Gabapentin: a multimodal perioperative drug?
Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic response to laryngoscopy and intubation, and preventing chronic post-surgical pain, postoperative nausea and vomiting, and delirium. This article reviews the clinical trial data describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management.
Kong
V K F
VK
Department of Anaesthesiology, Queen Mary Hospital, The University of Hong Kong, HKSAR, Hong Kong.
Irwin
M G
MG
D000588:Amines / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D003693:Delirium / Q000517:prevention & control; D000077206:Gabapentin; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control; D011292:Premedication / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000588:Amines; D018712:Analgesics, Non-Narcotic; D014151:Anti-Anxiety Agents; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin