title: [Effect of enalapril on diabetic rat myocardial ultrastructure].
abstract: OBJECTIVE
  To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment.
  
  
  METHODS
  Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection. Histological analysis of the left ventricular tissue was performed with transmission electron microscope 1, 3, and 5 months after establishment of diabetes.
  
  
  RESULTS
  Onset of myocardial damages was observed 1 month after the development of diabetes in the rats with gradual time-dependent exacerbation. Enalapril treatment could partially reverse the myocardial destruction in the diabetic rats.
  
  
  CONCLUSIONS
  Enalapril intervention may improve the ultrastructural pathology of the myocardium in diabetic rats, which is suggestive of the action mechanisms of angiotensin-converting enzyme inhibitors in myocardium preservation.
authors.affiliation: Emergency Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xusheng909@sina.com
authors.forename: Chun-sheng
authors.initials: CS
authors.lastname: Xu
authors.forename: Zhi-liang
authors.initials: ZL
authors.lastname: Li
authors.forename: Shi-rong
authors.initials: SR
authors.lastname: Xue
authors.forename: Quan-neng
authors.initials: QN
authors.lastname: Yan
authors.forename: Hong-chao
authors.initials: HC
authors.lastname: Wu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology*; D004656:Enalapril / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013311:Streptozocin; D004656:Enalapril