title: Effectiveness of Lanzhou lamb rotavirus vaccine against rotavirus gastroenteritis requiring hospitalization: a matched case-control study.
abstract: We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one or more doses of LLR vaccine with 95% confidence intervals (CI). For one dose versus zero doses, LLR vaccine VE was 73.3% (95% CI, range 61.2-81.6%). VE of one dose versus zero doses was higher in children 12-23 months than in children 2-11 months (80.9% versus 60.0%). We found one dose moderately effective in preventing rotavirus gastroenteritis requiring hospitalization.
authors.affiliation: Guangzhou Centre for Disease Control and Prevention, Guangzhou, China.
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Fu
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liang
authors.forename: Tongjie
authors.initials: T
authors.lastname: He
authors.forename: Dahu
authors.initials: D
authors.lastname: Wang
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Xu
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D005759:Gastroenteritis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology*
chemical_list: D022243:Rotavirus Vaccines