Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model.
We compared the efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, in a rabbit model of methicillin-resistant Staphylococcus aureus-induced arthritis. Vancomycin, alone or in combination with rifampicin, and quinupristin/dalfopristin+rifampicin were significantly more effective than quinupristin/dalfopristin alone.
Hamel
Antoine
A
Université de Nantes, Nantes Atlantique Universités, Thérapeutiques cliniques et expérimentales des infections, EA 3826, UFR Médecine, 1 rue G. Veil, F-44000 Nantes, France.
Caillon
Jocelyne
J
Jacqueline
Cédric
C
Batard
Eric
E
Potel
Gilles
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001170:Arthritis, Infectious / Q000188:drug therapy*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D014640:Vancomycin / Q000494:pharmacology; D014769:Virginiamycin / Q000008:administration & dosage / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D014640:Vancomycin; D012293:Rifampin