title: Prostate cancer computer-assisted diagnosis software using dynamic contrast-enhanced MRI.
abstract: ProCAD is a computer assisted diagnosis (CAD) software dedicated to prostate DCE-MRI analysis.
  
  
  METHODS
  In addition to standard visualization features, 2D and multislice 2D contouring tools based on a seeded growing region algorithm were included in the software. Tumor volume assessment and semiquantitative analysis of suspicious lesions can be performed. A 5-levels cancer suspicion score (ranging from "probably benign" to "Highly suspicious" is calculated on the basis of adjusted parameters extracted from the data of 121 suspicious benign or tumoral lesions.
  
  
  RESULTS
  Using a simple scoring algorithm based the median w.i and w.o values of TZK, TZB, PZK and PZB and designed to provide the highest sensitivity we had respective Se/Sp of 100/49% for peripheral zone cancers, and 100/40% for transition zone cancers characterization.
  
  
  CONCLUSIONS
  This software provides useful data for an unbiased an reproducible assessment of hypervascularized prostatic areas in routine practice.
authors.affiliation: Inserm, U703 of Lille, France. puech@dicomworks.com
authors.forename: Philippe
authors.initials: P
authors.lastname: Puech
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.forename: Romain
authors.initials: R
authors.lastname: Viard
authors.forename: Arnauld
authors.initials: A
authors.lastname: Villers
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Laurent
authors.initials: L
authors.lastname: Lemaitre
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D016247:Information Storage and Retrieval / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D012985:Software Design; D014584:User-Computer Interface
chemical_list: D003287:Contrast Media