title: Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation.
abstract: Elimination kinetics and tissue disposition of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in male chickens (Gallus gallus) was determined following exposure by subcutaneous implantation. Chickens were exposed to two levels of PFOA or PFOS for 4wk and then allowed to depurate for an additional 4wk. These exposures did not cause any statistically significant changes in body index, clinical biochemistry or histology among treatments relative to the controls (p>0.05), except that concentrations of total cholesterol and phospholipids were less in chickens exposed to PFOS. The elimination rate constant for PFOA (0.150+/-0.010d(-1)) was approximately six-fold greater than that of PFOS (0.023+/-0.004d(-1)). The greatest concentrations of PFOA and PFOS were found in kidney and liver, respectively. The organ to blood ratio of PFOS concentration was increased after the whole experiment, indicating the importance of organ partitioning of PFOS in elimination kinetics. The depuration half-life of PFOA (t(1/2)=4.6d) and PFOS (t(1/2)=125d) in chickens was calculated.
authors.affiliation: National Food Safety and Toxicology Center, Zoology Department and Center for Integrative Toxicology, Michigan State University, East Lansing, 48824, USA; Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Hoon
authors.initials: H
authors.lastname: Yoo
authors.affiliation: Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan. Electronic address: guruge@affrc.go.jp.
authors.forename: Keerthi S
authors.initials: KS
authors.lastname: Guruge
authors.affiliation: Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamanaka
authors.affiliation: Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan; Iwate South Animal Hygiene Service Center, Higashidate 41-1, Sakurakawa, Mizusawa, Oshu, Iwate 023-0003, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sato
authors.affiliation: Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Mikami
authors.affiliation: Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyazaki
authors.affiliation: Potential Pollutants Group, National Institute of Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba, Ibaraki 305-8569, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Yamashita
authors.affiliation: National Food Safety and Toxicology Center, Zoology Department and Center for Integrative Toxicology, Michigan State University, East Lansing, 48824, USA; Department of Biomedical and Veterinary Biosciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Biology and Chemistry Department, City University of Hong Kong, Kowloon, Hong Kong, SAR, China.
authors.forename: John P
authors.initials: JP
authors.lastname: Giesy
mesh_terms: D017738:Alkanesulfonic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001774:Blood Chemical Analysis; D002210:Caprylates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020007:Implants, Experimental; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D040521:Subcutaneous Tissue / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons; D010743:Phospholipids; C023036:perfluorooctanoic acid; D002784:Cholesterol; C076994:perfluorooctane sulfonic acid