Inhibition of TGF-beta expression: a novel role for thiazolidinediones to implement renoprotection in diabetes.
Actual strategies to delay progression of diabetic nephropathy provide imperfect protection when started late in the course of the disease. Ohtomo et al. now demonstrate that thiazolidinedione treatment was associated with a remarkable improvement in proteinuria and renal function, offering a new potential treatment for diabetic nephropathy.
Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo-Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
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Remuzzi
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology; D045162:Thiazolidinediones / Q000627:therapeutic use*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D045162:Thiazolidinediones; D016212:Transforming Growth Factor beta