Seizures and altered mental status after lamotrigine overdose.
Lamotrigine is a commonly prescribed anticonvulsant medication. It is an infrequently reported agent of intentional acute ingestion to poison centers. The spectra of clinical effects of lamotrigine in acute overdose are not well established. We report a case of acute ingestion of lamotrigine and ethanol that resulted in coma requiring ventilatory support, paradoxic seizure activity, and mild rhabdomyolysis.
Schwartz
Michael D
MD
Georgia Poison Center/Emory University School of Medicine, Atlanta, Georgia, USA. aeo8@cdc.gov
Geller
Robert J
RJ
D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D003243:Consciousness / Q000187:drug effects*; D062787:Drug Overdose; D006801:Humans; D000077213:Lamotrigine; D012640:Seizures / Q000097:blood / Q000139:chemically induced*; D014227:Triazines / Q000097:blood / Q000506:poisoning*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine