title: Antifungal amides from Piper scutifolium and Piper hoffmanseggianum.
abstract: Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A ( 1) and scutifoliamide B ( 2), together with the known compounds piperolactam C ( 3), piperovatine ( 4), piperlonguminine ( 5), corcovadine ( 6), isopiperlonguminine ( 7), and isocorcovadine ( 8). From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmannseggiamide A ( 9) and hoffmannseggiamide B ( 10), were obtained together with the known compounds isopiperlonguminine ( 7) and isocorcovadine ( 8), sitosterol, and stigmasterol. The structures of the new compounds were established on the basis of spectroscopic data analysis. The inhibitory activity of compounds 1-10 against the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides was determined by bioautography.
authors.affiliation: Instituto de Química, Universidade de São Paulo, CP 26077, 05513-970, São Paulo, SP, Brazil.
authors.forename: Joaquim V
authors.initials: JV
authors.lastname: Marques
authors.forename: Rodrigo O Saga
authors.initials: RO
authors.lastname: Kitamura
authors.forename: João Henrique G
authors.initials: JH
authors.lastname: Lago
authors.forename: Maria Claudia M
authors.initials: MC
authors.lastname: Young
authors.forename: Elsie F
authors.initials: EF
authors.lastname: Guimarães
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002963:Cladosporium / Q000187:drug effects*; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000577:Amides; D000935:Antifungal Agents; D052117:Benzodioxoles; C527029:scutifoliamide A; C527030:scutifoliamide B