Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion.
Pseudomonas aeruginosa antibiotic resistance has led to the search of natural compounds, which would competitively block its fucose>fructose/mannose-binding lectin (PA-IIL) that mediates its biofilm formation and adhesion to animal cells. Such compounds were found in human milk (HM) and avian egg whites. The present research has revealed that honey and royal jelly (RJ), which are assigned to protect beehive progeny and are applied for human infection therapy, match HM in PA-IIL blocking. The function of their fructose (higher in honey) and mannosylated glycoproteins (higher in RJ) as powerful decoys in PA-IIL neutralization is of ecological/biological importance and implementability for the antibacterial adhesion therapeutic strategy.
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Batia
B
Lerrer
Keren D
KD
Zinger-Yosovich
Benjamin
B
Avrahami
Nechama
N
Gilboa-Garber
D018829:Adhesins, Bacterial / Q000378:metabolism*; D001422:Bacterial Adhesion / Q000187:drug effects*; D002240:Carbohydrate Sequence; D003208:Concanavalin A / Q000378:metabolism; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006722:Honey; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D037121:Plant Lectins / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000099219:Royal Jelly
D018829:Adhesins, Bacterial; D003208:Concanavalin A; D005227:Fatty Acids; D037102:Lectins; D037121:Plant Lectins; D000099219:Royal Jelly; C036850:Ulex europaeus lectins; C038692:adhesin, Pseudomonas