Nocturnal cardiac arrhythmia in patients with obstructive sleep apnea.
OBJECTIVE
Nocturnal cardiac arrhythmias occur in patients with obstructive sleep apnea (OSA), reportedly as a consequence of the autonomic effects of recurrent apnea with subsequent oxygen desaturation. We have investigated whether different patterns of OSA are associated with specific arrhythmia during sleep.


METHODS
Electrocardiographic (ECG) data recorded during polysomnography (PSG) were analysed in 257 consecutive OSA patients to determine the prevalence of cardiac rhythm disturbances, and to relate these to breathing pattern (normal, apnea/hypopnea, recovering ventilation, snoring) and oxygen saturation.


RESULTS
Arrhythmias were found in 18.5% of patients. Patients with nocturnal bradyarrhythmia (BA) had higher values of ventilatory disturbance (apnea-hypopnea index [AHI] 58.8+/-36.8 vs 37.2+/-30.3, p=0.02), mean desaturation amplitude (8.9+/-4 vs 5.9+/-3.4%, p=0.03), and a lower SaO(2) nadir (69% vs 77%, p=0.003) than those without arrhythmia. The prevalence of BA in patients with AHI>or=30/h was significantly higher than that observed in those with AHI<30/h (7.8% vs 1.5%, respectively; chi(2)=5.61, p=0.01). In contrast, patients with tachyarrhythmia (TA) had no significant differences in AHI, mean desaturation amplitude or SaO(2) nadir than those without arrhythmia. No associations were found between arrhythmia and the presence of comorbidity or concomitant medical therapy, except for an association between tachyarrhythmia and chronic obstructive pulmonary disease (COPD) (odds ratio 2.53; 95% confidence intervals 1.1-5.8, p=0.03).


CONCLUSIONS
We conclude that while BA during sleep is associated with OSA severity, concomitant COPD or beta(2)-treatment may play a role in the development of TA during sleep.
Olmetti
Francesca
F
Divisione di Cardiologia, Istituto Scientifico di Montescano, Fondazione S. Maugeri, IRCCS, Pavia, Italy.
La Rovere
Maria Teresa
MT
Robbi
Elena
E
Taurino
Anna Eugenia
AE
Fanfulla
Francesco
F
D000318:Adrenergic beta-Agonists / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D012913:Snoring / Q000503:physiopathology
D000318:Adrenergic beta-Agonists; D010100:Oxygen