Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.
A new dihydropyranone, ( R)-6-[( S)-2-hydroxy-4-(4-hydroxyphenyl)butyl]-5,6-dihydropyran-2-one ( 1), was isolated from Tapinanthus dodoneifolius. The structure was determined from spectroscopic and X-ray crystallographic analysis. Compound 1 (named dodoneine) showed a relaxing effect on preconstricted rat aortic rings (IC 50 of 81.4 +/- 0.9 microM).
Ouedraogo
Maurice
M
Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS/UMR 6187, 40 Avenue du Recteur Pineau, F-86022, Poitiers Cedex, France.
Carreyre
Hélène
H
Vandebrouck
Clarisse
C
Bescond
Jocelyn
J
Raymond
Guy
G
Guissou
Innocent-Pierre
IP
Cognard
Christian
C
Becq
Frédéric
F
Potreau
Daniel
D
Cousson
Alain
A
Marrot
Jérôme
J
Coustard
Jean-Marie
JM
D000354:Africa, Western; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D018360:Crystallography, X-Ray; D028183:Loranthaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
C527017:( R)-6-(( S)-2-hydroxy-4-(4-hydroxyphenyl)butyl)-5,6-dihydropyran-2-one; D011753:Pyrones