New multi-1,2,3-selenadiazole aromatic derivatives.
The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the corresponding semicarbazones derivatives 4a-d or hydrazones 5a-d. The reaction with selenium dioxide leads to regiospecific ring closure of semicarbazones or hydrazones to give the multi- 1,2,3-selenadiazole aromatic derivatives in high yield.
Al-Smadi
Mousa
M
Department of Applied Chemical Sciences, Jordan University of Science and Technology, Jordan. mariam10@just.edu.jo
Ratrout
Samer
S
D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D001393:Azoles; D018036:Selenium Compounds