Multivalent catalysts for the cleavage of nucleic acids and their models.
Multivalent systems, i.e. systems presenting a discrete collection of several functional groups, are well recognized for their ability to increase binding constants. Less explored is their use as catalysts. We present a number of multivalent nanostructures based on self-assembled gold nanoparticles and dendrimers, which are particularly efficient in the cleavage of nucleic acids and their models.
Manea
Flavio
F
University of Padova, Department of Chemical Sciences, 35131-Padova, Italy.
Pasquato
Lucia
L
Prins
Leonard J
LJ
Scrimin
Paolo
P
D002384:Catalysis; D050091:Dendrimers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008956:Models, Chemical; D009708:Nucleotidases / Q000737:chemistry; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry*
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D050091:Dendrimers; D010755:Organophosphates; D009943:Organophosphorus Compounds; D006046:Gold; D012260:Ribonucleases; D009708:Nucleotidases