title: Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease.
abstract: Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.
authors.affiliation: Mayo Clinic College of Medicine, Rochester, MN, United States.
authors.forename: Jon L
authors.initials: JL
authors.lastname: Belsher
authors.forename: Peter
authors.initials: P
authors.lastname: Gay
authors.forename: Margo
authors.initials: M
authors.lastname: Brinton
authors.forename: Joseph
authors.initials: J
authors.lastname: DellaValla
authors.forename: Robert
authors.initials: R
authors.lastname: Ridenour
authors.forename: Robert
authors.initials: R
authors.lastname: Lanciotti
authors.forename: Andrey
authors.initials: A
authors.lastname: Perelygin
authors.forename: Sherif
authors.initials: S
authors.lastname: Zaki
authors.forename: Christopher
authors.initials: C
authors.lastname: Paddock
authors.forename: Troy
authors.initials: T
authors.lastname: Querec
authors.forename: Tuofu
authors.initials: T
authors.lastname: Zhu
authors.forename: Bali
authors.initials: B
authors.lastname: Pulendran
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Eidex
authors.forename: Edward
authors.initials: E
authors.lastname: Hayes
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology*; D015004:Yellow Fever / Q000517:prevention & control; D022341:Yellow Fever Vaccine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D022341:Yellow Fever Vaccine