Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation.
This retrospective cohort study aimed at determining whether overweight children undergoing allogeneic stem cell transplantation (SCT) had inferior overall survival compared with children who were not overweight. Children >/=2 years of age who received allogeneic SCT were included. Overweight was defined as a body mass index >/= 95th percentile; 54/325 (17%) children were overweight. Overall survival at 5 years was significantly inferior at 46.6 +/- 7.3% in the overweight group compared with 59.5 +/- 3.2% in the non-overweight group (P = 0.02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight.
Bulley
Sean
S
Division of Haematology/Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
Gassas
Adam
A
Dupuis
L Lee
LL
Aplenc
Richard
R
Beyene
Joseph
J
Greenberg
Mark L
ML
Doyle
John J
JJ
Sung
Lillian
L
D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008297:Male; D050177:Overweight / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome