Evaluation of the inferior and superior laryngeal nerve stumps for perineural spread in laryngeal cancer.
OBJECTIVE
Perineural spread (PNS) is an important risk factor for locoregional failure and is correlated with reduced survival rates in squamous cell carcinoma of the larynx. PNS may extend proximally and/or distally in the nerve sheath by leaving uninvolved nerve segments. This method of extension may preclude obtaining tumor-free surgical margins, which may be responsible for recurrent disease. The purpose of this study is to investigate the presence or absence of PNS in extralaryngeal superior and inferior laryngeal nerves in patients who underwent total laryngectomy for squamous cell carcinoma of the larynx.


METHODS
Extralaryngeal segments of superior and inferior laryngeal nerves were resected bilaterally during 15 consecutive laryngectomies. Laryngectomy specimens and the harvested proximal nerve segments were histopathologically examined for the presence or absence of PNS.


RESULTS
Ten of 15 laryngectomy specimens showed PNS; however, none of the extralaryngeal superior or inferior laryngeal nerve segments revealed perineural involvement.


CONCLUSIONS
Extralaryngeal extension of PNS is highly unlikely in squamous cell carcinoma of the larynx.
Vural
Emre
E
Section of Otolaryngology-Head and Neck Surgery, Central Arkansas Veterans Healthcare System, John McClellan VA Hospital, Little Rock, AR, USA. vuralemrea@uams.edu
Fan
Chun-Yang
CY
Spring
Paul
P
Stack
Brendan C
BC
Kokoska
Mimi S
MS
Hanna
Ehab Y
EY
Suen
James Y
JY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007823:Laryngeal Nerves / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D012009:Recurrent Laryngeal Nerve / Q000473:pathology* / Q000601:surgery