Catalytic conjugate additions of nitrogen-, phosphorus-, and carbon-containing nucleophiles by amphoteric vanadyl triflate.
A series of carbamates, amides, N-tosyl amides, (hetero)arenes, and hydrogen phosphines/phosphites has been examined as nucleophiles for (hetero)Michael-type additions to enones and enamides catalyzed by amphoteric vanadyl triflate under mild and neutral conditions. The newly developed C-N, C-P, and C-C bond-formation protocols were carried out smoothly in good to high yields without intervention of any 1,2-additions.
Lin
Yow-Dzer
YD
Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 11650.
Kao
Jun-Qi
JQ
Chen
Chien-Tien
CT