Migration of dendritic cell subsets and their precursors.
The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a consequence of their localization within tissues and their specialized capacity for mobilization. The migration of a given DC subset is typified by a restricted capacity for recirculation, contrasting markedly with T cells. Routes of DC migration into lymph nodes differ notably for distinct DC subsets. Here, we compare the distinct migratory patterns of plasmacytoid DCs (pDCs), CD8alpha(+) DCs, Langerhans cells, and conventional myeloid DCs and discuss how the highly regulated patterns of DC migration in vivo may affect their roles in immunity. Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration.
Department of Gene and Cell Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA. gwendalyn.randolph@mssm.edu
Gwendalyn J
GJ
Randolph
Jordi
J
Ochando
Santiago
S
Partida-Sánchez
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D002633:Chemotaxis / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008196:Lymph / Q000166:cytology; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology