Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample.
This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.
Perera
Alexandre
A
Centre de Recerca en Enginyeria Biomedica, Dept. d'Eng. Sistemes i Automatica Industrial, Universitat Politecnica de Catalunya, Pau Gargallo, 5, 08028 Barcelona, Spain. alexandre.perera@upc.edu
Buil
Alfonso
A
Di Bernardo
Maria Chiara
MC
Sabater-Lleal
Maria
M
Pattini
Linda
L
Souto
Juan Carlos
JC
Fontcuberta
Jordi
J
Vallverdu
Montserrat
M
Soria
Jose Manuel
JM
Caminal
Pere
P
D000704:Analysis of Variance; D016000:Cluster Analysis; D005167:Factor VII / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D019851:Thrombophilia / Q000235:genetics*
D005167:Factor VII