CD40-induced countercurrent conduits for tumor escape or elimination?
CD40--which is expressed on endothelial cells and antigen-presenting cells, such as B cells, macrophages and dendritic cells--is a glycoprotein receptor for T cell-expressed CD40-ligand. CD40 signaling leads to production of both pro-inflammatory and anti-inflammatory mediators. Some of these mediators, such as vascular endothelial growth factor, help in angiogenesis, forming new capillaries. Although these capillaries can function as conduits for tumor-cell metastasis, these same vessels can also be a gateway for entry of activated anti-tumor effector cells that eliminate tumors. How such countercurrent processes can be turned in favor of anti-tumor immunity remains to be shown.
Murugaiyan
Gopal
G
National Centre for Cell Science, Ganeshkhind, Pune 411007, India.
Martin
Sunil
S
Saha
Bhaskar
B
D042682:Angiopoietins / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism*; D019013:CD40 Antigens / Q000276:immunology / Q000378:metabolism*; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D042783:Endothelial Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D019139:Tumor Escape; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology / Q000378:metabolism*
D042682:Angiopoietins; D019013:CD40 Antigens; D018925:Chemokines; D042461:Vascular Endothelial Growth Factor A