title: Gram-negative bacillary community acquired meningitis is not a rare entity in last two decades.
abstract: The aim of this short note is to assess gram-negative bacillary community acquired meningitis (CBM) and nosocomial meningitis (NM) within 17 years nationwide survey. All cases of gram-negative bacillary CBM within 1990-2007 were assessed in national database of 372 patients with bacterial meningitis: 69 of gram-negative cases were nosocomial and 24 of gram-negative meningitis cases were CBM. Those 24 cases were compared with all CBM (201 cases) for risk factors and outcome. Among nosocomial gram-negative pathogens, A. baumannii in 23 cases, Ps. aeruginosa in 15 cases and Enterobacteriaceae in 31 cases were isolated. Among CBM, in 13 cases Enterobacteriaceae (Escherichia coli 6, Klebsiella pneumoniae 3, Proteus mirabilis 2, Enterobacter cloacae 2), in 5 cases Ps. aeruginosa and in 6 cases Acinetobacter baumannii were isolated from cerebrospinal fluid (CSF). The only significant risk factor for CBM due to gram-negative bacilli was neonatal age (12.5% vs. 3.5%, p=0.04) as underlying disease. However, mortality among gram-negative bacillary meningitis was significantly higher (12.4% vs. 37.5%, p=0.001) in comparison to other meningitis.
authors.affiliation: University of Trnava, School of Health and Social Work, Trnava, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Taziarova
authors.forename: K
authors.initials: K
authors.lastname: Holeckova
authors.forename: A
authors.initials: A
authors.lastname: Lesnakova
authors.forename: V
authors.initials: V
authors.lastname: Sladeckova
authors.forename: M
authors.initials: M
authors.lastname: Bartkovjak
authors.forename: S
authors.initials: S
authors.lastname: Seckova
authors.forename: P
authors.initials: P
authors.lastname: Bukovinova
authors.forename: F
authors.initials: F
authors.lastname: Hvizdak
authors.forename: V
authors.initials: V
authors.lastname: Svabova
authors.forename: L
authors.initials: L
authors.lastname: Findova
authors.forename: P
authors.initials: P
authors.lastname: Kisac
authors.forename: P
authors.initials: P
authors.lastname: Beno
authors.forename: F
authors.initials: F
authors.lastname: Bauer
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: M
authors.initials: M
authors.lastname: Karvaj
authors.forename: B
authors.initials: B
authors.lastname: Rudinsky
authors.forename: I
authors.initials: I
authors.lastname: Sabo
authors.forename: M
authors.initials: M
authors.lastname: Bielova
authors.forename: R
authors.initials: R
authors.lastname: Luzica
authors.forename: O
authors.initials: O
authors.lastname: Wiczmandyova
authors.forename: M
authors.initials: M
authors.lastname: Huttova
authors.forename: A
authors.initials: A
authors.lastname: Ondrusova
mesh_terms: D016009:Chi-Square Distribution; D017714:Community-Acquired Infections / Q000382:microbiology / Q000401:mortality; D003428:Cross Infection / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000145:classification; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D017063:Outcome Assessment, Health Care; D035583:Rare Diseases; D012307:Risk Factors