Organic solvent-free, enantio- and diastereoselective, direct Mannich reaction in the presence of water.
An organocatalyst-mediated, asymmetric Mannich reaction in the presence of water without using organic solvents has been developed. A highly reactive siloxytetrazole hybrid catalyst has been developed for the reaction of dimethoxyacetaldehyde, while the sodium salt of siloxyproline is an effective catalyst of alpha-imino glyoxylate. Excellent enantioselectivity can be realized, and the usage of organic solvents can be reduced compared to the conventional reactions in organic solvents.
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
Yujiro
Y
Hayashi
Tatsuya
T
Urushima
Seiji
S
Aratake
Tsubasa
T
Okano
Kazuki
K
Obi