title: High resolution regional elasticity mapping of the human prostate.
abstract: What is it that the clinician "feels" during a digital rectal examination? To answer this question, it is necessary to measure the elastic properties of the prostate and verify the stiffness values with histological examination. Therefore, we devised an Elasticity Mapping System to evaluate the elastic properties of various histopathological grades of prostate cancer in relation to benign prostatic hyperplasia (BPH) and normal tissue. The system consists of a micro tactile sensor, a three-axis (XYZ) with one (fine Z) micromanipulation stage, a stereoscope camera and a measurement chamber. Using this methodology we mapped the elasticity of human prostate cancer (CaP) and it was obviously observed that the node was significantly harder than surrounding normal tissues and had some textures.
authors.affiliation: College of Engineering, Nihon University, Koriyama, Fukushima, 9638642 Japan. murayama@ee.ce.nihon-u.ac.jp
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Murayama
authors.forename: Sadao
authors.initials: S
authors.lastname: Omata
authors.forename: Toshikuni
authors.initials: T
authors.lastname: Yajima
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Peng
authors.forename: Keiichi
authors.initials: K
authors.lastname: Shishido
authors.forename: Donna M
authors.initials: DM
authors.lastname: Peehl
authors.forename: Christos E
authors.initials: CE
authors.lastname: Constantinou
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D004548:Elasticity; D006801:Humans; D008297:Male; D010173:Palpation / Q000295:instrumentation* / Q000379:methods; D010812:Physical Stimulation / Q000295:instrumentation* / Q000379:methods; D011467:Prostate / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical