Comparative codon and amino acid composition analysis of Tritryps-conspicuous features of Leishmania major.
Comparative analyses of codon/amino acid usage in Leishmania major, Trypanosoma brucei and Trypanosoma cruzi reveal that gene expressivity and GC-bias play key roles in shaping the gene composition of all three parasites, and protein composition of L. major only. In T. brucei and T. cruzi, the major contributors to the variation in protein composition are hydropathy and/or aromaticity. Principle of Cost Minimization is followed by T. brucei, disregarded by T. cruzi and opposed by L. major. Slowly evolving highly expressed gene-products of L. major bear signatures of relatively AT-rich ancestor, while faster evolution under GC-bias has characterized the lowly expressed genes of the species by higher GC12-content.
Chanda
Ipsita
I
Department of Structural Biology and Bioinformatics, Indian Institute of Chemical Biology, Kolkata 700 032, India. ipsita_chanda@yahoo.co.in
Pan
Archana
A
Saha
Sanjoy Kumar
SK
Dutta
Chitra
C
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000596:Amino Acids / Q000235:genetics*; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D003062:Codon / Q000235:genetics*; D017124:Conserved Sequence; D005786:Gene Expression Regulation; D017125:Genes, Protozoan; D014644:Genetic Variation; D018320:Leishmania major / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D010271:Parasites / Q000235:genetics; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics; D014346:Trypanosoma brucei brucei / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
D000596:Amino Acids; D003062:Codon; D008562:Membrane Glycoproteins; D015800:Protozoan Proteins