Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients.
OBJECTIVE
To investigate the effect of cardiac output and liver blood flow on propofol concentrations in critically ill patients in the intensive care unit.


METHODS
Five medical/surgical critically ill patients were enrolled in this preliminary study. Liver blood flow was measured using sorbitol. The cardiac output was measured by bolus thermodilution. NONMEM ver. V was applied for propofol pharmacokinetic analysis.


RESULTS
The clearance of propofol was positively influenced by the liver blood flow (P < 0.005), whereas no significant correlation between cardiac output and propofol clearance was found. A correlation between liver blood flow and cardiac output or cardiac index could not be assumed in this patient group.


CONCLUSIONS
Liver blood flow is a more predictive indicator than cardiac output for propofol clearance in critically ill patients when the techniques of hepatic sorbitol clearance and bolus thermodilution, respectively, are used. Further study is needed to determine the role played by liver blood flow and cardiac output on the pharmacokinetics of highly extracted drugs in order to reduce the observed high interindividual variabilities in response in critically ill patients.
Peeters
Mariska Y M
MY
Department of Clinical Pharmacy, St. Antonius Hospital, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands.
Aarts
Leon P H J
LP
Boom
Ferenc A
FA
Bras
Leo J
LJ
Tibboel
Dick
D
Danhof
Meindert
M
Knibbe
Catherijne A J
CA
D000368:Aged; D000777:Anesthetics / Q000493:pharmacokinetics*; D002302:Cardiac Output; D016638:Critical Illness; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010865:Pilot Projects; D015742:Propofol / Q000493:pharmacokinetics*; D012984:Software; D013012:Sorbitol / Q000493:pharmacokinetics; D013815:Thermodilution
D000777:Anesthetics; D013012:Sorbitol; D015742:Propofol