title: Likelihood of having isolated postchallenge hyperglycemia in an Iranian urban population.
abstract: To identify subjects who would most likely benefit from oral glucose tolerance test (OGTT) for diagnosis of diabetes mellitus (DM), namely isolated postchallenge hyperglycemia (IPH) (i.e. FPG<126mg/dl and 2h-PG>or=200mg/dl), we evaluated data and results of OGTT of 9745 participants of Tehran Lipid and Glucose Study (TLGS), aged >20 years and without previously diagnosed DM. The overall prevalence of IPH was 3.1% (95% CI: 2.8-3.4%, n=302). In the multivariate logistic regression analysis, the odds ratios (OR) for IPH were statistically significant for FPG>or=100mg/dl (OR 9.5; 95% CI: 7.1-12.5), age >or=40 years (OR 2.6; 95% CI: 1.8-3.7), triglycerides >or=200mg/dl (OR 2.1; 95% CI: 1.6-2.7), hypertension (OR 2.0; 95% CI: 1.5-2.6) and abnormal waist circumference (OR 1.9; 95% CI: 1.3-2.8). In subjects with FPG<126mg/dl, findings that best distinguished between IPH and non-diabetic subjects were FPG>or=100mg/dl [positive likelihood ratio (LR(+))=5.2], FPG>or=100mg/dl together with triglycerides >or=200mg/dl [LR(+)=9.7] and a combination of all the five factors [LR(+)=12.9]. This analysis showed that in Iranian urban subjects with FPG<126mg/dl, factors such as FPG>or=100mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were the best predictors of presence of IPH; OGTT would hence be recommended for opportunistic screening of IPH in subjects with above mentioned characteristics.
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. fhospanah@erc.ac.ir
authors.forename: Farhad
authors.initials: F
authors.lastname: Hosseinpanah
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rambod
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006973:Hypertension / Q000097:blood / Q000150:complications; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications; D007492:Iran; D016013:Likelihood Functions; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D014504:Urban Health / Q000706:statistics & numerical data*; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose