Characterization of an alginate-based drug delivery system for neurological applications.
This paper presents a drug delivery system based on alginate gels. The biocompatibility, the flexibility in size and shape, and the ability to entrap biomolecules make alginate-based systems ideal for in vivo drug delivery. Specifically, by considering the target application of neural regeneration and neuroprotection, the issue of biocompatibility as well as morphologic compatibility (e.g. shape and size of an implant) have to be addressed. The authors describe various types of alginate gels; fibers of cylindrical shape resulted the best choice in terms of simplicity of realization, insertion and release effectiveness, as shown by preliminary in vivo assays. Consequently, fibers release is tested in vitro and theoretically modelled, in order to obtain mathematical correlations between the release kinetics and key parameters affecting the realization procedure.
Ciofani
Gianni
G
CRIM (Center for Research in Microengineering) Lab, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy. g.ciofani@sssup.it
Raffa
Vittoria
V
Pizzorusso
Tommaso
T
Menciassi
Arianna
A
Dario
Paolo
P
D000464:Alginates / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002417:Cattle; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D008962:Models, Theoretical; D009422:Nervous System Diseases / Q000188:drug therapy*; D010316:Particle Size; D012709:Serum Albumin / Q000737:chemistry; D012995:Solubility
D000464:Alginates; D001672:Biocompatible Materials; D005782:Gels; D006603:Hexuronic Acids; D012709:Serum Albumin; D020723:Glucuronic Acid