[Are IL2 receptor antagonist useful in high risk acute tubular necrosis kidney recipients?].
The questions are if old recipients from old donor have more incidence of delayed graft function and if antagonists of Il-2 receptors use decreased the incidence of NTA post-transplant. To answer the first question we have come to information from registry and uni or multicenter studies. We have used the Irish normograme that included 16 clinical questions from donors, recipients and kidney transplant. We concluded that age of donors increases likelihood of delayed graft function. The second question is answered in the literature with information of a meta-analysis with 38 clinical studies. Of them 9 (1.380 patients) studied delayed graft function and are against placebo. The odds ratio for delayed graft function was 0.87(IC 95% 0,72 a 1,06). Therefore, at the moment, we can conclude that the utilization of antagonists of Il-2 receptors does not have protective effect to NTA.
Servicio de Nefrología, Hospital Ramó y Cajal, Madrid.
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Fernández
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Royuela
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Quintás
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Zamora
D000368:Aged; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology* / Q000517:prevention & control*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000037:antagonists & inhibitors*; D012307:Risk Factors
D015375:Receptors, Interleukin-2