title: Influence of chronic obstructive pulmonary disease on postoperative lung function and complications in patients undergoing operations for primary non-small cell lung cancer.
abstract: OBJECTIVE
  Recent data have suggested that there is a flexibility of borderline values of lung function tests in allowing safe lung resection. The aim of this study was to assess the pattern of postoperative lung function change in patients with chronic obstructive pulmonary disease compared with that of patients with normal lung function, and to compare the operative morbidity and mortality between these groups.
  
  
  METHODS
  The study included 35 patients with chronic obstructive pulmonary disease and a control group of 47 patients with normal lung function who underwent lung resection for non-small cell lung cancer. The percent changes of lung function parameters after lung resection and operative morbidity and mortality were compared between groups.
  
  
  RESULTS
  The mean postoperative loss in forced expiratory volume in the 1st second was significantly less in patients with chronic obstructive pulmonary disease who underwent lobectomy compared with that of patients with normal lung function (11.88% vs 24.6%, P < .05); forced expiratory flows at low lung volumes (50% and 25%) improved in patients who underwent lobectomy. The lung function change after pneumonectomy followed the same trend as that after lobectomy. In patients with chronic obstructive pulmonary disease, forced expiratory volume in the 1st second and small airways function significantly improved after preoperative bronchodilator therapy. In the group with chronic obstructive pulmonary disease, operative mortality was 0 and operative morbidity was 51.43%.
  
  
  CONCLUSIONS
  Because the pattern of lung function change is different in patients with chronic obstructive pulmonary disease compared with that of patients with normal lung function, surgery can be offered to carefully selected patients with lung cancer, even in the presence of severely limited lung function.
authors.affiliation: Institute for Lung Diseases, Clinical Center of Serbia, Belgrade, Serbia. vilusi@yubc.net
authors.forename: Dragan R
authors.initials: DR
authors.lastname: Subotic
authors.forename: Dragan V
authors.initials: DV
authors.lastname: Mandaric
authors.forename: Tatjana M
authors.initials: TM
authors.lastname: Eminovic
authors.forename: Milan M
authors.initials: MM
authors.lastname: Gajic
authors.forename: Natasa M
authors.initials: NM
authors.lastname: Mujovic
authors.forename: Nikola D
authors.initials: ND
authors.lastname: Atanasijadis
authors.forename: Predrag P
authors.initials: PP
authors.lastname: Dzeletovic
authors.forename: Ljiljana D
authors.initials: LD
authors.lastname: Andric
authors.forename: Branka M
authors.initials: BM
authors.lastname: Bulajic
authors.forename: Ivan D
authors.initials: ID
authors.lastname: Dimitrijevic
authors.forename: Dragana P
authors.initials: DP
authors.lastname: Sobic
mesh_terms: D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009026:Mortality; D011013:Pneumonectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D011183:Postoperative Complications; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012129:Respiratory Function Tests
chemical_list: D001993:Bronchodilator Agents