A framework for tailoring clinical guidelines to comorbidity at the point of care.
BACKGROUND
Evidence is accumulating to suggest that clinical guidelines should be modified for patients with comorbidities, yet there is no quantitative and objective approach that considers benefits together with risks.


METHODS
We outline a framework using a payoff time, which we define as the minimum elapsed time until the cumulative incremental benefits of a guideline exceed its cumulative incremental harms. If the payoff time of a guideline exceeds a patient's comorbidity-adjusted life expectancy, then the guideline is unlikely to offer a benefit and should be modified. We illustrate the framework by applying this method to colorectal cancer screening guidelines for 50-year-old men with human immunodeficiency virus (HIV) and 60-year-old women with congestive heart failure (CHF).


RESULTS
We estimated that colorectal cancer screening payoff times for 50-year-old men with HIV would range from 1.9 to 5.0 years and that colorectal cancer screening payoff times for 60-year-old women with CHF would range from 0.7 to 2.9 years. Because the payoff times for 50-year-old men with HIV were lower than their life expectancies (12.5-24.0 years), colorectal cancer screening may be beneficial for these patients. In contrast, because payoff times for 60-year-old women with CHF were sometimes greater than their life expectancies (0.6 to >5 years), colorectal cancer screening is likely to be harmful for some of these patients.


CONCLUSIONS
Use of a payoff time calculation may be a feasible framework to tailor clinical guidelines to the comorbidity profiles of individual patients.
Braithwaite
R Scott
RS
Section of General Internal Medicine, Yale University School of Medicine, West Haven Veterans Affairs Connecticut Healthcare System, VACS 11 ACSL-G, 950 Campbell Ave, West Haven, CT 06516, USA. Ronald.braithwaite@va.gov
Concato
John
J
Chang
Chung Chou
CC
Roberts
Mark S
MS
Justice
Amy C
AC
D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D017408:Guidelines as Topic; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D019095:Point-of-Care Systems / Q000706:statistics & numerical data*; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors