Xylarinic acids A and B, new antifungal polypropionates from the fruiting body of Xylaria polymorpha.
Two new polypropionates designated as xylarinic acids A and B were isolated from the fruiting body of Xylaria polymorpha. Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Both compounds displayed significant antifungal activity against plant pathogenic fungi Pythium ultinum, Magnaporthe grisea, Aspergillus niger, Alternaria panax, and Fusarium oxysporium, whereas they did not show antibacterial and cytotoxic effect.
Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Korea.
Yun-Woo
YW
Jang
In-Kyoung
IK
Lee
Young-Sook
YS
Kim
Sangku
S
Lee
Ho-Jae
HJ
Lee
Seung Hun
SH
Yu
Bong-Sik
BS
Yun
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
C527231:2,4,6-trimethyl-2-octenoic acid; C527230:4,6,8-trimethyl-2,4-decadienoic acid; D000935:Antifungal Agents; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue