title: Phenoxydifluoromethyl substituted nitrogen heterocycles. Synthesis and heterocyclization reactions of ethyl 4,4-difluoro- 4-phenoxyacetoacetate.
abstract: Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5- benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b]pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles.
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences, Vavilov Str. 28, 119991 Moscow, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Solodukhin
authors.forename: A S
authors.initials: AS
authors.lastname: Peregudov
authors.forename: E V
authors.initials: EV
authors.lastname: Vorontsov
authors.forename: N D
authors.initials: ND
authors.lastname: Chkanikov
mesh_terms: D000090:Acetoacetates / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry
chemical_list: D000090:Acetoacetates; D006571:Heterocyclic Compounds; C526761:ethyl 4,4-difluoro- 4-phenoxyacetoacetate; D009584:Nitrogen