title: Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
abstract: Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m(2)/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
authors.affiliation: Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Timonen
authors.forename: Simo
authors.initials: S
authors.lastname: Näyhä
authors.forename: Tapani
authors.initials: T
authors.lastname: Koskela
authors.forename: Eero
authors.initials: E
authors.lastname: Pukkala
mesh_terms: D000208:Acute Disease; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007251:Influenza, Human / Q000150:complications*; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology*; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology / Q000209:etiology; D012621:Seasons; D013472:Sunlight; D014808:Vitamin D Deficiency / Q000150:complications