Hairpin mimics with phenanthroline- and bipyridine-derived linkers.
The synthesis and structural stabilities of modified oligonucleotide hairpins containing phenanthroline- and bipyridine-modified loops is reported. Phenanthroline (phen) and bipyridine (bipy) building blocks were synthesized, incorporated into DNA-oligonucleotides, and analyzed by thermal denaturation experiments. The so modified oligomers were found to form stable hairpin structures. Tm values were not affected by divalent transition metals.
Bianké
Gapian
G
Department of Chemistry, Biochemistry, University of Bern, Bern, Switzerland.
Häner
Robert
R
D015082:2,2'-Dipyridyl / Q000737:chemistry; D001483:Base Sequence; D002412:Cations; D015195:Drug Design; D008024:Ligands; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry
D002412:Cations; D008024:Ligands; D009841:Oligonucleotides; D010618:Phenanthrolines; D015082:2,2'-Dipyridyl