Years of sunlight exposure and cataract: a case-control study in a Mediterranean population.
BACKGROUND
We aimed to investigate the relation between sunlight exposure and risk of cataract.


METHODS
We carried out a frequency-matched case-control study of 343 cases and 334 controls attending an ophthalmology outpatient clinic at a primary health-care center in a small town near Valencia, Spain. All cases were diagnosed as having a cataract in at least one eye based on the Lens Opacification Classification system (LOCS II). Controls had no opacities in either eye. All cases and controls were interviewed for information on outdoor exposure, "usual" diet, history of severe episodes of diarrhea illness, life-style factors and medical and socio-demographic variables. Blood antioxidant vitamin levels were also analyzed. We used logistic regression models to estimate sex and age-adjusted odds ratios (ORs) by quintiles of years of occupational outdoor exposure, adjusting for potential confounders such as smoking, alcohol consumption, serum antioxidants and education.


RESULTS
No association was found between years of outdoor exposure and risk of cataract. However, exploratory analyses suggested a positive association between years of outdoor exposure at younger ages and risk of nuclear cataract later in life.


CONCLUSIONS
Our study does not support an association with cataract and sunlight exposure over adult life.
Pastor-Valero
María
M
London School of Hygiene and Tropical Medicine, London, UK. mariapastor_es@yahoo.com
Fletcher
Astrid E
AE
de Stavola
Bianca L
BL
Chaqués-Alepúz
Vicente
V
D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002386:Cataract / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D004522:Educational Status; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D018570:Risk Assessment; D013472:Sunlight / Q000009:adverse effects*; D013997:Time Factors