Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers.
Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully used for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles). Here, we will consider the main results in this area, with a special emphasis on TATp-mediated delivery of liposomes and DNA. We will also address the development of "smart" stimuli-sensitive nanocarriers, where cell-penetrating function can be activated by the decreased pH only inside the biological target minimizing thus the interaction of drug-loaded nanocarriers with non-target cells.
Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA. v.torchilin@neu.edu
Vladimir P
VP
Torchilin
D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D015696:Gene Products, tat / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*
D004337:Drug Carriers; D015696:Gene Products, tat