Familial cancer syndromes: catalog with comments.
A catalog of 50 family cancer syndromes is presented, representing all Mendelian modes of inheritance and influential genes on chromosomes 1-20, 22 and the X. Certain trends are emerging such as recurrent involvement of the RecQ family of DNA helicases and somatic overgrowth in the family cancer syndromes. A big question now is: can family cancer syndromes be reliably spotted by primary care clinicians?
Hecht
F
F
Scottsdale, AZ, USA. tbhecht@aol.com
D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000235:genetics*