Apolipoprotein E phenotype in demented patients in Greek population.
Apolipoprotein E is a plasma protein, involved in the transport of lipids and their metabolism. The aim of this investigation was to correlate the ApoE phenotypes with the type and the severity of dementia in Greek demented patients. The investigation revealed that 72% of the patients have the E3/3 phenotype, but only 11% of them demonstrated the E3/2; 13% of the patients have the E4/3 phenotype and only 4% of them demonstrated the phenotype E4/4. The most severely demented patients corresponded to e4 alléle. The present results indicate that the most common ApoE phenotype in Greek demented patients is E3/3.
Neuropathological Laboratory of the 1st Department of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece.
Eleni
E
Hatzifilippou
Tania
T
Banaki
Maria
M
Traka
Ephrosyni
E
Koutsouraki
Vassiliki
V
Costa
Stavros J
SJ
Baloyannis
D000368:Aged; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000145:classification / Q000235:genetics*; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012720:Severity of Illness Index
D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E