title: Poly[3-(3,4-dihydroxyphenyl)glyceric acid], a new biologically active polymer from Symphytum asperum Lepech. and S. caucasicum Bieb. (Boraginaceae).
abstract: Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], according to IR and NMR spectroscopy. The Symphytum high-molecular preparations can modulate in vitro B- chronic lymphocytic leukaemia (B-CLL) cells apoptosis and cell cycle progression.
authors.affiliation: Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences, Georgia. v_barbakadze@hotmail.com
authors.forename: Vakhtang
authors.initials: V
authors.lastname: Barbakadze
authors.forename: Etheri
authors.initials: E
authors.lastname: Kemertelidze
authors.forename: Iraida
authors.initials: I
authors.lastname: Targamadze
authors.forename: Karen
authors.initials: K
authors.lastname: Mulkijanyan
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Shashkov
authors.forename: Anatolii I
authors.initials: AI
authors.lastname: Usov
mesh_terms: D001704:Biopolymers / Q000737:chemistry / Q000302:isolation & purification; D028082:Boraginaceae / Q000737:chemistry*; D002247:Carbon Isotopes; D002460:Cell Line; D005988:Glyceric Acids / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
chemical_list: D001704:Biopolymers; D002247:Carbon Isotopes; D005988:Glyceric Acids; D011522:Protons; C525096:poly(3-(3,4-dihydroxyphenyl)glyceric acid); C042971:glyceric acid