Synthesis of novel fluorescent nucleoside bearing 3-aminobenzonitrile as a nucleobase.
Fluorescent nucleoside analogue bearing 3-amiobenzonitrile, which was a small and sensitive fluoresces probe to the microenvironment, was synthesized by a palladium-mediated Heck-type coupling reaction from iodated 3-aminobenzonitrile derivative and protected glycal. The spectroscopic study of the nucleoside analogue indicated that the fluorescence quenching caused in water and the fluorescent maximum was strongly dependent on the polarity of solvents.
Ozaki
Hiroaki
H
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan. h-ozaki@chem-bio.gunma-u.ac.jp
Setaka
Takahiro
T
Tsuchiya
Syouta
S
Kawai
Takeshi
T
Kuwahara
Masayasu
M
Sawai
Hiroaki
H
D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
C528349:3-cyano-4-(2'-deoxyribofuranosyl)aniline; D005456:Fluorescent Dyes; D009705:Nucleosides; D012997:Solvents; D014867:Water