title: Conjunctival pigmentation in Stevens-Johnson syndrome.
abstract: We report a 29-year-old white woman with conjunctival pigmentation after a Stevens-Johnson syndrome (SJS) episode triggered by sulfasalazine. The patient developed bilateral tarsal and forniceal conjunctiva and black pigmentation. Diagnostic biopsy showed stromal monocyte infiltration consistent with chronic phase SJS and conjunctival pigment of melanic origin that was not due to drug deposition. Treatment with topical steroids and unpreserved artificial tears resulted in improvement of clinical symptoms; however, pigmentation was unchanged after 2 years.
authors.affiliation: Ocular Immunology Unit, IOBA, University of Valladolid, Ramón y Cajal 7, Valladolid, 47005, Spain.
authors.forename: Graciana
authors.initials: G
authors.lastname: Fuentes-Páez
authors.forename: Maria C
authors.initials: MC
authors.lastname: Mendez
authors.forename: Javier
authors.initials: J
authors.lastname: Montañez
authors.forename: Jose M
authors.initials: JM
authors.lastname: Herreras
authors.forename: Maria A
authors.initials: MA
authors.lastname: Saornil
authors.forename: Margarita
authors.initials: M
authors.lastname: Calonge
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003229:Conjunctival Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D010859:Pigmentation Disorders / Q000209:etiology*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D012460:Sulfasalazine / Q000009:adverse effects; D014792:Visual Acuity
chemical_list: D012460:Sulfasalazine