The interplay between MYC and HIF in cancer.
The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia). Many tumours contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumour cells, which tend to exist in a hypoxic microenvironment. This Perspective emphasizes the differences between the transcriptional network that operates under normal homeostatic conditions and the network in a tumorigenic milieu.
Dang
Chi V
CV
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cvdang@jhmi.edu
Kim
Jung-whan
JW
Gao
Ping
P
Yustein
Jason
J
D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D016259:Genes, myc; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D051793:Hypoxia-Inducible Factor 1; D000099162:Endothelial PAS Domain-Containing Protein 1