Articular cartilage regeneration with microfracture and hyaluronic acid.
Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-beta3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.
Kang
Sun-Woong
SW
Department of Chemical Engineering, Hanyang University, Seoul, Korea.
Bada
Leela Prasad
LP
Kang
Chang-Seok
CS
Lee
Jae-Sun
JS
Kim
Chul-Hwan
CH
Park
Jung-Ho
JH
Kim
Byung-Soo
BS
D000818:Animals; D054544:Arthroplasty, Subchondral; D002358:Cartilage, Articular / Q000166:cytology / Q000502:physiology*; D005782:Gels; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D011817:Rabbits; D012038:Regeneration; D053782:Transforming Growth Factor beta3 / Q000494:pharmacology*
D005782:Gels; D053782:Transforming Growth Factor beta3; D006820:Hyaluronic Acid