Preimplantation genetic screening to improve in vitro fertilization pregnancy rates: a prospective randomized controlled trial.
This prospective randomized controlled pilot trial was designed to evaluate whether prescreening embryos for aneuploidy can improve clinical outcomes in infertile patients undergoing IVF, without limiting to poor prognosis patients. Although there was no statistically significant improvement in live birth rates or implantation rates in this pilot study, there was a trend toward improved clinical outcomes, indicating that future multicenter randomized trials are needed.
Mersereau
Jennifer E
JE
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of California, San Francisco, California, USA.
Pergament
Eugene
E
Zhang
Xingqi
X
Milad
Magdy P
MP
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000453:epidemiology* / Q000628:therapy*; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D019836:Preimplantation Diagnosis / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies; D016896:Treatment Outcome