The synthesis of C-3β functionalized indoles via a hydroboration/Suzuki-Miyaura coupling sequence.
A method for the functionalization of C-3β of vinyl indoles is described. The procedure involves a hydroboration, followed by a Suxuki-Miyaura cross-coupling with the intermediate alkyl borane. Triflates, bromides, and iodides are suitable coupling partners, allowing access to a variety of elaborated indole compounds.
The Arnold and Mabel Beckman Laboratory for Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Eric M
EM
Ferreira
Brian M
BM
Stoltz