Chemical and photochemical synthesis of substituted dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c']diquinolin-6,14-dione.
Some new substituted dihydrothieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones 9- 12 and tetrahydrodithieno[2,3-b: 2',3'-d]thieno[2'',3''-c:2'',3''-c']diquinolin-6,14-dione (17) were prepared from the corresponding new anilides 5-8 and from the corresponding dianilide 15, respectively, by a multistep combination of chemical and photochemical reactions. All the prepared compounds are of particular interest because they might serve as DNA intercalators in anticancer therapy.
Safarik
Jelena Blazević
JB
Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia.
Koruznjak
Jasna Dogan
JD
Karminski-Zamola
Grace
G
D000813:Anilides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008954:Models, Biological; D055601:Organic Chemistry Phenomena; D010777:Photochemistry; D015363:Quinolones / Q000138:chemical synthesis*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
D000813:Anilides; D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D015363:Quinolones; D013876:Thiophenes; C526019:tetrahydrodithieno(2,3-b-2',3'-d)thieno(2'',3''c-2'',3''c')diquinolin-6,14-dione