Li-cadherin is inversely correlated with galectin-3 expression in gastric cancer.
The aims of this study were to examine the expressions of Li-cadherin and Galectin-3 in gastric cancer, and the correlation between Li-cadherin and Galectin-3 in gastric cancer was also analyzed. The present study investigated the expression level of Li-cadherin and Galectin-3 by immunohistochemistry and semiquantitative polymerase chain reaction (PCR), and correlated this with clinicopathologic parameters in 91 cases of gastric cancer. The correlation between expression levels of Li-cadherin and Galectin-3 was analyzed by Spearman correlation analysis. The expression level of Li-cadherin mRNA was correlated to differentiation and lymph node metastasis, and the expression level of Galectin-3 was related to TNM staging, differentiation and lymph node metastasis. On Spearman correlation analysis, a definitive negative correlation was found between the expression levels of Li-cadherin and Galectin-3 in gastric cancerous tissues. We postulate that interaction between Li-cadherin and Galectin-3 may play an important role in the development of gastric cancer.
Dong
Wei-Guo
WG
Department of Gastroenterology, Renmin Hospital of Wuhan University, JieFang Road 238, WuHan 430060, PR China. dongwg66@yahoo.com.cn
Yu
Qiong-Fang
QF
Xu
Yu
Y
Fan
Li-Fang
LF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015820:Cadherins / Q000378:metabolism*; D002454:Cell Differentiation; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism*
C490584:CDH17 protein, human; D015820:Cadherins; D037502:Galectin 3