Oral contraceptives and clinical recurrence of human papillomavirus lesions and cervical intraepithelial neoplasia following treatment.
OBJECTIVE
To evaluate the effect of oral contraceptive use on the recurrence rate of human papillomavirus (HPV) lesions and cervical intraepithelial neoplasia (CIN) following ablative or excisional procedures in a long-term follow-up.


METHODS
The study was conducted with 650 oral contraceptive users presenting with HPV lesions and/or CIN, and 670 women who had these lesions but did not use oral contraceptives acted as controls. The participants underwent cytologic evaluations, colposcopy, and direct biopsy, followed by either ablative treatment by laser carbon dioxide vaporization or excision by a loop electrosurgical excision procedure or cold knife conization. They were then followed up for a minimum of 5 years.


RESULTS
The recurrence rates did not differ statistically between the case and control groups.


CONCLUSIONS
Oral contraceptive use was not found to increase the recurrence rate of HPV lesions and/or CIN after ablative or surgical treatment.
Frega
Antonio
A
Department of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy. a.frega@tin.it
Scardamaglia
Paola
P
Piazze
Juan
J
Cerekja
Albana
A
Pacchiarotti
Arianna
A
Verrico
Monica
M
Moscarini
Massimo
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003127:Colposcopy; D019092:Conization / Q000379:methods*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D030361:Papillomavirus Infections / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000601:surgery*
D003278:Contraceptives, Oral, Hormonal