title: Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial.
abstract: As part of the first randomized, sham-stimulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.
authors.forename: Joerg
authors.initials: J
authors.lastname: Mueller
authors.forename: Inger M
authors.initials: IM
authors.lastname: Skogseid
authors.forename: Reiner
authors.initials: R
authors.lastname: Benecke
authors.forename: Andreas
authors.initials: A
authors.lastname: Kupsch
authors.forename: Thomas
authors.initials: T
authors.lastname: Trottenberg
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Gerd H
authors.initials: GH
authors.lastname: Schneider
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Eisner
authors.forename: Alexander
authors.initials: A
authors.lastname: Wolters
authors.forename: J U
authors.initials: JU
authors.lastname: Müller
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Marcus O
authors.initials: MO
authors.lastname: Pinsker
authors.forename: Geir K
authors.initials: GK
authors.lastname: Roeste
authors.forename: Juliane
authors.initials: J
authors.lastname: Vollmer-Haase
authors.forename: Angela
authors.initials: A
authors.lastname: Brentrup
authors.forename: Martin
authors.initials: M
authors.lastname: Krause
authors.forename: Volker
authors.initials: V
authors.lastname: Tronnier
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
authors.forename: Jüergen
authors.initials: J
authors.lastname: Voges
authors.forename: Guido
authors.initials: G
authors.lastname: Nikkhah
authors.forename: Jan
authors.initials: J
authors.lastname: Vesper
authors.forename: Markus
authors.initials: M
authors.lastname: Naumann
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D004185:Disability Evaluation; D004311:Double-Blind Method; D004421:Dystonia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010919:Placebos; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D010919:Placebos