Structure-activity relationships for the 9-(pyridin-2'-yl)- aminoacridines.
A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
Mosher
Michael D
MD
Department of Chemistry, University of Nebraska at Kearney, 905 W. 25th St., Kearney, Nebraska 68849-1150, USA. mosherm@unk.edu
Holmes
Kristi L
KL
Frost
Katherine S
KS
D000609:Aminoacridines / Q000138:chemical synthesis / Q000737:chemistry*; D000677:Amsacrine / Q000737:chemistry; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D009691:Nucleic Acid Denaturation; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship; D011796:Quinacrine / Q000737:chemistry
D000609:Aminoacridines; D018906:Antineoplastic Agents, Alkylating; D011725:Pyridines; D000677:Amsacrine; D004247:DNA; C427203:calf thymus DNA; D011796:Quinacrine