Objective versus subjective assessment of methylphenidate response.
Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 +/- 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.
ADHD Unit, Geha Mental Health Center, P.O. Box 102, Petach Tikva, 49100, Israel. imanor@clalit.org.il
Iris
I
Manor
Sheera
S
Meidad
Gil
G
Zalsman
Zvi
Z
Zemishlany
Sam
S
Tyano
Abraham
A
Weizman
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D012649:Self Concept; D012720:Severity of Illness Index
D000697:Central Nervous System Stimulants; D008774:Methylphenidate