Leuprolide acetate and central retinal vein occlusion.
A 63-year-old man suffered a central retinal vein occlusion 2 months after he began taking leuprolide acetate for prostate cancer. Despite control for possible systemic hypertension (126/90 mm Hg) and mild hypercholesterolemia (total cholesterol level =246 mg/dL [range: 16 to 200 mg/dL], high-density lipoprotein level =67 mg/dL [range: 40 to 59 mg/dL], and low-density lipoprotein level =144 mg/dL [range: 0 to 130 mg/dL]), progression of the venous occlusive disease occurred. Leuprolide acetate, which is associated with thromboembolic events and diffuse intravascular coagulation, may be implicated in central retinal vein occlusion.
Department of Ophthalmology, University of South Carolina, 4 Medical Park, Suite 300, Columbia, SC 29203, USA. tfederici@gmail.com
Thomas J
TJ
Federici
D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D005451:Fluorescein Angiography; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide