Non-covalent interactions of a drug molecule encapsulated in a hybrid silica gel.
The drug molecule Propranolol has been encapsulated by a sol-gel process in an organic-inorganic hybrid matrix by in-situ self-assembly; the 2D HETCOR solid state NMR spectroscopy provides direct proof of the intimate spatial relationship between the host matrix and guest drug molecules.
Institut für Physikalische Chemie and Graduate School of Chemistry, Westfälische Wilhelms-Universität, Corrensstrasse 36, Münster, Germany.
Geo
G
Paul
Stefan
S
Steuernagel
Hubert
H
Koller
D002214:Capsules / Q000737:chemistry; D005782:Gels; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D011433:Propranolol / Q000737:chemistry*; D012015:Reference Standards; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors
D002214:Capsules; D005782:Gels; D012822:Silicon Dioxide; D011433:Propranolol