A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability.
By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.
Sforza
Stefano
S
Department of Organic and Industrial Chemistry, Viale G.P. Usberti 17a, University Campus, University of Parma, I-43100 - Parma, Italy. stefano.sforza@unipr.it
Tedeschi
Tullia
T
Corradini
Roberto
R
Marchelli
Rosangela
R
D004247:DNA / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D020135:Peptide Nucleic Acids; D004247:DNA; D008239:Lysine