[A case of recurrent gastric cancer with peritoneal dissemination--prolonging life and good QOL by chemotherapy with combined use of paclitaxel].
A 55-year-old man with advanced gastric cancer underwent total gastrectomy (T3N0M0, stage II , por, sig) in the USA. Following his return to Japan, the patient then suffered from a recurrence with ileus, bilateral hydronephrosis and ascites caused by peritoneal dissemination. Systemic chemotherapy of paclitaxel combined with 5-FU was performed, and after four cycles, ileus, bilateral hydronephrosis and ascites disappeared. S-1 monotherapy was started to maintain his QOL, but after five cycles, ileus of the transverse colon recurred. Colostomy was performed and systemic chemotherapy of paclitaxel combined with S-1 was performed. For 13 months, the patient's condition remained stable and he returned to society, but died 30 months after the first recurrence. This case suggests that paclitaxel-based chemotherapy is a promising treatment for gastric cancer with peritoneal dissemination.
Hayashi
Yuko
Y
Dept. of Gastroenterology, International Medical Center of Japan.
Akiyama
Junichi
J
Watanabe
Mika
M
Nozaki
Yuichi
Y
Iwashita
Ryouko
R
Nagaoki
Yuko
Y
Sakurai
Toshiyuki
T
Oshima
Takao
T
Nagata
Naoyoshi
N
Yago
Yuzou
Y
Sako
Akahito
A
Kobayakawa
Masao
M
Tamegai
Yoshirou
Y
Masaki
Naohiko
N
Uemura
Naomi
N
Umeda
Noritsugu
N
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018394:CA-125 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011788:Quality of Life; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D017239:Paclitaxel; D005472:Fluorouracil