A comparative study of treatment for brain edema: magnesium sulphate versus dexamethasone sodium phosphate.
Treatments for brain edema are important and one of the major options is corticosteroids. Cell membrane stabilization and prevention of formation of free radicals are the main mechanisms of action of steroids in edema treatment. As an alternative therapeutic agent, magnesium sulphate has been used for its neuroprotective effect in various injury models. In our animal model of brain injury, cold has been used in Sprague-Dawley rats. After brain injury, magnesium sulphate (600 mg/kg) or dexamethasone sodium phosphate (0.2 mg/kg) were administered to experimental groups. The degree of brain edema and lipid peroxidation was evaluated using the wet-dry weight method, the determination of malondialdehyde (MDA) levels and an ultrastructural grading system. Magnesium sulphate treatment was found to be the most effective choice due to the absence of side effects and comparable efficacy to corticosteroids.
Turkoglu
Omer Faruk
OF
Department of Neurosurgery, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey. ofturkoglu@yahoo.com
Eroglu
Hakan
H
Okutan
Ozerk
O
Tun
M Kagan
MK
Bodur
Ebru
E
Sargon
Mustafa F
MF
Oner
Levent
L
Beskonakli
Etem
E
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D001930:Brain Injuries / Q000150:complications; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004195:Disease Models, Animal; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric
D018696:Neuroprotective Agents; C004180:dexamethasone 21-phosphate; D008278:Magnesium Sulfate; D003907:Dexamethasone