Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome.
Metabolic syndrome (MetS) comprises an array of metabolic risk factors including abdominal obesity, dyslipidemia, hypertension, and glucose intolerance. Individuals with MetS are at elevated risk for diabetes and cardiovascular disease. Central to the etiology of MetS is an interrelated triad comprising inflammation, abdominal obesity, and aberrations in fatty acid metabolism, coupled with the more recently recognized changes in metabolism during the postprandial period. We review herein preliminary evidence regarding the role of dietary n-3 polyunsaturated fatty acids in modulating each of the components of the triad of adiposity, inflammation, and fatty acid metabolism, with particular attention to the role of the postprandial period as a contributor to the pathophysiology of MetS.
Department of Human Health and Nutritional Sciences, Room 336-B Animal Science and Nutrition Building, University of Guelph, Guelph, ON N1G 2W1, Canada.
Lindsay E
LE
Robinson
Andrea C
AC
Buchholz
Vera C
VC
Mazurak
D050154:Adiposity / Q000502:physiology; D004032:Diet; D050171:Dyslipidemias / Q000178:diet therapy / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000517:prevention & control*; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000453:epidemiology / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000517:prevention & control*
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3