Effects of isomeric fatty acids on reproductive parameters in mice.
OBJECTIVE
The aim of this study was to determine if dietary fatty acids (FA) level or isomeric FA type may affect reproductive parameters in mice.


METHODS
of study Mice were fed for 1 month diets differing in cisFA (cFA) content or type of isomeric FA. Resorption, number of fetuses and placental cytokine expression were determined and sperm acrosome reaction was evaluated after induction by calcium ionophore.


RESULTS
Mice fed high fat diets showed increased fetal resorptions, a decrease in interleukin (IL)-4 placental expression in the first generation and an increase of tumor necrosis factor-alpha (TNF-alpha) in the second generation. In this generation, conjugated linoleic acid (CLA) returned TNF-alpha to normal levels and diminished IL-4 and transforming growth factor-beta (TGF-beta) expressions; males fed transFA (tFA) and CLA showed a lower rate of induced acrosome reaction.


CONCLUSIONS
The amount and type of dietary FA may affect reproductive performance in mice by affecting sperm membrane functionality and placental cytokine production.
Veaute
Carolina
C
Cátedra de Inmunología Básica, Facultad de Bioquímica y Ciencias Biológicas de la Universidad Nacional del Litoral, Santa Fe, Argentina.
Andreoli
María Florencia
MF
Racca
Andrea
A
Bailat
Alejandra
A
Scalerandi
María Victoria
MV
Bernal
Claudio
C
Malan Borel
Ileana
I
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005227:Fatty Acids / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005327:Fetal Resorption / Q000209:etiology / Q000378:metabolism; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D007536:Isomerism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000276:immunology; D012098:Reproduction / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects; D053781:Transforming Growth Factor beta2 / Q000096:biosynthesis / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D004041:Dietary Fats; D005227:Fatty Acids; D053781:Transforming Growth Factor beta2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4