title: Sildenafil may facilitate weaning in mechanically ventilated COPD patients: a report of three cases.
abstract: We report three cases of mechanically ventilated chronic obstructive pulmonary disease patients who were intubated due to an exacerbation of their disease and who presented with repeated spontaneous breathing trial failures. Patients were given 50 mg of sildenafil through the nasogastric tube, under close monitoring of haemodynamic and ventilatory parameters. After sildenafil, pulmonary artery pressure, pulmonary artery occlusion pressure, the respiratory frequency to tidal volume ratio and the P(a)CO2-P(ET)CO2 (arterial minus end-tidal carbon dioxide pressure) decreased. Cardiac output increased in two of the patients, while all of them were successfully extubated. This is the first report of successful extubation after sildenafil use.
authors.affiliation: Respiratory Failure Unit, Aristotle University, G. Papanikolaou Hospital, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Stanopoulos
authors.forename: N
authors.initials: N
authors.lastname: Manolakoglou
authors.forename: G
authors.initials: G
authors.lastname: Pitsiou
authors.forename: I
authors.initials: I
authors.lastname: Trigonis
authors.forename: E A
authors.initials: EA
authors.lastname: Tsiata
authors.forename: A K
authors.initials: AK
authors.lastname: Boutou
authors.forename: P K
authors.initials: PK
authors.lastname: Kontou
authors.forename: P
authors.initials: P
authors.lastname: Argyropoulou
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*; D011687:Purines / Q000627:therapeutic use; D012129:Respiratory Function Tests; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D015300:Ventilator Weaning / Q000379:methods*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate