Studies on the synthesis and reactivity of novel benzofuran-2-yl-[3-methyl-3-phenylcyclobutyl] methanones and their antimicrobial activity.
Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described. Two of the synthesized compounds have been tested against eight different microorganisms and found to be active against some of the species studied.
Koca
Murat
M
Firat University, Faculty of Arts and Sciences, Chemistry Department, 23119 Elazig, Turkey.
Ahmedzade
Misir
M
Cukurovali
Alaaddin
A
Kazaz
Cavit
C
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry*; D003503:Cyclobutanes / Q000737:chemistry* / Q000494:pharmacology; D004249:DNA Damage; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology; D014466:Ultraviolet Rays
D000890:Anti-Infective Agents; D001572:Benzofurans; D003503:Cyclobutanes; D017705:Lignans; D010091:Oximes; D013844:Thiazoles; D013882:Thiosemicarbazones