PCNASUMO and Srs2: a model SUMO substrate-effector pair.
Attachment of the SUMO (small ubiquitin-related modifier) to the replication factor PCNA (proliferating-cell nuclear antigen) in the budding yeast has been shown to recruit a helicase, Srs2, to active replication forks, which in turn prevents unscheduled recombination events. In the present review, I will discuss how the interaction between SUMOylated PCNA and Srs2 serves as an example for a mechanism by which SUMO modulates the properties of its targets and mediates the activation of downstream effector proteins.
Ulrich
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Cancer Research UK, Clare Hall Laboratories, London Research Institute, South Mimms EN6 3LD, U.K. helle.ulrich@cancer.org.uk
D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics / Q000378:metabolism*
D018809:Proliferating Cell Nuclear Antigen; D029701:Saccharomyces cerevisiae Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; C061376:SRS2 protein, S cerevisiae; D004265:DNA Helicases