Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Song
Eun Young
EY
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-Gu, Daejeon, Republic of Korea.
Kaur
Navneet
N
Park
Mi-Young
MY
Jin
Yinglan
Y
Lee
Kyeong
K
Kim
Guncheol
G
Lee
Ki Youn
KY
Yang
Jee Sun
JS
Shin
Jae Hong
JH
Nam
Ky-Youb
KY
No
Kyoung Tai
KT
Han
Gyoonhee
G
D000577:Amides / Q000138:chemical synthesis*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D014508:Urea / Q000138:chemical synthesis*
D000577:Amides; D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D014508:Urea; D019908:Proto-Oncogene Proteins c-raf