Systemic mastocytosis with plasma cell dyscrasia: report of a case.
Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by infiltration of bone marrow and other tissues by neoplastic mast cells. A subset of patients with SM has associated hematologic malignancy usually of myeloid origin and comprises an entity termed systemic mastocytosis with associated clonal hematological non-mast cell lineage disease (SM-AHNMD) by the current WHO classification. Reports of clonal lymphoid malignancies associated with SM are rare. We describe a patient who was simultaneously diagnosed with indolent SM and a plasma cell dyscrasia fitting the definition of monoclonal gammopathy of undetermined significance (MGUS). We also discuss the pathologic interaction between the neoplastic mast cells of SM and the lymphoid/plasma cell malignancy when these two entities coexist.
Pullarkat
Sheeja T
ST
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, United States. spullarkat@mednet.ucla.edu
Sedarat
Franklin
F
Paquette
Ronald
R
Said
Jonathan
J
D000368:Aged; D000369:Aged, 80 and over; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008415:Mastocytosis / Q000473:pathology*; D010265:Paraproteinemias / Q000473:pathology*