The inflammatory cascade in acute pancreatitis: relevance to clinical disease.
Acute pancreatitis is an inflammatory condition that is initiated by the intra pancreatic activation of proteases. Pancreatic enzyme activation triggers a local and systemic inflammatory response that is associated with recruitment of inflammatory cells into the pancreas and a widespread up-regulation of inflammatory markers in distant tissues.
Elfar
Mohammed
M
Weill Cornell Medical College, Department of Surgery, The Methodist Hospital, 6550 Fannin Street, Suite SM1661A, Houston, TX 77030, USA.
Gaber
Lillian W
LW
Sabek
Omaima
O
Fischer
Craig P
CP
Gaber
A Osama
AO
D000208:Acute Disease; D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D042882:Gallstones / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000473:pathology / Q000503:physiopathology*; D011480:Protease Inhibitors / Q000627:therapeutic use
D011480:Protease Inhibitors