Dilation of renal artery stenosis after administration of losartan.
Transluminal angioplasty with a balloon catheter is effective to dilate renal artery stenosis (RAS) caused by fibromuscular dysplasia (FMD), but lesions resistant to the angioplasty exist. In this report, we describe the case of a young woman with RAS of FMD that was difficult to dilate even by cutting-balloon angioplasty. To facilitate the formation of a smooth intimal covering at the site of angioplasty, we administered losartan, an angiotensin receptor blocker, for 4 months after the angioplasty. Although re-stenosis was detected at 5 months after the angioplasty, the normotensive state continued without antihypertensives and the re-stenosis gradually dilated afterwards. The present case suggests the possibility of remodeling the renal artery during the normotensive state by administering losartan after the angioplasty.
Tanemoto
Masayuki
M
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. mtanemoto-tky@umin.ac.jp
Takase
Kei
K
Yamada
Takayuki
T
Satoh
Akihiro
A
Abe
Takaaki
T
Ito
Sadayoshi
S
D000328:Adult; D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D005352:Fibromuscular Dysplasia / Q000150:complications*; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications* / Q000209:etiology; D019808:Losartan / Q000627:therapeutic use*; D012078:Renal Artery Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D017211:Treatment Failure
D000959:Antihypertensive Agents; D019808:Losartan