title: Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv.
abstract: Three xanthones, polyanxanthone A (1), B (2) and C (3) have been isolated from the methanol extract of the wood trunk of Garcinia polyantha, along with five known xanthones: 1,3,5-trihydroxyxanthone (4); 1,5-dihydroxyxanthone (5); 1,3,6,7-tetrahydroxyxanthone (6); 1,6-dihydroxy-5-methoxyxanthone (7) and 1,3,5,6-tetrahydroxyxanthone (8). Their structures were determined by means of 1D- and 2D-NMR techniques. Some of the above compounds were screened for their anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
authors.forename: Gabin Nselapi
authors.initials: GN
authors.lastname: Louh
authors.forename: Alain Meli
authors.initials: AM
authors.lastname: Lannang
authors.forename: Celine Djama
authors.initials: CD
authors.lastname: Mbazoa
authors.forename: Jean Gustave
authors.initials: JG
authors.lastname: Tangmouo
authors.forename: Justin
authors.initials: J
authors.lastname: Komguem
authors.forename: Paula
authors.initials: P
authors.lastname: Castilho
authors.forename: Fernande Ngounou
authors.initials: FN
authors.lastname: Ngninzeko
authors.forename: Naz
authors.initials: N
authors.lastname: Qamar
authors.forename: David
authors.initials: D
authors.lastname: Lontsi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Beiban Luc
authors.initials: BL
authors.lastname: Sondengam
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014934:Wood / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D044004:Xanthones; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase