title: Pancreatic duct stent placement prevents post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction but normal manometry results.
abstract: BACKGROUND
  Placement of a pancreatic duct (PD) stent reduces post-ERCP pancreatitis rates in high-risk patients. Patients with suspected sphincter of Oddi dysfunction (SOD) who are found to have normal manometry results (SOM) are also at high risk for this complication.
  
  
  OBJECTIVE
  Our purpose was to determine whether PD stent placement reduces pancreatitis rates in this patient population.
  
  
  METHODS
  Non-randomized, retrospective study.
  
  
  METHODS
  Large, tertiary referral center.
  
  
  METHODS
  From January 1999 to December 2005, patients who underwent ERCP with normal SOM were identified from our ERCP database. Incidence of patient/procedure risk factors for post-ERCP pancreatitis, trainee participation, and prior sphincter therapy were evaluated.
  
  
  METHODS
  PD stent placement.
  
  
  METHODS
  Pancreatitis rates.
  
  
  RESULTS
  A total of 403 patients were available for analysis: 169 had a PD stent placed (group 1) and 234 did not (group 2). Overall, pancreatitis rates were 2.4% in group 1 and 9.0% in group 2 (P= .006, odds ratio 4.1, 95% CI 1.4-12.0). Other than increased PD opacification in group 1 (P< .001), the incidence of risk factors for pancreatitis, trainee participation, or prior sphincter therapy was similar between the 2 groups. In patients with an intact papilla, stent placement reduced the rate of pancreatitis from 11.5% to 2.7% (P= .012). In patients with prior sphincter therapy, no benefit was seen from stent placement, although there was a trend to decreased pancreatitis rates in stented patients with prior pancreatobiliary sphincterotomy.
  
  
  CONCLUSIONS
  Nonrandomized, retrospective design.
  
  
  CONCLUSIONS
  Temporary PD stent placement reduces pancreatitis rates in patients with suspected SOD but normal SOM and an intact papilla. Their routine use is recommended when evaluating this difficult, high-risk patient population.
authors.affiliation: Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202, USA.
authors.forename: Abdo M
authors.initials: AM
authors.lastname: Saad
authors.forename: Evan L
authors.initials: EL
authors.lastname: Fogel
authors.forename: Lee
authors.initials: L
authors.lastname: McHenry
authors.forename: James L
authors.initials: JL
authors.lastname: Watkins
authors.forename: Stuart
authors.initials: S
authors.lastname: Sherman
authors.forename: Laura
authors.initials: L
authors.lastname: Lazzell-Pannell
authors.forename: Glen A
authors.initials: GA
authors.lastname: Lehman
mesh_terms: D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008365:Manometry; D010183:Pancreatic Ducts; D010195:Pancreatitis / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D046628:Sphincter of Oddi Dysfunction / Q000150:complications*; D015607:Stents; D013997:Time Factors