Population pharmacokinetics of micafungin in adult patients.
We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those <66.3 kg. However, the clinical implications are still unknown.
Gumbo
Tawanda
T
Ordway Research Institute, Albany, NY 12208, USA. tawanda.gumbo@utsouthwestern.edu
Hiemenz
John
J
Ma
Lei
L
Keirns
James J
JJ
Buell
Donald N
DN
Drusano
George L
GL
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D054714:Echinocandins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D000077551:Micafungin; D008875:Middle Aged; D044967:Serum / Q000737:chemistry
D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D000077551:Micafungin