5'-carbamoylphosphonyl-[6-3H]-AZT as a tool for studying metabolic transformations of the nonradioactive counterpart, an inhibitor of HIV replication.
An effective synthesis of 5'-carbamoylphosphonyl-[6-3H]-AZT was developed from [6-3H]-AZT. For the synthesized compound, chemical and enzymatic stability were determined and its penetration across HL-60 cell membranes was studied.
Yanvarev
Dmitry V
DV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. JDmitry@hotmail.com
Shirokova
Elena A
EA
Astapova
Maria V
MV
Shram
Vyacheslav I
VI
Kukhanova
Marina K
MK
Skoblov
Yury S
YS
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001711:Biotransformation; D004285:Dogs; D015195:Drug Design; D004355:Drug Stability; D018922:HL-60 Cells; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D011817:Rabbits; D014316:Tritium; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
D019380:Anti-HIV Agents; D014316:Tritium; D015215:Zidovudine