title: Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
abstract: 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) is a nucleic acid analogue that has high affinity binding to its complementary RNA. Peroxisome proliferator-activated receptor (PPAR) y belongs to the nuclear hormone receptor superfamily and is a drug target in the treatment of type 2 diabetes. Here, we show the antisense effects of 2',4'-BNA oligonucleotides against PPARy in the human monocytic leukaemia cell line THP-1 and the human colorectal tumor cell line HCT116.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tachibana
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Katayama
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ueda
authors.forename: Mikako
authors.initials: M
authors.lastname: Sumitomo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tagami
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamasaki
authors.forename: Toshiya
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takao
authors.initials: T
authors.lastname: Hamakubo
authors.forename: Juro
authors.initials: J
authors.lastname: Sakai
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kodama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Doi
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000494:pharmacology*; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism
chemical_list: D001952:Bridged-Ring Compounds; D007004:Hypoglycemic Agents; D016376:Oligonucleotides, Antisense; D047495:PPAR gamma