Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action.
Familial glucocorticoid deficiency (FGD), otherwise known as hereditary unresponsiveness to ACTH, is a rare autosomal recessive disease characterized by glucocorticoid deficiency in the absence of mineralocorticoid deficiency. Mutations of the ACTH receptor, also known as the melanocortin-2 receptor (MC2R), account for approximately 25% of FGD cases. More recently a second gene, MRAP (melanocortin-2 receptor accessory protein), was identified and found to account for a further 15-20%. MRAP encodes a small single transmembrane domain protein, which is essential in the trafficking of the MC2R to the cell surface. In this review, we will firstly summarize the clinical presentation and genetic aetiology of this condition. Secondly, we will discuss how the discovery of MRAP has enhanced our understanding of the mechanisms of ACTH/MC2R action. Finally, we will explore future developments in this field.
Centre for Endocrinology, William Harvey Research Institute, St. Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK.
L F
LF
Chan
A J L
AJ
Clark
L A
LA
Metherell
D000307:Adrenal Gland Diseases / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D005938:Glucocorticoids / Q000172:deficiency*; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D044103:Receptor, Melanocortin, Type 2 / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
D005938:Glucocorticoids; D044103:Receptor, Melanocortin, Type 2; D000324:Adrenocorticotropic Hormone