Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy.
Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.
Arbibe
Laurence
L
Unité de Pathogénie Microbienne Moléculaire and Unité INSERM 786, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. arbibe@pasteur.fr
Sansonetti
Philippe J
PJ
D016207:Cytokines / Q000502:physiology; D015195:Drug Design; D004361:Drug Tolerance; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000633:toxicity*; D051197:Toll-Like Receptor 4 / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
D016207:Cytokines; D008070:Lipopolysaccharides; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors