Privileged structures: a useful concept for the rational design of new lead drug candidates.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
Laboratório de Avaliação e Síntese de Substâncias Bioativas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, P.O. Box 68023, ZIP 21944-971, Rio de Janeiro, RJ, Brazil.
Carolina D
CD
Duarte
Eliezer J
EJ
Barreiro
Carlos A M
CA
Fraga
D000818:Animals; D001569:Benzodiazepines / Q000737:chemistry; D004095:Dihydropyridines / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D006835:Hydrazones / Q000737:chemistry* / Q000145:classification; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011724:Pyridazines / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000187:drug effects; D013141:Spiro Compounds / Q000737:chemistry; D013329:Structure-Activity Relationship; D009626:Terminology as Topic
D004095:Dihydropyridines; D006835:Hydrazones; D004364:Pharmaceutical Preparations; D011724:Pyridazines; D011956:Receptors, Cell Surface; D013141:Spiro Compounds; C513630:aminopyridazine; D001569:Benzodiazepines