Association of diarrhoea in childhood with blood pressure and coronary heart disease in older age: analyses of two UK cohort studies.
BACKGROUND
There is a suggestion that acute dehydration in childhood may lead to elevated blood pressure. We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration, were related to measured blood pressure and coronary heart disease in older adults.


METHODS
Data were pooled from two prospective UK cohort studies (participants born 1920-39) in which episodes of diarrhoea were ascertained from health visitor records from birth until 5 years of age. Blood pressure and coronary heart disease were assessed during medical examination in men and women over 64 years of age. In total, 5203 men and women had data on diarrhoea in early life, adult blood pressure and a range of covariates; 4181 of these also had data on coronary heart disease status.


RESULTS
The prevalence of diarrhoea in infancy (3.3%) and between 1 and 5 years (1.1%) was low. There was no relation of diarrhoea from either period (age- and sex-adjusted results for diarrhoea in infancy presented here) with measured blood pressure [coefficient for systolic; 95% CI (confidence interval): 0.44; -2.88-3.76] or coronary heart disease (Odds ratio, OR; 95% CI: 0.91; 0.54-1.54) in adulthood. There was a similar lack of association when hypertension was the outcome of interest. These observations were unchanged after adjustment for a range of covariates.


CONCLUSIONS
In the largest study to date to examine the relation, there was no evidence that diarrhoea in early life had an influence on measured blood pressure, hypertension or coronary heart disease in older adults.
Batty
G David
GD
MRC Social & Public Health Sciences Unit, University of Glasgow, Glasgow, UK. david-b@msoc.mrc.gla.ac.uk
Smith
George Davey
GD
Fall
Caroline H D
CH
Sayer
Avan Aihie
AA
Dennison
Elaine
E
Cooper
Cyrus
C
Gale
Catharine R
CR
D000368:Aged; D002648:Child; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000209:etiology*; D003681:Dehydration / Q000150:complications; D003967:Diarrhea / Q000150:complications*; D004739:England; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D016014:Linear Models; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors