title: Therapeutic applications of mesenchymal stromal cells.
abstract: Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an "off-the-shelf" therapeutic product.
authors.affiliation: Adult Stem Cell Laboratory, Biotherapy Program, Mater Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Gary
authors.initials: G
authors.lastname: Brooke
authors.forename: Matthew
authors.initials: M
authors.lastname: Cook
authors.forename: Chris
authors.initials: C
authors.lastname: Blair
authors.forename: Rachel
authors.initials: R
authors.lastname: Han
authors.forename: Celena
authors.initials: C
authors.lastname: Heazlewood
authors.forename: Ben
authors.initials: B
authors.lastname: Jones
authors.forename: Melinda
authors.initials: M
authors.lastname: Kambouris
authors.forename: Kate
authors.initials: K
authors.lastname: Kollar
authors.forename: Steven
authors.initials: S
authors.lastname: McTaggart
authors.forename: Rebecca
authors.initials: R
authors.lastname: Pelekanos
authors.forename: Alison
authors.initials: A
authors.lastname: Rice
authors.forename: Tony
authors.initials: T
authors.lastname: Rossetti
authors.forename: Kerry
authors.initials: K
authors.lastname: Atkinson
mesh_terms: D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D039902:Multipotent Stem Cells / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology / Q000637:transplantation