title: Control of protein translation by phosphorylation of the mRNA 5'-cap-binding complex.
abstract: Initiation of mRNA translation is a key regulatory step in the control of gene expression. Microarray analysis indicates that total mRNA levels do not always reflect protein levels, since mRNA association with polyribosomes is necessary for protein synthesis. Phosphorylation of translation initiation factors offers a cost-effective and rapid way to adapt to physiological and environmental changes, and there is increasing evidence that many of these factors are subject to multiple regulatory phosphorylation events. The present article focuses on the nature of reversible phosphorylation and the function of the 5'-cap-binding complex in plants.
authors.affiliation: Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, U.K.
authors.forename: O A
authors.initials: OA
authors.lastname: Pierrat
authors.forename: V
authors.initials: V
authors.lastname: Mikitova
authors.forename: M S
authors.initials: MS
authors.lastname: Bush
authors.forename: K S
authors.initials: KS
authors.lastname: Browning
authors.forename: J H
authors.initials: JH
authors.lastname: Doonan
mesh_terms: D010448:Peptide Initiation Factors / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D010944:Plants / Q000235:genetics / Q000378:metabolism; D039381:RNA Cap-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D010448:Peptide Initiation Factors; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger