title: Synthesis of the key precursor of Hirsutellide A.
abstract: Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
authors.affiliation: College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, PR China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Xu
authors.forename: Xuemin
authors.initials: X
authors.lastname: Duan
authors.forename: Meiling
authors.initials: M
authors.lastname: Li
authors.forename: Liqin
authors.initials: L
authors.lastname: Jiang
authors.forename: Guangle
authors.initials: G
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Meng
authors.forename: Ligong
authors.initials: L
authors.lastname: Chen
mesh_terms: D008954:Models, Biological; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis; D011498:Protein Precursors / Q000138:chemical synthesis*
chemical_list: D010456:Peptides, Cyclic; D011355:Prodrugs; D011498:Protein Precursors; C470802:hirsutellide A