Conformationally-2',4'-locked Aza-ENA and carbocyclic ribo-thymidine.
AONs containing aza-ENA (1), 5-membered (2) and 6-membered (3) carbocyclic analogs of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) are both nuclease resistant and capable of eliciting RNase H response, very similar to that of the native.
Chattopadhyaya
Jyoti
J
Department of Bioorganic Chemistry, Box 581, Biomedical Centre, Uppsala University, SE-75123 Uppsala, Sweden. jyoti@boc.uu.se
D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D016914:Ribonuclease H / Q000378:metabolism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry
D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C520287:aza-ENA-thymidine; C477371:locked nucleic acid; D016914:Ribonuclease H; D013936:Thymidine