Immunosuppressive agents: effects on glucose and lipid metabolism.
Immunosuppressive therapies are critical elements in successful organ transplantation. Although immunosuppressant drugs are essential in preventing graft rejection and graft maintenance after transplantation, their use is complicated by adverse effects, many being detrimental to graft and even patient long-term survival. Commonly used agents are associated with dysregulated glucose metabolism and dyslipidemia. This article focuses on the effects of immunosuppressive agents on glucose and lipid metabolism. Adrenal effects of these drugs, where known, also are discussed.
Subramanian
Savitha
S
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Box 356426, 1959 NE Pacific Street, Seattle, WA 98195, USA.
Trence
Dace L
DL
D000818:Animals; D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000009:adverse effects; D005938:Glucocorticoids / Q000009:adverse effects; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D050356:Lipid Metabolism / Q000187:drug effects*; D009173:Mycophenolic Acid / Q000009:adverse effects; D020123:Sirolimus / Q000009:adverse effects
D065095:Calcineurin Inhibitors; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid; D005947:Glucose; D020123:Sirolimus