Refractory ulcerative colitis and iatrogenic colorectal Kaposi's sarcoma.
Colorectal Kaposi's sarcoma, a human herpes virus-8 associated mesenchymal tumour, is exceedingly rare in human immunodeficiency virus-negative subjects and almost always reported in association with severe, refractory, inflammatory bowel disease. In this paper we report a case--the second from Italy--of a colorectal Kaposi's sarcoma in a human immunodeficiency virus-negative, heterosexual man with severe refractory ulcerative colitis. Kaposi's sarcoma developed after starting glucocorticosteroid therapy, supporting the theory that colorectal Kaposi's sarcoma associated with ulcerative colitis is iatrogenic.
First Division of Internal Medicine, Service of Gastroenterology and Digestive Endoscopy, Hospital of Busto Arsizio, Italy. cargirel@libero.it
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Girelli
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Rocca
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D000328:Adult; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003106:Colon / Q000473:pathology / Q000601:surgery; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D016572:Cyclosporine / Q000009:adverse effects; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D011241:Prednisone / Q000009:adverse effects; D012514:Sarcoma, Kaposi / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011241:Prednisone