[The safety of enoxaparine use in elderly with acute myocardial infarction].
OBJECTIVE
Enoxaparin (ENOX), the low-molecular-weight heparin, used in acute myocardial infarction (AMI) could lead to hemorrhage. The aim of this study was to determine wether bleeding was more often in AMI patients older than 65 or 75 years who receive ENOX or unfractionated heparin (UFH).


METHODS
Among the patients with AMI hospitalized during three successive months receiving ENOX or UFH, three group of parameters were investigated: demographic, ischemic and bleeding TIMI criteria.


RESULTS
Among 85 hospitalized patients with signs of AIM, there were 35 (41.2%) old 65 years or less, 32 (38.5) old 66-75 years and 18 (21.2%) older than 75 years. In AMI elderly patients, according to the received ENOX/UFH: ischemic complication (18.2 vs. 21.4%) were insignificantly lower and the number of lethal outcomes (18.2 vs. 17.8%) were insignificantly more often in ENOX group; represented only by one patient (age beyond 75 years), major and non-major bleeding events occurred only in UFH group.


CONCLUSIONS
The ENOX usage in AMI in patients older than 65 years did not show any significant difference in efficacy and bleeding rate comparing to UFH.
Klinicko-bolnicki centar Zvezdara, Centar za kardiovaskularne bolesti, Beograd, Srbija.
Nebojsa
N
Despotović
Goran
G
Loncar
Maja
M
Nikolić-Despotović
Marjan
M
Ilicć
Sinisa
S
Dimković
D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D017984:Enoxaparin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*
D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin