Halichonadin E, a dimeric sesquiterpenoid from the sponge Halichondria sp.
A new dimeric sesquiterpenoid with eudesmane and aromadendrane skeletons linked through a urea fragment, halichonadin E ( 1), was isolated from a marine sponge Halichondria sp., and the gross structure and relative configuration of 1 were elucidated on the basis of spectroscopic data. Halichonadin E ( 1) is the first hetero-dimeric sesquiterpenoid with eudesmane and aromadendrane skeletons linked through a urea fragment.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Shingo
S
Kozawa
Haruaki
H
Ishiyama
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D000818:Animals; D007564:Japan; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification*; D045789:Sesquiterpenes, Guaiane
D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D045789:Sesquiterpenes, Guaiane; C519959:aromadendrane; C529032:halichonadin E