The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits.
In the present study, the efficiency of the administration of doramectin (DOR) and DOR+vitamin AD3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200 microg/kg) and DOR (200 microg/kg)+VIT AD3E were administered to infested rabbits intramuscularly (IM). The administration of DOR and DOR+VIT improved the healing of ear lesions on day seven. Increase in the plasma malondialdehyde (MDA) level and erythrocyte catalase (CAT) activity, and decrease in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in infested rabbits. In the rabbits which were administered DOR+VIT, plasma MDA levels decreased, and erythrocyte GSH-Px and SOD activities increased on day seven. In conclusion, DOR and DOR+VIT combination were effective against P. cunuculi infestation. Infestation stimulated oxidative stress. VIT treatment resulted in antioxidant activity against oxidative stress induced by P. cuniculi infestation.
Department of Pharmacology and Toxicology, Faculty of Veterinary, University of Erciyes, Kayseri, Turkey. kanburm@hotmail.com
Murat
M
Kanbur
Oznur
O
Atalay
Anil
A
Ica
Gokhan
G
Eraslan
Yucel
Y
Cam
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D040042:Psoroptidae / Q000187:drug effects; D011817:Rabbits; D014815:Vitamins / Q000008:administration & dosage* / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D007306:Insecticides; D014815:Vitamins; D007559:Ivermectin; C084101:doramectin