Diameter asymmetry of porcine coronary arterial trees: structural and functional implications.
The coronary vasculature is characterized by highly asymmetric diameters at bifurcations, which may be an important determinant of flow distribution. To facilitate accurate reconstruction of the coronary network for hemodynamic analysis, we introduce a statistical data set of the diameter asymmetry at bifurcations based on morphometric data of the porcine coronary arterial and venous trees. The bifurcation asymmetry data were represented by the diameter ratio of the daughters relative to mother vessel and by an area expansion ratio (AER) at each bifurcation. A novel asymmetry ratio matrix was introduced to describe the diameter asymmetry of daughters to mother vessels. The relations between AER and flow velocity, and asymmetry ratio matrix and flow distribution, were considered. The results indicate that the ratio of large daughter to mother vessel has a minimum value at order 5 (mean diameter of approximately 70 microm), whereas the ratio of small daughter to mother vessel decreases monotonically with increase in order number. The AER was found to be fairly uniform for larger vessels and to increase from order 5 toward the capillaries. At order 5, we observe a transition in asymmetric bifurcation pattern that may mark a hemodynamic transition from transmural to perfusion subnetworks. The functional implications of these structural transitions are considered.
Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Benjamin
B
Kaimovitz
Yunlong
Y
Huo
Yoram
Y
Lanir
Ghassan S
GS
Kassab
D000465:Algorithms; D000818:Animals; D002196:Capillaries / Q000033:anatomy & histology / Q000502:physiology; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D066298:In Vitro Techniques; D015233:Models, Statistical; D032389:Myocytes, Smooth Muscle / Q000145:classification / Q000502:physiology; D013552:Swine