Hemodynamic variation following induction and tracheal intubation--thiopental vs propofol.
OBJECTIVE
Hemodynamic variations are inevitable during induction of anesthetic drugs. The present study, investigates the hemodynamic variations of two different drugs used for induction; Thiopental vs. Propofol.


METHODS
In a prospective randomized double-blind study, from June 2003 to November 2004, 120 (ASA I and II) patients scheduled for elective surgery, were randomly divided into two equal groups. Patients were premedicated with midazolam (0.05 mg/kg) and fentanyl (1 microg/kg). Anesthesia was induced with either thiopental 5 mg/kg (group T) or propofol 2 mg/kg (group P). Neuromuscular blockade was achieved with atracurium (0.5 mg/kg) and anesthesia was maintained with halothane 1%, nitrous oxide (67%) in O2. Hemodynamic variable (systolic and diastolic blood pressure, mean arterial pressure and heart rate) were measured non-invasively in three periods: before drug administration, immediately after injection, prior to intubation, and finally immediately after intubation.


RESULTS
the incidence of hemodynamic changes in systolic, diastolic, mean arterial blood pressures and heart rate were significantly higher in group T compared to group P.


CONCLUSIONS
We conclude that Propofol causes less hemodynamic changes compared to Thiopental. Therefore, we recommend Propofol especially when dealing with hemodynamically compromised patients.
Safaee
Mohammad-Hadi
MH
Department of Anesthesiology, Motahari Hospital, Jahrom University of Medical Sciences, Jahrom, Iran. safaee@jums.ac.ir
Sepidkar
Abdolali
A
Eftekharian
Hamid Reza
HR
D000328:Adult; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007431:Intraoperative Complications; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies; D013874:Thiopental / Q000009:adverse effects*
D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol