title: AROuSing SIRT1: identification of a novel endogenous SIRT1 activator.
abstract: SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
authors.affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA. everdin@gladstone.ucsf.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
mesh_terms: D000107:Acetylation; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D000077185:Resveratrol; D056564:Sirtuin 1; D037761:Sirtuins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D020536:Enzyme Activators; D009687:Nuclear Proteins; C524448:RPS19BP1 protein, human; D013267:Stilbenes; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins; D000077185:Resveratrol