title: Acute hypoxia, diabetes, and neuroimmune dysregulation: converging mechanisms in the brain.
abstract: Acute hypoxia is experienced by a variety of individuals (neonates to the elderly) and in an assortment of conditions and diseases (terrorist bomb attack to decompensated heart failure). Increasingly, elaboration of inflammatory cytokines appears key to the brain-based response to hypoxia, as evidenced by the biobehaviors of malaise, fatigue, lethargy, and loss of interest in the physical and social environment. These sickness symptoms implicate hypoxia-dependent activation of the neuroimmune system as a key component of acute hypoxia. Type 2 diabetes (T2D) is associated with increased incidence, severity, and delayed recovery from hypoxic events. Why T2D negatively affects acute hypoxia is not well understood. Recent work, however, reveals that anti-inflammatory pathways tied to the interleukin (IL)-1beta arm of the neuroimmune system may be critical. In this review, the authors examine the link between acute hypoxia, T2D, and neuroimmunity.
authors.affiliation: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Johnson
authors.forename: Christina L
authors.initials: CL
authors.lastname: Sherry
authors.forename: Jason M
authors.initials: JM
authors.lastname: York
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Freund
mesh_terms: D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D004660:Encephalitis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D002534:Hypoxia, Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D053583:Interleukin-1beta / Q000276:immunology; D020738:Leptin / Q000276:immunology / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D053583:Interleukin-1beta; D020738:Leptin