title: Enhanced in vitro culture of human SAOS-2 osteoblasts on a sand-blasted titanium surface modified with plastic deformation.
abstract: The titanium surfaces with micro-roughness have been studied to substitute machined titanium, with the focus on enhancing the bone apposition onto the implant. In this study we have followed a biomimetic strategy where human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a sandblasted titanium surface modified with plastic deformation. In comparison with sandblasted titanium surface, the plastic deformation increased the cell proliferation and the surface coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
authors.affiliation: University of Pavia, Dipartimento di Informatica e Sistemistica, Centro di Ingegneria Tissutale (C.I.T.), via Ferrata 1, 27100 Pavia, Italy. lorenzo.fassina@unipv.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fassina
authors.forename: Enrica
authors.initials: E
authors.lastname: Saino
authors.forename: Livia
authors.initials: L
authors.lastname: Visai
authors.forename: Maria G
authors.initials: MG
authors.lastname: De Angelis
authors.forename: Francesco
authors.initials: F
authors.lastname: Benazzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Magenes
mesh_terms: D000537:Aluminum Oxide; D001861:Bone Regeneration; D018786:Bone Substitutes; D045744:Cell Line, Tumor; D024042:Collagen Type I / Q000378:metabolism; D004247:DNA / Q000032:analysis; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D024042:Collagen Type I; D004247:DNA; D014025:Titanium; D000537:Aluminum Oxide