Time-gated biological imaging by use of colloidal quantum dots.
The long (but not too long) fluorescence lifetime of CdSe semiconductor quantum dots was exploited to enhance fluorescence biological imaging contrast and sensitivity by time-gated detection. Significant and selective reduction of the autofluorescence contribution to the overall image was achieved, and enhancement of the signal-to-background ratio by more than an order of magnitude was demonstrated.
M
M
Dahan
T
T
Laurence
F
F
Pinaud
D S
DS
Chemla
A P
AP
Alivisatos
M
M
Sauer
S
S
Weiss