[A tumour-mimic pig liver model for guiding focused ultrasound thermal ablation].
There is no established liver tumour model in pigs to study the efficacy of ablative treatment options available for the treatment of liver tumours by physical agents. A tumour-mimic model visible with high contrast on sonograms and on gross pathology has been studied at mid-term on 20 pigs. The aim was to determine if these tumour-mimics are well tolerated and can be used to validate the use of thermal therapies at a preclinical stage. The dimensions of the tumour-mimics measured on sonograms were reproducible (diameter: 9.6 +/- 1.9 mm) and correlated with those performed in gross pathology (R(2)=0.73). The accuracy of focused ultrasound thermal therapy can be evaluated preclinically using these tumour-mimics.
Inserm, U556, Lyon, F-69003, France. melodelima@lyon.inserm.fr
D
D
Melodelima
Wa
W
N'djin
H
H
Parmentier
S
S
Chesnais
M
M
Rivoire
J-Y
JY
Chapelon
D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D004564:Electrocoagulation / Q000379:methods; D005240:Feasibility Studies; D006498:Hepatectomy; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D013552:Swine; D013997:Time Factors; D014464:Ultrasonic Therapy / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods
D003287:Contrast Media