Toward 'SMART' stem cells.
Stem cell research is at the heart of regenerative medicine, which holds great promise for the treatment of many devastating disorders. However, in addition to hurdles posed by well-publicized ethical issues, this emerging field presents many biological challenges. What is a stem cell? How are embryonic stem cells different from adult stem cells? What are the physiological bases for therapeutically acceptable stem cells? In this editorial review, I will briefly discuss these superficially simple but actually rather complex issues that surround this fascinating cell type. The goal of this special issue on stem cells in Gene Therapy is to review some fundamental and critical aspects of current stem cell research that have translational potential.
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Department of Radiation Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA. chengt@upmc.edu
D019070:Cell Lineage; D015316:Genetic Therapy; D006801:Humans; D012106:Research; D033581:Stem Cell Transplantation / Q000639:trends*; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering