The effect of gabapentin and phenytoin on sperm-morphology in Wistar rats.
The objective of the present study was to investigate the effects of the antiepileptic drugs, gabapentin and phenytoin, on sperm morphology in Wistar rats. Groups (n=5) of rats were treated with cyclophosphamide (20 mg/day), gabapentin (16, 25, 32 mg/day) and phenytoin (3.5, 5.5, 7 mg/day) for five consecutive days. 14 and 35 days after the last exposure, sperm morphology was evaluated by standard procedure. Gabapentin and phenytoin did not induce significant changes in sperm morphology. The results suggest that phenytoin and gabapentin are not germ cell mutagens in males, and do not appear to adversely affect male fertility.
Department of Pharmacology, Kasturba Medical College, Manipal University, Light House Hill Road, Mangalore 1, Karnataka, India. shettyakhila@yahoo.com
Akhila J
AJ
Shetty
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D000077206:Gabapentin; D008297:Male; D009153:Mutagens / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D009153:Mutagens; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D000077206:Gabapentin; D003520:Cyclophosphamide