Zymogen activation, inhibition, and ectodomain shedding of matriptase.
Matriptase is a member of an expanding group of type II transmembrane serine proteases. Recently, much has been learned about the biochemistry, cellular biology, normal tissue physiology, and human pathology of this protease, and of its inhibitor, termed the hepatocyte growth factor inhibitor-1 (HAI-1). This review examines the recent literature that has characterized the regulation of matriptase and HAI-1 with an emphasis on the molecular mechanisms governing its zymogen activation, inhibition by HAI-1, and ectodomain shedding.
Lin
Chen-Yong
CY
Department of Biochemistry and Molecular Biology, Greenborne Cancer Center, University of Maryland, School of Medicine, Baltimore, MD 21201, USA. cylin@som.umaryland
Tseng
I-Chu
IC
Chou
Feng-Pai
FP
Su
Sheng-Fang
SF
Chen
Ya-Wen
YW
Johnson
Michael D
MD
Dickson
Robert B
RB
D020816:Amino Acid Motifs; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D003600:Cytosol / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D011487:Protein Conformation; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry* / Q000378:metabolism; D012697:Serine Endopeptidases / Q000737:chemistry*; D013498:Suramin / Q000737:chemistry
D000911:Antibodies, Monoclonal; D008246:Lysophospholipids; D008562:Membrane Glycoproteins; D053491:Proteinase Inhibitory Proteins, Secretory; C109149:SPINT1 protein, human; D013498:Suramin; D012697:Serine Endopeptidases; C485595:matriptase