Genetics of migraine and pharmacogenomics: some considerations.
Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response.
Department of Diagnostic Sciences, Medical Genetics Section, 2nd School of Medicine, University of Rome La Sapienza, I-00185, Rome, Italy. maria.piane@uniroma1.it
Maria
M
Piane
Patrizia
P
Lulli
Ivano
I
Farinelli
Simona
S
Simeoni
Sergio
S
De Filippis
Francesca Romana
FR
Patacchioli
Paolo
P
Martelletti
D000700:Analgesics / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics
D000700:Analgesics