title: Antiretroviral therapy in pregnancy: local practice in East London, UK.
abstract: A review of antiretroviral prescribing, mode of delivery and pregnancy outcome was performed to assess local practice against the new British HIV Association guidelines. HIV status prior to pregnancy, antiretroviral medication, viral load, mode of delivery and pregnancy outcome were determined in 95 pregnancies recorded between 2004 and 2006 via retrospective case-note review. In total, 75% (n=71) of pregnancies resulted in live births; 56% (n=53) of pregnancies occurred in women who knew they were HIV positive prior to the current pregnancy; 49% (n=26) of them conceived on antiretroviral therapy (ART). Use of protease-inhibitor-based ART and number of normalvaginal delivery increased and the use of zidovudine (AZT) monotherapy and emergency caesarean section (CS) fell during the study period. In conclusion, there was an increase in vaginal deliveries and a reduction in the number of emergency CSs between 2004 and 2006.
authors.affiliation: Greenway Centre, Newham University Hospital, Glen Road, Plaistow, London E13 8SL, UK. kimberley.forbes@bartsandthelondon.nhs.uk
authors.forename: K M
authors.initials: KM
authors.lastname: Forbes
authors.forename: H
authors.initials: H
authors.lastname: Noble
authors.forename: J
authors.initials: J
authors.lastname: Swan
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Limb
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D019983:Guideline Adherence; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008131:London; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents