Aortic and mitral valve replacement in a patient with hemophilia B.
A 25-year-old man with factor IX deficiency had an aortic and mitral valve replacement using a 2M Starr Edwards valve in the mitral position and a 22 Medtronic valve in the aortic position under cover of factor IX concentrate. The surgical procedure and the immediate postoperative period were uneventful except for a pericardial effusion which required a pericardiostomy. He was anticoagulated with heparin in the immediate postoperative period while the factor IX concentrate was being administered. Oral anticoagulation with acenocoumarol (Acitrom) was started, maintaining the international normalized ratio between 1.5 and 2. He was doing well at follow-up 9 months later.
Thankachen
Roy
R
Department of Thoracic and Cardiovascular Surgery, Christian Medical College and Hospital, Vellore 632 004, India.
George
Biju
B
Shukla
Vinayak
V
Korula
Roy J
RJ
D000074:Acenocoumarol / Q000627:therapeutic use; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery*; D003029:Coagulants / Q000008:administration & dosage*; D005164:Factor IX / Q000008:administration & dosage*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation; D002836:Hemophilia B / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D011474:Prosthesis Design; D012214:Rheumatic Heart Disease / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome
D000925:Anticoagulants; D003029:Coagulants; D005164:Factor IX; D006493:Heparin; D000074:Acenocoumarol