The risk of metabolic syndrome according to the high-sensitivity C-reactive protein in apparently healthy Koreans.
BACKGROUND
Recently, considerable interest has been focused on the positive relationship between inflammation and the metabolic syndrome (MS). Therefore, we investigated whether the baseline plasma levels of the high-sensitivity C-reactive protein could be associated with future risk for MS in apparently healthy Koreans.


METHODS
A total of 1132 subjects (767 men, 365 women with a mean age of 49 years), who underwent health examination at this hospital in both 2002 and 2005 were enrolled. The criteria for metabolic syndrome followed that of NCEP-ATP III guideline except waist circumference. Instead, BMI (>/=25 kg/m(2)) was used for the measurement for obesity.


CONCLUSIONS
The relative risks of future MS in the highest quartile of high-sensitivity C-reactive protein at baseline were 2.4 (95% confidence interval [CI], 1.3-4.2) as compared to the subjects in the lowest quartile. Positive associations persisted after adjustment for age, sex and smoking; multivariate relative risks for the highest vs lowest quartiles were 2.3 (95% CI, 1.3-4.1; P for trend=0.005). This retrospective study suggests that elevated levels of high-sensitivity C-reactive protein could be associated with incident MS.
Jung
Chan-Hee
CH
Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung-dong, Seoul 110-746, South Korea.
Lee
Won-Young
WY
Kim
Se-Yeon
SY
Shin
Hun-Sub
HS
Kim
Hung Dai
HD
Rhee
Eun-Jung
EJ
Park
Chul-Young
CY
Oh
Ki-Won
KW
Park
Sung-Woo
SW
Kim
Sun-Woo
SW
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D010865:Pilot Projects; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D002097:C-Reactive Protein