Accounting for pharmacokinetic and pharmacodynamic variability: ten factors to consider before prescribing.
Outcomes of pharmacological therapy are more than an accurate assessment and appropriate choice of an agent. Patient outcomes are the result of complex interactions of factors known and unknown. This study explores 10 of many factors that clinical nurse specialists should consider before writing the prescription and monitoring responses to therapy.
O'Malley
Patricia
P
Center for Nursing Excellence, Miami Valley Hospital, Dayton, Ohio 45409, USA. pomalley@mvh.org
D000367:Age Factors; D001823:Body Composition; D002626:Chemistry, Pharmaceutical; D004347:Drug Interactions; D016903:Drug Monitoring / Q000451:nursing; D011307:Drug Prescriptions / Q000451:nursing*; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000502:physiology; D009720:Nurse Clinicians / Q000458:organization & administration*; D024802:Nurse's Role; D018579:Patient Selection; D010599:Pharmacokinetics; D010600:Pharmacology; D017009:Professional Autonomy; D012727:Sex Characteristics