ESCRT-I part II: forming the real ESCRT-I complex.
Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I component that shapes ESCRT-I into an elongated structure and affects HIV-1 morphogenesis.
Weissenhorn
Winfried
W
Unit for Virus Host Cell Interaction, UMR 5233 University Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France. weissenhorn@embl.fr
Göttlinger
Heinrich
H
D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D015497:HIV-1 / Q000254:growth & development; D009024:Morphogenesis; D011956:Receptors, Cell Surface / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
D056827:Endosomal Sorting Complexes Required for Transport; C517100:Mvb12 protein, S cerevisiae; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins