title: Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines.
abstract: A palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides represents a new strategy for the synthesis of benzannulated N-heterocycles, affording functionalized indolines and tetrahydroquinolines from simple precursors.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
authors.forename: Praew
authors.initials: P
authors.lastname: Thansandote
authors.forename: Manuel
authors.initials: M
authors.lastname: Raemy
authors.forename: Alena
authors.initials: A
authors.lastname: Rudolph
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006873:Hydroquinones / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D017605:Bromine Compounds; D006571:Heterocyclic Compounds; D006873:Hydroquinones; D007211:Indoles; D010165:Palladium; D002244:Carbon; D001554:Benzene; D009584:Nitrogen; C031927:hydroquinone