[Clinical value of D-dimer in diagnosis and treatment of thrombotic diseases].
OBJECTIVE
To investigate the clinical significance of D-dimer detection in the diagnosis and treatment of thrombotic diseases.


METHODS
Peripheral blood samples were collected from 156 patients with acute cerebral infarction (ACI), 38 patients with deep venous thrombosis (DVT), and 148 patients with acute myocardial infarction (AMI), all under relevant treatment, and 170 healthy examinees. The level of plasma D-dimer was detected by ELISA before and after the treatment.


RESULTS
The positive rates of plasma D-dimer of the ACI, DVT, and AMI patients before treatment were 59.3%, 100.0%, and 61.7% respectively, all significantly higher than that of the health examinees (4.3%, all P < 0.01). And the positive rates of plasma D-dimer decreased rapidly after treatment in the patients of these 3 groups who responded magnificently to thrombolysis treatment (all P < 0.01).


CONCLUSIONS
Increased in most thrombotic patients, the plasma D-dimer level helps diagnose thrombotic diseases early and reflect the efficacy of thrombolysis treatment.
Jin
Yi
Y
Department of Clinical laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xing
Hui
H
Wang
Xiao-Bei
XB
D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000628:therapy
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D