Synthesis of C8-alkylamino substituted 2'-deoxyguanosine.
Synthesis of C8-alkynyl- and alkylamino substituted 2'-deoxyguanosine is described. Protected alkynylamines are coupled with 8-bromo-2'-deoxyguanosine by a Pd(0)-mediate Sonogashira coupling protocol. Hydrogenation of alkynyl derivatives over 10% Pd/C under atmospheric pressure gave 8-alkylamino guanosine derivatives in nearly quantitative yields.
Saito
Yoshio
Y
Department of Marerials Chemistry and Engineering, School of Engineering, and NEWCAT Institute, Graduate school of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan. saito@chem.ce.nihon-u.au.jp
Matsumoto
Katsuhiko
K
Bag
Subhendu Sekhar
SS
Ogasawara
Shinji
S
Suzuka
Isamu
I
Saito
Isao
I
D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015345:Oligonucleotide Probes / Q000737:chemistry
D015345:Oligonucleotide Probes; D003849:Deoxyguanosine