Simulated neonatal exposure to DEHP and MEHP from PVC enteral nutrition products.
The leaching of di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) from medical products made of polyvinyl-chloride (PVC) to enteral nutrition (EN) for neonatal patients was determined in a simulated study. The study simulated a typical case of EN administration to a neonatal patient (body weight, 3 kg) in a neonatal care unit (temperature, 25 degrees C); the medical products used were an irrigator and catheter containing DEHP (9.1-31.8%, w/w) as a plasticizer. The worst-case daily exposures of the neonatal patient to DEHP and MEHP by the administration of EN were estimated to be 148 and 3.72 microg/(kg day), respectively, as assessed from the levels of these compounds leaching from the medical products to the EN. The use of DEHP-free medical products reduced the exposure of DEHP and MEHP to the minimum levels contained in the EN at preparation. A transition to DEHP-free medical products for neonatal patients would be effective in reducing the exposure of neonatal patients to DEHP via EN administration.
Division of Food Chemistry, Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. sts-tkt@iph.pref.osaka.jp
Satoshi
S
Takatori
You
Y
Okamoto
Yoko
Y
Kitagawa
Shinjiro
S
Hori
Shun-Ichiro
S
Izumi
Tsunehisa
T
Makino
Hiroyuki
H
Nakazawa
D002851:Chromatography, High Pressure Liquid; D004051:Diethylhexyl Phthalate / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D004750:Enteral Nutrition / Q000009:adverse effects* / Q000295:instrumentation; D004867:Equipment Design; D005506:Food Contamination / Q000517:prevention & control*; D006801:Humans; D041943:Infant Formula / Q000737:chemistry*; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D010968:Plasticizers / Q000009:adverse effects / Q000032:analysis*; D011143:Polyvinyl Chloride / Q000009:adverse effects / Q000737:chemistry*; D018570:Risk Assessment; D021241:Spectrometry, Mass, Electrospray Ionization; D013059:Spectrum Analysis, Raman; D053719:Tandem Mass Spectrometry
D010968:Plasticizers; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate