[Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis].
In recent years, bone quality is thought to be an important factor in bone strength. Vitamin K(2) (VK(2))drugs inhibit bone fracture, although their effect of increasing bone mineral density (BMD)is lower compared to bisphosphonate. This suggests VK(2) analogs improve bone quality. Glucocorticoid-induced osteoporosis(GIOP)brings about a bone fracture even under the condition of high BMD. VK(2) drugs might be effective to prevent bone fracture in GIOP, because they increase bone strength independently of bone mineral density (BMD).
Tanaka
Ikuko
I
Fujita Health University, Department of Clinical and Laboratory Medicine.
Oshima
Hisaji
H
D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D024482:Vitamin K 2 / Q000494:pharmacology / Q000627:therapeutic use*
D005938:Glucocorticoids; D024482:Vitamin K 2