When is a pathology review indicated in endometrial cancer?
OBJECTIVE
Discrepancies may exist between an original pathology report and formal pathology review, with subsequent implications for treatment. We conducted a study of pathology review in endometrial cancer from a population-based study to identify areas of discrepancy and effect on treatment.


METHODS
This was a retrospective cohort study in Ontario, Canada from 1996 to 2000. We identified hysterectomy cases from patients with endometrial cancer that were subject to formal pathology review by a gynecologic pathologist at one of six tertiary care centers. Sarcomas and other rare histologic subtypes with fewer than five cases were excluded. We evaluated discrepancy between original pathology and review by demographics, stage, grade, and risk group. Four risk groups were defined: 1) low (stage I), 2) intermediate (stage I and II), 3) high-risk (stage I and II), and 4) advanced stage (all stage III and IV). Reclassification from one risk group to another upon pathology review represented a potential change in treatment. Factors associated with significant discrepancy were identified by a multivariable logistic regression model.


RESULTS
Formal pathology review was available on 450 cases. There were no differences by age, year, or hospital type. The overall discrepancy rate was 42.7% (95% confidence interval 38.2-47.3%). The intermediate-risk group had the highest rate of reclassification into another group (33.1%). The most significant rates of discrepancy were associated with endometrioid grades 2 and 3 tumors and stage IIA disease (39.8%, 50.9%, and 79.6%, respectively).


CONCLUSIONS
There was significant discrepancy between original pathology and formal review in endometrial cancer, with implications for guidelines on pathology review at a population level.


METHODS
III
Department of Gynecologic Oncology, M.D. Anderson Cancer Center, Houston, Texas, USA. jskwon@mdanderson.org
Janice S
JS
Kwon
Julie A
JA
Francis
Feng
F
Qiu
Michele M
MM
Weir
Helen C
HC
Ettler
D000368:Aged; D015331:Cohort Studies; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008485:Medical Audit; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging / Q000379:methods* / Q000592:standards; D015588:Observer Variation; D009864:Ontario; D010336:Pathology / Q000592:standards; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors