title: Prediction of community outcome in schizophrenia 1 year after discharge from inpatient treatment.
abstract: This longitudinal study aimed at identifying predictors of community outcome from a broad range of neuropsychological, clinical psychopathologic, sociodemographic, and treatment related factors. N = 96 schizophrenia patients were assessed both at baseline during inpatient treatment and 1 year after discharge from hospital (follow-up). At follow-up functional outcome was measured by the Global Assessment of Functioning Scale (GAF) and the Social Adjustment Scale II (SAS II). Data were analyzed in an explorative way by means of multiple linear regression analyses. Three out of the five functional outcome measures were predicted by the negative syndrome and measures of cognitive functioning. However, the positive syndrome also consistently predicted psychosocial functioning. Altogether, the regression models explained between 20% and 35% of the variance in our outcome measures. The findings not only reemphasize that negative symptoms and cognitive dysfunctions are key determinants of community outcome but also point to a potential predictive relevance of positive symptoms.
authors.affiliation: Dept. of Psychiatry and Psychotherapy, University of Tuebingen, Osiander Str. 24, 72076, Tuebingen, Germany. andreas.wittorf@med.uni-tuebingen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Wittorf
authors.forename: Georg
authors.initials: G
authors.lastname: Wiedemann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Buchkremer
authors.forename: Stefan
authors.initials: S
authors.lastname: Klingberg
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000223:Adaptation, Psychological; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003627:Data Interpretation, Statistical; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006760:Hospitalization; D006801:Humans; D007297:Inpatients; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D010351:Patient Discharge; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology; D055502:Secondary Prevention; D012919:Social Behavior; D012959:Socioeconomic Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents