Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands.
A novel series of bis(pyrrol-2-yl-methyleneamine) ligands H2L(n) (n = 1-4) were synthesized via condensation of diamines with two equivalents of 2-formyl-pyrrole (2). Their Zn(II) complexes were characterized by elemental analyses, mass spectra and IR spectra. The crystal structures of [ZnL(1)]2 and [ZnL(4)]2 obtained from ethanol solution was determined by X-ray diffraction analysis, each of them possesses a double-stranded helical geometry. In addition, the DNA-binding properties of the compounds have been fully investigated by absorption, fluorescence and viscosity measurements.
Wang
Yuan
Y
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Yang
Zheng-Yin
ZY
Chen
Zhong-Ning
ZN
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D015032:Zinc / Q000737:chemistry*
D000588:Amines; D008024:Ligands; D009942:Organometallic Compounds; D011758:Pyrroles; D004247:DNA; C427203:calf thymus DNA; D015032:Zinc