title: Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.
abstract: Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.
authors.affiliation: MiraVista Diagnostics and MiraBella Technologies, Indianapolis, IN 46241, USA.
authors.forename: David
authors.initials: D
authors.lastname: Zhuang
authors.forename: Melinda
authors.initials: M
authors.lastname: Smedema
authors.forename: Ann
authors.initials: A
authors.lastname: Lemonte
authors.forename: Benita K
authors.initials: BK
authors.lastname: Book
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
mesh_terms: D000935:Antifungal Agents / Q000097:blood*; D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000097:blood; D004347:Drug Interactions; D005189:False Positive Reactions; D006086:Graft vs Host Disease / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D008828:Microbiological Techniques; D020123:Sirolimus / Q000097:blood; D016559:Tacrolimus / Q000097:blood; D014230:Triazoles / Q000097:blood*
chemical_list: D000935:Antifungal Agents; D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D014230:Triazoles; C101425:posaconazole; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus