Deliberate self-poisoning with tiagabine: an unusual toxidrome.
Tiagabine is an anticonvulsant acting by selective inhibition of neuronal and glial gamma-aminobutyric acid uptake, resulting in increased gamma-aminobutyric acid-mediated inhibition in the brain. Few reports in the literature describe the clinical course of severe tiagabine intoxication. A 44-year-old woman presented after deliberate self-poisoning with 100 tiagabine 15 mg tablets (1,500 mg; 25 mg/kg). Serum tiagabine level was 4,600 microg/L (1,725 mmol/L) at presentation, 20 times levels associated with therapeutic dosing. Intoxication was manifested by profuse vomiting, coma, myoclonus, generalized rigidity, bradycardia, hypertension, hypersalivation and generalized piloerection within 2 h of ingestion. The patient was intubated and management was supportive. Coma lasted until 10 h post-ingestion, but recovery was complicated by severe agitated delirium lasting 12 h. The patient recovered fully within 26 h of ingestion. Tiagabine deliberate self-poisoning was associated with the rapid onset of coma and an unusual toxidrome. Recovery, although complicated by agitated delirium, was complete within 26 h.
Forbes
Richard A
RA
Intensive Care Unit, Royal Perth Hospital, Perth, WA, Australia.
Kalra
Harish
H
Hackett
L Peter
LP
Daly
Frank F S
FF
D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D003693:Delirium / Q000139:chemically induced; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D009557:Nipecotic Acids / Q000506:poisoning*; D013406:Suicide, Attempted; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine