[Cilliary neurotrophic factor in tick-borne encephalitis].
OBJECTIVE
To evaluate concentrations of cilliary neutrophic factor (CNTF) in serum and cerebrospinal fluid of patients with tick-borne encephalitis (TBE) and bacterial meningitis.


METHODS
49 patients (14 females and 35 males), aged 19 to 62 were examined. Patients were divided into three groups: group I--23 patients (47%) with diagnosed TBE, group II--16 patients (33%) with bacterial meningitis and 10 (20%) healthy individuals as control group. The examination was performed twice before and after 4-weeks treatment. In achieved results CNTF concentration in serum from group I and II in both examinations was significantly higher compared to control group.


RESULTS
Patients with TBE showed higher serum CNTF concentration compared to group with bacterial meningitis in both examinations as well. In examination 1 cerebrospinal fluid CNTF concentration of both groups was significantly higher in comparison to control group. Examined cytokine CSF concentration was higher in group with bacterial meningitis. After treatment CNTF concentration decreased significantly in group I and II. In group I CNTF concentration was comparable to control group.


CONCLUSIONS
Concentration of CNTF in csf could be used as a marker of the inflammatory process in the central nervous system.
Zdrodowska
Agnieszka
A
Wojewódzki Szpital Specjalistyczny w Białymstoku, Oddział Chorób Zakaźnych i Neuroinfekcji. draganr1@wp.pl
Swierzbińska
Renata
R
Kondrusik
Maciej
M
Pancewicz
Sławomir A
SA
Zajkowska
Joanna M
JM
Grygorczuk
Sambor
S
Hermanowska-Szpakowicz
Teresa
T
D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D020934:Ciliary Neurotrophic Factor / Q000097:blood* / Q000134:cerebrospinal fluid; D004669:Encephalitis Viruses, Tick-Borne / Q000737:chemistry / Q000302:isolation & purification*; D004675:Encephalitis, Tick-Borne / Q000097:blood* / Q000134:cerebrospinal fluid / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000097:blood* / Q000134:cerebrospinal fluid / Q000175:diagnosis; D008587:Meningitis, Viral / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis; D008875:Middle Aged; D012016:Reference Values
D015415:Biomarkers; D020934:Ciliary Neurotrophic Factor