Urinary leukotriene E4.
Measurement of urinary leukotriene E4 (LTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene levels in specific microenvironments, such as the airway. Urinary LTE4 measurements can be used as sensitive biomarkers of exposure to asthma triggers, such as air pollution and viral infections. Recent studies suggest the potential of using urinary LTE4 concentrations as predictors of asthma control and markers of susceptibility to treatment with leukotriene receptor antagonists.
Rabinovitch
Nathan
N
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. rabinovitchn@njc.org
D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000652:urine; D015415:Biomarkers; D005541:Forced Expiratory Volume; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D017999:Leukotriene E4 / Q000652:urine*; D008565:Membrane Proteins / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000378:metabolism
D015415:Biomarkers; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; D017999:Leukotriene E4; C083169:leukotriene D4 receptor