[Bacteria isolated from perforation peritonitis and their antimicrobial susceptibilities].
Bacteria isolated from 25 cases of perforation peritonitis and its antimicrobial susceptibilities were studied. One hundred and forty-six strains including 36 strains of aerobic bacteria, 107 strains of anaerobic bacteria and 3 strains of yeast were isolated from intra-peritoneal fluid obtained at operation. Among aerobic bacteria, Enterobacteriaceae was isolated from 13 cases (52%) out of all, and followed by those of Enterococcus spp. (24%), Pseudomonas aeruginosa (20%), in this order. Among non-spore forming anaerobic Gram-negative bacteria, the isolation rate of Bacteroides fragilis group (64%) was highest, followed by Fusobacterium spp. (40%), Prevotella spp./Porphyromonas spp. (32%) and Bilophila wadsworthia (28%), in this order. The isolation rate of non-spore forming anaerobic Gram-positive bacteria was 60%, and that of Clostridium spp. was 24%. Even by the recent advanced methods, there were 17 strains of anaerobic bacteria, which were not identified by phenotypic-identification levels. Carbapenems and beta-lactams plus beta-lactamase inhibitors have strong antimicrobial activities against both aerobic and anaerobic bacteria. Although metronidazole and minocycline have strong activities against anaerobic bacteria, there were many strains highly resistant to clindamycin.
Shinagawa
Nagao
N
Department of Surgery, NTT West Tokai Hospital.
Tanaka
Kaori
K
Mikamo
Hiroshige
H
Watanabe
Kunitomo
K
Takeyama
Hiromitsu
H
Yokoyama
Takashi
T
Takesue
Yoshio
Y
Taniguchi
Masaaki
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D007416:Intestinal Perforation / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D047090:beta-Lactams