title: Impact of terlipressin on renal graft function.
abstract: To assess the effect of a bolus of terlipressin in brain-dead donors with shock refractory to norepinephrine, a retrospective study was conducted in a 16-bed intensive care unit of a university hospital. Twenty brain-dead donors were treated with norepinephrine within the study period. Nine of these donors developed persisting hypotension (MAP < 65 mmHg) not responding to fluid loading and high dose of norepinephrine. They were then treated with a single bolus of terlipressin (1 mg). This resulted in a MAP rise from 58 +/- 10 to 93 +/- 20 mmHg (P = 0.009). One month after transplantation, no differences were observed in serum creatinine levels of the recipients who received a renal transplant extracted from donors responding or not to norepinephrine (138 +/- 43 vs. 137 +/- 43 microM; P = 0.95). The liver function was similar in both groups. Within the limitations of this study, a single bolus of terlipressin in norepinephrine-resistant vasodilatory shock donors does not affect the renal and liver graft quality in the recipients.
authors.affiliation: Département d'Anesthésie et de Réanimation, Hôpital Nord, Marseille, France.
authors.forename: Valéry
authors.initials: V
authors.lastname: Blasco
authors.forename: Marc
authors.initials: M
authors.lastname: Leone
authors.forename: Alain
authors.initials: A
authors.lastname: Geissler
authors.forename: François
authors.initials: F
authors.lastname: Antonini
authors.forename: Jacques
authors.initials: J
authors.lastname: Albanèse
authors.forename: Claude
authors.initials: C
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001926:Brain Death / Q000097:blood / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000097:blood / Q000139:chemically induced; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D016030:Kidney Transplantation; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008236:Lypressin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage / Q000009:adverse effects; D020127:Recovery of Function / Q000187:drug effects*; D012189:Retrospective Studies; D012769:Shock / Q000097:blood / Q000139:chemically induced; D000077585:Terlipressin; D014184:Transplantation, Homologous
chemical_list: D000959:Antihypertensive Agents; D008236:Lypressin; D000077585:Terlipressin; D003404:Creatinine; D009638:Norepinephrine