title: [Mitochondrial encephalomyoneuropathy. Case report].
abstract: Mitochondrial myopathies and encephalomyopathies constitute a group of degenerative disorders characterized by a striking degree of clinical, biochemical and genetic heterogenity. We present a case of a 42-year old woman with clinical, electrophysiological and laboratory features of a mitochondrial encephalomyoneuropathy. A muscle biopsy specimen showed ragged-red fibres. Signs of demyelination and remyelination of a few fibers were observed in a sural nerve biopsy specimen. MR imaging revealed symmetrical multifocal white matter lesions predominantly in the parieto-occipital region. We stress the benefitial therapeutic effect of CoQ since it resulted in marked alleviation of some signs of the disease.
authors.forename: S
authors.initials: S
authors.lastname: Pavlović
authors.forename: V
authors.initials: V
authors.lastname: Kostić
authors.forename: D
authors.initials: D
authors.lastname: Cvetković
authors.forename: R
authors.initials: R
authors.lastname: Trikić
authors.forename: G
authors.initials: G
authors.lastname: Dragutinović
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017237:Mitochondrial Encephalomyopathies / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D014451:Ubiquinone / Q000627:therapeutic use
chemical_list: D014451:Ubiquinone