title: Pattern-reversal electroretinograms and visual evoked potentials in retinitis pigmentosa.
abstract: OBJECTIVE
  To analyze pattern electroretinograms (PERGs) and pattern visual evoked potentials (PVEPs) in retinitis pigmentosa (RP) patients.
  
  
  METHODS
  PERGs and PVEPs were recorded in 106 eyes of 53 RP patients. A RETIport system was used for stimulation and recording.
  
  
  RESULTS
  Reproducible PERGs were found in 17 (32%) of the patients, from only one eye in 4 of the 17 patients. We failed to record a normal PERG in any patient. All 53 patients gave reproducible PVEPs. The patients could be divided into three groups according to the waveform of the response. In the first group (n = 17), all patients produced PVEPs with a characteristic, triphasic shape, but with smaller amplitudes. In the second group (n = 16), the PVEPs displayed doubled P100 peaks, with components separated by about 50 ms. The recordings in the third group (n = 20) were broad in shape and characterized by a greatly increased N70-N170 latency difference and decreased amplitudes.
  
  
  CONCLUSIONS
  In the population of RP patients, different types of PVEP waveform alterations can be observed. The appearance of both the responses with decreased amplitude and those with broad, doubled P100 waves might reflect differences in central retinal degeneration. The significance and pathological background of these PVEP alterations need further investigations.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Szeged, Korányi rkpt. 10-11, Pf: 427, 6720 Szeged, Hungary. janaky@opht.szote.u-szeged.hu
authors.forename: Márta
authors.initials: M
authors.lastname: Janáky
authors.forename: Andrea
authors.initials: A
authors.lastname: Pálffy
authors.forename: Gyöngyi
authors.initials: G
authors.lastname: Horváth
authors.forename: Gábor
authors.initials: G
authors.lastname: Tuboly
authors.forename: György
authors.initials: G
authors.lastname: Benedek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000503:physiopathology*; D014786:Vision Disorders / Q000503:physiopathology; D014792:Visual Acuity; D014793:Visual Cortex / Q000503:physiopathology*; D014794:Visual Fields