title: A loop resonator for slice-selective in vivo EPR imaging in rats.
abstract: A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 microT/W(1/2) was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.
authors.affiliation: Department of Electrical Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan. hhirata@yz.yamagata-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirata
authors.forename: Guanglong
authors.initials: G
authors.lastname: He
authors.forename: Yuanmu
authors.initials: Y
authors.lastname: Deng
authors.forename: Ildar
authors.initials: I
authors.lastname: Salikhov
authors.forename: Sergey
authors.initials: S
authors.lastname: Petryakov
authors.forename: Jay L
authors.initials: JL
authors.lastname: Zweier
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides; D017352:Echo-Planar Imaging / Q000295:instrumentation*; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted; D008297:Male; D019047:Phantoms, Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D013113:Spin Labels
chemical_list: D003497:Cyclic N-Oxides; D013113:Spin Labels; C047253:3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl