Blurring the boundary: the nuclear envelope extends its reach.
The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.
Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore.
Colin L
CL
Stewart
Kyle J
KJ
Roux
Brian
B
Burke
D000818:Animals; D003593:Cytoplasm / Q000502:physiology / Q000648:ultrastructure; D003599:Cytoskeleton / Q000469:parasitology / Q000502:physiology / Q000648:ultrastructure; D030342:Genetic Diseases, Inborn / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D034882:Lamins / Q000235:genetics; D008938:Mitosis; D009154:Mutation; D009685:Nuclear Envelope / Q000502:physiology* / Q000648:ultrastructure*; D034881:Nuclear Lamina / Q000502:physiology / Q000648:ultrastructure; D022022:Nuclear Pore / Q000502:physiology / Q000648:ultrastructure; D015398:Signal Transduction; D014777:Virus Diseases / Q000378:metabolism / Q000821:virology
D034882:Lamins