The weak-acid preservative sorbic acid is decarboxylated and detoxified by a phenylacrylic acid decarboxylase, PadA1, in the spoilage mold Aspergillus niger.
Resistance to sorbic and cinnamic acids is mediated by a phenylacrylic acid decarboxylase (PadA1) in Aspergillus niger. A. niger DeltapadA1 mutants are unable to decarboxylate sorbic and cinnamic acids, and the MIC of sorbic acid required to inhibit spore germination was reduced by approximately 50% in DeltapadA1 mutants.
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
Andrew
A
Plumridge
Malcolm
M
Stratford
Kenneth C
KC
Lowe
David B
DB
Archer
D001234:Aspergillus niger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D001565:Benzoates / Q000378:metabolism / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000378:metabolism*; D002934:Cinnamates / Q000378:metabolism / Q000494:pharmacology; D003653:Decarboxylation; D025141:Drug Resistance, Fungal / Q000235:genetics; D005520:Food Preservatives / Q000378:metabolism* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009154:Mutation; D013011:Sorbic Acid / Q000378:metabolism* / Q000494:pharmacology
D001565:Benzoates; D002934:Cinnamates; D005520:Food Preservatives; C029010:cinnamic acid; D002262:Carboxy-Lyases; C087194:phenylacrylic acid decarboxylase; D013011:Sorbic Acid