title: Chronic myeloid leukemia associated with mitoxantrone treatment in a patient with MS.
abstract: We report the first case of chronic myeloid leukemia (CML) in a patient with multiple sclerosis (MS) diagnosed within two years of receiving mitoxantrone therapy. Previously only acute forms of leukemia particularly acute promyelocytic leukemia (APL) have been associated with mitoxantrone treatment in MS. This underscores the need for only using mitoxantrone in severe treatment-unresponsive cases of MS.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, NY, USA. ssadiq@msrcny.org
authors.forename: Saud A
authors.initials: SA
authors.lastname: Sadiq
authors.forename: Mustapha
authors.initials: M
authors.lastname: Rammal
authors.forename: Gabriel
authors.initials: G
authors.lastname: Sara
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000139:chemically induced*; D008942:Mitoxantrone / Q000009:adverse effects*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008942:Mitoxantrone