title: Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case.
abstract: Diffuse infiltrative lymphocytosis syndrome (DILS) is an uncommon manifestation of HIV infection characterised by persistent circulating CD8+ lymphocytosis accompanied by visceral lymphocytic infiltration. The lungs and the salivary glands are the most common organs involved. Parotid enlargement in HIV-seropositive subjects may represent HIV-associated lymphoepithelial lesions, hyperplastic lymphadenopathy, lymphoma, bacterial and viral infections, Sjögren's syndrome and DILS. Therefore confirmatory histopathological diagnosis and immunohistochemical analysis following a biopsy is essential to determine the exact nature of the salivary gland enlargement. A review of the literature of DILS and a description of a typical case of bilateral cystic lymphoepithelial lesions of the parotid glands, in an HIV-seropositive subject with DILS, is presented.
authors.affiliation: Department of Periodontology and Oral Medicine, Box D26, Faculty of Dentistry, University of Limpopo, Medunsa Campus 0204, South Africa. lfeller@medunsa.ac.za
authors.forename: L
authors.initials: L
authors.lastname: Feller
authors.forename: J P
authors.initials: JP
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Bouckaert
authors.forename: M N
authors.initials: MN
authors.lastname: Muthuphei
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications; D006801:Humans; D018655:Lymphocyte Count; D008218:Lymphocytosis / Q000209:etiology*; D008297:Male; D010305:Parotid Diseases / Q000209:etiology; D013577:Syndrome