Statistical analysis of six STR loci located in MHC region in Iranian population for preimplantation genetic diagnosis.
We studied allele frequency and other statistical parameters of six short-tandem repeat (STR) loci: D6S265, D6S439, D6S105, D6S82-1, MICA, and MOGd, which are located in major histocompatibility complex (MHC) region (6p21.3) in 101 Iranian individuals. STR polymorphisms were analysed by PCR and polyacrylamide gel electrophoresis and subsequent comparison with standard (allelic) ladders. Exact tests of Hardy-Weinberg equilibrium were performed for the six loci. All loci, except the MOGd (P = 0.4291), were in Hardy-Weinberg equilibrium. These data may be useful in PGD-HLA matching and forensic science.
Korzebor
A
A
Department of Medical Genetics, Medical Sciences/Tehran University, Tehran, Iran.
Zamani
M
M
Nouri
K
K
Modarressi
M H
MH
D000483:Alleles; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D007492:Iran; D008285:Major Histocompatibility Complex / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D019836:Preimplantation Diagnosis
D005819:Genetic Markers