Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection.
In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.
Vexler
Albert
A
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, U.S.A.|Department of Biostatistics, The State University of New York, Farber Hall, Buffalo, New York 14214, U.S.A.
Liu
Aiyi
A
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, U.S.A.
Eliseeva
Ekaterina
E
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, U.S.A.|The University of Chicago, Chicago, Illinois, U.S.A.
Schisterman
Enrique F
EF
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, U.S.A.
D015415:Biomarkers / Q000032:analysis*; D001699:Biometry / Q000379:methods; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis; D006801:Humans; D007360:Intelligence / Q000502:physiology; D016209:Interleukin-8 / Q000032:analysis; D016013:Likelihood Functions; D015233:Models, Statistical; D009010:Monte Carlo Method; D012372:ROC Curve
D015415:Biomarkers; C508606:CXCL8 protein, human; D008076:Cholesterol, HDL; D016209:Interleukin-8; D002784:Cholesterol