The heterotrimeric [corrected] G protein subunit G alpha i is present on mitochondria.
Receptors that signal through heterotrimeric [corrected] GTP binding (G) proteins mediate the majority of intercellular communication. Recent evidence suggests that receptors acting through G proteins also transfer signals across the nuclear membrane. Here we present cell fractionation and immunolabeling data showing that the heterotrimeric [corrected] G protein subunit Galphai is associated with mitochondria. This finding suggests that G protein receptor signaling may be a feature common to all membranes.
Lyssand
John S
JS
Department of Pharmacology, University of Washington Seattle, Box 357750, WA, USA.
Bajjalieh
Sandra M
SM
D015415:Biomarkers / Q000378:metabolism; D002460:Cell Line; D005591:Chemical Fractionation; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism*; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018272:Porins / Q000378:metabolism
D015415:Biomarkers; D018272:Porins; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D043802:GTP-Binding Protein alpha Subunits, Gq-G11