Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.
Parihar
Mordhwaj S
MS
Department of Surgery, Davis Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, OH, USA.
Nazarewicz
Rafal R
RR
Kincaid
Erick
E
Bringold
Urs
U
Ghafourifar
Pedram
P
D000818:Animals; D002478:Cells, Cultured; D042967:Electron Transport Complex I / Q000378:metabolism*; D004789:Enzyme Activation; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*; D013223:Statistics as Topic
D024101:Mitochondrial Proteins; D019001:Nitric Oxide Synthase; D042967:Electron Transport Complex I