Towards a synthesis of vigabatrin using glycal chemistry.
Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.
Boga
Sobhana B
SB
Department of Chemistry, Indian Institute of Technology, Madras, India.
Aidhen
Jaimala S
JS
Aidhen
Indrapal S
IS
D002384:Catalysis; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D020888:Vigabatrin / Q000138:chemical synthesis* / Q000737:chemistry
D020888:Vigabatrin