The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China.
The frequency of lactase persistence varies widely in human populations. Study showed that the T allele of a C/T transition 13910bp upstream from exon 1 of lactase gene (LCT) was completely associated with lactase persistence in a Finnish population. To evaluate if the frequency of -13910T allele was in concordance with the lactase persistence in northern Chinese populations, in this study, we used Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) to detect the lactase -13910T allelic frequency in 5 northern Chinese populations for the first time. Results showed that the T allele frequency was low in these populations and that it did not match the lactase persistence phenotype in these populations. Therefore the -13910T allelic frequency can not serve as a predictor of the lactase persistence in these populations and this suggests the existence of other possible mechanisms of lactose tolerance in Chinese populations.
Laboratory of Medical Genetics, Harbin Medical University, PR, China.
Hai-Ming
HM
Sun
Yuan-Dong
YD
Qiao
Feng
F
Chen
Li-Dan
LD
Xu
Jing
J
Bai
Song-Bin
SB
Fu
D001483:Base Sequence; D002681:China; D005784:Gene Amplification; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D043322:Lactase / Q000235:genetics*; D007787:Lactose Intolerance / Q000235:genetics*; D008969:Molecular Sequence Data; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D043322:Lactase