Ni-catalyzed mild arylation of alpha-halocarbonyl compounds with arylboronic acids.
A simple yet powerful Ni catalyst can be used to promote direct arylations of alpha-halocarbonyl compounds, including a range of esters, amides, and ketones, with various arylboronic acids under mild conditions. The method tolerates beta-hydrogens and functional groups in the substrates and offers reactivity and selectivity profiles that are complementary to those found in the well-established Buchwald-Hartwig approach.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Chao
C
Liu
Chuan
C
He
Wei
W
Shi
Mao
M
Chen
Aiwen
A
Lei