A concise organocatalytic and enantioselective synthesis of isotetronic acids.
A concise enantioselective route to isotetronic acids using an organocatalyzed aldol reaction between alpha-oxocarboxylic acids and aldehydes has been developed, leading to the titled compounds in reasonable yields and good enantioselectivities.
Vincent
Jean-Marc
JM
University Bordeaux-1, CNRS-UMR 5255, Institut des Sciences Moléculaires, 351, cours de la libération, 33405 Talence, France. jm.vincent@ism.u-bordeaux1.fr
Margottin
Chrystèle
C
Berlande
Muriel
M
Cavagnat
Dominique
D
Buffeteau
Thierry
T
Landais
Yannick
Y
D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D002942:Circular Dichroism; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D005663:Furans; C038235:bromoacetaldehyde; C116609:3-hydroxybutanal; D000079:Acetaldehyde; C003422:tetronic acid