Multispectral diffuse optical tomography with absorption and scattering spectral constraints.
We present a new method to simultaneously reconstruct the images of oxyhemoglobin, deoxyhemoglobin, and water concentrations, as well as the volume fraction images of the scattering particles using continuous wave multispectral diffuse optical tomography with the absorption and scattering spectral prior constraints. In this method, the nonlinear relationship between the reduced scattering coefficient and the volume fraction and the size of the particles is linearized, allowing direct reconstruction of the volume fraction of scattering particles in tissues. The method is validated by a series of numerical simulations, phantom experiments, and in vivo clinical experiments. The initial clinical results indicate that the volume fraction of scattering particles in a malignant tumor is higher than that in a benign tumor.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA.
Changqing
C
Li
Stephen R
SR
Grobmyer
Lin
L
Chen
Qizhi
Q
Zhang
Laurie L
LL
Fajardo
Huabei
H
Jiang
D000042:Absorption / Q000502:physiology*; D001834:Body Water; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis; D010316:Particle Size; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D041622:Tomography, Optical; D014867:Water / Q000032:analysis
D006454:Hemoglobins; D010108:Oxyhemoglobins; D014867:Water; C100003:deoxyhemoglobin