title: Interaction with and cleavage of DNA by novel phenanthroline polyamine derivative.
abstract: Phenanthroline-polyamine conjugates were synthesized by cross-linking of 1,10-phenanthroline to branched polyamines. The conjugates interacted with DNA strongly, and cleaved plasmid DNA hydrolytically without any metal ions under physiological conditions. The phenanthroline-polyamine conjugates also cleaved linear 30mer DNA at the bulged-out region without metal ions under physiologic conditions.
authors.affiliation: Department of Chemistry and Chemical Biology, Graduate School of Engneering, Gunma University, 1-5-1 Tenjin-chou, Kiryu, Gunma 376-8515, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasagase
authors.forename: Takeshi
authors.initials: T
authors.lastname: Arai
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ozaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sawai
mesh_terms: D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000737:chemistry*; D006868:Hydrolysis; D010618:Phenanthrolines / Q000737:chemistry*
chemical_list: D010618:Phenanthrolines; C528363:tris(1,10-phenanthrolin-2-ylaminoethyl)amine; C528364:tris(1,10-phenanthrolin-2-ylaminopropyl)amine; D004247:DNA; D003851:Deoxyribonucleases