Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives.
Novel amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives were prepared from ethyl 4-phenylsulfonyl-2-(2'-phenylsulfonylethyl)-2-cyanobutyrate (1), ethyl 4-arylsulfonyl-3-aryl-2-cyanobutyrate (7) and ethyl 4-arylmethylsulfonyl-3-aryl-2-cyanobutyrate (8). The lead molecules have been tested for their antimicrobial activity and antioxidant property.
Padmavathi
Venkatapuram
V
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India. vkpuram2001@yahoo.com
Venkata Subbaiah
Dandu Rangayapalle Chinna
DR
Mahesh
Konda
K
Radha Lakshmi
Thunga
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds; D002855:Chromatography, Thin Layer; D003500:Cyclization; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009569:Nitric Oxide / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D007555:Isoxazoles; D010851:Picrates; D047069:Pyrazolones; D011744:Pyrimidinones; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl