New pancreas from old: microregulators of pancreas regeneration.
MicroRNAs (miRNAs) are 18-22 nucleotide RNA molecules that mediate post-transcriptional gene silencing, primarily by binding to the 3' untranslated region of their target mRNA. Several studies have demonstrated the role of miRNAs in mouse pancreas development (miR-124a, miR-503, miR-541, miR-214) as well as in insulin secretion (miR-375, miR-9). Pancreatic transcription factors that are temporally expressed during early pancreas development are re-expressed during pancreas regeneration following pancreatectomy in mice. The only exception to this is Neurogenin3 (NGN3). Here, we discuss recent evidence for miRNA-mediated silencing of ngn3, which inhibits endocrine cell development via the classical 'stem cell pathway' during mouse pancreatic regeneration, thereby favoring beta-cell regeneration.
Joglekar
Mugdha V
MV
Stem Cells and Diabetes Section, Lab 10, National Center for Cell Science, Ganeshkhind Road, Pune 411007, India.
Parekh
Vishal S
VS
Hardikar
Anandwardhan A
AA
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics; D010179:Pancreas / Q000502:physiology*; D012038:Regeneration; D014157:Transcription Factors / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C407737:Neurog3 protein, mouse