Pasteurized autograft-prosthesis composite for distal femoral osteosarcoma.
BACKGROUND
We examined the survivorship and functional outcome of the pasteurized autograft-prosthesis composite for distal femoral osteosarcoma. We also evaluated complications including nonunion, loosening, bony resorption, infection, and fracture.


METHODS
We retrospectively reviewed 15 distal femoral osteosarcoma patients who underwent reconstructions using pasteurized autograft-prosthesis composite between 1993 and 2003.


RESULTS
No patient required graft removal during a minimum follow-up of 35 months (average 56 months; range 35-78 months). The average Musculoskeletal Tumor Society System (MTSS) functional score was 86%. Nonunion developed in five patients, and three of them subsequently showed loosening of the stem. No patient experienced infection or fracture.


CONCLUSIONS
Our data suggest that the pasteurized autograft-prosthesis composite could be an easily accessible alternative for the reconstruction of large skeletal defects in the distal femur because of the satisfactory functional outcome with a low rate of ultimate failure and complications in this study.
Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea.
Dae-Geun
DG
Jeon
Min Suk
MS
Kim
Wan Hyeong
WH
Cho
Won Seok
WS
Song
Soo-Yong
SY
Lee
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019637:Orthopedic Procedures / Q000379:methods*; D012516:Osteosarcoma / Q000175:diagnosis / Q000601:surgery*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012189:Retrospective Studies; D013977:Tibia / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome