Bactericidal antibiotics and oxidative stress: a radical proposal.
A recent publication suggests that many antibiotics exert their bactericidal effects via the production of hydroxyl radicals, regardless of their molecular targets. This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests.
Hassett
Daniel J
DJ
Department of Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45221, USA. daniel.hassett@uc.edu, jimlay@uiuc.edu
Imlay
James A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017665:Hydroxyl Radical; D018384:Oxidative Stress / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D017665:Hydroxyl Radical