title: Effectiveness of mesalamine and propolis in experimental colitis.
abstract: This study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.
authors.affiliation: Department of General Surgery, Mustafa Kemal University, Antakya-Hatay, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aslan
authors.forename: Muhyittin
authors.initials: M
authors.lastname: Temiz
authors.forename: Esin
authors.initials: E
authors.lastname: Atik
authors.forename: Gurbuz
authors.initials: G
authors.lastname: Polat
authors.forename: Nuray
authors.initials: N
authors.lastname: Sahinler
authors.forename: Elmir
authors.initials: E
authors.lastname: Besirov
authors.forename: Nedim
authors.initials: N
authors.lastname: Aban
authors.forename: Cem Kaan
authors.initials: CK
authors.lastname: Parsak
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003092:Colitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004359:Drug Therapy, Combination; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019804:Mesalamine / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D011429:Propolis / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D009569:Nitric Oxide; D019804:Mesalamine; D008315:Malondialdehyde; D011429:Propolis; D009195:Peroxidase