Primary squamous cell carcinoma of the thyroid: immunohistochemical profile and literature review.
BACKGROUND
Squamous cell carcinoma accounts for 1% of primary thyroid malignancies and is characterized by a rapidly unfavorable outcome.


METHODS
A 64-year-old woman presented with a painless mass in the left neck, coexisting with thyroid goiter. Total thyroidectomy with lymphadenectomy was performed and a primary thyroid squamous cell cancer was confirmed histologically after excluding any other possible primary malignancies. The tumor's immunohistochemical profile was explored using a large panel of antibodies. The tumor featured a positive immunoreaction to cytokeratins 7-19 and to squamous cell carcinoma antigen. Low-molecular-weight cytokeratins 5-6 and epithelial membrane antigen were also expressed. The neoplasm's proliferative index (Mib1) was 60%. No immunostaining was detected for cytokeratins 10-20, thyroglobulin, TTF-1, CD5, galectin-3 or p53.


CONCLUSIONS
This case of primary thyroid squamous cell carcinoma immunohistochemically profiled using a large panel of immunoreactions may offer useful information on the histological differentiation of thyroid squamous cell carcinoma from other (uncommon) thyroid carcinomas and the distinction between primary and secondary thyroid cancers.
Pathology Unit, Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, Padua, Italy.
Matteo
M
Fassan
Gianmaria
G
Pennelli
Maria Rosa
MR
Pelizzo
Massimo
M
Rugge
D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006042:Goiter / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008197:Lymph Node Excision; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins