title: Distribution volume as an alternative to the binding potential for sigma1 receptor imaging.
abstract: The applicability of total distribution volume (DV(t)) as an alternative to binding potential (BP) was investigated for neuroreceptor mapping by positron emission tomography (PET). BP is defined as a representative quantity of receptor density. However, for making parametric images of BP, a reference region where an aimed receptor has a very low density is assumed to exist in a target region such as the brain. Thus, if the kinetics of a radioligand for target receptors does not permit an appropriate reference region, BP imaging is unattainable. In this study, [(11)C]SA4503 PET is taken to be considered which has a high affinity to the sigma(1) receptors. Through a clinical investigation using wide ranges of physiological situations, ages, sex, diseases, and selective drug-loading conditions, DV(t) has a good linear relationship with BP, and the images can be used as a spatial distribution of sigma(1) density.
authors.affiliation: Image Analysis Team, Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan. ukimura@ieee.org
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Mika
authors.initials: M
authors.lastname: Naganawa
authors.forename: Muneyuki
authors.initials: M
authors.lastname: Sakata
authors.forename: Masatomo
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mishina
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
mesh_terms: D000328:Adult; D000368:Aged; D000718:Anatomy, Regional; D001921:Brain / Q000166:cytology / Q000000981:diagnostic imaging / Q000648:ultrastructure; D001931:Brain Mapping / Q000379:methods*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010879:Piperazines / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D011869:Radioligand Assay / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D017480:Receptors, sigma / Q000819:agonists / Q000032:analysis*; D012015:Reference Standards
chemical_list: D002250:Carbon Radioisotopes; D010879:Piperazines; D019275:Radiopharmaceuticals; D017480:Receptors, sigma; C101789:SA 4503