title: Possible remote functional reorganization in left temporal lobe epilepsy.
abstract: OBJECTIVE
  To provide functional magnetic resonance imaging-based insight into the impact of left temporal lobe epilepsy (TLE) on language-related functional re-organization.
  
  
  METHODS
  Ten right-handed patients with left TLE were compared with 10 matched healthy controls. Regional brain activation during the language task was measured in the inferior frontal gyrus (IFG) and in the superior temporal gyrus (STG), and the regional inter-hemispheric lateralization index (LI) was calculated.
  
  
  RESULTS
  Left language lateralization was documented in all the patients and controls. Reduced lateralization in the IFG was due to decreased activity in the left frontal region rather than to increased activity in the right frontal region. The LI values in the STG correlated with the LI values in the IFG in the controls but not in the patients.
  
  
  CONCLUSIONS
  The left IFG was most probably involved in the epileptogenesis and concomitant language-related cortical plasticity in patients with left TLE.
authors.affiliation: EEG and Epilepsy Unit, Department of Neurology, Wohl Institute for Advanced Imaging, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Kipervasser
authors.forename: D
authors.initials: D
authors.lastname: Palti
authors.forename: M Y
authors.initials: MY
authors.lastname: Neufeld
authors.forename: M
authors.initials: M
authors.lastname: Ben Shachar
authors.forename: F
authors.initials: F
authors.lastname: Andelman
authors.forename: I
authors.initials: I
authors.lastname: Fried
authors.forename: A D
authors.initials: AD
authors.lastname: Korczyn
authors.forename: T
authors.initials: T
authors.lastname: Hendler
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D032882:Comprehension / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D013702:Temporal Lobe / Q000098:blood supply / Q000503:physiopathology*
chemical_list: D010100:Oxygen