[Perioperative changes of the coagulation markers in patients undergoing hip fracture surgery].
BACKGROUND
Plasma levels of D-dimer, fibrin monomer complex (FMC) and FDP were measured in 10 patients who underwent hip fracture surgery, using a recently established monoclonal antibody to clarify if these markers are good indicators of deep vein thrombosis (DVT).


METHODS
Subjects were 10 (4 male and 6 female) hip fracture patients, aged 87 +/- 6 years. D-dimer, FMC and FDP were measured at induction of anesthesia and 24 hours as well as 6 days after operation.


RESULTS
Preoperative values of D-dimer, FMC and FDP were higher than normal values, and these markers remained high during the postoperative period.


CONCLUSIONS
It is concluded that plasma levels of D-dimer, FMC and FDP in the patients with hip fracture were high in perioperative period. Among these markers, FMC was the most useful indicator for the diagnosis at the early stage of DVT.
Okamura
Kenta
K
Department of Anesthesia and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
Nakagawa
Itsuo
I
Hidaka
Syozo
S
Okada
Yasunori
Y
Kubo
Takashi
T
Kato
Takahiro
T
D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D020246:Venous Thrombosis / Q000097:blood*
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; C011468:fibrinmonomer