title: [The regulation of gene expression by glucose].
abstract: Glucose should not be considered uniquely as a cellular fuel but also as a signaling molecule involved in the regulation of genes encoding glycolytic and lipogenic enzymes and, as such, in storage of triglycerides. Transcriptional effects of glucose on glycolytic and lipogenic enzymes involve a specific transcription factor, ChREBP, whose characteristics and mechanism of activation are described. Finally, the possible implication of ChREBP in the physiopathology of obesity and type 2 diabetes are discussed.
authors.affiliation: INSERM U567, CNRS UMR 8104, Université Paris Descartes, Département d'Endocrinologie, Métabolisme et Cancer, Faculté de Médecine Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris. girard@cochin.inserm.fr
authors.forename: Jean
authors.initials: J
authors.lastname: Girard
authors.forename: Renaud
authors.initials: R
authors.lastname: Dentin
authors.forename: Fadila
authors.initials: F
authors.lastname: Benhamed
authors.forename: Pierre-Damien
authors.initials: PD
authors.lastname: Denechaud
authors.forename: Catherine
authors.initials: C
authors.lastname: Postic
mesh_terms: D005786:Gene Expression Regulation / Q000502:physiology*; D005947:Glucose / Q000502:physiology*; D006019:Glycolysis / Q000235:genetics; D006801:Humans; D008055:Lipids / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014280:Triglycerides / Q000502:physiology
chemical_list: D008055:Lipids; D014157:Transcription Factors; D014280:Triglycerides; D005947:Glucose