Specificity of relapses and metastases of experimental transplanted Ehrlich carcinoma and B16 melanoma.
Experiments on female (CBAxC57Bl/6)F1 mice with simultaneously transplanted Ehrlich carcinoma and B16 melanoma showed that removal of one of the primary nodes led to metastasizing of the removed tumor alone. It seems that this specificity of the inhibitory effect of the primary tumor can be explained by peculiarities of glycosylation and subsequent complex formation of serum proteins with the tumor.
Sitdikova
S M
SM
N. N. Blokhin National Oncological Research Center, Russian Academy of medical Sciences, Moscow.
Amandzholov
B S
BS
Kiselevskii
M V
MV
Donenko
F V
FV
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005260:Female; D008546:Melanoma, Experimental / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009364:Neoplasm Recurrence, Local; D009368:Neoplasm Transplantation