[Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease].
OBJECTIVE
To investigate effects of polymorphic variants of surfactant protein C gene (SFTPC) on the course of the disease in patients with chronic obstructive pulmonary disease (COPD).


METHODS
Sixty COPD patients were examined with COPD of stage 0-IV. The following parameters were studied: smoking index (SI), bronchial patency, lung pathology by the findings of high resolution computed tomography, polymorphisms of SFTPC gene by the data of polymerase chain reaction (PCR) followed by mass-spectrometric detection. A trend was found to correlation between a polymorphic variant of A138C and COPD severity (p = 0.056). A CC genotype occurred more frequently in patients with COPD stages III and IV. A significant correlation exists between a polymorphic variant of A186G and the disease course severity (p = 0.23). Genotypes AA or AG are more typical for patients with COPD stage 0, I and II; GG genotype--stage III and IV. Genotype CC SFPTC A138C and genotype GG SFTPC A186G are significantly associated with pulmonary emphysema (p = 0.004 and p = 0.01, respectively).


CONCLUSIONS
Polymorphic variants of SFTPC affect COPD course.
O A
OA
Tsvetkova
M V
MV
Veselovskaia
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000235:genetics*; D011656:Pulmonary Emphysema / Q000453:epidemiology; D037721:Pulmonary Surfactant-Associated Protein C / Q000235:genetics*; D012720:Severity of Illness Index
D037721:Pulmonary Surfactant-Associated Protein C; C489679:SFTPC protein, human