Immunological response induced by alternated cooling and heating of breast tumor.
A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.
Dong
Jiaxiang
J
Department of Biomedical Engineering, School of Life Science and Technology, Shanghai Jiao Tong University, PR China.
Liu
Ping
P
Zhang
Aili
A
Xu
Lisa X
LX
D000818:Animals; D003080:Cold Temperature; D005260:Female; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods*; D007036:Hypothermia, Induced / Q000379:methods*; D007113:Immunity, Innate / Q000276:immunology* / Q000528:radiation effects*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C