Uptake, elimination, and relative distribution of perchlorate in various tissues of channel catfish.
This study was undertaken to determine the kinetics of uptake and elimination of perchlorate in channel catfish, Ictalurus punctatus. Perchlorate--an oxidizer used in solid fuel rockets, fireworks, and illuminating munitions--has been shown to effect thyroid function, causing hormone disruption and potential perturbations of metabolic activities. For the uptake study, catfish were exposed to 100 mg/L sodium perchlorate for 12 h to 5 d in the laboratory. Perchlorate in tissues was analyzed using ion chromatography. The highest perchlorate concentrations were found in the head and fillet, indicating that these tissues are the most important tissues to analyze when determining perchlorate uptake into large fish. To calculate uptake and elimination rate constants for fillet, gills, G-I tract, liver, and head, fish were exposed to 100 ppm sodium perchlorate for 5 days, and allowed to depurate in clean water for up to 20 days. The animals rapidly eliminated the perchlorate accumulated showing the highest elimination in fillet (Ke = 1.67 day(-1)) and lowest elimination in liver (Ke = 0.79 day(-1)).
The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409-1163, USA.
June-Woo
JW
Park
Carrie M
CM
Bradford
Jacques
J
Rinchard
Fujun
F
Liu
Mike
M
Wages
Aaron
A
Waters
Ronald J
RJ
Kendall
Todd A
TA
Anderson
Christopher W
CW
Theodorakis
D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism; D005880:Gills / Q000378:metabolism; D006066:Gonads / Q000378:metabolism; D006257:Head; D007059:Ictaluridae / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010472:Perchlorates / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
D010472:Perchlorates; D014874:Water Pollutants, Chemical; C494474:perchlorate