Alport syndrome with recurrent herpes simplex virus keratitis.
OBJECTIVE
To report a case of Alport syndrome with recurrent herpes simplex virus (HSV) keratitis.


METHODS
Case report and review of the literature.


RESULTS
A 29-year-old man with Alport syndrome suffered from 4 consecutive episodes of HSV keratitis within 2 years. A type IV collagen defect in basement membranes plays an important role in the pathogenesis of Alport syndrome. The relationship between HSV keratitis and Alport syndrome is discussed. After remission from HSV keratitis, the patient underwent bilateral phacoemulsification and posterior-chamber intraocular lens implantation for anterior lenticonus and an anterior polar cataract. After surgery, the uncorrected visual acuity was 20/20 in both eyes.


CONCLUSIONS
We assume that the underlying basement membrane defects in Alport syndrome may account for the recurrent episodes of HSV keratitis in this patient. In addition, phacoemulsification and posterior-chamber intraocular lens implantation, rather than correction of refractive errors, provide a safe and efficient therapeutic choice for the management of anterior lenticonus, with or without associated cataract in patients with Alport syndrome.
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Pei-Chen
PC
Chung
Ken-Kuo
KK
Lin
Hu-Shien
HS
Song
Wan-Chen
WC
Ku
Samuel C M
SC
Huang
Chi-Chin
CC
Sun
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications* / Q000188:drug therapy; D019654:Lens Implantation, Intraocular; D008297:Male; D009394:Nephritis, Hereditary / Q000150:complications*; D018918:Phacoemulsification; D012008:Recurrence
D000998:Antiviral Agents; D000212:Acyclovir