Modulation of T-cell signalling by non-esterified fatty acids.
Polyunsaturated fatty acids (PUFAs) have been shown to be immunosuppressive. In particular, they can decrease important T-cell functions that may have a profound impact on the acquired immune response. Several mechanisms may explain the immunosuppressive properties of PUFAs. Here we review the mechanisms by which they interfere with T-cell activation. PUFAs affect lipid rafts composition and function that play an essential role in T-cell signalling. The possible physiological and pathological significances of this immunomodulation by PUFAs are discussed. Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states.
Department of Medicine and Centre de recherche Clinique Etienne-Le Bel, Faculty of Medicine, Université de Sherbrooke, QC, Canada.
Pascal
P
Brassard
Anis
A
Larbi
Amélie
A
Grenier
Frédérique
F
Frisch
Carl
C
Fortin
André C
AC
Carpentier
Tamàs
T
Fülöp
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated