Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance.
CTL express lytic proteins that mediate the cytolysis of virus-infected cells. In this study, cytolytic transcriptional profiles were determined for individual CTL responding to influenza A virus and HSV-1. During acute infection, influenza-specific CTL in the spleen and respiratory airways displayed highly activated cytolytic profiles, as did HSV-1-specific CTL localized in the spleen, skin, and dorsal root ganglia (DRG). In contrast, memory CTL dramatically down-regulated cytolytic molecule transcription. This occurred for both lymphoid (spleen) and tissue-resident (skin and/or lung) memory CTL. In contrast, HSV-1-specific CTL localized in the dorsal root ganglia in the presence latent HSV-1 Ag did not down-regulate cytolytic molecule transcription. Therefore, both lymphoid and tissue-resident memory CTL down-regulate cytolytic molecule transcription following virus clearance unless localized Ag is present.
Mintern
Justine D
JD
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
Guillonneau
Carole
C
Carbone
Francis R
FR
Doherty
Peter C
PC
Turner
Stephen J
SJ
D000818:Animals; D003602:Cytotoxicity, Immunologic; D015536:Down-Regulation / Q000276:immunology; D020869:Gene Expression Profiling; D053804:Granzymes / Q000235:genetics* / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology*; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D016133:Polymerase Chain Reaction / Q000379:methods; D052899:Pore Forming Cytotoxic Proteins / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000821:virology; D014158:Transcription, Genetic / Q000235:genetics / Q000276:immunology
D052899:Pore Forming Cytotoxic Proteins; C483886:perforin, mouse; D053804:Granzymes