Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline.
A case of osteomyelitis caused by multidrug-resistant Pseudomonas aeruginosa is reported in a patient who underwent allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. The patient was successfully treated by prolonged administration of a full dose of colistin and tigecycline, and surgical curettage with the positioning of resorbable calcium sulfate pellets loaded with colistin.
Stanzani
Marta
M
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Tumietto
Fabio
F
Division of Infectious Diseases, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Giannini
Maria Benedetta
MB
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Bianchi
Giuseppe
G
Rizzoli Orthopaedic Institutes, 5th Division, University of Bologna, Italy.
Nanetti
Anna
A
Department of Clinical and Experimental Medicine, Section of Microbiology S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Vianelli
Nicola
N
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Arpinati
Mario
M
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Giovannini
Maddalena
M
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Bonifazi
Francesca
F
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Bandini
Giuseppe
G
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Baccarani
Michele
M
Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003091:Colistin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D000078304:Tigecycline; D014184:Transplantation, Homologous
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline; D003091:Colistin