title: VIOLIN: vaccine investigation and online information network.
abstract: Vaccines are among the most efficacious and cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The vaccine investigation and online information network (VIOLIN) is a web-based central resource, allowing easy curation, comparison and analysis of vaccine-related research data across various human pathogens (e.g. Haemophilus influenzae, human immunodeficiency virus (HIV) and Plasmodium falciparum) of medical importance and across humans, other natural hosts and laboratory animals. Vaccine-related peer-reviewed literature data have been downloaded into the database from PubMed and are searchable through various literature search programs. Vaccine data are also annotated, edited and submitted to the database through a web-based interactive system that integrates efficient computational literature mining and accurate manual curation. Curated information includes general microbial pathogenesis and host protective immunity, vaccine preparation and characteristics, stimulated host responses after vaccination and protection efficacy after challenge. Vaccine-related pathogen and host genes are also annotated and available for searching through customized BLAST programs. All VIOLIN data are available for download in an eXtensible Markup Language (XML)-based data exchange format. VIOLIN is expected to become a centralized source of vaccine information and to provide investigators in basic and clinical sciences with curated data and bioinformatics tools for vaccine research and development. VIOLIN is publicly available at http://www.violinet.org.
authors.affiliation: Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Zuoshuang
authors.initials: Z
authors.lastname: Xiang
authors.forename: Thomas
authors.initials: T
authors.lastname: Todd
authors.forename: Kim P
authors.initials: KP
authors.lastname: Ku
authors.forename: Bethany L
authors.initials: BL
authors.lastname: Kovacic
authors.forename: Charles B
authors.initials: CB
authors.lastname: Larson
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Hodges
authors.forename: Yuying
authors.initials: Y
authors.lastname: Tian
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Olenzek
authors.forename: Boyang
authors.initials: B
authors.lastname: Zhao
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Colby
authors.forename: Howard G
authors.initials: HG
authors.lastname: Rush
authors.forename: Janet R
authors.initials: JR
authors.lastname: Gilsdorf
authors.forename: George W
authors.initials: GW
authors.lastname: Jourdian
authors.forename: Yongqun
authors.initials: Y
authors.lastname: He
mesh_terms: D000818:Animals; D016208:Databases, Factual; D006801:Humans; D007255:Information Services; D020407:Internet; D039781:PubMed; D016415:Sequence Alignment; D014584:User-Computer Interface; D014612:Vaccines / Q000235:genetics / Q000276:immunology
chemical_list: D014612:Vaccines