IFN regulation and functions in myeloid dendritic cells.
A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC. This knowledge may have important therapeutic implications in infectious and neoplastic diseases and open new perspectives in the use of IFNs as vaccine adjuvants and in the development of DC-based vaccines.
Coccia
Eliana Marina
EM
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy. eliana.coccia@iss.it
D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000502:physiology; D007370:Interferon Type I / Q000235:genetics / Q000502:physiology*; D020365:RNA Helicases / Q000502:physiology; D053633:Receptor, Interferon alpha-beta / Q000502:physiology; D011971:Receptors, Immunologic; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
C507964:IFNAR1 protein, human; D050835:Interferon Regulatory Factors; D007370:Interferon Type I; D011971:Receptors, Immunologic; D050791:STAT Transcription Factors; D051193:Toll-Like Receptors; D053633:Receptor, Interferon alpha-beta; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases