Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering.
Genetic System Regulation Laboratory, RIKEN Discovery Research Institute, 2-1 Hirosawa, Wako-shi, Saitama-ken 351-0198, Japan.
Hidetaka
H
Seo
Takatomi
T
Yamada
Shu-ichi
S
Hashimoto
Waka
W
Lin
Kunihiro
K
Ohta
D000107:Acetylation; D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000378:metabolism; D000916:Antibody Diversity / Q000187:drug effects / Q000235:genetics; D002460:Cell Line; D002645:Chickens / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D005785:Gene Conversion; D005803:Genes, Immunoglobulin; D006657:Histones / Q000378:metabolism; D006877:Hydroxamic Acids / Q000494:pharmacology; D015202:Protein Engineering / Q000379:methods; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D000911:Antibodies, Monoclonal; D006657:Histones; D006877:Hydroxamic Acids; C012589:trichostatin A