title: New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY).
abstract: Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected.
authors.affiliation: Department Biologia Animal, Vegetal i Ecologia, Unitat d'Antropologia Biològica, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. cbaro@imim.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Baró
authors.forename: Marta
authors.initials: M
authors.lastname: Salido
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Laura
authors.initials: L
authors.lastname: Astier
authors.forename: Alicia
authors.initials: A
authors.lastname: Domingo
authors.forename: Isabel
authors.initials: I
authors.lastname: Granada
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millà
authors.forename: Ana
authors.initials: A
authors.lastname: Carrió
authors.forename: Dolors
authors.initials: D
authors.lastname: Costa
authors.forename: Elisa
authors.initials: E
authors.lastname: Luño
authors.forename: Jesús Ma
authors.initials: JM
authors.lastname: Hernández
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Lourdes
authors.initials: L
authors.lastname: Florensa
authors.forename: Ana
authors.initials: A
authors.lastname: Ferrer
authors.forename: Antonio
authors.initials: A
authors.lastname: Salar
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.forename: Carles
authors.initials: C
authors.lastname: Besses
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005803:Genes, Immunoglobulin; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6; D013160:Splenic Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6