Genetic association with rheumatoid arthritis-Genetic Analysis Workshop 15: summary of contributions from Group 2.
The papers in presentation group 2 of Genetic Analysis Workshop 15 (GAW15) conducted association analyses of rheumatoid arthritis data. The analyses were carried out primarily in the data provided by the North American Rheumatoid Arthritis Consortium (NARAC). One group conducted analyses in the data provided by the Canadian Rheumatoid Arthritis Genetics Study (CRAGS). Analysis strategies included genome-wide scans, the examination of candidate genes, and investigations of a region of interest on chromosome 18q21. Most authors employed relatively new methods, proposed extensions of existing methods, or introduced completely novel methods for aspects of association analysis. There were several common observations; a group of papers using a variety of methods found stronger association, on chromosomes 6 and 18 and in candidate gene PTPN22 among women with early onset. Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses.
Wilcox
Marsha A
MA
i3 Drug Safety, 950 Winter Street, Waltham, MA 02451, USA. Marsha.Wilcox@i3DrugSafety.com
Li
Zhong
Z
Tapper
Will
W
Browning
Sharon
S
Curtin
Karen
K
Ding
Jie
J
Ding
Yuejing
Y
Gagnon
France
F
He
Qimei
Q
Kuo
Tai-Yue
TY
Li
Mingyao
M
Matthew
George
G
Mei
Ling
L
Rao
Shaoqi
S
Shaw
Jim
J
Wei
Zhi
Z
Yu
Zhaoxia
Z
Zhang
Weihua
W
Zheng
Tian
T
Zhu
Guohua
G
D000465:Algorithms; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D010641:Phenotype; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22