title: Vicilin allergens of peanut and tree nuts (walnut, hazelnut and cashew nut) share structurally related IgE-binding epitopes.
abstract: Surface-exposed IgE-binding epitopes of close overall conformation were characterized on the molecular surface of three-dimensional models built for the vicilin allergens of peanut (Ara h 1), walnut (Jug r 2), hazelnut (Cor a 11) and cashew nut (Ana o 1). They correspond to linear stretches of conserved amino acid sequences mainly located along the C-terminus of the polypeptide chains. A glyco-epitope corresponding to an exposed N-glycosylation site could also interfere with the IgE-binding epitopes. All these epitopic regions should participate in the IgE-binding cross-reactivity commonly reported between tree nuts or between peanut and some tree nuts in sensitized individuals. Owing to this epitopic community which constitutes a risk of cross-sensitization, the avoidance or a restricted consumption of other tree nuts should be recommended to peanut-sensitized individuals.
authors.affiliation: Surfaces Cellulaires et Signalisation chez les Végétaux, UMR-CNRS 5546, Pôle de Biotechnologie végétale, 24 Chemin de Borde Rouge, 31326 Castanet-Tolosan, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Barre
authors.forename: Camille
authors.initials: C
authors.lastname: Sordet
authors.forename: Raphaël
authors.initials: R
authors.lastname: Culerrier
authors.forename: Fabienne
authors.initials: F
authors.lastname: Rancé
authors.forename: Alain
authors.initials: A
authors.lastname: Didier
authors.forename: Pierre
authors.initials: P
authors.lastname: Rougé
mesh_terms: D031021:Anacardium / Q000276:immunology; D010367:Arachis; D001665:Binding Sites; D017124:Conserved Sequence; D031211:Corylus / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D000939:Epitopes / Q000378:metabolism; D006967:Hypersensitivity; D007073:Immunoglobulin E / Q000378:metabolism; D031324:Juglans / Q000276:immunology; D019684:Magnoliopsida / Q000276:immunology*; D009754:Nuts / Q000276:immunology*; D010940:Plant Proteins / Q000276:immunology*; D055314:Seed Storage Proteins
chemical_list: D000939:Epitopes; D010940:Plant Proteins; D055314:Seed Storage Proteins; D007073:Immunoglobulin E; C015575:vicilin protein, plant