title: Sequential copper-catalyzed vinylation/cyclization: an efficient synthesis of functionalized oxazoles.
abstract: A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
authors.affiliation: Department of Chemistry, Massachusetts Instituteof Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Rubén
authors.initials: R
authors.lastname: Martín
authors.forename: Ana
authors.initials: A
authors.lastname: Cuenca
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010080:Oxazoles; D003300:Copper