Murine antigen-induced arthritis.
Antigen induced arthritis is a unilateral T-cell driven model caused by direct injection of an antigen into the knee joint of a FCA preimmunized animal. The chronicity is determined by antigen retention in avascular structures of the joint through charge mediated binding or antibody mediated trapping. Cationicity of the antigen is a prerequisite in this model in the mouse and commercial mBSA is a suitable antigen. Cartilage erosive character is strongly enhanced in the presence of marked antibody titer. Concomitant boosting of the immune response with Bordetella pertussis adds to this. T-cell mediated flares can be induced by local or systemic rechallenge with low dose antigen, and display a strong erosive phenotype.
van den Berg
Wim B
WB
Radboud University Nijmegen Medical Centre, The Netherlands.
Joosten
Leo A B
LA
van Lent
Peter L E M
PL
D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D001169:Arthritis, Experimental / Q000139:chemically induced* / Q000276:immunology* / Q000473:pathology; D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007719:Knee Joint / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology
D000941:Antigens; C029180:methylated bovine serum albumin; D012710:Serum Albumin, Bovine