Behçet's disease: ocular effects and treatment.
Behçet's disease (BD) is a systemic immune-mediated vasculitis of unclear origin. Major symptoms include oral aphthous ulcers, genital ulcerations, skin lesions, and ocular lesions. Eye involvement, which affects 60-80% of BD patients, is characterized by posterior or panuveitis with occlusive retinal vasculitis. The pathogenesis of BD remains unclear, but research of the last decades has shown a complex role of genetic factors (HLA-B51) predisposing to inflammation with involvement of the innate-immune system (neutrophils, NK cells), perpetuated by the adaptive immune response, most importantly T cells, against infectious- and/or auto-antigens. Despite aggressive immunosuppressive treatment, the visual prognosis of ocular BD was generally poor to date. Recently, novel biologic drugs, including interferon-alpha and tumour necrosis factor (TNF)-alpha-antagonists have been introduced in the treatment of ocular BD with very promising results and seem for the first time to improve the prognosis of the disease. This article will provide a current review of BD including recent developments in epidemiology, immunology, genetics, and treatment.
Deuter
Christoph M E
CM
Centre for Ophthalmology, University Eye Hospital, University of Tübingen, Schleichstrasse 12, 72076 Tübingen, Germany. christoph.deuter@med.uni-tuebingen.de
Kötter
Ina
I
Wallace
Graham R
GR
Murray
Philip I
PI
Stübiger
Nicole
N
Zierhut
Manfred
M
D001528:Behcet Syndrome / Q000150:complications*; D006801:Humans; D015994:Incidence; D012164:Retinal Diseases / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D014605:Uveitis / Q000453:epidemiology / Q000209:etiology*