Reversible switching of substrate activity of poly-N-isopropylacrylamide peptide conjugates.
The activity of smart polymer peptide conjugates towards chymotrypsin catalyzed hydrolysis was reversibly switched on and off using temperature as the trigger.
Organic Chemistry Department, Westfälische Wilhelms-Universität, Corrensstrasse 40, Münster, Germany.
Kian
K
Molawi
Armido
A
Studer
D000180:Acrylic Resins / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry*; D006868:Hydrolysis; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013696:Temperature
D000180:Acrylic Resins; D000588:Amines; D010455:Peptides; C052970:poly-N-isopropylacrylamide; D002918:Chymotrypsin