CYLD: a DUB with many talents.
The deubiquitinating enzyme CYLD is a tumor suppressor protein known for its role in repression of generally pro-oncogenic NF-kappaB activation pathways. Two new studies published in this and the September issue of Developmental Cell show that CYLD dismantles distinct types of polyubiquitin chains formed on select signaling proteins and is thereby required for normal vertebrate and invertebrate development.
Simonson
Sara J S
SJS
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.
Wu
Zhao-Hui
ZH
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.
Miyamoto
Shigeki
S
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA. Electronic address: smiyamot@wisc.edu.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000502:physiology*; D000074749:Deubiquitinating Enzyme CYLD; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D025821:Polyubiquitin / Q000378:metabolism; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*
D029721:Drosophila Proteins; D016328:NF-kappa B; D025521:Tumor Suppressor Proteins; D025821:Polyubiquitin; C523258:CYLD protein, Drosophila; C511601:CYLD protein, mouse; D000074749:Deubiquitinating Enzyme CYLD; D003546:Cysteine Endopeptidases