Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.
OBJECTIVE
The role of SLC19A1 -43T>C, MTHFR 677C>T and MS 2756A>G polymorphisms on red cell and plasma folate levels.


METHODS
Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease.


RESULTS
The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.


CONCLUSIONS
SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.
Department of Obstetrics and Gynecology, Ioannina University School of Medicine, Ioannina, 45110, Greece.
Anthoula
A
Chatzikyriakidou
Konstantinos V
KV
Vakalis
Nicholas
N
Kolaitis
Georgios
G
Kolios
Katerina K
KK
Naka
Lampros K
LK
Michalis
Ioannis
I
Georgiou
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000097:blood* / Q000235:genetics; D005494:Folic Acid Deficiency / Q000097:blood / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058978:Reduced Folate Carrier Protein; D044967:Serum / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D026901:Membrane Transport Proteins; D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase