Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer.
Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.
Hidalgo-Pascual
M
M
Servicio de Cirugía General-B, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Galan
J J
JJ
Chaves-Conde
M
M
Ramírez-Armengol
J A
JA
Moreno
C
C
Calvo
E
E
Pelaez
P
P
Crespo
C
C
Ruiz
A
A
Royo
J L
JL
D020413:3' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054377:Chemokine CXCL12 / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012004:Rectal Neoplasms / Q000235:genetics; D012016:Reference Values; D016019:Survival Analysis
D020413:3' Untranslated Regions; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12