title: A framework for fuzzy expert system creation--application to cardiovascular diseases.
abstract: A methodology for the automated development of fuzzy expert systems is presented. The idea is to start with a crisp model described by crisp rules and then transform them into a set of fuzzy rules, thus creating a fuzzy model. The adjustment of the model's parameters is performed via a stochastic global optimization procedure. The proposed methodology is tested by applying it to problems related to cardiovascular diseases, such as automated arrhythmic beat classification and automated ischemic beat classification, which, besides being well-known benchmarks, are of particular interest due to their obvious medical diagnostic importance. For both problems, the initial set of rules was determined by expert cardiologists, and the MIT-BIH arrhythmia database and the European ST-T database are used for optimizing the fuzzy model's parameters and evaluating the fuzzy expert system. In both cases, the results indicate an escalation of the performance from the simple initial crisp model to the more sophisticated fuzzy models, proving the scientific added value of the proposed framework. Also, the ability to interpret the decisions of the created fuzzy expert systems is a major advantage compared to "black box" approaches, such as neural networks and other techniques.
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, University of Ioannina, GR 45110 Ioannina, Greece. markos@cs.uoi.gr
authors.forename: Markos G
authors.initials: MG
authors.lastname: Tsipouras
authors.forename: Costas
authors.initials: C
authors.lastname: Voglis
authors.forename: Dimitrios I
authors.initials: DI
authors.lastname: Fotiadis
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000175:diagnosis*; D002318:Cardiovascular Diseases / Q000175:diagnosis; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005103:Expert Systems; D017143:Fuzzy Logic; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity