Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer.
Müller
Jens
J
Institute of Experimental Haematology and Transfusion Medicine, Universität Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Wulffen
Bernhard
B
Pötzsch
Bernd
B
Mayer
Günter
G
D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D001483:Base Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism*
D052157:Aptamers, Nucleotide; D004791:Enzyme Inhibitors; D008024:Ligands; D013917:Thrombin