title: In vivo stimulation on rabbit retina using CMOS LSI-based multi-chip flexible stimulator for retinal prosthesis.
abstract: We have performed in vivo electric stimulation experiments on rabbit retina to demonstrate feasibility of CMOS LSI-based multi-chip flexible neural stimulator for retinal prosthesis. We have developed new packaging structure with an improved flexibility and device control system which totally controls the LSI-based multi-chip stimulator, counter electrode, and stimulation generator. We have implanted the fabricated multi-chip stimulator into sclera pocket for STS (Suprachoroidal Transretinal Stimulation) configuration. We successfully obtained EEP (Electrically Evoked Potential) on visual cortex evoked by the multi-chip stimulator.
authors.affiliation: Nara Institute Science and Technology, Takayama-cho 8916-5, Ikoma, Nara, 630-0192, JAPAN. tokuda@ms.naist.jp
authors.forename: T
authors.initials: T
authors.lastname: Tokuda
authors.forename: R
authors.initials: R
authors.lastname: Asano
authors.forename: S
authors.initials: S
authors.lastname: Sugitani
authors.forename: Y
authors.initials: Y
authors.lastname: Terasawa
authors.forename: M
authors.initials: M
authors.lastname: Nunoshita
authors.forename: K
authors.initials: K
authors.lastname: Nakauchi
authors.forename: T
authors.initials: T
authors.lastname: Fujikado
authors.forename: Y
authors.initials: Y
authors.lastname: Tano
authors.forename: J
authors.initials: J
authors.lastname: Ohta
mesh_terms: D000818:Animals; D004056:Differential Threshold; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005074:Evoked Potentials, Visual / Q000502:physiology*; D019736:Prostheses and Implants; D011817:Rabbits; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000502:physiology*; D012666:Semiconductors; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013813:Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D014793:Visual Cortex / Q000502:physiology*