Sub-aponeurotic fluid collections: a delayed-onset self-limiting cerebrospinal fluid fistula in young infants.
BACKGROUND
Transient sub-aponeurotic fluid collections are rarely recognized lesions that may be frequently related to traumatic labor and occur within weeks after birth. Their etiology has remained uncertain.


RESULTS
Here we report on five new cases with typical clinical findings and normal neuroimaging. A detailed analysis of the lesion aspirates was performed in three patients, always revealing beta(2)-transferrin and high concentrations of beta-trace protein.


CONCLUSIONS
This indicates that cerebrospinal fluid leakage contributes to this rare condition. All lesions disappeared spontaneously within 2-5 months so that conservative treatment seems appropriate.
Department of Pediatrics, RWTH, University Hospital Aachen, Pauwelsstrasse 30, Aachen, Germany.
Anne
A
Schoberer
Eray
E
Yagmur
Eugen
E
Boltshauser
Marcus
M
Korinth
Pascal
P
Niggemann
Martin
M
Häusler
D017668:Age of Onset; D001720:Birth Injuries / Q000000981:diagnostic imaging / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005260:Female; D005402:Fistula / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007223:Infant; D019746:Intramolecular Oxidoreductases / Q000032:analysis / Q000378:metabolism; D054834:Lipocalins / Q000032:analysis / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D012535:Scalp / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000473:pathology*; D013346:Subarachnoid Space / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014168:Transferrin / Q000032:analysis / Q000378:metabolism; D014463:Ultrasonography
D054834:Lipocalins; D014168:Transferrin; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase