Variants in the FTO gene are associated with common obesity in the Belgian population.
Three independent studies, of which two genome-wide scans, have reported an association between SNPs in the FTO (Fat mass and obesity associated) gene and obesity, in different European cohorts. We selected the SNPs with the strongest evidence for association from the first two studies and genotyped 1099 obese patients and 268 healthy control individuals. Both SNPs were significantly associated with obesity, enabling us to replicate earlier findings from Caucasian cohorts in a Belgian population sample.
Center for Medical Genetics, Department of Biomedical Sciences, University of Antwerp (UA) and University of Antwerp Hospital, Antwerp, Belgium. armand.peeters@ua.ac.be
Armand
A
Peeters
Sigri
S
Beckers
An
A
Verrijken
Peter
P
Roevens
Pieter
P
Peeters
Luc
L
Van Gaal
Wim
W
Van Hul
D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001530:Belgium / Q000453:epidemiology; D015992:Body Mass Index; D015331:Cohort Studies; D014644:Genetic Variation; D006801:Humans; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human