Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population.
OBJECTIVE
To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM).


METHODS
MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis.


RESULTS
Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls.


CONCLUSIONS
Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.
Tang
Li-Jiang
LJ
Department of Cardiology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang 317000, China. taizhoutang@hotmail.com
Chen
Xiao-Feng
XF
Zhu
Min
M
Jiang
Jian-Jun
JJ
Lu
Xian-Ben
XB
Du
Yu-Xi
YX
Wang
Bin
B
Fang
Chong-Feng
CF
Xue
Yin-Sheng
YS
Shen
Wei-Feng
WF
D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044382:Population Groups / Q000235:genetics; D012307:Risk Factors
C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1