title: [A patient with recurrent rectal cancer in whom pulmonary metastasis disappeared by FOLFOX 4 therapy].
abstract: We performed FOLFOX 4 therapy in a patient with lung metastasis (a 62-year-old woman) after surgery for rectal cancer and observed both normalization of tumor markers and disappearance of the metastasis. Low anterior resection was performed for progressive rectal cancer, and treatment with UFT and folinate was started one month after surgery. However, tumor markers increased after 2 months of treatment and CT scans showed metastases to both lungs. FOLFOX 4 therapy was started, and tumor markers became normal after four courses, while the lung metastases disappeared after 10 courses. The dosage of FOLFOX 4 was reduced after three courses due to neutropenia and diarrhea. This treatment appeared to be effective for the inhibition of lung metastasis associated with colorectal cancer.
authors.affiliation: Dept. of Surgery, Juntendo University Nerima Hospital.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Seigo
authors.initials: S
authors.lastname: Ono
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Shingo
authors.initials: S
authors.lastname: Nitta
authors.forename: Shun
authors.initials: S
authors.lastname: Ishiyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Shinjou
authors.forename: Michio
authors.initials: M
authors.lastname: Machida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kitabatake
authors.forename: Yoshirou
authors.initials: Y
authors.lastname: Ishibiki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Urao
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kojima
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D009944:Organoplatinum Compounds; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin