title: A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability.
abstract: By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.
authors.affiliation: Department of Organic and Industrial Chemistry, Viale G.P. Usberti 17a, University Campus, University of Parma, I-43100 - Parma, Italy. stefano.sforza@unipr.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Sforza
authors.forename: Tullia
authors.initials: T
authors.lastname: Tedeschi
authors.forename: Roberto
authors.initials: R
authors.lastname: Corradini
authors.forename: Rosangela
authors.initials: R
authors.lastname: Marchelli
mesh_terms: D004247:DNA / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D020135:Peptide Nucleic Acids; D004247:DNA; D008239:Lysine