Genomics and biology of the nematode Caenorhabditis briggsae.
The soil nematode Caenorhabditis briggsae is an attractive model system for studying evolution of both animal development and behavior. Being a close relative of C. elegans, C. briggsae is frequently used in comparative studies to infer species-specific function of the orthologous genes and also for studying the dynamics of chromosome evolution. The genome sequence of C. briggsae is valuable in reverse genetics and genome-wide comparative studies. This review discusses resources and tools, which are currently available, to facilitate study of C. briggsae in order to unravel mechanisms of gene function that confer morphological and behavioral diversity.
Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada. guptab@mcmaster.ca
Bhagwati P
BP
Gupta
Robert
R
Johnsen
Nansheng
N
Chen
D000818:Animals; D005075:Biological Evolution; D002107:Caenorhabditis / Q000235:genetics* / Q000502:physiology; D049751:Genome, Helminth; D006801:Humans