Role of caspase-independent apoptosis in cardiovascular diseases.
Apoptosis plays an important role in various cardiovascular diseases, and inhibition of cardiac apoptosis shows promise as a therapeutic strategy. Caspase, a critical enzyme in the induction and execution of apoptosis, has been targeted to inhibit apoptosis. However a newly recognized caspase-independent apoptosis pathway may also play an important role in cardiac apoptosis. Yet the mechanism and the potential significance of caspase-independent apoptosis in the heart remain poorly understood. In this paper, we reviewed the literatures on the mechanism of caspase-independent apoptosis and its significance in cardiovascular diseases.
Bae
Soochan
S
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Yalamarti
Bhargavi
B
Kang
Peter M
PM
D000818:Animals; D017209:Apoptosis; D051033:Apoptosis Inducing Factor / Q000378:metabolism; D001343:Autophagy; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000473:pathology*; D020169:Caspases / Q000378:metabolism*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D017434:Protein Structure, Tertiary
D051033:Apoptosis Inducing Factor; D004791:Enzyme Inhibitors; D020169:Caspases