Magnetic resonance imaging (MRI) of inflammation in stroke.
Magnetic resonance imaging (MRI) of inflammation is based on the in vivo magnetic labelling of macrophages, the most abundant cells involved in the post-ischemic inflammatory response, by nanoparticles of iron oxides. Such approach has been successfully applied to study experimental rodent models of focal cerebral ischemia and has proved feasible in pioneer clinical studies. Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeted at inflammation.
Wiart
Marlène
M
Université de Lyon, Creatis-LRMN, UMR CNRS 5220, Inserm U630, INSA de Lyon, Lyon, France. wiart@creatis.insa-lyon.fr
Davoust
Nathalie
N
Pialat
Jean-Baptiste
JB
Berthezène
Yves
Y
Nighoghossian
Norbert
N
D000818:Animals; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D054022:Cerebrum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D003287:Contrast Media / Q000494:pharmacology*; D004195:Disease Models, Animal; D005290:Ferric Compounds / Q000494:pharmacology*; D007249:Inflammation / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D051379:Mice; D018345:Mice, Knockout; D053758:Nanoparticles; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D048068:PPAR-beta / Q000235:genetics / Q000378:metabolism; D011859:Radiography; D020521:Stroke / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy
D003287:Contrast Media; D005290:Ferric Compounds; D047493:PPAR alpha; D048068:PPAR-beta; C000499:ferric oxide