title: Anxiogenic potential of ciprofloxacin and norfloxacin in rats.
abstract: BACKGROUND
  The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.
  
  
  METHODS
  The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.
  
  
  RESULTS
  The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.
  
  
  CONCLUSIONS
  The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin.
authors.affiliation: Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: A K
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: S
authors.initials: S
authors.lastname: Yanpallewar
authors.forename: S B
authors.initials: SB
authors.lastname: Acharya
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001007:Anxiety / Q000139:chemically induced* / Q000523:psychology; D002939:Ciprofloxacin / Q000633:toxicity*; D005106:Exploratory Behavior / Q000187:drug effects; D005239:Fear / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009643:Norfloxacin / Q000633:toxicity*; D051381:Rats; D012919:Social Behavior; D012931:Social Environment
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D009643:Norfloxacin