Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) is a nucleic acid analogue that has high affinity binding to its complementary RNA. Peroxisome proliferator-activated receptor (PPAR) y belongs to the nuclear hormone receptor superfamily and is a drug target in the treatment of type 2 diabetes. Here, we show the antisense effects of 2',4'-BNA oligonucleotides against PPARy in the human monocytic leukaemia cell line THP-1 and the human colorectal tumor cell line HCT116.
Tachibana
Keisuke
K
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Katayama
Tatsuya
T
Ueda
Chihiro
C
Sumitomo
Mikako
M
Tagami
Masayuki
M
Ishimoto
Kenji
K
Yamasaki
Daisuke
D
Tanaka
Toshiya
T
Hamakubo
Takao
T
Sakai
Juro
J
Kodama
Tatsuhiko
T
Obika
Satoshi
S
Imanishi
Takeshi
T
Doi
Takefumi
T
D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000494:pharmacology*; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism
D001952:Bridged-Ring Compounds; D007004:Hypoglycemic Agents; D016376:Oligonucleotides, Antisense; D047495:PPAR gamma