title: Ninety percent of celiac disease is being missed.
abstract: Serological screening of 5470 children age 7.5 years from a cohort of 13,971 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) suggested the prevalence of celiac disease (CD) to be at least 1%. ALSPAC is an anonymous study, and hence seropositive children could not be individually identified or undergo biopsy. Inasmuch as all children within ALSPAC suspected of having CD are referred to just 1 center, we aimed to identify children with biopsy-confirmed CD who were likely to be in this cohort and to estimate the magnitude of discrepancy between serology-positive cases and biopsy-confirmed cases. The results suggest that more than 90% of CD in children goes undiagnosed.
authors.affiliation: Department of Gastroenterology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol, UK.
authors.forename: M
authors.initials: M
authors.lastname: Ravikumara
authors.forename: V K T
authors.initials: VK
authors.lastname: Nootigattu
authors.forename: B K
authors.initials: BK
authors.lastname: Sandhu
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D015995:Prevalence; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D015415:Biomarkers