Cellular response to low adhesion nanotopographies.
This review focuses on how cells respond to low-adhesion nanotopographies. In order to do this, fabrication techniques, how cells may locate nanofeatures through the use of filopodia and possible mechanotransductive mechanisms are discussed. From this, examples of low-adhesion topographies and sizes and arrangements that may lead to low-adhesion are discussed. Finally, it is hypothesized as to how specifically low-adhesion materials may fit into the outlined mechanotransductive mechanisms.
Dalby
Matthew J
MJ
Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UK. m.dalby@bio.gla.ac.uk
D001672:Biocompatible Materials / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D018929:Cell Culture Techniques / Q000379:methods*; D049329:Nanostructures / Q000008:administration & dosage* / Q000648:ultrastructure*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials