Associations of isoprostanes-related oxidative stress with surrogate subclinical indices and angiographic measures of atherosclerosis.
OBJECTIVE
Cardiovascular diseases are the most common cause of death in the world. Oxidative stress has been proved to play a role in atherosclerotic diseases and 8-isoprostane is one of the most valid markers of in-vivo oxidative stress. We aimed to investigate the 8-isoprostane levels in relation to surrogate and direct angiographic indexes of atherosclerosis.


METHODS
Urinary 8-isoprostane levels were measured and a B-mode carotid ultrasound examination was performed in 100 consecutive patients scheduled for coronary angiography.


RESULTS
In patients with angiographic coronary artery disease (CAD) urinary 8-isoprostane levels were significantly (P<0.001) higher than in patients without CAD (68.75+/-5.5 vs. 38.27+/-3.7 pg/ml). Moreover, 8-isoprostane levels of patients with increased carotid intima media thickness (CIMT) were higher (P<0.001) than in patients with normal CIMT values (75.12+/-6.4 vs. 38.72+/-2.7 pg/ml). Moreover log(8-isoprostane) levels were significantly correlated with maximum and mean CIMT values (P<0.001) and across univessel and multivessel CAD groups levels of log(8-isoprostane) showed a significantly (P<0.001) increasing trend. Logistic regression analysis revealed that 8-isoprostane levels were an independent predictor for both intima-media thickening and angiographic CAD.


CONCLUSIONS
These findings indicate that elevated urinary levels of 8-isoprostane are associated with both subclinical atherosclerosis and manifest CAD. The results therefore support the hypothesis that isoprostanes-related oxidative stress is involved in the whole atherosclerotic process.
Basarici
Ibrahim
I
Akdeniz University School of Medicine, Department of Cardiology, Antalya, Turkey. ibasarici@akdeniz.edu.tr
Altekin
Refik Emre
RE
Demir
Ibrahim
I
Yilmaz
Huseyin
H
D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017023:Coronary Angiography; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000502:physiology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014463:Ultrasonography
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost