title: UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
abstract: BACKGROUND
  We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC).
  
  
  METHODS
  The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were men younger than 75 years. HCC and cirrhosis patients were stratified according to time since cirrhosis diagnosis.
  
  
  RESULTS
  We found a positive association between the UGT1A7*3/*3 genotype and HCC when the comparison was restricted to patients whose disease was of viral origin [OR = 3.4 (0.3-45)] but a negative association when it included only alcoholic patients [OR = 0.1 (0.02-0.6), p = 0.01].
  
  
  CONCLUSIONS
  Our study shows that UGT1A7 may play a role in hepatocellular carcinogenesis and that this role may differ according to the primary cause of the cirrhosis.
authors.affiliation: Inserm, U754, Villejuif, F-94807 France. stucker@vjf.inserm.fr
authors.forename: I
authors.initials: I
authors.lastname: Stücker
authors.forename: M A
authors.initials: MA
authors.lastname: Loriot
authors.forename: G
authors.initials: G
authors.lastname: N'koutchou
authors.forename: S
authors.initials: S
authors.lastname: Cénée
authors.forename: L
authors.initials: L
authors.lastname: Bodin
authors.forename: C
authors.initials: C
authors.lastname: Mulot
authors.forename: M
authors.initials: M
authors.lastname: Gelu-Simeon
authors.forename: L
authors.initials: L
authors.lastname: Pelletier
authors.forename: J P
authors.initials: JP
authors.lastname: Bronowicki
authors.forename: F
authors.initials: F
authors.lastname: Degos
authors.forename: P
authors.initials: P
authors.lastname: Beaune
authors.forename: P
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: D
authors.initials: D
authors.lastname: Hémon
authors.forename: J C
authors.initials: JC
authors.lastname: Trinchet
authors.forename: G
authors.initials: G
authors.lastname: Pelletier
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D014453:Glucuronosyltransferase / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications / Q000201:enzymology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006526:Hepatitis C / Q000150:complications / Q000201:enzymology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000201:enzymology; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012698:Serologic Tests
chemical_list: D015415:Biomarkers; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D014453:Glucuronosyltransferase