Catalytic enantioselective approach to the stereodivergent synthesis of (+)-lasubines I and II.
A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I and II is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asymmetric formal aza-Diels-Alder reaction between N-tosyl aldimines and Danishefsky's diene.
Mancheño
Olga García
OG
Departamento de Química OrgAnica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Arrayas
Ramón Gómez
RG
Adrio
Javier
J
Carretero
Juan C
JC
D002384:Catalysis; D008968:Molecular Conformation; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D011807:Quinolizines; C414385:lasubin I