A structural perspective on mechanism and function of the cytochrome bc (1) complex.
The cytochrome bc (1) complex is a fundamental component of the energy conversion machinery of respiratory and photosynthetic electron transfer chains. The multi-subunit membrane protein complex couples electron transfer from hydroquinone to cytochrome c to the translocation of protons across the membrane, thereby substantially contributing to the proton motive force that is used for ATP synthesis. Considerable progress has been made with structural and functional studies towards complete elucidation of the Q cycle mechanism, which was originally proposed by Mitchell 30 years ago. Yet, open questions regarding key steps of the mechanism still remain. The role of the complex as a major source of reactive oxygen species and its implication in pathophysiological conditions has recently gained interest.
Hunte
Carola
C
Dept. Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438, Frankfurt, Germany. carola.hunte@mpibp-frankfurt.mpg.de
Solmaz
Sozanne
S
Palsdóttir
Hildur
H
Wenz
Tina
T
D000255:Adenosine Triphosphate / Q000737:chemistry*; D003580:Cytochromes / Q000737:chemistry; D014450:Electron Transport Complex III / Q000737:chemistry*; D004583:Electrons; D006418:Heme / Q000737:chemistry; D006873:Hydroquinones / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000737:chemistry; D011487:Protein Conformation; D011522:Protons; D017382:Reactive Oxygen Species; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013379:Substrate Specificity
D003580:Cytochromes; D006873:Hydroquinones; D008565:Membrane Proteins; D010743:Phospholipids; D011522:Protons; D017382:Reactive Oxygen Species; D006418:Heme; D000255:Adenosine Triphosphate; D014450:Electron Transport Complex III