title: Comparative study on the insertion behavior of cerebral microprobes.
abstract: A series of experiments has been conducted with probes made from silicon, glass, tungsten and polyimide within a developed brain phantom, and the insertion behavior, forces and dimpling are compared to in vitro and in vivo models. This allows the choice of proper insertion parameters and probe structure to reach a compromise between needle stability and tissue trauma as a result of insertion. According to the performed experiments, the reduced interfacial area between the needle tip and the brain will result in reduced insertion force. High insertion speed (100 mm/min) reduces the dimpling but not the penetration force necessarily. In vivo insertion and retraction of the fragile probes made from silicon is possible without pia and/or dura removal.
authors.affiliation: Department of Microsystems Engineering (IMTEK), Microsystems Materials Laboratory (MML), University of Freiburg, Georges-Koehler-Allee 103, D-79110 Freiburg, Germany.
authors.forename: Neda Haj
authors.initials: NH
authors.lastname: Hosseini
authors.forename: Rudiger
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kisban
authors.forename: Thomas
authors.initials: T
authors.lastname: Stieglitz
authors.forename: Oliver
authors.initials: O
authors.lastname: Paul
authors.forename: Patrick
authors.initials: P
authors.lastname: Ruther
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D004867:Equipment Design; D005898:Glass; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008839:Microelectrodes; D019047:Phantoms, Imaging; D012117:Resins, Synthetic; D012825:Silicon; D014414:Tungsten
chemical_list: D012117:Resins, Synthetic; C029945:polyimide resin; D014414:Tungsten; D012825:Silicon