Clip-phen conjugates for the specific cleavage of nucleic acids.
For the first time Clip-Phen (1) was conjugated to oligonucleotides to provide very efficient tools for the cleavage of nucleic acids at specific positions. The synthesis of the conjugates as well as the cleavage experiments are reported.
Laurent
Alain
A
BIOMERIEUX, Molecular Biology Business Unit, Grenoble, France. alain.laurent@eu.biomerieux.com
Wright
Michael
M
Laayoun
Ali
A
Meunier
Bernard
B
Tissot
Ludivine
L
Pitie
Marguerite
M
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000302:isolation & purification; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry*
C115240:Clip-phen; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; D010618:Phenanthrolines; D004247:DNA