Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.
Hsp90 is a cytosolic molecular chaperone whose paralog in mitochondria, TRAP1, protects cells from oxidative stress. The recent study in Cell by Kang et al. now identifies the molecular components of the proapoptotic network regulated by TRAP1, that includes Hsp90. Targeting Hsp90/TRAP1 inhibitors to mitochondria induces rapid tumor cell-specific apoptosis.
Neckers
Len
L
Urologic Oncology Branch, Center for Cancer Research, NCI, 9000 Rockville Pike, Bldg. 10/CRC, Room 1-5940, Bethesda, MD 20892, USA. len@helix.nih.gov
Kern
Adam
A
Tsutsumi
Shinji
S
D017209:Apoptosis; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*
D018841:HSP90 Heat-Shock Proteins