Orchestration of dysregulated epithelial turnover by a manipulative pathogen.
Chronic Helicobacter pylori infection is the strongest known risk factor for the development of gastric cancer. In order to survive and propagate under the harsh conditions of the gastric niche, this pathogen has evolved numerous means to interact with host epithelium. In this issue, Mimuro et al. shed light on mechanisms by which Helicobacter pylori attenuates apoptosis in the gastric epithelium to facilitate its persistence within the human stomach.
Wroblewski
Lydia E
LE
Department of Medicine, Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Peek
Richard M
RM
D017209:Apoptosis; D002908:Chronic Disease; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000502:physiology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology