A small molecular scaffold for selective inhibition of Wip1 phosphatase.
Bang
Jeong
J
Laboratory of Cell Biology, NCI, Bethesda, MD 20892, USA.
Yamaguchi
Hiroshi
H
Durell
Stewart R
SR
Appella
Ettore
E
Appella
Daniel H
DH
D020134:Catalytic Domain; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D010766:Phosphorylation; D000071636:Protein Phosphatase 2C; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D004791:Enzyme Inhibitors; D011758:Pyrroles; D016159:Tumor Suppressor Protein p53; D048051:p38 Mitogen-Activated Protein Kinases; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C