The risk of antimalarials in patients with renal failure.
We present here a patient with end stage renal failure who received two weeks antimalarial prophylaxis at full dose leading to life threatening toxicity with severe acute megaloblastic anaemia, symptomatic pancytopenia and exfoliative dermatitis. Prompt recognition and treatment can rapidly reverse these fatal effects but more importantly, education of patients before travel is imperative in preventing such events.
Princess Alexandra Hospital, Harlow, Essex, UK.
N
N
Thorogood
S
S
Atwal
W
W
Mills
M
M
Jenner
D A
DA
Lewis
J D
JD
Cavenagh
S G
SG
Agrawal
D000328:Adult; D000749:Anemia, Megaloblastic / Q000139:chemically induced*; D000962:Antimalarials / Q000009:adverse effects*; D002738:Chloroquine / Q000009:adverse effects; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008288:Malaria / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*; D002727:Proguanil / Q000009:adverse effects
D000962:Antimalarials; D002738:Chloroquine; D002727:Proguanil