title: Mass spectrometry analysis of new chemical entities for pharmaceutical discovery.
abstract: In this Section, we review the applications of mass spectrometry for the analysis and purification of new chemical entities (NCEs) for pharmaceutical discovery. Since the speed of synthesis of NCEs has dramatically increased over the last few years, new high throughput analytical techniques have been developed to keep pace with the synthetic developments. In this Section, we review both novel, as well as modifications of commonly used mass spectrometry techniques that have helped increase the speed of the analytical process. Part of the review is devoted to the purification of NCEs, which has undergone significant development in recent years, and the close integral association between characterization and purification to drive high throughput operations. At the end of the Section, we review potential future directions based on promising and exciting new developments.
authors.affiliation: ArQule, Inc., Woburn, MA, USA.
authors.forename: Annette S
authors.initials: AS
authors.lastname: Fang
authors.forename: Xiusheng
authors.initials: X
authors.lastname: Miao
authors.forename: Peter W
authors.initials: PW
authors.lastname: Tidswell
authors.forename: Marc H
authors.initials: MH
authors.lastname: Towle
authors.forename: Wolfgang K
authors.initials: WK
authors.lastname: Goetzinger
authors.forename: James N
authors.initials: JN
authors.lastname: Kyranos
mesh_terms: D002845:Chromatography / Q000379:methods*; D015195:Drug Design; D004345:Drug Industry / Q000639:trends*; D017022:Flow Injection Analysis / Q000639:trends*; D013058:Mass Spectrometry / Q000639:trends*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations