Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.
Ohioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B). Kinetic analysis of PTP1B inhibition by ohioensin F (1) suggested that benzonaphthoxanthenones inhibited PTP1B activity in a non-competitive manner.
College of Medical and Life Sciences, Silla University, San 1-1 Gwaebeop-dong, Sasang-gu, Busan 617-736, Republic of Korea.
Changon
C
Seo
Yun-Hyeok
YH
Choi
Jae Hak
JH
Sohn
Jong Seog
JS
Ahn
Joung Han
JH
Yim
Hong Kum
HK
Lee
Hyuncheol
H
Oh
D000864:Antarctic Regions; D044002:Bryophyta / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D014966:Xanthenes; C528982:ohioensin F; C528981:ohioensin G; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1