title: [Kikuchi-Fujimoto's disease and connective tissue disease: a report of three cases].
abstract: BACKGROUND
  Kikuchi-Fujimoto's disease or histiocytic necrotizing lymphadenitis, clinicopathological entity of unknown aetiology, is a rare and benign cause of cervical lymphadenopathies. It can be associated with various auto-immune diseases especially systemic lupus erythematous (SLE) or with some infectious agents.
  
  
  METHODS
  This report describes a survey of three patients who developed Kikuchi's lymphadenitis occurring concomitantly with connective tissue disease: LES in two cases and non determined connective tissue disease in the other case. Comparing the clinical, histopathological and evolutionary findings to the literature allows to identify the main features of this self-limiting disorder: occurrence in young women; clinical presentation with cervical lymphadenopathy in a context of fever and asthenia. The definite diagnosis is usually made through histopathological examination of a lymph node biopsy. Disease course is generally favourable with spontaneous resolution within few weeks. It may be improved with corticosteroid treatment in patients with systemic involvement. Prognosis is related to the associated disease.
  
  
  CONCLUSIONS
  Kikuchi-Fujimoto's disease is a rare and benign cause of cervical lymphadenopathy that could resemble lymphoma, tuberculosis and may be associated with a characterized systemic disease.
authors.affiliation: Service de médecine interne, CHU d'Hédi-Chaker, Sfax 3029, Tunisie. fetenfrikha@yahoo.fr
authors.forename: F
authors.initials: F
authors.lastname: Frikha
authors.forename: S
authors.initials: S
authors.lastname: Marzouk
authors.forename: M
authors.initials: M
authors.lastname: Frigui
authors.forename: M
authors.initials: M
authors.lastname: Jallouli
authors.forename: M
authors.initials: M
authors.lastname: Kechaou
authors.forename: N
authors.initials: N
authors.lastname: Kaddour
authors.forename: T
authors.initials: T
authors.lastname: Boudawara
authors.forename: R
authors.initials: R
authors.lastname: Jlidi
authors.forename: Z
authors.initials: Z
authors.lastname: Bahloul
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003240:Connective Tissue Diseases / Q000150:complications* / Q000175:diagnosis; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D008198:Lymph Nodes / Q000473:pathology