[The phenomenon of the single-strand DNA breaks level decrease in blood system cells in first generation chronically irradiated mice].
For the first time has been shown experimentally that chronic low dose-rate gamma-radiation (0.04 mGy/hr) exposure leads to decrease of the single-strand DNA breaks level in spleen cells in 2.3 times (p < 0.001) and blood leukocytes in 6.1 times (p < 0.01), a decrease of the apoptotic cells frequency in 1.3 times (p < 0.05) and an increase in the spleen relative mass ratio B 1.2 times (p < 0.001) in CBA mice offspings (F1) from the chronically irradiated parents and exposed to chronic irradiation during the embryonic and postembryonic periods. A hypothesis about the more compact chromatin structure of blood system cells in the individuals of the first generation from chronically irradiated mice is proposed.
Velegzhaninov
I O
IO
Moskalev
A A
AA
Osipov
A N
AN
D000818:Animals; D017209:Apoptosis; D004247:DNA / Q000032:analysis / Q000528:radiation effects*; D053904:DNA Breaks, Single-Stranded; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000528:radiation effects; D005720:Gamma Rays; D007962:Leukocytes / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology / Q000528:radiation effects
D004247:DNA