Time and rate of sinus formation in pilonidal sinus disease.
BACKGROUND
and aims To elicit mechanisms and timing of sinus development, the role of age at onset of symptoms, symptomatic disease duration, and consecutive number of sinuses were investigated.


METHODS
Analysis of 1,962 medical records of patients admitted for primary surgical pilonidal sinus treatment.


RESULTS
Sinus number ranged from 1 to 16 (median 2), with chronic pilonidal disease showing more sinuses than acute disease (mean 2.6 vs 2.1 sinuses; p < 0.0001; Kolmogorov-Smirnov). Disease duration in chronic pilonidal disease was not linked to sinus formation (p = 0.98; Spearman). In acute pilonidal disease, duration was linked to the development of six sinuses per 1,000 symptomatic disease years (p = 0.0001; Spearman). A larger sinus number correlated with earlier onset of symptoms (p = 0.009; Spearman).


CONCLUSIONS
Long-standing chronic disease does not produce sinus per se. As sinus does not substantially arise during the course of symptomatic disease, there must be a time before the start of symptomatic disease when the sinus originates. These findings suggest that sinus can only be acquired up to a certain age, even if occupational exposure continues.
Doll
Dietrich
D
Department of Surgery, Military Hospital Berlin, Berlin, Germany. ddoll@gmx.de
Friederichs
Jan
J
Dettmann
Heidi
H
Boulesteix
Anne-Laure
AL
Duesel
Wolfgang
W
Petersen
Sven
S
D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D009017:Morbidity / Q000639:trends; D010864:Pilonidal Sinus / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors