title: Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia.
abstract: We report a fifty-year-old woman presenting with severe aplastic anaemia (SAA) and prolonged high Human Herpesvirus 6 (HHV6) variant A DNAeamia detected by quantitative PCR. Multiple antiviral treatments failed to affect the HHV6 DNAemia and subsequent immunosuppressive treatment reached only partial improvement as judged by bone marrow examinations. The patient remained dependent on thrombocyte transfusions and G-CSF treatment. After one year of steady high HHV6 DNA load in blood, viral chromosomal integration was proved by demonstrating the viral DNA in hair follicles. This condition appeared to be unconnected with, and to have no effect, on the original SAA.
authors.affiliation: Department of Paediatric Haematology and Oncology, Motol University Hospital, Prague, The Czech Republic. Petr.Hubacek@Lfmotol.cuni.cz
authors.forename: P
authors.initials: P
authors.lastname: Hubacek
authors.forename: J
authors.initials: J
authors.lastname: Maalouf
authors.forename: M
authors.initials: M
authors.lastname: Zajickova
authors.forename: M
authors.initials: M
authors.lastname: Kouba
authors.forename: O
authors.initials: O
authors.lastname: Cinek
authors.forename: K
authors.initials: K
authors.lastname: Hyncicova
authors.forename: I
authors.initials: I
authors.lastname: Fales
authors.forename: P
authors.initials: P
authors.lastname: Cetkovsky
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy* / Q000235:genetics* / Q000821:virology; D000998:Antiviral Agents / Q000627:therapeutic use*; D002875:Chromosomes / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D024882:Drug Resistance, Viral / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral