[Investigation of Mycobacterium tuberculosis sensitivity to fluoroquinolone, by revealing gyrA gene mutations].
The resistance of Mycobacterium tuberculosis (MBT) to fluoroquinolones is associated with the mutations concentrated in the gyrA gene that is a structural gene of a gyrase A subunit. Detection of mutations in this portion of the gene allows the sensitivity of MBT to this group of drugs to be rapidly determined.
Nosova
E Iu
EIu
Galkina
K Iu
KIu
Markova
O V
OV
Griadunov
D A
DA
Skotnikova
O I
OI
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D027081:DNA Gyrase / Q000235:genetics*; D004252:DNA Mutational Analysis; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology*
D000893:Anti-Inflammatory Agents; D024841:Fluoroquinolones; D027081:DNA Gyrase