Drugs acting on SUR1 to treat CNS ischemia and trauma.
Sulfonylurea receptor 1 (SUR1) is a molecule with more diverse and critically important functions than previously recognized. Long viewed simply as a subunit involved in formation of a subset of K(ATP) channels, accumulating evidence indicates that SUR1 is newly upregulated in CNS ischemia and injury and is surprisingly promiscuous in its association with different pore-forming subunits, which endow it with new roles not previously envisioned. In this review, we focus on the SUR1-regulated NC(Ca-ATP) channel, its emerging role in CNS ischemia and trauma, and the growing evidence from preclinical and clinical studies demonstrating the potential importance of block of SUR1 by sulfonylureas such as glibenclamide (glyburide) in conditions as seemingly diverse as stroke and spinal cord injury.
Simard
J Marc
JM
Department of Neurosurgery, University of Maryland School of Medicine, 22 S. Greene St., Suite 12SD, Baltimore, MD 21201-1595, USA. msimard@smail.umaryland.edu
Woo
S Kyoon
SK
Bhatta
Sergei
S
Gerzanich
Volodymyr
V
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000502:physiology; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D006801:Humans; D054086:KATP Channels / Q000502:physiology; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D015221:Potassium Channels / Q000502:physiology; D024661:Potassium Channels, Inwardly Rectifying / Q000037:antagonists & inhibitors* / Q000502:physiology; D011955:Receptors, Drug / Q000037:antagonists & inhibitors* / Q000502:physiology; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D020521:Stroke / Q000188:drug therapy*; D064233:Sulfonylurea Receptors
C577507:ABCC8 protein, human; D018528:ATP-Binding Cassette Transporters; D054086:KATP Channels; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors