title: The decline in paediatric malaria admissions on the coast of Kenya.
abstract: BACKGROUND
  There is only limited information on the health impact of expanded coverage of malaria control and preventative strategies in Africa.
  
  
  METHODS
  Paediatric admission data were assembled over 8.25 years from three District Hospitals; Kilifi, Msambweni and Malindi, situated along the Kenyan Coast. Trends in monthly malaria admissions between January 1999 and March 2007 were analysed using several time-series models that adjusted for monthly non-malaria admission rates and the seasonality and trends in rainfall.
  
  
  RESULTS
  Since January 1999 paediatric malaria admissions have significantly declined at all hospitals. This trend was observed against a background of rising or constant non-malaria admissions and unaffected by long-term rainfall throughout the surveillance period. By March 2007 the estimated proportional decline in malaria cases was 63% in Kilifi, 53% in Kwale and 28% in Malindi. Time-series models strongly suggest that the observed decline in malaria admissions was a result of malaria-specific control efforts in the hospital catchment areas.
  
  
  CONCLUSIONS
  This study provides evidence of a changing disease burden on the Kenyan coast and that the most parsimonious explanation is an expansion in the coverage of interventions such as the use of insecticide-treated nets and the availability of anti-malarial medicines. While specific attribution to intervention coverage cannot be computed what is clear is that this area of Kenya is experiencing a malaria epidemiological transition.
authors.affiliation: Malaria Public Health & Epidemiology Group, Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute/Wellcome Trust Research Programme, P,O, Box 43640, 00100 GPO, Nairobi, Kenya. eokiro@nairobi.kemri-wellcome.org
authors.forename: Emelda A
authors.initials: EA
authors.lastname: Okiro
authors.forename: Simon I
authors.initials: SI
authors.lastname: Hay
authors.forename: Priscilla W
authors.initials: PW
authors.lastname: Gikandi
authors.forename: Shahnaaz K
authors.initials: SK
authors.lastname: Sharif
authors.forename: Abdisalan M
authors.initials: AM
authors.lastname: Noor
authors.forename: Norbert
authors.initials: N
authors.lastname: Peshu
authors.forename: Kevin
authors.initials: K
authors.lastname: Marsh
authors.forename: Robert W
authors.initials: RW
authors.lastname: Snow
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006767:Hospitals, District; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D016014:Linear Models; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology*; D010343:Patient Admission / Q000706:statistics & numerical data*; D011159:Population Surveillance; D011891:Rain; D012621:Seasons