Roles of HMGA proteins in cancer.
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely, unrearranged HMGA overexpression is a feature of malignant tumours and is also causally related to neoplastic cell transformation. Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins.
Fusco
Alfredo
A
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli "Federico II", via Pansini, 5, 80131, Naples, Italy. afusco@napoli.com
Fedele
Monica
M
D000236:Adenoma / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation; D004195:Disease Models, Animal; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D024003:HMGA Proteins / Q000235:genetics / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes; D010641:Phenotype; D010911:Pituitary Neoplasms / Q000235:genetics / Q000378:metabolism
D024003:HMGA Proteins