Contributions to the study of Trichinella spiralis TSL-1 antigens in host immunity.
The observation on different hosts infected with Trichinella spiralis that recognized similar muscle larvae (ML) antigens and the fact that different monoclonal antibodies (mAb) had a similar reactivity to ML components prompted a proposal to define a useful classification system for these antigens. For this purpose, an international workshop provided a platform for the classification of T. spiralis antigens. ML antigens were classified in eight groups -- Trichinella spiralis larvae groups, TSL-1 to TSL-8. TSL-1 antigens are highly immunogenic and a number of important studies have been performed to analyse the role of these antigens in the host-parasite interplay. In this context, we have focused on the analysis of the role of TSL-1 antigens in the induction of innate immune responses with particular emphasis on the activation of mast cells (MC) by an IgE-independent pathway. These studies provided evidence on the role of mediator release from TSL-1-activated MC in the development of Type 2 immune responses. The protective role of TSL-1 in T. spiralis-infected mice has been described. In addition, it has been demonstrated that the use of TSL-1 antigens allows for a more sensitive and specific diagnosis of human and animal trichinellosis.
Yépez-Mulia
L
L
UIMEIP-Pediatria, CMN-Siglo XXI, IMSS, Mexico City, Mexico.
Hernández-Bello
R
R
Arizmendi-Puga
N
N
Fonseca-Liñán
R
R
Ortega-Pierres
G
G
D000818:Animals; D000947:Antigens, Helminth / Q000145:classification / Q000276:immunology*; D006801:Humans; D007814:Larva / Q000276:immunology; D008407:Mast Cells / Q000276:immunology / Q000469:parasitology*; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000175:diagnosis / Q000276:immunology*
D000947:Antigens, Helminth