title: A low-noise, wideband preamplifier for a Fourier-transform ion cyclotron resonance mass spectrometer.
abstract: FTMS performance parameters such as limits of detection, dynamic range, sensitivity, and even mass accuracy and resolution can be greatly improved by enhancing its detection circuit. An extended investigation of significant design considerations for optimal signal-to-noise ratio in an FTMS detection circuit are presented. A low noise amplifier for an FTMS is developed based on the discussed design rules. The amplifier has a gain of approximately 3500 and a bandwidth of 10 kHz to 1 MHz corresponding to m/z range of 100 Da to 10 kDa (at 7 Tesla). The performance of the amplifier was tested on a MALDI-FTMS, and has demonstrated a 25-fold reduction in noise in a mass spectrum of C(60) compared with that of a commercial amplifier.
authors.affiliation: Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 2118, USA.
authors.forename: Raman
authors.initials: R
authors.lastname: Mathur
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Knepper
authors.forename: Peter B
authors.initials: PB
authors.lastname: O'Connor
mesh_terms: D000669:Amplifiers, Electronic; D017357:Cyclotrons / Q000295:instrumentation*; D017097:Electric Impedance; D005583:Fourier Analysis; D037741:Fullerenes / Q000737:chemistry; D013058:Mass Spectrometry / Q000295:instrumentation*; D009622:Noise
chemical_list: D037741:Fullerenes