title: Patterning of polymer nanofiber meshes by electrospinning for biomedical applications.
abstract: The end-product of the electrospinning process is typically a randomly aligned fiber mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the collector. The developed electric field causes the stretching of the fibers and their random deposition. By judicious selection of the collector architecture, it is thus possible to develop other morphologies on the nanofiber meshes. The aim of this work is to prepare fiber meshes using various patterned collectors with specific dimensions and designs and to evaluate how those patterns can affect the properties of the meshes relevant to biomedical applications. This study aims at verifying whether it is possible to control the architecture of the fiber meshes by tailoring the geometry of the collector. Three different metallic collector topographies are used to test this hypothesis. Electrospun nonwoven patterned meshes of polyethylene oxide (PEO) and poly( -caprolactone) (PCL) were successfully prepared. Those fiber meshes were analyzed by scanning electron microscopy (SEM). Both mechanical properties of the meshes and cell contacting experiments were performed to test the effect of the produced patterns over the properties of the meshes relevant for biomedical applications. The present study will evaluate cell adhesion sensitivity to the patterns generated and the effect of those patterns on the tensile properties of the fiber meshes.
authors.affiliation: Department of Polymer Engineering, University of Minho, Campus de Azurem, 4800-058 Guimarães, Portugal. nuno@dep.uminho.pt
authors.forename: Nuno M
authors.initials: NM
authors.lastname: Neves
authors.forename: Rui
authors.initials: R
authors.lastname: Campos
authors.forename: Adriano
authors.initials: A
authors.lastname: Pedro
authors.forename: José
authors.initials: J
authors.lastname: Cunha
authors.forename: Francisco
authors.initials: F
authors.lastname: Macedo
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004563:Electrochemistry / Q000379:methods; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012399:Rotation; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D046911:Macromolecular Substances; D011091:Polyesters; C405621:poly(epsilon-caprolactone-co-ethylene oxide); D011092:Polyethylene Glycols