Effects of Microdesmis keayana roots on sexual behavior of male rats.
In the present study, the aphrodisiac properties of Microdesmis keayana J. Léonard root extract and major isolated alkaloids were evaluated by observing the sexual behavior of male rats. Aqueous extract (150mg/kg body weight) and pure alkaloids (3mg/kg body weight) were administered orally by gavage to male rats. Latent times of observation, intromission and ejaculation, mounting behavior, number of intromissions and mating performances were evaluated and compared to those obtained with untreated rats in the presence of receptive and non-receptive females. The results have shown that aqueous extract and alkaloids of M. keayana stimulate sexual parameters in rats' sexual behavior. A short-term toxicity study undertaken to establish the therapeutic index of aqueous extract, showed that a high dose of the extract (2g/kg body weight) caused no mortality or changes in rats' behavior.
Laboratoire de Pharmacognosie (E.A. 1043), Faculté de Pharmacie, Université de Lille 2, B.P. 83, 59006 Lille Cedex, France.
A
A
Zamblé
S
S
Sahpaz
C
C
Brunet
F
F
Bailleul
D000818:Animals; D001046:Aphrodisiacs / Q000737:chemistry / Q000494:pharmacology*; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013095:Spermidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D001046:Aphrodisiacs; C518724:CML-1 plant extract; D003373:Coumaric Acids; D010936:Plant Extracts; C532651:kearanine; C532650:keayanidine B; D013096:Spermine; D013095:Spermidine