Adherence to lithium in naturalistic settings: results from a nationwide pharmacoepidemiological study.
OBJECTIVE
To estimate adherence to lithium in a nationwide sample of all patients treated with lithium and to characterize adherence according to gender and age.


METHODS
Adherence to lithium was estimated using data obtained by linking Medicinal Product Statistics with the Danish Medical Register on Vital Statistics, identifying all persons who received lithium among the 5.3 million persons living in Denmark during the period 1995 to 2000 inclusive.


RESULTS
The median time to discontinuation of lithium was 181.0 days [95% confidence interval (CI) 135.7-181.0] and 25% of patients stopped treatment with lithium within 45.2 days. Adherence to lithium was significantly poorer for women (135.7 days; 95% CI 90.5-135.7) than for men (316.7 days; 95% CI 271.4-407.1) and for younger (18-39 years) and older (>or=60 years) patients compared to middle-aged patients.


CONCLUSIONS
The results highlight the need for increased focus on long-term adherence to lithium with intensified psychological support, especially among younger and older female patients.
Kessing
Lars Vedel
LV
Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, University of Copenhagen, Denmark. lars.kessing@rh.dk
Søndergård
Lars
L
Kvist
Kajsa
K
Andersen
Per Kragh
PK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002951:Citrates / Q000627:therapeutic use; D003718:Denmark / Q000453:epidemiology; D004363:Drug Utilization; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016651:Lithium Carbonate / Q000627:therapeutic use; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000453:epidemiology; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D017891:Pharmacoepidemiology / Q000706:statistics & numerical data*; D012042:Registries / Q000706:statistics & numerical data; D012737:Sex Factors
D002951:Citrates; D018020:Lithium Compounds; D016651:Lithium Carbonate; C070669:lithium citrate