title: Silica-based mesoporous materials as drug delivery system for methotrexate release.
abstract: Antineoplastic methotrexate has been loaded through different soaking procedures on silica-based mesoporous materials and, successively, released mimicking an oral administration. The materials were prepared using a self-assembly mechanism in the presence of cationic surfactants with alkyl chain of 16, 12, and 10 carbon atoms in the synthesis mixture to obtain different pore diameter in the porous structure. Mesoporous materials were prepared as pure silica sample and in the presence of Al(OH)(3) in the synthesis mixture. Only alumina-silica samples were able to load methotrexate. The amounts of drug loaded and the in vitro release kinetics are a function of the pore size of the materials.
authors.affiliation: Dipartimento di Ingegneria Chimica e dei Materiali, Università della Calabria, Rende, Italia.
authors.forename: Ida Stefania
authors.initials: IS
authors.lastname: Carino
authors.forename: Luigi
authors.initials: L
authors.lastname: Pasqua
authors.forename: Flaviano
authors.initials: F
authors.lastname: Testa
authors.forename: Rosario
authors.initials: R
authors.lastname: Aiello
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.forename: Francesca
authors.initials: F
authors.lastname: Iemma
authors.forename: Nevio
authors.initials: N
authors.lastname: Picci
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D009584:Nitrogen / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D017655:Silicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D002593:Cetrimonium Compounds; D003692:Delayed-Action Preparations; C509968:MCM-41; D000644:Quaternary Ammonium Compounds; D017655:Silicon Compounds; D012972:Sodium Hydroxide; D000536:Aluminum Hydroxide; D012822:Silicon Dioxide; C022806:dodecyltrimethylammonium; D009584:Nitrogen; D008727:Methotrexate; D000077286:Cetrimonium