title: 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.
abstract: 2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 microg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175, Iran. sd_emami@yahoo.com
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Mehraban
authors.initials: M
authors.lastname: Falahati
authors.forename: Ensieh
authors.initials: E
authors.lastname: Lotfali
authors.forename: Saeed
authors.initials: S
authors.lastname: Rajabalian
authors.forename: Soltan-Ahmed
authors.initials: SA
authors.lastname: Ebrahimi
authors.forename: Shirin
authors.initials: S
authors.lastname: Farahyar
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000098:Acetophenones; D000935:Antifungal Agents; D001393:Azoles