Methylated cyclodextrins: an efficient protective agent in water for zerovalent ruthenium nanoparticles and a supramolecular shuttle in alkene and arene hydrogenation reactions.
Zerovalent ruthenium(0) nanoparticles in the size range of 2.5 nm were easily prepared by chemical reduction of ruthenium salt with an excess amount of sodium borohydride and were efficiently stabilized by methylated cyclodextrins. The optimization of the catalytic system has been carried out in terms of stability and catalytic activity, considering the hydrogenation of olefinic compounds under biphasic liquid-liquid conditions. Efficient and controlled chemoselectivities were obtained in the hydrogenation of arene derivatives by the relevant choice of cavity and methylation degree of the cyclodextrins. Finally, the hydrogenation of alpha- and beta-pinenes leads to the major formation of cis-pinanes, interesting synthons for fine chemistry, with high diastereoisomeric excesses.
Equipe Synthèse Organique et Systèmes Organisés, UMR CNRS 6226 Sciences Chimiques de Rennes, Ecole Nationale Supérieure de Chimie de Rennes, Avenue du Gal Leclerc, 35700 Rennes, France.
Audrey
A
Denicourt-Nowicki
Anne
A
Ponchel
Eric
E
Monflier
Alain
A
Roucoux
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003505:Cyclodextrins / Q000737:chemistry*; D006865:Hydrogenation; D047028:Macrocyclic Compounds / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008745:Methylation; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000475:Alkenes; D003505:Cyclodextrins; D047028:Macrocyclic Compounds; D014867:Water; D012428:Ruthenium