title: [Study on the characteristic of Surveillance Creutzfeldt-Jakob disease patients from January to August in 2006 in China].
abstract: OBJECTIVE
  To describe the incidence condition and characteristic of Creutzfeldt-Jakob disease (CJD) in China.
  
  
  METHODS
  The clinical and epidemical information of patients from China CJD surveillance network was analyzed. Blood and cerebrospinal fluid (CSF) specimens from these patients were differently collected to be used to detect the 14-3-3 protein in the CSF and to analyze the PRNP gene.
  
  
  RESULTS
  Ten possible and 8 probable clinically diagnosed CJD patients were found. These patients had sporadic CJD. There were no geographic clustering and occupational risk with these patients. The mean age at onset of disease was approximately 60 years. The male to female ratio was approximately 1:1; rapidly progressive dementia was the main early symptom, which was present in 44% of patients.
  
  
  CONCLUSIONS
  The geographic distribution, occupation, the ratio of male to female and the mean age of onset were consistent with the characteristics of sporadic CJD.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gao
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
authors.forename: Bao-Yun
authors.initials: BY
authors.lastname: Zhang
authors.forename: Ni-Juan
authors.initials: NJ
authors.lastname: Xiang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Gao
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Dong
mesh_terms: D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000328:Adult; D000368:Aged; D015153:Blotting, Western; D002681:China / Q000453:epidemiology; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics
chemical_list: D048948:14-3-3 Proteins; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions