Microwave-assisted ribosylation of modified heterocyclic bases by Vorbrüggen method.
During the last decades the nucleoside synthesis has proven to be important. The modified silyl-Hilbert-Johnson nucleoside synthesis modified by Vorbrüggen is one of the most often used methods. We have studied N-glycosilation of modifieded heterocyclic bases by Vorbrüggen method with microwave irradiation and we were able to shorten the reaction time and obtain higher yields. The method was demonstrated by fluoroquinolone and purine.
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Nadja V
NV
Nikolaus
Jelena
J
Bozilović
Joachim W
JW
Engels
D006031:Glycosylation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D008722:Methods; D008872:Microwaves; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012266:Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D006571:Heterocyclic Compounds; D009705:Nucleosides; D012266:Ribose