Branched organs: mechanics of morphogenesis by multiple mechanisms.
Branching morphogenesis is ubiquitous and important in creating bulk transport systems. Branched ducts can be generated by several different mechanisms including growth, cell rearrangements, contractility, adhesion changes, and other mechanisms. We have developed several models of the mechanics of cleft formation, which we review. We discuss the implications of several candidate mechanisms and review what has been found in models and in experiments.
Lubkin
Sharon R
SR
Department of Mathematics, North Carolina State University, Raleigh, North Carolina 27695-8205, USA.
D000818:Animals; D017209:Apoptosis; D001485:Basement Membrane / Q000166:cytology; D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D048430:Cell Shape; D048429:Cell Size; D005109:Extracellular Matrix / Q000502:physiology; D008648:Mesoderm / Q000166:cytology; D008954:Models, Biological; D009024:Morphogenesis; D014783:Viscosity