Posterior error probabilities and false discovery rates: two sides of the same coin.
A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.
Käll
Lukas
L
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Storey
John D
JD
MacCoss
Michael J
MJ
Noble
William Stafford
WS
D000465:Algorithms; D030562:Databases, Protein; D015233:Models, Statistical; D010455:Peptides / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D010455:Peptides