A histone deacetylase regulates addiction.
Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.
Impey
Soren
S
Department of Cell and Developmental Biology, Oregon Health & Sciences University, Portland, OR 97239, USA. impeys@ohsu.edu
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology* / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects / Q000235:genetics; D019970:Cocaine-Related Disorders / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D044127:Epigenesis, Genetic / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006655:Histone Deacetylases / Q000235:genetics*; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000235:genetics
D006657:Histones; C404500:HDAC5 protein, human; D006655:Histone Deacetylases