Pharyngeal swallowing: defining pharyngeal and upper esophageal sphincter relationships in human neonates.
OBJECTIVE
To test the hypothesis that the sensorimotor characteristics of the reflexes evoked on stimulation with air and water infusions differ by studying the effect of pharyngeal stimulation on pharyngeal-upper esophageal sphincter (UES) interactions in healthy neonates.


METHODS
Pharyngo-UES-esophageal manometry was recorded in 10 neonates at 39 +/- 4 weeks postmenstrual age. Pharyngeal infusions (n = 155) of air (0.1 to 2.0 mL) and sterile water (0.1 to 0.5 mL) were given. Two types of reflexes were recognized: pharyngeal reflexive swallowing (PRS) and pharyngo-UES-contractile reflex (PUCR). Frequency occurrence, distribution of reflexes, threshold volume, response time, and stimulus-response relationship were evaluated.


RESULTS
The reflex response rates were 30% for air and 76% for water (P < .001). PRS was more frequent than PUCR with air and water (P < .05), even though the stimulation thresholds and response latencies were similar. Graded volumes of water but not air resulted in an increased frequency of PRS (P < .01).


CONCLUSIONS
PRS is more frequent than PUCR, and the 2 reflexes have distinctive characteristics in air and water stimuli. Both PRS and PUCR have implications for the evaluation of swallowing in infants.
Section of Neonatology, Columbus Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA. jadcherlas@pediatrics.ohio-state.edu
Sudarshan Rao
SR
Jadcherla
Alankar
A
Gupta
Erin
E
Stoner
Soledad
S
Fernandez
Reza
R
Shaker
D003679:Deglutition / Q000502:physiology*; D049631:Esophageal Sphincter, Upper / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D008365:Manometry; D010614:Pharynx / Q000502:physiology*; D010812:Physical Stimulation; D012018:Reflex / Q000502:physiology*