Pulmonary lymphomatoid granulomatosis in a dog: evidence of immunophenotypic diversity and relationship to human pulmonary lymphomatoid granulomatosis and pulmonary Hodgkin's disease.
We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg-like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.
Park
H-M
HM
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Kwangjin-Ku, Seoul, Korea.
Hwang
D-N
DN
Kang
B-T
BT
Jung
D-I
DI
Song
G-S
GS
Lee
S-J
SJ
Yhee
J-Y
JY
Yu
C-H
CH
Doster
A R
AR
Sur
J-H
JH
D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*