title: Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC.
abstract: The high dose per fraction delivered to lung lesions in stereotactic body radiation therapy (SBRT) demands high dose calculation and delivery accuracy. The inhomogeneous density in the thoracic region along with the small fields used typically in intensity-modulated radiation therapy (IMRT) treatments poses a challenge in the accuracy of dose calculation. In this study we dosimetrically evaluated a pre-release version of a Monte Carlo planning system (PEREGRINE 1.6b, NOMOS Corp., Cranberry Township, PA), which incorporates the modeling of serial tomotherapy IMRT treatments with the binary multileaf intensity modulating collimator (MIMiC). The aim of this study is to show the validation process of PEREGRINE 1.6b since it was used as a benchmark to investigate the accuracy of doses calculated by a finite size pencil beam (FSPB) algorithm for lung lesions treated on the SBRT dose regime via serial tomotherapy in our previous study. Doses calculated by PEREGRINE were compared against measurements in homogeneous and inhomogeneous materials carried out on a Varian 600C with a 6 MV photon beam. Phantom studies simulating various sized lesions were also carried out to explain some of the large dose discrepancies seen in the dose calculations with small lesions. Doses calculated by PEREGRINE agreed to within 2% in water and up to 3% for measurements in an inhomogeneous phantom containing lung, bone and unit density tissue.
authors.affiliation: Cancer Therapy and Research Center, San Antonio, Texas 78229, USA. prassiah@ctrc.net
authors.forename: P
authors.initials: P
authors.lastname: Rassiah-Szegedi
authors.forename: M
authors.initials: M
authors.lastname: Fuss
authors.forename: D
authors.initials: D
authors.lastname: Sheikh-Bagheri
authors.forename: M
authors.initials: M
authors.lastname: Szegedi
authors.forename: S
authors.initials: S
authors.lastname: Stathakis
authors.forename: J
authors.initials: J
authors.lastname: Lancaster
authors.forename: N
authors.initials: N
authors.lastname: Papanikolaou
authors.forename: B
authors.initials: B
authors.lastname: Salter
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008954:Models, Biological; D009010:Monte Carlo Method; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012062:Relative Biological Effectiveness