Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration.
In the present work, accumulation and distribution of aluminium in the rat brain following both intraperitoneal and oral administration were studied. Electrothermal atomic absorption spectrometry was used to determine aluminium concentration in different brain areas (cerebellum, ventral midbrain, cortex, hippocampus, and striatum). Most of the brain areas showed accumulation of aluminium, but a greater and more significant increase was noted in the group receiving aluminium via intraperitoneal administration. Aluminium distribution was also dependent on the administration route.
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Santiago de Compostela, San Francisco 1, 15782 Santiago de Compostela, Spain.
Sofía
S
Sánchez-Iglesias
Ramón
R
Soto-Otero
Javier
J
Iglesias-González
M Carmen
MC
Barciela-Alonso
Pilar
P
Bermejo-Barrera
Estefanía
E
Méndez-Alvarez
D000284:Administration, Oral; D000535:Aluminum / Q000008:administration & dosage* / Q000032:analysis* / Q000493:pharmacokinetics; D000818:Animals; D001921:Brain / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000535:Aluminum