title: [Autologous haematopoietic stem cell transplantation in POEMS syndrome: results in 4 cases].
abstract: POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare disorder characterized by a clonal plasma cell proliferation with a monoclonal protein typically small and lambda restricted. Clinically, this syndrome is a multisystemic disease whose major clinical feature is a peripheral polyneuropathy. A specific treatment for this disease does not exist. We report 4 patients with POEMS syndrome treated with an autologous haematopoietic stem cell transplantation in our centre. All patients had an improvement in neurologic symptoms and other manifestations of the syndrome. The monoclonal component and bone lesions decreased or disappeared. In conclusion, autologous haematopoietic stem cell transplantation is an effective therapy in patients with POEMS syndrome.
authors.affiliation: Instituto de Hematología y Oncología, Servicio de Hematología, Unidad de TPH, Hospital Clínic, IDIBAPS, Universidad de Barcelona, Barcelona, España. pcosta@clinic.ub.es
authors.forename: Pau
authors.initials: P
authors.lastname: Abrisqueta
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rovira
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Cibeira
authors.forename: Rolando
authors.initials: R
authors.lastname: Vallansot
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Gutiérrez
authors.forename: Joan
authors.initials: J
authors.lastname: Bladé
authors.forename: Enric
authors.initials: E
authors.lastname: Carreras
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged; D016878:POEMS Syndrome / Q000601:surgery*; D016896:Treatment Outcome