[Cardiotoxicity of n-methyl-glucamine antimoniate (Glucantime). A case report].
The pentavalent antimonial meglumine (Glucantime) is the drug of choice in treatment of cutaneous leishmaniasis in Tunisia. It may create severe adverse effects. A ten year-old girl was treated by Glucantime for cutaneous leishmaniasis. On the eighth day of treatment, she developed palpitations and precordialgia. The ECG showed T wave inversion prolongation of corrected QT interval. Drug therapy was stopped. Within a few days, she recovered and her elctrocardiographic changes came back to normal. The cardio toxicity of Glucantime may be severe. Electrocardiographic changes are the primary signs. Long term ECG follow-up is necessary.
Service de pédiatrie-urgences-consultations, hôpital d'enfants de Tunis, 1007, rue Jabbari, Bab-Saâdoun, Tunisie. nadia.matoussi@rns.tn
N
N
Matoussi
H B
HB
Ameur
S B
SB
Amor
Z
Z
Fitouri
S B
SB
Becher
D000981:Antiprotozoal Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D008536:Meglumine / Q000009:adverse effects*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects*
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate