Efficacy of bovine herpesvirus-1 inactivated vaccine against abortion and stillbirth in pregnant heifers.
OBJECTIVE
To evaluate the efficacy of an inactivated bovine herpesvirus-1 (BHV-1) vaccine to protect against BHV-1 challenge-induced abortion and stillbirth.


METHODS
Prospective study.


METHODS
35 beef heifers.


METHODS
Before breeding, heifers were vaccinated with a commercially available BHV-1 inactivated vaccine SC or IM. The estrous cycle was then synchronized, and heifers were artificially inseminated 30 to 60 days after vaccination. Heifers (n = 21) were challenge inoculated IV at approximately 180 days of gestation with virulent BHV-1. Fourteen control heifers were not vaccinated. Clinical signs of BHV-1 infection were monitored for 10 days following challenge; serologic status and occurrence of abortion or stillbirth were evaluated until time of calving.


RESULTS
18 of 21 (85.7%) heifers that received vaccine were protected from abortion following challenge, whereas all 14 control heifers aborted.


CONCLUSIONS
Results indicated that an inactivated BHV-1 vaccine can protect against abortion resulting from a substantial challenge infection, with efficacy similar to that of modified-live BHV-1 vaccines.
Zimmerman
Alicia D
AD
Rural Technologies Inc, 1008 32nd Ave, Brookings, SD 57006, USA.
Buterbaugh
Robin E
RE
Herbert
John M
JM
Hass
Jamie M
JM
Frank
Nicole E
NE
Luempert Iii
Louis G
LG
Chase
Christopher C L
CC
D000034:Abortion, Veterinary / Q000517:prevention & control*; D000818:Animals; D002417:Cattle; D005260:Female; D005313:Fetal Death / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007241:Infectious Bovine Rhinotracheitis / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary*; D011446:Prospective Studies; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines