title: Expression of HLA-G is associated with prognosis in esophageal squamous cell carcinoma.
abstract: The detection of HLA-G expression might serve as a clinical marker in the diagnosis or prediction of clinical outcomes for certain types of carcinoma. The aim of this study was to determine whether the detection of HLA-G has any important clinical applications for patients with esophageal squamous cell carcinoma (ESCC) by using immunohistochemical methods. We observed that the HLA-G protein was expressed in 90.9% (110/121) of the primary sites of ESCC but not in the normal esophageal tissues. The expression of HLA-G in the tumors was significantly correlated with histologic grade, depth of invasion, nodal status, host immune response, and clinical stage of disease. Patients with positive HLA-G expression had a significantly worse prognosis. In multivariate analysis, HLA-G was an independent prognostic factor. Our results indicate that expression of HLA-G is a characteristic feature of ESCC and suggest that immunostaining by anti-HLA-G antibodies may be a potentially useful prognostic indicator.
authors.affiliation: Core Laboratory of Sichuan Academy of Medical Sciences, Chengdu, Sichuan, Peoples Republic of China.
authors.forename: Shang-Mian
authors.initials: SM
authors.lastname: Yie
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Shang-Rong
authors.initials: SR
authors.lastname: Ye
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Dong
authors.forename: Xin-Mei
authors.initials: XM
authors.lastname: Lin
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006680:HLA Antigens / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I