The inflammatory response in cardiac surgery. An up-to-date overview with the emphasis on the role of heat shock proteins (HSPs) 60 and 70.
Cardiac surgical operations are associated with the development of a systemic inflammatory response syndrome (SIRS). In most cases, the inflammatory response is apparent only in its subclinical form. In some cases, however, it can become clinically manifest or even life-threatening. This review article presents some new data regarding its biological importance, along with an insight into the recently discovered role played by heat shock proteins 60 and 70.
Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine, University Hospital in Hradec Králové, Czech Republic. kunes.pavel@fnhk.cz
Pavel
P
Kunes
Vladimír
V
Lonský
Jirí
J
Mand'ák
Miroslav
M
Brtko
Martina
M
Kolácková
Ctirad
C
Andrýs
Manuela
M
Kudlová
Jan
J
Krejsek
D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D018834:Chaperonin 60 / Q000378:metabolism*; D016638:Critical Illness; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D015425:Myocardial Reperfusion; D011183:Postoperative Complications; D013152:Splanchnic Circulation; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins