title: Multivalent catalysts for the cleavage of nucleic acids and their models.
abstract: Multivalent systems, i.e. systems presenting a discrete collection of several functional groups, are well recognized for their ability to increase binding constants. Less explored is their use as catalysts. We present a number of multivalent nanostructures based on self-assembled gold nanoparticles and dendrimers, which are particularly efficient in the cleavage of nucleic acids and their models.
authors.affiliation: University of Padova, Department of Chemical Sciences, 35131-Padova, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Manea
authors.forename: Lucia
authors.initials: L
authors.lastname: Pasquato
authors.forename: Leonard J
authors.initials: LJ
authors.lastname: Prins
authors.forename: Paolo
authors.initials: P
authors.lastname: Scrimin
mesh_terms: D002384:Catalysis; D050091:Dendrimers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008956:Models, Chemical; D009708:Nucleotidases / Q000737:chemistry; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry*
chemical_list: C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D050091:Dendrimers; D010755:Organophosphates; D009943:Organophosphorus Compounds; D006046:Gold; D012260:Ribonucleases; D009708:Nucleotidases