[Nitric oxide metabolism in the inclusion of N-acetylcysteine into the complex therapy of patients with community-acquired pneumonia].
Thirty-five patients with community-acquired pneumonia were examined. Studies of red blood cells and expired air condensate revealed significant nitric oxide metabolic disturbances in them. In a group of 17 patients, the use of N-acetylcysteine in the complex therapy resulted in the normalization of most parameters that characterized nitric oxide metabolism (nitrates, nitrites, peroxynitrite, NADP-H-diaphorase, and nitrate reductase activity). The positive changes were less significant in the control group receiving mucaltin instead of N-acetylcysteine. The established regularities in the balance change of nitric oxide metabolism in blood and expired air condensate at the height of the disease and positive changes during therapy including N-acetylcysteine suggest that nitric oxide plays an important role in the pathogenesis of community-acquired pneumonia.
A L
AL
Aliavi
G A
GA
Kurbanova
D000111:Acetylcysteine / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001944:Breath Tests / Q000379:methods; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D005100:Expectorants / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000378:metabolism*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D015415:Biomarkers; D005100:Expectorants; D016166:Free Radical Scavengers; D009569:Nitric Oxide; D000111:Acetylcysteine