title: Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma.
abstract: Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.
authors.affiliation: Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan. keisuke1@po.mdu.ac.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakano
authors.forename: Takehiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Takako
authors.initials: T
authors.lastname: Shimizu
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawakami
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010006:Osteoblasts / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*