Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.
Haenni
Marisa
M
Department of Fundamental Microbiology, Quartier UNIL-Sorge, Biophore Building, CH-1015 Lausanne, Switzerland.
Moreillon
Philippe
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010403:Penicillin Resistance / Q000235:genetics*; D010406:Penicillins / Q000494:pharmacology*; D012641:Selection, Genetic; D012692:Serial Passage; D054773:Streptococcus gordonii / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D010406:Penicillins