The pathomechanism of degenerative changes in joints.
Osteoarthritis is a slowly progressive degeneration of articular surfaces, leading to the disruption of the chondral layers of the joint. Modern diagnostic and laboratory techniques make it possible to investigate the mechanism underlying the changes taking place in osteoarthritis and the role of the molecular substances involved in this disease, i.e. matrix metalloproteinases, cytokines and growth factors. The pathomechanism of changes leading to osteochondral disruption of the joint in osteoarthritis are discussed In the present study.
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Katedra i Klinika Ortopedii i Traumatologii Narzadu Ruchu, Akademia Medyczna, Warszawa; Zakład Chirurgii Doświadczalnej i Transplantacyjnej, CMDiK PAN, Warszawa.