title: Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the effect of metformin pretreatment on in vitro maturation (IVM) in the patients with clomiphene citrate-resistant polycystic ovary syndrome.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  University affiliated hospital.
  
  
  METHODS
  Fifty-six women with clomiphene citrate-resistant polycystic ovary syndrome underwent 70 cycles of IVM treatment.
  
  
  METHODS
  Metformin was administered at a dose of 500 mg twice per day for 12 weeks before IVM treatment.
  
  
  METHODS
  The number of immature oocytes, oocyte maturation, fertilization, cleavage, high-quality embryo, and clinical pregnancy rates.
  
  
  RESULTS
  A significantly higher high-quality embryo rate (37.8%) was obtained in the metformin-treated group compared with the control group (24.3%). Accordingly, the clinical pregnancy and implantation rates were significantly higher in the metformin-treated group (38.2% and 15.3%) than the control group (16.7% and 6.2%).
  
  
  CONCLUSIONS
  Pretreatment with metformin improves IVM outcome in terms of embryo quality and clinical pregnancy rate as well as implantation rate.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China.
authors.forename: Zhaolian
authors.initials: Z
authors.lastname: Wei
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.forename: Lin
authors.initials: L
authors.lastname: Cong
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000150:complications / Q000188:drug therapy*; D008687:Metformin / Q000008:administration & dosage*; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011292:Premedication / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin