Immune mediated neutropenia and thrombocytopenia in 3 giant schnauzers.
Neutropenia, thrombocytopenia, and splenomegaly were recognized in 3 adult female giant schnauzers. Antineutrophil antibodies were demonstrated in 2 dogs. Following splenectomy, administration of prednisone and azathioprine resulted in normalization of neutrophil and platelet numbers in all dogs.
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan. clv269@mail.usask.ca
Cheryl L
CL
Vargo
Susan M
SM
Taylor
Deborah M
DM
Haines
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D004285:Dogs; D005260:Female; D009503:Neutropenia / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D013156:Splenectomy / Q000662:veterinary; D013163:Splenomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
D019268:Antibodies, Antineutrophil Cytoplasmic; D011241:Prednisone