An efficient synthesis of chiral beta-hydroxy sulfones via ru-catalyzed enantioselective hydrogenation in the presence of iodine.
Ru-SUNPHOS catalyzed asymmetric hydrogenation of a variety of sulfonyl ketones (R = alkyl, aryl) in the presence of iodine gave enantioenriched hydroxyl sulfones with good catalytic efficiency. Further investigation revealed that the in situ generated anhydrous HI is the operating additive.
Wan
Xiaobing
X
School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China.
Meng
Qinghua
Q
Zhang
Hongwei
H
Sun
Yanhui
Y
Fan
Weizheng
W
Zhang
Zhaoguo
Z
D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis*
D013450:Sulfones; D006859:Hydrogen; D007455:Iodine