Effect of pravastatin on phenotypical transformation of fibroblasts and hypertrophy of cardiomyocytes in culture.
We studied the effects of pravastatin on the functional state of cardiomyocytes and cardiac fibroblasts in culture. Pravastatin in doses of 0.1-10.0 microM suppressed proliferation of cardiac fibroblasts and their phenotypical transformation into myofibroblasts and prevented the development of cardiomyocyte hypertrophy. Pleiotropic effects of pravastatin can be explained by inhibition of production transforming growth factor beta1 production.
Moiseeva
O M
OM
V. A. Almazov Institute of Cardiology, Russian Ministry of Health, St Peterburg. omoiseeva@front.ru
Semyonova
E G
EG
Polevaya
E V
EV
Pinayev
G P
GP
D000818:Animals; D049108:Cell Enlargement; D049109:Cell Proliferation; D002478:Cells, Cultured; D053938:DNA Fragmentation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects*; D017035:Pravastatin / Q000494:pharmacology*; D051381:Rats; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D053773:Transforming Growth Factor beta1; D017035:Pravastatin