title: Synthesis of C8-alkylamino substituted 2'-deoxyguanosine.
abstract: Synthesis of C8-alkynyl- and alkylamino substituted 2'-deoxyguanosine is described. Protected alkynylamines are coupled with 8-bromo-2'-deoxyguanosine by a Pd(0)-mediate Sonogashira coupling protocol. Hydrogenation of alkynyl derivatives over 10% Pd/C under atmospheric pressure gave 8-alkylamino guanosine derivatives in nearly quantitative yields.
authors.affiliation: Department of Marerials Chemistry and Engineering, School of Engineering, and NEWCAT Institute, Graduate school of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan. saito@chem.ce.nihon-u.au.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Saito
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Subhendu Sekhar
authors.initials: SS
authors.lastname: Bag
authors.forename: Shinji
authors.initials: S
authors.lastname: Ogasawara
authors.forename: Isamu
authors.initials: I
authors.lastname: Suzuka
authors.forename: Isao
authors.initials: I
authors.lastname: Saito
mesh_terms: D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015345:Oligonucleotide Probes / Q000737:chemistry
chemical_list: D015345:Oligonucleotide Probes; D003849:Deoxyguanosine