2-Aminoresorcinol is a potent alpha-glucosidase inhibitor.
A series of aminoresorcinols and related compounds were tested for rat intestinal alpha-glucosidase inhibition and these results suggested that the 2-aminoresorcinol moiety of 6-amino-5,7-dihydroxyflavone (2) is important to exert the intestinal alpha-glucosidase inhibitory activity and 2-aminoresorcinol (4), itself, is a potent alpha-glucosidase inhibitor and inhibited sucrose-hydrolyzing activity of rat intestinal alpha-glucosidase uncompetitively.
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Hong
H
Gao
Jun
J
Kawabata
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D051381:Rats; D012118:Resorcinols / Q000737:chemistry* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D012118:Resorcinols; C031389:resorcinol