Synthesis of anthraquinone oligonucleotides for triplex stabilization.
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.
School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom.
Zhengyun
Z
Zhao
Guomei
G
Peng
Jan
J
Michels
Keith R
KR
Fox
Tom
T
Brown
D000880:Anthraquinones / Q000737:chemistry*; D001483:Base Sequence; D015195:Drug Design; D004355:Drug Stability; D005453:Fluorescence; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
D000880:Anthraquinones; D009838:Oligodeoxyribonucleotides