New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania.
Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel beta-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.
Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna. Avda. Astrofísico Fco. Sánchez No 2, 38206, La Laguna, Tenerife, Spain.
Paulino
P
Delgado-Méndez
Nora
N
Herrera
Haydee
H
Chávez
Ana
A
Estévez-Braun
Angel G
AG
Ravelo
Fernando
F
Cortes
Santiago
S
Castanys
Francisco
F
Gamarro
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D007891:Leishmania / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D013729:Terpenes