Scanning laser polarimetry demonstration of retinal nerve fiber layer damage in human immunodeficiency virus-positive patients without infectious retinitis.
BACKGROUND
To use scanning laser polarimetry with variable corneal compensation to measure the retinal nerve fiber layer (RNFL) in human immunodeficiency virus (HIV)-infected patients.


METHODS
Three groups were analyzed in a prospective cohort study from one center. Group A consisted of 52 eyes of HIV-positive patients whose CD4 cell counts had never fallen below 100/mm (1.0 x 10/L). Group B included 60 eyes of HIV-positive patients with CD4 cell counts that had fallen below 100/mm for at least 6 months in their history. Group C consisted of 50 eyes of HIV-negative patients. None of the eyes had a history of infectious retinitis. Retinal birefringence imaging studies were performed using a commercially available scanning laser. Superior, inferior, and ellipse averages as well as nerve fiber indicator parameters were used for comparison.


RESULTS
Group B significantly differed from group C in all parameters. Group B also differed from group A in all parameters with the exception of superior average. No difference was detected between group A and group C.


CONCLUSIONS
Scanning laser polarimetry demonstrated RNFL thinning in HIV-positive patients without retinitis who had a history of low CD4 cell counts compared with HIV-positive subjects with high CD4 cell counts and HIV-negative patients.
Kozak
Igor
I
Jacobs Retina Center, University of California at San Diego, USA.
Bartsch
Dirk-Uwe G
DU
Cheng
Lingyun
L
McCutchan
Allen
A
Weinreb
Robert N
RN
Freeman
William R
WR
D000328:Adult; D001718:Birefringence; D018791:CD4 Lymphocyte Count; D003315:Cornea / Q000502:physiology; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis*; D006801:Humans; D007834:Lasers; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*