Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.
Kong
G
G
Wang
D
D
Wang
H
H
Wu
J
J
Bielawski
J
J
Konopleva
M
M
Andreeff
M
M
Ruvolo
P P
PP
Maurer
B J
BJ
D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D002518:Ceramides / Q000096:biosynthesis*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D017313:Fenretinide / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014407:Tumor Cells, Cultured
C472829:1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole; C116817:2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; D002518:Ceramides; D007093:Imidazoles; D017382:Reactive Oxygen Species; D017313:Fenretinide; D009569:Nitric Oxide; D009828:Oleanolic Acid; C445068:bardoxolone methyl; D053148:Caspase 3