Migration of dendritic cell subsets and their precursors.
The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a consequence of their localization within tissues and their specialized capacity for mobilization. The migration of a given DC subset is typified by a restricted capacity for recirculation, contrasting markedly with T cells. Routes of DC migration into lymph nodes differ notably for distinct DC subsets. Here, we compare the distinct migratory patterns of plasmacytoid DCs (pDCs), CD8alpha(+) DCs, Langerhans cells, and conventional myeloid DCs and discuss how the highly regulated patterns of DC migration in vivo may affect their roles in immunity. Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration.
Randolph
Gwendalyn J
GJ
Department of Gene and Cell Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA. gwendalyn.randolph@mssm.edu
Ochando
Jordi
J
Partida-Sánchez
Santiago
S
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D002633:Chemotaxis / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008196:Lymph / Q000166:cytology; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology