Molecular characterization of three new virulent Newcastle disease virus variants isolated in China.
Three cases of Newcastle disease virus (NDV) found in nature had the lentogenic motif (112)G-R-Q-G-R-L(117) in their fusion protein cleavage sites. However, both intracerebral pathogenicity and intravenous pathogenicity indexes showed that these NDV isolates were virulent. In comparison with the LaSota live virus vaccine, these viruses had significant genetic variations in the hemagglutinin-neuraminidase gene.
Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Lei-Tao
LT
Tan
Huai-Ying
HY
Xu
You-Ling
YL
Wang
Zhuo-Ming
ZM
Qin
Lei
L
Sun
Wen-Jun
WJ
Liu
Zhi-Zhong
ZZ
Cui
D020816:Amino Acid Motifs; D000818:Animals; D001717:Birds; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D015707:HN Protein / Q000235:genetics*; D008969:Molecular Sequence Data; D009521:Newcastle Disease / Q000453:epidemiology / Q000821:virology*; D009522:Newcastle disease virus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014760:Viral Fusion Proteins / Q000235:genetics*; D014774:Virulence
D015707:HN Protein; D014760:Viral Fusion Proteins