title: SUMOylation-dependent function of a T-box transcriptional repressor in Caenorhabditis elegans.
abstract: T-box transcription factors are crucial developmental regulators, and they have not previously been associated with SUMOylation. In Caenorhabditis elegans, the Tbx2 subfamily member TBX-2 (T-box protein 2) is required for anterior pharyngeal muscle development. TBX-2 interacts with SUMOylation pathway enzymes, and loss of these enzymes phenocopies tbx-2 mutants. We hypothesize that TBX-2 functions as a SUMOylation-dependent transcriptional repressor. TBX-2 contains two consensus SUMOylation sites conserved in many T-box transcriptional repressors, and we suggest that the function of these T-box factors may similarly involve SUMOylation.
authors.affiliation: Department of Biological Sciences and Laboratory for Molecular Biology, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, IL 60607, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Crum
authors.forename: P G
authors.initials: PG
authors.lastname: Okkema
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D016384:Consensus Sequence; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism / Q000502:physiology*; D020825:T-Box Domain Proteins / Q000502:physiology*
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins