Lipoperoxidation and cyclooxygenase enzyme inhibitory piperidine alkaloids from Cassia spectabilis green fruits.
Phytochemical work in the search for bioactive metabolites from the methanolic extract of Senna spectabilis green fruits led to the isolation of a new piperidine alkaloid, (+)-3- O-feruloylcassine ( 1), in addition to the known (-)-spectaline ( 2) and (-)-3- O-acetylspectaline ( 3). The isolates were submitted to in vitro evaluation of lipoperoxidation (LPO) and cyclooxygenase enzymes (COX-1 and -2) inhibitory properties and showed moderate antioxidant activities (40-70%) at 100 ppm when compared to commercial standards BHT and vitamin E and moderate inhibition of COX-1 (ca . 40%) and marginal inhibition of COX-2 enzymes (<10%) at 100 ppm when compared to nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, rofecoxib, and celecoxib, respectively.
Instituto de Química, UNESP São Paulo State University, CP 355, CEP 14800-900, Araraquara, SP, Brazil.
Cláudio
C
Viegas
Dulce H S
DH
Silva
Marcos
M
Pivatto
Amanda
A
de Rezende
Ian
I
Castro-Gambôa
Vanderlan S
VS
Bolzani
Muraleedharan G
MG
Nair
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids; D016861:Cyclooxygenase Inhibitors; D010880:Piperidines