The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.
A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.
Bertrand
Hélène
H
Institut Curie, Section Recherche, CNRS UMR176, Centre Universitaire Paris XI, Bât. 110, 91405 Orsay, France.
Monchaud
David
D
De Cian
Anne
A
Guillot
Régis
R
Mergny
Jean-Louis
JL
Teulade-Fichou
Marie-Paule
MP
D001667:Binding, Competitive; D018360:Crystallography, X-Ray; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D011725:Pyridines