[Effects of 5F from Pteris semipinnate L on growth of human pathological scars in nude mice].
OBJECTIVE
To investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.


METHODS
5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.


RESULTS
Administration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.


CONCLUSIONS
5F could effectively inhibit the growth of pathological scars in nude mice.
Zhang
Yun-song
YS
Department of Plastic Surgery, Guangzhou Red Cross Hospital, Southern Medical University, Guangzhou 510220, China. yszhang5201314@163.com
He
Jing-hua
JH
Luo
Shao-jun
SJ
Li
Ye-yang
YY
Liang
Min
M
D000818:Animals; D002921:Cicatrix / Q000188:drug therapy* / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010936:Plant Extracts / Q000627:therapeutic use; D032495:Pteris / Q000737:chemistry*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
D024042:Collagen Type I; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D053773:Transforming Growth Factor beta1