[Two ways of constructing concealed penis model in rats: a comparative and analytical study].
OBJECTIVE
To establish a stable rat experimental model of concealed penis for studying the effect of buried penis on the structure and function of the corpus cavernosum.


METHODS
Ninety male SD rats, aged 2 weeks, were randomly divided into 3 groups (A, B and C) of equal number. Groups A and B underwent surgery with intra-purse suture of the penile root and folding suture of the prepuce, respectively, to bury the penis, while Group C were included as sham operation controls.


RESULTS
In Group A, death resulted in 4 cases from acute post-operative urine retention, failure in burying the penis occurred in 5 cases because of soft tissue ulceration around the urethral orifice and in another 3 due to loose concealment. In Group B, 1 died from deep anesthesia and 2 from acute post-operative urine retention. With the penile development and erection, 7 in Group A and 10 in Group B protruded the penis in different stages. In Group C, 1 died from deep anesthesia. The operations succeeded in all the other rats in Groups A and B, with the success rates of 36.7% and 56.7%, respectively. And the concealment could be relieved any time during the experiment.


CONCLUSIONS
The experimental rat model of concealed penis can be successfully established by both intra-purse suture of the penile root and folding suture of the prepuce, which is stable and similar to the natural course of this disorder in human.
Yu
Wei-Min
WM
Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China.
Cheng
Fan
F
Zhang
Xiao-Bin
XB
Liu
Xiu-Heng
XH
Zhang
Jie
J
Xia
Yue
Y
Ge
Ming-Huan
MH
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010413:Penis / Q000002:abnormalities* / Q000601:surgery; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014564:Urogenital Abnormalities