Reversible control of DNA hybridization by photoresponsive ligands.
Mismatch binding ligands (MBL) can act as a molecular glue which brings two single stranded DNAs (ssDNA) together to form a double stranded DNA (dsDNA). We here demonstrate that photoresponsive MBL possessing a photochromic azobenzene chromophore can control duplex stability reversibly in response to external light stimuli. Synthesis and evaluation of a series of NCDA derivatives reveals significant correlation between the linker structures in MBLs and the molecular glue function.
Uno
Shin-Nosuke
SN
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Dohno
Chikara
C
Oku
Mika
M
Nakatani
Kazuhiko
K
D001391:Azo Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000737:chemistry* / Q000528:radiation effects; D007536:Isomerism; D008024:Ligands; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D010777:Photochemistry
D001391:Azo Compounds; D004277:DNA, Single-Stranded; D008024:Ligands; D009287:Naphthyridines; D004247:DNA