NAD+ and NADH in neuronal death.
Neuronal death is a key pathological event in multiple neurological diseases. Increasing evidence has suggested that NAD+ and NADH mediate not only energy metabolism and mitochondrial functions, but also calcium homeostasis, aging, and cell death. This article is written to provide an overview about the information suggesting significant roles of NAD+ and NADH in neuronal death in certain neurological diseases. Our latest studies have suggested that intranasal administration with NAD+ can profoundly decrease ischemic brain damage. These observations suggest that NAD+ administration may be a novel therapeutic strategy for some neurological diseases.
Department of Neurology (127), University of California at San Francisco and San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. Weihai.Ying@ucsf.edu
Weihai
W
Ying
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009243:NAD / Q000502:physiology* / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*
D009243:NAD