Selank and its metabolites maintain homeostasis in the gastric mucosa.
Antiulcer properties of a synthetic anxiolytic Selank and in vivo formed metabolites of this compound were studied on 3 experimental models of ulceration. The test peptides decreased the area of experimental gastric ulcers.
Pavlov
T S
TS
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Samonina
G E
GE
Bakaeva
Z V
ZV
Zolotarev
Yu A
YA
Guseva
A A
AA
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006706:Homeostasis; D008297:Male; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications
D000897:Anti-Ulcer Agents; D009842:Oligopeptides; D000431:Ethanol; D019342:Acetic Acid; C100827:TP 7