title: Impact of chronic hepatitis C and/or D on liver fibrosis severity in patients co-infected with HIV and hepatitis B virus.
abstract: The histological study on the reciprocal influence of chronic hepatitis C (HCV) and/or delta (HDV) on liver damage in a cohort of 134 HIV-HBV co-infected patients concluded on a significant association between HDV co-infection (noted in 13 patients) and Metavir F3-F4 liver fibrosis score [odds ratio (OR) = 7.08, 95% confidence interval (CI) = 1.06-47.28 for HBV-HDV, OR = 10.02, 95% CI = 1.03-97.42 for HBV-HCV-HDV, compared to OR = 1.76, 95% CI = 0.50-6.17 for HBV alone]. Co-treatment of other multiple viral hepatitis infections should also be taken into consideration, especially in the case of chronic HDV.
authors.affiliation: Inserm, UMR S707, Paris, F-75012, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Lacombe
authors.forename: Anders
authors.initials: A
authors.lastname: Boyd
authors.forename: Moise
authors.initials: M
authors.lastname: Desvarieux
authors.forename: Lawrence
authors.initials: L
authors.lastname: Serfaty
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonnord
authors.forename: Joel
authors.initials: J
authors.lastname: Gozlan
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.forename: Patrick
authors.initials: P
authors.lastname: Miailhes
authors.forename: Caroline
authors.initials: C
authors.lastname: Lascoux-Combe
authors.forename: Elyanne
authors.initials: E
authors.lastname: Gault
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D019701:Hepatitis D, Chronic / Q000150:complications; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index