Synthesis and structure-immunosuppressive activity relationships of bakuchiol and its derivatives.
A series of derivatives of bakuchiol were synthesized and tested in vitro for their cytotoxicity, and inhibition of T cell proliferation and B cell proliferation. The data obtained provided preliminary structure-activity relationships of the compounds as immunosuppressive activity.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Road Zu Chong Zhi, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Hongli
H
Chen
Xiaolong
X
Du
Wei
W
Tang
Yu
Y
Zhou
Jianping
J
Zuo
Huijin
H
Feng
Yuanchao
Y
Li
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D019610:Cytoprotection / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D010636:Phenols; D003208:Concanavalin A; C012765:bakuchiol