[The potential clinical strategies for prevention and treatment of ischemic/hypoxic myocardial damage following severe burns].
Myocardial damage and decrease in blood-pumping function, which occur immediately after severe burns, not only lead to cardiac insufficiency, but also induce or exacerbate burn shock, constituting one of the initiating factors for visceral ischemic/hypoxic damage. Therefore, prompt and effective prevention and treatment of myocardial damage are important for resuscitation of burn patients with severe burns, especially in those whose hospitalization is delayed. In this review, the potential clinical strategies including angiotensin-converting enzyme inhibitors, modulation of beta-AR-mediated signal transduction and the "molecular switch Gsalpha/Gialpha", modulation of ion channels, the control of NO donor, the use of anti-inflammatory agents, and antioxidants, and energy metabolic modulation are introduced in details.
Huang
Yue-Sheng
YS
Institute of Burn Research , Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing 400038, PR China.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002056:Burns / Q000150:complications / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction
D000806:Angiotensin-Converting Enzyme Inhibitors