Nitazoxanide: clinical studies of a broad-spectrum anti-infective agent.
Nitazoxanide is a new compound with broad-spectrum activity against numerous intestinal protozoa, helminths and anaerobic bacteria. It is approved for the treatment of diseases caused by Giardia intestinalis and Cryptosporidium species. The drug is well tolerated, with few side effects and requires a short course of treatment. Further investigations regarding its use in patients with AIDS is needed. Nitazoxanide represents a significant advance in the treatment of intestinal parasitic infections worldwide.
Aslam
Saima
S
Michael E DeBakey VA Medical Center, Section of Infectious Diseases, Room 4B-370, 2002 Holcombe Blvd, Houston, TX 77030, USA. saslam@bcm.tmc.edu
Musher
Daniel M
DM
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000163:Acquired Immunodeficiency Syndrome; D000977:Antiparasitic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009574:Nitro Compounds; D010272:Parasitic Diseases / Q000188:drug therapy; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*
D000977:Antiparasitic Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide