title: [Specifics of cytokine regulation in tick-borne encephalitis and Lyme borreliosis].
abstract: The aim of the study was to evaluate the dynamics of T-lymphocyte cytokine profile during the acute period of tick-bore encephalitis (febrile and meningeal forms) and non-erythematous Lyme borreliosis (NELB). ELISA (Vector-Best, Novosybirsk) and IHA (Virion, Tomsk) techniques were used for laboratory diagnostics of tick-borne encephalitis (TBE). Etiological verification of Lyme borreliosis (LB) was performed using immune-enzyme test systems for detection of IgG and IgM antibodies to Borellia burgdorferi (NOVATEC Immunodiagnostica, Germany). Thirty-eight subjects constituted the meningeal TBE group; the febrile TBE group consisted of 25 subjects. NELB was diagnosed in 20 subjects. Immunological tests were performed on days 1-7, 8-14, 15-21, and 22-28 of the disease. The study found that primary T-lymphocytes prevailed at early stages during the acute period of febrile TBE. In NELB, secondary T-lymphocytes were registered beginning from days 15-21. Meningeal TBE was characterized by a deep reduction in IFNgamma-producing CD3+ lymphocyte reserve.
authors.forename: Ia B
authors.initials: IaB
authors.lastname: Beĭkin
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Lagereva
authors.forename: M G
authors.initials: MG
authors.lastname: Toporkova
authors.forename: L G
authors.initials: LG
authors.lastname: Besedina
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Druzhinina
mesh_terms: D000208:Acute Disease; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D025065:Borrelia burgdorferi / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007159:Immunologic Tests; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015847:Interleukin-4; D007371:Interferon-gamma