Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.
Ly
Kiev S
KS
Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
Letavic
Michael A
MA
Keith
John M
JM
Miller
Jennifer M
JM
Stocking
Emily M
EM
Barbier
Ann J
AJ
Bonaventure
Pascal
P
Lord
Brian
B
Jiang
Xiaohui
X
Boggs
Jamin D
JD
Dvorak
Lisa
L
Miller
Kirsten L
KL
Nepomuceno
Diane
D
Wilson
Sandy J
SJ
Carruthers
Nicholas I
NI
D000577:Amides / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D054828:Histamine H3 Antagonists / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000577:Amides; D001381:Azepines; D054828:Histamine H3 Antagonists; D010879:Piperazines; D017367:Selective Serotonin Reuptake Inhibitors