[Protective effect of Jinhuang-1 on acute respiratory distress syndrome rats induced by oleic acid].
OBJECTIVE
To observe the protective effect of Jinhuang-1 (JH-1) on oleic acid-induced acute respiratory distress syndrome (ARDS) in rats and provide a basis to clinical application.


METHODS
Oleic acid was injected into the tail vein of rats and JH-1 were administered to rats. After four days, their blood were collected for the blood gas analysis. The superoxide dismutase (SOD), the malondialdehyde (MDA), nitic oxide (NO) content and the positive expression ratio of tumor necrosis factor-alpha (TNF-alpha) were determined. The pathological changes of microstructure of lung were observed.


RESULTS
The results demonstrated that JH-1 could significantly increase PO2, reduce PCO2 of oleic acid-induced ARDS rats, increase the superoxide dismutase, decrease the malondialdehyde, nitic oxide content and the positive expression ratio of TNF-alpha, and improve the histological destruction on lung.


CONCLUSIONS
JH-1 plays a protective role for ARDS rats induced by oleic acid. The mechanism is probably related to attenuating lipid peroxidation and decreasing NO content and the expression of TNF-alpha in lung.
Guangxi Medical University, Nanning 530021, China.
Dan
D
Zhu
Hua-Gang
HG
Liu
D000208:Acute Disease; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D001784:Blood Gas Analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D031239:Lonicera / Q000737:chemistry; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019301:Oleic Acid; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D031957:Ziziphus / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; C532969:jinhuang-1; D019301:Oleic Acid; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase