Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis.
The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-surface protein level, there were significant elevated levels of PD-1 on T cells and its ligand PD-L1 on monocytes in the patients compared to controls. However, we could not demonstrate any secreted soluble forms of PD-1 among the patients and controls. Thus, our study shows PD-1 might have a natural regulatory property behind MG.
Rheumatology Unit, Center for Molecular Medicine L8:04, Karolinska Institutet, Solna, Stockholm, Sweden. priya.sakthivel@ki.se
Priya
P
Sakthivel
Ryan
R
Ramanujam
Xiong Biao
XB
Wang
Ritva
R
Pirskanen
Ann Kari
AK
Lefvert
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000209:etiology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D061026:Programmed Cell Death 1 Receptor; D012333:RNA, Messenger / Q000032:analysis
D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D012333:RNA, Messenger