Melanoma simulating atypical fibroxanthoma.
Melanoma may present with a wide variety of clinicopathological presentations, among those very rarely lesions imitating atypical fibroxanthoma (AFX). While AFX usually is cured by complete excision, melanoma simulating AFX has a much more serious prognosis, and thus is important to be recognized correctly. The present series describes 4 cases of such melanomas in 3 patients whose exact diagnosis was (markedly) delayed due to unusual clinicopathological presentations including negative immunohistochemistry for melanocytic markers (S100 protein, MelanA/MART1, HMB45).
Sangüeza
Martin
M
Department of Pathology, Hospital Obrero Nro 1, Caja Nacional De Salud, La Paz, Bolivia.
Zelger
Bernhard
B
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D017809:Fatal Outcome; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery
D014408:Biomarkers, Tumor