Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.
An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.
Lanver
Andreas
A
Institut für Organische Chemie, Universität zu Köln, Germany.
Schmalz
Hans-Günther
HG
D000586:Amination / Q000528:radiation effects; D002625:Chemistry, Organic / Q000379:methods; D017606:Chlorine Compounds / Q000737:chemistry / Q000528:radiation effects; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis; D008872:Microwaves; D008954:Models, Biological; D009705:Nucleosides / Q000138:chemical synthesis*; D011687:Purines / Q000737:chemistry / Q000528:radiation effects*
D017606:Chlorine Compounds; D006839:Hydrocarbons, Acyclic; D009705:Nucleosides; D011687:Purines; C079308:6-chloropurine