title: [Contrast enhanced power Doppler in evaluating the angiogenesis in hepatocellular carcinoma].
abstract: OBJECTIVE
  To evaluate the role of contrast enhanced power Doppler in evaluating tumor angiogenetic activity.
  
  
  METHODS
  Thirty-two patients with hepatocellular carcinoma were analysed. Flow signals of hepatocellular carcinoma were observed by power Doppler imaging after the injection of contrast agent, and then the relative perfusion rate and blood flow were assessed. The microvessel density (MVD) and vascular endothelial growth factor(VEGF) were assessed by immunohistochemical method. The relationship between the relative perfusion rate,blood flow, MVD,VEGF was studied.
  
  
  RESULTS
  The relative perfusion rate in the tissues with positive expression of VEGF was significantly higher than that in the tissues with negative expression of VEGF in hepatocellular carcinoma. There was correlation between the relative perfusion rate, blood flow grade and MVD(P<0.05). The expression of VEGF was positively related to the relative perfusion rate and blood flow grade(P<0.05).
  
  
  CONCLUSIONS
  Contrast enhanced power Doppler is useful in evaluating the tumor angiogenetic activity.
authors.affiliation: Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ji-dong
authors.initials: JD
authors.lastname: Xiao
authors.forename: Shou-rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Rui-zhen
authors.initials: RZ
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Zhu
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D018608:Ultrasonography, Doppler / Q000379:methods
chemical_list: D003287:Contrast Media