title: [Carboplatin-etoposide-bleomycine chemotherapy protocol in the treatment of patients with metastatic non-seminomatous germ-cell testicular tumours with good prognosis].
abstract: Fifteen patients with metastatic non-seminomatous germ-cell tumours with good prognosis were treated with carboplatin-etoposide-bleomycine chemotherapy. Patients were followed-up from 8 to 56 months (median 32 months). In 13 patients there was no evidence of the disease and in 2 patients recurred, but recovered after the subsequent secondary chemotherapy (cisplatin-bleomycine-vincristine). Signs and symptoms of toxicity included alopecia in 93% of patients, nausea and vomiting in 40%, while in respect of haematological toxicity, leucopenia was observed in all 15 patients, thrombocytopenia in 80%, and decrease of haemoglobinaemia in 60% of patients. Other toxicities were not observed. Carboplatin-etoposide-bleomycine chemotherapy is effective and little toxic, but a greater number of patients and a longer follow-up are needed for definitive evaluatin of this therapy in the treatment of patients with metastatic non-seminomatous germ-cell testicular tumours with good prognosis.
authors.forename: B
authors.initials: B
authors.lastname: Jeremić
authors.forename: Lj
authors.initials: Lj
authors.lastname: Djurić
authors.forename: S
authors.initials: S
authors.lastname: Djordjević
authors.forename: V
authors.initials: V
authors.lastname: Cirović
authors.forename: Lj
authors.initials: Lj
authors.lastname: Milojević
authors.forename: B
authors.initials: B
authors.lastname: Stanisavljević
authors.forename: M
authors.initials: M
authors.lastname: Matović
authors.forename: Lj
authors.initials: Lj
authors.lastname: Mijatović
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D016190:Carboplatin; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D011379:Prognosis; D013736:Testicular Neoplasms / Q000188:drug therapy*
chemical_list: D001761:Bleomycin; D005047:Etoposide; D016190:Carboplatin