title: Selective antitumor activity of lymphokine-activated killer cells in vitro.
abstract: We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).
authors.affiliation: Laboratory of Cell-Mediated Immunity, N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
authors.forename: O S
authors.initials: OS
authors.lastname: Zhukova
authors.forename: O V
authors.initials: OV
authors.lastname: Lebedinskaya
authors.forename: I Zh
authors.initials: IZh
authors.lastname: Shubina
authors.forename: G K
authors.initials: GK
authors.lastname: Gerasimova
authors.forename: A M
authors.initials: AM
authors.lastname: Karamzin
authors.forename: M V
authors.initials: MV
authors.lastname: Kiselevskii
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D006801:Humans; D016130:Immunophenotyping; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology