Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury.
Neutrophil (also known as polymorphonuclear leukocyte, or PMN) transepithelial migration and accumulation at mucosal surfaces is a hallmark of many inflammatory conditions. This process correlates directly with clinical disease activity and epithelial injury. Currently, the mechanisms that define PMN epithelial interactions during an inflammatory response are not completely understood. This review provides an overview of the consequences of PMN infiltration into epithelial tissues and highlights molecular details of PMN epithelial interactions during transmigration. A better understanding of this process will likely provide new insights into developing organ-specific treatment strategies to reduce the deleterious consequences of epithelial inflammation.
Chin
Alex C
AC
Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA. achin@emory.edu
Parkos
Charles A
CA
D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004848:Epithelium / Q000293:injuries / Q000473:pathology / Q000502:physiology; D006801:Humans; D009092:Mucous Membrane / Q000293:injuries / Q000473:pathology / Q000502:physiology; D020556:Neutrophil Infiltration / Q000502:physiology*; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology