The toll of too much TLR7.
Toll-like receptor 7 (TLR7) detects viral RNA, but can be activated inappropriately by self-RNA, leading to autoimmunity. Deane et al. (2007) show that Tlr7 gene dosage is directly related to the risk of lupus in a mouse model.
Krieg
Arthur M
AM
Coley Pharmaceutical Group, 93 Worcester Street, Suite 101, Wellesley, MA 02481, USA. akrieg@coleypharma.com
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D012313:RNA / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051199:Toll-Like Receptor 7 / Q000276:immunology*
D001324:Autoantigens; D008562:Membrane Glycoproteins; C477038:Tlr7 protein, mouse; D051199:Toll-Like Receptor 7; D012313:RNA