Vicinal amino alcohols as organocatalysts in asymmetric cross-aldol reaction of ketones: application in the synthesis of convolutamydine A.
Leucinol and valinol have been identified as efficient organocatalysts for the aldol reaction of isatin and its derivatives (as examples of activated, non-enolizable ketones) with acetone. Uncommon mechanistic features were observed and used in the formulation of the transition state of the reaction.
Malkov
Andrei V
AV
Department of Chemistry, Joseph Black Building, WestChem, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. amalkov@chem.gla.ac.uk
Kabeshov
Mikhail A
MA
Bella
Marco
M
Kysilka
Ondrej
O
Malyshev
Denis A
DA
Pluhácková
Kristýna
K
Kocovský
Pavel
P