Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties.
The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.
Department of Integrative Biology and Computer Science, Brigham Young University, 3370 TMCB, Provo, Utah 84602, USA. marktwe@byu.net
Mark T W
MT
Ebbert
Wesley A
WA
Beckstead
Timothy D
TD
O'Connor
Mark J
MJ
Clement
David A
DA
McClellan
D000596:Amino Acids / Q000737:chemistry*; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000502:physiology*; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000737:chemistry
D000596:Amino Acids; D011506:Proteins; D019389:Cytochrome P-450 CYP2D6