Trends in thyroid cancer demographics and surgical therapy in the United States.
BACKGROUND
The incidence of thyroid cancer is increasing. Our objective was to characterize the demographic pattern of this increase and to examine trends in surgical therapy for thyroid cancer.


METHODS
Analysis of the SEER and NHDS databases was performed from 1974 to 2000 and from 1979 to 2004, respectively. Thyroid-related diagnoses were extracted, and thyroid cancer (ICD 193.X) were analyzed using the SAS statistical package. We compared the population-adjusted incidence of thyroid cancer and examined regional variations in the operative therapy for thyroid cancer.


RESULTS
The incidence of thyroid cancer has increased during the past 26 years. This increase occurred predominantly in women and in the Northeastern and Southern United States, whereas there has been a decrease in thyroid cancers in the Midwest. Papillary cancer accounts for most of this increase. Total thyroidectomy (TT) is now the most common operation for thyroid cancer. No differences in the use of TT were observed based on hospital size or insurance status.


CONCLUSIONS
The increasing incidence of thyroid cancer in the United States is predominantly in women. These results suggest that women are a high-risk group for developing thyroid cancer although men have higher stage disease.
Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9156, USA.
Ian
I
Mitchell
Edward H
EH
Livingston
Alice Y
AY
Chang
Shelby
S
Holt
William H
WH
Snyder
Ildiko
I
Lingvay
Fiemu E
FE
Nwariaku
D044383:Black People / Q000706:statistics & numerical data; D002291:Carcinoma, Papillary / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007348:Insurance, Health / Q000706:statistics & numerical data; D008297:Male; D018426:SEER Program; D017678:Sex Distribution; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000601:surgery*; D013965:Thyroidectomy / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American