Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis.
Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The aims of this study were to determine whether oral administration of glabridin, a functional component of liquorice, could ameliorate dextran sulphate sodium (DSS)-induced colitis, as well as to understand the possible underlying mechanisms. Acute experimental colitis was induced in BALB/c mice by treatment with 5% DSS for 7 days. Glabridin (10 or 50 mg/kg/day) was given for 7 days. Treatment with glabridin significantly attenuated mortality, loss of body weight, shortening of the colon and severe clinical symptoms. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity and the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E2, and proinflammatory cytokines. These results suggest that glabridin-mediated anti-inflammatory action on colorectal sites may be a useful therapeutic approach to IBD.
Kwon
H-S
HS
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Gangwon-do, Republic of Korea.
Oh
S-M
SM
Kim
J-K
JK
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D003092:Colitis / Q000188:drug therapy* / Q000276:immunology; D003106:Colon; D016207:Cytokines / Q000032:analysis / Q000235:genetics; D016264:Dextran Sulfate; D015232:Dinoprostone / Q000032:analysis; D005260:Female; D006035:Glycyrrhiza; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology*; D007529:Isoflavones; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D018375:Neutrophil Activation / Q000187:drug effects; D009569:Nitric Oxide / Q000032:analysis; D009195:Peroxidase / Q000032:analysis; D010636:Phenols / Q000627:therapeutic use*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D015415:Biomarkers; D016207:Cytokines; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D012333:RNA, Messenger; D009569:Nitric Oxide; D016264:Dextran Sulfate; D009195:Peroxidase; C107601:glabridin; D015232:Dinoprostone