title: The "Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical evaluation of in silico oncology.
abstract: The "Oncosimulator" is at the same time a concept of multilevel integrative cancer and (treatment affected) normal tissue biology, an algorithmic construct and a software tool which aims at supporting the clinician in the process of optimizing cancer treatment on the patient individualized basis. Additionally it is a platform for better understanding and exploring the natural phenomenon of cancer as well as training doctors and interested patients alike. In order to achieve all of these goals it has to undergo a thorough clinical optimization and validation process. This is one of the goals of the European Commission funded integrated project "ACGT: Advancing Clinicogenomic Trials on Cancer". Nephroblastoma (Wilms' tumor) and breast cancer have been selected to serve as two paradigms to clinically specify and evaluate the "Oncosimulator" as well as the emerging domain of in silico oncology.
authors.affiliation: National Technical University of Athens, Institute of Communications and Computer Systems, Zografos, GR-157 80, Greece. gestam@central.ntua.gr
authors.forename: Georgios S
authors.initials: GS
authors.lastname: Stamatakos
authors.forename: Dimitra D
authors.initials: DD
authors.lastname: Dionysiou
authors.forename: Norbert M
authors.initials: NM
authors.lastname: Graf
authors.forename: Nikoletta A
authors.initials: NA
authors.lastname: Sofra
authors.forename: Christine
authors.initials: C
authors.lastname: Desmedt
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoppe
authors.forename: Nikolaos K
authors.initials: NK
authors.lastname: Uzunoglu
authors.forename: Manolis
authors.initials: M
authors.lastname: Tsiknakis
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D012984:Software; D014750:Vincristine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine