title: Synthesis of novel, potentially biologically active dibenzosuberone derivatives.
abstract: Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries.
authors.affiliation: Belupo Pharmaceuticals & Cosmetics Ltd., Radnicka 224, 10000 Zagreb, Croatia. smerkas@irb.hr
authors.forename: Sonja
authors.initials: S
authors.lastname: Merkas
authors.forename: Mladen
authors.initials: M
authors.lastname: Litvić
authors.forename: Ivica
authors.initials: I
authors.lastname: Cepanec
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vinković
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011222:dibenzsuberone