Multivariate analysis of complex gene expression and clinical phenotypes with genetic marker data.
This paper summarizes contributions to group 12 of the 15th Genetic Analysis Workshop. The papers in this group focused on multivariate methods and applications for the analysis of molecular data including genotypic data as well as gene expression microarray measurements and clinical phenotypes. A range of multivariate techniques have been employed to extract signals from the multi-feature data sets that were provided by the workshop organizers. The methods included data reduction techniques such as principal component analysis and cluster analysis; latent variable models including structural equations and item response modeling; joint multivariate modeling techniques as well as multivariate visualization tools. This summary paper categorizes and discusses individual contributions with regard to multiple classifications of multivariate methods. Given the wide variety in the data considered, the objectives of the analysis and the methods applied, direct comparison of the results of the various papers is difficult. However, the group was able to make many interesting comparisons and parallels between the various approaches. In summary, there was a consensus among authors in group 12 that the genetic research community should continue to draw experiences from other fields such as statistics, econometrics, chemometrics, computer science and linear systems theory.
Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada. joseph@utstat.toronto.edu
Joseph
J
Beyene
David
D
Tritchler
Shelley B
SB
Bull
Kevin C
KC
Cartier
Gudrun
G
Jonasdottir
Aldi T
AT
Kraja
Na
N
Li
Nora L
NL
Nock
Elena
E
Parkhomenko
J Sunil
JS
Rao
Catherine M
CM
Stein
Rinku
R
Sutradhar
Sandra
S
Waaijenborg
Ke-Sheng
KS
Wang
Yuanjia
Y
Wang
Pavel
P
Wolkow
D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D015999:Multivariate Analysis; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers