Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy.
This paper explores the potential of isotope V/Q lung scans to quantify lung disease. Areas of restricted perfusion in subjects with a pulmonary embolus (PE) were identified in 3D reconstructions of V/Q images achieved using anatomical data from the Visible Human Project. From these, the extent of lung damage was quantified. Significant differences in the values of both LogSD V and LogSD Q (p > 0.05) obtained from plots of V and Q against Log(V/Q) were found between normal subjects and subjects with a PE, but no correlation was found between either of these parameters and the degree of lung damage in subjects with a PE (p > 0.05). Whilst V/Q values were log normally distributed, the V/Q distributions from the subjects with a PE failed to show the bimodal distribution predicted from theoretical considerations and MIGET measurements previously reported. There was a statistically significant difference in the mean and standard deviation values of the V/Q distributions between normal subject and subjects with a PE (p < 0.05) but not in the median values (p > 0.05). There was no correlation between the mean, median and standard deviation of the distributions from the subjects with a PE and the percentage of damage present (p > 0.05).
Brook
B S
BS
School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Murphy
C M
CM
Breen
D
D
Miles
A W
AW
Tilley
D G
DG
Wilson
A J
AJ
D003627:Data Interpretation, Statistical; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011655:Pulmonary Embolism / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012123:Pulmonary Ventilation; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012119:Respiration; D012680:Sensitivity and Specificity; D016008:Statistical Distributions; D017556:Technetium Compounds / Q000493:pharmacokinetics; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*
D019275:Radiopharmaceuticals; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin