Atropisomeric phosphinines: design and synthesis.
The first atropisomeric phosphinine was designed and prepared by introducing substituents into specific positions of the heterocyclic framework; the presence of axial chirality was predicted by means of DFT calculations and experimentally verified by chiral HPLC analysis, derivatization experiments as well as temperature dependent 31P{1H} NMR spectroscopy.
Müller
Christian
C
Schuit Institute of Catalysis, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. c.mueller@tue.nl
Pidko
Evgeny A
EA
Totev
Daniel
D
Lutz
Martin
M
Spek
Anthony L
AL
van Santen
Rutger A
RA
Vogt
Dieter
D
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011789:Quantum Theory; D013237:Stereoisomerism
D001555:Benzene Derivatives; D009943:Organophosphorus Compounds; C519090:phosphinine