Nitroxyl radicals: electrochemical redox behaviour and structure-activity relationships.
Comparative study of electrochemical redox behaviour of five different nitroxyl radicals leads to the direct correlation between one-electron redox potentials and group electronegativity of the beta-substituent on the ring. Beta-substituents with an electron-donating effect caused a negative shift in the one-electron oxidation and one-electron reduction potentials of the nitroxyl radicals. In a similar aspect, beta-substituents with an electron-withdrawing effect behaved oppositely.
Radiation Modifier Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.
Sushma
S
Manda
Ikuo
I
Nakanishi
Kei
K
Ohkubo
Haruko
H
Yakumaru
Ken-ichiro
K
Matsumoto
Toshihiko
T
Ozawa
Nobuo
N
Ikota
Shunichi
S
Fukuzumi
Kazunori
K
Anzai
D000975:Antioxidants / Q000737:chemistry*; D004563:Electrochemistry; D005609:Free Radicals / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D000975:Antioxidants; D005609:Free Radicals; D009589:Nitrogen Oxides; C039900:nitroxyl