title: An expedient, facile and simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles from the Baylis-Hillman bromides in aqueous media.
abstract: This protocol is for an expedient and operationally simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles in high yields from the corresponding Baylis-Hillman bromides. The reaction proceeds via the successive treatment with 1,4-diazabicyclo(2.2.2)octane (DABCO) for 15 min and sodium borohydride for 15 min in aqueous media [tetrahydrofuran (THF):H2O (1:1)] at room temperature.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. dbsc@uohyd.ernet.in
authors.forename: Deevi
authors.initials: D
authors.lastname: Basavaiah
authors.forename: Kanumuri Ramesh
authors.initials: KR
authors.lastname: Reddy
authors.forename: Nagaswamy
authors.initials: N
authors.lastname: Kumaragurubaran
mesh_terms: D001965:Bromides / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C526598:2-methylene-3-phenylpropanenitrile; D001965:Bromides; D009570:Nitriles; D010666:Phenylpropionates; C526597:methyl 2-methylene-3-phenylpropanoate