Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents.
Novel 2'-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Lak Shin
LS
Jeong
Jeong A
JA
Lee
Hea Ok
HO
Kim
Dilip K
DK
Tosh
Hyung Ryong
HR
Moon
Seung-Jin
SJ
Lee
Kang Man
KM
Lee
Yhun Y
YY
Sheen
Moon Woo
MW
Chun
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D007202:Indicators and Reagents; D009705:Nucleosides