title: Immunological response induced by alternated cooling and heating of breast tumor.
abstract: A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.
authors.affiliation: Department of Biomedical Engineering, School of Life Science and Technology, Shanghai Jiao Tong University, PR China.
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Dong
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Lisa X
authors.initials: LX
authors.lastname: Xu
mesh_terms: D000818:Animals; D003080:Cold Temperature; D005260:Female; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods*; D007036:Hypothermia, Induced / Q000379:methods*; D007113:Immunity, Innate / Q000276:immunology* / Q000528:radiation effects*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C