Maternal ulcerative colitis and fetal brain injury: long-term neurologic outcome.
Two maternal-fetal case presentations illustrate the possible association of active maternal ulcerative colitis during pregnancy and fetal brain injury resulting in long-term neurological sequelae. Thromboembolic complications may occur in the fetus based on similar mechanisms for stroke in children and adults with active inflammatory bowel disease. Identification of thrombophilia in the pregnant woman with active ulcerative colitis may better explain a pathophysiologic mechanism for long-term neurological morbidity in offspring.
Scher
Mark S
MS
Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA. Mark.Scher@UHhospitals.org
D001930:Brain Injuries / Q000209:etiology*; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications