Signaling by committee: receptor clusters determine pathways of cellular activation.
Receptor clustering is a common signaling mechanism for cell surface receptors. Exogenous ligands such as antibodies or synthetic analogues can be used to artificially induce clustering. New studies using defined synthetic ligands suggest that the spatial organization of these clusters attenuates signaling in one pathway but has no effect in another.
Cairo
Christopher W
CW
Department of Chemistry, Alberta Ingenuity Centre for Carbohydrate Science, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. ccairo@ualberta.ca
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008024:Ligands; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D051966:Phospholipase C gamma / Q000378:metabolism; D010766:Phosphorylation; D017455:Receptors, IgE / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D017455:Receptors, IgE; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma; D002118:Calcium