[Indinavir-associated tubulointerstitial renal disease].
Indinavir, used for the treatment of HIV disease, forms distinctive crystals in the urine. The crystalluria has been associated principally with several urinary tract abnormalities which may require discontinuation of the drug. We present a case of progressive leucocyturia and renal impairment occurring during indinavir treatment which illustrates vividly the impact of the crystalluria on the tubulointerstitial renal compartment.
Gagnon
Raymonde F
RF
Département de médecine, centre hospitalier de l'université McGill, Montréal, Canada. raymonde.gagnon@muhc.mcgill.ca
Mehio
Amira
A
Iqbal
Sameena
S
Tsoukas
Christos M
CM
D000328:Adult; D003460:Crystallization; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000737:chemistry / Q000652:urine; D006801:Humans; D019469:Indinavir / Q000009:adverse effects* / Q000737:chemistry / Q000652:urine; D007962:Leukocytes; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D014556:Urine / Q000737:chemistry / Q000166:cytology
D017320:HIV Protease Inhibitors; D019469:Indinavir