Tight junction and polarity interaction in the transporting epithelial phenotype.
Development of tight junctions and cell polarity in epithelial cells requires a complex cellular machinery to execute an internal program in response to ambient cues. Tight junctions, a product of this machinery, can act as gates of the paracellular pathway, fences that keep the identity of plasma membrane domains, bridges that communicate neighboring cells. The polarization internal program and machinery are conserved in yeast, worms, flies and mammals, and in cell types as different as epithelia, neurons and lymphocytes. Polarization and tight junctions are dynamic features that change during development, in response to physiological and pharmacological challenges and in pathological situations like infection.
Cereijido
Marcelino
M
Department of Physiology, Biophysics and Neurosciences, CINVESTAV, AP 14-740, México D.F. 07000, México. cereijido@fisio.cinvestav.mx
Contreras
Rubén G
RG
Shoshani
Liora
L
Flores-Benitez
David
D
Larre
Isabel
I
D000818:Animals; D001755:Blastocyst / Q000502:physiology / Q000648:ultrastructure; D017173:Caenorhabditis elegans / Q000502:physiology / Q000648:ultrastructure; D002448:Cell Adhesion; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila / Q000502:physiology / Q000648:ultrastructure; D004847:Epithelial Cells / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D046912:Multiprotein Complexes; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure; D009504:Neutrophils / Q000502:physiology / Q000648:ultrastructure; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000502:physiology / Q000648:ultrastructure; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology / Q000648:ultrastructure; D019108:Tight Junctions / Q000502:physiology*
D008565:Membrane Proteins; D046912:Multiprotein Complexes; D000254:Sodium-Potassium-Exchanging ATPase