Modelling drug dissolution from controlled release products using genetic programming.
This study has investigated and compared genetic programming (GP) - a method of automatically generating equations that describe the cause-and-effect relationships in a system - and statistical methods for modelling two controlled release formulations--a matrix tablet and microspheres. With the improved GP models exhibiting comparable predictive power, as well as simpler equations in some cases, the results obtained indicate that GP can be considered as an effective and efficient method for modelling controlled release formulations.
Institute of Pharmaceutical Innovation, University of Bradford, Richmond Road, Bradford, West Yorkshire BD7 1DP, United Kingdom.
Duong Q
DQ
Do
Raymond C
RC
Rowe
Peter
P
York
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003198:Computer Simulation; D003692:Delayed-Action Preparations; D005544:Forecasting; D008863:Microspheres; D015233:Models, Statistical; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D013607:Tablets