Risks of subarachnoid hemorrhage in siblings: a nationwide epidemiological study from Sweden.
This nationwide study aimed to enhance available data by determining sibling risks of subarachnoid hemorrhage in a total population. The MigMed database at the Karolinska Institute, Stockholm, was used to identify all cases of subarachnoid hemorrhage diagnosed in Sweden between 1987 and 2001. Incidence ratios standardized for age, region, and socioeconomic status (SIRs) were calculated for persons with at least 1 sibling with subarachnoid hemorrhage. The reference group consisted of persons whose siblings had no subarachnoid hemorrhage. A total of 90 affected siblings were identified; their SIR of subarachnoid hemorrhage was 2.75. The risk decreased with increasing age in both men and women. Within the limits of the sample size, no sex differences could be observed. The relatively high sibling risks are likely to be due to heritable causes and shared environmental factors. Genetic causes possibly weigh more in early- than late-onset cases. This study shows the feasibility of carrying out nationwide family studies on subarachnoid hemorrhage.
Center for Family and Community Medicine, Karolinska Institutet, Huddinge, Sweden. jan.sundquist@ki.se
Jan
J
Sundquist
Xinjun
X
Li
Kristina
K
Sundquist
Kari
K
Hemminki
D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D035781:Siblings; D012931:Social Environment; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology* / Q000235:genetics* / Q000401:mortality; D016019:Survival Analysis; D013548:Sweden