Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives.
A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 microg/mL.
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
Maloy
M
Kumar Parai
Gautam
G
Panda
Kumkum
K
Srivastava
Sunil
S
Kumar Puri
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001554:Benzene / Q000737:chemistry*; D015195:Drug Design; D007546:Isoquinolines / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000962:Antimalarials; D007546:Isoquinolines; D013449:Sulfonamides; D001554:Benzene