Prospective study of dietary pattern and risk of Parkinson disease.
BACKGROUND
Several studies have shown associations between Parkinson Disease (PD) risk and individual foods and nutrients with inconsistent results.


OBJECTIVE
We examined associations between dietary patterns and risk of PD in the Health Professionals Follow-Up Study (1986-2002) and the Nurses' Health Study (1984-2000).


METHODS
We included 49 692 men and 81 676 women free of PD at baseline and used principal components analysis to identify major dietary patterns and the Alternate Healthy Eating Index (AHEI) and the alternate Mediterranean Diet Score (aMed) to assess diet quality. Relative risks (RRs) were computed by using Cox proportional hazards models within each cohort and were pooled by using a random-effects model.


RESULTS
We documented 508 new PD cases after 16 y of follow-up. The principal components analysis identified 2 dietary patterns: prudent and Western. The prudent dietary pattern, characterized by high intakes of fruit, vegetables, and fish, was inversely associated with PD risk, but the Western pattern was not. The pooled multivariate-adjusted RR for the top compared with the bottom quintiles of the prudent score was 0.78 (95% CI: 0.56, 1.07; P for trend = 0.04). For the AHEI, the pooled multivariate-adjusted RR for the top compared with the bottom quintile was 0.70 (95% CI: 0.51, 0.94; P for trend = 0.01) and for aMED was 0.75 (95% CI: 0.57, 1.00; P for trend = 0.07).


CONCLUSIONS
Dietary patterns with a high intake of fruit, vegetables, legumes, whole grains, nuts, fish, and poultry and a low intake of saturated fat and a moderate intake of alcohol may protect against PD. Benefits of a plant-based dietary pattern including fish to PD merit further investigation.
Gao
Xiang
X
Department of Nutrition, Harvard School of Public Health, Cambridge, MA 02115, USA. xgao@hsph.harvard.edu
Chen
Honglei
H
Fung
Teresa T
TT
Logroscino
Giancarlo
G
Schwarzschild
Michael A
MA
Hu
Frank B
FB
Ascherio
Alberto
A
D000328:Adult; D000368:Aged; D004032:Diet; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors
D006710:Homocysteine