[Uterine abnormalities in non menopausal women who received tamoxifen for breast cancer adjuvant therapy].
OBJECTIVE
To elaborate a strategy of endometrial follow-up for premenopausal women treated with Tamoxifen as adjuvant hormonal treatment of breast cancer.


METHODS
Retrospective study of 152 premenopausal patients treated with Tamoxifen in Nantes Comprehensive Cancer Center for a breast cancer from January 2003 to December 2005. Vaginal sonography was used in the follow-up of 70 of them.


RESULTS
Endometrial hypertrophy was found in 26 patients. Sonohysterography and hysteroscopy allowed to find 11 polyps and three hyperplasias in the 19 women who were investigated. In our study, endometrial pathology was found in 20% of premenopausal women treated with Tamoxifen (polyps or hyperplasia). Uterine bleeding was found in half patient of this group.


CONCLUSIONS
Vaginal sonography monitoring could be proposed to premenopausal women treated with Tamoxifen among whom endometrial pathology is usual.
Service de chirurgie oncologique, centre régional de lutte contre le cancer René-Gauducheau, boulevard Jean-Monod, 44805 Saint Herblain, France.
A-S
AS
d'Arailh
T
T
Michy
R
R
Pioud
F
F
Dravet
J-M
JM
Classe
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D004714:Endometrial Hyperplasia / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D011127:Polyps / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen