title: The longitudinal relationship between lipid profile and physical capacity in persons with a recent spinal cord injury.
abstract: METHODS
  A multicenter prospective cohort study.
  
  
  OBJECTIVE
  To determine the longitudinal relationship between physical capacity and lipid profile in persons with spinal cord injury (SCI) during and 1 year after rehabilitation.
  
  
  METHODS
  Eight Dutch rehabilitation centers with a specialized SCI unit.
  
  
  METHODS
  A total of 206 subjects with SCI (78 with tetraplegia) participated. The longitudinal relationship between lipid profiles (total cholesterol (TC), high- (HDL) and low-density lipoprotein (LDL) and triglycerides (TG) and physical capacity (peak power output (POpeak), peak oxygen uptake (VO2peak), and muscle strength) was investigated during inpatient SCI rehabilitation (start, 3 months later, discharge) and 1 year after discharge. A correction was made for the possible confounding variables age, body mass index, gender, time since injury, lesion level and completeness.
  
  
  RESULTS
  HDL and the ratios LDL/HDL and TC/HDL showed a significant and favorable relationship with VO2peak, POpeak and muscle strength. TG was positively related to POpeak and muscle strength.
  
  
  CONCLUSIONS
  More favorable lipid profiles were seen in people with a higher physical capacity after correction for personal and lesion characteristics. Therefore, improving the physical capacity by being active during daily life or in sport may further improve the lipid profile and thus reduce the risk for coronary heart disease.
authors.affiliation: Rehabilitation Center Amsterdam, Amsterdam, The Netherlands. s.de.groot@fbw.vu.nl
authors.forename: S
authors.initials: S
authors.lastname: de Groot
authors.forename: A J
authors.initials: AJ
authors.lastname: Dallmeijer
authors.forename: M W M
authors.initials: MW
authors.lastname: Post
authors.forename: E L D
authors.initials: EL
authors.lastname: Angenot
authors.forename: L H V
authors.initials: LH
authors.lastname: van der Woude
mesh_terms: D000328:Adult; D015331:Cohort Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018908:Muscle Weakness / Q000209:etiology / Q000517:prevention & control / Q000534:rehabilitation; D009426:Netherlands; D010101:Oxygen Consumption; D010809:Physical Fitness; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000097:blood / Q000453:epidemiology / Q000534:rehabilitation*; D013995:Time; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008055:Lipids