title: Tiletamine-zolazepam and xylazine is a potent cardiodepressive combination: a case report.
abstract: Intramuscular injection of tiletamine-zolazepam and xylazine is commonly used as a preanesthetic for veterinary surgical procedures and for short-term restraint. However, this combination can have marked cardiodepressive and hypothermic effects that persist for hours to days. Here we present a case report of these effects in a swine heart failure model.
authors.affiliation: MicroSystems Engineering, Lake Oswego, OR, USA. sharon.lefkov@biotronik.com
authors.forename: Sharon H
authors.initials: SH
authors.lastname: Lefkov
authors.forename: Dirk
authors.initials: D
authors.lastname: Müssig
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001831:Body Temperature / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D007035:Hypothermia / Q000139:chemically induced / Q000662:veterinary; D013522:Surgery, Veterinary / Q000379:methods; D034421:Sus scrofa; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000175:diagnosis; D013992:Tiletamine / Q000009:adverse effects*; D014991:Xylazine / Q000009:adverse effects*; D015041:Zolazepam / Q000009:adverse effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D004338:Drug Combinations; D014991:Xylazine; D013992:Tiletamine; D015041:Zolazepam