title: Does the biocompatibility of the peritoneal dialysis solution matter in assessment of peritoneal function?
abstract: BACKGROUND
  Peritoneal function tests are performed in peritoneal dialysis (PD) patients to characterize peritoneal membrane status. A low pH/high glucose degradation product (GDP) dialysis solution is used as the test solution. The objective of the present study was to compare a 3.86% glucose, low pH/high GDP dialysis solution (pH 5.5) with a 3.86% glucose, normal pH/low GDP dialysis solution (pH 7.4) in assessments of peritoneal membrane function.
  
  
  METHODS
  Two standard peritoneal permeability analyses (SPA) were performed in 10 stable PD patients within 2 weeks. One SPA was done with the 3.86% low pH/high GDP solution, and the other with the 3.86% normal pH/low GDP solution. The sequence of the two tests was randomized.
  
  
  RESULTS
  Fluid transport parameters and glucose absorption were not different between the two groups. No differences were found for the mass transfer area coefficients (MTACs) of low molecular weight solutes calculated over the whole dwell. However, MTAC urea in the first hour of the dwell was higher in the test done with low pH/high GDP dialysate, suggesting more peritoneal vasodilation. No difference was found in protein clearances. Sodium sieving at multiple time points during the dwell was similar with the two solutions.
  
  
  CONCLUSIONS
  The results obtained with the glucose-containing normal pH/low GDP dialysis solution were similar to those obtained with the glucose-containing low pH/high GDP dialysate in assessments of peritoneal membrane function.
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam. Alenaparikova@hotmail.com
authors.forename: Alena
authors.initials: A
authors.lastname: Parikova
authors.forename: Dirk G
authors.initials: DG
authors.lastname: Struijk
authors.forename: Machteld M
authors.initials: MM
authors.lastname: Zweers
authors.forename: Monique
authors.initials: M
authors.lastname: Langedijk
authors.forename: Natalie
authors.initials: N
authors.lastname: Schouten
authors.forename: Nicole
authors.initials: N
authors.lastname: van den Berg
authors.forename: Saskia
authors.initials: S
authors.lastname: Duis
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Krediet
mesh_terms: D000328:Adult; D001692:Biological Transport; D001826:Body Fluids / Q000378:metabolism; D002853:Chromatography, Liquid; D003404:Creatinine / Q000378:metabolism; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D011506:Proteins / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D015314:Dialysis Solutions; D011506:Proteins; D014527:Uric Acid; D014508:Urea; D012964:Sodium; D003404:Creatinine; D005947:Glucose