title: A highly stereoselective TMSOTf-mediated catalytic carbocupration of alkynoates.
abstract: The TMSOTf-mediated catalytic carbocupration of ynoates has been investigated. It has been shown that catalyst loadings as low as 5 mol % readily allow for high yields and diastereoselectivities for a series of aromatic Grignard reagents. In addition, we have been successful in vicinally functionalizing 1a via initial TMSOTf-mediated catalytic carbocupration followed by a secondary electrophilic capture of the TMS allenoate intermediate.
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, USA.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Mueller
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jennings