Evaluation of sub-microsecond recovery resonators for in vivo electron paramagnetic resonance imaging.
Time-domain (TD) electron paramagnetic resonance (EPR) imaging at 300MHz for in vivo applications requires resonators with recovery times less than 1 micros after pulsed excitation to reliably capture the rapidly decaying free induction decay (FID). In this study, we tested the suitability of the Litz foil coil resonator (LCR), commonly used in MRI, for in vivo EPR/EPRI applications in the TD mode and compared with parallel coil resonator (PCR). In TD mode, the sensitivity of LCR was lower than that of the PCR. However, in continuous wave (CW) mode, the LCR showed better sensitivity. The RF homogeneity was similar in both the resonators. The axis of the RF magnetic field is transverse to the cylindrical axis of the LCR, making the resonator and the magnet co-axial. Therefore, the loading of animals, and placing of the anesthesia nose cone and temperature monitors was more convenient in the LCR compared to the PCR whose axis is perpendicular to the magnet axis.
Hyodo
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Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA.
Subramanian
S
S
Devasahayam
N
N
Murugesan
R
R
Matsumoto
K
K
Mitchell
J B
JB
Krishna
M C
MC
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation; D051379:Mice; D008809:Mice, Inbred C3H; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D013113:Spin Labels; D013623:Tail / Q000098:blood supply*; D013673:Technology Assessment, Biomedical
D013113:Spin Labels