Simulated neonatal exposure to DEHP and MEHP from PVC enteral nutrition products.
The leaching of di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) from medical products made of polyvinyl-chloride (PVC) to enteral nutrition (EN) for neonatal patients was determined in a simulated study. The study simulated a typical case of EN administration to a neonatal patient (body weight, 3 kg) in a neonatal care unit (temperature, 25 degrees C); the medical products used were an irrigator and catheter containing DEHP (9.1-31.8%, w/w) as a plasticizer. The worst-case daily exposures of the neonatal patient to DEHP and MEHP by the administration of EN were estimated to be 148 and 3.72 microg/(kg day), respectively, as assessed from the levels of these compounds leaching from the medical products to the EN. The use of DEHP-free medical products reduced the exposure of DEHP and MEHP to the minimum levels contained in the EN at preparation. A transition to DEHP-free medical products for neonatal patients would be effective in reducing the exposure of neonatal patients to DEHP via EN administration.
Takatori
Satoshi
S
Division of Food Chemistry, Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. sts-tkt@iph.pref.osaka.jp
Okamoto
You
Y
Kitagawa
Yoko
Y
Hori
Shinjiro
S
Izumi
Shun-Ichiro
S
Makino
Tsunehisa
T
Nakazawa
Hiroyuki
H
D002851:Chromatography, High Pressure Liquid; D004051:Diethylhexyl Phthalate / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D004750:Enteral Nutrition / Q000009:adverse effects* / Q000295:instrumentation; D004867:Equipment Design; D005506:Food Contamination / Q000517:prevention & control*; D006801:Humans; D041943:Infant Formula / Q000737:chemistry*; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D010968:Plasticizers / Q000009:adverse effects / Q000032:analysis*; D011143:Polyvinyl Chloride / Q000009:adverse effects / Q000737:chemistry*; D018570:Risk Assessment; D021241:Spectrometry, Mass, Electrospray Ionization; D013059:Spectrum Analysis, Raman; D053719:Tandem Mass Spectrometry
D010968:Plasticizers; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate