Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides.
The alkylation reaction of 2,2'-diseleno and 4,4'-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
Martínez-Ramos
Federico
F
Departamento de Química Inorgánica, Escuela Nacional de Ciencias Biológicas, IPN Prolongación de Carpio y Plan de Ayala S/N, México DF, Mexico. f_martin57@hotmail.com
Salgado-Zamora
Hector
H
Campos-Aldrete
Maria Elena
ME
Melendez-Camargo
Estela
E
Márquez-Flores
Yazmín
Y
Soriano-García
Manuel
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D018036:Selenium Compounds