Genetically engineered rat models for breast cancer.
Rat mammary cancers generally resemble many features of human breast cancer. With the recent developments in rat genetic engineering, the rat has become an excellent model system to study aspects of the molecular etiology of breast cancer. In this review, we describe the efforts to generate genetically engineered rat models for breast cancer.
Smits
Bart M G
BM
McArdle Lab for Cancer Research, University of Wisconsin - Madison, Madison, WI 53706, USA.
Cotroneo
Michelle S
MS
Haag
Jill D
JD
Gould
Michael N
MN
D000818:Animals; D030801:Animals, Genetically Modified; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D011905:Genes, ras; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D014162:Transfection
D018719:Erb-b2 Receptor Tyrosine Kinases