title: Dimercaptosuccinic acid (DMSA) renal scan in the evaluation of hypertension in children.
abstract: Renal scarring is known to be associated with hypertension. The primary objective of this study was to investigate the prevalence of renal scarring in children referred to our clinic with hypertension. The secondary objective was to compare renal ultrasound (US) examination with dimercaptosuccinic acid (DMSA) renal scan in diagnosing renal scars in these patients. The study included 159 patients who underwent DMSA renal scan as well as renal US for the evaluation of hypertension of unknown etiology. Thirty-three (21%) patients were found to have renal scars; their demographic details, including mean age and gender distribution, were not significantly different from those without renal scars. In comparison with the DMSA renal scan, sensitivity and specificity of renal US in diagnosing renal scars were 36% and 94%, respectively. In our study, in which the prevalence of scarring was 21%, this gave positive predictive and negative predictive values of 63% and 85%, respectively. In conclusion, our study indicates that renal scarring is present in 21% of otherwise healthy children who are evaluated for newly diagnosed hypertension, and renal US is not a sensitive imaging modality to rule out renal scarring.
authors.affiliation: Pediatric Nephrology and Hypertension, Children's Hospital of Michigan, Detroit, MI, USA.
authors.forename: Maheen
authors.initials: M
authors.lastname: Ahmed
authors.forename: Daniel
authors.initials: D
authors.lastname: Eggleston
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kapur
authors.forename: Amrish
authors.initials: A
authors.lastname: Jain
authors.forename: Rudolph P
authors.initials: RP
authors.lastname: Valentini
authors.forename: Tej K
authors.initials: TK
authors.lastname: Mattoo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000209:etiology*; D007223:Infant; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid