title: Immune reconstitution inflammatory syndrome associated with progressive multifocal leukoencephalopathy in a perinatally acquired human immunodeficiency virus-infected young adult.
abstract: Perinatally infected children represent a large proportion of the youth living with human immunodeficiency virusinfection/acquired immunodeficiency syndrome (HIV/AIDS). Because of nonadherence to treatment, an increasing number of perinatally acquired HIV-infected adolescents and young adults are showing virologic failure and immune suppression. We report a case of progressive multifocal leukoencephalopathy secondary to immune reconstitution inflammatory syndrome in a perinatally HIV-infected young adult, occurred shortly after the revision of an antiretroviral regimen. The patient showed marked improvement with the combination of corticosteroid and antiretroviral treatment.
authors.affiliation: Division of Pediatric Pulmonary, Allergy, Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA. chngto@umdnj.edu
authors.forename: Tong Wei
authors.initials: TW
authors.lastname: Ch'ng
authors.forename: Arry
authors.initials: A
authors.lastname: Dieudonne
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000821:virology*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000635:transmission / Q000821:virology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications*; D018445:Infectious Disease Transmission, Vertical; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000821:virology*
chemical_list: D019380:Anti-HIV Agents