[Autopsy case of aspirin intoxication: distribution of salicylic acid and salicyluric acid in body fluid and organs].
A 52 year-old woman ingested approximately 300 tablets (325 mg) of aspirin in a suicide attempt. We analyzed the concentrations of salicylic acid (SA) and salicyluric acid (SUA) in body fluids and organs using a modified previous high-performance liquid chromatographic method. The concentrations of SA in heart and femoral blood were 1.1 mg/mL and 1.3 mg/mL, respectively; the results were far higher than the lethal level. The concentration of SA was 0.3-0.4 mg/g in brain, 0.9-1.4 mg/g in lung, 0.6-0.8 mg/g in liver and 0.9 mg/mL in kidney.
Department of Legal Medicine, School of Medicine, University of the Ryukyus, Okinawa.
Yoko
Y
Ihama
Saori
S
Ageda
Chiaki
C
Fuke
Tetsuji
T
Miyazaki
D001241:Aspirin / Q000378:metabolism* / Q000506:poisoning*; D001344:Autopsy; D001826:Body Fluids / Q000737:chemistry*; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006626:Hippurates / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry*; D020156:Salicylic Acid / Q000032:analysis*; D014018:Tissue Distribution
D006626:Hippurates; C000693:salicylurate; D020156:Salicylic Acid; D001241:Aspirin