title: B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
abstract: B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-gamma-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-gamma and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-gamma production during the effector phase of allergic asthma.
authors.affiliation: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Miyuki
authors.initials: M
authors.lastname: Eguchi-Tsuda
authors.forename: Takako
authors.initials: T
authors.lastname: Nakano
authors.forename: Takafumi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Mikiko
authors.initials: M
authors.lastname: Matsumura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Moriwaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Kan-o
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Hideo
authors.initials: H
authors.lastname: Yagita
authors.forename: Tahiro
authors.initials: T
authors.lastname: Shin
authors.forename: Drew M
authors.initials: DM
authors.lastname: Pardoll
authors.forename: Rirprajak
authors.initials: R
authors.lastname: Patcharee
authors.forename: Miyuki
authors.initials: M
authors.lastname: Azuma
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D018122:B7-1 Antigen / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism; D015536:Down-Regulation; D025461:Feedback, Physiological; D006967:Hypersensitivity / Q000276:immunology*; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D018793:Interleukin-13 / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D010641:Phenotype; D061027:Programmed Cell Death 1 Ligand 2 Protein; D015854:Up-Regulation
chemical_list: D018122:B7-1 Antigen; D018793:Interleukin-13; C556978:Pdcd1lg2 protein, mouse; D061027:Programmed Cell Death 1 Ligand 2 Protein; D007371:Interferon-gamma