Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives.
Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D.
Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers F-49100, France.
Enguerran
E
Vanquelef
Jean-Jacques
JJ
Hélesbeux
Olivier
O
Duval
Eric
E
Debiton
Chantal
C
Barthomeuf
Christian
C
Jarry
Isabelle
I
Forfar
Pascal
P
Richomme
D000230:Adenocarcinoma / Q000188:drug therapy*; D000470:Alkaloids / Q000737:chemistry* / Q000627:therapeutic use; D000728:Androgens / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053119:Benzophenanthridines; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D010617:Phenanthridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D000470:Alkaloids; D000728:Androgens; D000970:Antineoplastic Agents; D053119:Benzophenanthridines; D010617:Phenanthridines; C002066:fagaronine