Aneuploidy: instigator and inhibitor of tumorigenesis.
Aneuploidy, an aberrant chromosome number, has been recognized as a common characteristic of cancer cells for more than 100 years and has been suggested as a cause of tumorigenesis for nearly as long. However, this proposal had remained untested due to the difficulty of selectively generating aneuploidy without causing other damage. Using Cenp-E heterozygous animals, which develop whole chromosome aneuploidy in the absence of other defects, we have found that aneuploidy promotes tumorigenesis in some contexts and inhibits it in others. These findings confirm that aneuploidy can act oncogenically and reveal a previously unsuspected role for aneuploidy as a tumor suppressor.
Weaver
Beth A A
BA
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Cleveland
Don W
DW
D000782:Aneuploidy; D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000032:analysis / Q000235:genetics; D020090:Chromosome Segregation; D004249:DNA Damage; D006801:Humans; D064246:Mad2 Proteins; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D012097:Repressor Proteins / Q000502:physiology
D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D012097:Repressor Proteins; C068688:centromere protein E