title: Chemistry of osmium-DNA complexes.
abstract: A precise chemistry of ternary complex formation between osmium reagents, 2,2'-bipyridine (Bpy) and DNA strand has been characterized. Enzymatically digested products of ternary complexes formed for a thymidine in an oligonucleotide has given two diastereoisomers corresponding the 5S,6R- and 5R,6S-isomers of T-Os-Bpy in 70:30 ratio.
authors.affiliation: Frontier Research System, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umemoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tainaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Okamoto
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004277:DNA, Single-Stranded / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry*; D013237:Stereoisomerism; D013936:Thymidine / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; D009992:Osmium; D015082:2,2'-Dipyridyl; D013936:Thymidine