Making oligonucleotide conjugates and breaking oligonucleotides.
Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups. Recent results on cleavage of RNA by artificial nucleases, is also presented.
Milton
S
S
Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
Murtola
M
M
Sandbrink
J
J
Yeheskiely
E
E
Strömberg
R
R
D002219:Carbamates / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry*
D002219:Carbamates; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012260:Ribonucleases