title: Mismatch negativity at acute and post-acute phases of first-episode schizophrenia.
abstract: The objective of this study was to evaluate the mismatch negativity (MMN) in patients with first-episode schizophrenia at acute and post-acute phases in order to determine the contribution of trait and/or state features to MMN disturbances in schizophrenia. Subject groups comprised 30 patients with first-episode schizophrenia at the acute phase and 34 healthy controls. Ten patients were neuroleptic-naive during testing at the acute phase. Twenty-one patients were retested at the post-acute phase when their symptoms improved. All patients were taking antipsychotic medication at the post-acute retest session. MMN amplitude of the patients at acute phase did not differ from controls. However, MMN amplitude at post-acute phase was reduced compared to both controls and acute phase. Similar results were obtained when the analyses were confined to neuroleptic-naive patients. The sensory memory functions indexed by MMN seem to be unaffected at the onset of schizophrenia but deteriorated during the post-acute illness phase. MMN reduction at the post-acute phase might be emerged from antipsychotic medication.
authors.affiliation: Department of Physiology, Istanbul Medical Faculty, University of Istanbul, Capa-Istanbul, Turkey. devrim@istanbul.edu.tr
authors.forename: Müge
authors.initials: M
authors.lastname: Devrim-Uçok
authors.forename: H Yasemin
authors.initials: HY
authors.lastname: Keskin-Ergen
authors.forename: Alp
authors.initials: A
authors.lastname: Uçok
mesh_terms: D000161:Acoustic Stimulation; D000208:Acute Disease; D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001288:Attention / Q000502:physiology*; D016022:Case-Control Studies; D003265:Contingent Negative Variation / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D046709:Pattern Recognition, Physiological / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents