Impact of interleukin-10 polymorphisms (-1082 and -3575) on the survival of patients with lymphoid neoplasms.
OBJECTIVE
Single-nucleotide polymorphisms (SNP) in interleukin-10 (IL-10) genes can influence immune responses, which may affect the outcome of patients with lymphoid neoplasms. The aim of this study was to explore the association between polymorphisms of IL-10-(1082A>G) and IL-10-(3575T>A) with the overall survival in patients with lymphoid neoplasms.


METHODS
We analyzed two IL-10 SNP (-1082 and -3575) in 472 consecutive cases with lymphoid neoplasms. Genotypes were tested for association with overall survival and classical prognostic factors by multivariate analysis. Haplotype analysis was carried out using the haplostats package implemented in R software. The implications for survival of patients with lymphoma were evaluated using multivariate analysis.


RESULTS
Lymphoma patients with the IL-10-(3575T>A) genotype had a better overall survival (p= 0.002), as did the subgroup with non-Hodgkin's lymphoma (NHL) (p=0.05). Patients with the IL10(-1082GG) genotype had a better median overall survival (p=0.05). When both genotypes were included in a multivariate analysis, IL-10(-3575AA) genotype was the only independent prognostic factor for survival (HR=0.20, 95%CI 0.05-0.92). Patients with the IL-10(-1082) and (-3575) G-A/G-A diplotype had a longer overall survival (p=0.003) and this combination appeared to be an independent prognostic factor for survival (HR:0.26; 95%CI 0.08-0.83).


CONCLUSIONS
The IL-10(-3575A/A) genotype was identified as a marker of favorable survival. Because the IL-10(-1082) and (-3575) G-A/G-A diplotype was also identified as an indicator of longer survival, we cannot exclude the potential additive role of the IL-10(-1082GG) genotype. These results need to be replicated in larger series and examined in different NHL subtypes.
Domingo-Domènech
Eva
E
Department of Hematology, Institut Català d'Oncologia, Avda. Gran Via s/n, km 2.7, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. edomigo@iconcologia.net
Benavente
Yolanda
Y
González-Barca
Eva
E
Montalban
Carlos
C
Gumà
Josep
J
Bosch
Ramón
R
Wang
Sophia S
SS
Lan
Qing
Q
Whitby
Denise
D
Fernández de Sevilla
Alberto
A
Rothman
Nathaniel
N
de Sanjosé
Sílvia
S
D016022:Case-Control Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008223:Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013030:Spain; D015996:Survival Rate
D016753:Interleukin-10