[Calcified aortal stenosis and osteoporosis: bone metabolism of systemic calcium metabolism in the elderly].
OBJECTIVE
To examine bone tissue, systemic calcium metabolism and bone remodeling in patients with calcified aortal stenosis of degenerative origin (DAS).


METHODS
The examination of 310 patients (mean age 73.2 years) was made with application of questioning, echocardiography, double energetic x-ray absorptionmetry, measurements of C-telopeptides, osteocalcin, vitamin D, parathyroid hormone with solid phase enzyme immunoassay.


RESULTS
Bone tissue mineral density (BTMD) was abnormal in 71% of examinees (osteopenia--40%, osteoporosis--31%). Vitamin D concentration under 50 nmol/l was in 76.3%, parathyroid hormone elevated above 100 pg/ml in 15.8% patients.


CONCLUSIONS
The severity of lumbar spine affection depended on severity of calcinosis of aortic valve, was associated with lowering of osteosynthetic activity and was not associated with the presence of osteoporosis risk factors, constitutional parameters, calcium metabolism changes. This suggests the existance of a special form of BTMD disorder in elderly patients with aortal stenosis.
N A
NA
Shostak
N Iu
NIu
Karpova
M A
MA
Rashid
T V
TV
Kazakova
D015502:Absorptiometry, Photon; D000368:Aged; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D012720:Severity of Illness Index; D014264:Tricuspid Valve Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism
D002118:Calcium