Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome.
BACKGROUND
Most patients with sepsis develop potentially irreversible cerebral dysfunctions. It is yet not clear whether cerebral haemodynamics are altered in these sepsis patients at all, and to what extent. We hypothesized that cerebral haemodynamics and carbon dioxide reactivity would be impaired in patients with sepsis syndrome and pathological electroencephalogram patterns.


METHODS
After approval of the institutional ethics committee, 10 mechanically ventilated patients with sepsis syndrome and pathological electroencephalogram patterns underwent measurements of cerebral blood flow and jugular venous oxygen saturation before and after reduction of the arterial carbon dioxide partial pressure by 0.93 +/- 0.7 kPa iu by hyperventilation. The cerebral capillary closing pressure was determined from transcranial Doppler measurements of the arterial blood flow of the middle cerebral artery and the arterial pressure curve. A t test for matched pairs was used for statistical analysis (P < 0.05).


RESULTS
During stable mean arterial pressure and cardiac index, reduction of the arterial carbon dioxide partial pressure led to a significant increase of the capillary closing pressure from 25 +/- 11 mmHg to 39 +/- 15 mmHg (P < 0.001), with a consecutive decrease of blood flow velocity in the middle cerebral artery of 21.8 +/- 4.8%/kPa (P < 0.001), of cerebral blood flow from 64 +/- 29 ml/100 g/min to 39 +/- 15 ml/100 g/min (P < 0.001) and of jugular venous oxygen saturation from 75 +/- 8% to 67 +/- 14% (P < 0.01).


CONCLUSIONS
In contrast to other experimental and clinical data, we observed no pathological findings in the investigated parameters of cerebral perfusion and oxygenation.
Thees
Christof
C
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, 53105 Bonn, Germany. christof.thees@ukb.uni-bonn.de
Kaiser
Markus
M
Scholz
Martin
M
Semmler
Alexander
A
Heneka
Michael T
MT
Baumgarten
Georg
G
Hoeft
Andreas
A
Putensen
Christian
C
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001784:Blood Gas Analysis / Q000379:methods; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012121:Respiration, Artificial / Q000379:methods; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000503:physiopathology*
D002245:Carbon Dioxide