Poly[3-(3,4-dihydroxyphenyl)glyceric acid], a new biologically active polymer from Symphytum asperum Lepech. and S. caucasicum Bieb. (Boraginaceae).
Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], according to IR and NMR spectroscopy. The Symphytum high-molecular preparations can modulate in vitro B- chronic lymphocytic leukaemia (B-CLL) cells apoptosis and cell cycle progression.
Barbakadze
Vakhtang
V
Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences, Georgia. v_barbakadze@hotmail.com
Kemertelidze
Etheri
E
Targamadze
Iraida
I
Mulkijanyan
Karen
K
Shashkov
Alexander S
AS
Usov
Anatolii I
AI
D001704:Biopolymers / Q000737:chemistry / Q000302:isolation & purification; D028082:Boraginaceae / Q000737:chemistry*; D002247:Carbon Isotopes; D002460:Cell Line; D005988:Glyceric Acids / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
D001704:Biopolymers; D002247:Carbon Isotopes; D005988:Glyceric Acids; D011522:Protons; C525096:poly(3-(3,4-dihydroxyphenyl)glyceric acid); C042971:glyceric acid