DisSIRTing on LXR and cholesterol metabolism.
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.
Feige
Jerome N
JN
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, 67404 Illkirch, France.
Auwerx
Johan
J
D000818:Animals; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear; D002784:Cholesterol; D037761:Sirtuins