title: Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry.
abstract: The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2'-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2',3'-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Pérez-Castro
authors.forename: Olga
authors.initials: O
authors.lastname: Caamaño
authors.forename: Franco
authors.initials: F
authors.lastname: Fernández
authors.forename: Marcos D
authors.initials: MD
authors.lastname: García
authors.forename: Carmen
authors.initials: C
authors.lastname: López
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry*; D007700:Kinetics; D009705:Nucleosides / Q000138:chemical synthesis*; D012254:Ribavirin / Q000031:analogs & derivatives*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D014230:Triazoles; D012254:Ribavirin