Clip-phen conjugates for the specific cleavage of nucleic acids.
For the first time Clip-Phen (1) was conjugated to oligonucleotides to provide very efficient tools for the cleavage of nucleic acids at specific positions. The synthesis of the conjugates as well as the cleavage experiments are reported.
BIOMERIEUX, Molecular Biology Business Unit, Grenoble, France. alain.laurent@eu.biomerieux.com
Alain
A
Laurent
Michael
M
Wright
Ali
A
Laayoun
Bernard
B
Meunier
Ludivine
L
Tissot
Marguerite
M
Pitie
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000302:isolation & purification; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry*
C115240:Clip-phen; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; D010618:Phenanthrolines; D004247:DNA