Alpha-substituted organic peroxides: synthetic strategies for a biologically important class of gem-dihydroperoxide and perketal derivatives.
In this paper we review the recent developments in the synthesis of alpha-substituted hydroperoxides. Alpha-substituted hydroperoxides are interesting compounds due to their chemistry and bioactivity and as intermediates for the synthesis of other peroxides, of which cyclic peroxides are of major importance. Although the emphasis of this report will be on the derivatives of gem-dihydroperoxides, perketals, as well as the less studied nitrogen and sulfur derivatives, will also be covered.
Zmitek
Katja
K
Laboratory of Organic and Bioorganic Chemistry, Department of Physical and Organic Chemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.
Zupan
Marko
M
Iskra
Jernej
J
D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry; D010100:Oxygen / Q000378:metabolism; D010126:Ozone / Q000378:metabolism; D013457:Sulfur Compounds / Q000737:chemistry
D006571:Heterocyclic Compounds; D017672:Nitrogen Compounds; D013457:Sulfur Compounds; D010126:Ozone; D006861:Hydrogen Peroxide; D010100:Oxygen