Copper(II) complexes with ligands derived from 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: synthesis and biological activity.
The synthesis of Cu(II) complexes derived from Schiff base ligands obtained by the condensation of 2-hydroxybenzaldehyde or terephtalic aldehyde with 4-amino-antipyrine (4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) is presented. The newly prepared compounds were characterized by( 1)H-NMR, UV-VIS, IR and ESR spectroscopy. The determination of the antimicrobial activity of the ligands and of the complexes was carried out on samples of Escherichia coli, Klebsiella pneumoniae, Acinetobacter boumanii, Pseudomonas aeruginosa, Staphylococcus aureus and Candida sp. The qualitative and quantitative antimicrobial activity test results proved that all the prepared complexes are very active, especially against samples of Ps. aeruginosa, A. Boumanii, E. coli and S. aureus.
Rosu
Tudor
T
Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, 050107, Romania. rosu.tudor@unibuc.ro
Pasculescu
Simona
S
Lazar
Veronica
V
Chifiriuc
Carmen
C
Cernat
Raluca
R
D000632:Aminopyrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004055:Differential Thermal Analysis; D004058:Diffusion; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry
D000900:Anti-Bacterial Agents; D008024:Ligands; D000632:Aminopyrine; C017444:isopyrin; D003300:Copper