Novel amphiphilic cyclic oligosaccharides: synthesis and self-aggregation properties.
Novel amphiphilic cyclic disaccharide analogues, in which the saccharide units are connected through stable phosphodiester linkages (CyPLOS, Cyclic Phosphate-Linked OligoSaccharides) and decorated with long lipophilic tentacles at the 2- and 3-OH moieties, have been synthesized. Their propensity to self-aggregation has been investigated by means of 1H and 31P NMR experiments, making it possible to determine for these macrocycles critical aggregation concentration values in the millimolar range.
Coppola
Cinzia
C
Dipartimento di Chimica Organica e Biochimica, Università Federico II di Napoli, Complesso Universitario di Monte S. Angelo, via Cintia, 4, I-80126 Napoli, Italy.
Saggiomo
Vittorio
V
Di Fabio
Giovanni
G
De Napoli
Lorenzo
L
Montesarchio
Daniela
D
D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*
D009844:Oligosaccharides; D013501:Surface-Active Agents