[Neuronal connections of ocular dominance columns in the cortex of monocularly deprived cats].
We have investigated the developmental changes of intrahemispheric neuronal connections of the areas 17 & 18 ocular dominance columns in monocularly deprived cats. Single cortical columns were microiontophoretically injected with horseradish peroxidase and 3D reconstruction of retrogradely labelled cells' region was done. Ocular dominance of injected columns and their coordinates in the visual field map were determined. In area 17 it was shown that for non-deprived eye the connections of columns that are driven via the crossed pathways were longer than connections of columns driven via uncrossed ones, and in both cases they were longer than connections in intact cats. The connections of deprived eye columns are significantly reduced. We have observed some changes in the spatial organization of long-range connections in area 17 for columns driven by the non-deprived eye (more rounded shape of regions of labeled cells, non-uniform distribution of cells within it). Maximal length of such connections did not exceed the length of connections in strabismic cats. We speculate that the length of cell axons providing for the horizontal connections of cortical columns has some intrinsic limit that does not depend on visual stimulation during the critical period of development.
Alekseenko
S V
SV
Toporova
S N
SN
Shkorbatova
P Iu
PIu
D000818:Animals; D002415:Cats; D023882:Dominance, Ocular / Q000502:physiology*; D006735:Horseradish Peroxidase; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D015349:Vision, Monocular / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*
D006735:Horseradish Peroxidase