title: Synthesis of polysubstituted cyclopentenones via [4+1] reactions of TIPS-vinylketenes.
abstract: An efficient method for preparing a series of polysubstituted cyclopentenones from TIPS-vinylketenes and Köbrich reagent has been developed in this paper. Additionally, highly substituted cyclopentenones can be prepared via [4+1] reaction of TIPS-vinylketenes with tert-butyl isocyanide and there is a remarkable preference for formation of products with an exocyclic (Z)-imine moiety.
authors.affiliation: Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: William H
authors.initials: WH
authors.lastname: Moser
authors.forename: Ruixue
authors.initials: R
authors.lastname: Deng
authors.forename: Liangdong
authors.initials: L
authors.lastname: Sun
mesh_terms: D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D017646:Organosilicon Compounds; D014753:Vinyl Compounds; C013905:cyclopentenone