An effective desiccant system to regulate the humidity inside the chambers of the solid dosage forms.
The most common way to protect moisture-sensitive pharmaceutical powders is to utilize protective packaging. However, the most convenient package materials are all permeable to water molecules to some extent and limited protection is normally achieved with this arrangement even though desiccants are employed. In the present study we introduce a novel system that can regulate the internal humidity of the containers used with solid dosage forms for a desired time at a requested level. Instead of the widely used solid adsorbents the system utilizes saturated salt solutions loaded in desiccant bags made of various polymer materials with appropriate permeation properties. By utilizing salt solutions the size of the desiccant bag can be further reduced. A wide variety of commonly used powder chambers and desiccant bags are tested, proving the effectiveness of the introduced system.
Department of Physics, University of Turku, Turku, Finland. vlehto@utu.fi
Vesa-Pekka
VP
Lehto
Ida
I
Erling
D003890:Desiccation / Q000379:methods*; D004349:Drug Packaging; D006813:Humidity; D013607:Tablets; D013678:Technology, Pharmaceutical
D013607:Tablets