Distinctive role of central histamine H3 receptor in various orexigenic pathways.
Despite the well-established role of histamine as an anorexigenic neurotransmitter, the role of histamine H(3) receptors in feeding behavior is controversial. Herein we investigated the role of histamine H(3) receptor on several orexigenic agents in mice. Thioperamide (histamine H(3) receptor inverse agonist) inhibited neuropeptide Y- and nociceptin-induced hyperphagia but had no effect on U-50488 (opioid kappa-receptor agonist)-induced hyperphagia. In contrast, imetit (histamine H(3) receptor agonist) inhibited U-50488-induced hyperphagia but augmented neuropeptide Y-induced hyperphagia while it did not alter nociceptin-induced hyperphagia. These results indicate distinctive roles of histamine H(3) receptors in various orexigenic pathways.
Yoshimoto
Ryo
R
Tsukuba Research Institute, BANYU Pharmaceutical Co. Ltd, Tsukuba, Ibaraki 300-2611, Japan.
Kanatani
Akio
A
Tokita
Shigeru
S
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D017442:Histamine Agonists / Q000494:pharmacology; D054828:Histamine H3 Antagonists / Q000494:pharmacology; D006963:Hyperphagia / Q000139:chemically induced / Q000503:physiopathology*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y; D018847:Opioid Peptides; D010880:Piperidines / Q000494:pharmacology; D018100:Receptors, Histamine H3 / Q000187:drug effects / Q000378:metabolism*; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology; D000097629:Nociceptin
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D017442:Histamine Agonists; D054828:Histamine H3 Antagonists; D007093:Imidazoles; D009478:Neuropeptide Y; D018847:Opioid Peptides; D010880:Piperidines; D018100:Receptors, Histamine H3; D013890:Thiourea; D000097629:Nociceptin; C077430:imetit; C052075:thioperamide