Solid-phase olefin cross-metathesis promoted by a linker.
Olefin cross-metathesis couples two alkenes to form complex molecules and has been widely used in solution-phase organic synthesis. However, this powerful method has rarely been used in solid-phase organic synthesis. Herein we report that olefin cross-metathesis is a synthetically viable method particularly when a traceless longer linker is inserted between solid support and reacting olefins.
Garner
Amanda L
AL
Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
Koide
Kazunori
K
D000438:Alcohols / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D015394:Molecular Structure
D000438:Alcohols; D000475:Alkenes; D003432:Cross-Linking Reagents; D004852:Epoxy Compounds