Pertussis and respiratory syncytial virus infections.
During the winter 2005-2006, all infants <4 months of age admitted for bronchiolitis or acute respiratory tract infection in a tertiary care pediatric hospital in Paris were tested for respiratory syncytial virus (RSV) and pertussis with real-time polymerase-chain reaction (RT-PCR). A positive pertussis-PCR was found in 14/90 (16%) infants infected with RSV and in 5/30 negative for RSV. Similar clinical symptoms were found in all RSV-positive infants with or without pertussis co-infection. Most infants (73%) were not vaccinated against pertussis, and the other children had received one or two injections. In conclusion, pertussis-RSV co-infection is common in young infants, and pertussis-PCR should be used, whenever available.
Cosnes-Lambe
Cécile
C
Department of Pediatric and Emergency, Université Paris 5, APHP, Hôpital Saint Vincent de Paul-Cochin, Paris, France.
Raymond
Josette
J
Chalumeau
Martin
M
Pons-Catalano
Charlotte
C
Moulin
Florence
F
de Suremain
Nathalie
N
Reglier-Poupet
Hélène
H
Lebon
Pierre
P
Poyart
Claire
C
Gendrel
Dominique
D
D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D010297:Paris / Q000453:epidemiology; D010567:Pertussis Vaccine / Q000008:administration & dosage; D015995:Prevalence; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000453:epidemiology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014917:Whooping Cough / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D010567:Pertussis Vaccine