title: Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
abstract: Cymbopogon winterianus (Poaceae) is used for its analgesic, anxiolytic and anticonvulsant properties in Brazilian folk medicine. This report aimed to perform phythochemical screening and to investigate the possible anticonvulsant effects of the essential oil (EO) from fresh leaves of C. winterianus in different models of epilepsy. The phytochemical analysis of EO showed presence of geraniol (40.06%), citronellal (27.44%) and citronellol (10.45%) as the main compounds. A behavioral screening demonstrated that EO (100, 200 and 400mg/kg; ip) caused depressant activity on CNS. When administered concurrently, EO (200 and 400mg/kg, ip) significantly reduced the number of animals that exhibited PTZ- and PIC-induced seizures in 50% of the experimental animals (p<0.05). Additionally, EO (100, 200 and 400mg/kg, ip) significantly increased (p<0.05) the latencies of clonic seizures induced by STR. Our results demonstrated a possible activity anticonvulsant of the EO.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, Campus Universitário Prof. Aloísio de Campos, CEP 49100-000 São Cristóvão, SE, Brazil. lucindo_jr@yahoo.com.br
authors.forename: L J
authors.initials: LJ
authors.lastname: Quintans-Júnior
authors.forename: T T
authors.initials: TT
authors.lastname: Souza
authors.forename: B S
authors.initials: BS
authors.lastname: Leite
authors.forename: N M N
authors.initials: NM
authors.lastname: Lessa
authors.forename: L R
authors.initials: LR
authors.lastname: Bonjardim
authors.forename: M R V
authors.initials: MR
authors.lastname: Santos
authors.forename: P B
authors.initials: PB
authors.lastname: Alves
authors.forename: A F
authors.initials: AF
authors.lastname: Blank
authors.forename: A R
authors.initials: AR
authors.lastname: Antoniolli
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000633:toxicity; D010672:Phenytoin / Q000494:pharmacology; D008517:Phytotherapy; D010852:Picrotoxin / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D006109:Poaceae / Q000737:chemistry*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013331:Strychnine / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D003975:Diazepam; D009822:Oils, Volatile; D010433:Pentylenetetrazole; D010672:Phenytoin; D010852:Picrotoxin; D010938:Plant Oils; D013331:Strychnine