Mesangiolytic glomerulopathy after radiotherapy and chemotherapy of gastric lymphoma.
Mesangiolytic glomerulopathy is an uncommon complication of irradiation and chemotherapy of THP-COP [pirarubicin, cyclophosphamide (CPA), vincristin (VCR), predonisolone (PSL)] and CHOP (CPA, Doxorubicin, VCR, PSL). We report a case of 63-year-old man 7 months status post radiation, and 10 months post chemotherapy for gastric lymphoma. The patient showed proteinuria and mild renal insufficiency. Renal biopsy revealed marked mesangiolysis in the glomeruli without any immune depositions. After the administration of angiotensin II receptor blocker, the patient's renal function remained stable for over two years. Mesangiolysis was thought to be a characteristic glomerular lesion in this patient treated with both chemoagents and radiation.
Yoshimura
Junko
J
Division of Nephrology, Kurume University School of Medicine. ymjunko@med.kurume-u.ac.jp
Kato
Seiya
S
Tamaki
Kiyoshi
K
Kohno
Keisuke
K
Kaneyuki
Utako
U
Maeda
Mitsuhide
M
Saikusa-Itoh
Yuiko
Y
Hayashida
Ayako
A
Iida
Shuji
S
Suefuji
Hiroaki
H
Okuda
Seiya
S
D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D019808:Losartan / Q000627:therapeutic use; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D047228:Angiotensin II Type 1 Receptor Blockers; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D019808:Losartan; D011241:Prednisone