On the mechanism of reduced tabletability of granules prepared by roller compaction.
In a recent paper published in this journal, authors were perplexed by their results seemingly conflicting with our earlier findings [Sun, C.C., Himmelspach, M.W., 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J. Pharm. Sci. 95, 200-206]. After carefully reviewing the two studies, we conclude that results in the two studies are actually consistent with each other.
Sun
Changquan Calvin
CC
D002482:Cellulose / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D011208:Powders / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength; D013806:Theophylline / Q000737:chemistry
D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D002482:Cellulose; D013806:Theophylline; C109691:microcrystalline cellulose