title: Outcomes in surgical versus medical patients with the secondary abdominal compartment syndrome.
abstract: BACKGROUND
  Secondary abdominal compartment syndrome (SACS) is a well-recognized sequelae of massive fluid resuscitation in surgical patients, but has only anecdotally been reported in the medical patient population. The purpose of this study was to compare the clinical scenarios, physiologic indices, and outcomes of patients with SACS due to medical versus trauma etiologies.
  
  
  METHODS
  Patients undergoing decompression for SACS from January 1999 to January 2006 were identified using our computerized operative records.
  
  
  RESULTS
  During the 7-year study period, 54 patients developed SACS (41 postinjury patients and 13 medical patients). There were no significant differences in demographics, physiologic indices, or fluid resuscitation between the medical and postinjury groups: age (46.6 +/- 4.7 vs 40.6 +/- 2.3), bladder pressure (33.5 +/- 1.1 vs 32.8 +/- 1.8), peak airway pressures (45.9 +/- 2.4 vs 49.3 +/- 2.1), base deficit (14.6 +/- 1.4 vs 13.6 +/- 1.1), and fluids (18.5 +/- 1.8 vs 16.0 +/- 1.5 liters). Patients with a medical cause of SACS had a significantly longer time to decompression (21 +/- 3.6 versus 6.5 +/- 1.9 hours), significantly higher incidence of MOF (62% v 27%), and trend toward greater mortality (54% versus 34%).
  
  
  CONCLUSIONS
  Patients with diverse disease processes may develop SACS. Despite similar age and physiologic indices, the MOF and mortality rates associated with medical SACS are markedly higher. These findings highlight the need for routine monitoring in at-risk patients, prevention of pathologic intra-abdominal hypertension, and a low threshold for decompression.
authors.affiliation: The Department of Surgery, Denver Health Medical Center, 777 Bannock Street, MC 0206, Denver, CO 80204, USA. clay.cothren@dhha.org
authors.forename: C Clay
authors.initials: CC
authors.lastname: Cothren
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Moore
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Johnson
authors.forename: John B
authors.initials: JB
authors.lastname: Moore
mesh_terms: D000005:Abdomen; D000007:Abdominal Injuries / Q000628:therapy; D000328:Adult; D003161:Compartment Syndromes / Q000209:etiology* / Q000601:surgery; D000077324:Crystalloid Solutions; D019299:Decompression, Surgical; D017707:Erythrocyte Transfusion; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D015601:Injury Severity Score; D007552:Isotonic Solutions; D008297:Male; D009102:Multiple Organ Failure / Q000453:epidemiology; D009104:Multiple Trauma / Q000150:complications; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods; D012771:Shock, Hemorrhagic / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions