RNA Pol IV plays catch with Argonaute 4.
Small-interfering RNAs regulate gene expression by affecting chromatin structure, transcription, translation, and RNA stability. In a recent report in Genes & Development, El-Shami et al. (2007) show that in plants, Argonaute 4-which is involved in RNA-directed DNA methylation-directly associates with RNA polymerase IVb through a repeat motif, establishing an intimate molecular link between RNAi and transcription.
Till
Susanne
S
EMBL International PhD Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Ladurner
Andreas G
AG
D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D060565:Argonaute Proteins; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012313:RNA / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D014158:Transcription, Genetic
C471209:AGO4 protein, Arabidopsis; D029681:Arabidopsis Proteins; D060565:Argonaute Proteins; D034741:RNA, Small Interfering; D012313:RNA; C499181:RNA polymerase IV, Arabidopsis; D012321:DNA-Directed RNA Polymerases