Comedogenicity in rabbit: some cosmetic ingredients/vehicles.
The rabbit external ear canal was used to define which chemicals caused comedone formation on topical application. Some of the tested ingredients are currently used in topically applied formulations. Certain raw materials have been shown to produce follicular hyperkeratosis in the rabbit ear assay. This study quantifies comedogenic potential of cosmetic materials, including: isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristle myristate, cocoa butter, cetyl alcohol, paraffin, stearyl alcohol sodium lauryl sulfate (SLS), and petrolatum. The first nine were deemed positive. Factors aiding clinical relevance are listed.
Dermatology Department, University of California at San Francisco Medical School, San Francisco, California 94143-0989, USA.
Shawn H
SH
Nguyen
Thao P
TP
Dang
Howard I
HI
Maibach
D000152:Acne Vulgaris / Q000139:chemically induced*; D000818:Animals; D003358:Cosmetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011817:Rabbits; D012882:Skin Tests
D003358:Cosmetics