title: A novel domino-click approach for the synthesis of sugar based unsymmetrical bis-1,2,3-triazoles.
abstract: Aryl or sugar azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted-butynyl-N-aryl or N-glycosyl-1,2,3-bistriazoles in a domino fashion. Upon Cu(I) catalyzed 1,3-dipolar cycloaddition with sugar azides, these compounds afford novel unsymmetrical bis-1,2,3-triazoles in high yields.
authors.affiliation: Synthetic Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180 001, India.
authors.forename: Bhupinder Singh
authors.initials: BS
authors.lastname: Arora
authors.forename: Syed
authors.initials: S
authors.lastname: Shafi
authors.forename: Swarn
authors.initials: S
authors.lastname: Singh
authors.forename: Tabasum
authors.initials: T
authors.lastname: Ismail
authors.forename: H M Sampath
authors.initials: HM
authors.lastname: Kumar
mesh_terms: D001386:Azides / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D001386:Azides; D002241:Carbohydrates; D014230:Triazoles; D003300:Copper