Urea- hydrogen peroxide (UHP) oxidation of thiols to the corresponding disulfides promoted by maleic anhydride as mediator.
Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 oC. The products were isolated by simple filtration on silica gel.
Karami
Bahador
B
Department of Chemistry, Yasouj University, Yasouj 75914-353, Iran. karami@mail.yu.ac.ir
Montazerozohori
M
M
Habibi
M H
MH
D004220:Disulfides / Q000138:chemical synthesis*; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism*; D008299:Maleic Anhydrides / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D010084:Oxidation-Reduction / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism; D013696:Temperature; D014508:Urea / Q000737:chemistry / Q000378:metabolism*
D004220:Disulfides; D008299:Maleic Anhydrides; D013438:Sulfhydryl Compounds; D014508:Urea; D006861:Hydrogen Peroxide