title: An efficient conversion of the carboxylic group of N-Fmoc alpha-amino acids/peptide acids into N-formamides employing isocyanates as key intermediates.
abstract: Reaction of 96% formic acid with isocyanates derived from N-Fmoc alpha-amino acids/peptide acids catalyzed by DMAP has yielded a new class of stable formamides as crystalline solids which have been characterized by IR, 1H NMR, 13C NMR, and mass spectroscopy. Conversion of the side chain carboxylic acid of N-Fmoc-5-oxazolidinones of Asp/Glu into the N-formyl group also has been accomplished. The reaction is simple, mild, and high yielding.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore 560001, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Sudarshan
authors.forename: N
authors.initials: N
authors.lastname: Narendra
authors.forename: H P
authors.initials: HP
authors.lastname: Hemantha
authors.forename: Vommina V
authors.initials: VV
authors.lastname: Sureshbabu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005559:Formamides / Q000138:chemical synthesis* / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D005559:Formamides; D017953:Isocyanates; D010455:Peptides