Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.
A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
Magdalena M
MM
Sauvage
Norbert J
NJ
Fortin
Cullen B
CB
Owens
Andrew P
AP
Yonelinas
Howard
H
Eichenbaum
D000818:Animals; D001522:Behavior, Animal; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology; D003216:Conditioning, Operant; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009812:Odorants; D009833:Olfactory Pathways / Q000503:physiopathology; D012372:ROC Curve; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000502:physiology*