DNA containing non-nucleosidic phenanthrene building blocks with asymmetrical linkers.
The synthesis and hybridization properties of oligonucleotides containing phenanthrene building blocks with non-nucleosidic linkers of different length are described. It was found that the length of the linkers, as well as the combination of unequal linkers can have a substantial influence on the thermal stability of the modified DNA.
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Simon M
SM
Langenegger
Vladimir L
VL
Malinovskii
Daniel
D
Wenger
Sarah
S
Werder
Robert
R
Häner
D001483:Base Sequence; D015195:Drug Design; D004355:Drug Stability; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry*; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; D010616:Phenanthrenes