Vogt-Koyanagi-Harada syndrome in a Greenlandic Inuit.
OBJECTIVE
To report a case of Vogt-Koyanagi-Harada syndrome (VKH) in an Inuit.


METHODS
We carried out a medical evaluation and human leucocyte antigen (HLA) genotyping.


RESULTS
A 36-year-old male Inuit developed severely decreased vision, intense headache and vertigo over a 3-week period. Ocular examination revealed panuveitis with bilateral serous retinal detachment and optic nerve head oedema. There was no history of ocular trauma or evidence suggestive of other disease entities. The patient responded well to high-dose systemic prednisolone. Vitiligo presented late in the course.


CONCLUSIONS
This case report describes the first published case of VKH in a patient of Inuit ancestry. The patient was homozygous for HLA-DR4, a genotype previously associated with VKH.
Ostergaard
Jens
J
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. j.oe@email.dk
Goldschmidt
Ernst
E
Andersen
Nis
N
D000328:Adult; D005654:Fundus Oculi; D005838:Genotype; D005938:Glucocorticoids / Q000627:therapeutic use; D006116:Greenland / Q000453:epidemiology; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D004930:Inuit / Q000208:ethnology*; D008297:Male; D015864:Panuveitis / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology; D011239:Prednisolone / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology*; D014792:Visual Acuity
D005938:Glucocorticoids; D006680:HLA Antigens; D011239:Prednisolone