Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection.
Prostaglandins are known to be produced by macrophages when challenged with Trypanosoma cruzi, the etiological agent of Chagas' disease. It is not known whether these lipid mediators play a role in oxidative stress in host defenses against this important protozoan parasite. In this study, we demonstrated that inducible cyclooxygenase-mediated prostaglandin production is a key chemical mediator in the control of parasite burden and erythrocyte oxidative stress during T. cruzi infection in C57BL/6 and BALB/c mice, prototype hosts for the study of resistance and susceptibility in murine Chagas' disease. The results suggested the existence of at least two mechanisms of oxidative stress, dependent or independent with regard to the nitric oxide and cyclooxygenase pathway, where one or the other is more evident depending on the mouse strain.
Hideko Tatakihara
Vera L
VL
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Paraná, Brazil.
Cecchini
Rubens
R
Borges
Celso L
CL
Malvezi
Aparecida D
AD
Graça-de Souza
Viviane K
VK
Yamada-Ogatta
Sueli F
SF
Rizzo
Luiz V
LV
Pinge-Filho
Phileno
P
D000740:Anemia / Q000469:parasitology*; D000818:Animals; D001769:Blood / Q000469:parasitology; D001772:Blood Cell Count; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008264:Macrophages / Q000737:chemistry / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000032:analysis; D018384:Oxidative Stress / Q000276:immunology*; D011453:Prostaglandins / Q000276:immunology / Q000378:metabolism; D016019:Survival Analysis; D014349:Trypanosoma cruzi / Q000276:immunology* / Q000302:isolation & purification
D016861:Cyclooxygenase Inhibitors; D006454:Hemoglobins; D011453:Prostaglandins; D009569:Nitric Oxide