Pathogenesis of Campylobacter.
OBJECTIVE
Molecular pathogenesis of Campylobacter jejuni has lagged behind that of other enteric pathogens. This review summarizes advances in the biology and pathogenesis of C. jejuni.


RESULTS
Multiple genome sequences have defined conserved and hypervariable loci in the C. jejuni genome. Interaction of C. jejuni with eukaryotic cells results in numerous signal transduction changes and release of proinflammatory cytokines. In-vivo models based on immune knockout mice have also revealed new information on pathogenesis.


CONCLUSIONS
New information and new methods are available that should provide important tools to further understand pathogenesis of this elusive pathogen.
Poly
Frédéric
F
Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA.
Guerry
Patricia
P
D000818:Animals; D002167:Campylobacter / Q000235:genetics* / Q000472:pathogenicity*; D002169:Campylobacter Infections / Q000382:microbiology*; D003967:Diarrhea / Q000382:microbiology*; D004195:Disease Models, Animal; D005407:Flagella / Q000235:genetics; D016680:Genome, Bacterial; D023281:Genomics; D054884:Host-Pathogen Interactions; D006801:Humans; D051379:Mice; D017422:Sequence Analysis, DNA; D014774:Virulence / Q000235:genetics