New route to 3-alkylthiazolo[3,2-a]benzimidazole derivatives.
3-Alkyl-thiazolo[3,2-a]benzimidazole derivatives are obtained in high yields via the corresponding 4-alkyl-N-3-(2-aminophenyl)-thiazoline-2-thiones which are easily prepared from 1,2-diaminobenzene, CS(2) and halogenoketones. This new route compares advantageously with the classical mercaptobenzimidazole routes in term of simplicity,isolated yields and availability of the starting materials.
Roussel
Christian
C
UMR Chirotechnologies: Catalyse et Biocatalyse, Université Paul Cézanne Aix-Marseille III, 13397 Marseille CEDEX 20 France. Christian.roussel@univ.u-3mrs.fr
Andreoli
Federico
F
Roman
Mihaela
M
Hristova
Maria
M
Vanthuyne
Nicolas
N
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D008954:Models, Biological
D001562:Benzimidazoles; D006571:Heterocyclic Compounds