title: Efficacy of a topically applied spot-on formulation of a novel insecticide, metaflumizone, applied to cats against a flea strain (KS1) with documented reduced susceptibility to various insecticides.
abstract: A spot-on metaflumizone formulation was evaluated in adult domestic short hair cats to determine its adultidical efficacy against a flea strain that has reduced susceptibility to a number of insecticides. Eight cats served as non-treated controls, eight cats were treated with a metaflumizone formulation at 0.2 ml/kg (40 mg metaflumizone/kg) and eight cats were treated with fipronil 10% w/v-(s)-methoprene 12%w/v at 0.075 ml/kg (7.5-7.7 mg fipronil/kg:9.0-9.2 mg (s)-methoprene/kg). On days -1, 7, 14, 21, 28, 35, and 42 each cat was infested with approximately 100 unfed KS1 cat fleas, Ctenocephalides felis. At approximately 48 h after treatment or infestation, each cat was combed to remove and count live fleas. Treatment with metaflumizone provided > or = 99.3% efficacy for 3 weeks post-treatment and then 97.4, 91.4 and 86.2% efficacy at 4, 5 and 6 weeks post-treatment, respectively. Fipronil-(s)-methoprene provided 99.6% efficacy at 1 week post-treatment and then 97.6, 96.4, 71.3, 22.0 and 13.1% efficacy at weeks 2, 3, 4, 5 and 6, respectively. The reductions in flea numbers were significantly greater for the metaflumizone treatment than for fipronil-(s)-methoprene from 3 to 6 weeks after treatment.
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66503, USA. dryden@vet.ksu.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Dryden
authors.forename: Patricia
authors.initials: P
authors.lastname: Payne
authors.forename: Amy
authors.initials: A
authors.lastname: Lowe
authors.forename: Sara
authors.initials: S
authors.lastname: Mailen
authors.forename: Vicki
authors.initials: V
authors.lastname: Smith
authors.forename: Douglas
authors.initials: D
authors.lastname: Rugg
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D007300:Insect Control / Q000379:methods*; D007306:Insecticides / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use; D011897:Random Allocation; D012664:Semicarbazones / Q000592:standards / Q000627:therapeutic use*; D005423:Siphonaptera / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D011720:Pyrazoles; D012664:Semicarbazones; C528570:metaflumizone; C082360:fipronil