Claudin proteins in ovarian cancer.
Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for detection and prognosis, as well as ideal targets for therapy using the Clostridium perfringens enterotoxin.
Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Morinp@grc.nia.nih.gov
Patrice J
PJ
Morin
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis* / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D011379:Prognosis; D019108:Tight Junctions / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D008565:Membrane Proteins