Updating of normal levels of copper, zinc and selenium in serum of pregnant women.
Selenium, copper and zinc status is important in pregnant women. The aim of this study was to establish updated normal ranges for these elements in serum of pregnant women from the Spanish region of Aragon, and to study variation in levels with respect to gestational period and maternal age. The study group consisted of 159 pregnant women who did not suffer from serious pathologies. These samples were classified into four gestational-period groups. Zn and Cu determinations were obtained by flame atomic absorption spectroscopy in a Perkin-Elmer 1100B apparatus, and Se was determined by electrothermal atomic absorption spectrometry with Zeeman correction, in a Perkin-Elmer 4110 ZL apparatus. The concentrations of Cu, Zn and Se averaged 73.61+/-43.67 microg/dL, 65.37+/-12.87 microg/dL and 99.59+/-21.74 microg/L, respectively. The Cu/Zn ratio increased from first trimester to the third trimester (2.07-3.49). There was no significant correlation between Zn and Se levels, but a significant correlation was found between Cu and Se levels (p<0.05) and between Cu and Zn levels (p<0.001). Serum Zn and Se levels decreased over gestation, while serum Cu concentrations increased; in all cases the variation occurred mostly in the first 3 or 4 months, with mean levels then remaining fairly stable until the end of pregnancy. Maternal age did not influence levels of any of the three metals.
Izquierdo Alvarez
Silvia
S
Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain. sizquierdo@salud.aragon.es
Castañón
Sandra García
SG
Ruata
Maria Luisa Calvo
ML
Aragüés
Elena Fuertes
EF
Terraz
Pilar Bocos
PB
Irazabal
Yolanda González
YG
González
Elena García
EG
Rodríguez
Beatriz García
BG
D000328:Adult; D003300:Copper / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012643:Selenium / Q000097:blood*; D015032:Zinc / Q000097:blood*
D003300:Copper; D012643:Selenium; D015032:Zinc