[Direct nitrate reductase method of assessment of Mycobacterium tuberculosis susceptibility to drug].
Microbiological method of direct accelerated assessment of resistance of Mycobacterium tuberculosis to rifampicin and isoniazide was developed which is able to detect multidrug resistant M. tuberculosis 10-21 days after obtaining of sputum--4-5 times faster compared with the method of absolute concentrations. Efficacy of the method was 0.93 and 0.96 during assessment of susceptibility to rifampicin and isoniazide respectively.
Poliakov
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AE
Mazurova
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IK
D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D050901:Nitrate Reductase; D012293:Rifampin / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology; D013997:Time Factors; D014376:Tuberculosis / Q000382:microbiology*
D000904:Antibiotics, Antitubercular; D050901:Nitrate Reductase; D007538:Isoniazid; D012293:Rifampin