title: Making oligonucleotide conjugates and breaking oligonucleotides.
abstract: Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups. Recent results on cleavage of RNA by artificial nucleases, is also presented.
authors.affiliation: Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Milton
authors.forename: M
authors.initials: M
authors.lastname: Murtola
authors.forename: J
authors.initials: J
authors.lastname: Sandbrink
authors.forename: E
authors.initials: E
authors.lastname: Yeheskiely
authors.forename: R
authors.initials: R
authors.lastname: Strömberg
mesh_terms: D002219:Carbamates / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry*
chemical_list: D002219:Carbamates; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012260:Ribonucleases