An expedient, facile and simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles from the Baylis-Hillman bromides in aqueous media.
This protocol is for an expedient and operationally simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles in high yields from the corresponding Baylis-Hillman bromides. The reaction proceeds via the successive treatment with 1,4-diazabicyclo(2.2.2)octane (DABCO) for 15 min and sodium borohydride for 15 min in aqueous media [tetrahydrofuran (THF):H2O (1:1)] at room temperature.
Basavaiah
Deevi
D
School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. dbsc@uohyd.ernet.in
Reddy
Kanumuri Ramesh
KR
Kumaragurubaran
Nagaswamy
N
D001965:Bromides / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry
C526598:2-methylene-3-phenylpropanenitrile; D001965:Bromides; D009570:Nitriles; D010666:Phenylpropionates; C526597:methyl 2-methylene-3-phenylpropanoate