Scleritis and peripheral ulcerative keratitis.
Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and require early diagnosis and treatment. Nearly two thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy and one fourth need a glucocorticoid-sparing agent as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. A detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are important in the exclusion of underlying disorders and extraocular involvement.
Galor
Anat
A
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, 550 North Broadway, Suite 700, Baltimore, MD 21205, USA.
Thorne
Jennifer E
JE
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000453:epidemiology; D015897:Comorbidity; D003320:Corneal Ulcer / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015423:Scleritis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids