Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.
Increased oxidative stress and antioxidant deficit have been suggested to play a major role in isoproterenol-induced myocardial infarction. The present study was designed to evaluate the effect of alpha-mangostin on the antioxidant defense system and lipid peroxidation against isoproterenol-induced myocardial infarction in rats. Induction of rats with ISO (150 mg/kg body weight, ip) for 2 days resulted in a marked elevation in lipid peroxidation, serum marker enzymes (LDH, CPK, GOT, and GPT) and a significant decrease in the activities of endogenous antioxidants (SOD, CAT, GPx, GST, and GSH). Pre-treatment with alpha-mangostin (200 mg/kg of body weight per day) orally for 6 days prior to the ISO administration and 2 days along with ISO administration significantly attenuated these changes when compared to the individual treatment groups. These findings indicate the protective effect of alpha-mangostin on lipid peroxidation and antioxidant tissue defense system during ISO-induced myocardial infarction in rats.
Devi Sampath
Pandima
P
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India.
Vijayaraghavan
Kannan
K
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D029762:Garcinia mangostana / Q000378:metabolism*; D007545:Isoproterenol; D008054:Lipid Peroxides; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D044004:Xanthones / Q000627:therapeutic use*
D000975:Antioxidants; D015415:Biomarkers; D002316:Cardiotonic Agents; D008054:Lipid Peroxides; D044004:Xanthones; C009689:xanthone; D007545:Isoproterenol; C021053:mangostin