Chronic bullous disease of childhood in a patient with acute lymphoblastic leukemia: possible induction by a drug.
Linear IgA disease is characterized by the presence of linear IgA deposits in the basement membrane zone of the skin, and circulating basement membrane zone antibodies are detected in 80% of cases. The disease occurs in both adults and children, and is designated adult linear IgA disease in the former and chronic bullous disease of childhood (CBDC) in the latter. We describe a 5-year-old boy with acute lymphoblastic leukemia in remission, in whom CBDC developed after treatment with trimethoprim/sulfamethoxazole (cotrimoxazole). To our knowledge, this is the first reported case of possible drug-induced CBDC.
First Dermatology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey. drmuhterempolat@mynet.com
Muhterem
M
Polat
Nurdan
N
Lenk
Emin
E
Kürekçi
Pinar
P
Oztaş
Ferda
F
Artüz
Nuran
N
Alli
D000890:Anti-Infective Agents / Q000009:adverse effects*; D002675:Child, Preschool; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D007070:Immunoglobulin A; D015662:Trimethoprim, Sulfamethoxazole Drug Combination