[Natriuretic peptides: their role in diagnosis and therapy].
Cardiac natriuretic peptide hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are synthesized and secreted by the heart, producing several biological effects, such as natriuresis, vasorelaxation and hypotension. During the last decade these peptides, especially BNP, have received increasing attention as potential markers of cardiovascular disease. Their measurements can be used to diagnose heart failure, including diastolic dysfunction, and using them has been shown to save money. BNP levels can enable the differentiation between dyspnoic patients secondary to ventricular dysfunction and subjects with primary respiratory disorders. Moreover, there is good evidence that natriuretic peptides may have a diagnostic role in arterial hypertension, acute coronary syndromes, pulmonary hypertension, some valvular heart disease and some disorders affecting other systems (diabetes or thyroid disorders). In this paper we discuss the clinical utility of assessment of natriuretic peptide hormones in the diagnosis of various clinical conditions and their use as pharmacological agents.
Pakuła
Dorota
D
II Oddział Chorób Wewnetrznych z Pododdziałem Endokrynologii i Diabetologii, Wojewódzki Szpital Specjalistyczny nr 3, Rybnik. pakdor@interia.pl
Marek
Bogdan
B
Kajdaniuk
Dariusz
D
Kos-Kudła
Beata
B
Borgiel-Marek
Halina
H
Krysiak
Robert
R
Gatnar
Aleksander
A
Pakuła
Piotr
P
D009320:Atrial Natriuretic Factor / Q000502:physiology / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000502:physiology / Q000627:therapeutic use; D045265:Natriuretic Peptides / Q000502:physiology* / Q000627:therapeutic use*
D015415:Biomarkers; D002317:Cardiovascular Agents; D045265:Natriuretic Peptides; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor