Cytochrome c biogenesis in mitochondria.
As part of the respiratory chain, c-type cytochromes are essential electron transporters. They are characterized by the covalent attachment of a heme prosthetic group. The biogenesis of these proteins includes all the processes leading to this fixation. Yeast and animals have evolved a comparatively simple mechanism relying on cytochrome c heme lyases. In contrast, plant mitochondria have kept a maturation pathway inherited from their prokaryote ancestor. It involves Ccm proteins encoded in both the nuclear and the mitochondrial genomes of plants. These proteins compose a heme delivery pathway, include an ABC transporter, a redox protein and a putative heme lyase.
Giegé
P
P
Institut de Biologie Moléculaire des Plantes du CNRS, Université Louis Pasteur, 12 rue du général Zimmer, 67084 Strasbourg, France.
Grienenberger
J M
JM
Bonnard
G
G
D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000502:physiology; D001419:Bacteria / Q000201:enzymology; D045304:Cytochromes c / Q000096:biosynthesis / Q000235:genetics*; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D016681:Genome, Fungal; D018745:Genome, Plant; D006418:Heme / Q000378:metabolism; D008190:Lyases / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000201:enzymology*; D010944:Plants / Q000201:enzymology / Q000235:genetics*
D018528:ATP-Binding Cassette Transporters; D006418:Heme; D045304:Cytochromes c; D008190:Lyases; C031581:cytochrome C synthetase