Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis.
Various clinical prognostic scoring systems (PSSs) have been suggested as means of selecting high-risk chronic idiopathic myelofibrosis (CIMF) patients at diagnosis. The WHO has recently proposed strict diagnostic criteria for CIMF, and the European consensus for bone marrow fibrosis (BMF) grading recommends 4 classes. It has been suggested that BMF grading may play a prognostic role in CIMF, but it has never been compared with the other PSSs in the same patients. We tested a prognostic model for overall survival (OS) based on the WHO criteria and BMF grading in 113 consecutive patients with chronic myeloproliferative disorders (98 with CIMF and 15 with postpolycythemic myelofibrosis), and compared the findings with those of PSSs. The results showed that our model is significantly associated with different OSs and, unlike the other PSSs, clearly discriminates the OS of intermediate- and high-risk patients.
Vener
Claudia
C
Ematologia I, Centro Trapianti di Midollo, University of Milan, Milano, Italy. claudiavener@tiscali.it
Fracchiolla
Nicola Stefano
NS
Gianelli
Umberto
U
Calori
Rossella
R
Radaelli
Franca
F
Iurlo
Alessandra
A
Caberlon
Sabrina
S
Gerli
Giancarla
G
Boiocchi
Leonardo
L
Deliliers
Giorgio Lambertenghi
GL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002908:Chronic Disease; D005060:Europe; D006454:Hemoglobins / Q000378:metabolism; D008679:Metaplasia / Q000473:pathology; D011086:Polycythemia / Q000145:classification / Q000473:pathology; D055728:Primary Myelofibrosis / Q000097:blood / Q000145:classification / Q000473:pathology; D011379:Prognosis; D003245:Consensus Statements as Topic
D006454:Hemoglobins