The Mx GTPase family of interferon-induced antiviral proteins.
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herderstrasse 11, D-79008 Freiburg, Germany. otto.haller@uniklinik-freiburg.de
Otto
O
Haller
Silke
S
Stertz
Georg
G
Kochs
D000818:Animals; D000998:Antiviral Agents / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D004285:Dogs; D020558:GTP Phosphohydrolases / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D064547:Myxovirus Resistance Proteins; D051381:Rats; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D007372:Interferons; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins