Ubiquitin-mediated signalling and Paget's disease of bone.
Multiple steps in the RANK-NF-kappaB signalling pathway are regulated by ubiquitylation. Mutations affecting different components of this pathway, including the ubiquitin binding p62 signalling adapter protein, are found in patients with Paget's disease of bone or related syndromes. Here, we review the molecular defects and potential disease mechanisms in these conditions and conclude that the mutations may confer a common increased sensitivity of osteoclasts to cytokines, resulting in disordered NF-kappaB-dependent osteoclast function. Modulation of the osteoclast RANK-NF-kappaB signalling axis may represent a viable therapeutic strategy for Paget's disease and other conditions where excessive bone resorption or remodelling is a feature. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK. robert.layfield@nottingham.ac.uk
Robert
R
Layfield
Barry
B
Shaw
D000818:Animals; D006801:Humans; D010001:Osteitis Deformans / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D025801:Ubiquitin / Q000235:genetics / Q000502:physiology*
D025801:Ubiquitin