Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxia.
The metabolic disorders associated with chronic hypoxemia in adult patients with tetralogy of Fallot (TOF) have not been fully appreciated. We report a 53-year-old male patient with TOF who presented with fasting hypoglycemia, hypertriglyceridemia, increased blood levels of free fatty acids, adiponectin, B-type natriuretic peptide, and uric acid. The cluster of these metabolic derangements has not been previously reported, and the possible role of chronic hypoxia in the production of these disturbances is discussed with a review of pertinent literatures.
Harada
Eisaku
E
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6-8-1 Yanamuro, Kumamoto City, Japan. eisaku-h@juryo.or.jp
Yasue
Hirofumi
H
Mizuno
Yuji
Y
Ito
Teruhiko
T
Sakaino
Naritsugu
N
Yasue
Shintarou
S
Masuzaki
Hiroaki
H
D052242:Adiponectin / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D015228:Hypertriglyceridemia / Q000378:metabolism; D007003:Hypoglycemia / Q000378:metabolism; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D013771:Tetralogy of Fallot / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*
D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D020097:Natriuretic Peptide, Brain