The effect of progesterone on total brain tissue sialic acid levels in experimental epilepsy.
Epilepsy, the most common neurological disorder worldwide, changing cellular interactions and connectivity may have effects on sialic acid levels. A total of 80 mice were separated into 8 groups: the sham, control, pentylentetrazole (PTZ), PTZ plus progesterone, five dose progesterone, single dose progesterone, kindling, and kindling plus progesterone groups. Brains of each mice were extracted and were divided into five parts. The sialic acid levels were significantly different between the groups and also in the subgroups. The results suggested that progesterone may have an anti-seizure effect by decreasing sialic acid levels in mice. Further studies are needed to evaluate the role of progesterone on sialic acid levels and its role in the epilepsy pathogenesis.
Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. pence@gantep.edu.tr
Sadrettin
S
Pence
Mehmet
M
Bosnak
Naciye
N
Kurtul
Mete Gurol
MG
Ugur
Ibrahim
I
Erkutlu
Cahit
C
Bagci
Uner
U
Tan
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D007696:Kindling, Neurologic / Q000378:metabolism; D008297:Male; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D010433:Pentylenetetrazole; D011374:Progesterone / Q000008:administration & dosage / Q000502:physiology*; D011897:Random Allocation; D012640:Seizures / Q000378:metabolism / Q000517:prevention & control*
D011374:Progesterone; D019158:N-Acetylneuraminic Acid; D010433:Pentylenetetrazole