title: [Local therapy of grade IIa burns: efficacy and tolerability of a new hydrosome wound gel for the local treatment of grade IIa burns as compared with silver sulfadiazine ointment].
abstract: BACKGROUND
  A new hydrosome wound gel is based on a new mechanism of action. It contains hydrosomes that penetrate to the wound bed and supply the wound with phospholipids, which are identical to membrane phospholipids of human cells. In this manner it supports the proliferative processes during wound healing.
  
  
  METHODS
  In a randomized, controlled, intraindividual comparative study of 47 patients with grade IIa burns, the hydrosome wound gel was tested against silver sulfadiazine cream. Digital pictures of the burn wounds were taken daily, and the wounds were analyzed in terms of their reepithelization rate.
  
  
  RESULTS
  Wounds receiving the hydrosome wound gel healed 1.5-2 days faster than wounds treated with sulfadiazine cream (9.9+/-4.5 days vs. 11.3+/-4.9 days, p=0.015). In 66% of the patients, faster epithelization was observed with the hydrosome wound gel treatment. The hydrosome gel guaranteed secure prophylaxis against infection, and it was well tolerated and easy to apply.
  
  
  CONCLUSIONS
  In this study, the treatment of grade IIa burn wounds with hydrosome wound gel led to faster wound closure compared with treatment with sulfadiazine cream. Therefore, hydrosome gel represents a good alternative to sulfadiazine cream.
authors.affiliation: Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Klinikum der Ruhr-Universität Bochum, Bochum, Germany. joerg.hauser@ruhr-uni-bochum.de
authors.forename: J
authors.initials: J
authors.lastname: Hauser
authors.forename: O
authors.initials: O
authors.lastname: Rossbach
authors.forename: S
authors.initials: S
authors.lastname: Langer
authors.forename: P
authors.initials: P
authors.lastname: Vogt
authors.forename: G
authors.initials: G
authors.lastname: Germann
authors.forename: H U
authors.initials: HU
authors.lastname: Steinau
authors.forename: K
authors.initials: K
authors.lastname: Reimer
authors.forename: M
authors.initials: M
authors.lastname: Hopp
authors.forename: B
authors.initials: B
authors.lastname: Langer-Brauburger
authors.forename: B
authors.initials: B
authors.lastname: Bosse
authors.forename: H H
authors.initials: HH
authors.lastname: Homann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002056:Burns / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D008081:Liposomes; D008875:Middle Aged; D011205:Povidone / Q000008:administration & dosage*; D011206:Povidone-Iodine / Q000008:administration & dosage*; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D008081:Liposomes; C525696:Repithel; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011206:Povidone-Iodine; D011205:Povidone; D012837:Silver Sulfadiazine