Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon.
Antibody responses to malaria invasion ligands and proteins on the merozoite surface have been shown to interfere with red cell invasion and correlate with immunity to malaria. The current study is the first to characterize the antibody responses to EBA-140 and EBA-181, Plasmodium falciparum invasion ligands implicated in the alternative pathways of invasion, in age-matched populations of individuals living in endemic areas in both Brazil and Cameroon. Antibody responses to the proteins screened were different between populations. The African individuals reacted strongly with most fragments of these two EBAs, while the majority of the individuals from Mato Grosso, Brazil, reacted weakly and those from the Amazon had elevated responses to these EBA proteins. When compared with the responses against MSP-1(19) and EBA-175, it appeared that the Brazilian population has a variable ability to recognize P. falciparum invasion ligand proteins and that these responses are distinct from the African population.
Ford
Louise
L
Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.
Lobo
Cheryl A
CA
Rodriguez
Marilis
M
Zalis
Mariano G
MG
Machado
Ricardo L D
RL
Rossit
Andréa R B
AR
Cavasini
Carlos E
CE
Couto
Alvaro A R
AA
Enyong
Peter A
PA
Lustigman
Sara
S
D000328:Adult; D017677:Age Distribution; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D001938:Brazil / Q000453:epidemiology; D002163:Cameroon / Q000453:epidemiology; D019353:Endemic Diseases; D005786:Gene Expression Regulation; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology / Q000378:metabolism*; D015800:Protozoan Proteins / Q000276:immunology* / Q000378:metabolism; D011994:Recombinant Proteins / Q000276:immunology
D000913:Antibodies, Protozoan; D015800:Protozoan Proteins; D011994:Recombinant Proteins