Is tumor necrosis factor-376A promoter polymorphism associated with susceptibility to multiple sclerosis?
A single nucleotide polymorphism (SNP) at position -376 of the tumor necrosis factor alpha gene (TNFA) has been associated with susceptibility to multiple sclerosis (MS) in Spain. However, no association was found in populations from the USA and The Netherlands. Here we investigate the association between the TNFA-376A SNP and MS susceptibility in Argentinean patients with MS. The A/G genotype was found in 4.4% of patients (n=90) and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23-3.84). Thus, no significant differences in genotype and allele frequencies were found between healthy individuals and patients with MS in Argentina.
División Neurologia, Hospital J.M. Ramos Mejía, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Marcelo A
MA
Kauffman
Dolores González
DG
Morón
Gustavo
G
Sandoval
Roberto E
RE
Sica
Orlando
O
Garcea
Andrés M
AM
Villa
D000483:Alleles; D001118:Argentina; D004812:Epidemiologic Methods; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013030:Spain / Q000208:ethnology; D048069:Tumor Necrosis Factors / Q000235:genetics*
D048069:Tumor Necrosis Factors