Synthesis, characterization, antioxidant activity and DNA-binding studies of two rare earth(III) complexes with naringenin-2-hydroxy benzoyl hydrazone ligand.
Two novel rare earth complexes, Y(III) complex (1) and Eu(III) complex (2), with naringenin-2-hydroxy benzoyl hydrazone ligand were synthesized and characterized. The interaction of the two metal complexes and the free ligand with calf thymus DNA (CT DNA) was investigated by electronic absorption spectroscopy, fluorescence spectroscopy and viscosity measurement. All the experimental evidences indicate that these three compounds can strongly bind to CT DNA via an intercalation mechanism. The intrinsic binding constants of the Y(III) complex (1), Eu(III) complex (2) and the free ligand with CT DNA were 2.1 x 10(4), 8.5 x 10(4) and 1.6 x 10(4) M(-1), respectively. Furthermore, the antioxidant activity of the metal complexes was determined by hydroxyl radical scavenging method in vitro.
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Tian-Rong
TR
Li
Zheng-Yin
ZY
Yang
Bao-Dui
BD
Wang
Dong-Dong
DD
Qin
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D004247:DNA / Q000235:genetics*; D004583:Electrons; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008674:Metals, Rare Earth; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013053:Spectrophotometry; D014783:Viscosity
D000975:Antioxidants; D044950:Flavanones; D006835:Hydrazones; D008024:Ligands; D008674:Metals, Rare Earth; C532143:naringenin-2-hydroxy benzoyl hydrazone; D017665:Hydroxyl Radical; D004247:DNA