Evolutionary plasticity of developmental gene regulatory network architecture.
Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for embryogenesis in these animals, we discovered an almost perfectly conserved five-gene network subcircuit required for endoderm specification. We show here that the GRN structure upstream and downstream of the conserved network kernel has, by contrast, diverged extensively. Mesoderm specification is accomplished quite differently; the Delta-Notch signaling system is used in radically distinct ways; and various regulatory genes have been coopted to different functions. The conservation of the conserved kernel is thus the more remarkable. The results indicate types of network linkage subject to evolutionary change. An emergent theme is that subcircuit design may be preserved even while the identity of genes performing given roles changes because of alteration in their cis-regulatory control systems.
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Veronica F
VF
Hinman
Eric H
EH
Davidson
D000818:Animals; D004707:Endoderm / Q000254:growth & development; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks / Q000502:physiology*; D008648:Mesoderm / Q000254:growth & development; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D012617:Sea Urchins / Q000235:genetics / Q000254:growth & development*; D015398:Signal Transduction; D013215:Starfish / Q000235:genetics / Q000254:growth & development*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000502:physiology
D051880:Receptors, Notch; D020825:T-Box Domain Proteins