A flavonoid gossypin binds to cyclin-dependent kinase 2.
Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments.
Kim
Hojung
H
Department of Bioscience and Biotechnology, BMIC, 1 Hwayang-dong, Kwangjin-Ku, Konkuk University, Seoul 143-701, Republic of Korea.
Lee
Eunjung
E
Kim
Jihye
J
Jung
Bora
B
Chong
Youhoon
Y
Ahn
Joong-Hoon
JH
Lim
Yoongho
Y
D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism*; D005419:Flavonoids / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship
D005419:Flavonoids; C022944:gossypin; D051357:Cyclin-Dependent Kinase 2