title: Clinical trial: sodium phosphate tablets are preferred and better tolerated by patients compared to polyethylene glycol solution plus bisacodyl tablets for bowel preparation.
abstract: BACKGROUND
  Patient acceptance of bowel preparation can affect colon cancer screening compliance. Aim To compare patient acceptance, preference and tolerability of 32-sodium phosphate tablets vs. 2L polyethylene glycol solution plus 4 bisacodyl tablets for bowel preparation.
  
  
  METHODS
  A prospective, randomized, investigator-blinded, multicentre trial was performed. Results were based on responses to a patient questionnaire.
  
  
  RESULTS
  411 patients (205 sodium phosphate; 206 polyethylene glycol plus bisacodyl) completed the study preparation and patient questionnaire prior to colonoscopy. More patients receiving sodium phosphate vs. polyethylene glycol plus bisacodyl found it easy to take (77% vs. 42%), reported it to be without taste (47% vs. 6%), found it easy to take with respect to volume of liquid prescribed (72% vs. 27%) and indicated they would take the same preparation again in the future (96% vs. 74%, P < 0.0001 for all). Fewer patients receiving sodium phosphate vs. polyethylene glycol plus bisacodyl had to take time off work or change ordinary activities to take the study preparation (18% vs. 52%, P < 0.0001). Nausea, vomiting, bloating and abdominal pain were reported less frequently with sodium phosphate (P < 0.0013).
  
  
  CONCLUSIONS
  The 32-tablet sodium phosphate dosing regimen was easier to take and better tolerated, when compared to 2L polyethylene glycol plus bisacodyl tablets for bowel preparation.
authors.affiliation: University of Pennsylvania, Gastroenterology Division, Philadelphia, PA 19104-4283, USA. grl@uphs.upenn.edu
authors.forename: G R
authors.initials: GR
authors.lastname: Lichtenstein
authors.forename: N
authors.initials: N
authors.lastname: Grandhi
authors.forename: M
authors.initials: M
authors.lastname: Schmalz
authors.forename: S R
authors.initials: SR
authors.lastname: Lottes
authors.forename: W P
authors.initials: WP
authors.lastname: Forbes
authors.forename: K
authors.initials: K
authors.lastname: Walker
authors.forename: B
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001726:Bisacodyl / Q000008:administration & dosage* / Q000009:adverse effects; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003108:Colonic Diseases / Q000601:surgery; D003113:Colonoscopy / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010710:Phosphates / Q000008:administration & dosage* / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011300:Preoperative Care / Q000379:methods; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D004337:Drug Carriers; D010710:Phosphates; D001726:Bisacodyl; D011092:Polyethylene Glycols; C018279:sodium phosphate