title: [Study of a detection strategy for silent ischemia in diabetic patients: 18 month follow-up of the ARCADIA register].
abstract: BACKGROUND
  The prognostic impact of a myocardial ischemia-based therapeutic program in asymptomatic diabetic patients remains controversial. We prospectively assessed the benefit of a stratification algorithm based upon clinical and myocardial perfusion imaging (MPI) data on cardiovascular events in such patients in a non-randomized register.
  
  
  METHODS
  701 consecutive asymptomatic diabetic patients were classified to be at low or intermediate-to-high cardiac risk according to 13 simple boil-clinical parameters. Intermediate-to-high risk patients were scheduled for MPI and underwent either a conventional (Group 1, n=180) or an intensive multifactorial (Group 2, n=245) therapeutic program. Low risk patients (Group 3, n=276) underwent no specific management.
  
  
  RESULTS
  At the end of the survey and as a consequence of intensive management, lipid lowering therapy, antiplatelet drugs, and beta-blockers were more often prescribed in Group 2 than in Group 1 (55, 31 and 17% versus 36, 23, and 8% respectively, p<0.01). Planned coronary angiography in case of severe ischemia on MPI and revascularization were more frequent in Group 2 (16.2 and 8.9%) than in Group 1 (8.0 and 2.8% - p<0.01). At 19-month follow-up (96.7% completed), major event rate in Group 2 was significantly lower than in Group 1 (3.9 versus 9.8%, p<0.01) and similar to that of Group 3 (2.2%, NS).
  
  
  CONCLUSIONS
  Easy-to-perform risk stratification is able to select diabetic patients with good medium-term prognosis. In clinically selected higher risk patients, an intensive medical therapy combined with coronary angiography +/- revascularization in case of large ischemia on MPI is effective to improve prognosis.
authors.affiliation: Clinique de cardiologie, CHU de Grenoble, BP 217-38043 Grenoble cedex 9. gvanzetto@chu-grenoble.fr
authors.forename: G
authors.initials: G
authors.lastname: Vanzetto
authors.forename: S
authors.initials: S
authors.lastname: Halimi
authors.forename: O
authors.initials: O
authors.lastname: Ormezzano
authors.forename: J
authors.initials: J
authors.lastname: Steidel
authors.forename: L
authors.initials: L
authors.lastname: Belle
authors.forename: R
authors.initials: R
authors.lastname: Boizel
authors.forename: D
authors.initials: D
authors.lastname: Fagret
authors.forename: J
authors.initials: J
authors.lastname: Machecourt
mesh_terms: D000368:Aged; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D006331:Heart Diseases / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D012042:Registries; D012307:Risk Factors