Novel keto-enamine Schiffs bases from 7-hydroxy-4-methyl-2-oxo-2H-benzo[h] chromene-8,10-dicarbaldehyde as potential antidyslipidemic and antioxidant agents.
A series of Schiff bases have been synthesized from dicarbaldehyde of benzocoumarin, in which the reactions were regioselective and the products existed in the keto-enamine form, in which the aromaticity of the relevant ring was disrupted. The compounds were evaluated in vitro for their antioxidant and in vivo for their antidyslipidemic activity for the first time. Compounds 3 and 7 possess significant lipid lowering and antioxidant activity.
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, Uttar pradesh 226 001, India. sashidhar123@gmail.com
Koneni V
KV
Sashidhara
Jammikuntla N
JN
Rosaiah
Gitika
G
Bhatia
J K
JK
Saxena
D000588:Amines / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005609:Free Radicals; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats; D012545:Schiff Bases / Q000737:chemistry
D000588:Amines; D000975:Antioxidants; D003374:Coumarins; D005609:Free Radicals; D000960:Hypolipidemic Agents; D012545:Schiff Bases