[The regulation of gene expression by glucose].
Glucose should not be considered uniquely as a cellular fuel but also as a signaling molecule involved in the regulation of genes encoding glycolytic and lipogenic enzymes and, as such, in storage of triglycerides. Transcriptional effects of glucose on glycolytic and lipogenic enzymes involve a specific transcription factor, ChREBP, whose characteristics and mechanism of activation are described. Finally, the possible implication of ChREBP in the physiopathology of obesity and type 2 diabetes are discussed.
Girard
Jean
J
INSERM U567, CNRS UMR 8104, Université Paris Descartes, Département d'Endocrinologie, Métabolisme et Cancer, Faculté de Médecine Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris. girard@cochin.inserm.fr
Dentin
Renaud
R
Benhamed
Fadila
F
Denechaud
Pierre-Damien
PD
Postic
Catherine
C
D005786:Gene Expression Regulation / Q000502:physiology*; D005947:Glucose / Q000502:physiology*; D006019:Glycolysis / Q000235:genetics; D006801:Humans; D008055:Lipids / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014280:Triglycerides / Q000502:physiology
D008055:Lipids; D014157:Transcription Factors; D014280:Triglycerides; D005947:Glucose