[Echinomycin production by Actinomadura sp. INA 654].
An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II. Investigation of their physico-chemical properties showed that A-654-I was identical to echinomycin, a heteropeptide lactone of the quinoxaline group with antitumor activity, while A-654-II proved to be likely a new natural compound. Production of echinomycin by a representative of the Actinomadura genus was detected for the first time. Up to now, only representatives of the Streptomyces genus were known to produce echinomycin.
Galatenko
O A
OA
Terekhova
L P
LP
Li
Iu V
IuV
Malkina
N D
ND
Boĭkova
Iu V
IuV
Zenkova
V A
VA
Katrukha
G S
GS
D039903:Actinobacteria / Q000302:isolation & purification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004448:Echinomycin / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012426:Russia; D012988:Soil Microbiology
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004448:Echinomycin