[The expression and significance of ERK1, ERK2 gene in tongue squamous cell carcinoma].
OBJECTIVE
The aim of this study is to investigate the relationship between ERK1, ERK2 gene expression and tumor behavior such as invasion, metastasis in tongue squamous cell carcinoma (TSCC).


METHODS
The expressions of ERK1, ERK2 at gene level were examined in 45 cases of TSCC by reverse transcriptase polymerase chain reaction(RT-PCR). Student's t test was used for data analysis using SPSS 12.0 software package.


RESULTS
No correlation between the expression intensity of ERK gene and tumor pathological degree of TSCC.A significant relationship was observed between the expression intensity of ERK gene and T stage of TSCC. A significant relationship was observed between the expression intensity of ERK gene and lymphnode metastasis of TSCC.


CONCLUSIONS
Activation of ERK gene may play a strong role in cervical lymph node metastasis of TSCC. Intensive expression of ERK may be an important presage marker in TSCC patient. Supported by Key Science and Technology Research Project of Liaoning Province (Grant No.2005225013-2).
Wang
Tian-xiang
TX
Dental Department of Daqing Youtian Hospital, Daqing 163001, China.
Zheng
Wen-ju
WJ
Wang
Qiu-xu
QX
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014062:Tongue Neoplasms / Q000378:metabolism*
C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3