title: Local effects of dexamethasone on immune reaction in neural transplantation.
abstract: This study was performed to see whether local injection of dexamethasone may protect the neural grafts from immunological rejection and increase the successive rate of graft. Rats with unilateral 6-hydroxydopamine lesions of the mesostriatal dopamine pathway received fetal ventral mesencephalic (FVM) cells and dexamethasone in two regions of the striatum and showed significant (P<0.001) reduction in rotational asymmetry as compared to the non-immunosuppressed group. A significantly greater number of total TH-ir cells (P<0.001) and fewer number of total GFAP -ir cells (P<0.001) and inflammatory cells were observed in the striatum of animals in immunosuppressed group than those in non-immunosuppressed group. This results indicated that local injection of dexamethasone could not only reduce the immune rejection and increase the survival grafted cell but also avoid the side effects brought by long systemic administer of immunosuppressant.
authors.affiliation: Institute of Neurosurgery, General Hospital of Navy, Beijing, China. shuangff@263.net
authors.forename: Yin
authors.initials: Y
authors.lastname: Feng
authors.forename: Tian
authors.initials: T
authors.lastname: Zengmin
authors.forename: Liu
authors.initials: L
authors.lastname: Shuang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Quanjun
authors.forename: Wang
authors.initials: W
authors.lastname: Yaming
authors.forename: Hao
authors.initials: H
authors.lastname: Qiuxing
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D016332:Fetal Tissue Transplantation / Q000276:immunology*; D006084:Graft Rejection / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008636:Mesencephalon / Q000637:transplantation*; D020734:Parkinsonian Disorders / Q000628:therapy; D011247:Pregnancy; D051381:Rats
chemical_list: D007166:Immunosuppressive Agents; D003907:Dexamethasone