Molecular and cellular mechanisms of syndecans in tissue injury and inflammation.
The syndecan family of heparan sulfate proteoglycans is expressed on the surface of all adherent cells. Syndecans interact with a wide variety of molecules, including growth factors, cytokines, proteinases, adhesion receptors and extracellular matrix components, through their heparan sulfate chains. Recent studies indicate that these interactions not only regulate key events in development and homeostasis, but also key mechanisms of the host inflammatory response. This review will focus on the molecular and cellular aspects of how syndecans modulate tissue injury and inflammation, and how syndecans affect the outcome of inflammatory diseases in vivo.
Bartlett
Allison H
AH
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 USA.
Hayashida
Kazutaka
K
Park
Pyong Woo
PW
D000818:Animals; D019812:Heparan Sulfate Proteoglycans / Q000096:biosynthesis / Q000737:chemistry; D006801:Humans; D007239:Infections / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D053667:Syndecans / Q000378:metabolism*
D019812:Heparan Sulfate Proteoglycans; D053667:Syndecans