Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration.
The influence of subclinical nematodosis on the kinetic disposition of albendazole was evaluated in goats following oral and intraruminal administration. The disposition curves of its metabolites indicated increased uptake of the drug in parasitized goats following intraruminal compared to oral dosing (P < 0.05). The midpoint for the pharmacologically active metabolite, albendazole sulphoxide, in the circulatory compartment was around 0.6 mug ml- 1 both in parasitized and naïve goats. The period of exposure to this concentration was around 14 h (oral route), 18 h (intraruminal route) and 16 h (oral route), 17 h (intraruminal route) in parasitized and naïve goats, respectively. As the duration of exposure of parasites to the toxic concentration of the anthelmintically active metabolite was prolonged, it could be assumed that intraruminal delivery of the drug would improve the efficacy of albendazole in parasitized goats.
Dubey
A K
AK
Department of Parasitology College of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India.
Sanyal
P K
PK
Koley
K M
KM
Chaudhary
P L
PL
Mukherjee
K
K
Mandal
S C
SC
Pal
S
S
D000284:Administration, Oral; D015766:Albendazole / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000829:Animals, Domestic; D000969:Antinematodal Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D005243:Feces / Q000469:parasitology; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology; D006041:Goats; D006207:Half-Life; D009348:Nematoda / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy* / Q000662:veterinary*; D010270:Parasite Egg Count; D012417:Rumen
D000969:Antinematodal Agents; C027187:albendazole sulfone; D015766:Albendazole; C027186:albendazole sulfoxide