Nuclear factor-kappaB, an unappreciated tumor suppressor.
The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers.
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. fchen@cdc.gov
Fei
F
Chen
Vince
V
Castranova
D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy*
D016328:NF-kappa B