title: Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation.
abstract: This retrospective cohort study aimed at determining whether overweight children undergoing allogeneic stem cell transplantation (SCT) had inferior overall survival compared with children who were not overweight. Children >/=2 years of age who received allogeneic SCT were included. Overweight was defined as a body mass index >/= 95th percentile; 54/325 (17%) children were overweight. Overall survival at 5 years was significantly inferior at 46.6 +/- 7.3% in the overweight group compared with 59.5 +/- 3.2% in the non-overweight group (P = 0.02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight.
authors.affiliation: Division of Haematology/Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Sean
authors.initials: S
authors.lastname: Bulley
authors.forename: Adam
authors.initials: A
authors.lastname: Gassas
authors.forename: L Lee
authors.initials: LL
authors.lastname: Dupuis
authors.forename: Richard
authors.initials: R
authors.lastname: Aplenc
authors.forename: Joseph
authors.initials: J
authors.lastname: Beyene
authors.forename: Mark L
authors.initials: ML
authors.lastname: Greenberg
authors.forename: John J
authors.initials: JJ
authors.lastname: Doyle
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
mesh_terms: D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008297:Male; D050177:Overweight / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome