title: The haemodynamic response to the interictal epileptic spikes.
abstract: We studied the blood oxygen level dependent (BOLD) response to interictal epileptic spikes in a group of patients with focal epilepsy by simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). The detection of activated areas was performed by using an approach based on the theory of the General Linear Models (GLM). Since little is know about the haemodynamic response to the interictal epileptiform activity, for each region involved by fMRI response and for each subject we obtained a robust estimation of the haemodynamic response function (HRF) by using a Bayesian approach. We observed important variations in the time course of the haemodynamic response between patients and across the different fMRI areas of a same subject.
authors.affiliation: Department of Biomedical Engineering, IIT Unit, Polytechnic University, Milan, Italy.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Tana
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Bianchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Vitali
authors.forename: Flavio
authors.initials: F
authors.lastname: Villani
authors.forename: Sergio
authors.initials: S
authors.lastname: Cerutti
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen