Transcription factors as therapeutic targets in lymphoid malignancies.
Aberrant activation of transcription factors is frequently observed in lymphoid malignancies. Chromosomal abnormalities, genetic mutations, and/or activation of upstream molecules induce ectopic activation of transcription factors, which can remodel intracellular states by deregulating gene expression. A number of studies have shown that aberrant activity of transcription factors plays a crucial role in oncogenesis. Recent reports on specific inhibitors suggest that transcription factors could be feasible therapeutic targets. In this review, I describe the implications of transcription factors in oncogenesis as well as novel therapeutic approaches based on our previous findings including nuclear factor-kappaB inhibitor, synthetic retinoid, and histone deacetylase inhibitor.
Sanda
Takaomi
T
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. tsanda@med.nagoya-cu.ac.jp
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D051881:Receptor, Notch1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D012176:Retinoids / Q000378:metabolism / Q000627:therapeutic use; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D016328:NF-kappa B; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; D012176:Retinoids; D014157:Transcription Factors; D053829:Amyloid Precursor Protein Secretases; D006655:Histone Deacetylases