RecBCD: the supercar of DNA repair.
The DNA helicase RecBCD pauses when it reaches recombination hotspots known as Chi sites and then proceeds at a slower speed of translocation than before Chi recognition. Reporting in this issue, Spies et al. (2007) now show that this reduction in translocation velocity occurs when RecBCD changes which of its two motor subunits is in the lead.
Wigley
Dale B
DB
Cancer Research UK Clare Hall Laboratories, The London Research Institute, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3LD, UK. dale.wigley@cancer.org.uk
D004260:DNA Repair; D043211:Exodeoxyribonuclease V / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D011995:Recombination, Genetic
D021122:Protein Subunits; D043211:Exodeoxyribonuclease V