Radiation-induced one-electron reduction of oligodeoxynucleotides possessing disulfide bond.
Hypoxic X-radiolysis of diluted aqueous solution was performed to generate hydrated electrons that induced one-electron reduction of oligodeoxynucleotides (ODN) possessing a disulfide bond. The disulfide bond was cleaved into thiols, which underwent subsequent reoxidation to produce three forms of disulfide ODNs via intermolecular strand crossing.
Kuraseko
Emi
E
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
Tanabe
Kazuhito
K
Nishimoto
Sei-Ichi
S
D002851:Chromatography, High Pressure Liquid; D004220:Disulfides / Q000737:chemistry*; D004583:Electrons; D008970:Molecular Weight; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000528:radiation effects; D010084:Oxidation-Reduction; D014867:Water / Q000737:chemistry
D004220:Disulfides; D009838:Oligodeoxyribonucleotides; D014867:Water