No relation between angiotensin-converting enzyme gene polymorphism and pseudoexfoliation.
OBJECTIVE
To determine the association between the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism and pseudoexfoliation (PEX) in Turkish patients.


METHODS
This prospective study consisted of 89 patients with PEX, and 120 controls. The I/D polymorphism of the angiotensin-converting enzyme gene was measured with the use of the polymerase chain reaction method.


RESULTS
The distribution of the polymorphism was not significantly different in cases with PEX and controls. The frequencies of the I and D alleles were not significantly different between the groups.


CONCLUSIONS
According to our findings, I/D polymorphism in the angiotensin-converting enzyme gene does not play any role in the pathogenesis of PEX.
Tekeli
Oya
O
Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey. oyatekeli@tr.net
Turaçli
M Erol
ME
Altinok
Buket
B
Akar
Nejat
N
Elhan
Atilla Halil
AH
D000368:Aged; D004251:DNA Transposable Elements; D017889:Exfoliation Syndrome / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A