Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.
de Vries
Andrica C H
AC
Stam
Ronald W
RW
Kratz
Christian P
CP
Zenker
Martin
M
Niemeyer
Charlotte M
CM
van den Heuvel-Eibrink
Marry M
MM
D002648:Child; D004252:DNA Mutational Analysis; D006801:Humans; D054429:Leukemia, Myelomonocytic, Juvenile / Q000209:etiology / Q000235:genetics*; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf