title: Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice.
abstract: Rice bran contains many phenolic acids, the most abundant of which is the antioxidant, ferulic acid (FA). We evaluated the hypoglycemic effects of a phenolic acid fraction (the ethyl acetate fraction, EAE) of rice bran and of FA in C57BL/KsJ db/db mice. Type 2 diabetic mice were allocated to a control group, an EAE group, or an FA group. Animals were fed a modified AIN-76 diet, and EAE or FA was administered orally for 17 days. There was no significant difference in body weight gain between groups. Administration of EAE and FA significantly decreased blood glucose levels and increased plasma insulin levels. EAE or FA groups had significantly elevated hepatic glycogen synthesis and glucokinase activity compared with the control group. Plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations were significantly decreased by EAE and FA administration. These findings suggest that EAE and FA may be beneficial for treatment of type 2 diabetes because they regulate blood glucose levels by elevating glucokinase activity and production of glycogen in the liver.
authors.affiliation: Food Function Research Center, Korea Food Research Institute, Kyeonggi-do 463-420, Republic of Korea.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Jung
authors.forename: Sung Ran
authors.initials: SR
authors.lastname: Kim
authors.forename: In Kyeong
authors.initials: IK
authors.lastname: Hwang
authors.forename: Tae Youl
authors.initials: TY
authors.lastname: Ha
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005941:Glucokinase / Q000378:metabolism; D062385:Hydroxybenzoates / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza / Q000737:chemistry*; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D003373:Coumaric Acids; D062385:Hydroxybenzoates; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; C004999:ferulic acid; D005941:Glucokinase; C017616:phenolic acid