title: Controlled release drug coatings on flexible neural probes.
abstract: We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating is applied to flexible polymer neural probes with platinum electrodes. The drug eluting device is implanted in one hemisphere of a rat, while a control device is implanted in the opposite hemisphere. Impedance measurements are performed to determine the effect of the drug eluting coating on the tissue reaction surrounding the probe and the electrical characteristics of the devices. Probes that are coated with drug eluting coatings show better long term impedance characteristics over control probes. These coatings can be used to increase the reliability and long term success of neural prostheses.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, EPFL, Switzerland. andre.mercanzini@epfl.ch
authors.forename: Andre
authors.initials: A
authors.lastname: Mercanzini
authors.forename: Sai
authors.initials: S
authors.lastname: Reddy
authors.forename: Diana
authors.initials: D
authors.lastname: Velluto
authors.forename: Philippe
authors.initials: P
authors.lastname: Colin
authors.forename: Anne
authors.initials: A
authors.lastname: Maillard
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Bensadoun
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bertsch
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D017097:Electric Impedance; D004567:Electrodes, Implanted; D008839:Microelectrodes; D009044:Motor Cortex / Q000502:physiology; D053758:Nanoparticles / Q000008:administration & dosage*; D010984:Platinum; D051381:Rats; D012117:Resins, Synthetic; D014025:Titanium
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D012117:Resins, Synthetic; C029945:polyimide resin; D010984:Platinum; D003907:Dexamethasone; D014025:Titanium