title: Annotation, comparison and databases for hundreds of bacterial genomes.
abstract: The multitude of bacterial genome sequences being determined has opened up a new field of research, that of comparative genomics. One role of bioinformatics is to assist biologists in the extraction of biological knowledge from this data flood. Software designed for the analysis and functional annotation of a single genome have, in consequence, evolved towards comparative genomics tools, bringing together the information contained in numerous genomes simultaneously. This paper reviews advances in the development of bacterial annotation and comparative analysis tools, and progress in the design of novel database structures for the integration of heterogeneous biological information.
authors.affiliation: CNRS UMR8030, Génomique Métabolique, 2 rue Gaston Crémieux, 91057 Evry Cedex, France. cmedgue@genoscope.cns.fr
authors.forename: Claudine
authors.initials: C
authors.lastname: Médigue
authors.forename: Ivan
authors.initials: I
authors.lastname: Moszer
mesh_terms: D000465:Algorithms; D001419:Bacteria / Q000145:classification / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D016680:Genome, Bacterial; D023281:Genomics; D011381:Programming Languages; D012985:Software Design