title: Polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and pulmonary tuberculosis in Koreans.
abstract: OBJECTIVE
  Many genetic variations are thought to be risk factors for the development of pulmonary tuberculosis (TB). The association of interferon-gamma (IFN-gamma) and IFN-gamma receptor 1 (IFN-gammaR1) gene polymorphisms with pulmonary TB is controversial. This study examined the association between IFN-gamma and IFN-gammaR1 gene polymorphisms and pulmonary TB among Koreans.
  
  
  METHODS
  Eighty patients with culture-confirmed pulmonary TB and 80 controls were studied. Polymorphisms of the IFN-gamma gene at position +874 were determined using the amplification refractory mutation system PCR assay, and the IFN-gammaR1 gene was genotyped at positions -611, -270, -56 and +95 employing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using genomic DNA.
  
  
  RESULTS
  The genotype and allele frequencies of the IFN-gamma and IFN-gammaR1 gene polymorphisms did not differ significantly between the patients with pulmonary TB and controls.
  
  
  CONCLUSIONS
  The IFN-gamma and IFN-gammaR1 gene polymorphisms do not appear to be responsible for host susceptibility to pulmonary TB in the Korean population.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seooul, Korea.
authors.forename: Jung Hye
authors.initials: JH
authors.lastname: Hwang
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Kim
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Shin-Hye
authors.initials: SH
authors.lastname: Lee
authors.forename: Gee Young
authors.initials: GY
authors.lastname: Suh
authors.forename: O Jung
authors.initials: OJ
authors.lastname: Kwon
authors.forename: Yongick
authors.initials: Y
authors.lastname: Ji
authors.forename: Miyeon
authors.initials: M
authors.lastname: Kang
authors.forename: Duk-Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Won-Jung
authors.initials: WJ
authors.lastname: Koh
mesh_terms: D044466:Asian People / Q000235:genetics*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D007723:Korea; D008297:Male; D017471:Receptors, Interferon / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D000096743:Interferon gamma Receptor
chemical_list: D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor