Bifunctional chelates for metal nuclides.
The use of ''non-standard'' metallic radionuclides continues to be an expanding field of investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles are all areas of active investigation for both diagnostic and therapeutic applications. All require a common variableaethe need for appropriate chelation chemistry for adequate sequestration of the metallic radionuclide that is equal to the intended application. A brief overview of the array of the chelation chemistry options available to researchers and the means for their selection is provided.
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA. martinwb@mail.nih.gov
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D002614:Chelating Agents / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D008670:Metals / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry
D002614:Chelating Agents; D008670:Metals; D011868:Radioisotopes; D019275:Radiopharmaceuticals