Long-term sustained mixed chimerism after allogeneic stem cell transplantation in a patient with severe aplastic anemia.
Mixed chimerism in a post-transplant patient with severe aplastic anemia (SAA) is generally considered to be a status preceding donor-cell rejection and bone marrow failure. Here, we report on a rare, prolonged mixed chimerism in a patient with SAA who showed a full recovery in hematological and immunological status after transplantation. The analysis in this patient showed about 20% and 80% recipient-type cells of total blood cells and T cells, respectively, at two years post-transplantation, and 14% and 25% of total blood cells and T cells, respectively, at four years post-transplantation. This report describes the most comprehensive case study known to date.
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Tokyo. amoriya-tky@umin.ac.jp
Akiko M
AM
Saito
Shigeru
S
Chiba
Seishi
S
Ogawa
Yoshinobu
Y
Kanda
Hisamaru
H
Hirai
Mineo
M
Kurokawa
D000293:Adolescent; D000741:Anemia, Aplastic / Q000235:genetics* / Q000601:surgery*; D016026:Bone Marrow Transplantation; D046528:Chimerism; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D013997:Time Factors; D014184:Transplantation, Homologous