Recent insights into the biology of Hodgkin lymphoma: unraveling the mysteries of the Reed-Sternberg cell.
The microscopic pathology of Hodgkin lymphoma has been recognized for well over a century; however, only in the past 15 years has the enigmatic nature of this peculiar neoplasm been somewhat unraveled. This has been accomplished via a combination of the acquisition, via microdissection, of the prototypically rare malignant cells and their subsequent analysis via a variety of modalities, including genomic studies and expression profiling. This has facilitated the elucidation of the surreptitiously concealed B-cell origin of the cells, their complex but vital relationships with the surrounding micro- and macroenvironment, as well as multiple pathways involved in the pathobiology of this lymphoma. Understanding the intricacies of these intra- and extracellular pathways should allow for the development of less-toxic targeted therapies.
Roullet
Michele R
MR
University of Pennsylvania, Department of Pathology & Laboratory Medicine, 6.093 Founders Pavilion, 3400 Spruce Street, PA 19104-4283, USA. roulletm@uphs.upenn.edu
Bagg
Adam
A
D004854:Herpesvirus 4, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism; D010641:Phenotype; D016539:Reed-Sternberg Cells / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D016328:NF-kappa B