title: Diffusion tensor imaging in schizophrenia: relationship to symptoms.
abstract: In this diffusion tensor imaging (DTI) study, the authors investigated white matter integrity in schizophrenia and the relationships between white matter alterations and specific symptoms of the disorder. We compared DTI images of 25 schizophrenia patients and 25 matched healthy controls and performed voxel-wise correlational analyses using the patient's DTI data and their severity scores of positive and negative symptoms. We found diffuse deficits in multiple types of white matter tracts in schizophrenia, and an inverse relationship of DTI fractional anisotropy (FA) values with positive symptom scores in association fibers, supporting a "disconnection" hypothesis of positive symptoms in schizophrenia.
authors.affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA. lskelly@harthosp.org
authors.forename: Laurie R
authors.initials: LR
authors.lastname: Skelly
authors.forename: Vince
authors.initials: V
authors.lastname: Calhoun
authors.forename: Shashwath A
authors.initials: SA
authors.lastname: Meda
authors.forename: Jinsuh
authors.initials: J
authors.lastname: Kim
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Mathalon
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D016880:Anisotropy; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods; D035061:Control Groups; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009434:Neural Pathways / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index