title: High-viscosity liquid meal accelerates gastric emptying.
abstract: Adding pectin to an elemental formula increases its viscosity through gelatinization, thus presumably preventing gastro-oesophageal reflux and aspiration pneumonia. We investigated the influence of the viscosity of an elemental formula on gastric emptying. Eleven healthy volunteers underwent three tests at intervals of >1 week. After fasting for >8 h, each subject received a test meal (enteral nutrition solution, enteral solution plus pectin, or water). Then gastric emptying (continuous (13)C breath test), gastro-oesophageal intraluminal pressures, oesophageal pH, and blood levels of glucose, insulin and gastrin were all measured simultaneously. The gastric emptying coefficient was significantly increased by adding pectin to enteral nutrition (3.01 +/- 0.10 vs 2.78 +/- 0.10, mean +/- SE, P < 0.05). The antral motility index was also significantly higher with pectin than without at 45-60 min and 60-75 min after the test meal (526 +/- 237 vs 6.5 +/- 4.6 mmHg s(-1) and 448 +/- 173 vs 2.3 +/- 2.3 mmHg s(-1) respectively; P < 0.05). Plasma glucose was significantly higher with pectin than without it at 60 min after ingestion (141.5 +/- 6.03 vs 125.8 +/- 4.69 microM mL(-1), P < 0.05). In healthy individuals, pectin increased the viscosity of enteral nutrition and accelerated gastric emptying.
authors.affiliation: Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: M
authors.initials: M
authors.lastname: Kusano
authors.forename: O
authors.initials: O
authors.lastname: Kawamura
authors.forename: H
authors.initials: H
authors.lastname: Zai
authors.forename: S
authors.initials: S
authors.lastname: Kuribayashi
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: A
authors.initials: A
authors.lastname: Nagoshi
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001944:Breath Tests; D004750:Enteral Nutrition; D005260:Female; D005526:Food, Formulated; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005755:Gastrins / Q000097:blood; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000517:prevention & control; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000097:blood; D008297:Male; D010368:Pectins / Q000008:administration & dosage / Q000494:pharmacology*; D014783:Viscosity
chemical_list: D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D010368:Pectins