title: Anterior mediastinal tumors: diagnostic accuracy of CT and MRI.
abstract: OBJECTIVE
  To compare the diagnostic accuracy for anterior mediastinal tumors among CT, MRI, and both CT and MRI, and to determine the optimal CT and MRI procedures for the diagnosis of anterior mediastinal tumors.
  
  
  METHODS
  Both CT and MRI were performed in 127 patients with pathologically diagnosed anterior mediastinal tumors. The patients included 48 cases of thymoma, 12 cases of thymic carcinoma, 12 cases of thymic cyst, 20 cases of mature teratoma, 13 cases of malignant germ cell tumor, and 22 cases of malignant lymphoma. The CT and MRI scans were assessed by two chest radiologists without knowledge of their clinical and pathologic data. The observers recorded various CT and MRI findings and their first choice of diagnosis.
  
  
  RESULTS
  The two observers made a correct first-choice diagnosis in an average of 78 (61%) of 127 cases on CT, 71 (56%) of 127 cases on MRI, and 85.5 (67%) of 127 cases on both CT and MRI. These included 83% cases of thymoma on CT, 84% on MRI, and 85% on both CT and MRI; 38% cases of thymic carcinoma on CT and 13% on MRI, and 33% on both CT and MRI; 46% cases of thymic cyst on CT and 71% on MRI, and 63% on both CT and MRI; 58% cases of mature teratoma and 38% on MRI, and 78% on both CT and MRI; 35% cases of malignant germ cell tumor on CT and 27% on MRI, and 31% on both CT and MRI; and 55% cases of malignant lymphoma on CT and 43% on MRI, and 61% on both CT and MRI. There were significant differences between the diagnostic accuracy by CT and MRI in the cases with both thymic cysts and thymic carcinoma (p<0.05).
  
  
  CONCLUSIONS
  CT is equal or superior to MRI in the diagnosis of anterior mediastinal tumors except for thymic cyst. CT should be considered the modality of choice following chest radiography, however, in certain circumstances, such as thymic cyst with hemorrhage or inflammation which mimic solid tumor despite low enhancement, MRI may be better in distinguishing anterior mediastinal tumors. For more helpful information in the diagnosis of mature teratoma after CT, MRI may follow.
authors.affiliation: Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. tomiyama@radiol.med.osaka-u.ac.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Honda
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Tsubamoto
authors.forename: Atsuo
authors.initials: A
authors.lastname: Inoue
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Sumikawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Kuriyama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kusumoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult