Assisted reproduction treatment in severe myasthenia gravis.
OBJECTIVE
To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception.


METHODS
Case report and literature review.


METHODS
Tertiary infertility center.


METHODS
A 40-year-old woman affected by severe MG.


METHODS
Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia.


METHODS
Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG.


RESULTS
A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed.


CONCLUSIONS
This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART.
Ricci
Giuseppe
G
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Institute of Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy. ricci@burlo.trieste.it
De Santis
Michela
M
Pagnini
Gloria
G
Tamaro
Leo Fischer
LF
Giolo
Elena
E
Guaschino
Secondo
S
D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000628:therapy*; D009157:Myasthenia Gravis / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome