Dilation of renal artery stenosis after administration of losartan.
Transluminal angioplasty with a balloon catheter is effective to dilate renal artery stenosis (RAS) caused by fibromuscular dysplasia (FMD), but lesions resistant to the angioplasty exist. In this report, we describe the case of a young woman with RAS of FMD that was difficult to dilate even by cutting-balloon angioplasty. To facilitate the formation of a smooth intimal covering at the site of angioplasty, we administered losartan, an angiotensin receptor blocker, for 4 months after the angioplasty. Although re-stenosis was detected at 5 months after the angioplasty, the normotensive state continued without antihypertensives and the re-stenosis gradually dilated afterwards. The present case suggests the possibility of remodeling the renal artery during the normotensive state by administering losartan after the angioplasty.
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. mtanemoto-tky@umin.ac.jp
Masayuki
M
Tanemoto
Kei
K
Takase
Takayuki
T
Yamada
Akihiro
A
Satoh
Takaaki
T
Abe
Sadayoshi
S
Ito
D000328:Adult; D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D005352:Fibromuscular Dysplasia / Q000150:complications*; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications* / Q000209:etiology; D019808:Losartan / Q000627:therapeutic use*; D012078:Renal Artery Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D017211:Treatment Failure
D000959:Antihypertensive Agents; D019808:Losartan