Characterization of proteomic and metabolomic responses to dietary factors and supplements.
Over the past decade there has been a renewed interest in research and development of both dietary and nutritional supplements. Significant advancements have been made in the scientific assessment of the quality, safety, and efficacy of these products because of the strong interest in and financial support of these projects. As research in both fields continues to advance, opportunities to use new and innovative research technologies and methodologies, such as proteomics and metabolomics, are critical for the future progress of the science. The purpose of the symposium was to begin the process of communicating new innovative proteomic and metabolomic methodologies that may be applied by researchers in both the nutrition and the natural product communities. This symposium highlighted 2 proteomic approaches, protein fingerprinting in complex mixtures with peptoid microarrays and top-down mass spectrometry for annotation of gene products. Likewise, an overview of the methodologies used in metabolomic profiling of natural products was presented, and an illustration of an integrated metabolomics approach in nutrition research was highlighted.
Astle
John
J
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Ferguson
Jonathan T
JT
German
J Bruce
JB
Harrigan
George G
GG
Kelleher
Neil L
NL
Kodadek
Thomas
T
Parks
Bryan A
BA
Roth
Michael J
MJ
Singletary
Keith W
KW
Wenger
Craig D
CD
Mahady
Gail B
GB
D000328:Adult; D001688:Biological Products; D015415:Biomarkers; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D052756:Nutritional Sciences / Q000639:trends; D010449:Peptide Mapping; D011110:Polymorphism, Genetic; D040901:Proteomics / Q000379:methods*
D001688:Biological Products; D015415:Biomarkers