The effects of sildenafil on heart rate variability in healthy subjects.
The effects of sildenafil on heart rate variability were investigated in 20 healthy male subjects aged 24 (21 to 32) years (median; range). Subjects orally received single 100-mg doses of sildenafil and placebo under randomized double-blind crossover conditions on 2 separate study days. Time domain measures of heart rate variability were assessed under conditions of relaxed rest, metronomic breathing (6 cycles per minute), and bicycle ergometry before administration of sildenafil and placebo as well as 60 minutes afterwards. Sildenafil did not alter heart rate nor heart rate variability to a significant extent (P > 0.05).
Siepmann
Martin
M
Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany. martin.siepmann@.tu-dresden.de
Rauh
Robert
R
Dill
Oliver
O
Agelink
Marcus W
MW
Mueck-Weymann
Michael
M
D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D012119:Respiration; D012146:Rest / Q000502:physiology; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D016683:Supine Position / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate