title: Solution-phase synthesis of a combinatorial library of 3-[4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides.
abstract: The parallel solution-phase synthesis of a new combinatorial library of 3-[4-(R1-coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides 9 has been developed. The synthesis involves two steps: 1) the synthesis of core building blocks - 3- [4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acids, 6 - by the reaction of 3-(omega-bromacetyl)coumarins 1 with 3-amino(thioxo)methylcarbamoylpropanoic acid (5); 2) the synthesis of the corresponding 3-[4-(coumarin-3-yl)-1,3-thiazol-2-yl- carbamoyl]propanoic acids amides 9 using 1,1'-carbonyldimidazole as a coupling reagent. The advantages of the method compared to existing ones are discussed.
authors.affiliation: National Pharmaceutical University, Kharkiv, Ukraine. kosn@ic.kharkov.ua.
authors.forename: Irina O
authors.initials: IO
authors.lastname: Zhuravel
authors.forename: Sergiy M
authors.initials: SM
authors.lastname: Kovalenko
authors.forename: Sergiy V
authors.initials: SV
authors.lastname: Vlasov
authors.forename: Valentin P
authors.initials: VP
authors.lastname: Chernykh
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D008954:Models, Biological; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D012996:Solutions / Q000737:chemistry*
chemical_list: D000577:Amides; D003374:Coumarins; D011422:Propionates; D054852:Small Molecule Libraries; D012996:Solutions