[Advances in the study of ginsenoside compound K].
Ginsenoside compound K is the main metabolite of protopanaxadiol type ginseng saponins in intestine after oral administration and also is the major form of protopanaxadiol saponins absorbed to the body. Recently, ginsenoside compound K has received increasing attention, because in vivo or in vitro various biological actions of anticancer, hepatoprotective and anti-inflammatory etc, have shown to be mediated by this metabolite. In this paper, the studies of preparation, bioactivities, absorption, distribution and pharmacokinetics of compound K were reviewed in detail.
Zhou
Wei
W
School of Pharmacy, Fudan University, Shanghai 200032, China.
Zhou
Pei
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D036145:Ginsenosides / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects; D005894:Panax / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology; D014018:Tissue Distribution
D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D020011:Protective Agents; C112772:ginsenoside compound K