Drug-induced hepatitis - morphological and ultrastructural aspects.
Frequency of drug-induced liver diseases is increasingly, more than 200 different drugs being incriminated in hepatic disorders. We performed a retrospective study on 65 cases of deaths due to drug intoxications and an experimental model of subacute hepatitis induced by acetaminophen. In our experimental model, we observed various histological lesions: granular degeneration, vascular congestion, lymphoplasmocyte infiltration, cytonecrosis. Histological criteria are not specifically, but very usefully, because based on these criteria we can suspect a drug etiology in hepatic disorders when any other cause is absent. Ultrastructural study of hepatocytes revealed some modifications, in addition to data provided by optical microscopy.
Enescu
Aurelia
A
Medical Emergency Clinic, University of Medicine and Pharmacy of Craiova, Romania. ancaenescus@yahoo.com
Mitruţ
P
P
Buteică
Elena
E
Stănoiu
B
B
Enescu
Anca
A
D000328:Adult; D002102:Cadaver; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D014617:Vacuoles / Q000473:pathology