Drug-induced hepatitis - morphological and ultrastructural aspects.
Frequency of drug-induced liver diseases is increasingly, more than 200 different drugs being incriminated in hepatic disorders. We performed a retrospective study on 65 cases of deaths due to drug intoxications and an experimental model of subacute hepatitis induced by acetaminophen. In our experimental model, we observed various histological lesions: granular degeneration, vascular congestion, lymphoplasmocyte infiltration, cytonecrosis. Histological criteria are not specifically, but very usefully, because based on these criteria we can suspect a drug etiology in hepatic disorders when any other cause is absent. Ultrastructural study of hepatocytes revealed some modifications, in addition to data provided by optical microscopy.
Medical Emergency Clinic, University of Medicine and Pharmacy of Craiova, Romania. ancaenescus@yahoo.com
Aurelia
A
Enescu
P
P
Mitruţ
Elena
E
Buteică
B
B
Stănoiu
Anca
A
Enescu
D000328:Adult; D002102:Cadaver; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D014617:Vacuoles / Q000473:pathology