[Cystoid macular edema after cataract operation--a etiopathogenesis and role of prostaglandins].
Cystoid macular oedema (CME), a late complication after the cataract operation, or Irvine's-Gass's syndrome, may compromises the good postoperative results of visual acuity in certain patients. Literature data reveal to a series of conditions and factors that predispose or provoke its appearance, such as anterior segment and other complications of the cataract extraction, role of some medicaments used in cataract surgery, light toxicity of the macular region during the operation, systemic vascular diseases or intraocular inflammatory disease. Current data point at the effect of prostaglandins on the eye, and on disturbances during their removal. During cataract extraction, surgical trauma stimulates the uveal tissue to sinthetise some of prostaglandins and contributes to dysfunction of the active transport which is responsible for their elimination from the eye. Synthesis and accumulation of prostaglandin E2(PGE2), in connection with this operation, are confirmed experimentally. PGE2 extends through eye mediums to the posterior pole of the globe, where the heamatoocular barrier at the level of its cells is interrupted, resulting in a typical picture due to the accumulation of exudate in certain layers of the macular region. References about treatment of cystoid macular oedema by prostaglandin synthesis inhibitors also may suggest a good role of this drug in the treatment of this ocular complication.
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D002387:Cataract Extraction / Q000009:adverse effects*; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans; D008269:Macular Edema / Q000209:etiology* / Q000503:physiopathology
D015232:Dinoprostone