Postpartum seizures after epidural analgesia: a patient with a mutation of the factor V Leiden and prothrombin gene.
We report the case of a 27-year-old parturient who developed a headache within 12 hours of delivery and who subsequently seized. Further examination, including magnetic resonance imaging and computed tomographic scan, showed a partial thrombosis of a transversal venous sinus, the underlying cause being an activated protein C resistance caused by a heterozygote factor V Leiden mutation and heterozygote prothrombin-gene mutation G20210A. Seven months after delivery, the patient is in good health, showing no neurocognitive disability.
van Nordennen
Johannes
J
Department of Anesthesiology, Academic Hospital Flemish Free University of Brussels, 1090, Brussels, Belgium. j.vannordennen@gmail.com
Camu
Frederic
F
D000328:Adult; D015360:Analgesia, Epidural / Q000009:adverse effects*; D016362:Analgesia, Obstetrical / Q000009:adverse effects*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006261:Headache / Q000209:etiology; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D009154:Mutation / Q000235:genetics* / Q000502:physiology*; D049590:Postpartum Period; D011247:Pregnancy; D011486:Protein C / Q000235:genetics / Q000502:physiology; D011516:Prothrombin / Q000235:genetics* / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced* / Q000235:genetics*; D014057:Tomography, X-Ray Computed
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin