Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity.
The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.
Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.
Kyoko
K
Suzuki
Mamoru
M
Okasaka
Yoshiki
Y
Kashiwada
Yoshihisa
Y
Takaishi
Gisho
G
Honda
Michiho
M
Ito
Yoshio
Y
Takeda
Olimjon K
OK
Kodzhimatov
Ozodbek
O
Ashurmetov
Michiko
M
Sekiya
Yasumasa
Y
Ikeshiro
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003078:Colchicine / Q000032:analysis / Q000493:pharmacokinetics; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005309:Ferula / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014610:Uzbekistan
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; D003078:Colchicine