Prevalence of bone mineral disease among adolescents with cystic fibrosis.
OBJECTIVE
To evaluate the prevalence of bone mineral disease among adolescents with cystic fibrosis and to relate the findings with the variables studied.


METHODS
The study enrolled 37 adolescents who were assessed for: nutritional status according to height/age and body mass/age ratios; bone mineral density of the lumbar spine and entire body by densitometry with dual emission X-ray; daily dietary intake according to a 3-day dietary recall; and pulmonary function by the forced expiratory volume in one second test.


RESULTS
Mean age was 13.2 (+/-2.8) years. Nutritional status was adequate in 70.3 and 75.7% of patients according to the height/age and body mass/age indices, respectively; 54.1% of the patients exhibited reduced lumbar spine bone mineral density and 32.5% for the whole body. There was a positive correlation between bone mineral density and body mass index (p = 0.04). Lung disease and pancreatic insufficiency exhibited a correlation with altered bone mineral density. The dietary recall revealed adequate percentages of calcium, phosphorous and calories, according to the nutritional recommendations laid out in the European Cystic Fibrosis Consensus. The multivariate analysis indicated that these variables were not statistically significant.


CONCLUSIONS
There is a high prevalence of bone mineral disease among adolescents. Good nutritional status, pancreatic enzyme replacement and control of lung disease may have a protective effect on bone mass.
Instituto Fernandes Figueira, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil. reinaldojacaldeira@yahoo.com.br
Reinaldo José do Amaral
RJ
Caldeira
Vânia de Matos
Vde M
Fonseca
Saint Clair Dos Santos
SC
Gomes
Célia Regina Moutinho de Miranda
CR
Chaves
D015502:Absorptiometry, Photon; D000293:Adolescent; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D009752:Nutritional Status; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011877:Radionuclide Imaging; D013147:Spirometry