Facile access to pyrazolines via domino reaction of the Huisgen zwitterions with aziridines.
A novel, efficient, and general domino reaction of 2-acylaziridines with the Huisgen zwitterions to furnish 2-pyrazoline rings is described. A possible mechanism for the domino sequence is proposed.
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Sun-Liang
SL
Cui
Jing
J
Wang
Yan-Guang
YG
Wang
D001388:Aziridines / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001388:Aziridines; D007202:Indicators and Reagents; D011720:Pyrazoles