Development of a new photocrosslinkable biodegradable bioadhesive.
Adhesives provide a needle-free method of wound closure and do not require local anaesthetics. Polymeric adhesives have been used for about 3 decades for joining several tissues of the organism. Also, they can accomplish other tasks, such as haemostasis and the ability to seal air leakages and have the potential to serve as delivery systems. PCL was modified with 2-isocyanatoethylmethacrylate to form a macromer that was crosslinked via UV irradiation using Irgacure 2959 by CIBA as the photoinitiating agent. The characterization of the materials was accomplished by: attenuated total reflectance-Fourier transform infrared (ATR-FTIR), swelling capacity determination, evaluation of adhesive capacity (by reaction with aminated substrates) and determination of surface energy by contact angle measurement. Thermal characterization of the adhesive was performed by dynamical mechanical thermal analysis (DMTA) and thermogravimetric analysis (TGA). The morphology of PCL networks was observed using scanning electron microscopy (SEM) both after crosslinking process and following biodegradation in human plasma. The haemocompatibility of the membranes was also evaluated by thrombosis and haemolysis tests.
Department of Chemical Engineering, University of Coimbra, Rua Sílvio Lima, Polo II, 3030-790 Coimbra, Portugal. pcnferreira@gmail.com
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D000268:Adhesiveness; D000818:Animals; D001672:Biocompatible Materials; D001711:Biotransformation; D001777:Blood Coagulation / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D017953:Isocyanates / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D008855:Microscopy, Electron, Scanning; D010777:Photochemistry; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000528:radiation effects; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry; D013997:Time Factors; D014014:Tissue Adhesives / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
C499598:2-hydroxy-1-(4-(hydroxyethoxy)phenyl)-2-methyl-1-propanone; D001672:Biocompatible Materials; D017953:Isocyanates; D008689:Methacrylates; D011091:Polyesters; D014014:Tissue Adhesives; D014867:Water; C016240:polycaprolactone; C029845:2-isocyanatoethyl methacrylate; D011407:Propane