The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient.
P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.
Wang
Jun-Sheng
JS
Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA.
Newport
D Jeffrey
DJ
Stowe
Zachary N
ZN
Donovan
Jennifer L
JL
Pennell
Page B
PB
DeVane
C Lindsay
CL
D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000378:metabolism; D011619:Psychotropic Drugs / Q000378:metabolism / Q000627:therapeutic use*
D002352:Carrier Proteins; D011619:Psychotropic Drugs