title: Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.
abstract: Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease.
authors.affiliation: Nathan S. Kline Institute, Orangeburg, New York 10962, USA.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Mi
authors.forename: Monika
authors.initials: M
authors.lastname: Pawlik
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sastre
authors.forename: Sonia S
authors.initials: SS
authors.lastname: Jung
authors.forename: David S
authors.initials: DS
authors.lastname: Radvinsky
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Klein
authors.forename: John
authors.initials: J
authors.lastname: Sommer
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Schmidt
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Nixon
authors.forename: Paul M
authors.initials: PM
authors.lastname: Mathews
authors.forename: Efrat
authors.initials: E
authors.lastname: Levy
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D019943:Amino Acid Substitution; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D055316:Cystatin C; D015891:Cystatins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D017354:Point Mutation
chemical_list: D016564:Amyloid beta-Protein Precursor; C525030:CST3 protein, human; C525031:Cst3 protein, mouse; D055316:Cystatin C; D015891:Cystatins