[Molecular phylogeny and genetic variability of echovirus 30 based on the analysis of the 3' end of the VP1 gene].
Echovirus 30 represent one of the most frequently isolated enterovirus serotype, incriminated in various pathologies, essentially aseptic meningitis. Several works studied the molecular epidemiology of these viruses. By analysing a region of 260 nucleotides situated in the end of the VP1 gene (region regrouping the majority of the sequences of the Echovirus 30), we proposed to realise a synthesis work which regroup the main epidemiological studies on the Echovirus 30. We established a phylogenetic profile of 87 Echovirus strains geographically distinct and isolated during a half a century (1957-2003). The phylogentic tree permitted to distinguish 2 genogroups which the nucleotide divergence exceeds 20%. The 2 genogroups also present internal subdivisions named genotypes which the nucleotide divergence is more than 15%. Finally, we noted phylogenetic regroupings within a same genotype. The general profile of the phylogenetic tree is characterised by a distribution of the Echovirus 30 strains in the time independently of their geographically isolation, which reveals a genetic evolution of these viruses related to their high genetic plasticity and the rapid circulation from a geographic area to another.
Laboratoire des maladies transmissibles et substances biologiquement actives (LAB-MDT-01), Faculté de pharmacie, Monastir, Tunisia. lamjed.bouslama@gmail.com
L
L
Bouslama
R
R
Harrath
H
H
Ben Othman
M
M
Aouni
D036022:Capsid Proteins / Q000235:genetics*; D004457:Echovirus Infections / Q000145:classification; D029822:Enterovirus B, Human / Q000145:classification / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008582:Meningitis, Aseptic / Q000821:virology; D010802:Phylogeny
D036022:Capsid Proteins