The effect of tiotropium on the pulmonary diffusing capacity.
To our knowledge, there is no data on the effect of tiotropium on pulmonary gas exchange in healthy subjects. The aim of this study was to assess the effects of tiotropium on pulmonary diffusing capacity. Twenty-one healthy volunteers were enrolled for a prospective, randomized, double-blind, placebo-controlled study. Spirometric measurements, including pulmonary-diffusing capacity, were obtained before and after inhalation of drug or placebo. There was a significant decrease in forced vital capacity (FVC) and, consequently, an increase in the forced expiratory volume in one second (FEV1) to FVC ratio after placebo inhalation (p < 0.05), but no changes were found for percent-predicted FVC, FEV1, percent-predicted FEV1, percent-predicted forced expiratory flow (FEF25%-75%), percent-predicted peak expiratory flow (PEF), diffusing capacity of the lung for carbon monoxide (DLCO), single-breath alveolar volume (VA) and DLCO/VA ratio when compared with the baseline. Tiotropium inhalation caused a significant increase in FVC, percent-predicted FEV1, FEV1/FVC and percent-predicted FEF25%-75%, although the decrease in DLCO was insignificant (12.4 +/- 0.9 to 11.4 +/- 0.9). In conclusion, tiotropium does not change the pulmonary-diffusing capacity in healthy volunteers.
Department of Chest Diseases, Cumhuriyet University Medical School, Sivas, Turkey. gonlugur@gmail.com
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D000280:Administration, Inhalation; D000328:Adult; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002248:Carbon Monoxide / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000494:pharmacology*; D013147:Spirometry; D000069447:Tiotropium Bromide; D014797:Vital Capacity / Q000187:drug effects
D001993:Bronchodilator Agents; D012602:Scopolamine Derivatives; D002248:Carbon Monoxide; D000069447:Tiotropium Bromide