Adult and fetal wound healing.
Mammalian wound healing is an intricate process involving the coordinated interaction of a variety of tissue types and cellular lineages. This is governed by a complex array of physical, biological and chemical signals. In adult tissue, the successful completion of wound healing inevitably results in the formation of scar. However, animal studies of embryonic tissue have shown that early gestation fetal wounds heal with complete restoration of tissue structure and function. The exact mechanisms underlying scarless healing in the fetus remain to be elucidated.
Hantash
Basil M
BM
The Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA.
Zhao
Longmei
L
Knowles
Joseph A
JA
Lorenz
H Peter
HP
D000818:Animals; D049109:Cell Proliferation; D002921:Cicatrix; D016207:Cytokines / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction; D012867:Skin / Q000196:embryology* / Q000378:metabolism*; D014945:Wound Healing
D016207:Cytokines