The effect of Teucrium polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats.
Teucrium polium is an analgesic, antidiabetic and antilipeidemic herbal medicament. The aim of this survey was to evaluate the effect of aqueous extract T. polium on liver enzymes linked to liver dysfunction, serum lipids and glucose, in diabetic male rats.



A total of 20 Sprague-Dawly male rats became diabetic by intraperitoneal injection of streptozotocin (60 mg/kg). the animals were divided randomly into two groups. Experimental group was fed Teucrium polium (50 mg/kg) for a month but control group was received the same volume of distilled water. Liver enzymes, biochemical parameters (cholesterol, triglyceride, low density lipoprotein, alanine transaminase, aspartae transaminase) and glucose were measured by kinetic (Enzymatic) and colorimetric methods. Data obtained were analyzed and mean values were compared by paired student's t-test. The results were expressed as mean +/- SD. Significant differences were set at P < 0.05.



Our results showed that in test group, serum glucose values decreased significantly (P < 0.05), but cholesterol, triglyceride, low density lipoprotein, alanine transaminase and aspartae transaminase increased significantly after use of T. polium (P < 0.05). This parameters value did not show any changes in control group.



Although the aqueous extract of Teucrium polium has strong hypoglycemic properties in experimental animals, but because of some hepatotoxic effects, it is not suitable to use it in human as an antidiabetic agent.
Shahraki
Mohammad Reza
MR
Dept. of Physiology, Zahedn University of Medical Sciences, Faculty of Medicine, Zahedan, Iran.
Arab
Mohammad Reza
MR
Dept. of Histology, Zahedn University of Medical Sciences, Faculty of Medicine, Zahedan, Iran.
Mirimokaddam
Ebrahim
E
Dept. of Hematology, Zahedn University of Medical Sciences, Faculty of Medicine, Zahedan, Iran.
Palan
Mony Jey
MJ
Dept. of English Language, Zahedan University of Medical Sciences; Zahedan, Iran.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008517:Phytotherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D031367:Teucrium / Q000633:toxicity
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase