title: Folding pathways of human telomeric hybrid G-quadruplex structure.
abstract: The human telomeric DNA sequence d[AGGG(TTAGGG)(3)] forms the G-quadruplex structure. The G-quadruplex structure has become an attractive target for the anticancer drugs, because it effectively inhibits telomerase activity. Recently, the human telomere G-quadruplex in K(+) solution has been determined as a hybrid of mixed parallel and antiparallel structures. In this study, we investigated the folding pathway of human telomeric hybrid G-quadruplex structure.
authors.affiliation: Department of Chemistry, Graduate Schoool of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mashimo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D016615:Telomere / Q000737:chemistry*
chemical_list: D004247:DNA