Drosophila G9a is a nonessential gene.
Mammalian G9a is a euchromatic histone H3 lysine 9 (H3K9) methyltransferase essential for development. Here, we characterize the Drosophila homolog of G9a, dG9a. We generated a dG9a deletion allele by homologous recombination. Analysis of this allele revealed that, in contrast to recent findings, dG9a is not required for fly viability.
Department of Zoology and Animal Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.
Carole
C
Seum
Séverine
S
Bontron
Emanuela
E
Reo
Marion
M
Delattre
Pierre
P
Spierer
D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila / Q000201:enzymology* / Q000235:genetics* / Q000254:growth & development; D017353:Gene Deletion; D017344:Genes, Insect; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D007814:Larva / Q000201:enzymology / Q000254:growth & development; D009154:Mutation; D010641:Phenotype; D011496:Protein Methyltransferases; D011995:Recombination, Genetic
D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase