Chronic medication use and inflammatory skin diseases: the power and limitations of the case-control study.
The potential of newly introduced medications to cause acute inflammatory skin diseases has long been recognized. Less well accepted and not often systematically studied is the role of long-term drug use in inflammatory skin diseases such as eczema. Hypothesis-driven case-control studies provide what is probably the most efficient but far from easy method to evaluate and quantify observations from case reports and case series that suggest a drug etiology for chronic skin diseases.
Stern
Robert S
RS
Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. rstern@bidmc.harvard.edu
D016022:Case-Control Studies; D002908:Chronic Disease; D003880:Dermatology / Q000295:instrumentation / Q000379:methods*; D004485:Eczema / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D016017:Odds Ratio; D012107:Research Design; D012189:Retrospective Studies; D012871:Skin Diseases / Q000188:drug therapy / Q000276:immunology*; D013997:Time Factors