Hypercalcemia and high parathyroid hormone-related peptide concentration in a dog with a complex mammary carcinoma.
A 10-year-old female Dachshund was presented with a history of mammary masses, slight lethargy, polyuria, and polydipsia. Physical examination findings included masses involving the first, second, and fourth mammary glands of the left side. The mandibular, axillary, and right popliteal lymph nodes were mildly enlarged. Serum chemistry results included hypercalcemia (13.9 mg/dL, reference interval 8.0-11.5 mg/dL). Although intact parathyroid hormone (PTH) concentration (1.05 pmol/L) was below the reference interval (2-13 pmol/L), PTH-related protein (PTHrP) concentration was markedly increased (9.40 pmol/L, reference value < 2 pmol/L). The masses were surgically removed, and the histopathologic diagnosis was complex mammary carcinoma. Three weeks after surgery, serum total calcium concentration had decreased to 10.5 mg/dL. Resolution of the hypercalcemia and clinical signs supported a diagnosis of humoral hypercalcemia of malignancy associated with mammary gland carcinoma.
Bae
Bo-kyoung
BK
Department of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
Kim
Chae-wook
CW
Choi
Ul-soo
US
Choi
Eun-wha
EW
Jee
Hyang
H
Kim
Dae-yong
DY
Lee
Chang-woo
CW
D000818:Animals; D002277:Carcinoma / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000473:pathology*; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D015674:Mammary Neoplasms, Animal / Q000097:blood / Q000150:complications* / Q000473:pathology; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*
D044162:Parathyroid Hormone-Related Protein