Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production.
In this paper, radionuclidic impurities generated during the bombardment of [18 O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) were studied. In order to assess such impurities and the efficacy of purification methods through the different steps of the synthesis, samples of the target filters, purification columns, [18 O]water recovered after the synthesis, and the final solution was collected and their activities measured and analyzed by means of a gamma-ray spectrometry system. The data demonstrated that purification methods adopted for the synthesis provide the [18F]FDG radionuclidically pure, as requested by the EU Pharmacopeia.
Marengo
Mario
M
Medical Physics Department, S. Orsola-Malpighi Hospital, Bologna, Italy. marengo@med.unibo.it
Lodi
Filippo
F
Magi
Silvia
S
Cicoria
Gianfranco
G
Pancaldi
Davide
D
Boschi
Stefano
S
D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis* / Q000302:isolation & purification; D010100:Oxygen / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification; D013051:Spectrometry, Gamma
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D010100:Oxygen