Spindle microtubules: getting attached at both ends.
A recent study describes a novel role for the centrosomal protein Cep57 in attaching spindle microtubules to both kinetochores and centrosomes, suggesting similar mechanisms may be used for generating these two distinct linkages in mitosis.
DeLuca
Jennifer G
JG
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA. Jennifer.Deluca@ColoState.edu
D000818:Animals; D018385:Centrosome / Q000737:chemistry / Q000502:physiology; D006801:Humans; D018386:Kinetochores / Q000737:chemistry / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000502:physiology; D008870:Microtubules / Q000737:chemistry / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology; D008941:Spindle Apparatus / Q000737:chemistry / Q000502:physiology*
C474610:CEP57 protein, human; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins