Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis.
Three new Securinega alkaloids, secu'amamines B-D ( 1- 3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues ( 4, 6- 9). The structures 1- 3 were elucidated by spectroscopic methods including 2D NMR, and all eight compounds were evaluated for cytotoxicity against two cancer cell lines.
Ohsaki
Ayumi
A
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan. a-ohsaki.fm@tmd.ac.jp
Kobayashi
Yukino
Y
Yoneda
Kaisuke
K
Kishida
Akio
A
Ishiyama
Haruaki
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006572:Heterocyclic Compounds, Bridged-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D051379:Mice; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006572:Heterocyclic Compounds, Bridged-Ring; C527014:secu'amamine B; C527015:secu'amamine C; C527016:secu'amamine D