The regulatory T cell transcriptosome: E pluribus unum.
The regulatory T (Treg) cell transcriptional program is formed of distinct genetic networks that respond to different activators. In this issue of Immunity, Hill et al. (2007) provide insights into the interactions among the different networks and the overall role of Foxp3 in shaping the Treg cell transcriptosome.
Chatila
Talal
T
Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095, USA. tchatila@mednet.ucla.edu
D000818:Animals; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology*; D020869:Gene Expression Profiling; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors