title: A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii.
abstract: A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC(50): 194 muM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC(50): 16.9 microM) and superoxide anion scavenging activity (IC(50): 28.5 microM).
authors.affiliation: Interdisciplinary Graduate School of Science and Technology, Shinshu University, Nagano 399-4598, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Morimura
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamazaki
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Hattori
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Makabe
authors.forename: Tsunashi
authors.initials: T
authors.lastname: Kamo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hirota
mesh_terms: D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D025282:Mycelium / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D020072:Polyporales / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010455:Peptides; D010851:Picrates; C526356:daedalin A; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl; D014442:Monophenol Monooxygenase