Disseminated intravascular coagulation and a negative D-dimer test.
The diagnosis of disseminated intravascular coagulation (DIC) requires the presence of a fibrin-related marker. D-dimer is frequently used in clinical practice as a fibrin-related marker. We present a case of paraneoplastic DIC with a false-negative D-dimer test. Repeating the test using a different D-dimer assay as well as the measurement of other fibrinolysis markers confirmed the diagnosis of DIC.
Department of Internal Medicine, Albert Schweitzer Hospital, Location Dordwijk, PO Box 444, 3300 AK Dordrecht, the Netherlands. a.constantinescu@asz.nl
A A
AA
Constantinescu
P B
PB
Berendes
M-D
MD
Levin
D000368:Aged; D001681:Biological Assay; D015415:Biomarkers; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000503:physiopathology; D005337:Fibrin; D005338:Fibrin Fibrinogen Degradation Products; D006801:Humans; D008297:Male
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005337:Fibrin