Metachromins R--T, new sesquiterpenoids from marine sponge Spongia sp.
Three new sesquiterpenoids, metachromins R--T (1--3), have been isolated from an Okinawan marine sponge Spongia sp. The structures and stereochemistry of 1--3 were elucidated on the basis of the spectroscopic data. Metachromins S (2) and T (3) showed modest cytotoxicity.
Graduate School of Pharmaceutical Sciences, Hokkaido University, sapporo 060-0812, Japan.
Yohei
Y
Takahashi
Mika
M
Yamada
Takaaki
T
Kubota
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C526055:metachromin R; C526056:metachromin S; C526057:metachromin T