title: Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer.
abstract: BACKGROUND
  The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases.
  
  
  METHODS
  The variables considered included disease stage, differentiation grade, site and nodal metastasis of the primary tumor, number and diameter of the lesions, time from primary cancer to metastasis, preoperative carcinoembryonic antigen (CEA) level, adjuvant chemotherapy, type of resection, intraoperative ultrasonography and portal clamping use, blood loss, transfusions, complications, hospitalization, surgical margins status, and a clinical risk score (MSKCC-CRS).
  
  
  RESULTS
  The univariate analysis revealed a significant difference (p < 0.05) in overall 5-year survival rates depending on the differentiation grade, preoperative CEA >5 and >200 ng/ml, diameter of the lesion >5 cm, time from primary tumor to metastases >12 months, MSKCC-CRS >2. The multivariate analysis showed three independent negative prognostic factors: G3 or G4 grade, CEA >5 ng/ml, and high MSKCC-CRS.
  
  
  CONCLUSIONS
  No single prognostic factor proved to be associated with a sufficiently disappointing outcome to exclude patients from liver resection. However, in the presence of some prognostic factors (G3-G4 differentiation, preoperative CEA >5 ng/ml, high MSKCC-CRS), enrollment of patients in trials exploring new adjuvant treatments is suggested to improve the outcome after surgery.
authors.affiliation: Department of Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. arru.marcella@hsr.it
authors.forename: Marcella
authors.initials: M
authors.lastname: Arru
authors.forename: Luca
authors.initials: L
authors.lastname: Aldrighetti
authors.forename: Renato
authors.initials: R
authors.lastname: Castoldi
authors.forename: Saverio
authors.initials: S
authors.lastname: Di Palo
authors.forename: Elena
authors.initials: E
authors.lastname: Orsenigo
authors.forename: Marco
authors.initials: M
authors.lastname: Stella
authors.forename: Carlo
authors.initials: C
authors.lastname: Pulitanò
authors.forename: Francesca
authors.initials: F
authors.lastname: Gavazzi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferla
authors.forename: Valerio
authors.initials: V
authors.lastname: Di Carlo
authors.forename: Carlo
authors.initials: C
authors.lastname: Staudacher
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome