Tacrolimus-related polyneuropathy: case report and review of the literature.
Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all 11 reported FK506-associated polyneuropathies is given.
Department of Critical Care Medicine, University Hospital of Antwerp, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium.
Annick
A
De Weerdt
Kristl G
KG
Claeys
Peter
P
De Jonghe
Dirk
D
Ysebaert
Thiery
T
Chapelle
Geert
G
Roeyen
Philippe G
PG
Jorens
D000328:Adult; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation / Q000276:immunology; D008279:Magnetic Resonance Imaging; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications / Q000601:surgery; D016035:Pancreas Transplantation / Q000276:immunology; D010180:Pancreatectomy; D011115:Polyneuropathies / Q000139:chemically induced* / Q000188:drug therapy; D016559:Tacrolimus / Q000009:adverse effects*
D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016559:Tacrolimus