Natural antioxidant pedicularioside G inhibits angiogenesis and tumourigenesis in vitro and in vivo.
Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti-angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration-dependent manner. These results suggest that the anti-angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.
Mu
Ping
P
Institute of Biophysics, School of Life Sciences, Lanzhou University, Lanzhou, China.
Gao
Xue
X
Jia
Zhong-Jian
ZJ
Zheng
Rong-Liang
RL
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D057888:Iridoid Glucosides; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D032262:Pedicularis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C079206:pedicularioside