Notch signaling in leukemia.
Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.
Aster
Jon C
JC
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. jaster@partners.org
Pear
Warren S
WS
Blacklow
Stephen C
SC
D000818:Animals; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*
D009363:Neoplasm Proteins; D051881:Receptor, Notch1