title: LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium.
abstract: LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals.
authors.affiliation: Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
authors.forename: M H
authors.initials: MH
authors.lastname: Karavolos
authors.forename: D M
authors.initials: DM
authors.lastname: Bulmer
authors.forename: K
authors.initials: K
authors.lastname: Winzer
authors.forename: M
authors.initials: M
authors.lastname: Wilson
authors.forename: P
authors.initials: P
authors.lastname: Mastroeni
authors.forename: P
authors.initials: P
authors.lastname: Williams
authors.forename: C M A
authors.initials: CM
authors.lastname: Khan
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D013437:Carbon-Sulfur Lyases / Q000235:genetics / Q000378:metabolism*; D005407:Flagella / Q000737:chemistry* / Q000276:immunology; D005408:Flagellin / Q000276:immunology / Q000378:metabolism*; D017353:Gene Deletion; D005816:Genetic Complementation Test; D053038:Quorum Sensing; D012486:Salmonella typhimurium / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D005408:Flagellin; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria