Closed-loop control in fused MR-TRUS image-guided prostate biopsy.
Multi-modality fusion imaging for targeted prostate biopsy is difficult because of prostate motion during the biopsy procedure. A closed-loop control mechanism is proposed to improve the efficacy and safety of the biopsy procedure, which uses real-time ultrasound and spatial tracking as feedback to adjust the registration between a preoperative 3D image (e.g. MRI) and real-time ultrasound images. The spatial tracking data is used to initialize the image-based registration between intraoperative ultrasound images and a preoperative ultrasound volume. The preoperative ultrasound volume is obtained using a 2D sweep and manually registered to the MRI dataset before the biopsy procedure. The accuracy of the system is 2.3 +/- 0.9 mm in phantom studies. The results of twelve patient studies show that prostate motion can be effectively compensated using closed-loop control.
Philips Research North America, Briarcliff, NY 10510, USA. sheng.xu@philips.com
Sheng
S
Xu
Jochen
J
Kruecker
Peter
P
Guion
Neil
N
Glossop
Ziv
Z
Neeman
Peter
P
Choyke
Anurag K
AK
Singh
Bradford J
BJ
Wood
D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012007:Rectum / Q000000981:diagnostic imaging; D013382:Subtraction Technique / Q000295:instrumentation; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods; D014584:User-Computer Interface