title: Rats with different profiles of impulsive choice behavior exhibit differences in responses to caffeine and d-amphetamine and in medial prefrontal cortex 5-HT utilization.
abstract: This study investigated if sub-populations of rats characterized by their basal level of impulsivity (BLI) in a delayed-reinforcement task, displayed differences in the functioning of neurotransmitter systems modulating impulsive choice behavior. For this, the effects of various doses of caffeine and d-amphetamine were investigated in three sub-populations of rats displaying pronounced differences in their impulsive choice behavior and their post-mortem serotonergic and dopaminergic functions were assessed. Caffeine and d-amphetamine reduce impulsive choice behavior only in the Medium BLI sub-population. Dopamine utilization was similar in the three sub-populations, but serotonin utilization was lower in the prefrontal cortex of the Medium and Very high BLI sub-populations as compared to the low BLI one. These results suggest that anti-impulsive effects of caffeine and d-amphetamine are dependent on the BLI of rats and that a low serotonergic function in the prefrontal cortex may be a trait marker of impulsivity evaluated by impulsive choice behavior.
authors.affiliation: Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7191, ULP/CNRS, IFR 37 de Neurosciences, Strasbourg, France. alexandra.barbelivien@linc.u-strasbg.fr
authors.forename: Alexandra
authors.initials: A
authors.lastname: Barbelivien
authors.forename: Erwan
authors.initials: E
authors.lastname: Billy
authors.forename: Christine
authors.initials: C
authors.lastname: Lazarus
authors.forename: Christian
authors.initials: C
authors.lastname: Kelche
authors.forename: Monique
authors.initials: M
authors.lastname: Majchrzak
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000378:metabolism; D007266:Inhibition, Psychological; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D012201:Reward; D012701:Serotonin / Q000378:metabolism; D018709:Statistics, Nonparametric
chemical_list: D000697:Central Nervous System Stimulants; D012701:Serotonin; D002110:Caffeine; D006897:Hydroxyindoleacetic Acid; D003913:Dextroamphetamine; D004298:Dopamine