title: Simple segmental resection of the second portion of the duodenum for the treatment of gastrointestinal stromal tumors.
abstract: BACKGROUND
  Adequate surgical procedure for gastrointestinal stromal tumors (GISTs) arising in the second portion of the duodenum remains controversial.
  
  
  METHODS
  Segmental resection of the second portion of the duodenum and Roux-en-Y reconstruction was performed in two patients with duodenal GISTs. In case 1, a huge tumor arising from the second portion of the duodenum occupied the right upper quadrant of the abdomen. Preoperative treatment using imatinib mesylate decreased the tumor size from 22 to 8 cm. In case 2, the tumor was located in the second portion of the duodenum longitudinally. In both of the cases, the major papilla was preserved.
  
  
  RESULTS
  The postoperative course was uneventful, and they were discharged on day 11. Surgical margins were negative.
  
  
  CONCLUSIONS
  The present simple segmental duodenectomy can be applied in the treatment of GISTs or other low-grade malignancies.
authors.affiliation: Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Asakawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nara
authors.forename: Minoru
authors.initials: M
authors.lastname: Esaki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Tomoo
authors.initials: T
authors.lastname: Kosuge
mesh_terms: D000368:Aged; D000713:Anastomosis, Roux-en-Y; D001549:Benzamides; D004379:Duodenal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D020360:Neoadjuvant Therapy; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate