How noisy and replicable are DNA microarry data?
This paper analyses variability in highly replicated measurements of DNA microarray data conducted on nylon filters and Affymetrix GeneChips with different cDNA targets, filters, and imaging technology. Replicability is assessed quantitatively using correlation analysis as a global measure and differential expression analysis and ANOVA at the level of individual genes.
Sundaresh
Suman
S
Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA. suman@uci.edu
Hung
She-pin
SP
Hatfield
G Wesley
GW
Baldi
Pierre
P
D016477:Artifacts; D001709:Biotechnology / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D015342:DNA Probes; D018076:DNA, Complementary / Q000378:metabolism; D005189:False Positive Reactions; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016366:Open Reading Frames; D015203:Reproducibility of Results; D012984:Software
D015342:DNA Probes; D018076:DNA, Complementary