Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses.
Dedifferentiated liposarcoma of the pleura is an extremely rare malignancy mimicking a variety of tumors, such as other sarcomas, mesothelioma, and malignant solitary fibrous tumor of the pleura. Liposarcoma of the pleura can be combined with mediastinal involvement, and in most cases it may be impossible to be certain where the primary tumor originated. In this report, we describe a very rare occurence of a dedifferentiated liposarcoma of the pleura in a 76-year-old woman associated with a distinct second dedifferentiated liposarcoma of the mediastinum. Histologically, the pleural tumor demonstrated spindle cells arranged in a fascicular pattern, whereas the mediastinal tumor was mostly adipocytic with small areas of spindle cells. Vimentin and protein S100 were focally expressed by the tumor cells. The differential diagnosis of the pleural mass included malignant solitary fibrous tumor. Cytogenetic analysis showed supernumerary ring chromosomes in the pleural tumor, as well as strong amplification of MDM2 and CDK4 genes in both tumors. Array comparative genomic hybridization showed amplifications of chromosome arms 6q, 12q, and 15q, shared by both tumors and strongly pointing to a common origin.
Laboratory of Clinical and Experimental Pathology, 30 avenue de la voie romaine, Louis Pasteur Hospital, 06002, Nice, France.
Maxime
M
Benchetritt
Véronique
V
Hofman
Nicolas
N
Vénissac
Caroline
C
Brennetot
Antoine
A
Italiano
Alain
A
Aurias
Bernard
B
Padovani
Florence
F
Pedeutour
Paul
P
Hofman
D000368:Aged; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D005784:Gene Amplification; D006801:Humans; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000175:diagnosis; D010997:Pleural Neoplasms / Q000235:genetics* / Q000473:pathology*; D054363:Solitary Fibrous Tumor, Pleural / Q000473:pathology; D014057:Tomography, X-Ray Computed