[Age characteristics of cadmium content in the organism of poisoned rats with experimental metabolic acidosis].
The paper demonstrates age peculiarities of cadmium content in the liver, kidneys and spleen of 3-month and 18-month rats poisoned by cadmium sulfate. It was registered that the content of cadmium is 266.7 times higher in 3-month old rats, and 141.8 times in 18 months rats in comparison with intact ones. A biological model of introducing 3-month and 18-month rats into the state of metabolic acidosis before and after poisoning with cadmium sulfate was developed. The result of the research showed that changes in acid-base equilibrium of poisoned rats towards metabolic acidosis may influence a decrease of cadmium content in their organisms. Thus, when modeling of metabolic acidosis before the poisoning with cadmium, the content of cadmium decreases in 3-month rats' liver by 21%, in kidneys by 53%; in metabolic acidosis modeling after cadmium poisoning its content decreases, accordingly, by 44% and by 56.5% in comparison with the just poisoned ones. In metabolic experimental acidosis modeling the content of cadmium in 3-month poisoned rats' spleen decreased by 36.5% before and after poisoning. Such changes were also registered in 18-month old rats but to lower extent. Thus, the results of the researches showed more effective correction of cadmium intoxication decrease in the organism of 3-month rats when using the model of acid-base equilibrium change in the organisms of poisoned animals.
Mel'nykova
N M
NM
Voroshylova
N M
NM
D000138:Acidosis / Q000209:etiology / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D019187:Cadmium Compounds / Q000493:pharmacokinetics* / Q000506:poisoning*; D004195:Disease Models, Animal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013431:Sulfates / Q000493:pharmacokinetics* / Q000506:poisoning*
D019187:Cadmium Compounds; D013431:Sulfates; C037123:cadmium sulfate