title: Histological osseointegration of a calciumphosphate bone substitute material in patients.
abstract: The aim of this study was to evaluate histological and radiological osseointegration characteristics of implanted di-/tri-calciumphosphate in patients bone substitute material in opening-wedge osteotomies patients. Up to now the hypothesis of bioresorption and replacement with vital bone bases on numerous animal studies showing complete remodelling within 12-26 weeks. Histological patient studies hardly exist. In this study 13 patient biopsies were collected 16 months after tibial osteotomy. Unlike animal studies the results showed mainly incorporated avital cement residues (38%) as well as new bone formation (61%). Radiological scoring confirmed increasing signs of osseointegration and an incomplete resorption. In conclusion degradation and replacement of di-/tri-calciumphosphate seems to be less accelerated in patients than prior animal studies indicated. Nevertheless, it shows excellent biocompatibility, good osteoconductive characteristics and may represents a useful alternative to autogenous graft.
authors.affiliation: Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Meyer
authors.forename: Thilo
authors.initials: T
authors.lastname: Floerkemeier
authors.forename: Henning
authors.initials: H
authors.lastname: Windhagen
mesh_terms: D020341:Absorbable Implants; D001706:Biopsy; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D001857:Bone Matrix / Q000254:growth & development / Q000601:surgery; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates; D006801:Humans; D020007:Implants, Experimental; D016348:Osseointegration; D010012:Osteogenesis; D010027:Osteotomy / Q000534:rehabilitation; D013977:Tibia / Q000254:growth & development / Q000473:pathology / Q000601:surgery; D013997:Time Factors
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates