A global phenomenological model of ischemic stroke with stress on spreading depressions.
In this paper, we establish a new global phenomenological model of ischemic stroke. It takes into account local ischemia, energy reduction, propagation of spreading depressions (SD), damages to the cells and cellular death by apoptosis or necrosis. The spatial diffusion of the ions in the extracellular space which triggers the propagation of SD is a central point here. First we expose the various biological hypotheses that we have made in this model, and then we explain how to determine the parameters and solve the system of equations that we obtain. Next we present some results of this model: we simulate a KCl injection and then a local ischemia. Finally we discuss results and propose some improvements for this model.
Chapuisat
G
G
CMLA, ENS Cachan, CNRS, Pres UniverSud, 94235 Cachan, France. chapuisat@cmla.ens-cachan.fr
Dronne
M A
MA
Grenier
E
E
Hommel
M
M
Gilquin
H
H
Boissel
J P
JP
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000503:physiopathology*; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D013181:Cortical Spreading Depression; D006801:Humans; D008959:Models, Neurological; D020521:Stroke / Q000209:etiology / Q000503:physiopathology*