title: Clinical use of Doppler echocardiography and Doppler tissue imaging in the estimation of myocardial ischemia during dobutamine stress echocardiography.
abstract: BACKGROUND
  The ratio of mitral inflow early diastolic velocity (E) to annulus velocity (E') might be critical for the assessment of an abnormal filling pressure for patients with myocardial ischemia.
  
  
  OBJECTIVE
  We sought to determine whether a quantitative estimation of E/E' provides more reliable information for detecting coronary artery disease during dobutamine stress echocardiography.
  
  
  METHODS
  A total of 82 patients suggested to have angina pectoris underwent Doppler studies during dobutamine stress echocardiography. The value of E and E' were measured at baseline and peak dose of dobutamine stress. The value of E/E' during stress over that at rest was defined as the E/E' index.
  
  
  RESULTS
  Patients who had significant stenosis by coronary angiogram were classified as being in group A (n = 45) and those with no coronary artery disease were classified as being in group B (n = 37). Dobutamine infusion led to a significant increase of E/E' in group A, whereas no changes were found with group B. Likewise, larger E/E' index was also observed for patients with multivessel disease. The value of E/E' index increased proportionally with the number of stenotic vessels, implying a direct correlation of the E/E' value to the extent of myocardial ischemia.
  
  
  CONCLUSIONS
  E/E' offers a quantitative estimation of myocardial ischemia during dobutamine stress echocardiography, thereby, providing a reliable and accurate method for the evaluation of coronary artery disease.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Higashisumisyoshi Morimoto Hospital, Osaka, Japan. hyodo@msic.med.osaka-cu.ac.jp
authors.forename: Eiichi
authors.initials: E
authors.lastname: Hyodo
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hirata
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirose
authors.forename: Kimio
authors.initials: K
authors.lastname: Kamimori
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D004280:Dobutamine; D015150:Echocardiography, Doppler / Q000379:methods*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014665:Vasodilator Agents; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D014665:Vasodilator Agents; D004280:Dobutamine