Stachybotrydial selectively enhances fibrin binding and activation of Glu-plasminogen.
Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60-120 microM) but not of Lys-plasminogen. Approximately 1.2-1.6 moles of [3H]stachybotrydial bound to Glu-plasminogen to exert such effects. The selective modulation of the Glu-plasminogen function by stachybotrydial may be related to alteration of its conformational status.
Department of Applied Biological Science, Tokyo Noko University, Fuchu-shi, Tokyo, Japan.
Masaaki
M
Sasaoka
Yasuko
Y
Wada
Keiji
K
Hasumi
D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D005337:Fibrin / Q000187:drug effects / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000302:isolation & purification / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D013191:Stachybotrys / Q000737:chemistry / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D001572:Benzofurans; D005343:Fibrinolytic Agents; D010446:Peptide Fragments; D013141:Spiro Compounds; C018998:lysyl-plasminogen; C094818:stachybotrydial; D005337:Fibrin; D010958:Plasminogen; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator