Vaccinia, Inc.--probing the functional substructure of poxviral replication factories.
Poxviruses replicate in viral factories in the host cell cytoplasm. In this issue of Cell Host & Microbe, Katsafanas and Moss identify discrete poxviral factory subdomains that contain locally synthesized virus proteins and specifically imported host proteins, and within which viral transcription and translation take place simultaneously. These factories thus comprise a highly structured virus organelle that isolates and coordinates late viral replication events, facilitating competition for cellular resources.
Condit
Richard C
RC
Department of Molecular Genetics and Microbiology, University of Florida, P.O. Box 100266, Gainesville, FL 31610, USA. condit@mgm.ufl.edu
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism / Q000821:virology; D006801:Humans; D011212:Poxviridae / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
D014764:Viral Proteins