title: Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications.
abstract: Curcumin, the primary active ingredient in the spice turmeric, was converted to reactive monofunctional derivatives (carboxylic acid/azide/alkyne). The derivatives were employed to produce a 3 + 2 azide-alkyne "clicked" curcumin dimer and a poly(amidoamine) (PAMAM) dendrimer-curcumin conjugate. The monofunctional curcumin derivatives retain biological activity and are efficient for labeling and dissolving amyloid fibrils. The curcumin dimer selectively destroys human neurotumor cells. The synthetic methodology developed affords a general strategy for attaching curcumin to various macromolecular scaffolds.
authors.affiliation: Department of Chemistry, City University of New York at the College of Staten Island, 2800 Victory Boulevard, Staten Island, New York 10314, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Sukanta
authors.initials: S
authors.lastname: Dolai
authors.forename: Samar
authors.initials: S
authors.lastname: Rizk
authors.forename: Afshan
authors.initials: A
authors.lastname: Hussain
authors.forename: Hussnain
authors.initials: H
authors.lastname: Tariq
authors.forename: Saadyah
authors.initials: S
authors.lastname: Averick
authors.forename: William
authors.initials: W
authors.lastname: L'Amoreaux
authors.forename: Abdeslem
authors.initials: A
authors.lastname: El ldrissi
authors.forename: Probal
authors.initials: P
authors.lastname: Banerjee
authors.forename: Krishnaswami
authors.initials: K
authors.lastname: Raja
mesh_terms: D003474:Curcumin / Q000737:chemistry*; D050091:Dendrimers; D019281:Dimerization; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011073:Polyamines / Q000737:chemistry*
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D003474:Curcumin