Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice.
The antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia were investigated in the forced swimming test (FST) in ICR strain of male mice. Psoralidin significantly decreased immobility time and increased swimming behavior without altering climbing behavior in the mouse FST after oral administration for 1 h or 3 consecutive days. Psoralidin did not affect locomotor activity in the open-field test. After a 3-day treatment, psoralidin significantly increased 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in various brain regions, as well as, changed dopamine (DA) levels in striatum in mice exposed to FST. Psoralidin also ameliorated the elevations in serum corticotropin-releasing factor (CRF), adrenal corticotropin-releasing hormone (ACTH) and corticosterone concentrations induced by swimming stress in mice. These results suggested that psoralidin possessed potent antidepressant-like properties that were mediated via the monoamine neurotransmitter and the hypothalamic-pituitary-adrenal (HPA) axis systems.
Yi
Li-Tao
LT
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China.
Li
Yu-Cheng
YC
Pan
Ying
Y
Li
Jian-Mei
JM
Xu
Qun
Q
Mo
Shi-Fu
SF
Qiao
Chun-Feng
CF
Jiang
Fu-Xin
FX
Xu
Hong-Xi
HX
Lu
Xiao-Bo
XB
Kong
Ling-Dong
LD
Kung
Hsiang-Fu
HF
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D046353:Immobility Response, Tonic / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D029907:Psoralea / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012701:Serotonin / Q000032:analysis; D013550:Swimming / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014018:Tissue Distribution / Q000187:drug effects
D000928:Antidepressive Agents; D001572:Benzofurans; D003374:Coumarins; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; C102768:psoralidin; D003345:Corticosterone