Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women.
IGF-1 levels increased, and IGF-2 and IGFBP-3 levels remained unchanged, in postmenopausal women following oophorectomy. The increase in IGF-1 likely results from decreased ovarian steroidogenic precursors resulting from removal of the hormonally active ovary. This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California, USA. robinfogle@yahoo.com
Robin H
RH
Fogle
Lilly
L
Chang
Sherfaraz K
SK
Patel
Frank Z
FZ
Stanczyk
Richard J
RJ
Paulson
D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood*; D011184:Postoperative Period
D012739:Gonadal Steroid Hormones; D007334:Insulin-Like Growth Factor I