Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature.
BACKGROUND
Inflammatory myofibroblastic tumor (IMT) of the heart is extremely rare with unpredictable clinical expression. IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics malignancy, making a definitive diagnosis difficult, prior to histopathological examination.


RESULTS
We describe a case of an intracardiac IMT in a 69-year-old woman. Histopathological examination of excised specimens revealed a marked, polymorphic, infiltrate of lymphocytes and plasma cells.


CONCLUSIONS
Cardiac IMTs are benign lesions with favorable prognosis. Herein, we present this case, along with a review of all cardiac IMTs published after the last review in 2002, with emphasis on clinical, pathologic, and immunohistochemical features.
Butany
Jagdish
J
Department of Pathology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada. jagdish.butany@uhn.on.ca <jagdish.butany@uhn.on.ca>
Dixit
Vidya
V
Leong
Shaun W
SW
Daniel
Lorretta B
LB
Mezody
Mellita
M
David
Tirone E
TE
D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D006348:Cardiac Surgical Procedures; D003937:Diagnosis, Differential; D004452:Echocardiography; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000473:pathology* / Q000601:surgery; D008214:Lymphocytes / Q000473:pathology; D008943:Mitral Valve / Q000473:pathology*; D047708:Myofibroma / Q000473:pathology* / Q000601:surgery; D010950:Plasma Cells / Q000473:pathology; D016896:Treatment Outcome