title: Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles.
abstract: The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds. Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson's disease, Alzheimer's disease and rheumatoid arthritis.
authors.affiliation: Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg University, Staudingerweg 5, DE-55128 Mainz, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Scholz
authors.forename: Holger K
authors.initials: HK
authors.lastname: Ulbrich
authors.forename: Gerd
authors.initials: G
authors.lastname: Dannhardt
mesh_terms: D001393:Azoles / Q000737:chemistry / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018036:Selenium Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001393:Azoles; D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D018036:Selenium Compounds