title: Influence of selected factors on occurrence of delayed kidney graft function: a multivariate analysis.
abstract: Efficient urine production after kidney transplantation is often evidence of good graft function. If severe organ injury occurs, we have oliguria or anuria and the patient requires postoperative hemodialysis. In most cases, graft function recovers after a few hemodialysis treatments-delayed graft function (DGF). Therefore, recognition of factors influencing the onset of DGF is crucial. We examined the state of the circulatory system by a thermodilution method in 101 organ donors, taking into account mean arterial pressure (MAP), central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), systemic vascular resistance index. We also examined 232 kidney recipients, based on age, gender, panel-reactive antibody, cold ischemia time, and reason for renal insufficiency. We defined DGF as at least one hemodialysis after kidney transplantation. In logistic regression analysis, we showed that donor MAP, CVP, and PCWP of the substantially influenced the occurrence of DGF among kidney transplant recipients. Maintaining an adequate MAP and a sufficient volume in the donor circulatory system substantially decreased the occurrence of DGF after kidney transplantation.
authors.affiliation: Clinic of Anaesthesiology and Intensive Care, Pomeranian Medical University, Szczecin, Poland. zukowski@sci.pam.szczecin.pl
authors.forename: M
authors.initials: M
authors.lastname: Zukowski
authors.forename: R
authors.initials: R
authors.lastname: Bohatyrewicz
authors.forename: A A
authors.initials: AA
authors.lastname: Krawczyk
mesh_terms: D000328:Adult; D001002:Anuria / Q000209:etiology; D001794:Blood Pressure; D002423:Cause of Death; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009846:Oliguria / Q000209:etiology; D011652:Pulmonary Circulation / Q000502:physiology; D012044:Regression Analysis; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data