The decarboxylative Blaise reaction.
Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided beta-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride.
Chemical Development Division, LG Life Sciences, Ltd./R&D, 104-1 Moonji-dong, Yusong-gu, Daejeon 305-380, Korea.
Jae Hoon
JH
Lee
Bo Seung
BS
Choi
Jay Hyok
JH
Chang
Hee Bong
HB
Lee
Joo-Yong
JY
Yoon
Jaeick
J
Lee
Hyunik
H
Shin
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D003653:Decarboxylation; D008314:Malonates / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
D000179:Acrylates; D002712:Chlorides; D008314:Malonates; D009570:Nitriles; D012997:Solvents; D017967:Zinc Compounds; C016837:zinc chloride; D011188:Potassium