title: Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro.
abstract: Bone marrow stromal cells (MSCs) have the capability of differentiating into mesenchymal and non-mesenchymal lineages. In this study, MSCs isolated from adult Sprague-Dawley rats were cultured to proliferation, followed by in vitro induction under specific conditions. The results demonstrated that MSCs were transdifferentiated into cells with the Schwann cell (SC) phenotypes according to their morphology and immunoreactivities to SC surface markers including S-100, glial fibrillary acidic protein (GFAP) and low-affinity nerve growth factor receptor (p75). Consequently, rat adult MSCs can be induced in vitro to differentiate into SC-like cells, thus developing an abundant and accessible SC reservoir to meet the requirements of constructing tissue engineered nerve grafts for peripheral nerve repair.
authors.affiliation: The Jiangsu Province Key Lab of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, China.
authors.forename: WeiWei
authors.initials: W
authors.lastname: Lin
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.forename: XiaoDong
authors.initials: X
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: XiaoSong
authors.initials: X
authors.lastname: Gu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000166:cytology / Q000502:physiology
chemical_list: D015415:Biomarkers