Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion.
D-Allose is one of the rare sugars produced from D-psicose. We examined whether d-allose reduces the extent of rat renal ischemia/reperfusion (I/R) injury by suppressing the activation of neutrophils. The renal concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and myeloperoxidase were significantly increased after renal I/R. These increases were significantly inhibited by D-allose administration. Furthermore, D-allose significantly inhibited the increase in the concentrations of blood urea nitrogen (BUN), creatinine, N-acetyl beta-D-glucosaminidase (NAG) and histopathologic changes after renal I/R. These findings strongly suggest that D-allose protects against I/R-induced renal injury by inhibiting the activation of neutrophils that play an important role in I/R-induced renal injury. These findings may have important implications in understanding the biologic functions of D-allose. D-Allose may prove useful in renal surgery and transplantation.
Ueki
Masaaki
M
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. mueki@med.kagawa-u.ac.jp
Taie
Satoshi
S
Chujo
Kousuke
K
Asaga
Takehiko
T
Iwanaga
Yasuyuki
Y
Maekawa
Nobuhiro
N
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D018375:Neutrophil Activation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology* / Q000517:prevention & control*
C002055:allose; D005947:Glucose