Developmental biology: micro(RNA)-managing nodal.
Nodal signaling plays an essential role during the induction and patterning of vertebrate embryonic tissue types. In Xenopus and zebrafish, microRNAs regulate Nodal signaling, but surprisingly by very different mechanisms.
Martin
Benjamin L
BL
Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195, USA.
Kimelman
David
D
D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D055457:Nodal Protein; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D035683:MicroRNAs; C526007:NODAL protein, human; D055457:Nodal Protein; D016212:Transforming Growth Factor beta