LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium.
LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals.
Karavolos
M H
MH
Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
Bulmer
D M
DM
Winzer
K
K
Wilson
M
M
Mastroeni
P
P
Williams
P
P
Khan
C M A
CM
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D013437:Carbon-Sulfur Lyases / Q000235:genetics / Q000378:metabolism*; D005407:Flagella / Q000737:chemistry* / Q000276:immunology; D005408:Flagellin / Q000276:immunology / Q000378:metabolism*; D017353:Gene Deletion; D005816:Genetic Complementation Test; D053038:Quorum Sensing; D012486:Salmonella typhimurium / Q000378:metabolism*
D001426:Bacterial Proteins; D005408:Flagellin; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria