Effect of plant extracts on trans-sialidase activity in human blood plasma.
We studied the effects of plant extracts and products of their biological treatment on trans-sialidase activity in human blood plasma. Extracts of kelp, fucus, yarrow, Saint John's wort, onion, and honey in vitro decreased trans-sialidase activity. Extracts of pollen (beebread) and garlic powder produced the maximum inhibitory effect. trans-Sialidase activity of blood plasma ex vivo decreased 2-fold after peroral administration of pollen and garlic powder. A correlation was found between the decrease in trans-sialidase activity in blood plasma and ability of blood plasma to induce cholesterol accumulation in cultured cells from the intact human aortic intima.
Aksenov
D V
DV
Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, Moscow. denaks@mail.ru
Kaplun
V V
VV
Tertov
V V
VV
Sobenin
I A
IA
Orekhov
A N
AN
D001011:Aorta / Q000166:cytology; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D056890:Eukaryota / Q000737:chemistry; D006023:Glycoproteins / Q000097:blood*; D006722:Honey; D006801:Humans; D009439:Neuraminidase / Q000097:blood*; D010936:Plant Extracts / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry; D017539:Tunica Intima / Q000378:metabolism
D006023:Glycoproteins; D010936:Plant Extracts; D002784:Cholesterol; C069715:trans-sialidase; D009439:Neuraminidase