title: [Latest advances of SLA class I genes].
abstract: The Swine leukocyte antigen (SLA) class I genes encode multi-glycoproteins on cell surface, which present endogenous antigenic peptides to T cells and thus initiate specific immune responses. In this article, latest advances on molecular structure, expression in tissues, regulation of expression, genotyping, polymorphism, and evolution of SLA class I genes were introduced, in which genotyping and polymorphism were emphasized. Molecular typing methods of SLA class I genes include serological method, DNA sequencing, PCR-SSP, PCR-SSOP and MS, of which PCR-SSP is frequently used in genotyping of SLA class I genes as a simple and rapid method. Future directions for the study and application of SLA class I genes on gene functions, peptide vaccine, xenotransplantation were also discussed.
authors.affiliation: Department of Animal Science, Foshan University, Nanhai 528231, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Tao
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Qi-Zhen
authors.initials: QZ
authors.lastname: Zuo
mesh_terms: D000818:Animals; D001483:Base Sequence; D019143:Evolution, Molecular; D005260:Female; D015870:Gene Expression / Q000235:genetics; D005805:Genes, MHC Class I / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; C438668:swine leukocyte antigen