Adenovirus-associated acute respiratory disease in healthy adolescents and adults: a literature review.
Adenovirus-associated acute respiratory disease (AARD) is well documented in the U.S. military, but little information is readily available on its occurrence in other healthy populations that might also benefit from adenovirus vaccines. We reviewed publications on AARD in non-U.S. military,immunocompetent, young adults in group-living settings. Since adenovirus disease can be severe in immunocompromised and pediatric patients, we also considered AARD in healthcare workers. We evaluated 83 publications, published between 1950 and 2005, concerning 22 countries. Most described outbreaks in foreign military recruits and were published before 1970. More recent reports documented outbreaks in student dormitories and medical facilities. The 83 reports did not provide evidence for AARD being a serious, persistent, contemporary concern in the populations studied, nor did they identify strong interest in adenovirus vaccines. Currently availability, sensitive, molecular diagnostic tests may better define the importance of AARD in populations outside the U.S. military.
Sivan
Anjali V
AV
U.S. Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010-5403, USA.
Lee
Terrence
T
Binn
Leonard N
LN
Gaydos
Joel C
JC
D000208:Acute Disease; D000256:Adenoviridae; D000258:Adenovirus Infections, Human / Q000150:complications*; D000293:Adolescent; D000328:Adult; D005260:Female; D014943:Global Health; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008887:Military Medicine; D008889:Military Personnel; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000209:etiology; D014481:United States / Q000453:epidemiology