Fenbendazole treatment may influence lipopolysaccharide effects in rat brain.
In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.
Hunter
Randy L
RL
Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA. rhunt2@uky.edu
Choi
Dong-Young
DY
Kincer
Jeanie F
JF
Cass
Wayne A
WA
Bing
Guoying
G
Gash
Don M
DM
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D001253:Astrocytes / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D005273:Fenbendazole / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D017628:Microglia / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012189:Retrospective Studies; D015431:Weight Loss / Q000187:drug effects
D000969:Antinematodal Agents; D008070:Lipopolysaccharides; D005273:Fenbendazole; D004298:Dopamine