title: Impact of polymorphism in IL-1RA gene on the risk of cervical cancer.
abstract: BACKGROUND
  Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). However, although many women are infected with high-risk types of HPV, only a subset of infected women will ever develop cervical cancer. Therefore, host genetic factor may play a role in cervical carcinogenesis. Several studies suggested that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1RA gene was associated with various malignant diseases. Data are lacking for cervical cancer.
  
  
  METHODS
  In a case-control study we analyzed the polymorphism of IL-1RA in 150 women with cervical cancer and 209 healthy controls. Genomic DNA fragments were amplified by PCR.
  
  
  RESULTS
  There was a strong significantly protective association between heterozygous AB genotype and HPV 18 (OR = 0.11, 95% CI = 0.04-0.30, p = 0.0000000). Similarly this result was demonstrated, in combined AB + BB genotypes of IL-1RA with HPV 18 (OR = 0.12, 95% CI= 0.05-0.30, p = 0.0000000) and HPV type 16 + 18 (OR = 0.18,95% CI = 0.08-0.38, p = 0.000005). We found high protective significant association between heterozygous genotype AB with adenocarcinoma (OR = 0.19, 95% CI = 0.09-0.40, p = 0.0000002) as well.
  
  
  CONCLUSIONS
  These findings therefore suggest that the IL1-RA polymorphism is associated with cervical cancer.
authors.affiliation: Department of Biotechnology, Panjab University, Chandigarh, India. dor_kordi@yahoo.com
authors.forename: Dor Mohammad Kordi
authors.initials: DM
authors.lastname: Tamandani
authors.forename: Ranbir Chander
authors.initials: RC
authors.lastname: Sobti
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shekari
authors.forename: Satinder
authors.initials: S
authors.lastname: Kaur
authors.forename: Anju
authors.initials: A
authors.lastname: Huria
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000821:virology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D052162:Human papillomavirus 16; D052161:Human papillomavirus 18; D006801:Humans; D007194:India; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein