title: [Modern attitude towards management of laryngopharyngeal form of gastroesophageal reflux disease. Lithuanian clinical practice guidelines for adults].
abstract: The aim of this article is to introduce Lithuanian clinical practice guidelines for the management of laryngopharyngeal form of gastroesophageal reflux disease for standardization of the diagnosis and treatment of the disease and prevention of its complications. Composed guidelines provide recommendations for primary care physicians as well as otorhinolaryngologists and gastroenterologists for the management of adults with uncomplicated laryngopharyngeal form of gastroesophageal reflux disease. Committee composed of experts from Lithuanian Otorhinolaryngological and Gastroenterological Societies developed guidelines based on a comprehensive review of the evidence-based literature related to laryngopharyngeal form of gastroesophageal reflux disease and guidelines of other countries. The guidelines provide description of each medicine groups with emphasis on proton pump inhibitors as the most effective drugs for the treatment of laryngopharyngeal form of gastroesophageal reflux disease. Indications for empirical treatment with proton pump inhibitors are described, as well as duration of treatment, doses, optimal regimen of use, and assessment of treatment efficacy. The therapy should begin with the application of proton pump inhibitors twice daily, before meal for three months. Combined therapy for nonresponders is described. Algorithm for stopping the medication is recommended. These recommendations may provide an efficient and economical approach to the management of this problem.
authors.affiliation: Department of Otorhinolaryngology, Kaunas University of Medicine, Kaunas, Lithuania. norai_s@yahoo.com
authors.forename: Nora
authors.initials: N
authors.lastname: Siupsinskiene
authors.forename: Virgilijus
authors.initials: V
authors.lastname: Uloza
authors.forename: Rūta
authors.initials: R
authors.lastname: Pribuisiene
authors.forename: Evaldas
authors.initials: E
authors.lastname: Butkus
authors.forename: Limas
authors.initials: L
authors.lastname: Kupcinskas
mesh_terms: D000328:Adult; D000465:Algorithms; D000863:Antacids / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004294:Domperidone / Q000008:administration & dosage / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007827:Laryngitis / Q000175:diagnosis / Q000209:etiology; D007828:Laryngoscopy; D007830:Larynx / Q000503:physiopathology*; D008097:Lithuania; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D010612:Pharyngitis / Q000209:etiology; D010614:Pharynx / Q000503:physiopathology*; D017410:Practice Guidelines as Topic; D011320:Primary Health Care; D054328:Proton Pump Inhibitors; D012008:Recurrence; D013997:Time Factors
chemical_list: D000863:Antacids; D000897:Anti-Ulcer Agents; D018492:Dopamine Antagonists; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D004294:Domperidone; D009853:Omeprazole