title: [The relationship between cbfalpha1 and the mechanism of the bone remodeling in the process of orthodontic tooth movement].
abstract: OBJECTIVE
  To perform qualitative and quantitative analyses of core binding factor alpha1 (cbfalpha1) in periodontal tissue during the experimental rat tooth movement process and to investigate the active mechanism of cbfalpha1 in the osteoblast differentiation.
  
  
  METHODS
  42 male Wistar rats aged 8 weeks were divided into 7 groups (0,1,3,5,7,10 and 14 days groups) in random, 6 rats in each group. 42 rats were perfused and sacrificed at the 1st, 3rd, 5th, 7th, 10th and 14th day. All specimens were fixed, then proceeded with HE and cbfalpha1 immunohistochemical staining. The results were analyzed by SPSS11.0 software package for Dunnett test, and the histological changes of cbfalpha1 in periodontal tissue were evaluated.
  
  
  RESULTS
  In the periodontal ligament(PDL) of non orthodontic treatment group, the expression of cbfalpha1 was lower; the expression of cbfalpha1 in every experimental groups increased firstly and decreased later; the expression of cbfalpha1 in the surface of the alveolar bone was lower in the compression side than in the tension side, and the number of positive cells was less too (P<0.01).
  
  
  CONCLUSIONS
  cbfalpha1 participates in the process of bone remodeling during the process of orthodontic tooth movement, and it promotes the remodeling and stability of PDL.
authors.affiliation: Department of Orthodontics,West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Han
authors.initials: H
authors.lastname: Shi
authors.forename: Yuan-ping
authors.initials: YP
authors.lastname: Chen
authors.forename: Rui-xin
authors.initials: RX
authors.lastname: Shi
authors.forename: Guang-hong
authors.initials: GH
authors.lastname: Han
authors.forename: Yang-xi
authors.initials: YX
authors.lastname: Chen
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D050657:Core Binding Factor alpha Subunits / Q000378:metabolism*; D008297:Male; D010010:Osteoclasts; D010513:Periodontal Ligament; D010519:Periodontium; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
chemical_list: D050657:Core Binding Factor alpha Subunits; C406688:core binding factor alpha