Modulation of horizontally acquired genes by the Hha-YdgT proteins in Salmonella enterica serovar Typhimurium.
We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.
Departament de Microbiologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain.
Aitziber
A
Vivero
Rosa C
RC
Baños
Javier F
JF
Mariscotti
Juan Carlos
JC
Oliveros
Francisco
F
García-del Portillo
Antonio
A
Juárez
Cristina
C
Madrid
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D022761:Gene Transfer, Horizontal; D051379:Mice; D008807:Mice, Inbred BALB C; D020543:Proteome; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D014158:Transcription, Genetic; D014774:Virulence
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria; D020543:Proteome