title: The process of mRNA-tRNA translocation.
abstract: In the elongation cycle of translation, translocation is the process that advances the mRNA-tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during translocation.
authors.affiliation: Howard Hughes Medical Institute and Health Research Incorporated, Wadsworth Center, Empire State Plaza, Albany, NY 12201-0509, USA. joachim@wadsworth.org
authors.forename: Joachim
authors.initials: J
authors.lastname: Frank
authors.forename: Haixiao
authors.initials: H
authors.lastname: Gao
authors.forename: Jayati
authors.initials: J
authors.lastname: Sengupta
authors.forename: Ning
authors.initials: N
authors.lastname: Gao
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Taylor
mesh_terms: D000818:Animals; D001692:Biological Transport; D002384:Catalysis; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008957:Models, Genetic; D020653:Peptide Elongation Factor G / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism
chemical_list: D020653:Peptide Elongation Factor G; D012333:RNA, Messenger; D006160:Guanosine Triphosphate; D012343:RNA, Transfer