Role of Thy-1,2+ cells in the regulation of hemopoiesis during severe hypoxia.
We studied the state of the bone marrow Thy-1,2+ cell pool under conditions of severe hypoxia. T cell mechanisms of hemopoiesis regulation are preserved under conditions of severe oxygen deficiency due to changes in functional properties of Thy-1,2+ cells. We revealed an indirect (mediated through cooperation with adherent myelokaryocytes) stimulating effect of Thy-1,2+ cells on erythroid precursors as well as direct and indirect feeder effects of these cells on granulocyte-monocyte precursors.
Goldberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Dygai
A M
AM
Zyuz'kov
G N
GN
D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology; D000818:Animals; D001362:Avoidance Learning; D001810:Blood Volume; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002448:Cell Adhesion; D015672:Erythroid Precursor Cells / Q000473:pathology / Q000502:physiology; D042381:Granulocyte Precursor Cells / Q000473:pathology / Q000502:physiology; D006410:Hematopoiesis; D006885:Hydroxybutyrates / Q000494:pharmacology; D000860:Hypoxia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008568:Memory; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000502:physiology; D018800:Thy-1 Antigens / Q000378:metabolism*
D006885:Hydroxybutyrates; D018800:Thy-1 Antigens