Influence of a platelet concentrate on prosthetic bone ingrowth in a rabbit model.
Recent studies have shown that an increase in bone ingrowth by addition of osteogenic growth factors can reduce micro motion and gross implant motion and contribute to joint implant stability through osseointegration. Platelet-rich plasma (PRP) has the potential to provide growth factors that may be conducive to osteointegration at the bone-implant interface. This study analyzed the influence of PRP on bone ingrowth upon a beaded metal implant in distal femurs of 22 rabbits. Rabbit limbs were randomly assigned to receive an implant plus PRP or plain implant. Half of the specimens were randomly assigned to a 2-week group (n = 20) or a 5-week group (n = 20). Histologic and histomorphometric comparison between implant alone and implant plus PRP, at 2 and 5 weeks, was performed. In both the 2- and 5-week comparisons, there was no statistical difference (p > .05) in bone ingrowth between the control and PRP group, despite a slight increase in trabecular bone growth in PRP groups. This study suggests that PRP is not a major contributing factor to bone ingrowth at the bone-implant interface. This supports growing evidence in the literature that PRP can lead to variable bone growth stimulation in vivo.
Department of Orthopaedics, Scott & White Hospital, 2401 South 31st Street, Temple, TX 76508, USA. cchaput@swmail.sw.org
Christopher D
CD
Chaput
Kushal V
KV
Patel
George W
GW
Brindley
Marc A
MA
Roux
Nianbin
N
Hu
Anton
A
Dmitriev
Bryan
B
Cunningham
D000497:Alloys / Q000737:chemistry; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D003094:Collagen; D005269:Femur / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D008852:Microradiography; D023421:Models, Animal; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D053657:Platelet-Rich Plasma; D019736:Prostheses and Implants; D011817:Rabbits; D011897:Random Allocation; D013499:Surface Properties; D013997:Time Factors
D000497:Alloys; D003094:Collagen