title: Isomerization reactions of allylic alcohols into ketones with the Grubbs reagent.
abstract: Allylic alcohols were isomerized into ketones by the action of the Grubbs reagent. Some model alcohols were prepared and tested under similar conditions to reveal that less substituted alkenes rearrange more easily. More hindered alcohols are stable under these conditions, however, the simple allylic alcohols tend to isomerize producing ethyl ketone and the corresponding degraded methyl ketone.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nakashima
authors.forename: Sanae
authors.initials: S
authors.lastname: Okamoto
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sono
authors.forename: Motoo
authors.initials: M
authors.lastname: Tori
mesh_terms: D007202:Indicators and Reagents; D007536:Isomerism; D007659:Ketones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D007659:Ketones; D009942:Organometallic Compounds; D020005:Propanols; C524958:bis(trichlorohexylphosphine)benzylideneruthenium; C006463:allyl alcohol