Telomere length inheritance and aging.
Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of longevity in the human population. On the other hand, telomere shortening is also observed in the course of many aging-associated disorders but determining whether it is a cause or a consequence is not an easy task. Here, we review the most relevant experimental and descriptive data relating telomere length, as a quantitative trait, to aging and longevity.
Kappei
Dennis
D
Telomeres & Cancer Laboratory, UMR7147, Institut Curie-CNRS-UPMC, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Londoño-Vallejo
J Arturo
JA
D000375:Aging / Q000235:genetics*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D019871:Dyskeratosis Congenita / Q000235:genetics; D006801:Humans; D008136:Longevity / Q000235:genetics; D051379:Mice; D023421:Models, Animal; D019655:Quantitative Trait, Heritable; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016615:Telomere / Q000737:chemistry / Q000378:metabolism*; D014898:Werner Syndrome / Q000235:genetics