title: Clickable 2'-O-alkyladenosine building blocks.
abstract: An efficient and selective synthesis of 2'-O-alkyl modified adenosine nucleosides carrying either a triple bond function or an azido group is reported. These nucleosides are thus armed for performing 1,3 dipolar cycloadditions (click chemistry)(1). Derivatives suitable for further conversion into different building blocks are reported.
authors.affiliation: Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wenska
authors.forename: Stefan
authors.initials: S
authors.lastname: Milton
authors.forename: Roger
authors.initials: R
authors.lastname: Strömberg
mesh_terms: D000227:Adenine Nucleotides / Q000737:chemistry; D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000227:Adenine Nucleotides; D009841:Oligonucleotides; D000241:Adenosine