High serum uric acid as a novel risk factor for type 2 diabetes.
OBJECTIVE
To investigate the association between serum uric acid level and risk of type 2 diabetes.


METHODS
The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.


RESULTS
The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.


CONCLUSIONS
The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.
Dehghan
Abbas
A
Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
van Hoek
Mandy
M
Sijbrands
Eric J G
EJ
Hofman
Albert
A
Witteman
Jacqueline C M
JC
D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000150:complications*; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid