Formation of substituted pyrroles via an imine condensation/Aza-Claisen rearrangement/imine-allene cyclization process by MAOS.
A diverse collection of pyrroles has been prepared using a one-pot, domino aldehyde/amine condensation, [3,3]-aza-Claisen rearrangement, imine-allene cyclization strategy. This protocol was accelerated by microwave irradiation and provided very good levels of conversion after reacting for only 30 min.
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada. organ@yorku.ca
W Stacy
WS
Bremner
Michael G
MG
Organ
D000466:Alkadienes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D000466:Alkadienes; D001372:Aza Compounds; D007097:Imines; D011758:Pyrroles; C025947:propadiene