A UK clinical isolate of Bordetella hinzii from a patient with myelodysplastic syndrome.
What is believed to be the first clinical isolate of Bordetella hinzii in the UK, from a patient with myelodysplastic syndrome, is described. This patient had no known avian exposure, and the source of the organism remains unknown. It appears that the underlying immune deficiency of the patient increased the susceptibility to opportunistic infection with this organism. Human infection with B. hinzii is rare and this species is difficult to differentiate from Bordetella avium by routine phenotypic methods. Confirmation can be reliably achieved using genotypic methods, and the greater mutational variation of the ompA gene compared to other genes (e.g. 16S rRNA gene) allows unambiguous identification of this and other non-classical Bordetella species.
Fry
Norman K
NK
Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
Duncan
John
J
Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
Edwards
Martin T
MT
Statistics, Modelling and Bioinformatics Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.|Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
Tilley
Rebecca E
RE
West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK.
Chitnavis
Dipti
D
West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK.
Harman
Ruth
R
West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK.
Hammerton
Haydn
H
West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK.
Dainton
Linda
L
West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK.
D000368:Aged; D001884:Bordetella / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D001885:Bordetella Infections / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000382:microbiology*; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S; D006113:United Kingdom
D012336:RNA, Ribosomal, 16S