Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis.
A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPs were not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase-polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.
Mrazek
F
F
Immunology and Respiratory Medicine, Palacky University, Olomouc, Czech Republic.
Kvezereli
M
M
Garr
E
E
Kubistova
Z
Z
Kriegova
E
E
Fillerova
R
R
Arakelyan
A
A
Ruven
H J T
HJ
Drabek
J
J
van den Bosch
J M M
JM
Kolek
V
V
Welsh
K I
KI
Grutters
J C
JC
du Bois
R M
RM
Petrek
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018153:Czech Republic; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D017463:Receptors, Complement 3b / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics*; D017565:Sarcoidosis, Pulmonary / Q000235:genetics*
C509991:CR1 protein, human; D017463:Receptors, Complement 3b