title: [Aprotinin reduces bleeding during off-pump coronary artery bypass grafting in a patient on ticlopidine; report of a case].
abstract: A 65-year-old man was admitted to a local hospital with symptoms of unstable angina pectoris. He was administered ticlopidine before drug eluting stent (DES) stenting for 2 weeks. Coronary angiography showed 3 vessel diseases. He was then admitted to our hospital due to a sudden onset of unstable angina following shock during the percutaneous coronary intervention (PCI) procedure, emergency off-pump coronary artery bypass grafting (OPCAB) was thus performed. He received aprotinin 5 hundred thousand KIU just at the start of surgery and 5 hundred thousand KIU after undergoing anastomosis of the coronary artery. Postoperatively, only some minor bleeding was observed. Aprotinin reduces bleeding, the transfusion requirements of packed red blood cells, platelets, and the total blood units in patients on ticlopidine who undergo emergency OPCAB.
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Iwahashi
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
authors.forename: N
authors.initials: N
authors.lastname: Morishige
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashida
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Teshima
authors.forename: G
authors.initials: G
authors.lastname: Kuwahara
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000601:surgery*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D007611:Aprotinin / Q000008:administration & dosage*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D047549:Coronary Artery Bypass, Off-Pump; D054855:Drug-Eluting Stents; D004630:Emergencies; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*
chemical_list: D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D007611:Aprotinin; D013988:Ticlopidine