title: Chronic kidney disease increases risk for venous thromboembolism.
abstract: Chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease morbidity and mortality, but its association with incident venous thromboembolism (VTE) in non-dialysis-dependent patients has not been evaluated in a community-based population. With the use of data from the Longitudinal Investigation of Thromboembolism Etiology (LITE) study, 19,073 middle-aged and elderly adults were categorized on the basis of estimated GFR, and cystatin C (available in 4734 participants) was divided into quintiles. During a mean follow-up time of 11.8 yr, 413 participants developed VTE. Compared with participants with normal kidney function, relative risk for VTE was 1.28 (95% confidence interval [CI] 1.02 to 1.59) for those with mildly decreased kidney function and 2.09 (95% CI 1.47 to 2.96) for those with stage 3/4 CKD, when adjusted for age, gender, race, and center. After additional adjustment for cardiovascular disease risk factors, an increased risk for VTE was still observed in participants with stage 3/4 CKD, with a multivariable adjusted relative risk of 1.71 (95% CI 1.18 to 2.49). There was no significant association between cystatin C and VTE. In conclusion, middle-aged and elderly patients with CKD (stages 3 through 4) are at increased risk for incident VTE, suggesting that VTE prophylaxis may be particularly important in this population.
authors.affiliation: Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 S. 2nd Street, Minneapolis, MN 55454-1015, USA.
authors.forename: Keattiyoat
authors.initials: K
authors.lastname: Wattanakit
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
authors.forename: Catherine
authors.initials: C
authors.lastname: Stehman-Breen
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003928:Diabetic Nephropathies / Q000150:complications; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D005169:Factor VIII