title: Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.
abstract: Unnatural "L-DNA" containing 2'-deoxy-L-ribose backbone instead of natural 2'-deoxy-D-ribose was synthesized and evaluated by (1)H NMR, CD spectra. Proton ((1)H) NMR spectra of natural DNA (D-TpT) and L-DNA (L-TpT) are fully consistent with each other. In CD spectra, however, spectrum of L-TpT was reversed, relative to that of D-TpT. These results indicate that L-TpT is an isomer with a mirror image configuration of D-TpT. In summary, we have synthesized enantiomeric L-DNA, and the L-DNA would be materials for nanodevices and tools for exploring why the D-isomer of DNA molecules was selected as a bio-molecule.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Kaichiro
authors.initials: K
authors.lastname: Haruta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Takuya
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kondo
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamakoshi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanoh
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Iwabuchi
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013941:Thymine / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides; D004247:DNA; D008628:Mercury; D013941:Thymine