Psoriasis is associated with increased beta-defensin genomic copy number.
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
Hollox
Edward J
EJ
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
Huffmeier
Ulrike
U
Zeeuwen
Patrick L J M
PL
Palla
Raquel
R
Lascorz
Jesús
J
Rodijk-Olthuis
Diana
D
van de Kerkhof
Peter C M
PC
Traupe
Heiko
H
de Jongh
Gys
G
den Heijer
Martin
M
Reis
André
A
Armour
John A L
JA
Schalkwijk
Joost
J
D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
C106641:DEFB4A protein, human; D023083:beta-Defensins