A case-control study of the HER2 Ile655Val polymorphism and risk of breast cancer in Taiwan.
OBJECTIVE
To investigate the HER2 Ile655Val polymorphism in relation to risk of breast cancer in a case-control study in Taiwan.


METHODS
The HER2 polymorphism at codon 655 was analyzed in 424 patients with breast cancer and 318 controls by using the polymerase chain reaction methodology, followed by the restriction fragment-length polymorphism (PCR-RFLP) analysis.


RESULTS
There was a 1.48-fold (95% CI=1.00-2.24) increase in the risk of patients with breast cancer who are Val carrier (Ile/Val and Val/Val genotypes). Furthermore, for the early onset (less than 45 years old) breast cancers with Val carrier, there was a 2.24-fold (95% CI=1.17-4.34) increase in the risk of breast cancer.


CONCLUSIONS
Our results indicate that the Val carrier was associated with increased risks in patients with breast cancer in Taiwan. The association was more apparent in patients who were younger than or equal to 45 years of age.
Department of Clinical Laboratory, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Su-Chen
SC
Lee
Ming-Feng
MF
Hou
Pei-Chen
PC
Hsieh
Szu-Hsien
SH
Wu
Linda Ann
LA
Hou
Hsu
H
Ma
Shin-Meng
SM
Tsai
Li-Yu
LY
Tsai
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D014633:Valine / Q000235:genetics
D007532:Isoleucine; D014633:Valine