Fatal hypertensive crisis as presentation of mitochondrial complex I deficiency.
Complex I deficiency is a frequent defect of the mitochondrial electron transport chain. We report on a 3-year-old boy, who rapidly deteriorated after sudden flushing and collapse. This fatal and unusual case was characterized by widely uncontrollable arterial hypertension. It might indicate that hypertensive crisis could be a potential manifestation of mitochondrial disorders.
Lohmeier
K
K
Department of General Pediatrics, Heinrich-Heine-Universität, Düsseldorf, Germany. lohmeier@uni-duesseldorf.de
Distelmaier
F
F
van den Heuvel
L P
LP
Rodenburg
R J T
RJ
Smeitink
J
J
Mayatepek
E
E
Hoehn
T
T
D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D002540:Cerebral Cortex / Q000473:pathology*; D002675:Child, Preschool; D042967:Electron Transport Complex I / Q000172:deficiency*; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008297:Male; D028361:Mitochondrial Diseases / Q000150:complications* / Q000201:enzymology / Q000473:pathology
D000959:Antihypertensive Agents; D042967:Electron Transport Complex I