Objective versus subjective assessment of methylphenidate response.
Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 +/- 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.
Manor
Iris
I
ADHD Unit, Geha Mental Health Center, P.O. Box 102, Petach Tikva, 49100, Israel. imanor@clalit.org.il
Meidad
Sheera
S
Zalsman
Gil
G
Zemishlany
Zvi
Z
Tyano
Sam
S
Weizman
Abraham
A
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D012649:Self Concept; D012720:Severity of Illness Index
D000697:Central Nervous System Stimulants; D008774:Methylphenidate