Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder.
BACKGROUND
Treatment with the atypical antipsychotic risperidone can result in elevated prolactin levels. To date, the relationships between plasma concentrations of prolactin, risperidone and its active 9-hydroxy-metabolite have been little investigated in adolescents with psychosis.


METHODS
Prolactin levels were determined at baseline in 16 hospitalized drug-naïve adolescents meeting DSM-IV criteria for schizophreniform disorder. Prolactin, risperidone, 9-hydroxyrisperidone levels were subsequently determined after 3 weeks of oral risperidone treatment.


RESULTS
Compared with pretreatment values, prolactin levels at endpoint were significantly increased (p<0.00001) and correlated with risperidone doses (r=0.58, N=16, p<0.02), and plasma levels of risperidone (r=0.60, N=16, p<0.02) and 9-hydroxyrisperidone (r=0.54, N=16, p=0.03).


CONCLUSIONS
These data suggest that risperidone's effect on prolactin release is dose-dependent in adolescents and is linked to both plasma risperidone and 9-hydroxyrisperidone concentrations.
Duval
Fabrice
F
Centre Hospitalier, Secteur VIII, 27 Rue du 4ème Spahis Marocain, 68250 Rouffach, France. f.duval@ch-rouffach.fr
Guillon
Marie-Sabine
MS
Mokrani
Marie-Claude
MC
Crocq
Marc-Antoine
MA
Garcia Duarte
Frederico
F
D000293:Adolescent; D000295:Adolescent Medicine; D000367:Age Factors; D014150:Antipsychotic Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007555:Isoxazoles / Q000097:blood*; D008297:Male; D000068882:Paliperidone Palmitate; D011388:Prolactin / Q000097:blood* / Q000187:drug effects; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy; D011743:Pyrimidines / Q000097:blood*; D018967:Risperidone / Q000378:metabolism / Q000493:pharmacokinetics*
D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D011388:Prolactin; D018967:Risperidone; D000068882:Paliperidone Palmitate