title: Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training.
abstract: Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: Hu
authors.initials: H
authors.lastname: Huang
authors.forename: Kaoruko
authors.initials: K
authors.lastname: Tada Iida
authors.forename: Haruka
authors.initials: H
authors.lastname: Murakami
authors.forename: Yoko
authors.initials: Y
authors.lastname: Saito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otsuki
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Iemitsu
authors.forename: Seiji
authors.initials: S
authors.lastname: Maeda
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuno
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ajisaka
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000097:blood / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002784:Cholesterol; D004247:DNA; D006442:Glycated Hemoglobin; D007328:Insulin; D014280:Triglycerides