Induction of renoprotective gene expression by hypoxia-inducible transcription factor-1alpha ameliorates renal damage.
Hypoxia can cause not only acute kidney injury but also chronic kidney diseases. Hypoxia-inducible transcription factors activated by hypoxia play an important role in the cellular and tissular adaptation to low oxygen conditions. Hypoxia-inducible transcription factor-1 is composed of alpha and beta subunits. Hypoxia-inducible transcription factor-1alpha (HIF-1alpha) is known as a key regulator in protective role of renal damage by induction of downstream protective genes such as erythropoietin, heme oxygenase-1, vascular endothelial growth factor and glucose transporter-1. These proteins coded by protective genes are sufficient to induce renoprotection. So we hypothesize that recombinant adeno-associated viral HIF-1alpha gene will offer potential as a novel means to treat renal disease and can ameliorate renal damage efficiently by the injection of renal vein.
Wang
Weiwei
W
Jinling Hospital, Medical School, Nanjing University, Nanjing 210002, People's Republic of China.
Zhang
Jinyuan
J
D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D051246:Glucose Transport Proteins, Facilitative / Q000096:biosynthesis; D051547:Heme Oxygenase-1 / Q000096:biosynthesis; D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism / Q000502:physiology*; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000378:metabolism*; D008954:Models, Biological; D008962:Models, Theoretical; D010100:Oxygen / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D051246:Glucose Transport Proteins, Facilitative; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D051547:Heme Oxygenase-1; D010100:Oxygen