Posttraumatic stress disorder with secondary psychotic features: neurobiological findings.
The neurobiological knowledge on the potentially new diagnostic entity "posttraumatic stress disorder with secondary psychotic features" (PTSD-SP) is reviewed. Studies published between 1980 and 2006 were traced focussing on adult patients suffering from this "syndrome". Studies on cortisol, corticotrophin releasing hormone, dopamine beta-hydroxylase, smooth pursuit eye movements and psychopharmacology are described and potential pathophysiological mechanisms briefly discussed. More research is needed to validate the nosological status of PTSD-SP in order to promote neurobiological research and adequate therapeutic interventions.
Institute of Mental Health Care, Wolfheze, the Netherlands and Department of Psychiatry, Radboud University Nijmegen Medical Center, Wolfheze 2, 6874 BE, Wolfheze, The Netherlands. m.braakman@degelderseroos.nl
Mario H
MH
Braakman
Frank A M
FA
Kortmann
Wim
W
van den Brink
Robbert J
RJ
Verkes
D015415:Biomarkers; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D011618:Psychotic Disorders / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D011698:Pursuit, Smooth / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*
D015415:Biomarkers; D003346:Corticotropin-Releasing Hormone; D004299:Dopamine beta-Hydroxylase; D006854:Hydrocortisone