[Genetic epidemiological study on allergic rhinitis in Nantong region of Jiangsu Province].
OBJECTIVE
To explore the effects of genetic factors on the occurrence of allergic rhinitis (AR).


METHODS
The morbidity rate of AR was surveyed by multistage sampling among 95 300 individuals (23,825 families) in Natong region, Jiangsu province. And a genetic epidemiologic investigation on AR was carried out to estimate the segregation ratio and heritability (h2) of AR by the methods of Li-Mantel-Gart and Falconer respectively.


RESULTS
The morbidity rate of AR in Natong region was 1.20% (Male 1.21%, Female 1.18%, no statistical significance between them); By the data of the AR ancestry, the segregation ratio of AR in Nantong region was 0.078, significantly less than 0.25, and the genetic model belonged to polygenetics. The 1st, the 2nd, and the 3rd generation h2 of AR were (82.6 +/- 2.19)%, (80.8 +/- 2.93)%, (78.4 +/- 7.04)%. The h2 of AR was (81.86 +/- 1.70)%. In the ancestry of AR, the morbidity rate of the 1st generation with AR was 12.11%; the 2nd generation with AR was 5.12%; the 3rd generation with AR was 2.75%; and the morbidity rate of AR in general population was 1.20%.


CONCLUSIONS
The heredity in family with AR is obvious. Several genes plus the environmental factors may cause AR, which accords with the characteristics of the polygene heredity disease.
Department of Otorhinolaryngology, Second Affiliated Hospital, Nantong University, Nantong 226001, China. entmali@sina.com
Li
L
Ma
Da-ling
DL
Chen
Ru-xin
RX
Zhang
Xiao-lei
XL
Wang
Yun-jian
YJ
Shi
Chao
C
Ji
Zhi-jun
ZJ
Huang
Mao-hua
MH
Qian
Wei-hua
WH
Wang
Pei
P
Guan
D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D020412:Multifactorial Inheritance; D015995:Prevalence; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology* / Q000235:genetics; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000235:genetics