Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-beta-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient.
A case of bla(VIM-1) producing E. cloacae disseminated infection in a patient submitted to orthotopic liver transplantation is described. Synergism between colistin, rifampin and imipenem was studied in vitro and this combination of three drugs was used to treat E. cloacae infection. The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy.
Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. c.tascini@ao-pisa.toscana.it
C
C
Tascini
L
L
Urbani
G
G
Biancofiore
G M
GM
Rossolini
A
A
Leonildi
G
G
Gemignani
M L
ML
Bindi
C
C
Mugnaioli
F
F
Filipponi
F
F
Menichetti
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003091:Colistin / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D016972:Enterobacter cloacae / Q000201:enzymology; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage*; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D015378:Imipenem; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases; D012293:Rifampin; D003091:Colistin