Immunohistochemical studies in a hydroptic fetus with pulmonary lymphangiectasia and trisomy 21.
This case report presents a hydroptic trisomy 21 fetus affected by lymphatic dysplasia with no other malformations. Our studies using CD31, CD34, smooth muscle actin, desmin, and D2-40 antibodies immunohistochemistry confirm the diagnosis of severe pulmonary lymphangiectasia associated with lymphangiectasia ih the mediastinum and small bowel.
Rutigliani
M
M
Department of Pathology (DICMI), University of Genoa, Gaslini Institute, Genova, Italy.
Boccardo
F
F
Campisi
C
C
Bonioli
E
E
Fulcheri
E
E
Bellini
C
C
D000015:Abnormalities, Multiple / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000199:Actins / Q000276:immunology; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34 / Q000276:immunology; D003893:Desmin / Q000276:immunology; D004314:Down Syndrome; D017809:Fatal Outcome; D005260:Female; D005313:Fetal Death; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D008200:Lymphangiectasis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000276:immunology; D011247:Pregnancy
D000199:Actins; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34; D003893:Desmin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C500987:monoclonal antibody D2-40