Plasmin and matrix metalloproteinase system in deep venous thrombosis resolution.
Deep venous thrombosis (DVT) is a common event in hospitalized medical and surgical patients. Outside of anticoagulation, few good options exist for decreasing the vein wall damage that results after natural thrombolysis. DVT resolution is complex and involves chemokines, leukocytes, and native vein wall cells. Herein some aspects of DVT resolution related to the intersection of inflammation, the plasminogen and matrix metalloproteinase systems, and their respective inhibitors are reviewed. Ultimately, better knowledge of these natural thrombolytic systems may allow local, directed, and specific acceleration of DVT resolution and decreased vein wall damage.
Henke
Peter K
PK
Section of Vascular Surgery, Jobst Vascualr Research Laboratory, University of Michigan, Ann Arbor, MI 48109-0329, USA. henke@umich.edu
D005341:Fibrinolysin / Q000502:physiology*; D005342:Fibrinolysis; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology*; D010960:Plasminogen Activators / Q000502:physiology; D020246:Venous Thrombosis / Q000503:physiopathology*
D010960:Plasminogen Activators; D005341:Fibrinolysin; D020782:Matrix Metalloproteinases