[Pathophysiology of wound healing and current treatment strategies in a urological context].
Acute wound healing is a dynamic, interactive process culminating in the closure of a tissue defect. Chronic wounds result when the healing cascade is impaired. Proteases destroy important growth factors and matrix proteins, inflammation is prolonged, and the normal healing process does not take place within the expected time span. Owing to demographic changes the investigation of age-related pathologies, including treatment-resistant wounds, has become increasingly important. The TIME concept (tissue, infection, moisture imbalance, edge of wound) assesses essential elements in the healing process that can be addressed in the treatment of chronic wounds. Moist wound treatment is standard therapy. Definitive research trials on the level of success that can be achieved with different dressings are still needed. New types of treatment should be selected with due consideration for clinical variables, the patient's quality of life and independence, and cost effectiveness.
Wicke
C
C
Klinik für Allgemeine, Viszeral- und Transplantationschirurgie, Universitätsklinikum Tübingen, Hoppe-Seyler-Strasse 3, Tübingen, Germany. corinna.wicke@med.uni-tuebingen.de
Schilling
D
D
Feyerabend
S
S
Königsrainer
A
A
Stenzl
A
A
D001458:Bandages; D002908:Chronic Disease; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D012307:Risk Factors; D013529:Surgical Wound Dehiscence / Q000503:physiopathology / Q000628:therapy; D013530:Surgical Wound Infection / Q000503:physiopathology / Q000628:therapy*; D014548:Urinary Fistula / Q000503:physiopathology / Q000628:therapy; D014570:Urologic Diseases / Q000601:surgery*; D014571:Urologic Neoplasms / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology*
D011505:Protein-Tyrosine Kinases