Send in the clamps: control of DNA translesion synthesis in eukaryotes.
The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage.
Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Jacob G
JG
Jansen
Maria I
MI
Fousteri
Niels
N
de Wind
D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology / Q000378:metabolism*; D016296:Mutagenesis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D013698:Templates, Genetic; D025801:Ubiquitin / Q000378:metabolism
D018809:Proliferating Cell Nuclear Antigen; D025801:Ubiquitin; D004247:DNA; D004259:DNA-Directed DNA Polymerase