Thermodynamic studies on PNA and PNA/DNA dendrimer formation.
In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing.
Dipartimento di Scienze Biologiche sez. Biostrutture, Università degli Studi di Napoli Federico II, Napoli, Italy.
Maria
M
Moccia
Domenica
D
Musumeci
Margherita
M
Valente
Giovanni N
GN
Roviello
Roberto
R
Sapio
Carlo
C
Pedone
Enrico M
EM
Bucci
D020029:Base Pairing; D001483:Base Sequence; D003432:Cross-Linking Reagents; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D005782:Gels; D007700:Kinetics; D008968:Molecular Conformation / Q000528:radiation effects; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D010777:Photochemistry; D013816:Thermodynamics; D014466:Ultraviolet Rays
D003432:Cross-Linking Reagents; D050091:Dendrimers; D005782:Gels; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA