title: Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.
abstract: Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.
authors.affiliation: Shibaura institute of technology, Department of applied chemistry, Toyosu 3-7-5, Koutou-ku, Tokyo 138-8548, Japan.
authors.forename: Kenatarou
authors.initials: K
authors.lastname: Watanabe
authors.forename: Toyofusa
authors.initials: T
authors.lastname: Katou
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ikezawa
authors.forename: Saki
authors.initials: S
authors.lastname: Yajima
authors.forename: Hirohito
authors.initials: H
authors.lastname: Shionoya
authors.forename: Takashi
authors.initials: T
authors.lastname: Akagi
authors.forename: Keita
authors.initials: K
authors.lastname: Hamasaki
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D005601:Framycetin / Q000737:chemistry*; D016325:HIV Long Terminal Repeat; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry*
chemical_list: D000617:Aminoglycosides; D011687:Purines; D011743:Pyrimidines; D012367:RNA, Viral; D005601:Framycetin; C488396:neamine