Presynaptic adenosine and P2Y receptors.
Adenine-based purines, such as adenosine and ATP, are ubiquitous molecules that, in addition to their roles in metabolism, act as modulators of neurotransmitter release through activation of presynaptic P1 purinoceptors or adenosine receptors (activated by adenosine) and P2 receptors (activated by nucleotides). Of the latter, the P2Y receptors are G protein-coupled, whereas the P2X receptors are ligand-gated ion channels and not covered in this review.
Department of Pharmacology, University of Porto, Porto, Portugal. jgoncalves@reit.up.pt
Jorge
J
Gonçalves
Glória
G
Queiroz
D000241:Adenosine / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D043682:Receptor, Adenosine A1 / Q000187:drug effects / Q000378:metabolism; D043683:Receptors, Adenosine A2 / Q000187:drug effects / Q000378:metabolism; D017661:Receptors, Presynaptic / Q000187:drug effects / Q000502:physiology*; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology*
D018377:Neurotransmitter Agents; D011687:Purines; D043682:Receptor, Adenosine A1; D043683:Receptors, Adenosine A2; D017661:Receptors, Presynaptic; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2; D000241:Adenosine