Posttranscriptional control of neuronal development by microRNA networks.
The proper development of the nervous system requires precise spatial and temporal control of gene expression at both the transcriptional and translational levels. In different experimental model systems, microRNAs (miRNAs) - a class of small, endogenous, noncoding RNAs that control the translation and stability of many mRNAs - are emerging as important regulators of various aspects of neuronal development. Further dissection of the in vivo physiological functions of individual miRNAs promises to offer novel mechanistic insights into the gene regulatory networks that ensure the precise assembly of a functional nervous system.
Gladstone Institute of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, 1650 Owens Street, San Francisco, CA 94158, USA. fgao@gladstone.ucsf.edu
Fen-Biao
FB
Gao
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000502:physiology; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D043244:Ribonuclease III / Q000235:genetics / Q000502:physiology
D051860:Fragile X Messenger Ribonucleoprotein 1; D035683:MicroRNAs; D043244:Ribonuclease III