title: Choroidal circulatory disturbances associated with retinal angiomatous proliferation on indocyanine green angiography.
abstract: OBJECTIVE
  To investigate the association between choroidal perfusion and retinal angiomatous proliferation (RAP).
  
  
  METHODS
  We performed indocyanine green angiography (ICGA) on 26 eyes of 13 consecutive patients with RAP, and 17 eyes of 17 age-matched controls without age-related macular degeneration. In eyes with RAP and concurrent pigment epithelial detachments (PEDs), we evaluated ICGA images obtained after the PEDs resolved following treatment. Of the 26 eyes in the study group, five eyes with stage 3 RAP or a disciform scar and two eyes that underwent photodynamic therapy were excluded from further evaluation, leaving 19 eyes (11 eyes with stage 1 or 2 RAP and eight fellow eyes without RAP).
  
  
  RESULTS
  Early decreased choroidal filling (EDCF) was observed in nine (81.8%) of 11 eyes with RAP and five (62.5%) of eight fellow eyes without RAP. Late decreased choroidal filling (LDCF) occurred in nine (81.8%) of 11 eyes with RAP and four (50%) of eight fellow eyes without RAP. The incidence of EDCF and LDCF was significantly higher in eyes with RAP than in the control eyes (p < 0.05, p < 0.01, respectively).
  
  
  CONCLUSIONS
  Persistent decreased choroidal filling is common in early-stage RAP. Clinicians should be aware of this, especially when considering treatment.
authors.affiliation: Department of Ophthalmology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iida
authors.forename: Masaaki
authors.initials: M
authors.lastname: Saito
authors.forename: Dai
authors.initials: D
authors.lastname: Nagayama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maruko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002199:Capillary Permeability; D002829:Choroid / Q000098:blood supply*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008268:Macular Degeneration / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D015861:Retinal Neovascularization / Q000503:physiopathology* / Q000601:surgery; D012171:Retinal Vessels / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green