title: Versatile preparation of fluorescent particles based on polyphosphazenes: from micro- to nanoscale.
abstract: A series of intrinsically fluorescent hydrophobic and amphiphilic polyphosphazenes with ethyl tryptophan (EtTrp) and poly(N-isopropylacrylamide) (PNIPAAm) or poly(ethylene glycol) (PEG) as hydrophobic and hydrophilic segments, respectively, are synthesized. Depending on polymer composition and preparation procedure, particles with diameters ranging from micro- to nanoscale can be prepared successfully, which might be used as a visible tracer, both in vitro or in vivo, in drug- or gene-delivery systems, as well as in other biomedical studies such as diagnostic medicine and brain research. Most importantly, in combination with the flexible synthesis and versatile modification of polyphosphazene, this method provides a general protocol to engineer a broad range of fluorescent particles with different properties based on diverse polymers.
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Institute of Polymer Science, Zhejiang University, Hangzhou 310027, PR China. jxzhang1980@gmail.com
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Liyan
authors.initials: L
authors.lastname: Qiu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
authors.forename: Kangjie
authors.initials: K
authors.lastname: Zhu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D045744:Cell Line, Tumor; D005453:Fluorescence; D006801:Humans; D008823:Micelles; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D012996:Solutions; D014364:Tryptophan / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D008823:Micelles; D009943:Organophosphorus Compounds; D011108:Polymers; D012996:Solutions; C108974:poly(phosphazene); C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D014364:Tryptophan