Sequential copper-catalyzed vinylation/cyclization: an efficient synthesis of functionalized oxazoles.
A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
Martín
Rubén
R
Department of Chemistry, Massachusetts Instituteof Technology, Cambridge, Massachusetts 02139, USA.
Cuenca
Ana
A
Buchwald
Stephen L
SL
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D010080:Oxazoles; D003300:Copper