title: Advanced pediatric inoperable thymus carcinoma (type C thymoma): case report on a novel therapeutic approach.
abstract: Although there has been considerable advancement in treatment techniques but still there are some illnesses that continue to exhibit a rather poor curability, such as thymoma. This report highlights the benefit of octreotide and prednisolone therapy in a 15-year-old girl, who was diagnosed with inoperable thymus carcinoma, with chemotherapy and radiotherapy being the last resort. The detection of type 2 somatostatin receptors on the surface of the tumor justified the introduction of treatment with somatostatin analog and prednisolone. Fortunately, after 6 months of this treatment, the tumor showed partial regression. However, 2 months later, somatostatin receptor negative metastases appeared; therefore, a switch over to imatinib became essential, because the tumor was CD-117 positive. Despite the therapy change, the patient's condition deteriorated owing to tumor progression.
authors.affiliation: 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary. gkertesz@yahoo.com
authors.forename: Gabriella P
authors.initials: GP
authors.lastname: Kertesz
authors.forename: Peter
authors.initials: P
authors.lastname: Hauser
authors.forename: Peter
authors.initials: P
authors.lastname: Varga
authors.forename: Gabriella
authors.initials: G
authors.lastname: Dabasi
authors.forename: Dezso
authors.initials: D
authors.lastname: Schuler
authors.forename: Miklos
authors.initials: M
authors.lastname: Garami
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D013945:Thymoma / Q000175:diagnosis / Q000188:drug therapy*; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone; D015282:Octreotide