Macrophage infiltration, lectin-like oxidized-LDL receptor-1, and monocyte chemoattractant protein-1 are reduced by chronic HMG-CoA reductase inhibition.
Statin reduces cerebrovascular events independent of its cholesterol lowering effect. We hypothesized that statin inhibits early atherosclerotic change in common carotid artery (CCA), and investigated its effect on lectin-like oxidized-LDL receptor-1 (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) expression, both of which are early atherosclerotic markers. Stroke-prone spontaneous hypertensive rats (SHR-SP) of 8 weeks old were orally treated with vehicle or simvastatin (20mg/kg) daily. After 4 weeks of simvastatin or vehicle treatment, or 2 weeks of vehicle and 2 weeks of simvastatin treatment, CCA was removed. LOX-1 and MCP-1 expression as well as macrophage infiltration were histologically investigated. Lipid deposition was also investigated by Sudan III staining. Simvastatin groups showed significantly smaller amount of lipid deposition and LOX-1 and MCP-1 expression, independent of serum lipid levels. Macrophage infiltration was also decreased. Reduction of cerebrovascular events by statins may be brought by the direct inhibition of atherosclerotic change.
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Japan. a-t1@cc.okayama-u.ac.jp
Atsushi
A
Tsuchiya
Shoko
S
Nagotani
Takeshi
T
Hayashi
Kentaro
K
Deguchi
Yoshihide
Y
Sehara
Toru
T
Yamashita
HanZhe
H
Zhang
Violeta
V
Lukic
Tatsushi
T
Kamiya
Koji
K
Abe
D000818:Animals; D050197:Atherosclerosis / Q000473:pathology / Q000517:prevention & control; D017536:Carotid Artery, Common / Q000378:metabolism; D018932:Chemokine CCL2 / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology; D003864:Depression, Chemical; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007150:Immunohistochemistry; D007958:Leukocyte Count; D008055:Lipids; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D019821:Simvastatin / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D018932:Chemokine CCL2; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin