MRI-guided radiofrequency ablation of breast cancer: preliminary clinical experience.
This study was designed to demonstrate the feasibility of MRI-guided radiofrequency ablation (RFA) of breast cancer. A total of three women diagnosed with invasive ductal breast cancer were treated with percutaneous MRI-guided RFA, according to a treat and resect protocol, in our hospital. RFA procedures were performed in an open 0.5T Signa-SP imager allowing direct patient access and real-time monitoring of the procedure. In all patients ablation was performed with a 15-gauge insulated MRI-compatible multiple needle probe. MRI thermometry and contrast-enhanced postablation MRI were used to evaluate the ablation process. Patients underwent lumpectomy within a week of the RFA procedure. Histopathology confirmed successful (100%) tumor ablation in one patient, and partial tumor destruction (33% and 50%, respectively) in two patients. Challenges of MRI-guided breast RFA that need to be solved to facilitate progress of the technique toward clinical practice are discussed.
van den Bosch
Maurice
M
Department of Radiology, Stanford University Medical Center, Stanford, California, USA. mbosch@standord.edu
Daniel
Bruce
B
Rieke
Viola
V
Butts-Pauly
Kim
K
Kermit
Eben
E
Jeffrey
Stefanie
S
D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009361:Neoplasm Invasiveness / Q000473:pathology; D016896:Treatment Outcome