[Role of heat shock proteins in developing of innate immunity reactions].
Increasing interest to heat shock proteins (HSP) from biologists and medics is connected to widespread distribution of HSP in live nature and reflects their key role in support of life functions which is based on the unique polyfunctionality of these biomolecules. Together with main function, which is defense of biologic systems from stress effects, some HSP in the process of evolution acquired the ability to incorporate in the reactions of the immune system. The in vestmen of this protein in practical reactions of innate immunity system are described. Analysis of mechanisms underlying the adjuvant effect of pro- and eukaryotic HSP in innate immunity system is presented. HSP receptor structures on target cells as well as triggered intracellular signaling pathways are described.
P G
PG
Sveshnikov
V V
VV
Malaĭtsev
V I
VI
Kiselev
D000818:Animals; D019013:CD40 Antigens / Q000502:physiology; D005057:Eukaryotic Cells / Q000737:chemistry; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000145:classification / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D011387:Prokaryotic Cells / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000276:immunology; D051116:Receptors, Scavenger / Q000276:immunology / Q000302:isolation & purification; D051193:Toll-Like Receptors / Q000276:immunology
D019013:CD40 Antigens; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D011956:Receptors, Cell Surface; D051116:Receptors, Scavenger; D051193:Toll-Like Receptors