[Pineapple juice as a negative oral contrast agent in magnetic resonance cholangiopancreatography].
OBJECTIVE
The quality of magnetic resonance cholangiopancreatography (MRCP) images is frequently degraded by high signal from the gastrointestinal tract on heavily T2W images. The purpose of this study is to evaluate pineapple juice (PJ) as an oral negative contrast agent in MRCP.


METHODS
Results from MRCP in 50 patients with PJ and 50 patients with paramagnetic contrast (ferumoxsil-Lumirem) were compared. Reviewers were blinded to the type of contrast agent. Exam quality was recorded with regards to signal suppression in the stomach, duodenum and proximal small bowel and with regards to pancreatic duct and biliary ducts visualization. In vitro, the signal characteristics of several commercially available brands of PJ were assessed using T1W, T2W and MRCP sequences. Signal intensity was correlated with the manganese concentration measured using atomic absorption spectrometry. Finally, the reviewers compared the taste of PJ and ferumoxsil.


RESULTS
On MRCP sequences, results were similar with regards to signal suppression in the stomach, duodenum and proximal small bowel with PJ and ferumoxsil. Visualization of the pancreatic duct, intrahgepatic bile ducts and CBD was similar with PJ and ferumoxsil. The signal intensity of commercially available brands of PJ on T2W and MRCP sequences correlated well with the measured manganese concentration on spectroscopy. Variations in manganese concentration were observed, with values ranging from 3.65 to 27.24 mg/L. The reviewers noted that PJ tasted "good" or "very good" and that ferumoxsil tasted "bad" or "very bad".


CONCLUSIONS
Ingestion of PJ provides effective signal suppression in the GI tract on MRCP, similar to paramagnetic contrast agents. Because manganese concentration is highly variable in commercially available PJ brands, a brand with high manganese concentration should be selected.
Arrivé
L
L
Service de radiologie, Assistance-Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris. lionel.arrive@sat.ap-hop-paris.fr
Coudray
C
C
Azizi
L
L
Lewin
M
M
Hoeffel
C
C
Monnier-Cholley
L
L
Lacombe
C
C
Vautier
S
S
Poupon
J
J
Tubiana
J M
JM
D000284:Administration, Oral; D031230:Ananas; D001628:Beverages; D016009:Chi-Square Distribution; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D052203:Ferrosoferric Oxide; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007501:Iron; D058185:Magnetite Nanoparticles; D008345:Manganese / Q000032:analysis; D010087:Oxides; D012833:Siloxanes; D013054:Spectrophotometry, Atomic; D013649:Taste
D003287:Contrast Media; D058185:Magnetite Nanoparticles; D010087:Oxides; D012833:Siloxanes; D008345:Manganese; C088769:ferumoxsil; D007501:Iron; D052203:Ferrosoferric Oxide