title: Prolonged cerebellar ataxia: an unusual complication of hypoglycemia.
abstract: A 51-year-old male with a history of insulin-dependent diabetes and polysubstance abuse presented after overdose on insulin. Soon after resuscitation, he displayed a severe ataxia in all 4 limbs and was unable to walk; all of which persisted for at least 5 days. Laboratory testing was unrevealing, including relatively normal brain magnetic resonance imaging. He had recovered full neurologic function 3 months after the event. This report describes a case of reversible cerebellar ataxia as a rare complication of severe hypoglycemia that may occur in patients with abnormal cerebellar glucose metabolism. Thus, this phenomenon should be included in the differential diagnosis of patients with a history of hypoglycemia who present with ataxia. In this context, the differential diagnosis of cerebellar ataxia is discussed, as is the proposed mechanism for hypoglycemia-induced cerebellar dysfunction.
authors.affiliation: Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA. Jonathan.Berz@bmc.org
authors.forename: Jonathan P B
authors.initials: JP
authors.lastname: Berz
authors.forename: Jay D
authors.initials: JD
authors.lastname: Orlander
mesh_terms: D002524:Cerebellar Ataxia / Q000209:etiology* / Q000473:pathology; D003920:Diabetes Mellitus / Q000188:drug therapy*; D062787:Drug Overdose; D006801:Humans; D007003:Hypoglycemia / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019966:Substance-Related Disorders