LEF-1 activates the transcription of E2F1.
LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further beta-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.
Zhou
Fangfang
F
State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
Zhang
Long
L
Gong
Kai
K
Lu
Guangyuan
G
Sheng
Baiyang
B
Wang
Aijun
A
Zhao
Nanming
N
Zhang
Xiufang
X
Gong
Yandao
Y
D000818:Animals; D019556:COS Cells; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000378:metabolism*; D015533:Transcriptional Activation
D050687:E2F1 Transcription Factor; D051821:Lymphoid Enhancer-Binding Factor 1; D006655:Histone Deacetylases