[Quality evaluation of magnesium oxide tablets using acid neutralization test and dissolution test].
For the purpose of quality evaluation of commercially available magnesium oxide (MgO) tablets, we studied their acid neutralization and dissolution behaviors. The dissolution test was carried out by the paddle method in 1st fluid (pH 1.2). The dissolution amount of MgO from tablets was determined by chelatometric titration. The medium pH was periodically measured. The neutralization reaction in 750 ml of 1st fluid was markedly different between two kinds of commercial tablets. The pH of medium including Magmit tablet reached 8.9 and the dissolution rate of MgO was 81.1% after 20 min. Contrariwise, the final pH of medium including Maglax tablet was 2.5 and the dissolution rate of MgO was 77.1% after 60 min. These results indicate that the dissolution rate of MgO from tablets should be >81.1% to obtain significant acid neutralization action.
Inoue
Chiaki
C
Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya City 6633-8501, Japan. ykinochi@hyo-med.ac.jp
Kogure
Toshiaki
T
Kamata
Aya
A
Ishihara
Mika
M
Muraoka
Reiko
R
Tatsumi
Akitoshi
A
Tanaka
Kuniyoshi
K
Takeshita
Harunori
H
Hamaguchi
Tsuneo
T
Tagawa
Noriko
N
Kobayashi
Yoshiharu
Y
Kadobayashi
Muneo
M
D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D008277:Magnesium Oxide / Q000032:analysis; D011786:Quality Control; D012995:Solubility; D013607:Tablets; D017186:Titrimetry
D013607:Tablets; D008277:Magnesium Oxide