Flow cytometry in the diagnosis of drug-induced thrombocytopenia: two illustrative cases.
Drug-induced thrombocytopenia is a challenging diagnosis in the clinical practice because of the many drugs or alternative causes that may be implicated. Exact identification of such drug(s) is required to guide future management and avoid re-exposure. We describe two cases of isolated thrombocytopenia in which cytometric analysis, a readily available technique, allowed the identification of the causative drug in the context of complex therapies (rifampicin and abciximab causing late onset thrombocytopenia).
Scognamiglio
Francesca
F
Department of Hematology, San Bortolo Hospital, Vicenza, Italy.
Corso
Chiara
C
Madeo
Domenico
D
Castaman
Giancarlo
G
Visco
Carlo
C
Borghero
Carlo
C
Ruggeri
Marco
M
Rodeghiero
Francesco
F
D000077284:Abciximab; D015906:Angioplasty, Balloon, Coronary; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D000925:Anticoagulants / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy; D010019:Osteomyelitis / Q000188:drug therapy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D012293:Rifampin / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D001323:Autoantibodies; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D002939:Ciprofloxacin; D012293:Rifampin; D000077284:Abciximab