Different strategies for the synthesis of 2'-O-aminoethyl adenosine building blocks.
The chemical modification of the 2'-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we investigated the synthesis of 2'-O-aminoethyl adenosine as a cationic modified building block.
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Dalibor
D
Odadzic
Joachim W
JW
Engels
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry; D020871:RNA Stability
D012313:RNA; D000241:Adenosine