Synthesis of new bisaryl cyclopentathiophene and thienocyclopentoxazolidine derivatives as potential cytotoxic agents.
The synthesis of new bisaryl thienocyclopentoxazolidine derivatives was achieved through a Suzuki cross-coupling procedure with the aim to enhance the previously reported cytotoxicity of the series. The biological activity, evaluated in the NCI's in vitro human disease-oriented tumor cell line screening panel, was however partially conserved by the pharmacomodulations.
Centre d'Etudes et de Recherche sur le Médicament de Normandie UFR des Sciences Pharmaceutiques Université de Caen Basse Normandie, 5 rue Vaubénard, 14032 Caen cedex France.
Ziad
Z
Omran
Patrick
P
Dallemagne
Sylvain
S
Rault
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001966:Bromine / Q000737:chemistry; D045744:Cell Line, Tumor; D003432:Cross-Linking Reagents / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D003517:Cyclopentanes; D006841:Hydrocarbons, Aromatic; D010080:Oxazoles; D013876:Thiophenes; C064210:oxazolidine; D001966:Bromine