title: [In vivo/in vitro evaluation of Kangfuxin colon targeting capsules].
abstract: OBJECTIVE
  To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro.
  
  
  METHODS
  The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo.
  
  
  RESULTS
  After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours.
  
  
  CONCLUSIONS
  Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.
authors.affiliation: Chengdu University of Traditional Chinanese Medicine, Chengdu 611730, China.
authors.forename: Xue-lan
authors.initials: XL
authors.lastname: Qiu
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Xing-liang
authors.initials: XL
authors.lastname: Xie
authors.forename: Juan
authors.initials: J
authors.lastname: Lai
authors.forename: Si-wei
authors.initials: SW
authors.lastname: Chen
mesh_terms: D000818:Animals; D002214:Capsules; D003106:Colon / Q000000981:diagnostic imaging / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010526:Periplaneta / Q000737:chemistry; D011096:Polygalacturonase / Q000737:chemistry; D011859:Radiography
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008419:Materia Medica; D011096:Polygalacturonase