title: Analysis of anatomical factors controlling the morbidity of radiation-induced otitis media with effusion.
abstract: OBJECTIVE
  To analyze the anatomical factors controlling the morbidity of radiation-induced otitis media with effusion (OME) and determine how to best preserve middle ear function when treating nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Forty patients with nasopharyngeal carcinoma undergoing 3-D radiotherapy (RT) planning and curative RT were analyzed retrospectively. The difference in dosage over the middle ear cavity and the isthmus of the Eustachian tube (ET) was evaluated. Pure tone audiometry and impedance audiometry tests were performed before and after RT.
  
  
  RESULTS
  Mean dosages over the isthmus of the ET for acoustic impedance and pure tone audiometry were recorded. Differences in dosage among the three classifications of unchanged, improved, and worsened ears were statistically significant.
  
  
  CONCLUSIONS
  There was a correlation between the morbidity of radiation-induced OME and the radiation dosage over the middle ear cavities. Decreased OME morbidity was observed when the dosage over the isthmus of the ET was below 52 Gy and the dosage over middle ear cavity was below 46 Gy.
authors.affiliation: Department of Radiotherapy and Oncology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, PR China. shengziwang@yahoo.com
authors.forename: Sheng-zi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Wei-fang
authors.initials: WF
authors.lastname: Wang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hoffman
authors.forename: Jack J
authors.initials: JJ
authors.lastname: Jiang
mesh_terms: D000158:Acoustic Impedance Tests; D001301:Audiometry, Pure-Tone; D004432:Ear, Middle / Q000033:anatomy & histology* / Q000528:radiation effects; D005064:Eustachian Tube / Q000033:anatomy & histology* / Q000528:radiation effects; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D010034:Otitis Media with Effusion / Q000209:etiology*; D012189:Retrospective Studies