Self-expanding metallic stents for gastric outlet obstruction resulting from stomach cancer: a preliminary study with a newly designed double-layered pyloric stent.
BACKGROUND
Although endoscopic stent placement is now generally accepted as a palliative treatment for gastric outlet obstruction resulting from gastric cancer, it carries potential limitations such as tumor ingrowth or migration.


OBJECTIVE
Our purpose was to evaluate the technical and clinical efficacy of endoscopic placement of a newly designed double-layered combination pyloric stent.


METHODS
Prospective, uncontrolled, single-center.


METHODS
Tertiary referral university hospital.


METHODS
Eleven patients with gastric outlet obstruction by unresectable stomach cancer.


METHODS
Eleven patients received a double-layered combination pyloric stent (an outer uncovered stent to reduce migration and an inner polytetrafluoroethylene-covered stent to prevent tumor ingrowth).


METHODS
To evaluate technical success, clinical success, and complications, especially tumor ingrowth and migration.


RESULTS
Technical success was achieved in 11 of 11 (100%) patients. Among 11 patients in whom endoscopic stenting was placed successfully, clinical success was 90.9%, tumor ingrowth 0%, migration 9.1%, and tumor overgrowth 9.1%. Median stent patency period was 121 days.


CONCLUSIONS
Small number of patients, uncontrolled study, short-term follow-up period.


CONCLUSIONS
We have described a technique for endoscopic metal stent placement by using the newly designed double-layered combination stent for gastric outlet obstruction by stomach cancer. This stent seems to be effective and looks promising for technical efficacy, clinical outcome, and preventing tumor ingrowth and migration.
Lee
Sun Mi
SM
Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
Kang
Dae Hwan
DH
Kim
Gwang Ha
GH
Park
Won Il
WI
Kim
Hyong Wook
HW
Park
Jin Hong
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D017219:Gastric Outlet Obstruction / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents / Q000639:trends*; D013274:Stomach Neoplasms / Q000150:complications*; D016896:Treatment Outcome