Prevalence of hepatitis B and C serological markers among first-time blood donors in Brazil: a multi-center serosurvey.
Little data are available on the seroprevalence of, and risk factors for hepatitis B and C viruses (HBV and HCV) infection in Latin American countries. A multi-center serosurvey was conducted among 3,598 first-time blood donors (65% men) from Sao Paulo, Salvador and Manaus in Brazil. The gender-specific seroprevalences of antibodies against hepatitis B core antigen (anti-HBc) and of the hepatitis B surface antigen (HBsAg) in anti-HBc-positive sera were measured, and risk factors analyzed by gender. The gender-specific seroprevalences of antibodies against HCV (anti-HCV) were measured, but risk factors for HCV were not determined. Anti-HBc and HBsAg seroprevalences were not significantly different in men [101/2,341 (4.31%) and 4/2,229 (0.18%), respectively] and women [65/1,237 (5.25%) and 8/1,169 (0.68%), respectively], whereas the seroprevalence of anti-HCV was higher in women (12/1,238 [0.97%] vs. 9/2,353 [0.38%]; odds ratio [OR] = 2.49; 95% confidence interval [CI]: 1.0-6.0). No significant difference for HBV infection was found across the three study sites or by ethnic group. The seroprevalence of anti-HBc increased with age, but decreased with education level in both genders. Lifetime number of sexual partners was associated with anti-HBc prevalence among men (OR = 1.95; 95% CI: 1.2-3.1), but not women. The seroprevalence of HBV and HCV was low among Brazilian blood donors, and exposure increased with age in both genders.
Laboratório de Virologia do Instituto de Medicina Tropical, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil. nascimentoc@iarc.fr
Maria Claudia
MC
Nascimento
Philippe
P
Mayaud
Ester Cerdeira
EC
Sabino
Katia Luz
KL
Torres
Silvia
S
Franceschi
D001782:Blood Donors; D001938:Brazil / Q000453:epidemiology; D004279:DNA, Viral; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis* / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000032:analysis* / Q000097:blood; D006801:Humans; D008297:Male; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D012747:Sexual Partners
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies