title: [Simulation of blood flow within the abdominal aorta. Computational fluid dynamics in abdominal aortic aneurysms before and after interventions].
abstract: The goal of numeric analysis of aortic blood flow is to evaluate the mechanisms leading to an aortic aneurysm with regard to the risk of a rupture and to describe the effect of interventional therapy. Numeric analysis is based on virtual models of vascular structures and the physical characteristics of the vessel wall, of blood as fluidum, and the blood flow. Using this information, numeric analysis solves the appropriate equations. The results can be displayed quantitatively and qualitatively. The results of numeric flow simulation show that in abdominal aortic aneurysms the wall pressure, which is of vital importance for the risk of rupture, depends on several factors, one being the location of the intraluminal thrombus. In models of aneurysms after stent grafting, numeric analysis can be used to evaluate factors leading to stent migration. Although numeric analysis of aortic blood flow still has several limitations, recent studies have shown that this method has the potential for improved estimation of the rupture risk of aortic aneurysms in the near future.
authors.affiliation: Institut für Diagnostische Radiologie, Universitätsspital Zürich, Rämistrasse 100, Zürich, Switzerland. thomas.frauenfelder@usz.ch
authors.forename: T
authors.initials: T
authors.lastname: Frauenfelder
authors.forename: E
authors.initials: E
authors.lastname: Boutsianis
authors.forename: H
authors.initials: H
authors.lastname: Alkadhi
authors.forename: B
authors.initials: B
authors.lastname: Marincek
authors.forename: T
authors.initials: T
authors.lastname: Schertler
mesh_terms: D001012:Aorta, Abdominal / Q000502:physiology*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D001019:Aortic Rupture / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D001783:Blood Flow Velocity; D019295:Computational Biology; D003198:Computer Simulation; D005544:Forecasting; D006801:Humans; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D012306:Risk; D015607:Stents