title: A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice.
abstract: Automated detection of amyloid plaques (AP) in post mortem brain sections of patients with Alzheimer disease (AD) or in mouse models of the disease is a major issue to improve quantitative, standardized and accurate assessment of neuropathological lesions as well as of their modulation by treatment. We propose a new segmentation method to automatically detect amyloid plaques in Congo Red stained sections based on adaptive thresholds and a dedicated amyloid plaque/tissue modelling. A set of histological sections focusing on anatomical structures was used to validate the method in comparison to expert segmentation.
authors.affiliation: Medical Image Research Center, URA CEA-CNRS 2210, 4 place du Général Leclerc, 914006 Orsay Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Teboul
authors.forename: Abdelmonem
authors.initials: A
authors.lastname: Feki
authors.forename: Albertine
authors.initials: A
authors.lastname: Dubois
authors.forename: Bruno
authors.initials: B
authors.lastname: Bozon
authors.forename: Alexis
authors.initials: A
authors.lastname: Faure
authors.forename: Philippe
authors.initials: P
authors.lastname: Hantraye
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
authors.forename: Benoit
authors.initials: B
authors.lastname: Delatour
authors.forename: Thierry
authors.initials: T
authors.lastname: Delzescaux
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D001185:Artificial Intelligence; D001921:Brain / Q000473:pathology*; D003124:Colorimetry / Q000379:methods*; D003224:Congo Red; D003287:Contrast Media; D004195:Disease Models, Animal; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D051379:Mice; D008822:Mice, Transgenic; D010363:Pattern Recognition, Automated / Q000379:methods; D058225:Plaque, Amyloid / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D003224:Congo Red