Antifungal activity of some diaryl ethers.
Several diaryl ethers were synthesized and tested in vitro against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria alternate, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum and Alternaria brassicae. Compared to a commercial agricultural fungicide, hymexazol, especially compounds a, b, e, g and k were found to be more effective at 50 mug/ml against F. graminearum, F. oxysporum f. sp. vasinfectum and F. oxysporum f. sp. cucumarinum. Meantime, some structure-activity relationships were also observed.
Lab of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China. orgxuhui@nwsuaf.edu.cn
Hui
H
Xu
Kun-Zhong
KZ
Jian
Qiu
Q
Guan
Fei
F
Ye
Min
M
Lv
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010935:Plant Diseases / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D004987:Ethers