title: Articular cartilage regeneration with microfracture and hyaluronic acid.
abstract: Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-beta3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.
authors.affiliation: Department of Chemical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Sun-Woong
authors.initials: SW
authors.lastname: Kang
authors.forename: Leela Prasad
authors.initials: LP
authors.lastname: Bada
authors.forename: Chang-Seok
authors.initials: CS
authors.lastname: Kang
authors.forename: Jae-Sun
authors.initials: JS
authors.lastname: Lee
authors.forename: Chul-Hwan
authors.initials: CH
authors.lastname: Kim
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D054544:Arthroplasty, Subchondral; D002358:Cartilage, Articular / Q000166:cytology / Q000502:physiology*; D005782:Gels; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D011817:Rabbits; D012038:Regeneration; D053782:Transforming Growth Factor beta3 / Q000494:pharmacology*
chemical_list: D005782:Gels; D053782:Transforming Growth Factor beta3; D006820:Hyaluronic Acid