A multifunctional nanoassembly of mesogen-bearing amphiphiles and porphyrins for the simultaneous photodelivery of nitric oxide and singlet oxygen.
We report a molecular nanoassembly able to supply simultaneously, in the same region of space and under the exclusive control of visible light, nitric oxide and singlet oxygen, two species playing a key role in the therapy of cancer; the considerable fluorescence of this nanoaggregate and its reduced size (ca. 40 nm) represent additional advantages that make this photoactive vehicle an appealing candidate to be tested in biological systems.
Dipartimento di Scienze Chimiche, Universitá di Catania, Viale Andrea Doria 8, Catania, I-95125, Italy.
Elisa B
EB
Caruso
Enzo
E
Cicciarella
Salvatore
S
Sortino
D000669:Amplifiers, Electronic; D004553:Electric Conductivity; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D010777:Photochemistry; D011166:Porphyrins / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D012996:Solutions; D013053:Spectrophotometry
D008823:Micelles; D011166:Porphyrins; D012996:Solutions; D026082:Singlet Oxygen; D009569:Nitric Oxide