Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods.
Increases in the prevalence of antibiotic resistant bacteria require new approaches for the treatment of infectious bacterial pathogens. It is now clear that a nanotechnology-driven approach using nanoparticles to selectively target and destroy pathogenic bacteria can be successfully implemented. We have explored this approach by using gold nanorods that have been covalently linked to primary antibodies to selectively destroy the pathogenic Gram-negative bacterium, Pseudomonas aeruginosa. We find that, following nanorod attachment to the bacterial cell surface, exposure to near-infrared radiation results in a significant reduction in bacterial cell viability.
Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA.
R Sean
RS
Norman
John W
JW
Stone
Anand
A
Gole
Catherine J
CJ
Murphy
Tara L
TL
Sabo-Attwood
D006046:Gold / Q000737:chemistry*; D008027:Light; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes; D010777:Photochemistry; D011550:Pseudomonas aeruginosa / Q000528:radiation effects*
D006046:Gold