title: Plasma lipid peroxidation and antioxidant status of Parkinson's disease patients in the Indian population.
abstract: Present study was to assess lipid peroxidation and antioxidant enzymes in the blood of the Parkinson's disease (PD) patients in the Indian population. It may be useful to develop peripheral markers, for the diagnosis and prognosis of Parkinson's disease during lifetime. Malondialdehyde content was increased in patients with PD (2 fold), with respect to the activity of superoxide-dismutase (p<0.001). The levels of glutathione (p<0.001) and blood thiols were decreased. No changes were observed in gamma-GTP, glutathione peroxidase and glutathione reductase. Increased lipid peroxidation, decreased glutathione levels and increased superoxide dismutase activity in the blood of PD patients indicate oxidative stress.
authors.affiliation: Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Aabha
authors.initials: A
authors.lastname: Sharma
authors.forename: Pushpinder
authors.initials: P
authors.lastname: Kaur
authors.forename: Binu
authors.initials: B
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Prabhakar
authors.forename: K D
authors.initials: KD
authors.lastname: Gill
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007194:India; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione