A phenanthrene modified RNA hairpin.
The influence of hairpin loop replacement with the phenanthrene moiety in RNA was investigated. The stability of this novel structure was compared to a hairpin with a U(4) loop, an extra stable tetra-loop (UUCG), and an analogous phenanthrene modified DNA hairpin. Thermal denaturation experiments and CD spectra were used to study the structure and stability of the modified hairpin.
Trkulja
Ivan
I
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Stutz
Alfred
A
Häner
Robert
R
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D006358:Hot Temperature; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D010616:Phenanthrenes / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry*; D020871:RNA Stability
D010616:Phenanthrenes; C031181:phenanthrene; D012313:RNA; D004247:DNA