title: The lipin protein family: dual roles in lipid biosynthesis and gene expression.
abstract: The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 alpha and PPAR alpha. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States. reuek@ucla.edu
authors.forename: Karen
authors.initials: K
authors.lastname: Reue
authors.forename: Peixiang
authors.initials: P
authors.lastname: Zhang
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D010711:Phosphatidate Phosphatase / Q000378:metabolism; D010766:Phosphorylation; D014158:Transcription, Genetic
chemical_list: D008055:Lipids; D009687:Nuclear Proteins; C485999:LPIN1 protein, human; D010711:Phosphatidate Phosphatase