False-positive results on colorimetric carbon dioxide analysis in neonatal resuscitation: potential for serious patient harm.
A term infant requiring resuscitation was found to have a false-positive color change on a colorimetric carbon dioxide device as a result of administration of epinephrine via an endotracheal tube. Using models of direct application and vapor exposure with a test lung, we discovered that epinephrine, atropine, infasurf and naloxone may result in false-positive color change. This false-positive response may lead to delayed recognition of esophageal intubation.
Hughes
S M
SM
Eudowood Neonatal Pulmonary Division, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD, USA.
Blake
B L
BL
Woods
S L
SL
Lehmann
C U
CU
D000280:Administration, Inhalation; D001919:Bradycardia / Q000188:drug therapy; D002245:Carbon Dioxide / Q000032:analysis*; D003124:Colorimetry; D004837:Epinephrine / Q000008:administration & dosage*; D005189:False Positive Reactions; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D012151:Resuscitation; D013566:Sympathomimetics / Q000008:administration & dosage*
D013566:Sympathomimetics; D002245:Carbon Dioxide; D004837:Epinephrine