Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds?
BACKGROUND
Surgeons may prescribe oral quinolones after auricular procedures to prevent postoperative infections, especially those caused by Pseudomonas aeruginosa.


OBJECTIVE
This study compares the efficacy of levofloxacin and local wound care to local wound care alone in preventing postoperative infection of auricular second-intention wounds.


METHODS
This study was a prospective, randomized trial of 84 consecutive patients (82 in the final analysis) who underwent Mohs micrographic surgery for an auricular neoplasm and had a wound left to heal by second intention. After surgery, patients were randomly assigned to receive either local wound care or local wound care with concurrent 500 mg of levofloxacin by mouth daily.


RESULTS
Overall, 85.4% of patients had no complications. Complications included 12.2% of patients with inflammatory chondritis and 2.4% of patients with infection. No infections with P. aeruginosa were observed. No statistical significance was observed between the two treatment groups.


CONCLUSIONS
Levofloxacin is not necessary to prevent postoperative infections of auricular second-intention wounds after Mohs surgery.
Department of Dermatology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45207, USA.
Erica A
EA
Mailler-Savage
Kenneth W
KW
Neal
Tonya
T
Godsey
Brian B
BB
Adams
Hugh M
HM
Gloster
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D054644:Ear Auricle / Q000601:surgery*; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000009:adverse effects*; D015242:Ofloxacin / Q000627:therapeutic use*; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000209:etiology
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin