title: Disseminated iodine-avid lung metastases in differentiated thyroid cancer: a challenge to 124I PET.
abstract: OBJECTIVE
  This study assessed the ability of visual and quantitative 124-iodine positron emission tomography ((124)I PET) data to detect disseminated iodine-avid lung metastases (DILM) of differentiated thyroid cancer (DTC).
  
  
  METHODS
  Using "post-therapy" 131-iodine ((131)I) whole-body scintigraphy (TxWBS) and thoracic computed tomography (CT), we retrospectively divided 70 consecutive DTC patients undergoing (124)I PET dosimetry approximately 1 week before (131)I therapy into subgroups positive (n = 7) or negative (n = 63) for DILM, defined as lung metastases visible on TxWBS but not thoracic CT. To determine whether (124)I PET data could distinguish patients with versus without DILM, we compared these data with the TxWBS findings. The (124)I PET data were acquired via whole-body PET scans approximately 24 h after oral administration of (124)I, 24 +/- 2 MBq. Quantitative data comprised absolute lung (124)I activity concentrations and lung-to-background (L/B) (124)I uptake ratios.
  
  
  RESULTS
  Only 1/7 DILM-positive patients had visible disseminated lung uptake. Absolute (124)I lung uptake activities overlapped considerably between both groups and did not differ significantly (P = 0.150). Mean L/B ratios, however, differed significantly between the DILM-positive and negative groups (P < 0.001). Nevertheless, L/B ratios overlapped between the groups (0.62-1.37 versus 0.13-0.69).
  
  
  CONCLUSIONS
  Quantitative analysis of (124)I PET data using the L/B ratio is a promising tool to detect patients suspicious for DILM. However, L/B ratios overlapped between the groups to an extent that an unequivocal diagnosis based solely on this criterion was impossible in some patients. In those cases, additional diagnostic tests are necessary for diagnosis.
authors.affiliation: Department of Nuclear Medicine, University of Duisburg/Essen, Hufelandstrasse 55, Essen, Germany. lutz.freudenberg@uni-due.de
authors.forename: Lutz S
authors.initials: LS
authors.lastname: Freudenberg
authors.forename: Walter
authors.initials: W
authors.lastname: Jentzen
authors.forename: Stefan P
authors.initials: SP
authors.lastname: Müller
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
mesh_terms: D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals