title: Nramp1 phagocyte intracellular metal withdrawal defense.
abstract: Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases.
authors.affiliation: INRS-Institut Armand-Frappier, 531, Bd des prairies, Laval, Québec H7V 1B7, Canada. mathieu.cellier@iaf.inrs.ca
authors.forename: Mathieu F
authors.initials: MF
authors.lastname: Cellier
authors.forename: Pascal
authors.initials: P
authors.lastname: Courville
authors.forename: Carole
authors.initials: C
authors.lastname: Campion
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D027682:Cation Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D005057:Eukaryotic Cells / Q000276:immunology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008345:Manganese / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism*; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D027682:Cation Transport Proteins; D007501:Iron; D008345:Manganese; D000099173:Natural Resistance-associated Macrophage Protein 1