title: Modulation of Bax expression in physiological and pathological human placentas throughout pregnancy.
abstract: Apoptosis is intimately involved in placental homeostasis, growth and remodelling, and apoptotic rates increase progressively during normal pregnancy as part of normal placental development. Moreover, apoptosis increases in pregnancies complicated by some pathologies such as preeclampsia, fetal growth restriction and diabetes. In the present study, we describe differences in the expression of proapoptotic protein Bax, in first trimester voluntary termination of pregnancy, first trimester abortion (reserved abortion), caesarean birth, spontaneous birth, preeclampsia and diabetes. We first observed a strong increase of Bax expression in the cytotrophoblast, stroma, endothelial cells and decidua of placentas of the first trimester abortion compared to the low/moderate Bax immunopositivity in all the placental compartments during the first trimester voluntary termination of pregnancy. Secondly, we showed a more intense immunopositivity for Bax in the third trimester spontaneous birth with respect to the third trimester caesarean birth. Thirdly, we observed an increase of Bax expression in preeclamptic placentas compared to the normal full-term placentas. In contrast, we observed a moderate Bax expression in diabetic placentas only slightly lower than the normal full-term placentas. Our results seem to suggest that deregulation of apoptotic turnover may lead to placental dysfunction and pathologies.
authors.affiliation: Department of Gynecology, Obstetric and Reproductive Science Section of Clinical Anatomy, Second University of Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Cobellis
authors.forename: Maria
authors.initials: M
authors.lastname: De Falco
authors.forename: Marco
authors.initials: M
authors.lastname: Torella
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Trabucco
authors.forename: Francesca
authors.initials: F
authors.lastname: Caprio
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Federico
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Manente
authors.forename: Gabriele
authors.initials: G
authors.lastname: Coppola
authors.forename: Vincenza
authors.initials: V
authors.lastname: Laforgia
authors.forename: Roberto
authors.initials: R
authors.lastname: Cassandro
authors.forename: Nicola
authors.initials: N
authors.lastname: Colacurci
authors.forename: Antonio
authors.initials: A
authors.lastname: De Luca
mesh_terms: D002585:Cesarean Section; D016640:Diabetes, Gestational / Q000378:metabolism / Q000473:pathology; D005260:Female; D006262:Health; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: C494826:BAX protein, human; D051028:bcl-2-Associated X Protein