Hypoglycemic activity of Ailanthus excelsa leaves in normal and streptozotocin-induced diabetic rats.
The hypoglycemic activity of a 70% methanol extract from the leaves of Ailanthus excelsa Roxb. (Simaroubaceae) was studied in normal, transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. Oral administration of the extract at doses of 14, 70 and 350 mg/kg body weight caused no significant changes in fasting blood glucose levels of normal rats. In an oral glucose tolerance test, the extract produced a significant decrease in glycemia 90 min after the glucose pulse. Daily administration of A. excelsa extract for 60 days produced a significant hypoglycemic effect in diabetic animals. In addition, this treatment improved the altered renal function observed in diabetic control rats. This study suggests that Ailanthus leaf extract could be potentially useful for post-prandial hyperglycemia treatment.
Departamento de Biología del Desarrollo, Instituto Superior de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas y Universidad Nacional de Tucumán, Chacabuco 461, (4000) San Miguel de Tucumán, Argentina.
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Cabrera
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Genta
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Said
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Farag
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Rashed
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Sánchez
D032268:Ailanthus / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D000432:Methanol / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D013453:Sulfonylurea Compounds; C057619:glimepiride; D000432:Methanol