title: Towards a synthesis of vigabatrin using glycal chemistry.
abstract: Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Madras, India.
authors.forename: Sobhana B
authors.initials: SB
authors.lastname: Boga
authors.forename: Jaimala S
authors.initials: JS
authors.lastname: Aidhen
authors.forename: Indrapal S
authors.initials: IS
authors.lastname: Aidhen
mesh_terms: D002384:Catalysis; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D020888:Vigabatrin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D020888:Vigabatrin