Folding pathways of human telomeric hybrid G-quadruplex structure.
The human telomeric DNA sequence d[AGGG(TTAGGG)(3)] forms the G-quadruplex structure. The G-quadruplex structure has become an attractive target for the anticancer drugs, because it effectively inhibits telomerase activity. Recently, the human telomere G-quadruplex in K(+) solution has been determined as a hybrid of mixed parallel and antiparallel structures. In this study, we investigated the folding pathway of human telomeric hybrid G-quadruplex structure.
Mashimo
Tomoko
T
Department of Chemistry, Graduate Schoool of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
Sugiyama
Hiroshi
H
D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D016615:Telomere / Q000737:chemistry*
D004247:DNA