Intercepting host MAPK signaling cascades by bacterial type III effectors.
The evolutionarily conserved MAP kinase (MAPK) cascades play essential roles in plant and animal innate immunity. A recent explosion of research has uncovered a myriad of virulence strategies used by pathogenic bacteria to intercept MAPK signaling through diverse type III effectors injected into host cells. Here, we review the latest literature and discuss the various mechanisms that pathogenic bacteria use to manipulate host MAPK signaling cascades.
Shan
Libo
L
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
He
Ping
P
Sheen
Jen
J
D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000276:immunology*; D010944:Plants; D021381:Protein Transport; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D037521:Virulence Factors