Dectin-1 is not required for the host defense to Cryptococcus neoformans.
Dectin-1 is known as a sole receptor for beta-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.
Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Kiwamu
K
Nakamura
Takeshi
T
Kinjo
Shinobu
S
Saijo
Akiko
A
Miyazato
Yoshiyuki
Y
Adachi
Naohito
N
Ohno
Jiro
J
Fujita
Mitsuo
M
Kaku
Yoichiro
Y
Iwakura
Kazuyoshi
K
Kawakami
D000818:Animals; D003453:Cryptococcosis / Q000276:immunology / Q000517:prevention & control*; D003455:Cryptococcus neoformans / Q000276:immunology / Q000472:pathogenicity*; D003713:Dendritic Cells / Q000276:immunology; D017353:Gene Deletion; D018664:Interleukin-12 / Q000096:biosynthesis*; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000099181:Dectin-1
D018664:Interleukin-12; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000099181:Dectin-1