Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines.
We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).
Jácomo
Rafael Henriques
RH
Melo
Raul Antonio Morais
RA
Souto
Fernanda Ribeiro
FR
de Mattos
Ederson Roberto
ER
de Oliveira
Claudia Teresa
CT
Fagundes
Evandro M
EM
Bittencourt
Henrique Neves da Silva
HN
Bittencourt
Rosane Isabel
RI
Bortolheiro
Teresa Cristina
TC
Paton
Eduardo J A
EJ
Bendlin
Rodrigo
R
Ismael
Sebastião
S
Chauffaille
Maria de Lourdes
Mde L
Silva
Dirceu
D
Pagnano
Katia Borgia B
KB
Ribeiro
Raul
R
Rego
Eduardo M
EM
D000293:Adolescent; D000328:Adult; D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
D018943:Anthracyclines; D014212:Tretinoin