Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms.
Cervical cancer is the second most common female cancer worldwide with high risk Human Papillomavirus (HPV) infection playing an essential aetiological role. Oestrogen interacts with HPV at a cellular level causing cell growth and inhibition of apoptosis. Indole derivatives, formed during digestion of cruciferous vegetables, have been shown to have chemopreventative properties inhibiting HPV transcription and influencing oestrogen metabolism. This review describes the interactions between HPV, oestrogen and indole derivatives. Further clinical research is required to evaluate the chemopreventative properties of these agents.
Department of Obstetrics and Gynaecology, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, UK. g.rieck@doctors.net.uk
Gudrun C
GC
Rieck
Alison N
AN
Fiander
D052685:Alphapapillomavirus; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D030361:Papillomavirus Infections; D002583:Uterine Cervical Neoplasms / Q000382:microbiology* / Q000517:prevention & control*; D014675:Vegetables / Q000737:chemistry
D016588:Anticarcinogenic Agents; D007211:Indoles