title: Support vector machines as multivariate calibration model for prediction of blood glucose concentration using a new non-invasive optical method named Pulse Glucometry.
abstract: A novel optical non-invasive in vivo blood glucose concentration (BGL) measurement technique, named "Pulse Glucometry", was combined with a kernel method; support vector machines. The total transmitted radiation intensity (I lambda) and the cardiac-related pulsatile changes superimposed on I lambda in human adult fingertips were measured over the wavelength range from 900 to 1700 nm using a very fast spectrophotometer, obtaining a differential optical density (delta OD lambda) related to the blood component in the finger tissues. Subsequently, a calibration model using paired data of a family of delta OD lambda s and the corresponding known BGLs was constructed with support vector machines regression instead of using calibration by a conventional partial least squares regression (PLS). Our results show that the calibration model based on the support vector machines can provide a good regression for the 183 paired data, in which the BGLs ranged from 89.0-219 mg/dl (4.94-12.2 mmol/l). The resultant regression was evaluated by the Clarke error grid analysis and all data points fell within the clinically acceptable regions (region A: 93%, region B: 7%).
authors.affiliation: TYT Institute of Technology Corporation, 602 Famille Montagnus, 1-143 Morino-Sato, Kanazawa, 920-1167, JAPAN. m_ogawa@y5.dion.ne.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ogawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamakoshi
authors.forename: Makoto
authors.initials: M
authors.lastname: Satoh
authors.forename: Masamichi
authors.initials: M
authors.lastname: Nogawa
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamakoshi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tanaka
authors.forename: Peter
authors.initials: P
authors.lastname: Rolfe
authors.forename: Toshiyo
authors.initials: T
authors.lastname: Tamura
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Yamakoshi
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D002138:Calibration; D006801:Humans; D008962:Models, Theoretical; D008991:Monitoring, Physiologic / Q000379:methods*; D012984:Software; D013053:Spectrophotometry / Q000379:methods*
chemical_list: D001786:Blood Glucose