title: A platform for in silico modeling of physiological systems.
abstract: This paper describes our challenge of developing base systems necessary and useful for a physiome typed platform for physiological modeling and simulation across multiple scales of time and size through diverse hierarchies of living organisms. Our base systems include a CellML compatible standardized description of structure and dynamic equations (rules for time evolution) of biological organisms in general. A database that can deal with the standardized description and APIs for large scale model constructions and their simulations are also considered.
authors.affiliation: Graduate School of Engineering Science, center for advanced medical engineering and informatics, Osaka University, Toyonaka, Osaka, 560-8531 Japan. kawazu@bpe.es.osaka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawazu
authors.forename: Masao
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Odai
authors.forename: Taishin
authors.initials: T
authors.lastname: Nomura
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D008954:Models, Biological; D010827:Physiology / Q000379:methods*; D012984:Software; D012985:Software Design; D014584:User-Computer Interface