Autofluorescence of congenital hypertrophy of the retinal pigment epithelium.
OBJECTIVE
To describe the autofluorescence features of CHRPE.


METHODS
Noncomparative case series.


METHODS
Thirteen consecutive eyes with CHRPE.


METHODS
: CHRPE was studied with fundus photography and autofluorescence. Autofluorescence was judged relative to the surrounding retinal pigment epithelium.


METHODS
Autofluorescence features of CHRPE.


RESULTS
The mean CHRPE basal dimension was 4.75 mm and the tumor location was between the macular and equator (n = 10) or equator and ora serrata (n = 3). Overall, CHRPE show hypoautofluorescence in every case and was classified as trace (n = 1), moderate (n = 6), or marked (n = 6) hypoautofluorescence. Compared to the central portion of CHRPE, the margin showed isoautofluorescence (n = 8) or trace hyperautofluorescence (n = 5). There were eight lesions with lacunae and this feature generally showed trace to moderate hyperautofluorescence (n = 6). A nonpigmented halo was present surrounding six lesions, generally showing trace hyperautofluorescence (n = 3). A pigmented halo was present surrounding eight lesions, usually showing isoautofluorescence (n = 6).


CONCLUSIONS
CHRPE shows striking hypoautofluorescence and this correlates with known histopathologic evidence of lack of lipofuscin in the retinal pigment epithelium of CHRPE. The lacunae showed general mild hyperautofluorescence that might correlate with scleral autofluorescence.
Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. carol.shields@shieldsoncology.com
Carol L
CL
Shields
Cesare
C
Pirondini
Carlos
C
Bianciotto
Sarah A
SA
Harmon
Jerry A
JA
Shields
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D006984:Hypertrophy / Q000151:congenital; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010781:Photography; D010857:Pigment Epithelium of Eye / Q000378:metabolism / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000378:metabolism
D008062:Lipofuscin