How common is fatigue in disease-free breast cancer survivors? A systematic review of the literature.
BACKGROUND
There is some debate in the literature as to whether fatigue persists in the long term in women who have completed adjuvant breast cancer treatment.


METHODS
A systematic review was conducted in order to characterise and quantify the phenomenon of post treatment fatigue (PTF).


RESULTS
There was a wide variation in the measures of fatigue used, duration of follow-up and type of comparison made. Overall 18 studies were identified with a follow-up period of between 4 months and 10 years. Fourteen studies demonstrated the presence of continued PTF and/or differences in fatigue levels compared to a reference population up to 5 years after treatment. One short-term study reported no increase in fatigue at 4 months. Three studies (with an average follow up period of longer than 5 years) did not identify overall quality of life differences in breast cancer survivors when compared with a reference population. However there were significant differences in measures of physical functioning and mental fatigue.


CONCLUSIONS
The authors conclude that there is good evidence of PTF occurring up to 5 years after completion of adjuvant therapy.
Minton
O
O
Macmillan reader in palliative medicine, Division of mental health, St. Georges University of London, 6th floor Hunter Wing, Cranmer Terrace, London, SW17 ORE, UK. ominton@sgul.ac.uk
Stone
P
P
D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D005221:Fatigue / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015996:Survival Rate; D017741:Survivors