title: Greater habitual soyfood consumption is associated with decreased carotid intima-media thickness and better plasma lipids in Chinese middle-aged adults.
abstract: Many clinical studies have shown high-dose supplemental soy protein has beneficial effects on cardiovascular risk factors. We examined the association between habitual soyfood intake and carotid intima-media thickness (IMT) and plasma lipids in a cross-sectional study including 406 (M 134, F 272) middle-aged Chinese adults (40-65 years) without confirmed relevant diseases. We found significantly dose-respondent decreases in bifurcation IMT, total and LDL cholesterol associated with increased usual soyfood intake after adjusting for potential confounders (p for trend, all p<0.05). Covariate-adjusted mean bifurcation IMT, total and LDL cholesterol decreased by 9.4%, 6.2% and 10.4% in women (p=0.020, 0.035, 0.110), 16.0%, 12.3% and 19.6% in men (p=0.036, 0.005, 0.002), and 9.9%, 9.3% and 15.4% in total men and women combined (p=0.010, <0.001, <0.001) when the mean intake of soy protein increased from 0.87 (F) or 0.64 (M) g/day (1st tertile) to 8.35 (F) or 7.48 (M) g/day (3rd tertile), respectively. Significant interaction between sex and soy consumption on bifurcation IMT was observed (p=0.008). In conclusion, higher habitual soyfood consumption is associated with decreased bifurcation IMT, plasma TC and LDL-c in middle-aged Chinese adults. The association is more apparent in men than in women.
authors.affiliation: Faulty of Nutrition, School of Public Health, Sun Yat-sen University, 74# Zhongshan Road 2, Guangzhou 510080, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Li-li
authors.initials: LL
authors.lastname: Huang
authors.forename: Xiao-xing
authors.initials: XX
authors.lastname: Zhou
authors.forename: Chao-gang
authors.initials: CG
authors.lastname: Chen
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Ye
authors.forename: Yi-xiang
authors.initials: YX
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002318:Cardiovascular Diseases / Q000517:prevention & control; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013025:Glycine max; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D008055:Lipids