Recent progress in the development of derivatization reagents having a benzofurazan structure.
Chemical derivatization is often used to enhance the detectability of the target compounds and to improve the separation efficiency in high-performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan structure, namely, the fluorogenic reagents, water-soluble reagents, reagents for the analysis of peptides and proteins, and reagents for mass spectrometric detection. The application of these reagents to bio-samples is also briefly described.
Santa
Tomofumi
T
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. santa@mol.f.u-tokyo.ac.jp
Fukushima
Takeshi
T
Ichibangase
Tomoko
T
Imai
Kazuhiro
K
D001583:Benzoxazoles / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005456:Fluorescent Dyes / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure
D001583:Benzoxazoles; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; C020160:benzofurazan