Role of RIP140 in metabolic tissues: connections to disease.
The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle metabolism, adipocyte and hepatocyte function, and reproduction. Recent evidence has shown that the ability of RIP140 to regulate nuclear receptor function is determined by the relative level of RIP140 expression in comparison with other cofactors, by post-translational modifications and by interactions with additional transcription factors. As a result it is becoming apparent that RIP140, via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state.
White
Roger
R
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 ONN, UK.
Morganstein
Daniel
D
Christian
Mark
M
Seth
Asha
A
Herzog
Birger
B
Parker
Malcolm G
MG
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism / Q000502:physiology*; D004702:Endocrine Glands / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear