Synthesis of the benzo-fused indolizidine alkaloid mimics.
A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation.
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. Daniel_Comins@ncsu.edu
Daniel L
DL
Comins
Kazuhiro
K
Higuchi