The Mx GTPase family of interferon-induced antiviral proteins.
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.
Haller
Otto
O
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herderstrasse 11, D-79008 Freiburg, Germany. otto.haller@uniklinik-freiburg.de
Stertz
Silke
S
Kochs
Georg
G
D000818:Animals; D000998:Antiviral Agents / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D004285:Dogs; D020558:GTP Phosphohydrolases / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000145:classification / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D064547:Myxovirus Resistance Proteins; D051381:Rats; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D007372:Interferons; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins