title: Operative indications for lung cancer with idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, surgical morbidity and mortality in lung cancer patients with IPF remains unclear.
  
  
  METHODS
  The data of patients who underwent surgery for non-small cell lung cancer were retrospectively reviewed.
  
  
  RESULTS
  Of the 1063 patients with lung cancer, 33 (3.1 %) had IPF. Patients with IPF had significantly higher postoperative pulmonary morbidity and mortality than those without IPF (33.3 vs. 2.0 %; 18.2 vs. 1.3 %, respectively, P < 0.0001). Patients with IPF had a significantly higher incidence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than those without IPF (27.3 vs. 1.3 %, P < 0.0001). IPF patients with postoperative ALI/ARDS had a significantly lower preoperative %FVC than those without postoperative ALI/ARDS (74 +/- 9 vs. 103 +/- 14 %, P < 0.0001).
  
  
  CONCLUSIONS
  Lung cancer patients with IPF who have a low preoperative %FVC should be carefully assessed prior to any surgical intervention.
authors.affiliation: Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan. n-thorac@m3.kcn.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Kushibe
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: M
authors.initials: M
authors.lastname: Takahama
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Tojo
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000453:epidemiology / Q000601:surgery; D003657:Decision Making; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D011013:Pneumonectomy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends