title: Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?
abstract: OBJECTIVE
  Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population.
  
  
  METHODS
  Mitochondrial DNA haplogroups M, N, J and K were studied by PCR-restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons.
  
  
  RESULTS
  There were no statistically significant differences between those with TB and the control group.
  
  
  CONCLUSIONS
  There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.
authors.affiliation: National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Houshmand
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Banoei
authors.forename: Payam
authors.initials: P
authors.lastname: Tabarsi
authors.forename: Mehdi Shafa Shariat
authors.initials: MS
authors.lastname: Panahi
authors.forename: Baharak
authors.initials: B
authors.lastname: Hooshiar Kashani
authors.forename: Golnaz
authors.initials: G
authors.lastname: Ebrahimi
authors.forename: Laleh
authors.initials: L
authors.lastname: Zargar
authors.forename: Parissa
authors.initials: P
authors.lastname: Farnia
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Morris
authors.forename: Davood
authors.initials: D
authors.lastname: Mansouri
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Velayati
authors.forename: Mehdi S
authors.initials: MS
authors.lastname: Mirsaeidi
mesh_terms: D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial