title: Effects of recombinant IL-4delta2 on human peripheral blood mononuclears.
abstract: In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4delta2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4delta2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
authors.affiliation: Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: A N
authors.initials: AN
authors.lastname: Silkov
authors.forename: V A
authors.initials: VA
authors.lastname: Gavrilenko
authors.forename: V V
authors.initials: VV
authors.lastname: Denisova
authors.forename: L V
authors.initials: LV
authors.lastname: Grishina
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
authors.forename: S V
authors.initials: SV
authors.lastname: Sennikov
mesh_terms: D017398:Alternative Splicing; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000235:genetics / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: C508598:IL4 protein, human; D015850:Interleukin-6; D011994:Recombinant Proteins; D015847:Interleukin-4; D007073:Immunoglobulin E