title: Indocyanine green elimination but not bilirubin indicates improvement of graft function during MARS therapy.
abstract: Measurement of indocyanine green plasma disappearance rate (PDR(ICG)) has been suggested as a meaningful liver function parameter. However, there are only very limited data concerning its value in the monitoring of graft dysfunction (GDF) and primary non-function (PNF) especially during molecular absorbent recirculating system (MARS) therapy. This study was therefore performed to evaluate the diagnostic accuracy to detect and monitor GDF with the measurement of the PDR(ICG) in direct comparison with conventional markers like bilirubin and prothrombin time (PT). Of the 19 liver recipients, four patients with GDF and two patients with PNF were treated with 38 MARS cycles. Only PDR(ICG) did reliably indicate liver function between patients with GDF/PNF and patients with sufficient graft function who served as controls. Moreover, receiver operating characteristic analysis showed the highest areas under the curve (AUC) for PDR(ICG) (AUC(PDRICG max): 0.840, AUC(PDRICG max): 0.822), followed by bilirubin (AUC(bilirubin): 0.528) and PT (AUC(PT): 0.546). In contrast to the decrease of the serum bilirubin concentration due to MARS, a noticeable improvement of PDR(ICG) was evident only in patients with GDF. Patients with acute fulminant failure and PNF had significantly lower PDR(ICG) values, which did not improve even during continuous MARS treatments. Conclusively, monitoring of PDR(ICG) is superior to bilirubin and PT measurements to determine the graft function especially in patients with PNF and GDF undergoing MARS therapy.
authors.affiliation: Department of General-, Visceral-, Vascular- and Pediatric Surgery, University Hospital, University of the Saarland, Homburg, Germany. chstsc@uniklinik-saarland.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Scheingraber
authors.forename: Sven
authors.initials: S
authors.lastname: Richter
authors.forename: Dorian
authors.initials: D
authors.lastname: Igna
authors.forename: Matthias
authors.initials: M
authors.lastname: Girndt
authors.forename: Sarah
authors.initials: S
authors.lastname: Flesch
authors.forename: Stefan
authors.initials: S
authors.lastname: Kleinschmidt
authors.forename: Martin K
authors.initials: MK
authors.lastname: Schilling
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood*; D004396:Coloring Agents / Q000493:pharmacokinetics*; D051799:Delayed Graft Function / Q000097:blood / Q000628:therapy*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016060:Sorption Detoxification / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green; D001663:Bilirubin