[A case of lymphocytic hypophysitis successfully treated with steroid pulse therapy].
Lymphocytic hypophysitis is an autoimmune disorder of the pituitary gland. We report a case of lymphocytic hypophysitis managed by high dose methylprednisolone pulse therapy and review the literature. A 61-year-old woman presented with severe headache. Magnetic resonance imaging (MRI) revealed a contrast enhancing pituitary mass. The patient underwent endonasal-transsphenoidal surgery of the pituitary lesion under the diagnosis of a non-secreting pituitary adenoma. Intraoperative histological findings suggested an inflammatory lesion and we performed subtotal resection of the mass. Histopathological examination confirmed the diagnosis of lymphocytic hypophysitis. Postoperatively, she received methylprednisolone pulse therapy and her severe headache resolved. This case report suggests that methylprednisolone pulse therapy may improve the clinical symptoms of lymphocytic hypophysitis.
Department of Neurosurgery, Yodogawa Christian Hospital, 2-9-26 Awaji, Higashiyodogawa-ku, Osaka-city 533-0032, Japan.
Atsushi
A
Uyama
Masato
M
Sasaki
Mitsuru
M
Ikeda
Masahiro
M
Asada
Kazuhiro
K
Teramura
Mayumi
M
Tachibana
D000236:Adenoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008218:Lymphocytosis / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D010900:Pituitary Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D020551:Pulse Therapy, Drug
D008775:Methylprednisolone