Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid.
An isonicotinoyldithiocarbazic acid (IN-DtczH) ligand, synthesized from isoniazid, was complexed with transition metals and evaluated for anti-mycobacterial activity as well as toxicity towards human-transformed rhabdomyosarcoma (RD) cells in vitro. Complexes with Ni, Co and Zn showed MIC of 2, 2 and 50 mug/ml against Mycobacterium tuberculosis H(37)Rv, and 10, 100 and 50 mug/ml against a multidrug-resistant strain of M. tuberculosis. They had little cytotoxic effect on the RD cells. In contrast, the Cu complex was highly cytotoxic with a low anti-mycobacterial activity.
Kanwar
S S
SS
Department of Biotechnology, Himachal Pradesh University, Shimla 171 005, India. kanwarss2000@yahoo.com
Lumba
K
K
Gupta
S K
SK
Katoch
V M
VM
Singh
P
P
Mishra
A K
AK
Kalia
S B
SB
D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007538:Isoniazid / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009532:Nickel / Q000737:chemistry; D012208:Rhabdomyosarcoma / Q000473:pathology; D015032:Zinc / Q000737:chemistry
D000995:Antitubercular Agents; D006834:Hydrazines; D008670:Metals; D003035:Cobalt; D009532:Nickel; D015032:Zinc; D007538:Isoniazid