Eosinophilic esophagitis in children: clinical manifestations.
During the past decade, the increasing number of recognized cases of eosinophilic esophagitis in children and adults has resulted in a dramatic expansion of the medical literature surrounding it. Clinical and basic research has contributed to a better, but still incomplete, body of knowledge regarding its clinical and histologic manifestations, as well as its immunologic and genetic pathogenesis. This article provides a broad framework for recognizing the remarkable variety of clinical manifestations of eosinophilic esophagitis in children, which must be considered as part of the differential diagnosis in many different clinical situations.
Cincinnati Center for Eosinophilic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 2010, Cincinnati, OH 45229, USA. phil.putnam@cchmc.org <phil.putnam@cchmc.org>
Philip E
PE
Putnam
D002648:Child; D002669:Child Welfare; D003680:Deglutition Disorders; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000473:pathology*; D004941:Esophagitis / Q000175:diagnosis* / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology*; D005764:Gastroesophageal Reflux; D006801:Humans; D012307:Risk Factors