Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents.
Novel 2'-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Lee
Jeong A
JA
Kim
Hea Ok
HO
Tosh
Dilip K
DK
Moon
Hyung Ryong
HR
Lee
Seung-Jin
SJ
Lee
Kang Man
KM
Sheen
Yhun Y
YY
Chun
Moon Woo
MW
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D007202:Indicators and Reagents; D009705:Nucleosides