[Blood supply of liver metastatic tumors observed by both CT arterial portography via superior mesenterica arterial and multi-slice spiral CT perfusion imaging].
OBJECTIVE
The blood supply of liver metastatic tumors affects the selection of administration approach and target vessels of interventional therapy. This study was to investigate the blood supply of liver metastatic tumors with both CT arterial portography (CTAP) via the superior mesenterica arterial (SMA) and multi-slice spiral CT perfusion imaging.


METHODS
Twenty patients with liver metastatic tumors received CTAP via SMA and multi-slice spiral CT perfusion imaging. The CT values of 33 metastatic lesions and 20 specimens of normal liver tissue from the patients were measured through the time-density curves (TDC) of region of interest (ROI). The blood flow (BF), blood volume (BV), mean transit time (MTT), capillary vessel permeability surface (PS) of the portal vein were calculated with single-blood perfusion model.


RESULTS
The diameters of the 33 metastatic lesions were 0.8-3.5 cm. The increment of CT values after enhancement was no more than 10 Hu in all lesions. At portal venous phase of SMA-digital subtraction angiography (DSA), no tumor vessel was found in the lesions. The BF, BV, MTT, and PS of the portal vein were (17.15+/-11.38) ml x min-(1) x 100 ml-(1), (1.62+/-0.97) ml x 100 g-(1), (9.47+/-2.78) s, and (3.97+/-3.44) ml x min-(1) x 100 ml-(1), respectively, in metastatic lesions, and were (133.43+/-67.17) ml x min-(1) x 100 ml-(1), (16.56+/-11.15) ml x 100 g-(1), (9.52+/-2.84) s, (35.16+/-14.03) ml x min-(1) x 100 ml-(1), respectively, in normal liver tissues. The differences in BF, BV and PS between the 2 groups were significant (P<0.001). However, the difference in MTT was not significant (P=0.96).


CONCLUSIONS
CTAP via SMA can be used to measure accurately portal venous flow. The portal vein is not involved in the blood supply of liver metastatic tumors.
Shi
Gao-Feng
GF
Department of Radiography, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050011, PR China.
Wang
Qi
Q
Li
Zhi-Gang
ZG
Wang
Shi-Jie
SJ
DU
Yu
Y
Wang
Ya-Ning
YN
D000328:Adult; D015901:Angiography, Digital Subtraction / Q000379:methods; D001810:Blood Volume; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging*; D011172:Portography / Q000379:methods*; D012039:Regional Blood Flow; D013274:Stomach Neoplasms / Q000473:pathology; D036542:Tomography, Spiral Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed