title: Activity of ceftobiprole compared with those of other agents against Staphylococcus aureus strains with different resistotypes by time-kill analysis.
abstract: Among 10 hospital- and community-acquired Staphylococcus aureus strains with differing methicillin and vancomycin resistotypes, all strains were susceptible to ceftobiprole at MICs <or=2.0 microg/mL, and also to linezolid, tigecycline, and quinupristin/dalfopristin. Ceftobiprole, at 4x MIC, was bactericidal (99.9% killing) against 9 of 10 strains tested at 4x MIC after 24 h. Ceftobiprole also yielded significant activity at earlier periods, with 90% killing of all strains at 2x MIC at 6 and 12 h. Vancomycin was bactericidal against 6 of 8 strains tested at 2x MIC after 24 h. By contrast, linezolid and tigecycline were mainly bacteriostatic, and quinupristin/dalfopristin was bactericidal against 4 of 10 strains at 2x MIC after 24 h.
authors.affiliation: Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
authors.forename: Gengrong
authors.initials: G
authors.lastname: Lin
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C443755:ceftobiprole