Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder.
Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for a crucial role of affect regulating brain structures such as the medial frontal cortex in this context. We investigated the cerebral processing of noxious heat stimuli as objective marker for pain sensation in 12 right handed women with somatoform pain disorder fulfilling DSM-IV criteria and 13 age-matched healthy volunteers using functional MRI. The average ratings for experimentally induced pain were not significantly different between controls and patients concerning pain intensity and pain unpleasantness. Comparing patients with controls a pain related hypoactive state of the ventromedial prefrontal/orbitofrontal cortex (BA 10/11) and a hyperactive state of the parahippocampal gyrus, amygdala and anterior insula were found in the patient group. Our findings of an altered cerebral processing of experimentally induced pain in patients with somatoform pain disorder support the hypothesis of dysfunctional pain processing, especially in affect regulating regions.
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Abteilung Psychosomatik und Psychotherapie, Medizinische Hochschule Hannover, Carl-Neuberg - Str. 1, 30625 Hannover, Germany Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Germany Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, Germany Klinik und Poliklinik für Psychosomatische Medizin, Psychotherapie und Med. Psychologie, Klinikum rechts der Isar, Technische Universität München, Germany Abteilung für Neuroradiologie, Institut für Röntgendiagnostik, Klinikum rechts der Isar, Technische Universität München, Germany.
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D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D008032:Limbic System / Q000033:anatomy & histology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology*; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D010812:Physical Stimulation; D017397:Prefrontal Cortex / Q000503:physiopathology; D013001:Somatoform Disorders / Q000503:physiopathology*