Comparison of gated SPECT, echocardiography and cardiac magnetic resonance imaging for the assessment of left ventricular ejection fraction and volumes.
BACKGROUND
Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV) can be determined non-invasively by two-dimensional enchocardiography (ECHO), gated sinle photon emission computed tomography (GSPECT) and cardiac magnetic resonance imaging (CMRI). This study was designed to analyze the concordance between LVEF, EDV and ESV values derived from ECHO, GSPECT and CMRI.


METHODS
ECHO, GSPECT and CMRI were performed in a group of 21 patients with suspected coronary artery disease. LVEF, EDV and ESV values were calculated.


RESULTS
The mean LVEF measured with GSPECT, ECHO and CMRI were 55.9+/-17.8%, 55.7+/-16.4% and 56.4+/-15.7%, respectively. The mean EDV measured with GSPECT, ECHO and CMRI were 109.2+/-42.45 mL, 127.5+/-42.2 mL, 91.1+/-38.0 mL, respectively. The mean ESV measured with GSPECT, ECHO and CMRI were 54.2+/-41.2 mL, 59.9+/-37.6 mL and 41.8+/-26.9 mL, respectively. The results of linear regression analysis showed very good correlation between LVEF and ESV values derived from GSPECT, ECHO adn CMRI (r=0.91, r=0.92, r=0.97 for LVEF and r=0.86, r=0-91, r=0.91 for ESV, P<0.01). Good correlations were found between EDV values obtained from GSPECT, ECHO and CMRI (r=0.71, r=0.68, r=0.73, P<0.01). Agreement between these techniques in LVEF values was also good, but not in LV volumes, according to Bland-Altman plots.


CONCLUSIONS
This study showed good overall correlations between LVEF, EDV and ESV values derived from GSPECT, ECHO and CMRI. LVEF obtained from any of these three imaging modalities could be used interchangeably. However, care should be taken in comparing LV volumes.
Demir
Hakan
H
Department of Nuclear Medicine, Department of Cardiology, Department of Radiology, Kocaeli University School of Medicine, Kocaeli, Turkey. hakandemir99@yahoo.com
Tan
Yusuf Z
YZ
Kozdag
Guliz
G
Isgoren
Serkan
S
Anik
Yonca
Y
Ural
Dilek
D
Demirci
Ali
A
Berk
Fatma
F
D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D004452:Echocardiography / Q000379:methods*; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*