title: Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.
abstract: The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo. Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE-antigen complex, with IC(50) values of 45 and 55 muM, respectively, but also inhibited the protein expressions of IL-4 and TNF-alpha. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases.
authors.affiliation: Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun-Ku, Seoul, Korea.
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Han
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Bae
authors.forename: Hien Trung
authors.initials: HT
authors.lastname: Trinh
authors.forename: Jung-Hwa
authors.initials: JH
authors.lastname: Yang
authors.forename: Ui-Jung
authors.initials: UJ
authors.lastname: Youn
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Bae
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E / Q000276:immunology; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D018926:Anti-Allergic Agents; D001713:Biphenyl Compounds; D007073:Immunoglobulin E; D017705:Lignans; D001619:beta-N-Acetylhexosaminidases; D003189:p-Methoxy-N-methylphenethylamine; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols