Compartmental relaxation and diffusion tensor imaging measurements in vivo in lambda-carrageenan-induced edema in rat skeletal muscle.
Integrated diffusion tensor T(2) measurements were made on normal and edematous rat muscle, and the data were fitted with one- and two-compartment models, respectively. Edematous muscle exhibited a short-lived component (T(2) = 28 +/- 6 ms), with diffusion characteristics similar to that of normal muscle, and a long-lived component (T(2) = 96 +/- 27 ms), with greater mean apparent diffusion coefficient (ADC) and lower fractional anisotropy (FA). With this two-component description of diffusion and relaxation, values of ADC and FA estimated with a conventional pulsed-gradient spin-echo sequence will depend on the echo time, relative fraction of short-lived and long-lived water signals, and the intrinsic ADC and FA values within the tissue. On the basis of the relative differences in water diffusion properties between long-lived and short-lived water signals, as well as the similarities between the short-lived component and normal tissue, it is postulated that these two signal components largely reflect intracellular and extracellular water.
Fan
Reuben H
RH
Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232-2310, USA.
Does
Mark D
MD
D000818:Animals; D002351:Carrageenan; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002351:Carrageenan