Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage.
Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention.
Dammann
Olaf
O
Division of Newborn Medicine, Department of Pediatrics, Tufts-New England Medical Center, Boston, Mass., USA. odammann@tufts-nemc.org
Bueter
Wolfgang
W
Leviton
Alan
A
Gressens
Pierre
P
Dammann
Christiane E L
CE
D000818:Animals; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D020890:Neuregulin-1 / Q000502:physiology*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism
D020890:Neuregulin-1; D020794:Receptor Protein-Tyrosine Kinases