In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML.
A
A
Liso
A
A
Bogliolo
V
V
Freschi
M P
MP
Martelli
S A
SA
Pileri
M
M
Santodirocco
N
N
Bolli
M F
MF
Martelli
B
B
Falini
D019295:Computational Biology; D003593:Cytoplasm / Q000378:metabolism; D020440:Gene Duplication; D015894:Genome, Human; D006801:Humans; D007124:Immunoenzyme Techniques; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D009154:Mutation / Q000235:genetics*; D049790:Nuclear Export Signals; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D010446:Peptide Fragments / Q000502:physiology
C000716967:NPM1 protein, human; D049790:Nuclear Export Signals; D009687:Nuclear Proteins; D010446:Peptide Fragments; D000090243:Nucleophosmin