title: Topical use of platelet-rich plasma to influence bone volume in maxillary augmentation: a prospective randomized trial.
abstract: OBJECTIVE
  The atrophic posterior maxilla often requires restoration of the alveolar ridge due to a lack of bone quantity and quality before dental implant placement. The aim of this study was to verify the hypothesis that platelet-rich plasma (PRP) has an influence on bone density in the maxilla after sinus floor elevation in combination with autologous cancellous bone from the iliac crest. Therefore, a randomized, prospective, controlled trial was set up in two centres.
  
  
  METHODS
  Fifty-three patients who underwent osteoplastic bone grafting for sinus floor elevation were included. The intervention group was treated with defined concentrations of PRP in addition to transplanted bone. Bone biopsy was performed 4 months after augmentation. Bone volume was then measured using the histomorphometric parameter bone volume.
  
  
  RESULTS
  The histomorphometric evaluation of the biopsies did not indicate superiority of any of the treatments in terms of bone volume.
  
  
  CONCLUSIONS
  Topical use of PRP did not improve maxillary bone volume either clinically relevant or statistically significant compared to that in conventionally treated patients. The use of PRP to support bone regeneration cannot be recommended as a standard method for maxillary augmentation.
authors.affiliation: Department of Maxillofacial Surgery, University of Giessen, Giessen, Germany. heidrun.schaaf@chiru.med.uni-giessen.de
authors.forename: H
authors.initials: H
authors.lastname: Schaaf
authors.forename: P
authors.initials: P
authors.lastname: Streckbein
authors.forename: S
authors.initials: S
authors.lastname: Lendeckel
authors.forename: K
authors.initials: K
authors.lastname: Heidinger
authors.forename: B
authors.initials: B
authors.lastname: Görtz
authors.forename: G
authors.initials: G
authors.lastname: Bein
authors.forename: R-H
authors.initials: RH
authors.lastname: Boedeker
authors.forename: K A
authors.initials: KA
authors.lastname: Schlegel
authors.forename: H-P
authors.initials: HP
authors.lastname: Howaldt
mesh_terms: D000287:Administration, Topical; D001861:Bone Regeneration; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D006801:Humans; D021621:Imaging, Three-Dimensional; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D014182:Transplantation, Autologous
chemical_list: D015921:Dental Implants