title: Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.
abstract: Transection of the direct cortico-motoneuronal pathway at the mid-cervical segment of the spinal cord in the macaque monkey results in a transient impairment of finger movements. Finger dexterity recovers within a few months. Combined brain imaging and reversible pharmacological inactivation of motor cortical regions suggest that the recovery involves the bilateral primary motor cortex during the early recovery stage and more extensive regions of the contralesional primary motor cortex and bilateral premotor cortex during the late recovery stage. These changes in the activation pattern of frontal motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury.
authors.affiliation: Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Onoe
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Morichika
authors.forename: Sergei
authors.initials: S
authors.lastname: Perfiliev
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsukada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isa
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001931:Brain Mapping; D005260:Female; D005385:Fingers / Q000503:physiopathology*; D018755:GABA Agonists; D007858:Learning; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D009048:Motor Skills; D009118:Muscimol; D009415:Nerve Net / Q000503:physiopathology; D049268:Positron-Emission Tomography; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation; D013997:Time Factors
chemical_list: D018755:GABA Agonists; D009118:Muscimol