The challenge of recalcitrant acute otitis media: pathogens, resistance, and treatment strategy.
Recalcitrant acute otitis media (AOM), including 2 well-defined and sometimes related entities (persistent AOM and recurrent AOM), is a common pediatric problem. Episodes of AOM in children with either persistent or recurrent AOM were shown to be associated with recovery of middle ear fluid bacterial pathogens (particularly Streptococcus pneumoniae) with higher resistance to antibiotics compared with children with AOM not recently treated with antibiotics. The relationships between nasopharyngeal carriage of Streptococcus pneumoniae and persistence of middle ear fluid pathogens despite clinical improvement or cure and subsequent recurrence are discussed in depth. The findings emphasize the importance of bacteriologic eradication in the prevention of recurrent AOM episodes.
Department of Pediatrics, Pediatric Infectious Disease Unit, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. eugenel@bgumail.bgu.ac.il
Eugene
E
Leibovitz
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002353:Carrier State; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007557:Israel; D009305:Nasopharynx / Q000382:microbiology; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000188:drug therapy; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents