Amino Acid derived enamides: synthesis and aminopeptidase activity.
Recently developed copper-catalyzed coupling methodology has been applied to the synthesis of amino acid derived enamides. Bond formation proved to be strongly influenced by protection strategy and vinyl iodide substitution while tolerant of limited side chain functionality. Assessment of aminopeptidase activity revealed a preference for (E)-1,2-disubstituted constructs.
Pharmaceutical Research and Development, Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts 01862, USA. richard.cesati@bms.com
Richard R
RR
Cesati
Greg
G
Dwyer
Reinaldo C
RC
Jones
Megan P
MP
Hayes
Padmaja
P
Yalamanchili
David S
DS
Casebier
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D000626:Aminopeptidases / Q000378:metabolism*
D000577:Amides; D000596:Amino Acids; D000626:Aminopeptidases