The importance of risk factor reduction in erectile dysfunction.
Erectile dysfunction (ED) is associated with modifiable risk factors. Obesity, physical inactivity, and the metabolic syndrome increase the incidence of ED and markers of low-grade inflammation, which in turn are associated with endothelial dysfunction. Intensive intervention with lifestyle advice focusing on a healthy diet, weight loss, and increased physical activity benefits men with ED, reducing the markers of inflammation and improving endothelial function. Though phosphodiesterase type 5 inhibitors are highly effective in treating ED, lifestyle advice and aggressive risk reduction remain fundamental to the overall vascular good health of the individual.
Cardiothoracic Centre, 6th floor, East Wing, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom. gjcardiol@talk21.com
Graham
G
Jackson
D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D011322:Primary Prevention / Q000379:methods; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology