The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour.
BACKGROUND
Antisocial behaviour has been associated with polymorphic variants in candidate genes and recently also gene-environmental interaction models have been presented. It has been suggested that antisocial behaviour, associated with alcohol consumption in males, is related to a variation in the monoamine oxidase A gene (MAO-A) promoter. Furthermore, platelet MAO-B activity has in several studies been reported to be low in male alcoholics, while this has not been the case with regard to female alcoholics. Aims of the present study were to: (1) investigate possible interactions between the MAO-A polymorphism, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among female adolescents; (2) to investigate if platelet MAO-B enzyme activity interacted with environment to predict female alcohol-related problems.


METHODS
A random sample of 114 female individuals from a total population of 16- and 19-year adolescents from a Swedish county, who volunteered to participate in the study, were interviewed, filled in a questionnaire and a blood sample was drawn.


RESULTS
In contrast to what has been reported in males, presence of the long (4-repeat) variant of the MAO-A gene in females interacted significantly with an unfavourable environment (poor family relations or maltreatment/abuse/sexual abuse) to increase the risk for high scores of alcohol-related problems. Furthermore, females with low platelet MAO-B activity showed an increased risk of alcohol-related problem behaviour in an unfavourable environment.


CONCLUSIONS
Poor psychosocial environment interacts with the high activity MAO-A genotype and low platelet MAO-B enzyme activity to increase vulnerability for female adolescent alcohol-related problem behaviour.
Nilsson
Kent W
KW
Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S-721 89, Västerås, Sweden. kent.nilsson@ltv.se
Wargelius
Hanna-Linn
HL
Sjöberg
Rickard L
RL
Leppert
Jerzy
J
Oreland
Lars
L
D000293:Adolescent; D000328:Adult; D019973:Alcohol-Related Disorders / Q000453:epidemiology* / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D016678:Genome; D005838:Genotype; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000097:blood* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011584:Psychology; D012309:Risk-Taking; D012931:Social Environment; D011795:Surveys and Questionnaires
D017931:DNA Primers; D008995:Monoamine Oxidase