Cytotoxic metabolites from the wood-decayed fungus Xylaria sp. BCC 9653.
Chemical investigation of the wood-decayed fungus Xylaria sp. BCC 9653 has led to the isolation of a new methyl aminobenzoate (1) together with eleven known compounds. The structures were established by analysis of spectroscopic data. Cytochalasin D (2), one of the known metabolites, exhibited potent cytotoxicity against African green monkey kidney fibroblast (Vero) cells with an IC(50) value of 0.19 microM.
Pongcharoen
Wipapan
W
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand.
Rukachaisirikul
Vatcharin
V
Isaka
Masahiko
M
Sriklung
Kanlayanee
K
D010129:4-Aminobenzoic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D015638:Cytochalasin D / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D013057:Spectrum Analysis; D014709:Vero Cells / Q000187:drug effects; D014934:Wood; D013098:Xylariales / Q000737:chemistry*; D062366:para-Aminobenzoates
D000998:Antiviral Agents; D062366:para-Aminobenzoates; D015638:Cytochalasin D; C067182:methyl 4-aminobenzoate; D010129:4-Aminobenzoic Acid