Poststeroid panniculitis.
Poststeroid panniculitis (PSP) is a rare complication of systemic corticosteroid therapy. Clinically, erythematous nodules and indurated plaques develop on the cheeks of children within days or weeks following rapid systemic steroid tapering or cessation. The clinical differential diagnosis of childhood cheek erythema is broad. However, PSP can be identified by clinical history and, if necessary, with a biopsy. Histologically, PSP presents as lobular panniculitis with a mixed inflammatory infiltrates without vasculitis. Needle-shaped clefts within adipocytes are characteristic. The histological differential diagnosis of adipocytes containing needle-shaped crystals is limited. We describe a case of poststeroid panniculitis and discuss the clinicopathological features and pertinent differential diagnoses.
Kwon
Eun Ji
EJ
Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
Emanuel
Patrick O
PO
Gribetz
Canin H
CH
Mudgil
Adarsh V
AV
Phelps
Robert G
RG
D002675:Child, Preschool; D004334:Drug Administration Schedule; D004890:Erythema / Q000175:diagnosis / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000188:drug therapy; D015434:Panniculitis / Q000139:chemically induced* / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects*
D005938:Glucocorticoids; D011239:Prednisolone