Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.
Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.
Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Diana
D
Barthel
Martin
M
Schlitzer
Gabriele
G
Pradel
D000818:Animals; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development*; D014176:Protein Biosynthesis / Q000187:drug effects; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D013997:Time Factors; D014769:Virginiamycin / Q000494:pharmacology*
D048628:Ketolides; D011500:Protein Synthesis Inhibitors; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; C106791:telithromycin