Ischemic colitis as a complication in a patient with steroid-dependent nephrotic syndrome.
We report the case of a 16-year-old male patient with steroid-dependent nephrotic syndrome who developed ischemic colitis. He was diagnosed as having nephrotic syndrome at 10 years of age and had been administered steroid, cyclosporine A, and mizoribine for 7 years. He presented with severe abdominal pain 5 days after intravenous methylprednisolone pulse therapy; thereafter, massive bloody diarrhea developed. Abdominal ultrasonography and computed tomography revealed a marked thickening of the wall of the transverse colon. Colonoscopy confirmed the diagnosis of ischemic colitis. This is the first report of the development of ischemic colitis in a pediatric patient with nephrotic syndrome.
Department of Pediatrics, Ohta Nishinouchi Hospital, Fukushima, Japan.
Atsuhiro
A
Yanagisawa
Yoshiyuki
Y
Namai
Takashi
T
Sekine
Takashi
T
Igarashi
D000293:Adolescent; D017091:Colitis, Ischemic / Q000175:diagnosis / Q000209:etiology*; D003106:Colon / Q000000981:diagnostic imaging / Q000473:pathology; D003113:Colonoscopy; D016572:Cyclosporine / Q000627:therapeutic use; D003967:Diarrhea; D004359:Drug Therapy, Combination; D006471:Gastrointestinal Hemorrhage; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D020551:Pulse Therapy, Drug; D011859:Radiography; D014463:Ultrasonography
D005938:Glucocorticoids; D016572:Cyclosporine; D008775:Methylprednisolone