title: [Echinomycin production by Actinomadura sp. INA 654].
abstract: An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II. Investigation of their physico-chemical properties showed that A-654-I was identical to echinomycin, a heteropeptide lactone of the quinoxaline group with antitumor activity, while A-654-II proved to be likely a new natural compound. Production of echinomycin by a representative of the Actinomadura genus was detected for the first time. Up to now, only representatives of the Streptomyces genus were known to produce echinomycin.
authors.forename: O A
authors.initials: OA
authors.lastname: Galatenko
authors.forename: L P
authors.initials: LP
authors.lastname: Terekhova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Li
authors.forename: N D
authors.initials: ND
authors.lastname: Malkina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Boĭkova
authors.forename: V A
authors.initials: VA
authors.lastname: Zenkova
authors.forename: G S
authors.initials: GS
authors.lastname: Katrukha
mesh_terms: D039903:Actinobacteria / Q000302:isolation & purification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004448:Echinomycin / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012426:Russia; D012988:Soil Microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004448:Echinomycin