[Study of anti-inflammatory activity of some organic and inorganic magnesium salts in rats fed with magnesium-deficient diet].
The purpose of the present research was comparative study of anti-inflammatory action of some Mg salts in rats fed with Mg-deficient diet. It was shown in our study that administration of Mg L-aspartate with pyridoxine leads to higher compensation of Mg deficiency in rats with diet-induced Mg depletion as compared with other Mg supplementations. According to the Mg deficiency correction rate Mg salts may be ranged in the following order: Mg L-aspartate with pyridoxine > or = Mg chloride with pyridoxine > or = Mg lactate with pyridoxine > or = Mg L-aspartate > Mg chloride > Mg orotate. In our study administration of Mg salts resulted in decreased number of blood leukocytes, reduced peripheral vasodilation visible in the external ear, decreased spleen weight, and as consequences in reduced inflammatory and immunological response. According to correction rate of the inflammatory response Mg salts may be ranged in the following order: Mg orotate > or = Mg chloride > or = Mg chloride with pyridoxine > or = Mg L-aspartate > or = MgL-aspartate with pyridoxine > or = Mg lactate with pyridoxine.
Spasov
A A
AA
Iezhitsa
I N
IN
Kravchenko
M S
MS
Kharitonova
M V
MV
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D019587:Dietary Supplements; D005526:Food, Formulated; D007249:Inflammation / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007958:Leukocyte Count; D008274:Magnesium / Q000008:administration & dosage*; D008275:Magnesium Deficiency / Q000097:blood / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D009929:Organ Size; D051381:Rats; D012492:Salts / Q000008:administration & dosage; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014664:Vasodilation / Q000187:drug effects / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012492:Salts; D008274:Magnesium