A novel aromatic iodination method, with sodium periodate used as the only iodinating reagent.
Benzene, halobenzenes and some deactivated arenes readily reacted in anhydrous NaIO4/AcOH/Ac2O/concd. H2SO4 mixtures to afford, after quenching with excess aqueous Na2SO3 solution (a reducing agent), purified iodinated products in 27-88% yields. This novel method of aromatic iodination is simple, fairly effective and environmentally safe.
Luliński
Piotr
P
Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, Banacha 1, PL 02-097 Warsaw, Poland.
Sosnowski
Maciej
M
Skulski
Lech
L
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D007287:Inorganic Chemicals; D007455:Iodine; D009930:Organic Chemicals; D010504:Periodic Acid / Q000737:chemistry*
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D007287:Inorganic Chemicals; D009930:Organic Chemicals; D010504:Periodic Acid; D007455:Iodine; C009288:metaperiodate