Total synthesis of (-)-barbatusol, (+)-demethylsalvicanol, (-)-brussonol, and (+)-grandione.
The icetexane-based diterpenes (-)-barbatusol, (+)-demethylsalvicanol, and (-)-brussonol were synthesized. Synthetic demethylsalvicanol was dimerized to produce (+)-grandione using aqueous Diels-Alder conditions.
Majetich
George
G
Department of Chemistry, University of Georgia, Athens, Georgia 30602, USA. majetich@chem.uga.edu
Zou
Ge
G
D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D004224:Diterpenes; C525884:barbatusol; C502780:brussonol; C516763:demethylsalvicanol; C525885:grandione