Synthesis and characterization of radiopaque iodine-containing degradable PVA hydrogels.
Poly (vinyl alcohol) (PVA) hydrogels are highly attractive for biomedical applications, especially for controlled release of drugs and proteins. Recently, degradable PVA hydrogels have been described, having the advantage that the material disappears over time from the implantation site. Herein, we report the synthesis of radiopaque degradable PVA, which gives a further advantage that the position of the hydrogel can precisely be determined by X-ray fluoroscopy. Radiopacity has been introduced by replacing 0.5% of the pendent alcohol groups on the PVA with 4-iodobenzoylchloride. This level of substitution rendered the polymer adequately radiopaque. The subsequent modification of 0.8% of the pendent hydroxyl groups with an ester acrylate functional group allowed for cross-linking of the macromers. The radiopaque hydrogels degraded over a time span of 140 days. Rheology data suggested that the macromer solutions were appropriate for injection.
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
Damia
D
Mawad
Laura A
LA
Poole-Warren
Penny
P
Martens
Leo H
LH
Koole
Tristan L B
TL
Slots
Catharina S J
CS
van Hooy-Corstjens
D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*
D020100:Hydrogels; D007457:Iodine Radioisotopes; D011142:Polyvinyl Alcohol