Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency.
We report a CD40 ligand deficiency (CD40LD) patient who was successfully treated with unrelated cord blood transplantation (URCBT). Conditioning regimen was busulfan and cyclophosphamide. The clinical course was uneventful and durable engraftment was achieved. This successful case encourages the use of URCB as an alternative donor source for CD40LD patients.
Department of Pediatrics, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan. ytsuji@ndmc.ac.jp
Yoichiro
Y
Tsuji
Kohsuke
K
Imai
Yoichi
Y
Morinishi
Kazuhiro
K
Kogawa
Masaaki
M
Morino
Shigeaki
S
Nonoyama
D000361:Agammaglobulinemia / Q000235:genetics / Q000628:therapy*; D002066:Busulfan / Q000008:administration & dosage; D019013:CD40 Antigens / Q000172:deficiency*; D036101:Cord Blood Stem Cell Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D007223:Infant; D019520:Living Donors; D008297:Male; D009503:Neutropenia / Q000235:genetics / Q000628:therapy*; D019172:Transplantation Conditioning
D019013:CD40 Antigens; D003520:Cyclophosphamide; D002066:Busulfan