Bicyclic guanidine-catalyzed enantioselective phospha-Michael reaction: synthesis of chiral beta-aminophosphine oxides and beta-aminophosphines.
Chiral bicyclic guanidine has been found to catalyze the phospha-Michael reactions of diaryl phosphine oxide to nitroalkenes with high enantioselectivities, offering a direct methodology to prepare chiral beta-aminophosphine oxides and beta-aminophosphines.
Department of Chemistry, 3 Science Drive 3, National University of Singapore, Singapore, 117543.
Xiao
X
Fu
Zhiyong
Z
Jiang
Choon-Hong
CH
Tan
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D019791:Guanidine / Q000737:chemistry*; D008958:Models, Molecular; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D011336:Probability; D013237:Stereoisomerism; D013696:Temperature
D019086:Bridged Bicyclo Compounds, Heterocyclic; D010087:Oxides; D010720:Phosphines; C044646:phosphine; D019791:Guanidine