title: Efficacy of bovine herpesvirus-1 inactivated vaccine against abortion and stillbirth in pregnant heifers.
abstract: OBJECTIVE
  To evaluate the efficacy of an inactivated bovine herpesvirus-1 (BHV-1) vaccine to protect against BHV-1 challenge-induced abortion and stillbirth.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  35 beef heifers.
  
  
  METHODS
  Before breeding, heifers were vaccinated with a commercially available BHV-1 inactivated vaccine SC or IM. The estrous cycle was then synchronized, and heifers were artificially inseminated 30 to 60 days after vaccination. Heifers (n = 21) were challenge inoculated IV at approximately 180 days of gestation with virulent BHV-1. Fourteen control heifers were not vaccinated. Clinical signs of BHV-1 infection were monitored for 10 days following challenge; serologic status and occurrence of abortion or stillbirth were evaluated until time of calving.
  
  
  RESULTS
  18 of 21 (85.7%) heifers that received vaccine were protected from abortion following challenge, whereas all 14 control heifers aborted.
  
  
  CONCLUSIONS
  Results indicated that an inactivated BHV-1 vaccine can protect against abortion resulting from a substantial challenge infection, with efficacy similar to that of modified-live BHV-1 vaccines.
authors.affiliation: Rural Technologies Inc, 1008 32nd Ave, Brookings, SD 57006, USA.
authors.forename: Alicia D
authors.initials: AD
authors.lastname: Zimmerman
authors.forename: Robin E
authors.initials: RE
authors.lastname: Buterbaugh
authors.forename: John M
authors.initials: JM
authors.lastname: Herbert
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Hass
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Frank
authors.forename: Louis G
authors.initials: LG
authors.lastname: Luempert Iii
authors.forename: Christopher C L
authors.initials: CC
authors.lastname: Chase
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control*; D000818:Animals; D002417:Cattle; D005260:Female; D005313:Fetal Death / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007241:Infectious Bovine Rhinotracheitis / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary*; D011446:Prospective Studies; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
chemical_list: D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines