Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv.
Three xanthones, polyanxanthone A (1), B (2) and C (3) have been isolated from the methanol extract of the wood trunk of Garcinia polyantha, along with five known xanthones: 1,3,5-trihydroxyxanthone (4); 1,5-dihydroxyxanthone (5); 1,3,6,7-tetrahydroxyxanthone (6); 1,6-dihydroxy-5-methoxyxanthone (7) and 1,3,5,6-tetrahydroxyxanthone (8). Their structures were determined by means of 1D- and 2D-NMR techniques. Some of the above compounds were screened for their anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.
Louh
Gabin Nselapi
GN
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Lannang
Alain Meli
AM
Mbazoa
Celine Djama
CD
Tangmouo
Jean Gustave
JG
Komguem
Justin
J
Castilho
Paula
P
Ngninzeko
Fernande Ngounou
FN
Qamar
Naz
N
Lontsi
David
D
Choudhary
Muhammad Iqbal
MI
Sondengam
Beiban Luc
BL
D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014934:Wood / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D044004:Xanthones; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase