Further pterocellins from the New Zealand marine bryozoan Pterocella vesiculosa.
Four new alkaloids, pterocellins C-F (1-4), have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis and comparison of spectroscopic data with that of the known compounds pterocellins A and B. The biological activities of 1-4 were assessed in a number of different assay systems and compared with those of pterocellins A and B.
Department of Chemistry, University of Waikato, Hamilton, New Zealand. michele@waikato.ac.nz
Michèle R
MR
Prinsep
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002013:Bryozoa / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009520:New Zealand; D014249:Trichophyton / Q000187:drug effects
D000470:Alkaloids; D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; C527628:pterocellin D