Ligands for practical rhodium-catalyzed asymmetric hydroformylation.
A series of bis-phosphite and bis-phosphine ligands for asymmetric hydroformylation reactions has been evaluated. Bis-phosphite ligands lead, in general, to high regioselectivities across a range of substrates while good enantioselectivities are limited to only a few examples. We found that bis-phospholane-type ligands, such as bis-diazaphospholanes and bis-phospholanes, can lead to very high regio- and enantioselectivities for several different substrates.
Klosin
Jerzy
J
Corporate R&D, The Dow Chemical Company, 1776 Building, Midland, Michigan 48674, USA. jklosin@dow.com
Landis
Clark R
CR
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D017553:Phosphorus Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D008024:Ligands; D017553:Phosphorus Compounds; D012238:Rhodium