title: Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.
abstract: Tumours develop in vertebrate organisms endowed with immune systems that are potentially able to eradicate them. Nevertheless, our ever-increasing understanding of the complex interactions between lymphocytes and tumour cells fuels the long-standing hope of developing efficient immunotherapies against cancer. This review focuses on a versatile family of proteins, the major histocompatibility complex class Ib, which has been recently implicated in both the establishment of anti-tumour immune responses and in tumour immune response evasion. We focus on a subset of class Ib proteins, human leukocyte antigen (HLA)-G, Qa-2, CD1d and NKG2D ligands, which bind to either stimulatory or inhibitory receptors expressed on T, natural killer (NK) and NKT lymphocytes, and thereby modulate their anti-tumour activity.
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
authors.forename: Anita Q
authors.initials: AQ
authors.lastname: Gomes
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Correia
authors.forename: Bruno
authors.initials: B
authors.lastname: Silva-Santos
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000276:immunology; D055610:Antigens, CD1d; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008055:Lipids / Q000276:immunology; D008285:Major Histocompatibility Complex; D015166:Monitoring, Immunologic; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; C527085:KLRK1 protein, human; D008055:Lipids; C448919:MHC Ib Qa-2 antigen; D055655:NK Cell Lectin-Like Receptor Subfamily K; D010455:Peptides; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell