title: The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia.
abstract: BACKGROUND
  We investigated the influence of killer cell immunoglobulin-like receptor (KIR) genes, based on the genotypes of inhibitory or activating KIR, in stem cell recipients with acute myelogenous leukemia and their human leukocyte antigen-matched sibling donors on acute graft-versus host disease (GVHD) after hematopoietic stem cell transplantation.
  
  
  METHODS
  We studied 53 consecutive donor-recipient pairs to determine the impact of KIR genotypes and their bidirectional KIR interactions.
  
  
  RESULTS
  All activating KIR genes in donors were important factors for determining outcome in a manner distinctive for each gene studied. Specifically, the 2DS2 gene and the 2DS4*003 allele were closely correlated with acute GVHD. The 2DS1 gene was associated with a better long-term survival, even if present only in the donor and not the recipient. The 2DS3-2DS5 dual genes were more often involved in a variety of transplant-related complications.
  
  
  CONCLUSIONS
  In conclusion, these factors may help predict transplant outcomes and aid in our understanding of immunogenetic specificity.
authors.affiliation: Catholic Hemopoietic Stem Cell Transplantation Center, Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Hee-Je
authors.initials: HJ
authors.lastname: Kim
authors.forename: Young
authors.initials: Y
authors.lastname: Choi
authors.forename: Woo-Sung
authors.initials: WS
authors.lastname: Min
authors.forename: Tai-Gyu
authors.initials: TG
authors.lastname: Kim
authors.forename: Byung-Sik
authors.initials: BS
authors.lastname: Cho
authors.forename: Sung-Yong
authors.initials: SY
authors.lastname: Kim
authors.forename: Ki-Sung
authors.initials: KS
authors.lastname: Eom
authors.forename: Seok
authors.initials: S
authors.lastname: Lee
authors.forename: Chang-Ki
authors.initials: CK
authors.lastname: Min
authors.forename: Seok-Goo
authors.initials: SG
authors.lastname: Cho
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Jong-Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Chun-Choo
authors.initials: CC
authors.lastname: Kim
mesh_terms: D003586:Cytomegalovirus Infections / Q000453:epidemiology; D005787:Gene Frequency; D005838:Genotype; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008213:Lymphocyte Activation; D011183:Postoperative Complications / Q000453:epidemiology; D054340:Receptors, KIR / Q000235:genetics / Q000276:immunology*; D035781:Siblings; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D054340:Receptors, KIR