Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients.
OBJECTIVE
To investigate the diagnostic efficacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP).


METHODS
A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic fluid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of >or= 250/mm(3).


RESULTS
Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specificity, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically significant effects on diagnostic accuracy.


CONCLUSIONS
Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP.
Torun
Serkan
S
Uludag University Medical School, Department of Internal Medicine, Bursa 16059, Turkey.
Dolar
Enver
E
Yilmaz
Yusuf
Y
Keskin
Murat
M
Kiyici
Murat
M
Sinirtas
Melda
M
Sarandol
Emre
E
Gurel
Selim
S
Nak
Selim-Giray
SG
Gulten
Macit
M
D000368:Aged; D001201:Ascites / Q000150:complications*; D002265:Carboxylic Ester Hydrolases / Q000032:analysis*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000032:analysis*; D010538:Peritonitis / Q000150:complications / Q000175:diagnosis*; D011934:Reagent Strips
D009573:Nitrites; D011934:Reagent Strips; C021443:leukocyte esterase; D002265:Carboxylic Ester Hydrolases