Diabetic muscle infarction: a poorly understood, rare complication of long-standing diabetes mellitus.
Diabetic muscle infarction (DMI) is a rare complication of long-standing diabetes. It does have a fairly characteristic clinical presentation and appearance on magnetic resonance imaging. Despite several hypotheses, the etiology of DMI has not been convincingly determined. A patient with DMI is presented in this report. Analysis of his muscle biopsy suggests impaired nitric oxide formation. We postulate that because nitric oxide is protective against ischemia and/or reperfusion injury in cardiac muscle, insufficient production in skeletal muscle could also predispose to the development of DMI.
Fee
Dominic
D
Department of Neurology, University of Kentucky Chandler Medical Center, Kentucky Clinic (Wing D), Lexington 40536-0284, USA.
Waclawik
Andrew
A
D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology*; D006801:Humans; D007238:Infarction / Q000209:etiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology*; D009569:Nitric Oxide / Q000502:physiology; D013997:Time Factors
D009569:Nitric Oxide