[Adaptive evolution of chemokines and their receptors genes].
Branch-Site Model is a statistical method for detecting molecular adaptation at individual along specific lineages. Not only the model could indicate whether genes in phylogeny under the positive selection or not, but also could forecast positive selection sites in these genes. The sites promote divergence and polymorphism of genes. Chemokines are chemotactic cytokines that can induce immune cells migration, conducting their functions via chemokine receptors. In the test, the molecular adaptation of chemokines and chemokines receptors genes had been analyzed by Branch-Site model. The results showed that only a few of genes, such as RANTES and CCR5, are in the course of positive selection. Several CCR5 positive selection sites are located in a region that involved in binding to receptor and its chemokine.
Tao
Min
M
College of Life Science, Nanchang University, Nanchang 330031, China.
Fan
Tang-Huai
TH
Xu
Li-Zhong
LZ
Hu
Cheng-Yu
CY
D000220:Adaptation, Biological / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D018946:Chemokine CCL5 / Q000737:chemistry / Q000235:genetics; D018925:Chemokines / Q000737:chemistry / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011487:Protein Conformation; D019713:Receptors, CCR5 / Q000737:chemistry / Q000235:genetics; D019707:Receptors, Chemokine / Q000737:chemistry / Q000235:genetics*; D012641:Selection, Genetic; D049490:Systems Biology
D018946:Chemokine CCL5; D018925:Chemokines; D019713:Receptors, CCR5; D019707:Receptors, Chemokine