Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer.
Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, understanding the events involved in mammary gland development make it possible to recognize those events that, when altered, contribute to breast neoplasia. In this review we focus on lobular carcinomas, discussing the pathology, development, and progression of premalignant lobular lesions from a genomic point of view. We highlight studies utilizing genomic approaches and describe how these investigations have furthered our understanding of the complexity of premalignant breast lesions.
Mastracci
Teresa L
TL
Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, West 10th Ave, Vancouver, BC, Canada V5Z 1L3. tmastracci@bccrc.ca
Boulos
Fouad I
FI
Andrulis
Irene L
IL
Lam
Wan L
WL
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D002278:Carcinoma in Situ / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000473:pathology; D018275:Carcinoma, Lobular / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D005260:Female; D042822:Genomic Instability; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D019656:Loss of Heterozygosity; D042361:Mammary Glands, Human / Q000254:growth & development / Q000473:pathology*; D009024:Morphogenesis; D020411:Oligonucleotide Array Sequence Analysis; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology