4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
Scipione
Luigi
L
Dipartimento di Studi di chimica e tecnologia delle sostanze biologicamente attive, Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Roma, Italia. luigi.scipione@uniroma1.it
De Vita
Daniela
D
Musella
Alessandra
A
Flammini
Lisa
L
Bertoni
Simona
S
Barocelli
Elisabetta
E
D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D015761:4-Aminopyridine; D012601:Scopolamine