Genetics of migraine and pharmacogenomics: some considerations.
Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response.
Piane
Maria
M
Department of Diagnostic Sciences, Medical Genetics Section, 2nd School of Medicine, University of Rome La Sapienza, I-00185, Rome, Italy. maria.piane@uniroma1.it
Lulli
Patrizia
P
Farinelli
Ivano
I
Simeoni
Simona
S
De Filippis
Sergio
S
Patacchioli
Francesca Romana
FR
Martelletti
Paolo
P
D000700:Analgesics / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics
D000700:Analgesics