title: Clinical potential of an antitumor drug sensitivity test and diffusion-weighted MRI in a patient with a recurrent solid pseudopapillary tumor of the pancreas.
abstract: A solid pseudopapillary tumor (SPT) of the pancreas is a rare type of pancreatic neoplasm found predominantly in young women. SPTs typically behave as though benign; however, in some cases they also have malignant potential. We encountered a rare case of a recurrent SPT that developed 4 years after the initial surgery in an elderly male patient. Abdominal computed tomography (CT) revealed that the 61-year-old patient had four intra-abdominal masses, suggesting a recurrence of SPT. The patient had a history of distal pancreatectomy due to SPT in the pancreatic tail 4 years previously. These tumors showed positive signals on diffusion-weighted magnetic resonance imaging (MRI), and were treated successfully by aggressive surgical resection. Microscopic diagnosis was compatible with recurrent tumors of SPT. A chemosensitivity test, the collagen gel droplet-embedded culture drug sensitivity test (CD-DST), showed that the resected tumors were sensitive to several antitumor drugs. We suggest that the CD-DST may be used to indicate promising antitumor agents for treating SPTs with malignant tendencies. In addition, a diffusion-weighted MRI can be useful for accurately visualizing SPTs of the pancreas.
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Seta-tsukinowa, Otsu 520-2192, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Shimizu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murata
authors.forename: Eiji
authors.initials: E
authors.lastname: Mekata
authors.forename: Tohru
authors.initials: T
authors.lastname: Miyake
authors.forename: Hajime
authors.initials: H
authors.lastname: Abe
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kurumi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Endo
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Tohru
authors.initials: T
authors.lastname: Tani
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000601:surgery; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000601:surgery; D011859:Radiography; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine