Cerebrovascular accident during cisplatin-based combination chemotherapy of testicular germ cell tumor: an unusual case report.
Even though testicular nonseminomatous germ cell tumors (NSGCTs) usually have a good prognosis and high curability rates, unpredicted complications owing to chemotherapy regimens might complicate the course. Modalities that are commonly used to cure NSGCTs have well-known side effects. Thromboembolism, which is infrequently associated with germ cell tumors and the vascular toxicity of chemotherapeutics, causes morbidity and mortality. We report a young testicular NSGCT patient, without any known underlying risk factor, who experienced an unpredicted cerebrovascular accident after he received cisplatin-based combination chemotherapy.
Department of Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey. aprazak@yahoo.com
Alper
A
Azak
Berna
B
Oksüzoğlu
Tağmaç
T
Deren
Birgül Müftüoğlu
BM
Oneç
Nurullah
N
Zengin
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D002544:Cerebral Infarction / Q000139:chemically induced / Q000209:etiology; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000188:drug therapy; D020521:Stroke / Q000139:chemically induced / Q000209:etiology*; D013736:Testicular Neoplasms / Q000150:complications* / Q000188:drug therapy; D013923:Thromboembolism / Q000139:chemically induced / Q000209:etiology; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D002945:Cisplatin