Molecular modelling studies of four stranded quadruplexes containing a 3'-3' or 5'-5' inversion of polarity site.
Recently we reported a preliminary study on the structure of two novel quadruplex structures, Q33 and Q55, formed by the oligodeoxynucleotides (5)'TGG(3)'-(3)'GGT(5)' and (3)'TGG(5)'-(5)'GGT(3)', respectively. Here we report their solution structures at the atomic level. The obtained structures reveal that Q55 and Q33 possess a different stacking among G-quartets and different twist angle (and therefore different helical winding) at the inversion of polarity level.
Virno
Ada
A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy.
Zaccaria
Francesco
F
Virgilio
Antonella
A
Esposito
Veronica
V
Galeone
Aldo
A
Mayol
Luciano
L
Randazzo
Antonio
A
D001483:Base Sequence; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides