The inhibitory collagen receptor LAIR-1 (CD305).
The immune system protects the body from invaders such as viruses and bacteria. Immune cells must be activated in the correct context to function properly. It is critical that the receptors, costimulatory molecules, and cytokines that orchestrate this activation are carefully regulated to prevent uncontrolled inflammation and autoimmunity. Inhibitory receptors play an important role in regulation of immune cell function, usually upon interaction with ligands present on other cells. In contrast, the function of the inhibitory leukocyte-associated Ig-like receptor (LAIR)-1 can be regulated by extracellular matrix collagens. LAIR-1 is expressed on most cells of the immune system, and its function has been studied on multiple cell types. This review summarizes current literature about LAIR-1, a receptor that potentially is able to regulate multiple steps of an immune response.
Department of Immunology, University Medical Center, Utrecht 3584 EA, The Netherlands. l.meyaard@umcutrecht.nl
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Meyaard
D000081247:CSK Tyrosine-Protein Kinase; D003001:Cloning, Molecular; D006706:Homeostasis; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D038981:Receptors, Collagen / Q000502:physiology; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D018909:src Homology Domains; D019061:src-Family Kinases
D011518:Proto-Oncogene Proteins; D038981:Receptors, Collagen; D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases; C000631346:CSK protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6