[Toxic or drug-induced granulomatous reactions].
OBJECTIVE
To review the current concepts in toxic and drug-induced granulomatous reactions.


BACKGROUND
Granulomatous reactions are induced by various chemical agents, treatments or foreign bodies. According to the breaking way into the organism, the lungs, the liver, the kidneys or the skin are mainly concerned, but systemic granulomatosis mimicking sarcoidosis is possible. Therefore systematic analysis of environmental, occupational and leisure exposures and quest for medical or illicit drugs is mandatory to identify the responsible agent. Over the recent period, chronic beryllium disease, interferon-alpha therapy, BCG immunotherapy and allopurinol have been more frequently involved.


CONCLUSIONS
Literature review uncovers a variety of potential toxic exposures and highlights the necessity of a clear sighted research to identify them.
Service de médecine interne, centre hospitalier Lyon-Sud, université de Lyon, Pierre-Bénite cedex, France. denis.vital-durand@chu-lyon.fr
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Vital Durand
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D000493:Allopurinol / Q000009:adverse effects; D000963:Antimetabolites / Q000009:adverse effects; D001500:BCG Vaccine / Q000009:adverse effects; D001607:Berylliosis / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury; D006099:Granuloma / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects; D016898:Interferon-alpha / Q000009:adverse effects; D007674:Kidney Diseases / Q000139:chemically induced; D008171:Lung Diseases / Q000139:chemically induced; D012507:Sarcoidosis / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced
D000963:Antimetabolites; D001500:BCG Vaccine; D007155:Immunologic Factors; D016898:Interferon-alpha; D000493:Allopurinol