Resolved: in minimizing kidney transplant immunosuppression, steroids should go before calcineurin inhibitors: pro.
Without direct comparison or randomized controlled trials, two experts square off on the difficult choice of trying to reduce the usage of one of two drugs with well-known side effects after kidney transplantation.
Matas
Arthur J
AJ
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. matas001@umn.edu
D065095:Calcineurin Inhibitors; D004334:Drug Administration Schedule; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D011241:Prednisone / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013256:Steroids / Q000378:metabolism / Q000627:therapeutic use*; D019172:Transplantation Conditioning / Q000379:methods
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D013256:Steroids; D011241:Prednisone