High resolution regional elasticity mapping of the human prostate.
What is it that the clinician "feels" during a digital rectal examination? To answer this question, it is necessary to measure the elastic properties of the prostate and verify the stiffness values with histological examination. Therefore, we devised an Elasticity Mapping System to evaluate the elastic properties of various histopathological grades of prostate cancer in relation to benign prostatic hyperplasia (BPH) and normal tissue. The system consists of a micro tactile sensor, a three-axis (XYZ) with one (fine Z) micromanipulation stage, a stereoscope camera and a measurement chamber. Using this methodology we mapped the elasticity of human prostate cancer (CaP) and it was obviously observed that the node was significantly harder than surrounding normal tissues and had some textures.
Murayama
Yoshinobu
Y
College of Engineering, Nihon University, Koriyama, Fukushima, 9638642 Japan. murayama@ee.ce.nihon-u.ac.jp
Omata
Sadao
S
Yajima
Toshikuni
T
Peng
Qiyu
Q
Shishido
Keiichi
K
Peehl
Donna M
DM
Constantinou
Christos E
CE
D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D004548:Elasticity; D006801:Humans; D008297:Male; D010173:Palpation / Q000295:instrumentation* / Q000379:methods; D010812:Physical Stimulation / Q000295:instrumentation* / Q000379:methods; D011467:Prostate / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical