title: Albright's hereditary osteodystrophy with extensive heterotopic ossification of the oral and maxillofacial region: how fetuin research may help a seemingly impossible condition.
abstract: Albright"s hereditary osteodystrophy (AHO) is a complex genetic disorder characterized by brachydactyly, gonadotropin resistance, hypothyroidism, pseudohypoparathyroid syndrome and heterotopic ossification. Heterotopic ossification rarely occurs in the maxillofacial region. In this article, we present such a case, describe the etiology, characteristics and treatment of AHO and suggest a potential role of an inhibitor of bone formation such as fetuin in preventing recurrence of aberrant ossification.
authors.affiliation: Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Marc G
authors.initials: MG
authors.lastname: DuVal
authors.forename: Sarah
authors.initials: S
authors.lastname: Davidson
authors.forename: Andrew
authors.initials: A
authors.lastname: Ho
authors.forename: Rachale
authors.initials: R
authors.lastname: Cohen
authors.forename: Michael
authors.initials: M
authors.lastname: Park
authors.forename: Somayeh
authors.initials: S
authors.lastname: Nourian
authors.forename: Gerald
authors.initials: G
authors.lastname: Baker
authors.forename: George K B
authors.initials: GK
authors.lastname: Sándor
mesh_terms: D000293:Adolescent; D000844:Ankylosis / Q000209:etiology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications*; D006801:Humans; D008297:Male; D008410:Masticatory Muscles / Q000503:physiopathology; D019767:Maxillofacial Abnormalities / Q000209:etiology*; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000517:prevention & control; D010012:Osteogenesis / Q000502:physiology; D011556:Pseudopseudohypoparathyroidism / Q000150:complications*; D013705:Temporomandibular Joint Disorders / Q000209:etiology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; D053773:Transforming Growth Factor beta1; D000509:alpha-Fetoproteins