title: Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.
abstract: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.
authors.forename: Andrica C H
authors.initials: AC
authors.lastname: de Vries
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Stam
authors.forename: Christian P
authors.initials: CP
authors.lastname: Kratz
authors.forename: Martin
authors.initials: M
authors.lastname: Zenker
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Niemeyer
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
mesh_terms: D002648:Child; D004252:DNA Mutational Analysis; D006801:Humans; D054429:Leukemia, Myelomonocytic, Juvenile / Q000209:etiology / Q000235:genetics*; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf