[Apolipoprotein A in patients with alcoholic liver disease].
The aim of the present study was to determine the apolipoprotein A (APO-A) an the high density lipoprotein (HDL) plasma concentrations in 25 patients with alcoholic liver cirrhosis. To evaluate the severity of liver disease serum albumin, bilirubin and total bile acids were measured. The serum level of APO-A and HDL was significantly lower in patients with alcoholic liver cirrhosis than in normal controls (p < 0.01) and markedly lower in patients with advanced liver cirrhosis. Apolipoprotein A concentrations in plasma correlated positively with serum albumin (p < 0.01) and negatively with serum bilirubin (p < 0.01) and bile acids (p < 0.01). Thus, he apoliprotein A level seems to reflect the severity of liver disease.
Kostić
N
N
Bozanić
M
M
Cvetković
R
R
Lalević
S
S
D000328:Adult; D001054:Apolipoproteins A / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001054:Apolipoproteins A; D008075:Lipoproteins, HDL