title: Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population.
abstract: OBJECTIVE
  To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM).
  
  
  METHODS
  MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis.
  
  
  RESULTS
  Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls.
  
  
  CONCLUSIONS
  Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.
authors.affiliation: Department of Cardiology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang 317000, China. taizhoutang@hotmail.com
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Tang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Jiang
authors.forename: Xian-Ben
authors.initials: XB
authors.lastname: Lu
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Du
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Chong-Feng
authors.initials: CF
authors.lastname: Fang
authors.forename: Yin-Sheng
authors.initials: YS
authors.lastname: Xue
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044382:Population Groups / Q000235:genetics; D012307:Risk Factors
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1