Birth size and accelerated growth during infancy are associated with increased odds of childhood overweight in Mexican children.
OBJECTIVE
The associations of birth size, rate of growth during infancy, and odds of childhood overweight have not yet been thoroughly investigated in contemporary cohorts in low- and middle-income countries. The primary aim of this study was to evaluate the influence of birth size (using body mass index at birth) and accelerated growth during infancy (defined as upward growth curve percentile crossing between birth and age 1 year) on the odds of childhood overweight. A secondary goal was to characterize the sociodemographic correlates of accelerated growth during infancy.


METHODS
Observational prospective cohort.


METHODS
Participants were 163 children and their mothers living in semiurban Mexico who were originally recruited between 1997 and 2000 and followed until 2005.


METHODS
Primary outcome was childhood overweight (as assessed by body mass index). Secondary outcome was accelerated growth during infancy.


METHODS
Multivariate linear regression and logistic regression were used to determine the associations among birth size, accelerated growth, and childhood overweight.


RESULTS
Increased size at birth and accelerated growth during the first year of life increased the odds of childhood overweight (odds ratio [OR] 7.62, P<0.0005 and OR 2.23, P<0.05, respectively). The effect of accelerated growth on odds of childhood overweight varied by size at birth (OR for interaction term 0.63, P<0.05). Living in a "dual burden" household, where the child was underweight at birth and the mother was overweight 4 to 6 years after birth, was associated with accelerated growth during the first year of life.


CONCLUSIONS
In a sample of Mexican children living in poverty, accelerated growth during infancy was associated with increased odds of childhood overweight among small and normal-sized babies. Among large babies, accelerated growth did not appear to pose an additional risk for overweight beyond that of high birth weight. Upward growth curve percentile crossing in infancy may be predictive of future childhood overweight status, particularly among smaller infants.
Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516-2524, USA. jessejonessmith@unc.edu
Jessica C
JC
Jones-Smith
Lia C H
LC
Fernald
Lynnette M
LM
Neufeld
D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008800:Mexico; D015999:Multivariate Analysis; D050177:Overweight / Q000209:etiology*; D011203:Poverty; D011446:Prospective Studies; D012044:Regression Analysis; D012959:Socioeconomic Factors; D013383:Suburban Population