title: Chemical biology that controls DNA structure and function.
abstract: All genetic information, which is necessary for life, is written in 3 billion base pairs of DNA. Sequence-dependent local DNA conformations are also thought to play an important role in gene expression. Many diseases, including cancer, and hereditary and viral diseases, can now be understood at the DNA sequence and structure level. Therefore, direct control of the expression level of a specific gene would provide a promising approach for knowledge-based therapy. In this presentation I focus on our long-term efforts in controlling of structure and function of DNA by chemical biological approach.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto 606-8502, Japan. hs@kuchem.kyoto-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D054856:G-Quadruplexes; D020868:Gene Silencing; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D018906:Antineoplastic Agents, Alkylating; D009757:Nylons