[Contrast enhanced power Doppler in evaluating the angiogenesis in hepatocellular carcinoma].
OBJECTIVE
To evaluate the role of contrast enhanced power Doppler in evaluating tumor angiogenetic activity.


METHODS
Thirty-two patients with hepatocellular carcinoma were analysed. Flow signals of hepatocellular carcinoma were observed by power Doppler imaging after the injection of contrast agent, and then the relative perfusion rate and blood flow were assessed. The microvessel density (MVD) and vascular endothelial growth factor(VEGF) were assessed by immunohistochemical method. The relationship between the relative perfusion rate,blood flow, MVD,VEGF was studied.


RESULTS
The relative perfusion rate in the tissues with positive expression of VEGF was significantly higher than that in the tissues with negative expression of VEGF in hepatocellular carcinoma. There was correlation between the relative perfusion rate, blood flow grade and MVD(P<0.05). The expression of VEGF was positively related to the relative perfusion rate and blood flow grade(P<0.05).


CONCLUSIONS
Contrast enhanced power Doppler is useful in evaluating the tumor angiogenetic activity.
Xiao
Ji-dong
JD
Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Shen
Shou-rong
SR
Li
Rui-zhen
RZ
Zhou
Ping
P
Zhu
Wen-hui
WH
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D018608:Ultrasonography, Doppler / Q000379:methods
D003287:Contrast Media