The inflammatory response in cardiac surgery. An up-to-date overview with the emphasis on the role of heat shock proteins (HSPs) 60 and 70.
Cardiac surgical operations are associated with the development of a systemic inflammatory response syndrome (SIRS). In most cases, the inflammatory response is apparent only in its subclinical form. In some cases, however, it can become clinically manifest or even life-threatening. This review article presents some new data regarding its biological importance, along with an insight into the recently discovered role played by heat shock proteins 60 and 70.
Kunes
Pavel
P
Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine, University Hospital in Hradec Králové, Czech Republic. kunes.pavel@fnhk.cz
Lonský
Vladimír
V
Mand'ák
Jirí
J
Brtko
Miroslav
M
Kolácková
Martina
M
Andrýs
Ctirad
C
Kudlová
Manuela
M
Krejsek
Jan
J
D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D018834:Chaperonin 60 / Q000378:metabolism*; D016638:Critical Illness; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D015425:Myocardial Reperfusion; D011183:Postoperative Complications; D013152:Splanchnic Circulation; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins