Status of terpenes as skin penetration enhancers.
Since its introduction, transdermal drug delivery has promised much but, in some respects has still to deliver on that initial promise, due to inherent limitations imposed by the percutaneous route. The greatest obstacle for transdermal delivery is the barrier property of the stratum corneum. Many approaches have been employed to breach the skin barrier, of which, the most widely used one is that of chemical penetration enhancers. Of the penetration enhancers, terpenes are arguably the most highly advanced and proven category and are classified as generally regarded as safe (GRAS) by the Food and Drug Administration. This paper presents an overview of the investigations on the feasibility and application of terpenes as sorption promoters for improved delivery of drugs through skin.
Aqil
Mohammed
M
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. aqilmalik@yahoo.com
Ahad
Abdul
A
Sultana
Yasmin
Y
Ali
Asgar
A
D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D006801:Humans; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects*; D013729:Terpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D013729:Terpenes