title: Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
abstract: The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
authors.affiliation: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Angell
authors.forename: Paul
authors.initials: P
authors.lastname: Bamborough
authors.forename: Anne
authors.initials: A
authors.lastname: Cleasby
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Cockerill
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Jones
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Mooney
authors.forename: Donald O
authors.initials: DO
authors.lastname: Somers
authors.forename: Ann L
authors.initials: AL
authors.lastname: Walker
mesh_terms: D000577:Amides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D000577:Amides; D001713:Biphenyl Compounds; D047428:Protein Kinase Inhibitors; D048051:p38 Mitogen-Activated Protein Kinases