Low-fluoride dentifrice and caries lesion control in children with different caries experience: a randomized clinical trial.
Since there is no consensus on the anticaries effectiveness of low-fluoride (F) dentifrice, this randomized clinical trial evaluated its effect in children at different caries activity status. One hundred and twenty 2- to 4-year-old children, half with and half without active caries lesions, were randomly divided into 2 groups which used 500- or 1,100-microg F/g (NaF) dentifrices during 1 year. Caries progression or regression were evaluated as the number of lesions becoming active/cavities or inactive, respectively. The anticaries effect of the low-F dentifrice was similar to the conventional F dentifrice when used by caries-inactive children. However, in children with active caries lesions the low-F dentifrice was less effective than the 1,100-microg F/g dentifrice in controlling the progression of lesions. The data suggest that the child caries activity may be taken into account to recommend a low-F dentifrice.
Lima
T J
TJ
Faculty of Dentistry, Federal University of Maranhão, UFMA, São Luís, Brazil.
Ribeiro
C C C
CC
Tenuta
L M A
LM
Cury
J A
JA
D002327:Cariostatic Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000188:drug therapy* / Q000473:pathology; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000008:administration & dosage*
D002327:Cariostatic Agents; D003802:Dentifrices; D012969:Sodium Fluoride