Local control and distant metastasis after electrochemotherapy of a canine anal melanoma.
Canine anal melanoma is an aggressive neoplasm that rapidly leads to constipation in dogs, thus mimicking the behavior of their human counterpart. In this paper, the successful local palliation of this neoplasm is described using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction with restoration of normal defecation for three months, then experienced massive dissemination to the sublumbar lymph nodes that led to intestinal obstruction and euthanasia. Electrochemotherapy (ECT) is a safe palliative therapy for such neoplasm and warrants further investigations in dogs as well humans.
Spugnini
Enrico P
EP
Centre of Biomedical Engineering Ivan Daskalov, Sofia, Bulgaria. info@enricospugnini.net
Filipponi
Marino
M
Romani
Luca
L
Dotsinsky
Ivan
I
Mudrov
Nikolay
N
Baroni
Adone
A
Ruocco
Eleonora
E
Laieta
Maria Teresa
MT
Montesarchio
Vincenzo
V
Cassandro
Roberto
R
Citro
Gennaro
G
Baldi
Alfonso
A
D000818:Animals; D001005:Anus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D053672:Electrochemotherapy; D005260:Female; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology