title: Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial.
abstract: The aim of the study was to compare the effect of the administration of a mixture of fibres on body weight-loss, satiety, lipid profile and glucose metabolism. We included 200 overweight or obese patients in a parallel, double-blind, placebo-controlled clinical trial, who were randomised to receive, in the context of an energy-restricted diet for a period of 16 weeks, a mixed fibre dose (3 g Plantago ovata husk and 1 g glucomannan) twice (b.i.d. group) or three times daily (t.i.d. group) or placebo. Weight change was the primary efficacy endpoint. Satiety, dietary compliance, lipid profile, glucose tolerance, insulin resistance and high-sensitivity C-reactive protein were secondary endpoints. Weight loss tended to be higher after both doses of fibre (-4.52 (SD 0.56) and -4.60 (SD 0.55) kg) than placebo (-0.79 (SD 0.58) kg); the differences in changes between groups were not statistically significant. Postprandial satiety increased in both fibre groups compared to the placebo. The differences between groups in LDL-cholesterol levels were significant (P = 0.03), with greater reductions in the two fibre-supplemented groups (-0.38 (SD 0.10) and -0.24 (SD 0.09) mmol/l in the b.i.d. and t.i.d. groups v. -0.06 (SD 0.09) mmol/l in placebo group). A similar pattern was observed for changes in total cholesterol:HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratios. Interventions were well tolerated and had no effects on HDL-cholesterol, glucose and insulin concentrations, glucose tolerance or high-sensitivity C-reactive protein. In conclusion, a 16-week dietary supplement of soluble fibre in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some CVD risk factors, the most important of which was a significant decrease in plasma LDL-cholesterol concentrations.
authors.affiliation: Human Nutrition Unit, Facultat de Medicina i Ciències de la Salut, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain. jordi.salas@urv.cat
authors.forename: Jordi
authors.initials: J
authors.lastname: Salas-Salvadó
authors.forename: Xavier
authors.initials: X
authors.lastname: Farrés
authors.forename: Xavier
authors.initials: X
authors.lastname: Luque
authors.forename: Silvia
authors.initials: S
authors.lastname: Narejos
authors.forename: Manel
authors.initials: M
authors.lastname: Borrell
authors.forename: Josep
authors.initials: J
authors.lastname: Basora
authors.forename: Anna
authors.initials: A
authors.lastname: Anguera
authors.forename: Ferran
authors.initials: F
authors.lastname: Torres
authors.forename: Mònica
authors.initials: M
authors.lastname: Bulló
authors.forename: Rafel
authors.initials: R
authors.lastname: Balanza
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D004043:Dietary Fiber / Q000008:administration & dosage*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008351:Mannans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D050177:Overweight / Q000097:blood / Q000178:diet therapy; D010943:Plantago; D012527:Satiation
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D007328:Insulin; D008351:Mannans; C022901:(1-6)-alpha-glucomannan; D002097:C-Reactive Protein