Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics.
Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.
Aghajanova
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143-0132, USA. aghajanoval@obgyn.ucsf.edu
Hamilton
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Giudice
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D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002478:Cells, Cultured; D010064:Embryo Implantation / Q000235:genetics* / Q000502:physiology*; D004717:Endometrium / Q000502:physiology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D008954:Models, Biological; D011247:Pregnancy; D014599:Uterus / Q000033:anatomy & histology* / Q000378:metabolism / Q000502:physiology*
D015415:Biomarkers