Clathrin: an amazing multifunctional dreamcoat?
Internalization of cargo by clathrin-mediated endocytosis has been studied extensively. In this issue of Cell Host & Microbe, Cossart and colleagues report that a variety of pathogens induce the recruitment of clathrin and other endocytic proteins to sites of pathogen interaction with the cell surface. This recruitment is followed by actin rearrangements in the host cell necessary for the uptake or stable attachment of the pathogen at the cell surface.
Pauly
Barbara S
BS
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
Drubin
David G
DG
D000199:Actins / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D001424:Bacterial Infections / Q000382:microbiology*; D018407:Bacterial Physiological Phenomena; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000502:physiology*; D004705:Endocytosis; D006801:Humans
D000199:Actins; D002966:Clathrin