gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acids.
A facile synthesis of alpha,beta-unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids.
Augustine
John Kallikat
JK
Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India. john.kallikat@syngeneintl.com
Naik
Yanjerappa Arthoba
YA
Mandal
Ashis Baran
AB
Chowdappa
Nagaraja
N
Praveen
Vinuthan B
VB
D000447:Aldehydes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D001555:Benzene Derivatives; D002264:Carboxylic Acids; D008314:Malonates; C030290:malonic acid