Variability in cardiovascular control: the baroreflex reconsidered.
Although blood pressure control is often viewed as a paradigmatic example of a "homeostatic" biological control system, blood pressure levels can fluctuate considerably over shorter and longer time scales. In modern signal analysis, coherence between heart rate and blood pressure variability is used to estimate baroreflex gain. However, the shorter the measurement period, the more variability this gain factor reveals. We review evidence that this variability is not due to the technique used for the estimation, but may be an intrinsic property of the circulatory control mechanisms. The baroreflex is reviewed from its evolutionary origin, starting in fishes as a reflex mechanism to protect the gills from excessively high pressures by slowing the heart via the (parasympathetic) vagus nerve. Baroreflex inhibition of cardiovascular sympathetic nervous outflow is a later development; the maximally possible extent of sympathetic activity probably being set in the central nervous system by mechanisms other than blood pressure per se. In the sympathetic outflow tract not only baroreflex inhibition but also as yet unidentified, stochastic mechanisms decide to pass or not pass on the sympathetic activity to the periphery. In this short essay, the "noisiness" of the baroreflex as nervous control system is stressed. This property is observed in all elements of the reflex, even at the--supposedly--most basic relation between afferent receptor nerve input and efferent--vagus--nerve output signal.
Karemaker
John M
JM
Department of Physiology, Systems Physiology, Academic Medical Center, University of Amsterdam, Rm M01-216, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. j.m.karemaker@amc.uva.nl
Wesseling
Karel H
KH
D000818:Animals; D001158:Arteries / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D006321:Heart / Q000294:innervation* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D012680:Sensitivity and Specificity; D013564:Sympathetic Nervous System / Q000502:physiology*