Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice.
The interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation were studied. Mice were induced with colitis and exposed to cigarette smoke (CS) and/or SC236 (a COX-2 inhibitor). Results indicated that CS did not alter acute colonic inflammation. Addition of SC236 abolished the induction of proliferation and oxidative damage by colitis. Chronic SC236 treatment abolished the promoting effect of CS on colonic adenoma formation, via suppression of COX-2- and VEGF-mediated proliferation and angiogenesis, and reversed bcl-2-mediated inhibition of apoptosis by CS. To conclude, COX-2 inhibitor could be an implication on cancer prevention in smokers with chronic colitis.
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Edgar Shiu-Lam
ES
Liu
Yi-Ni
YN
Ye
Vivian Yvonne
VY
Shin
William Ka-Kei
WK
Wu
Benjamin Chun-Yu
BC
Wong
Chi-Hin
CH
Cho
D000236:Adenoma / Q000209:etiology* / Q000517:prevention & control; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D003093:Colitis, Ulcerative / Q000150:complications*; D003110:Colonic Neoplasms / Q000209:etiology* / Q000517:prevention & control; D051546:Cyclooxygenase 2 / Q000502:physiology*; D016264:Dextran Sulfate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011720:Pyrazoles / Q000627:therapeutic use*; D012907:Smoking / Q000009:adverse effects*; D013449:Sulfonamides / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
D051546:Cyclooxygenase 2; D016264:Dextran Sulfate; D011720:Pyrazoles; D013449:Sulfonamides; C119130:4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; D000096926:Benzenesulfonamides