Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.
Department of Surgery, Davis Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, OH, USA.
Mordhwaj S
MS
Parihar
Rafal R
RR
Nazarewicz
Erick
E
Kincaid
Urs
U
Bringold
Pedram
P
Ghafourifar
D000818:Animals; D002478:Cells, Cultured; D042967:Electron Transport Complex I / Q000378:metabolism*; D004789:Enzyme Activation; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*; D013223:Statistics as Topic
D024101:Mitochondrial Proteins; D019001:Nitric Oxide Synthase; D042967:Electron Transport Complex I