A green GEM: intriguing analogies with animal geminin.
The transition of precursor cells from an undifferentiated proliferative state to differentiated cells with specific fates is of primary importance for multicellular organisms. Animals and plants have evolved two unrelated proteins, geminin and GEM, respectively, that play analogous roles in regulating this transition. These proteins are involved, probably in early G1 phase of the cell cycle, in regulating the expression of genes involved in cell fate and initiation of differentiation. They also interact with Cdt1, a component of the pre-replication complexes involved in DNA replication licensing in early G1 phase. The interaction of geminin and GEM with Cdt1 and transcriptional regulators is competitive, suggesting that these interactions can play a pivotal role in coordinating DNA replication, cell division and cell fate decisions.
Caro
Elena
E
Centro de Biologia Molecular "Severo Ochoa", Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Gutierrez
Crisanto
C
D000818:Animals; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D002455:Cell Division; D004261:DNA Replication; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D038081:Organogenesis; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants
D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; C520031:GEM protein, Arabidopsis; D006657:Histones; D047908:Intracellular Signaling Peptides and Proteins; D010940:Plant Proteins