title: Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.
abstract: The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.
authors.affiliation: University of Mississippi. University, Mississippi 38677-1848, USA.
authors.forename: Amar G
authors.initials: AG
authors.lastname: Chittiboyina
authors.forename: Gundluru Mahesh
authors.initials: GM
authors.lastname: Kumar
authors.forename: Paulo B
authors.initials: PB
authors.lastname: Carvalho
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhou
authors.forename: Dale G
authors.initials: DG
authors.lastname: Nagle
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Avery
mesh_terms: D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D051793:Hypoxia-Inducible Factor 1; C496938:laurenditerpenol