SUMOylation-dependent function of a T-box transcriptional repressor in Caenorhabditis elegans.
T-box transcription factors are crucial developmental regulators, and they have not previously been associated with SUMOylation. In Caenorhabditis elegans, the Tbx2 subfamily member TBX-2 (T-box protein 2) is required for anterior pharyngeal muscle development. TBX-2 interacts with SUMOylation pathway enzymes, and loss of these enzymes phenocopies tbx-2 mutants. We hypothesize that TBX-2 functions as a SUMOylation-dependent transcriptional repressor. TBX-2 contains two consensus SUMOylation sites conserved in many T-box transcriptional repressors, and we suggest that the function of these T-box factors may similarly involve SUMOylation.
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Department of Biological Sciences and Laboratory for Molecular Biology, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, IL 60607, USA.
Okkema
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D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D016384:Consensus Sequence; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism / Q000502:physiology*; D020825:T-Box Domain Proteins / Q000502:physiology*
D025841:Small Ubiquitin-Related Modifier Proteins; C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins