Leading the charge.
Collective cell invasion into the extracellular matrix (ECM) has been observed in malignant tumours and in tissue morphogenesis. To achieve this, leading cells trigger both proteolytic and structural modifications of the ECM to create channels that precede progressively widening chains of following cells.
Radisky
Derek C
DC
D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D045744:Cell Line, Tumor; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism* / Q000648:ultrastructure; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness
D016326:Extracellular Matrix Proteins