title: Multicomponent approach to the synthesis of oxidized amides through nitrile hydrozirconation.
abstract: "Oxidized" amides, as represented by acyl aminals and acyl hemiaminals, are integral subunits of several natural products that exhibit useful biological activity. In this paper a multicomponent approach to these groups from acylimine intermediates is demonstrated. The acylimines are accessed through a sequence of nitrile hydrozirconation and acylation, making this highly versatile amide synthesis useful for a range of applications in target- and diversity-oriented synthesis.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Shuangyi
authors.initials: S
authors.lastname: Wan
authors.forename: Michael E
authors.initials: ME
authors.lastname: Green
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Paul E
authors.initials: PE
authors.lastname: Floreancig
mesh_terms: D000577:Amides / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010084:Oxidation-Reduction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000577:Amides; D009570:Nitriles; D015040:Zirconium