Division of labor: minor splicing in the cytoplasm.
There are two molecular machineries for pre-mRNA splicing-the major spliceosome and the minor spliceosome. In this issue of Cell, König et al. (2007) demonstrate that the two splicing pathways are spatially separated in the cell and may have distinct functions.
Caceres
Javier F
JF
MRC Human Genetics Unit, Edinburgh, UK. javier.caceres@hgu.mrc.ac.uk
Misteli
Tom
T
D003593:Cytoplasm / Q000378:metabolism*; D007438:Introns; D012322:RNA Precursors / Q000378:metabolism; D012326:RNA Splicing; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism; D017381:Spliceosomes / Q000378:metabolism*
D012322:RNA Precursors; D017411:Ribonucleoproteins, Small Nuclear