CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Mottet
Christian
C
Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. christian.mottet@chuv.ch
Golshayan
Dela
D
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology; D060908:CTLA-4 Antigen; D051858:Forkhead Transcription Factors / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D016753:Interleukin-10 / Q000276:immunology / Q000502:physiology; D007376:Interleukin-2 / Q000276:immunology / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000502:physiology; D014181:Transplantation Immunology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D016212:Transforming Growth Factor beta; D016753:Interleukin-10