In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.
We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.
Argenta
Juliana S
JS
Campus UFSM, Prédio 20, Sala 4139, 97105-900 Santa Maria, RS, Brazil. santurio@smail.ufsm.br.
Santurio
Janio M
JM
Alves
Sydney H
SH
Pereira
Daniela I B
DI
Cavalheiro
Ayrton S
AS
Spanamberg
Andréia
A
Ferreiro
Laerte
L
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001938:Brazil; D004283:Dog Diseases / Q000382:microbiology; D004285:Dogs; D004357:Drug Synergism; D006734:Horse Diseases / Q000382:microbiology; D006736:Horses; D007239:Infections / Q000382:microbiology / Q000662:veterinary; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009281:Naphthalenes / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D011775:Pythium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000077291:Terbinafine; D065819:Voriconazole