Tryptamine derived amides with thiazole ring system from Thermoactinomyces strain TA66-2.
A moderately thermophilic actinomycete strain, which was identified as Thermoactinomyces strain TA66-2, was isolated from hot-spring water. Fermentation, followed by solvent partition and chromatographic separations, resulted in the isolation of two new and two known molecules. The structures of the new compounds were elucidated as 2-(1-Propionylaminoethyl)thiazole-4-carboxylic acid [2-(1H-indol-3-yl)ethyl]amide and 2-(1-Acetylaminoethyl)thiazole-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]amide by using spectral methods (1D-, 2D-NMR and LC-ESI-MS).
Science Technology Center (EBILTEM), Ege University, 35100 Bornova, Izmir, Turkey.
Cagla Akmemiş
CA
Korkmaz
E Esin
EE
Hameş-Kocabaş
Ataç
A
Uzel
Erdal
E
Bedir
D000577:Amides / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008848:Micromonosporaceae / Q000737:chemistry* / Q000235:genetics / Q000254:growth & development; D015394:Molecular Structure; D016133:Polymerase Chain Reaction; D021241:Spectrometry, Mass, Electrospray Ionization; D013844:Thiazoles / Q000302:isolation & purification*; D014363:Tryptamines / Q000737:chemistry*
D000577:Amides; D004269:DNA, Bacterial; D013844:Thiazoles; D014363:Tryptamines; C030820:tryptamine