The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents.
Cross-sectional and longitudinal volumetric studies suggest that the corpus callosum (CC) continues to mature structurally from infancy to adulthood. Diffusion tensor imaging (DTI) provides in vivo information about the directional organization of white matter microstructure and shows potential for elucidating even more subtle brain changes during adolescent development. We used DTI to examine CC microstructure in healthy right-handed adolescents (n=92, ages 9-24 years) and correlated the imaging data with motor task performance. The primary DTI variable was fractional anisotropy (FA), which reflects the degree of white matter's directional organization. Participants completed an alternating finger tapping test to assess interhemispheric transfer and motor speed. Task performance was significantly correlated with age. Analyses of variance indicated that 9- to 11-year-olds generally performed worse than each of the older groups. Males outperformed females. Significant positive correlations between age and FA were observed in the splenium of the CC, which interconnects posterior cortical regions. Analyses of variance indicated that individuals older than 18 years had significantly higher FA than 9- to 11-year-olds. FA levels in the genu and splenium correlated significantly with task performance. Regression analyses indicated that bimanual coordination was significantly predicted by age, gender, and splenium FA. Decreases in alternating finger tapping time and increases in FA likely reflect increased myelination in the CC and more efficient neuronal signal transmission. These findings expand upon existing neuroimaging reports of CC development by showing associations between bimanual coordination and white matter microstructural organization in an adolescent sample.
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA. muet0005@umn.edu
Ryan L
RL
Muetzel
Paul F
PF
Collins
Bryon A
BA
Mueller
Ann
A
M Schissel
Kelvin O
KO
Lim
Monica
M
Luciana
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D002648:Child; D015331:Cohort Studies; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005385:Fingers / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D012044:Regression Analysis; D012727:Sex Characteristics