Role of the ubiquitin system and tumor viruses in AIDS-related cancer.
Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein-Barr virus and human papilloma virus, which are causally linked to Kaposi's sarcoma, certain B-cell lymphomas and cervical cancer, respectively. We discuss the molecular mechanisms by which these viruses subvert the ubiquitin system and potential viral targets for anti-cancer therapy from the perspective of this system. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Shackelford
Julia
J
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. shackelfordj@yahoo.com
Pagano
Joseph S
JS
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000201:enzymology* / Q000821:virology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000821:virology*; D009858:Oncogenic Viruses / Q000187:drug effects / Q000502:physiology*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000201:enzymology* / Q000821:virology*; D025801:Ubiquitin / Q000502:physiology*
D000970:Antineoplastic Agents; D025801:Ubiquitin