Childhood sexual and physical abuse histories, PTSD, depression, and HIV risk outcomes in women injection drug users: a potential mediating pathway.
We explored links between childhood sexual abuse (CSA), childhood physical abuse (CPA), posttraumatic stress disorder (PTSD)/depression, and women injection drug users' (IDUs') risk in 113 women recruited from two syringe exchange sites. More than half (56%) reported CSA, 68% CPA, 23% likely were depressed-only, and 53% likely had PTSD/depression. CSA was associated with sexual (p = 0.003) and drug risk (p = 0.05); CPA was not. CSA was associated with PTSD/depression (p = 0.03); PTSD/depression was associated with sexual (p < 0.01) and drug (p < 0.03) risk. After PTSD/depression adjustment, CSA was no longer associated with sexual or drug risk. These results suggest that women IDUs' CSA-to-risk path is mediated by PTSD/depression.
Plotzker
Rosalyn E
RE
Center for the Studies of Addiction, HIV Prevention Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA.
Metzger
David S
DS
Holmes
William C
WC
D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002649:Child Abuse / Q000523:psychology / Q000706:statistics & numerical data*; D002650:Child Abuse, Sexual / Q000523:psychology / Q000706:statistics & numerical data*; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D008875:Middle Aged; D015233:Models, Statistical; D016485:Needle Sharing / Q000523:psychology / Q000706:statistics & numerical data; D018671:Needle-Exchange Programs / Q000706:statistics & numerical data; D016017:Odds Ratio; D010555:Personality Inventory; D012309:Risk-Taking; D012737:Sex Factors; D012725:Sexual Behavior / Q000523:psychology* / Q000706:statistics & numerical data; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology* / Q000523:psychology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology / Q000523:psychology*; D011795:Surveys and Questionnaires