Malondialdehyde levels in adult attention-deficit hyperactivity disorder.
OBJECTIVE
To evaluate the biochemical basis of adult attention-deficit hyperactivity disorder (A-ADHD), we compared lipid peroxidation status in the plasma of A-ADHD patients, and that of control subjects without A-ADHD by quantifying the levels of malondialdehyde (MDA), an end product of fatty acid oxidation. We aimed to examine the association between MDA and A-ADHD.


METHODS
The study comprised 20 A-ADHD patients from Gaziantep University Sahinbey Research Hospital Psychiatry Clinic, diagnosed by 2 psychiatrists (H.A.S. and S.S.) according to the Turkish version of the adult ADD/ADHD DSM-IV-Based Diagnostic Screening and Rating Scale, and 21 healthy volunteers. Malondialdehyde levels were measured in plasma samples of both study groups.


RESULTS
The mean (standard deviation [SD]) MDA levels in patients (2.44 [0.84] nmol/mL) were significantly higher than those of control subjects (0.36 [0.20] nmol/mL) (t=11.013, df=39, p<0.01). MDA levels were correlated with overall number of criteria met (n=20, p=0.01, Ro=0.56) and total hyperactivity/impulsivity score (n=20, p=0.02, Ro=0.51).


CONCLUSIONS
The fact that MDA levels were increased in A-ADHD could be an indication of increased oxidative stress in this disease. We suggest that such changes may have a pathological role in A-ADHD. This is the first study evaluating the MDA levels in A-ADHD, and our findings may provide a scientific guide for the further clinical enzymologic and biochemical studies on this disorder.
Bulut
Mahmut
M
Bulut, Selek, Savas-Psychiatry Department, Gaziantep University Sahinbey Research Hospital, Gaziantep, Turkey.
Selek
Salih
S
Gergerlioglu
H Serdar
HS
Savas
Haluk A
HA
Yilmaz
H Ramazan
HR
Yuce
Murat
M
Ekici
Giyasettin
G
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D017382:Reactive Oxygen Species; D012720:Severity of Illness Index
D017382:Reactive Oxygen Species; D008315:Malondialdehyde