title: Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage.
abstract: Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O(2)(-) release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-kappaB pathway-related genes.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: G
authors.initials: G
authors.lastname: Chamilos
authors.forename: R E
authors.initials: RE
authors.lastname: Lewis
authors.forename: G
authors.initials: G
authors.lastname: Lamaris
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: D P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D001232:Aspergillus fumigatus / Q000254:growth & development / Q000276:immunology; D006801:Humans; D025301:Hyphae / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D018384:Oxidative Stress; D012233:Rhizopus / Q000254:growth & development / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D000099181:Dectin-1
chemical_list: D037181:Lectins, C-Type; D008565:Membrane Proteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D013481:Superoxides; D051195:Toll-Like Receptor 2; D000099181:Dectin-1