A nanoparticulate drug-delivery system for rivastigmine: physico-chemical and in vitro biological characterization.
The preparation and characterization of surface-PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi, 32-90123 Palermo, Italy. ema.craparo@unipa.it
Emanuela Fabiola
EF
Craparo
Giovanna
G
Pitarresi
Maria Luisa
ML
Bondì
Maria Pia
MP
Casaletto
Mariano
M
Licciardi
Gaetano
G
Giammona
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D048448:Phenylcarbamates / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D000068836:Rivastigmine; D014215:Triacetin; D014466:Ultraviolet Rays
D003692:Delayed-Action Preparations; C520606:PHM polymer; D010455:Peptides; D048448:Phenylcarbamates; D011109:Polymethacrylic Acids; D011092:Polyethylene Glycols; D000068836:Rivastigmine; D014215:Triacetin