title: Comparative analysis of staphylococcal adhesion and internalization by epithelial cells.
abstract: Multiple drug resistance to antibiotics is a major public health problem. Many mechanisms may be involved in such resistance. Increasing data have shown that Staphylococcus aureus can invade different types of nonphagocytic cells, which, in turn, may contribute to evasion of the toxicity of certain antibiotics. The fibronectin-binding proteins are required for S. aureus to adhere to and internalize into the host cells. We have shown that a two-component signal transduction system, SaeRS, is essential for bacterial adhesion and invasion of the epithelial cells.
authors.affiliation: Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN, USA.
authors.forename: Xudong
authors.initials: X
authors.lastname: Liang
authors.forename: Yinduo
authors.initials: Y
authors.lastname: Ji
mesh_terms: D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D001431:Bacteriological Techniques; D002460:Cell Line; D004847:Epithelial Cells / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D016106:Methicillin Resistance; D009154:Mutation; D015398:Signal Transduction; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D014157:Transcription Factors; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; C433805:SaeR protein, Staphylococcus aureus; D014157:Transcription Factors