Albright's hereditary osteodystrophy with extensive heterotopic ossification of the oral and maxillofacial region: how fetuin research may help a seemingly impossible condition.
Albright"s hereditary osteodystrophy (AHO) is a complex genetic disorder characterized by brachydactyly, gonadotropin resistance, hypothyroidism, pseudohypoparathyroid syndrome and heterotopic ossification. Heterotopic ossification rarely occurs in the maxillofacial region. In this article, we present such a case, describe the etiology, characteristics and treatment of AHO and suggest a potential role of an inhibitor of bone formation such as fetuin in preventing recurrence of aberrant ossification.
DuVal
Marc G
MG
Mount Sinai Hospital, Toronto, Ontario, Canada.
Davidson
Sarah
S
Ho
Andrew
A
Cohen
Rachale
R
Park
Michael
M
Nourian
Somayeh
S
Baker
Gerald
G
Sándor
George K B
GK
D000293:Adolescent; D000844:Ankylosis / Q000209:etiology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications*; D006801:Humans; D008297:Male; D008410:Masticatory Muscles / Q000503:physiopathology; D019767:Maxillofacial Abnormalities / Q000209:etiology*; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000517:prevention & control; D010012:Osteogenesis / Q000502:physiology; D011556:Pseudopseudohypoparathyroidism / Q000150:complications*; D013705:Temporomandibular Joint Disorders / Q000209:etiology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000502:physiology*
D019485:Bone Morphogenetic Proteins; D053773:Transforming Growth Factor beta1; D000509:alpha-Fetoproteins