Total mesorectal excision (TME) with laparoscopic approach: 226 consecutive cases.
BACKGROUND
Total mesorectal excision (TME) of the rectum has been advocated as the gold surgical treatment of the middle and low third rectal cancer. Laparoscopy has gained acceptance among surgeons in the treatment of colon malignancies, while scepticism exists about laparoscopic TME in term of safety, and its oncological adequacy.


OBJECTIVE
To evaluate the impact of laparoscopic TME on surgical and oncological outcome in a group of consecutive unselected patients.


METHODS
226 unselected patients with rectal cancer underwent laparoscopic TME from January 1998 to August 2007. Patients staged cT3/4 cTxN+ were submitted to neoadjuvant treatment. Postoperative complications and oncological outcome were registered.


RESULTS
Mean distance of the tumour from the anal verge was 6.2+/-2 cm. 48.6% of patients were enrolled in "long-course" neoadjuvant chemo-radiotherapy (partial and complete response rates 72.4% and 20.1%, respectively). Surgical procedures were 202 anterior and 24 abdominal-perineal resections. Mean operative time 245.3+/-58.4 min, mean blood loss 203+/-176 mL. Conversion rate 6.1%. Thirty-days morbidity rate 31.8% without mortality. Anastomotic leaks rate was 16.8%. Reoperation rate 6.6%. Gastrointestinal recovery rate was 3.1+/-1.4 days and hospital stay 10.4+/-4.6 days. Concerning adequacy of oncologic resection, mean distance between tumour and margin of resection was 2.7+/-2 cm with a nodal sampling of 14.4+/-4.6. Six patients (2.6%) had a R1 margin. With a mean follow-up of 39.8 months non port-site metastases occurred. Local recurrence rate was 6.1%. Five years cumulative overall survival was 81% and disease-free survival was 70% (Kaplan-Meier method).


CONCLUSIONS
Laparoscopic approach for rectal tumour is a technically demanding procedure, but it is safe and it has the feature of an oncologic procedure.
Department of Surgery, Vita-Salute San Raffaele University, Milan, Italy.
Carlo
C
Staudacher
Saverio
S
Di Palo
Andrea
A
Tamburini
Andrea
A
Vignali
Elena
E
Orsenigo
D016063:Blood Loss, Surgical; D001803:Blood Transfusion / Q000706:statistics & numerical data; D013505:Digestive System Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000401:mortality / Q000628:therapy*; D012086:Reoperation / Q000706:statistics & numerical data