Granular corneal dystrophy manifesting after radial keratotomy.
OBJECTIVE
To report a case of granular corneal dystrophy after radial keratotomy (RK).


METHODS
A 32-year-old man presented with white radial lines in both corneas. He had a history of uncomplicated RK in both eyes 8 years ago. Preoperative refraction had been OD -3.5-0.75 x 180 and OS -3.0-0.5 x 175. The cornea was reported to be clear on postoperative examinations.


RESULTS
Postoperative uncorrected visual acuity was OD 20/30 and OS 20/40. Best-corrected visual acuity was 20/25 in both eyes with OD -0.5-0.5 x 60 and OS -0.75-0.5 x 80. Slit-lamp examination revealed discrete well-demarcated whitish lesions with clear intervening stroma in the central anterior cornea consistent with granular dystrophy. Similar opacities were present within the RK incisions.


CONCLUSIONS
Production and deposition of such abnormal material could be due to keratocyte activation after RK or proliferation and migration of epithelial cells with a tendency to express abnormal keratoepithelin.
Labbafinejad Medical Center, Shaheed Beheshti University, Tehran, Iran. sepehrfeizi@yahoo.com
Sepehr
S
Feizi
Mohammad
M
Pakravan
Ali-Reza
AR
Baradaran-Rafiee
Shahin
S
Yazdani
D000328:Adult; D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007646:Keratotomy, Radial / Q000009:adverse effects*; D008297:Male; D009216:Myopia / Q000601:surgery; D010375:Pedigree; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D016212:Transforming Growth Factor beta / Q000235:genetics; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein