Functionalized chiral ionic liquid catalyzed enantioselective desymmetrizations of prochiral ketones via asymmetric Michael addition reaction.
Functionalized chiral ionic liquids were found to be highly effective and reusable organocatalysts for asymmetric Michael additions of 4-substituted cyclohexanones. The desymmetrization reaction afforded the desired Michael adducts bearing three carbon stereocenters with up to 99% ee.
Luo
Sanzhong
S
Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China. luosz@iccas.ac.cn
Zhang
Long
L
Mi
Xueling
X
Qiao
Yupu
Y
Cheng
Jin-Pei
JP
D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D013237:Stereoisomerism
D003512:Cyclohexanones; D052578:Ionic Liquids; D007659:Ketones; D002244:Carbon