[Lipid peroxidation before and after amputation of the lower extremity in patients with atherosclerotic gangrene].
Activity of lipid peroxidation processes in blood was studied in 60 patients with atherosclerotic gangrene of the lower extremity subjected to amputation of the extremity in a prospective controlled investigation. Activation of the lipid peroxidation processes with a lower number and less activity of the antioxidant system enzymes was demonstrated in patients with severe critical ischemia of lower extremities. The operation trauma was followed by further stress of the system of free radical oxidation of lipids. The increased concentration of lipid peroxidation products with a decreased or low level of activity of the antioxidant system enzymes allows prognosis of the development of purulent complications at the early postoperative period.
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Kuz'min
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Andreeva
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Zazdravnykh
D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000379:methods*; D050197:Atherosclerosis / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005734:Gangrene / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D035002:Lower Extremity / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care