title: Induction of mild hypothermia in cardiac arrest survivors presenting with cardiogenic shock syndrome.
abstract: BACKGROUND
  Induction of mild hypothermia (MH) in patients resuscitated from cardiac arrest improves their outcome. However, benefits and risks of MH in patients who remain in cardiogenic shock after the return of spontaneous circulation (ROSC) are unclear. We analysed all cardiac arrest survivors who were treated with MH in our intensive coronary care unit (CCU) and compared the outcome of patients with cardiogenic shock syndrome (CSS) with those who were circulatory stable.
  
  
  METHODS
  We performed retrospective analysis of all consecutive cardiac arrest survivors treated by MH in our CCU from November 2002 to August 2006. They were classified into two groups, according to whether they met the criteria for cardiogenic shock or not before MH initiation.
  
  
  RESULTS
  Out of 56 consecutive patients, 28 fulfilled criteria of cardiogenic shock before MH initiation (group A) and 28 were relatively stable (group B). In-hospital mortality was 57.1% in group A and 21.4% in group B patients (P=0.013). Favourable neurological outcome anytime during hospitalization was found in 67.9% of group A patients and in 82.1% of group B subjects (P=0.355). Favourable discharge neurological outcome was reached in 39.3% in group A and in 71.4% in group B (P=0.031). The complication rate in both groups did not differ.
  
  
  CONCLUSIONS
  While in-hospital mortality in cardiac arrest survivors treated by MH was expectably higher in those with cardiogenic shock than in stable patients, the favourable neurological outcome during hospitalization was comparable in both groups. Therefore, induction of MH should be considered in cardiac arrest survivors with CSS after ROSC.
authors.affiliation: II Department of Internal Cardiovascular Medicine, General Teaching Hospital, Prague 2, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Skulec
authors.forename: T
authors.initials: T
authors.lastname: Kovarnik
authors.forename: G
authors.initials: G
authors.lastname: Dostalova
authors.forename: J
authors.initials: J
authors.lastname: Kolar
authors.forename: A
authors.initials: A
authors.lastname: Linhart
mesh_terms: D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D003325:Coronary Care Units; D018153:Czech Republic; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000401:mortality / Q000628:therapy*; D006339:Heart Rate; D017052:Hospital Mortality; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D016017:Odds Ratio; D010043:Outcome and Process Assessment, Health Care; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000150:complications* / Q000175:diagnosis; D016019:Survival Analysis; D013577:Syndrome; D016896:Treatment Outcome