Meta-analysis of aggression and/or hostility-related events in children and adolescents treated with fluoxetine compared with placebo.
This meta-analysis assessed aggression and/or hostility-related events in children and adolescents treated with fluoxetine (n = 376) compared with placebo (n = 255). Aggression and/or hostility-related events were identified in 2.1% of fluoxetine versus 3.1% of placebo-treated patients (p = 0.588). This analysis fails to support an association between fluoxetine treatment and increased risk of aggression and/or hostility-related events in children and adolescents compared with placebo.
Tauscher-Wisniewski
Sitra
S
Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA.
Nilsson
Mary
M
Caldwell
Cathy
C
Plewes
John
J
Allen
Albert J
AJ
D000293:Adolescent; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006791:Hostility; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D012306:Risk
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine