title: CSF hypocretin-1 levels are normal in multiple-system atrophy.
abstract: Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.
authors.affiliation: Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P.O. Box 9101, 6500 Nijmegan, HB, The Netherlands.
authors.forename: W F
authors.initials: WF
authors.lastname: Abdo
authors.forename: B R
authors.initials: BR
authors.lastname: Bloem
authors.forename: H P H
authors.initials: HP
authors.lastname: Kremer
authors.forename: G J
authors.initials: GJ
authors.lastname: Lammers
authors.forename: M M
authors.initials: MM
authors.lastname: Verbeek
authors.forename: S
authors.initials: S
authors.lastname: Overeem
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000134:cerebrospinal fluid* / Q000145:classification; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins