title: Ischemic preconditioning protects the dog kidney from ischemia-reperfusion injury.
abstract: OBJECTIVE
  To evaluate the effects of unilateral ischemic insult and ischemic preconditioning (IPC) on renal histology in a canine model.
  
  
  METHODS
  30 dogs were randomized into 4 groups. In group A (5 male controls) and group B (5 female controls), ischemia was induced by clamping both left renal arteries for 40 min. Dogs in group C (10 male cases) or group D (10 female cases) underwent 5 min of arterial clamping and 10 min of declamping prior to the final 40-min ischemia induction. Renal biopsy was prepared 48 h later and microscopically examined.
  
  
  RESULTS
  The control groups (A and B) developed 40% frank necrosis, 60% moderate injury, and there was no intact renal tissue in this group with no difference between sexes. The IPC groups (C and D) revealed 55% moderate injury and 45% normal pathology; however, there was no frank necrosis among them. Better IPC protection in the female group was not statistically significant.
  
  
  CONCLUSIONS
  An IPC schedule of 5-min ischemia and 10-min reperfusion improves ischemia-reperfusion injury from subsequent prolonged ischemia in a canine model.
authors.affiliation: Division of Urology, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. E-Mail salehipour@sums.ac.ir
authors.forename: Mehdi
authors.initials: M
authors.lastname: Salehipour
authors.forename: Abdolaziz
authors.initials: A
authors.lastname: Khezri
authors.forename: Ahmad
authors.initials: A
authors.lastname: Monabbati
authors.forename: Hamed
authors.initials: H
authors.lastname: Jalaeian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Kroup
authors.forename: Valiallah
authors.initials: V
authors.lastname: Azizi
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D019194:Ischemic Preconditioning / Q000379:methods*; D007668:Kidney / Q000098:blood supply; D008297:Male; D011336:Probability; D011897:Random Allocation; D012016:Reference Values; D015427:Reperfusion Injury / Q000473:pathology* / Q000517:prevention & control*; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric