Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive) and conventional SLA titanium implants: an immunohistochemical study in dogs.
OBJECTIVE
The aim of the present study was to evaluate bone regeneration in dehiscence-type defects at non-submerged and submerged titanium implants with chemically modified (mod) and conventional sandblasted/acid-etched (SLA) surfaces.


METHODS
Standardized buccal dehiscence defects were surgically created following implant site preparation in both the upper and lower jaws of 12 beagle dogs. Both types of implants were randomly assigned to either a non-submerged or a submerged healing procedure. After 1, 2, 4, and 8 weeks, dissected blocks were processed for histomorphometrical [e.g. new bone height (NBH), per cent linear fill (PLF), percentage of bone to implant contact (BIC-D), area of new bone fill (BF)] and immunohistochemical analysis.


RESULTS
At 8 weeks, non-submerged and submerged SLA implants revealed significantly lower mean NBH (1.1+/-0.8-1.9+/-1.2 mm), PLF (27.7+/-20.3-46.0+/-28.5%), BIC-D (26.8+/-10.4-46.2+/-16.2%), and BF (1.3+/-0.9-3.4+/-2.8 mm(2)) values than respective modSLA implants [NBH (2.6+/-0.8-4.3+/-0.1 mm), PLF (64.2+/-19.4-107.2+/-4.7%), BIC-D (67.5+/-18.8-82.1+/-14.8%), BF (2.9+/-1.0-6.7+/-1.1 mm(2))]. Within modSLA groups, significantly highest BF values were observed at submerged implants.


CONCLUSIONS
It was concluded that (i) modSLA titanium surfaces promoted bone regeneration in acute-type buccal dehiscence defects and (ii) a submerged healing procedure improved the outcome of healing additionally.
Schwarz
Frank
F
Department of Oral Surgery, Westdeutsche Kieferklinik, Heinrich Heine University, Düsseldorf, Germany. Frank.Schwarz@med.uni-dueseldorf.de
Sager
Martin
M
Ferrari
Daniel
D
Herten
Monika
M
Wieland
Marco
M
Becker
Jürgen
J
D000539:Alveolar Process / Q000033:anatomy & histology*; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D004285:Dogs; D011897:Random Allocation; D013499:Surface Properties; D013529:Surgical Wound Dehiscence / Q000628:therapy*; D013997:Time Factors; D014025:Titanium
D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D014025:Titanium