title: Synthesis and evaluation of 2-pyrrolepolyamide-2'-deoxyguanosine 5'-phosphate.
abstract: 2-Pyrrolepolyamide-2'-deoxyguanosine 5'-phosphate (hybrid 4) was synthesized and evaluated in terms of the inhibition of mouse mammary carcinoma FM3A cell growth. Hybrid 4 exhibited the highest activity compared with the other hybrids (1, 2, and 3) and distamycin A.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji,Tokyo 192-0392, Japan. kawasima@ps.toyaku.ac.jp
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kawashima
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Terui
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tomitori
authors.forename: Keiko
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohba
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: C528369:2-pyrrolepolyamide-2'-deoxyguaonsine 5'-phosphate; D000970:Antineoplastic Agents; D011758:Pyrroles; D006157:Guanosine Monophosphate