title: Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments.
abstract: To address the specific challenges of cancer therapy and diagnosis, a number of approaches have been advocated for the development of tumor-targeting antitumor drugs/prodrugs and non-invasive tumor molecular imaging probes. These intelligent drugs and probes are constructed from multi-functional molecular systems. This review focuses on the molecular design of drugs and imaging probes that target tumor-specific microenvironments such as angiogenesis and hypoxia.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tanabe
authors.forename: Zhouen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatta
authors.forename: Sei-ichi
authors.initials: S
authors.lastname: Nishimoto
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects; D015195:Drug Design; D015335:Molecular Probes; D009369:Neoplasms / Q000098:blood supply; D011355:Prodrugs / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D015335:Molecular Probes; D011355:Prodrugs