Preeclampsia: impaired inflammatory response mediated by Toll-like receptors.
Monocytes may be activated in preeclampsia (PE). Toll-like receptor (TLR)-4 and TLR-2 are involved in inflammatory responses of monocytes. The objective of this study was to evaluate the production of tumor necrosis factor (TNF), an inflammatory cytokine, and interleukin (IL)-10, an immunoregulatory cytokine, by monocytes from PE patients stimulated with TLR ligands. TLR-4 and TLR-2 responses were similar in normal pregnancy and non-pregnant women. The production of TNF by monocytes stimulated with TLR ligands was significantly impaired in PE, whereas IL-10 production was not affected. The imbalance between an inflammatory and anti-inflammatory pattern of monocytes may play a role in PE pathophysiology.
Mazouni
Chafika
C
Department of Obstetrics and Gynecology, Hôpital de la Conception, 147 Bld. Baille, 13005 Marseille cedex 20, France.
Capo
Christian
C
Ledu
Renaud
R
Honstettre
Amélie
A
Agostini
Aubert
A
Capelle
Marianne
M
Mege
Jean-Louis
JL
Bretelle
Florence
F
D000328:Adult; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D016753:Interleukin-10 / Q000276:immunology*; D008024:Ligands; D009000:Monocytes / Q000276:immunology* / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000819:agonists / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000819:agonists / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
C508609:IL10 protein, human; D008024:Ligands; C495342:TLR2 protein, human; C495345:TLR4 protein, human; C439524:TNF protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10