title: [Can nitrates lead to indirect toxicity?].
abstract: For many years, nitrates have been used, at low dosages, as an additive in salted food. New laws have been promulgated to limit their concentration in water due to increased levels found in soils, rivers and even the aquifer. Although nitrate ions themselves have not toxic properties, bacterial reduction into nitrite ions (occurring even in aqueous medium) can lead to nitrous anhydride, which in turn generates nitrosonium ions. Nitrosium ions react with secondary amine to give nitrosamines, many of which are cancer-inducing agents at very low doses. Opinions on this toxicity are clear-cut and difficult to reconcile. In fact, increased levels are due, in a large part, to the use of nitrates as fertiliéers but also to bacterial transformation of human and animal nitrogenous wastes such as urea.
authors.affiliation: Professeur honoraire à la Faculté des sciences pharmaceutiques et biologiques de Paris Sud, membre de l'Académie nationale de pharmacie. patricia.clement@eps.ap-hop-paris.fr
authors.forename: M
authors.initials: M
authors.lastname: Hamon
mesh_terms: D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects / Q000633:toxicity; D005308:Fertilizers / Q000009:adverse effects / Q000633:toxicity; D006801:Humans; D009566:Nitrates / Q000009:adverse effects / Q000737:chemistry / Q000633:toxicity*; D009602:Nitrosamines / Q000737:chemistry / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D005308:Fertilizers; D009566:Nitrates; D009602:Nitrosamines