Clickable 2'-O-alkyladenosine building blocks.
An efficient and selective synthesis of 2'-O-alkyl modified adenosine nucleosides carrying either a triple bond function or an azido group is reported. These nucleosides are thus armed for performing 1,3 dipolar cycloadditions (click chemistry)(1). Derivatives suitable for further conversion into different building blocks are reported.
Wenska
Malgorzata
M
Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
Milton
Stefan
S
Strömberg
Roger
R
D000227:Adenine Nucleotides / Q000737:chemistry; D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry
D000227:Adenine Nucleotides; D009841:Oligonucleotides; D000241:Adenosine