title: Associations of isoprostanes-related oxidative stress with surrogate subclinical indices and angiographic measures of atherosclerosis.
abstract: OBJECTIVE
  Cardiovascular diseases are the most common cause of death in the world. Oxidative stress has been proved to play a role in atherosclerotic diseases and 8-isoprostane is one of the most valid markers of in-vivo oxidative stress. We aimed to investigate the 8-isoprostane levels in relation to surrogate and direct angiographic indexes of atherosclerosis.
  
  
  METHODS
  Urinary 8-isoprostane levels were measured and a B-mode carotid ultrasound examination was performed in 100 consecutive patients scheduled for coronary angiography.
  
  
  RESULTS
  In patients with angiographic coronary artery disease (CAD) urinary 8-isoprostane levels were significantly (P<0.001) higher than in patients without CAD (68.75+/-5.5 vs. 38.27+/-3.7 pg/ml). Moreover, 8-isoprostane levels of patients with increased carotid intima media thickness (CIMT) were higher (P<0.001) than in patients with normal CIMT values (75.12+/-6.4 vs. 38.72+/-2.7 pg/ml). Moreover log(8-isoprostane) levels were significantly correlated with maximum and mean CIMT values (P<0.001) and across univessel and multivessel CAD groups levels of log(8-isoprostane) showed a significantly (P<0.001) increasing trend. Logistic regression analysis revealed that 8-isoprostane levels were an independent predictor for both intima-media thickening and angiographic CAD.
  
  
  CONCLUSIONS
  These findings indicate that elevated urinary levels of 8-isoprostane are associated with both subclinical atherosclerosis and manifest CAD. The results therefore support the hypothesis that isoprostanes-related oxidative stress is involved in the whole atherosclerotic process.
authors.affiliation: Akdeniz University School of Medicine, Department of Cardiology, Antalya, Turkey. ibasarici@akdeniz.edu.tr
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Basarici
authors.forename: Refik Emre
authors.initials: RE
authors.lastname: Altekin
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Demir
authors.forename: Huseyin
authors.initials: H
authors.lastname: Yilmaz
mesh_terms: D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017023:Coronary Angiography; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000502:physiology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014463:Ultrasonography
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost