Functional reactivity of oxanine: its biological meanings and biotechnological applications.
Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.
Pack
Seung Pil
SP
Institue of Advanced Energy, Kyoto University, Gokaso, Uji 611-0011, Japan.
Doi
Akihiro
A
Kamisetty
Nagendra Kumar
NK
Nonogawa
Mitsuru
M
Kodaki
Tsutomu
T
Makino
Keisuke
K
D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D001709:Biotechnology; D015342:DNA Probes / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D011684:Purine Nucleosides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000588:Amines; D000596:Amino Acids; D015342:DNA Probes; D009838:Oligodeoxyribonucleotides; D011506:Proteins; D011684:Purine Nucleosides; D013438:Sulfhydryl Compounds; C468766:oxanine; C007940:hexylamine