title: Assembly and maintenance of the sarcomere night and day.
abstract: The assembly of sarcomeric proteins into the highly organized structure of the sarcomere is an ordered and complex process involving an array of structural and associated proteins. The sarcomere has shown itself to be considerably more complex than ever envisaged and may be considered one of the most complex macromolecular assemblies in biology. Studies over the last decade have helped to put a new face on the sarcomere, and, as such, the sarcomere is being redefined as a dynamic network of proteins capable of generating force and signalling with other cellular compartments and metabolic enzymes capable of controlling many facets of striated myocyte biology.
authors.affiliation: The Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Samuel Y
authors.initials: SY
authors.lastname: Boateng
authors.forename: Paul H
authors.initials: PH
authors.lastname: Goldspink
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm; D004734:Energy Metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism; D008958:Models, Molecular; D009124:Muscle Proteins / Q000737:chemistry / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D011487:Protein Conformation; D012518:Sarcomeres / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009124:Muscle Proteins