Role of dendritic cells and chemokines in acute graft-versus-host disease.
Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. GVHD is caused by donor T cells that recognize and react to recipient histocompatibility differences, resulting in significant morbidity and mortality. The pathophysiology of GVHD is complex, which occurs in three phases: induction phase, activation phase and effector phase. Numerous studies have demonstrated that GVHD involves multiple inflammatory cells and cytokines, in particular of antigen presenting cells, chemokines and T cell subsets. This review will discuss roles of a special antigen presenting cell: dendritic cell and chemokines in T cell-mediated acute GVHD.
Xu
Jingwei
J
Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhou
Tong
T
Zhang
Yanyun
Y
D000208:Acute Disease; D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology; D002454:Cell Differentiation; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology* / Q000378:metabolism; D006086:Graft vs Host Disease / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D022423:Myeloid Cells / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D019172:Transplantation Conditioning
D018925:Chemokines