Viral evasion of autophagy.
Restriction of both bacterial and viral pathogen growth by autophagy has been documented in vitro. In this issue of Cell Host & Microbe, Orvedahl et al. demonstrate for the first time that inhibition of autophagy by a viral gene product is essential for neurovirulence of herpesviruses.
Münz
Christian
C
Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. munzc@rockefeller.edu
D017951:Antigen Presentation; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001343:Autophagy; D000071186:Beclin-1; D005075:Biological Evolution; D006801:Humans; D007107:Immune System / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D012328:RNA Viruses / Q000235:genetics / Q000472:pathogenicity; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins; D014764:Viral Proteins