Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment.
Interleukin (IL)-17 is a key inflammatory cytokine in autoimmune disease and may play an important role in the development of experimental autoimmune encephalomyelitis (EAE). In this study, we observed decreased IL-17 and increased IL-27 in EAE rats treated with bone marrow stromal cells (BMSCs). Neutralization of IL-27 resulted in recovery of the BMSCs effect. Adoptive transfer induction of EAE was poor by BMSC-stimulated MNCs, but could be induced by MNCs stimulated by BMSCs under blockade of IL-27 signaling. These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation.
Wang
Jinghua
J
Department of Neurobiology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang 150081, China.
Wang
Guangyou
G
Sun
Bo
B
Li
Hulun
H
Mu
Lili
L
Wang
Qi
Q
Li
Guozhong
G
Shi
Lijun
L
Jin
Lianhong
L
Kostulas
Nikolaos
N
D000818:Animals; D016026:Bone Marrow Transplantation; D016207:Cytokines / Q000096:biosynthesis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism* / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016219:Immunotherapy, Adoptive; D020381:Interleukin-17 / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D017154:Stromal Cells / Q000637:transplantation*
D016207:Cytokines; D020381:Interleukin-17