Does red-man reaction stimulate macrophage activation syndrome in children with systemic juvenile idiopathic arthritis?
Macrophage activation syndrome (MAS) is a major cause of death in patients with systemic juvenile idiopathic arthritis (JIA). We describe 4 patients who developed MAS during or after vancomycin treatment. Vancomycin should be used with great care in patients with systemic JIA.
Pediatric Cardiology Unit, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey. solgar@hacettepe.edu.tr
Seref
S
Olgar
Turkan
T
Ertugrul
Omer
O
Devecioglu
Kemal
K
Nisli
Rukiye Eker
RE
Omeroglu
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D013577:Syndrome; D016896:Treatment Outcome; D014640:Vancomycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D014640:Vancomycin