[Reactive oxygen and nitrogen species in inflammatory process].
Reactive oxygen species (ROS) are generated in every cell during normal oxidation. The most important ROS include: superoxide anion (O2*-), hydroxyl radical (OH*), hydroperoxyl radical (HO2*), hydrogen peroxide (H2O2) and singlet oxygen ((1)O2*-). Reactive oxygen species can react with key cellular structures and molecules altering their biological function. Similarly reactive nitrogen species (RNS) such as nitric oxide (NO) or peroxinitrite anion (ONOO-) have physiological activity or reacts with different types of molecules to form toxic products. ROS and RNS are important in process of energy generation, lipids peroxidation, protein and DNA oxidation, nitration, nitrosation or nitrosylation and catecholamine response. Reactive oxygen/nitrogen species are neutralized by enzymatic activity or natural antioxidants that stop the initial formation of radicals. Overproduction of ROS or RNS results in "oxidative" or "nitrosative" stress which contributes to variety of pathological processes typical for different cancer, neurodegenerative, viral, toxic or inflammatory diseases.
Rutkowski
Ryszard
R
Akademia Medyczna w Białymstoku, Samodzielna Pracownia Diagnostyki Oddechowej i Bronchoskopii. rutkowski@csk.pl
Pancewicz
Sławomir A
SA
Rutkowski
Krzysztof
K
Rutkowska
Joanna
J
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism* / Q000494:pharmacology; D007249:Inflammation / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism* / Q000494:pharmacology
D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase