Phenotypic similarities causing clinical misdiagnosis of pathologically-confirmed sporadic Creutzfeldt-Jakob disease as dementia with Lewy bodies.
A patient fulfilling central, core and supportive clinical diagnostic criteria for dementia with Lewy bodies deteriorated rapidly in the absence of neuroleptic drug treatment, prompting suspicion of a diagnosis of sporadic Creutzfeldt-Jakob disease. At postmortem examination, the brain showed features typical of Creutzfeldt-Jakob disease of the MV1 subtype. We review the phenotypic overlap between dementia with Lewy bodies and Creutzfeldt-Jakob disease which may cause clinical misdiagnosis.
du Plessis
D G
DG
Greater Manchester Neurosciences Centre, Humphrey Booth Building, Hope Hospital, Salford M6 8HD, UK.
Larner
A J
AJ
D000368:Aged; D003072:Cognition Disorders / Q000209:etiology; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology* / Q000523:psychology; D003951:Diagnostic Errors; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology* / Q000523:psychology; D008297:Male; D010641:Phenotype