Aspirin-sensitive asthma: recent advances in management.
AbstractAspirin (ASA)-sensitive asthma is characterised by a typical sequence of symptoms, including intense eosinophilic inflammation of nasal and bronchial tissues. It is more commonly found in non-atopic, middle-aged female asthmatic patients with chronic rhino-sinusitis and/or nasal polyps. The lysine-aspirin bronchoprovocation test has become a widely used diagnostic test. When ASA-sensitive asthma is confirmed, complete avoidance of ASA/non-steroidal anti-inflammatory agents (NSAIDs) is crucial in preventing life-threatening adverse reactions. The basic principle of pharmacotherapy is step-wise treatment based upon anti-inflammatory therapy. Corticosteroids are the mainstay of therapy and anti-leukotriene agents may be indicated for treatment of the underlying disease.ASA desensitisation may reduce inflammatory mucosal disease symptoms,particularly in the nasal passage.
Department of Allergy and Clinical Immunology, Ajou University Schoolof Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
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