The effect of flavonoid derivatives on doxorubicin transport and metabolism.
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
Václavíková
Radka
R
Group for Biotransformations, Center of Occupational Medicine, National Institute of Public Health, Srobarova 48, 100 42 Prague 10, Czech Republic.
Kondrová
Eliska
E
Ehrlichová
Marie
M
Boumendjel
Ahcene
A
Kovár
Jan
J
Stopka
Pavel
P
Soucek
Pavel
P
Gut
Ivan
I
D000903:Antibiotics, Antineoplastic; D001572:Benzofurans / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000493:pharmacokinetics*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008660:Metabolism / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D001572:Benzofurans; D005419:Flavonoids; C486837:aurone; D004317:Doxorubicin; D011794:Quercetin; C010013:adriamycinol