Cytokinesis in trypanosomatids.
The process of cytokinesis, where the cytoplasm of one cell is divided to produce two daughter cells, is intricate in trypanosomatids because of the requirement to replicate and segregate a number of single copy organelles, including the nucleus, kinetoplast, Golgi apparatus, and flagellum. Identifying regulators of the three stages of cytokinesis, initiation, furrow ingression, and abscission is complicated by the fact that cell division in trypanosomatids is easily perturbed and aberrant cells are readily produced during functional characterization of gene products. In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model.
Hammarton
Tansy C
TC
Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom.
Monnerat
Séverine
S
Mottram
Jeremy C
JC
D000818:Animals; D048749:Cytokinesis / Q000502:physiology*; D005786:Gene Expression Regulation; D008018:Life Cycle Stages; D008855:Microscopy, Electron, Scanning; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000502:physiology / Q000648:ultrastructure; D014351:Trypanosomatina / Q000502:physiology* / Q000648:ultrastructure
D015800:Protozoan Proteins