title: Urinary epidermal and insulin-like growth factor excretion in autistic children.
abstract: Growth factors have been implicated in the pathogenesis of autism. We have investigated daily urinary excretion of insulin-like growth factor-1 (IGF-1), epidermal growth factor, and insulin-like growth factor binding protein-3 in autistic children (n=34, age 2-5 years) and age-matched control children (n=29). The mean urinary IGF-1 level was lower in the autism group than the control group (p=0.03). Height was normal. These findings suggest altered IGF-1 metabolism in young autistic children. The cause-effect relationship should be examined by longitudinal studies and insulin-like growth factor provocation tests.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. banlar@hacettepe.edu.tr
authors.forename: B
authors.initials: B
authors.lastname: Anlar
authors.forename: F
authors.initials: F
authors.lastname: Oktem
authors.forename: B
authors.initials: B
authors.lastname: Bakkaloglu
authors.forename: M
authors.initials: M
authors.lastname: Haliloglu
authors.forename: H
authors.initials: H
authors.lastname: Oguz
authors.forename: F
authors.initials: F
authors.lastname: Unal
authors.forename: B
authors.initials: B
authors.lastname: Pehlivanturk
authors.forename: B
authors.initials: B
authors.lastname: Gokler
authors.forename: C
authors.initials: C
authors.lastname: Ozbesler
authors.forename: N
authors.initials: N
authors.lastname: Yordam
mesh_terms: D001321:Autistic Disorder / Q000652:urine*; D016022:Case-Control Studies; D002675:Child, Preschool; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000652:urine*; D008297:Male
chemical_list: D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I