Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.
Among industrialized countries, the rate of drug-induced liver failure varies widely accounting for about 1-12% of the indications for liver transplantation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are with antibiotics the most frequently involved compounds. In this single-center series of 57 consecutive cases of acute liver failure treated by orthotopic liver transplantation, five were related to NSAIDs-induced liver damage, three being due to nimesulide use. This has to be taken as a further warning about the potential for this compound to induce liver failure.
Department of Gastroenterology and Hepatology, St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
Sergio Negrin
SN
Dastis
Jacques
J
Rahier
Jan
J
Lerut
André P
AP
Geubel
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000601:surgery; D016031:Liver Transplantation; D008875:Middle Aged; D010894:Piroxicam / Q000009:adverse effects; D011720:Pyrazoles / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D010894:Piroxicam; D000068579:Celecoxib; C012655:nimesulide