title: Nanoscale microcavity sensor for single particle detection.
abstract: Recently we demonstrated a biosensor based on a two-dimensional photonic crystal microcavity for detection of proteins. We present a theoretical and experimental study of a modified structure for single particle detection. With an active sensing volume of approximately 0.15 microm(3), the device is capable of detecting approximately 1 fg of matter. Its performance is tested with latex spheres with sizes that fall in the size range of a variety of viruses.
authors.affiliation: The Institute of Optics, University of Rochester, Rochester, New York 14627, USA. mindylee@optics.rochester.edu
authors.forename: Mindy R
authors.initials: MR
authors.lastname: Lee
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Fauchet
mesh_terms: D015374:Biosensing Techniques; D003198:Computer Simulation; D003460:Crystallization; D004581:Electronics; D004867:Equipment Design; D007834:Lasers; D007840:Latex; D008855:Microscopy, Electron, Scanning; D008962:Models, Theoretical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*; D055095:Optics and Photonics; D017785:Photons; D011506:Proteins / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods
chemical_list: D007840:Latex; D011506:Proteins