title: The risk of metabolic syndrome according to the high-sensitivity C-reactive protein in apparently healthy Koreans.
abstract: BACKGROUND
  Recently, considerable interest has been focused on the positive relationship between inflammation and the metabolic syndrome (MS). Therefore, we investigated whether the baseline plasma levels of the high-sensitivity C-reactive protein could be associated with future risk for MS in apparently healthy Koreans.
  
  
  METHODS
  A total of 1132 subjects (767 men, 365 women with a mean age of 49 years), who underwent health examination at this hospital in both 2002 and 2005 were enrolled. The criteria for metabolic syndrome followed that of NCEP-ATP III guideline except waist circumference. Instead, BMI (>/=25 kg/m(2)) was used for the measurement for obesity.
  
  
  CONCLUSIONS
  The relative risks of future MS in the highest quartile of high-sensitivity C-reactive protein at baseline were 2.4 (95% confidence interval [CI], 1.3-4.2) as compared to the subjects in the lowest quartile. Positive associations persisted after adjustment for age, sex and smoking; multivariate relative risks for the highest vs lowest quartiles were 2.3 (95% CI, 1.3-4.1; P for trend=0.005). This retrospective study suggests that elevated levels of high-sensitivity C-reactive protein could be associated with incident MS.
authors.affiliation: Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung-dong, Seoul 110-746, South Korea.
authors.forename: Chan-Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Se-Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Hun-Sub
authors.initials: HS
authors.lastname: Shin
authors.forename: Hung Dai
authors.initials: HD
authors.lastname: Kim
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Chul-Young
authors.initials: CY
authors.lastname: Park
authors.forename: Ki-Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun-Woo
authors.initials: SW
authors.lastname: Kim
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D010865:Pilot Projects; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein