New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY).
Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected.
Baró
Cristina
C
Department Biologia Animal, Vegetal i Ecologia, Unitat d'Antropologia Biològica, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. cbaro@imim.es
Salido
Marta
M
Espinet
Blanca
B
Astier
Laura
L
Domingo
Alicia
A
Granada
Isabel
I
Millà
Fuensanta
F
Carrió
Ana
A
Costa
Dolors
D
Luño
Elisa
E
Hernández
Jesús Ma
JM
Campo
Elias
E
Florensa
Lourdes
L
Ferrer
Ana
A
Salar
Antonio
A
Bellosillo
Beatriz
B
Besses
Carles
C
Serrano
Sergi
S
Solé
Francesc
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005803:Genes, Immunoglobulin; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6; D013160:Splenic Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6