Signaling in the immune response.
Many pathogens that can infect C. elegans have been described, including some that co-exist with the nematode in its natural environment. This chapter describes our current understanding of the different innate immune responses of C. elegans that follow infection. It focuses on the main signalling pathways that have been identified and highlights the inclusion of certain molecular cassettes in both immune and developmental functions.
Centre d'Immunologie de Marseille-Luminy, INSERM/CNRS/Université de la Méditerranée, 13288 Marseille cedex 9, France. ewbank@ciml.univ-mrs.fr
Jonathan J
JJ
Ewbank
D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology* / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D009479:Neuropeptides / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; C117509:Dbl-1 protein, C elegans; D009479:Neuropeptides; D051193:Toll-Like Receptors; D016212:Transforming Growth Factor beta; D048049:Extracellular Signal-Regulated MAP Kinases