The frequency of angiotensin-converting enzyme genotype and left ventricular functions in the obese population.
The authors investigated the relationship between angiotensin-converting enzyme (ACE) genotype and left ventricular functions in an obese population and compared their findings with controls. Ninety-six obese patients and 50 controls were enrolled. Obesity was subgrouped into mild (body mass index [BMI] 25-29.9 kg/m(2)), moderate (BMI 30-34.9 kg/m(2)), and significant (BMI > or =35 kg/m(2)). Body fat distribution was categorized according to waist-to-hip ratio and waist circumference. Left ventricular systolic and diastolic functions were evaluated by echocardiography. ACE gene polymorphism was investigated by standard polymerase chain reaction, and frequency distributions were calculated for the subgroups. Systolic functional indices were found to be increased in mild and moderate obesity subgroups. The obese population had increased left ventricular diameters. None of the patients had systolic dysfunction, while diastolic dysfunction was significantly more common in the obese group; the frequency of diastolic dysfunction was proportionally increased with body mass index. Diastolic dysfunction was more common in persons with abdominal obesity. ACE DD genotype frequency was increased in moderately and significantly obese subgroups and also in all obese patients with diastolic dysfunction.
Bitigen
Atila
A
Cardiology Department, Kosuyolu Heart and Research Hospital, Istanbul, Turkey.
Cevik
Cihan
C
Demir
Durmus
D
Tanalp
Ali Cevat
AC
Dundar
Cihan
C
Tigen
Kursat
K
Mutlu
Bulent
B
Basaran
Yelda
Y
D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000235:genetics; D016277:Ventricular Function, Left / Q000502:physiology*
D007703:Peptidyl-Dipeptidase A