Inflammation and oxidative stress in obstructive sleep apnea syndrome.
Similar to obesity, with which it is closely associated, obstructive sleep apnea syndrome (OSAS) is rapidly becoming a worldwide epidemic. Current knowledge of its pathogenesis has been significantly enriched by numerous experimental studies that have demonstrated an important role of oxidative stress and inflammation. Furthermore, new and exciting data strongly connect these two components in the perpetuation of the condition via the overexpression of nuclear factor kappaB. Experimental data support the hypothesis that nutrition might represent a promising future approach with antioxidants currently being good candidates for the modulation of cardiovascular sequelae, although weight reduction and controlled positive airway pressure remain the only established treatments for OSAS. We discuss herein the recent literature that illustrates these new paradigms and speculate on possible implications and future scenarios.
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA.
Carlo
C
Selmi
Nicola
N
Montano
Raffaello
R
Furlan
Carl L
CL
Keen
M Eric
ME
Gershwin
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy; D016328:NF-kappa B / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D015431:Weight Loss
D000975:Antioxidants; D016328:NF-kappa B