Postoperatively administered vancomycin reaches therapeutic concentration in the cerebral spinal fluid of neurosurgical patients.
BACKGROUND
The purpose of this study was to investigate whether vancomycin CSF concentration can reach therapeutic level when administered intravenously after neurosurgical operation.


METHODS
After patients were admitted to the ICU, vancomycin (1.0 g) was injected intravenously, and CSF was collected from either ventricular drainage (VD group, n = 9) or LPD (LPD group, n = 10). The CSF concentration of vancomycin was measured using HPLC.


RESULTS
Peak concentration occurred at 15 to 30 minutes after venoclysis (6.24 +/- 3.46 mg/L in the VD group and 4.49 +/- 3.14 mg/L in the LPD group, respectively) and reached or even exceeded the MIC(90) for MRSA (2 mg/L) and MRCoNS (2 mg/L). Twelve hours later, CSF vancomycin concentration in the VD and LPD groups was 2.55 +/- 1.13 and 2.43 +/- 0.41 mg/L, respectively.


CONCLUSIONS
Neurosurgical operation may disrupt the integrality of BBB so that vancomycin can penetrate through the BBB easily and reach therapeutic concentration of CSF when administered intravenously after operation. This finding suggests that vancomycin can be administered intravenously when used to treat intracranial infection after neurosugical operation.
Wang
Qiang
Q
ICU, Beijing Tiantan Hospital, The Capital Medical University, Beijing 100050, China. ttyywq@163.com
Shi
Zhonghua
Z
Wang
Jiangfei
J
Shi
Guangzhi
G
Wang
Shuo
S
Zhou
Jianxin
J
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D001812:Blood-Brain Barrier / Q000378:metabolism; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000473:pathology / Q000601:surgery; D003399:Craniotomy; D004322:Drainage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D013129:Spinal Puncture; D014640:Vancomycin / Q000008:administration & dosage* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D014640:Vancomycin