title: Current therapies in childhood and adolescent migraine.
abstract: This review summarizes recent guidelines for diagnosis of migraine in children and adolescents and inherent issues regarding their headaches that influence evaluation of therapies. With the shorter duration of pediatric migraine attacks and the prominent placebo responder rate, design of randomized clinical trials becomes more problematic than in the adult population. Regarding abortive therapies, several agents have appreciable efficacy in randomized controlled trials. Ibuprofen, acetaminophen, and sumatriptan nasal spray are probably beneficial and safe to use in pediatric migraine. For the minority of children who should be candidates for prophylactic therapy, there is a limited amount of information available for clinicians to make judicious treatment decisions.
authors.affiliation: Department of Pediatrics and Neurology, Ohio State University College of Medicine and Columbus Children's Hospital, Columbus, Ohio, USA. PakalnisA@pediatrics.ohio-state.edu
authors.forename: Ann
authors.initials: A
authors.lastname: Pakalnis
mesh_terms: D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008881:Migraine Disorders / Q000628:therapy*; D010372:Pediatrics
chemical_list: D000700:Analgesics