Therapeutic angiogenesis in cardiovascular disease.
Atherosclerotic disease of the arteries is a major cause of coronary artery disease, peripheral vascular disease and stroke. Some patients are however not candidate for the standard treatment of angioplasty or bypass surgery. Hence there is tremendous enthusiasm for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial disease. This augmentation of physiological neo-vascularization in cardiovascular disease can be achieved through different pathways. In this article we are reviewing the Use of Gene therapy, Protein therapy and cellular therapy.
Al Sabti
Hilal
H
Department of surgery, Sultan Qaboos University Hospital, Code 123, P.Box 35, Al Khod, Sultanate of Oman. alsabti@hotmail.com
D043925:Angiogenesis Inducing Agents / Q000378:metabolism / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000453:epidemiology; D001854:Bone Marrow Cells / Q000378:metabolism; D002986:Clinical Trials as Topic; D004847:Epithelial Cells / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D015316:Genetic Therapy; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D012307:Risk Factors; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D043925:Angiogenesis Inducing Agents; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors