CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier.
A 60-year-old man was diagnosed with asymptomatic T-cell granular lymphocyte (T-LGL) leukemia in September 2006. He was serologically positive for human T-cell leukemia virus type 1 (HTLV-1). However, monoclonal integration of the HTLV-1 genome was not detected in the peripheral blood, suggesting that HTLV-1 did not contribute to the pathogenesis of T-LGL leukemia in the present case. Phenotypically, neoplastic cells of our case were CD3+, CD4*, CD8+, CD16-, CD56+, CD57*, and T-cell receptor (TCR) alphabeta+. They also coexpressed CD20 antigen with weak intensity. This represented a unique case of T-LGL leukemia showing a typical clinical and phenotypic features.
Nakano-Akamatsu
Sonoko
S
Department of Hematology, Omihachiman Community Medical Center, Omihachiman Shiga 523-0082, Japan. naoaki-akamatsu@nifty.com
Takahashi
Ryoichi
R
Sekioka
Yukiko
Y
Hosokawa
Yohei
Y
Inaba
Tohru
T
D018951:Antigens, CD20 / Q000378:metabolism*; D019002:CD56 Antigen / Q000378:metabolism*; D005434:Flow Cytometry; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000378:metabolism
D018951:Antigens, CD20; D019002:CD56 Antigen; D016693:Receptors, Antigen, T-Cell, alpha-beta