Protective immune mechanisms in helminth infection.
Important insights have recently been gained in our understanding of how host immune responses mediate resistance to parasitic helminths and control associated pathological responses. Although similar cells and cytokines are evoked in response to infection by helminths as diverse as nematodes and schistosomes, the components of the response that mediate protection are dependent on the particular parasite. In this Review, we examine recent findings regarding the mechanisms of protection in helminth infections that have been elucidated in murine models and discuss the implications of these findings in terms of future therapies.
Anthony
Robert M
RM
The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Rutitzky
Laura I
LI
Urban
Joseph F
JF
Stadecker
Miguel J
MJ
Gause
William C
WC
D000818:Animals; D001491:Basophils / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000502:physiology; D006099:Granuloma / Q000276:immunology; D006373:Helminthiasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000502:physiology; D009504:Neutrophils / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines