Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.
Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.
Watanabe
Kenatarou
K
Shibaura institute of technology, Department of applied chemistry, Toyosu 3-7-5, Koutou-ku, Tokyo 138-8548, Japan.
Katou
Toyofusa
T
Ikezawa
Yasunori
Y
Yajima
Saki
S
Shionoya
Hirohito
H
Akagi
Takashi
T
Hamasaki
Keita
K
D000617:Aminoglycosides / Q000737:chemistry*; D005601:Framycetin / Q000737:chemistry*; D016325:HIV Long Terminal Repeat; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry*
D000617:Aminoglycosides; D011687:Purines; D011743:Pyrimidines; D012367:RNA, Viral; D005601:Framycetin; C488396:neamine