[Genital herpes and HSV transmission in HIV patients].
There is a bidirectional relationship between HSV-2 and HIV-1, both at the cellular level, as well as regarding transmission and even progression of HIV-1 infection. There is clear evidence that anti-herpetic therapy reduces the plasma and mucosal HIV-1 viral load, as well as transmission. Serologic testing for HSV-2 in patients with an increased HIV-1 risk, coupled with a better understanding of the interaction between the viruses and appropriate anti-herpetic suppression therapy could both reduce the HIV-1 transmission rate and help the individual with an HIV infection.
Institut für Medizinische Virologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Paul-Ehrlich-Strasse 40, 60596 Frankfurt. rabenau@em.uni-frankfurt.de
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D015897:Comorbidity; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D015658:HIV Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission*; D015497:HIV-1; D006558:Herpes Genitalis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission*; D018258:Herpesvirus 2, Human; D006801:Humans; D015994:Incidence; D038622:Internationality; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors