Design of peptide nucleic acid by introduction of carbohydrate on lysine linker.
We synthesized "cartridge" type monomer involving mannose unit on lysine as a linker and additionally inserted it to peptide nucleic acid (PNA) oligomer. Advantage of this procedure is that functional molecule could be easily introduced into anywhere position of PNA without sacrificing basepairs, although such insertion lowered stability of the duplex with DNA.
Noguchi
Akira
A
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furocho, Chikusaku, Nagoya 4648603, Japan.
Asan
Hiroyuki
H
D008239:Lysine / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D020135:Peptide Nucleic Acids; D008239:Lysine; D008358:Mannose