C. elegans and volatile anesthetics.
The mechanism of action of volatile anesthetics remains an enigma, despite their worldwide use. The nematode C. elegans has served as an excellent model to unravel this mystery. Genes and gene sets that control the behavior of the animal in volatile anesthetics have been identified, using multiple endpoints to mimic the phenomenon of anesthesia in man. Some of these studies have clear translational implications in more complicated organisms.
Morgan
P G
PG
Department of Anesthesiology, Case School of Medicine, Cleveland, OH 44106, USA.
Kayser
E-B
EB
Sedensky
M M
MM
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007103:Immobilization; D008928:Mitochondria / Q000187:drug effects
D000777:Anesthetics