A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects.
Autologous chondrocyte implantation (ACI) is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Challenges to successful ACI outcomes include limitation in defect size and geometry as well as inefficient cell retention. Second-generation ACI procedures have thus focused on developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. In the future, third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair.
Tuan
Rocky S
RS
Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. tuanr@mail.nih.gov
D000818:Animals; D002357:Cartilage Diseases / Q000473:pathology / Q000601:surgery; D002358:Cartilage, Articular / Q000473:pathology*; D019902:Chondrocytes / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D016378:Tissue Transplantation / Q000379:methods / Q000639:trends; D014182:Transplantation, Autologous