Insulin-like growth factor I concentration in dogs with inflammatory and neoplastic liver diseases.
Liver diseases are known to influence the serum concentration of insulin-like growth factor I (IGF-I) in humans, but such an effect has rarely been investigated in dogs. The aim of this study was to investigate serum IGF-I concentrations in dogs with primary liver diseases, in comparison with levels in healthy dogs and dogs with non-hepatic diseases. For this purpose, IGF-I serum concentrations were measured (DSL-5600 kit) in 36 dogs with various liver diseases and compared with 22 healthy controls and 20 dogs with non-hepatic diseases. The results showed that dogs with liver diseases had significantly lower IGF-I serum concentrations (P < 0.001) than clinical healthy dogs or dogs with non-hepatic diseases. But the results also indicate that the aetiology of liver disease has no influence on IGF-I serum concentration.
Institute of Veterinary Medicine, University of Goettingen, Burckhardtweg 2, D-37077 Goettingen, Germany. sneuman@gwdg.de
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Neumann
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Welling
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Thuere
D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary*; D008113:Liver Neoplasms / Q000097:blood / Q000662:veterinary*; D008297:Male
D007334:Insulin-Like Growth Factor I