[Stress concept in the centennial of Hans Selye].
Stress concept substantially evolved since its creation by Hans Selye in 1936. New definitions of the stress were suggested. The knowledge of the stress mechanisms and mediators was widened. The changes in genes activities were included in the list of participants of the stress response along with the hormones, neurotransmitters and tissue factors. "Nonspecificity" of the stress response mechanisms was defined more exactly, especially concerning their neuronal parts. The stress theory was enriched by the idea of "allostasis". Stress concept and the discussions on it stimulated investigation of molecular-genetic mechanisms of the organisms' defensive reactions, and this concept still retain its significance for modem biomedical sciences.
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D052636:Allostasis; D000818:Animals; D001685:Biological Factors / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D049673:History, 20th Century; D006728:Hormones / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D012106:Research; D013312:Stress, Physiological / Q000266:history* / Q000503:physiopathology; D013577:Syndrome
D001685:Biological Factors; D006728:Hormones; D018377:Neurotransmitter Agents