Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora.
Two hundred fifteen compounds isolated from plants of Northeastern Brazil flora have been assayed against epimastigote forms of Trypanosoma cruzi, using the tetrazolium salt MTT as an alternative method. Eight compounds belonging to four different species: Harpalyce brasiliana (Fabaceae), Acnistus arborescens and Physalis angulata (Solanaceae), and Cordia globosa (Boraginaceae) showed significant activity. Among them, a novel and a known pterocarpan, a chalcone, four withasteroids, and a meroterpene benzoquinone were the represented chemical classes.
Vieira
Nashira Campos
NC
Laboratório de Farmacognosia, Universidade de Brasília, Brasília, DF, Brazil.
Espíndola
Laila Salmen
LS
Santana
Jaime Martins
JM
Veras
Maria Leopoldina
ML
Pessoa
Otília Deusdênia Loiola
OD
Pinheiro
Sávio Moita
SM
de Araújo
Renata Mendonça
RM
Lima
Mary Anne Sousa
MA
Silveira
Edilberto Rocha
ER
D000818:Animals; D001773:Blood Cells / Q000469:parasitology; D001938:Brazil; D002478:Cells, Cultured; D002599:Chalcone; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
D036343:Pterocarpans; D014344:Trypanocidal Agents; D002599:Chalcone