Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals.
Growing evidence has demonstrated that chemokines released from epidermal cells control inflammatory skin diseases. Keratinocytes elaborate both Th1- and Th2-associated chemokines, although the former is more abundantly produced than the latter. Downmodulation of keratinocyte production of chemokines is one of the therapeutic approaches for cutaneous inflammatory disorders. Recent observations have shown that keratinocyte chemokine production can be modulated by well-used drugs, including antihistamines, antibiotics and antifungals. Utilization of the beneficial side effects of these drugs may by clinically valuable.
Tokura
Yoshiki
Y
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan. tokura@med.uoeh-u.ac.jp
Kobayashi
Miwa
M
Kabashima
Kenji
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D018925:Chemokines / Q000187:drug effects / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects* / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D012871:Skin Diseases / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018925:Chemokines; D006634:Histamine H1 Antagonists