Prenatal X-ray exposure and childhood brain tumours: a population-based case-control study on tumour subtypes.
We investigated childhood brain tumours by histological subtype in relation to prenatal X-ray among all children, less than 15 years of age, born in Sweden between 1975 and 1984. For each case, one control was randomly selected from the Medical Birth Register, and exposure data on prenatal X-ray were extracted blindly from antenatal medical records. Additional information on maternal reproductive history was obtained from the Medical Birth Register. We found no overall increased risk for childhood brain tumour after prenatal abdominal X-ray exposure (adjusted odds ratio (OR): 1.02, 95% confidence interval (CI): 0.64-1.62); primitive neuroectodermal tumours had the highest risk estimate (OR: 1.88, 95% CI: 0.92-3.83).
Stålberg
K
K
Department of Women's and Children's Health, Obstetrics and Gynecology, Uppsala University, Uppsala 75185, Sweden. karin.stalberg@kbh.uu.se
Haglund
B
B
Axelsson
O
O
Cnattingius
S
S
Pfeifer
S
S
Kieler
H
H
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D018811:Maternal Exposure / Q000009:adverse effects*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D016017:Odds Ratio; D012042:Registries / Q000706:statistics & numerical data; D013548:Sweden / Q000453:epidemiology; D014965:X-Rays / Q000009:adverse effects*