T-helper (Th)1/Th2 imbalance in the peripheral blood of dogs with malignant tumor.
T helper type 1 cell (Th1)/Th2 imbalance has been observed in a variety of pathological conditions, including malignant diseases. We evaluated the Th1/Th2 in peripheral blood Th cells by means of intracytoplasmic cytokine analysis in 11 dogs with advanced malignant tumor; four of them showed metastatic tumor. The percentage of Th1 was significantly lower and the percentage of Th2 was significantly higher in diseased dogs compared to healthy dogs. The percentage of Th1 in three patients with metastatic tumor was significantly lower than that in the patients with non-metastatic tumor. We conclude that the Th1/Th2 balance was polarized to Th2 in dogs with cancer.
Department of Veterinary Radiology, College of Bioresource Sciences, Nihon University, Kanagawa, Japan. gr86514h@st.brs.nihon-u.ac.jp
Yutaka
Y
Horiuchi
Asami
A
Hanazawa
Yuko
Y
Nakajima
Yoko
Y
Nariai
Hideki
H
Asanuma
Masato
M
Kuwabara
Masayoshi
M
Yukawa
Hiroshi
H
Ito
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D004285:Dogs; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology