title: Cigarette smoke and dopaminergic system.
abstract: It has been reported that there is an ameliorative effect of cigarette smoking on certain neurological responses and neurodegenerative disorders. The purpose of this study was to examine the neurochemical and neurobehavioral response of cigarette smoke (CS) in the adult male guinea pig brain. Both acute and chronic CS exposure enhanced locomotor behavior and caused a decrease in midbrain dopamine (DA) levels and corresponding increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels. In addition, CS caused a significant increase in the protein levels of the dopamine D1 and D2 receptors. CS caused a significant increase in the binding capacity of the D1 receptor and a significant decrease in the binding capacity of D2. Furthermore, CS caused a significant increase in the binding capacity of the dopamine transporter (DAT). The mechanism by which cigarette smoke exposure increases locomotor activity remains to be elucidated but may include modulation of dopamine neuron activity that emerges after repeated direct smoke exposure.
authors.affiliation: Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville TN 37208, USA.
authors.forename: Leah R
authors.initials: LR
authors.lastname: Miller
authors.forename: Shyamali
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Twum A
authors.initials: TA
authors.lastname: Ansah
authors.forename: Salil K
authors.initials: SK
authors.lastname: Das
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D006168:Guinea Pigs; D007700:Kinetics; D008024:Ligands; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine