Exercise and MEF2-HDAC interactions.
Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5'-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.
Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Sean L
SL
McGee
D000818:Animals; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D018006:Myogenic Regulatory Factors / Q000235:genetics* / Q000378:metabolism*
D018006:Myogenic Regulatory Factors; D006655:Histone Deacetylases