title: 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.
abstract: Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
authors.affiliation: Dipartimento di Studi di chimica e tecnologia delle sostanze biologicamente attive, Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Roma, Italia. luigi.scipione@uniroma1.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Scipione
authors.forename: Daniela
authors.initials: D
authors.lastname: De Vita
authors.forename: Alessandra
authors.initials: A
authors.lastname: Musella
authors.forename: Lisa
authors.initials: L
authors.lastname: Flammini
authors.forename: Simona
authors.initials: S
authors.lastname: Bertoni
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Barocelli
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D015761:4-Aminopyridine; D012601:Scopolamine