[Prenatal diagnosis and treatment of fetal choroid plexus cysts].
OBJECTIVE
To discuss the clinical management and significance of the prenatal diagnosis of Fetal Choroid Plexus Cysts (CPC).


METHODS
From May 2004 to March 2007, 55 cases of fetal CPC diagnosed by B-ultrasound during second trimester were prospectively studied. Each case was studied regarding fetal chromosome karyotype, disappearance weeks of the cyst, the clinical outcome and follow-up results respectively.


RESULTS
The cases were diagnosed during 16 - 25 gestational weeks. The diameters of the cysts varied from 0.2 cm to 2.4 cm. There were 25 cases of bilateral cysts and 30 cases of unilateral or 50 cases of isolated CPC and 5 cases of complicated CPC. The cysts of all cases who continued pregnancy disappeared before 28 weeks. Fetal chromosome karyotypes were obtained in 50 cases. Among them, two cases were 18-trisomy, and one case was 21-trisomy. Five cases were terminated pregnancy because of abnormal chromosome karyotype or malformation during second trimester. One neonate was diagnosed as ventricular septal defect among 50 cases of follow up. Among these six cases, three were from advanced-age pregnant women, five cases were with abnormal fetal structure and five cases were with the diameter of bilateral or unilateral cysts more than 1.0 cm.


CONCLUSIONS
(1) Fetal CPC can be diagnosed during second trimester, and the majority disappear before 28 gestational weeks. (2) High risk factors for fetal abnormal chromosome karyotype may be: advanced-age pregnant women, abnormal structure of fetus, and the diameter of bilateral or unilateral cyst more than 1.0 cm. It is suggested that fetal CPC with the high risks should receive fetal chromosome karyotype test during pregnancy.
Liang
Mei-Ying
MY
Department of Obstetrics, Peking University People's Hospital, Beijing 100044, China. Lmy651129@yahoo.com.cn
Wang
Hong-Bin
HB
Huang
Xin
X
Wei
Yan-Qiu
YQ
D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000196:embryology / Q000235:genetics; D002831:Choroid Plexus; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D003560:Cysts / Q000000981:diagnostic imaging* / Q000196:embryology / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D014314:Trisomy; D016216:Ultrasonography, Prenatal; D055815:Young Adult