Porphyria cutanea tarda as rare cutaneous manifestation of hepatic metastases treated with interferon.
A 53-year-old woman with blistering on the hands was diagnosed with porphyria cutanea tarda (PCT). At that time, she was treated with interferon for liver metastasis of a pancreas tumor since 7 years. Although apparently rare, PCT has been described as possible cutaneous manifestation both of hepatic tumors and interferon treatment. Further, PCT can also be exacerbated by hepatitis C virus infection, alcohol, estrogens, HFE gene mutations predisposing for hereditary hemochromatosis, hexachlorobenzene, and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Therefore, it is important to keep in mind that the manifestation of PCT may be associated with distinct precipitating factors, which are briefly discussed here.
Mosterd
Klara
K
Department of Dermatology and Euregional Porphyria Center Maastricht-Aachen (EPCMA), University Hospital Maastricht, Maastricht, The Netherlands. kmo@sder.azm.nl
Henquet
Charles
C
Frank
Jorge
J
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000175:diagnosis / Q000209:etiology*; D011994:Recombinant Proteins
D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins