Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones.
Patients with renal stones are known to be at risk of clinical complications such as cardiovascular disease (CVD), nephropathy, and cancer. Recently, it has been realized that almost all risk markers for CVD, nephropathy, etc. are all markers associated with the sequence of reactions of chronic inflammation. It has been reported that chronic inflammation is involved not only in the pathogenesis of nephrolithiasis but also contributes to the development of clinical complications in this condition; therefore, we decided to find out whether these multiple markers are detectable in patients with renal stones so that they can be used to predict the risk of clinical complications in these patients. There were 33 patients with nephrolithiasis included in this study. We found that almost all major markers of chronic inflammation were elevated in patients with renal stones, including proinflammatory cytokine, acute inflammation markers, adhesion molecules, urinary microalbumin (uMA), myeloperoxidase (MPO), 8-hydroxydeoxyguanosine (8-OHdG), 3-nitrotyrosine (3NT), and monocyte chemoattractant protein. It appears that it is possible to assess the risk of clinical complications by monitoring these markers in patients with renal stones.
Tsao
Kuo-Chien
KC
Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Wu
Tsu-Lan
TL
Chang
Pi-Yueh
PY
Sun
Chien-Feng
CF
Wu
Lily L
LL
Wu
James T
JT
D000328:Adult; D000419:Albuminuria / Q000652:urine; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology; D015415:Biomarkers / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007669:Kidney Calculi / Q000097:blood* / Q000150:complications; D008297:Male; D009589:Nitrogen Oxides / Q000378:metabolism; D018384:Oxidative Stress; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D018932:Chemokine CCL2; D009589:Nitrogen Oxides