Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses.
The consensus sequence of endogenous lentiviral elements in the genome of European rabbits (RELIK) was used to extend a model of conserved lentiviral and betaretroviral surface envelope glycoprotein (SU) inner domain structures. Here it is shown that nearly all the inner domain elements of human and simian immunodeficiency virus gp120 mediating conformational changes upon CD4 binding were conserved in the SU of RELIK. Many of these inner domain elements and a carboxy-terminal region outside the gp120 core are also conserved in the SU of other lentiviruses and betaretroviruses, suggesting conserved mechanisms of SU conformational changes induced by receptor binding.
Department of Protein Engineering, Genentech Inc, South San Francisco, CA 94080, USA. ihotzel@gene.com
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Hötzel
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D030121:Betaretrovirus / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D017124:Conserved Sequence; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016086:Lentivirus / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011817:Rabbits; D016415:Sequence Alignment; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D008562:Membrane Glycoproteins; D014759:Viral Envelope Proteins; C069623:gp120 protein, Simian immunodeficiency virus