Targeting RNA with cysteine-constrained peptides.
A combined approach for targeting RNA with novel, biologically active ligands has been developed using a cyclic peptide library and in silico modeling. This approach has successfully identified novel cyclic peptide constructs that can target bTAR RNA. Subsequently, RNA/peptide interactions were effectively modeled using the HADDOCK docking program.
Burns
Virginia A
VA
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Bobay
Benjamin G
BG
Basso
Anne
A
Cavanagh
John
J
Melander
Christian
C
D001483:Base Sequence; D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D010456:Peptides, Cyclic; D012313:RNA; D003545:Cysteine