title: Mineralization of the deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging.
abstract: OBJECTIVE
  Susceptibility-weighted imaging (SWI) is an advanced MR imaging sequence that can be implemented at high resolution. This sequence can be performed on conventional MR imaging scanners and is very sensitive to mineralization. The purpose of this study was to establish the course of mineralization in the deep gray matter with age by using SWI.
  
  
  METHODS
  We retrospectively reviewed susceptibility-weighted images of 134 patients (age range, 1 to 88 years). Inclusion criteria comprised a normal conventional MR imaging (T1, T2, and fluid-attenuated inversion recovery sequences). We statistically analyzed the relative signal intensities of the globus pallidus, putamen, substantia nigra, caudate nucleus, red nucleus, and thalamus for correlation with age. The putamen was graded according to a modified scale, based on previous work that described a systematic pattern of mineralization with age. Bands of hypointensity in the globus pallidus, dubbed "waves," were also evaluated.
  
  
  RESULTS
  We documented decreasing intensity (ie, increasing mineralization) with age in all deep gray matter areas analyzed. We confirmed the age-related posterolateral to anteromedial progression of mineralization in the putamen. Characteristic medial and lateral bands of mineralization were exhibited in the globus pallidus in all children and young adults older than 3 years. Finally, an increase in the number of "waves" present in the globus pallidus was associated with increased age by category.
  
  
  CONCLUSIONS
  This study documents the course and pattern of mineralization in the deep gray matter with age, as determined by SWI. These findings may play a role in evaluating diseased brains in the future.
authors.affiliation: Department of Medical Imaging, Royal University Hospital, Saskatoon, Saskatchewan, Canada. sheri.harder@saskatoonhealthregion.ca
authors.forename: S L
authors.initials: SL
authors.lastname: Harder
authors.forename: K M
authors.initials: KM
authors.lastname: Hopp
authors.forename: H
authors.initials: H
authors.lastname: Ward
authors.forename: H
authors.initials: H
authors.lastname: Neglio
authors.forename: J
authors.initials: J
authors.lastname: Gitlin
authors.forename: D
authors.initials: D
authors.lastname: Kido
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000166:cytology* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D008903:Minerals