[Sonopermeabilization: therapeutic alternative with ultrasound and microbubbles].
Future applications of ultrasound and microbubbles extend to more than imaging applications. Over the last few years, it was reported that sonographic contrast agent effects under ultrasound, modulate transiently cell membrane permeability. This process, named sonoporation and classified as a new physical method to transfer genes or drugs, consists of using a physical energy source to modulate membrane integrity. The possibility to transfer therapeutic genes would be a new tool for gene therapy and could constitute an alternative method. After in vitro and in vivo studies presentation, the therapeutic potential of sonoporation will be investigated in this paper.
Unité Inserm 619, Hôpital Bretonneau, CHU Tours, Université François Rabelais, 2 boulevard Tonnellé, 37044 Tours cedex, France.
K
K
Kaddur
P
P
Palanchon
F
F
Tranquart
C
C
Pichon
A
A
Bouakaz
D002463:Cell Membrane Permeability; D003584:Cytological Techniques; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D045423:Microbubbles; D014465:Ultrasonics