title: Catalytic enantioselective approach to the stereodivergent synthesis of (+)-lasubines I and II.
abstract: A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I and II is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asymmetric formal aza-Diels-Alder reaction between N-tosyl aldimines and Danishefsky's diene.
authors.affiliation: Departamento de Química OrgAnica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Olga García
authors.initials: OG
authors.lastname: Mancheño
authors.forename: Ramón Gómez
authors.initials: RG
authors.lastname: Arrayas
authors.forename: Javier
authors.initials: J
authors.lastname: Adrio
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero
mesh_terms: D002384:Catalysis; D008968:Molecular Conformation; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011807:Quinolizines; C414385:lasubin I