Easy and Safe preparations of (diacetoxyiodo) arenes from iodoarenes, with urea-hydrogen peroxide adduct (UHP) as the oxidant and the fully interpreted (1)H- and (13)C-NMR spectra of the products.
An easy and safe, though only moderately effective method is presented for preparing (diacetoxyiodo)arenes, ArI(OAc)2, from iodoarenes, ArI, using the commercially available and easily handled urea-hydrogen peroxide adduct (UHP) as the oxidant. The reactions take place in anhydrous AcOH/Ac2O/AcONa (a catalyst)mixtures, at 40 oC for 3.5 h to afford the purified ArI(OAc)2 in 37-78% yields. The fully interpreted (1)H- and (13)C-NMR spectra of the ArI(OAc)2 products are reported.
Zielinska
Agnieszka
A
Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, 1 Banacha Street, PL 02-097 Warsaw, Poland.
Skulski
Lech
L
D000077463:Carbamide Peroxide; D002247:Carbon Isotopes / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D004338:Drug Combinations; D006859:Hydrogen / Q000737:chemistry*; D017613:Iodine Compounds / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000138:chemical synthesis*; D016877:Oxidants / Q000494:pharmacology; D010545:Peroxides / Q000494:pharmacology*; D044366:Transition Temperature; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D002247:Carbon Isotopes; D004338:Drug Combinations; D017613:Iodine Compounds; D009281:Naphthalenes; D016877:Oxidants; D010545:Peroxides; D000077463:Carbamide Peroxide; D006859:Hydrogen; D014508:Urea