Cartilage tissue engineering using resorbable scaffolds.
Cartilage tissue engineering holds considerable promise for orthopaedic and reconstructive head and neck surgery. With an increasingly ageing population, the number of patients affected by arthritis and recurrent joint pain is constantly growing, along with the associated socio-economic costs. In head and neck surgery reconstructive procedures gain increasing importance in multimodal tumour therapies. These procedures require the harvesting of large amounts of donor tissue, which causes significant donor site morbidity. Therefore, in vitro-engineered cartilage may provide for a cost-effective and clinically valuable medical need. This article presents an overview of the clinical background as well as considerations for engineered cartilage in the head and neck, and provides examples of cartilage tissue engineering based on various scaffolds.
Rotter
Nicole
N
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Schleswig-Holstein, Campus Lübeck, Germany. nicole.rotter@hno.uniluebeck.de
Bücheler
Markus
M
Haisch
Andreas
A
Wollenberg
Barbara
B
Lang
Stephan
S
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D002356:Cartilage; D002357:Cartilage Diseases / Q000628:therapy; D018929:Cell Culture Techniques; D006801:Humans; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds
D001672:Biocompatible Materials