Orbital metastasis of keratinizing squamous cell cervical carcinoma with giant cells. A case report.
A case of orbital metastasis of cervical keratinizing squamous cell carcinoma is presented. The patient, in remission from primary cervical and ovarian cancers, presented with complaints of left eye ptosis and pain. Examination revealed the presence of a moderately tender mass along the left supra-temporal orbital rim and downward displacement of the left globe. Computed tomography revealed a poorly circumscribed mass with superior lateral wall bone loss. Excised tissue contained invasive, poorly differentiated nests of pan keratin and epithelial membrane antigen-positive squamous cells with numerous pleomorphic multinucleated giant cells. Multiple treatment regimes were unsuccessful, and the patient expired due to disease complications after 3 months.
Gosslee
Jeffrey M
JM
Department of Ophthalmology, Louisiana State University Health Sciences Center, Shreveport, LA 71103-3932, USA.
Misra
Raghunath P
RP
Langford
Marlyn P
MP
Vekovius
Bryan
B
Byrd
William A
WA
Flynn
Steven B
SB
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*
D007633:Keratins