The left heart can only be as good as the right heart: determinants of function and dysfunction of the right ventricle.
Discussions of cardiac physiology and pathophysiology most often emphasise the function of the left heart. However, right heart dysfunction plays an important role in critically ill patients and is often not recognised. This is probably because the role of the right ventricle is for generating flow more than pressure, and flow is not easy to evaluate. Of importance, when right ventricular function limits cardiac output, assessing left ventricular function gives little indication of overall cardiac performance. It has recently become evident that the right ventricle also has different genetic origins and characteristics from the left ventricle. The right and left ventricles interact through series effects, diastolic interactions and systolic interactions. The mechanisms of these, and their physiological and pathological significance are discussed.
Division of Critical Care Medicine, McGill University Health Centre, Montreal, Quebec, Canada. sheldon.magder@muhc.mcgill.ca
Sheldon
S
Magder
D000818:Animals; D002302:Cardiac Output / Q000502:physiology; D004548:Elasticity; D022062:Electrophysiologic Techniques, Cardiac; D006334:Heart Function Tests; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology