Comprehensive assessment of P21 polymorphisms and lung cancer risk.
The purpose of this study is to comprehensively evaluate potential functional polymorphisms in the P21 gene in relation to the risk of lung cancer. We first determined the frequencies of P21 polymorphisms in 27 healthy Koreans, and then examined three polymorphisms (-2266G > A, S31R, and IVS2 + 16G > C), based on their frequencies and haplotype-tagging status, in a case-control study. Individuals with at least one -2266A allele were at a significantly decreased risk of lung cancer compared with those harboring the -2266 GG genotype [adjusted odds ratio (OR) = 0.71, 95% confidence interval (CI) = 0.53-0.95, P = 0.02). The haplotypes (ht2-4) carrying 31R or IVS2 + 16C alleles were associated with a significantly decreased risk of lung cancer compared with the haplotype 31S/IVS2 + 16G, which carried wild-type alleles at both loci (adjusted OR = 0.65, 95% CI = 0.50-0.83, P = 0.007)]. When the -2266A allele and ht2-4 were considered to be protective alleles, the risk of lung cancer decreased in a dose-dependent manner as the number of protective alleles increased (P = 0.0002). These results suggest that a combined analysis of these three P21 polymorphisms might better predict the risk of lung cancer than the analysis of a single polymorphism.
Choi
Yi Young
YY
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kang
Hyo-Kyung
HK
Cancer Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea.
Choi
Jin Eun
JE
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jang
Jin Sung
JS
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kim
Eun Jin
EJ
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Cha
Sung Ick
SI
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Lee
Won Kee
WK
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kam
Sin
S
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kim
Chang Ho
CH
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Han
Sung Beom
SB
Department of Internal Medicine, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Jung
Tae Hoon
TH
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Park
Jae Yong
JY
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. jaeyong@kyungpook.ac.kr.|Cancer Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea. jaeyong@kyungpook.ac.kr.|Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea. jaeyong@kyungpook.ac.kr.
D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21