title: Synthesis of some new 4,5-substituted-4H-1,2,4-triazole-3-thiol derivatives.
abstract: In this study appropriate hydrazide compounds, furan-2-carboxylic acid hydrazide (1) and phenylacetic acid hydrazide (2) were converted into 1,4-substituted thiosemicarbazides 4a-e and 5a-e and 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The 1,4-substituted thiosemicarbazides were then converted into 5-(furan-2-yl or benzyl)-4-(aryl)-4H-1,2,4-triazole-3-thiols 8a-e and 9a-e. In addition, the azomethines 11a-d and 12a-d were prepared from the corresponding arylaldehydes and the 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The structures of all the synthesized compounds were confirmed by elemental analyses, IR, (1)H-NMR and(13) C-NMR spectra.
authors.affiliation: Department of Chemistry, Faculty of Science, Firat University, 23119, Elaziğ, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Cansiz
authors.forename: M
authors.initials: M
authors.lastname: Koparir
authors.forename: A
authors.initials: A
authors.lastname: Demirdağ
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D006540:Herbicides / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D005663:Furans; D006540:Herbicides; D006834:Hydrazines; D010648:Phenylacetates; D013438:Sulfhydryl Compounds; D014230:Triazoles; C025136:phenylacetic acid; C060089:2-furoic acid