UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
BACKGROUND
We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC).


METHODS
The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were men younger than 75 years. HCC and cirrhosis patients were stratified according to time since cirrhosis diagnosis.


RESULTS
We found a positive association between the UGT1A7*3/*3 genotype and HCC when the comparison was restricted to patients whose disease was of viral origin [OR = 3.4 (0.3-45)] but a negative association when it included only alcoholic patients [OR = 0.1 (0.02-0.6), p = 0.01].


CONCLUSIONS
Our study shows that UGT1A7 may play a role in hepatocellular carcinogenesis and that this role may differ according to the primary cause of the cirrhosis.
Stücker
I
I
Inserm, U754, Villejuif, F-94807 France. stucker@vjf.inserm.fr
Loriot
M A
MA
N'koutchou
G
G
Cénée
S
S
Bodin
L
L
Mulot
C
C
Gelu-Simeon
M
M
Pelletier
L
L
Bronowicki
J P
JP
Degos
F
F
Beaune
P
P
Laurent-Puig
P
P
Hémon
D
D
Trinchet
J C
JC
Pelletier
G
G
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D014453:Glucuronosyltransferase / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications / Q000201:enzymology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006526:Hepatitis C / Q000150:complications / Q000201:enzymology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000201:enzymology; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012698:Serologic Tests
D015415:Biomarkers; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D014453:Glucuronosyltransferase