Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants.
This study evaluates the efficacy and tolerability of an investigational study cream composed of 3 ingredients (green and white teas, mangosteen, and pomegranate extract), Vitaphenol Skin Cream (La Jolla Spa MD, La Jolla CA), as compared to a placebo cream in rejuvenating facial skin. Twenty healthy females between the ages of 35 and 65 with demonstrable facial wrinkling, achieving a Rao-Goldman wrinkle scale score of 2 or above, applied either Vitaphenol Skin Cream or placebo cream to a randomized half of their face twice daily for 60 days and returned for follow-up after 2 weeks. Twice as many subjects indicated an enhancement of skin texture (eg, reduction in pore size, roughness, and touch) with the usage of Vitaphenol versus placebo. In all, 41% of the study subjects preferred the half of their face that had been receiving Vitaphenol, while only 0.06% of the subjects favored the placebo side. PRIMOS images from periorbital skin treated with Vitaphenol demonstrated an average improvement in skin smoothness of 1 mm3, whereas skin treated with placebo showed an average decrease in smoothness or an increase in skin roughness of 0.9 mm3. The addition of 3 antioxidants, green and white teas, mangosteen, and pomegranate, have an additive effect to enhance the improvement of age-related changes in the skin.
Hsu
Jessica
J
University of California, San Diego, USA.
Skover
Greg
G
Goldman
Mitchel P
MP
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D028241:Camellia sinensis; D004643:Emollients / Q000008:administration & dosage; D005145:Face / Q000473:pathology; D005260:Female; D029762:Garcinia mangostana; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D029561:Lythraceae; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects
D000975:Antioxidants; D004643:Emollients; D010936:Plant Extracts