[Intracardial transplantation of mononuclear cells of the autologous bone marrow in complex treatment of patients with valvular heart diseases].
The authors present the first clinical experience with intramyocardial transplantation of the mononuclear fraction of cells of the autologous bone marrow in complex surgical treatment of 10 patients with valvular heart disease. The cellular transplantation was fulfilled intraoperatively when making a prosthetic mitral (5 patients) and aortal (5 patients) valves on the open heart under conditions of extracorporeal circulation. Simultaneously direct revascularization of the myocardium (aorto-coronary and mammary-coronary shunts) was performed in 4 patients (1--with a mitral and 3--with aortal heart diseases). An investigation of the results of the examination including ECG, EchoCG and investigation of the myocardium perfusion using one-photon emission computed tomography fulfilled in the early postoperative period and within 6-12 months after operation has shown that the cell cardiomyoplasty with mononuclear fraction of cells of the autologous bone marrow improves the myocardium perfusion, however, in the early postoperative period the appearance of transitory impairments of the heart rate is possible.
Davydenko
V V
VV
Gretsenko
V V
VV
Afanas'ev
B V
BV
Pizin
V M
VM
Mochalov
O Iu
OIu
Degtereva
O A
OA
Matiukov
A A
AA
D000328:Adult; D000787:Angina Pectoris / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D006349:Heart Valve Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014182:Transplantation, Autologous