title: Hepatic arterial infusion of chemotherapy: the role of diagnostic and interventional radiology.
abstract: Hepatic arterial infusion of chemotherapy (HAIC) delivers higher local drug concentration to unresectable liver tumors with fewer significant systemic side-effects. It has been shown to produce better response rates than systemic chemotherapy and remains an important treatment option in patients with advanced, inoperable primary or metastatic hepatic tumors. Traditionally, catheters for HAIC were inserted surgically under general anesthesia. The advancement and expansion of interventional radiology have made it possible for catheter-port systems to be inserted percutaneously under local anesthesia with no significant increase in morbidity. A comprehensive review of the literature, techniques and complications of percutaneous placement of catheter-port systems for HAIC is presented in this article.
authors.affiliation: Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Ganeshan
authors.forename: S
authors.initials: S
authors.lastname: Upponi
authors.forename: Lye-quen
authors.initials: LQ
authors.lastname: Hon
authors.forename: D
authors.initials: D
authors.lastname: Warakaulle
authors.forename: R
authors.initials: R
authors.lastname: Uberoi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002404:Catheterization / Q000379:methods; D002408:Catheters, Indwelling; D002544:Cerebral Infarction / Q000209:etiology / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000473:pathology; D005548:Foreign-Body Migration / Q000209:etiology / Q000517:prevention & control; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D015641:Radiography, Interventional
chemical_list: D000970:Antineoplastic Agents