Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer.
The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible.
Nikishina
M V
MV
Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. mnikishina@rambler.ru
Vavilin
V A
VA
Makarova
S I
SI
Lyakhovich
V V
VV
D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D012800:Siberia; D012907:Smoking / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism; D044465:White People
D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human