title: Screening of a combinatorial library reveals peptide-based catalysts for phosphorester cleavage in water.
abstract: A combinatorial library of 625 octapeptides was screened for their efficiency to catalyze phosphorester cleavage in water. Octapeptides such as 1c, which contains a catalytically active histidine and two cationic residues (Gua) as potential anion-binding sites, show substrate hydrolysis in water. Metal-free catalysis with a rate enhancement of up to a factor of 175 over the uncatalyzed background reaction is observed.
authors.affiliation: University of Würzburg, Institute of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany. schmuck@chemie.uni-wuerzburg.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
authors.forename: Jürgen
authors.initials: J
authors.lastname: Dudaczek
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D010455:Peptides / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004952:Esters; D010455:Peptides; D014867:Water