Prediction of preeclampsia - a workshop report.
Understanding the mechanisms of disease responsible for the syndrome of preeclampsia as well as early risk assessment is still a major challenge. The concentrations of circulating proteins in maternal blood such as placental growth factor, soluble vascular endothelial growth factor receptor-1 and soluble endoglin are altered weeks before the onset of clinical symptoms of the syndrome. Recently, other proteins in maternal serum, such as activin A, inhibin A, PAPP-A, and PP13 have been suggested to be of value in first trimester risk assessment. Since preeclampsia is a syndrome, it seems unlikely that a single test will predict all forms of preeclampsia. This realization has led to the formulation of a new conceptual framework suggesting that a combination of markers (biochemical and/or biophysical) may be required to conduct comprehensive risk assessment for the syndrome.
First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. nthan@med.wayne.ed
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Romero
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Hillermann
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Cozzi
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Huppertz
D015415:Biomarkers; D004493:Education; D005260:Female; D005819:Genetic Markers; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors
D015415:Biomarkers; D005819:Genetic Markers