Effect of human bone marrow stromal cells and dermal fibroblasts on collagen synthesis and epithelization.
In a previous in vitro study, the authors reported that bone marrow stromal cells (BSCs) have better wound-healing activities than fibroblasts. The purpose of this study was to evaluate the effect of BSCs and fibroblasts on wound-healing activity in vivo. Cultured human BSCs and dermal fibroblasts taken from the same patients were tested to compare collagen synthesis and epithelization in a rat wound model. No-cell-treated animals were used as controls. The BSC group showed the highest collagen level, followed by the fibroblast group, and then the no-cell group (P < 0.05). In addition, the best epithelization was observed in the BSC group. These results demonstrate that BSCs better stimulate wound healing than fibroblasts in vivo and in vitro.
Department of Plastic Surgery, Kangwon National University College of Medicine, Choonchun Korea.
Chi-Ho
CH
Lee
Seung-Kyu
SK
Han
Won-Il
WI
Choi
Woo-Kyung
WK
Kim
D000328:Adult; D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D003094:Collagen / Q000096:biosynthesis*; D020405:Dermis / Q000166:cytology* / Q000378:metabolism*; D004848:Epithelium / Q000254:growth & development*; D005347:Fibroblasts / Q000378:metabolism* / Q000637:transplantation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D017154:Stromal Cells / Q000637:transplantation*
D003094:Collagen