Onset of streptococcal toxic shock syndrome is accelerated by bruising in a mouse model.
Streptococcal toxic shock syndrome (STSS) is the severest form of human infections caused by Streptococcus pyogenes. In our animal model of STSS [Saito M, Kajiwara H, Ishikawa T, et al. Delayed onset of systemic bacterial dissemination and subsequent death in mice injected intramuscularly with Streptococcus pyogenes. Microbiol Immunol 2001;45:777-86], mice inoculated intramuscularly with S. pyogenes strains initially suffer from a short illness, then recover and remain healthy for about 20 days, and finally become sick and incur a sudden death. Here we report that the death during the convalescent period was facilitated by artificially bruising an extremity remote from the site of the initial inoculation. Bacterial burden was found to be higher in the bruised site than in a non-bruised control extremity of each mouse examined. Bacteremia started to occur approximately 20 days after infection. These findings imply that a fresh bruise serves as a focus for bacterial multiplication in the presence of bacteremia, thereby facilitating the development of STSS.
Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Masanori
M
Seki
Mitsumasa
M
Saito
Ken-Ichiro
K
Iida
Hiroaki
H
Taniai
Takashi
T
Soejima
Hiroaki
H
Nakayama
Shin-Ichi
S
Yoshida
D000818:Animals; D016470:Bacteremia / Q000382:microbiology / Q000503:physiopathology; D003288:Contusions / Q000150:complications* / Q000473:pathology; D003645:Death, Sudden; D004195:Disease Models, Animal; D006801:Humans; D007866:Leg / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D012772:Shock, Septic / Q000382:microbiology* / Q000503:physiopathology*; D013290:Streptococcal Infections / Q000382:microbiology / Q000473:pathology*; D013297:Streptococcus pyogenes