title: TFA-mediated tandem Friedel-Crafts alkylation/cyclization/hydrogen transfer process for the synthesis of flavylium compounds.
abstract: The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. The reaction was proposed to involve a tandem transformation of Friedel-Crafts alkylation, dehydrative cyclization, intermolecular hydrogen transfer, and hydration. As a multifunctional catalyst, TFA mediated the processes efficiently and cleanly.
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Yan-Chao
authors.initials: YC
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yu-Liang
authors.initials: YL
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000478:Alkylation; D000872:Anthocyanins / Q000138:chemical synthesis*; D003500:Cyclization; D005419:Flavonoids / Q000138:chemical synthesis*; D006859:Hydrogen / Q000737:chemistry*; D008956:Models, Chemical; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000872:Anthocyanins; D005419:Flavonoids; D006859:Hydrogen; D014269:Trifluoroacetic Acid