Synthetic libraries of tyrosine-derived bacterial metabolites.
The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in Escherichia coli, is reported. The synthetic libraries of N-acyl tyrosines and their 3-keto counterparts were prepared via solid-phase routes, whereas the enamides and enol esters were synthesized in solution-phase.
Georgiades
Savvas N
SN
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Clardy
Jon
J
D000438:Alcohols / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D004952:Esters / Q000737:chemistry; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry*
D000438:Alcohols; D000475:Alkenes; D000577:Amides; D004952:Esters; D054852:Small Molecule Libraries; D014443:Tyrosine