title: The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps.
abstract: BACKGROUND
  The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer. While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia. All in all, the relative risk of cancer based on polyp distribution in correlation with dysplasia has not been statistically studied which is done in our study.
  
  
  METHODS
  Between June 2001 and March 2004, the distribution of 130 adenomatous polyps was compared with synchronous invasive or in situ cancer. Factors such as Patient age, Patients gender, location of lesion, size of polyp, histological subtype of adenoma on biopsy, degree of dysplasia, synchronous cancer, color of polyp, and number of polyps were included in the data collection.
  
  
  RESULTS
  Multivariate logistic regression test was used to evaluate the association between malignancy and various clinical variables. It revealed histological subtype, high grade of dysplasia and size to be independent predictor of malignancy. However; left-sided location and histological subtype to be independent risk factor for high-grade dysplasia.
  
  
  CONCLUSIONS
  Lesions greater than 1 cm in diameter with high-grade dysplasia after splenic flexure should be managed as presumptive malignancies with segmental colon resection. In intermediate-risk lesions the physician should decide individually.
authors.affiliation: Azad-Tehran University of Medical Science, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Khatibzadeh
authors.forename: S A
authors.initials: SA
authors.lastname: Ziaee
authors.forename: N
authors.initials: N
authors.lastname: Rahbar
authors.forename: S
authors.initials: S
authors.lastname: Molanie
authors.forename: L
authors.initials: L
authors.lastname: Arefian
authors.forename: S A
authors.initials: SA
authors.lastname: Fanaie
mesh_terms: D018256:Adenomatous Polyps / Q000473:pathology* / Q000601:surgery; D000328:Adult; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging