title: Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.
abstract: Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus.
authors.affiliation: Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Lira
authors.forename: Alan X
authors.initials: AX
authors.lastname: Xiang
authors.forename: Thomas
authors.initials: T
authors.lastname: Doundoulakis
authors.forename: William T
authors.initials: WT
authors.lastname: Biller
authors.forename: Konstantinos A
authors.initials: KA
authors.lastname: Agrios
authors.forename: Klaus B
authors.initials: KB
authors.lastname: Simonsen
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Webber
authors.forename: Wes
authors.initials: W
authors.lastname: Sisson
authors.forename: Robert M
authors.initials: RM
authors.lastname: Aust
authors.forename: Amit M
authors.initials: AM
authors.lastname: Shah
authors.forename: Richard E
authors.initials: RE
authors.lastname: Showalter
authors.forename: Virginia N
authors.initials: VN
authors.lastname: Banh
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Steffy
authors.forename: James R
authors.initials: JR
authors.lastname: Appleman
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008745:Methylation; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007783:Lactones; C040323:myxopyronin B; D012321:DNA-Directed RNA Polymerases