title: Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
abstract: Acquired abnormalities of coagulation and fibrinolysis in nephrotic syndrome have been implicated in the pathogenesis of deep-vein and arterial thrombosis. A mutation in the factor V and methylenetetrahydrofolate reductase (MTHFR) gene, the commonest inherited risk factor for venous thrombosis, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome. Here, we report on an arterial thrombosis in a young girl with idiopathic membranous glomerulonephritis associated with heterozygous factor V Leiden and homozygous MTHFR C677T mutation. We postulate that screening for factors such as factor V Leiden and MTHFR C677T mutation may be beneficial to patients associated with thromboembolism and idiopathic nephrotic syndrome.
authors.affiliation: Department of Pediatric Nephrology, Gaziantep University Faculty of Medicine, Sahinbey , Gaziantep 27310, Turkey. buyukcelikm66@yahoo.com
authors.forename: Mithat
authors.initials: M
authors.lastname: Büyükçelik
authors.forename: Metin
authors.initials: M
authors.lastname: Karakök
authors.forename: Osman
authors.initials: O
authors.lastname: Başpinar
authors.forename: Ayşe
authors.initials: A
authors.lastname: Balat
mesh_terms: D000293:Adolescent; D005165:Factor V / Q000235:genetics*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D009154:Mutation; D013927:Thrombosis / Q000150:complications* / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP)