A high-density admixture scan in 1,670 African Americans with hypertension.
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a large-scale admixture scan for genes contributing HTN risk, in which we screened 1,670 African Americans with HTN and 387 control individuals for regions of the genome with elevated proportion of African or European ancestry. No loci were identified that were significantly associated with HTN. We also searched for evidence of an admixture signal at 40 candidate genes and eight previously reported linkage peaks, but none appears to contribute substantially to the differential HTN risk between African and European Americans. Finally, we observed nominal association at one of the loci detected in the admixture scan of Zhu et al. 2005 (p = 0.016 at 6q24.3 correcting for four hypotheses tested), although we caution that the significance is marginal and the estimated odds ratio of 1.19 per African allele is less than what would be expected from the original report; thus, further work is needed to follow up this locus.
Deo
Rahul C
RC
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. rdeo@partners.org
Patterson
Nick
N
Tandon
Arti
A
McDonald
Gavin J
GJ
Haiman
Christopher A
CA
Ardlie
Kristin
K
Henderson
Brian E
BE
Henderson
Sean O
SO
Reich
David
D
D001741:Black or African American / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005789:Genealogy and Heraldry; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male