title: Bioactive polychlorinated bibenzyls from the liverwort Riccardia polyclada.
abstract: GC-MS and (1)H NMR spectroscopic profiling of a CDCl 3 extract of the liverwort Riccardia polyclada (syn. R. umbrosa) revealed the presence of four main compounds bearing several chlorine atoms on a bibenzyl skeleton. Separation of a CH 2Cl 2 extract was achieved using preparative TLC, and structures 1- 4 were proposed on the basis of spectroscopic evidence. Compounds 1- 4 were active in a brine shrimp lethality bioassay ( Artemia salina). In addition, 2 and 4 displayed moderate antifeedant activity in disk-choice bioassays with Spodoptera littoralis larvae and inhibited the growth of Cladosporium herbarum cultures on TLC plates.
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. clabbe@uchile.cl
authors.forename: Cecilia
authors.initials: C
authors.lastname: Labbé
authors.forename: Francesca
authors.initials: F
authors.lastname: Faini
authors.forename: Carolina
authors.initials: C
authors.lastname: Villagrán
authors.forename: Josep
authors.initials: J
authors.lastname: Coll
authors.forename: David S
authors.initials: DS
authors.lastname: Rycroft
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects*; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002677:Chile; D002963:Cladosporium / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D035926:Hepatophyta / Q000737:chemistry*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018411:Spodoptera / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D001632:Bibenzyls; D011078:Polychlorinated Biphenyls