Efficient synthesis of highly substituted Pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones.
A convenient and efficient synthesis of highly substituted pyrrolin-4-ones is developed via the PIFA-mediated cyclization reactions of readily available enaminones, and a mechanism involving sequential cleavage of N-C bond, formation of new N-C bond, intramolecular addition reaction, and benzilic acid type rearrangement is proposed.
Huang
Jie
J
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Liang
Yongjiu
Y
Pan
Wei
W
Yang
Yang
Y
Dong
Dewen
D