Synthesis and evaluation of novel heterocyclic MMP inhibitors.
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
Hayashi
Ryuji
R
Center for Protease Research, Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA.
Jin
Xiaomin
X
Cook
Gregory R
GR
D020134:Catalytic Domain / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D061965:Matrix Metalloproteinase Inhibitors; D011728:Pyridones; D014230:Triazoles; D020782:Matrix Metalloproteinases