Aldehydic oligonucleotide: a key intermediate for the preparation of oligonucleotide conjugates through oxime bond formation.
Oligonucleotides functionalized with an aldehyde group are the key intermediates used for the preparation of peptide-oligonucleotide conjugates through the formation of an oxime linkage. Herein, we describe a brief overview of various synthetic protocols developed in our laboratory for the preparation of aldehyde containing oligonucleotides and their subsequent conjugation with peptides.
Spinelli
N
N
Département de Chimie Moléculaire-UMR CNRS 5250, ICMG FR2607, Université Joseph Fourier, Grenoble, Cedex 9, France.
Singh
Y
Y
Defrancq
E
E
Dumy
P
P
D000447:Aldehydes / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
D000447:Aldehydes; D009838:Oligodeoxyribonucleotides; D010091:Oximes; D020135:Peptide Nucleic Acids; D010455:Peptides