Chronic lymphocytic leukaemia genetics overview.
Although the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world-wide collaborative networks that accelerated progress has become apparent. In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy.
Caporaso
Neil
N
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. caporaso@nih.gov
Goldin
Lynn
L
Plass
Christoph
C
Calin
George
G
Marti
Gerald
G
Bauer
Steven
S
Raveche
Elizabeth
E
McMaster
Mary Lou
ML
Ng
David
D
Landgren
Ola
O
Slager
Susan
S
D002869:Chromosome Aberrations; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology / Q000235:genetics*; D008218:Lymphocytosis / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics; D011379:Prognosis; D012334:RNA, Neoplasm / Q000235:genetics
D035683:MicroRNAs; D012334:RNA, Neoplasm