A comparative analysis of kinetic models of erythrocyte glycolysis.
Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions.
du Preez
F B
FB
Triple J Group for Molecular Cell Physiology, Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.
Conradie
R
R
Penkler
G P
GP
Holm
K
K
van Dooren
F L J
FL
Snoep
J L
JL
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000096:biosynthesis; D006019:Glycolysis; D006801:Humans; D008955:Models, Cardiovascular
D000255:Adenosine Triphosphate; D005978:Glutathione