title: A computational model of rat cerebral blood flow using non-uniform rational B-splines.
abstract: Non-Uniform Rational B-splines (NURBS) surfaces can be used for a computer simulation of shapes. Some anatomical models of human or animal structures have been recently developed on that basis. We used positron-emission tomography (PET) and computed tomography (CT) data for NURBS modeling of anatomical structures and isotope uptake in the rat brain. Our simplified model of the rat cerebral blood flow is the first step in a larger project aiming a simulation of PET scans in small animals followed by its validation in vivo.
authors.affiliation: Institute of Cytochemistry and Molecular Pharmacology, 24/14, 6ay Radialnaya, Moscow 115409, Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Pushkin
authors.forename: Guennady I
authors.initials: GI
authors.lastname: Podoprigora
authors.forename: Laurent
authors.initials: L
authors.lastname: Comas
authors.forename: Hatem
authors.initials: H
authors.lastname: Boulahdour
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Cardot
authors.forename: Michel
authors.initials: M
authors.lastname: Baud
authors.forename: Yaroslav R
authors.initials: YR
authors.lastname: Nartsissov
authors.forename: Oleg
authors.initials: O
authors.lastname: Blagosklonov
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D008959:Models, Neurological; D009716:Numerical Analysis, Computer-Assisted; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18