Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia.
The patient was a 50-year-old male in 2002, who was first suspected of having a Brugada-type electrocardiogram (ECG). A drug challenge test using pilsicainide was performed and unmasked a typical coved type ST elevation followed by ventricular arrhythmias (VAs) manifesting a QRS pattern with a right bundle branch block and left axis deviation. Three years later, he was transferred to the emergency room due to a wide QRS tachycardia with the same QRS morphology as the VA that previously occurred in the drug challenge test. An ECG just after the recorded termination of the tachycardia exhibited a typical Brugada-type ECG. In an electrophysiological study, ventricular fibrillation could be easily induced with reproducibility. Since the clinical tachycardia could not be sustained by an isoproterenol infusion, mapping and catheter ablation targeting the pilsicainide-induced VAs was performed. The successful ablation site was the left mid-lower septal wall where a Purkinje potential was recorded and a false tendon was attached just to it.
Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan. ueyama23@yahoo.co.jp
Takeshi
T
Ueyama
Akihiko
A
Shimizu
Masahiro
M
Esato
Yasuhiro
Y
Yoshiga
Akira
A
Sawa
Shinsuke
S
Suzuki
Naoki
N
Sugi
Masunori
M
Matsuzaki
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D053840:Brugada Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D017115:Catheter Ablation; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D054088:Ventricular Septum / Q000601:surgery
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; C042288:pilsicainide