New 1-indanone thiosemicarbazone derivatives active against BVDV.
Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus.
Cátedra de Química Orgánica III, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina.
Liliana M
LM
Finkielsztein
Eliana F
EF
Castro
Lucas E
LE
Fabián
Graciela Y
GY
Moltrasio
Rodolfo H
RH
Campos
Lucía V
LV
Cavallaro
Albertina G
AG
Moglioni
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
C000595050:5,6-dimethoxy-1-indanone thiosemicarbazone; D000998:Antiviral Agents; D007189:Indans; D013882:Thiosemicarbazones; C013352:indacrinone