Biodegradable and biomimetic poly(epsilon-caprolactone)/poly(lactobionamidoethyl methacrylate) biohybrids: synthesis, lactose-installed nanoparticles and recognition properties.
Biodegradable and biomimetic SPCL-PLAMA biohybrids were synthesized via ATRP and characterized by FT-IR, (1)H NMR, GPC and DSC. Biohybrids with small PDI were obtained, and the block length of the PLAMA glycopolymer could be varied linearly by the varying the molar ratio of glycomonomer to macroinitiator. The outer PLAMA glycopolymer restrained the crystallization of inner PCL segments. The self-assembly properties of amphiphilic biohybrids were studied. Lactose-installed aggregates were fabricated in aqueous solution; they changed from spherical micelles to vesicles with increasing weight fraction of hydrophobic PCL. The SPCL-PLAMA biohybrids showed specific recognition for RCA(120) lectin.
Zhou
Wei
W
Department of Polymer Science and Engineering, School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China.
Dai
Xiao-Hui
XH
Dong
Chang-Ming
CM
D040761:Biomimetic Materials / Q000737:chemistry*; D002850:Chromatography, Gel; D004187:Disaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D004187:Disaccharides; D008689:Methacrylates; D011091:Polyesters; C522311:lactobionamide; C016240:polycaprolactone