Primary ovarian rhabdomyosarcoma in children.
Although rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, primary rhabdomyosarcomas of the ovary are extremely rare, with only eight well-documented pediatric cases previously reported in the literature. We present two additional cases: an alveolar RMS originating in the right ovary with metastatic spread to the splenic flexure of the colon and to both lungs in a 13-year-old African American girl, and an embryonal RMS arising in the right ovary of a 6-year-old Caucasian girl with pre-operative intra-abdominal rupture and a malignant right pleural effusion. Both patients had complete resection of their primary tumors and received chemotherapy including vincristine, doxorubicin and cyclophosphamide with good response to therapy. Both are alive 8 and 9 months post-operatively.
Cribbs
Randolph K
RK
Division of Pediatric Surgery, Emory University, Atlanta, GA 30322, USA. Randolph_cribbs@oz.ped.emory.edu
Shehata
Bahig M
BM
Ricketts
Richard R
RR
D000293:Adolescent; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000628:therapy; D010052:Ovariectomy / Q000379:methods; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed