Cytokine therapy for cancer.
This review provides a review of the basic biology of the major cytokines under consideration for use in tumor immunotherapy. The authors also describe the clinical role of cytokine therapy for human tumors, with a focus on melanoma and renal cell carcinoma. Finally, they present details of new cytokines and suggest possible direction for future clinical investigation using new cytokines or combinations of biologic agents. A better understanding of cytokine biology, coupled with new insights into the role of immunoregulation and the microenvironment in patients who have cancer, has provided new therapeutic targets for the treatment of human cancer.
Kim-Schulze
Seunghee
S
The Tumor Immunology Laboratory, Division of Surgical Oncology, 622 West 168th Street, Columbia University, New York, NY 10032, USA.
Taback
Bret
B
Kaufman
Howard L
HL
D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000628:therapy; D003131:Combined Modality Therapy; D016207:Cytokines / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D018121:Receptors, Cytokine / Q000378:metabolism
D019496:Cancer Vaccines; D016207:Cytokines; D018121:Receptors, Cytokine