title: Trends in breast-conserving surgery in Denmark, 1982-2002.
abstract: Using hospital discharge data from the counties in Northern Denmark and the Danish Cancer Registry, we examined the trend in the prevalence of breast-conserving surgery (BCS) to treat primary breast cancer from 1982 through 2002, with an emphasis on publications that may have influenced surgical practice in Denmark. Overall, the prevalence of BCS increased from less than 1% of breast cancer operations in 1982 to approximately 25% by 2002. The rise in prevalence was most pronounced for the treatment of young women and women with early-stage breast cancer. Of three pivotal clinical trials, the most significant trigger of the upward trend appeared to be a study conducted by the Danish Breast Cancer Cooperative Group, published in 1988. After 1988, there was a steep rise in the prevalence of BCS. By 2002, BCS prevalence appeared to reach a threshold at 25% of breast cancer operations, seemingly defined by the proportion of new breast cancer cases who are good candidates for BCS.
authors.affiliation: Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, TE3, Boston, MA 02118, USA. tpa@bu.edu
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Ahern
authors.forename: Heidi
authors.initials: H
authors.lastname: Larsson
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Garne
authors.forename: Deirdre P
authors.initials: DP
authors.lastname: Cronin-Fenton
authors.forename: Henrik Toft
authors.initials: HT
authors.lastname: Sørensen
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Lash
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000601:surgery*; D002986:Clinical Trials as Topic; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000706:statistics & numerical data*; D008875:Middle Aged; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data*