Catheter-directed thrombolysis of inferior vena cava thrombosis in a 13-day-old neonate and review of literature.
Complete inferior vena cava thrombosis (IVC) in neonates is uncommon, but may cause significant morbidity. A 13-day-old neonate suffered IVC thrombosis secondary to antithrombin III deficiency, possibly contributed to by a mutation in the methyl tetrahydrofolate reductase gene. Catheter-directed thrombolysis (CDT) with recombinant tissue plasminogen activator (rt-PA, Alteplase) was used successfully to treat extensive venous thrombosis in this neonate without complications. We also review the literature on CDT for treatment of IVC thrombosis in critically ill neonates and infants.
Khan
Jawad U
JU
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Takemoto
Clifford M
CM
Casella
James F
JF
Streiff
Michael B
MB
Nwankwo
Ikechi J
IJ
Kim
Hyun S
HS
D000058:Accidental Falls; D002406:Catheterization, Peripheral; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D015912:Thrombolytic Therapy / Q000379:methods*; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*