title: Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline.
abstract: A case of osteomyelitis caused by multidrug-resistant Pseudomonas aeruginosa is reported in a patient who underwent allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. The patient was successfully treated by prolonged administration of a full dose of colistin and tigecycline, and surgical curettage with the positioning of resorbable calcium sulfate pellets loaded with colistin.
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Stanzani
authors.affiliation: Division of Infectious Diseases, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Tumietto
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Maria Benedetta
authors.initials: MB
authors.lastname: Giannini
authors.affiliation: Rizzoli Orthopaedic Institutes, 5th Division, University of Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bianchi
authors.affiliation: Department of Clinical and Experimental Medicine, Section of Microbiology S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Nanetti
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Vianelli
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Arpinati
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Giovannini
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bonifazi
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bandini
authors.affiliation: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Baccarani
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003091:Colistin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D000078304:Tigecycline; D014184:Transplantation, Homologous
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline; D003091:Colistin