Endoscopic injection sclerotherapy with doxycycline for mediastinal and esophageal lymphangiohemangioma.
BACKGROUND
Lymphangiohemangioma, also called lymphatic-venous or venolymphatic malformation, is a rare malformation of the lymphatics, with vascular elements. These are low-flow vascular lesions.


OBJECTIVE
To evaluate the feasibility and efficacy of endoscopic injection sclerotherapy with doxycycline for low-flow vascular malformations in the GI tract.


METHODS
Case report.


METHODS
Academic center.


METHODS
An adult man with lymphangiohemangioma that involved the mediastinum and the esophagus. The esophageal involvement caused dysphagia and chest pain.


METHODS
We characterized the lesion with EUS and successfully treated the esophageal and paraesophageal lesions with endoscopic injection sclerotherapy by using doxycycline.


METHODS
Symptom resolution and complications.


RESULTS
The patient's esophageal symptoms resolved with sclerotherapy. This is the first reported case of lymphangiohemangioma with esophageal involvement and the first reported case of endoscopic injection sclerotherapy by using doxycycline in the GI tract.


CONCLUSIONS
Case report and short follow-up period.


CONCLUSIONS
Endoscopic injection sclerotherapy with doxycycline for lymphatic and low-flow vascular malformations in the GI tract is feasible, easy, safe, and effective.
Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390-9151, USA.
Shou-Jiang
SJ
Tang
Jayaprakash
J
Sreenarasimhaiah
Linda
L
Tang
Nancy
N
Rollins
Phillip D
PD
Purdy
D000328:Adult; D004318:Doxycycline / Q000627:therapeutic use*; D004945:Esophagoscopy; D004947:Esophagus / Q000000981:diagnostic imaging; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms; D012597:Sclerosing Solutions / Q000627:therapeutic use; D015911:Sclerotherapy; D014463:Ultrasonography
D012597:Sclerosing Solutions; D004318:Doxycycline