Quantification of blood flow from rotational angiography.
For assessment of cerebrovascular diseases, it is beneficial to obtain three-dimensional (3D) information on vessel morphology and hemodynamics. Rotational angiography is routinely used to determine the 3D geometry and we propose a method to exploit the same acquisition to determine the blood flow waveform and the mean volumetric flow rate. The method uses a model of contrast agent dispersion to determine the flow parameters from the spatial and temporal development of the contrast agent concentration, represented by a flow map. Furthermore, it also overcomes artifacts due to the rotation of the c-arm using a newly introduced reliability map. The method was validated on images from a computer simulation and from a phantom experiment. With a mean error of 11.0% for the mean volumetric flow rate and 15.3% for the blood flow waveform from the phantom experiments, we conclude that the method has the potential to give quantitative estimates of blood flow parameters during cerebrovascular interventions.
Centre for Medical Image Computing, Department of Medical Physics & Bioengineering, University College London, UK. I.Waechter@cs.ucl.ac.uk
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I
Waechter
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Bredno
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Barratt
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J
Weese
D J
DJ
Hawkes
D000465:Algorithms; D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012399:Rotation; D012680:Sensitivity and Specificity