Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency.
We report a CD40 ligand deficiency (CD40LD) patient who was successfully treated with unrelated cord blood transplantation (URCBT). Conditioning regimen was busulfan and cyclophosphamide. The clinical course was uneventful and durable engraftment was achieved. This successful case encourages the use of URCB as an alternative donor source for CD40LD patients.
Tsuji
Yoichiro
Y
Department of Pediatrics, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan. ytsuji@ndmc.ac.jp
Imai
Kohsuke
K
Morinishi
Yoichi
Y
Kogawa
Kazuhiro
K
Morino
Masaaki
M
Nonoyama
Shigeaki
S
D000361:Agammaglobulinemia / Q000235:genetics / Q000628:therapy*; D002066:Busulfan / Q000008:administration & dosage; D019013:CD40 Antigens / Q000172:deficiency*; D036101:Cord Blood Stem Cell Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D007223:Infant; D019520:Living Donors; D008297:Male; D009503:Neutropenia / Q000235:genetics / Q000628:therapy*; D019172:Transplantation Conditioning
D019013:CD40 Antigens; D003520:Cyclophosphamide; D002066:Busulfan