Direct electrical measurements on single-molecule genomic DNA using single-walled carbon nanotubes.
A unique nanoelectronic platform, based on single-walled carbon nanotubes (SWNTs), has been fabricated for measuring electrical transport in single-molecule DNA. We have tested 80 base pairs of single- and double-stranded DNA (ssDNA and dsDNA, respectively) of complex base sequences. About a 25-40 pA current (at 1 V) was measured for the dsDNA molecule covalently attached to the SWNT electrode at its termini. In the absence of base pair stacking, a ssDNA carries a feeble current of approximately 1 pA or less. Gate-voltage-dependent I-V characteristics revealed that the bridging dsDNA molecule acts as a p-type channel between SWNT source and drain electrodes.
Department of Mechanical and Materials Engineering, Florida International University, Miami, Florida 33174, USA.
Somenath
S
Roy
Harindra
H
Vedala
Aparna Datta
AD
Roy
Do-Hyun
DH
Kim
Melissa
M
Doud
Kalai
K
Mathee
Hoon-kyu
HK
Shin
Nobuo
N
Shimamoto
Viswanath
V
Prasad
Wonbong
W
Choi
D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D023281:Genomics; D037742:Nanotubes, Carbon
D037742:Nanotubes, Carbon; D004247:DNA