[Role of "oxidant-antioxidant" system and genetic biochemical polymorphism in pathogenesis of occupational allergic dermatosis].
Studying "oxidant-antioxidant" system in patients with occupational allergic dermatosis revealed hyperactivity of free radical oxidation and depressed antioxidant system, especially its nonenzymatic unit. Finding also is high share of antibodies to double-stranded DNA in patients with occupational allergic dermatosis. Zero genotype of GSTM1 system is characterized by early (up to 5 years) development,severe course and unfavorable prognosis of occupational skin diseases.
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Lazarashvili
D000328:Adult; D000906:Antibodies / Q000276:immunology; D000975:Antioxidants / Q000502:physiology*; D004247:DNA / Q000235:genetics / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000235:genetics* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D000906:Antibodies; D000975:Antioxidants; D004247:DNA; D005982:Glutathione Transferase