title: Characterization of breast tumors with NIR methods using optical indices.
abstract: This work describes the characterization efficiency of optical properties of breast tumors based on the features obtained using in vivo near-infrared (NIR) spectroscopy measurements. Three features, relative blood concentration, oxygen saturation and the size of the tumor, are used to diagnose benign and malignant tumors. The performance of the proposed set of features are evaluated by various classifiers using data acquired from 44 patients with malignant tumors, and 72 patients with benign tumors. The area under the receiver operating characteristics (ROC) curve of the scaled nearest mean classifier (NMSC) using the three features yields a value of 0.91 with a significance level of 0.05. Our results suggest that the features, relative blood concentration, and oxygen saturation can differentiate breast tumors with a relatively high precision.
authors.affiliation: Dept. of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
authors.forename: Burak
authors.initials: B
authors.lastname: Alacam
authors.forename: Birsen
authors.initials: B
authors.lastname: Yazici
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
authors.forename: Shoko
authors.initials: S
authors.lastname: Nioka
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D055095:Optics and Photonics; D010100:Oxygen / Q000097:blood*; D010363:Pattern Recognition, Automated / Q000379:methods*; D012031:Refractometry / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010100:Oxygen