Resident cardiac mast cells: are they the major culprit in the pathogenesis of cardiac hypertrophy?
Mast cells originate from pluripotent progenitor cells in bone marrow and are major players in the inflammation process. The involvements of mast cells in various cardiovascular complications such as arrhythmias, ischaemia reperfusion injury and graft rejection are well documented. Moreover, recent studies suggest the involvement of mast cells in cardiac hypertrophy and heart failure. The present review focuses on the role of mast cells in the development of cardiac hypertrophy and heart failure.
Balakumar
Pitchai
P
ISF Institute of Pharmaceutical Sciences and Drug Research, Moga, Punjab, India. pbala2002@rediffmail.com
Singh
Amrit Pal
AP
Ganti
Subrahmanya S
SS
Krishan
Pawan
P
Ramasamy
Subbiah
S
Singh
Manjeet
M
D000818:Animals; D001685:Biological Factors / Q000378:metabolism; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D015550:Cell Degranulation / Q000502:physiology; D018450:Disease Progression; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
D001685:Biological Factors