[Parathyroid and bone. Bone metabolism in hypoparathyroidism].
Hypoparathyoidism is classified into two categories: PTH deficient and PTH refractory (i.e. pseudohypoparathyrodism [PHP]). Bone metabolism is different between the two. In PTH deficient hypoparathyroidism such as post-operative hypoparathyroidism, BMD is increased with relatively low bone turnover markers. In PHP, which characterized by PTH resistance in proximal renal tubules, bone response to PTH is sometimes preserved. In some PHP cases, high bone turnover state is observed, which correlates with serum PTH levels.
Okazaki
Ryo
R
Teikyo University Chiba Medical Center, Third Department of Medicine.
D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002864:Chromogranins; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006801:Humans; D007011:Hypoparathyroidism / Q000145:classification / Q000209:etiology / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D009154:Mutation; D010281:Parathyroid Hormone / Q000097:blood / Q000172:deficiency; D011547:Pseudohypoparathyroidism / Q000235:genetics / Q000378:metabolism*
D002864:Chromogranins; D010281:Parathyroid Hormone; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs