Gastric extranodal marginal zone B-cell lymphomas of MALT type exclusively express Toll-like receptor 4 in contrast to other lymphomas infiltrating the stomach.
BACKGROUND
Development and growth of extranodal marginal zone B-cell lymphomas (eMZBCLs) of mucosa-associated lymphoid tissue (MALT) type are thought to be highly dependent on Helicobacter pylori and autoantigens. Receptors mediating these effects are not characterised so far. Toll-like receptors (TLRs) recognise bacterial proteins and autoantigens, which results in inflammatory reactions and influences tumour development and growth.


METHODS
TLR4, 5 and 9 expressions were evaluated by immunohistology and confocal microscopy in gastric eMZBCL in comparison to other lymphomas infiltrating the stomach.


RESULTS
TLR4 was exclusively expressed on the cell surface in all eMZBCL (n = 19) and not in chronic lymphocytic leukaemia (CLL, n = 12) or mantle cell lymphoma (MCL, n = 10). TLR5 was strongly expressed in CLL and weak in some eMZBCL (15 of 19), but not in MCL. TLR4, 5 and 9 were negative in all the three lymphoma entities.


CONCLUSIONS
Exclusive TLR4 expression may enable eMZBCL to interact with H. pylori and autoantigens. Blockade of TLR4 might be a new approach for therapy of eMZBCL of MALT type.
Pathologisches Institut, Universität Würzburg, Josef-Schneider-Street 2, 97080 Würzburg, Germany. patrick.adam@mail.uni-wuerzburg.de
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Adam
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Schmausser
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Göbeler-Kolve
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HK
Müller-Hermelink
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Eck
D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism* / Q000473:pathology*; D018613:Microscopy, Confocal; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
D051197:Toll-Like Receptor 4