Enhanced in vitro culture of human SAOS-2 osteoblasts on a sand-blasted titanium surface modified with plastic deformation.
The titanium surfaces with micro-roughness have been studied to substitute machined titanium, with the focus on enhancing the bone apposition onto the implant. In this study we have followed a biomimetic strategy where human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a sandblasted titanium surface modified with plastic deformation. In comparison with sandblasted titanium surface, the plastic deformation increased the cell proliferation and the surface coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
Fassina
Lorenzo
L
University of Pavia, Dipartimento di Informatica e Sistemistica, Centro di Ingegneria Tissutale (C.I.T.), via Ferrata 1, 27100 Pavia, Italy. lorenzo.fassina@unipv.it
Saino
Enrica
E
Visai
Livia
L
De Angelis
Maria G
MG
Benazzo
Francesco
F
Magenes
Giovanni
G
D000537:Aluminum Oxide; D001861:Bone Regeneration; D018786:Bone Substitutes; D045744:Cell Line, Tumor; D024042:Collagen Type I / Q000378:metabolism; D004247:DNA / Q000032:analysis; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D018786:Bone Substitutes; D024042:Collagen Type I; D004247:DNA; D014025:Titanium; D000537:Aluminum Oxide