Fetal adiponectin and resistin in correlation with birth weight difference in monozygotic twins with discordant growth.
BACKGROUND
Various studies have demonstrated an increased risk for adult diseases in newborns born small-for-gestational-age (SGA). Adiponectin and resistin can be detected in cord blood and are suggested to affect insulin resistance (IR). This might represent a link between metabolic syndrome and SGA birth.


METHODS
We investigated the relationship between the adipocytokines and inter-twin birth weight (BW) difference of 31 monozygotic twins with twin-twin transfusion syndrome; in 14 twin pairs BW difference was >15% (1 SGA twin, 1 appropriate-for-gestational-age, AGA, twin).


RESULTS
BW and length of all patients were positively related to adiponectin (r = 0.57; p < 0.0001; r = 0.47; p < 0.0001) and to resistin (r = 0.31; p < 0.01; r = 0.35; p < 0.01). In 71% (10/14), the SGA twins showed lower adiponectin concentrations than their AGA co-twins (only 6/14 for resistin). To correct for gestational age we calculated the relationship between the intrapair differences (Delta) of BW and Delta of the hormones. We found Delta BW positively correlated with adiponectin (r = 0.55; p < 0.001) but not with resistin (r = 0.22; p = 0.2). Delta adiponectin was positively correlated with Delta resistin (r = 0.45; p < 0.01).


CONCLUSIONS
These data demonstrate that adiponectin and resistin levels are associated with BW with only adiponectin levels being reduced in SGA children independently of gestational age. Prenatally different metabolic status between the twins might predispose the SGA twin to develop IR later in life.
Department of Paediatrics, University of Bonn, Bonn, Germany. gohlke-bonn@t-online.de
Bettina C
BC
Gohlke
Peter
P
Bartmann
Rolf
R
Fimmers
Agnes
A
Huber
Kurt
K
Hecher
Christian L
CL
Roth
D052242:Adiponectin / Q000097:blood; D001724:Birth Weight; D005260:Female; D005330:Fetofetal Transfusion / Q000097:blood* / Q000235:genetics; D006130:Growth Disorders / Q000097:blood* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood; D008297:Male; D011247:Pregnancy; D052243:Resistin / Q000097:blood*; D014430:Twins, Monozygotic / Q000097:blood*
C499918:ADIPOQ protein, human; D052242:Adiponectin; C499624:RETN protein, human; D052243:Resistin