Coordinating cell proliferation and migration in the lens and cornea.
Migration is a complex process for epithelial tissues, because the epithelium must move as an intact sheet to preserve its barrier function. The requirement for structural integrity is met by coupling cell-to-matrix and cell-to-cell adhesion at the cellular level, and by coordinating cell proliferation and cell migration in the tissue as a whole. Proliferation is suppressed at the migrating cell front, allowing cells in this region to remain tightly packed while advancing rapidly. At the same time, proliferation is enhanced in a region behind the advancing cell front to expand the epithelial cell sheet. This review considers the extracellular signals and intracellular signaling pathways that regulate these processes in the lens and corneal epithelium, with emphasis on the commonalities that link these tissues.
Zelenka
P S
PS
National Eye Institute, NIH, Bethesda, MD 20892, USA. pz2b@nih.gov
Arpitha
P
P
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D003315:Cornea / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007908:Lens, Crystalline / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D045726:Metalloproteases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D011493:Protein Kinase C / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D018631:ras Proteins / Q000502:physiology; D019061:src-Family Kinases / Q000502:physiology
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D016718:Arachidonic Acid; D019061:src-Family Kinases; D011493:Protein Kinase C; D048049:Extracellular Signal-Regulated MAP Kinases; D045726:Metalloproteases; D018631:ras Proteins