[The condition of external respiratory mechanics in patients with type 1 diabetes].
External respiratory mechanics was studied in 141 patients with type 1 diabetes mellitus (DM1) and 36 healthy controls using computed analysis of flow-volume loop and total body plethysmography. The DM1 patients were divided into 4 groups: group 1 consisted of patients without clinical signs of microangiopathic complications; groups 2 and 3 consisted of patients with initial and advanced manifestations of late diabetic syndrome (LDS), respectively; group 4 consisted of patients suffering from severe endocrinopathy with end-stage chronic renal failure. The velocity and volume parameters in groups 1 and 2 did not differ significantly from those in the controls. Significant reduction in the vital capacity, forced expiratory volume in one second, and total lung capacity was noted in patients with advanced LDS and uremia. Forced expiratory volume in one second decreased in proportion to reduction in lung vital capacity, which did not cause Tiffno index to leave the reference range. The authors came to the conclusion that DMI causes restrictive ventilatory defect, associated with advanced clinical manifestations of microangiopathic alterations.
Sokolov
E I
EI
Demidov
Iu I
IuI
Dudaev
V A
VA
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology; D006801:Humans; D008297:Male; D010991:Plethysmography; D015656:Respiratory Mechanics / Q000502:physiology*; D012720:Severity of Illness Index; D014797:Vital Capacity / Q000502:physiology