title: Benign reactive lymphoid hyperplasia of the caruncle and plica: report of 5 cases.
abstract: OBJECTIVE
  To report the clinicopathologic features and management of patients with benign reactive lymphoid hyperplasia of the caruncle and plica semilunaris.
  
  
  METHODS
  This retrospective case series includes 5 patients with lesions in the caruncle or plica semilunaris who underwent surgical excision over a 10-year period. The clinicopathologic features and immunohistochemical studies are reported.
  
  
  RESULTS
  All patients presented with salmon-colored, fish-flesh appearance (3 at the caruncle and 2 in the plica semilunaris). All tumors underwent complete surgical excision. Pathology and immunohistochemical studies showed polyclonal infiltration of lymphoid cells. There was no systemic involvement at presentation or during follow-up (mean, 48 months), and no local recurrence.
  
  
  CONCLUSIONS
  Benign reactive lymphoid hyperplasia should be considered in the differential diagnosis of mass lesions of the caruncle and plica semilunaris, especially in young male patients. Histopathologic evaluation and immunohistochemistry studies are necessary to exclude lymphoma and other malignant lesions. Complete surgical excision of the plica or caruncle does not seem to induce significant complications.
authors.affiliation: Department of Ophthalmology and Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran. abbasbagheri@yahoo.com
authors.forename: Abbas
authors.initials: A
authors.lastname: Bagheri
authors.forename: Babak
authors.initials: B
authors.lastname: Babsharif
authors.forename: Shahin
authors.initials: S
authors.lastname: Yazdani
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Rezaee Kanavi
mesh_terms: D000293:Adolescent; D002648:Child; D003229:Conjunctival Diseases / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D019310:Pseudolymphoma / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies