PKC signaling in oxidative hepatic damage.
Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as "stress sensors". Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial role of PKC as a redox sensitive signaling molecule has been widely accepted.
Nitti
Mariapaola
M
Department of Experimental Medicine, General Pathology Section, L.B. Alberti 2, 16132 Genoa, Italy.
Pronzato
Maria A
MA
Marinari
Umberto M
UM
Domenicotti
Cinzia
C
D000818:Animals; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D011493:Protein Kinase C