Five-year outcome of a primary-care-based inception cohort of patients with inflammatory polyarthritis plus psoriasis.
OBJECTIVE
To establish whether patients with inflammatory arthritis plus psoriasis have a different outcome from those who do not have psoriasis.


METHODS
Seventy-nine patients with inflammatory arthritis plus psoriasis were recruited by the Norfolk Arthritis Register (NOAR) in 1990-94 and followed for 5 yrs. Their outcome was compared with the remainder (n = 755) of the NOAR cohort. We then restricted the analysis to subjects who were rheumatoid factor (RF)-negative, and compared those with and without psoriasis. Outcomes studied included remission, deformed joint count, the presence and extent of erosive damage and physical function.


RESULTS
Patients with psoriasis were younger, more likely to be male, less likely to be RF-positive and more likely to have been treated with disease-modifying drugs than patients without psoriasis. After adjustment for age, gender and treatment, the only differences between the psoriasis and non-psoriasis groups were in RF positivity (adjusted odds ratio 0.44; 95% CI 0.25, 0.78) and in the Larsen score in patients with erosions.


CONCLUSIONS
Patients with inflammatory arthritis plus psoriasis have a similar outcome to other RF-negative patients with arthritis.
Morgan
C
C
ARC Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Lunt
M
M
Bunn
D
D
Scott
D G I
DG
Symmons
D P M
DP
D000328:Adult; D017677:Age Distribution; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011320:Primary Health Care; D011336:Probability; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013997:Time Factors
D018501:Antirheumatic Agents