A computational model for telomere-dependent cell-replicative aging.
Telomere shortening provides a molecular basis for the Hayflick limit. Recent data suggest that telomere shortening also influence mitotic rate. We propose a stochastic growth model of this phenomena, assuming that cell division in each time interval is a random process which probability decreases linearly with telomere shortening. Computer simulations of the proposed stochastic telomere-regulated model provides good approximation of the qualitative growth of cultured human mesenchymal stem cells.
Hematology Service, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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RD
Portugal
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MG
Land
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BF
Svaiter
D049109:Cell Proliferation; D016922:Cellular Senescence / Q000235:genetics*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D016615:Telomere / Q000235:genetics* / Q000378:metabolism