Versatile preparation of fluorescent particles based on polyphosphazenes: from micro- to nanoscale.
A series of intrinsically fluorescent hydrophobic and amphiphilic polyphosphazenes with ethyl tryptophan (EtTrp) and poly(N-isopropylacrylamide) (PNIPAAm) or poly(ethylene glycol) (PEG) as hydrophobic and hydrophilic segments, respectively, are synthesized. Depending on polymer composition and preparation procedure, particles with diameters ranging from micro- to nanoscale can be prepared successfully, which might be used as a visible tracer, both in vitro or in vivo, in drug- or gene-delivery systems, as well as in other biomedical studies such as diagnostic medicine and brain research. Most importantly, in combination with the flexible synthesis and versatile modification of polyphosphazene, this method provides a general protocol to engineer a broad range of fluorescent particles with different properties based on diverse polymers.
Zhang
Jianxiang
J
Key Laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Institute of Polymer Science, Zhejiang University, Hangzhou 310027, PR China. jxzhang1980@gmail.com
Qiu
Liyan
L
Li
Xiaodong
X
Jin
Yi
Y
Zhu
Kangjie
K
D000180:Acrylic Resins / Q000737:chemistry; D045744:Cell Line, Tumor; D005453:Fluorescence; D006801:Humans; D008823:Micelles; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D012996:Solutions; D014364:Tryptophan / Q000378:metabolism
D000180:Acrylic Resins; D008823:Micelles; D009943:Organophosphorus Compounds; D011108:Polymers; D012996:Solutions; C108974:poly(phosphazene); C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D014364:Tryptophan