Prednisone vs. placebo in withdrawal therapy following medication overuse headache.
This proof-of-concept study evaluated the efficacy of prednisone for the treatment of withdrawal symptoms in patients with medication overuse headache (MOH) in a randomized, placebo-controlled, double-blind design. Twenty patients were randomized and underwent in-patient withdrawal therapy. The total number of hours with severe or moderate headache within the first 72 and 120 h was significantly lower in the prednisone group. The results show that prednisone might be effective in the treatment of medication withdrawal headache.
Pageler
L
L
Department of Neurology, Cologne City Hospitals, Cologne, Germany. pagelerl@kliniken-koeln.de
Katsarava
Z
Z
Diener
H C
HC
Limmroth
V
V
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D051271:Headache Disorders, Secondary / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011241:Prednisone / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D011241:Prednisone