Network-centered view of coronary artery disease.
Systems biology is an emerging field that attempts to examine multiple elements of a biologic system using techniques such as expression microarrays or proteomics. The goal of systems biology is to detect all the elements of a system and create an interaction network between these so that the system can be explained under specified conditions. In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties.
Bennett
Brian J
BJ
Department of Medicine, University of California, Los Angeles, CA 90095-1679, USA. bbennett@mednet.ucla.edu
Romanoski
Casey E
CE
Lusis
Aldons J
AJ
D000818:Animals; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D008297:Male; D051379:Mice; D040901:Proteomics / Q000379:methods; D012680:Sensitivity and Specificity; D049490:Systems Biology