[Antibiotic properties of the strains of the basidiomycete Lentinus edodes (Berk.) sing].
Antibiotic properties of the extracts from the fermentation broth and mycelium of 15 strains of the edible and medicinal basidiomycete L. edodes were studied and it was shown that the extracts were active against grampositive and gramnegative bacteria, yeasts and mycelial fungi, including dermatophytes and phytopathogens. The strains differed by the set of the organisms susceptible to the action of the extracts. Strains of L. edodes combining marked antibiotic properties and high yields of water soluble polysaccharides were screened. The active compounds were detected by preparative TLC. Two of them were identified with UV- and mass spectrometry as lentinamycin B and erytadenine (lentinacin). Lentinamycin B was found to be the main component responsible for the antibiotic activity of the L. edodes strains.
A Iu
AIu
Soboleva
L M
LM
Krasnopol'skaia
G B
GB
Fedorova
G S
GS
Katrukha
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D017077:Culture Media, Conditioned / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D025282:Mycelium / Q000254:growth & development / Q000378:metabolism; D020942:Shiitake Mushrooms / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D017077:Culture Media, Conditioned