Catalytic enantioselective stereoablative reactions: an unexploited approach to enantioselective catalysis.
Approaches to the preparation of enantioenriched materials via catalytic methods that destroy stereogenic elements of a molecule are discussed. Although these processes often decrease overall molecular complexity, there are several notable advantages including material recycling, enantiodivergence and convergence, and increased substrate scope. Examples are accompanied by discussion of the critical design elements required for the success of these methods.
Mohr
Justin T
JT
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, MC 164-30, Pasadena, CA 91125, USA.
Ebner
David C
DC
Stoltz
Brian M
BM
D000438:Alcohols / Q000737:chemistry; D000478:Alkylation; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010782:Photolysis; D012451:Safrole / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry
D000438:Alcohols; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; D013440:Sulfides; C521894:amurensinine; D012451:Safrole; C005746:sulfoxide