A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives.
Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
Wang
Fei
F
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. wfei77502@sina.com
Wang
Jiawei
J
Zhang
Shoufang
S
D000818:Animals; D003500:Cyclization / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000628:therapy; D008297:Male; D051379:Mice; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011719:Pyrazines; D011758:Pyrroles