title: Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery.
abstract: OBJECTIVE
  To compare posterior capsule opacification (PCO) in rabbits who undergo cataract surgery and receive either mitomycin-C (MMC) or distilled water (DW) during sealed-capsule irrigation (SCI). In addition, we examined the toxicity of DW and MMC.
  
  
  METHODS
  Twenty-four eyes from 12 rabbits were divided into three groups. Balanced salt solution (BSS), DW, MMC 0.4 mg/mL was injected into the capsular bag for 2 min after endocapsular phacoemulsification and insertion of a SCI device. The degree of PCO was assessed by POCOman software at 3 months post surgery. Central corneal thickness, anterior chamber inflammation were assessed 1 day, 1 week, 2 weeks, 3 weeks, 1 month and 3 months postoperatively.
  
  
  RESULTS
  A statistically significant difference in PCO scores was noted between the control and study groups (P < 0.05). The PCO scores of the MMC group were significantly lower than those of the DW group (P < 0.05). The MMC and DW groups did not show significant toxicity compared with the BSS group.
  
  
  CONCLUSIONS
  MMC is more effective in reducing PCO than DW; the SCI device can protect the surrounding ocular tissue from MMC toxicity in rabbit eyes.
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Su-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jin-Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Choi
authors.forename: Choun-Ki
authors.initials: CK
authors.lastname: Joo
mesh_terms: D000818:Animals; D000963:Antimetabolites; D002386:Cataract / Q000517:prevention & control*; D007903:Lens Capsule, Crystalline / Q000187:drug effects*; D016685:Mitomycin / Q000008:administration & dosage*; D018918:Phacoemulsification; D011817:Rabbits; D007507:Therapeutic Irrigation / Q000379:methods*; D014867:Water / Q000008:administration & dosage*
chemical_list: D000963:Antimetabolites; D014867:Water; D016685:Mitomycin