Preparation of novel beta-cyclodextrin chiral stationary phase based on click chemistry.
A facile strategy based on click chemistry for preparation of the structurally well-defined native beta-cyclodextrin (beta-CD) based chiral stationary phase (CSP) was proposed. The beta-CD CSP was evaluated by enatioseparation of benzoin, trans-stilbene oxide, Troger's base, bendroflumethiazide, ketoprofen, chlorthalidone, three flavanone compounds and two beta-adrenergic blocking agents under reversed phase high performance liquid chromatography. The chromatographic results demonstrate the chiral separation ability of click beta-CD CSP and illustrate the usefulness of click chemistry in the preparation of beta-CD based CSP.
Zhang
Yongping
Y
School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Guo
Zhimou
Z
Ye
Jinxing
J
Xu
Qing
Q
Liang
Xinmiao
X
Lei
Aiwen
A
D001573:Benzoin / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism; D013267:Stilbenes / Q000302:isolation & purification; D047392:beta-Cyclodextrins / Q000138:chemical synthesis*
D013267:Stilbenes; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; C025906:stilbene oxide; D001573:Benzoin