[Interleukin-17 in chronic inflammatory and autoimmune diseases: rheumatoid arthritis, Crohn's disease and Wegener's granulomatosis].
Data from recent animal experiments and clinical studies show that interleukin-17 (IL-17A, B, C, D, E, and F) plays an important role as proinflammatory cytokine in the host response to extracellular bacteria and in chronic inflammatory and autoimmune diseases. These findings have led to a revision of the well-known T(H)1/T(H)2 hypothesis. In rheumatoid arthritis elevated IL-17 serum levels, Th-17 cells in synovial fluid and in T-cell-rich areas of inflamed synovia are found. In Wegener's granulomatosis, IL-17D is expressed in nasal granulomas. In Crohn's disease IL-17 as well as IL-17 plus IFN-gamma producing CD4(+) T-cells are detected in peripheral blood and inflamed intestinal mucosa. So far, CD4(+)IL-17(+)IFN-gamma(+) T-cells have been described only in humans. These and other findings indicate a number of differences in the cytokine response between murine models and human beings.
Müller
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Poliklinik für Rheumatologie, Vaskulitiszentrum UKSH und Rheumaklinik Bad Bramstedt, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. mueller@mail.uni-luebeck.de
Lamprecht
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P
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D018448:Models, Immunological
D020381:Interleukin-17