[Role of nuclear factor-kappaB in providing interactions of human neutrophils and epithelial cells from oral cavity with Candida albicans].
Contribution of intracellular signal pathways associated with nuclear factor kappaB (NF-kappaB) in realization of interactions of human neutrophils and epithelial cells from oral cavity with Candida albicans was studied. Supression of NF-kappaB in epitheliocytes resulted in decreased adsorption of C. albicans to buccal cells (buccal mucosa). Inhibition of NF-kappaB led to decrease in receptor-dependent oxidative activity of neutrophils in systems with native and IgG-opsonized C. albicans as well as to increase of phagocytic activity during contact with C3b-/iC3b-opsonized C. albicans. It has been concluded that NF-kappaB participates in regulation of specific interactions of neurophils and epitheliocytes with C. albicans.
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Zaslavskaia
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Maianskiĭ
D000293:Adolescent; D000328:Adult; D002176:Candida albicans / Q000502:physiology*; D002448:Cell Adhesion; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009061:Mouth Mucosa / Q000378:metabolism*; D016328:NF-kappa B / Q000502:physiology*; D009504:Neutrophils / Q000378:metabolism*; D009895:Opsonin Proteins; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000276:immunology; D015398:Signal Transduction
D007074:Immunoglobulin G; D016328:NF-kappa B; D009895:Opsonin Proteins