Synthesis of new bisaryl cyclopentathiophene and thienocyclopentoxazolidine derivatives as potential cytotoxic agents.
The synthesis of new bisaryl thienocyclopentoxazolidine derivatives was achieved through a Suzuki cross-coupling procedure with the aim to enhance the previously reported cytotoxicity of the series. The biological activity, evaluated in the NCI's in vitro human disease-oriented tumor cell line screening panel, was however partially conserved by the pharmacomodulations.
Omran
Ziad
Z
Centre d'Etudes et de Recherche sur le Médicament de Normandie UFR des Sciences Pharmaceutiques Université de Caen Basse Normandie, 5 rue Vaubénard, 14032 Caen cedex France.
Dallemagne
Patrick
P
Rault
Sylvain
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001966:Bromine / Q000737:chemistry; D045744:Cell Line, Tumor; D003432:Cross-Linking Reagents / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D003517:Cyclopentanes; D006841:Hydrocarbons, Aromatic; D010080:Oxazoles; D013876:Thiophenes; C064210:oxazolidine; D001966:Bromine