[Immunopathology of Lyme arthritis].
Lyme borreliosis (Lyme disease) is the most prevalent tick-borne disease caused by spirochaetes of the Borrelia species complex. Arthritis is one of the common manifestations of B. burgdorferi infection. The pathomechanism of articular changes in Lyme arthritis has not yet been elucidated. Histopathological studies of synovia and immunological changes are similar to rheumatoid arthritis. In the early stage of inflammation B. burgdorferi interact with polynuclear granulocytes and epithelial cells, triggering production of reactive oxygen species, lipid peroxidation products and other inflammatory mediators. The imbalance between anabolic and catabolic processes in inflamed joints results in the progressive destruction of articular cartilage and disintegration of extracellular matrix. Molecular mimicry between OspA (outer surface protein A) and adhesion molecule LFA-1alpha seems to be responsible for chronic arthritis.
Akademia Medyczna w Białymstoku, Klinika Chorób Zakaźnych i Neuroinfekcji. neuroin@amb.edu.pl
Sławomir A
SA
Pancewicz
Ryszard
R
Rutkowski
Krzysztof
K
Rutkowski
Joanna M
JM
Zajkowska
Maciej
M
Kondrusik
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D001170:Arthritis, Infectious / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D025065:Borrelia burgdorferi / Q000276:immunology*; D002356:Cartilage / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008074:Lipoproteins / Q000276:immunology; D008193:Lyme Disease / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D051379:Mice; D018716:Molecular Mimicry / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D016207:Cytokines; D008074:Lipoproteins; D016169:Lymphocyte Function-Associated Antigen-1; C072045:OspA protein; D017382:Reactive Oxygen Species