Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.
Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase.
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Hye-Young
HY
Min
Eun-Jung
EJ
Park
Ji-Young
JY
Hong
You-Jin
YJ
Kang
Sun-Jack
SJ
Kim
Hwa-Jin
HJ
Chung
Eun-Rhan
ER
Woo
Tran Manh
TM
Hung
Ui Jung
UJ
Youn
Yeong Shik
YS
Kim
Sam Sik
SS
Kang
KiHwan
K
Bae
Sang Kook
SK
Lee
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*
D034242:Cyclooctanes; D017705:Lignans; C510994:dibenzocyclooctadiene lignan