title: Multiple regioselective functionalizations of quinolines via magnesiations.
abstract: A wide range of polyfunctionalized quinolines was prepared via chemo- and regioselective magnesiation reactions using appropriate Mg reagents, such as i-PrMgCl.LiCl, MesMgBr.LiCl, Mes2Mg.2LiBr, TMPMgCl.LiCl, and TMP2Mg.2LiCl. An application to the total synthesis of the biologically active compound talnetant was performed (six steps, 28%).
authors.affiliation: Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
authors.forename: Nadège
authors.initials: N
authors.lastname: Boudet
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Lachs
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D008274:Magnesium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011804:Quinolines; D008274:Magnesium