Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.
Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase.
Min
Hye-Young
HY
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Park
Eun-Jung
EJ
Hong
Ji-Young
JY
Kang
You-Jin
YJ
Kim
Sun-Jack
SJ
Chung
Hwa-Jin
HJ
Woo
Eun-Rhan
ER
Hung
Tran Manh
TM
Youn
Ui Jung
UJ
Kim
Yeong Shik
YS
Kang
Sam Sik
SS
Bae
KiHwan
K
Lee
Sang Kook
SK
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*
D034242:Cyclooctanes; D017705:Lignans; C510994:dibenzocyclooctadiene lignan