Therapeutic targets in respiratory viral infections.
Respiratory viral infections account for a substantial proportion of morbidity world wide and contribute notably to the socio-economic burden of diseases. Amongst the most important viruses identified so far are Rhinoviruses, Influenza A and Respiratory Syncytial Virus. The knowledge base has broadened at the clinical and experimental level in recent years. However, therapeutic options are still limited. This may be partly due to the multiplicity of infectious mechanisms and the complex underlying host/virus interactions. The aim of this article is to give an overview of the different respiratory viruses involved, their major principles of infection and the associated therapeutic targets and to review up-to-date virus-specific clinical trials.
University Hospital Bergmannsheil, Ruhr-University Bochum, Germany. gernot.rohde@ruhr-uni-bochum.de
Gernot
G
Rohde
D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D012327:RNA Virus Infections / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000187:drug effects* / Q000502:physiology; D012137:Respiratory System / Q000821:virology; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology; D012229:Rhinovirus / Q000187:drug effects* / Q000502:physiology; D014765:Viral Vaccines
D000998:Antiviral Agents; D014765:Viral Vaccines