title: High serum uric acid as a novel risk factor for type 2 diabetes.
abstract: OBJECTIVE
  To investigate the association between serum uric acid level and risk of type 2 diabetes.
  
  
  METHODS
  The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.
  
  
  RESULTS
  The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.
  
  
  CONCLUSIONS
  The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.
authors.affiliation: Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
authors.forename: Abbas
authors.initials: A
authors.lastname: Dehghan
authors.forename: Mandy
authors.initials: M
authors.lastname: van Hoek
authors.forename: Eric J G
authors.initials: EJ
authors.lastname: Sijbrands
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000150:complications*; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid