Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy.
OBJECTIVE
To examine the effects of prenatal stress on cognition and behavioral fearfulness in infants.


METHODS
Mothers were recruited at amniocentesis at Queen Charlotte's and Chelsea Hospital, London, between 2001 and 2005, and recalled when their children were 14 to 19 months to assess cognitive development using the Bayley Scales and fearfulness using the Lab-TAB. Measures of prenatal and postnatal life events and current psychological state were collected at the postnatal visit.


RESULTS
Prenatal stress predicted both mental development (rs = -0.39, n = 123 p < .0001) and observed fearfulness (rs = 0.33, n = 106, p < .001); the magnitude of effect was essentially unchanged after covarying postnatal stressors, maternal education and psychological state, exposures to medications and substances during pregnancy, and birth outcomes. Prenatal stress accounted for 17% of the variance in cognitive ability and 10% of the variance in observed fearfulness. The correlation between mental development and fearfulness was minimal (r = -0.06, not significant). Prenatal partner relationship strain accounted for 73.5% and 75.0% of the prenatal stress related variance on infant cognitive and fearfulness scores, respectively.


CONCLUSIONS
These findings strengthen previous research that suggests that fetal programming can be important for neurodevelopmental and psychiatric outcomes. They imply that the mechanisms by which mental development and fearfulness are affected are different and that prenatal stress due to relationship strain may warrant particular attention.
Imperial College London, UK
Kristin
K
Bergman
Pampa
P
Sarkar
Thomas G
TG
O'Connor
Neena
N
Modi
Vivette
V
Glover
D000328:Adult; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005239:Fear; D005260:Female; D006801:Humans; D007223:Infant; D008016:Life Change Events; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data*; D010698:Phobic Disorders / Q000175:diagnosis / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D013315:Stress, Psychological / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D011795:Surveys and Questionnaires