Chronic kidney disease as a risk factor for coronary artery disease in Chinese with type 2 diabetes.
BACKGROUND
Chronic kidney disease (CKD) is associated with cardiovascular disease (CVD) in the general population. We investigated the effects of renal function on coronary artery disease (CAD) in Chinese with type 2 diabetes who have a high risk of developing diabetic nephropathy but who may have a low risk of developing CAD.


METHODS
We recruited a total of 2,434 Chinese with type 2 diabetes (1,078 men and 1,356 women) and diagnosed CAD by history or with an abnormal electrocardiogram (coronary probable or possible by Minnesota codes). Renal function was evaluated by serum creatinine (SCr) levels, estimated glomerular filtration rate (eGFR) (calculated by the abbreviated Modification of Diet in Renal Disease Study Croup formula) and urinary albumin/creatinine ratio (ACR).


RESULTS
We found that patients with CAD were older, had higher SCr levels and body mass index (BMI), and had lower serum high-density lipoprotein cholesterol (HDL-c) levels. After adjusting for age, BMI, blood pressure, glycosylated hemoglobin, cholesterol, LDL-c, HDL-c, and triglycerides, we found that SCr levels >1.5 mg/dl, eGFR <60 ml/min, and urinary ACR >30 mg/g were independent risk factors for CAD in diabetic men, and that SCr levels >1.4 mg/dl and eGFR <60 ml/min were independently associated with CAD in women.


CONCLUSIONS
Our findings indicate that Chinese with type 2 diabetes and CKD are likely to have had CAD previously and CKD is 'CVD risk state' in diabetic Chinese.
Hsieh
Ming-Chia
MC
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hsiao
Jeng-Yueh
JY
Tien
Kai-Jen
KJ
Chang
Shun-Jen
SJ
Hsu
Shih-Chieh
SC
Liang
Hui-Ting
HT
Chen
Hung-Chun
HC
Lin
Shiu-Ru
SR
Tu
Shih-Te
ST
D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D002681:China; D003324:Coronary Artery Disease / Q000150:complications* / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors