title: Combining dual-source computed tomography coronary angiography and calcium scoring: added value for the assessment of coronary artery disease.
abstract: OBJECTIVE
  To prospectively investigate the diagnostic accuracy of dual-source 64-slice computed tomography coronary angiography (CTCA), calcium scoring (CS) and both methods combined for assessing significant coronary artery stenoses relative to conventional coronary angiography (CCA).
  
  
  METHODS
  Prospective, single-centre study conducted in a referral centre enrolling 74 consecutive patients (24 women; mean age 62 (SD 12) years) from August-October 2006. All study participants underwent CS, CTCA and CCA. Diagnostic accuracy was calculated for CS, CTCA and both methods combined relative to CCA. Not-evaluative segments at computed tomography were considered false positive.
  
  
  RESULTS
  CCA identified 139 stenoses in 36 patients. Average heart rate during CTCA was 68 (13) bpm (range 35-102 bpm), and 2% of segments (21/1001) in 11% of patients (8/74) were not evaluative. Considering these as false positives, per-patient sensitivity and specificity was 98% and 87%. When using CS cut-off values of 0 to exclude and >or=400 to predict stenosis, sensitivity and specificity of CS was 100% and 70%, respectively. Combining CS and CTCA in all patients correctly reclassified five patients, while six were falsely classified as stenotic, all of them correctly classified with CTCA alone. Using CS only in patients with not-evaluative segments correctly reclassified five patients while avoiding misclassifications (sensitivity 98%, specificity 100%).
  
  
  CONCLUSIONS
  Dual-source CTCA allows the diagnosis of significant stenoses with a high diagnostic accuracy. Selectively combining CS with CTCA in patients with not-evaluative coronary segments improves specificity from 87% to 100% without decreasing the high sensitivity of 98%.
authors.affiliation: Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Leschka
authors.forename: H
authors.initials: H
authors.lastname: Scheffel
authors.forename: L
authors.initials: L
authors.lastname: Desbiolles
authors.forename: A
authors.initials: A
authors.lastname: Plass
authors.forename: O
authors.initials: O
authors.lastname: Gaemperli
authors.forename: P
authors.initials: P
authors.lastname: Stolzmann
authors.forename: M
authors.initials: M
authors.lastname: Genoni
authors.forename: T
authors.initials: T
authors.lastname: Luescher
authors.forename: B
authors.initials: B
authors.lastname: Marincek
authors.forename: P
authors.initials: P
authors.lastname: Kaufmann
authors.forename: H
authors.initials: H
authors.lastname: Alkadhi
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*