Antioxidant enzyme activities following acute or chronic methylphenidate treatment in young rats.
Methylphenidate (MPH) is psychostimulants used to treat Attention-Deficit/Hyperactivity Disorder and can lead to a long-lasting neurochemical and behavioral adaptations in experimental animals. In the present study, the cerebral antioxidant enzymatic system, superoxide dismutase (SOD) and catalase (CAT) was evaluated at in different age following MPH (1, 2 or 10 mg/kg MPH, i.p.) treatment in young rats. In the acute treatment the SOD activity decreased in the cerebral prefrontal cortex with opposite effect in the cerebral cortex; and the CAT activity decreased in hippocampus. In the chronic treatment the SOD activity increased in the hippocampus and cerebral cortex and decreased in the striatum. The observed changes on the enzyme activities in rat brain were dependent on the structure brain region and duration of treatment with MPH. Probably, the activity of enzymes was not be enough to prevent MPH-induced oxidative damage in specific regions from brain, such as observed for us in another recent study.
Gomes
Karin M
KM
Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciuma, SC, Brazil.
Petronilho
Fabrícia C
FC
Mantovani
Mariane
M
Garbelotto
Thereza
T
Boeck
Carina R
CR
Dal-Pizzol
Felipe
F
Quevedo
João
J
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology; D002374:Catalase / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000378:metabolism* / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008774:Methylphenidate / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D000697:Central Nervous System Stimulants; D007527:Isoenzymes; D008774:Methylphenidate; D002374:Catalase; D013482:Superoxide Dismutase