title: Ileal smooth muscle motility depression on rabbit induced by toxin A from Clostridium difficile.
abstract: This study is aimed at elucidating with in vitro experiments the time course of alteration of ileal motility caused by in vivo exposure of ligated loops of ileum to toxin A (1 microg/ligated loop) of Clostridium difficile. In the sham-operated animals no significant alteration of motility was observed. In ligated loops directly injected with toxin A and in loops neighboring those administered with this toxin, a biphasic time course of motility alterations was observed. There was initially (2 h after toxin administration) an increase in spontaneous motility and in the amplitude of maximal contraction induced by potassium and acetylcholine. Afterwards there was a progressive depression of motility, which was more severe in loops directly injected. These results suggested a significant progressive depression of rabbit ileal motility induced by toxin A from C. difficile.
authors.affiliation: Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Paranjana, 1700, Parangaba, Fortaleza, Ceara 60740-000, Brazil.
authors.forename: Crystianne Calado
authors.initials: CC
authors.lastname: Lima
authors.forename: João Luis
authors.initials: JL
authors.lastname: Carvalho-de-Souza
authors.forename: Aldo Angelo Moreira
authors.initials: AA
authors.lastname: Lima
authors.forename: José Henrique
authors.initials: JH
authors.lastname: Leal-Cardoso
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D016360:Clostridioides difficile; D007082:Ileum / Q000187:drug effects*; D016018:Least-Squares Analysis; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011817:Rabbits
chemical_list: D001427:Bacterial Toxins