[The expression of MMP-2, E-cadherin in supraglottic carcinoma and their relationship with cervical lymph node metastasis].
OBJECTIVE
To study the expressions of matrix metalloproteinase-2 (MMP-2) and E-cadherin in laryngeal carcinoma and their relationship with cervical lymph node metastasis.


METHODS
The expression of MMP-2 and E-cadherin in 10 cases of normal laryngeal mucosa and 48 cases of supraglottic carcinoma were detected by immunohistochemistry.


RESULTS
The expression of MMP-2 in supraglottic carcinoma was significantly higher than that in normal laryngeal mucosa. The expression of MMP-2 in metastatic lymph nodes was significantly higher than that in nonmetastatic lymph nodes (P < 0.05). The expression of E-cadherin was significantly lower in supraglottic carcinoma than that in normal laryngeal mucosa. The expression of E-cadherin was significantly lower in metastatic lymph nodes than that in nonmetastatic lymph nodes (P < 0.05). There is a negative correlation between the expression of MMP-2 and E-cadherin (r = -0.41). Predicting the lymph node metastasis of laryngeal carcinoma with the index of MMP-2(+), E-cadherin(-) and MMP-2(+), E-cadherin(-). MMP-2(+) has the highest sensitivity, but the lowest specificity and positive predictive value. MMP-2(+), E-cadherin(-) has the highest specificity and positive predictive value, but the lowest sensitivity.


CONCLUSIONS
Expression of MMP-2 and E-cadherin can be used as a marker to predict lymph node metastasis of supraglottic carcinoma. Combined the detection of MMP-2 and E-cadherin can boost the accuracy of prediction of lymph node metastasis in supraglottic carcinoma and provide efficient assistance for resecting supraglottic carcinoma.
Department of Otolaryngology, the Fourth People' s Hospital, Wuxi, 214062, China.
Changling
C
Sun
Ding
D
Xin
Yan
Y
Wang
D015820:Cadherins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D011379:Prognosis
D015820:Cadherins; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2