title: Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique.
abstract: Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical findings. Shigella was more frequently isolated from cases than controls (6.7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes.
authors.affiliation: Centro de Investigação em Saúde da Manhiça, IDIBAPS/Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. inacio.mandomando@manhica.net
authors.forename: Inácio
authors.initials: I
authors.lastname: Mandomando
authors.forename: Betuel
authors.initials: B
authors.lastname: Sigaúque
authors.forename: Xavier
authors.initials: X
authors.lastname: Vallès
authors.forename: Mateu
authors.initials: M
authors.lastname: Espasa
authors.forename: Sergi
authors.initials: S
authors.lastname: Sanz
authors.forename: Jahit
authors.initials: J
authors.lastname: Sacarlal
authors.forename: Eusébio
authors.initials: E
authors.lastname: Macete
authors.forename: Fátima
authors.initials: F
authors.lastname: Abacassamo
authors.forename: Joaquim
authors.initials: J
authors.lastname: Ruiz
authors.forename: Joaquim
authors.initials: J
authors.lastname: Gascon
authors.forename: Karen L
authors.initials: KL
authors.lastname: Kotloff
authors.forename: Myron M
authors.initials: MM
authors.lastname: Levine
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Alonso
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D007223:Infant; D009073:Mozambique / Q000453:epidemiology; D012424:Rural Population; D012703:Serotyping; D012760:Shigella / Q000145:classification* / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents