Epidermodysplasia verruciformis associated with isolated IgM deficiency.
A 20 year-old man presented to our clinic with multiple warts on both hands and tumoral lesions on his face but otherwise healthy. On dermatological examination, numerous brown-black papular lesions, changing from 2 to 5 cm in diameter were found on his face along with multiple, flesh-coloured, flat-topped papules on the dorsa of his hands. A tumoral lesion, approximately 3 cm in diameter on the right side of his forehead and desquamated erythematous macules were also observed on the trunk. Laboratory investigations showed that serum immunoglobulin M (IgM) level was decreased. The histopathological examination of verrucous lesions on the hands was consistent with epidermodysplasia verruciformis and the histopathological diagnosis of the tumoral lesion was squamous cell carcinoma.
Gul
Ulker
U
Department of Dermatology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Soylu
Secil
S
Yavuzer
Rana
R
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004819:Epidermodysplasia Verruciformis / Q000473:pathology*; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology
D007075:Immunoglobulin M