title: Covalent polymer-drug conjugates.
abstract: In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and polymer-proteins conjugates recently developed.
authors.affiliation: Institute of Polymer Science and Technology (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. ictep13@ictp.csic.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Elvira
authors.forename: Alberto
authors.initials: A
authors.lastname: Gallardo
authors.forename: Julio San
authors.initials: JS
authors.lastname: Roman
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cifuentes
mesh_terms: D016503:Drug Delivery Systems; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations; D011108:Polymers