Epilepsy and mood disorders.
Mood disorders (MD) are a frequent comorbidity of epilepsy with a negative impact on quality of life. The higher prevalence of MD in people with epilepsy (PWE) is most likely a reflection of a bidirectional relation between the two conditions, and common pathogenic mechanisms. Treatment of MD in PWE is safe with selective serotonin reuptake inhibitor (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), but nonpsychiatrists need to know when to refer these patients to a psychiatrist for further evaluation and treatment.
Kanner
Andres M
AM
Department of Neurological Sciences, Rush Medical College, Rush University Medical Center, Chicago, Illinois 60612, USA. akanner@rush.edu
D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D017281:Cost of Illness; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology; D004827:Epilepsy / Q000453:epidemiology* / Q000523:psychology; D017034:Epilepsy, Frontal Lobe / Q000453:epidemiology / Q000523:psychology; D006304:Health Status; D006801:Humans; D019964:Mood Disorders / Q000453:epidemiology* / Q000523:psychology; D011788:Quality of Life