Scleritis and peripheral ulcerative keratitis.
Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and require early diagnosis and treatment. Nearly two thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy and one fourth need a glucocorticoid-sparing agent as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. A detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are important in the exclusion of underlying disorders and extraocular involvement.
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, 550 North Broadway, Suite 700, Baltimore, MD 21205, USA.
Anat
A
Galor
Jennifer E
JE
Thorne
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000453:epidemiology; D015897:Comorbidity; D003320:Corneal Ulcer / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015423:Scleritis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids