Apigenin (4',5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice.
The potential of apigenin (4',5,7-trihydroxyflavone) in regulating hyperglycaemia, thyroid dysfunction and lipid peroxidation (LPO) has been revealed. While in alloxan-treated diabetic animals, a significant decrease in the concentrations of serum insulin, thyroxine (T(4)) and triiodothyronine (T(3)), with a parallel increase in serum glucose and hepatic glucose-6-phospatase (G-6-Pase) activity, was observed, administration of 0.78 mg kg(-1) of apigenin for 10 consecutive days increased the levels of serum insulin and thyroid hormones with a parallel decrease in glucose concentration and hepatic G-6-Pase activity. Alloxan-induced elevation in serum cholesterol was also reduced by the compound. With respect to LPO, while in alloxan-treated animals an increase in hepatic LPO and a decrease in the activity of cellular antioxidants, such as catalase (CAT) and superoxide dismutase (SOD), and in glutathione (GSH) content was observed, administration of apigenin to alloxan-treated mice reversed all these changes, suggesting its hepatoprotective potential. Similar effects of apigenin were also observed in most of the parameters in normoglycaemic animals. It appears that apigenin has a potential to regulate diabetes mellitus, as well as disease-induced thyroid dysfunction and lipid peroxidation.
Panda
Sunanda
S
Thyroid Research Laboratory, School of Life Sciences, Devi Ahilya University, Takhshila Campus, Khandwa Road, Indore-452 017, M.P., India. drsunandakar@yahoo.co.in
Kar
Anand
A
D000496:Alloxan; D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000503:physiopathology; D005419:Flavonoids / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013974:Thyroxine / Q000097:blood / Q000187:drug effects; D014284:Triiodothyronine / Q000097:blood / Q000187:drug effects
D001786:Blood Glucose; D005419:Flavonoids; D007328:Insulin; D014284:Triiodothyronine; D000496:Alloxan; D047310:Apigenin; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D005952:Glucose-6-Phosphatase; D005978:Glutathione; D013974:Thyroxine