Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.
An approach was developed for the synthesis of 5'-branched neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinyl-stannane system of the key synthetic intermediate (14) in the present study, was prepared by radical-mediated sulfur-extrusive stannylation.
Kumamoto
Hiroki
H
School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. kumamoto@pharm.showa-u.ac.jp
Tanaka
Hiromichi
H
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry
C528352:5'-(tributyltin)-2',3'-O-isopropylidene-4'-trityladenosine; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D005609:Free Radicals; D009947:Organotin Compounds; D013455:Sulfur; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine