Thermodynamics of dimerization of parallel quadruplex DNAs through the end-to-end stacking of 3'-terminal G-quartets.
DNA sequence d(TTAGGG) spontaneously forms all-parallel G-quadruplex DNA in the presence of KV We have shown that G-quadruplex DNAs formed from the related sequences undergo dimerization through the intermolecular end-to-end stacking of the 3'-terminal G-quartets. 2' 3 We found that the coexistence of G-quadruplex DNAs formed from two different sequences results in the formation of "hetero-dimer", in addition to "homo-dimer". Thermodynamic characterization of the dimerization process revealed a compensatory relationship between the enthalpy and entropy changes of the process.
Sakuma
Noriko
N
Department of Chemistry, University of Tsukuba.Tsukuba 305-8571, Japan.
Ozawa
Makie
M
Kawano
Shin
S
Mita
Hajime
H
Hemmi
Hikaru
H
Yamamoto
Yasuhiko
Y
D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; D004247:DNA