HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex.
The chemokine receptor CCR5 is the most important entry coreceptor for HIV-1 in vivo. Its chemokine ligands, including CCL3L1, efficiently inhibit infection by receptor blockade and downmodulation. However, in Nature Immunology, Dolan et al. (2007) present a large human-cohorts study that identifies entry-independent, CCR5-CCL3L1-dependent effects on cell-mediated immunity as a strong correlate of pathogenesis and point to additional influences of the CCR5-CCL3L1 axis on disease progression through undefined mechanisms.
Moore
John P
JP
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10065-4896, USA. jpm2003@med.cornell.edu
Klasse
Per Johan
PJ
D000818:Animals; D019742:Chemokines, CC / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D008024:Ligands; D019713:Receptors, CCR5 / Q000502:physiology*; D014774:Virulence; D014779:Virus Replication
C492767:CCL3L1 protein, human; D019742:Chemokines, CC; D008024:Ligands; D019713:Receptors, CCR5