Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives.
A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 microg/mL.
Kumar Parai
Maloy
M
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
Panda
Gautam
G
Srivastava
Kumkum
K
Kumar Puri
Sunil
S
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001554:Benzene / Q000737:chemistry*; D015195:Drug Design; D007546:Isoquinolines / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000962:Antimalarials; D007546:Isoquinolines; D013449:Sulfonamides; D001554:Benzene