Selective antitumor activity of lymphokine-activated killer cells in vitro.
We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).
Zhukova
O S
OS
Laboratory of Cell-Mediated Immunity, N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
Lebedinskaya
O V
OV
Shubina
I Zh
IZh
Gerasimova
G K
GK
Karamzin
A M
AM
Kiselevskii
M V
MV
D002460:Cell Line; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D006801:Humans; D016130:Immunophenotyping; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology