title: Assessment of global left and right ventricular function using dual-source computed tomography (DSCT) in comparison to MRI: an experimental study in a porcine model.
abstract: OBJECTIVE
  We sought to evaluate the ability of retrospectively ECG-gated dual-source computed tomography (DSCT) to assess left (LV) and right ventricular (RV) functional parameters in comparison to 1.5 T magnetic resonance imaging (MRI).
  
  
  METHODS
  Ten domestic pigs (60 kg) underwent both contrast-enhanced cardiac DSCT and cardiac MRI using standardized examination protocols under general anesthesia. From manually drawn endocardial and epicardial contours, LV and RV end-systolic (ESV) and end-diastolic volume (EDV), stroke volume (SV), ejection fraction (EF), myocardial mass (MM), peak filling rate (PFR), peak ejection rate (PER), time to peak ejection (TPE), and time to peak filling (TPF) were calculated by means of dedicated analysis software. LV and RV functional parameters were analyzed using Bland-Altman plots, Student t test, and Pearson's correlation coefficient.
  
  
  RESULTS
  Both left and right ESV and EDV, SV and EF determined with DSCT correlated well with MR imaging results (left, r = 0.98/0.92/0.82/0.98; right, r = 0.90/0.94/0.96/0.94). PER, PFR, TPE, TPF, and MM showed only a moderate to low correlation (left, r = 0.67/0.37/0.23/0.35/0.57; right, r = 0.78/0.69/0.12/0.11/0.44). PER and PFR were significantly underestimated by DSCT when compared with MRI.
  
  
  CONCLUSIONS
  Retrospectively ECG-gated DSCT correctly depicts end-systole and can accurately determine LV and RV volumes, SV, and EF in comparison to MRI. DSCT showed a significant underestimation of PER and PFR in comparison to MRI.
authors.affiliation: Applied Medical Engineering, Helmholtz-Institute for Biomedical Engineering, Aachen, Germany. bruners@hia.rwth-aachen.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Bruners
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Mahnken
authors.forename: Christian
authors.initials: C
authors.lastname: Knackstedt
authors.forename: Nadja
authors.initials: N
authors.lastname: Luhmann
authors.forename: Elmar
authors.initials: E
authors.lastname: Spüntrup
authors.forename: Marco
authors.initials: M
authors.lastname: Das
authors.forename: Christian
authors.initials: C
authors.lastname: Hohl
authors.forename: Joachim E
authors.initials: JE
authors.lastname: Wildberger
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: Rolf W
authors.initials: RW
authors.lastname: Günther
authors.forename: Georg
authors.initials: G
authors.lastname: Mühlenbruch
mesh_terms: D000818:Animals; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*