Transient increased extracellular release of H2O2 during establishment of UVB-induced premature senescence.
In this work, we found that extracellular release of H(2)O(2) is 1.5- to 6-fold higher in skin human diploid fibroblasts exposed to UVB in conditions inducing premature senescence when compared to control cells without exposure to UVB. The apparent decrease in H(2)O(2) production from 0 to 72 h after the last exposure to UVB was not due to increased enzymatic activity of catalase or glutathione peroxidase.
Research Unit on Cellular Biology, Department of Biology, Faculty of Sciences, University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium.
Celine
C
Borlon
Aline
A
Chretien
Florence
F
Debacq-Chainiaux
Olivier
O
Toussaint
D002374:Catalase / Q000378:metabolism; D002460:Cell Line; D004171:Diploidy; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D013997:Time Factors; D014466:Ultraviolet Rays
D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase