An evolutionary approach to major histocompatibility diversity based on allele supertypes.
Human leukocyte antigens are traditionally classified by serologic or molecular techniques into a bewildering variety of alleles. It is generally believed that this allelic diversity is maintained by selection pressures for inbreeding avoidance and/or maximal immune system diversity. While the usual antigen-based classification of individual alleles may be most appropriate in the artificial situation of tissue transplantation, we hypothesize that a functional classification based on allele supertypes may represent a more biologically relevant way to view MHC diversity in the contexts of mate choice and disease pathogenesis. Furthermore, immune system diversity could be quantitatively estimated by calculating a Supertype Diversity Index (SDI) which is the number of different MHC supertypes possessed by an individual. This hypothesis generates a number of testable predictions. First, it predicts that a reduced inherited diversity of MHC allele supertypes may predispose to the development of malignancies because of a decreased native ability to present different tumor-associated antigens. Furthermore, specific autoimmune diseases may be associated with the presence or absence of a particular MHC supertype rather than a particular MHC haplotype. In transplant medicine, it is possible that unmatched alleles may trigger a weaker foreign antigen response if they are matched by allele supertype. Finally, there have been several studies documenting dissortative mating in humans for dissimilar MHC alleles. We predict that natural selection should favor maximization of the heterozygosity of allele supertypes instead of the heterozygosity of individual alleles and that the previously observed dissortative mating may actually be an adaptive strategy to maximize allele supertype diversity.
Naugler
Christopher
C
Department of Pathology and Laboratory Medicine, Dalhousie University, 5788 University Avenue, Halifax, Nova Scotia, Canada B3H 2Y9. naugler@dal.ca
Liwski
Robert
R
D000483:Alleles; D000939:Epitopes; D014644:Genetic Variation; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006579:Heterozygote; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007107:Immune System; D008285:Major Histocompatibility Complex; D008962:Models, Theoretical; D011110:Polymorphism, Genetic
D000939:Epitopes; D006680:HLA Antigens