Parental history of type 2 diabetes in patients with nonaffective psychosis.
BACKGROUND
We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands.


METHODS
N=34 patients with newly-diagnosed nonaffective psychosis and N=52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes.


RESULTS
In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p<0.04).


CONCLUSIONS
We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.
Fernandez-Egea
Emilio
E
Programa Esquizofrenia Clinic, Servel de Psiquiatria, Institut de Neurociencies, Hospital Clinic, Department de Psiquiatria, Universitat de Barcelona, Barcelona, Spain.
Miller
Brian
B
Bernardo
Miguel
M
Donner
Thomas
T
Kirkpatrick
Brian
B
D000328:Adult; D002648:Child; D016241:Child of Impaired Parents; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D015233:Models, Statistical; D010290:Parents / Q000523:psychology*; D010331:Paternal Age; D015995:Prevalence; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics; D012565:Schizophrenic Psychology; D012931:Social Environment