title: Base and chain sense in d(CGCGCG)-BP and d(TATATATATATA). Analysis of CD measurements and x-ray crystal data.
abstract: We use CD spectra and x-ray crystal data to compare structures of d(CGCGCG)-BP, which is d(CGCGCG) modified on 2-amino group of guanine by (+)7R,8S-dihydroxy-9S,10R-expoxy-7,8,9,10-tetra hydroBenzo(a)Pyrene (7R-BPDE), with the d(TA)6 dodecamer which with increasing ionic strength of the buffer adopts CD spectrum similar to d(CGCGCG)-BP in 0.1M MgCl2 solution but opposite in sign. We indicates that DNA bases in both oligomers may be in a B-form however as a mirror image of stereo structure of right handed d(CGCGCG)-BP and left handed d(TA)6.
authors.affiliation: University of California Los Angeles, Los Angeles, CA 90095-1570, USA. kazui@mbi.ucla.edu
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Grzeskowiak
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D043542:DNA, Z-Form / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D009994:Osmolar Concentration; D013237:Stereoisomerism
chemical_list: D043542:DNA, Z-Form; D009838:Oligodeoxyribonucleotides; C528370:d(CGCGCG)-BP; C528371:d(TATATATATATA); D004247:DNA