Managing pain in chronic pancreatitis:therapeutic value of opioid treatment.
The value of opioid pharmacotherapy in the management of chronic pancreatitis pain is described. The role of kappa receptor opioid agonists and specifically oxycodone as compared to other opioid agonists is discussed. Limitations in the published studies on this topic are delineated as are difficulties in extrapolating form animal studies to clinical care.
Eisenberg
Elon
E
Department of Medical Gastroenterology, Medicinehuset, Aalborg, Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark.
Ståhl
Camilla
C
Drewes
Asbjørn M
AM
Arendt-Nielsen
Lars
L
D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D006801:Humans; D010098:Oxycodone / Q000494:pharmacology / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010195:Pancreatitis / Q000150:complications*; D017473:Receptors, Opioid, kappa / Q000819:agonists
D000701:Analgesics, Opioid; D017473:Receptors, Opioid, kappa; D010098:Oxycodone