[Genetic polymorphism of COMT in mental disorders].
Many neurobiochemical studies show abnormalities within dopaminergic neuropathways, particularly altered dopamine transmission in etiopathogenesis of mental disorders. Evaluation of genes associated with the dopaminergic system include five well known subtypes of dopaminergic receptors, dopamine transporter and enzymes associated with the synthesis and degradation of dopamine, such as tyrosine hydroxylase, dopa decarboxylase, monoamine oxidase (MAO) and catechol O-methyltransferase (COMT). None of these genes is 'a' pathognomonic factor of schizophrenia onset. In each sequence of the following genes 'a' functional polymorphism can occur. The polymorphisms of genes MAO-A and COMT have been described in relation to various expression or altered activity of these enzymes, their influence on cognitive functions, affective and anxiety disorders, learning disabilities, aggressive behaviour, eating disorders or gender differences.
Katedra i Klinika Psychiatrii AM w Lublinie.
Aneta
A
Tylec
Marta
M
Stryjecka-Zimmer
Katarzyna
K
Kucharska-Pietura
D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004296:Dopa Decarboxylase / Q000235:genetics; D004298:Dopamine / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D004296:Dopa Decarboxylase; D004298:Dopamine