Pigment epithelium-derived factor (PEDF) prevents advanced glycation end products (AGEs)-elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties.
PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.
Yamagishi
Sho-ichi
S
Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Japan. shoichi@med.kurume-u.ac.jp
Ueda
Seiji
S
Matsui
Takanori
T
Nakamura
Kazuo
K
Imaizumi
Tsutomu
T
Takeuchi
Masayoshi
M
Okuda
Seiya
S
D004730:Endothelium, Vascular / Q000201:enzymology; D005136:Eye Proteins / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors*; D015843:Serpins / Q000494:pharmacology*; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D017127:Glycation End Products, Advanced; D009414:Nerve Growth Factors; D052250:Nitric Oxide Synthase Type III; D017382:Reactive Oxygen Species; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C496314:NOS3 protein, human