tRNA traffic meets a cell-cycle checkpoint.
The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain largely unresolved. Findings by Ghavidel et al. (2007) reported in this issue suggest that tRNA trafficking and the transcription factor Gcn4 are key intermediates in the process by which yeast cells detect DNA damage and delay cell-cycle progression at the G1 to S phase transition.
Department of Molecular and Cellular Biology, University of Arizona, Life Sciences South 546, P.O. Box 210106, Tucson, AZ 85721-0106, USA. tweinert@email.arizona.edu
Ted
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Anita K
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Hopper
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D050976:Basic-Leucine Zipper Transcription Factors; D002453:Cell Cycle / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D018816:Genes, cdc / Q000502:physiology; D008954:Models, Biological; D012343:RNA, Transfer / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C501391:GCN4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D012343:RNA, Transfer