title: CT-perfusion imaging of the human brain: advanced deconvolution analysis using circulant singular value decomposition.
abstract: According to indicator dilution theory tissue time-concentration curves have to be deconvolved with arterial input curves in order to get valid perfusion results. Our aim was to adapt and validate a deconvolution method originating from magnetic resonance techniques and apply it to the calculation of dynamic contrast enhanced computed tomography perfusion imaging. The application of a block-circulant matrix approach for singular value decomposition renders the analysis independent of tracer arrival time to improve the results.
authors.affiliation: Institute of Diagnostic Radiology, University of Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany. wittsack@uni-duesseldorf.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Wittsack
authors.forename: A M
authors.initials: AM
authors.lastname: Wohlschläger
authors.forename: E K
authors.initials: EK
authors.lastname: Ritzl
authors.forename: R
authors.initials: R
authors.lastname: Kleiser
authors.forename: M
authors.initials: M
authors.lastname: Cohnen
authors.forename: R J
authors.initials: RJ
authors.lastname: Seitz
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D004395:Dye Dilution Technique; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D010477:Perfusion; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media