Carboranyl thymidine analogues for neutron capture therapy.
Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. tjarks.1@osu.edu
Werner
W
Tjarks
Rohit
R
Tiwari
Youngjoo
Y
Byun
Sureshbabu
S
Narayanasamy
Rolf F
RF
Barth
D000818:Animals; D001895:Boron / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry* / Q000627:therapeutic use*; D004194:Disease; D006801:Humans; D017247:Neutron Capture Therapy; D010770:Phosphotransferases / Q000378:metabolism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*
D001896:Boron Compounds; D010770:Phosphotransferases; D001895:Boron; D013936:Thymidine