Neural mechanisms underlying auditory feedback control of speech.
The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 136 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.
Tourville
Jason A
JA
Department of Cognitive and Neural Systems, Boston University, 677 Beacon St., Boston, MA 02215, USA. jtour@cns.bu.edu
Reilly
Kevin J
KJ
Guenther
Frank H
FH
D000328:Adult; D000465:Algorithms; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003627:Data Interpretation, Statistical; D005246:Feedback / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D015233:Models, Statistical; D010100:Oxygen / Q000097:blood; D013060:Speech / Q000502:physiology*
D010100:Oxygen