Use of bispectral index to monitor depth of anesthesia in isoflurane-anesthetized dogs.
OBJECTIVE
To evaluate the correlation between the bispectral index (BIS) and end-tidal isoflurane (ET(ISO)) concentration and compare the use of 3 BIS sensor positions in dogs.


METHODS
6 adult dogs.


METHODS
Mechanically ventilated dogs received pancuronium, and depth of anesthesia was altered by increasing ET(ISO) concentration from 1.5% to 2.3% and 3.0%. The BIS, suppression ratio (relative percentage of isoelectric electroencephalographic waveforms), and signal quality index (SQI) were recorded at each ET(ISO) concentration for each of 3 BIS sensor positions (frontal-occipital, bifrontal, and frontal-temporal positions).


RESULTS
The BIS and ET(ISO) concentration were poorly correlated; regardless of sensor positioning, mean BIS values did not change significantly as ET(ISO) was increased. At 3% isoflurane, regardless of sensor positioning, there was an increase in suppression ratio coincident with BIS < 40 in some dogs, whereas paradoxic increases in BIS (> 60) were recorded in others. Furthermore, at 3.0% isoflurane, the SQI was significantly lower for the bifrontal sensor position (compared with values for the other positions), but low SQI values prevented recording of BIS values from the frontal-occipital sensor position in 2 dogs. Overall, BIS values derived from the 3 sensor positions did not differ.


CONCLUSIONS
In dogs, BIS values may not reflect changes in depth of isoflurane anesthesia in the absence of noxious stimulation. Of the 3 sensor positions, frontal-temporal positioning provided better correlation with changes in depth of anesthesia induced via changes in isoflurane concentrations. However, the sensor placements yielded similar results at SQI values > 50.
Campagnol
Daniela
D
Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
Teixeira Neto
Francisco J
FJ
Monteiro
Eduardo R
ER
Beier
Suzane L
SL
Aguiar
Antônio J A
AJ
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D004569:Electroencephalography / Q000379:methods / Q000662:veterinary*; D005260:Female; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male
D018685:Anesthetics, Inhalation; D007530:Isoflurane