title: Generalized linear mixed models: a review and some extensions.
abstract: Breslow and Clayton (J Am Stat Assoc 88:9-25,1993) was, and still is, a highly influential paper mobilizing the use of generalized linear mixed models in epidemiology and a wide variety of fields. An important aspect is the feasibility in implementation through the ready availability of related software in SAS (SAS Institute, PROC GLIMMIX, SAS Institute Inc., URL http://www.sas.com , 2007), S-plus (Insightful Corporation, S-PLUS 8, Insightful Corporation, Seattle, WA, URL http://www.insightful.com , 2007), and R (R Development Core Team, R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, Austria, URL http://www.R-project.org , 2006) for example, facilitating its broad usage. This paper reviews background to generalized linear mixed models and the inferential techniques which have been developed for them. To provide the reader with a flavor of the utility and wide applicability of this fundamental methodology we consider a few extensions including additive models, models for zero-heavy data, and models accommodating latent clusters.
authors.affiliation: Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada V5A 1S6. dean@stat.sfu.ca
authors.forename: C B
authors.initials: CB
authors.lastname: Dean
authors.forename: Jason D
authors.initials: JD
authors.lastname: Nielsen
mesh_terms: D004812:Epidemiologic Methods; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D012984:Software