title: Niphatoxin C, a cytotoxic tripyridine alkaloid from Callyspongia sp.
abstract: As part of our studies to discover P2X 7 receptor antagonists, the sponge Callyspongia sp. was investigated. A new tripyridine alkaloid niphatoxin C ( 1) was isolated and had P2X 7 receptor antagonism; however, cytotoxicity of THP-1 cells was the predominant biological effect at higher concentrations. Its structure was determined by 1- and 2-D NMR spectroscopy.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Rama
authors.initials: R
authors.lastname: Addepalli
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000470:Alkaloids / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047128:Callyspongia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009000:Monocytes / Q000187:drug effects; D058919:Purinergic P2 Receptor Antagonists; D011726:Pyridinium Compounds / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D058486:Receptors, Purinergic P2X7
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C546468:P2RX7 protein, human; D058919:Purinergic P2 Receptor Antagonists; D011726:Pyridinium Compounds; D058486:Receptors, Purinergic P2X7; C527031:niphatoxin C