[Effects of wearing long-term Ortho-K contact lens on corneal thickness and corneal endothelium].
OBJECTIVE
The current study evaluated the response of the cornea to more than 3 years of Ortho-K CL wearing by investigating the changes of corneal thickness and corneal endothelium.


METHODS
One hundred and thirty-two subjects were fitted with Ortho-K CL (Dk 100), which were worn overnight or daily for more than 3 years. Central and para-peripheral corneal thickness and corneal endothelium were measured before and during this period by using A scan pachymeter and non contact specular microscope.


RESULTS
There were no significant changes in corneal thickness (P < 0.05) and corneal endothelial polymegathism and pleomorphism could not be found after long-term wearing of Ortho-K CL (overnight or daily wear).


CONCLUSIONS
This study shows that high Dk Ortho-K CL used for scientific reshaping treatment only induces mild corneal response. Therefore, the Ortho-K CL can be worn safely for long-term control of myopia.
Xie
Pei-ying
PY
Peking University Optometry & Ophthalmology Center, Beijing 100083, China. xpy@b-d.ac.cn
Chi
Hui
H
Zhang
Ying
Y
Zhu
Gui-min
GM
Liu
Jun
J
D000293:Adolescent; D000328:Adult; D002648:Child; D003261:Contact Lenses; D003315:Cornea / Q000473:pathology*; D004728:Endothelium, Corneal / Q000473:pathology*; D004869:Equipment Safety; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000628:therapy; D054158:Orthokeratologic Procedures / Q000295:instrumentation*; D055815:Young Adult