Familial clustering of migraine, episodic vertigo, and Ménière's disease.
OBJECTIVE
To evaluate the association between migraine, episodic vertigo, and Ménière's disease in families.


METHODS
Clinical report.


METHODS
University Neurotology Clinic.


METHODS
Index patients identified with Ménière's disease and migraine and their family members.


METHODS
Structured interview to assess a diagnosis of migraine, episodic vertigo, and Ménière's disease in 6 families. Genotyping was performed on 3 sets of twins to analyze monozygosity or dizygosity.


METHODS
Clinical history of migraine, episodic vertigo, and Ménière's disease.


RESULTS
Six index patients and 57 family members were interviewed either by a senior neurologist in person or over the phone by a trained study coordinator. An additional 6 family members completed questionnaires by mail. All 6 index patients had Ménière's disease and migraine. Twenty-six (41%) of the 63 relatives met International Classification of Headache Disorders II criteria for migraine headaches. Thirteen (50%) of these 26 experienced migraine with aura. Three others experienced typical aura without headache. Seventeen (27%) of 63 family members experienced recurrent spells of spontaneous episodic vertigo. There was one twin pair in each of 3 families; 2 pairs were monozygotic and one was dizygotic. In each twin pair, one twin had migraine and Ménière's disease, whereas the other experienced migraine and episodic vertigo without auditory symptoms.


CONCLUSIONS
The frequent association of episodic vertigo, migraine, and Ménière's disease in closely related individuals, including identical twins supports the heritability of a migraine-Ménière's syndrome, with variable expression of the individual features of hearing loss, episodic vertigo, and migraine headaches.
Cha
Yoon-Hee
YH
Department of Neurology, University of California-Los Angeles, Los Angeles, California 90095, USA. yhcha@mednet.ucla.edu
Kane
Michael J
MJ
Baloh
Robert W
RW
D000328:Adult; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D034381:Hearing Loss / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D020325:Migraine with Aura / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D010375:Pedigree; D014717:Vertigo / Q000150:complications* / Q000235:genetics / Q000503:physiopathology