Diabetic muscle infarction: a poorly understood, rare complication of long-standing diabetes mellitus.
Diabetic muscle infarction (DMI) is a rare complication of long-standing diabetes. It does have a fairly characteristic clinical presentation and appearance on magnetic resonance imaging. Despite several hypotheses, the etiology of DMI has not been convincingly determined. A patient with DMI is presented in this report. Analysis of his muscle biopsy suggests impaired nitric oxide formation. We postulate that because nitric oxide is protective against ischemia and/or reperfusion injury in cardiac muscle, insufficient production in skeletal muscle could also predispose to the development of DMI.
Department of Neurology, University of Kentucky Chandler Medical Center, Kentucky Clinic (Wing D), Lexington 40536-0284, USA.
Dominic
D
Fee
Andrew
A
Waclawik
D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology*; D006801:Humans; D007238:Infarction / Q000209:etiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology*; D009569:Nitric Oxide / Q000502:physiology; D013997:Time Factors
D009569:Nitric Oxide