title: Interferon alpha induces a good molecular response in a patient with chronic eosinophilic leukemia (CEL) carrying the JAK2V617F point mutation.
abstract: The JAK2 V617F point mutation is very rare in hypereosinophilic syndrome and/or chronic eosinophilic leukemia. Here we report on a patient with chronic eosinophilic leukemia and detectable JAK2 mutant clone, who achieved a good molecular response to interferon alpha-2a after 4 months of treatment. The molecular response correlated with only moderate haematological improvement.
authors.affiliation: Departament of Haematology and Bone Marrow Transplantation, Silesian Medical University, 40-027 Katowice, Dabrowski str. 25, Poland. ghelbig@o2.pl
authors.forename: G
authors.initials: G
authors.lastname: Helbig
authors.forename: B
authors.initials: B
authors.lastname: Stella-Holowiecka
authors.forename: M
authors.initials: M
authors.lastname: Majewski
authors.forename: M
authors.initials: M
authors.lastname: Lewandowska
authors.forename: J
authors.initials: J
authors.lastname: Holowiecki
mesh_terms: D002908:Chronic Disease; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy* / Q000235:genetics; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D011994:Recombinant Proteins; D016896:Treatment Outcome
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D053614:Janus Kinase 2