Organic solvent-free, enantio- and diastereoselective, direct Mannich reaction in the presence of water.
An organocatalyst-mediated, asymmetric Mannich reaction in the presence of water without using organic solvents has been developed. A highly reactive siloxytetrazole hybrid catalyst has been developed for the reaction of dimethoxyacetaldehyde, while the sodium salt of siloxyproline is an effective catalyst of alpha-imino glyoxylate. Excellent enantioselectivity can be realized, and the usage of organic solvents can be reduced compared to the conventional reactions in organic solvents.
Hayashi
Yujiro
Y
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
Urushima
Tatsuya
T
Aratake
Seiji
S
Okano
Tsubasa
T
Obi
Kazuki
K