[Create mathematical model and analysis of correlation between Chinese medicinal characteristics and immunoregulatory activity based on literature informatics].
OBJECTIVE
Intends to create mathematical model and analysis of correlation between Chinese medicinal characteristics and immunoregulatory activity based on literature informatics.


METHODS
The numbers of the Chinese medicines with immune effects were worked out within the framework of "The China Pharmacopeia" of 2005 edition, from the literature publicized since 1980. The correlation and mathematical model were figured out between Chinese medicinal characteristics including biological classification, different tastes, channel tropism as well as the parts used and immunoregulatory activity based on the statistical software SPSS.


RESULTS
The results showed that the immunoregulatory activity was related to the five tastes of Chinese medicines, and the pungent medicines had less immune effect. The Chinese medicines of underground parts had more immune effect compared with other parts of the medicine. Medicines acting upon heart and kidneys were more powerful as for the immune effects (P <0.05). The coincidence was 74.7% between mathematical computing and original classification.


CONCLUSIONS
There are correlations,between Chinese medicinal characteristics and immunoregulatory activity. The mathematical model based on these results can be used for immunopharmacology.
Li
Yan-ju
YJ
Department of Clinic Immunology, Dalian Medical University, Dalian 116027, China.
Liu
Hui
H
Wang
Hong-fei
HF
Guo
Yue-qiu
YQ
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D016208:Databases, Factual; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D008962:Models, Theoretical; D010946:Plants, Medicinal / Q000737:chemistry / Q000145:classification
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal