Effects of diabetes on murine lipoproteins and vascular disease.
The creation of mouse models that recapitulate human diabetic cardiovascular disease remains a significant challenge. Part of the problem relates to the lack of a clear understanding of the human phenotype. Although improved insulin-treat of hyperglycemia reduces cardiovascular events in patients with type 1 diabetes, similar data are not available in type 2 diabetes. Moreover, whether human vascular disease is increased by hyperglycemia, defective insulin actions, or other factors is not known. Significant progress has been made in developing models of both type 1 and type 2 diabetes in mouse that can be used to study the relationship between hyperglycemia and atherosclerosis. This review describes mouse models that recapitulate specific aspects of diabetic dyslipidemia, hyperglycemia/insulin resistance, and diabetic vascular disease. Overall, the studies have clearly demonstrated that hyperlipidemia is a major driver of atherosclerotic vascular disease in the mouse. The effects of hyperglycemia and insulin resistance on murine atherosclerosis remain uncertain.
Department of Experimental Medicine, Merck Research Labs, Rahway, NJ 07065, USA. hayes_dansky@merck.com
Hayes M
HM
Dansky
Ira J
IJ
Goldberg
D000818:Animals; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D003925:Diabetic Angiopathies / Q000097:blood / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000235:genetics; D051379:Mice; D014652:Vascular Diseases / Q000097:blood* / Q000235:genetics
D008074:Lipoproteins