Alternative and improved syntheses of highly potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA.
Improved syntheses of potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA were accomplished from cheap stating material, D-ribose. New synthetic methods were found to be superior to old methods from the viewpoint of use of cheap starting material, number of steps, and overall yields.
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Xiyan
X
Hou
Hyuk Woo
HW
Lee
Dilip K
DK
Tosh
Long Xuan
LX
Zhao
Lak Shin
LS
Jeong
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D058909:Adenosine A3 Receptor Agonists; D015394:Molecular Structure; D012266:Ribose / Q000737:chemistry*; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
C510478:2-chloro-N(6)-(3-iodobenzyl)-5'-N-methylcarbamoyl-4'-thioadenosine; D058909:Adenosine A3 Receptor Agonists; D013872:Thionucleosides; C504222:thio-Cl-IB-MECA; D012266:Ribose; D000241:Adenosine