Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding transcription factor activated by multiple cytokines and interferons. High expression of STAT3 has also been implicated in cancer and lymphoma. Here, we show a case of B cell lymphoma in which a defective human immunodeficiency virus 1 (HIV-1) integrated upstream of the first STAT3 coding exon. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma. The provirus had a 5' long terminal repeat (LTR) deletion, but the 3' LTR had stronger promoter activity than the STAT3 promoter in reporter assays. Immunohistochemistry showed increased expression of STAT3 in the nuclei of lymphoma cells. Transfection of STAT3 resulted in transient cell proliferation in primary B cells in vitro. Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case.
Katano
Harutaka
H
Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. katano@nih.go.jp
Sato
Yuko
Y
Hoshino
Satomi
S
Tachikawa
Natsuo
N
Oka
Shinichi
S
Morishita
Yasuyuki
Y
Ishida
Takaomi
T
Watanabe
Toshiki
T
Rom
William N
WN
Mori
Shigeo
S
Sata
Tetsutaro
T
Weiden
Michael D
MD
Hoshino
Yoshihiko
Y
D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics* / Q000378:metabolism*; D016662:Virus Integration
D004279:DNA, Viral; D050796:STAT3 Transcription Factor