Topography-biased compound library design: the shape of things to come?
The design and synthesis of quality compound libraries is of critical importance to any pharmaceutical company that relies on high throughput screening efforts for the identification of lead compounds. In this perspective, we use a moment of inertia derived shape analysis to interrogate potential libraries for chemical synthesis. An analysis of known 'Rule of Five' compliant drug shapes using this methodology clearly highlights compound libraries that may be reasonably expected, shape wise, to interact with biologically relevant protein active site topography and those that, although being structurally diverse in shape, have little chance of being pharmacologically productive. The use of multicomponent reactions as a means of producing structurally novel, bioactive compounds in a synthetically expeditious manner is also highlighted.
Akritopoulou-Zanze
Irini
I
Medicinal Chemistry Technologies and Structural Biology, Advanced Technologies, Abbott Laboratories, Abbott Park, IL 60064, United States.
Metz
James T
JT
Djuric
Stevan W
SW
D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D008968:Molecular Conformation