The Adriamycin rat/mouse model and its importance to the paediatric surgeon.
The teratogenic effect of Adriamycin (doxorubicin) in the rat model, and more recently in the mouse, has provided paediatric surgeons with a reliable, easily reproducible method of studying the embryology and molecular biology for a range of complex congenital anomalies. Concomitantly these animal models have stimulated interest among embryologists for the effect on the notochord, shedding more light on the important organizational role of this structure in the developing embryo. Finally, as more is learnt of the pathogenesis of the various malformations induced by Adriamycin, future therapeutic interventions involving gene therapy, drugs or surgery may arise. This article reviews the establishment of the Adriamycin rat and mouse models, examines their impact on various congenital malformations, and suggests targets for further research.
Gillick
J
J
Children's Researche Centre, Our Lady's Children's Hospital, Crumlin, Ireland.
Mortell
A
A
Dawrant
M
M
Giles
S
S
Bannigan
J
J
Puri
P
P
D000014:Abnormalities, Drug-Induced / Q000473:pathology / Q000601:surgery*; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D002648:Child; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D006801:Humans; D051379:Mice; D051381:Rats
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin