Explaining phenotype heterogeneity in patients with psoriasis.
Psoriasis is a heterogeneous disorder with many different phenotypes. Further, different forms may alter their morphology and course of disease in that, for instance, plaque-type psoriasis may become pustular and vice versa. With advancing insight in immunopathology phenotype switching can now be explained by directional changes from T cell-mediated pathology to an inflammatory neutrophilic pattern which is driven by innate signalling. Within this framework not a single 'antigen' but various causative agents play a key role.
Christophers
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Department of Dermatology, Schleswig-Holstein University Clinic, Kiel, Germany. echristophers@dermatology.uni-kiel.de
D017668:Age of Onset; D015331:Cohort Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000276:immunology; D011565:Psoriasis / Q000235:genetics*; D012720:Severity of Illness Index
D020381:Interleukin-17