title: [The effects of extremely low-frequency electromagnetic fields on rat osteoblast].
abstract: The performance of extremely low-frequency electromagnetic fields (ELEF) can change the response of osteoblasts. In this study a kind of ELEF stimulator, which can radiate sinusoidal, rectangular, triangular and pulsed burst ELEF with frequency of 0-300 Hz and strength of 0-40 mT was developed. The neonatal rat calvarial osteoblasts were treated with the device. The effects of various ELEF stimulation on the osteoblast were evaluated by its proliferation and differentiation. The results demonstrated that rectangular and pulsed burst radiation (15Hz, 5mT) can positively change the proliferation of the osteoblast and inhibit its differentiation, but the sinusoidal one can significantly enhance its differentiation and decrease its proliferation.
authors.affiliation: Key Laboratory of Biomedical Information of Ministry of Education and Institute of Biomedical Engineering, Xian Jiaotong University, Xian 710049, China.
authors.forename: Jianbao
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Wen
authors.forename: Xuemin
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000528:radiation effects*; D049109:Cell Proliferation / Q000528:radiation effects*; D002478:Cells, Cultured; D004574:Electromagnetic Fields; D010006:Osteoblasts / Q000166:cytology* / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000166:cytology