An efficient protocol for the solid-phase synthesis of malondiamides.
A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries.
Vögtle
Markus M
MM
Novartis Institutes for BioMedical Research, WSJ-507, CH-4002 Basel, Switzerland.
Marzinzik
Andreas L
AL
D003958:Diamide / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
D008314:Malonates; D011108:Polymers; D003958:Diamide; D009584:Nitrogen