title: Current treatment and management of retinoblastoma.
abstract: Retinoblastoma was traditionally treated with enucleation and external-beam radiotherapy. However, in the past decade, systemic chemotherapy has become the primary globe-salvaging approach. This approach is generally combined with focal treatment, allowing for tumor consolidation following initial chemoreduction. A recently developed classification scheme may improve our ability to predict outcomes with this treatment modality. The Children's Oncology Group has initiated a series of prospective multicenter trials to improve treatment outcomes with systemic chemotherapy.
authors.affiliation: Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030, USA. dgombos@mdanderson.org
authors.forename: Dan S
authors.initials: DS
authors.lastname: Gombos
authors.forename: And Patricia
authors.initials: AP
authors.lastname: Chevez-Barrios
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D012175:Retinoblastoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy*