Studies on the antimicrobial potential of the cardiovascular drug lacidipine.
The cardiovascular drug lacidipine was screened in vitro for possible antibacterial activity with respect to 389 Gram-positive and Gram-negative bacterial strains. It was noticed that most bacteria (233) failed to grow at 50-200 microg/mL concentrations of the drug. Some strains were inhibited at even lower concentrations. The bacteria could be arranged according to their decreasing order of sensitivity as follows: Staphylococcus aureus, Vibrio cholerae, Salmonella spp., Shigellae, Escherichia coli, Bacillus spp., Klebsiellae and Pseudomonas spp. Lacidipine was found to be bacteriostatic in nature against S. aureus and V cholerae. When administered to Swiss strain of white mice at doses of 30 and 60 microg/mouse, lacidipine significantly protected the animals challenged with 50 MLD of S. typhimurium NCTC 74. According to the chi-square test, the in vivo data were highly significant (p<0.001).
Dasgupta
Asish
A
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
Jeyaseeli
L
L
Dutta
Noton Kumar
NK
Mazumdar
Kaushiki
K
Karak
Prithviraj
P
Dastidar
Sujata G
SG
Motohashi
Noboru
N
Shirataki
Yoshiaki
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004095:Dihydropyridines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008297:Male; D051379:Mice; D015394:Molecular Structure; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology; D018675:Toxicity Tests
D000900:Anti-Bacterial Agents; D002317:Cardiovascular Agents; D004095:Dihydropyridines; C060285:lacidipine