Opposing effects of Wnt and MAPK on BMP/Smad signal duration.
Signaling downstream of BMP receptors relies on activated nuclear Smad proteins. Recent studies, one of which is published in the November 30 issue of Cell, shed light on a mechanism that balances inputs from both activated MAPK and Wnt pathways to regulate the proteasomal degradation of Smad1 and thus modulate the extent of BMP signaling.
Verheyen
Esther M
EM
Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. everheye@sfu.ca
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D051153:Wnt Proteins; D020928:Mitogen-Activated Protein Kinases