New polyphenols active on beta-amyloid aggregation.
New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.
Laboratoire de physique et biophysique, Institut des Sciences de Vigne et du Vin, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
Céline
C
Rivière
Tristan
T
Richard
Xavier
X
Vitrac
Jean-Michel
JM
Mérillon
Josep
J
Valls
Jean-Pierre
JP
Monti
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000187:drug effects* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D013056:Spectrophotometry, Ultraviolet
D016229:Amyloid beta-Peptides; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols