Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax.
The effects of ACTH4-10 fragment and its analog semax on nociception were examined on various animal models. ACTH4-10 in a dose of 0.5 mg/kg decreased nociception in rats during hindpaw compression test and in mice subjected to acetic acid writhing test. Lower doses of ACTH4-10 produced no analgesic effect. Semax (0.015-0.500 mg/kg) decreased pain sensitivity in all experimental models. Hence, the substitution of three C-terminal amino acid residues in ACTH4-10 for Pro-Gly-Pro sequence augmented the analgesic potency of the peptide after its peripheral injection.
Ivanova
D M
DM
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Levitskaya
N G
NG
Andreeva
L A
LA
Kamenskii
A A
AA
Myasoedov
N F
NF
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)