Antiasthmic effect of fermented Artemisia princeps in asthmic mice induced by ovalbumin.
Artemisia princeps Pampanini (AP) was fermented with Bifidobacterium infantis K-525 and its antiasthmic effect investigated. AP and fermented AP (FAP) reduced the IgE level in the blood of ovalbumin-induced asthmic mice. Moreover, FAP reduced the IgE, proinflammatory cytokine IL-6, and IL-4 levels in the trachea, as well as in the lung of the experimental asthmic mice, whereas AP only reduced the IgE and IL-6 levels in the lungs. Nonetheless, AP and FAP both inhibited the mRNA expression of IL-6 and TNF-alpha in IgE-induced RBL-2H3 cells. The in vivo antiasthmic effect of FAP was more potent than that of AP. Therefore, these findings suggest that the enhanced antiasthmic effect of AP after bifidus fermentation was possibly due to the regulation of the proinflammatory cytokine biosynthesis of IL-6 and TNF-alpha.
Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Korea.
Eun-Ah
EA
Bae
Sung-Won
SW
Min
Bomi
B
Lee
Nam-Jae
NJ
Kim
Nam-In
NI
Baek
Eun-Joo
EJ
Han
Hae-Gon
HG
Chung
Dong-Hyun
DH
Kim
D000818:Animals; D018926:Anti-Allergic Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D019306:Artemisia / Q000737:chemistry* / Q000378:metabolism; D001249:Asthma / Q000188:drug therapy*; D001644:Bifidobacterium / Q000378:metabolism*; D005285:Fermentation; D006967:Hypersensitivity / Q000517:prevention & control; D007073:Immunoglobulin E; D015847:Interleukin-4; D015850:Interleukin-6; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010047:Ovalbumin / Q000097:blood / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D018926:Anti-Allergic Agents; D015850:Interleukin-6; D010936:Plant Extracts; D012333:RNA, Messenger; D015847:Interleukin-4; D007073:Immunoglobulin E; D010047:Ovalbumin