title: Laparoscopic upper urinary tract surgery for benign and malignant conditions. Does aetiology have an effect on health-related quality of life?
abstract: BACKGROUND
  We present health-related quality of life (HRQoL) data on a cohort of patients undergoing upper urinary tract laparoscopy for a variety of benign and malignant conditions.
  
  
  METHODS
  The Short Form 8 (SF-8) Health Survey is a validated HRQoL questionnaire that calculates scores for physical (PCS8) and mental (MCS8) components of health. It was administered prospectively to 58 patients. Radical nephrectomy or nephroureterectomy was carried out for upper tract malignancy (n = 21). Laparoscopy for benign disease (n = 37) included simple nephrectomy for giant hydronephrosis and small non-functioning kidneys, de-roofing of renal cysts and pyeloplasty. Data were collected before and 6 weeks after surgery.
  
  
  RESULTS
  The mean pre- and postsurgery scores were 45.99; 47.43 and 43.93; 51.54 for PCS8 and MCS8 respectively. With regard to the PCS8 score, there was no significant difference before or after surgery (p = 0.585) or when analysing the benign (p = 0.343) or malignant (p = 0.509) groups individually. The MCS8 score, however, showed a significant increase after surgery (p < 0.0001). This remained significant when analysing just the benign (p < 0.0009) or the malignant (p < 0.0003) groups but neither group was more significant than the other (p = 0.750).
  
  
  CONCLUSIONS
  Laparoscopic upper urinary tract surgery significantly improves mental and does not appear to reduce physical HRQoL in patients regardless of aetiology, 4 weeks following surgery. Interestingly, those operated on for malignant conditions do not have a greater improvement in mental health when compared with benign disease.
authors.affiliation: Department of Urology, Guy's Hospital & KCL School of Medicine, Guy's Hospital, London, UK. prokarurol@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Sahai
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.forename: B
authors.initials: B
authors.lastname: Challacombe
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.forename: P
authors.initials: P
authors.lastname: Dasgupta
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D014570:Urologic Diseases / Q000209:etiology / Q000601:surgery*