title: Predictors for acute and chronic pouchitis following restorative proctocolectomy for ulcerative colitis.
abstract: OBJECTIVE
  This study was undertaken to evaluate the cumulative incidence, onset and risk predicting factors for acute and chronic pouchitis.
  
  
  METHODS
  A consecutive series of patients (n = 210), who underwent restorative proctocolectomy (RPC) and had a minimum follow-up of 12 months was reviewed. The cumulative incidence and onset of pouchitis was determined. Univariate analysis, followed by logistic regression analysis was used to evaluate the association of various demographic, clinical and histopathologic variables with the subsequent development of acute and chronic pouchitis.
  
  
  RESULTS
  A total of 198 patients were included. The mean follow-up was 64 months (range, 12-180). Sixty-four patients (32%) developed pouchitis, 35 acute and 29 chronic. The first episode of pouchitis occurred within the first year in 70% of cases. The presence of backwash ileitis (OR, 2.6; P = 0.015), primary sclerosing cholangitis (PSC; OR, 2; P = 0.018) and the duration of follow-up (OR, 1.1; P = 0.043) were associated with a higher incidence of pouchitis. The duration of follow-up was the only variable associated with acute pouchitis (P = 0.007). The presence of backwash ileitis and PSC were independent risk factors for chronic pouchitis (OR, 5.9; P < 0.001; OR, 2.8; P = 0.001 respectively).
  
  
  CONCLUSIONS
  Pouchitis is a heterogeneous disease which tends to occur early after restoration of gastrointestinal continuity. Patients with backwash ileitis and/or PSC are at considerable risk of developing chronic pouchitis. The strong association between backwash ileitis, PSC and chronic pouchitis suggests a common link in their pathogenesis.
authors.affiliation: Department of General Surgery, York Hospital, York, UK. aymonrazeq@yahoo.co.uk
authors.forename: A S
authors.initials: AS
authors.lastname: Abdelrazeq
authors.forename: N
authors.initials: N
authors.lastname: Kandiyil
authors.forename: I D
authors.initials: ID
authors.lastname: Botterill
authors.forename: J N
authors.initials: JN
authors.lastname: Lund
authors.forename: J R
authors.initials: JR
authors.lastname: Reynolds
authors.forename: P J
authors.initials: PJ
authors.lastname: Holdsworth
authors.forename: S H
authors.initials: SH
authors.lastname: Leveson
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D002908:Chronic Disease; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D019449:Pouchitis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D015995:Prevalence; D011336:Probability; D016737:Proctocolectomy, Restorative / Q000009:adverse effects* / Q000379:methods; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D055815:Young Adult