Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC.
Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.
Department of Pathology and Immunology, Washington University School of Medicine, St Louis MO 63110, USA.
Melissa K
MK
Swiecki
Marco
M
Colonna
D000818:Animals; D003713:Dendritic Cells / Q000378:metabolism*; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D037181:Lectins, C-Type / Q000276:immunology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017452:Receptors, IgG / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
C443299:CLEC4C protein, human; D007370:Interferon Type I; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D011505:Protein-Tyrosine Kinases; D013755:Tetradecanoylphorbol Acetate