Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case.
Diffuse infiltrative lymphocytosis syndrome (DILS) is an uncommon manifestation of HIV infection characterised by persistent circulating CD8+ lymphocytosis accompanied by visceral lymphocytic infiltration. The lungs and the salivary glands are the most common organs involved. Parotid enlargement in HIV-seropositive subjects may represent HIV-associated lymphoepithelial lesions, hyperplastic lymphadenopathy, lymphoma, bacterial and viral infections, Sjögren's syndrome and DILS. Therefore confirmatory histopathological diagnosis and immunohistochemical analysis following a biopsy is essential to determine the exact nature of the salivary gland enlargement. A review of the literature of DILS and a description of a typical case of bilateral cystic lymphoepithelial lesions of the parotid glands, in an HIV-seropositive subject with DILS, is presented.
Feller
L
L
Department of Periodontology and Oral Medicine, Box D26, Faculty of Dentistry, University of Limpopo, Medunsa Campus 0204, South Africa. lfeller@medunsa.ac.za
White
J P
JP
Bouckaert
M
M
Muthuphei
M N
MN
D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications; D006801:Humans; D018655:Lymphocyte Count; D008218:Lymphocytosis / Q000209:etiology*; D008297:Male; D010305:Parotid Diseases / Q000209:etiology; D013577:Syndrome