title: Quantum chemical and experimental studies on the mechanism of alkylation of beta-dicarbonyl compounds. The synthesis of five and six membered heterocyclic spiro derivatives.
abstract: The alkylation of beta-dicarbonyl compounds in a K2CO3/DMSO system was found to afford O- and C-alkylated derivatives, depending on the type of the beta-dicarbonyl compound involved. The alkyl derivatives obtained were used in the synthesis of some new spiro barbituric acid derivatives. Quantum chemical calculations were carried out to elucidate the reaction mechanisms for some typical synthesis.
authors.affiliation: Baku St. University, Faculty of Chemistry, Department of Organic Chemistry, Baku, Azerbayijan.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Sadikov
authors.forename: Sahin
authors.initials: S
authors.lastname: Nasibov
authors.forename: Cemil
authors.initials: C
authors.lastname: Oğretir
authors.forename: Halil
authors.initials: H
authors.lastname: Berber
authors.forename: Ali
authors.initials: A
authors.lastname: Hüseyinli
mesh_terms: D000478:Alkylation; D001463:Barbiturates / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D001463:Barbiturates; D006571:Heterocyclic Compounds; D013141:Spiro Compounds; D002244:Carbon; C032232:barbituric acid