title: Large-cell neuroendocrine carcinoma of the skin, with lymphoid stroma.
abstract: We report two cases of a large-cell neuroendocrine carcinoma of the skin as a distinct histological category. The patients are a 63-year-old woman with a 7-mm reddish round nodule on her nose for 4 months, and a 95-year-old man with several hemorrhagic nodules on the external ear for 28 months. The first patient had two positive sentinel lymph nodes. The tumors from both patients consisted of islands of pleomorphic large cells within a lymphoid stroma.
authors.affiliation: Department of Pathology, Shizuoka Cancer Center Hospital and Research Institute, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Japan. m.kasami@scchr.jp
authors.forename: Masako
authors.initials: M
authors.lastname: Kasami
authors.forename: Kouji
authors.initials: K
authors.lastname: Muramatsu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kawahata
authors.forename: Shusuke
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kiyohara
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002278:Carcinoma in Situ / Q000175:diagnosis; D018287:Carcinoma, Large Cell / Q000556:secondary*; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism / Q000648:ultrastructure; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D017154:Stromal Cells / Q000473:pathology*; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016708:Synaptophysin