Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine.
A series of copper(II) and zinc(II) complexes involving a tridentate O,N,O'-donor Schiff base derived from salicylaldehyde and beta-alanine {i.e. N-salicylidene-beta-alanine(2-), (L)}, having the composition [Cu(2)(L)(2)(H(2)O)].H(2)O (1), [Cu(L)(H(2)O)](n) (2), and [Zn(L)(H(2)O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes 1 and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in the case of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.
Department of Chemical Drugs, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, CZ-612 42 Brno, Czech Republic.
Ján
J
Vanco
Jaromír
J
Marek
Zdenek
Z
Trávnícek
Eva
E
Racanská
Jan
J
Muselík
Ol'ga
O
Svajlenová
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D015032:Zinc / Q000737:chemistry*; D015091:beta-Alanine / Q000737:chemistry*
D000447:Aldehydes; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D015091:beta-Alanine; C013243:salicylaldehyde; D003300:Copper; D015032:Zinc