title: Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues.
abstract: Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.
authors.affiliation: Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. naim@just.edu.jo
authors.forename: Naim H
authors.initials: NH
authors.lastname: Al-Said
authors.forename: Khaled Q
authors.initials: KQ
authors.lastname: Shawakfeh
authors.forename: Wasim N
authors.initials: WN
authors.lastname: Abdullah
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D000080890:Duocarmycins; D005609:Free Radicals / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D000080890:Duocarmycins; D005609:Free Radicals; D007211:Indoles; D011758:Pyrroles; D011804:Quinolines; C503382:indole-2-carboxylate; C410406:pyrroloquinoline; C066098:duocarmycin SA