Microarray-based expression profiling and informatics.
Microarray-based expression profiling is a powerful technology for studying biological mechanisms and for developing clinically valuable predictive classifiers. The high-dimensional read-out for each sample assayed makes it possible to do new kinds of studies but also increases the risks of misleading conclusions. We review here the current state-of-the-art for design and analysis of microarray-based investigations.
Simon
Richard
R
National Cancer Institute, 9000 Rockville Pike, MSC 7434, Bethesda, MD 20892, United States. rsimon@nih.gov
D000465:Algorithms; D001709:Biotechnology; D019295:Computational Biology; D020869:Gene Expression Profiling / Q000145:classification / Q000706:statistics & numerical data*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000145:classification / Q000706:statistics & numerical data*; D010641:Phenotype