Withanolides from Withania somnifera roots.
Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-sitosterol glucoside, stigmasterol glucoside, alpha+beta glucose were isolated from the roots of Withania somnifera. Among the known compounds, Viscosa lactone B, stigmasterol, stigmasterol glucoside and alpha+beta glucose are being reported from the roots of W. somnifera for the first time. One of the new compounds contained the rare 16beta-acetoxy-17(20)-ene the other contained unusual 6alpha-hydroxy-5,7alpha-epoxy functional groups in the withasteroid skeleton. The structures were elucidated by spectroscopic methods and chemical transformations.
Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow 226015, India. laxmisra@hotmail.com
Laxminarain
L
Misra
Priyanka
P
Mishra
Archana
A
Pandey
Rajender S
RS
Sangwan
Neelam S
NS
Sangwan
Rakesh
R
Tuli
D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D032341:Withania / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry* / Q000302:isolation & purification*
D005960:Glucosides; D010936:Plant Extracts; D012855:Sitosterols; D054358:Withanolides; C464587:stigmasterol glucoside; C025473:gamma-sitosterol; D013265:Stigmasterol; C011015:lyoniside