title: Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder.
abstract: OBJECTIVE
  The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely loaded family history.
  
  
  METHODS
  The sample (average age of 17.5, SD 4.5) consisted of 54 high-risk offspring (HR) having one parent affected by a DSM-IV SZ or BP. The parents descended from 21 multigenerational families that constitute a quasi-total sample of such kindred in eastern Québec. The HRs were administered a lifetime best estimate DSM-IV diagnosis.
  
  
  RESULTS
  We observed that the rates, the diversity of diagnoses, the high comorbidity, the severity and the age of onset of the clinical diagnoses tended to be similar with those already reported in the offspring of affected parents with a low familial loading. Although the sample size was small, HRSZ and HRBP also tended to show similarities in their clinical status.
  
  
  CONCLUSIONS
  Overall, taking into account methodological limitations, the observation early in life of some shared characteristics among HRSZ and HRBP in terms of non-psychotic diagnosis may be congruent with the accumulating evidence that several phenotypic features are shared in adulthood by the two major psychoses.
authors.affiliation: Centre de recherche Université Laval Robert-Giffard, QC, Canada. michel.maziade@psa.ulaval.ca
authors.forename: M
authors.initials: M
authors.lastname: Maziade
authors.forename: N
authors.initials: N
authors.lastname: Gingras
authors.forename: N
authors.initials: N
authors.lastname: Rouleau
authors.forename: S
authors.initials: S
authors.lastname: Poulin
authors.forename: V
authors.initials: V
authors.lastname: Jomphe
authors.forename: M-E
authors.initials: ME
authors.lastname: Paradis
authors.forename: C
authors.initials: C
authors.lastname: Mérette
authors.forename: M-A
authors.initials: MA
authors.lastname: Roy
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics*; D002170:Canada / Q000453:epidemiology; D002391:Catchment Area, Health; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010375:Pedigree; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*