title: Peripheral atherosclerosis is associated with the occurrence of restenosis after percutaneous coronary intervention.
abstract: BACKGROUND
  The aim of our study was to evaluate, in patients with proven coronary artery disease (CAD) and treated with elective percutaneous coronary intervention (PCI), whether the coexistence of asymptomatic carotid and femoral atherosclerotic lesions would provide prognostic information in terms of occurrence of restenosis.
  
  
  METHODS
  We studied 104 patients with CAD (M/F=77/27), mean age 60.5+/-9 years. All patients were treated with elective PCI. After PCI the suspicion of restenosis was confirmed by coronary angiography. All patients underwent ultrasound duplex scan of carotid and femoral-popliteal-tibial axis to detect atherosclerotic lesions. According to ultrasound results, patients were classified as normal, with increased intima-media thickness (IMT) or with asymptomatic plaque (AP). If carotid and femoral lesions coexisted (together with coronary ones) patients were considered to have multifocal atherosclerosis.
  
  
  RESULTS
  About 90% of the patients had carotid lesions: 40% had carotid IMT and 50% AP. Femoral lesions were found in 72% of the population and in 41% there was an increased IMT and in 21% an increased AP. Prevalence of restenosis after PCI was 12.5%. Patients with restenosis had a significantly higher prevalence of asymptomatic carotid and/or femoral lesions than those without restenosis. The occurrence of restenosis was independently associated with the detection of carotid, femoral and multifocal atherosclerosis.
  
  
  CONCLUSIONS
  The detection of carotid and/or peripheral atherosclerotic lesions in patients with CAD who underwent PCI may be a marker of increased risk. We believe that investigating these areas, by echo-Doppler duplex scanning, may be a cost-effective strategy in the work-up before elective PCI. It may allow identification of high-risk subgroups of patients, and enable the planning of patient-tailored therapeutic strategies and follow-up.
authors.affiliation: Department of Internal Medicine and Cardiovascular Disease, Division of Cardiology, University of Palermo, Italy. pepenovo@hotmail.com
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Novo
authors.forename: Deborha
authors.initials: D
authors.lastname: Maniglia
authors.forename: Maniglia
authors.initials: M
authors.lastname: Deborha
authors.forename: Egle
authors.initials: E
authors.lastname: Corrado
authors.forename: Corrado
authors.initials: C
authors.lastname: Egle
authors.forename: Ida
authors.initials: I
authors.lastname: Muratori
authors.forename: Muratori
authors.initials: M
authors.lastname: Ida
authors.forename: Fiorella
authors.initials: F
authors.lastname: Sutera
authors.forename: Sutera
authors.initials: S
authors.lastname: Fiorella
authors.forename: Salvatore
authors.initials: S
authors.lastname: Evola
authors.forename: Evola
authors.initials: E
authors.lastname: Salvatore
authors.forename: Filippo
authors.initials: F
authors.lastname: Ferrara
authors.forename: Ferrara
authors.initials: F
authors.lastname: Filippo
authors.forename: Enrico
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Hoffmann
authors.initials: H
authors.lastname: Enrico
authors.forename: Salvatore
authors.initials: S
authors.lastname: Novo
authors.forename: Novo
authors.initials: N
authors.lastname: Salvatore
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D050197:Atherosclerosis / Q000150:complications*; D023903:Coronary Restenosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications*; D011379:Prognosis