Imaging obesity: fMRI, food reward, and feeding.
Animal studies have revealed brain regions that control homeostatic feeding, but the rampant overeating contributing to the obesity epidemic suggests the participation of "nonhomeostatic" control centers. Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions.
Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. grill@psych.upenn.edu
Harvey J
HJ
Grill
Karolina P
KP
Skibicka
Matthew R
MR
Hayes
D000818:Animals; D001921:Brain / Q000502:physiology; D004435:Eating / Q000502:physiology; D005502:Food; D006706:Homeostasis; D006801:Humans; D020738:Leptin / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D009765:Obesity / Q000503:physiopathology* / Q000523:psychology; D010446:Peptide Fragments; D019894:Peptide YY / Q000502:physiology; D012201:Reward
D020738:Leptin; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)