Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.
Propofol is a commonly used anesthetic agent, and it attenuates hypoxic ventilatory response in humans. Propofol reduce in vivo and in vitro carotid body responses to hypoxia as well as to nicotine in experimental animals. In the present study we examined the effects of propofol on carotid body responses to hypercapnia and K(+)-induced carotid body activation and compared these effects with hypoxia in an in vitro rabbit carotid body preparation. Hypoxia, hypercapnia and potassium increased the carotid sinus nerve activity and propofol attenuated the chemoreceptor responses to all three stimuli. However, the magnitude of propofol-induced attenuation was greater for hypercapnic and K(+)-induced carotid body activation compared to the hypoxic response. These observations suggest that propofol-induced attenuation of the hypoxic response is partly secondary to depression of chemoreceptor response to hypercapnia inhibiting the synergistic interactions between O(2) and CO(2) and may involve CO(2)/H(+) sensitive K(+) channels.
Department of Anesthesiology and Intensive Care Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Shingi
S
Akada
Malin Jonsson
MJ
Fagerlund
Sten G E
SG
Lindahl
Atsuhiro
A
Sakamoto
Nanduri R
NR
Prabhakar
Lars I
LI
Eriksson
D000200:Action Potentials / Q000187:drug effects; D000704:Analysis of Variance; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002344:Carotid Body / Q000187:drug effects* / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D006935:Hypercapnia / Q000473:pathology / Q000503:physiopathology; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology*; D011817:Rabbits
D018686:Anesthetics, Intravenous; D011188:Potassium; D015742:Propofol