Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device.
The PediPump is a small ventricular assist device (VAD) with a hydraulic output range designed to support children from newborns to adolescents. The present report describes our initial evaluation of the PediPump as a left VAD in an acute sheep model. The PediPump was implanted in two sheep (50.8 and 62.7 kg). Pump speed was adjusted to achieve a flow of 2 L/min with the naturally occurring preload and afterload conditions to evaluate pump performance under a steady hemodynamic state for 4 hours. Upon completion, pump performance was evaluated under various blood pressure and heart rate conditions. During steady-state evaluations, the ascending aortic flow and pump speed varied slightly depending on systemic arterial pressure variations. During the hemodynamic manipulation studies, flows ranged between 0.5 and 3.2 L/min with pump speeds of 5,200-16,200 rpm and motor current of 0.06-0.75 A. The PediPump demonstrated good initial hemodynamic performance for use as an implantable left VAD. However, some depositions were detected at the time of explanation, mainly at the rear of the pump. We are continuing with further acute studies to evaluate pump performance in anticipation of beginning chronic studies to evaluate long-term biocompatibility.
Saeed
Diyar
D
Department of Biomedical Engineering, Lerner Research Institute, OH, USA.
Weber
Stephan
S
Ootaki
Yoshio
Y
Mielke
Nicole
N
Ootaki
Chiyo
C
Akiyama
Masatoshi
M
Horai
Tetsuya
T
Catanese
Jacquelyn
J
Fumoto
Hideyuki
H
Hideyuki
Fumoto
F
Dessoffy
Raymond
R
Dudzinski
David T
DT
Gu
Lei
L
Casas
Fernando
F
Smith
William A
WA
Fukamachi
Kiyotaka
K
Duncan
Brian W
BW
D000818:Animals; D001698:Biomedical Engineering; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D008280:Magnetics; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D012399:Rotation; D012756:Sheep; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D016277:Ventricular Function, Left
D006454:Hemoglobins; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine