2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.
2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 microg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.
Emami
Saeed
S
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175, Iran. sd_emami@yahoo.com
Foroumadi
Alireza
A
Falahati
Mehraban
M
Lotfali
Ensieh
E
Rajabalian
Saeed
S
Ebrahimi
Soltan-Ahmed
SA
Farahyar
Shirin
S
Shafiee
Abbas
A
D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000098:Acetophenones; D000935:Antifungal Agents; D001393:Azoles