The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs.
The expedient synthesis of 1,5-benzothiazepines using LaY zeolite under stirring condition is reported and synthesized compound screened for cytotoxic activity. The reaction produces the product in relatively low yields and requires a long time when they were performed in various solvents under conventional and microwave irradiation. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions.
Arya
Kapil
K
Indian Oil Corporation Limited, R&D Centre, Faridabad, Haryana 121007, India. aryakapil2001@yahoo.com
Dandia
Anshu
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D017641:Zeolites / Q000737:chemistry
C106746:1,5-benzothiazepine; D000970:Antineoplastic Agents; D013841:Thiazepines; D017641:Zeolites