Fused heterocycles: synthesis of some new imidazo[1,2-a]- pyridine derivatives.
Some new thiazolidines and spirothiazolidines derived from hydrazones of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative of isoniazid, were synthesized and characterized by analytical, IR, (1)H- and (13)C-NMR and mass spectral data. Some of the newly synthesized compounds were screened for their antimycobacterial activities. None of the tested compounds showed significant in vitro antituberculous activity at 6.25 mirog/mL (MIC rifampin 0.031 microg/mL).
Kasimogullari
Birgul Ozden
BO
Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 30416, Istanbul, Turkey. okasimogullari@yahoo.com
Cesur
Zafer
Z
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000995:Antitubercular Agents; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine