Application of modelling to determine the absence of foot-and-mouth disease in the face of a suspected incursion.
OBJECTIVE
To use disease modelling to inform a response team about the number of animals per herd/flock to be examined, and the start date and duration of clinical surveillance required to be confident that foot-and-mouth disease (FMD) was not present on an island in New Zealand with a population of approximately 1,600 cattle, 10,000 sheep and a small number of pigs, goats and alpacas.


METHODS
Because the probability of detecting clinical disease in (the) primary case(s) in larger herds and flocks was extremely low, deterministic and stochastic mathematical SLIR (susceptible, latent, infectious, recovered) models for the transmission of infection were constructed to estimate the date when clinical lesions in herds and flocks would be detected with 95% confidence. Surveillance targeted the first wave of infections following a suspect index case.


RESULTS
If 70 cattle in herds of about 400 cattle were examined it was estimated it would take approximately 13 (90% stochastic range 9-19) days from first exposure before it would be possible to achieve 95% confidence for detecting clinical signs for a low-virulence virus, and 9 (7-14) days for a high-virulence virus. The duration of sufficiently accurate clinical detection was 17 (15-19) days and 13 (12-14) days for low- and high-virulence viruses, respectively. A sample of 70 sheep from flocks of >1,000 would be required to achieve clinical detection at about the same time but with a shorter period of detection than for cattle. The duration of effective detection could be increased by examining a larger sample in most sheep flocks, however the small size of many cattle herds in the study population limited the confidence of detecting group-level disease in cattle, therefore necessitating repeated herd inspections. The model suggested that group-level detection was not feasible if it was based on elevated body temperature alone because of short durations of fever in infected animals.


CONCLUSIONS
Simulation modelling is a useful and powerful tool for informing ongoing surveillance activities in the face of an exotic disease incursion. Results of modelling suggested to start clinical inspection activities at 4 days and to continue regular inspection twice a week for about 35 days after the date of first exposure, to satisfy the required 95% confidence threshold of clinical detection of FMD in cattle herds and sheep flocks.
EpiCentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand. c.heuer@massey.ac.nz
C
C
Heuer
N P
NP
French
R
R
Jackson
G F
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Mackereth
D000818:Animals; D002161:Camelids, New World; D002417:Cattle; D003198:Computer Simulation; D016001:Confidence Intervals; D003937:Diagnosis, Differential; D005536:Foot-and-Mouth Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission*; D029544:Foot-and-Mouth Disease Virus / Q000472:pathogenicity; D006041:Goats; D006304:Health Status; D008403:Mass Screening / Q000379:methods / Q000592:standards / Q000662:veterinary*; D008954:Models, Biological; D009520:New Zealand; D011156:Population Density; D011159:Population Surveillance; D011237:Predictive Value of Tests; D015995:Prevalence; D011336:Probability; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018571:Sentinel Surveillance / Q000662:veterinary; D012756:Sheep; D013269:Stochastic Processes; D013552:Swine; D013997:Time Factors; D014774:Virulence