Neurocognitive outcomes 3 years after coronary artery bypass graft surgery: a controlled study.
BACKGROUND
Cardiopulmonary bypass has been implicated in the late cognitive decline that has been reported after coronary artery bypass graft (CABG) surgery. Because most studies did not include a control group, a causal link of such decline with the use of cardiopulmonary bypass has not been established.


METHODS
We compared changes in cognitive performance from baseline to 3 years in patients undergoing on-pump CABG (n = 152) with those of three control groups: patients with off-pump surgery (n = 75); with diagnosed coronary artery disease but no surgery (n = 99); and without coronary artery disease risk factors (n = 69). Neuropsychological performance was assessed by standardized tests of attention, language, verbal and visual memory, visuospatial, executive function, and psychomotor and motor speed.


RESULTS
Relative to their baseline performance, no group had significantly lower performance at 36 months for any of the cognitive domains. From 12 to 36 months, there were no statistically significant differences in the degree of change between the on- and off-pump surgery groups. There was a trend toward mild decline in some cognitive domains, but overall differences among groups in degree of change over time were not statistically significant.


CONCLUSIONS
We found a mild but nonsignificant trend toward late postoperative cognitive decline for all study groups with coronary artery disease, but no significant differences in the degree of late postoperative cognitive decline after on-pump compared with off-pump surgery. These findings suggest that previously reported late decline after bypass surgery is not specific to use of cardiopulmonary bypass.
Selnes
Ola A
OA
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. oselnes@jhmi.edu
Grega
Maura A
MA
Bailey
Maryanne M
MM
Pham
Luu
L
Zeger
Scott
S
Baumgartner
William A
WA
McKhann
Guy M
GM
D000368:Aged; D000544:Alzheimer Disease / Q000209:etiology; D053327:Apolipoprotein E4 / Q000235:genetics; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002561:Cerebrovascular Disorders / Q000523:psychology; D003072:Cognition Disorders / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003327:Coronary Disease / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D016896:Treatment Outcome
D053327:Apolipoprotein E4