Hsp90 canalizes developmental perturbation.
Stochastic processes are intrinsic phenomena that perturb developmental processes. However, the canalization process restricts the magnitude of perturbation and hence the magnitude of morphological variation during development. Heat-shock protein 90 (Hsp90) chaperones are a class of proteins stabilizing a network of 'client' proteins that are involved in diverse signal transduction pathways affecting development. Here it is reported that a reduction of Hsp90 gene dose creates canalization perturbations that affect many aspects of Arabidopsis development and results in a plethora of morphological alterations. Hence, Hsp90 restricts stochastic phenomena by minimizing perturbations, thereby canalizing development. It is also shown that morphogenesis is determined by three mutually inter-related parameters: genotype, environment, and time. Hsp90 is involved in the interaction of these three parameters which ultimately affect developmental processes. The amount of phenotypic variation upon the reduction of Hsp90 function could be perceived as adaptive and could have an impact on the evolutionary process.
Samakovli
Despina
D
Laboratory of Molecular Biology, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece.
Thanou
Aggeliki
A
Valmas
Charalampos
C
Hatzopoulos
Polydefkis
P
D017360:Arabidopsis / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006358:Hot Temperature; D009154:Mutation; D050794:STAT1 Transcription Factor; D013269:Stochastic Processes
D018841:HSP90 Heat-Shock Proteins; D050794:STAT1 Transcription Factor