CD1 antigen presentation: how it works.
The classic concept of self-non-self discrimination by the immune system focused on the recognition of fragments from proteins presented by classical MHC molecules. However, the discovery of MHC-class-I-like CD1 antigen-presentation molecules now explains how the immune system also recognizes the abundant and diverse universe of lipid-containing antigens. The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in our understanding of how the processes of CD1 assembly, trafficking, lipid-antigen binding and T-cell activation are achieved and the new insights into how lipid antigens differentially elicit CD1-restricted innate and adaptive T-cell responses.
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA.
Duarte C
DC
Barral
Michael B
MB
Brenner
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000737:chemistry / Q000276:immunology*; D002352:Carrier Proteins / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D003460:Crystallization; D003713:Dendritic Cells / Q000378:metabolism; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D050356:Lipid Metabolism; D008055:Lipids / Q000276:immunology; D008213:Lymphocyte Activation; D021381:Protein Transport; D012503:Saponins / Q000494:pharmacology
D018949:Antigens, CD1; D002352:Carrier Proteins; D008055:Lipids; D012503:Saponins; C106092:microsomal triglyceride transfer protein