[Hypnotic effect of Chinese materia medica Cynanchum chinese in mice].
OBJECTIVE
To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.


METHODS
The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.


RESULTS
the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.


CONCLUSIONS
The extract compounds from C. chinese showed inhibitional effect on CNS.
Peng
Xiao-dong
XD
Ningxia Medical College, Yinchuan 750004, China. pengxd@nxmc.edu.cn
Yan
Qian-shun
QS
Wang
Rui
R
Yang
Wei-dong
WD
Peng
Jian-zhong
JZ
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D002725:Chloroform; D031105:Cynanchum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects*; D014867:Water
D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D014867:Water; D002725:Chloroform; D010424:Pentobarbital