title: High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Our aim was to characterize cholesteryl ester transfer protein (CETP) activity in the early phase of acute myocardial infarction (MI).
  
  
  BACKGROUND
  Cholesteryl ester transfer protein catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) donors to apolipoprotein B-containing lipoprotein acceptors.
  
  
  METHODS
  The CETP concentration, lipid profiles, and the rate of cholesteryl ester transfer (CET) from a tracer dose of radiolabeled HDL toward endogenous lipoproteins were determined within 24 h after symptom onset.
  
  
  RESULTS
  Among 347 patients with first MI, CETP concentration, triglycerides, and non-HDL-cholesterol increased across tertiles of the CET rate, whereas HDL-cholesterol, HDL, and LDL sizes decreased gradually. Among lipoprotein donors and acceptors, the best predictors of the CET rate were HDL2b and non-HDL-cholesterol, respectively. Mean age at first MI was 8.5 years lower in the patients from the highest CET tertile than in those in the lowest CET tertile. Diagonal stratification according to both non-HDL-cholesterol and HDL2b tertiles revealed that patients in the highest CET group were 18 years younger than patients in the lowest CET group. Parameters of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad were independently associated with the CET rate.
  
  
  CONCLUSIONS
  In patients with acute MI, high CET rates are characterized by the presence of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad. The association of high CET rates with young age at first MI lends support to a significant contribution of CETP to the accelerated progression of disease among asymptomatic patients.
authors.affiliation: Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, IFR Santé STIC, Dijon, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.forename: David
authors.initials: D
authors.lastname: Masson
authors.forename: Michel
authors.initials: M
authors.lastname: Farnier
authors.forename: Luc
authors.initials: L
authors.lastname: Lorgis
authors.forename: Valérie
authors.initials: V
authors.lastname: Deckert
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Pais de Barros
authors.forename: Catherine
authors.initials: C
authors.lastname: Desrumaux
authors.forename: Pierre
authors.initials: P
authors.lastname: Sicard
authors.forename: Jacques
authors.initials: J
authors.lastname: Grober
authors.forename: Denis
authors.initials: D
authors.lastname: Blache
authors.forename: Philippe
authors.initials: P
authors.lastname: Gambert
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
authors.forename: Laurent
authors.initials: L
authors.lastname: Lagrost
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D012737:Sex Factors
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL