Isotopic labeling for determination of enantiomeric purity by 2H NMR spectroscopy.
The use of 2H NMR spectroscopy as a tool for the analysis of enantiomeric purity is reported. Enantiopure isotopically chiral substrates bearing a monodeuterated methylene unit were prepared; introduction of an additional asymmetric center leads to diastereomers which can be distinguished by 2H NMR on a standard spectrometer. The assays allow for simple semiquantitative analysis of asymmetric transformations.
Jackman
Hayley
H
School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.
Marsden
Stephen P
SP
Shapland
Peter
P
Barrett
Simon
S
D000475:Alkenes / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D007554:Isotopes; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D011522:Protons; D013237:Stereoisomerism
D000475:Alkenes; D007554:Isotopes; D007659:Ketones; D011522:Protons