Clinical significance of the metabolic syndrome in the absence of established hypertension and diabetes: A community-based study.
OBJECTIVE
Our aim was to determine the predictive values on the all-cause and cardiovascular mortality and the future risks of hypertension and diabetes of the metabolic syndrome defined by the third report of the National Cholesterol Education Program's Adult Treatment Panel in the absence of established hypertension and diabetes (who may still have elevated blood pressure within 130-139/85-89mmHg and/or elevated fasting blood glucose within 5.5-6.9mmol/L (100-125mg/dL)).


METHODS
A community-based population of 11,058 Chinese aged 30 years and above in Kinmen island was followed up for 10.6 years. All-cause and cardiovascular mortality and incidence of hypertension and diabetes mellitus were determined.


RESULTS
The hazard ratios and 95% confidence intervals for all-cause and cardiovascular mortality in subjects with metabolic syndrome but without hypertension and diabetes versus subjects without metabolic syndrome, hypertension, and diabetes, were 0.81 (0.51-1.30) and 0.89 (0.57-1.37) in men, and 1.14 (0.45-2.92) and 0.73 (0.27-2.68) in women, respectively. In the non-diabetic non-hypertensives at baseline, the odds ratios and 95% confidence intervals for predicting hypertension and diabetes for subjects with versus without the metabolic syndrome were 2.25 (1.80-2.82) and 3.12 (2.30-4.24), respectively.


CONCLUSIONS
In this Chinese population, metabolic syndrome in the absence of hypertension and diabetes was not associated with increased risk of all-cause or cardiovascular mortality. In contrast, the presence of metabolic syndrome predicted future risk of hypertension and diabetes. Therefore, the intervention strategies for subjects with metabolic syndrome may be focused on the prevention of hypertension and diabetes.
Hsu
Pai-Feng
PF
Department of Health I-Lan Hospital, I-Lan, Taiwan.
Chuang
Shao-Yuan
SY
Cheng
Hao-Min
HM
Tsai
Shih-Tzer
ST
Chou
Pesus
P
Chen
Chen-Huan
CH
D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood; D016001:Confidence Intervals; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000208:ethnology; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D013624:Taiwan / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides