Diet with LPP for renal patients increases daily energy expenditure and improves motor function in parkinsonian patients with motor fluctuations.
OBJECTIVE
To establish whether a diet based on the usage of low-protein products for renal patients (LPP) is associated with higher energy expenditure (EE) than a free low-protein diet (NO-LPP) by calculating 24 h EE by indirect calorimetry using an electronic armband monitor.


METHODS
Randomized, cross-over, single-blind, pilot clinical trial performed comparing two different low-protein dietary regimens.


METHODS
Forty-two days with LPP and 42 days with NO-LPP regimen in six patients with Parkinson's disease with levodopa.


METHODS
Monitoring patient response to two different nutritional schemes through indirect calorimetry (armband), BMI, Patient Global Improvement Scale.


RESULTS
Mean total EE was 1731 +/- 265 kcal/day with NO-LPP vs. 1903 +/- 265 kcal/day with LPP (p = 0.02).


CONCLUSIONS
The usage of LPP increases EE and improves motor function in PD patients to a greater extent than NO-LPP dietary regimen. Calorie intake should be increased to prevent malnutrition in the long-term.
Barichella
Michela
M
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. barichella@parkinson.it
Savardi
Chiara
C
Mauri
Andrea
A
Marczewska
Agnieszka
A
Vairo
Antonella
A
Baldo
Cinzia
C
Massarotto
Arianna
A
Cordara
Sara Elisabetta
SE
Pezzoli
Gianni
G
D017668:Age of Onset; D000368:Aged; D002151:Calorimetry; D018592:Cross-Over Studies; D018753:Diet, Protein-Restricted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000178:diet therapy* / Q000503:physiopathology*; D010865:Pilot Projects; D051437:Renal Insufficiency / Q000178:diet therapy* / Q000503:physiopathology; D016037:Single-Blind Method