Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.
The levels of fibroblast growth factor (FGF) signaling play important roles in coordinating development of the mouse inner, middle, and outer ears. Extracellular signal-regulated kinases (ERKs) are among the effectors that transduce the FGF signal to the nucleus and other cellular compartments. Attenuation of ERK activity by dephosphorylation is necessary to modulate the magnitude and duration of the FGF signal. Recently, we showed that inactivation of the ERK phosphatase, dual specificity phosphatase 6 (DUSP6), causes partially penetrant postnatal lethality, hearing loss and skeletal malformations. To determine whether other Dusps may function redundantly with Dusp6 during otic development, we surveyed the expression domains of the three ERK-specific DUSP transcripts, Dusp6, Dusp7, and Dusp9, in the embryonic mouse ear. We show that each is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112-5330, USA.
Lisa D
LD
Urness
Chaoying
C
Li
Xiaofen
X
Wang
Suzanne L
SL
Mansour
D000818:Animals; D054642:Dual Specificity Phosphatase 6 / Q000235:genetics*; D054637:Dual-Specificity Phosphatases / Q000235:genetics*; D004423:Ear / Q000196:embryology*; D004431:Ear, External / Q000196:embryology / Q000378:metabolism; D007758:Ear, Inner / Q000196:embryology / Q000378:metabolism; D004432:Ear, Middle / Q000196:embryology / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D017403:In Situ Hybridization; D051379:Mice; D015398:Signal Transduction / Q000235:genetics
D048049:Extracellular Signal-Regulated MAP Kinases; D054642:Dual Specificity Phosphatase 6; D054637:Dual-Specificity Phosphatases; C517036:Dusp6 protein, mouse; C529383:Dusp7 protein, mouse; C484491:Dusp9 protein, mouse