title: Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange.
abstract: Two new GdEGTA (EGTA = ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.
authors.affiliation: Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Via Bellini 25/G, I-15100 Alessandria, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Avedano
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.forename: Alberto
authors.initials: A
authors.lastname: Lombardi
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Giovenzana
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.forename: Dario
authors.initials: D
authors.lastname: Longo
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta