Degeneration speed of corticospinal tract in patients with cerebral infarct.
OBJECTIVE
Diffusion tensor image tractography (DTT) could be useful for exploring the state of the corticospinal tract (CST) at the level of the subcortical white matter. The purpose of this study was to demonstrate the speed of degeneration of the CST in patients with cerebral infarct, using DTT.


METHODS
Two patients with middle cerebral artery territory infarct were recruited for this study. DTT was performed 5 times with an interval of 7 days, starting at 2 days after onset, using a 1.5-T system with a synergy-L Sensitivity Encoding head coil. The termination criteria used were fractional anisotrophy < 0.3, 0.2, 0.1, respectively, and an angle change > 45 degrees .


RESULTS
Detection of CST degeneration began at the 9 day DTT in both patients. The most rapid CST degeneration was noted for 7 days at 16 days from onset. We did not detect any tract in the affected hemisphere of both patients at the 23-day DTT.


CONCLUSIONS
We demonstrated that CST degeneration begins before 9 days from onset and progresses rapidly in patients with middle cerebral artery territory infarct. It seems that the CST degeneration began earlier than expected.
Kim
Dong Gyu
DG
Department of Physical Medicine & Rehabilitation, Yeungnam University College of Medicine, Taegu, Republic of Korea.
Ahn
Young Hwan
YH
Byun
Woo Mok
WM
Kim
Tae Gun
TG
Yang
Dong Suk
DS
Ahn
Sang Ho
SH
Cho
Yoon Woo
YW
Jang
Sung Ho
SH
D000328:Adult; D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011712:Pyramidal Tracts / Q000473:pathology*; D013997:Time Factors