Breaking the cycle of translation.
In a recent issue of Molecular Cell, Trobro and Aqvist (2007) reported mechanistic insight into release factor-induced peptide hydrolysis. Now, in this issue, the Green research group establishes unexpected complexity in decoding translation stop codons (Youngman et al., 2007).
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. jason.rife@vcu.edu
Jason P
JP
Rife
Gloria M
GM
Culver
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018388:Codon, Terminator / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D010303:Paromomycin / Q000494:pharmacology; D010454:Peptide Termination Factors / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000187:drug effects
D000900:Anti-Bacterial Agents; D018388:Codon, Terminator; D010454:Peptide Termination Factors; D010455:Peptides; D012346:RNA, Transfer, Amino Acyl; D010303:Paromomycin