title: Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure.
abstract: We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca(2+)-ATPase, phospholamban, beta1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca(2+)-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the beta1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca(2+)-ATPase and beta1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
authors.affiliation: Department of Balneology and Physiotherapy, S. M. Kirov Military Medical Academy, St. Petersburg. denis.kovlen@mail.ru
authors.forename: D V
authors.initials: DV
authors.lastname: Kovlen
authors.forename: A Yu
authors.initials: AY
authors.lastname: Tishakov
authors.forename: O S
authors.initials: OS
authors.lastname: Glotov
authors.forename: M V
authors.initials: MV
authors.lastname: Moskalenko
authors.forename: G S
authors.initials: GS
authors.lastname: Demin
authors.forename: A N
authors.initials: AN
authors.lastname: Bitsadze
authors.forename: A V
authors.initials: AV
authors.lastname: Chernyshev
authors.forename: N I
authors.initials: NI
authors.lastname: Bratova
authors.forename: T E
authors.initials: TE
authors.lastname: Ivashchenko
authors.forename: A G
authors.initials: AG
authors.lastname: Obrezan
authors.forename: G N
authors.initials: GN
authors.lastname: Ponomarenko
mesh_terms: D000368:Aged; D002135:Calcium-Binding Proteins / Q000235:genetics; D000252:Calcium-Transporting ATPases / Q000235:genetics; D002908:Chronic Disease; D002980:Climate; D005260:Female; D006294:Health Resorts; D006333:Heart Failure / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics; D016138:Walking; D000099211:Phospholamban
chemical_list: D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D007334:Insulin-Like Growth Factor I; D018342:Receptors, Adrenergic, beta-1; D000099211:Phospholamban