title: A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer.
abstract: OBJECTIVE
  The aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder--radical cystectomy and chemo radiation.
  
  
  METHODS
  Transitional cell carcinoma (TCC) of bladder of stages, T2 to T4, N0/N1/N2 and M0 were included in the study. Patients were allotted to two arms of the study. Arm A consisted of radical cystectomy. Adjuvant CMV chemotherapy was given for T3/T4 or Node positive disease only. Arm B received 2 cycles of neoadjuvant CMV chemo therapy followed by concurrent chemo radiation.
  
  
  RESULTS
  Forty-four patients were recruited into the study. Thirty patients in the surgical arm and 13 patients in the chemo radiation arm. The actuarial two-year survival rate in surgical arm is 56% while in chemo radiation arm it is 54%. There was no statistically significant difference in disease-free survival also between the two groups.
  
  
  CONCLUSIONS
  Chemo radiation yielded equivalent survival results with radical cystectomy. So it is worth giving preference to chemo radiation that will give a better quality of life for the patient.
authors.affiliation: Department of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi-110 029, India. kpharesh@rediffmail.com
authors.forename: K P
authors.initials: KP
authors.lastname: Haresh
authors.forename: P K
authors.initials: PK
authors.lastname: Julka
authors.forename: D N
authors.initials: DN
authors.lastname: Sharma
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
authors.forename: R
authors.initials: R
authors.lastname: Prabhakar
authors.forename: A
authors.initials: A
authors.lastname: Seth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D009361:Neoplasm Invasiveness; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*