[HLA-A24: risk factor in proliferante diabetic retinopathy].
OBJECTIVE
Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)-A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR.


METHODS
We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques.


RESULTS
The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001).


CONCLUSIONS
HLA-A24 is not a protective factor for PDR, but is a risk factor of its development.
Hospital General, Medina del Campo, Valladolid, España. vasensio@hmdc.sacyl.es
V M
VM
Asensio-Sánchez
B
B
Rodríguez-Delgado
E
E
García-Herrero
V
V
Cabo-Vaquera
C
C
García-Loygorri
D000368:Aged; D003930:Diabetic Retinopathy / Q000097:blood* / Q000209:etiology; D005260:Female; D015234:HLA-A Antigens / Q000097:blood*; D059871:HLA-A24 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D015234:HLA-A Antigens; D059871:HLA-A24 Antigen