title: Single-lung transplant complicated by unexpected explant carcinoma: a management dilemma.
abstract: Interstitial pneumonia is well known to increase the risk of lung cancer. We describe a young man who underwent single-lung transplantation for confirmed usual interstitial pneumonia and who was unexpectedly found to have multifocal adenocarcinoma in the explanted lung. Induction immunosuppression therapy was decreased and full screening for further tumor development was undertaken. Post-operatively further consolidative changes developed in the remaining native lung and, after diagnosis and staging, a native pneumonectomy was performed for adenocarcinoma. The good early outcome and management dilemmas are discussed, together with a review of the literature.
authors.affiliation: Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridge, UK. ritchie25@hotmail.com
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ritchie
authors.forename: Shafi
authors.initials: S
authors.lastname: Mussa
authors.forename: P
authors.initials: P
authors.lastname: Sivasothy
authors.forename: Susan
authors.initials: S
authors.lastname: Stewart
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery; D016040:Lung Transplantation / Q000276:immunology; D008297:Male; D011013:Pneumonectomy; D011183:Postoperative Complications