The evolution of drug development in schizophrenia: past issues and future opportunities.
Schizophrenia is a disease syndrome with major public health implications. The primary advance in pharmacotherapeutics was in 1952 with the introduction of antipsychotic medications (ie, chlorpromazine, dopamine D2 antagonism). Barriers to progress have been substantial, but many will be subject to rapid change based on current knowledge. There are attractive psychopathology indications for drug discovery (eg, impaired cognition and negative symptoms), and drugs with efficacy in these domains may have application across a number of disease classes. These pathologies are observed prior to psychosis raising the possibility of very early intervention and secondary prevention. Success in drug discovery for cognition and negative symptom pathologies may bring forth issues in ethics as the potential for enhancing normal function is explored.
Carpenter
William T
WT
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. wcarpent@mprc.umaryland.edu
Koenig
James I
JI
D000818:Animals; D014150:Antipsychotic Agents / Q000266:history / Q000592:standards / Q000627:therapeutic use; D015195:Drug Design; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012106:Research / Q000266:history / Q000592:standards / Q000639:trends; D012559:Schizophrenia / Q000188:drug therapy* / Q000266:history / Q000503:physiopathology
D014150:Antipsychotic Agents