Effects of Lactobacillus acidophilus strain L-55 on experimental allergic rhinitis in BALB/c mice.
We investigated the effect of Lactobacillus acidophilus strain L-55 isolated from infant feces on experimental allergic rhinitis in BALB/c mice. The heat-treated cells of strain L-55 were orally administrated for 4 consecutive weeks to mice sensitized by ovalbumin (OVA), and nasal symptoms (sneezing and nasal rubbing) induced by OVA challenge were evaluated. Strain L-55 at doses of 1 and 10 mg cells/mouse significantly inhibited nasal symptoms by repeated administration over a period of 2 weeks. Furthermore, we measured the level of OVA-specific IgE titers in the serum by passive cutaneous anaphylaxis (PCA) reaction. PCA titers in the sera from mice administrated strain L-55 were significantly lowered compared with the control. These results suggest that oral administration of strain L-55 may be useful for alleviating the nasal symptoms of allergic rhinitis.
Sunada
Yosuke
Y
Fundamental Laboratory, Ohayo Dairy Products Co. Ltd., Okayama, Japan.
Nakamura
Syoji
S
Kamei
Chiaki
C
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007779:Lactobacillus acidophilus; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control*; D012912:Sneezing
D007073:Immunoglobulin E; D010047:Ovalbumin