title: The synthesis of dicationic extended bis-benzimidazoles.
abstract: The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.
authors.affiliation: Department of Chemistry Georgia State University, Atlanta, Georgia 30303, USA.
authors.forename: Zhijan
authors.initials: Z
authors.lastname: Kang
authors.forename: Christine C
authors.initials: CC
authors.lastname: Dykstra
authors.forename: David W
authors.initials: DW
authors.lastname: Boykin
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010419:Pentamidine / Q000737:chemistry
chemical_list: D000475:Alkenes; D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D003521:Cyclopropanes; D009570:Nitriles; C526760:trans-1,2-bis(4-cyanophenyl)cyclopropane; C526759:trans-1,2-bis(4-cyanophenyl)ethene; C009712:bis-benzimidazole; D010419:Pentamidine