title: A method to detect obstructive sleep apnea using neural network classification of time-frequency plots of the heart rate variability.
abstract: This paper presents a new method of analyzing time-frequency plots of heart rate variability to detect sleep disordered breathing from nocturnal ECG. Data is collected from 12 normal subjects (7 males, 5 females; age 46+/-9.38 years, AHI 3.75+/-3.11) and 14 apneic subjects (8 males, 6 females; age 50.28+/-9.60 years; AHI 31.21+/-23.89). The proposed algorithm uses textural features extracted from normalized gray-level co-occurrence matrices (NGLCM) of images generated by short-time discrete Fourier transform (STDFT) of the HRV. Using feature selection, seventeen features extracted from 10 different NGLCMs representing four characteristically different gray-level images are used as inputs to a three-layer Multi-Layer Perceptron (MLP) classifier. After a 1000 randomized Monte-Carlo simulations, the mean training classification sensitivity, specificity and accuracy are 99.00%, 93.42%, and 96.42%, respectively. The mean testing classification sensitivity, specificity and accuracy are 94.42%, 85.40%, and 90.16%, respectively.
authors.affiliation: Bioengineering Department, University of Texas, Arlington, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Abed
authors.forename: Michael
authors.initials: M
authors.lastname: Manry
authors.forename: John R
authors.initials: JR
authors.lastname: Burk
authors.forename: Edgar A
authors.initials: EA
authors.lastname: Lucas
authors.forename: Khosrow
authors.initials: K
authors.lastname: Behbehani
mesh_terms: D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005103:Expert Systems; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000503:physiopathology*