[The role and significance of integrins as cell surface receptors].
Integrins are transmembrane glycoproteins occurring in cell membranes as hetorodimers made of two subunits, alpha and beta, associated with noncovalent bonds. Ligands of these receptors are several proteins from the interstitial tissue as well as adhesive proteins from the surface of neighbouring cells. Linking of the corresponding ligands to different integrins influence the adhesion but also the functional state of the cell with these integrins. The paper deals with basic properties of integrins as cell receptors, division into the main subgroups as well as a review of adhesive proteins, important for integrin function. The important role of integrin function in some pathologic states is emphasized.
Ivić
M A
MA
Bogićević
M
M
Stefanović
V
V
D000818:Animals; D002448:Cell Adhesion; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D011956:Receptors, Cell Surface
D016023:Integrins; D011956:Receptors, Cell Surface