title: Congenital intracranial mesenchymal chondrosarcoma: case report and review of the literature in pediatric patients.
abstract: In this paper we report the 1st case of a congenital intracranial mesenchymal chondrosarcoma in a 2-month-old infant, apparently present at birth. A magnetic resonance image showed a large left parietal solid mass, while microscopy revealed a mixture of undifferentiated small cells and mature hyaline cartilage islands, positive for vimentin, S-100, and CD99. A surgical excision was performed but the patient died after a few weeks as a result of a rapid relapse of the tumor. We also review the pediatric cases (in patients less than 20 years old) of extraskeletal (intracranial) mesenchymal chondrosarcomas of the literature, with a focus on the most recent cytogenetic and immunohistochemical studies.
authors.affiliation: Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: De Cecio
authors.forename: Ilenia
authors.initials: I
authors.lastname: Migliaccio
authors.forename: Jessica
authors.initials: J
authors.lastname: Falleti
authors.forename: Marialaura
authors.initials: M
authors.lastname: Del Basso De Caro
authors.forename: Guido
authors.initials: G
authors.lastname: Pettinato
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000032:analysis; D018211:Chondrosarcoma, Mesenchymal / Q000737:chemistry / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D009418:S100 Proteins; D014746:Vimentin