Do women express and experience psychosis differently from men? Epidemiological evidence from the Australian National Study of Low Prevalence (Psychotic) Disorders.
OBJECTIVE
To examine how women differ from men in their expression and experience of psychosis.


METHODS
Using an epidemiological sampling frame, 1090 cases of psychosis (schizophrenia, schizoaffective disorder, affective psychoses, and other psychoses) were randomly selected from a catchment of 1.1 million people as part of the Australian Study of Low Prevalence (Psychotic) Disorders. Women and men were compared with respect to their premorbid functioning, onset and course of illness, symptomatology, levels of disability and service utilization.


RESULTS
Results within diagnostic groupings confirm differences in how men and women experience and express their illness. Within each diagnostic group, women reported better premorbid functioning, a more benign illness course, lower levels of disability and better integration into the community than men. They were also less likely to have a chronic course of illness. There were no significant differences in age at onset. Differences between women across the diagnostic groups were more pronounced than differences between women and men within a diagnostic group. In particular, women with schizophrenia were severely disabled compared to other women.


CONCLUSIONS
These comparisons across diagnostic groupings are among the most systematic and comprehensive in the literature. It is likely that several mechanisms are needed to explain the differences. Greater social integration and functioning in women across diagnostic groups may well reflect culturally and socially determined gender differences. In contrast, variability and attenuated findings with respect to symptom profiles beg the question of biological mechanisms with some degree of specificity.
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia. vmorgan@cyllene.uwa.edu.au
Vera A
VA
Morgan
David J
DJ
Castle
Assen V
AV
Jablensky
D000328:Adult; D017668:Age of Onset; D001315:Australia; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D005783:Gender Identity; D006306:Health Surveys; D006801:Humans; D008297:Male; D008605:Mental Health Services / Q000706:statistics & numerical data; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology; D012917:Social Adjustment; D016896:Treatment Outcome; D014600:Utilization Review / Q000706:statistics & numerical data