Opposing regulation of pair bond formation by cAMP signaling within the nucleus accumbens shell.
The formation of monogamous pair bonds, by prairie voles, is facilitated by activation of dopamine (DA) D2-like, but not D1-like, receptors within the nucleus accumbens (NAcc) shell. Because DA exerts opposing regulation of cAMP production depending on the subtype of receptor activated, we tested the hypothesis that DA regulation of pair bond formation is mediated via the cAMP signaling cascade. Consistent with activation of D2-like receptors, decreasing cAMP signaling, by blocking cAMP binding sites on protein kinase A (PKA), facilitated partner preference formation. Conversely, increasing cAMP signaling, by preventing the activation of inhibitory G-proteins, activating stimulatory G-proteins, or stimulating PKA prevented the formation of mating-induced partner preferences. These manipulations were effective in the shell, but not the core, of the NAcc. Together, these data demonstrate opposing regulation over pair bond formation by cAMP signaling within the NAcc shell.
Aragona
Brandon J
BJ
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306-1270, USA.
Wang
Zuoxin
Z
D000818:Animals; D003411:Arvicolinae; D001522:Behavior, Animal; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D010052:Ovariectomy / Q000379:methods; D010152:Pair Bond; D037342:Pertussis Toxin / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D015398:Signal Transduction / Q000502:physiology*; D013238:Stereotaxic Techniques; D013873:Thionucleotides / Q000494:pharmacology
D047428:Protein Kinase Inhibitors; D013873:Thionucleotides; C016957:adenosine-3',5'-cyclic phosphorothioate; D002772:Cholera Toxin; D000242:Cyclic AMP; D037342:Pertussis Toxin