Antigen presentation the macrophage way.
Multiphoton intravital microscopy of lymph nodes has revolutionized the study of the early events leading to induction of acquired immunity. Using this technique, Junt et al. (2007) report in a recent issue of Nature that macrophages of the mouse lymph node subcapsular sinus facilitate B cell activation in vivo by collecting and displaying native antigen.
Martinez-Pomares
Luisa
L
Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen's Medical Centre, Floor A, West Block, room 1323, Nottingham, NG7 2UH, UK. luisa.martinez-pomares@nottingham.ac.uk
Gordon
Siamon
S
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure; D051379:Mice
D000941:Antigens