Poecillastrin D: a new cytotoxin of the chondropsin class from marine sponge Jaspis serpentina.
Poecillastrin D (2) was isolated together with poecillastrin C (1) from the deep sea sponge, Japsis serpentina. Its structure was elucidated to be that of a macrolide lactam by spectroscopic methods. These compounds showed potent cytotoxicity against various tumor cell lines.
Takemoto
Daisaku
D
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, USA.
Takekawa
Yoshihiko
Y
Soest
Rob W M van
RW
Fusetani
Nobuhiro
N
Matsunaga
Shigeki
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D003603:Cytotoxins; D007769:Lactams; D018942:Macrolides; C519147:poecillastrin C; C526217:poecillastrin D