An increase in HbA1c after percutaneous coronary intervention raises the risk for restenosis in patients without Type 2 diabetes mellitus.
OBJECTIVE
The influence of dynamic changes in glycated haemoglobin (HbA(1c)) on restenosis after elective percutaneous coronary intervention (PCI) in patients without diabetes has not been analysed. Therefore, the rate of restenosis was investigated after elective PCI in 101 consecutive patients without diabetes mellitus in relation to dynamic changes of HbA(1c) levels.


METHODS
Follow-up angiography was performed in all patients 4-6 months after intervention.


RESULTS
Multivariate analysis demonstrated that the change in HbA(1c) between first and second coronary angiography was the most powerful metabolic parameter for prediction of restenosis. The odds ratio for restenosis was 3.0 (95% CI 1.0-9.0) for any increase in HbA(1c) and 1.9 (95% CI 1.1-3.5) for an HbA(1c) increase of 0.2%.


CONCLUSIONS
Hence, chronic changes in the glucometabolic environment influence the incidence of restenosis after PCI in patients without diabetes.
Diedrichs
H
H
Clinic III for Internal Medicine, University of Köln, Cologne, Germany. Holger.Diedrichs@uni-koeln.de
Pfister
R
R
Hagemeister
J
J
Müller-Ehmsen
J
J
Frank
K F
KF
Höpp
H-W
HW
Erdmann
E
E
Schneider
C A
CA
D015906:Angioplasty, Balloon, Coronary; D001786:Blood Glucose / Q000378:metabolism; D023903:Coronary Restenosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents
D001786:Blood Glucose; D006442:Glycated Hemoglobin