A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.
We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.
Lazrek
H B
HB
Faculté des Sciences Semlalia, Laboratoire de Chimie Bio-Organique, Marrakech, Maroc.
Vasseur
J J
JJ
Secrist
Jack
J
Engels
Joachim W
JW
D000812:Anhydrides / Q000737:chemistry; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry; D002460:Cell Line; D019281:Dimerization; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D005977:Glutarates / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
D000812:Anhydrides; D019380:Anti-HIV Agents; D004337:Drug Carriers; D005977:Glutarates; D019259:Lamivudine; C079643:glutaric anhydride