title: Protein translocation: checkpoint role for SRP GTPase activation.
abstract: Co-translational protein targeting by the signal recognition particle (SRP) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site. A recent study provides new insights on the link between the GTPases and protein translocation.
authors.affiliation: Heidelberg University Biochemistry Center (BZH), INF328, D-69120 Heidelberg, Germany.
authors.forename: Gert
authors.initials: G
authors.lastname: Bange
authors.forename: Klemens
authors.initials: K
authors.lastname: Wild
authors.forename: Irmgard
authors.initials: I
authors.lastname: Sinning
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D018271:Signal Recognition Particle / Q000737:chemistry / Q000502:physiology*; D013824:Thermus / Q000201:enzymology
chemical_list: D001426:Bacterial Proteins; D018271:Signal Recognition Particle; D020558:GTP Phosphohydrolases