Imaging the neurochemistry of alcohol and substance abuse.
Animal models of abuse and dependence have long suggested that chronic drug and alcohol exposure is associated with marked changes in neurochemistry. The development of PET and SPECT imaging now allows investigation of the effects of addiction on the neurochemistry of the human brain. This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence.
Martinez
Diana
D
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box #31, New York, NY 10032, USA. dm437@columbia.edu
Kim
Jong-Hoon
JH
Krystal
John
J
Abi-Dargham
Anissa
A
D000437:Alcoholism / Q000000981:diagnostic imaging*; D006801:Humans; D049268:Positron-Emission Tomography; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon