Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.
Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.
Zhuang
David
D
MiraVista Diagnostics and MiraBella Technologies, Indianapolis, IN 46241, USA.
Smedema
Melinda
M
Lemonte
Ann
A
Book
Benita K
BK
Pescovitz
Mark D
MD
Wheat
L Joseph
LJ
D000935:Antifungal Agents / Q000097:blood*; D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000097:blood; D004347:Drug Interactions; D005189:False Positive Reactions; D006086:Graft vs Host Disease / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D008828:Microbiological Techniques; D020123:Sirolimus / Q000097:blood; D016559:Tacrolimus / Q000097:blood; D014230:Triazoles / Q000097:blood*
D000935:Antifungal Agents; D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D014230:Triazoles; C101425:posaconazole; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus