Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary study).
OBJECTIVE
to determine the correlation between free thyroid hormone level and left ventricular ejection fraction in newly diagnosed Graves' patients.


METHODS
this is a preliminary study with an initial cross-sectional design using free thyroxine level as a parameter of thyroid hormone state and left ventricular ejection fraction (LVEF) as a parameter of left ventricular systolic function. Free thyroxine level was measured in the laboratory and the LVEF was assessed by Simpson's methods of echocardiography study.


RESULTS
ten patients (7 men and 3 women; age 18-52 years old) were studied. Their average of fT4 was 5.75 (SD 0.96) ng/dL and their average of LVEF was 70.57 (SD 4.50)%. There was positive correlation coefficient between free thyroxine level and left ventricular ejection fraction (r=0.711, p=0.021) in newly diagnosed Graves' patients.


CONCLUSIONS
in this study strong positive correlation was found between free thyroxine (fT4) and left ventricular ejection fraction (LVEF) in newly diagnosed Graves' patients.
Department of Internal Medicine, Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Arif
A
Mansjoer
Idrus
I
Alwi
Imam
I
Subekti
Yoga Iwanoff
YI
Kasjmir
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D013599:Systole; D013974:Thyroxine / Q000097:blood*; D014463:Ultrasonography; D016277:Ventricular Function, Left
D013974:Thyroxine