Short-term glucocorticoid intake combined with intense training on performance and hormonal responses.
OBJECTIVE
To investigate the effects of short-term prednisolone ingestion combined with intense training on exercise performance, hormonal (adrenocorticotrophic hormone (ACTH), prolactin, luteinising hormone (LH), growth hormone (GH), thyroid-stimulating hormone (TSH), dehydroepiandrosterone (DHEA), testosterone, insulin) and metabolic parameters (blood glucose, lactate, bicarbonate, pH).


METHODS
Eight male recreational athletes completed four cycling trials at 70-75% peak O(2) consumption until exhaustion just before (1) and after (2) either oral placebo or prednisolone (60 mg/day for 1 week) treatment coupled with standardised physical training (2 hours/day), according to a double-blind and randomised protocol. Blood samples were collected at rest, during exercise and passive recovery for the hormonal and metabolic determinations.


RESULTS
Time of cycling was not significantly changed after placebo but significantly increased (p<0.05) after prednisolone administration (50.4 (6.2) min for placebo 1, 64.0 (9.1) min for placebo 2, 56.1 (9.1) min for prednisolone 1 and 107.0 (20.7) min for prednisolone 2). There was no significant difference in any measured parameters after the week of training with placebo but a decrease in ACTH, DHEA, PRL, GH, TSH and testosterone was seen with prednisolone treatment during the experiment (p<0.05). No significant change in basal, exercise or recovery LH, insulin, lactate, pH or bicarbonate was found between the two treatment, but blood glucose was significantly higher under prednisolone (p<0.05) at all time points.


CONCLUSIONS
Short-term glucocorticoid administration induced a marked improvement in endurance performance. Further studies are needed to determine whether these results obtained in recreational male athletes maintaining a rigorous training schedule are gender-dependent and applicable to elite athletes.
Collomp
K
K
Laboratoire Activité Physique, Santé et Performance, UFR STAPS, Université d'Orléans, Orleans, France. katia.collomp@univ-orleans.fr
Arlettaz
A
A
Portier
H
H
Lecoq
A-M
AM
Le Panse
B
B
Rieth
N
N
De Ceaurriz
J
J
D054874:Athletic Performance / Q000502:physiology*; D001642:Bicycling / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005938:Glucocorticoids / Q000494:pharmacology*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D011239:Prednisolone / Q000494:pharmacology*; D013997:Time Factors; D055815:Young Adult
D001786:Blood Glucose; D005938:Glucocorticoids; D006728:Hormones; D011239:Prednisolone