Glycopeptide dendrimers. Part I.
Glycopeptide dendrimers are branched structures containing both carbohydrates and peptides. Various classes of these compounds differing in composition and structure are mentioned, together with their practical use spanning from catalysis, transport vehicles to synthetic vaccines. The main stress is given to glycopeptide dendrimers, namely multiple antigen glycopeptides (MAGs). In MAGs, the core, branches or both are composed of amino acids or peptides. Other classes of glycodendrimers (PAMAM, polypropylene imine, cyclodextrin, calixarene, etc.) are mentioned too, but to a smaller extent. Their syntheses, physicochemical properties and biological activities are given with many examples. Glycopeptide dendrimers can be used as inhibitors of cell surface protein-carbohydrate interactions, intervention with bacterial adhesion, for studying of recognition processes, diagnostics, imaging and contrast agents, mimetics, for complexation of different cationts, as site-specific molecular delivery systems, for therapeutic purposes, as immunodiagnostics and in drug design. Biomedical applications of glycopeptide dendrimers as drug and gene delivery systems are also given.
Niederhafner
Petr
P
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Sebestík
Jaroslav
J
Jezek
Jan
J
D000818:Animals; D000941:Antigens / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D002626:Chemistry, Pharmaceutical / Q000379:methods; D050091:Dendrimers / Q000737:chemistry*; D023281:Genomics / Q000379:methods; D054794:Glycomics / Q000379:methods; D006020:Glycopeptides / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D040901:Proteomics / Q000379:methods
D000941:Antigens; D001704:Biopolymers; D002241:Carbohydrates; D050091:Dendrimers; D006020:Glycopeptides; D010455:Peptides; D047250:Calixarenes