Procalcitonin (PCT) and C-reactive protein (CRP) as severe systemic infection markers in febrile neutropenic adults.
BACKGROUND
Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile.


METHODS
52 adult patients were enrolled in the study. Blood sample was collected in order to determine the serum concentrations of PCT, CRP and other hematological parameters at the onset of fever. The patients were divided into 2 groups, one with severe infection (n = 26) and the other in which the patients did not present such an infection (n = 26). Then PCT and CRP concentrations at the fever onset were compared between groups using non parametric statistical tests, ROC curve, sensitivity, specificity, likelihood ratio, and Spearman's correlation coefficient.


RESULTS
The mean of PCT was significantly higher in the group with severe infection (6.7 ng/mL versus 0.6 ng/mL - p = 0.0075) comparing with CRP. Serum concentrations of 0.245 ng/mL of PCT displayed 100% de sensitivity and 69.2% specificity. PCT concentrations of 2,145 ng/mL presented a likelihood ratio of 13, which was not observed for any concentration of CRP.


CONCLUSIONS
PCT seems to be an useful marker for the diagnosis of systemic infection in febrile neutropenic patients, probably better than CRP.
Disciplina de Hematologia e Hemoterapia - Departamento de Clínica Médica at the Faculty of Medicine of the University of São Paulo, Brazil. rukarin.massaro@uol.com.br
Karin S R
KS
Massaro
Silvia F
SF
Costa
Claudio
C
Leone
Dalton A F
DA
Chamone
D000328:Adult; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005334:Fever / Q000209:etiology; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000209:etiology*; D009894:Opportunistic Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011498:Protein Precursors / Q000097:blood*; D013223:Statistics as Topic
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide