title: [Endoscopic, clinicopathologic and immunohistochemical features of gastric stromal tumor].
abstract: OBJECTIVE
  For gastric stromal tumor (GST), the low incidence and high diversity in endoscopic and pathologic manifestations lead to misdiagnosis. This study was to explore the features of GST in endoscopy and clinicopathology.
  
  
  METHODS
  Clinical data of 42 GST patients, treated at the Second Affiliated Hospital of Sun Yat-sen University from Jan. 1996 to Jan. 2006, were analyzed for their clinicopathologic and endoscopic features. The expression of CD117, CD34, smooth muscle actin (SMA), Desmin and S-100 were detected by immunohistochemistry. Their correlations to clinicopathologic features of GST were analyzed.
  
  
  RESULTS
  Of the 42 cases of GST, 21 (50.0%) were at the fundus, 14 (33.3%) at the body, and 7 (16.7%) at the antrum; 17 (40.5%) were benign, 14 (33.3%) borderline, 11 (26.2%) malignant. Endoscopically, GST presented submucosal hemispheroid or polypoid protuberant lesions with clear border. While the positive rate of gastroendoscopic biopsy was low. Of the 42 cases, 29 were spindle cell type, 5 were epithelial cell type, and 8 were mixed type. The positive rates of CD34 and CD117 were 92.86% and 78.57%.
  
  
  CONCLUSIONS
  GST has unique morphologic features. Combined detection of CD117 and CD34 benefits the diagnosis of GST.
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China. huangkaih@21cn.com
authors.forename: Kai-Hong
authors.initials: KH
authors.lastname: Huang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Ling-Yun
authors.initials: LY
authors.lastname: Wang
authors.forename: Lian-Yuan
authors.initials: LY
authors.lastname: Wang
authors.forename: Chu-Qiang
authors.initials: CQ
authors.lastname: Li
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Zhu
authors.forename: Hai-Gang
authors.initials: HG
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018952:Antigens, CD34; D019009:Proto-Oncogene Proteins c-kit