Auditory event-related potentials in non-demented patients with sporadic amyotrophic lateral sclerosis.
OBJECTIVE
To investigate the presence of sub-clinical cognitive dysfunction in non-demented patients with amyotrophic lateral sclerosis (ALS) using auditory event-related potentials (ERPs).


METHODS
Ten subjects with ALS and 10 age- and sex-matched controls performed a passive three-stimulus paradigm with standard (80%), deviant (16%) and distracter (4%) stimuli. To quantify the mismatch component, the evoked response to the standard tones was subtracted from the corresponding deviant stimuli and novel response; the P3a component was obtained by subtracting the response to the standard tone from that to the novel stimuli. The amplitude and latency for the N1 component obtained with the standard stimuli were also measured. Clinical features, disability, cognitive status and depression were evaluated with standardised scales.


RESULTS
There were no significant differences between patients and controls for latencies, while the N1, P3a and MMN (obtained by the subtraction Novel-Standard) were of lower amplitude in patients than in controls. In the patient group, the P3a latency correlated with months from disease onset and symptoms severity, measured with the amyotrophic lateral sclerosis severity scale.


CONCLUSIONS
Our findings confirm the hypothesis of a sub-clinical cognitive impairment in non-demented ALS patients, suggesting pathological involvement beyond the motor areas.


CONCLUSIONS
ERPs seem to be a promising technique to detect the possible impairment of extra-motor sub-clinical dysfunction in ALS, and an appropriate technique for the cognitive follow-up, as passive tasks, not requiring motor responses, are particularly adequate in a disorder leading to severe loss of motor function.
Department of Neurology and Neurorehabilitation, San Raffaele Turro, San Raffaele Scientific Institute, Via Stamira d'Ancona 20, 20127 Milan, Italy. raggi.alberto@hsr.it
Alberto
A
Raggi
Monica
M
Consonni
Sandro
S
Iannaccone
Daniela
D
Perani
Michele
M
Zamboni
Barbara
B
Sferrazza
Stefano F
SF
Cappa
D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D016022:Case-Control Studies; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D013223:Statistics as Topic