title: Dermoscopic changes in acral melanocytic nevi during digital follow-up.
abstract: OBJECTIVE
  To investigate changes in dermoscopic patterns of acquired acral melanocytic nevi (AAMN) over time.
  
  
  METHODS
  Retrospective analysis of digital dermoscopic follow-up of 230 AAMN located on acral volar skin.
  
  
  METHODS
  Outpatient clinics at university dermatology departments. Patients A total of 230 AAMN located on the soles (n = 149), fingers (n = 62), and palms (n = 19), of 230 white subjects 14 years or younger (n = 81), 15 to 30 years (n = 72), and older than 30 years (n = 77).
  
  
  METHODS
  Comparison of baseline and follow-up dermoscopic patterns.
  
  
  RESULTS
  Individual AAMN had a digital follow-up of 6 months (n = 59), 12 months (n = 74), 18 months (n = 44), and 24 months (n = 53). Baseline dermoscopic images showed the following patterns: parallel furrow (48.8%), latticelike (16.1%), fibrillar (10.9%), nontypical (10.9%), homogeneous (4.8%), globular (3.5%), transition (3.5%), and reticular (2.6%). Dermoscopic changes over time were observed in 42 of the 230 AAMN (18.3%), with the greatest frequency of changes occurring in patients 14 years or younger (23 of 81 lesions; 28.4%) (P = .005). The parallel furrow pattern (25.9%) showed more variations over time than other dermoscopic patterns (11.0%) (P = .004). The frequency of change increased linearly over time (P = .001). Four of 7 clinically regressing nevi showed a homogeneous pattern at the last examination.
  
  
  CONCLUSIONS
  Dermoscopic changes of AAMN are most common in subjects younger than 14 years. The parallel furrow pattern appears to be the dermoscopic pattern most subject to change, while the homogeneous pattern may be seen also in AAMN showing clinical and dermoscopic involution.
authors.affiliation: Department of Dermatology, University of L'Aquila, L'Aquila, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Altamura
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
authors.forename: Francesco
authors.initials: F
authors.lastname: Sera
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Fargnoli
authors.forename: Luigi
authors.initials: L
authors.lastname: Rossiello
authors.forename: Ketty
authors.initials: K
authors.lastname: Peris
mesh_terms: D000293:Adolescent; D000328:Adult; D046169:Dermoscopy; D003936:Diagnosis, Computer-Assisted; D005121:Extremities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery