[Significance of the ratio of circulating endothelial cell expressing endothelial lipase and supersensitivity C-reactive protein in prognosis of patients with coronary artery disease].
OBJECTIVE
To evaluate the significance of the ratio of circulating endothelial cell expressing endothelial lipase (EL(+)/CECs) and supersensitivity C-reactive protein (hsCRP) in prognosis of patients with coronary artery disease (CAD).


METHODS
one hundred and seven patients with acute coronary syndrome (ACS), 69 patients with stable angina pain (SAP), and 82 patients in whom CAD was excluded to serve as control were included for study. Blood samples were collected from ulnar vein, and hsCRP was detected, circulating endothelial cells (CECs) were isolated, and the ratio of CEC (EL(+)/CECs) which expressed endothelial lipase (EL) was determined by immunohistochemistry. Over a follow-up period of 6 months, the incidence of cardiac event of all patients was recorded.


RESULTS
In patients with CAD, the EL(+)/CECs and hsCRP were significantly different among groups (P<0.05 or P<0.01). Among them, hsCRP and EL(+)/CECs were higher in ACS group than SAP group patients, whose hsCRP and EL(+)/CECs higher than the control group. The incidence rate of cardiovascular event was significantly higher (all P<0.01) in those whose hsCRP or EL(+)/CECs was higher than those whose with lower average values of these two parameters. Regression analysis indicated that the EL(+)/CECs and hsCRP could be used as the prognostic factor of CAD. The prognostic value of combined determination of EL(+)/CECs and hsCRP was higher.


CONCLUSIONS
The expression of EL in endothelial cells may play a role in the progression of CAD. The EL(+)/CECs may be a good prognostic factor. EL(+)/CECs together with hsCRP may increase the prognostic value.
Fang
Yu-qiang
YQ
Research Institute of Angiocardiopathy, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
Huang
Lan
L
Li
Ai-min
AM
Song
Yao-ming
YM
Jin
Jun
J
Geng
Zhao-hua
ZH
Yu
Xue-jun
XJ
Deng
Meng-yang
MY
D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood*; D042783:Endothelial Cells / Q000201:enzymology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008049:Lipase / Q000097:blood*; D008297:Male; D011379:Prognosis
D002097:C-Reactive Protein; C410382:LIPG protein, human; D008049:Lipase