Magnesium ions and ionic channels: activation, inhibition or block--a hypothesis.
The interactions between magnesium ions and ionic membrane channels are complicated and may be classified in three categories: activation, reduction and inhibition of the ionic fluxes across the channels, corresponding to three mechanisms: open-block-close. The interactions between magnesium ions and various ionic channels are reviewed and the explanations of the three mechanisms are analyzed in term of screening/binding effects on the membrane surface polar head groups.
Laboratory of Physiology and Physiopathology, University P.M. Curie-Paris VI, Paris, France
Andrée
A
Guiet-Bara
Jean
J
Durlach
Michel
M
Bara
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D017136:Ion Transport / Q000187:drug effects; D008274:Magnesium / Q000378:metabolism* / Q000494:pharmacology; D008954:Models, Biological
D007473:Ion Channels; D008274:Magnesium