Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects.
Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
Wu
Tian-Shung
TS
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan. tswu@mail.ncku.edu.tw
Chern
Huei-Jen
HJ
Damu
Amooru Gangaiah
AG
Kuo
Ping-Chung
PC
Su
Chung-Ren
CR
Lee
E-Jian
EJ
Teng
Chi-Ming
CM
D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*
D004224:Diterpenes; D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors