Strong inhibition of cholera toxin binding by galactose dendrimers.
Galactose-containing dendrimers with long spacer arms inhibit cholera toxin binding as strongly as the natural ganglioside GM1 oligosaccharide does.
Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Hilbert M
HM
Branderhorst
Rob M J
RM
Liskamp
Gerben M
GM
Visser
Roland J
RJ
Pieters
D002772:Cholera Toxin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D050091:Dendrimers / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D012997:Solvents
D050091:Dendrimers; D012997:Solvents; D002772:Cholera Toxin; D005690:Galactose