Pre-operative redox state affects 1-month survival in patients with advanced heart failure undergoing left ventricular assist device implantation.
BACKGROUND
Left ventricular assist device (LVAD) implantation has proven effective as a bridge to transplantation in end-stage heart failure patients (ESHFPs), although survival during device support is critical. Oxidative stress has been implicated in the development of heart failure, but the influence of redox state on in-hospital post-LVAD outcome has not been clarified.


RESULTS
In this report we describe the oxidant/anti-oxidant profiles of 15 ESHFPs before LVAD placement, 5 of whom did not survive to 1 month, and in 30 subjects without cardiac disease, representing the control group.


CONCLUSIONS
Preliminary findings suggest that adequate activity of the GPx-1-based anti-oxidant system before device placement is associated with patient survival up to 1 month, despite comparable baseline oxidative stress in patients who both survived and died (within 2 weeks post-LVAD).
Caruso
Raffaele
R
CNR Clinical Physiology Institute of Milan, Milan, Italy.
Garatti
Andrea
A
Sedda
Valentina
V
Milazzo
Filippo
F
Campolo
Jonica
J
Colombo
Tiziano
T
Catena
Emanuele
E
Cighetti
Giuliana
G
Russo
Claudio
C
Frigerio
Maria
M
Vitali
Ettore
E
Parodi
Oberdan
O
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006333:Heart Failure / Q000378:metabolism* / Q000628:therapy*; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D011237:Predictive Value of Tests; D016019:Survival Analysis; D016896:Treatment Outcome; D000094765:Glutathione Peroxidase GPX1
D015415:Biomarkers; D008315:Malondialdehyde; C486484:GPX3 protein, human; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human