title: Nonlinear modeling of cerebral state index in dogs.
abstract: The Cerebral State Index (CSI) is an electroencephalogram derived signal representing the depression of central nervous activity produced by anesthetic drugs. In this study, a nonlinear model was developed to describe the CSI tendency during general anesthesia in dogs, by evaluating the effect of the anesthetic drug propofol. The model was based on a compartmental and Hill Equation structure with individually identified parameters. The clinical data of 14 dog surgeries were collected and used for modeling and testing. The model presented good results, following the CSI trend. A model for drug-effect for veterinarian anesthesia is an important step when developing advisory, educational and control systems. The overall aim is to improve animal safety and comfort.
authors.affiliation: Faculdade de Ciências da Universidade do Porto, Departamento de Matemática Aplicada, Rua do Campo Alegre 687, Porto, Portugal. susana.bras@fc.up.pt
authors.forename: Susana
authors.initials: S
authors.lastname: Brás
authors.forename: Nadja
authors.initials: N
authors.lastname: Bressan
authors.forename: Lénio
authors.initials: L
authors.lastname: Ribeiro
authors.forename: David A
authors.initials: DA
authors.lastname: Ferreira
authors.forename: Luís
authors.initials: L
authors.lastname: Antunes
authors.forename: Catarina S
authors.initials: CS
authors.lastname: Nunes
mesh_terms: D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000818:Animals; D054022:Cerebrum / Q000503:physiopathology*; D004285:Dogs; D004569:Electroencephalography; D005260:Female; D008297:Male; D008954:Models, Biological; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000008:administration & dosage
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol