Involvement of vascular endothelial growth factor on spermatogenesis in testis with varicocele.
The expression and the role of vascular endothelial growth factor in human testes with varicocele were examined. Vascular endothelial growth factor expression was increased in testes with varicocele, and was inversely correlated with total motile sperm count and testicular volume, indicating that excessive vascular endothelial growth factor has harmful effects on spermatogenesis in testes with varicocele.
Shiraishi
Koji
K
Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan. sirakkkay@aol.com
Naito
Katsusuke
K
D000328:Adult; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D013076:Sperm Count; D013094:Spermatozoa / Q000378:metabolism* / Q000473:pathology*; D013737:Testis / Q000378:metabolism* / Q000473:pathology*; D014646:Varicocele / Q000378:metabolism* / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A