title: [Ciprofloxacin and therapy of urinary tract infections, including those due to Staphylococcus saprophyticus].
abstract: Staphylococcus saprophyticus is one of the main pathogens of cystitis in young women. The human biotopes are contaminated by the staphylococcus on direct contacts with domestic animals or after using not properly cooked food of animal origin. Young women are more susceptible to colonization of the urinary tract by S. saprophyticus vs. the other contingents. Sexual intercourse is conducive to the colonization and infection. Shifts in the urinary tract microflora due to the use of spermicide, as well as candidiasis promote colonization of the urinary tract by S. saprophyticus. At present fluoroquinolones are considered as a significant independent group of chemotherapeutics within the class of quinolones, inhibitors of DNA gyrase, characterized by high clinical efficacy in the treatment of urinary tract infections. Especially significant clinical experience with ciprofloxacin in the therapy of urinary tract infections is available.
authors.forename: D V
authors.initials: DV
authors.lastname: Ivanov
authors.forename: S V
authors.initials: SV
authors.lastname: Budanov
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000829:Animals, Domestic; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002177:Candidiasis; D002648:Child; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology / Q000627:therapeutic use; D005516:Food Microbiology; D006801:Humans; D008297:Male; D008461:Meat Products; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D013089:Spermatocidal Agents / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D059005:Topoisomerase II Inhibitors; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D019384:Nucleic Acid Synthesis Inhibitors; D013089:Spermatocidal Agents; D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin