title: Quantification and classification of high-resolution magic angle spinning data for brain tumor diagnosis.
abstract: The goal of this work is to propose a complete protocol (preprocessing, processing and classification) for classifying brain tumors with proton high-resolution magic-angle spinning ((1)H HR-MAS) data. The different steps of the procedure are detailed and discussed. Feature extraction techniques such as peak integration, including also the automated quantitation method AQSES, were combined with linear (LDA) and non-linear (least-squares support vector machine or LS-SVM) classifiers. Classification accuracy was assessed using a stratified random sampling scheme. The results suggest that LS-SVM performs better than LDA while AQSES performs better than the standard peak integration feature extraction method.
authors.affiliation: Department of Electrical Engineering, SCD-SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Heverlee (Leuven), Belgium. jeanbaptiste.poullet@esat.kuleuven.be
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Poullet
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Martinez-Bisbal
authors.forename: Dani
authors.initials: D
authors.lastname: Valverde
authors.forename: Daniel
authors.initials: D
authors.lastname: Monleon
authors.forename: Bernardo
authors.initials: B
authors.lastname: Celda
authors.forename: Carles
authors.initials: C
authors.lastname: Arús
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D014408:Biomarkers, Tumor; D011522:Protons; D013113:Spin Labels