title: BAFfled by poxviruses?
abstract: Successful viruses engage in a dynamic interplay with their hosts, where both utilize diverse strategies to impose their supremacy. In this issue of Cell Host & Microbe, Wiebe and Traktman describe a novel interaction between vaccinia virus and mammalian cells. A host protein called BAF can bind ectopic cytoplasmic DNA and block viral DNA replication, whereas vaccinia in turn counteracts this inhibition with a virus-encoded serine threonine kinase that inactivates BAF.
authors.affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1600 Southwest Archer Road, P.O. Box 100332, Gainesville, FL 32610, USA.
authors.forename: Masmudur M
authors.initials: MM
authors.lastname: Rahman
authors.forename: Grant
authors.initials: G
authors.lastname: McFadden
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans / Q000276:immunology / Q000821:virology; D014616:Vaccinia virus / Q000201:enzymology* / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins