Influence of race and sex on lipoprotein-associated phospholipase A2 levels: observations from the Dallas Heart Study.
OBJECTIVE
Most lipoprotein-associated phospholipase A2 (Lp-PLA2) studies included mainly white men. We sought to determine whether Lp-PLA2 levels differ according to race and sex.


METHODS
Lp-PLA2 mass and activity were measured in 3332 subjects age 30-65 participating in the Dallas Heart Study, a multiethnic, population-based, probability sample. Lp-PLA2 levels were compared between different race and sex groups.


RESULTS
Mean age was 45+/-9 years and 44% were men; 30% were white, 17% hispanic, and 53% black. Mean Lp-PLA2 activity and mass were 146+/-40 nmol/min/mL and 191+/-60 ng/mL, respectively. Lp-PLA2 activity was lower in women compared with men (134+/-35 vs. 161+/-40, p=0.001) and was lowest in black (136+/-38), intermediate in hispanic (151+/-36), and highest in white subjects (161+/-39) (trend p=0.0001). In multivariable linear regression models, after adjusting for age, body mass index (BMI), smoking, total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglycerides and high sensitivity C-reactive protein (hsCRP), Lp-PLA2 activity was 19 nmol/min/mL higher in men vs. women (p<0.001); compared with black subjects, adjusted Lp-PLA2 activity was 11 and 20 nmol/min/mL higher in white and hispanic subjects, respectively (both p<0.001). Similar race and sex differences were observed for Lp-PLA2 mass.


CONCLUSIONS
Race and sex independently influence Lp-PLA2 activity and mass. Thresholds to define Lp-PLA2 elevation may need to be sex and race specific.
Brilakis
Emmanouil S
ES
The Donald W. Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center in Dallas, TX, United States. emmanouil.brilakis@utsouthwestern.edu
Khera
Amit
A
McGuire
Darren K
DK
See
Raphael
R
Banerjee
Subhash
S
Murphy
Sabina A
SA
de Lemos
James A
JA
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000368:Aged; D044383:Black People / Q000706:statistics & numerical data; D008078:Cholesterol, LDL / Q000378:metabolism; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000208:ethnology* / Q000378:metabolism*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D044469:Racial Groups / Q000706:statistics & numerical data*; D012307:Risk Factors; D017678:Sex Distribution; D013781:Texas / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American
D008078:Cholesterol, LDL; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase