title: Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer.
abstract: Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene. DMBT1/SAG/gp-340 belongs to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins, a superfamily of secreted or membrane-bound proteins with SRCR domains that are highly conserved down to sponges, the most ancient metazoa. On the one hand, DMBT1 may represent an innate defence factor acting as a pattern recognition molecule. It interacts with a broad range of pathogens, including cariogenic streptococci and Helicobacter pylori, influenza viruses and HIV, but also with mucosal defence proteins, such as IgA, surfactant proteins and MUC5B. Stimulation of alveolar macrophage migration, suppression of neutrophil oxidative burst and activation of the complement cascade point further to an important role in the regulation of inflammatory responses. On the other hand, DMBT1 has been demonstrated to play a role in epithelial and stem cell differentiation. Inactivation of the gene coding for this protein may lead to disturbed differentiation, possibly resulting in tumour formation. These data strongly point to a role for DMBT1 as a molecule linking innate immune processes with regenerative processes.
authors.affiliation: Department of Oral Biochemistry, Academic Centre for Dentistry, Free University, van de Boechorststraat 7, NL-1081 BT Amsterdam, The Netherlands. ajm.ligtenberg@vumc.nl
authors.forename: Antoon J M
authors.initials: AJ
authors.lastname: Ligtenberg
authors.forename: Enno C I
authors.initials: EC
authors.lastname: Veerman
authors.forename: Arie V
authors.initials: AV
authors.lastname: Nieuw Amerongen
authors.forename: Jan
authors.initials: J
authors.lastname: Mollenhauer
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics; D002135:Calcium-Binding Proteins; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins; D003731:Dental Caries / Q000235:genetics; D017353:Gene Deletion; D006031:Glycosylation; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007239:Infections / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D051116:Receptors, Scavenger / Q000235:genetics; D012038:Regeneration / Q000235:genetics / Q000502:physiology; D012463:Saliva / Q000502:physiology*; D025521:Tumor Suppressor Proteins; D015044:Zona Pellucida / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; C108174:DMBT1 protein, human; D004268:DNA-Binding Proteins; D011956:Receptors, Cell Surface; D051116:Receptors, Scavenger; D025521:Tumor Suppressor Proteins