title: Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.
abstract: A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-Gu, Daejeon, Republic of Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Song
authors.forename: Navneet
authors.initials: N
authors.lastname: Kaur
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Park
authors.forename: Yinglan
authors.initials: Y
authors.lastname: Jin
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Guncheol
authors.initials: G
authors.lastname: Kim
authors.forename: Ki Youn
authors.initials: KY
authors.lastname: Lee
authors.forename: Jee Sun
authors.initials: JS
authors.lastname: Yang
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Shin
authors.forename: Ky-Youb
authors.initials: KY
authors.lastname: Nam
authors.forename: Kyoung Tai
authors.initials: KT
authors.lastname: No
authors.forename: Gyoonhee
authors.initials: G
authors.lastname: Han
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D014508:Urea / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D014508:Urea; D019908:Proto-Oncogene Proteins c-raf