[Acetaminophen: hepatotoxicity at therapeutic doses and risk factors].
Although used widely and recognized as a safe drug at therapeutic dose, acetaminophen has a narrow therapeutic margin. Its hepatotoxic potential differs for each individual and depends essentially on associated risk factors which could lead to a severe hepatotoxicity even at therapeutic doses. A systematic screening of these risk factors is essential for an accurate risk stratification and selection of the most adapted treatment strategy. In this article, we review the principal risk factors and propose an approach to aminotranferase elevation in patients using acetaminophen.
Seirafi
M
M
Service de Médecine Interne Générale, Département de Médecine, HUG, Genève. mariam.seirafi@hcuge.ch
Iten
A
A
Hadengue
A
A
D000082:Acetaminophen / Q000009:adverse effects* / Q000493:pharmacokinetics; D000428:Alcohol Drinking; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000493:pharmacokinetics; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control; D012307:Risk Factors
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen