Biaryl synthesis via palladium-catalyzed aryne multicomponent coupling.
Aryl iodides have been introduced as electrophiles in the three-component Heck coupling of arynes. Following optimization studies to favor three- versus two-component coupling, the reaction proceeds in good yield to afford a variety of functionalized biaryls.
Henderson
Jaclyn L
JL
University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
Edwards
Andrew S
AS
Greaney
Michael F
MF
D002384:Catalysis; D007454:Iodides / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D007454:Iodides; D010165:Palladium