Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.
We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCC(ij)(0)) and their z-transforms (z(ij)(0)) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of z(ij)(0) successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sjögren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.
Georgopoulos
Apostolos P
AP
Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. omega@umn.edu
Karageorgiou
Elissaios
E
Leuthold
Arthur C
AC
Lewis
Scott M
SM
Lynch
Joshua K
JK
Alonso
Aurelio A
AA
Aslam
Zaheer
Z
Carpenter
Adam F
AF
Georgopoulos
Angeliki
A
Hemmy
Laura S
LS
Koutlas
Ioannis G
IG
Langheim
Frederick J P
FJ
McCarten
J Riley
JR
McPherson
Susan E
SE
Pardo
José V
JV
Pardo
Patricia J
PJ
Parry
Gareth J
GJ
Rottunda
Susan J
SJ
Segal
Barbara M
BM
Sponheim
Scott R
SR
Stanwyck
John J
JJ
Stephane
Massoud
M
Westermeyer
Joseph J
JJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001683:Biological Clocks; D001921:Brain / Q000503:physiopathology*; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D002648:Child; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*