[Effect of enalapril on diabetic rat myocardial ultrastructure].
OBJECTIVE
To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment.


METHODS
Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection. Histological analysis of the left ventricular tissue was performed with transmission electron microscope 1, 3, and 5 months after establishment of diabetes.


RESULTS
Onset of myocardial damages was observed 1 month after the development of diabetes in the rats with gradual time-dependent exacerbation. Enalapril treatment could partially reverse the myocardial destruction in the diabetic rats.


CONCLUSIONS
Enalapril intervention may improve the ultrastructural pathology of the myocardium in diabetic rats, which is suggestive of the action mechanisms of angiotensin-converting enzyme inhibitors in myocardium preservation.
Xu
Chun-sheng
CS
Emergency Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xusheng909@sina.com
Li
Zhi-liang
ZL
Xue
Shi-rong
SR
Yan
Quan-neng
QN
Wu
Hong-chao
HC
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology*; D004656:Enalapril / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D000806:Angiotensin-Converting Enzyme Inhibitors; D013311:Streptozocin; D004656:Enalapril