Highly enantioselective aza-Henry reaction of N-tosyl imines catalyzed by N,N'-dioxide-Cu(I) complexes.
The N,N'-dioxide-Cu(I) complexes have been developed to catalyze the addition of nitromethane to N-tosyl aldimines. The aza-Henry reaction proceeds smoothly affording the corresponding nitro amines in good yields with high enantioselectivities. A catalytic cycle is proposed to explain the origin of reactivity.
Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Hui
H
Zhou
Dan
D
Peng
Bo
B
Qin
Zongrui
Z
Hou
Xiaohua
X
Liu
Xiaoming
X
Feng
D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D001372:Aza Compounds; D007097:Imines; D009942:Organometallic Compounds; D003300:Copper