Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.
Gastric cancer (GC) is a common and complex disease caused by multifactors. The aim of our study was to investigate the association of the common polymorphisms detected in insulin-like growth factor (IGF)-II, IGF-1 receptor, insulin-like growth factor binding protein 1 (IGFBP1), insulin (INS) and tyrosine hydroxylase (TH) with susceptibility to GC in a northwestern Chinese population. One hundred and fifty-four GC patients and 166 healthy controls were investigated in our study. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The frequencies of CC and CT genotypes of TH were significantly higher in GC patients than in controls, as the odds ratios were 3.03 (95%CI 1.438-6.362, P=0.003) and 1.97 (95%CI 1.218-3.167, P=0.005), respectively. No association was found between the polymorphisms of IGF-II ApaI, insulin-like growth factor-1 receptor MnlI, IGFBP1 Bgl II and INS-23HphI and the development of GC. The presence of CC and CT genotypes of TH was associated with a significantly increased risk of GC. But the polymorphisms of other genes detected did not indicate an increased risk of GC in the investigated population.
Li
Z Q
ZQ
School of Life Science, Lanzhou University, Lanzhou City, Gansu Province, China 730000.
Yu
W P
WP
Xie
X D
XD
Li
P Q
PQ
Guo
T K
TK
Zhang
W H
WH
An
L Z
LZ
Wang
X L
XL
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000235:genetics; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D017451:Receptors, Somatomedin / Q000235:genetics; D013274:Stomach Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
C032231:IGFBP1 protein, human; D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D017451:Receptors, Somatomedin; D007335:Insulin-Like Growth Factor II; D014446:Tyrosine 3-Monooxygenase