Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities.
It was questioned whether amygdala kindling, a model of temporal lobe epilepsy, is under genetic control, and is associated with comorbid behavioral features. Initially, rats were selectively bred for speed of amygdala kindling, and, in subsequent generations, were assessed in behavioral paradigms to measure activity, emotionality, impulsivity, and learning. Clearly kindling was under genetic control, as two strains were developed to be either Fast or Slow to kindle, and each was associated with different neurological, electrophysiological and behavioral features. Behaviorally, the Fast rats appear much like humans with attention deficit hyperactivity disorder (ADHD), showing easy distraction, hyperactivity and impulsivity, compared to Slow rats.
McIntyre
Dan C
DC
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada. Dan_McIntyre@carleton.ca
Gilby
Krista L
KL
D000679:Amygdala / Q000469:parasitology* / Q000502:physiology* / Q000503:physiopathology*; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics; D001522:Behavior, Animal / Q000502:physiology; D001947:Breeding / Q000379:methods; D015897:Comorbidity; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007696:Kindling, Neurologic / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics*; D012641:Selection, Genetic