Non-covalent interactions of a drug molecule encapsulated in a hybrid silica gel.
The drug molecule Propranolol has been encapsulated by a sol-gel process in an organic-inorganic hybrid matrix by in-situ self-assembly; the 2D HETCOR solid state NMR spectroscopy provides direct proof of the intimate spatial relationship between the host matrix and guest drug molecules.
Paul
Geo
G
Institut für Physikalische Chemie and Graduate School of Chemistry, Westfälische Wilhelms-Universität, Corrensstrasse 36, Münster, Germany.
Steuernagel
Stefan
S
Koller
Hubert
H
D002214:Capsules / Q000737:chemistry; D005782:Gels; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D011433:Propranolol / Q000737:chemistry*; D012015:Reference Standards; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors
D002214:Capsules; D005782:Gels; D012822:Silicon Dioxide; D011433:Propranolol