Synthesis of benzoxazinone derivatives: a new route to 2 (N phthaloylmethyl)-4H-3,1-benzoxazin-4-one.
A new method has been designed to prepare the known benzoxazinone derivative 2-(N-phthaloylmethyl)-4H-3,1-benzoxazin-4-one (4). The acyl chloride derivative N-phthaloylglycine reacts with anthranilic acid in chloroform, in the presence of triethylamine, to give an intermediate that is then reacted with cyanuric chloride, used as a cyclization agent, to produce the benzoxazinone derivative.
Shariat
Mehdi
M
Department of Chemistry, Payamnoor University of Golpayegan, Golpayegan, Iran.
Abdollahi
Sohrab
S
D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry
C525073:2-(N phthaloylmethyl)-4H-3,1-benzoxazin-4-one; D048588:Benzoxazines