title: Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
abstract: Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding transcription factor activated by multiple cytokines and interferons. High expression of STAT3 has also been implicated in cancer and lymphoma. Here, we show a case of B cell lymphoma in which a defective human immunodeficiency virus 1 (HIV-1) integrated upstream of the first STAT3 coding exon. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma. The provirus had a 5' long terminal repeat (LTR) deletion, but the 3' LTR had stronger promoter activity than the STAT3 promoter in reporter assays. Immunohistochemistry showed increased expression of STAT3 in the nuclei of lymphoma cells. Transfection of STAT3 resulted in transient cell proliferation in primary B cells in vitro. Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case.
authors.affiliation: Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. katano@nih.go.jp
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sato
authors.forename: Satomi
authors.initials: S
authors.lastname: Hoshino
authors.forename: Natsuo
authors.initials: N
authors.lastname: Tachikawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Morishita
authors.forename: Takaomi
authors.initials: T
authors.lastname: Ishida
authors.forename: Toshiki
authors.initials: T
authors.lastname: Watanabe
authors.forename: William N
authors.initials: WN
authors.lastname: Rom
authors.forename: Shigeo
authors.initials: S
authors.lastname: Mori
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiden
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hoshino
mesh_terms: D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics* / Q000378:metabolism*; D016662:Virus Integration
chemical_list: D004279:DNA, Viral; D050796:STAT3 Transcription Factor