Limiting the proliferation of polyploid cells.
Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.
Ganem
Neil J
NJ
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Pellman
David
D
D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D002477:Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D011123:Polyploidy; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53