Use of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (P-15) in the treatment of class II furcation defects: a clinical and radiographic study in humans.
BACKGROUND
This study compared clinical and radiographic findings for the treatment of Class II furcation defects in human mandibular molars using anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) or open flap debridement (OFD).


METHODS
Twelve subjects showing two comparable Class II furcation defects in their mandibular molars were enrolled. The defects in each subject were assigned randomly to the test (ABM/P-15) or the control (OFD) group. Clinical measurements and standardized radiographs were taken at baseline and 6 to 7 months after surgery.


RESULTS
There were no statistically significant differences between the test and control groups for any clinical or radiographic parameter (P >0.05). On comparing the baseline and final measurements, the gain in horizontal clinical attachment level and reduction in gingival recession were significant only in the test group (P < or =0.02), whereas the gain in the vertical clinical attachment level was significant in both groups (P < or =0.04). In the test group, four of 12 sites showed complete closure, and five showed partial closure; in the control group, three defects showed complete closure, and four showed partial closure (P = 0.42). Subtraction radiography revealed similar gains in bone height and increases in mean bone density with both treatments (P >0.05).


CONCLUSIONS
ABM/P-15 yielded favorable results in the treatment of Class II furcation defects over a 6-month evaluation period; however, there was no difference compared to OFD. Further studies using a larger sample size are needed to confirm the present findings.
Department of Periodontics, São Leopoldo Mandic Dental Research Center, Campinas, SP, Brazil.
Ana L
AL
Eto
Julio C
JC
Joly
Marjorie
M
Jeffcoat
Ney S
NS
de Araújo
Vera C
VC
de Araújo
Patricia R
PR
Cury
D000328:Adult; D000818:Animals; D001861:Bone Regeneration; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D004311:Double-Blind Method; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D017823:Furcation Defects / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D010518:Periodontitis / Q000150:complications; D016300:Radiography, Bitewing; D018709:Statistics, Nonparametric; D013382:Subtraction Technique; D013524:Surgical Flaps; D016896:Treatment Outcome
D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen; D017886:Durapatite