Direct one-pot synthesis of alpha-siloxy-Weinreb amides from aldehydes.
A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.
Nemoto
Hisao
H
Department of Pharmaceutical Chemistry, Division of Health Biosciences, Graduate School of The University of Tokushima, 1-78-1, Tokushima, Japan 770-8505. nem@ph.tokushima-u.ac.jp
Ma
Rujian
R
Moriguchi
Hideki
H
Kawamura
Tomoyuki
T
Kamiya
Masaki
M
Shibuya
Masayuki
M
D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D000447:Aldehydes; D000577:Amides