title: N,N'-SUBStituted 1,2,5 thiadiazolidine 1,1-dioxides: synthesis, selected chemical and spectral proprieties and antimicrobial evaluation.
abstract: The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.
authors.affiliation: Laboratoire de Chimie Organique Appliquée, Groupe de Chimie Bioorganique, Faculté des Sciences, Département de Chimie, Université d' Annaba. Algeria.
authors.forename: Amel
authors.initials: A
authors.lastname: Bendjeddou
authors.forename: Ryad
authors.initials: R
authors.lastname: Djeribi
authors.forename: Zine
authors.initials: Z
authors.lastname: Regainia
authors.forename: Nour-Eddine
authors.initials: NE
authors.lastname: Aouf
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000737:chemistry*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D013830:Thiadiazoles