Relationship between insulin-like growth factor-I and brain natriuretic peptide in patients with acromegaly after surgery.
BACKGROUND
Increased cardiac insulin-like growth factor (IGF)-I production is associated with physiological cardiac hypertrophy in athletes, and IGF-I has been recognized as a cardioprotective agent in experimental animal studies. On the other hand, acromegaly which is characterized by an excess of IGF-I has been linked to impaired cardiac function.


RESULTS
Both the relationship between the serum levels of IGF-I and brain natriuretic peptide (BNP), which is released from the cardiac ventricles in response to ventricular stress, and that between IGF-I and the concentrations of the plasma amino-terminal propeptide of procollagen type III (P-III-P), which is associated with myocardial fibrosis, were evaluated in 19 patients after surgical treatment for acromegaly. Echocardiography revealed that left ventricular systolic function and dimensions were within normal range in all patients. Significant inverse correlations were found between IGF-I and the BNP (r=-0.5, p=0.02) and P-III-P levels (r=-0.62, p=0.005).


CONCLUSIONS
We observed an inverse significant relationship between IGF-I and both the BNP and P-III-P value in surgically treated acromegaly patients. These observations suggest that appropriate levels of IGF-I have beneficial cardioprotective effects after surgery in patients with acromegaly.
Ito
Masahiro
M
Division of Cardiology, Department of Neurosurgery, Brain Institute, Niigata University School of Medicine, Japan. masaboston2001@yahoo.co.jp
Kodama
Makoto
M
Tsumanuma
Itaru
I
Ramadan
Mahmoud M
MM
Hirayama
Satoshi
S
Kamimura
Takashi
T
Kashimura
Takeshi
T
Fuse
Koichi
K
Hirono
Satoru
S
Okura
Yuji
Y
Aizawa
Yoshifusa
Y
D000172:Acromegaly / Q000097:blood* / Q000601:surgery*; D002316:Cardiotonic Agents / Q000097:blood; D004719:Endomyocardial Fibrosis / Q000097:blood; D005260:Female; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000502:physiology
D002316:Cardiotonic Agents; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D020097:Natriuretic Peptide, Brain; D007334:Insulin-Like Growth Factor I