title: Treatment strategies for the management of advanced colorectal liver metastases detected synchronously with the primary tumour.
abstract: The review summarises the contributions of chemotherapy, interventional radiology and surgery to the improved survival observed in patients with colorectal liver metastases. The rationale in favour of modern neoadjuvant chemotherapy regimens, of pro-generative manoeuvres to increase the volume of the future remnant liver, and of resection techniques that preserve its function is discussed. For advanced synchronous colorectal metastases, the arguments in favour of a reversed approach with systemic chemotherapy, liver surgery and colon surgery in that order, as opposed to the traditional approach of colon surgery first, or to a simultaneous liver and large bowel resection, are presented.
authors.affiliation: Department of Surgery, University Hospital of Geneva, Geneva, Switzerland. gilles.mentha@hcuge.ch
authors.forename: G
authors.initials: G
authors.lastname: Mentha
authors.forename: P
authors.initials: P
authors.lastname: Majno
authors.forename: S
authors.initials: S
authors.lastname: Terraz
authors.forename: L
authors.initials: L
authors.lastname: Rubbia-Brandt
authors.forename: P
authors.initials: P
authors.lastname: Gervaz
authors.forename: A
authors.initials: A
authors.lastname: Andres
authors.forename: A S
authors.initials: AS
authors.lastname: Allal
authors.forename: Ph
authors.initials: P
authors.lastname: Morel
authors.forename: A D
authors.initials: AD
authors.lastname: Roth
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017115:Catheter Ablation; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D011169:Portal Vein
chemical_list: D000970:Antineoplastic Agents