Biocompatibility and wettability of crystalline SiC and Si surfaces.
Crystalline silicon carbide (SiC) and silicon (Si) biocompatibility was evaluated by directly culturing three mammalian cell lines on these semiconducting substrates. Cell proliferation and adhesion quality were studied using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays and fluorescent microscopy. The reported results show that SiC is indeed a more biocompatible substrate than Si. The surface wettability of SiC and Si samples was evaluated through static contact angle measurements, which provided interesting information regarding the influence of different cleaning procedures on the SiC surfaces. The cell proliferation data are discussed in light of the contact angle measurements results. This joint analysis leads to interesting conclusions that may help to uncover the main factors that define a semiconductor's biocompatibility.
Coletti
C
C
Electrical Engineering Department, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA. camilla@eng.usf.edu
Jaroszeski
M J
MJ
Pallaoro
A
A
Hoff
A M
AM
Iannotta
S
S
Saddow
S E
SE
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry*; D017554:Carbon Compounds, Inorganic / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D003460:Crystallization / Q000379:methods; D006801:Humans; D008422:Materials Testing; D051379:Mice; D012825:Silicon / Q000737:chemistry*; D017655:Silicon Compounds / Q000737:chemistry*; D017155:Wettability
D001672:Biocompatible Materials; D017554:Carbon Compounds, Inorganic; D017655:Silicon Compounds; C022088:silicon carbide; D012825:Silicon