Protein translocation: checkpoint role for SRP GTPase activation.
Co-translational protein targeting by the signal recognition particle (SRP) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site. A recent study provides new insights on the link between the GTPases and protein translocation.
Bange
Gert
G
Heidelberg University Biochemistry Center (BZH), INF328, D-69120 Heidelberg, Germany.
Wild
Klemens
K
Sinning
Irmgard
I
D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D018271:Signal Recognition Particle / Q000737:chemistry / Q000502:physiology*; D013824:Thermus / Q000201:enzymology
D001426:Bacterial Proteins; D018271:Signal Recognition Particle; D020558:GTP Phosphohydrolases