Isolation and structures of erylosides from the Carribean sponge Erylus goffrilleri.
Eight new triterpene glycosides, erylosides R ( 1), S ( 2), T ( 3), U ( 4), F 5-F 7 ( 5- 7), and V ( 8), were isolated from the sponge Erylus goffrilleri collected near Arresife-Seko Reef (Cuba). Structures of 1 and 2 were determined as the corresponding monosides having aglycons related to penasterol with additional oxidation and methylation patterns in their side chains. Eryloside T ( 3) was structurally identified as the Delta (7)-isomer of 1, containing an unusual (14-->9)-lactone ring in the tetracyclic aglycon moiety, and eryloside U ( 4) was shown to be the 7,8-epoxide of 3. Erylosides F 5-F 7 ( 5- 7) and V ( 8) contain new variants of carbohydrate chains with two ( 5- 7) and three ( 8) sugar units, respectively.
Afiyatullov
Shamil Sh
SSh
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok, Russian Federation. afiyat@piboc.dvo.ru
Kalinovsky
Anatoly I
AI
Antonov
Alexandr S
AS
Ponomarenko
Ludmila P
LP
Dmitrenok
Pavel S
PS
Aminin
Dmitry L
DL
Krasokhin
Vladimir B
VB
Nosova
Valentina M
VM
Kisin
Alexandr V
AV
D000818:Animals; D017691:Caribbean Region; D003462:Cuba; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D006027:Glycosides; D014315:Triterpenes