Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination.
In a recent issue of Molecular Cell, Limbo et al. (2007) identify a new homologous recombination factor, Ctp1 in S. pombe, a homolog of Sae2/Com1 in S. cerevisiae and CtIP in mammals, that operates cooperatively with the MRN complex.
Takeda
Shunichi
S
Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan. stakeda@rg.med.kyoto-u.ac.jp
Nakamura
Kyoko
K
Taniguchi
Yoshihito
Y
Paull
Tanya T
TT
D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008957:Models, Genetic; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
C525888:Ctp1 protein, S pombe; D004268:DNA-Binding Proteins; D029702:Schizosaccharomyces pombe Proteins