Retinal angiomatous proliferation reactivation 6 months after high-dose intravitreal acetonide triamcinolone and photodynamic therapy.
OBJECTIVE
To describe the incidence of retinal angiomatous proliferation (RAP) reactivation after combined treatment with a high-dose intravitreal triamcinolone acetonide (IVTA) and photodynamic therapy (PDT) at 1-year follow-up.


METHODS
All patients had undergone a full ophthalmic examination. High-dose IVTA (20 mg) was injected via pars plana. Four to 7 days later, PDT was delivered.


RESULTS
Fourteen eyes of 13 patients were included. Eight lesions (57%) reopened and needed retreatment with combined therapy at 6 months follow-up. At 1-year follow up, the lesion was obliterated in nine cases (64.2%) and best-corrected visual acuity improved from 0.87 logMar (range, 0.7-1) to 0.79 logMar (range, 0.5-1).


CONCLUSIONS
Combined therapy using high-dose IVTA and PDT is beneficial in stabilizing RAP. However, a high incidence of RAP reactivation has been observed at 6 months, even with a high-dose IVTA injection.
Hospital Clínico Universitario San Carlos, Madrid, Spain. rechejuan@yahoo.es
J
J
Reche-Frutos
C
C
Calvo-Gonzalez
J
J
Donate-Lopez
J
J
Garcia-Feijoo
F
F
Saenz-Frances
C
C
Fernandez-Perez
J
J
Garcia-Sanchez
D000798:Angiomatosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003131:Combined Modality Therapy; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D010778:Photochemotherapy; D011446:Prospective Studies; D012008:Recurrence; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D019233:Retreatment; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use; D014792:Visual Acuity
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide