The role of chemokines in neutrophil biology.
Neutrophils are the first to be recruited to a site of infection or a diseased site. Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment. Neutrophils have been considered as effector cells that kill bacteria or destroy affected tissues mainly through the production of reactive oxygen species. Recent studies, however, revealed that neutrophils are involved in the production of chemokines in response to a variety of stimulants including LPS, TNF-alpha, and IFN-gamma, thereby contributing to immunomodulation. These functions are also regulated by selectins during infiltration into various sites. In this review, I summarize the current knowledge on this area and propose that neutrophils are a fascinating target for basic as well as clinical scientists.
Kobayashi
Yoshiro
Y
Division of Molecular Medicine, Dept. of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan. yoshiro@violet.biomol.sci.toho-u.ac.jp
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D016209:Interleukin-8 / Q000378:metabolism; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D016897:Respiratory Burst; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018925:Chemokines; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha