Cilia biology: stop overeating now!
Knocking out primary cilia of adult mouse tissues or a specific subset of cilia from POMC-expressing neurons in the brain initiates uncontrolled eating. This behavior leads to obesity and kidney disease.
Satir
Peter
P
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA. satir@aecom.yu.edu
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D002696:Chlamydomonas / Q000166:cytology / Q000502:physiology; D002923:Cilia / Q000473:pathology / Q000502:physiology*; D006963:Hyperphagia / Q000209:etiology / Q000401:mortality / Q000473:pathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000209:etiology / Q000401:mortality / Q000473:pathology