title: Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice.
abstract: The antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia were investigated in the forced swimming test (FST) in ICR strain of male mice. Psoralidin significantly decreased immobility time and increased swimming behavior without altering climbing behavior in the mouse FST after oral administration for 1 h or 3 consecutive days. Psoralidin did not affect locomotor activity in the open-field test. After a 3-day treatment, psoralidin significantly increased 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in various brain regions, as well as, changed dopamine (DA) levels in striatum in mice exposed to FST. Psoralidin also ameliorated the elevations in serum corticotropin-releasing factor (CRF), adrenal corticotropin-releasing hormone (ACTH) and corticosterone concentrations induced by swimming stress in mice. These results suggested that psoralidin possessed potent antidepressant-like properties that were mediated via the monoamine neurotransmitter and the hypothalamic-pituitary-adrenal (HPA) axis systems.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Yi
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Li
authors.forename: Qun
authors.initials: Q
authors.lastname: Xu
authors.forename: Shi-Fu
authors.initials: SF
authors.lastname: Mo
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Fu-Xin
authors.initials: FX
authors.lastname: Jiang
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Lu
authors.forename: Ling-Dong
authors.initials: LD
authors.lastname: Kong
authors.forename: Hsiang-Fu
authors.initials: HF
authors.lastname: Kung
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D046353:Immobility Response, Tonic / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D029907:Psoralea / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012701:Serotonin / Q000032:analysis; D013550:Swimming / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D001572:Benzofurans; D003374:Coumarins; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; C102768:psoralidin; D003345:Corticosterone