title: Expression of marker genes during otolith development in medaka.
abstract: Little is known about the genes and processes involved in the development of otoliths. In this study, we isolated the biomineralization-related genes otolin and chondromodulin-1 (chm1) from medaka, and examined their spatiotemporal expression pattern as well as that of two other genes also related to biomineralization, i.e., sparc/osteonectin and type II collagen (col2a), during otic development in medaka. Our results demonstrated that all the tested genes were expressed in the otic vesicle, and that chm1 was exclusively expressed in the semicircular canal of the otic vesicle.
authors.affiliation: Department of Biological Information, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nemoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Chatani
authors.forename: Keiji
authors.initials: K
authors.lastname: Inohaya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Akira
authors.initials: A
authors.lastname: Kudo
mesh_terms: D000818:Animals; D015415:Biomarkers; D024043:Collagen Type II / Q000235:genetics; D004625:Embryo, Nonmammalian; D016326:Extracellular Matrix Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000235:genetics; D038081:Organogenesis; D009990:Oryzias / Q000196:embryology* / Q000235:genetics*; D015676:Osteonectin / Q000235:genetics; D010037:Otolithic Membrane / Q000196:embryology*; D012665:Semicircular Canals / Q000196:embryology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D008565:Membrane Proteins; D015676:Osteonectin; C449659:otolin-1