title: Major histocompatibility complex typing of dogs from Russia shows further dog leukocyte antigen diversity.
abstract: Blood samples from 85 Russian dogs and wolves were collected as dried blood spots on paper and transported to the UK by mail. We obtained partial or complete three-locus canine major histocompatibility complex [dog leukocyte antigen (DLA)] class II haplotypes on 81 of these samples. Six new alleles were identified: three DLA-DRB1 and three DLA-DQB1. These alleles occurred in haplotypic combinations not previously seen in other European dogs. One haplotype appeared to lack a DQB1 allele. Two of the new haplotypes segregated through a family of dogs that was investigated.
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. lorna.kennedy@manchester.ac.uk
authors.forename: L J
authors.initials: LJ
authors.lastname: Kennedy
authors.forename: J J
authors.initials: JJ
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Barnes
authors.forename: W E R
authors.initials: WE
authors.lastname: Ollier
authors.forename: S
authors.initials: S
authors.lastname: Knyazev
mesh_terms: D000483:Alleles; D000818:Animals; D004285:Dogs / Q000145:classification* / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D012426:Russia
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II