Protein trafficking to apical organelles of malaria parasites - building an invasion machine.
Malaria is caused by four species of apicomplexan protozoa belonging to the genus Plasmodium. These parasites possess a specialized collection of secretory organelles called rhoptries, micronemes and dense granules (DGs) that in part facilitate invasion of host cells. The mechanism by which the parasite traffics proteins to these organelles as well as regulates their secretion has important implications for understanding the invasion process and may lead to development of novel intervention strategies. In this review, we focus on emerging data about trafficking signals, mechanisms of biogenesis and secretion. At least some of these are conserved in higher eukaryotes, suggesting that rhoptries, micronemes and DGs are related to organelles such as secretory lysosomes that are well known to mainstream cell biologists.
NHMRC Program in Malaria, Department of Microbiology, Monash University, Victoria 3800, Australia.
Lev M
LM
Kats
Brian M
BM
Cooke
Ross L
RL
Coppel
Casilda G
CG
Black
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D052940:Merozoites / Q000502:physiology; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D010961:Plasmodium / Q000502:physiology*; D021382:Protein Sorting Signals / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D022142:Secretory Vesicles / Q000378:metabolism / Q000469:parasitology
D021382:Protein Sorting Signals