Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats.
BACKGROUND
We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury.


METHODS
Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed.


RESULTS
Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1.


CONCLUSIONS
Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
Akgül
Turgay
T
Ministry of Health Ankara Training and Research Hospital, Second Urology Clinic, 11.Sokak 18/4 Bahçelievler, 06500 Ankara, Turkey. turgayakgul@gmail.com
Ayyildiz
Ali
A
Nuhoğlu
Bariş
B
Karagüzel
Ersagun
E
Oğüş
Elmas
E
Yağmurdur
Hatice
H
Ustün
Hüseyin
H
Germiyanoğlu
Cankon
C
D000704:Analysis of Variance; D000818:Animals; D020441:Ginkgo biloba; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*; D013086:Spermatic Cord Torsion / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D013737:Testis / Q000098:blood supply / Q000187:drug effects; D000096983:Ginkgo Extract
D008315:Malondialdehyde; D009566:Nitrates; D009573:Nitrites; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract