Posttraumatic stress disorder with secondary psychotic features: neurobiological findings.
The neurobiological knowledge on the potentially new diagnostic entity "posttraumatic stress disorder with secondary psychotic features" (PTSD-SP) is reviewed. Studies published between 1980 and 2006 were traced focussing on adult patients suffering from this "syndrome". Studies on cortisol, corticotrophin releasing hormone, dopamine beta-hydroxylase, smooth pursuit eye movements and psychopharmacology are described and potential pathophysiological mechanisms briefly discussed. More research is needed to validate the nosological status of PTSD-SP in order to promote neurobiological research and adequate therapeutic interventions.
Braakman
Mario H
MH
Institute of Mental Health Care, Wolfheze, the Netherlands and Department of Psychiatry, Radboud University Nijmegen Medical Center, Wolfheze 2, 6874 BE, Wolfheze, The Netherlands. m.braakman@degelderseroos.nl
Kortmann
Frank A M
FA
van den Brink
Wim
W
Verkes
Robbert J
RJ
D015415:Biomarkers; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D011618:Psychotic Disorders / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D011698:Pursuit, Smooth / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*
D015415:Biomarkers; D003346:Corticotropin-Releasing Hormone; D004299:Dopamine beta-Hydroxylase; D006854:Hydrocortisone