Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include the following: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling, and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease, and cystic fibrosis.
Panettieri
Reynold A
RA
Airway Biology and Disease Program, Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10042, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892-7952, USA.
Kotlikoff
Michael I
MI
Gerthoffer
William T
WT
Hershenson
Marc B
MB
Woodruff
Prescott G
PG
Hall
Ian P
IP
Banks-Schlegel
Susan
S
D000199:Actins / Q000502:physiology; D016084:Bronchoconstriction / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009130:Muscle, Smooth / Q000276:immunology / Q000502:physiology; D054555:National Heart, Lung, and Blood Institute (U.S.); D012137:Respiratory System / Q000254:growth & development / Q000276:immunology / Q000503:physiopathology; D014481:United States
D000199:Actins