MicroRNAs in the pathogeny of chronic lymphocytic leukaemia.
MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.
Nicoloso
Milena S
MS
Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Kipps
Thomas J
TJ
Croce
Carlo M
CM
Calin
George A
GA
D000818:Animals; D004195:Disease Models, Animal; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics*
D035683:MicroRNAs; D012334:RNA, Neoplasm