title: Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components.
abstract: Gangliogliomas are rare CNS neoplasms mostly occuring in young adults and are usually assigned to WHO grade I. The few cases of WHO grade IV gangliogliomas were either primarily malignant glio-neuronal tumors or underwent malignant progression from other WHO grades after radiotherapy. Herein, we present the case of a now 47-year-old female patient presenting with a benign ganglioglioma and showing a tumor recurrence 2 years later with an anaplastic ganglioglioma, assigned to WHO grade IV, with malignant transformation in both glial and neuronal components. The presented case is the first reported low-grade ganglioglioma rapidly progressing to a WHO grade IV glio-neuronal tumor not being associated with radiotherapy and showing malignant transformation in both astroglial and neuronal tumor cell components.
authors.affiliation: Institute of Brain Research, University of Tuebingen, Tuebingen, Germany. michel.mittelbronn@usz.ch
authors.forename: Michel
authors.initials: M
authors.lastname: Mittelbronn
authors.forename: Jens
authors.initials: J
authors.lastname: Schittenhelm
authors.forename: Dieter
authors.initials: D
authors.lastname: Lemke
authors.forename: Rainer
authors.initials: R
authors.lastname: Ritz
authors.forename: Thomas
authors.initials: T
authors.lastname: Nägele
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
authors.forename: Richard
authors.initials: R
authors.lastname: Meyermann
authors.forename: Rudi
authors.initials: R
authors.lastname: Beschorner
mesh_terms: D001253:Astrocytes / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003071:Cognition; D018450:Disease Progression; D005260:Female; D018303:Ganglioglioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D016896:Treatment Outcome