The potential antioxidant capacity and angiotensin I-converting enzyme inhibitory activity of Monascus-fermented soybean extracts: evaluation of Monascus-fermented soybean extracts as multifunctional food additives.
The potential antioxidant capacity and angiotensin I-converting enzyme (ACE) inhibitory activity of Monascus-fermented soybean extracts (MFSE) were investigated. The average antioxidant capacities of 70% ethanol extracts from soybean after fermenting for 15 d at 30 degrees C were increased by a 5.2 to 7.4-fold (0.26 mM trolox equivalent/g dry weight, 91.7% 1,1-diphenyl-2-picrylhydrazyl [DPPH] radical scavenging effect at 3 mg/mL) when compared with those of the unfermented soybean extracts (P < 0.01). The potentially significant antioxidant properties of MFSE are associated with its content of bioactive mevinolins (r= 0.85) and isoflavone aglycones (r= 0.98), which were derived from the soybean during Monascus-fermentation. It was also found that the water extract having a molecular mass 1 to 3 kDa showed the highest ACE inhibitory activity (65.3%), which was remarkably greater (6.5 times) than the control.
Pyo
Y-H
YH
Traditional Food Research Division, Korea Food Research Institute, San 46-1, Backhyun-Dong Bundang-Ku Seongnam-City, Gyeonggi-Do, 463-746, Republic of Korea. rosapyo@hotmail.com
Lee
T-C
TC
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005503:Food Additives; D016166:Free Radical Scavengers; D007529:Isoflavones / Q000032:analysis; D008148:Lovastatin / Q000032:analysis; D008970:Molecular Weight; D032741:Monascus / Q000737:chemistry*; D010084:Oxidation-Reduction; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D005503:Food Additives; D016166:Free Radical Scavengers; D007529:Isoflavones; D010936:Plant Extracts; D008148:Lovastatin; D007703:Peptidyl-Dipeptidase A