Scope of a novel three-component synthesis of highly functionalized pyridines(dagger).
A mechanistically unique three-component synthesis provides a variety of functionalized pyridine derivatives in fair to excellent yields. The scope of this reaction was studied with respect to the alkoxyallene, the nitrile, and the carboxylic acid. Due to the 4-hydroxy group, these pyridine derivatives are suitable precursors for subsequent palladium-catalyzed reactions. Suzuki couplings of the corresponding pyridyl nonaflates lead to a variety of pyridine and bipyridine derivatives.
Dash
Jyotirmayee
J
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, D-14195 Berlin, Germany.
Lechel
Tilman
T
Reissig
Hans-Ulrich
HU
D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis*
D011725:Pyridines; D010165:Palladium