[Polycationic catalysts for phosphodiester bond cleavage on the basis of 1,4-diazabicyclo[2.2.2]octane].
A number of tetracationic compounds capable of phosphodiester bond cleavage within a 21 -membered ribooligonucleotide were designed and synthesized. The artificial ribonucleases represent two residues of quaternized 1,4-diazabicyclo[2.2.2]octane bearing alkyl substituents of various lengths and connected with a rigid linker. The efficiency of cleavage of phosphodiester bonds in an RNA target depends on the linker structure and the length of alkyl substituent.
Burakova
E A
EA
Kovalev
N A
NA
Kuznetsova
I L
IL
Zenkova
M A
MA
Vlasov
V V
VV
Sil'nikov
V N
VN
D001483:Base Sequence; D002384:Catalysis; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry*; D000071228:Polyelectrolytes; D012313:RNA / Q000737:chemistry*; D012260:Ribonucleases / Q000138:chemical synthesis / Q000737:chemistry*
D009843:Oligoribonucleotides; D010879:Piperazines; D011073:Polyamines; D000071228:Polyelectrolytes; D012313:RNA; D012260:Ribonucleases; C007306:triethylenediamine