title: Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs.
abstract: A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.
authors.affiliation: Department of Chemistry, University of Leeds, Leeds, UK LS2 9 JT.
authors.forename: Olivia R
authors.initials: OR
authors.lastname: Allen
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Gott
authors.forename: John A
authors.initials: JA
authors.lastname: Hartley
authors.forename: Janet M
authors.initials: JM
authors.lastname: Hartley
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Knox
authors.forename: Patrick C
authors.initials: PC
authors.lastname: McGowan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D008958:Models, Molecular; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014025:Titanium