title: FDTD study of the focusing properties of a hybrid hyperthermia and radiometry imaging system using a realistic human head model.
abstract: Aim of this study is twofold; on one hand, the investigation of the focusing attributes of a microwave radiometry tomography system with the use of a realistic human head model and on the other hand, the system's ability to perform a hyperthermia treatment. The operation principle of the device is based on an ellipsoidal conductive wall cavity, which provides the required beamforming and focusing. The biological tissue under treatment and/or measurement is placed on one of the two focal points whereas on the other one, a radiating or receiving antenna, which measures the black body type radiation emitted from the head's tissue, is placed. In previous studies simple spherical head models were used, comprising one or two layers for simulating the head tissues, along with a commercial FEM tool. In this work, a realistic adult head model developed from MRI scans of a human head is used. The realistic model with detailed structural and electromagnetic tissue characteristics enables more in depth theoretical investigation of the system capabilities. Extensive simulations using a commercial FDTD tool are performed in a wide range of operating frequencies. In order to explore the feasibility of heating and monitoring specific brain areas, the capability of focusing the electric field in specific areas inside the human head is investigated and further discussed. The results show that simple spherical head models, used in previous studies, provide similar results with the realistic one used herein for the given geometry; that is, the electric field focuses on the head's center, assuming the head as a homogeneous sphere. However, the deposition of the electromagnetic energy on the head tissues depends on the operating frequency and position of the head in the given geometry, so in therefore calculated, revealing the ability of the system to operate as a hyperthermia clinical tool, not as a stand alone device but in conjunction with other already validated devices/methods.
authors.affiliation: Institute of Communications and Computer Systems, National Technical University of Athens, 15780 Zografos, Greece.
authors.forename: Ioannis A
authors.initials: IA
authors.lastname: Gouzouasis
authors.forename: Irene S
authors.initials: IS
authors.lastname: Karanasiou
authors.forename: Nikolaos K
authors.initials: NK
authors.lastname: Uzunoglu
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006257:Head / Q000503:physiopathology*; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008872:Microwaves / Q000627:therapeutic use; D008954:Models, Biological; D011874:Radiometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity