Aspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver.
Intraperitoneal injections of lysine acetylsalicylate (L-ASA, aspirin) in a dose of 10 mg during 5 consecutive days to BALB/c and B10.PL mice increased the concentration of endogenous hydrogen sulfide in their livers. The rise of hydrogen sulfur levels was shown also in brains of BALB/c females and B10.PL males, however in BALB/c male brains there is no statistically significant difference. The mechanism of aspirin action on H2S concentration is discussed.
Srebro
Zbigniew
Z
Zakład Biologii Rozwoju Człowieka, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Somogyi
Eugeniusz
E
Wiliński
Bogdan
B
Góralska
Marta
M
Wiliński
Jerzy
J
Sura
Piotr
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism*; D012737:Sex Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009569:Nitric Oxide; D012436:S-Adenosylmethionine; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate; D006862:Hydrogen Sulfide