Pyrazolo[4,3-e][1,2,4]triazines: purine analogues with electronic absorption in the visible region.
Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10(-3) -10(-5) M range.
Mojzych
Mariusz
M
Department of Chemistry, University of Podlasie, 3-Maja 54, Siedlce, Poland.
Rykowski
Andrzej
A
Wierzchowski
Jacek
J
D000042:Absorption; D000818:Animals; D002417:Cattle; D043302:Cultured Milk Products / Q000201:enzymology; D004341:Drug Evaluation; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000201:enzymology; D006148:Guanine Deaminase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008027:Light; D008954:Models, Biological; D009132:Muscles / Q000201:enzymology; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011687:Purines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D011817:Rabbits; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
D004791:Enzyme Inhibitors; D011687:Purines; D011720:Pyrazoles; D014227:Triazines; D014969:Xanthine Oxidase; D011683:Purine-Nucleoside Phosphorylase; D006148:Guanine Deaminase