title: Systems biology of antibiotic production by microorganisms.
abstract: The synthesis of secondary metabolites by microorganisms, specifically antibiotics, is of great scientific and economic importance. The onset (control and regulation) of secondary metabolite formation has and still is intriguing scientists both in industry and academia. Despite many studies, there is little known about the molecular mechanisms underlying the regulation of secondary metabolism. With the recent developments in genomics and further development of advanced post-genomic techniques, it will be possible to apply a more holistic analysis to the regulation of antibiotic production in microorganisms. Here we review current knowledge about the control and regulation of secondary metabolites, with a focus on antibiotics. We will also review developments in the genomics of antibiotic-producing microorganisms, and discuss the use of systems biology for gaining a better understanding of the networks involved in regulation of antibiotic production.
authors.affiliation: Center for Microbial Biotechnology, BioCentrum-DTU, Building 223, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: J Stefan
authors.initials: JS
authors.lastname: Rokem
authors.forename: Anna Eliasson
authors.initials: AE
authors.lastname: Lantz
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008954:Models, Biological; D049490:Systems Biology
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products