Naltrexone effect on physiological and subjective response to a cold pressor task.
In this double-blind, cross-over study physiological (i.e. blood pressure, heart rate, plasma catecholamine concentrations, plasma cortisol concentrations) and subjective (i.e. McGill Pain Questionnaire, positive affect, distress) response to a cold pressor task was assessed in 19 subjects 1 h after the administration of 50 mg naltrexone and after placebo. Significant differences in plasma catecholamine concentrations were found. Plasma epinephrine concentrations increased during the 1 h period after naltrexone administration but remained largely unchanged after placebo administration. A significant treatment x period effect was also found for plasma norepinephrine concentrations. No significant differences were found for other measures assessed. Further research is necessary to determine the subpopulations in which these effects are of greatest magnitude and the long term safety implications of these effects.
Kotlyar
Michael
M
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Twin Cities, 7-170 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN 55455, United States. kotly001@umn.edu
al'Absi
Mustafa
M
Brauer
Lisa H
LH
Grant
Jon E
JE
Fong
Erine
E
Kim
Suck Won
SW
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D003080:Cold Temperature; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004723:Endorphins / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D010147:Pain Measurement / Q000187:drug effects
D002395:Catecholamines; D004723:Endorphins; D009292:Narcotic Antagonists; D009271:Naltrexone; D006854:Hydrocortisone; D009638:Norepinephrine