DNA-TiO2 nanoconjugates labeled with magnetic resonance contrast agents.
Recent efforts have shown that nanoscale materials, specifically, metal-based nanoparticles, hold particular promise for the development of multifunctional imaging probes. These new materials provide the means to chaperone and concentrate both drugs and contrast agents in specific organs, tissues, and cells. Therefore, we have prepared a Gd(III)-modified DNA-TiO2 semiconducting nanoparticle that is detectable in cells by MR imaging. These labeled particles are retained at specific subcellular locations via DNA hybridization to intracellular targets, hence creating the first nanoparticle system capable of targeting specific DNA sequences while being simultaneously detected via MR imaging.
Endres
Paul J
PJ
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Paunesku
Tatjana
T
Vogt
Stefan
S
Meade
Thomas J
TJ
Woloschak
Gayle E
GE
D003287:Contrast Media / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles; D009693:Nucleic Acid Hybridization; D014025:Titanium / Q000737:chemistry*
D003287:Contrast Media; C009495:titanium dioxide; D004247:DNA; D005682:Gadolinium; D014025:Titanium