[An update on Candida dubliniensis].
Eleven years ago, Irish authors, using molecular biology, demonstrated the existence of Candida dubliniensis, a new species of Candida close to Candida albicans. Initially isolated from AIDS patients with oral candidiasis, this species was detected, even in immunocompetent patients. Recently, with new, easy to implement identification tests (latex, immunochromatography), numerous epidemiological studies were undertaken. In most studies, C. dubliniensis was most often identified in the oral cavity. In the absence of HIV infection, the proportion C. dubliniensis/C. albicans ranged from 1 to 5% but it increased to 15-20% in case of HIV infection. It should be stressed that, from an experimental point of view, the acquisition of a secondary resistance to fluconazole is more quickly obtained with C. dubliniensis that with C. albicans, this resistance remains exceptionally observed in clinical observations.
Laboratoire de parasitologie-mycologie, groupe hospitalier Cochin-Saint-Vincent-de-Paul, Assistance publique-Hôpitaux de Paris, université Paris-Descartes, Paris, France. andre.paugam@cch.aphp.fr
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D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology*; D002175:Candida / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D002176:Candida albicans / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000175:diagnosis*; D005838:Genotype; D006801:Humans; D014774:Virulence