Effects of recombinant IL-4delta2 on human peripheral blood mononuclears.
In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4delta2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4delta2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
Silkov
A N
AN
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Gavrilenko
V A
VA
Denisova
V V
VV
Grishina
L V
LV
Kozlov
V A
VA
Sennikov
S V
SV
D017398:Alternative Splicing; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000235:genetics / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology
C508598:IL4 protein, human; D015850:Interleukin-6; D011994:Recombinant Proteins; D015847:Interleukin-4; D007073:Immunoglobulin E