World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group.
Following from the publication of the International Retinoblastoma Staging System, an open internet discussion group was created at the www.cure4kids.org resource. The results of a survey distributed among participants are discussed. Although most patients with retinoblastoma were treated under prospective protocols, there was a wide variation in the definition of risk criteria and in the criteria for giving adjuvant chemotherapy following enucleation. Definition of high-risk histological features and the criteria for use of adjuvant therapy will be standardized in future studies. Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies.
Hospital JP Garrahan, Buenos Aires, Argentina and International Outreach Program, St Jude Children's Research Hospital, Memphis, Tennessee, USA. guillermo.chantada@stjude.org
Guillermo L
GL
Chantada
François
F
Doz
Manuela
M
Orjuela
Ibrahim
I
Qaddoumi
Rita S
RS
Sitorus
Tomas
T
Kepak
Anna
A
Furmanchuk
Mauricio
M
Castellanos
Tarun
T
Sharma
Patricia
P
Chevez-Barrios
Carlos
C
Rodriguez-Galindo
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000592:standards* / Q000706:statistics & numerical data; D002675:Child, Preschool; D002829:Choroid / Q000473:pathology; D003131:Combined Modality Therapy / Q000592:standards / Q000706:statistics & numerical data; D003226:Congresses as Topic / Q000458:organization & administration* / Q000706:statistics & numerical data; D003625:Data Collection; D003906:Developing Countries; D019468:Disease Management; D015353:Eye Enucleation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D038622:Internationality; D020407:Internet; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging / Q000379:methods / Q000592:standards*; D017410:Practice Guidelines as Topic; D018714:Radiotherapy, Adjuvant / Q000592:standards / Q000706:statistics & numerical data; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018570:Risk Assessment