[Indinavir-associated tubulointerstitial renal disease].
Indinavir, used for the treatment of HIV disease, forms distinctive crystals in the urine. The crystalluria has been associated principally with several urinary tract abnormalities which may require discontinuation of the drug. We present a case of progressive leucocyturia and renal impairment occurring during indinavir treatment which illustrates vividly the impact of the crystalluria on the tubulointerstitial renal compartment.
Département de médecine, centre hospitalier de l'université McGill, Montréal, Canada. raymonde.gagnon@muhc.mcgill.ca
Raymonde F
RF
Gagnon
Amira
A
Mehio
Sameena
S
Iqbal
Christos M
CM
Tsoukas
D000328:Adult; D003460:Crystallization; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000737:chemistry / Q000652:urine; D006801:Humans; D019469:Indinavir / Q000009:adverse effects* / Q000737:chemistry / Q000652:urine; D007962:Leukocytes; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D014556:Urine / Q000737:chemistry / Q000166:cytology
D017320:HIV Protease Inhibitors; D019469:Indinavir