Clinical and molecular characteristics of staphylococcal skin abscesses in children.
Forty-nine children with skin abscesses (36 methicillin-resistant Staphylococcus aureus and 13 methicillin-susceptible S. aureus) exhibited similar disease severity. Both pathogen groups were pulse field type USA300, multilocus sequence type 8, and possessed Panton-Valentine leukocidin genes. Related microbial genetic architecture may account for similarities in disease severity despite differences in antibiotic susceptibility.
Faden
Howard
H
Department of Pediatrics, Division of Infectious Diseases, State University of New York, Buffalo, New York, USA. hfaden@upa.chob.edu
Rose
Rebecca
R
Lesse
Alan
A
Hollands
Celeste
C
Dryja
Diane
D
Glick
Philip L
PL
D000038:Abscess / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002876:Chromosomes, Bacterial / Q000235:genetics; D017714:Community-Acquired Infections / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000235:genetics; D008245:Lysophospholipase / Q000235:genetics; D008297:Male; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012720:Severity of Illness Index; D013207:Staphylococcal Skin Infections / Q000145:classification / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity
D007956:Leukocidins; D008245:Lysophospholipase