Mutation-prone points in thrombin receptor.
BACKGROUND
Thrombin receptor (TR) is a G-protein-coupled receptor that transmits cellular responses to coagulant proteases in a variety of cell types in the vasculature and other tissues. Mutation within TR can be seen. Presently, the prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era.


METHODS
To identify the points vulnerable to mutation is a new trend directed at expanding the knowledge on disorders in genomic and proteomic levels of diseases. In this paper, the author performed a bioinformatics analysis to find the mutation-prone positions in the amino acid sequence of TR. To identify those points in TR, a new bioinformatics tool, namely, GlobPlot was used.


RESULTS
According to this work, no position was identified to be resistant to mutation.


CONCLUSIONS
This means that TR is a very highly genetically unstable molecule. Thousands of types of mutation can be expected. Of interest, only a few sense mutations are mentioned in clinical settings. Therefore, many occulted sense mutations might still be detected.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. wviroj@pioneer.netserv.chula.ac.th
D000595:Amino Acid Sequence; D019295:Computational Biology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D018179:Receptors, Thrombin / Q000737:chemistry* / Q000235:genetics*
D018179:Receptors, Thrombin