Therapeutic applications of mesenchymal stromal cells.
Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an "off-the-shelf" therapeutic product.
Brooke
Gary
G
Adult Stem Cell Laboratory, Biotherapy Program, Mater Medical Research Institute, Brisbane, Queensland, Australia.
Cook
Matthew
M
Blair
Chris
C
Han
Rachel
R
Heazlewood
Celena
C
Jones
Ben
B
Kambouris
Melinda
M
Kollar
Kate
K
McTaggart
Steven
S
Pelekanos
Rebecca
R
Rice
Alison
A
Rossetti
Tony
T
Atkinson
Kerry
K
D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D039902:Multipotent Stem Cells / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology / Q000637:transplantation