title: Correlating enzyme activity and cellular behavior.
abstract: A photoactivatable phosphorylation sensor used in conjunction with isoform specific inhibitors of protein kinase C enables the enzyme's activity to be monitored inside cells at specific time points during mitosis. PKCbeta was found to be active before, but not after, nuclear envelope breakdown.
authors.affiliation: Department of Chemistry, University of Georgia, Athens, GA 30602-2556, USA. tdore@chem.uga.edu
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Dore
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D011493:Protein Kinase C