Gene silencing CUTs both ways.
There is extensive transcription throughout the eukaryotic genome resulting in both antisense transcripts from coding regions and cryptic unstable transcripts (CUTs) from intergenic regions. In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deacetylases.
Proudfoot
Nick
N
Sir William Dunn School of Pathology, South Parks Rd., OX1 3RE, University of Oxford, Oxford, UK. nicholas.proudfoot@path.ox.ac.uk
Gullerova
Monika
M
D000818:Animals; D015966:Gene Expression Regulation, Fungal; D020868:Gene Silencing; D006655:Histone Deacetylases / Q000378:metabolism; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D016372:RNA, Antisense; D012331:RNA, Fungal; D006655:Histone Deacetylases