The versatility of Shigella effectors.
When Shigella infect the intestinal epithelium, they deliver several effectors through the type III secretion system (T3SS) into the surrounding space and directly into the host-cell cytoplasm, where they can mimic and usurp host cellular functions or subvert host-cell signalling pathways and the immune response. Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection.
Ogawa
Michinaga
M
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Handa
Yutaka
Y
Ashida
Hiroshi
H
Suzuki
Masato
M
Sasakawa
Chihiro
C
D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology; D004405:Dysentery, Bacillary / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000382:microbiology; D012760:Shigella / Q000472:pathogenicity / Q000502:physiology*
D001426:Bacterial Proteins