A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations.
The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.
Jeffrey D
JD
Butler
Danielle M
DM
Solano
Lori I
LI
Robins
Makhluf J
MJ
Haddadin
Mark J
MJ
Kurth
D003500:Cyclization; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007191:Indazoles; D010078:Oxazines