[Specificity of activity antioxidative enzymes at protein deficiency and excessive content Cu, Zn, Mn, Se in the food].
The research of kinetic properties (Km u Vmax) of two enzymes: Superoxide Dismutase and Glutathione Peroxidase from rats liver and blood and lipid peroxidation induced by both a low protein diet (8%) and 2-fold concentration Cu, Zn, Mn, Se in diet. There was a change of Km and Vmax: the reduction of Km(GPH) was in liver at 28 d and the increase of Km(SOD) was in liver in group with 2-fold concentration Cu, Zn, Mn, Se in diet. The analysis of Km and Vmax of Superoxide Dismutase and Glutathione Peroxidase in different alimentary influence may be as one of methods for assessment individualization of diet therapy.
Ivakhnenko
V I
VI
Mal'tsev
G Iu
GIu
Vasil'ev
A V
AV
Gmoshinskiĭ
I V
IV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003300:Copper / Q000008:administration & dosage; D004035:Diet Therapy / Q000379:methods; D004044:Dietary Proteins / Q000008:administration & dosage; D019587:Dietary Supplements; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D012643:Selenium / Q000008:administration & dosage; D013482:Superoxide Dismutase / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage
D000975:Antioxidants; D004044:Dietary Proteins; D008345:Manganese; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D015032:Zinc