Pap smears with reactive cellular changes: a prospective study.
OBJECTIVE
To determine the prevalence of cervical dysplasia and cervical cancer in women with atypical squamous cells (ASCs).


METHODS
A prospective study was conducted at Buddhist Tzu Chi General Hospital from January 1 to September 30, 2003. The primary measurement was cervical dysplasia and the secondary one, cervical cancer. Forty-nine women with Pap smears showing reactive cellular changes were enrolled. All patients underwent colposcopy and biopsy. Endocervical curettage (ECC) was performed before colposcopy. All specimens were reviewed by a pathologist.


RESULTS
Histologic results revealed normal findings in 30 (61%), mild dysplasia in 9 (18.3%), moderate dysplasia in 1 (2%), severe dysplasia in 2 (4%), squamous cell carcinoma in 2 (4%), adenocarcinoma in 1 (2%) and benign lesions in 4 (8.1%).


CONCLUSIONS
Among the subjects with cervical ASCs, 30% and 6% with cervical dysplasia and cervical cancer, respectively, were identified. Colposcopically directed biopsy and ECC are warranted in women with ASC.
Ding
Dah-Ching
DC
Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, and Graduate Institute of Medical Science, School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC. dah1003@yahoo.com.tw
Hsu
Senzan
S
Chen
Sidney S
SS
Hsu
Yung-Hsiang
YH
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D003475:Curettage; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D015995:Prevalence; D011446:Prospective Studies; D012720:Severity of Illness Index; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology; D014626:Vaginal Smears