Human mesenchymal stem cells: from basic biology to clinical applications.
Mesenchymal stem cells (MSC) are a group of clonogenic cells present among the bone marrow stroma and capable of multilineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. Due to their ease of isolation and their differentiation potential, MSC are being introduced into clinical medicine in variety of applications and through different ways of administration. Here, we discuss approaches for isolation, characterization and directing differentiation of human mesenchymal stem cells (hMSC). An update of the current clinical use of the cells is also provided.
Abdallah
B M
BM
Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital and Medical Biotechnology Centre, University of Southern Denmark, Odense, Denmark.
Kassem
M
M
D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D023822:Tissue Engineering