Radiologic and pathologic features of a posttransplantation primary central nervous system lymphoma demonstrating Epstein-Barr virus-positive Hodgkin lymphoma.
Posttransplantation lymphoproliferative disease is the most common malignancy in T-cell immunocompromised patients and often involves extranodal sites including the central nervous system (CNS). Primary posttransplantation CNS lymphomas are rare and, accordingly, are poorly characterized. Herein, for the first time, we describe the radiologic and pathologic features of a primary CNS posttransplantation lymphoproliferative disease that reveals Epstein-Barr virus-positive Hodgkin lymphoma. The lesion showed characteristic Hodgkin-Reed Sternberg cells with a typical immunophenotype, accompanied by numerous nonneoplastic B cells and T cells demonstrating classic Hodgkin lymphoma within the brain. The 65-year-old patient was treated by reduction of immunosuppression and cerebral radiation therapy and remains in remission 18 months after the initial diagnosis.
Subklewe
Marion
M
Med. Klinik m. S. Haematologie/Onkologie, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Germany. marion.subklewe@charite.de
Anagnostopoulos
Ioannis
I
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008947:Mixed Connective Tissue Disease / Q000628:therapy; D011859:Radiography; D016539:Reed-Sternberg Cells / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D014180:Transplantation