Effects of the serotonin and noradrenaline reuptake inhibitor (SNRI) milnacipran on marble burying behavior in mice.
The effects of milnacipran, a serotonin and noradrenaline reuptake inhibitor (SNRI) on the obsessive compulsive disorder (OCD) model, marble burying behavior, were investigated in mice. Milnacipran above the dosage of 10 mg/kg inhibited marble burying behavior significantly in mice as similar to fluvoxamine. Milnacipran inhibiting marble burying behavior did not affect locomotor activity. These results suggest that milnacipran can inhibit marble burying behavior and that milacipran may be useful for OCD therapy.
Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Matano-cho, Totsukaku, Yokohama 245-0066, Japan. yumisugi@hamayaku.ac.jp
Yumi
Y
Sugimoto
Noriko
N
Tagawa
Yoshiharu
Y
Kobayashi
Yoshihiro
Y
Hotta
Jun
J
Yamada
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003521:Cyclopropanes / Q000494:pharmacology*; D016666:Fluvoxamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000078764:Milnacipran; D009043:Motor Activity / Q000187:drug effects; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D018759:Adrenergic Uptake Inhibitors; D003521:Cyclopropanes; D016666:Fluvoxamine; D000078764:Milnacipran; D017367:Selective Serotonin Reuptake Inhibitors