[Regulation mechanism of variation in Plasmodium falciparum var gene family].
This is a review on the new progress in the study of regulation mechanism of Plasmodium falciparum Var gene family. The mutually exclusive expression system caused expression only one in 60 var genes while others were silenced. It was regulated on the transcriptional level mainly through three pathways: non-coding DNA elements, chromatin structure and perinuclear localization.
Zhang
Qing-feng
QF
Institute of Infectious Diseases and Vaccine Development, Tongji University, Shanghai 200092, China.
Pan
Wei-qing
WQ
D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics; D005786:Gene Expression Regulation; D017125:Genes, Protozoan / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics*
D004251:DNA Transposable Elements; D016054:DNA, Protozoan