Coenzyme Q10 does not protect cochlear hair cells from death in the ischemic organotypic culture.
OBJECTIVE
To evaluate in vitro the effect of coenzyme Q10 (CoQ(10)) on ischemia-induced hair cell death.


METHODS
Organotypic cochlear cultures of newborn rats were subjected to ischemia with and without CoQ(10).


RESULTS
Addition of CoQ(10) has not prevented HC loss.


CONCLUSIONS
CoQ(10) seems to protect against only certain modes of cell death.
Khan
Martin
M
Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin, Germany.
Amarjargal
Nyamaa
N
Gross
Johann
J
Haupt
Heidemarie
H
Scherer
Hans
H
Mazurek
Birgit
B
D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003067:Coenzymes / Q000494:pharmacology; D045222:Electron Transport Chain Complex Proteins / Q000494:pharmacology*; D006198:Hair Cells, Auditory / Q000187:drug effects*; D007511:Ischemia / Q000503:physiopathology*; D009584:Nitrogen / Q000494:pharmacology; D009924:Organ Culture Techniques; D010498:Perilymph / Q000502:physiology; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D003067:Coenzymes; D045222:Electron Transport Chain Complex Proteins; D020011:Protective Agents; D014451:Ubiquinone; D002245:Carbon Dioxide; C024989:coenzyme Q10; D009584:Nitrogen