Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.
The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressure values despite lack of white adipose tissue and its hormones. Furthermore, A-ZIP/F-1 lipoatrophic mice have a significant reduction of adrenal zona glomerulosa, while plasma aldosterone levels and aldosterone synthase mRNA expression remain unchanged. On the other hand, lipoatrophic mice present elevated corticosterone levels but no adrenocortical hyperplasia. Ultrastructural analysis of adrenal gland show significant alterations in adrenocortical cells, with conformational changes of mitochondrial internal membranes and high amounts of liposomes. In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes.
Lamounier-Zepter
Valeria
V
Department of Internal Medicine III, University Medical Center, University of Dresden, 01307 Dresden, Germany. valeria.zepter@uniklinikum-gresden.de
Bornstein
Stefan R
SR
Kunes
Jaroslav
J
Zicha
Jozef
J
Krsek
Michal
M
Ehrhart-Bornstein
Monika
M
Ziegler
Christian G
CG
Kiessling
Andrea
A
Funk
Richard H
RH
Haluzik
Martin
M
D054392:Adipokines / Q000097:blood; D052436:Adipose Tissue, White / Q000378:metabolism* / Q000473:pathology; D000302:Adrenal Cortex / Q000000981:diagnostic imaging / Q000201:enzymology / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003345:Corticosterone / Q000097:blood; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics / Q000378:metabolism; D003923:Diabetes Mellitus, Lipoatrophic / Q000150:complications* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006973:Hypertension / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D051336:Mitochondrial Membranes / Q000378:metabolism / Q000648:ultrastructure; D012333:RNA, Messenger / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014463:Ultrasonography; D015384:Zona Glomerulosa / Q000378:metabolism
D054392:Adipokines; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D012333:RNA, Messenger; C406806:Tg(AZIP-F)1Vsn protein, mouse; D014157:Transcription Factors; D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2; D003345:Corticosterone