Granulomatous reactions to permanent cosmetic tattoos successfully treated with topical steroids and allopurinol.
Two female patients presented nodular erythematous lesions overlying a permanent tattooed eyebrow and lip, respectively. Histologic examination showed in both cases epithelioid granulomas in close relation with scattered pigment. Complementary examinations and follow-up disclosed a sarcoidosis. The lesions resolved after treatment with topical steroids and also oral allopurinol in one of the cases. Allopurinol may be an effective treatment for granulomatous reactions to foreign body particles.
Martín
José M
JM
Department of Dermatology, Hospital Clinico Universitario, Valencia, Spain. jmmart@eresmas.com
Revert
Angeles
A
Monteagudo
Carlos
C
Villalón
Guillermo
G
Godoy
Rosa
R
Jordá
Esperanza
E
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use; D004396:Coloring Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005143:Eyelids / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D015745:Granuloma, Foreign-Body / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D008046:Lip / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013653:Tattooing / Q000009:adverse effects*
D004396:Coloring Agents; D016166:Free Radical Scavengers; D005938:Glucocorticoids; D000493:Allopurinol