title: Thrombophilia and Legg-Calvé-Perthes disease: is it a causative factor and does it affect the severity of the disease?
abstract: Coagulation parameters were studied in a population of 118 children with Perthes disease in order to determine the possible role of thrombophilia as a causative factor for the disease and to determine if thrombophilia could affect its course. We found 27 children presenting one or more coagulation disorders. The statistical analysis concurs with previous findings of a relationship between Legg-Calvé-Perthes disease and an increased liability to thrombosis; however, no significant effect of thrombophilia on the severity of the disease could be demonstrated.
authors.affiliation: University Hospitals of Leuven, Leuven, Belgium. pierre.moens@uz.kuleuven.ac.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Moens
authors.forename: Koen
authors.initials: K
authors.lastname: Defoort
authors.forename: Anja
authors.initials: A
authors.lastname: Vancampenhout
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peerlinck
authors.forename: Guy
authors.initials: G
authors.lastname: Fabry
mesh_terms: D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications / Q000473:pathology; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000097:blood / Q000209:etiology* / Q000473:pathology*; D008297:Male; D019851:Thrombophilia / Q000097:blood / Q000150:complications* / Q000473:pathology*