Traditional management of chronic stable angina.
The clinical syndrome of chronic stable angina is an age-related condition that is one common manifestation of coronary artery disease (CAD). The presence of angina significantly affects quality of life when patients must limit their activities of daily living in an effort to prevent the occurrence of anginal attacks. In addition, patients are at risk for significant complications of CAD such as myocardial infarction, heart failure, stroke, and death. Therefore, treatment should focus not only on relief of symptoms and improvements in quality of life, but also on preventing disease progression and reducing the risk of complications from CAD. All patients should be instructed on the appropriate use of sublingual nitroglycerin for the immediate treatment of anginal episodes. Beta-blockers, calcium channel blockers, long-acting nitrate therapy, and ranolazine can prevent anginal symptoms. In addition, aggressive risk factor management, healthy lifestyle changes, antiplatelet agents such as aspirin, and angiotensin-converting enzyme inhibitors all should be used to prevent disease progression and occurrence of myocardial infarction or death. Many patients will be candidates for revascularization of the myocardium with either percutaneous coronary intervention or coronary artery bypass grafting for relief of symptoms as well as improvement in prognosis. Even after revascularization, patients may still require antianginal drug therapy. All patients undergoing revascularization should be guided to make appropriate lifestyle changes and to make concerted efforts to manage risk factors for CAD.
Department of Pharmacy, Boston Medical Center, Northeastern University School of Pharmacy, Boston, Massachusetts 02118, USA.
Toby C
TC
Trujillo
Paul P
PP
Dobesh
D000787:Angina Pectoris / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D009204:Myocardial Revascularization; D017410:Practice Guidelines as Topic; D011788:Quality of Life; D012307:Risk Factors