title: [Preparation of gemcitabine polybutylcyanoacrylate nanoparticles].
abstract: OBJECTIVE
  To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).
  
  
  METHODS
  According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.
  
  
  RESULTS
  The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.
  
  
  CONCLUSIONS
  An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.
authors.affiliation: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hls83@fimmu.com
authors.forename: Le-song
authors.initials: LS
authors.lastname: Huang
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Wang
authors.forename: Zhi-liang
authors.initials: ZL
authors.lastname: Chen
authors.forename: Jia
authors.initials: J
authors.lastname: Wan
authors.forename: Xi-qing
authors.initials: XQ
authors.lastname: Yan
authors.forename: Gang
authors.initials: G
authors.lastname: Duan
mesh_terms: D002626:Chemistry, Pharmaceutical; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D016503:Drug Delivery Systems; D004659:Enbucrilate / Q000138:chemical synthesis*; D053758:Nanoparticles / Q000737:chemistry*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D004659:Enbucrilate; D000093542:Gemcitabine