Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosis.
BACKGROUND
Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclear.


OBJECTIVE
To assess regional grey matter volume in the at-risk individuals who subsequently developed psychosis.


METHODS
Magnetic resonance imaging data from at-risk individuals who developed psychosis (n=12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25).


RESULTS
Compared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilaterally and smaller grey matter volume in the right lentiform nucleus.


CONCLUSIONS
Some of the structural brain abnormalities in individuals with an at-risk mental state may be related to an increased vulnerability to psychosis, while others are associated with the development of a psychotic illness.
Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Stefan J
SJ
Borgwardt
Philip K
PK
McGuire
Jacqueline
J
Aston
Gregor
G
Berger
Paola
P
Dazzan
Ute
U
Gschwandtner
Marlon
M
Pflüger
Marcus
M
D'Souza
Ernst-Wilhelm
EW
Radue
Anita
A
Riecher-Rössler
D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000473:pathology*; D012307:Risk Factors; D012559:Schizophrenia / Q000473:pathology; D012569:Schizotypal Personality Disorder / Q000473:pathology