[Effects of sapindoside on blood pressure and vasoactive substance in renovascular hypertension rat].
OBJECTIVE
To observe the effects of sapindoside on blood pressure, Ang II, Ald, ET in the blood plasma and NO in the serum in renovascular hypertension rat.


METHODS
The 2K1C (2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 5 weeks. The blood pressure was measured at the 1, 3, 7, 14, 21, 28, 35 day after drug. At the end of 5th weeks, the Ang II, Ald, ET in the blood plasma and NO in the serum were measured.


RESULTS
Sapindoside (H, M and L) by ig. for 5 weeks could significantly lower the blood pressure, increase the levels of NO in the serum, reduce the concentration of Ang II, Ald, ET in the blood plasma.


CONCLUSIONS
Sapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.
Wang
Wei-sheng
WS
Anhui College of Traditional Chinese Medicine, Hefei 230038, China.
Long
Zi-jiang
ZJ
Zhang
Ling
L
Bian
Hai
H
Wang
Liang
L
Chen
Ming
M
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D016232:Endothelins / Q000097:blood; D005260:Female; D006978:Hypertension, Renovascular / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032127:Sapindus / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D012503:Saponins; C460644:kalopanax saponin A; D000804:Angiotensin II; D009569:Nitric Oxide; D000450:Aldosterone; D009828:Oleanolic Acid