[In vivo/in vitro evaluation of Kangfuxin colon targeting capsules].
OBJECTIVE
To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro.


METHODS
The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo.


RESULTS
After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours.


CONCLUSIONS
Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.
Qiu
Xue-lan
XL
Chengdu University of Traditional Chinanese Medicine, Chengdu 611730, China.
Yang
Ming
M
Xie
Xing-liang
XL
Lai
Juan
J
Chen
Si-wei
SW
D000818:Animals; D002214:Capsules; D003106:Colon / Q000000981:diagnostic imaging / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010526:Periplaneta / Q000737:chemistry; D011096:Polygalacturonase / Q000737:chemistry; D011859:Radiography
D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008419:Materia Medica; D011096:Polygalacturonase