Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy.
Accumulating evidence suggests that neurodegenerative diseases of the central nervous system (CNS) are associated with a local inflammatory response. CNS autoimmune diseases are also associated with inflammation. Does this mean that all neurodegenerative diseases are autoimmune in nature? Does it imply that autoimmune and neurodegenerative diseases are both eligible for the same therapy? What distinguishes between the two types of disease? Do they differ both in etiology and in pathology, or do they have different etiologies but similar pathology and progression? In this minireview we offer a new view of the inflammatory differences between neurodegenerative and autoimmune diseases in the CNS and discuss the implications for therapy.
Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel. michal.schwartz@weizmann.ac.il
Michal
M
Schwartz
Oleg
O
Butovsky
Jonathan
J
Kipnis
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use
D014612:Vaccines