Molecular diversity of Dscam: recognition of molecular identity in neuronal wiring.
Our understanding of how the enormously complex task of interconnecting millions of nerve cells is accomplished remains rudimentary. What molecular mechanisms control its exquisite specificity? Can we pinpoint single molecular interactions that might help to explain some of the specificity requirements that underlie neuronal wiring? A series of recent studies on the molecular diversity of the Drosophila melanogaster cell-surface receptor Down syndrome cell-adhesion molecule (Dscam) provide one exceptional example of a novel mechanistic model of neuronal-wiring specificity, progressing from structural studies of single protein-protein interactions to biochemical analysis in vitro and to an understanding of complex neuronal differentiation at the single-cell or tissue levels.
Schmucker
Dietmar
D
Department of Neurobiology, Harvard Medical School, and at the Dana-Faber Cancer Institute, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA. dietmar_schmucker@dfci.harvard.edu
D000818:Animals; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004331:Drosophila melanogaster; D006801:Humans; D009415:Nerve Net / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C491736:Dscam1 protein, Drosophila; D019006:Neural Cell Adhesion Molecules