Cutaneous reactions to chemotherapy: commonly seen, less described, little understood.
Chemotherapeutic and molecularly targeted agents are associated with a wide array of cutaneous toxicities. Despite the variety of toxicities, surprisingly little is understood regarding the pathogenesis underlying these reactions. This article reviews the most common cutaneous toxicities of cytotoxic chemotherapy and molecularly targeted systemic therapy, including extravasation of chemotherapy, with a discussion of the known and postulated underlying mechanisms of action. The need for developing a greater understanding of the basis of these reactions through more detailed study is evident.
Sanborn
Rachel E
RE
Division of Hematology and Medical Oncology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Mail Code L586, Portland, OR 97239-3098, USA. sanbornr@ohsu.edu
Sauer
David A
DA
D000970:Antineoplastic Agents / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D009369:Neoplasms / Q000188:drug therapy*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced*
D000970:Antineoplastic Agents; D007509:Irritants