Transdermal resorption of an ethanol- and 2-propanol-containing skin disinfectant.
OBJECTIVE
Ethanol- or 2-propanol-containing disinfectant agents are widely used in medical practice, particularly in the surgical environment. It was the primary objective of this phase I study to comparatively investigate the transdermal resorption of ethanol and 2-propanol within 1 h after dermal application of the two agents as single preparations and a commercial product containing both alcohols in combination, respectively. The secondary objective was to examine whether a mutual influence of the two alcohols in combination exists.


METHODS
Following the double-blind, randomized, three-times cross-over design for this clinical trial, 20 ml of three different alcohol-containing disinfectants were applied on a 200-cm(2) gauze swab on skin areas, identical in size and location, of 14 healthy volunteers for 10 min to investigate the absorption rate of ethanol and 2-propanol with special focus on the question whether the two alcohols might influence each other's absorption rate when being applied in combination.


RESULTS
No clinically relevant enhancement of dermal absorption, with respect to ethanol and 2-propanol, could be observed within 1 h after application, neither when used as single preparations, nor in combination.


CONCLUSIONS
Therefore, the use of ethanol- and 2-propanol-containing disinfectants in the medical environment can be considered as safe.
Kirschner
Martin Hartwig
MH
B.Braun Melsungen AG, Stadtwaldpark 10, 34212, Melsungen, Germany.
Lang
Reinhold Andreas
RA
Breuer
Burkhard
B
Breuer
Marion
M
Gronover
Corinna Schulze
CS
Zwingers
Thomas
T
Böttrich
Johannes Georg
JG
Arndt
Andreas
A
Brauer
Ute
U
Hintzpeter
Matthias
M
Burmeister
Marc-Alexander
MA
Fauteck
Jan-Dirk
JD
D019840:2-Propanol / Q000493:pharmacokinetics*; D000096:Acetone / Q000493:pharmacokinetics; D000328:Adult; D019540:Area Under Curve; D018592:Cross-Over Studies; D004202:Disinfectants / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D004347:Drug Interactions; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012869:Skin Absorption / Q000502:physiology*; D055815:Young Adult
D004202:Disinfectants; D000096:Acetone; D000431:Ethanol; D019840:2-Propanol