ALIX catches HIV.
ESCRT and ESCRT-associated proteins are required during the assembly and release of many RNA viruses, including HIV. Two new papers provide structures for the ESCRT-associated protein ALIX/AIP1 and demonstrate how this protein interacts with HIV Gag. One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered.
Martin-Serrano
Juan
J
Department of Infectious Diseases, King's College London School of Medicine, Second Floor, New Guy's House, Guy's Hospital, London SE1 9RT, United Kingdom. juan.martin_serrano@kcl.ac.uk
Marsh
Mark
M
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000378:metabolism; D015683:Gene Products, gag / Q000235:genetics / Q000378:metabolism; D051528:Guanylate Kinases; D006678:HIV / Q000378:metabolism* / Q000648:ultrastructure; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D019065:Virus Assembly
D048868:Adaptor Proteins, Signal Transducing; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; C117020:PDCD6IP protein, human; D011506:Proteins; D051528:Guanylate Kinases; C485777:MAGI2 protein, human