Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes.
OBJECTIVE
This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM).


METHODS
Healthy women with PPROM were recruited and treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained from the opposite arm and concentrations determined with the use of high-pressure liquid chromatography. Nonlinear mixed-effects modeling was performed in nonlinear mixed effect (population) modeling.


RESULTS
The pharmacokinetics of 17 patients was described by a 3-compartment model. Clearance and volume of distribution at steady state were 22.8 L/h and 21.4 L/h, respectively, similar to values in nonpregnant individuals. There was little variability between patients. No relationship was observed between values of individual pharmacokinetic parameters and various covariates.


CONCLUSIONS
The pharmacokinetics of amoxicillin in pregnant patients with PPROM similar to nonpregnant individuals. Given the small interindividual variability in pharmacokinetics, no dose adjustments are required to account for differences between subjects under normal circumstances.
Department of Obstetrics and Gynecology, Medical Centre Haaglanden, Lijnbaan, the Hague, The Netherlands.
Anouk E
AE
Muller
Joost
J
DeJongh
Paul M
PM
Oostvogel
Rob A
RA
Voskuyl
P Joep
PJ
Dörr
Meindert
M
Danhof
Johan W
JW
Mouton
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis / Q000188:drug therapy*; D005865:Gestational Age; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D011256:Pregnancy Outcome; D012016:Reference Values; D018570:Risk Assessment
D000658:Amoxicillin