The cost effectiveness of intracyctoplasmic sperm injection (ICSI).
OBJECTIVE
To estimate the incremental cost effectiveness of ICSI, and total costs for the population of Australia.


METHODS
Treatment effects for three patient groups were drawn from a published systematic review and meta-analysis of trials comparing fertilisation outcomes for ICSI. Incremental costs derived from resource-based costing of ICSI and existing practice comparators for each patient group.


RESULTS
Incremental cost per live birth for patients unsuited to IVF is estimated between A$8,500 and 13,400. For the subnormal semen indication, cost per live birth could be as low as A$3,600, but in the worst case scenario, there would just be additional incremental costs of A$600 per procedure. Multiplying out the additional costs of ICSI over the relevant target populations in Australia gives potential total financial implications of over A$31 million per annum.


CONCLUSIONS
While there are additional benefits from ICSI procedure, particularly for those with subnormal sperm, the additional cost for the health care system is substantial.
Hollingsworth
Bruce
B
Centre for Health Economics, Faculty of Business and Economics, Monash University, Clayton, 3800, Melbourne, Australia.
Harris
Anthony
A
Mortimer
Duncan
D
D001315:Australia; D003362:Cost-Benefit Analysis; D004542:Ejaculation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000191:economics / Q000628:therapy; D008297:Male; D042282:Microdissection / Q000191:economics; D020554:Sperm Injections, Intracytoplasmic / Q000191:economics*; D053625:Sperm Retrieval / Q000191:economics