T-cell death and cancer immune tolerance.
Cancer patients mount adaptive immune responses against their tumors. However, tumor develops many mechanisms to evade effective immunosurveillance. T-cell death caused by tumor plays a critical role in establishing tumor immunotolerance. Chronic stimulation of T cells by tumors leads to activation-induced cell death. Abortive stimulation of T cells by tolerogenic antigen-presenting cells loaded with tumor antigens leads to autonomous death of tumor-specific T cells. Therapeutic approaches that prevent T-cell death in the tumor microenvironment and tumor draining lymph nodes, therefore, should boost adaptive immune responses against cancer.
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Department of Immunology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA. Binfeng@pitt.edu
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D000951:Antigens, Neoplasm / Q000276:immunology; D017209:Apoptosis; D001343:Autophagy; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007157:Immunologic Surveillance; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013491:Suppressor Factors, Immunologic / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000502:physiology; D019139:Tumor Escape
D000951:Antigens, Neoplasm; D013491:Suppressor Factors, Immunologic