title: Synthesis and antiviral bioactivities of alpha-aminophosphonates containing alkoxyethyl moieties.
abstract: A simple, efficient, and general method has been developed for the synthesis of various alpha-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new alpha-aminophosphonate derivatives were found to possess moderate to good antiviral activity.
authors.affiliation: Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, PR China. xuyingshu1976@126.com
authors.forename: Yingshu
authors.initials: Y
authors.lastname: Xu
authors.forename: Kai
authors.initials: K
authors.lastname: Yan
authors.forename: Baoan
authors.initials: B
authors.lastname: Song
authors.forename: Gangfang
authors.initials: G
authors.lastname: Xu
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Guiping
authors.initials: G
authors.lastname: Ouyang
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005670:Fusarium / Q000187:drug effects; D008872:Microwaves; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D063065:Organophosphonates