The applicability of an amidated polysaccharide hydrogel as a cartilage substitute: structural and rheological characterization.
An amidic derivative of a carboxymethylcellulose-based hydrogel was obtained and characterized in terms of amidation degree. NMR studies and FT-IR imaging spectroscopy demonstrated that the reaction allowed a polymer to be obtained that was characterized by a regular distribution of amidic groups along the polysaccharide chains. Through this regularity, a homogenous three-dimensional scaffold was obtained, which maintained the thixotropic property of the linear polysaccharide.
CRISMA and Department of Chemical and Biosystem Science and Technologies, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Gemma
G
Leone
Maurizio
M
Delfini
Maria Enrica
ME
Di Cocco
Anna
A
Borioni
Rolando
R
Barbucci
D000577:Amides; D001672:Biocompatible Materials / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium; D002356:Cartilage; D020100:Hydrogels / Q000737:chemistry* / Q000627:therapeutic use; D011134:Polysaccharides / Q000737:chemistry* / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D014783:Viscosity
D000577:Amides; D001672:Biocompatible Materials; D020100:Hydrogels; D011134:Polysaccharides; D002266:Carboxymethylcellulose Sodium