A universal combination treatment for vaginitis.
BACKGROUND
We compared a novel vaginal tablet consisting of 100 mg of clotrimazole and 100 mg of metronidazole ('Clo-Met') to a 100-mg clotrimazole tablet in the treatment of vaginitis.


METHODS
A multicenter, double-blind, randomized controlled study. Women with vaginal discharge and diagnosed as suffering from vaginitis caused by Trichomonas vaginalis, bacterial vaginosis or Candida albicans, or any combination of the three, and who had not received treatment for vaginitis during the previous month, were studied.


RESULTS
165 patients were enrolled into the study--84 into the combined therapy group, and 81 into the clotrimazole group. In women with Candida vaginitis, Clo-Met was more effective than clotrimazole treatment (p < 0.012 and p < 0.05, respectively).


CONCLUSIONS
A combination vaginal tablet consisting of clotrimazole and metronidazole is therapeutically effective in candidal vaginitis. The effectiveness of Clo-Met on bacterial vaginosis, T. vaginalis infection as well as on vaginal infections due to a combination of these microorganisms should be studied further.
Department of Obstetrics and Gynecology, Western Galilee Hospital, Nahariya, Israel. mdjacob@gmail.com
Jacob
J
Bornstein
Doron
D
Zarfati
D000282:Administration, Intravaginal; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D003022:Clotrimazole / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D014627:Vaginitis / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D004338:Drug Combinations; D008795:Metronidazole; D003022:Clotrimazole