Effect of classic convulsants on Cl- conductance of the GABA(A) receptor complex in membranes of cerebral cortex cells at the early stage of kindling.
Muscimol-stimulated Cl- conductance of synaptoneurosomes from the cerebral cortex of Wistar rats increased during the early stage of pharmacological kindling not inducing the seizure response in animals. Picrotoxin, bicuculline, and pentylenetetrazole potentiated inhibition of muscimol-dependent 36Cl- entry into synaptoneurosomes, which attested to increased sensitivity of the GABA(A) receptor/Cl- ionophore complex to classic convulsants.
Rebrov
I G
IG
Laboratory of Epileptogenesis, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Karpova
M N
MN
Andreev
A A
AA
Kalinina
M V
MV
Klishina
N Yu
NY
Kuznetsova
L V
LV
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D018118:Chloride Channels / Q000502:physiology*; D003292:Convulsants / Q000494:pharmacology*; D004357:Drug Synergism; D058785:GABA-A Receptor Agonists; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008566:Membranes; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology*; D013574:Synaptosomes / Q000502:physiology
D001640:Bicuculline; D018118:Chloride Channels; D003292:Convulsants; D058785:GABA-A Receptor Agonists; D009118:Muscimol; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011963:Receptors, GABA-A