title: Aromatase inhibitor-associated arthralgia and/ or bone pain: frequency and characterization in non-clinical trial patients.
abstract: BACKGROUND
  The frequency of aromatase inhibitor (AI)-associated arthralgia and/or bone pain in clinical practice is not known.
  
  
  METHODS
  Fifty-six consecutive patients with breast cancer not on clinical trials who were receiving AIs in a clinical practice were interviewed regarding occurrence of worsening or new arthralgia and/or bone pain after starting AI therapy. The occurrence, character, severity, and resolution of pain were evaluated.
  
  
  RESULTS
  Arthralgia and/or bone pain was reported in 61% of patients. It was severe in 30%, continuous in 41%, central in 50%, peripheral in 79%, and resulted in discontinuation of the drug in 20% of patients. Effective therapies in controlling pain were acetaminophen, 29%; nonsteroidal anti-inflammatory drugs, 50%; opiates, 18%, and glucosamine in 15% of patients. Despite this, 20% of patients discontinued AI therapy because of pain.
  
  
  CONCLUSIONS
  Aromatase inhibitor-associated pain is more frequent in patients not in clinical trials than previously appreciated in clinical trials. Improved patient education is needed, and prompt therapeutic management of pain is required to ensure continued drug treatment and improved quality of life.
authors.affiliation: Wilshire Oncology Medical Group, West Covina, CA 91790, USA. cary.presant@womgi.com
authors.forename: Cary A
authors.initials: CA
authors.lastname: Presant
authors.forename: Linda
authors.initials: L
authors.lastname: Bosserman
authors.forename: Traci
authors.initials: T
authors.lastname: Young
authors.forename: Mayank
authors.initials: M
authors.lastname: Vakil
authors.forename: Richard
authors.initials: R
authors.lastname: Horns
authors.forename: Gargi
authors.initials: G
authors.lastname: Upadhyaya
authors.forename: Behnam
authors.initials: B
authors.lastname: Ebrahimi
authors.forename: Christina
authors.initials: C
authors.lastname: Yeon
authors.forename: Frank
authors.initials: F
authors.lastname: Howard
mesh_terms: D047072:Aromatase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D018771:Arthralgia / Q000139:chemically induced* / Q000453:epidemiology*; D001842:Bone and Bones / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D010146:Pain / Q000139:chemically induced* / Q000453:epidemiology*
chemical_list: D047072:Aromatase Inhibitors