Rats in the genomic era.
The rat genome project and the resources that it has generated are transforming the translation of rat biology to human medicine. The rat genome was sequenced to a high quality "draft," the structure and location of the genes were predicted, and a global assessment was published (Gibbs RA et al., Nature 428: 493-521, 2004). Since that time, researchers have made use of the genome sequence and annotations and related resources. We take this opportunity to review the currently available rat genome resources and to discuss the progress and future plans for the rat genome.
Worley
K C
KC
Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. kworley@bcm.edu
Weinstock
G M
GM
Gibbs
R A
RA
D000818:Animals; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D005260:Female; D016678:Genome; D015698:Genomic Library; D023281:Genomics / Q000458:organization & administration; D006801:Humans; D051379:Mice; D054555:National Heart, Lung, and Blood Institute (U.S.); D054560:National Human Genome Research Institute (U.S.); D020641:Polymorphism, Single Nucleotide; D051381:Rats / Q000235:genetics*; D014481:United States