title: Variation in intraocular pressure following application of tropicamide in three different dog breeds.
abstract: OBJECTIVE
  To record intraocular pressure (IOP) of three different dog breeds following administration of one drop of 1% tropicamide.
  
  
  METHODS
  Three dog breeds -- Golden Retrievers (n = 20), Siberian Huskies (n = 20) and English Cocker Spaniels (n = 36) -- were studied.
  
  
  METHODS
  IOPs were measured using a Tonopen following corneal anesthesia with a single drop of 0.5% proxymetacaine. A drop of 0.5% tropicamide was then administered bilaterally and a second IOP measurement was taken 30 min later (postdilation). The difference between the two measurements was considered as the effect of mydriasis on IOP.
  
  
  RESULTS
  Dogs had an average IOP of 14.9 +/- 3.2 mmHg, with 95% confidence limits ranging from 8 to 22 mmHg. There were significant differences between breeds (P < 0.006) with Siberian Huskies having higher IOPs (17.2 +/- 3.7 mmHg) than the other breeds (Spaniels: 14.2 +/- 2.8 mmHg, P < 0.01; Retrievers: 14 +/- 1.9 mmHg, P < 0.001). The majority (60%) of dogs displayed 5 mmHg or less in IOP change postmydriasis. Siberian Huskies showed the highest IOP levels, and also had the greatest variability with dilation.
  
  
  CONCLUSIONS
  Interbreed variability in effect of tropicamide of canine IOP is evident.
authors.affiliation: Department of Optometry & Vision Sciences, University of Melbourne, Parkville, Australia.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Taylor
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Zele
authors.forename: Algis J
authors.initials: AJ
authors.lastname: Vingrys
authors.forename: Robin G
authors.initials: RG
authors.lastname: Stanley
mesh_terms: D000818:Animals; D004285:Dogs; D007429:Intraocular Pressure / Q000187:drug effects*; D009184:Mydriatics / Q000008:administration & dosage / Q000627:therapeutic use*; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D010375:Pedigree; D012016:Reference Values; D014065:Tonometry, Ocular / Q000662:veterinary; D014331:Tropicamide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009184:Mydriatics; D009883:Ophthalmic Solutions; D014331:Tropicamide