Bifunctional chelates for metal nuclides.
The use of ''non-standard'' metallic radionuclides continues to be an expanding field of investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles are all areas of active investigation for both diagnostic and therapeutic applications. All require a common variableaethe need for appropriate chelation chemistry for adequate sequestration of the metallic radionuclide that is equal to the intended application. A brief overview of the array of the chelation chemistry options available to researchers and the means for their selection is provided.
Brechbiel
M W
MW
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA. martinwb@mail.nih.gov
D002614:Chelating Agents / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D008670:Metals / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry
D002614:Chelating Agents; D008670:Metals; D011868:Radioisotopes; D019275:Radiopharmaceuticals