Synthesis and evaluation of 2-pyrrolepolyamide-2'-deoxyguanosine 5'-phosphate.
2-Pyrrolepolyamide-2'-deoxyguanosine 5'-phosphate (hybrid 4) was synthesized and evaluated in terms of the inhibition of mouse mammary carcinoma FM3A cell growth. Hybrid 4 exhibited the highest activity compared with the other hybrids (1, 2, and 3) and distamycin A.
Kawashima
Etsuko
E
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji,Tokyo 192-0392, Japan. kawasima@ps.toyaku.ac.jp
Nakanishi
Yasuhiro
Y
Terui
Yusuke
Y
Tomitori
Hideyuki
H
Kashiwagi
Keiko
K
Ohba
Yusuke
Y
Kamaike
Kazuo
K
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
C528369:2-pyrrolepolyamide-2'-deoxyguaonsine 5'-phosphate; D000970:Antineoplastic Agents; D011758:Pyrroles; D006157:Guanosine Monophosphate