Sequential palladium-catalyzed coupling reactions on solid-phase.
Six-types of palladium-catalyzed coupling, Mizoroki-Heck, Migita-Stille, Sonogashira, carbonylative esterification, carbonylative Stille, and carbonylative Sonogashira reactions, were performed on a polymer support. The above coupling reactions of m- and p-substituted aromatic rings, followed by carbonylative esterification with m- and p-substituted anisol derivatives were carried out in a combinatorial manner. Acid cleavage from the polymer-support provided the conjugated aromatic ring systems 1 and 2, which are the core parts of rodlike liquid crystals.
Department of Applied Chemistry, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo 152-8552, Japan.
Takayuki
T
Doi
Hitoshi
H
Inoue
Masatoshi
M
Tokita
Junji
J
Watanabe
Takashi
T
Takahashi
D001555:Benzene Derivatives / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D050866:Liquid Crystals / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D011108:Polymers; D054852:Small Molecule Libraries; D010165:Palladium