Coeliac disease: oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.
OBJECTIVE
Oral mucosal lesions may be markers of chronic gastrointestinal disorders, such as those causing malabsorption. Our objectives were to assess the prevalence of recurrent oral aphthous-like ulcers in coeliac disease patients living in the Mediterranean area, and to evaluate the impact of a gluten-free diet.


METHODS
A test group of 269 patients (age range 3-17 years) with coeliac disease confirmed both serologically and histologically was compared with a control group of 575 otherwise clinically healthy subjects for the presence, or a positive history of aphthous-like ulcers. Coeliac disease patients with aphthous-like ulcers were re-evaluated 1-year after starting a gluten-free diet.


RESULTS
Aphthous-like ulcers were found significantly more frequently in coeliac disease, in 22.7% (61/269) of patients with coeliac disease versus 7.1% (41/575) of controls (p=<0.0001; chi-square=41.687; odds ratio=4.3123; 95% confidence interval=2.7664:6.722). Most coeliac disease patients with aphthous-like ulcers and adhering strictly to gluten-free diet (71.7%; 33/46) reported significant improvement on gluten-free diet, with no or reduced episodes of aphthous-like ulcers (p=0.0003; chi-square=13.101; odds ratio=24.67; 95% confidence interval=2.63:231.441).


CONCLUSIONS
The epidemiological association found between coeliac disease and aphthous-like ulcers suggests that recurrent aphthous-like ulcers should be considered a risk indicator for coeliac disease, and that gluten-free diet leads to ulcer amelioration.
Campisi
G
G
Department of Oral Sciences, University Hospital of Palermo, Palermo, Italy.
Di Liberto
C
C
Carroccio
A
A
Compilato
D
D
Iacono
G
G
Procaccini
M
M
Di Fede
G
G
Lo Muzio
L
L
Craxi
A
A
Catassi
C
C
Scully
C
C
D000293:Adolescent; D016022:Case-Control Studies; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D005983:Glutens / Q000008:administration & dosage*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D019226:Oral Ulcer / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012008:Recurrence; D018570:Risk Assessment; D016896:Treatment Outcome
D005983:Glutens