Formation of substituted pyrroles via an imine condensation/Aza-Claisen rearrangement/imine-allene cyclization process by MAOS.
A diverse collection of pyrroles has been prepared using a one-pot, domino aldehyde/amine condensation, [3,3]-aza-Claisen rearrangement, imine-allene cyclization strategy. This protocol was accelerated by microwave irradiation and provided very good levels of conversion after reacting for only 30 min.
Bremner
W Stacy
WS
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada. organ@yorku.ca
Organ
Michael G
MG
D000466:Alkadienes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D000466:Alkadienes; D001372:Aza Compounds; D007097:Imines; D011758:Pyrroles; C025947:propadiene