Leishmanicidal activity of passifloricin A and derivatives.
Several natural and hemisyntetic passifloricins were assayed against Leishmania panamensis amastigotes. High leishmanicidal activity as well as toxicity was observed. The structure of a new compound is also reported.
Cardona
Wilson
W
Universidad de Antioquia, Instituto de Quimica, P. O. Box 1226, Medellín, Colombia.
Quiñones
Winston
W
Echeverri
Fernando
F
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007928:Lethal Dose 50; D021261:Parasitic Sensitivity Tests; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D020298:U937 Cells
D000981:Antiprotozoal Agents; D011753:Pyrones; C433046:passifloricin A