[Study of toxicity effect of different rate of Sargassum and Radix Glycyrrhizae on rats].
OBJECTIVE
Study the toxicity effect of different rate of Sargassum and Radix Glycyrrhizae on rats.


METHODS
32 Wistar rats [body weight (123 +/- 15.3) g] were random divided into 4 groups of 8: normal group (A) and compatibility medicine group (B, C, D). The normal group was oral administrated with the distilled water, B, C, D group were oral given the Sargassum and Radix Glycyrrhizae (1:1), Sargassum and Radix Glycyrrhizae (1:2), Sargassum and Radix Glycyrrhizae (1:3) for 35 days, the dose was 20 mg x g(-1) weight, in the meantime, general state of health was observed, then rats were slaughtered, and the body weight, internal organs coefficient, blood routine, serum biochemistry and liver drug enzyme were assaied.


RESULTS
The rats' general state of health, body weight, internal organs coefficient has not been affected, the hemoglobin, the red blood cell, the kidney function and liver function have been affected, and has some toxic effect on the rats' white blood cell and cardic muscle, the toxic effect on cardic muscle was increase along with the rate of Sargassum and Radix Glycyrrhizae; liver drug enzyme activity has been improved.


CONCLUSIONS
The different rates of Sargassum and Radix Glycyrrhizae have some selective toxic effect on internal organs of rats.
Yan
Hui
H
School of Biology and Environment Engineering, Jiangsu University of Science and Technology, Zhenjiang 212018, China. yanh1006@163.com
Wang
Guo-ji
GJ
Chen
Jian
J
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D006035:Glycyrrhiza / Q000737:chemistry*; D006454:Hemoglobins / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000633:toxicity*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D044647:Sargassum / Q000737:chemistry*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D008419:Materia Medica; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase