Successful management of aggressive periodontitis by regenerative therapy: a 3-year follow-up case report.
BACKGROUND
This case report presents a new treatment for localized aggressive periodontitis using surgery (papilla preservation technique [PPT]) combined with enamel matrix proteins and bioactive glass.


METHODS
Eight intrabony defects in a 19-year-old woman with localized aggressive periodontitis were treated by PPT and the application of enamel matrix proteins or enamel matrix proteins in combination with bioactive glass. Probing depth, gingival recession, and clinical attachment level (CAL) were evaluated at baseline, 6 and 12 months, and 2 and 3 years after treatment. The primary outcome variable was CAL.


RESULTS
After 3 years, the sites treated with enamel matrix proteins demonstrated a mean CAL change from 8.3 +/- 3.2 mm to 4.0 +/- 3.6 mm (P < 0.39), and the sites treated with enamel matrix proteins combined with bioactive glass showed a mean CAL change from 8.6 +/- 2.4 mm to 3.7 +/- 0.8 mm (P < 0.001).


CONCLUSIONS
In the present case of aggressive periodontitis, application of enamel matrix proteins with or without the addition of bioactive glass resulted in the successful treatment of intrabony defects.
Miliauskaite
Asta
A
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Homburg/Saar, Germany. asta.miliauskaite@gmx.de
Selimovic
Denis
D
Hannig
Matthias
M
D000208:Acute Disease; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002516:Ceramics; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005881:Gingiva / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods; D006801:Humans; D019647:Oral Surgical Procedures / Q000379:methods*; D017622:Periodontal Attachment Loss / Q000473:pathology; D010518:Periodontitis / Q000601:surgery*; D013524:Surgical Flaps
C022107:Bioglass; D018786:Bone Substitutes; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins