Thymoma in the offspring of a patient with Isaacs syndrome.
Thymoma is a diagnosis most often made in adults, and is exceedingly rare in children. The diagnosis of a thymoma is often times linked to an autoimmune process, and the association of thymoma and myasthenia gravis in children has been previously reported. We present the first description of a child of a parent with Isaacs syndrome (congenital or acquired neuromyotonia) presenting with a thymoma. In our patient, an evaluation of underlying disease led to a presumptive diagnosis of congenital Isaacs syndrome. This case demonstrates that for the rare child diagnosed with thymoma, evaluation for an underlying neurologic disorder should be considered.
Coulter
Don
D
Division of Hematology-Oncology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7220, USA. dcoulter@unch.unc.edu
Gold
Stuart
S
D000328:Adult; D002648:Child; D016241:Child of Impaired Parents; D006801:Humans; D020386:Isaacs Syndrome; D008297:Male; D011859:Radiography; D013945:Thymoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging