Breaking the cycle of translation.
In a recent issue of Molecular Cell, Trobro and Aqvist (2007) reported mechanistic insight into release factor-induced peptide hydrolysis. Now, in this issue, the Green research group establishes unexpected complexity in decoding translation stop codons (Youngman et al., 2007).
Rife
Jason P
JP
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. jason.rife@vcu.edu
Culver
Gloria M
GM
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018388:Codon, Terminator / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D010303:Paromomycin / Q000494:pharmacology; D010454:Peptide Termination Factors / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000187:drug effects
D000900:Anti-Bacterial Agents; D018388:Codon, Terminator; D010454:Peptide Termination Factors; D010455:Peptides; D012346:RNA, Transfer, Amino Acyl; D010303:Paromomycin