Magnetic-sensitive silica nanospheres for controlled drug release.
Recently, magnetic silica-based nanospheres have received great attention and displayed magnificent potential for bioimaging and therapeutic purposes. This study provided a way to accelerate drug release from magnetic-sensitive silica nanospheres by controlled bursting to a therapeutically effective concentration by a high-frequency magnetic field (HFMF). The magnetic-sensitive silica nanospheres were synthesized by an in situ process, with particle sizes about 50 nm and able to release specific amounts of drug in a burst manner via short exposure to a HFMF. The HFMF accelerates the rotation of magnetic nanoparticles deposited in the silica matrix with generated heat energy and subsequently enlarges the nanostructure of the silica matrix to produce porous channels that cause the drug to be released easily. By taking these magnetic-responsive controllable drug release behaviors, the magnetic silica nanospheres can be designed for controlled burst release of therapeutic agents for especially urgent physiological needs.
Department of Materials Sciences and Engineering, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu, Taiwan, Republic of China.
Shang-Hsiu
SH
Hu
Ting-Yu
TY
Liu
Hsin-Yang
HY
Huang
Dean-Mo
DM
Liu
San-Yuan
SY
Chen
D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008280:Magnetics; D008854:Microscopy, Electron; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013997:Time Factors
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide