A hypothetical biological synovial fluid for treatment of temporomandibular joint disease.
Temporomandibular Joint disorder (TMD) is a common disorder of mandibular motion system with distinct clinicopathological characteristics. TMD may cause to change in the components of synovial fluid, that affects the functions on lubrication and nutrition of cartilage. Boundary lubrication system contributing to the low friction of joint consists of three parts: lubricin, surface-active phospholipids and hyaluronan (HA). Diminishment of lubrication function is thereby implicated as an adverse contributing factor in degenerative joint diseases such as internal derangement, osteoarthrosis. Moreover, mesenchymal stem cells (MSCs) of synovial membrane can be obtained without irreversible damage, are easily expandable with limited senescence. We postulate that biological active components secreted from MSCs are separated and accumulated by gel permeation chromatography, and then we use the ultra-flirtation of serum and biologically active components to reconstruct the biological synovial fluid in order to rehabilitate the boundary lubrication system and the nutrition of cartilage. Further study investigating the components of biological synovial fluid provides with new treatment strategy for TMD.
Meng
Qing-Gong
QG
Department of Oral and Maxillofacial Surgery, Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, PR China.
Long
Xing
X
D000818:Animals; D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence; D004195:Disease Models, Animal; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008954:Models, Biological; D008962:Models, Theoretical; D010003:Osteoarthritis / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry; D013582:Synovial Fluid / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000473:pathology* / Q000628:therapy*
D010743:Phospholipids; D006820:Hyaluronic Acid