C-H amination in synthesis: an approach to the assembly of the B/C/D ring system of aconitine.
A strategy for the preparation of aconitine is described that attempts to exploit chemoselective C-H amination and the electrophilic reactivity of oxathiazinane N,O-acetals for assembling the complex, polycyclic carbon framework of the natural product.
Conrad
Rosemary M
RM
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Du Bois
J
J
D000157:Aconitine / Q000737:chemistry*; D000586:Amination; D002244:Carbon / Q000737:chemistry*; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*
D002244:Carbon; D006859:Hydrogen; D000157:Aconitine