title: Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient.
abstract: Between 2000 and 2004, dengue virus type 1 (DENV-1) genotypes I and II from Asia were introduced into the Pacific region and co-circulated in some localities. Envelope protein gene sequences of DENV-1 from 12 patients infected on the island of New Caledonia were obtained, five of which carried genotype I viruses and six, genotype II viruses. One patient harboured a mixed infection, containing viruses assigned to both genotypes I and II, as well as a number of inter-genotypic recombinants. This is the first report of a population of dengue viruses isolated from a patient containing both parental and recombinant viruses.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Aaskov
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: Katie
authors.initials: K
authors.lastname: Buzacott
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Field
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: Kym
authors.initials: K
authors.lastname: Lowry
authors.affiliation: Institute Pasteur, Noumea, New Caledonia.
authors.forename: Alain
authors.initials: A
authors.lastname: Berlioz-Arthaud
authors.affiliation: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.|Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Holmes
mesh_terms: D000818:Animals; D002460:Cell Line; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000235:genetics*; D004196:Disease Outbreaks; D006801:Humans; D017720:Molecular Epidemiology; D009510:New Caledonia / Q000453:epidemiology; D010802:Phylogeny; D011995:Recombination, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus