[Preparation of gemcitabine polybutylcyanoacrylate nanoparticles].
OBJECTIVE
To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).


METHODS
According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.


RESULTS
The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.


CONCLUSIONS
An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.
Huang
Le-song
LS
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hls83@fimmu.com
Wang
Chun-xia
CX
Chen
Zhi-liang
ZL
Wan
Jia
J
Yan
Xi-qing
XQ
Duan
Gang
G
D002626:Chemistry, Pharmaceutical; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D016503:Drug Delivery Systems; D004659:Enbucrilate / Q000138:chemical synthesis*; D053758:Nanoparticles / Q000737:chemistry*; D000093542:Gemcitabine
D003841:Deoxycytidine; D004659:Enbucrilate; D000093542:Gemcitabine