Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure.
We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca(2+)-ATPase, phospholamban, beta1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca(2+)-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the beta1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca(2+)-ATPase and beta1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
Kovlen
D V
DV
Department of Balneology and Physiotherapy, S. M. Kirov Military Medical Academy, St. Petersburg. denis.kovlen@mail.ru
Tishakov
A Yu
AY
Glotov
O S
OS
Moskalenko
M V
MV
Demin
G S
GS
Bitsadze
A N
AN
Chernyshev
A V
AV
Bratova
N I
NI
Ivashchenko
T E
TE
Obrezan
A G
AG
Ponomarenko
G N
GN
D000368:Aged; D002135:Calcium-Binding Proteins / Q000235:genetics; D000252:Calcium-Transporting ATPases / Q000235:genetics; D002908:Chronic Disease; D002980:Climate; D005260:Female; D006294:Health Resorts; D006333:Heart Failure / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics; D016138:Walking; D000099211:Phospholamban
D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D007334:Insulin-Like Growth Factor I; D018342:Receptors, Adrenergic, beta-1; D000099211:Phospholamban