Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.
We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCC(ij)(0)) and their z-transforms (z(ij)(0)) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of z(ij)(0) successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sjögren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.
Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. omega@umn.edu
Apostolos P
AP
Georgopoulos
Elissaios
E
Karageorgiou
Arthur C
AC
Leuthold
Scott M
SM
Lewis
Joshua K
JK
Lynch
Aurelio A
AA
Alonso
Zaheer
Z
Aslam
Adam F
AF
Carpenter
Angeliki
A
Georgopoulos
Laura S
LS
Hemmy
Ioannis G
IG
Koutlas
Frederick J P
FJ
Langheim
J Riley
JR
McCarten
Susan E
SE
McPherson
José V
JV
Pardo
Patricia J
PJ
Pardo
Gareth J
GJ
Parry
Susan J
SJ
Rottunda
Barbara M
BM
Segal
Scott R
SR
Sponheim
John J
JJ
Stanwyck
Massoud
M
Stephane
Joseph J
JJ
Westermeyer
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001683:Biological Clocks; D001921:Brain / Q000503:physiopathology*; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D002648:Child; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*