title: Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy.
abstract: Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications, most notable among these being the noble metal nanoparticles. In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and therapeutics. Methods of molecular-specific diagnostics/detection of cancer, including strongly enhanced surface plasmon resonance light-scattering, surface-enhanced emission of gold nanorods and surface-enhanced Raman scattering, are described. We also discuss the plasmonic photothermal therapy of cancer achieved by using the strongly enhanced surface-plasmon resonance absorption of gold nanospheres and nanorods.
authors.affiliation: Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Huang
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Jain
authors.forename: Ivan H
authors.initials: IH
authors.lastname: El-Sayed
authors.forename: Mostafa A
authors.initials: MA
authors.lastname: El-Sayed
mesh_terms: D016503:Drug Delivery Systems / Q000639:trends*; D006046:Gold; D006801:Humans; D050997:Nanomedicine / Q000639:trends*; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D006046:Gold