An antiproliferative bis-prenylated quinone from the New Zealand brown alga Perithalia capillaris.
Bioactivity-directed isolation work on the endemic New Zealand brown alga Perithalia capillaris, seeking anti-inflammatory compounds, led to a new bis-prenylated quinone ( 4). This compound inhibited superoxide production by human neutrophils in vitro (IC 50 2.1 microM), but was more potent at inhibiting proliferation of HL60 cells (IC 50 0.34 microM). Two related bis-prenylated phenols were also isolated, one known ( 2) and one new ( 5), with weaker biological activities. This report extends the examples of bis-prenylated phenols as chemotaxonomic markers for brown algae of the order Sporochnales.
TerraMarine Pharmaceuticals, New Zealand Institute for Crop & Food Research Ltd, Chemistry Department, University of Otago, Dunedin, New Zealand.
Catherine E
CE
Sansom
Lesley
L
Larsen
Nigel B
NB
Perry
Michael V
MV
Berridge
Elizabeth W
EW
Chia
Jacquie L
JL
Harper
Victoria L
VL
Webb
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects*; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood
D000972:Antineoplastic Agents, Phytogenic; D011809:Quinones; D013481:Superoxides