Discontinued drugs in 2006: anti-infectives.
Of the drugs dropped from development in 2006, 11 were being developed for infectious diseases. Of these, nine were for viral diseases, including four against HIV, two against hepatitis C virus and one each against respiratory syncytial virus, severe acute respiratory syndrome (coronavirus) and a variety of viruses. The nine antiviral agents comprised six synthetic small-molecule compounds, one peptide, one monoclonal antibody and a vaccine. The remaining two agents were a vaccine for Pseudomonas aeruginosa infection, and lipid-based agent for septic shock. Each of these drugs is briefly reviewed and reasons for failure are discussed.
Ryder
Neil S
NS
Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., 500 Technology Square, Cambridge, MA 02139, USA. neil.ryder@novartis.com
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000097:blood / Q000188:drug therapy; D006801:Humans; D013678:Technology, Pharmaceutical / Q000639:trends*
D000890:Anti-Infective Agents