Recent advances towards new anti-infective agents that inhibit cell surface protein anchoring in Staphylococcus aureus and other gram-positive pathogens.
Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.
Suree
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Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1570, USA.
Jung
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ME
Clubb
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D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D002473:Cell Wall / Q000187:drug effects / Q000201:enzymology; D003546:Cysteine Endopeptidases; D015195:Drug Design; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D013379:Substrate Specificity
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases