Ubiquitin domain proteins in disease.
The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Madsen
Louise
L
Insitute of Molecular Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Schulze
Andrea
A
Seeger
Michael
M
Hartmann-Petersen
Rasmus
R
D000818:Animals; D004195:Disease Models, Animal; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000235:genetics; D025801:Ubiquitin / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism
D025801:Ubiquitin