Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua.
Two new phenylpropanoid-substituted epicatechins, namely, catiguanin A ( 1) and catiguanin B ( 2), were isolated from the bark of Trichilia catigua along with four known compounds, cinchonain Ia ( 3), cinchonain Ib ( 4), cinchonain Ic ( 5), and cinchonain Id ( 6). The structures of 1 and 2 were elucidated by analysis of spectroscopic data and by comparison of their NMR data with those of previously reported cinchonains. The isolated compounds exhibited potent antioxidant activity in the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging test, with IC 50 values in the 2.3-9.4 microM range.
Tang
Wanxia
W
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Hioki
Hideaki
H
Harada
Kenichi
K
Kubo
Miwa
M
Fukuyama
Yoshiyasu
Y
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D001938:Brazil; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010666:Phenylpropionates; D010851:Picrates; C527018:catiguanin A; C527019:catiguanin B; D002392:Catechin; C004931:1,1-diphenyl-2-picrylhydrazyl