[Cutaneous permeation comparison of Kechuan acupoint patch and power].
OBJECTIVE
To compare the cutaneous permeation of Kechuan acupoint patch and power, and evaluate the possibility of dosage form reform of Kechuan recipe.


METHODS
Take the Eugend and Ephedrine as the indexes, HPLC was employed to determine their contents, the pond with Franz diffusion were used to measured the cutaneous.


RESULTS
The permeation of Patch matched with Higuchi Equation. Take Eugend as the index, the permeation rate of total of Patch is 2.319 and 1.738 times of the powder, and 1.784 and 1.215 times of the powder with the Ephedrineas as index.


CONCLUSIONS
The permeation rate of Kechuan acupoint patch was more rapid than the powder. Moreover, the total quantity of permeation of patch was also more than the powder.
College of Pharmaceutics, HuNan University of Traditional Chinese Medicine and Drug, Changsha 410208, China. hequn88@126.com
Qun
Q
He
Gui-Ming
GM
Deng
Guang-Nin
GN
Yang
Li
L
Xu
Shi
S
Wang
D015669:Acupuncture Points; D000279:Administration, Cutaneous; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004809:Ephedrine / Q000008:administration & dosage / Q000493:pharmacokinetics; D005054:Eugenol / Q000008:administration & dosage / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D010539:Permeability; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D018927:Anti-Asthmatic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders; D005054:Eugenol; D004809:Ephedrine