title: Ingenane diterpenoids from Euphorbia esula.
abstract: An extensive study of metabolites present in Euphorbia esula led to isolation of 16 ingenane diterpenoids 1-16 together with the known ingenane derivative 17 and four known cycloartane triterpenoids. Their structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. All the compounds were assayed for their inhibitory activity against human HeLa cervical cancer cell line.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Guo Shoujing Road 199, Zhangjiang, Shanghai 201203, PR China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Jin-Qiang
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Guang-Tong
authors.initials: GT
authors.lastname: Chen
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Huang
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C530110:ingenane