iNOS expression in oral and gastrointestinal tract mucosa.
It is known that the overproduction of nitric oxide (NO) by nitric oxide synthase (NOS) occurs during the progression of various inflammatory diseases in intestinal tract. NOS inhibitors or inducible nitric oxide synthase (iNOS) gene expression inhibitors should be considered as potential anti-inflammatory agents, as NO synthesized by iNOS is related to various pathophysiological processes including inflammation. In order to understand the relationship between iNOS and pathological reactions such as the inflammatory process and malign transformation clearly, the existence and amount of constitutive expression should be determined. It is crucial to comprehend the harmful and protective amounts of iNOS expressions in order to clarify the relationship between iNOS and pathological processes. Evidently, only after this inspection is it possible to utilize iNOS as a marker and treatment instrument during the diagnosis and treatment of malign transformation and the inflammatory process.
Keklikoglu
Nurullah
N
Faculty of Dentistry, Department of Histology and Embryology, Istanbul University, Capa, Istanbul, Turkey. nkeklik@istanbul.edu.tr
Koray
Meltem
M
Kocaelli
Humeyra
H
Akinci
Sevtap
S
D000818:Animals; D005767:Gastrointestinal Diseases / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000201:enzymology*; D009061:Mouth Mucosa / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology / Q000503:physiopathology
D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II