Transcriptional regulation.
The regulation of transcription in C. elegans shares many similarities to transcription in other organisms. The details of how specific transcription factors bind to target promoters and act as either activators or repressors are still being examined in many cases, but an increasing number of factors and their binding sites are being characterized. This chapter reviews the general concepts that have emerged with regards to promoter function in C. elegans. Included are the methods that have been successfully employed as well as limitations encountered to date. Specific cis-acting promoter elements from myo-2, hlh-1 and lin-26 are discussed as examples of complex promoters regulated by multiple sequence elements. In addition, examples of organ-, tissue-, and cell type-specific mechanisms for generating spatial specificity in gene expression are discussed.
Laboratory of Molecular Biology, University of Illinois at Chicago, Chicago, IL 60607, USA. okkema@uic.edu
Peter G
PG
Okkema
Michael
M
Krause
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D018509:DNA, Helminth; D005786:Gene Expression Regulation; D017238:Genes, Helminth; D006801:Humans; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D015534:Trans-Activators / Q000502:physiology; D014158:Transcription, Genetic
D018509:DNA, Helminth; D015534:Trans-Activators