Experimental analysis of a new algorithm for partial haplotype completion.
This paper deals with the computational problem of inferring complete information on haplotypes from haplotypes with missing data. This problem is one of the main issues in haplotyping, as the current DNA sequencing technology often produces haplotypes with missing bases and therefore the complete information on haplotypes has to be inferred through computational methods. In this paper, we propose a new algorithmic approach to the problem that assumes both the Coalescent and the Minimum Entropy models and we provide an experimental analysis relating it to the previously investigated approaches. In particular, the reconstruction of a perfect phylogeny from haplotypes with missing data is addressed.
Paola
P
Bonizzoni
Gianluca
G
Della Vedova
Riccardo
R
Dondi
Lorenzo
L
Mariani
D000465:Algorithms; D001483:Base Sequence; D006239:Haplotypes; D010802:Phylogeny; D017422:Sequence Analysis, DNA