Structural and functional changes in epitheliocytes of collecting tubes in renal papilla of Brattleboro rats treated with vasopressin.
The functional response of the kidney to desmopressin and morphological changes in epitheliocytes of collecting tubes were studied on homozygotic Brattleboro rats. Redistribution of beta-glucuronidase fractions and increase in the number of osmiophilic granules reflecting increased production of vasopressin-dependent proteins and hyaluronate hydrolase exocytosis were typical structural correlates of the effect of vasopressin.
Ivanova
L N
LN
Department of Physiology, Novosibirsk State University.
Lavrinenko
V A
VA
Shestopalova
L V
LV
Korotkova
S M
SM
D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism; D006651:Histocytochemistry; D006720:Homozygote; D007679:Kidney Medulla / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D007685:Kidney Tubules, Collecting / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D009994:Osmolar Concentration; D051381:Rats; D011910:Rats, Brattleboro; D017483:Receptors, Vasopressin / Q000819:agonists; D014563:Urodynamics; D019459:Urothelium / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D014667:Vasopressins / Q000235:genetics / Q000502:physiology*
D017483:Receptors, Vasopressin; D014667:Vasopressins; D005966:Glucuronidase; D003894:Deamino Arginine Vasopressin