Molecular characterization of three new virulent Newcastle disease virus variants isolated in China.
Three cases of Newcastle disease virus (NDV) found in nature had the lentogenic motif (112)G-R-Q-G-R-L(117) in their fusion protein cleavage sites. However, both intracerebral pathogenicity and intravenous pathogenicity indexes showed that these NDV isolates were virulent. In comparison with the LaSota live virus vaccine, these viruses had significant genetic variations in the hemagglutinin-neuraminidase gene.
Tan
Lei-Tao
LT
Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Xu
Huai-Ying
HY
Wang
You-Ling
YL
Qin
Zhuo-Ming
ZM
Sun
Lei
L
Liu
Wen-Jun
WJ
Cui
Zhi-Zhong
ZZ
D020816:Amino Acid Motifs; D000818:Animals; D001717:Birds; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D015707:HN Protein / Q000235:genetics*; D008969:Molecular Sequence Data; D009521:Newcastle Disease / Q000453:epidemiology / Q000821:virology*; D009522:Newcastle disease virus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014760:Viral Fusion Proteins / Q000235:genetics*; D014774:Virulence
D015707:HN Protein; D014760:Viral Fusion Proteins