Pharmacological fMRI--challenges in analysing drug-induced single-event BOLD responses.
The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.
Pohlmann
Andreas
A
Neurology & GI Centre of Excellence in Drug Discovery, GlaxoSmithKline R&D Ltd., Harlow, CM19 5AW, UK. andreas.x.pohlmann@gsk.com
Barjat
Hervé
H
Tilling
Lorna C
LC
James
Michael F
MF
D000465:Algorithms; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D004364:Pharmaceutical Preparations; D010100:Oxygen