Synthesis of the key precursor of Hirsutellide A.
Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
Xu
Yanjie
Y
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, PR China.
Duan
Xuemin
X
Li
Meiling
M
Jiang
Liqin
L
Zhao
Guangle
G
Meng
Yi
Y
Chen
Ligong
L
D008954:Models, Biological; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis; D011498:Protein Precursors / Q000138:chemical synthesis*
D010456:Peptides, Cyclic; D011355:Prodrugs; D011498:Protein Precursors; C470802:hirsutellide A