Synthesis of an artificial oligonucleotide an efficient cycloaddition reaction.
We developed a new class of artificial oligonucleotides bearing triazole linkers between furanose-like cyclic structures with nucleobase. Elongation reaction of the oligonucleotide was achieved efficiently by [3 + 2] cycloaddition reaction between acetylene and azide.
Fujino
Tomoko
T
Department of Chemistry, Tohoku University, Aoba-ku, Sendai, 980-8578, Japan.
Marine
Guillot
G
Nakamura
Eiichi
E
D000114:Acetylene / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
D001386:Azides; D009841:Oligonucleotides; D014230:Triazoles; D000114:Acetylene