Evaluation of genetic markers linked to hemophilia A locus: an Indian experience.
Hemophilia A is an X-linked recessive bleeding disorder caused by defects in factor VIII gene (F8). Our study examines variations of single nucleotide polymorphism (SNP) in F8 in the Indian population and establishes the utility of a combination of SNP and microsatellite markers for the successful identification of carriers in the affected families.
Molecular & Human Genetics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata, 700 032, India.
Atreyee
A
Saha
Saibal
S
Mukherjee
Mahua
M
Maulik
Giriraj Ratan
GR
Chandak
Kunal
K
Ray
D005069:Evaluation Studies as Topic; D005260:Female; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006467:Hemophilia A / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics*
D005819:Genetic Markers