Viral hepatitis B and C markers in the population of deceased donors in Poland.
In the years 2001 to 2005 in Poland, 3146 potential deceased donors were referred with 2583 (82%) organs procured and 57 (2%) donors not used due to positive viral markers. According to Polish rules, in every case of possible organ harvest from a deceased donor we test viral markers of anti-HIV I/II, HBsAg, and anti-HCV. Organs from HBsAg-positive donors (the rule accepted in Poland a few years ago) are not transplanted; kidneys from anti-HCV(+) donors are transplanted into matched recipients. According to donor hospital capabilities, other viral tests are performed: anti-HBs, anti-HBc, HBeAg, and anti-HBe. We calculate the frequency of positive serological tests for viral markers among the population of deceased donors, for HBsAg it was 1.1% (from these donors 10 kidneys and 1 liver were transplanted); and for anti-HCV it was 2.6% (from these donors 78 kidneys were used). Anti-HBc-positive deceased donors, particularly liver donors (due to the high risk of viral transmission and de novo infection), are a major problem in transplantation, which reduced the number of used organs. Only 17 of 86 (20%) of the HBc-positive donors became liver donors compared with 257 of 524 (49%) donors from the HBc-negative group. But anti-HBc was checked only in 24% of potential donors (positive in 16.6% of cases), which means that 506 of 780 transplanted livers (65%) were obtained from donors of unknown anti-HBc status, 257 (33%) from anti-HBc-negative subjects and 17 (2%) from anti-HBc-positive subjects.
Czerwiński
J
J
Polish Transplant Coordinating Centre Poltransplant, Warsaw, Poland. jczerwinski@poltransplant.pl
Malanowski
P
P
Wasiak
D
D
Pszenny
A
A
Gutowska
D
D
Kwiatkowski
A
A
Pacholczyk
A
A
Chmura
A
A
Małkowski
P
P
Wałaszewski
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D001344:Autopsy; D015415:Biomarkers / Q000032:analysis*; D006509:Hepatitis B / Q000175:diagnosis*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000175:diagnosis*; D006801:Humans; D018579:Patient Selection; D011044:Poland; D014019:Tissue Donors / Q000706:statistics & numerical data*
D015415:Biomarkers; D006514:Hepatitis B Surface Antigens