Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.
A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
Sauvage
Magdalena M
MM
Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
Fortin
Norbert J
NJ
Owens
Cullen B
CB
Yonelinas
Andrew P
AP
Eichenbaum
Howard
H
D000818:Animals; D001522:Behavior, Animal; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology; D003216:Conditioning, Operant; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009812:Odorants; D009833:Olfactory Pathways / Q000503:physiopathology; D012372:ROC Curve; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000502:physiology*