title: An ethnopharmacological study of medicinal plants in New South Wales.
abstract: The Australian Aboriginal people have used plants as medicine and food for thousands of years, however, this traditional knowledge is documented only to a limited extent, and is in danger of being lost. The Indigenous Bioresources Research Group (IBRG) aims to help Australian Aboriginal communities to preserve their customary medicinal knowledge, and to provide information that can be used for their cultural or educational purposes, as well as for scientific advancement. This work is undertaken in close collaboration with Australian Aboriginal communities in New South Wales. The project is multidisciplinary, combining an ethnobotanical and an ethnopharmacological approach, which includes biological and chemical investigations, as well as developing best practices for protecting traditional knowledge. This paper describes the general strategy of the project as well as methods used in the ethnopharmacological study. Ethnobotanical databases are set up for each participating community. Plant material is collected, extracted, and active compounds are isolated using a bioassay-guided fractionation approach. All extracts and compounds are tested for biological activity in antimicrobial assays (disc diffusion, resazurin, fluorescein diacetate), neurological assays or anti-inflammatory assays, depending on their traditional use.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
authors.forename: Nynke
authors.initials: N
authors.lastname: Brouwer
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: David
authors.initials: D
authors.lastname: Harrington
authors.forename: James
authors.initials: J
authors.lastname: Kohen
authors.forename: Subramanyam
authors.initials: S
authors.lastname: Vemulpad
authors.forename: Joanne
authors.initials: J
authors.lastname: Jamie
authors.forename: Michael
authors.initials: M
authors.lastname: Randall
authors.forename: Deidre
authors.initials: D
authors.lastname: Randall
mesh_terms: D000818:Animals; D001315:Australia; D005452:Fluoresceins / Q000494:pharmacology; D006801:Humans; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D009865:Oocytes / Q000187:drug effects; D010078:Oxazines / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014966:Xanthenes / Q000494:pharmacology; D014981:Xenopus
chemical_list: D005452:Fluoresceins; D010078:Oxazines; D010936:Plant Extracts; D014966:Xanthenes; C005843:resazurin; C018506:diacetylfluorescein