title: Treatment with vacuum-assisted closure and cryo-preserved homologous de-epidermalised dermis of complex traumas to the lower limbs with loss of substance, and bones and tendons exposure.
abstract: Lower-limb injuries with loss of tissue and exposure of bones and tendons are an increasing problem. The condition of the wound locally and the patient in general does not always allow immediate and adequate coverage of the structures exposed by the trauma. Therefore, new therapeutic solutions are needed. A reduction in the time that bones and tendons are exposed is essential to achieve complete healing of bone fractures, with reduced risks of infection and less disabling outcomes. The effectiveness of vacuum-assisted closure (VAC) therapy in supporting wound healing and of cryopreserved homologous de-epidermalised dermis (DED) in providing an effective template for re-epithelialisation has been previously reported. We carried out a study to evaluate the effectiveness of the synergistic and combined use of the two methodologies. Eighteen patients with traumatic loss of tissue in the lower limbs, involving exposure of bone and tendon structures, were enrolled in the study. All participants had local, general contraindications to first-instance reconstructions, or both. All patients received a combination of VAC therapy and DED implants. Granulation tissue was obtained in all wounds, with complete coverage of exposed structures. No infections were detected in the cohort, and all patients were prepared for further necessary reconstructive treatments. In our experience, the combination of VAC therapy and DED could, in selected cases, constitute an effective treatment for complex lower limb traumatic injuries with bone and tendon exposure.
authors.affiliation: Department of General and Specialist Surgery, Plastic Surgery Unit, University of Siena, Polyclinic S Maria alle Scotte, Viale Bracci, Sienna, Italy. cesarebrandi@virgilio.it
authors.forename: C
authors.initials: C
authors.lastname: Brandi
authors.forename: L
authors.initials: L
authors.lastname: Grimaldi
authors.forename: G
authors.initials: G
authors.lastname: Nisi
authors.forename: A
authors.initials: A
authors.lastname: Silvestri
authors.forename: A
authors.initials: A
authors.lastname: Brafa
authors.forename: M
authors.initials: M
authors.lastname: Calabrò
authors.forename: C
authors.initials: C
authors.lastname: D'Aniello
mesh_terms: D000328:Adult; D000368:Aged; D015925:Cryopreservation; D005597:Fractures, Open / Q000601:surgery; D006801:Humans; D007869:Leg Injuries / Q000601:surgery*; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods; D016038:Skin Transplantation / Q000379:methods; D017695:Soft Tissue Injuries / Q000601:surgery; D016896:Treatment Outcome; D014945:Wound Healing