Carboranyl thymidine analogues for neutron capture therapy.
Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
Tjarks
Werner
W
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. tjarks.1@osu.edu
Tiwari
Rohit
R
Byun
Youngjoo
Y
Narayanasamy
Sureshbabu
S
Barth
Rolf F
RF
D000818:Animals; D001895:Boron / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry* / Q000627:therapeutic use*; D004194:Disease; D006801:Humans; D017247:Neutron Capture Therapy; D010770:Phosphotransferases / Q000378:metabolism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*
D001896:Boron Compounds; D010770:Phosphotransferases; D001895:Boron; D013936:Thymidine