Dectin-1 is not required for the host defense to Cryptococcus neoformans.
Dectin-1 is known as a sole receptor for beta-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.
Nakamura
Kiwamu
K
Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Kinjo
Takeshi
T
Saijo
Shinobu
S
Miyazato
Akiko
A
Adachi
Yoshiyuki
Y
Ohno
Naohito
N
Fujita
Jiro
J
Kaku
Mitsuo
M
Iwakura
Yoichiro
Y
Kawakami
Kazuyoshi
K
D000818:Animals; D003453:Cryptococcosis / Q000276:immunology / Q000517:prevention & control*; D003455:Cryptococcus neoformans / Q000276:immunology / Q000472:pathogenicity*; D003713:Dendritic Cells / Q000276:immunology; D017353:Gene Deletion; D018664:Interleukin-12 / Q000096:biosynthesis*; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000099181:Dectin-1
D018664:Interleukin-12; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000099181:Dectin-1