Macrophage peroxisome proliferator activated receptor gamma as a therapeutic target to combat Type 2 diabetes.
The peroxisome proliferator activated receptor gamma is a member of the nuclear receptor superfamily of ligand-dependent transcription factors and is the molecular target of antidiabetic thiazolidinediones that exert insulin sensitizing effects in adipose tissue, skeletal muscle and the liver. In addition to the well described effects of peroxisome proliferator activated receptor gamma in insulin target tissues, it is now apparent that its expression in macrophages is critical in the regulation of macrophage phenotype, whole body glucose metabolism and in mediating, in part, the antidiabetic actions of thiazolidinediones. As macrophages are major contributors to tissue inflammation and are resident in tissues responsible for maintaining glucose homeostasis, the therapeutic potential of these cells in the treatment of Type 2 diabetes is of significant clinical interest.
Pascual
Gabriel
G
University of California, Department of Cellular Molecular Medicine, La Jolla, San Diego, California 92093, USA.
Ricote
Mercedes
M
Hevener
Andrea L
AL
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D016503:Drug Delivery Systems; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D008264:Macrophages / Q000378:metabolism; D047495:PPAR gamma / Q000187:drug effects* / Q000378:metabolism; D045162:Thiazolidinediones / Q000008:administration & dosage
D007004:Hypoglycemic Agents; D047495:PPAR gamma; D045162:Thiazolidinediones; D005947:Glucose