Stimulation of the nucleus basalis of Meynert produces an increase in the extracellular release of nerve growth factor in the rat cerebral cortex.
Cerebral cortical extracellular NGF was collected and measured every 100 min using microdialysis and ELISA in anesthetized rats. The NGF level, which was stable at rest, increased in the ipsilateral cortex at 200-500 min after the end of focal electrical stimulation to the unilateral NBM for 100 min.
Hotta
Harumi
H
Department of the Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan. hhotta@tmig.or.jp
Uchida
Sae
S
Kagitani
Fusako
F
D000818:Animals; D020532:Basal Nucleus of Meynert / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism*; D004558:Electric Stimulation; D006801:Humans; D008297:Male; D020932:Nerve Growth Factor / Q000032:analysis / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
D020932:Nerve Growth Factor