title: [Need for pharmaceutical skill in using displacement of protein binding].
abstract: In pharmacotherapy, to alleviate pains of patients and to provide comforts to patients, pharmacists should improve their pharmaceutical skills of their clinical sense involving pharmaceutical investigational outcomes. Without pharmaceutical skills, pharmacists cannot apply the essence of drug therapies for patients in the most urgent 24 hours treatment. To cope with these drug therapies, we have developed search methods which easily identify the diachronic change of protein binding and the factors in serum (=a new pharmaceutical distribution diagnostic method). This method can speculate diachronic change factors in serum, by monitoring diachronically binding capacities of drug binding sites on human serum albumin (HSA) and alpha(1)-acid glycoprotein (AGP) molecules in patient sera (add each site probe to each patient serum, and measure the free level of each probe by using TDX/FLX analyzer and HPLC detector), and considering the binding capacities and values of HSA, AGP, free fatty acids, bilirubin (Bil) and blood urea nitrogen (BUN) associating with the amounts of uremic toxins laboratory tests. In addition, the diagnostic method could attempt effective administration by using the protein binding displacement of drugs that have a high protein binding capacity and small distribution volume, or high targeting (=the pharmaceutical skill of protein binding displacement). We have practiced pain control of patients with rheumatoid arthritis by the pharmaceutical skill. It is important for pharmacists to master the pharmaceutical skill in pharmacotherapy.
authors.affiliation: Second Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Yoshino, Nobeoka City, Japan. noritotaka@phoenix.ac.jp
authors.forename: Norito
authors.initials: N
authors.lastname: Takamura
authors.forename: Jin
authors.initials: J
authors.lastname: Tokunaga
authors.forename: Etsuo
authors.initials: E
authors.lastname: Chosa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Fujita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Arimori
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism*; D002983:Clinical Competence; D004008:Diclofenac / Q000008:administration & dosage; D004334:Drug Administration Schedule; D015195:Drug Design; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010604:Pharmacy; D011485:Protein Binding
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D004364:Pharmaceutical Preparations; D004008:Diclofenac