New polyphenols active on beta-amyloid aggregation.
New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.
Rivière
Céline
C
Laboratoire de physique et biophysique, Institut des Sciences de Vigne et du Vin, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
Richard
Tristan
T
Vitrac
Xavier
X
Mérillon
Jean-Michel
JM
Valls
Josep
J
Monti
Jean-Pierre
JP
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000187:drug effects* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D013056:Spectrophotometry, Ultraviolet
D016229:Amyloid beta-Peptides; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols