A panel of multiple markers associated with chronic systemic inflammation and the risk of atherogenesis is detectable in asthma and chronic obstructive pulmonary disease.
Asthma and chronic obstructive pulmonary disease (COPD) are both lung diseases involving chronic inflammation of the airway. The injury is reversible in asthma whereas it is mostly irreversible in COPD. Both patients of asthma and COPD are known at risk for cardiovascular disease (CVD) and type 2 diabetes (T2DM), nephropathy, and cancer. We measured multiple risk markers for atherogenesis in 55 patients with asthma and 62 patients with COPD. We wanted to know whether risk markers for atherogenesis corresponding to sequence of events of chronic inflammation were also detectable in the airway inflammatory diseases. Elevation of almost all markers involving inflammation of the endothelial cells in the coronary artery were detectable in asthma and COPD involving the inflammation of the epithelial cell lining of the airway. Both the level and % elevation of all markers were found mostly higher in COPD, the more severe form of the lung disease. We believe that these markers are useful for predicting risk of developing clinical complications such as CVD.
Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Tsu-Lan
TL
Wu
Pi-Yueh
PY
Chang
Kuo-Chien
KC
Tsao
Chien-Feng
CF
Sun
Lily L
LL
Wu
James T
JT
Wu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000652:urine; D001249:Asthma / Q000150:complications / Q000175:diagnosis*; D050197:Atherosclerosis / Q000209:etiology*; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis*; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000032:analysis
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein