title: Biosensing based on two-photon fluorescence measurements through optical fibers.
abstract: We have performed two-photon fluorescence detection in a new scheme in which femtosecond laser pulses were delivered thorugh an optical fiber for nonlinear excitation and the emitted fluorescence was collected through the same fiber. Single-mode fibers were determined to give higher detection efficiency than multimode fibers, consistent with theoretical considerations. The utility of fiber-optic sensing based on two-photon fluorescence detection was proved by an experiment that measured the uptake of a targeted drug delivery agent into cultured cancer cells.
authors.forename: Jing Yong
authors.initials: JY
authors.lastname: Ye
authors.forename: Mon Thiri
authors.initials: MT
authors.lastname: Myaing
authors.forename: Theodore B
authors.initials: TB
authors.lastname: Norris
authors.forename: Thommey
authors.initials: T
authors.lastname: Thomas
authors.forename: James
authors.initials: J
authors.lastname: Baker