Anti-coagulant aptamers.
In the past decade development of aptamer technology is poised into several fields with various clinical applications. With this progress, aptamer based anti-coagulant agents are evolved and continuing their applications with clinical trials. At present several anti-coagulant aptamers are available against different proteins from blood coagulation cascade. In this review, the mechanism and functions of anti-coagulant aptamers, as an alternate candidate to other available anti-coagulant agents are discussed.
National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan. gopi-subashchandrabose@aist.go.jp
Subash Chandra Bose
SC
Gopinath
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000991:Antithrombins / Q000494:pharmacology; D052157:Aptamers, Nucleotide / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D005164:Factor IX / Q000037:antagonists & inhibitors; D015942:Factor VIIa / Q000037:antagonists & inhibitors; D006801:Humans; D018046:Protein C Inhibitor / Q000494:pharmacology; D052156:SELEX Aptamer Technique
D000925:Anticoagulants; D000991:Antithrombins; D052157:Aptamers, Nucleotide; D018046:Protein C Inhibitor; D005164:Factor IX; D015942:Factor VIIa