Keratin and filaggrin expression in keratoacanthoma.
To clarify the histogenesis of keratoacanthoma, we studied keratin (K) expression in keratoacanthoma (KA) using 10 different anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18 and K19 and anti-filaggrin (filament aggregating protein) antibody. In the centre of KA, K1 and K10 expressions were declined, and K14 and K16 were detected in the tumour cells, suggesting differentiation towards the outer root sheath beneath the orifice of the sebaceous duct. These results suggest that KA differentiates towards the outer root sheath beneath the opening of the sebaceous duct.
Ito
Yoshiyuki
Y
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
Kurokawa
Ichiro
I
Nishimura
Keisuke
K
Hakamada
Arata
A
Isoda
Ken-ichi
K
Yamanaka
Kei-ichi
K
Tsubura
Airo
A
Mizutani
Hitoshi
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D000091344:Filaggrin Proteins; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D053556:Keratin-1 / Q000378:metabolism; D053550:Keratin-10 / Q000378:metabolism; D053547:Keratin-14 / Q000378:metabolism; D053536:Keratin-16 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism*; D007636:Keratoacanthoma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012626:Sebaceous Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012627:Sebaceous Glands / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000473:pathology
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D053556:Keratin-1; D053547:Keratin-14; D053536:Keratin-16; D053550:Keratin-10; D007633:Keratins