title: Transgenic parasites: improving our understanding of innate immunity to malaria.
abstract: Clinical immunity to Plasmodium falciparum malaria takes years to develop and is never complete. One explanation for these observations is that antigenic variation enables malaria parasites to evade humoral immunity; another is that P. falciparum induces immune dysregulation, which inhibits the development of protective cellular immunity. Research described by D'Ombrain et al. in this Cell Host & Microbe issue probes how the parasite's main virulence factor PfEMP-1 might significantly alter human innate immune responses.
authors.affiliation: Laboratory of Malaria and Vector Research, NIAID/NIH, Bethesda, MD 20892, USA. rfairhurst@niaid.nih.gov
authors.forename: Rick M
authors.initials: RM
authors.lastname: Fairhurst
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000276:immunology*; D000953:Antigens, Protozoan / Q000235:genetics; D004910:Erythrocyte Membrane; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000037:antagonists & inhibitors*; D016778:Malaria, Falciparum / Q000276:immunology*; D018448:Models, Immunological; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum; D007371:Interferon-gamma