Genetics of melanoma tumorigenesis.
Melanoma therapy is moving away from combinatorial approaches and towards newer targeted strategies. With the identification of mutations in various RAS pathway genes, there are now tremendous opportunities to bring inhibitors of RAS signalling to the clinical arena.
Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA.
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Singh
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Lin
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TL
Hocker
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Tsao
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics; D008545:Melanoma / Q000188:drug therapy / Q000235:genetics*; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics
D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D018631:ras Proteins