title: The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge.
abstract: PharmGKB is a knowledge base that captures the relationships between drugs, diseases/phenotypes and genes involved in pharmacokinetics (PK) and pharmacodynamics (PD). This information includes literature annotations, primary data sets, PK and PD pathways, and expert-generated summaries of PK/PD relationships between drugs, diseases/phenotypes and genes. PharmGKB's website is designed to effectively disseminate knowledge to meet the needs of our users. PharmGKB currently has literature annotations documenting the relationship of over 500 drugs, 450 diseases and 600 variant genes. In order to meet the needs of whole genome studies, PharmGKB has added new functionalities, including browsing the variant display by chromosome and cytogenetic locations, allowing the user to view variants not located within a gene. We have developed new infrastructure for handling whole genome data, including increased methods for quality control and tools for comparison across other data sources, such as dbSNP, JSNP and HapMap data. PharmGKB has also added functionality to accept, store, display and query high throughput SNP array data. These changes allow us to capture more structured information on phenotypes for better cataloging and comparison of data. PharmGKB is available at www.pharmgkb.org.
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Hernandez-Boussard
authors.forename: Michelle
authors.initials: M
authors.lastname: Whirl-Carrillo
authors.forename: Joan M
authors.initials: JM
authors.lastname: Hebert
authors.forename: Li
authors.initials: L
authors.lastname: Gong
authors.forename: Ryan
authors.initials: R
authors.lastname: Owen
authors.forename: Mei
authors.initials: M
authors.lastname: Gong
authors.forename: Winston
authors.initials: W
authors.lastname: Gor
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Chuong
authors.initials: C
authors.lastname: Truong
authors.forename: Ryan
authors.initials: R
authors.lastname: Whaley
authors.forename: Mark
authors.initials: M
authors.lastname: Woon
authors.forename: Tina
authors.initials: T
authors.lastname: Zhou
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
mesh_terms: D016208:Databases, Factual; D005796:Genes; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D023281:Genomics; D020407:Internet; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D010641:Phenotype; D014584:User-Computer Interface
chemical_list: D004364:Pharmaceutical Preparations