title: A new method for evaluating the performance of depth-of-hypnosis indices - the D-value.
abstract: An alternative statistic, the D-value, is presented for the evaluation of the performance of EEG-based depth-of-hypnosis measures against the Observers' Assessment of Alertness/Sedation scale. The measures considered here are spectral entropy, approximate entropy, Lempel-Ziv complexity and Higuchi fractal dimension. The study is based on recordings from 45 patients, divided into three groups of 15 recordings each. Patients of Group I received no remifentanil while patients of Groups II and III received 2 and 4 ng/ml effect compartment controlled remifentanil. All the patients received stepwise increased dose of propofol. The study shows that the D-value is a promising and flexible statistic for the evaluation of the discriminative power of the EEG measures with respect to the OAA/S scale. The D-value indicates well the dependence of the performance of the measures on the EEG frequency band as well as on remifentanil concentration.
authors.affiliation: Pori unit of Tampere University of Technology, Pori, Finland. tarmo.lipping@tut.fi
authors.forename: Tarmo
authors.initials: T
authors.lastname: Lipping
authors.forename: Rain
authors.initials: R
authors.lastname: Ferenets
authors.forename: Eric P
authors.initials: EP
authors.lastname: Mortier
authors.forename: Michel M F
authors.initials: MM
authors.lastname: Struys
mesh_terms: D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid; D000758:Anesthesia; D018686:Anesthetics, Intravenous; D003627:Data Interpretation, Statistical; D054810:Deep Sedation; D004569:Electroencephalography / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol