title: Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines.
abstract: We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).
authors.forename: Rafael Henriques
authors.initials: RH
authors.lastname: Jácomo
authors.forename: Raul Antonio Morais
authors.initials: RA
authors.lastname: Melo
authors.forename: Fernanda Ribeiro
authors.initials: FR
authors.lastname: Souto
authors.forename: Ederson Roberto
authors.initials: ER
authors.lastname: de Mattos
authors.forename: Claudia Teresa
authors.initials: CT
authors.lastname: de Oliveira
authors.forename: Evandro M
authors.initials: EM
authors.lastname: Fagundes
authors.forename: Henrique Neves da Silva
authors.initials: HN
authors.lastname: Bittencourt
authors.forename: Rosane Isabel
authors.initials: RI
authors.lastname: Bittencourt
authors.forename: Teresa Cristina
authors.initials: TC
authors.lastname: Bortolheiro
authors.forename: Eduardo J A
authors.initials: EJ
authors.lastname: Paton
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bendlin
authors.forename: Sebastião
authors.initials: S
authors.lastname: Ismael
authors.forename: Maria de Lourdes
authors.initials: Mde L
authors.lastname: Chauffaille
authors.forename: Dirceu
authors.initials: D
authors.lastname: Silva
authors.forename: Katia Borgia B
authors.initials: KB
authors.lastname: Pagnano
authors.forename: Raul
authors.initials: R
authors.lastname: Ribeiro
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Rego
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D018943:Anthracyclines; D014212:Tretinoin