Salmonellae interplay with host cells.
Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of the molecular mechanisms that underpin the interactions of salmonellae with their animal hosts has advanced greatly over the past decade, mainly through the study of Salmonella enterica serovar Typhimurium in tissue culture and animal models of infection. Knowledge of these bacterial processes and host responses has painted a dynamic and complex picture of the interaction between salmonellae and animal cells. This Review focuses on the molecular mechanisms of these host-pathogen interactions, in terms of their context, significance and future perspectives.
Haraga
Andrea
A
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Ohlson
Maikke B
MB
Miller
Samuel I
SI
D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology*; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000502:physiology*