Connectivity analysis of EEG under drug therapy.
Analysis of human EEG constitutes a useful instrument for the evaluation of drug bioavailability at the brain. Linear and nonlinear techniques were applied to EEG signals for the assessment of brain connectivity after drug intake by coherence and cross mutual information, respectively. The main goal was to evaluate the pharmacological effect of different doses of alprazolam on the brain during wakefulness. Preliminary results reported in this work showed statistically significant differences in EEG channels coupling between the states corresponding to placebo and different drug doses. However, nonlinear variables correlated better with the expected within-doses and within-time effects.
Alonso
Joan F
JF
Biomedical Engineering Research Centre, Automatic Control Department, Technical University of Catalonia (UPC), Barcelona, Spain. joan.francesc.alonso@upc.edu
Mañanas
Miquel A
MA
Romero
Sergio
S
Riba
Jordi
J
Barbanoj
Manel J
MJ
Hoyer
Dirk
D
D000284:Administration, Oral; D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016903:Drug Monitoring / Q000379:methods*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D015990:Placebo Effect; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D006993:Hypnotics and Sedatives; D000525:Alprazolam