title: Baclofen as prophylaxis and treatment for alcohol withdrawal: a retrospective chart review.
abstract: BACKGROUND
  Current standard of care for alcohol withdrawal is accomplished using benzodiazepines. There are no recommendations for prophylaxis of alcohol withdrawal in high risk populations. Baclofen has been studied for the treatment of alcohol withdrawal, but current research is limited.
  
  
  OBJECTIVE
  To determine if baclofen is an effective measure for prophylaxis and treatment of alcohol withdrawal in high risk populations upon admission to hospital wards. Design, Setting, Patients - Retrospective chart review of 42 inpatients at St. Anthony Hospital from November 2004 to April 2005. Patients were included if they were determined to be at risk for alcohol withdrawal. Patients were then divided into categories of prophylactic success versus failure and treatement success versus failure based on DSM-IV criteria for alcohol withdrawal.
  
  
  RESULTS
  17 patients were included in the study. 12 were categorized as prophylactic success and 2 were categorized as prophylactic failure. There was one treatment success and two treatment failures. The result was an 86% prophylactic success rate.
  
  
  CONCLUSIONS
  Baclofen has potential in the prophylaxis of alcohol withdrawal. It is difficult to determine the clinical significance for the numbers found in this study. There are no prior studies for alcohol prophylaxis to compare what would be an acceptable success rate. Further studies that are double-blinded placebo controlled are needed to support or refute the usefulness of baclofen for alcohol withdrawal.
authors.affiliation: St. Anthony Family Practice Residency, 608 NW 9th Suite 1000, Oklahoma City, OK 73102, USA. William_stallings_md@ssmhc.com
authors.forename: William
authors.initials: W
authors.lastname: Stallings
authors.forename: Stuart
authors.initials: S
authors.lastname: Schrader
mesh_terms: D000437:Alcoholism / Q000534:rehabilitation*; D001418:Baclofen / Q000627:therapeutic use*; D006801:Humans; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D001418:Baclofen