106Ru radiolabelling of the antitumour complex [(eta6-fluorene)Ru(en)Cl]PF6.
The organometallic half-sandwich Ru(II) arene anticancer complex [(eta(6)-fluorene)Ru(en)Cl]PF(6) () has been synthesized in high yield and purity on a micromole scale with incorporation of the beta-emitting radioisotope (106)Ru (half-life = 1.01 y) using a refined procedure involving conversion of RuCl(3) into [(eta(6)-fluorene)RuCl(2)](2), and then [(eta(6)-fluorene)Ru(CH(3)CN)(2)Cl]PF(6) as intermediates. Distribution studies 0.25 h post i.v. injection of (106)Ru- at a dose of 25 mg kg(-1) show that (106)Ru is well distributed throughout the tissues of a rat. This appears to be the first report of the radiolabelling of a potential ruthenium antitumour agent for distribution/biological studies.
Hoeschele
James D
JD
Chemistry Department, Michigan State University, E. Lansing, MI 48824-1322, USA.
Habtemariam
Abraha
A
Muir
Jeanette
J
Sadler
Peter J
PJ
D000970:Antineoplastic Agents / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000737:chemistry*; D012588:Scintillation Counting; D013057:Spectrum Analysis / Q000379:methods
D000970:Antineoplastic Agents; D005449:Fluorenes; D011868:Radioisotopes; D017975:Ruthenium Compounds; C041509:fluorene