Alternative and improved syntheses of highly potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA.
Improved syntheses of potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA were accomplished from cheap stating material, D-ribose. New synthetic methods were found to be superior to old methods from the viewpoint of use of cheap starting material, number of steps, and overall yields.
Hou
Xiyan
X
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Lee
Hyuk Woo
HW
Tosh
Dilip K
DK
Zhao
Long Xuan
LX
Jeong
Lak Shin
LS
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D058909:Adenosine A3 Receptor Agonists; D015394:Molecular Structure; D012266:Ribose / Q000737:chemistry*; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
C510478:2-chloro-N(6)-(3-iodobenzyl)-5'-N-methylcarbamoyl-4'-thioadenosine; D058909:Adenosine A3 Receptor Agonists; D013872:Thionucleosides; C504222:thio-Cl-IB-MECA; D012266:Ribose; D000241:Adenosine