Intracellular machinery for the transport of AMPA receptors.
AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.
Esteban
J A
JA
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA. estebanj@umich.edu
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D013379:Substrate Specificity; D013569:Synapses / Q000502:physiology*
D018091:Receptors, AMPA