title: Reactions of 3-formylchromone with active methylene and methyl compounds and some subsequent reactions of the resulting condensation products.
abstract: This review presents a survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc. The utilisation of the condensation products for the synthesis of different heterocyclic systems, which is based on the ability of the gamma-pyrone ring to be opened by the nucleophilic attack is also reviewed. Finally, the applications of microwave irradiation as an unconventional method of reaction activation in the synthesis of condensation products is described and the biological activity of some chromone derivatives is noted.
authors.affiliation: Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Slovak Republic. renata.gasparova@ucm.sk
authors.forename: Renata
authors.initials: R
authors.lastname: Gasparová
authors.forename: Margita
authors.initials: M
authors.lastname: Lácová
mesh_terms: D000085:Acetates / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry; D001463:Barbiturates / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D002867:Chromones / Q000737:chemistry*; D004136:Dinitrobenzenes / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D006626:Hippurates / Q000737:chemistry; D006838:Hydrocarbons / Q000737:chemistry*; D008956:Models, Chemical; D010422:Pentanones / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D011809:Quinones / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000085:Acetates; D000097:Acetonitriles; D001463:Barbiturates; D001565:Benzoates; D002867:Chromones; D004136:Dinitrobenzenes; D004146:Dioxanes; D006571:Heterocyclic Compounds; D006626:Hippurates; D006838:Hydrocarbons; D010422:Pentanones; D010648:Phenylacetates; D011422:Propionates; D011809:Quinones; D013450:Sulfones; D013844:Thiazoles; C400972:benzoylpropionic acid; C502480:formylchromone; C008790:acetylacetone; C007650:ethyl acetate; C076489:Meldrum's acid; C025136:phenylacetic acid; C030514:hippuric acid; D005998:Glycine; C006368:aceturic acid; C032232:barbituric acid