[The some risk factors for atherosclerosis in men with coronary artery disease depending on the age].
The aim of this study was to search to the factors favouring the earlier revealing of a coronary artery disease by comparing selected immunological, hormonal and biochemical parameters between two groups--younger and older men with coronary artery disease and with responding control groups.


METHODS
In the study were included 93 men--60 with stable angina, confirmed by coronarography (at least 6 months after CABG, PTCA or myocardial infraction, with EF > 40%) and 33 men without atherosclerotic changes in the coronary vessels, as the control group. The two groups were divided depending on age: the younger subgroups [under 60-ty years old--group A with CAD (n=30) and B without CAD (n=18)] and the older subgroup [over 70-ty years old group C with CAD (n=30) and D without CAD (n=15)].


RESULTS
Significantly lower concentration were noted for TNF-alpha--in control groups--by about 50% in the younger and 23% in the older group (r = 0.49) and homocysteine (by about 20% and 22% respectively, r = 0.40). Patients with CAD had higher concentration of CRP then in the control groups (by 52% and 54%, r = 0.28). Weak but positive correlation with the presence of a coronary heart disease was show for IgE and anti-gliadin antibodies (r = 0. 22-0.29).


CONCLUSIONS
The younger and older men with CAD statistically significantly differed in concentration of TNF-alpha and homocysteine.
Stasiakowska-Badura
Elwira
E
Central Clinical Hospital of Ministry of Interior and Administration, Warsaw, Poland. jolanta.seroczynska@CSKMSWIA.pl
Kochmański
Marek
M
D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism; D011859:Radiography; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D011486:Protein C; D014409:Tumor Necrosis Factor-alpha; D006710:Homocysteine