title: LEF-1 activates the transcription of E2F1.
abstract: LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further beta-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhou
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Gong
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Lu
authors.forename: Baiyang
authors.initials: B
authors.lastname: Sheng
authors.forename: Aijun
authors.initials: A
authors.lastname: Wang
authors.forename: Nanming
authors.initials: N
authors.lastname: Zhao
authors.forename: Xiufang
authors.initials: X
authors.lastname: Zhang
authors.forename: Yandao
authors.initials: Y
authors.lastname: Gong
mesh_terms: D000818:Animals; D019556:COS Cells; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D050687:E2F1 Transcription Factor; D051821:Lymphoid Enhancer-Binding Factor 1; D006655:Histone Deacetylases