Atypical cutaneous lymphoid hyperplasia induced by chemotherapy in a patient with advanced colon carcinoma.
Some conditions are predisposed to excessive lymphocyte responses, which can progress to a benign condition, ie, atypical cutaneous lymphoid hyperplasia (ACLH), or a malignant lymphoma. Clinical diagnosis of drug-associated pseudolymphoma can be based on a temporal association between drug ingestion and lesion onset followed by resolution without recurrence after discontinuation of drug administration. Herein, we report the case of a 66-year-old man with advanced colon carcinoma with ACLH developed while receiving chemotherapy regimen with oxaliplatin/5-fluorouracil/leucovorin. The authors postulate that chemotherapy can promote an aberrant immune response to an antigen that can be the drug itself or other self-antigens.
Department of Oncology, S.Giovanni di Dio Hospital, Naples, Italy. lelloaddeo@alice.it
Raffaele
R
Addeo
Liliana
L
Montella
Alfonso
A
Baldi
Gregorio
G
Cennamo
Rosario
R
Guarrasi
Vincenzo
V
Faiola
Michele
M
Caraglia
Salvatore
S
Del Prete
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D016130:Immunophenotyping; D002955:Leucovorin / Q000009:adverse effects; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil