title: Middle cerebral artery atherosclerosis: histological comparison between plaques associated with and not associated with infarct in a postmortem study.
abstract: BACKGROUND
  Atherosclerotic stenosis of large intracranial arteries, especially the middle cerebral artery (MCA), is a common cause of stroke in Chinese patients. We aimed to describe the morphological features of atherosclerotic stenosis in the MCA and to investigate their relationship with cerebral infarcts from a postmortem series.
  
  
  METHODS
  We studied the morphological features of the MCAs in consecutive postmortem adults aged 45 years or above. The following parameters were evaluated by a single observer blinded to the clinical history: (1) thickness of fibrous cap; (2) extent of lipid area; (3) degree of luminal stenosis; (4) presence of intraplaque hemorrhage, neovasculature, thrombus and calcification. A semiquantitative assessment of macrophage and T lymphocyte infiltration was made by immunohistochemical staining for CD68 and CD45RO.
  
  
  RESULTS
  Seventy-six cases were recruited. Atherosclerotic plaques of more than 40% cross-sectional area luminal narrowing stenosis were found in 69 MCAs (45.4%, 69/152). The results demonstrated that the degree of luminal stenosis, the percentage of the plaques containing more than 40% lipid area and the prevalence of intraplaque hemorrhage, neovasculature and thrombus were higher in those plaques associated with infarct, and the mean index of both CD45RO and CD68 was higher among those associated with infarct (p < 0.01). Binary logistic regression showed that stenosis (p = 0.003; odds ratio, OR = 1.050), lipid area (p = 0.048, OR = 1.698) and presence of neovasculature (p = 0.040, OR = 3.471) were independent risk factors of MCA infarcts.
  
  
  CONCLUSIONS
  Luminal stenosis caused by atherosclerotic plaque, percentage of lipid area and presence of intraplaque neovasculature may play a key role in leading to ischemic stroke.
authors.affiliation: Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. Fiona.xy2000@gmail.com
authors.forename: Xiang Yan
authors.initials: XY
authors.lastname: Chen
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
authors.forename: Wynnie Wai Man
authors.initials: WW
authors.lastname: Lam
authors.forename: Hai-Lu
authors.initials: HL
authors.lastname: Zhao
authors.forename: Ho Keung
authors.initials: HK
authors.lastname: Ng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D016022:Case-Control Studies; D005260:Female; D006723:Hong Kong; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology* / Q000473:pathology*; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors