Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity.
Four IgE-binding epitopes have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum). They mainly correspond to electropositively charged regions protruding on the molecular surface of the modeled apple (Mal d 3), apricot (Pru ar 3), and plum (Pru d 3) allergens. Two of these epitopes consist of consensus epitopes structurally conserved among the lipid transfer protein allergens from the Rosaceae. Their occurrence in different lipid transfer protein allergens presumably accounts for the IgE-binding cross-reactivity often observed among different Rosaceae fruits. In this respect, LTP consist of phylogenetically- and structurally-related pan allergens. However, the IgE-binding cross-reactivity due to fruit lipid transfer protein has varying degrees of clinical relevance and this cross-reactivity is not necessarily accompanied by a cross-allergenicity to the corresponding fruits.
Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier-CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France.
Jean-Philippe
JP
Borges
Annick
A
Barre
Raphaël
R
Culerrier
Claude
C
Granier
Alain
A
Didier
Pierre
P
Rougé
D000485:Allergens / Q000276:immunology*; D000818:Animals; D052179:Antigens, Plant / Q000737:chemistry* / Q000276:immunology*; D002352:Carrier Proteins / Q000737:chemistry* / Q000276:immunology*; D016384:Consensus Sequence / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005638:Fruit / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D010940:Plant Proteins / Q000737:chemistry* / Q000276:immunology*; D011485:Protein Binding; D011817:Rabbits
D000485:Allergens; D052179:Antigens, Plant; D002352:Carrier Proteins; D000939:Epitopes; D010940:Plant Proteins; C511920:lipid transfer proteins, plant; D007073:Immunoglobulin E