Targeting the Plasmodium vivax Duffy-binding protein.
Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.
Chitnis
Chetan E
CE
Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. cchitnis@icgeb.res.in <cchitnis@icgeb.res.in>
Sharma
Amit
A
D000818:Animals; D000913:Antibodies, Protozoan / Q000378:metabolism; D000953:Antigens, Protozoan / Q000276:immunology / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D004375:Duffy Blood-Group System / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D006801:Humans; D016780:Malaria, Vivax / Q000378:metabolism / Q000517:prevention & control*; D016790:Plasmodium knowlesi / Q000378:metabolism; D010966:Plasmodium vivax / Q000502:physiology*; D015800:Protozoan Proteins / Q000276:immunology / Q000378:metabolism*; D016052:Protozoan Vaccines; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*
C473745:ACKR1 protein, human; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D018925:Chemokines; D004375:Duffy Blood-Group System; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011956:Receptors, Cell Surface