Chromatin, gene silencing and HIV latency.
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms.
Mok
Hoi-Ping
HP
Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Lever
Andrew Ml
AM
D002843:Chromatin / Q000737:chemistry / Q000502:physiology*; D019175:DNA Methylation; D015870:Gene Expression; D020868:Gene Silencing; D005814:Genes, Viral; D006678:HIV / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D017735:Virus Latency / Q000235:genetics*
D002843:Chromatin