Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV).
A vaccine containing inactivated polio (eIPV) (Pediacel) is now used in the UK. The effect of the eIPV on other components is not well understood. We studied Haemophilus influenzae type b (Hib) and tetanus responses in preterm infants, <32 weeks gestation at birth, immunised with the (then) standard UK primary vaccines and either oral polio vaccine (OPV) or eIPV and analysed the effect showing reduced Hib responses with eIPV.
Berrington
Janet E
JE
Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. janet.berrington@nuth.nhs.uk
Fenton
Alan C
AC
Cant
Andrew J
AJ
Spickett
Gavin P
GP
O'Keeffe
Marilyn
M
Matthews
John N S
JN
D000907:Antibodies, Bacterial / Q000097:blood*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000276:immunology; D006192:Haemophilus Infections / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage; D011134:Polysaccharides / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D006113:United Kingdom; D017778:Vaccines, Combined
D000907:Antibodies, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D011134:Polysaccharides; D013745:Tetanus Toxoid; D017778:Vaccines, Combined; C008984:polyribitol phosphate