Influence of bleaching on the enantiomeric disposition of amphetamine-type stimulants in hair.
The aim of this work was to study the influence of hair bleaching on the enantiomeric ratios of amphetamine-type stimulants (ATS), including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyethylamphetamine. Hair specimens from 14 STA users were treated with a commercial bleaching product during 40 min. After alkaline digestion and solid-phase extraction of bleached and non-bleached hair, the STA enantiomers were derivatised with an in-house synthesised chiral reagent, the (2S,4R)-N-heptafluorobutyryl-4-heptafluorobutoyloxy-prolyl chloride. The diastereoisomers were quantified by GC/MS-NCI. The results showed that the concentrations of all enantiomers decreased in bleached hair in comparison with the non-treated hair (median values between 20 and 39%). The enantiomeric ratios of the STA in bleached hair were not significantly different from those determined in non-treated hair. Our findings pointed out that bleaching treatments decrease concentrations of STA in hair without influencing their enantiomeric ratios.
Martins
Liliane Ferreira
LF
National Laboratory of Health, Toxicology Division, University of Luxembourg, 162A avenue de la Faïencerie, L-1511, Luxembourg. liliane.martins@lns.etat.lu
Yegles
Michel
M
Thieme
Detlef
D
Wennig
Robert
R
D000662:Amphetamines / Q000032:analysis* / Q000737:chemistry; D004202:Disinfectants / Q000008:administration & dosage*; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006801:Humans; D012973:Sodium Hypochlorite / Q000008:administration & dosage*; D013237:Stereoisomerism
D000662:Amphetamines; D004202:Disinfectants; D012973:Sodium Hypochlorite