Association of elevated C-reactive protein levels with an impaired prognosis in patients with surgically treated endometrial cancer.
OBJECTIVE
To evaluate whether C-reactive protein (CRP) serum levels are associated with prognosis in surgically treated endometrial cancer.


METHODS
In the present multicenter study, CRP serum levels were measured preoperatively in 403 surgically staged patients with endometrioid endometrial cancer. Results were correlated to clinical data.


RESULTS
The mean (standard deviation) serum CRP level in patients with endometrial cancer was 1.0 (1.8) mg/dL. Serum CRP levels were associated with tumor stage (P=.01), but not with tumor grade (P=.8), lymph node involvement (P=.8), and age at diagnosis (P=.9). In a univariable survival analysis, serum CRP levels, tumor stage, tumor grade, and age at diagnosis were associated with disease-free and overall survival (all P <.001). In a multivariable Cox regression model, serum CRP levels (P=.001, P=.004), tumor stage (P <.001, P <.001), tumor grade (P=.02, P=.009), and age at diagnosis (P=.002, P=.001) were independent prognostic factors for disease-free and overall survival.


CONCLUSIONS
Our results suggest that elevated serum CRP levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer.


METHODS
II.
Department of Obstetrics, Medical University of Vienna, Vienna, Austria.
Maximilian
M
Schmid
Alois
A
Schneitter
Stefan
S
Hinterberger
Julia
J
Seeber
Alexander
A
Reinthaller
Lukas
L
Hefler
D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies
D015415:Biomarkers; D002097:C-Reactive Protein