title: Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage.
abstract: Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention.
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Tufts-New England Medical Center, Boston, Mass., USA. odammann@tufts-nemc.org
authors.forename: Olaf
authors.initials: O
authors.lastname: Dammann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bueter
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
authors.forename: Christiane E L
authors.initials: CE
authors.lastname: Dammann
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D020890:Neuregulin-1 / Q000502:physiology*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism
chemical_list: D020890:Neuregulin-1; D020794:Receptor Protein-Tyrosine Kinases