Redoxcitrinin, a biogenetic precursor of citrinin from marine isolate of fungus Penicillium sp.
A chemical analysis of the fermentation of the marine-derived fungus Penicillium sp. led to the isolation of a biogenetic precursor of citrinin, redoxcitrinin (1), together with polyketide mycotoxins, phenol A (2), citrinin H2 (3), 4-hydroxymellein (4), citrinin (5), and phenol A acid (6). The structures of compounds 1-6 were determined on the basis of physicochemical data analyses. Among them, compounds 1-3 exhibited a potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values of 27.7, 23.4, and 27.2 microM, respectively.
Zhang
Dahai
D
College of Chemistry & Chemical Engineering, Ocean University of China, Qingdao 266003, PR China.
Li
Xianguo
X
Kang
Jung Sook
JS
Choi
Hong Dae
HD
Jung
Jee H
JH
Son
Byeng Wha
BW
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002953:Citrinin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C525788:4-hydroxymellein A; D000975:Antioxidants; D004952:Esters; D016166:Free Radical Scavengers; D049934:Isocoumarins; D010636:Phenols; D012118:Resorcinols; C465978:citrinin H2; C525787:redoxcitrinin; D002953:Citrinin