Network-centered view of coronary artery disease.
Systems biology is an emerging field that attempts to examine multiple elements of a biologic system using techniques such as expression microarrays or proteomics. The goal of systems biology is to detect all the elements of a system and create an interaction network between these so that the system can be explained under specified conditions. In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties.
Department of Medicine, University of California, Los Angeles, CA 90095-1679, USA. bbennett@mednet.ucla.edu
Brian J
BJ
Bennett
Casey E
CE
Romanoski
Aldons J
AJ
Lusis
D000818:Animals; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D008297:Male; D051379:Mice; D040901:Proteomics / Q000379:methods; D012680:Sensitivity and Specificity; D049490:Systems Biology