Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder.
A deficit in cognitive flexibility is acknowledged as a cognitive trait for obsessive-compulsive disorder (OCD). However, no investigations to date have used a cognitive activation paradigm to specify the neural correlates of this deficit in OCD. The objective of this study was to clarify how abnormal brain activities relate to cognitive inflexibility in OCD, using a task-switching paradigm. A task-switching paradigm which has two kinds of task-set was applied to 21 patients with OCD and 21 healthy subjects of matching age, IQ and sex, during an event-related functional magnetic resonance imaging experiment. Compared with the healthy subjects, patients with OCD exhibited a significantly higher error rate in task-switch trials (P < 0.05). Healthy controls showed significant activation in various areas, including dorsal frontal-striatal regions, during task-switching, whereas patients with OCD showed no activation in these areas. Significant differences were also observed in the dorsal frontal-striatal regions and ventromedial prefrontal and right orbitofrontal cortexes between patients with OCD and healthy controls. Correlation analysis indicated that the activations of orbitofrontal cortex were related with the performance in both groups and also with the activation of anterior cingulate cortex in the OCD group. These findings replicate previous studies of cognitive inflexibility in OCD and provide neural correlates related to a task-switching deficit in OCD. The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits.
Gu
Bon-Mi
BM
Interdisciplinary Program in Brain Science, Seoul National University College of Medicine, Korea.
Park
Ji-Young
JY
Kang
Do-Hyung
DH
Lee
Seung Jae
SJ
Yoo
So Young
SY
Jo
Hang Joon
HJ
Choi
Chi-Hoon
CH
Lee
Jong-Min
JM
Kwon
Jun Soo
JS
D000328:Adult; D001288:Attention; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D003463:Cues; D004192:Discrimination, Psychological; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology*