title: Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model.
abstract: We compared the efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, in a rabbit model of methicillin-resistant Staphylococcus aureus-induced arthritis. Vancomycin, alone or in combination with rifampicin, and quinupristin/dalfopristin+rifampicin were significantly more effective than quinupristin/dalfopristin alone.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, Thérapeutiques cliniques et expérimentales des infections, EA 3826, UFR Médecine, 1 rue G. Veil, F-44000 Nantes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Hamel
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Caillon
authors.forename: Cédric
authors.initials: C
authors.lastname: Jacqueline
authors.forename: Eric
authors.initials: E
authors.lastname: Batard
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001170:Arthritis, Infectious / Q000188:drug therapy*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D014640:Vancomycin / Q000494:pharmacology; D014769:Virginiamycin / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D014640:Vancomycin; D012293:Rifampin