Hyperprolactinemia and delusion of pregnancy.
We describe the case of a 44-year-old woman admitted with mania with psychotic symptoms who presented with delusion of twin pregnancy a month after admission, which temporally correlated with hyperprolactinemia secondary to antipsychotic medication. Modification of antipsychotic medication was associated with fall in serum prolactin and disappearance of delusion of pregnancy. In light of this clinically striking temporal association between hyperprolactinemia and delusion of pregnancy, we review the literature to examine the hypothetical relationship. We highlight the clinical significance of examining the various factors, including antipsychotic-induced hyperprolactinemia, which could trigger the development of delusion of pregnancy.
Ahuja
Niraj
N
Wallsend Community Mental Health Team, Sir G.B. Hunter Memorial Hospital, The Green Wallsend NE28 7PD, UK. niraj.ahuja@nmht.nhs.uk
Vasudev
Kamini
K
Lloyd
Adrian
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D003702:Delusions / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology*; D011247:Pregnancy / Q000523:psychology*; D011555:Pseudopregnancy / Q000523:psychology*; D011618:Psychotic Disorders / Q000188:drug therapy
D014150:Antipsychotic Agents