Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects.
Hinerfeld
Douglas A
DA
Moonis
Majaz
M
Swearer
Joan M
JM
Baker
Stephen P
SP
Caselli
Richard J
RJ
Rogaeva
Ekaterina
E
St George-Hyslop
Peter
P
Pollen
Daniel A
DA
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D053327:Apolipoprotein E4 / Q000235:genetics; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010446:Peptide Fragments / Q000378:metabolism; D053764:Presenilin-1 / Q000235:genetics*; D013997:Time Factors
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D053327:Apolipoprotein E4; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508853:PSEN1 protein, human; D010446:Peptide Fragments; D053764:Presenilin-1; C075222:amyloid beta-protein (1-42)