title: Targeting the Plasmodium vivax Duffy-binding protein.
abstract: Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.
authors.affiliation: Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. cchitnis@icgeb.res.in <cchitnis@icgeb.res.in>
authors.forename: Chetan E
authors.initials: CE
authors.lastname: Chitnis
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000378:metabolism; D000953:Antigens, Protozoan / Q000276:immunology / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D004375:Duffy Blood-Group System / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D006801:Humans; D016780:Malaria, Vivax / Q000378:metabolism / Q000517:prevention & control*; D016790:Plasmodium knowlesi / Q000378:metabolism; D010966:Plasmodium vivax / Q000502:physiology*; D015800:Protozoan Proteins / Q000276:immunology / Q000378:metabolism*; D016052:Protozoan Vaccines; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*
chemical_list: C473745:ACKR1 protein, human; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D018925:Chemokines; D004375:Duffy Blood-Group System; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011956:Receptors, Cell Surface