Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments.
To address the specific challenges of cancer therapy and diagnosis, a number of approaches have been advocated for the development of tumor-targeting antitumor drugs/prodrugs and non-invasive tumor molecular imaging probes. These intelligent drugs and probes are constructed from multi-functional molecular systems. This review focuses on the molecular design of drugs and imaging probes that target tumor-specific microenvironments such as angiogenesis and hypoxia.
Tanabe
Kazuhito
K
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
Zhang
Zhouen
Z
Ito
Takeo
T
Hatta
Hiroshi
H
Nishimoto
Sei-ichi
S
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects; D015195:Drug Design; D015335:Molecular Probes; D009369:Neoplasms / Q000098:blood supply; D011355:Prodrugs / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D015335:Molecular Probes; D011355:Prodrugs