title: A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation.
abstract: OBJECTIVE
  To evaluate Tocoferol monoglucoside (TMG), a water soluble vit. E. in a phase I trial, as a radiation protector in those undergoing hemi-body radiation for disseminated disease.
  
  
  METHODS
  Patients scheduled to receive modified hemi-body radiation were accrued for the study. Patients not only had disseminated skeletal disease but, were heavily pretreated Seven patients were accrued for the study. Patients received 1 and 2 gms of TMG. 30-40 minutes before hemibody radiation. A dose of 600 cGy was delivered on telecobalt equipment at mid plane. Immediate Toxicities were evaluated as well as response to pain.
  
  
  RESULTS
  All the seven patients underwent radiation uneventfully. There was no drug related toxicity. Pain relief was adequate.
  
  
  CONCLUSIONS
  Tocoferol monoglucoside an effective antioxidant with no significant acute toxicity, when administered in a dose of 1 or 2 gms per oral route. TMG being water-soluble can have global antioxidant and radio protective effects. This needs further clinical evaluation.
authors.affiliation: Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai, India. nagrajh@vsnl.net
authors.forename: N G
authors.initials: NG
authors.lastname: Huilgol
authors.forename: C K K
authors.initials: CK
authors.lastname: Nair
authors.forename: P
authors.initials: P
authors.lastname: Merhotra
authors.forename: V T
authors.initials: VT
authors.lastname: Kagiya
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005960:Glucosides / Q000009:adverse effects / Q000627:therapeutic use*; D017619:Hemibody Irradiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011837:Radiation-Protective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D024505:Tocopherols / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D005960:Glucosides; D011837:Radiation-Protective Agents; C460320:tocopherol monoglucoside; D024505:Tocopherols