Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport.
Transport of macromolecules between the nucleus and cytoplasm is a critical cellular process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is subject to multiple levels of control. Regulation is achieved by modulating the expression or function of single cargoes, transport receptors, or the transport channel. Each of these mechanisms has increasingly broad impacts on transport patterns and capacity, and this hierarchy of control directly affects gene expression, signal transduction, development, and disease.
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Laura J
LJ
Terry
Eric B
EB
Shows
Susan R
SR
Wente
D021581:Active Transport, Cell Nucleus; D000818:Animals; D006801:Humans; D028884:Karyopherins / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D049790:Nuclear Export Signals; D019913:Nuclear Localization Signals; D022022:Nuclear Pore / Q000378:metabolism* / Q000648:ultrastructure; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*
D028884:Karyopherins; D049790:Nuclear Export Signals; D019913:Nuclear Localization Signals; D028861:Nuclear Pore Complex Proteins; D012313:RNA