FoxO3 controls dangerous proteolytic liaisons.
FoxO3 regulates the transcription of critical components of the ubiquitin-proteasome system in muscle wasting. Two reports (Mammucari et al., 2007; Zhao et al., 2007) now implicate FoxO3 in the transcription of autophagy-related genes and provide the first direct evidence for a coordinated role of autophagy in muscle atrophy.
Institut National de la Recherche Agronomique, UMR1019, Proteolysis Group, 63122 Ceyrat, France. attaix@clermont.inra.fr
Didier
D
Attaix
Daniel
D
Bechet
D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000209:etiology; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism
C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; C474033:FoxO3 protein, mouse; D025801:Ubiquitin; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex