Mobile DNA elements in primate and human evolution.
Roughly 50% of the primate genome consists of mobile, repetitive DNA sequences such as Alu and LINE1 elements. The causes and evolutionary consequences of mobile element insertion, which have received considerable attention during the past decade, are reviewed in this article. Because of their unique mutational mechanisms, these elements are highly useful for answering phylogenetic questions. We demonstrate how they have been used to help resolve a number of questions in primate phylogeny, including the human-chimpanzee-gorilla trichotomy and New World primate phylogeny. Alu and LINE1 element insertion polymorphisms have also been analyzed in human populations to test hypotheses about human evolution and population affinities and to address forensic issues. Finally, these elements have had impacts on the genome itself. We review how they have influenced fundamental ongoing processes like nonhomologous recombination, genomic deletion, and X chromosome inactivation.
Xing
Jinchuan
J
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA.
Witherspoon
David J
DJ
Ray
David A
DA
Batzer
Mark A
MA
Jorde
Lynn B
LB
D000818:Animals; D005075:Biological Evolution; D002520:Cercopithecidae / Q000235:genetics; D005260:Female; D018732:Forensic Anthropology / Q000379:methods; D005828:Genetics, Population / Q000379:methods; D016678:Genome; D015186:Hominidae / Q000235:genetics; D006801:Humans; D008297:Male; D010802:Phylogeny; D051078:Platyrrhini / Q000235:genetics; D011323:Primates / Q000235:genetics*; D018626:Retroelements; D011443:Strepsirhini / Q000235:genetics; D016699:Tarsiidae / Q000235:genetics
D018626:Retroelements