cAMP response element binding protein (CREB) overexpression CREB has been described as critical for leukemia progression.
CREB has been described as critical for leukemia progress. We investigated CREB expression in ALL and AML pediatric patients. CREB protein was significantly high (p<0.001) at diagnosis but not during remission. This study underlines the role of CREB in leukemia and suggests new insights into the transformation process.
Pigazzi
Martina
M
Ricotti
Emanuela
E
Germano
Giuseppe
G
Faggian
Diego
D
Aricò
Maurizio
M
Basso
Giuseppe
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002877:Chromosomes, Human / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged
D017362:Cyclic AMP Response Element-Binding Protein