Ligand-free Pd/C-catalyzed Suzuki-Miyaura coupling reaction for the synthesis of heterobiaryl derivatives.
We have developed a mild and efficient protocol for the ligand-free and heterogeneous Pd/C-catalyzed hetero Suzuki-Miyaura coupling reaction that allows for the synthesis of both heteroaryl-aryl and heteroaryl-heteroaryl derivatives in good to excellent yields.
Kitamura
Yoshiaki
Y
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, 502-8585, Japan.
Sako
Satoko
S
Udzu
Takahiro
T
Tsutsui
Azusa
A
Maegawa
Tomohiro
T
Monguchi
Yasunari
Y
Sajiki
Hironao
H
D001897:Boronic Acids / Q000737:chemistry; D001965:Bromides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D001897:Boronic Acids; D001965:Bromides; D008024:Ligands; D010165:Palladium; D002244:Carbon