[Corticosteroids effect on angiogenesis in heart muscle].
The process of angiogenesis in a heart muscle is a way of providing the ischaemic myocardium with oxygen and nutritive ingredients. This natural process called therapeutic angiogenesis has been tried in the treatment of patients with coronary artery disease mainly. It has been seen as a chance of an effective beneficial therapy particularly in these patients for whom pharmacological treatment is not sufficient and who are disqualified for operative methods such as the percutaneous coronary angioplasty, or coronary bypass transplantation. The goal of therapeutic angiogenesis is to stimulate the growth of new capillaries in a heart and, as a result, to improve the perfusion and function of a heart muscle. The positive impact of the angiogenesis in a heart muscle is impeded in patients using corticosteroids in treatment for other illnesses. Corticosteroids inhibit the angiogenesis process on a cellular and tissue level. They decrease gene expression for VEGF, iNOS, inhibit the activity of transcriptive factors for AP-1 and NF(k)B. Corticosteroids cause the degradation of a pericellular matrix, inhibit the migration of macrophages and inhibit the synthesis of NO and interleukin. These activities of corticosteroids decrease the number of new vessels in a ischaemic myocardium and, consequently, worsen vascularization and progressive hypoxia.
Slaski Uniwersytet Medyczny w Katowicach, Katedra i Zakład Medycyny i Epidemiologii Srodowiskowej, Zabrze. jjosko@slam.katowice.pl
Jadwiga
J
Jośko
Katarzyna
K
Ratman
Rajmund M
RM
Ratman
D015870:Gene Expression / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D032342:Muscle Cells / Q000187:drug effects*; D016328:NF-kappa B / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D005938:Glucocorticoids; D016328:NF-kappa B; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II