New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.
The fruiting body of Inonotus obliquus, a medicinal mushroom called chaga, has been used as a traditional medicine for cancer treatment. Although this mushroom has been known to exhibit potent antioxidant activity, the mechanisms responsible for this activity remain unknown. In our investigation for free radical scavengers from the methanolic extract of this mushroom, inonoblins A (1), B (2), and C (3) were isolated along with the known compounds, phelligridins D (4), E (5), and G (6). Their structures were established by extensive spectroscopic analyses. These compounds exhibited significant scavenging activity against the ABTS radical cation and DPPH radical, and showed moderate activity against the superoxide radical anion.
Lee
In-Kyoung
IK
Functional Metabolites Research Center, KRIBB, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.
Kim
Young-Sook
YS
Jang
Yoon-Woo
YW
Jung
Jin-Young
JY
Yun
Bong-Sik
BS
D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D059808:Polyphenols
D000975:Antioxidants; D005419:Flavonoids; D005609:Free Radicals; D010636:Phenols; D059808:Polyphenols