Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient.
Between 2000 and 2004, dengue virus type 1 (DENV-1) genotypes I and II from Asia were introduced into the Pacific region and co-circulated in some localities. Envelope protein gene sequences of DENV-1 from 12 patients infected on the island of New Caledonia were obtained, five of which carried genotype I viruses and six, genotype II viruses. One patient harboured a mixed infection, containing viruses assigned to both genotypes I and II, as well as a number of inter-genotypic recombinants. This is the first report of a population of dengue viruses isolated from a patient containing both parental and recombinant viruses.
Aaskov
John
J
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Buzacott
Katie
K
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Field
Emma
E
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Lowry
Kym
K
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Berlioz-Arthaud
Alain
A
Institute Pasteur, Noumea, New Caledonia.
Holmes
Edward C
EC
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.|Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA.
D000818:Animals; D002460:Cell Line; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000235:genetics*; D004196:Disease Outbreaks; D006801:Humans; D017720:Molecular Epidemiology; D009510:New Caledonia / Q000453:epidemiology; D010802:Phylogeny; D011995:Recombination, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics*
D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus