Drosophila aging 2006/2007.
Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.
Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA. shawp@pcg.wustl.edu
Paul
P
Shaw
Karen
K
Ocorr
Rolf
R
Bodmer
Sean
S
Oldham
D000375:Aging / Q000502:physiology*; D000818:Animals; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism; D005260:Female; D008136:Longevity / Q000502:physiology; D008297:Male; D023421:Models, Animal; D018384:Oxidative Stress; D012098:Reproduction / Q000502:physiology; D012890:Sleep / Q000502:physiology
D029721:Drosophila Proteins