Injectability evaluation of tricalcium phosphate bone cement.
Calcium phosphate cements are biomaterials made from a mixture of calcium phosphate powder in aqueous solutions that forms a paste that reacts at the body temperature and hardens as a result of precipitation reactions. These cements are commonly used in dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The challenge consists in formulating an injectable paste by additives incorporation. In this work, three different additives (carboxymethylcellulose, agar polymer and sodium alginate) were incorporated to tricalcium phosphate, in concentrations of 0.4, 0.8, 1.6, 3.2 and 6.4 wt.%. Injectability was evaluated through a new method developed for this purpose. Results showed that it was possible to obtain injectable compositions of alpha-tricalcium phosphate cement. It was verified that the injectability depends on the rheological behavior of the pastes and injection time. In this study, pastes with viscosity suitable for good homogenization and injection were obtained.
Department of Materials Science and Engineering, Federal University of Rio Grande do Sul, Avenida Osvaldo Aranha, 99, 705c, Centro, Porto Alegre, RS 90620-000, Brazil.
Hugo Leonardo Rocha
HL
Alves
Luis A
LA
Dos Santos
Carlos P
CP
Bergmann
D000362:Agar / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D019245:Compressive Strength; D004305:Dose-Response Relationship, Drug; D004867:Equipment Design; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D012212:Rheology; D013499:Surface Properties; D013997:Time Factors; D014783:Viscosity
D000464:Alginates; D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D000362:Agar; C018392:tricalcium phosphate; D002266:Carboxymethylcellulose Sodium