Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies.
OBJECTIVE
To evaluate clinical outcomes following lateral temporal bone resection (LTBR) for management of malignancies involving the ear or temporal bone.


METHODS
A retrospective medical record review was performed on patients receiving LTBR for management of malignancies involving the ear or temporal bone between 1990 and 2007.


RESULTS
In this group of 35 patients, the mean age was 62.7 years, with tumor histopathologies including squamous cell carcinoma (SCC, 20), basal cell carcinoma (BCC, 7), adenoid cystic carcinoma (ACC, 7), and adenocarcinoma (1). The 5-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 77%, 79%, and 52%, respectively. Complete resection resulted in improved OS, DSS, and DFS (P < 0.004 for each) and reduced local recurrence (P < 0.001).


CONCLUSIONS
In patients with carcinomas of the ear and temporal bone, upfront excision including LTBR is an effective management when combined with postoperative radiation therapy. Complete removal of all disease may improve survival and decrease recurrence.
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA. mgmoore@gmail.com
Michael G
MG
Moore
Daniel G
DG
Deschler
Michael J
MJ
McKenna
Mark A
MA
Varvares
Derrick T
DT
Lin
D000230:Adenocarcinoma / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D018572:Disease-Free Survival; D004424:Ear Canal / Q000601:surgery; D004428:Ear Neoplasms / Q000601:surgery*; D004431:Ear, External / Q000601:surgery; D004432:Ear, Middle / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010306:Parotid Gland / Q000601:surgery; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000601:surgery*; D015996:Survival Rate; D013701:Temporal Bone / Q000601:surgery*; D016896:Treatment Outcome