Coronin-1A epigenomics governs mycobacterial persistence in tuberculosis.
The lack of innovative therapies and the emergence of multi-drug-resistant pathogens emphasize the urgency of finding new approaches to fighting intracellular pathogens in general and Mycobacterium tuberculosis in particular, especially given the fact that tuberculosis is widely recognized as a major health problem worldwide. This review describes how host phagocytic cellular Coronin-1A gene epigenomics can be used to understand the subversive strategy adopted by M. tuberculosis to avoid encounter with the harsh environment within the phagocytic vacuole, and how it may provide a novel approach for the prevention and treatment of tuberculosis.
Kaul
Deepak
D
Molecular Biology Unit, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dkaul_24@hotmail.com
D002784:Cholesterol / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics* / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D010587:Phagocytosis; D010588:Phagosomes / Q000737:chemistry / Q000382:microbiology / Q000502:physiology; D014376:Tuberculosis / Q000378:metabolism* / Q000517:prevention & control / Q000628:therapy
D008840:Microfilament Proteins; C072061:coronin proteins; D002784:Cholesterol