title: Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients.
abstract: Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p=<0.01) whereas higher in CSF (p=<0.01) in male>female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.
authors.affiliation: Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune 411043, India.
authors.forename: Anvita
authors.initials: A
authors.lastname: Kale
authors.forename: Sadhana
authors.initials: S
authors.lastname: Joshi
authors.forename: Nilesh
authors.initials: N
authors.lastname: Naphade
authors.forename: Swati
authors.initials: S
authors.lastname: Sapkale
authors.forename: M S V K
authors.initials: MS
authors.lastname: Raju
authors.forename: Anilkumar
authors.initials: A
authors.lastname: Pillai
authors.forename: Henry
authors.initials: H
authors.lastname: Nasrallah
authors.forename: Sahebarao P
authors.initials: SP
authors.lastname: Mahadik
mesh_terms: D000328:Adult; D000367:Age Factors; D000553:Ambulatory Care; D016718:Arachidonic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D004032:Diet; D004281:Docosahexaenoic Acids / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D004912:Erythrocytes / Q000737:chemistry*; D005006:Ethnicity / Q000706:statistics & numerical data; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012737:Sex Factors
chemical_list: D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid