title: Transmission of anaplastic large cell lymphoma via organ donation after cardiac death.
abstract: Recently, donation after cardiac death (DCD) has been encouraged in order to expand the donor pool. We present a case of anaplastic T-cell lymphoma transmitted to four recipients of solid organ transplants from a DCD donor suspected of having bacterial meningitis. On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma. The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden. We recommend transplanting organs from donors with suspected bacterial meningitis only after identification of the infectious organism. In cases of lymphoma transmission, excision of the graft may be the only chance at long-term survival.
authors.affiliation: Department of Surgery, New York University Medical Center, New York, NY, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Harbell
authors.forename: T B
authors.initials: TB
authors.lastname: Dunn
authors.forename: M
authors.initials: M
authors.lastname: Fauda
authors.forename: D G
authors.initials: DG
authors.lastname: John
authors.forename: A S
authors.initials: AS
authors.lastname: Goldenberg
authors.forename: L W
authors.initials: LW
authors.lastname: Teperman
mesh_terms: D000293:Adolescent; D000328:Adult; D003643:Death; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000209:etiology* / Q000382:microbiology; D008297:Male; D016920:Meningitis, Bacterial / Q000635:transmission; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D016035:Pancreas Transplantation / Q000009:adverse effects; D014019:Tissue Donors