How to improve the survival of the fetal ventral mesencephalic cell transplanted in Parkinson's disease?
It has been extensively confirmed that fetal ventral mesencephalic cell (VMC) transplantation can ameliorate the symptoms of Parkinson's disease (PD). But there are still several problems to be resolved before the extensive clinical application of this technology. The major limitations are the poor survival of grafted dopamine (DA) neurons and restricted dopaminergic reinnervation of host striatum. Some attempts have been made to solve these problems including use of some trophic factor and co-transplantation with neural/paraneural origins. The purpose of this review is to overview advances of the means improving the survival of grafts and their current limitations.
Beijing Hongtianji Neuroscience Academy, Beijing 100041, China.
Jia
J
Liu
Hong-Yun
HY
Huang
D000818:Animals; D016380:Brain Tissue Transplantation / Q000379:methods*; D053686:Fetal Stem Cells / Q000637:transplantation*; D016332:Fetal Tissue Transplantation / Q000379:methods*; D006085:Graft Survival; D006801:Humans; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation*; D010300:Parkinson Disease / Q000628:therapy*