Cluster of Staphylococcus aureus and dengue co-infection in Singapore.
BACKGROUND
Singapore saw a resurgence of dengue infections in 2005. Concurrent bacterial co-infections in dengue is rare.


METHODS
We report a cluster of serious methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia or severe soft tissue infection in 5 epidemiologically linked construction workers presenting with dengue and non-resolving fever.


METHODS
Surgical intervention was indicated in 4 of the 5 patients despite appropriate antistaphylococcal therapy.


RESULTS
All but 1 patient were eventually discharged. Clonality and Panton-Valentine leucocidin genes were not demonstrated. Epidemiological investigations suggested that occupational contact dermatitis could have predisposed the patients to this opportunistic co-infection.


CONCLUSIONS
Clinicians need to be vigilant to unusual manifestations of dengue which may signal a concomitant aetiology.
Chai
Louis Y A
LY
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
Lim
Poh-Lian
PL
Lee
Cheng-Chuan
CC
Hsu
Li-Yang
LY
Teoh
Yee-Leong
YL
Lye
David C B
DC
Krishnan
Prabha
P
Leo
Yee-Sin
YS
D000328:Adult; D016000:Cluster Analysis; D003715:Dengue / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D009790:Occupations; D012846:Singapore / Q000453:epidemiology; D018461:Soft Tissue Infections / Q000635:transmission; D013203:Staphylococcal Infections / Q000150:complications* / Q000453:epidemiology / Q000628:therapy / Q000635:transmission; D013207:Staphylococcal Skin Infections / Q000635:transmission; D013211:Staphylococcus aureus / Q000187:drug effects
D008712:Methicillin