[Advances of research on repair of degenerative intervertebral disc with gene transduction].
OBJECTIVE
To introduce the latest advances of research on repair of the degenerative intervertebral disc with gene transduction.


METHODS
The recently-published articles about the treatment of degenerative disc with gene transduction were reviewed, especially the articles published during the recent 5 years about the application of this therapy to regulating the synthesis and degradation of the extracellular matrix of the degenerative intervertebral disc.


RESULTS
The shape and function of the normal intervertebral disc were reported to be closely related to the synthesis and degradation of the extracellular matrix of the intervertebral disc. The extracellular matrix of the intervertebral disc was a target for the gene transduction to repair the degenerative intervertebral disc. There was a great development of the treatment with gene transduction, especially in vector choice, target gene transduction, and transgene regulation and safety.


CONCLUSIONS
The advances of the research have indicated that repair of the degenerative intervertebral disc with gene transduction is a key to curing the disease of the degenerative intervertebral disc.
Zhao
Xianfeng
X
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan 610041, PR China. zhaoxianfeng@msm.com
Liu
Hao
H
D000818:Animals; D000229:Dependovirus / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D013122:Spinal Diseases / Q000628:therapy*; D014161:Transduction, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016212:Transforming Growth Factor beta