Functionalization of 6-nitrobenzo[1,3]dioxole with carbonyl compounds via TDAE methodology.
We report herein the synthesis of substituted 2-(6-nitrobenzo[1,3]dioxol-5-yl)-1- aryl ethanols and 2-(6-nitrobenzo[1,3]dioxol-5-yl)-propionic acid ethyl esters from the reaction of 5-chloromethyl-6-nitrobenzo[1,3]dioxole with various aromatic carbonyl and alpha- carbonyl ester derivatives using the tetrakis(dimethylamino)ethylene (TDAE) methodology.
Amiri-Attou
Ouassila
O
Laboratoire de Chimie Organique Pharmaceutique, CNRS-UMR 6517, Faculté de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cx 5, France.
Terme
Thierry
T
Vanelle
Patrice
P
D052117:Benzodioxoles / Q000737:chemistry*; D003642:Deanol / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009579:Nitrobenzoates / Q000737:chemistry*
D052117:Benzodioxoles; D007202:Indicators and Reagents; D009579:Nitrobenzoates; D003642:Deanol