[Parathyroid and bone. The mechanism of anabolic function of parathyroid hormone on bone].
Parathyroid hormone (PTH) has been applied to postmenopausal women and several studies revealed that intermittent PTH treatment significantly increases lumbar bone mineral density and reduces fracture risk. However, the mechanism of PTH anabolic function on bone is not fully understood yet. PTH receptors (PPR) are expressed in osteoblasts and PPR stimulates multiple intracellular signal pathways, including those mediated by cAMP-PKA signaling pathway and PLC-PKC signaling pathway. Several studies demonstrate that the PKA signaling through G-proteins in osteoblasts play important roles in regulating gene expression and osteogenesis by PTH.
University of Tokyo, Division of Tissue Engineering.
Naoshi
N
Ogata
Hiroshi
H
Kawaguchi
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects; D053244:Osteoprotegerin; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology*; D053245:RANK Ligand; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013268:Stimulation, Chemical
D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D044168:Receptor, Parathyroid Hormone, Type 1; D017868:Cyclic AMP-Dependent Protein Kinases; D019204:GTP-Binding Proteins