Novel varicella-zoster virus glycoprotein E gene mutations associated with genotypes A and D.
Here, we describe the association of certain varicella-zoster virus (VZV) genotypes with unique glycoprotein E (gE) gene mutations. Within 45 analyzed VZV wild-type strains of genotypes A and D, five novel gE mutations were discovered. A statistically significant (P < 0.0001) association of certain gE mutations with VZV genotype D was found.
Schmidt-Chanasit
Jonas
J
Institute of Medical Virology, Hospital of the Johann Wolfgang Goethe University, D-60596 Frankfurt am Main, Germany. jonassi@gmx.de
Bleymehl
Karoline
K
Schäd
Susanne G
SG
Gross
Gerd
G
Ulrich
Rainer G
RG
Doerr
Hans Wilhelm
HW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002644:Chickenpox / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006562:Herpes Zoster / Q000821:virology; D014645:Herpesvirus 3, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D014759:Viral Envelope Proteins / Q000235:genetics*
D004279:DNA, Viral; D014759:Viral Envelope Proteins; C056913:glycoprotein E, varicella-zoster virus