Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis.
Three new Securinega alkaloids, secu'amamines B-D ( 1- 3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues ( 4, 6- 9). The structures 1- 3 were elucidated by spectroscopic methods including 2D NMR, and all eight compounds were evaluated for cytotoxicity against two cancer cell lines.
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan. a-ohsaki.fm@tmd.ac.jp
Ayumi
A
Ohsaki
Yukino
Y
Kobayashi
Kaisuke
K
Yoneda
Akio
A
Kishida
Haruaki
H
Ishiyama
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006572:Heterocyclic Compounds, Bridged-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D051379:Mice; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006572:Heterocyclic Compounds, Bridged-Ring; C527014:secu'amamine B; C527015:secu'amamine C; C527016:secu'amamine D