title: Local control and distant metastasis after electrochemotherapy of a canine anal melanoma.
abstract: Canine anal melanoma is an aggressive neoplasm that rapidly leads to constipation in dogs, thus mimicking the behavior of their human counterpart. In this paper, the successful local palliation of this neoplasm is described using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction with restoration of normal defecation for three months, then experienced massive dissemination to the sublumbar lymph nodes that led to intestinal obstruction and euthanasia. Electrochemotherapy (ECT) is a safe palliative therapy for such neoplasm and warrants further investigations in dogs as well humans.
authors.affiliation: Centre of Biomedical Engineering Ivan Daskalov, Sofia, Bulgaria. info@enricospugnini.net
authors.forename: Enrico P
authors.initials: EP
authors.lastname: Spugnini
authors.forename: Marino
authors.initials: M
authors.lastname: Filipponi
authors.forename: Luca
authors.initials: L
authors.lastname: Romani
authors.forename: Ivan
authors.initials: I
authors.lastname: Dotsinsky
authors.forename: Nikolay
authors.initials: N
authors.lastname: Mudrov
authors.forename: Adone
authors.initials: A
authors.lastname: Baroni
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ruocco
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Laieta
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Montesarchio
authors.forename: Roberto
authors.initials: R
authors.lastname: Cassandro
authors.forename: Gennaro
authors.initials: G
authors.lastname: Citro
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000818:Animals; D001005:Anus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D053672:Electrochemotherapy; D005260:Female; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology