title: [Physical exercise and insulin resistance: from muscle metabolic physiopathology to therapeutics].
abstract: Insulin resistance which characterises obesity and type 2 diabetes depends on genetic and environmental factors. Sedentarity plays a key role in the development of insulin resistance and skeletal muscle of obese or type 2 diabetes patients shows several abnormalities of carbohydrate and fat metabolism. Exercice training by its beneficial effects on skeletal muscle and particularly on mitochondrial function is efficient to prevent and to treat obesity and type 2 diabetes.
authors.affiliation: Université Montpellier 1, EA 4202, F-34000 Montpellier, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bordenave
authors.forename: Céline
authors.initials: C
authors.lastname: Aguer
authors.forename: Magali
authors.initials: M
authors.lastname: Kitzmann
authors.forename: Jacques
authors.initials: J
authors.lastname: Mercier
mesh_terms: D002245:Carbon Dioxide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020407:Internet; D008019:Life Style; D008055:Lipids / Q000097:blood / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010101:Oxygen Consumption
chemical_list: D008055:Lipids; D002245:Carbon Dioxide