Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting.
Muscle wasting, characterized by the loss of protein mass in myofibers, is in most cases largely due to the activation of intracellular protein degradation by the ubiquitin proteasome system (UPS). During the last decade, mechanisms contributing to this activation have been unraveled and key mediators of this process identified. Even though much remains to be understood, the available information already suggests screens for new compounds inhibiting these mechanisms and highlights the potential for pharmaceutical drugs able to treat muscle wasting when it becomes deleterious. This review presents an overview of the main pathways contributing to UPS activation in muscle and describes the present state of efforts made to develop new strategies aimed at blocking or slowing muscle wasting. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Nury
David
D
CRBM-CNRS UMR5237, IFR22, 1919 route de Mende, 34000 Montpellier, France. david.nury@crbm.cnrs.fr
Doucet
Christine
C
Coux
Olivier
O
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009133:Muscular Atrophy / Q000188:drug therapy / Q000201:enzymology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors; D043743:Ubiquitin-Protein Ligase Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004791:Enzyme Inhibitors; D061988:Proteasome Inhibitors; D043743:Ubiquitin-Protein Ligase Complexes; D046988:Proteasome Endopeptidase Complex