title: Lower dopamine transporter density in an asymptomatic patient with Kleine-Levin syndrome.
abstract: BACKGROUND
  Kleine-Levin syndrome (KLS) is a rare disorder whose pathophysiological mechanisms remain unknown.
  
  
  METHODS
  To investigate dopamine abnormalities in KLS, a [99mTc]-TRODAT-1 single photon emission computerized tomography (SPECT) was performed in a patient with KLS during the asymptomatic period and compared with three matched healthy controls.
  
  
  RESULTS
  The patient had 14% lower striatal dopamine transporter binding potential (DAT-BP) compared to the mean DAT-BP of three healthy controls.
  
  
  CONCLUSIONS
  This study provides in vivo evidence for abnormalities in the DAT-BP, suggesting an involvement of the dopaminergic system in the pathophysiology of KLS.
authors.affiliation: LiNC-Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil. mqhoexter@psiquiatria.epm.br
authors.forename: M Q
authors.initials: MQ
authors.lastname: Hoexter
authors.forename: M C
authors.initials: MC
authors.lastname: Shih
authors.forename: D D
authors.initials: DD
authors.lastname: Mendes
authors.forename: C
authors.initials: C
authors.lastname: Godeiro-Junior
authors.forename: A C
authors.initials: AC
authors.lastname: Felicio
authors.forename: Y K
authors.initials: YK
authors.lastname: Fu
authors.forename: S
authors.initials: S
authors.lastname: Tufik
authors.forename: R A
authors.initials: RA
authors.lastname: Bressan
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D015609:Organotechnetium Compounds; D017286:Polysomnography / Q000379:methods; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1