title: Gender influence on postprandial lipemia in heterozygotes for familial hypercholesterolemia.
abstract: The aim of this study was to evaluate the influence of gender differences on triglyceride (TG) response after a fatty meal in clinically defined heterozygous (h) patients with familial hypercholesterolemia (FH). Nineteen hFH men were age-matched with an equal number of premenopausal women. Plasma TG was measured before and 2, 4, 6, and 8 hr after a standardized fat load. The men with hFH had a greater body mass index (BMI) than hFH women. An abnormal postprandial response was observed in 63% and 16% of hFH men and women, respectively. The mean TG-area under the curve value was higher in hFH men compared to hFH women. Both gender (p = 0.032) and BMI (p = 0.006) equally affected postprandial TG response, but fasting TG levels (p <0.001) were the main determinant. In summary, hFH men have higher BMI, fasting TG level, and postprandial TG level, compared to age-matched premenopausal hFH women, which may partially explain the earlier onset of coronary heart disease in hFH men.
authors.affiliation: First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. genovefa@kolovou.com
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Anagnostopoulou
authors.forename: Dimitris S
authors.initials: DS
authors.lastname: Damaskos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mihas
authors.forename: Sofia
authors.initials: S
authors.lastname: Mavrogeni
authors.forename: George
authors.initials: G
authors.lastname: Hatzigeorgiou
authors.forename: Theodor
authors.initials: T
authors.lastname: Theodoridis
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Cokkinos
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D006949:Hyperlipidemias / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides