title: Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.
abstract: An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.
authors.affiliation: Institut für Organische Chemie, Universität zu Köln, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lanver
authors.forename: Hans-Günther
authors.initials: HG
authors.lastname: Schmalz
mesh_terms: D000586:Amination / Q000528:radiation effects; D002625:Chemistry, Organic / Q000379:methods; D017606:Chlorine Compounds / Q000737:chemistry / Q000528:radiation effects; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis; D008872:Microwaves; D008954:Models, Biological; D009705:Nucleosides / Q000138:chemical synthesis*; D011687:Purines / Q000737:chemistry / Q000528:radiation effects*
chemical_list: D017606:Chlorine Compounds; D006839:Hydrocarbons, Acyclic; D009705:Nucleosides; D011687:Purines; C079308:6-chloropurine