Synthesis, reactivity and biological activity of novel bisbenzofuran-2-yl-methanone derivatives.
Preparation of bisbenzofuran-2-yl-methanone (1), the corresponding ketoxime 4, semicarbazone and thiosemicarbazone 3a and 3b, ether derivatives of the ketoximes 5a-j and the alcohol 2 are described. These substances have been prepared in excellent yields. All the synthesized compounds except 5i have been tested against five different microorganisms and some of them were found to be active against some of the species studied.
Kirilmis
Cumhur
C
Department of Chemistry, Faculty of Arts and Sciences, Firat University, 23119 Elazig, Turkey.
Koca
Murat
M
Cukurovali
Alaaddin
A
Ahmedzade
Misir
M
Kazaz
Cavit
C
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D001572:Benzofurans