Osteonecrosis in children and adolescents with cancer.
Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non-Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children >/=10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight-bearing joints predominantly. It is commonly bilateral and multi-articular. Treatment options include both surgical and non-surgical interventions.
Barr
Ronald D
RD
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. rbarr@mcmaster.ca
Sala
Alessandra
A
D000293:Adolescent; D002648:Child; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D010020:Osteonecrosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics; D012307:Risk Factors; D012727:Sex Characteristics