Interaction with and cleavage of DNA by novel phenanthroline polyamine derivative.
Phenanthroline-polyamine conjugates were synthesized by cross-linking of 1,10-phenanthroline to branched polyamines. The conjugates interacted with DNA strongly, and cleaved plasmid DNA hydrolytically without any metal ions under physiological conditions. The phenanthroline-polyamine conjugates also cleaved linear 30mer DNA at the bulged-out region without metal ions under physiologic conditions.
Sasagase
Takeshi
T
Department of Chemistry and Chemical Biology, Graduate School of Engneering, Gunma University, 1-5-1 Tenjin-chou, Kiryu, Gunma 376-8515, Japan.
Arai
Takeshi
T
Kuwahara
Masayasu
M
Ozaki
Hiroaki
H
Sawai
Hiroaki
H
D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000737:chemistry*; D006868:Hydrolysis; D010618:Phenanthrolines / Q000737:chemistry*
D010618:Phenanthrolines; C528363:tris(1,10-phenanthrolin-2-ylaminoethyl)amine; C528364:tris(1,10-phenanthrolin-2-ylaminopropyl)amine; D004247:DNA; D003851:Deoxyribonucleases