Synthesis, spectroscopic and thermal characterization of some transition metal complexes of folic acid.
Compounds having general formula: [M(FO)(Cl)x(H2O)y]x zH2O, where (M=Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), FO=folate anion, x=2 or 4, y=2 or 4 and z=0, 1, 2, 3, 5 or 15) were prepared. The obtained compounds were characterized by elemental analysis, infrared as well as electronic spectra, thermogravimetric analysis and the conductivity measurements. The results suggested that all folate complexes were formed by 2:1 molar ratio (metal:folic acid) as a bidentate through both of the two carboxylic groups. The molar conductance measurements proved that the folate complexes are electrolytes. The kinetic thermodynamic parameters such as: E*, DeltaH*, DeltaS* and DeltaG* were estimated from the DTG curves. The antibacterial evaluation of the folic acid and their complexes was also done against some Gram positive/negative bacteria as well as fungi.
El-Wahed
M G Abd
MG
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Refat
M S
MS
El-Megharbel
S M
SM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D004583:Electrons; D005492:Folic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006112:Gravitation; D007700:Kinetics; D008280:Magnetics; D008670:Metals / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D013057:Spectrum Analysis; D013237:Stereoisomerism; D013696:Temperature
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D002614:Chelating Agents; D008670:Metals; D005492:Folic Acid