Obesity: a risk factor for preeclampsia.
Obesity is becoming an epidemic worldwide. Among young women, obesity is especially important because maternal obesity confers an increased risk of preeclampsia, a hypertensive disorder of pregnancy and a leading cause of maternal and fetal morbidity and mortality. It is not known why obesity is a risk factor for preeclampsia, but these conditions might be related through common features related to oxidative stress, inflammation and altered vascular function. Recently, extensive vascular infiltration of neutrophils and vascular inflammation has been reported in both preeclamptic women and obese women. Therefore, if the vasculature of obese women is inflamed, they could be at increased risk of developing preeclampsia when they become pregnant and are exposed to the additional burdens of pregnancy.
Walsh
Scott W
SW
Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0034, USA. swwalsh@vcu.edu
D005260:Female; D006801:Humans; D007249:Inflammation; D009504:Neutrophils; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications; D014657:Vasculitis