A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation.
A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50 degrees C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
Ouyang
Guiping
G
Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
Song
Baoan
B
Zhang
Huiping
H
Yang
Song
S
Jin
Linhong
L
Li
Qianzhu
Q
Hu
Deyu
D
D000631:Aminopyridines / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D003487:Cyanoacrylates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000528:radiation effects*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008872:Microwaves; D008954:Models, Biological; D014407:Tumor Cells, Cultured
D000631:Aminopyridines; D000814:Aniline Compounds; D000970:Antineoplastic Agents; D003487:Cyanoacrylates; C487557:4-trifluoromethylaniline