title: Influence of bleaching on the enantiomeric disposition of amphetamine-type stimulants in hair.
abstract: The aim of this work was to study the influence of hair bleaching on the enantiomeric ratios of amphetamine-type stimulants (ATS), including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyethylamphetamine. Hair specimens from 14 STA users were treated with a commercial bleaching product during 40 min. After alkaline digestion and solid-phase extraction of bleached and non-bleached hair, the STA enantiomers were derivatised with an in-house synthesised chiral reagent, the (2S,4R)-N-heptafluorobutyryl-4-heptafluorobutoyloxy-prolyl chloride. The diastereoisomers were quantified by GC/MS-NCI. The results showed that the concentrations of all enantiomers decreased in bleached hair in comparison with the non-treated hair (median values between 20 and 39%). The enantiomeric ratios of the STA in bleached hair were not significantly different from those determined in non-treated hair. Our findings pointed out that bleaching treatments decrease concentrations of STA in hair without influencing their enantiomeric ratios.
authors.affiliation: National Laboratory of Health, Toxicology Division, University of Luxembourg, 162A avenue de la Faïencerie, L-1511, Luxembourg. liliane.martins@lns.etat.lu
authors.forename: Liliane Ferreira
authors.initials: LF
authors.lastname: Martins
authors.forename: Michel
authors.initials: M
authors.lastname: Yegles
authors.forename: Detlef
authors.initials: D
authors.lastname: Thieme
authors.forename: Robert
authors.initials: R
authors.lastname: Wennig
mesh_terms: D000662:Amphetamines / Q000032:analysis* / Q000737:chemistry; D004202:Disinfectants / Q000008:administration & dosage*; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006801:Humans; D012973:Sodium Hypochlorite / Q000008:administration & dosage*; D013237:Stereoisomerism
chemical_list: D000662:Amphetamines; D004202:Disinfectants; D012973:Sodium Hypochlorite