FIP200, a key signaling node to coordinately regulate various cellular processes.
A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
Boyi
B
Gan
Jun-Lin
JL
Guan
D000818:Animals; D000071183:Autophagy-Related Proteins; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D015870:Gene Expression; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D014176:Protein Biosynthesis; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D000071183:Autophagy-Related Proteins; D047908:Intracellular Signaling Peptides and Proteins; C407704:RB1CC1 protein, human; C428743:Rb1cc1 protein, mouse; D011505:Protein-Tyrosine Kinases