Integrated endoplasmic reticulum stress responses in cancer.
The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how ER-resident molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology.
Moenner
Michel
M
Institut National de la Sante et de la Recherche Medicale, E0113, Bordeaux, France.
Pluquet
Olivier
O
Bouchecareilh
Marion
M
Chevet
Eric
E
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D011489:Protein Denaturation; D011499:Protein Processing, Post-Translational
D020533:Angiogenesis Inhibitors