Preparation and evaluation of Ibuprofen solid dispersion systems with kollidon particles using a pulse combustion dryer system.
Solid dispersions (SDs) of ibuprofen (IBU) were prepared with four carriers: Kollidon 25, Kollidon 30, Kollidon VA64, and Kollidon CL, using a newly developed pulse combustion dryer system, HYPULCON. Physicochemical properties of the SDs obtained were investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and Fourier transformation IR spectroscopy (FT-IR). Powder X-ray diffraction (PXRD) showed that the crystal diffraction peaks of IBU in SDs disappeared completely, and in differential scanning calorimetry (DSC) curves, the endothermic peaks of IBU in SDs were not observed. Fourier transformation IR spectroscopy (FT-IR) proved that interactions between the drug and carrier existed. These findings demonstrated that IBU changed to an amorphous form in the SDs with the four carriers using the pulse combustion dryer system. The dissolution property of IBU in the SDs was markedly enhanced. The dissolution test showed that after 5 min of dissolution, the concentrations of IBU in the SDs with Kollidon CL as the carrier was 43.81 mug/ml, corresponding to 13.0 times that of pure IBU. So, it is demonstrated that the pulse combustion dryer system is very useful for preparing SDs of IBU with Kollidon of different grades as carriers.
Xu
Lu
L
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Li
San Ming
SM
Sunada
Hisakazu
H
D002152:Calorimetry, Differential Scanning; D003890:Desiccation; D004337:Drug Carriers; D004355:Drug Stability; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
D004337:Drug Carriers; D011205:Povidone; D007052:Ibuprofen