Glycolipids from the formosan soft coral Lobophytum crassum.
Three glycolipids (1--3), possessing a sugar moiety at C-2 of glycerol ether, have been isolated from the Formosan soft coral Lobophytum crassum. Their structures were elucidated by spectroscopic methods, particularly in 1D- and 2D-NMR experiments. The absolute configurations on the sugar portion and lipid aglycon of 1--3 were determined by methanolysis, chemical transformation and the application of Mosher's method on 1 and 3. Compounds 1--3 exhibited weak cytotoxic activities.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan ROC.
Chih-Hua
CH
Chao
Ho-Cheng
HC
Huang
Yang-Chang
YC
Wu
Chung-Kuang
CK
Lu
Chang-Feng
CF
Dai
Jyh-Horng
JH
Sheu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D013624:Taiwan
D000970:Antineoplastic Agents; D006017:Glycolipids; D007202:Indicators and Reagents