Short-term portal hemodynamic effects of partial splenic embolization for hypersplenism.
OBJECTIVE
The purpose of this study was to investigate the short-term effects of partial splenic embolization (PSE) for hypersplenism on portal hemodynamics and liver function.


METHODS
Thirty-seven patients with hypersplenism were included in this study.


RESULTS
The wedged hepatic venous pressure before and after PSE were 39 +/- 10 and 33 +/- 8 cmH2O, respectively, showing significant change (p < 0.01). The flow volumes of the splenic vein before and after PSE were 477 +/- 200 and 319 +/-187 mL/min, respectively, also showing significant change (p < 0.05). However, the flow volumes of the portal vein before and after PSE were 713 +/- 284 and 684 +/- 152 mL/min, respectively, showing no significant change. The blood laboratory parameters showed no significant change after PSE. PSE damaged neither the portal blood flow volume nor the liver function, although it improved the local hyperdynamic state in the splenic area and thrombocytopenia.


CONCLUSIONS
In conclusion, PSE is a safe and effective treatment for hypersplenism from the portal hemodynamic point of view.
Chikamori
Fumio
F
Department of Surgery, Kuniyoshi Hospital, 1-3-4 Kamimachi, Kochi 780-0901, Japan. chikamo1@i-kochi.or.jp
Kuniyoshi
Nobutoshi
N
Kawashima
Takahiko
T
Takase
Yasuhiro
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006971:Hypersplenism / Q000628:therapy*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011169:Portal Vein / Q000473:pathology; D013154:Spleen / Q000473:pathology*; D013162:Splenic Vein / Q000473:pathology; D013921:Thrombocytopenia; D013997:Time Factors; D016896:Treatment Outcome