Lower dopamine transporter density in an asymptomatic patient with Kleine-Levin syndrome.
BACKGROUND
Kleine-Levin syndrome (KLS) is a rare disorder whose pathophysiological mechanisms remain unknown.


METHODS
To investigate dopamine abnormalities in KLS, a [99mTc]-TRODAT-1 single photon emission computerized tomography (SPECT) was performed in a patient with KLS during the asymptomatic period and compared with three matched healthy controls.


RESULTS
The patient had 14% lower striatal dopamine transporter binding potential (DAT-BP) compared to the mean DAT-BP of three healthy controls.


CONCLUSIONS
This study provides in vivo evidence for abnormalities in the DAT-BP, suggesting an involvement of the dopaminergic system in the pathophysiology of KLS.
Hoexter
M Q
MQ
LiNC-Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil. mqhoexter@psiquiatria.epm.br
Shih
M C
MC
Mendes
D D
DD
Godeiro-Junior
C
C
Felicio
A C
AC
Fu
Y K
YK
Tufik
S
S
Bressan
R A
RA
D000293:Adolescent; D016022:Case-Control Studies; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D015609:Organotechnetium Compounds; D017286:Polysomnography / Q000379:methods; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes
D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1