Allopeptides and the alloimmune response.
The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.
Bharat
Ankit
A
Department of Surgery, Washington University School of Medicine, Box 8109-3328 CSRB, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. bharata@wudosis.wustl.edu
Mohanakumar
T
T
D000818:Animals; D017951:Antigen Presentation; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation; D006649:Histocompatibility Antigens; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology; D007519:Isoantigens / Q000276:immunology* / Q000494:pharmacology; D016030:Kidney Transplantation; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D023421:Models, Animal; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology* / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents; D007519:Isoantigens; D010455:Peptides