Progress and prospects: gene therapy clinical trials (part 2).
This is the second part of a review summarizing progress and prospects in gene therapy clinical research. Twenty key diseases/strategies are succinctly described and commented on by leaders in the field. This part includes clinical trials for skin diseases, neurological disorders, HIV/AIDS, ornithine transcarbamylase deficiency, alpha(1)-antitrypsin deficiency, haemophilia and cancer.
Alton
Eric
E
Department of Gene Therapy, Emmanuel kaye Building, NHLI, Imperial College, Manresa Road, London, UK.
Ferrari
Stefano
S
Griesenbach
Uta
U
Aiuti
A
A
Bachoud-Lévi
A C
AC
Blesch
A
A
Brenner
M K
MK
Cattaneo
F
F
Chiocca
E A
EA
Gao
G
G
High
K A
KA
Leen
A M
AM
Lemoine
N R
NR
McNeish
I A
IA
Meneguzzi
G
G
Peschanski
M
M
Roncarolo
M G
MG
Strayer
D S
DS
Tuszynski
M H
MH
Waxman
D J
DJ
Wilson
J M
JM
D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques / Q000009:adverse effects / Q000639:trends; D015316:Genetic Therapy / Q000379:methods / Q000639:trends*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000639:trends