Hairpin mimics with phenanthroline- and bipyridine-derived linkers.
The synthesis and structural stabilities of modified oligonucleotide hairpins containing phenanthroline- and bipyridine-modified loops is reported. Phenanthroline (phen) and bipyridine (bipy) building blocks were synthesized, incorporated into DNA-oligonucleotides, and analyzed by thermal denaturation experiments. The so modified oligomers were found to form stable hairpin structures. Tm values were not affected by divalent transition metals.
Department of Chemistry, Biochemistry, University of Bern, Bern, Switzerland.
Gapian
G
Bianké
Robert
R
Häner
D015082:2,2'-Dipyridyl / Q000737:chemistry; D001483:Base Sequence; D002412:Cations; D015195:Drug Design; D008024:Ligands; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry
D002412:Cations; D008024:Ligands; D009841:Oligonucleotides; D010618:Phenanthrolines; D015082:2,2'-Dipyridyl