Orally administrated Lactobacillus gasseri TMC0356 and Lactobacillus GG alleviated nasal blockage of guinea pig with allergic rhinitis.
Lactobacillus GG (LGG) and L. gasseri TMC0356 (TMC0356) were investigated for their ability to alleviate nasal blockage associated with allergic rhinitis using a guinea pig model. The increases in sRaw at 10 min and 5 hr after the exposure of the nasal mucosa to OVA were significantly alleviated in the guinea pigs orally administrated with LGG and TMC0356 compared with those of the control (P<0.05 and P<0.01). The total numbers of leukocytes, particularly eosinophils and neutrophils from the nasal cavity lavage fluid, and the OVA-specific IgE concentration in the serum were also decreased in the guinea pigs orally administrated with LGG and TMC0356, although the decreases were not statistically significant. These results suggest that LGG and TMC0356 can alleviate antigen-induced nasal blockage in earlyphase and late-phase inflammatory responses associated with allergic rhinitis.
Technical Research Laboratory, Takanashi Milk Products Co., Ltd., Yokohama, Japan.
Manabu
M
Kawase
Fang
F
He
Akira
A
Kubota
Gaku
G
Harata
Masaru
M
Hiramatsu
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis; D007155:Immunologic Factors / Q000494:pharmacology*; D007778:Lactobacillus / Q000378:metabolism / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D015508:Nasal Obstruction / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000276:immunology / Q000628:therapy*
D007155:Immunologic Factors; D007073:Immunoglobulin E