Cancer chemopreventive effects of lactic acid bacteria.
Lactic acid bacteria (LAB) provide several potential health and nutritional benefits, including improving the nutritional value of food, controlling serum cholesterol levels, and controlling some types of cancer. Numerous in vitro, in vivo, human, and epidemiological studies have provided evidence of the chemopreventive effects of LAB on colon, bladder, liver, breast, and gastric cancers. These effects act via diverse mechanisms, including alteration of the gastrointestinal microflora, enhancement of the host's immune response, and antioxidative and antiproliferative activities. This review discusses the recent progresses on the chemopreventive effects of LAB on specific cancer types and the underlying molecular mechanisms.
Kim
Jong-Eun
JE
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea
Kim
Ji Yeon
JY
Lee
Ki Won
KW
Lee
Hyong Joo
HJ
D000970:Antineoplastic Agents / Q000378:metabolism*; D001644:Bifidobacterium / Q000502:physiology*; D005260:Female; D006801:Humans; D017045:Lactococcus / Q000502:physiology*; D008297:Male; D009369:Neoplasms / Q000517:prevention & control*
D000970:Antineoplastic Agents