Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity.
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.
Di Cristo
Graziella
G
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11734, USA.
Chattopadhyaya
Bidisha
B
Kuhlman
Sandra J
SJ
Fu
Yu
Y
Bélanger
Marie-Claude
MC
Wu
Cai Zhi
CZ
Rutishauser
Urs
U
Maffei
Lamberto
L
Huang
Z Josh
ZJ
D000367:Age Factors; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D003423:Critical Period, Psychological; D005074:Evoked Potentials, Visual / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D012683:Sensory Deprivation / Q000502:physiology; D012794:Sialic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology; D014793:Visual Cortex / Q000254:growth & development; D014795:Visual Pathways / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000779:Anesthetics, Local; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; C021319:polysialic acid; D049452:Green Fluorescent Proteins; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D006026:Glycoside Hydrolases; C090534:endo-alpha-sialidase; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2