[Enhancement of angiogenesis as the basis of reparative morphogenesis in ischemic myocardial lesion].
The formation of new blood vessels is essential for the reparation of ischemic tissue. Animal model studies of myocardial ischemia showed that cell transplantation, gene therapy, and application of growth factors are able to promote collateral circulation development. Subsequent clinical trials conducted with these methods used for treatment of coronary artery disease demonstrated the safety and clinical benefits of this novel therapeutic approach called therapeutic angiogenesis. This method of treatment of ischemic lesions associated with cardiovascular diseases opens new clinical options in the area of tissue regeneration.
Potapov
I V
IV
Kirillov
I A
IA
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D016026:Bone Marrow Transplantation; D017690:Cell Transplantation; D002478:Cells, Cultured; D003097:Collateral Circulation; D003327:Coronary Disease / Q000628:therapy; D004195:Disease Models, Animal; D004285:Dogs; D016228:Endothelial Growth Factors / Q000627:therapeutic use; D015316:Genetic Therapy; D006321:Heart / Q000502:physiology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000637:transplantation*; D018919:Neovascularization, Physiologic; D010641:Phenotype; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D012038:Regeneration; D013552:Swine; D013997:Time Factors
D043925:Angiogenesis Inducing Agents; D016228:Endothelial Growth Factors