title: Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.
abstract: Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin-lithium exchange) and is resolved in the presence of a chiral ligand.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF. i.coldham@sheffield.ac.uk
authors.forename: Iain
authors.initials: I
authors.lastname: Coldham
authors.forename: Jignesh J
authors.initials: JJ
authors.lastname: Patel
authors.forename: Sophie
authors.initials: S
authors.lastname: Raimbault
authors.forename: David T E
authors.initials: DT
authors.lastname: Whittaker
mesh_terms: D007700:Kinetics; D008094:Lithium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000302:isolation & purification; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: C454939:N-(tert-butoxycarbonyl)piperidine; D009942:Organometallic Compounds; D010880:Piperidines; D008094:Lithium