A patient with hyperglycaemia and normal HbA Ic due to impaired glycation.
A diabetic Caucasian woman presented with discrepantly low HbA Ic values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (I6alpha2 lys --> glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin alpha/beta glycation ratios, as measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66).
Diekman
M J M
MJ
Department of Internal Medicine, Deventer Hospital, Deventer, the Netherlands. m.j.m.diekman@dz.nl
Salden
H J M
HJ
DeVries
J H
JH
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D013058:Mass Spectrometry
D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced