Worry facilitates corticospinal motor response to transcranial magnetic stimulation.
Like other forms of emotion, anxiety has been theoretically linked to preparation for action. Worry is a type of anticipatory anxiety and the hallmark of generalized anxiety disorder. Research has shown that worry is associated with vigilance to threat cues and increased muscle tension, which may in part be explained by motor facilitation that accompanies preparation for action. This study assessed corticospinal motor responses during worry using transcranial magnetic stimulation (TMS). Participants received TMS during a worry induction, during motor imagery, and during mental arithmetic, while electromyography and force were measured. TMS over the primary motor cortex elicited larger corticospinal motor responses during worry than mental arithmetic and smaller responses than motor imagery of maximum voluntary contraction of targeted muscles. These findings suggest that the association between worry and motor preparation cannot be explained by high cognitive load and provide further support for theoretical accounts emphasizing the role of action preparation in anxiety.
Pennsylvania State University, University Park, PA, USA. oathes@wisc.edu
Desmond J
DJ
Oathes
Jared M
JM
Bruce
Jack B
JB
Nitschke
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000523:psychology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D009129:Muscle Tonus; D011712:Pyramidal Tracts / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult