[Molecular and therapeutic approaches of the Alzheimer's disease].
The Alzheimer's disease (AD) is clinically characterized by the progressive appearance of amnesic disorders, which are followed by a clinical syndrome associating aphasia, apraxia and agnosia. In this picture are added behavioural problems, marked for example by decision-making or judgment confusions and disturbances of the orientation. The therapeutic perspectives are based especially on molecular targets that are the peptide Abeta, the protein tau or the facilitating molecular ways of neurodegeneration.
EA histologie et biologie du vieillissement, UF d'histologie, Pavillon Civiale, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France. jacques.hugon@lrb.aphp.fr
Jacques
J
Hugon
Claire
C
Paquet
D000375:Aging; D000377:Agnosia / Q000209:etiology; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D000647:Amnesia / Q000209:etiology; D001037:Aphasia / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D016875:tau Proteins
D016875:tau Proteins