Smallpox vaccination and ischemic coronary events in healthy adults.
Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.
Eckart
Robert E
RE
Brooke Army Medical Center, Fort Sam Houston, TX, United States. robert.eckart@amedd.army.mil
Shry
Eric A
EA
Atwood
J Edwin
JE
Brundage
John F
JF
Lay
Jenny C
JC
Bateson
Thomas F
TF
Grabenstein
John D
JD
D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D005260:Female; D006801:Humans; D017589:Immunization Programs; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012900:Smallpox Vaccine / Q000009:adverse effects*; D014481:United States; D014611:Vaccination / Q000009:adverse effects*
D012900:Smallpox Vaccine