title: Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var. corrugata.
abstract: Nine novel steroidal glycosides substituted with the orthoacetate groups, compounds 1-5 based on the aglycon of 12-O-acetyl-20-O-benzoyl-dihydrosarcostin 8,14,18-orthoacetate and compounds 6-9 based on the aglycon of 12-O-acetyl-20-O-benzoyl-dihydrosarcostin 14,17,18-orthoacetate, were isolated from Dregea sinensis var. corrugata. Their structures were deduced on the basis of chemical and spectral evidences. Compound 1 showed moderate anti-inflammatory activity.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.
authors.forename: Yunbao
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Shishan
authors.initials: S
authors.lastname: Yu
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Youcai
authors.initials: Y
authors.lastname: Hu
authors.forename: Shuanggang
authors.initials: S
authors.lastname: Ma
mesh_terms: D000085:Acetates / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D006027:Glycosides; D013256:Steroids