Evolutionary developmental biology and genomics.
Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.
Cañestro
Cristian
C
Institute of Neuroscience, 1425 East 13th Avenue, University of Oregon, Eugene, Oregon 97403, USA.
Yokoi
Hayato
H
Postlethwait
John H
JH
D000818:Animals; D015509:Developmental Biology; D019143:Evolution, Molecular; D005796:Genes / Q000502:physiology*; D014644:Genetic Variation; D005828:Genetics, Population; D016678:Genome; D023281:Genomics; D006801:Humans; D012641:Selection, Genetic