title: Dipeptidyl peptidase IV (DDP IV) in NASH patients.
abstract: OBJECTIVE
  Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with unknown etiology. The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions. This study aimed to elicudate the changes related to DPPIV in NASH patients.
  
  
  METHODS
  Serum and urinary DPPIV activities were measured in 31 NASH patients and 17 healthy controls. The liver biopsies of 29 patients were immunolabeled for CD26.
  
  
  RESULTS
  The mean age of patients were 46 +/- 11 years and 14 (45%) of them were female. The serum DPPIV activity was higher in patients (57.3 +/- 7.8 U/L) than controls (43.6 +/- 10.6 U/L) (p < 0.0001), and correlated with the histopathological grade (p = 0.038, r = 0.373) and hepatosteatosis (p = 0.018, r = 0.423) but not with stage (p = 0.286), class (p = 0.286) or CD26 staining (p = 0.743). The urinary DPPIV activity was similar in patients (1.52 +/- 0.94 U/mmol creatinine) and controls (1.37 +/- 0.68 U/mmol creatinine) (p = 0.861). Three acinar zones of liver had equal CD26 expression (p = 0.076). The intensity of CD26 immunostaining was correlated with histopathological grade (p = 0.001) and hepatosteatosis (p = 0.003) but no correlation with stage or class could be detected (p = 0.610 and 0.956, respectively). In
  
  
  CONCLUSIONS
  The serum DPPIV activity and the staining intensity of CD26 in liver are correlated with histopathologic grade of NASH and hepatosteatosis. DPPIV can be proposed as a novel candidate with several potential functions in NASH pathogenesis.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Abant Izzet Baysal University, Bolu - Turkey. ybalaban@superonline.com
authors.forename: Yasemin H
authors.initials: YH
authors.lastname: Balaban
authors.forename: Petek
authors.initials: P
authors.lastname: Korkusuz
authors.forename: Halis
authors.initials: H
authors.lastname: Simsek
authors.forename: Hale
authors.initials: H
authors.lastname: Gokcan
authors.forename: Gokhan
authors.initials: G
authors.lastname: Gedikoglu
authors.forename: Asli
authors.initials: A
authors.lastname: Pinar
authors.forename: Gulsen
authors.initials: G
authors.lastname: Hascelik
authors.forename: Esin
authors.initials: E
authors.lastname: Asan
authors.forename: Erhan
authors.initials: E
authors.lastname: Hamaloglu
authors.forename: Gonca
authors.initials: G
authors.lastname: Tatar
mesh_terms: D000328:Adult; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000652:urine*; D005234:Fatty Liver / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D018819:Dipeptidyl Peptidase 4