Design, synthesis and biological evaluation of antipicornaviral pyrrole-containing peptidomimetics.
A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the alpha-nitrogen atom of the N-terminal amino acid incorporated into the pyrrole cycle. The synthesized compounds were tested for antiviral activity by agar-diffusion plaque inhibition test against Coxsackievirus B1 replication in FL cell. Four of the products were observed to possess an antiviral activity, which was proven to be significant for one product. N-terminal pyrrole moiety and C-terminal free carboxyl function are available in all active compounds. On the other hand, their corresponding -OBzl and -Obu t esters are inactive.
Minchev
I
I
University of Chemical Technology and Metallurgy, Department of Organic Chemistry, Sofia 1756, Bulgaria. ivaylo_min@yahoo.com
Vladimirova
S
S
Vezenkova
L
L
Bijeva
A
A
Moussis
V
V
Nikolaeva-Glomb
L
L
Tsikaris
V
V
Czeuz
M
M
Galabov
A
A
D000362:Agar; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015195:Drug Design; D029822:Enterovirus B, Human / Q000187:drug effects / Q000254:growth & development; D005973:Glutamine / Q000737:chemistry; D006801:Humans; D007930:Leucine / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry; D010849:Picornaviridae / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D010455:Peptides; D005973:Glutamine; D010649:Phenylalanine; D000362:Agar; D007930:Leucine