title: Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.
abstract: Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer. Upper urinary tract urothelial cell carcinomas (UUT-UCC) are rare (5% of all urothelial carcinomas). We genotyped 268 patients with UUT-UCC and 268 healthy controls matched for age, gender, tobacco consumption, and ethnicity. His213 (SULT1A1*2) allele frequency was significantly higher in patients than in controls (37.1% versus 28.9%; P=0.004). The His/His genotype corresponding to low-activity SULT1A1 enzyme conferred a significantly higher risk of UUT-UCC (odds ratio, 2.18; 95% confidence interval, 1.28-3.69; P=0.004
authors.affiliation: Royal Hallamshire Hospital, Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom. morgan.roupret@psl.aphp.fr
authors.forename: Morgan
authors.initials: M
authors.lastname: Rouprêt
authors.forename: Géraldine
authors.initials: G
authors.lastname: Cancel-Tassin
authors.forename: Eva
authors.initials: E
authors.lastname: Comperat
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Fromont
authors.forename: Mathilde
authors.initials: M
authors.lastname: Sibony
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinié
authors.forename: Yves
authors.initials: Y
authors.lastname: Allory
authors.forename: Stéphane
authors.initials: S
authors.lastname: Triau
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Champigneulle
authors.forename: Cécile
authors.initials: C
authors.lastname: Gaffory
authors.forename: Stéphane
authors.initials: S
authors.lastname: Larré
authors.forename: Alexandre
authors.initials: A
authors.lastname: de la Taille
authors.forename: François
authors.initials: F
authors.lastname: Richard
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: Olivier
authors.initials: O
authors.lastname: Cussenot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015239:Arylsulfotransferase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014571:Urologic Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D019459:Urothelium / Q000473:pathology
chemical_list: D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human