Kadsuralignans H-K from Kadsura coccinea and their nitric oxide production inhibitory effects.
One new arylnaphthalene lignan named kadsuralignan H ( 1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I ( 2), J ( 3), and K ( 4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (INF-gamma).
Li
Heran
H
College of Pharmacy, Nihon University, Funabashi, Chiba, Japan.
Wang
Liyan
L
Yang
Zhigang
Z
Kitanaka
Susumu
S
D000818:Animals; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D010946:Plants, Medicinal / Q000737:chemistry*
D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; D008070:Lipopolysaccharides; C510994:dibenzocyclooctadiene lignan; D009569:Nitric Oxide; D007371:Interferon-gamma