Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus.
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.
The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2030, La Jolla, CA 92037, USA.
Peter J
PJ
Gaskill
Michelle
M
Zandonatti
Tim
T
Gilmartin
Steven R
SR
Head
Howard S
HS
Fox
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D002478:Cells, Cultured; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology*; D008358:Mannose / Q000032:analysis; D015302:Simian Immunodeficiency Virus / Q000737:chemistry / Q000472:pathogenicity*; D014771:Virion / Q000737:chemistry*; D014774:Virulence
D008358:Mannose