Relationship between subjective and objective cognitive function in the early and late prodrome.
BACKGROUND
Cognitive disturbances have been demonstrated in individuals with potentially prodromal symptoms in objective-neuropsychological as well as subjective-symptomatic studies. Yet, the relation between subjective and objective deficits and to different prodromal states is unclear.


OBJECTIVE
To explore interactions between subjective and objective cognitive measures in different prodromal states.


METHODS
In participants with an early (n=33) or late (n=69) initial prodromal state, cognitive subjective and objective deficits were assessed with the Schizophrenia Proneness Instrument and a comprehensive neuropsychological test battery.


RESULTS
Participants with an early initial prodromal state were less impaired than those with a late initial state. Subjective and objective cognitive deficits were unrelated, except time-limited neurocognitive speed measures and subjectively reduced stress tolerance, especially in participants with an early initial prodromal state.


CONCLUSIONS
Subjective and objective cognitive deficits are generally unrelated in the psychosis prodrome and as such they can add complementary information valuable for prediction. However, possible associations between the two levels might be better detectable in the less impaired early initial prodromal state.
Schultze-Lutter
Frauke
F
University of Cologne, Department of Psychiatry and Psychotherapy, Early Recognition and Intervention Centre for Mental Crises (FETZ), 50924 Cologne, Germany. frauke.schultze-lutter@uk-koeln.de
Ruhrmann
Stephan
S
Picker
Heinz
H
von Reventlow
Heinrich Graf
HG
Daumann
Bianca
B
Brockhaus-Dumke
Anke
A
Klosterkkötter
Joachim
J
Pukrop
Ralf
R
D000293:Adolescent; D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000523:psychology*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000523:psychology; D012647:Self-Assessment