[The molecular mechanism of signal transduction of neurotrophins and apoptosis of neurocyte].
Apoptosis is a programmed process of cellular death. The neurocyte apoptosis plays an important role in the growth, development, differentiation and maturity of nerve system during the embryonic period, in the brain damage caused by various reasons, and in the occurrence of nerve degenerative diseases. Neurotrophins (NTS) can initiate the cascade activation of related messenger molecules through the activation of corrersponding target cell membrane receptors, and thus delay the apoptosis of neurocytes, facilitate its survival, and bring its biological function into full play. The research of the molecular mechanism of family signal transduction of NTS and apoptosis of neurocytes will assist in the early intervention and treatment of nerve developmental handicap, brain damage and nerve degenerative diseases with different causes.
Luo
Xiaoli
X
West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Mao
Meng
M
D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009414:Nerve Growth Factors / Q000502:physiology*; D009420:Nervous System / Q000166:cytology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D009414:Nerve Growth Factors; D019253:Proto-Oncogene Proteins c-bcl-2; D020928:Mitogen-Activated Protein Kinases; D020169:Caspases