[The experimental models of Parkinson's disease in animals].
The current review describes the modem Parkinson's disease models in animals, their advantages, limitations and disadvantages. It was noted that the most widespread up-to-date models based on etiology of the Parkinson's disease. Although toxins mostly produce the Parkinson's disease, a study of involved genes allows investigating not only inherited but also sporadic (not inherited) forms of disease since the same genes are involved in both cases. Mutations of genes lead to formation of "mutant" toxic proteins, which produce a death of the specialized neurons of the nigrostriatal dopaminergic system and the development of Parkinson's disease. A significant place in the review takes adescription of characteristics of the toxic models produced by 6-OHDA, MPTP and rotenone, their similarities and differences in pathogenetic mechanisms of the Parkinson's disease development. On the basis of the considered experimental models of Parkinson's disease a conclusion has been done that none of these models may in full and adequate scale imitate the entire clinical, pathophysiological, morphological, biochemical and other aspects of the Parkinson's disease development.
G A
GA
Grigor'ian
A S
AS
Bazian
D000818:Animals; D005796:Genes / Q000235:genetics; D020267:MPTP Poisoning; D009154:Mutation; D009410:Nerve Degeneration / Q000473:pathology; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics / Q000473:pathology; D011506:Proteins / Q000235:genetics; D012402:Rotenone / Q000633:toxicity
D011506:Proteins; D012402:Rotenone; D016627:Oxidopamine