Stereoselective synthesis of 1'-functionalized-4'-thionucleosides.
Stereoselective functionalization of the 1'-position of 4'-thionucleosides was achieved using a stereoselective S(N)2 reaction controlled by 5-membered ring coordination.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Gunaga
Prashantha
P
Kim
Hea Ok
HO
Tosh
Dilip K
DK
Lee
Hyuk Woo
HW
Choe
Seung Ah
SA
Moon
Hyung Ryong
HR
Gao
Zhan-Guo
ZG
Jacobson
Kenneth A
KA
Chun
Moon Woo
MW
D058918:Adenosine A3 Receptor Antagonists; D015195:Drug Design; D006801:Humans; D006860:Hydrogen Bonding; D013237:Stereoisomerism; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D058918:Adenosine A3 Receptor Antagonists; D013872:Thionucleosides