Efficient synthesis of highly substituted Pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones.
A convenient and efficient synthesis of highly substituted pyrrolin-4-ones is developed via the PIFA-mediated cyclization reactions of readily available enaminones, and a mechanism involving sequential cleavage of N-C bond, formation of new N-C bond, intramolecular addition reaction, and benzilic acid type rearrangement is proposed.
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Jie
J
Huang
Yongjiu
Y
Liang
Wei
W
Pan
Yang
Y
Yang
Dewen
D
Dong