title: [Accelerated partial breast irradiation: a concept to individualize treatment in breast cancer].
abstract: Whole breast irradiation delivering an equivalent dose of 50 Gy in 5 weeks, followed by a 10 to 16 Gy-boost to the tumor bed is the standard of care after breast-conserving surgery for early-breast cancer. Accelerated partial breast irradiation (APBI) is currently under investigations in large multi-institutional, prospective, randomized trials to objectively address the critical endpoints of treatment efficacy, toxicity and cosmesis. Patient's selection for this new approach is crucial to individualise treatments and define the subgroups of patients who will really benefit from APBI in terms of quality of life without decreasing long-term results of the disease control and cosmesis. In this review, we will discuss the patients' profiles selection for APBI regarding their general and tumor criteria. The differences between APBI techniques either performed intra or post operatively will be also discussed.
authors.affiliation: Département de Radiothérapie, Centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020, Lille, France. y-belkacemi@o-lambret.fr
authors.forename: Y
authors.initials: Y
authors.lastname: Belkacémi
authors.forename: B
authors.initials: B
authors.lastname: Comet
authors.forename: J-M
authors.initials: JM
authors.lastname: Hannoun-Levi
authors.forename: S
authors.initials: S
authors.lastname: Villette
authors.forename: H
authors.initials: H
authors.lastname: Marsiglia
authors.forename: M
authors.initials: M
authors.lastname: Leblanc-Onfroy
authors.forename: B
authors.initials: B
authors.lastname: Delalande
authors.forename: D
authors.initials: D
authors.lastname: Azria
authors.forename: J-B
authors.initials: JB
authors.lastname: Dubois
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018579:Patient Selection; D011182:Postoperative Care; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors