Immune mediated neutropenia and thrombocytopenia in 3 giant schnauzers.
Neutropenia, thrombocytopenia, and splenomegaly were recognized in 3 adult female giant schnauzers. Antineutrophil antibodies were demonstrated in 2 dogs. Following splenectomy, administration of prednisone and azathioprine resulted in normalization of neutrophil and platelet numbers in all dogs.
Vargo
Cheryl L
CL
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan. clv269@mail.usask.ca
Taylor
Susan M
SM
Haines
Deborah M
DM
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D004285:Dogs; D005260:Female; D009503:Neutropenia / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D013156:Splenectomy / Q000662:veterinary; D013163:Splenomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
D019268:Antibodies, Antineutrophil Cytoplasmic; D011241:Prednisone