N,N'-SUBStituted 1,2,5 thiadiazolidine 1,1-dioxides: synthesis, selected chemical and spectral proprieties and antimicrobial evaluation.
The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.
Bendjeddou
Amel
A
Laboratoire de Chimie Organique Appliquée, Groupe de Chimie Bioorganique, Faculté des Sciences, Département de Chimie, Université d' Annaba. Algeria.
Djeribi
Ryad
R
Regainia
Zine
Z
Aouf
Nour-Eddine
NE
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000737:chemistry*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D013830:Thiadiazoles