title: Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis.
abstract: Various clinical prognostic scoring systems (PSSs) have been suggested as means of selecting high-risk chronic idiopathic myelofibrosis (CIMF) patients at diagnosis. The WHO has recently proposed strict diagnostic criteria for CIMF, and the European consensus for bone marrow fibrosis (BMF) grading recommends 4 classes. It has been suggested that BMF grading may play a prognostic role in CIMF, but it has never been compared with the other PSSs in the same patients. We tested a prognostic model for overall survival (OS) based on the WHO criteria and BMF grading in 113 consecutive patients with chronic myeloproliferative disorders (98 with CIMF and 15 with postpolycythemic myelofibrosis), and compared the findings with those of PSSs. The results showed that our model is significantly associated with different OSs and, unlike the other PSSs, clearly discriminates the OS of intermediate- and high-risk patients.
authors.affiliation: Ematologia I, Centro Trapianti di Midollo, University of Milan, Milano, Italy. claudiavener@tiscali.it
authors.forename: Claudia
authors.initials: C
authors.lastname: Vener
authors.forename: Nicola Stefano
authors.initials: NS
authors.lastname: Fracchiolla
authors.forename: Umberto
authors.initials: U
authors.lastname: Gianelli
authors.forename: Rossella
authors.initials: R
authors.lastname: Calori
authors.forename: Franca
authors.initials: F
authors.lastname: Radaelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Iurlo
authors.forename: Sabrina
authors.initials: S
authors.lastname: Caberlon
authors.forename: Giancarla
authors.initials: G
authors.lastname: Gerli
authors.forename: Leonardo
authors.initials: L
authors.lastname: Boiocchi
authors.forename: Giorgio Lambertenghi
authors.initials: GL
authors.lastname: Deliliers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002908:Chronic Disease; D005060:Europe; D006454:Hemoglobins / Q000378:metabolism; D008679:Metaplasia / Q000473:pathology; D011086:Polycythemia / Q000145:classification / Q000473:pathology; D055728:Primary Myelofibrosis / Q000097:blood / Q000145:classification / Q000473:pathology; D011379:Prognosis; D003245:Consensus Statements as Topic
chemical_list: D006454:Hemoglobins