title: GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI.
abstract: The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.
authors.affiliation: Department of Psychiatry, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. george.northoff@medizin.uni-magdeburg.de
authors.forename: Georg
authors.initials: G
authors.lastname: Northoff
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Schulte
authors.forename: Johannes
authors.initials: J
authors.lastname: Beck
authors.forename: Ulrike
authors.initials: U
authors.lastname: Dydak
authors.forename: Anke
authors.initials: A
authors.lastname: Henning
authors.forename: Heinz
authors.initials: H
authors.lastname: Boeker
authors.forename: Simone
authors.initials: S
authors.lastname: Grimm
authors.forename: Peter
authors.initials: P
authors.lastname: Boesiger
mesh_terms: D000328:Adult; D001775:Blood Circulation / Q000502:physiology; D001931:Brain Mapping; D004644:Emotions; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply* / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D012146:Rest; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D010100:Oxygen