Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.
Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non-peptidic disulfide derivative 8 significantly decreases the migration of neuroblasts from SVZ cells, and antagonized the stimulating activity of disulfide cyclic peptide 1. Discovery of compounds 1 and 8 constitutes new chemical tools which could be used to understand the mechanism of neuroblast migration during neurogenesis and eventually to identify specific genes involved in the neurogenesis.
Rolland
Amandine
A
Laboratoire de Chimie Biomoléculaire, UMR-CNRS 6216, IBDML, Université de la Méditerranée, Parc Scientifique de Luminy, case 901, 13288 Marseille cedex 9, France.
Boquet
Isabelle
I
Norreel
Jean-Chrétien
JC
Moret
Vincent
V
Laras
Younes
Y
Kraus
Jean-Louis
JL
D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D020547:Lateral Ventricles / Q000166:cytology / Q000187:drug effects; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D001372:Aza Compounds; D004220:Disulfides; D047028:Macrocyclic Compounds; D010456:Peptides, Cyclic; D011073:Polyamines