[Digestive polyposis. Retrospective study of 20 cases].
BACKGROUND
Three main polyposis syndromes are transmitted as an autosomal dominant disorder: familial adenomatous polyposis (FAP), juvenile polyposis syndrome (JPS) and Peutz-Jeghers syndrome.


OBJECTIVE
Evaluate this management of digestive polyposis.


METHODS
Our study included 20 patients which were collected in th departements of pathology surgery and garstroenterology of MT Maarmouri's Hospital, Nabeul city.


RESULTS
We reported 15 cases of adenomatous polyposis with 2 family groups. We identified a family group of JPS with 3 members and 2 cases of Peutz-Jeghers syndrome. We found 11 cases of colonic adenocarcinoma out of the 15 patients affected by adenomatous polyposes. FAP is a generalized disorder involving the entire colorectum segment with numerous extra-colonic manifestations. The risk to develop colonic cancer is 100%. JPS is characterised by the development of numerous gastrointestinal juvenile polyps and occurs usually before 20 years old, the progression to cancer is rarely observed.


CONCLUSIONS
Peutz-Jeghers syndrome consists in hamartomatous polyps associated to a characteristic mucosal pigmentation. The patients are usually young adults and have an increased incidence of cancer in extradigestive sites.
Service d'Anatomie et de Cytologie Pathologiques, Hôpital MT Maamouri de Nabeul, route de Mrezka, Nabeul, Tunisie.
Samia
S
Chatti-Dey
Leila
L
Bacha
Essia
E
Saiji
Yossra
Y
Zidi
Ehsen
E
Ben Brahim
Mourad
M
Ben Othman
Mohamed Heykel
MH
Ezzine
Hassen
H
Touinsi
Taieb
T
Zouaoui
Sadok
S
Sassi
Msaddek
M
Azzouz
D000230:Adenocarcinoma / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D044483:Intestinal Polyposis / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies