Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: Case Report.
We report a novel approach of fertility preservation in a young woman with mosaic Turner syndrome. A 16-year-old female with 20% 45XO and 80% 46XX karyotype underwent laparoscopic ovarian wedge resection. Before performing ovarian tissue cryopreservation, all visible follicles on the ovarian surface were aspirated. We recovered 11 immature germinal vesicle stage oocytes, which were subjected to in vitro maturation (IVM). Eight oocytes that matured (73% maturation rate) were cryopreserved by vitrification. The combination of ovarian tissue cryobanking and immature oocyte collection from the tissue followed by IVM and vitrification of matured oocytes represent a promising approach of fertility preservation for young women with mosaic Turner syndrome.
Department of Obstetrics and Gynecology, McGill University Health Center, McGill University, Montreal, Quebec, Canada H3A 1A1.
J Y J
JY
Huang
T
T
Tulandi
H
H
Holzer
N M
NM
Lau
S
S
Macdonald
S L
SL
Tan
R C
RC
Chian
D000293:Adolescent; D002478:Cells, Cultured; D016922:Cellular Senescence; D015925:Cryopreservation; D005260:Female; D006801:Humans; D009030:Mosaicism; D009865:Oocytes; D010053:Ovary; D014424:Turner Syndrome / Q000235:genetics*