Immune reconstitution inflammatory syndrome associated with progressive multifocal leukoencephalopathy in a perinatally acquired human immunodeficiency virus-infected young adult.
Perinatally infected children represent a large proportion of the youth living with human immunodeficiency virusinfection/acquired immunodeficiency syndrome (HIV/AIDS). Because of nonadherence to treatment, an increasing number of perinatally acquired HIV-infected adolescents and young adults are showing virologic failure and immune suppression. We report a case of progressive multifocal leukoencephalopathy secondary to immune reconstitution inflammatory syndrome in a perinatally HIV-infected young adult, occurred shortly after the revision of an antiretroviral regimen. The patient showed marked improvement with the combination of corticosteroid and antiretroviral treatment.
Ch'ng
Tong Wei
TW
Division of Pediatric Pulmonary, Allergy, Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA. chngto@umdnj.edu
Dieudonne
Arry
A
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000821:virology*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000635:transmission / Q000821:virology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications*; D018445:Infectious Disease Transmission, Vertical; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000821:virology*
D019380:Anti-HIV Agents