Acute fatal post-CABG low dose amiodarone lung toxicity.
Amiodarone is one of the commonly used anti-arrhythmic agents with well-recognized chronic pulmonary toxicity. We present our experience of a patient with a fatal outcome after coronary artery bypass grafting and a short course of amiodarone treatment with a low total cumulative dose for the treatment of postoperative atrial fibrillation. Necropsy revealed diffuse pulmonary damage due to acute amiodarone lung toxicity.
Argyriou
Mihalis
M
Cardiac Surgery Department, Evaggelismos General Hospital, Veikou 9-11, 11146 Athens, Greece.
Hountis
Panagiotis
P
Antonopoulos
Nicolaos
N
Mathioudaki
Maria
M
D000208:Acute Disease; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000209:etiology; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007262:Infusions, Intravenous; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone