Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin.
Dietary effects of medium-chain triacylglycerols (MCT) and fucoxanthin (Fc) on abdominal fat weight were determined using KK-Ay obese mouse. Experimental diet contained MCT(0.9%), Fc (0.1%), or MCT (0.9%) +Fc (0.1%). The abdominal fat weight of mice fed with Fc was significantly lower than that of mice fed with MCT. Uncoupling protein 1 (UCP1), a key molecule for metabolic thermogenesis, was clearly expressed in the white adipose tissue (WAT) of mice fed Fc, but little expression in that of the mice fed MCT. The anti-obesity effect of Fc was increased by mixing Fc with MCT. This increase would be due to the increase in the absorption rate of Fc by MCT.
Maeda
Hayato
H
Faculty of Fisheries Sciences, Hokkaido University, Hokkaido, Japan. hayatosp@fish.hokudai.ac.jp
Hosokawa
Masashi
M
Sashima
Tokutake
T
Funayama
Katsura
K
Miyashita
Kazuo
K
D050153:Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D020738:Leptin / Q000097:blood; D051379:Mice; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry; D024341:Xanthophylls / Q000008:administration & dosage* / Q000737:chemistry
D004041:Dietary Fats; D020738:Leptin; D014280:Triglycerides; D024341:Xanthophylls; C025164:fucoxanthin