[Parathyroid and bone. Effect of parathyroid hormone on bone quality].
Intermittent administration of parathyroid hormone (PTH) stimulates bone formation, and continuous infusion of PTH stimulates bone resorption. The preclinical and clinical studies showed that PTH improved bone structure such as trabecular connectivity and cortical thickness, as well as increased bone mass. Its contribution to bone strength is produced by the different mechanism from the anti-resorptive agent. Assessment of bone geometry and site-specific bone change using CT will be required to evaluate its efficacy of anabolic agent on bone quality.
Nagasaki University Hospital, Division of Radiology.
Masako
M
Ito
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000378:metabolism / Q000473:pathology; D010281:Parathyroid Hormone / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D014057:Tomography, X-Ray Computed
D010281:Parathyroid Hormone