Effects of progesterone on FSH-stimulated indomethacin ulcers in rats.
OBJECTIVE
To investigate whether the balance between progesterone and FSH levels has a role in ulcer formation/inhibition.


METHODS
Animal study.


METHODS
Ataturk University, Faculty of Medicine, Laboratory of Pharmacology Department.


METHODS
One hundred thirty-two female Albino Wistar rats.


METHODS
Ovariectomy. Chronic administration of progesterone and estrogen to ovariectomized rats. Acute administration of progesterone to ovariectomized rats. Acute administration of progesterone and FSH to intact rats. Combined administration of mifepristone with progesterone or FSH to intact rats. Indomethacin administration to all rats.


METHODS
Gastric ulcer areas as mm(2).


RESULTS
Indomethacin-induced ulcers were significantly higher in ovariectomized rats than in intact rats. Chronic progesterone (1 mg/kg) inhibited gastrointestinal system ulcers by 51.2%, whereas 2 and 5 mg/kg chronic progesterone and 1, 2, and 5 mg/kg chronic estrogen were not effective. Acute progesterone (5 mg/kg) increased indomethacin ulcers significantly in ovariectomized rats. FSH increased indomethacin ulcers significantly. In addition, progesterone increased indomethacin ulcers significantly in intact rats. Mifepristone antagonized the ulcerogenic effects of FSH and progesterone.


CONCLUSIONS
Our data suggest that progesterone is not an antiulcer hormone, and produces ulcers via its own receptor. In addition, FSH may produce ulcerogenic effects via progesterone receptors. The low doses of progesterone (inhibits endogenous FSH) cannot stimulate its own receptors sufficiently for ulcer formation and prevent the ulcerogenic effects of FSH by decreasing FSH concentration.
Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Bunyamin
B
Borekci
Elif
E
Cadirci
Abdulmecit
A
Albayrak
Halis
H
Suleyman
Zekai
Z
Halici
Sedat
S
Kadanali
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006727:Hormone Antagonists / Q000494:pharmacology; D007213:Indomethacin; D015735:Mifepristone / Q000494:pharmacology; D010052:Ovariectomy; D011374:Progesterone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control
D004967:Estrogens; D006727:Hormone Antagonists; D015735:Mifepristone; D011374:Progesterone; D005640:Follicle Stimulating Hormone; D007213:Indomethacin