Mono- and Di-sesquiterpenoids from Chloranthus spicatus.
Three new dimeric sesquiterpenoids, chloramultilides B-D ( 1- 3), along with 10 known sesquiterpenoids, were isolated from the whole plant of Chloranthus spicatus. Their structures were established by physical data (1D and 2D NMR, MS). The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compound 1 exhibited moderate in vitro antifungal activity.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, PR China.
Yong-Jiang
YJ
Xu
Chun-Ping
CP
Tang
Chang-Qiang
CQ
Ke
Ji-Bao
JB
Zhang
Hans-Christoph
HC
Weiss
Ernst-Rudolf
ER
Gesing
Yang
Y
Ye
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C527009:chloramultilide B; C527010:chloramultilide C; C527011:chloramultilide D