Alcohol consumption, %CDT, GGT and blood pressure change during alcohol treatment.
OBJECTIVE
Blood pressure (BP) changes in alcohol-dependent individuals during a 12-week alcohol relapse prevention study were examined in light of drinking status and biomarkers of alcohol consumption [carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transpeptidase (GGT)].


METHODS
Of 160 randomized alcoholic individuals, 120 who had hypertension and in whom daily drinking data was available, at 6 and 12 weeks of treatment were included. The impact of alcohol consumption on change in systolic BP (SBP) and diastolic BP (DBP) was examined. Further analysis determined the relationship between BP and alcohol-use biomarkers.


RESULTS
A significant effect of complete abstinence on both SBP (-10 mmHg; P = 0.003) and DBP (-7 mmHg; P = 0.001) when compared to any drinking (SBP and DBP = -1 mmHg) was observed. At week 12, participants with a positive %CDT (> or =2.6) had 7 mmHg greater SBP (P = 0.01) and DBP (P < 0.001) than those with negative %CDT. Participants with positive GGT (> or =50 IU) had 10 mmHg greater SBP (P = 0.12) and 9 mmHg greater DBP (P = 0.03) than those with negative GGT. The percent change in SBP was correlated with percent change in %CDT (P = 0.003) but not GGT (P = ns). The percent change in DBP was correlated with both percent change in %CDT (P < 0.0001) and GGT (P = 0.03).


CONCLUSIONS
Abstinence from alcohol significantly decreased the BP and a positive relationship between BP and both alcohol-use biomarkers was illustrated. Since %CDT is more specific than GGT for heavy alcohol consumption, clinicians may monitor the role of alcohol in hypertension using %CDT as a supplemental aid, providing an objective assessment of drinking to influence BP treatment decisions.
Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA. baros@musc.edu
A M
AM
Baros
T M
TM
Wright
P K
PK
Latham
P M
PM
Miller
R F
RF
Anton
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D000437:Alcoholism / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016320:Substance Abuse Treatment Centers / Q000379:methods; D014168:Transferrin / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000032:analysis / Q000097:blood*
D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D005723:gamma-Glutamyltransferase