Effect of Tokaj wine in combination with water and 10% alcohol solution on long-life and development of alcohol progeria in Wistar SPF rats.
Whole-life consumption of the pure Tokaj wine (The Furmint variety) with documented antioxidative activity significantly elongated (p<0.05) the life of laboratory animals in comparison to the control group consuming water and in comparison to group consuming ethanol (10%). Whole-life intake of ethanol (10%) diluted with water neither shortened nor elongated life of laboratory animals in comparison to control group consuming water. An increased dosing of the Tokaj wine combined with water shortened life expectation (p<0.001). Obviously mixing of wine and water increases the absorption of toxic elements influenced by an acid medium through the change of anions to cations, but also increased appetite resulting into obesity on the basis of hyperphagia.
Molnar
A
A
University of Paul Joseph Safarik, Faculty of Medicine, Department Pharmacology, Kosice, Slovakia.
Nicak
A
A
Skvarla
J
J
Navesnakova
Y
Y
Skvarlova
A
A
Beno
P
P
Krcmery
V
V
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D008136:Longevity / Q000187:drug effects; D008297:Male; D011371:Progeria / Q000139:chemically induced* / Q000453:epidemiology; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D013482:Superoxide Dismutase / Q000378:metabolism; D014867:Water; D014920:Wine / Q000032:analysis
D000975:Antioxidants; D014867:Water; D000431:Ethanol; D002374:Catalase; D013482:Superoxide Dismutase