Antibacterial lignans and triterpenoids from Rostellularia procumbens.
One new lignan, rostellulin A ( 1), four known lignans, justin B ( 2), justicidin C ( 3), cilinaphthalide A ( 4), and justicidin A ( 5), and four known triterpenoids, ursolic acid ( 6), euscaphic acid ( 7), 2 alpha-hydroxyursolic acid ( 8), and tormentic acid ( 9), have been isolated from the whole plants of Rostellularia procumbens. Their structures were established on the basis of spectral data, including extensive NMR experiments. To our knowledge, compounds 6 - 9 are known compounds but not previously isolated from R. procumbens, 4 was previously reported from other Rostellularia species. Antibacterial activities of 1 - 9 were evaluated against eight bacterial strains with the agar dilution method, and they were found to possess antimicrobial activity with MIC values in the range of 1.56 - 100 microg/mL. None of the lignans exhibited cytotoxic activity against HCT-8 and Bel-7402 cells at concentrations up to 5 microg/mL.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P R China.
Yongli
Y
Zhang
Fukai
F
Bao
Juanjuan
J
Hu
Shengwang
S
Liang
Yu
Y
Zhang
Guanhua
G
Du
Caijun
C
Zhang
Yongxian
Y
Cheng
D027901:Acanthaceae; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D017705:Lignans; D010936:Plant Extracts; D014315:Triterpenes