Effect of Monascus purpureus-fermented rice on lipidemia and fatty liver in quail.
Monascus purpureus-fermented rice (MR), a preparation which has been shown to be hypolipidemic and antiatherogenic in rabbits and hamsters was fed to quail maintained on a high fat diet to determine if it could influence lipidemia and hepatic steatosis. MR was fed at two levels (0.8 or 1.6 g/kg/d), and compared with a lipoptropic preparation (dongbaogantai 0.6 g/kg/d) and an established hypolipidemic compound (lovastatin 6 mg/kg/d). All the test compounds lowered serum lipids and liver cholesterol levels. Dongbaogantai inhibited hepatic steatosis to the greatest extent (78%), lovastatin inhibited steatosis by 29% and the low and high doses of MR by 25 and 43%, respectively. These serum cholesterol lowering agents have been shown to reduce hepatic steatosis induced by dietary means.
Wei
Wei
W
Department of Biochemical Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.
Li
Changling
C
Wang
Yinye
Y
Kritchevsky
David
D
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D008148:Lovastatin / Q000494:pharmacology; D032741:Monascus / Q000737:chemistry*; D008517:Phytotherapy; D011784:Quail; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D001688:Biological Products; D014280:Triglycerides; C117343:red yeast rice; D002784:Cholesterol; D008148:Lovastatin