Functional oncocytic adrenocortical carcinoma.
We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.
Ali
Abdullah Essa
AE
Department of Pathology, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Room E-432, Toronto, ON, M4N 3M5, Canada.
Raphael
Simon J
SJ
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology*; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D024862:Oxyphil Cells / Q000473:pathology
D000450:Aldosterone; D006854:Hydrocortisone