title: Early neuropsychological dysfunction in elderly high-risk patients after on-pump and off-pump coronary bypass surgery.
abstract: OBJECTIVE
  Advanced age is associated with systemic atherosclerosis and is a risk factor for neurological dysfunction after coronary artery bypass grafting (CABG). However, few studies have investigated early neurological dysfunction after off-pump CABG in elderly patients.
  
  
  METHODS
  Data were collected prospectively on 218 patients (>/=60 years) who underwent elective off-pump (n = 89) or on-pump CABG (n = 129). Four cognitive tests were performed preoperatively and 1 week postoperatively. Neuropsychological (NP) dysfunction was defined as a decrease in an individual's performance in more than two tests of at least 20% from baseline. We compared the incidence of NP dysfunction, stroke, graft patency grading, and systemic atherosclerosis between patients who underwent off-pump and on-pump CABG.
  
  
  RESULTS
  Off-pump patients were more likely to have a history of cerebrovascular disease, peripheral vascular disease, smoking, multiple cerebral infarctions, and severe aortic atherosclerosis. None of the off-pump and three on-pump patients suffered intraoperative strokes (P = 0.27). The incidence of NP dysfunction was 11.2% in the off-pump group and 22.5% in the on-pump group, (P = 0.02). Multivariate analysis revealed that NP dysfunction was associated with cardiopulmonary bypass (CPB) and multiple cerebral infarctions. The off-pump group had fewer vessels grafted (2.4 vs 3.4; P < 0.01), and a higher rate of stenosis (>50%) and occlusion of the grafted vessels (13.0% vs 7.4%; P = 0.01) than the on-pump group.
  
  
  CONCLUSIONS
  Off-pump CABG reduced postoperative NP dysfunction in elderly patients with severe systemic atherosclerosis compared to on-pump CABG.
authors.affiliation: Department of Anesthesiology, Kumamoto Chuo Hospital, 1-5-1 Tainoshima, Kumamoto, 862-0965, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Baba
authors.forename: Tomoko
authors.initials: T
authors.lastname: Goto
authors.forename: Kengo
authors.initials: K
authors.lastname: Maekawa
authors.forename: Asuka
authors.initials: A
authors.lastname: Ito
authors.forename: Atushi
authors.initials: A
authors.lastname: Yoshitake
authors.forename: Takaaki
authors.initials: T
authors.lastname: Koshiji
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000209:etiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D003072:Cognition Disorders / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D020521:Stroke / Q000209:etiology*