Serotonin syndrome caused by olanzapine and clomipramine.
We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient's condition improved.
Verre
M
M
Anaesthesiology and Intensive Care Unit, S. Giovanni di Dio Hospital, Crotone, Italy. marioverre@tiscali.it
Bossio
F
F
Mammone
A
A
Piccirillo
M
M
Tancioni
F
F
Tortorella
V
V
Varano
M
M
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D002997:Clomipramine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D020230:Serotonin Syndrome / Q000139:chemically induced*
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine; D002997:Clomipramine