Biological response of chickens (Gallus gallus domesticus) induced by corticosterone and a bacterial endotoxin.
Experiments were conducted with chickens exposed to corticosterone and lipopolysaccharide (LPS) from Escherichia coli, with the aim of evaluating and differentiating their effects on endocrine, metabolic and immune response. Both, corticosterone and LPS significantly elevated plasma corticosterone concentrations and increased heterophil to lymphocyte (H/L) ratios 1 h, 3 h and 24 h post-treatments. Repeated exposure to corticosterone caused a prolonged elevation of plasma corticosterone concentration and H/L ratio. Data on blood metabolites demonstrated that corticosterone stimulated hyperglycaemia, hypercholesterolemia and hypertriglyceridemia. In contrast, LPS induced hypocholesterolemia and hypotriglyceridemia at 24 h post-injection. Weight gain and relative weight of the spleen and bursa were reduced in chickens treated with corticosterone. The LPS did not show any significant effect on weekly weight gain, but stimulated an increase in the relative weight of the spleen. Corticosterone initially stimulated antibody responsiveness to infectious bronchitis virus (IBV) vaccination, but thereafter the titres decreased. This was in contrast to LPS which depressed the antibody titre to IBV vaccination. It was concluded that the biological response of chickens induced by corticosterone could be differed from the response to LPS. The major difference occurred in metabolic, growth and immune activities. It appears that, both corticosterone and LPS differently alter physiological, metabolic and immunological responses of chickens through an activation of different molecular components (cytokines and chemokines) and neuroendocrine-immune network systems.
Shini
Shaniko
S
School of Animal Studies, University of Queensland, Gatton QLD 4343, Australia. s.shini@uq.edu.au
Kaiser
Pete
P
Shini
Agim
A
Bryden
Wayne L
WL
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002060:Bursa of Fabricius / Q000033:anatomy & histology / Q000187:drug effects; D002645:Chickens / Q000097:blood / Q000276:immunology / Q000378:metabolism; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D004703:Endocrine System / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D007107:Immune System / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D053858:Metabolic Networks and Pathways / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D011201:Poultry Diseases / Q000517:prevention & control; D013312:Stress, Physiological / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism; D014611:Vaccination
D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D003345:Corticosterone