Thalamic hyperperfusion in verbal hallucination of Parkinsonian patients.
OBJECTIVE
We compared brain perfusion image using 3D-SSP analysis of (123)I-IMP SPECT between Parkinson's disease patients with auditory verbal hallucination and those without auditory hallucination.


METHODS
Eighty-three cases with Parkinson's disease were studied. In 6 of these patients, auditory hallucination was noted. Among them, four cases had verbal hallucination and two other cases had elementary hallucination. Auditory hallucination was not found in the other 77 cases.


RESULTS
Right thalamic perfusion was significantly increased in the verbal hallucination group compared to the group that lacked auditory hallucination.


CONCLUSIONS
In Parkinson's disease, the right thalamic hyperactive state may be related to verbal hallucination.
Matsui
Hideaki
H
Department of Neurology, Sumitomo Hospital, Osaka, Japan. hide0729@kuhp.kyoto-u.ac.jp
Nishinaka
Kazuto
K
Miyoshi
Takafumi
T
Hara
Narihiro
N
Oda
Masaya
M
Kubori
Tamotsu
T
Udaka
Fukashi
F
D000368:Aged; D002560:Cerebrovascular Circulation; D005260:Female; D006212:Hallucinations / Q000145:classification / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow; D013787:Thalamic Nuclei / Q000098:blood supply* / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon