Clinical and molecular characteristics of staphylococcal skin abscesses in children.
Forty-nine children with skin abscesses (36 methicillin-resistant Staphylococcus aureus and 13 methicillin-susceptible S. aureus) exhibited similar disease severity. Both pathogen groups were pulse field type USA300, multilocus sequence type 8, and possessed Panton-Valentine leukocidin genes. Related microbial genetic architecture may account for similarities in disease severity despite differences in antibiotic susceptibility.
Department of Pediatrics, Division of Infectious Diseases, State University of New York, Buffalo, New York, USA. hfaden@upa.chob.edu
Howard
H
Faden
Rebecca
R
Rose
Alan
A
Lesse
Celeste
C
Hollands
Diane
D
Dryja
Philip L
PL
Glick
D000038:Abscess / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002876:Chromosomes, Bacterial / Q000235:genetics; D017714:Community-Acquired Infections / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000235:genetics; D008245:Lysophospholipase / Q000235:genetics; D008297:Male; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012720:Severity of Illness Index; D013207:Staphylococcal Skin Infections / Q000145:classification / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity
D007956:Leukocidins; D008245:Lysophospholipase