Association of elevated plasma B-type natriuretic peptide levels with paroxysmal atrial fibrillation in patients with nonobstructive hypertrophic cardiomyopathy.
OBJECTIVE
To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients.


METHODS
Patients (n=97) were classified into chronic AF (CAF; n=14), paroxysmal AF (PAF; n=18) and normal sinus rhythm (NSR; n=65) groups. The plasma BNP values were analyzed with logarithmic transformation.


RESULTS
The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; -l SD and +1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p<0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p<0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level.


CONCLUSIONS
The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Hiroko
H
Matsuura
Takashi
T
Murakami
Kazuyoshi
K
Hina
Keizo
K
Yamamoto
Hiroshi
H
Kawamura
Taiji
T
Sogo
Ryoko
R
Shinohata
Shinichi
S
Usui
Yoshifumi
Y
Ninomiya
Shozo
S
Kusachi
D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D002908:Chronic Disease; D015150:Echocardiography, Doppler; D005260:Female; D015200:Fluoroimmunoassay; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D013614:Tachycardia, Paroxysmal / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain