title: Assisted reproduction treatment in severe myasthenia gravis.
abstract: OBJECTIVE
  To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Tertiary infertility center.
  
  
  METHODS
  A 40-year-old woman affected by severe MG.
  
  
  METHODS
  Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia.
  
  
  METHODS
  Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG.
  
  
  RESULTS
  A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed.
  
  
  CONCLUSIONS
  This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART.
authors.affiliation: Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Institute of Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy. ricci@burlo.trieste.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ricci
authors.forename: Michela
authors.initials: M
authors.lastname: De Santis
authors.forename: Gloria
authors.initials: G
authors.lastname: Pagnini
authors.forename: Leo Fischer
authors.initials: LF
authors.lastname: Tamaro
authors.forename: Elena
authors.initials: E
authors.lastname: Giolo
authors.forename: Secondo
authors.initials: S
authors.lastname: Guaschino
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000628:therapy*; D009157:Myasthenia Gravis / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome