MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer.
This paper presents the Generalized CaseView method applied to the study of polymorphisms of MDR1 (Multi Drug Resistant), a gene coding for a trans-membrane transporting protein. The data base contains Single nucleotide polymorphisms, their positions in cDNA, and the Area Under the Curve of drugs concentrations. The generalized CaseView method permits a compact visualization of these data. The main result is that pharmacokinetics of some anticancer drugs depends on the genotype.
Xhemo
Edlira
E
Public Health Department, Tenon Hospital, 75020 Paris, France. e.xhemo@yahoo.com
Fajac
Anne
A
Boire
Jean-Yves
JY
Levy
Pierre
P
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics*; D000077143:Docetaxel; D004317:Doxorubicin / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012984:Software; D043823:Taxoids / Q000493:pharmacokinetics / Q000627:therapeutic use
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin