title: Prevalence of tuberculosis infection in the United States population: the national health and nutrition examination survey, 1999-2000.
abstract: BACKGROUND
  The goal for tuberculosis (TB) elimination in the United States is a TB disease incidence of less than 1 per million U.S. population by 2010, which requires that the latent TB infection (LTBI) prevalence be less than 1% and decreasing.
  
  
  OBJECTIVE
  To estimate the prevalence of LTBI in the U.S. population.
  
  
  METHODS
  Interviews and medical examinations, including tuberculin skin testing (TST), of 7,386 individuals were conducted in 1999-2000 as part of the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of the civilian, noninstitutionalized U.S. population. LTBI was defined as a TST measurement of >/=10 mm. Associations of age, race/ethnicity, sex, poverty, and birthplace were assessed. Results among the 24- to 74-year-old subgroup were compared with NHANES 1971-1972 data.
  
  
  RESULTS
  Estimated LTBI prevalence was 4.2%; an estimated 11,213,000 individuals had LTBI. Among 25- to 74-year-olds, prevalence decreased from 14.3% in 1971-1972 to 5.7% in 1999-2000. Higher prevalences were seen in the foreign born (18.7%), non-Hispanic blacks/African Americans (7.0%), Mexican Americans (9.4%), and individuals living in poverty (6.1%). A total of 63% of LTBI was among the foreign born. Among the U.S. born, after adjusting for confounding factors, LTBI was associated with non-Hispanic African-American race/ethnicity, Mexican American ethnicity, and poverty. A total of 25.5% of persons with LTBI had been previously diagnosed as having LTBI or TB, and only 13.2% had been prescribed treatment.
  
  
  CONCLUSIONS
  In addition to basic TB control measures, elimination strategies should include targeted evaluation and treatment of individuals in high-prevalence groups, as well as enhanced support for global TB prevention and control.
authors.affiliation: Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, Georgia, USA.
authors.forename: Diane E
authors.initials: DE
authors.lastname: Bennett
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: Courval
authors.forename: Ida
authors.initials: I
authors.lastname: Onorato
authors.forename: Tracy
authors.initials: T
authors.lastname: Agerton
authors.forename: Judy D
authors.initials: JD
authors.lastname: Gibson
authors.forename: Lauren
authors.initials: L
authors.lastname: Lambert
authors.forename: Geraldine M
authors.initials: GM
authors.lastname: McQuillan
authors.forename: Brenda
authors.initials: B
authors.lastname: Lewis
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Navin
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D011203:Poverty; D015995:Prevalence; D014374:Tuberculin Test; D014376:Tuberculosis / Q000453:epidemiology* / Q000208:ethnology; D014481:United States / Q000453:epidemiology