[The relationship between cbfalpha1 and the mechanism of the bone remodeling in the process of orthodontic tooth movement].
OBJECTIVE
To perform qualitative and quantitative analyses of core binding factor alpha1 (cbfalpha1) in periodontal tissue during the experimental rat tooth movement process and to investigate the active mechanism of cbfalpha1 in the osteoblast differentiation.


METHODS
42 male Wistar rats aged 8 weeks were divided into 7 groups (0,1,3,5,7,10 and 14 days groups) in random, 6 rats in each group. 42 rats were perfused and sacrificed at the 1st, 3rd, 5th, 7th, 10th and 14th day. All specimens were fixed, then proceeded with HE and cbfalpha1 immunohistochemical staining. The results were analyzed by SPSS11.0 software package for Dunnett test, and the histological changes of cbfalpha1 in periodontal tissue were evaluated.


RESULTS
In the periodontal ligament(PDL) of non orthodontic treatment group, the expression of cbfalpha1 was lower; the expression of cbfalpha1 in every experimental groups increased firstly and decreased later; the expression of cbfalpha1 in the surface of the alveolar bone was lower in the compression side than in the tension side, and the number of positive cells was less too (P<0.01).


CONCLUSIONS
cbfalpha1 participates in the process of bone remodeling during the process of orthodontic tooth movement, and it promotes the remodeling and stability of PDL.
Shi
Han
H
Department of Orthodontics,West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China.
Chen
Yuan-ping
YP
Shi
Rui-xin
RX
Han
Guang-hong
GH
Chen
Yang-xi
YX
D000818:Animals; D016723:Bone Remodeling; D050657:Core Binding Factor alpha Subunits / Q000378:metabolism*; D008297:Male; D010010:Osteoclasts; D010513:Periodontal Ligament; D010519:Periodontium; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
D050657:Core Binding Factor alpha Subunits; C406688:core binding factor alpha