title: [The value of quantitative analysis of myocardial contrast echocardiography in diagnosing coronary atherosclerotic heart disease].
abstract: This study was aimed to evaluate the quantitative analysis of MCE in diagnosing coronary atherosclerotic heart disease. MCE was performed on 10 patients with coronary artery disease. The parameters were extracted from imaging during the refilling period by time-intensity curve. SIpeak represents the peak of the signal intensity at the end of the perfusion process. Rt denotes refilling time, b indicates refilling rate. SI x b represents myocardial blood flow. SIpeak, Rt, b and SI x b showed significant differences in various segment of one patient. SIpeak exhibited significant difference between the control and observation groups (P < 0.05). The area under curve (AUC) of ROC was determined to be 0.782 and the optimum critical point was 64.4. SIpeak < or = 64.4 could predict the risk of coronary atherosclerotic heart disease with a sensitivity of 83.3% and a specificity of 69.0%. With the use of CnTI, myocardial perfusion was satisfactorily shown. The data from this initial study indicate that MCE and Qontrasts quantitative analysis software can evaluate the defect and damage area of myocardial infarction and low blood flow. SIpeak is a valuable predictor of coronary atherosclerotic heart disease.
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
authors.forename: Junmin
authors.initials: J
authors.lastname: Xie
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Man
authors.initials: M
authors.lastname: Lu
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Haibo
authors.initials: H
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003324:Coronary Artery Disease / Q000175:diagnosis*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride