Synthesis of DNA duplexes containing complexes of 5-modified pyrimidine bases and metal ions.
DNA duplexes carrying metal ions at the 5-position of uracil residues were synthesized by mixing oligodeoxyribonucleotides (ODNs) containing 5-formyl uracils, metal ions, and amines. A metal ion binding site may form from the 5-formyl residue and amines.
Iwamoto
Kenji
K
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama-shi, Kanagawa-ken 221-8686 Japan.
Hayashi
Kosei
K
Watanabe
Yuko
Y
Okamoto
Itaru
I
Ono
Akira
A
D020029:Base Pairing; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry
D007477:Ions; D008670:Metals; D009838:Oligodeoxyribonucleotides; C007777:5-formyluracil; D014498:Uracil; D004247:DNA