Improving cardiovascular risk stratification: the case for redefining microalbuminuria.
Large epidemiological studies have pointed out that regardless of the degree of hypertension, the cost-effectiveness of antihypertensive treatment increases in parallel with the global burden of risk. Therefore, there has been growing interest in developing sensitive and easy-to-perform ways to accurately and inexpensively identify patients at high cardiovascular risk. Numerous studies over the past years have provided evidence that microalbuminuria is a concomitant of extrarenal signs of hypertensive organ damage, as well as a strong, independent predictor of cardiovascular and cerebrovascular events. Recent clinical data indicate that the risk of cardiovascular morbidity and mortality is linearly related to the degree of urinary albumin excretion, with no identifiable threshold or plateau. Furthermore, it has been demonstrated that a reduction in albuminuria under antihypertensive treatment is paralleled by changes in cardiovascular risk. Therefore, the routine search for microalbuminuria could lead to a significant improvement in the evaluation and treatment of patients with primary hypertension.
Department of Internal Medicine and Cardionephrology, Azienda Universitaria Ospedale San Martino, University of Genoa, Genoa - Italy.
Giovanna
G
Leoncini
Elena
E
Ratto
Francesca
F
Viazzi
Angelica
A
Parodi
Valeria
V
Falqui
Novella
N
Conti
Cinzia
C
Tomolillo
Giacomo
G
Deferrari
Roberto
R
Pontremoli
D000419:Albuminuria / Q000175:diagnosis* / Q000209:etiology; D000959:Antihypertensive Agents / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000401:mortality*; D008297:Male; D018570:Risk Assessment; D016896:Treatment Outcome
D000959:Antihypertensive Agents