Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice.
Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD.
Department of Experimental Medicine, II University of Naples, Italy.
L A
LA
Ruocco
D
D
Viggiano
M
M
Pignatelli
T
T
Iannaccone
M G
MG
Rimoli
D
D
Melisi
A
A
Curcio
S
S
De Lucia
E
E
Carboni
U A
UA
Gironi Carnevale
P
P
de Caprariis
A G
AG
Sadile
D000704:Analysis of Variance; D000818:Animals; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000008:administration & dosage / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D005260:Female; D005690:Galactose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology*; D013045:Species Specificity; D018709:Statistics, Nonparametric
D004337:Drug Carriers; D004298:Dopamine; D005690:Galactose