title: Comparison of examination of the entire uterine cervix with routine cervical sampling in hysterectomy specimens from women with endometrial cancer.
abstract: BACKGROUND
  Cervical involvement by endometrial cancer alters the FIGO stage and determines clinical management, but there are no accepted guidelines for cervical sampling of these cases.
  
  
  OBJECTIVE
  To assess whether sampling more than two "routine" blocks of the cervix (anterior and posterior) alters the pathological staging of hysterectomy specimens for endometrial cancer.
  
  
  METHODS
  Histological involvement of the cervix was prospectively compared in hysterectomies performed for proven endometrial cancer (n = 61). Specimens had two "routine" blocks taken from anterior and posterior cervix; all of the remaining cervix was also processed for histological assessment.
  
  
  RESULTS
  61 cases of endometrial cancer had the entire uterine cervix processed. There were 54 cases of endometrioid adenocarcinoma and 7 special types. Twelve cases had cervical involvement (stage 2A or 2B), and seven cases were stage 3A or above, of which three also had cervical involvement. In none of the 61 cases did the additional cervical blocks (n = 544) taken alter the staging made on the "routine" blocks.
  
  
  CONCLUSIONS
  Sampling of two blocks from the cervix appears sufficient for histological staging of endometrial cancer in hysterectomy specimens.
authors.affiliation: Department of Cellular Pathology, Queen Elizabeth Hospital, Gateshead, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Nayar
authors.forename: P A
authors.initials: PA
authors.lastname: Cross
authors.forename: J N
authors.initials: JN
authors.lastname: Bulmer
authors.forename: S
authors.initials: S
authors.lastname: Deen
authors.forename: A
authors.initials: A
authors.lastname: El-Sherif
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011446:Prospective Studies; D013048:Specimen Handling / Q000379:methods