14-3-3 cruciform-binding proteins as regulators of eukaryotic DNA replication.
Cruciforms are secondary DNA structures, serving as recognition signals at or near eukaryotic (yeast and mammalian) origins of DNA replication. The cruciform-binding protein is a member of the 14-3-3 protein family and binds to origins of DNA replication in a cell cycle-dependent manner. Five 14-3-3 protein isoforms (beta, gamma, epsilon, zeta and sigma) have been identified as having cruciform binding activity.
McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. maria.zannis@mcgill.ca
Maria
M
Zannis-Hadjopoulos
Wafaa
W
Yahyaoui
Mario
M
Callejo
D048948:14-3-3 Proteins / Q000502:physiology*; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone; D004261:DNA Replication / Q000502:physiology*; D045566:DNA, Cruciform / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D064126:Minichromosome Maintenance Complex Component 3; D064110:Minichromosome Maintenance Proteins; D009687:Nuclear Proteins / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
D048948:14-3-3 Proteins; C075852:BMH1 protein, S cerevisiae; C097164:BMH2 protein, S cerevisiae; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D045566:DNA, Cruciform; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C076365:MCM10 protein, S cerevisiae; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C115090:cruciform-specific DNA-binding protein, human; C069199:MCM2 protein, S cerevisiae; C507761:MCM3 protein, S cerevisiae; D064126:Minichromosome Maintenance Complex Component 3; D064110:Minichromosome Maintenance Proteins