title: Toxicity in goats caused by oleander (Nerium oleander).
abstract: Cases of poisoning by oleander (Nerium oleander) were observed in several species, except in goats. This study aimed to evaluate the pathological effects of oleander in goats. The experimental design used three goats per group: the control group, which did not receive oleander and the experimental group, which received leaves of oleander (50 mg/kg/day) for six consecutive days. On the seventh day, goats received 110 mg/kg of oleander leaves four times at one-hourly interval. A last dose of 330 mg/kg of oleander leaves was given subsequently. After the last dose was administered, clinical signs such as apathy, colic, vocalizations, hyperpnea, polyuria, and moderate rumen distention were observed. Electrocardiogram revealed second-degree atrioventricular block. Death occurred on an average at 92 min after the last dosing. Microscopic evaluation revealed renal necrosis at convoluted and collector tubules and slight myocardial degeneration was observed by unequal staining of cardiomyocytes. Data suggest that goats appear to respond to oleander poisoning in a manner similar to other species.
authors.affiliation: Department of Animal Sciences, UFERSA-BR, Mossoró-RN, Brazil.
authors.forename: R R
authors.initials: RR
authors.lastname: Barbosa
authors.forename: J D
authors.initials: JD
authors.lastname: Fontenele-Neto
authors.forename: B
authors.initials: B
authors.lastname: Soto-Blanco
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D015511:Goat Diseases / Q000139:chemically induced*; D006041:Goats; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D030007:Nerium / Q000633:toxicity*; D018515:Plant Leaves / Q000633:toxicity; D010939:Plant Poisoning / Q000662:veterinary*