Inhibition and brain work.
The major part of the brain's energy budget ( approximately 60%-80%) is devoted to its communication activities. While inhibition is critical to brain function, relatively little attention has been paid to its metabolic costs. Understanding how inhibitory interneurons contribute to brain energy consumption (brain work) is not only of interest in understanding a fundamental aspect of brain function but also in understanding functional brain imaging techniques which rely on measurements related to blood flow and metabolism. Herein we examine issues relevant to an assessment of the work performed by inhibitory interneurons in the service of brain function.
Buzsáki
György
G
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA. buzsaki@axon.rutgers.edu
Kaila
Kai
K
Raichle
Marcus
M
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D007473:Ion Channels; D005680:gamma-Aminobutyric Acid; D010100:Oxygen