Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A.
We report on a 3-year-old Melanesian girl admitted for acute renal failure following subfulminant hepatitis A virus infection. While the child was slowly recovering from severe cytolytic hepatitis, she presented 8 weeks of protracted fever and major eosinophilia (30,000/microl); thereafter, acute renal failure (serum creatinine 295 micromol/l) occurred. Renal histology displayed diffuse eosinophilic infiltrate, with severe acute tubulointerstitial lesions associated with mild glomerular endocapillary proliferation and eosinophilic infiltrate, suggesting an immunoallergic mechanism. The child had received cefixime and cotrimoxazole 3 weeks prior to hospitalisation for the hepatitis A virus infection. The final diagnosis was of the syndrome drug reaction with eosinophilia and systemic symptoms or DRESS, induced by cefixime or cotrimoxazole and possibly triggered by the hepatitis A virus infection.
Garnier
Arnaud
A
Pediatric Nephrology Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France. arnaud.garnier@rdb.aphp.fr
El Marabet
El Hachmi
el H
Kwon
Theresa
T
Peuchmaur
Michel
M
Mourier
Olivia
O
Baudouin
Véronique
V
Deschênes
Georges
G
Loirat
Chantal
C
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D020682:Cefixime / Q000009:adverse effects*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006506:Hepatitis A / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D013577:Syndrome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D020682:Cefixime