Spiroperoxy lactones from furans in one pot: synthesis of (+)-premnalane a.
A [4+2]-cycloaddition between singlet oxygen and a furan, followed by an ene reaction and ketalization, in one synthetic operation, was used for the synthesis of (+)-premnalane A. The first example of a singlet oxygen ene reaction that furnishes exclusively a Z-double bond is noted.
Margaros
Ioannis
I
Department of Chemistry, University of Crete, Vasilika Vouton, 71003 Iraklion, Crete, Greece.
Montagnon
Tamsyn
T
Vassilikogiannakis
Georgios
G