[The biological effects of very low-doses of ionizing radiation at the occupational exposure level].
The knowledge of the biological effects of very low-doses of ionizing radiation is of particular interest in order to estimate the risk for occupational workers. The epidemiological studies are to date insufficient to predict the risk for doses below 100 mSv. The cellular and molecular interaction of ionizing radiation with the cells, and the mechanisms involved in cell defence allow understanding the cellular response to radiation. The transcriptome analysis in the range of low doses has shown different cell responses according to the dose and dose rate. Here are presented the cellular and molecular action of ionizing radiation, the cellular mechanisms of cell defence and their modulation by the dose and dose rate. A non-linear relationship is drawn in this area.
Courtade-Saïdi
M
M
Laboratoire d'histologie-embryologie, faculté de médecine Toulouse-Rangueil, 133, route de Narbonne, 31062 Toulouse cedex 9, France. courtade@cict.fr
D002468:Cell Physiological Phenomena; D002477:Cells / Q000528:radiation effects; D003359:Cosmic Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D016273:Occupational Exposure; D011839:Radiation, Ionizing; D012307:Risk Factors