title: [Effects of wearing long-term Ortho-K contact lens on corneal thickness and corneal endothelium].
abstract: OBJECTIVE
  The current study evaluated the response of the cornea to more than 3 years of Ortho-K CL wearing by investigating the changes of corneal thickness and corneal endothelium.
  
  
  METHODS
  One hundred and thirty-two subjects were fitted with Ortho-K CL (Dk 100), which were worn overnight or daily for more than 3 years. Central and para-peripheral corneal thickness and corneal endothelium were measured before and during this period by using A scan pachymeter and non contact specular microscope.
  
  
  RESULTS
  There were no significant changes in corneal thickness (P < 0.05) and corneal endothelial polymegathism and pleomorphism could not be found after long-term wearing of Ortho-K CL (overnight or daily wear).
  
  
  CONCLUSIONS
  This study shows that high Dk Ortho-K CL used for scientific reshaping treatment only induces mild corneal response. Therefore, the Ortho-K CL can be worn safely for long-term control of myopia.
authors.affiliation: Peking University Optometry & Ophthalmology Center, Beijing 100083, China. xpy@b-d.ac.cn
authors.forename: Pei-ying
authors.initials: PY
authors.lastname: Xie
authors.forename: Hui
authors.initials: H
authors.lastname: Chi
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gui-min
authors.initials: GM
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003261:Contact Lenses; D003315:Cornea / Q000473:pathology*; D004728:Endothelium, Corneal / Q000473:pathology*; D004869:Equipment Safety; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000628:therapy; D054158:Orthokeratologic Procedures / Q000295:instrumentation*; D055815:Young Adult