title: Low-frequency distortion product otoacoustic emission test compared to ECoG in diagnosing endolymphatic hydrops.
abstract: Previous studies assumed that specific audiometric measures like low-frequency biasing were noninvasive and inexpensive techniques for diagnosing endolymphatic hydrops (EH). The aim of this study was to compare the results of low-frequency DPOAE (LF-DPOAE) with those of transtympanic electrocochleography (ECoG) in patients with Menière's disease (MD). The prospective study included 50 patients, 22 to 72 years old, who were diagnosed with Menière's disease according to the criteria laid down by the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) in 1995. LF-DPOAE and ECoG were performed on the same day after standard audiometry. Enlarged amplitude of summation potential to action potential ratio was used as the diagnostic criterion for EH. The results were compared to those of LF-DPOAE. In this audiometric examination we used the modulation index (MI) to detect EH if MI < 0.5. ECoG yielded a result in 46 of the 50 patients examined. An enlarged SP/AP ratio was found in 23 patients (50%). The results of 33 patients could be compared, i.e. assessable results in both tests. The two tests yielded the same results in 13 patients and different ones in 20 patients. ROC analysis and Mann-Whitney statistics showed no significant correlation between the two tests. With ECoG as the gold standard for verifying EH, we found that LF-DPOAE is not yet a suitable method for diagnosing EH.
authors.affiliation: Hals-Nasen-Ohrenklinik und Poliklinik Charite, Campus Mitte, Berlin, Germany. andreas.rotter@charite.de
authors.forename: A
authors.initials: A
authors.lastname: Rotter
authors.forename: S
authors.initials: S
authors.lastname: Weikert
authors.forename: J
authors.initials: J
authors.lastname: Hensel
authors.forename: G
authors.initials: G
authors.lastname: Scholz
authors.forename: H
authors.initials: H
authors.lastname: Scherer
authors.forename: M
authors.initials: M
authors.lastname: Hölzl
mesh_terms: D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response / Q000379:methods*; D001301:Audiometry, Pure-Tone / Q000379:methods*; D003937:Diagnosis, Differential; D018159:Endolymphatic Hydrops / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012720:Severity of Illness Index