Transposons for cancer gene discovery: Sleeping Beauty and beyond.
The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.
Collier
Lara S
LS
The Department of Genetics, Cell Biology and Development, The Cancer Center, The University of Minnesota Twin Cities, Church St SE, Minneapolis, Minnesota 55455, USA. lsc5e@alumni.virginia.edu
Largaespada
David A
DA
D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics*; D015321:Gene Rearrangement; D052138:Genes, Neoplasm; D006801:Humans; D016296:Mutagenesis; D019076:Transgenes; D019895:Transposases / Q000378:metabolism*
D004251:DNA Transposable Elements; D019895:Transposases