Covalent polymer-drug conjugates.
In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and polymer-proteins conjugates recently developed.
Elvira
Carlos
C
Institute of Polymer Science and Technology (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. ictep13@ictp.csic.es
Gallardo
Alberto
A
Roman
Julio San
JS
Cifuentes
Alejandro
A
D016503:Drug Delivery Systems; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
D004364:Pharmaceutical Preparations; D011108:Polymers