title: How viruses avoid stress.
abstract: Cellular responses to counter virus infection lead to the induction of cytoplasmic stress granules, which are composed of translationally stalled mRNAs. In this issue of Cell Host & Microbe, White and colleagues elucidate a mechanism where a poliovirus protease specifically cleaves a host cell factor involved in assembly of stress granules. This strategy ensures viral access to the limiting amounts of translation factors and interferes with host cell mRNA sorting.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Schütz
authors.forename: Peter
authors.initials: P
authors.lastname: Sarnow
mesh_terms: D003594:Cytoplasmic Granules / Q000502:physiology*; D006801:Humans; D014176:Protein Biosynthesis; D034443:RNA Transport; D012333:RNA, Messenger / Q000378:metabolism; D014762:Viral Interference; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology*; D018406:Virus Physiological Phenomena
chemical_list: D012333:RNA, Messenger; D014764:Viral Proteins