Pregnancy outcomes in women using inhaled fluticasone during pregnancy: a case series.
BACKGROUND
The aim of the study was to report the maternal and fetal outcomes of women with respiratory illnesses who were treated with inhaled fluticasone during pregnancy.


METHODS
We identified 12 cases treated with inhaled fluticasone during pregnancy out of women who received obstetric and teratogen-risk evaluation at the Korean Motherisk Program. A detailed medical and obstetric history was obtained and cases were followed-up until either spontaneous or voluntary pregnancy termination or delivery occurred.


RESULTS
None of the participants had any obstetric complication. However, in addition to fluticasone, most of the 12 cases were simultaneously exposed to a variety of medications. There were 3 abortions (one spontaneous and 2 requested by the patients arguing personal reasons). Live born babies without any evidence of major congenital malformations included 8 singleton babies and 2 twins. Of them, 3 babies were born prematurely.


CONCLUSIONS
Our results are in agreement with previous large studies where no increased rate of adverse outcomes was reported with the use of inhaled corticosteroids during pregnancy.
Choi
J S
JS
The Korean Motherisk Program. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Cheil General Hospital and Women's Healthcare Center. Kwandong University College of Medicine. Seoul. Korea.
Han
J Y
JY
Kim
M Y
MY
Velázquez-Armenta
E Y
EY
Nava-Ocampo
A A
AA
D000280:Administration, Inhalation; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D000068298:Fluticasone; D006801:Humans; D007223:Infant; D007723:Korea; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000276:immunology*; D011256:Pregnancy Outcome; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology
D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000068298:Fluticasone