[Clinical evaluation of the xMAP technology in detection of high-risk human papillomavirus].
OBJECTIVE
To evaluate the clinical application value of flexible multi-analyte profiling (xMAP) technology in detecting high-risk human papillomavirus (HR-HPV).


METHODS
Totally 1 061 women, aged 21-65 years, were randomly enrolled into the study. Cervical exfoliated cells were used in xMAP technology and hybrid capture II (hc2). Pathological diagnosis was used as golden standard. Consistency of these two methods was assessed.


RESULTS
The sensitivity and specificity of xMAP technology were 80.31% and 85.83%, respectively. The positive and negative predictive values were 44.5% and 96.9%, respectively. The Kappa value for consistency between xMAP technology and hc2 was 0.58.


CONCLUSIONS
The specificity of xMAP technology is similar to hc2 test, but the sensitivity is inferior to hc2. However, these two methods show good consistency in the detection of HR-HPV.
Department of Cancer Epidemiology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
Guang-dong
GD
Liao
Xiao-yan
XY
Zhang
Yu-hua
YH
Gao
Bin
B
Liu
Xia
X
Liu
Lian-kun
LK
Li
Feng
F
Chen
Mei-lu
ML
Bian
Wen
W
Chen
You-lin
YL
Qiao
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D012680:Sensitivity and Specificity; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000821:virology; D014773:Virology / Q000379:methods; D055815:Young Adult