Angiogenesis and obesity.
Development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis, and extracellular matrix remodelling. These processes require proteolytic activity, provided mainly by the fibrinolytic (plasminogen/plasmin), matrix metalloproteinase, and ADAM/ADAMTS systems. In early-stage development of adipose tissue, adipogenesis is tightly associated with angiogenesis. Thus, adipose tissue explants trigger blood vessel formation, and in turn adipose tissue endothelial cells promote pre-adipocyte differentiation. Modulation of angiogenesis and of proteolytic systems may have the potential to impair adipose tissue development.
Lijnen
H Roger
HR
Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium. roger.lijnen@med.kuleuven.be
D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D015398:Signal Transduction
D054392:Adipokines; D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D019440:Anti-Obesity Agents; D011480:Protease Inhibitors; D010447:Peptide Hydrolases