title: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats.
abstract: BACKGROUND
  We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury.
  
  
  METHODS
  Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed.
  
  
  RESULTS
  Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1.
  
  
  CONCLUSIONS
  Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
authors.affiliation: Ministry of Health Ankara Training and Research Hospital, Second Urology Clinic, 11.Sokak 18/4 Bahçelievler, 06500 Ankara, Turkey. turgayakgul@gmail.com
authors.forename: Turgay
authors.initials: T
authors.lastname: Akgül
authors.forename: Ali
authors.initials: A
authors.lastname: Ayyildiz
authors.forename: Bariş
authors.initials: B
authors.lastname: Nuhoğlu
authors.forename: Ersagun
authors.initials: E
authors.lastname: Karagüzel
authors.forename: Elmas
authors.initials: E
authors.lastname: Oğüş
authors.forename: Hatice
authors.initials: H
authors.lastname: Yağmurdur
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ustün
authors.forename: Cankon
authors.initials: C
authors.lastname: Germiyanoğlu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D020441:Ginkgo biloba; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*; D013086:Spermatic Cord Torsion / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D013737:Testis / Q000098:blood supply / Q000187:drug effects; D000096983:Ginkgo Extract
chemical_list: D008315:Malondialdehyde; D009566:Nitrates; D009573:Nitrites; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract