title: AP-1 a target for cancer prevention.
abstract: The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.
authors.affiliation: Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
authors.forename: Connie P
authors.initials: CP
authors.lastname: Matthews
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Colburn
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Young
mesh_terms: D002471:Cell Transformation, Neoplastic; D018890:Chemoprevention; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009369:Neoplasms / Q000517:prevention & control*; D018808:Transcription Factor AP-1 / Q000502:physiology*
chemical_list: D018808:Transcription Factor AP-1