Antimicrobial effects of flavone analogues and their structure-activity relationships.
It has been well known that the use of Saccharomyces cerevisiae can cause fungemia in critically ill patients and flavone shows an antimicrobial effect on S. cerevisiae. Therefore, we have investigated the activities of thirteen flavone analogues on S. cerevisiae in our studies. Because flavonoids including flavones have antioxidative effects, we try to carry out the activity studies of flavone analogues in vitro and in vivo. In addition, the relationships between the structures of flavone analogues and their biological activities, such as antimicrobial and antioxidative effects, were elucidated using Comparative Molecular Field Analysis calculations. Of the flavone analogues tested here, 3,2'-dihydroxyflavone showed both good antimicrobial and antioxidative activities.
Bio/Molecular Informatics Center Department ofBioscience and Biotechnology, IBST Konkuk University, Seoul 143-701, Korea.
Jungmo
J
Young
Younghee
Y
Park
Yong-Uk
YU
Lee
Hojung
H
Kim
Yhong-Hee
YH
Shim
Joong-Hoon
JH
Ahn
Yoongho
Y
Lim
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D008958:Models, Molecular; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D055672:Static Electricity; D013329:Structure-Activity Relationship
C526335:3,2'-dihydroxyflavone; D000935:Antifungal Agents; D000975:Antioxidants; D005419:Flavonoids