Nucleolipids as potential organogelators.
Four different series of nucleolipids or bola-nucleolipids were synthesized or re-synthesized. Most of the compounds were studied with respect to their gelation properties toward either water or aromatic, hetero-aromatic, and aliphatic hydrocarbons. Bola-nucleolipids 6 and 7 do not gelate any solvent tested, neither as sole additive nor by adding up to 10 wt% of a 1:1 mixture. The nucleolipid 22 carrying the antiviral acyclovir as a head group proved to be a potent organogelator for aromatic hydrocarbons such as toluene, but not for hetarenes, aliphatic hydrocarbons or water. The mono-tailed nucleolipid 24 exhibits excellent organogelator properties for both aromatic and aliphatic hydrocarbons. These were studied as a function of concentration and temperature.
Organische Chemie I - Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Osnabrück, Germany. Helmut.Rosemeyer@uos.de
Helmut
H
Rosemeyer
Eva-Maria
EM
Stürenberg
Piet
P
Herdewijn
D000212:Acyclovir / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D005782:Gels; D006838:Hydrocarbons; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents; D014867:Water
D005782:Gels; D006838:Hydrocarbons; D008055:Lipids; D009705:Nucleosides; D012997:Solvents; D014867:Water; D000212:Acyclovir