Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal.
Previous studies have differed as to whether APOE epsilon4 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOE alleles on disease expression. Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon2 allele.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia. Needhm01@student.uwa.edu.au
Merrilee
M
Needham
Amanda
A
Hooper
Ian
I
James
Frank
F
van Bockxmeer
Alastair
A
Corbett
Timothy
T
Day
Michael J
MJ
Garlepp
Frank L
FL
Mastaglia
D017668:Age of Onset; D000483:Alleles; D053329:Apolipoprotein E2 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D018979:Myositis, Inclusion Body / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4