Evaluation of the influences of exercise, birth date, and osteochondrosis on plasma bone marker concentrations in Hanoverian Warmblood foals.
OBJECTIVE
To determine whether plasma concentrations of bone turnover markers in growing Hanoverian foals are influenced by age, housing conditions, or osteochondrosis.


METHODS
165 healthy foals and 119 foals with osteochondrosis.


METHODS
Foals were allocated according to birth date and housing management into groups of early-born (born before March 31, 2001; n = 154 foals, 88 of which were healthy and 66 of which had osteochondrosis) and late-born (born after March 31, 2001; 130 foals, 77 of which were healthy and 53 of which had osteochondrosis) foals. Plasma osteocalcin and carboxyterminal propeptide of type I collagen concentrations were analyzed as markers of bone formation, and carboxyterminal telopeptide of type I collagen concentration was analyzed as a marker of bone resorption. Foals underwent radiographic evaluation to screen for osteochondrosis.


RESULTS
Plasma concentrations of osteocalcin, carboxyterminal propeptide of type I collagen, and carboxyterminal telopeptide of type I collagen decreased with age, but these changes were more distinct in late-born foals than in early-born foals. Neither sex nor predisposition to develop osteochondrosis affected the pattern of bone marker changes in either group.


CONCLUSIONS
An age-related decrease in concentrations of bone markers was seen during the first 200 days of life. Changes in bone marker concentrations were similar for foals with osteochondrosis and healthy foals. The correlation between the decrease in bone marker concentration and date of birth indicates that there are differences in skeletal development between early- and late-born foals.
Vervuert
Ingrid
I
Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, D-30173 Hannover, Germany.
Winkelsett
Sarah
S
Christmann
Ludwig
L
Bruns
Erich
E
Hoppen
Hans-Otto
HO
Distl
Ottmar
O
Hertsch
Bodo
B
Coenen
Manfred
M
D000375:Aging / Q000097:blood*; D000822:Animal Husbandry; D000818:Animals; D015415:Biomarkers; D001846:Bone Development; D024042:Collagen Type I; D005260:Female; D006734:Horse Diseases / Q000097:blood* / Q000378:metabolism; D006736:Horses; D006799:Housing, Animal; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010007:Osteochondritis / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011347:Procollagen / Q000097:blood
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin