The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China.
The frequency of lactase persistence varies widely in human populations. Study showed that the T allele of a C/T transition 13910bp upstream from exon 1 of lactase gene (LCT) was completely associated with lactase persistence in a Finnish population. To evaluate if the frequency of -13910T allele was in concordance with the lactase persistence in northern Chinese populations, in this study, we used Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) to detect the lactase -13910T allelic frequency in 5 northern Chinese populations for the first time. Results showed that the T allele frequency was low in these populations and that it did not match the lactase persistence phenotype in these populations. Therefore the -13910T allelic frequency can not serve as a predictor of the lactase persistence in these populations and this suggests the existence of other possible mechanisms of lactose tolerance in Chinese populations.
Sun
Hai-Ming
HM
Laboratory of Medical Genetics, Harbin Medical University, PR, China.
Qiao
Yuan-Dong
YD
Chen
Feng
F
Xu
Li-Dan
LD
Bai
Jing
J
Fu
Song-Bin
SB
D001483:Base Sequence; D002681:China; D005784:Gene Amplification; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D043322:Lactase / Q000235:genetics*; D007787:Lactose Intolerance / Q000235:genetics*; D008969:Molecular Sequence Data; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D043322:Lactase