[The recovery parameters of DNA strand breaks of Ehrlich ascites cells after the combined action of ionizing radiation and hyperthermia].
A mathematical model of DNA strand breaks postirradiation repair and the methodology allowing to differentiate the mechanism of inhibition of DNA strand breaks recovery after combined actions of ionizing radiation and hyperthermia have been described in this paper. Using this model and the results published by other authors for DNA strand breaks of Ehrlich ascites cells, there have been obtained the data showing that the portion of DNA-damages that the cell incapable to recover after consecutive thermoradiation action was risen with an increase in thermal load under insignificant change of repair constant. It means the mechanism of DNA strand breaks recovery inhibition is realized in a greater extent through the formation of irreversible damages but not through the damage of repair process itself.
Komarova
L N
LN
Petin
V G
VG
Saenko
A S
AS
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D053960:DNA Breaks; D004260:DNA Repair / Q000528:radiation effects; D006358:Hot Temperature; D051379:Mice; D008954:Models, Biological; D011839:Radiation, Ionizing