Autophagy takes its TOLL on innate immunity.
Toll-like receptors (TLRs) activate a complimentary set of defense responses that protect cells during microbial infection. In the recent issue of Immunity, Xu et al. (2007) elucidate a molecular pathway that connects TLR4-mediated innate immune signaling to autophagy, a process of cytoplasmic sequestration and subsequent recycling or degradation.
Seay
Montrell D
MD
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.
Dinesh-Kumar
S P
SP
D000818:Animals; D001343:Autophagy / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051197:Toll-Like Receptor 4 / Q000276:immunology*
D051197:Toll-Like Receptor 4