A method for the synthesis of an oseltamivir PET tracer.
A protocol applicable for the synthesis of an oseltamivir positron emission tomography (PET) tracer was developed. Acetylation of amine 3 with CH(3)COCl, followed by deprotection and aqueous workup, produced oseltamivir 4 from 3 within 10 min. The obtained 4 was sufficiently pure for PET studies. This method can be extended to PET tracer synthesis using CH(3)(11)COCl.
Morita
Masataka
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo, Tokyo 113-0033, Japan.
Sone
Toshihiko
T
Yamatsugu
Kenzo
K
Sohtome
Yoshihiro
Y
Matsunaga
Shigeki
S
Kanai
Motomu
M
Watanabe
Yasuyoshi
Y
Shibasaki
Masakatsu
M
D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D053139:Oseltamivir / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000737:chemistry*
D000998:Antiviral Agents; D011868:Radioisotopes; D053139:Oseltamivir