[Application of reverse vaccinology in Schistosoma vaccine development: advances and prospects].
Current advances in reverse vaccinology based on the principle of "sequence-structure-function" and such integrated platform technologies as immunoinformatics, computer-aid design, and various high-throughput omics (including genomics, transcriptomics and proteomics) may pave a new way for the discovery of candidate vaccine molecules against schistosomiasis. Both theoretical prediction and experimental approaches conventionally used in the field of reverse vaccinology are briefly introduced in this review; and the applications of these approaches to screening and confirming candidate Schistosoma vaccine molecules are also summarized. Furthermore, potential research prospects of the application of reverse vaccinology to Schistosoma vaccine development are discussed by simulating immune effect mechanisms of immunization with radiation-attenuated cercaria vaccine in animal hosts and naturally acquired immunity in human population.
Shanghai Research Center for Biotechnology, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai 200232, China.
Xin-gang
XG
Feng
Chuan-yu
CY
Sui
Chun-xiu
CX
Yuan
Dong-hua
DH
Shao
Jin-xin
JX
Chen
Jiao-jiao
JJ
Lin
D000818:Animals; D006801:Humans; D013677:Medical Laboratory Science / Q000379:methods* / Q000639:trends; D012547:Schistosoma / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use
D014612:Vaccines