[Remifentanil in general anesthesia].
Remifentanil is a potent mu-opioid receptor agonist and has some unique pharmacokinetic characteristics compared with fentanyl. Properties of remifentanil such as rapid onset of action, easy titration of concentration and quick emergence even after a long duration of anesthesia with high doses may produce analgesia strong enough to keep patients free from surgical stresses during general anesthesia. Understanding its pharmacological advantages and some experiences will provide better care for our patients. Analgesia-oriented opioid-based anesthesia with remifentanil will become a new trend that may significantly alter our anesthesia practice.
Makita
Koshi
K
Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000768:Anesthesia, General / Q000639:trends*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D006801:Humans; D010880:Piperidines / Q000494:pharmacology*; D000077208:Remifentanil
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil