[The effect of low-dose rate radiation simulating the high-altitude flight conditions on mice in vivo].
In present work, we investigated the peculiarities of the effect of a low-dose rate high-LET radiation that simulates the spectral and component composition of the radiation field formed in the atmosphere at a height of 10 km on mice in vivo. The dose dependence and adaptive response were examined. Irradiation of mice was performed for 24 h a day in the radiation field behind the concrete shield of the Serpukhov accelerator of 70 GeV protons for the time (15-31 days) necessary to accumulate the required doses. The experiments demonstrated that irradiation of mice in vivo in the dose range of 11.5-31.5 cGy leads to an increase in cytogenetic damage to bone marrow cells and induces no adaptive response in bone marrow cells.
Zaichkina
S I
SI
Rozanova
O M
OM
Akhmadieva
A Kh
AKh
Aptikaeva
G F
GF
Smirnova
E N
EN
Romanchenko
S P
SP
Vakhrusheva
O A
OA
Sorokina
S S
SS
Peleshko
V N
VN
D000222:Adaptation, Physiological; D000818:Animals; D001359:Aviation; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008954:Models, Biological; D014916:Whole-Body Irradiation