title: Smallpox vaccination and ischemic coronary events in healthy adults.
abstract: Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.
authors.affiliation: Brooke Army Medical Center, Fort Sam Houston, TX, United States. robert.eckart@amedd.army.mil
authors.forename: Robert E
authors.initials: RE
authors.lastname: Eckart
authors.forename: Eric A
authors.initials: EA
authors.lastname: Shry
authors.forename: J Edwin
authors.initials: JE
authors.lastname: Atwood
authors.forename: John F
authors.initials: JF
authors.lastname: Brundage
authors.forename: Jenny C
authors.initials: JC
authors.lastname: Lay
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Bateson
authors.forename: John D
authors.initials: JD
authors.lastname: Grabenstein
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D005260:Female; D006801:Humans; D017589:Immunization Programs; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012900:Smallpox Vaccine / Q000009:adverse effects*; D014481:United States; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D012900:Smallpox Vaccine