CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease.
The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). This review discusses the above relationship, highlighting (1) the gene mapping and molecular structure of CD200 and CD200R, (2) the distribution and expression of CD200 and CD200R in the nervous system, (3) the effect of CD200-CD200R signaling on microglia activation, and (4) the role of microglia activation in the pathogenesis and progression of PD. Finally, we discuss the status of current studies on the regulation of microglia activation in PD and strongly suggest that it is very promising to regulate microglia activation in PD via targeting CD200-CD200R signaling pathways.
Department of Neurology & Institute of Neurology, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
Xi-Jin
XJ
Wang
Min
M
Ye
Yu-Hong
YH
Zhang
Sheng-Di
SD
Chen
D000818:Animals; D015703:Antigens, CD / Q000502:physiology* / Q000627:therapeutic use; D000954:Antigens, Surface / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D017628:Microglia / Q000378:metabolism* / Q000502:physiology; D064446:Orexin Receptors; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011956:Receptors, Cell Surface / Q000502:physiology* / Q000627:therapeutic use
D015703:Antigens, CD; D000954:Antigens, Surface; C477337:CD200R1 protein, human; D064446:Orexin Receptors; D011956:Receptors, Cell Surface; C042739:antigens, CD200