Generation, basic chemistry, and detection of N-nitrosotryptophan derivatives.
N-Terminal blocked tryptophan derivatives like melatonin or tryptophan residues in peptides are easily nitrosated at the nitrogen atom of the indole ring to give the corresponding N-nitrosotryptophan derivatives. This article provides a comprehensive view of the synthesis, chemical properties, and detection methods of this class of N-nitroso compounds of potential importance in biological systems.
Institut für Physiologische Chemie, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. michael.kirsch@uni-duisburg-essen.de
Michael
M
Kirsch
Hans-Gert
HG
Korth
D019793:Fluorescein; D009682:Magnetic Resonance Spectroscopy; D009590:Nitrogen Radioisotopes; D009603:Nitroso Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D014364:Tryptophan / Q000737:chemistry*
D009590:Nitrogen Radioisotopes; D009603:Nitroso Compounds; D014364:Tryptophan; D019793:Fluorescein