Silica-based mesoporous materials as drug delivery system for methotrexate release.
Antineoplastic methotrexate has been loaded through different soaking procedures on silica-based mesoporous materials and, successively, released mimicking an oral administration. The materials were prepared using a self-assembly mechanism in the presence of cationic surfactants with alkyl chain of 16, 12, and 10 carbon atoms in the synthesis mixture to obtain different pore diameter in the porous structure. Mesoporous materials were prepared as pure silica sample and in the presence of Al(OH)(3) in the synthesis mixture. Only alumina-silica samples were able to load methotrexate. The amounts of drug loaded and the in vitro release kinetics are a function of the pore size of the materials.
Carino
Ida Stefania
IS
Dipartimento di Ingegneria Chimica e dei Materiali, Università della Calabria, Rende, Italia.
Pasqua
Luigi
L
Testa
Flaviano
F
Aiello
Rosario
R
Puoci
Francesco
F
Iemma
Francesca
F
Picci
Nevio
N
D000536:Aluminum Hydroxide / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D009584:Nitrogen / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D017655:Silicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry; D014961:X-Ray Diffraction
D002593:Cetrimonium Compounds; D003692:Delayed-Action Preparations; C509968:MCM-41; D000644:Quaternary Ammonium Compounds; D017655:Silicon Compounds; D012972:Sodium Hydroxide; D000536:Aluminum Hydroxide; D012822:Silicon Dioxide; C022806:dodecyltrimethylammonium; D009584:Nitrogen; D008727:Methotrexate; D000077286:Cetrimonium