Enantioselective intramolecular aldol reaction mediated by a combination of L-amino Acid and Brønsted Acid to construct a bicyclic enedione containing a 7-membered ring.
The enantioselectivity of the intramolecular asymmetric aldol reaction of 1,3-cycloheptanedione bearing a C-2 methyl substituent, mediated by a series of combinations of L-amino acid and Brønsted acid, was examined in detail.
Nagamine
Takashi
T
Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 81-8558, Japan.
Inomata
Kohei
K
Endo
Yasuyuki
Y
D000596:Amino Acids / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013696:Temperature
D000596:Amino Acids; D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D009281:Naphthalenes; D012997:Solvents