title: Creutzfeldt-Jakob disease in Mexico.
abstract: Creutzfeldt-Jakob disease (CJD) is classified within the group of transmissible spongiform encephalopathies (TSE). It is a rapidly progressive illness that affects mental functions. The average age of onset is 50 years. Various tests can help orient the clinical diagnosis, but the confirmatory test is still the post mortem analysis. The aim of this study was to describe the epidemiological, clinical and histopathological characteristics of patients diagnosed as suffering from CJD, at the National Institute of Neurology and Neurosurgery of Mexico (NINN). An observational, descriptive and transversal study was conducted. We collected information concerning these cases from the Departments of Epidemiology and Pathology, as well as the clinical charts of the patients with a diagnosis of CJD. Fifteen cases were registered of which three CJD cases were definite, five probable cases were identified, and seven were possible. The average age of the patients was 49 years. Two definite cases were female and one was male. It is important to improve the systems for surveillance of this type of disease and, furthermore, to permit greater accessibility to laboratories where the procedures necessary for supporting diagnosis can be followed.
authors.affiliation: Department of Epidemiology, National Institute of Neurology and Neurosurgery, Mexico DF, Mexico. leoravelasquez@hotmail.com
authors.forename: Leora
authors.initials: L
authors.lastname: Velásquez-Pérez
authors.forename: Daniel
authors.initials: D
authors.lastname: Rembao-Bojorquez
authors.forename: Jorge
authors.initials: J
authors.lastname: Guevara
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Guadarrama-Torres
authors.forename: Araceli
authors.initials: A
authors.lastname: Trejo-Contreras
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D005260:Female; D005843:Geography; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016019:Survival Analysis; D013997:Time Factors