Circulating adipocytokines in obese nondiabetic patients in relationship with cardiovascular risk factors, anthropometry and resting-energy expenditure.
BACKGROUND
Obesity and insulin resistance are associated with cardiovascular risk factors, including altered levels of inflammatory markers and adipocytokines. The aim of the present study was to examine the relationship between circulating adipocytokines and cardiovascular risk factors.


METHODS
A population of 95 obese, nondiabetic outpatients was analyzed prospectively. A complete nutritional evaluation was performed.


RESULTS
In the multivariate analysis, with leptin as a dependent variable, only fat mass remained in the model (F = 66.6; p < 0.05), with an increase of 2.24 (95% CI 1.68-2.8) ng/ml of leptin with each 1 kg of fat mass. In a new model, with adiponectin as a dependent variable, the HDL cholesterol levels remained in the model (F = 8.46; p < 0.05), with an increase of 5.38 (95% CI 1.7-9.1) ng/ml of adiponectin with each 1 mg/dl of HDL cholesterol. In a third model, with interleukin 6 (IL-6) as a dependent variable, the resistin and C-reactive protein (CRP) levels remained in the model (F = 16.8; p < 0.01), with an increase of 0.48 (95% CI 0.27-0.85) pg/ml of IL-6 with each 1 ng/ml of resistin and an increase of 0.12 (95% CI 0.029-0.214) pg/ml with each 1 mg/dl of CRP.


CONCLUSIONS
Circulating adipocytokine concentrations are associated with different cardiovascular risk factors in nondiabetic obese patients.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medical School and Research Support Unit, Hospital Río Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
Sagrado
M Gonzalez
MG
Conde
R
R
Aller
R
R
Izaola
O
O
Romero
E
E
D054392:Adipokines / Q000097:blood*; D000328:Adult; D000886:Anthropometry; D001481:Basal Metabolism / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism; D002153:Calorimetry, Indirect; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000378:metabolism; D052243:Resistin / Q000097:blood; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D054392:Adipokines; D008076:Cholesterol, HDL; D015850:Interleukin-6; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein