On the chemical constituents of Dipsacus asper.
Bioassay-guided fractionation of 95% EtOH extract from the roots of Dipsacus asper lead to the isolation of some phenolic acids (caffeic acid, 2,6-dihydroxycinnamic acid, vanillic acid, 2'-O-caffeoyl-D-glucopyranoside ester, and caffeoylquinic acid) as the major active components, and five new iridoid glucoside dimers (1-5) and one new iridoid glucoside monomer (6), other known iridoid glycosides loganin, cantleyoside, triplostoside A, lisianthioside, 6'-O-beta-D-apiofuranosyl sweroside, as well as triterpenoids oleanic acid and akebiasaponin D. The structures of new compounds 1-6 were determined as dipsanosides C (1), D (2), E (3), F (4), G (5), and 3'-O-beta-D-glucopyranosyl sweroside (6) by spectroscopic, including 1D and 2D NMR techniques, and chemical methods.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Peking Union Medicinal College and Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
Xiao-Yan
XY
Tian
Ying-Hong
YH
Wang
Hong-Yue
HY
Liu
Shi-Shan
SS
Yu
Wei-Shuo
WS
Fang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001681:Biological Assay; D002241:Carbohydrates / Q000032:analysis; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D049917:Dipsacaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D011208:Powders; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D002241:Carbohydrates; D062385:Hydroxybenzoates; D039823:Iridoids; D011208:Powders; C017616:phenolic acid