title: Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes.
abstract: Marrow fibrosis (MF) has rarely been studied in myelodysplastic syndromes (MDS). There are no data on occurrence and significance of MF in the context of the World Health Organization (WHO) classification of disease. In total, 349 bone marrow biopsies from 200 patients with primary MDS were examined for MF and its prognostic relevance. MF correlated with multilineage dysplasia, more severe thrombopenia, higher probability of a clonal karyotype abnormality, and higher percentages of blasts in the peripheral blood (P<0.002). Its frequency varied markedly between different MDS types ranging from 0 (RARS) to 16% (RCMD, RAEB, P<0.007). Two patients with MF showed a Janus kinase-2 mutation (V617F). Patients with MF suffered from marrow failure significantly earlier with shortening of the survival time down to 0.5 (RAEB-1/-2), and 1-2 (RCMD, RA) years in median (P<0.00005). The prognostic relevance of MF was independent of the International Prognostic Scoring System and the classification of disease.
  
  
  CONCLUSIONS
  The risk of MF Differs markedly between various subtypes of MDS. MF indicates an aggressive course with a significantly faster progression to fatal marrow failure and should therefore be considered in diagnosis, prognosis and treatment of disease.
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Hannover, Germany. guntram.buesche@arcor.de
authors.forename: G
authors.initials: G
authors.lastname: Buesche
authors.forename: H
authors.initials: H
authors.lastname: Teoman
authors.forename: W
authors.initials: W
authors.lastname: Wilczak
authors.forename: A
authors.initials: A
authors.lastname: Ganser
authors.forename: H
authors.initials: H
authors.lastname: Hecker
authors.forename: L
authors.initials: L
authors.lastname: Wilkens
authors.forename: G
authors.initials: G
authors.lastname: Göhring
authors.forename: B
authors.initials: B
authors.lastname: Schlegelberger
authors.forename: O
authors.initials: O
authors.lastname: Bock
authors.forename: A
authors.initials: A
authors.lastname: Georgii
authors.forename: H
authors.initials: H
authors.lastname: Kreipe
mesh_terms: D000368:Aged; D001855:Bone Marrow Diseases / Q000473:pathology*; D001856:Bone Marrow Examination; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate