Enantioselective synthesis of (-)-pentalenene.
A short, enantioselective synthesis of (-)-pentalenene is described. Catalytic enantioselective cyclopropenation with (R,R)-Rh2(OAc)(DPTI)3 was used to set the absolute stereochemistry, and an intramolecular Pauson-Khand reaction of the resulting cyclopropenyne was used to establish the quaternary center.
Pallerla
Mahesh K
MK
Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
Fox
Joseph M
JM
D003517:Cyclopentanes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D003517:Cyclopentanes; C024646:pentalenene