The use of dexamethasone to reduce pain after tonsillectomy in adults: a double-blind prospective randomized trial.
OBJECTIVE
To determine the effectiveness of dexamethasone to reduce pain after tonsillectomy in adults by at least 13 mm on the visual analogue scale. The secondary objective was to reduce the use of narcotics by at least 20%.


METHODS
This multicentric study is a prospective double-blind randomized controlled trial.


METHODS
A total of 102 patients were enrolled and received a 4-day trial either of dexamethasone in decreasing doses or placebo. The patients were asked to note the level of pain on the visual analogue scale daily for 7 days. They also had to record their consumption of analgesic and any eventual side effects.


RESULTS
There were no statistically or clinically significant differences between the two groups for the level of pain noted on the visual analogue scale for the first 4 and 7 days. There were no statistical differences for the consumption of hydromorphone between the two groups.


CONCLUSIONS
We cannot recommend the use of dexamethasone on a routine basis following tonsillectomy in adults for the reduction of pain or narcotics consumption.
ENT Department, Le Centre Hospitalier Universitaire de Québec, Laval University, Quebec City, Quebec, Canada. mariannelachance@hotmail.com
Marianne
M
Lachance
Yolène
Y
Lacroix
Nathalie
N
Audet
Patrick
P
Savard
François
F
Thuot
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D014068:Tonsillectomy
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone