title: A dynamical model on the network of p53-Mdm2 feedback loop regulated by p14/19ARF.
abstract: Base on new experimental results, we give a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARF. The oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors among p53, Mdm2 and P14/19ARF. The dynamical model and its numerical results will help us understand the oscillatory behavior among other network of different proteins.
authors.affiliation: School of Science, Hebei University of Technology, Tianjin, China. lhcell@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Ying-Rong
authors.initials: YR
authors.lastname: Han
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhan
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Chen
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Tong-Jun
authors.initials: TJ
authors.lastname: Zhao
authors.forename: Yi-Zhong
authors.initials: YZ
authors.lastname: Zhuo
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2