Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria.
Four new furanoditerpenoids, fibrauretin A ( 1), fibrauretinoside A ( 2), epi-fibrauretinoside A ( 3), and epi-12-palmatoside G ( 4), and a new ecdysteroid glucoside, fibraurecdyside A ( 5), together with seven known compounds including two furanoditerpenoids ( 6 and 7), an ecdysteroid ( 8), and four quaternary protoberberine alkaloids ( 9- 12) were isolated from the stems of Fibraurea tinctoria. The structures of 1- 5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively.
Su
Chung-Ren
CR
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC.
Ueng
Yune-Fang
YF
Dung
Nguyen Xuan
NX
Vijaya Bhaskar Reddy
M
M
Wu
Tian-Shung
TS
D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029583:Menispermaceae / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014744:Vietnam
D065607:Cytochrome P-450 Enzyme Inhibitors; D004224:Diterpenes; D004791:Enzyme Inhibitors; D005663:Furans; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human