Insulin treatment reduces pre-prandial plasma ghrelin concentrations in children with type 1 diabetes.
BACKGROUND
Ghrelin is well recognized as a key factor in regulating appetite and energy homeostasis. The aim of the present study is to characterize the plasma ghrelin concentrations in children with type 1 diabetes at the time of diagnosis and to determine the effect of metabolic control after insulin therapy on circulating ghrelin levels. Also, the relationship between the simultaneous blood glucose concentrations and fasting plasma ghrelin concentrations was explored.


METHODS
This prospective study assessed the changes in pre-prandial plasma ghrelin levels after treatment of type 1 diabetes with insulin.


RESULTS
The study comprised 19 children with new onset diabetes mellitus. Mean plasma ghrelin levels declined by 29% in diabetic children post insulin treatment (p=0.007). There was a significant correlation between plasma ghrelin and body mass index (BMI) in children with type 1 diabetes at diagnosis (r=-0.54), but not at follow up. The difference in ghrelin at diagnosis and at 3 month follow up demonstrated an inverse relationship to difference in plasma glucose (r=-0.48).


CONCLUSIONS
Plasma ghrelin concentrations could be suppressed in untreated type 1 diabetic children by improved glycemic control following insulin replacement.
Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, The Children's Hospital, University of Alabama at Birmingham, Birmingham, AL 35233, USA. AAshraf@peds.uab.edu
Ambika
A
Ashraf
Gail
G
Mick
Sreelatha
S
Meleth
Xudong
X
Wang
Kenneth
K
McCormick
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male
D001786:Blood Glucose; D054439:Ghrelin; D007004:Hypoglycemic Agents; D007328:Insulin