The JNK pathway and neuronal migration.
The c-Jun N-terminal kinases (JNKs) are important regulators of a variety of physiological and pathological processes both in the central and in the peripheral nervous systems. JNKs are considered as crucial mediators of neuronal cell death in response to stress and injury. However, recent studies have provided substantial evidence that the JNK pathway plays an important role in neuronal migration. Here, we will give a brief introduction of the JNK signaling pathway and put more emphasis on its role in neuronal migration.
Sun
Yiming
Y
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Yang
Tao
T
Xu
Zhiheng
Z
D000818:Animals; D002465:Cell Movement; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D015398:Signal Transduction
D048031:JNK Mitogen-Activated Protein Kinases