[Parathyroid and bone. Indication for parathyroidectomy in primary hyperparathyroidisms].
Primary hyperparathyroidism is a disease in which somatic chromosomal defects such as activations of oncogenes or inactivations of tumor suppressor genes enhance chromosomal parathyroid cell growth. Decreased calcium-sensing receptor causes oversecretion of PTH from abnormal parathyroid cells. Oversecreted PTH enhances bone turnover and finally exhibits bone fragility. In this review, the indications of parathyroidectomy and the effects of parathyroidectomy on bone in primary hyperparathyroidism are discussed.
Osaka City University Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine.
Yasuo
Y
Imanishi
D015519:Bone Density; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D010281:Parathyroid Hormone / Q000378:metabolism / Q000502:physiology; D016105:Parathyroidectomy; D044169:Receptors, Calcium-Sensing / Q000502:physiology
D010281:Parathyroid Hormone; D044169:Receptors, Calcium-Sensing