A Reverse genetics system for dsRNA viruses.
The advent of a new reverse genetics system for reoviruses, described in this issue of Cell Host & Microbe by Kobayashi et al., opens new horizons of investigation into the molecular mechanisms governing dsRNA virus replication and pathogenesis. The elegant approach for recombinant reovirus recovery from a set of plasmid DNAs provides a template for designing similar reverse genetics systems for other dsRNA viruses associated with considerable morbidity and mortality in humans.
Baric
Ralph S
RS
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@emai.unc.edu
Sims
Amy C
AC
D016679:Genome, Viral; D012328:RNA Viruses / Q000235:genetics* / Q000276:immunology; D012087:Reoviridae / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
D014614:Vaccines, Synthetic; D014765:Viral Vaccines