Medical and technical protocol for automatic navigation of a wireless device in the carotid artery of a living swine using a standard clinical MRI system.
A 1.5 mm magnetic sphere was navigated automatically inside the carotid artery of a living swine. The propulsion force, tracking and real-time capabilities of a Magnetic Resonance Imaging (MRI) system were integrated into a closed loop control platform. The sphere was released using an endovascular catheter approach. Specially developed software is responsible for the tracking, propulsion, event timing and closed loop position control in order to follow a 10 roundtrips preplanned trajectory on a distance of 5 cm inside the right carotid artery of the animal. Experimental protocol linking the technical aspects of this in vivo assay is presented. In the context of this demonstration, many challenges which provide insights about concrete issues of future nanomedical interventions and interventional platforms have been identified and addressed.
Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montréal (EPM), Campus de l'université de Montréal, P.O. Box 6079, Station Centre-ville, Montréal, Québec, Canada H3C 3A7. Sylvain.Martel@polymtl.ca
Sylvain
S
Martel
Jean-Baptiste
JB
Mathieu
Ouajdi
O
Felfoul
Arnaud
A
Chanu
Eric
E
Aboussouan
Samer
S
Tamaz
Pierre
P
Pouponneau
L'Hocine
L
Yahia
Gilles
G
Beaudoin
Gilles
G
Soulez
Martin
M
Mankiewicz
D000818:Animals; D001709:Biotechnology / Q000379:methods; D002339:Carotid Arteries / Q000033:anatomy & histology*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation / Q000379:methods*; D008846:Micromanipulation / Q000295:instrumentation / Q000379:methods*; D012371:Robotics / Q000295:instrumentation* / Q000379:methods*; D013552:Swine; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods