title: Chronic lymphocytic leukaemia genetics overview.
abstract: Although the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world-wide collaborative networks that accelerated progress has become apparent. In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy.
authors.affiliation: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. caporaso@nih.gov
authors.forename: Neil
authors.initials: N
authors.lastname: Caporaso
authors.forename: Lynn
authors.initials: L
authors.lastname: Goldin
authors.forename: Christoph
authors.initials: C
authors.lastname: Plass
authors.forename: George
authors.initials: G
authors.lastname: Calin
authors.forename: Gerald
authors.initials: G
authors.lastname: Marti
authors.forename: Steven
authors.initials: S
authors.lastname: Bauer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Raveche
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: McMaster
authors.forename: David
authors.initials: D
authors.lastname: Ng
authors.forename: Ola
authors.initials: O
authors.lastname: Landgren
authors.forename: Susan
authors.initials: S
authors.lastname: Slager
mesh_terms: D002869:Chromosome Aberrations; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology / Q000235:genetics*; D008218:Lymphocytosis / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics; D011379:Prognosis; D012334:RNA, Neoplasm / Q000235:genetics
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm