Fat mass accumulation during childhood determines insulin sensitivity in early adulthood.
OBJECTIVE
Low birth weight and postnatal catch-up growth have been associated with an increased risk for diabetes mellitus type II (DMII). We evaluated the contribution of birth and adult size, body composition, and waist-to-hip ratio to DMII risk factors in young adulthood.


METHODS
In a group of 136 young adults, aged 18-24 yr, insulin sensitivity and disposition index were determined by frequent sampling iv glucose tolerance test. The association of clinical parameters with these variables was analyzed with multiple regression modeling. In addition, differences in insulin sensitivity and disposition index, a measure for beta-cell function, were analyzed in four subgroups, young adults either born small for gestational age SGA with short stature (n = 25) or SGA with catch-up growth (n = 23) or born appropriate for gestational age with idiopathic short stature (n = 23) or with normal stature (controls) (n = 26).


RESULTS
Fat mass was the only significant predictor of insulin sensitivity, whereas birth length and birth weight were not significant. After correction for age, gender, and adult body size, insulin sensitivity was significantly lower in subjects born SGA with catch-up growth compared with controls. None of the variables had a significant influence on disposition index, and there was no significant difference in disposition index between the subgroups.


CONCLUSIONS
Our data show that a higher body fat mass at 21 yr is associated with reduced insulin sensitivity, independent of birth size. These findings have important implications for public health practice.
Leunissen
R W J
RW
Department of Paediatrics, Division of Endocrinology, Erasmus Medical Centre-Sophia, Children's Hospital, 3015 GJ Rotterdam, The Netherlands. r.leunissen@erasmusmc.nl
Oosterbeek
P
P
Hol
L K M
LK
Hellingman
A A
AA
Stijnen
T
T
Hokken-Koelega
A C S
AC
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001827:Body Height; D001835:Body Weight / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology*; D016014:Linear Models; D008297:Male; D049629:Waist-Hip Ratio
D001786:Blood Glucose