title: Angiogenesis and obesity.
abstract: Development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis, and extracellular matrix remodelling. These processes require proteolytic activity, provided mainly by the fibrinolytic (plasminogen/plasmin), matrix metalloproteinase, and ADAM/ADAMTS systems. In early-stage development of adipose tissue, adipogenesis is tightly associated with angiogenesis. Thus, adipose tissue explants trigger blood vessel formation, and in turn adipose tissue endothelial cells promote pre-adipocyte differentiation. Modulation of angiogenesis and of proteolytic systems may have the potential to impair adipose tissue development.
authors.affiliation: Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium. roger.lijnen@med.kuleuven.be
authors.forename: H Roger
authors.initials: HR
authors.lastname: Lijnen
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D019440:Anti-Obesity Agents; D011480:Protease Inhibitors; D010447:Peptide Hydrolases