Mechanism of permeation in calcium channels activation by applied magnetic fields.
In this paper, a Brownian dynamics model of cell membrane calcium ion channels exposure to ELF magnetic fields has been proposed for the first time. Based on the model, the permeation of calcium channels activation by applied magnetic fields is given here. The number of opened calcium channel is increase with magnetic fields. The currents of calcium ions in the channel in controls and exposure to ELF magnetic fields are almost the same. These results are consistent with experiments. Thus it can be seen that the current of single calcium channel was nearly unaffected by applied magnetic fields, the increased number of opened calcium channel may be the reason of increased intracellular calcium concentration.
Yu-Hong
Zhang
Z
School of Sciences, Hebei University of Technology, Tianjin, China.
Yong
Zhan
Z
Tong-Jun
Zhao
Z
Ying-Rong
Han
H
Hui
Liu
L
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology* / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000502:physiology / Q000528:radiation effects; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D015640:Ion Channel Gating / Q000502:physiology* / Q000528:radiation effects*; D008954:Models, Biological; D011829:Radiation Dosage
D015220:Calcium Channels; D002118:Calcium