Electrical impedance scanning as a new breast cancer risk stratification tool for young women.
BACKGROUND
Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women).


OBJECTIVE
To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman.


METHODS
A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (S(p))-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)S(n))-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability.


RESULTS
In the S(p)-Cohort, 93 of 1,751 women were T-Scan+ (S(p) = 94.7%; 95% CI: 93.7-95.7%). In the S(n)-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (S(n) = 26.4%; 95% CI: 17.4-35.4%). Given S(p) = 94.7%, S(n) = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14).


CONCLUSIONS
EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.
Stojadinovic
Alexander
A
Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA. alexander.stojadinovic@na.amedd.army.mil
Nissan
Aviram
A
Shriver
Craig D
CD
Mittendorf
Elizabeth A
EA
Akin
Mark D
MD
Dickerson
Vivian
V
Lenington
Sarah
S
Platt
Lawrence D
LD
Stavros
Thomas
T
Goldstein
Steven R
SR
Moskovitz
Orah
O
Gallimidi
Zahava
Z
Fields
Scott I
SI
Yeshaya
Arieh
A
Allweis
Tanir M
TM
Manassa
Raymond
R
Pappo
Itzhak
I
Ginor
Ron X
RX
D'Agostino
Ralph B
RB
Gur
David
D
D000328:Adult; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D015331:Cohort Studies; D017097:Electric Impedance; D004568:Electrodiagnosis / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D017697:Premenopause / Q000502:physiology; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity