New phosphatidylserine receptors: clearance of apoptotic cells and more.
Phagocytes recognize apoptotic cells using cell surface receptors, and subsequently engulf these cells. In a recent issue of Nature, two papers reported the identification of novel phagocytic receptors that directly interact with apoptotic cell surface phosphatidylserine (PS). The studies provide new insights into the apoptotic cell clearance process and implicate PS receptors in additional signaling events.
Zhou
Zheng
Z
Department of Biochemistry, Room 322B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. zhengz@bcm.edu
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D010587:Phagocytosis; D010718:Phosphatidylserines / Q000276:immunology; D011956:Receptors, Cell Surface / Q000502:physiology*
D010718:Phosphatidylserines; D011956:Receptors, Cell Surface; C408123:phosphatidylserine receptor