Prednisone vs. placebo in withdrawal therapy following medication overuse headache.
This proof-of-concept study evaluated the efficacy of prednisone for the treatment of withdrawal symptoms in patients with medication overuse headache (MOH) in a randomized, placebo-controlled, double-blind design. Twenty patients were randomized and underwent in-patient withdrawal therapy. The total number of hours with severe or moderate headache within the first 72 and 120 h was significantly lower in the prednisone group. The results show that prednisone might be effective in the treatment of medication withdrawal headache.
Department of Neurology, Cologne City Hospitals, Cologne, Germany. pagelerl@kliniken-koeln.de
L
L
Pageler
Z
Z
Katsarava
H C
HC
Diener
V
V
Limmroth
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D051271:Headache Disorders, Secondary / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011241:Prednisone / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D011241:Prednisone