Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21).
Association of a t(9;22)(q34;q11), BCR/ABL-positive, with a dic(19;21)(p13;p13) has been described in acute lymphoblastic leukemia in relapse, raising the question of whether this association is recurrent. Described here are two cases, one of myeloproliferative disease and one of acute lymphoblastic leukemia, both presenting a masked t(9;22) and t(19;21). Chromosomal rearrangements were ascertained by fluorescence in situ hybridization (FISH) using locus-specific probes, multicolor FISH, and bacterial artificial chromosome array. These additional observations suggest a nonrandom association.
Struski
Stéphanie
S
Institute of Hematology, Faculty of Medicine, 4 rue Kirschleger, 67000 Strasbourg, France. Stephanie.struski@chru-strasbourg.fr
Hélias
Catherine
C
Gervais
Carine
C
Leymarie
Vincent
V
Audhuy
Bruno
B
Moskovtchenko
Philippe
P
Lutz
Patrick
P
Gaub
Marie-Pierre
MP
Lessard
Michel
M
D000293:Adolescent; D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl