Intermittent dietary restriction as a practical intervention in aging.
Recent studies on the effects of dietary restriction (DR) in rodents and primates have shown that even late-onset short-term regimens can bring about comparable beneficial changes seen in animals subjected to life-long DR. We examined the effect of 3 months of DR on the expression of antioxidant enzymes and antioxidants, heat-shock protein 70 (HSP-70), neural cell adhesion molecule (NCAM) and its polysialylated form, PSA-NCAM, as well as astrocytic marker glial fibrillary acidic protein (GFAP) in 18-month-old middle-aged rats. The present study shows that DR initiated in late adulthood confers beneficial effects, such as attenuation of oxidative stress, enhanced expression of HSP-70, neural plasticity markers NCAM, and PSA-NCAM, and reduced levels of GFAP.
Sharma
Sandeep
S
Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
Kaur
Gurcharan
G
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D005508:Food Deprivation / Q000502:physiology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D039842:Neural Cell Adhesion Molecule L1 / Q000096:biosynthesis / Q000235:genetics; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012794:Sialic Acids / Q000096:biosynthesis / Q000235:genetics; D015854:Up-Regulation / Q000502:physiology
D018840:HSP70 Heat-Shock Proteins; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule