title: An increase in HbA1c after percutaneous coronary intervention raises the risk for restenosis in patients without Type 2 diabetes mellitus.
abstract: OBJECTIVE
  The influence of dynamic changes in glycated haemoglobin (HbA(1c)) on restenosis after elective percutaneous coronary intervention (PCI) in patients without diabetes has not been analysed. Therefore, the rate of restenosis was investigated after elective PCI in 101 consecutive patients without diabetes mellitus in relation to dynamic changes of HbA(1c) levels.
  
  
  METHODS
  Follow-up angiography was performed in all patients 4-6 months after intervention.
  
  
  RESULTS
  Multivariate analysis demonstrated that the change in HbA(1c) between first and second coronary angiography was the most powerful metabolic parameter for prediction of restenosis. The odds ratio for restenosis was 3.0 (95% CI 1.0-9.0) for any increase in HbA(1c) and 1.9 (95% CI 1.1-3.5) for an HbA(1c) increase of 0.2%.
  
  
  CONCLUSIONS
  Hence, chronic changes in the glucometabolic environment influence the incidence of restenosis after PCI in patients without diabetes.
authors.affiliation: Clinic III for Internal Medicine, University of Köln, Cologne, Germany. Holger.Diedrichs@uni-koeln.de
authors.forename: H
authors.initials: H
authors.lastname: Diedrichs
authors.forename: R
authors.initials: R
authors.lastname: Pfister
authors.forename: J
authors.initials: J
authors.lastname: Hagemeister
authors.forename: J
authors.initials: J
authors.lastname: Müller-Ehmsen
authors.forename: K F
authors.initials: KF
authors.lastname: Frank
authors.forename: H-W
authors.initials: HW
authors.lastname: Höpp
authors.forename: E
authors.initials: E
authors.lastname: Erdmann
authors.forename: C A
authors.initials: CA
authors.lastname: Schneider
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001786:Blood Glucose / Q000378:metabolism; D023903:Coronary Restenosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin