Construction of stereodefined 1,1,2,2-tetrasubstituted cyclopropanes by acid catalyzed reaction of aryldiazoacetates and alpha-substituted acroleins.
Michael-initiated ring closure of aryldiazoacetates and alpha-substituted acroleins under acid catalysis offers a unique opportunity for the stereoselective formation of various tetrasubstituted cyclopropanes.
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan.
Takuya
T
Hashimoto
Yuki
Y
Naganawa
Taichi
T
Kano
Keiji
K
Maruoka
D000085:Acetates / Q000737:chemistry*; D000143:Acids / Q000737:chemistry; D000171:Acrolein / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D003979:Diazonium Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000085:Acetates; D000143:Acids; D003521:Cyclopropanes; D003979:Diazonium Compounds; D000171:Acrolein