Some uses of transition metal complexes as anti-cancer and anti-HIV agents.
The success of the clinical uses of cisplatin, cis-[Pt(II)(NH(3))(2)Cl(2)], has stimulated considerable interest in using other metal complexes as new therapeutic agents. This perspective describes our recent work on several classes of gold(III), platinum(II), ruthenium(II, III, IV), iron(II) and vanadium(IV) complexes for anti-cancer and anti-HIV treatments.
Sun
Raymond Wai-Yin
RW
Department of Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Ma
Dik-Lung
DL
Wong
Ella Lai-Ming
EL
Che
Chi-Ming
CM
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D008670:Metals / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology*
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D008670:Metals; D028561:Transition Elements