[Multiresistant tuberculosis in Brazil: history and control].
The article aimed at assessing multidrug-resistant tuberculosis control in Brazil, based on the experiences of reference institutions, and the most relevant studies carried out to determine local and national resistance rates. Control measures and the current situation of treatment and diagnoses after the implementation of the national guidelines, which were revised in 2004, are considered. The first national survey on resistance to anti-tuberculosis drugs was performed in the middle of last decade. From its outcomes, a regimen to treat all cases of multidrug-resistant tuberculosis was validated and adopted. Government measures enabled the implementation of a surveillance system, whose outcomes are also commented.
Dalcolmo
Margareth Pretti
MP
Centro de Referência Hélio Fraga, Ministério da Saúde, Rio de Janeiro, RJ, Brazil. margareth.dalcolmo@saude.gov.br
Andrade
Mônica Kramer de Noronha
MK
Picon
Pedro Dornelles
PD
D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D006306:Health Surveys; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D009154:Mutation / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics; D012293:Rifampin / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000266:history* / Q000517:prevention & control*
D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin