Anti-inflammatory effects of low-intensity extremely high-frequency electromagnetic radiation: frequency and power dependence.
Using a model of acute zymosan-induced footpad edema in NMRI mice, the frequency and power dependence of anti-inflammatory effect of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR) was found. Single whole-body exposure of animals to EHF EMR at the intensity of 0.1 mW/cm(2) for 20 min at 1 h after zymosan injection reduced both the footpad edema and local hyperthermia on average by 20% at the frequencies of 42.2, 51.8, and 65 GHz. Some other frequencies from the frequency range of 37.5-70 GHz were less effective or not effective at all. At fixed frequency of 42.2 GHz and intensity of 0.1 mW/cm(2), the effect had bell-shaped dependence on exposure duration with a maximum at 20-40 min. Reduction of intensity to 0.01 mW/cm(2) resulted in a change of the effect dependence on exposure duration to a linear one. Combined action of cyclooxygenase inhibitor sodium diclofenac and EHF EMR exposure caused a partial additive effect of decrease in footpad edema. Combined action of antihistamine clemastine and EHF EMR exposure caused a dose-dependent abolishment of the anti-inflammatory effect of EHF EMR. The results obtained suggest that arachidonic acid metabolites and histamine are involved in realization of anti-inflammatory effects of low-intensity EHF EMR.
Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region, Russia. gapeyev@icb.psn.ru
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Gapeyev
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Mikhailik
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NK
Chemeris
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004307:Dose-Response Relationship, Radiation; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000532:radiotherapy*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D008872:Microwaves / Q000627:therapeutic use*; D011829:Radiation Dosage; D016896:Treatment Outcome; D015054:Zymosan
D000893:Anti-Inflammatory Agents; D015054:Zymosan