title: Regulation of bacterial protease activity.
abstract: Proteases, also referred to as peptidases, are the enzymes that catalyse the hydrolysis of peptide bonds in polipeptides. A variety of biological functions and processes depend on their activity. Regardless of the organism's complexity, peptidases are essential at every stage of life of every individual cell, since all protein molecules produced must be proteolytically processed and eventually recycled. Protease inhibitors play a crucial role in the required strict and multilevel control of the activity of proteases involved in processes conditioning both the physiological and pathophysiological functioning of an organism, as well as in host-pathogen interactions. This review describes the regulation of activity of bacterial proteases produced by dangerous human pathogens, focusing on the Staphylococcus genus.
authors.affiliation: Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. wladykab@interia.pl
authors.forename: Benedykt
authors.initials: B
authors.lastname: Władyka
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pustelny
mesh_terms: D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases