title: Evaluation of a novel immunomodulator composed of human chorionic gonadotropin and bacillus Calmette-Guerin for treatment of canine mast cell tumors in clinically affected dogs.
abstract: OBJECTIVE
  To evaluate safety and efficacy of LDI-100, a preparation containing human chorionic gonadotropin (hCG) and bacillus Calmette-Guerin (BCG), in the treatment of dogs with mast cell tumors and to compare results with those from a control group receiving single-agent vinblastine.
  
  
  METHODS
  95 dogs with measurable grade II or III mast cell tumors.
  
  
  METHODS
  Dogs were randomized to receive either LDI-100 (1.35 ng of BCG and 2 units of hCG, SC, q 24 h) or vinblastine (2 mg/m(2), IV, q 1 wk) for 6 weeks. Tumors were measured at baseline and day 42, and dogs were monitored for signs of toxicosis. Clinical performance scores were recorded at each visit. Differences in host factors (sex, weight, and age), clinical performance score, tumor response, and adverse events were analyzed.
  
  
  RESULTS
  46 dogs received LDI-100, and 49 dogs received vinblastine. No significant differences were found between the 2 treatment groups with regard to host factors or clinical performance score. Tumor response (>or=50% reduction) rates were similar between the LDI-100 and vinblastine group (28.6% and 11.7%, respectively). Dogs in the LDI-100 group had significantly less neutropenia than the vinblastine group.
  
  
  CONCLUSIONS
  hCG and BCG have immunomodulatory and antitumor effects against a variety of malignancies in humans and dogs. In this study, LDI-100 provided clinical responses comparable to single-agent vinblastine chemotherapy but without myelosuppression. LDI-100 is a promising new agent that should be further investigated for multimodality therapy of mast cell tumors in dogs.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211, USA.
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Henry
authors.forename: Sue
authors.initials: S
authors.lastname: Downing
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rosenthal
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Klein
authors.forename: Karri
authors.initials: K
authors.lastname: Meleo
authors.forename: J Armando
authors.initials: JA
authors.lastname: Villamil
authors.forename: Linda S
authors.initials: LS
authors.lastname: Fineman
authors.forename: Dudley L
authors.initials: DL
authors.lastname: McCaw
authors.forename: Mary Lynn
authors.initials: ML
authors.lastname: Higginbotham
authors.forename: John
authors.initials: J
authors.lastname: McMichael
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000627:therapeutic use*; D006063:Chorionic Gonadotropin / Q000276:immunology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000276:immunology / Q000628:therapy*; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D034801:Mastocytoma / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D011446:Prospective Studies; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D001500:BCG Vaccine; D006063:Chorionic Gonadotropin; D014747:Vinblastine