title: Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor.
abstract: OBJECTIVE
  To study and compare the efficacy and side effects of drotaverine hydrochloride and hyoscine-N-butylbromide in the augmentation of labor.
  
  
  METHODS
  A prospective randomized trial of 150 women in active labor included 50 women given drotaverine (group 1), 50 women given hyoscine-N-butylbromide (group 2), and 50 women given no medication (group 3). Duration of labor, rate of cervical dilation, mode of delivery, side effects, and neonatal outcome were compared among the groups.
  
  
  RESULTS
  The mean duration of the active phase of labor was 4.48+/-2.26 h, 3.9+/-2.42 h, and 3.6+/-2.07 h in groups 1, 2, and 3, respectively. The mean rate of cervical dilation was 2.6 cm/h, 2.4 cm/h, and 2.5 cm/h, respectively. The differences were not statistically significant. There was no difference in the duration of the second and third stages of labor. No adverse maternal or fetal outcomes were noted.
  
  
  CONCLUSIONS
  Drotaverine hydrochloride and hyoscine-N-butylbromide do not have a role in augmentation of labor.
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Science, Ansari nagar, New Delhi, India. dr_bindiya_gupta@yahoo.co.in
authors.forename: Bindiya
authors.initials: B
authors.lastname: Gupta
authors.forename: Vimala
authors.initials: V
authors.lastname: Nellore
authors.forename: Suneeta
authors.initials: S
authors.lastname: Mittal
mesh_terms: D000328:Adult; D002086:Butylscopolammonium Bromide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D010208:Papaverine / Q000009:adverse effects / Q000031:analogs & derivatives*; D010276:Parasympatholytics / Q000009:adverse effects*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide; C005317:drotaverin; D010208:Papaverine