[Metabolic control and insulin administration in a girl with Turner syndrome and type 1 diabetes during long-term growth hormone therapy].
Many surveys have indicated that short stature affects at least 95% of all patients with Turner syndrome (TS). It is also clear that growth hormone (GH) therapy can accelerate the physical development in girls with TS. According to some clinical experience diabetes type 1 may be considered as a contraindication for GH therapy leading to low efficacy and high risk of late complications due to hyperglycaemia and elevated IGF-1 level. We present the results of growth hormone therapy on the metabolic control in a girl with TS and type 1 diabetes treated with continuous subcutaneous insulin infusion. The parameters of metabolic control and insulin doses were compared before and after introducing GH therapy. The correct diurnal glycemia profile was obtained after 4-fold increase of basal insulin and 2-fold increase of the total daily dose. The acceleration of growth was observed during 3.5-year therapy and average linear growth velocity was 7 cm/year. Growth hormone administration in children with Turner syndrome and type 1 diabetes can be efficacious and safe.
Department of Pediatric Diabetology, Neonatology and Birth Defects, The Medical University of Warsaw, ul. Działdowska 1, Warsaw, Poland. epankowska@interia.pl
Ewa
E
Pankowska
Mieczysław
M
Szalecki
Tomasz E
TE
Romer
D000293:Adolescent; D001786:Blood Glucose / Q000187:drug effects*; D001827:Body Height / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D019382:Human Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D011994:Recombinant Proteins / Q000008:administration & dosage*; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D011994:Recombinant Proteins; D019382:Human Growth Hormone