title: AFM study of a new carrier based on PLA and salen copolymers for gene therapy.
abstract: The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
authors.affiliation: Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, (Québec), Canada.
authors.forename: Véronique
authors.initials: V
authors.lastname: Nadeau
authors.forename: Patrice
authors.initials: P
authors.lastname: Hildgen
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D005029:Ethylenediamines / Q000737:chemistry*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis
chemical_list: D004337:Drug Carriers; D005029:Ethylenediamines; D011091:Polyesters; D011108:Polymers; D012545:Schiff Bases; D019344:Lactic Acid; C033616:poly(lactide); C011452:disalicylaldehyde ethylenediamine