Exploiting cholera vaccines as a versatile antigen delivery platform.
The development of safe, immunogenic and protective cholera vaccine candidates makes possible their use as a versatile antigen delivery platform. Foreign antigens can be delivered to the immune system with cholera vaccines by expressing heterologous antigens in live attenuated vectors, as fusion proteins with cholera toxin subunits combined with inactivated Vibrio cholerae whole cells or by exposing them on the surface of V. cholerae ghosts. Progress in our understanding of the genes expressed by V. cholerae during infection creates unprecedented opportunities to develop an improved generation of vaccine vectors to induce immune protection against a broad range of pathogenic organisms.
Silva
Anisia J
AJ
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr., SW Atlanta, GA 30310, USA. asilva-benitez@msm.edu
Eko
Francis O
FO
Benitez
Jorge A
JA
D000942:Antigens, Bacterial / Q000276:immunology*; D002771:Cholera / Q000276:immunology / Q000517:prevention & control; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014734:Vibrio cholerae / Q000276:immunology*
D000942:Antigens, Bacterial; D022121:Cholera Vaccines