Microarray simulator as educational tool.
As many real-world applications, microarray measurements are inapplicable for large-scale teaching purposes due to their laborious preparation process and expense. Fortunately, many phases of the array preparation process can be efficiently demonstrated by using a software simulator tool. Here we propose the use of microarray simulator as an aiding tool in teaching of computational biology. Three case studies on educational use of the simulator are presented, which demonstrate the effect of gene knock-out, synthetic time series, and effect of noise sources. We conclude that the simulator, used for teaching the principles of microarray measurement technology, proved to be a useful tool in education.
Ruusuvuori
Pekka
P
Institute of Signal Processing, Tampere University of Technology, P.O.Box 553, 33101 Tampere, Finland. pekka.ruusuvuori@tut.fi
Nykter
Matti
M
Mäkiraatikka
Eeva
E
Lehmussola
Antti
A
Korpelainen
Tomi
T
Erkkilä
Timo
T
Yli-Harja
Olli
O
D001709:Biotechnology / Q000193:education* / Q000379:methods; D003198:Computer Simulation; D003194:Computer-Assisted Instruction / Q000379:methods*; D005387:Finland; D020869:Gene Expression Profiling / Q000379:methods*; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software; D014584:User-Computer Interface