Drosophila G9a is a nonessential gene.
Mammalian G9a is a euchromatic histone H3 lysine 9 (H3K9) methyltransferase essential for development. Here, we characterize the Drosophila homolog of G9a, dG9a. We generated a dG9a deletion allele by homologous recombination. Analysis of this allele revealed that, in contrast to recent findings, dG9a is not required for fly viability.
Seum
Carole
C
Department of Zoology and Animal Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.
Bontron
Séverine
S
Reo
Emanuela
E
Delattre
Marion
M
Spierer
Pierre
P
D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila / Q000201:enzymology* / Q000235:genetics* / Q000254:growth & development; D017353:Gene Deletion; D017344:Genes, Insect; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D007814:Larva / Q000201:enzymology / Q000254:growth & development; D009154:Mutation; D010641:Phenotype; D011496:Protein Methyltransferases; D011995:Recombination, Genetic
D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase