High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation.
Collapsin Response Mediator Protein (CRMP)-2 is involved in T-cell polarization and migration. To address the role of CRMP2 in neuroinflammation, we analyzed its involvement in lymphocyte recruitment to the central nervous system in mouse infected with neurotropic and non-neurotropic virus strains (RABV, CDV). A sub-population of early-activated CD69+CD3+ T lymphocytes highly expressing CRMP2 (CRMP2hi) peaked in the blood, lymph nodes and brain of mice infected with neurotropic viruses, and correlated with severity of disease. They displayed high migratory properties reduced by CRMP2 blocking antibody. These data point out the potential use of CRMP2 as a peripheral indicator of neuroinflammation.
Vuaillat
C
C
Inserm, U842, Lyon, F-69372 France.
Varrin-Doyer
M
M
Bernard
A
A
Sagardoy
I
I
Cavagna
S
S
Chounlamountri
I
I
Lafon
M
M
Giraudon
P
P
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001921:Brain / Q000276:immunology* / Q000473:pathology; D017252:CD3 Complex / Q000032:analysis; D002465:Cell Movement; D004216:Distemper / Q000276:immunology*; D018792:Encephalitis, Viral / Q000276:immunology* / Q000473:pathology; D005260:Female; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000502:physiology*; D037181:Lectins, C-Type; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000502:physiology*; D011818:Rabies / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000502:physiology*; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D036341:Intercellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins; D000099192:CD69 Antigens; C095114:collapsin response mediator protein-2