Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700.
Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b).
Rudra
Sonali
S
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, R&D III, Plot No. 20, Sector-18, Udyog Vihar Industrial Area, Gurgaon, Haryana 122015, India.
Yadav
Ajay
A
Raja Rao
A V S
AV
Srinivas
A S S V
AS
Pandya
Manisha
M
Bhateja
Pragya
P
Mathur
Tarun
T
Malhotra
Sunita
S
Rattan
Ashok
A
Salman
Mohammed
M
Mehta
Anita
A
Cliffe
Ian A
IA
Das
Biswajit
B
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016984:Enterococcus faecium / Q000187:drug effects; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones