title: PCB/polymer based micro-fluidic system for NMR spectroscopy for nanoliters sample volume.
abstract: In this work, we report on the realization of an innovating micro system for NMR spectroscopy on small sample volume (30-100 nL). We propose a micro system based on Printed Circuit Board (PCB) technology for the NMR probe associated to a micro fluidic system made with polymer (COC). The comparison of several samples during the same NMR experiments could provide more precise information. In that context, we have realized a micro-fluidic system with two cavities, each cavity presenting a volume of 37 nl. The fabrication process is described, and first results are reported. The tight sealing of the micro-fluidic system has been demonstrated and preliminary NMR experiment results are presented.
authors.affiliation: Institut des Nanotechnologies de Lyon (INL), University Claude Bernard, Villeurbanne, 69622 France. guillaume.pasquet@univ-lyon1.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Pasquet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Chateaux
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Deman
authors.forename: Bernard
authors.initials: B
authors.lastname: Fenet
authors.forename: Pierre
authors.initials: P
authors.lastname: Morin
mesh_terms: D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D008280:Magnetics / Q000295:instrumentation*; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D011076:Polycarboxylate Cement / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000295:instrumentation* / Q000379:methods; D014159:Transducers
chemical_list: D011076:Polycarboxylate Cement; C005506:polycarbonate