Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical findings. Shigella was more frequently isolated from cases than controls (6.7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes.
Mandomando
Inácio
I
Centro de Investigação em Saúde da Manhiça, IDIBAPS/Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. inacio.mandomando@manhica.net
Sigaúque
Betuel
B
Vallès
Xavier
X
Espasa
Mateu
M
Sanz
Sergi
S
Sacarlal
Jahit
J
Macete
Eusébio
E
Abacassamo
Fátima
F
Ruiz
Joaquim
J
Gascon
Joaquim
J
Kotloff
Karen L
KL
Levine
Myron M
MM
Alonso
Pedro L
PL
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D007223:Infant; D009073:Mozambique / Q000453:epidemiology; D012424:Rural Population; D012703:Serotyping; D012760:Shigella / Q000145:classification* / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents