Comparative studies of the effects of two novel sugar drug candidates on the CYP 1A2 and CYP 2E1 enzymes in different sexed rats using a "cocktail" approach.
The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.
Shi
Jie
J
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China.
Geng
Mei-Yu
MY
Liu
Chang-Xiao
CX
D000818:Animals; D002110:Caffeine / Q000493:pharmacokinetics; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics; D002753:Chlorzoxazone / Q000493:pharmacokinetics; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics; D011134:Polysaccharides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors
D000697:Central Nervous System Stimulants; D008351:Mannans; D009125:Muscle Relaxants, Central; D011134:Polysaccharides; C500727:acidic oligosaccharide sugar chain, Echlonia Kurome Okam; C489185:sulfated polymannuroguluronate; D002110:Caffeine; D019392:Cytochrome P-450 CYP2E1; D019388:Cytochrome P-450 CYP1A2; D002753:Chlorzoxazone