Ruthenium-catalyzed cycloaddition of aryl azides and alkynes.
The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Lars Kyhn
LK
Rasmussen
Brant C
BC
Boren
Valery V
VV
Fokin
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D012428:Ruthenium / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D012428:Ruthenium