Disinfection of dentinal tubules with 2% chlorhexidine, 2% metronidazole, bioactive glass when compared with calcium hydroxide as intracanal medicaments.
Thorough disinfection of the root canal system is essential for the success of root canal therapy. This requires the use of an intra-canal medicament. Enterococcus faecalis is the most frequently found species in persistent/secondary intracanal infection associated endodontic treatment failure. This study evaluates the disinfection of dentinal tubules using 2% chlorhexidine gel, 2% metronidazole gel, bioactive glass (S53P4) in comparison with calcium hydroxide. The antibacterial efficacy of the four medicaments against Enterococcus faecalis was assessed in vitro using extracted premolar teeth at the depths of 200 microm and 400 microm. The overall percentage inhibition of bacterial growth (at 200 microm and 400 microm depth) was 100% with 2% chlorhexidine gel. The inhibition of growth was moderate with 2% metronidazole gel (86.5%), followed by bioactive glass (62.8%) and calcium hydroxide (58.5%). It can be concluded from the present study that 2% chlorhexidine gel alone was most effective against E. faecalis when compared to other medicaments tested.
Krithikadatta
Jogikalmat
J
Department of Conservative Dentistry & Endodontics, Meenakshi Ammal Dental College, Maduravoyal, India. drkrithikadatta@hotmail.com
Indira
Rajamani
R
Dorothykalyani
Alfred Leo
AL
D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002126:Calcium Hydroxide / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage; D003804:Dentin / Q000382:microbiology*; D004338:Drug Combinations; D013293:Enterococcus faecalis / Q000187:drug effects*; D005898:Glass; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D012388:Root Canal Irrigants / Q000008:administration & dosage*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D012388:Root Canal Irrigants; C403922:bioactive glass S53P4; D008795:Metronidazole; D002126:Calcium Hydroxide; D002710:Chlorhexidine