title: Mathematical models for somite formation.
abstract: Somitogenesis is the process of division of the anterior-posterior vertebrate embryonic axis into similar morphological units known as somites. These segments generate the prepattern which guides formation of the vertebrae, ribs and other associated features of the body trunk. In this work, we review and discuss a series of mathematical models which account for different stages of somite formation. We begin by presenting current experimental information and mechanisms explaining somite formation, highlighting features which will be included in the models. For each model we outline the mathematical basis, show results of numerical simulations, discuss their successes and shortcomings and avenues for future exploration. We conclude with a brief discussion of the state of modeling in the field and current challenges which need to be overcome in order to further our understanding in this area.
authors.affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St. Giles, Oxford OX1 3LB, United Kingdom.
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Baker
authors.forename: Santiago
authors.initials: S
authors.lastname: Schnell
authors.forename: Philip K
authors.initials: PK
authors.lastname: Maini
mesh_terms: D000818:Animals; D019521:Body Patterning; D002448:Cell Adhesion; D051524:Fibroblast Growth Factor 8 / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008433:Mathematics; D008954:Models, Biological; D019170:Somites / Q000196:embryology*
chemical_list: D051524:Fibroblast Growth Factor 8