Persistence on treatment and blood pressure control with different first-line antihypertensive treatments: a prospective evaluation.
We enrolled 347 hypertensive patients, randomly allocated them to different first-line treatments, and followed-up for 24 months. Persistence on treatment was significantly higher in patients treated with ARBs (68.5%) and ACE inhibitors (64.5%) vs. CCBs (51.6%), beta-blockers (44.8%), and diuretics (34.4%). No ARB, ACE inhibitor, beta-blocker, or diuretic was associated with a greater persistence in therapy as compared with the other molecules used in each therapeutic class. The rate of persistence was significantly higher in patients treated with lercanidipine vs. other CCBs (59.3% vs. 46.6%). Systolic and diastolic BP decreased more in patients treated with ARBs (-11.2/-5.8 mmHg), ACE inhibitors (-10.5/-5.1 mmHg), and CCBs (-8.5/-4.6 mmHg) when compared to beta-blockers (-4.0/-2.3 mmHg) and diuretics (-2.3/-2.1 mmHg).
D. Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum, University of Bologna, Italy.
Maria Grazia
MG
Prandin
Arrigo F G
AF
Cicero
Maddalena
M
Veronesi
Eugenio
E
Cosentino
Ada
A
Dormi
Enrico
E
Strocchi
Claudio
C
Borghi
D000959:Antihypertensive Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000959:Antihypertensive Agents