title: Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa.
abstract: The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 microg/ml.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, PR China.
authors.forename: Q-L
authors.initials: QL
authors.lastname: Li
authors.forename: B-G
authors.initials: BG
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: X-P
authors.initials: XP
authors.lastname: Gao
authors.forename: C-Q
authors.initials: CQ
authors.lastname: Li
authors.forename: G-L
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000494:pharmacology; D037602:Isodon / Q000737:chemistry*; D008168:Lung / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D000097123:Rosmarinic Acid
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002109:Caffeic Acids; D002934:Cinnamates; D053630:Depsides; D007703:Peptidyl-Dipeptidase A; D010936:Plant Extracts; D000097123:Rosmarinic Acid; C032773:ethyl caffeate