title: Profile of T cell immune responses in HIV-infected children from Uganda.
abstract: Human immunodeficiency virus (HIV) immunopathogenesis in children remains poorly understood. We assessed T cell immune activation in antiretroviral therapy-naive children in Uganda (n=154). Increased CD4+ and CD8+ T cell activation strongly correlated with decreased CD4+ T cell percentage. Interestingly, no correlation between plasma HIV RNA level and T cell activation was observed after controlling for CD4+ T cell count. In addition, the presence of Gag-specific CD4+ T helper responses was associated with increased HIV-specific CD8+ T cells. Understanding the balance between immune activation and T cell immunity in HIV-infected children may provide further insights into the mechanisms leading to effective immune control.
authors.affiliation: Joint Clinical Research Centre, Kampala, Uganda.
authors.forename: Isaac
authors.initials: I
authors.lastname: Ssewanyana
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elrefaei
authors.forename: Grant
authors.initials: G
authors.lastname: Dorsey
authors.forename: Theodore
authors.initials: T
authors.lastname: Ruel
authors.forename: Norman G
authors.initials: NG
authors.lastname: Jones
authors.forename: Anne
authors.initials: A
authors.lastname: Gasasira
authors.forename: Moses
authors.initials: M
authors.lastname: Kamya
authors.forename: Justine
authors.initials: J
authors.lastname: Nakiwala
authors.forename: Jane
authors.initials: J
authors.lastname: Achan
authors.forename: Edwin
authors.initials: E
authors.lastname: Charlebois
authors.forename: Diane
authors.initials: D
authors.lastname: Havlir
authors.forename: Huyen
authors.initials: H
authors.lastname: Cao
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000276:immunology; D052118:Lysosomal-Associated Membrane Protein 1 / Q000276:immunology; D052119:Lysosomal-Associated Membrane Protein 2 / Q000276:immunology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014454:Uganda
chemical_list: D052118:Lysosomal-Associated Membrane Protein 1; D052119:Lysosomal-Associated Membrane Protein 2; D007371:Interferon-gamma