Viral elements sense tumorigenic processes: approaching selective cancer therapy.
Viruses can produce viral oncoproteins that drive multiple genetic alterations as the consequence of neoplastic transformation. Viral proteins encoded by onco-related viruses such as polyomavirus SV40 or Epstein-Barr virus are involved in cellular processes resulting in imbalance between proliferation and cell death, knowledge of which continues to be crucial for combating cancer. On the other hand, viruses also generate viral components that, from a cold viral protein, can become a tumor-selective killer by sensing cellular tumorigenic hallmarks. For instance, the avian virus derived apoptin protein has been proven to induce tumor-regression in various pre-clinical animal models without showing detectable side effects. In particular, apoptin-interacting protein partners such as components of the anaphase promoting complex were identified as potential anticancer drug targets. The adenovirus-derived protein E4orf4, another viral protein with tumor-specific apoptosis characteristics, has been proven to interact with the tumor-suppressor protein phosphatase 2A. This review aims to describe recent studies with representative viral elements that have contributed to our understanding of critical tumorigenic processes and have conferred an impact on the development of novel anti-cancer therapies.
Biological Chemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Klaas
K
Kooistra
Ying-Hui
YH
Zhang
Mathieu H M
MH
Noteborn
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D036022:Capsid Proteins / Q000187:drug effects / Q000494:pharmacology / Q000502:physiology*; D004742:Enhancer Elements, Genetic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D054648:Protein Phosphatase 2 / Q000378:metabolism; D015398:Signal Transduction; D013539:Simian virus 40 / Q000502:physiology*; D014764:Viral Proteins / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D000970:Antineoplastic Agents; D036022:Capsid Proteins; C121517:E4orf4 protein, adenovirus; C091717:VP3 protein, Chicken anemia virus; D014764:Viral Proteins; D054648:Protein Phosphatase 2