title: [Efficacy of m-FOLFOX6 therapy for colorectal cancer in elderly patients].
abstract: Combination chemotherapy of oxaliplatin, fluorouracil/leucovorin (FOLFOX) has reportedly become a standard regimen for colorectal cancer. In this study, we investigated the efficacies and adverse effects of modified FOLFOX6 (m-FOLFOX6) regimen in elderly patients. Thirty-nine patients with colorectal cancer, who received m-FOLFOX6 in our institution, were studied. Ten of the 39 patients, were older than 70 (elderly patients). Efficacies and adverse effects of m-FOLFOX6 were compared between patients over 70 years of age and those younger than 69 (younger patients). In terms of the response rate, there were no differences between the older and younger elderly patients. Moreover, the grade and frequency of adverse events were similar between them. We concluded that m-FOLFOX6 may bring about the same response rate in older and younger elderly patients. Moreover, m-FOLFOX6 may be given safely regardless of patient age.
authors.affiliation: Dept. of Surgical Oncology, Attached Hospital in Ambulatory Chemotherapy Center, Osaka City University.
authors.forename: Woo
authors.initials: W
authors.lastname: Young Kim
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.forename: Eiji
authors.initials: E
authors.lastname: Noda
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukunaga
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kaizaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Shinto
authors.forename: Koji
authors.initials: K
authors.lastname: Wada
authors.forename: Taeko
authors.initials: T
authors.lastname: Nakano
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil