Ring enlargement of cyclic acetals and ketals: a way to seven-membered nucleoside phostones.
Novel seven-membered nucleoside phostones were prepared by the reaction of chlorodiethyl phosphite with 3',5'-acetals or ketals derived from xylo-dT. A mechanism for the ring enlargement was proposed, and support for it was provided by ab initio calculations.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Ondrej
O
Páv
Ivan
I
Barvík
Milos
M
Budesínský
Milena
M
Masojídková
Ivan
I
Rosenberg
D000080:Acetals / Q000737:chemistry*; D003500:Cyclization; D009705:Nucleosides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D000080:Acetals; D009705:Nucleosides; D009943:Organophosphorus Compounds