Serotonin2C receptor mRNA editing in neuropathic pain model.
We investigated the effects on 5HT(serotonin) 2C receptor RNA editing efficiency of contusive SCI (spinal cord injury). Using cloning followed by sequence analysis on spinal cord samples taken, we compared mRNA editing. Our results might be evidence of a functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn.
Department of Anesthesiology & Intensive Care Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan. anakae@anes.med.osaka-u.ac.jp
Aya
A
Nakae
Kunihiro
K
Nakai
Tatsuya
T
Tanaka
Masaki
M
Takashina
Satoshi
S
Hagihira
Masahiko
M
Shibata
Koichi
K
Ueda
Takashi
T
Mashimo
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D009437:Neuralgia / Q000209:etiology*; D017393:RNA Editing / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000150:complications
D012333:RNA, Messenger; D044405:Receptor, Serotonin, 5-HT2C