Coupling reaction of alkyl chlorides with silyl enolates catalyzed by indium trihalide.
Indium(III) halide catalyzed not only the coupling of alkyl chlorides with silyl enolates derived from esters, ketones, and aldehydes to give a variety of alpha-alkylated carbonyl compounds but also one-pot, three-component reactions of aldehyde enolate, alkyl chloride, and allylsilane or alkynylsilane.
Nishimoto
Yoshihiro
Y
Department of Applied Chemistry, Center for Atomic and Molecular Technologies (CAMT), Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yasuda
Makoto
M
Baba
Akio
A
D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000577:Amides; D001965:Bromides; D004952:Esters; D006843:Hydrocarbons, Chlorinated; D007659:Ketones; D012821:Silanes; D007204:Indium