Increased expression of long pentraxin PTX3 in inflammatory bowel diseases.
The aims of this study were to investigate the expression of pentraxin-3 in inflamed gastrointestinal tissue in patients with inflammatory bowel diseases and to elucidate the usefulness of plasma pentraxin-3 level as an inflammation marker in patients with inflammatory bowel diseases. Pentraxin-3 immunoreactivity was found in infiltrating neutrophils and vessels in the inflamed gut. Plasma pentraxin-3 concentration in patients with active inflammatory bowel diseases was significantly higher than that of normal subjects and patients with inactive inflammatory bowel diseases. Significant positive correlations of clinical disease activity with plasma pentraxin-3 concentration and serum CRP concentration were found in patients with inflammatory bowel diseases. Pentraxin-3 is directly produced from the inflamed gut in inflammatory bowel diseases. In conclusion, plasma pentraxin-3 concentration is a useful marker for understanding the disease activity in patients with inflammatory bowel diseases.
Kato
Shingo
S
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Tsujido-machi, Kawagoe, Saitama 359-8513, Japan. skato@saitama-med.ac.jp
Ochiai
Mitsuko
M
Sakurada
Tomoya
T
Ohno
Shino
S
Miyamoto
Kyoko
K
Sagara
Mina
M
Ito
Masataka
M
Takeuchi
Kyoko
K
Imaki
Junko
J
Itoh
Kazuro
K
Yakabi
Koji
K
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D018709:Statistics, Nonparametric; D000099153:Pentraxins
D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins