The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes.
Walter
Eric D
ED
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
Stevens
Daniel J
DJ
Visconte
Micah P
MP
Millhauser
Glenn L
GL
D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D008958:Models, Molecular; D011328:Prions / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism*
D002352:Carrier Proteins; D011328:Prions; C023548:copper-binding protein; D003300:Copper; D015032:Zinc