title: Diamond microelectrodes and CMOS microelectronics for wireless transmission of fast-scan cyclic voltammetry.
abstract: This paper reports on technology development at the sensor and circuit levels for wireless transmission of fast-scan cyclic voltammetry (FSCV) in neurochemical detection. Heavily conductive, boron-doped diamond is selectively deposited onto the polished tip of a tungsten microelectrode to fabricate versatile, implantable, micro-needle microprobes capable of neurochemical sensing in the brain. In addition, an integrated circuit is fabricated in a 0.5-microm CMOS technology for processing and wireless transmission of the electrochemical signals corresponding to extracellular concentration changes of various neurotransmitters. The chip consists of a current-based, second-order, front-end SigmaDelta ADC and an on-chip, RF-FSK transmitter at the back-end. The ADC core and the transmitter consume 22microA and 400microA, respectively, from a 2.6-V power supply. Major electroactive neurotransmitters such as serotonin and dopamine in micromolar concentration have been wirelessly recorded at 433MHz using 300-V/s FSCV in flow injection analysis experiments.
authors.affiliation: Electrical Engineering and Computer Science Department, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Masoud
authors.initials: M
authors.lastname: Roham
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Halpern
authors.forename: Heidi B
authors.initials: HB
authors.lastname: Martin
authors.forename: Hillel J
authors.initials: HJ
authors.lastname: Chiel
authors.forename: Pedram
authors.initials: P
authors.lastname: Mohseni
mesh_terms: D018130:Diamond / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004581:Electronics / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008904:Miniaturization; D018377:Neurotransmitter Agents / Q000032:analysis; D012666:Semiconductors; D012701:Serotonin / Q000032:analysis*; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D018130:Diamond