The applicability of an amidated polysaccharide hydrogel as a cartilage substitute: structural and rheological characterization.
An amidic derivative of a carboxymethylcellulose-based hydrogel was obtained and characterized in terms of amidation degree. NMR studies and FT-IR imaging spectroscopy demonstrated that the reaction allowed a polymer to be obtained that was characterized by a regular distribution of amidic groups along the polysaccharide chains. Through this regularity, a homogenous three-dimensional scaffold was obtained, which maintained the thixotropic property of the linear polysaccharide.
Leone
Gemma
G
CRISMA and Department of Chemical and Biosystem Science and Technologies, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Delfini
Maurizio
M
Di Cocco
Maria Enrica
ME
Borioni
Anna
A
Barbucci
Rolando
R
D000577:Amides; D001672:Biocompatible Materials / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium; D002356:Cartilage; D020100:Hydrogels / Q000737:chemistry* / Q000627:therapeutic use; D011134:Polysaccharides / Q000737:chemistry* / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D014783:Viscosity
D000577:Amides; D001672:Biocompatible Materials; D020100:Hydrogels; D011134:Polysaccharides; D002266:Carboxymethylcellulose Sodium