High-fat diet disrupts behavioral and molecular circadian rhythms in mice.
The circadian clock programs daily rhythms and coordinates multiple behavioral and physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent studies indicate that genetic alteration in the core molecular clock machinery can have pronounced effects on both peripheral and central metabolic regulatory signals. Many metabolic systems also cycle and may in turn affect function of clock genes and circadian systems. However, little is known about how alterations in energy balance affect the clock. Here we show that a high-fat diet in mice leads to changes in the period of the locomotor activity rhythm and alterations in the expression and cycling of canonical circadian clock genes, nuclear receptors that regulate clock transcription factors, and clock-controlled genes involved in fuel utilization in the hypothalamus, liver, and adipose tissue. These results indicate that consumption of a high-calorie diet alters the function of the mammalian circadian clock.
Kohsaka
Akira
A
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA.
Laposky
Aaron D
AD
Ramsey
Kathryn Moynihan
KM
Estrada
Carmela
C
Joshu
Corinne
C
Kobayashi
Yumiko
Y
Turek
Fred W
FW
Bass
Joseph
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D056926:CLOCK Proteins; D002490:Central Nervous System / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology
D004041:Dietary Fats; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D056926:CLOCK Proteins; C538944:Clock protein, mouse