The chemical toxicology of 2-deoxyribose oxidation in DNA.
Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its potential role in the development of human disease. Only recently, though, have we begun to appreciate that oxidation of the 2-deoxyribose moiety in DNA is also a determinant of the genetic toxicology of oxidative stress and inflammation, with involvement in more than just "strand breaks", such as complex DNA lesions, protein-DNA cross-links, and protein and DNA adducts. As an update to a 1992 review of 2'-deoxyribose oxidation by bleomycin and the enediynes published in Chemical Research in Toxicology [Dedon, P. C., and Goldberg, I. H. (1992) Chem. Res. Toxicol. 5, 311-332], this review focuses on recent developments in the chemical biology, bioanalytical chemistry, and genetic toxicology of 2-deoxyribose oxidation products in DNA under biologically relevant conditions.
Dedon
Peter C
PC
Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, USA. pcdedon@mit.edu
D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D004249:DNA Damage; D003855:Deoxyribose / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008956:Models, Chemical; D010084:Oxidation-Reduction; D012313:RNA / Q000187:drug effects; D012997:Solvents
D012997:Solvents; D003855:Deoxyribose; D012313:RNA; D004247:DNA; D005982:Glutathione Transferase; D005978:Glutathione