title: Assessment of morphological MRI for pulmonary changes in cystic fibrosis (CF) patients: comparison to thin-section CT and chest x-ray.
abstract: OBJECTIVE
  As pulmonary complications are life limiting in patients with cystic fibrosis (CF), repeated chest imaging [chest x-ray, computed tomography (CT)] is needed for follow up. With the continuously rising life expectancy of CF patients, magnetic resonance imaging (MRI) as a radiation-free imaging modality might become more and more attractive. The goal of this study was to prospectively assess the value of MRI for evaluation of morphologic pulmonary CF-changes in comparison to established imaging modalities.
  
  
  METHODS
  Thirty-one CF patients (19 female, 12 male; mean age 16.7 years) with stable lung disease were examined by MRI: HASTE, coronal/transversal (TR/TE/alpha/TA: infinite/28 ms/180 degrees /18 s), multi-detector computed tomography (MDCT) (30 patients): 120 kV, dose modulated mAs, and chest x-ray (21 patients). Image evaluation: random order, 4 chest radiologists in consensus; chest x-ray: modified Chrispin-Norman score; CT and MRI: modified Helbich score. The maximal attainable score for chest x-ray was 34, for MRI and CT 25. Median scores, Pearson correlation coefficients, Bland-Altman plots, and concordance of MRI to CT on a lobar and segmental basis were calculated.
  
  
  RESULTS
  The median MRI and MDCT scores were 13 (min 3, max 20) respectively 13.5 (min 0, max 20). The median chest x-ray score was 14 (min 5, max 32). Pearson correlation coefficients: MRI/CT = 0.80, P < 0.0001; MRI/chest x-ray = 0.63, P < 0.0018; chest x-ray/CT = 0.75, P < 0.0001. The median lobe related concordance was 80% for bronchiectasis, 77% for mucus plugging, 93%, for sacculation/abscesses, and 100% for collapse/consolidation.
  
  
  CONCLUSIONS
  Morphologic MRI of the lung in CF patients demonstrates comparable results to MDCT and chest x-ray. Because radiation exposure is an issue in CF patients, MRI might have the ability to be used as an appropriate alternative method for pulmonary imaging.
authors.affiliation: Department of Radiology (E010), DKFZ, Heidelberg, Germany. m.puderbach@dkfz.de
authors.forename: Michael
authors.initials: M
authors.lastname: Puderbach
authors.forename: Monika
authors.initials: M
authors.lastname: Eichinger
authors.forename: Julie
authors.initials: J
authors.lastname: Haeselbarth
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Annette
authors.initials: A
authors.lastname: Kopp-Schneider
authors.forename: Siegfried
authors.initials: S
authors.lastname: Tuengerthal
authors.forename: Astrid
authors.initials: A
authors.lastname: Schmaehl
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Christian
authors.initials: C
authors.lastname: Plathow
authors.forename: Matthias
authors.initials: M
authors.lastname: Wiebel
authors.forename: Sueha
authors.initials: S
authors.lastname: Demirakca
authors.forename: Frank-Michael
authors.initials: FM
authors.lastname: Müller
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000293:Adolescent; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D011446:Prospective Studies; D011859:Radiography; D014055:Tomography, Emission-Computed / Q000295:instrumentation