title: Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet's disease.
abstract: OBJECTIVE
  The aim of this study was to investigate cochlear involvement in patients with Behçet's disease.
  
  
  METHODS
  Twenty-six Behçet's disease patients (52 ears) and 24 sex and age-matched healthy control subjects (48 ears) were included in the study. Pure-tone audiometry at frequencies 250, 500, 1000, 2000, 4000, 6000 Hz, immittance measures including tympanometry and acoustic reflex testing and DPOAE (distortion product otoacoustic emission) testing were performed in the patients and controls.
  
  
  RESULTS
  A sensorineural hearing loss was found in eight patients (30.7%) as it was bilateral in five and unilateral in three patients. Although no typical audiometric configuration was found, one patient had a flat type audiogram, and the others had a high frequency hearing loss. The DPOAE responses of the patients and controls were significantly different in all frequencies (p<0.05).
  
  
  CONCLUSIONS
  These results indicate that cochlea is affected by damage of outer hair cells in Behçet's disease.
authors.affiliation: Ankara Numune Research and Training Hospital, Otolaryngology Department, Talatpasa Bulvari Samanpazari, Ankara, Turkey. mdagli@hotmail.com
authors.forename: Muharrem
authors.initials: M
authors.lastname: Dagli
authors.forename: Adil
authors.initials: A
authors.lastname: Eryilmaz
authors.forename: Salih
authors.initials: S
authors.lastname: Tanrikulu
authors.forename: Acar
authors.initials: A
authors.lastname: Aydin
authors.forename: Muzeyyen
authors.initials: M
authors.lastname: Gonul
authors.forename: Ulker
authors.initials: U
authors.lastname: Gul
authors.forename: Celil
authors.initials: C
authors.lastname: Gocer
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D015834:Cochlear Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006312:Hearing Loss, Bilateral / Q000175:diagnosis / Q000503:physiopathology; D006316:Hearing Loss, High-Frequency / Q000175:diagnosis / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000503:physiopathology*; D046088:Hearing Loss, Unilateral / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D012016:Reference Values; D055815:Young Adult