[The role of the magnetic resonance in diagnosis of multiple myeloma].
Multiple myeloma comprises syndromes and specific laboratory findings associated with monoclonal proliferation of plasmocytes usually secreting monoclonal protein, ultimately leading to the bone destruction. One of the main diagnostic methods is conventional X-ray of the skeleton. Assessment of bone destruction is mandatory to order a patient to Salmon and Durie clinical staging system. Magnetic resonance (MR), especially sequences surveying the whole skeleton, is the most precise diagnostic tool in imaging of bone marrow and pathologies within. It is a more sensitive, specific and safer method than conventional radiography, which is particularly suitable for detection of secondary osteolytic changes Pattern and intensity of infiltrations in MR is an independent prognostic factor and has been implemented in the modernized clinical staging of multiple myeloma. Similarily, resolution of infiltration in MR due to the treatment is considered as independent prognostic factor. Due to its multiple advantages MR should be a settled diagnostic standard in multiple myeloma.
Katedra i Klinika Hematologii i Chorób Rozrostowych Układu Krwiotwórczego, Poznań. dytfeld@poczta.onet.pl
Dominik
D
Dytfeld
Piotr
P
Sosnowski
Anna
A
Czyz
Mieczysław
M
Komarnick
D001847:Bone Diseases / Q000175:diagnosis* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D010014:Osteolysis / Q000175:diagnosis / Q000209:etiology; D011379:Prognosis; D012680:Sensitivity and Specificity; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000473:pathology
D003287:Contrast Media; D019786:Gadolinium DTPA