[Constructing gene regulatory network from microarray data].
With the rapid deposition of the microarray data in recent years, microarray data has increasingly become an important data source for bioinformatics research. Based on microarray date, constructing gene regulatory networks has also become a hotspot. By constructing the gene regulatory network, we can identify the complicated regulatory relationships, uncover the regulatory patterns in the cell, and gain the systematic view for biological process. Recently, many algorithms have also been introduced in this field to determine gene regulatory networks based on such high-throughput microarray data. In this paper, we review the development of these algorithms, with a particular emphasis on their improvement of theory and method. At last, we present the available software and platform and discuss the development trends in this field.
State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China. liuwanlin@hupo.org.cn
Wan-Lin
WL
Liu
Dong
D
Li
Yun-Ping
YP
Zhu
Fu-Chu
FC
He
D000465:Algorithms; D000818:Animals; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software