Intracellular mediators of CXCR4-dependent signaling in T cells.
The signaling pathways induced in T lymphocytes by CXCR4-CXCL12 interaction, which lead to the cytoskeletal macro-rearrangements observable in migrating cells, are as yet largely uncharacterized. The aim of this review is to briefly summarize the current knowledge of the signaling machinery which controls the process of chemotaxis in CXCL12-stimulated T lymphocytes.
Patrussi
Laura
L
Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. patrussi2@unisi.it
Baldari
Cosima T
CT
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology*
D047908:Intracellular Signaling Peptides and Proteins; D011948:Receptors, Antigen, T-Cell; D019718:Receptors, CXCR4; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D020962:Heterotrimeric GTP-Binding Proteins