Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome.
OBJECTIVE
To determine the effect of metformin pretreatment on in vitro maturation (IVM) in the patients with clomiphene citrate-resistant polycystic ovary syndrome.


METHODS
Prospective randomized study.


METHODS
University affiliated hospital.


METHODS
Fifty-six women with clomiphene citrate-resistant polycystic ovary syndrome underwent 70 cycles of IVM treatment.


METHODS
Metformin was administered at a dose of 500 mg twice per day for 12 weeks before IVM treatment.


METHODS
The number of immature oocytes, oocyte maturation, fertilization, cleavage, high-quality embryo, and clinical pregnancy rates.


RESULTS
A significantly higher high-quality embryo rate (37.8%) was obtained in the metformin-treated group compared with the control group (24.3%). Accordingly, the clinical pregnancy and implantation rates were significantly higher in the metformin-treated group (38.2% and 15.3%) than the control group (16.7% and 6.2%).


CONCLUSIONS
Pretreatment with metformin improves IVM outcome in terms of embryo quality and clinical pregnancy rate as well as implantation rate.
Wei
Zhaolian
Z
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China.
Cao
Yunxia
Y
Cong
Lin
L
Zhou
Ping
P
Zhang
Zhiguo
Z
Li
Jun
J
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000150:complications / Q000188:drug therapy*; D008687:Metformin / Q000008:administration & dosage*; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011292:Premedication / Q000379:methods*; D016896:Treatment Outcome
D007004:Hypoglycemic Agents; D008687:Metformin