A convergent synthesis of polysubstituted aromatic nitriles via palladium-catalyzed C-H functionalization.
A palladium-catalyzed C-H functionalization reaction for the synthesis of highly substituted aromatic nitriles is reported. The modularity of the reaction is demonstrated by the broad range of aryl iodides which can be coupled with metal cyanides and alkyl halides or aryl bromides.
Mariampillai
Brian
B
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
Alliot
Julien
J
Li
Mengzhou
M
Lautens
Mark
M
D000478:Alkylation; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009636:Norbornanes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D001555:Benzene Derivatives; D006846:Hydrocarbons, Halogenated; D009570:Nitriles; D009636:Norbornanes; D010165:Palladium