Immunopathogenesis and role of T cells in psoriasis.
Psoriasis is a T cell-dependent autoimmune disease of the skin and joints. Disease manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing either interferon-gamma (Th1) or interleukin (IL)-17 (Th17). These Th1 and Th17 cells interact with dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an inflammation that mainly involves interferon-gamma, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19, and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL-12/IL-23 or deviate immune responses into a protective IL-4-dominated Th2 phenotype.
Ghoreschi
Kamran
K
Department of Dermatology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany. kamran.ghoreschi@med.uni-tuebingen.de
Weigert
Christina
C
Röcken
Martin
M
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D011565:Psoriasis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism
D016207:Cytokines