title: Primary Ewing's sarcoma family tumors of the lung a case report and review of the literature.
abstract: Ewing's sarcoma family tumors (ESFT) have been reported to originate in a variety of sites, most commonly in the extremities. We herein report a case of a primary ESFT of the lung presenting in an 8-year-old boy. A histological examination of hematoxylin-eosin stained sections showed a homogeneous population of closely packed small neoplastic cells. The tumor cells were strongly positive for CD99/MIC2 and negative for the leukocyte common antigen, myoglobin, desmin, epithelial membrane antigen, AE1/AE3 and synaptophysin. The patient was treated with neoadjuvant chemotherapy and surgery. Nine months later, he is in good condition and chest CT scans have revealed no evidence of either local recurrence or distant metastasis. Cases of ESFT of the lung have been reported in recent years but there are still few reports of primary ESFT of the lung. To date, only eight cases of ESFT of the lung have been reported in the literature. This is the first report of an ESFT of the lung occurring in a patient under 10 years of age. The clinical course and therapeutic management of ESFT are also discussed.
authors.affiliation: Section of Pediatrics, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Nagayama
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nagatoshi
authors.forename: Jiro
authors.initials: J
authors.lastname: Inagaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yokoyama
authors.forename: Yosio
authors.initials: Y
authors.lastname: Moriyasu
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Jun
authors.initials: J
authors.lastname: Okamura
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002648:Child; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D011859:Radiography; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules