[Reducing plasma homocysteic acid lowers serum C-reactive protein level in children with Kawasaki disease].
OBJECTIVE
To investigate the effect of plasma homocysteic acid (HCA) reduction on serum C-reactive protein (CRP) level in children with Kawasaki disease (KD).


METHODS
Seventy-six children with KD were divided into 2 equal groups for treatment with aspirin and IVIG, or with vitamin B6 and folic acid besides in addition to aspirin and IVIG. Serum CRP level was tested before and after the treatments, and plasma HCA level was also measured after the treatments.


RESULTS
Serum CRP level was comparable between the two groups before the treatment, but significantly reduced after vitamin B6 and folic acid treatment (7.56-/+2.94 mg/L vs 12.23-/+4.16 mg/L, P<0.05). Additional vitamin B6 and folic acid treatment significantly lowered plasma HCA level (4.56-/+1.14 micromol/L vs 7.79-/+1.79 micromol/L, P<0.05), and correlation analysis demonstrated a positive correlation between plasma HCA and serum CRP levels (r=0.697, P<0.01).


CONCLUSIONS
Lowering plasma HCA can decrease serum CRP in children with KD to enhance the therapeutic effect.
Chu
Mao-ping
MP
Department of Pediatrics, Yuying Pediatrics Hospital, Wenzhou Medical College, Wenzhou 325000, China. zhmp@wzmc.net
Rong
Xing
X
Wu
Rong-zhou
RZ
Xiang
Ru-lian
RL
Xu
Qiang
Q
Zhang
Yuan-hai
YH
D001241:Aspirin / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000188:drug therapy*; D025101:Vitamin B 6 / Q000627:therapeutic use
D016756:Immunoglobulins, Intravenous; D006710:Homocysteine; C007956:homocysteic acid; D025101:Vitamin B 6; D002097:C-Reactive Protein; D005492:Folic Acid; D001241:Aspirin