Influenza virus not cRAFTy enough to dodge viperin.
Interferons elicit antiviral responses by inducing the expression of a large number of host cell genes. In this issue of Cell Host & Microbe, Wang and colleagues report that the interferon-inducible protein viperin inhibits influenza A virus release by impairing the formation of cholesterol-enriched plasma membrane microdomains, or lipid rafts. Viperin appears to disrupt lipid rafts by suppressing the activity of farnesyl diphosphate synthase, a key enzyme in isoprenoid biosynthesis.
Waheed
Abdul A
AA
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.
Freed
Eric O
EO
D000998:Antiviral Agents / Q000494:pharmacology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006801:Humans; D007372:Interferons / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology; D009975:Orthomyxoviridae / Q000187:drug effects*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins / Q000502:physiology*; D014779:Virus Replication; D000090123:Viperin Protein
D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007372:Interferons; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins; C444427:RSAD2 protein, human; D000090123:Viperin Protein