title: Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: on the significance of the orientation and substitution at position 3.
abstract: The synthesis and structure-activity relationships concerning 3,4,5-trisubstituted 1,2,4-triazoles as ghrelin receptor ligands are described. The importance of the starting aminoacid material as well as its configuration was explored and the (D) Trp residue was found to lead to the best agonist or antagonist compounds.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247, CNRS-Université Montpellier I, BP 14491, Faculté de Pharmacie, 15 avenue Charles Flahault, 34093 Montpellier Cedex 5, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Moulin
authors.forename: Luc
authors.initials: L
authors.lastname: Demange
authors.forename: Joanne
authors.initials: J
authors.lastname: Ryan
authors.forename: Céline
authors.initials: C
authors.lastname: M'Kadmi
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Galleyrand
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Jean-Alain
authors.initials: JA
authors.lastname: Fehrentz
mesh_terms: D008024:Ligands; D054440:Receptors, Ghrelin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D008024:Ligands; D054440:Receptors, Ghrelin; D014230:Triazoles