Cross-bridged macrocyclic chelators for stable complexation of copper radionuclides for PET imaging.
Copper-64 (t(1/2)=12.7 h; beta+: 17.4%; E(beta+max)=656 keV; beta-: 39%; E(beta-max)=573 keV) has emerged as an important non-standard positron-emitting radionuclide for positron emission tomography imaging of diseased tissues. A significant challenge of working with copper radionuclides is that they must be delivered to the living system as a stable complex that is attached to a biological targeting molecule for effective imaging and therapy. Significant research has been devoted to the development of ligands that can stably chelate (64)Cu, in particular, the cross-bridged (CB) macrocyclic chelators. This review describes the coordination chemistry and biological behavior of (64)Cu-labeled CB complexes.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. andersoncj@wustl.edu
C J
CJ
Anderson
T J
TJ
Wadas
E H
EH
Wong
G R
GR
Weisman
D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D047028:Macrocyclic Compounds / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry
D002614:Chelating Agents; D003432:Cross-Linking Reagents; D047028:Macrocyclic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D003300:Copper