Psoriasis is associated with increased beta-defensin genomic copy number.
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
Edward J
EJ
Hollox
Ulrike
U
Huffmeier
Patrick L J M
PL
Zeeuwen
Raquel
R
Palla
Jesús
J
Lascorz
Diana
D
Rodijk-Olthuis
Peter C M
PC
van de Kerkhof
Heiko
H
Traupe
Gys
G
de Jongh
Martin
M
den Heijer
André
A
Reis
John A L
JA
Armour
Joost
J
Schalkwijk
D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
C106641:DEFB4A protein, human; D023083:beta-Defensins