Intracellular trafficking of somatostatin receptors.
The somatostatin receptor subtypes 1-5 (sst(1)-sst(5)) exhibit different intracellular trafficking and endosomal sorting after agonist exposure. The internalization of the somatostatin receptor subtypes sst(2), sst(3) and sst(5) occurs to a much higher extent after somatostatin exposure than of sst(1) or sst(4). After endocytosis, sst(2) and sst(5) recycle to the plasma membrane, whereas sst(3) is predominantly down-regulated. This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins.
Institut für Pharmakologie und Toxikologie, Universität Würzburg, Würzburg, Germany.
Stefan
S
Jacobs
Stefan
S
Schulz
D000818:Animals; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D021381:Protein Transport; D017481:Receptors, Somatostatin / Q000378:metabolism*; D015398:Signal Transduction
D017481:Receptors, Somatostatin