Distribution of PCDDs, PCDFs and dioxin-like PCBs in the blood, testis and adipose tissue of suckling beef calves.
To determine the distribution of persistent organochlorine compounds in beef cattle, concentrations of 2,3,7,8-substituted PCDDs, PCDFs and dioxin-like PCBs were measured in the blood, testes and adipose tissue of four two-month-old Japanese Black calves. Of 29 congeners analyzed, 19, 20 and 28 were detected in the blood, testes and adipose tissue, respectively, of three or all calves. Total toxic equivalents (TEQs) were similar in the testes and adipose tissue, and approximately two times higher than in the blood on a lipid weight basis (P<0.05). More PCDDs and PCDFs had accumulated in the testes than in adipose tissue (P<0.01), but more dioxin-like PCBs were found in adipose tissue than in the testes (P<0.0001). Accumulation patterns in the testes and adipose tissue varied among the congeners of PCDD and PCDF, whereas the patterns were similar in dioxin-like PCBs. In particular, highly substituted PCDD congeners were detected at high concentrations in the testes but at lower concentrations in adipose tissue compared with other congeners. By contrast, accumulation levels of highly substituted PCDFs were lower in both those tissues than the other congeners. In conclusion, it was demonstrated that PCDDs, PCDFs and dioxin-like PCBs leave the circulation and accumulate in the testes and adipose tissue in bovine calves. It was suggested that congeners of PCDD, especially highly substituted PCDDs, and PCDFs have a tendency to accumulate in the testis and dioxin-like PCB congeners accumulate readily in adipose tissue.
Hirako
Makoto
M
Reproductive Biology and Technology Research Team, National Institute of Livestock and Grassland Science, Tsukuba, Ibaraki 305-0901, Japan. hirakoma@affrc.go.jp <hirakoma@affrc.go.jp>
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000833:Animals, Suckling; D001572:Benzofurans / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D002417:Cattle; D000072338:Dibenzofurans, Polychlorinated; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D005260:Female; D007564:Japan; D008297:Male; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls