[Recent advances in the study of dendrimers-based drug delivery systems].
Dendrimers are hyperbranched, monodisperse and three dimensional macromolecules, which consist of an apolar core and polar shell have been referred to as "unimolecular micelles". This paper briefly describes the development and structural characteristics of dendrimers and also explains the feature of dendrimers as drug carrier and the dendrimer-drug interactions in details. Recently, dendrimers, which have attracted increasing attention for their applications in many fields such as drug targeted delivery systems and gene transfection, are becoming potential novel carriers.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Chang
C
Zheng
Ming-Xi
MX
Qiao
Lu
L
Yan
Hai-Yang
HY
Hu
Da-Wei
DW
Chen
D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D011073:Polyamines / Q000737:chemistry
D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines