title: A laser Doppler system for intracerebral measurements during stereotactic neurosurgery.
abstract: A laser Doppler system for intracerebral measurements during stereotactic and functional neurosurgery is presented. The system comprises a laser Doppler perfusion monitor, an optical probe adapted for the Leksell Stereotactic System and a personal computer with software for acquisition, data analysis and presentation. The software makes it possible to present both the perfusion and the total backscattered light intensity (TLI) in real-time. During intracerebral measurements, the perfusion signal records the tissue's microcirculation whereas the TLI signal may be used to distinguish between grey and white matter. Evaluation of the system has been done during stereotactic neurosurgery in relation to implantation of deep brain stimulation electrodes. Measurements were made along trajectories towards targets in the deep brain structure as well as in pre-calculated target areas. The measurements show that the system has a potential to be used for intracerebral guidance but further evaluation of the technique is needed.
authors.affiliation: Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Wårdell
authors.forename: Carina
authors.initials: C
authors.lastname: Fors
authors.forename: Johan
authors.initials: J
authors.lastname: Antonsson
authors.forename: Ola
authors.initials: O
authors.lastname: Eriksson
mesh_terms: D001921:Brain / Q000098:blood supply / Q000601:surgery; D002560:Cerebrovascular Circulation; D004558:Electric Stimulation; D006801:Humans; D007432:Intraoperative Period; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation* / Q000379:methods*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D012984:Software; D013238:Stereotaxic Techniques / Q000295:instrumentation*