Effects of itopride hydrochloride and ranitidine in patients with functional dyspepsia: comparison between prokinetic and acid suppression therapies.
OBJECTIVE
The effect of itopride hydrochloride or ranitidine on the health-related quality of life (HRQoL) of functional dyspepsia is not well known. Our aim was to assess the HRQoL before and after administration of itopride hydrochloride or ranitidine in patients with functional dyspepsia.


METHODS
A total of 18 functional dyspepsia patients (12 women, 6 men; mean age 52.5 y.o.) were enrolled. We determined the HRQoL using two different inquiry systems: the 36 item short form of the Medical Outcome Study Questionnaire (SF-36) and the Gastrointestinal Symptom Rating Scale (GSRS). The HRQoL was determined before administration of drug, and two, four, and eight weeks after administration of drug.


RESULTS
After administration of itopride hydrochloride, the SF-36 mental health scale and GSRS indigestion syndrome score and constipation syndrome score were significantly improved compared to before administration (p < 0.05). After the administration of ranitidine, the GSRS reflux syndrome score was significantly improved compared to before administration (p < 0.05).


CONCLUSIONS
Itopride hydrochloride would be useful for the treatment of dysmotility-type functional dyspepsia, whereas ranitidine would be beneficial for ulcer-type functional dyspepsia.
Chiba
Toshimi
T
First Department of Internal Medicine, Iwate Medical University, Morioka, Iwate, Japan. toschiba@iwate-med.ac.jp
Tokunaga
Yumi
Y
Ikeda
Keisei
K
Takagi
Ryo
R
Chishima
Raita
R
Terui
Torahiko
T
Kudara
Norihiko
N
Endo
Masaki
M
Inomata
Masaaki
M
Orii
Seishi
S
Suzuki
Kazuyuki
K
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001549:Benzamides / Q000008:administration & dosage*; D001593:Benzyl Compounds / Q000008:administration & dosage*; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011899:Ranitidine / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D000897:Anti-Ulcer Agents; D001549:Benzamides; D001593:Benzyl Compounds; C102254:itopride; D011899:Ranitidine