[Isosteric triphosphonate analogues of dNTP: synthesis and substrate properties toward various DNA polymerases].
Isosteric triphosphonate derivatives of 2',3'-dideoxy-2',3'-didehydroadenosine and 3'-deoxy-2',3'-didehydrothymidine and their beta,gamma-substituted analogues were synthesized. Their substrate properties toward a number of reverse transcriptases of the human immunodeficiency and bird myeloblastosis viruses, human DNA polymerases alpha and beta, and the Klenow fragment of Escherichia coli DNA polymerase I were studied.
A Iu
AIu
Skoblov
A N
AN
Semeniuk
A M
AM
Murabuldaev
V V
VV
Sosunov
L S
LS
Viktorova
Iu S
IuS
Skoblov
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D003838:Deoxyadenine Nucleotides / Q000737:chemistry*; D054306:Dideoxynucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D063065:Organophosphonates / Q000737:chemistry*; D018119:Stavudine / Q000031:analogs & derivatives* / Q000737:chemistry; D013379:Substrate Specificity
C119077:2',3'-dideoxy-2',3'-didehydroadenosine monophosphate; C113124:2',3'-dideoxy-2',3'-didehydrothymidine monophosphate; D003838:Deoxyadenine Nucleotides; D054306:Dideoxynucleotides; D063065:Organophosphonates; D000249:Adenosine Monophosphate; D018119:Stavudine; D004259:DNA-Directed DNA Polymerase