Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial.
As part of the first randomized, sham-stimulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.
Mueller
Joerg
J
Skogseid
Inger M
IM
Benecke
Reiner
R
Kupsch
Andreas
A
Trottenberg
Thomas
T
Poewe
Werner
W
Schneider
Gerd H
GH
Eisner
Wilhelm
W
Wolters
Alexander
A
Müller
J U
JU
Deuschl
Günther
G
Pinsker
Marcus O
MO
Roeste
Geir K
GK
Vollmer-Haase
Juliane
J
Brentrup
Angela
A
Krause
Martin
M
Tronnier
Volker
V
Schnitzler
Alfons
A
Voges
Jüergen
J
Nikkhah
Guido
G
Vesper
Jan
J
Naumann
Markus
M
Volkmann
Jens
J
D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D004185:Disability Evaluation; D004311:Double-Blind Method; D004421:Dystonia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010919:Placebos; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D010919:Placebos