In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.
We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.
Campus UFSM, Prédio 20, Sala 4139, 97105-900 Santa Maria, RS, Brazil. santurio@smail.ufsm.br.
Juliana S
JS
Argenta
Janio M
JM
Santurio
Sydney H
SH
Alves
Daniela I B
DI
Pereira
Ayrton S
AS
Cavalheiro
Andréia
A
Spanamberg
Laerte
L
Ferreiro
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001938:Brazil; D004283:Dog Diseases / Q000382:microbiology; D004285:Dogs; D004357:Drug Synergism; D006734:Horse Diseases / Q000382:microbiology; D006736:Horses; D007239:Infections / Q000382:microbiology / Q000662:veterinary; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009281:Naphthalenes / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D011775:Pythium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000077291:Terbinafine; D065819:Voriconazole