Cell-autonomous immunity to Toxoplasma gondii in mouse and man.
The protozoan, Toxoplasma gondii, is a natural pathogen of mouse and a zoonosis of man. Immunity against the pathogen is largely mediated by interferon-stimulated cell-autonomous mechanisms that are strikingly different between man and mouse. There are many poorly understood host and pathogen variables that affect the outcome of infection.
Könen-Waisman
Stephanie
S
Institute for Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany.
Howard
Jonathan C
JC
D000818:Animals; D005347:Fibroblasts / Q000276:immunology / Q000469:parasitology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D008264:Macrophages / Q000276:immunology / Q000469:parasitology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014122:Toxoplasma / Q000472:pathogenicity* / Q000502:physiology; D014123:Toxoplasmosis / Q000276:immunology* / Q000469:parasitology; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000469:parasitology
D007372:Interferons