title: Development of a multi-channel, portable optical topography system.
abstract: Optical topography (OT) based on near infrared spectroscopy (NIRS) is useful for measuring changes in the concentrations of oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) in brain tissues non-invasively. Conventional OT systems limit subjects' ranges of movement to within the length of optical fibers these systems require for irradiating light on the scalp and detecting light transmitted through the tissues in the human head. We developed a prototype of a multi-channel, portable OT system without optical fibers. We used the portable system to measure changes in the concentrations of oxy-Hb and deoxy-Hb in the frontal cortex while the subjects performed a word fluency task. The results show typical changes in hemoglobin concentrations during the task and suggest the prototype system can be used to investigate brain functions in the frontal cortex.
authors.affiliation: Advanced Research Laboratory, Hitachi, Ltd., 2520 Akanuma, Hatoyama, Saitama 350-0395, Japan. hirokazu.atsumori.et@hitachi.com
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Atsumori
authors.forename: Masashi
authors.initials: M
authors.lastname: Kiguchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Obata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.forename: Takusige
authors.initials: T
authors.lastname: Katura
authors.forename: Kei
authors.initials: K
authors.lastname: Utsugi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Funane
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maki
mesh_terms: D002540:Cerebral Cortex / Q000378:metabolism*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008904:Miniaturization; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D010092:Oximetry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation*
chemical_list: D006454:Hemoglobins