Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry.
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2'-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2',3'-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.
Pérez-Castro
Isabel
I
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
Caamaño
Olga
O
Fernández
Franco
F
García
Marcos D
MD
López
Carmen
C
De Clercq
Erik
E
D000998:Antiviral Agents / Q000737:chemistry*; D007700:Kinetics; D009705:Nucleosides / Q000138:chemical synthesis*; D012254:Ribavirin / Q000031:analogs & derivatives*; D014230:Triazoles / Q000737:chemistry*
D000998:Antiviral Agents; D009705:Nucleosides; D014230:Triazoles; D012254:Ribavirin