title: [Efficacy of S-1 combined with weekly Paclitaxel for gastric cancer with cancerous ascites].
abstract: We used combination therapy of S-1 and Paclitaxel to treat gastric cancer complicated by carcinomatous ascites and assessed the clinical results. The subjects were 8 patients who were gastric-cancer-ascites-positive, and they were treated by biweekly administration of S-1 orally, continuously for 2 weeks, and Paclitaxel on day 1 and day 8 of S-1 administration. The results showed disappearance of the ascites on diagnostic images in 37.5% (3/8) and PR in 50% (4/8) in terms of the main gastric cancer focus. An average 15 courses were conducted, and the overall adverse event rate was 87.5% (7/8). Hematologic toxicity occurred in 75.0% (6/8), and it was G3 or 4 in 37.5% (3/8). Non-hematological toxicity was confirmed in 75.0% (6/8), but none of it was G3 or 4. Although they were historical controls, we assessed the results of treatment in a conventional treatment group (control group; n=24) and the S-1 and Paclitaxel group (S-1+Paclitaxel group; n=8) by comparing the survival rates. MST in the S-1 and Paclitaxel group was 413 days, and the longest survival time was 1,148 days. The 1-year survival rate was 62.5%, and the 2-year survival rate was 37.5%. The survival rate in the S-1+Paclitaxel group was better than in the control group (p<0.001). We have reported this study because S-1+Paclitaxel therapy appears to be an important method of treating gastric cancer complicated by carcinomatous ascites.
authors.affiliation: Dept. of Gastrointestinal and General Surgery, Saiseikai Suita Hospital.
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Soichiro
authors.initials: S
authors.lastname: Tsunemi
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Izumi
authors.forename: Shinji
authors.initials: S
authors.lastname: Iwamoto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001201:Ascites / Q000150:complications* / Q000188:drug therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel