Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Sub-chronic phencyclidine (PCP) treatment mimics certain aspects of schizophrenia symptomology in rats. However, there is a marked lack of attempts to model negative symptomology such as social behaviour deficits in female rats. This study was conducted to assess whether sub-chronic PCP treatment produces social interaction deficits in female rats and to ascertain if these deficits can be reversed by either typical (haloperidol) or atypical (clozapine and ziprasidone) antipsychotics.
The School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK.
Shikha
S
Snigdha
Joanna C
JC
Neill
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003024:Clozapine / Q000494:pharmacology; D004195:Disease Models, Animal; D004347:Drug Interactions; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D016555:Matched-Pair Analysis; D010622:Phencyclidine; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012559:Schizophrenia / Q000139:chemically induced / Q000150:complications; D012565:Schizophrenic Psychology; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D013844:Thiazoles / Q000494:pharmacology
D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone; D010622:Phencyclidine; D003024:Clozapine; D006220:Haloperidol