What is the role of autophagy in HIV-1 infection?
HIV-1 infection is characterized by a progressive CD4 T cell depletion. It is now accepted that apoptosis of uninfected bystander CD4 T lymphocytes plays a major role in AIDS development. Viral envelope glycoproteins (Env) are mainly involved in inducing this cell death process, but the mechanisms triggered by HIV-1 leading to immunodeficiency are still poorly understood. Recently, we have demonstrated that autophagy is a prerequisite for Env-mediated apoptosis in uninfected CD4 T cells, underlining its role in HIV-1 infection. However, occurrence of autophagy in HIV-1-infected cells has not yet been described. Several hypotheses are discussed, based on the comparison with data from other viral infections.
Espert
Lucile
L
CPBS, UM1 UM2 CNRS, Institut de Biologie, Montpellier, France.
Codogno
Patrice
P
Biard-Piechaczyk
Martine
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D054299:env Gene Products, Human Immunodeficiency Virus / Q000502:physiology
D054299:env Gene Products, Human Immunodeficiency Virus