[Changes in vertically transmitted human immunodeficiency virus infection Chile].
The identification of various risk factors of vertical human immunodeficiency virus (HIV) transmission resulted in the development of strategies whose aim was to decrease the mother's viral load, to reduce her child's exposure to it during delivery, and to avoid the subsequent viral exposure due to breastfeeding. The administration of antiretroviral treatment during pregnancy, delivery and to the neonate (PACTG 076) proved to be useful. At a first stage, zidovudine was used. A triple combination therapy was then administered. Initially, the viral transmission in mothers who were enrolled in protocols for vertically transmitted HIV prophylaxis was reduced to 9.5%, whereas the last measurement carried out between 1998 and 2005, the initial figure was brought down to 2%. Nevertheless, the delivery of infected children whose mother's HIV status was unknown is still considered likely to happen. The main step to be taken to reduce HIV infection among children is to perform universal HIV tests during pregnancy, so that HIV positive pregnant patients conveniently receive proper prophylaxis. We look forward to achieving this by following the new prevention guidelines of vertically-transmitted HIV infection, developed by the Comisión Nacional del SIDA of the Chilean Health Ministry.
Chávez P
Ana
A
Hospital Dr. Exequiel González Cortés, Santiago, Chile. anachavez@mi.cl
Alvarez P
Ana M
AM
Wu H
Elba
E
Peña D
Anamaría
A
Vizueta R
Eloísa
E
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002677:Chile / Q000453:epidemiology; D002985:Clinical Protocols; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000628:therapy / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control* / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000453:epidemiology
D019380:Anti-HIV Agents