Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives.
A series of novel alkylamino and 9-anilinothiazolo[5,4-b]quinolines were synthesized as potential antitumoral agents. The in vitro cytotoxicity of these compounds was evaluated on several cell lines. The inclusion of electron-withdrawn/acceptor hydrogen-bond groups at position 3' of the anilino ring and the presence of an alkylamino chain on the tricyclic framework (regardless of its position) seem to be structural features relevant to cytotoxic activity.
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, México 04510, Mexico.
Marco A
MA
Loza-Mejía
Karina
K
Maldonado-Hernández
Fernando
F
Rodríguez-Hernández
Rogelio
R
Rodríguez-Sotres
Ignacio
I
González-Sánchez
Angelina
A
Quintero
José D
JD
Solano
Alfonso
A
Lira-Rocha
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000235:genetics*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry*
D011804:Quinolines; D013844:Thiazoles; D004247:DNA