Expression of MIG-6, WNT-9A, and WNT-7B during osteoarthritis.
Although the molecular mechanisms for initiation of cartilage destruction in osteoarthritis (OA) are unknown, it has been demonstrated that disruption of mitogen-inducible gene 6 (Mig-6) in mice leads to the onset of a degenerative joint disease like OA. On this basis, we correlated gene expression of Mig-6 with Wnt-9a and Wnt-7b genes; we showed downregulation of Mig-6, Wnt-7b, and Wnt-9a during OA, while Wnt-7b was expressed also in osteoblast-like cells. Here we suggest that Aggrecan degradation occurs before the downregulation of Mig-6. It remains to be proven whether there is any relation between Wnt signaling and Aggrecan degradation.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Ciudad Universitaria, México DF, México.
Cristina
C
Velasquillo
David
D
Garciadiego-Cázares
Maylin
M
Almonte
Marcia
M
Bustamante
Clemente
C
Ibarra
Juan B
JB
Kouri
Jesús
J
Chimal-Monroy
D053674:Aggrecans / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis*; D002356:Cartilage / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D019902:Chondrocytes / Q000378:metabolism; D005786:Gene Expression Regulation; D017403:In Situ Hybridization; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008954:Models, Biological; D010003:Osteoarthritis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D051153:Wnt Proteins / Q000096:biosynthesis*
D053674:Aggrecans; D002352:Carrier Proteins; C000629925:Errfi1 protein, rat; D047908:Intracellular Signaling Peptides and Proteins; D051153:Wnt Proteins; C526250:Wnt9a protein, rat