Stress distribution in a three dimensional, geometric alveolar sac under normal and emphysematous conditions.
Pulmonary emphysema is usually the result of chronic exposure to cigarette smoke in at risk individuals. To investigate the hypothesis that lung damage in emphysema results from coincident weakening in the structural properties of the tissue and increased mechanical forces--as one explanation of the continued development of pulmonary emphysema after smoking cessation--we developed a three dimensional, geometric dodecahedron-based acinar model. Using the model numerical analysis of the stress distribution in normal conditions could be compared with those resulting in emphysematous conditions. Finite element analysis was used to evaluate the model at a number of lung inflation levels, using quasi-static loading of the alveolar pressure. When internal alveolar pressure was increased along with the adjustment of the material properties to represent a weakening of one wall in the acinus, increased stress resulted at the perimeters of the weakened area. In particular this increased stress was localized at the junction points of the internal alveolar septa. It was also found that under the proposed simulated emphysematous conditions, a significant disruption in the stress distribution within the acinus model occurred at low, rather than high, lung volumes. This is supportive of the physiological observation that destruction of the diseased tissue can occur under less stress than those existing in the normal state.
de Ryk
Jessica
J
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Thiesse
Jacqueline
J
Namati
Eman
E
McLennan
Geoffrey
G
D001696:Biomechanical Phenomena; D020342:Finite Element Analysis; D006801:Humans; D008953:Models, Anatomic; D011312:Pressure; D011650:Pulmonary Alveoli / Q000473:pathology* / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000473:pathology* / Q000503:physiopathology; D013314:Stress, Mechanical