title: Synthesis of novel fluorescent nucleoside bearing 3-aminobenzonitrile as a nucleobase.
abstract: Fluorescent nucleoside analogue bearing 3-amiobenzonitrile, which was a small and sensitive fluoresces probe to the microenvironment, was synthesized by a palladium-mediated Heck-type coupling reaction from iodated 3-aminobenzonitrile derivative and protected glycal. The spectroscopic study of the nucleoside analogue indicated that the fluorescence quenching caused in water and the fluorescent maximum was strongly dependent on the polarity of solvents.
authors.affiliation: Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan. h-ozaki@chem-bio.gunma-u.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ozaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Setaka
authors.forename: Syouta
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawai
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sawai
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: C528349:3-cyano-4-(2'-deoxyribofuranosyl)aniline; D005456:Fluorescent Dyes; D009705:Nucleosides; D012997:Solvents; D014867:Water