A novel domino-click approach for the synthesis of sugar based unsymmetrical bis-1,2,3-triazoles.
Aryl or sugar azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted-butynyl-N-aryl or N-glycosyl-1,2,3-bistriazoles in a domino fashion. Upon Cu(I) catalyzed 1,3-dipolar cycloaddition with sugar azides, these compounds afford novel unsymmetrical bis-1,2,3-triazoles in high yields.
Arora
Bhupinder Singh
BS
Synthetic Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180 001, India.
Shafi
Syed
S
Singh
Swarn
S
Ismail
Tabasum
T
Kumar
H M Sampath
HM
D001386:Azides / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D014230:Triazoles / Q000138:chemical synthesis*
D001386:Azides; D002241:Carbohydrates; D014230:Triazoles; D003300:Copper