title: Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen.
abstract: We evaluated the effects of a 50% methanol extract of Citrus unshiu powder (MEC) on cytokines in peripheral blood mononuclear cells (PBMCs) obtained from patients with seasonal allergic rhinitis to cedar pollen. The levels of cytokines, such as TNF-alpha, IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-12 (p70), IL-13, and GM-CSF, produced by pollen-stimulated PBMC were measured. We found that MEC suppressed pollen-induced TNF-alpha release and increased IFN-gamma release from PBMCs. The results suggest that Citrus unshiu powder has an immunomodulatory effect in vitro and that its use could improve seasonal allergic rhinitis symptoms.
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Japan. stanabe@hiroshima-u.ac.jp
authors.forename: Soichi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kinuta
authors.forename: Hatsumi
authors.initials: H
authors.lastname: Yasumatsu
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Takayanagi
authors.forename: Shoko
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Naondo
authors.initials: N
authors.lastname: Takido
authors.forename: Masanori
authors.initials: M
authors.lastname: Sugiyama
mesh_terms: D002957:Citrus; D016207:Cytokines / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D011058:Pollen / Q000276:immunology*; D011208:Powders / Q000737:chemistry; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
chemical_list: D016207:Cytokines; D010936:Plant Extracts; D011208:Powders; D000432:Methanol