Regulation of NK cell activity by 2B4, NTB-A and CRACC.
2B4, NTB-A and CRACC are members of the recently defined family of SLAM-related receptors. Here we review the role of these receptors for the regulation of Natural Killer cell function and describe the current knowledge about the signal transduction of these receptors. Finally, we critically analyze some controversial data about the function of 2B4 in mouse and man.
Claus
Maren
M
Institute for Immunology, University Heidelberg, INF 305, 69120 Heidelberg, Germany.
Meinke
Stephan
S
Bhat
Rauf
R
Watzl
Carsten
C
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism; D006801:Humans; D007107:Immune System; D007694:Killer Cells, Natural / Q000378:metabolism*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction; D000071176:Signaling Lymphocytic Activation Molecule Family; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
D015703:Antigens, CD; C084093:CD244 protein, human; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C000604060:SLAMF6 protein, human; C448987:SLAMF7 protein, human; D000071176:Signaling Lymphocytic Activation Molecule Family; C000604063:Slamf6 protein, mouse; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1