TLR2 in murine atherosclerosis.
Atherosclerosis was once thought to be solely a disease of lipid accumulation in the vessel wall. It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis.
Tobias
Peter S
PS
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. tobias@scripps.edu
Curtiss
Linda K
LK
D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction; D051195:Toll-Like Receptor 2 / Q000276:immunology / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000276:immunology / Q000378:metabolism
D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4