A novel approach in cinnamic acid synthesis: direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of boron tribromide.
Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190 degrees C) for 8-12 hours.
Chiriac
Constantin I
CI
Institute of Macromolecular Chemistry Petru Poni, Aleea Grigore Ghica Voda 41 A, Iasi - 700487, Romania. cchiriac@poni.icmpp.tuiasi.ro
Tanasa
Fulga
F
Onciu
Marioara
M
D000447:Aldehydes / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology*; D001965:Bromides / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D002934:Cinnamates / Q000138:chemical synthesis*; D005227:Fatty Acids / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D008954:Models, Biological
D000447:Aldehydes; D001896:Boron Compounds; D001965:Bromides; D002264:Carboxylic Acids; D002934:Cinnamates; D005227:Fatty Acids; D006571:Heterocyclic Compounds; C029010:cinnamic acid