title: The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.
abstract: A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.
authors.affiliation: Institut Curie, Section Recherche, CNRS UMR176, Centre Universitaire Paris XI, Bât. 110, 91405 Orsay, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Bertrand
authors.forename: David
authors.initials: D
authors.lastname: Monchaud
authors.forename: Anne
authors.initials: A
authors.lastname: De Cian
authors.forename: Régis
authors.initials: R
authors.lastname: Guillot
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Teulade-Fichou
mesh_terms: D001667:Binding, Competitive; D018360:Crystallography, X-Ray; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D011725:Pyridines