Comprehensive assessment of P21 polymorphisms and lung cancer risk.
The purpose of this study is to comprehensively evaluate potential functional polymorphisms in the P21 gene in relation to the risk of lung cancer. We first determined the frequencies of P21 polymorphisms in 27 healthy Koreans, and then examined three polymorphisms (-2266G > A, S31R, and IVS2 + 16G > C), based on their frequencies and haplotype-tagging status, in a case-control study. Individuals with at least one -2266A allele were at a significantly decreased risk of lung cancer compared with those harboring the -2266 GG genotype [adjusted odds ratio (OR) = 0.71, 95% confidence interval (CI) = 0.53-0.95, P = 0.02). The haplotypes (ht2-4) carrying 31R or IVS2 + 16C alleles were associated with a significantly decreased risk of lung cancer compared with the haplotype 31S/IVS2 + 16G, which carried wild-type alleles at both loci (adjusted OR = 0.65, 95% CI = 0.50-0.83, P = 0.007)]. When the -2266A allele and ht2-4 were considered to be protective alleles, the risk of lung cancer decreased in a dose-dependent manner as the number of protective alleles increased (P = 0.0002). These results suggest that a combined analysis of these three P21 polymorphisms might better predict the risk of lung cancer than the analysis of a single polymorphism.
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Yi Young
YY
Choi
Cancer Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea.
Hyo-Kyung
HK
Kang
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jin Eun
JE
Choi
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jin Sung
JS
Jang
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Eun Jin
EJ
Kim
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Sung Ick
SI
Cha
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Won Kee
WK
Lee
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sin
S
Kam
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Chang Ho
CH
Kim
Department of Internal Medicine, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Sung Beom
SB
Han
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea.
Tae Hoon
TH
Jung
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. jaeyong@kyungpook.ac.kr.|Cancer Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea. jaeyong@kyungpook.ac.kr.|Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, Korea. jaeyong@kyungpook.ac.kr.
Jae Yong
JY
Park
D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21