Ischemic cholangiopathy after liver transplantation from controlled non-heart-beating donors-a single-center experience.
BACKGROUND
Previous reports have shown that livers from controlled non-heart-beating-donors (NHBD) are associated with higher rates of primary failure and ischemic cholangiopathy of orthotopic liver transplantation (OLT) as a complication of the prolonged warm ischemia.


METHODS
This retrospective review of activities from 1999 to 2006 examined donor characteristics of age, liver function tests, warm ischemic time before (1WITa) and after cardiac arrest (1WITb), cold ischemic time (CIT) and transplant results.


RESULTS
Eleven NHBD retrieved livers were transplanted from "ideal" donors except for one elderly donor (73 years). Of the 11 recipients, 3 developed biliary cholangiopathy (27%). There were no episodes of primary graft nonfunction, but one recipient displayed primary graft dysfunction. Two recipients died: one due to biliary complications with sepsis (long CIT >10 hours, fatty liver), and the other due to aspiration pneumonia and hypoxic brain damage with normal liver function. One recipient required retransplantation owing to ischemic cholangiopathy (1WITb 45 min) at 6 months after OLT with a good result. The other eight recipients are alive (observation period 72 to 14 months) including six with normal liver function, one with biopsy-proven biliary ischemia and one with recurrent primary sclerosing cholangitis without biliary ischemic changes on biopsy. Among 164 heart-beating donors recipients transplanted in the same period, biliary complications occurred in 27 patients (16%), of whom 12 were leaks and 15 anastomotic strictures.


CONCLUSIONS
NHBD were a good source for livers with reasonable early results. To avoid late complications especially ischemic cholangiopathy, caution is urged with the use of these organs as well as strict donor and ischemic time criteria.
Kaczmarek
B
B
Liver Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom. kaczbart@poczta.onet.pl
Manas
M D
MD
Jaques
B C
BC
Talbot
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D001926:Brain Death; D002761:Cholangitis / Q000209:etiology*; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome