Amnioinfusion in preterm PROM: effects on amnion and cord histology.
OBJECTIVE
To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).


METHODS
From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at <or=24.6 weeks, we excluded those who did not develop severe oligohydramnios (n=12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.


RESULTS
Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC.


CONCLUSIONS
A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.
Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy. anna.locatelli@unimib.it
A
A
Locatelli
M
M
Andreani
A
A
Ghidini
M
M
Verderio
A
A
Pizzardi
P
P
Vergani
C M
CM
Salafia
D000328:Adult; D000650:Amnion / Q000473:pathology*; D000653:Amniotic Fluid; D002823:Chorion / Q000473:pathology; D004847:Epithelial Cells; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D016104:Oligohydramnios / Q000473:pathology / Q000628:therapy; D021041:Placental Circulation / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012965:Sodium Chloride / Q000008:administration & dosage*; D014470:Umbilical Cord / Q000473:pathology*
D012965:Sodium Chloride