[Comparative study of hemostatic properties of the complex and mixture of high molecular weight heparin and adenosine triphosphate].
Anticoagulant and nonenzymatic fibrinolytic activities increased in blood plasma of 6-7-month-old rats after repeated intramuscular administration of the heparin-adenosine triphosphate complex (G-ATP). The mixture of heparin and ATP had no fibrin depolymerizing activity in vitro. Repeated intramuscular administration of the mixture had anticoagulant effect although it was 1.5-1.6 times less pronounced compared to the complex. A higher anticoagulant and fibrinolytic efficiency of the G-ATP complex compared to the mixture is concluded.
Liapina
L A
LA
Pastorova
V E
VE
Obergan
T Iu
TIu
D000255:Adenosine Triphosphate / Q000008:administration & dosage*; D000818:Animals; D004338:Drug Combinations; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D008297:Male; D051381:Rats
D004338:Drug Combinations; D005343:Fibrinolytic Agents; D000255:Adenosine Triphosphate; D006493:Heparin