The effect of optical zone decentration on lower- and higher-order aberrations after photorefractive keratectomy in a cat model.
OBJECTIVE
To simulate the effects of decentration on lower- and higher-order aberrations (LOAs and HOAs) and optical quality, by using measured wavefront error (WFE) data from a cat photorefractive keratectomy (PRK) model.


METHODS
WFE differences were obtained from five cats' eyes 19 +/-7 weeks after spherical myopic PRK for -6 D (three eyes) and -10 D (two eyes). Ablation-centered WFEs were computed for a 9.0 mm pupil. A computer model was used to simulate decentration of a 6-mm subaperture in 100-microm steps over a circular area of 3000 microm diameter, relative to the measured WFE difference. Changes in LOA, HOA, and image quality (visual Strehl ratio based on the optical transfer function; VSOTF) were computed for simulated decentrations over 3.5 and 6.0 mm.


RESULTS
Decentration resulted in undercorrection of sphere and induction of astigmatism; among the HOAs, decentration mainly induced coma. Decentration effects were distributed asymmetrically. Decentrations >1000 microm led to an undercorrection of sphere and cylinder of >0.5 D. Computational simulation of LOA/HOA interaction did not alter threshold values. For image quality (decrease of best-corrected VSOTF by >0.2 log units), the corresponding thresholds were lower. The amount of spherical aberration induced by the centered treatment significantly influenced the decentration tolerance of LOAs and log best corrected VSOTF.


CONCLUSIONS
Modeling decentration with real WFE changes showed irregularities of decentration effects for rotationally symmetric treatments. The main aberrations induced by decentration were defocus, astigmatism, and coma. Treatments that induced more spherical aberration were less tolerant of decentration.
Bühren
Jens
J
Department of Ophthalmology, University of Rochester Medical Center, NY 14642, USA. jbuehren@cvs.rochester.edu
Yoon
Geunyoung
G
Kenner
Shawn
S
MacRae
Scott
S
Huxlin
Krystel
K
D000818:Animals; D001251:Astigmatism / Q000503:physiopathology*; D002415:Cats; D003198:Computer Simulation; D003315:Cornea / Q000503:physiopathology* / Q000601:surgery*; D019781:Corneal Topography; D054018:Lasers, Excimer; D008297:Male; D023421:Models, Animal; D009216:Myopia / Q000601:surgery; D018903:Photorefractive Keratectomy; D012029:Refraction, Ocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology