Small animal radiation research platform: imaging, mechanics, control and calibration.
In cancer research, well characterized small animal models of human cancer, such as transgenic mice, have greatly accelerated the pace of development of cancer treatments. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those same models available for the development and evaluation of novel radiation therapies. In combination with advanced imaging methods, small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The SARRP will realistically model human radiation treatment methods in standard animal models. In this paper, we describe the mechanical and control structure of the system. This system requires accurate calibration of the x-ray beam for both imaging and radiation treatment, which is presented in detail in the paper.
Dept. of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Mohammad
M
Matinfar
Owen
O
Gray
Iulian
I
Iordachita
Chris
C
Kennedy
Eric
E
Ford
John
J
Wong
Russell H
RH
Taylor
Peter
P
Kazanzides
D000818:Animals; D001696:Biomechanical Phenomena / Q000295:instrumentation* / Q000379:methods; D002138:Calibration; D004195:Disease Models, Animal; D004780:Environment, Controlled; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011874:Radiometry / Q000295:instrumentation / Q000379:methods; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000295:instrumentation* / Q000379:methods; D012106:Research / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods / Q000662:veterinary