Anaphylaxis to vecuronium: the use of basophil CD63 expression as a possible screening tool to identify a safe alternative.
A 29-year-old woman with a history of anaphylaxis during anesthesia required diagnostic laparoscopic surgery for investigation of infertility. Previous laboratory investigations suggested that she had reacted to vecuronium, but she also had a specific IgE antibody to succinylcholine. The use of the basophil activation marker CD63 as a screening tool in selecting a safe muscle relaxant is presented.
Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff, Wales, UK. sudheerps@cf.ac.uk
Potteth S
PS
Sudheer
Ian R
IR
Appadurai
D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D000768:Anesthesia, General; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D001279:Atracurium / Q000031:analogs & derivatives; D001491:Basophils / Q000378:metabolism*; D003429:Cross Reactions; D003949:Diagnostic Techniques, Surgical; D005260:Female; D015870:Gene Expression; D005820:Genetic Testing; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D010980:Platelet Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D013390:Succinylcholine / Q000009:adverse effects; D060149:Tetraspanin 30; D014673:Vecuronium Bromide / Q000009:adverse effects*
D015703:Antigens, CD; C554586:CD63 protein, human; D003473:Neuromuscular Nondepolarizing Agents; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D001279:Atracurium; D014673:Vecuronium Bromide; D013390:Succinylcholine; C101584:cisatracurium