Copper/silver-cocatalyzed Conia-ene reaction of linear beta-alkynic beta-ketoesters.
A novel and general copper/silver catalytic system has been developed for the Conia-ene intramolecular reaction of linear beta-alkynic beta-ketoesters. In the presence of (CuOTf)2.C6H6 and AgSbF6 (or AgOAc), a variety of the linear beta-alkynic beta-ketoesters selectively underwent the Conia-ene intramolecular reaction in moderate to good yields.
Deng
Chen-Liang
CL
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081, China.
Song
Ren-Jie
RJ
Guo
Sheng-Mei
SM
Wang
Zhi-Qiang
ZQ
Li
Jin-Heng
JH
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D004952:Esters; D007659:Ketones; D012834:Silver; D003300:Copper