcome. Overall, 19 studies met the inclusion criteria. From these studies, 2479 patients had borderline ovarian tumours of which 923 (37%) patients were treated by conservative surgery. Nine studies recorded data regarding pregnancy outcome. A pregnancy rate of 48% was calculated on these data, where recorded, analysing the number of women wanting to conceive and the actual number of pregnancies achieved. The recurrence rate after conservative treatment was 16% with only five recorded disease-related deaths. Knowledge of the pregnancy rates is important to permit appropriate counselling of women diagnosed with this malignancy.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom.
authors.forename: Alexander
authors.initials: A
authors.lastname: Swanton
authors.forename: Clare R
authors.initials: CR
authors.lastname: Bankhead
authors.forename: Sean
authors.initials: S
authors.lastname: Kehoe
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000601:surgery*; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures; D006801:Humans; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000150:complications / Q000601:surgery*; D010052:Ovariectomy / Q000009:adverse effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome