An efficient synthesis of chiral beta-hydroxy sulfones via ru-catalyzed enantioselective hydrogenation in the presence of iodine.
Ru-SUNPHOS catalyzed asymmetric hydrogenation of a variety of sulfonyl ketones (R = alkyl, aryl) in the presence of iodine gave enantioenriched hydroxyl sulfones with good catalytic efficiency. Further investigation revealed that the in situ generated anhydrous HI is the operating additive.
School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China.
Xiaobing
X
Wan
Qinghua
Q
Meng
Hongwei
H
Zhang
Yanhui
Y
Sun
Weizheng
W
Fan
Zhaoguo
Z
Zhang
D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis*
D013450:Sulfones; D006859:Hydrogen; D007455:Iodine