Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma.
Much of the variation in inherited risk of glioma is likely to be explained by combinations of common low risk variants. The established relationship between glioma risk and exposure to ionizing radiation led us to examine whether variants in the DNA repair genes contribute to disease susceptibility. We evaluated 1127 haplotype-tagging single-nucleotide polymorphisms (SNPs) supplemented with 388 putative functional SNPs to capture most of the common variation in 136 DNA repair genes, in five unique case-control series from four different countries (1013 cases, 1016 controls). We identified 16 SNPs associated with glioma risk at the 1% significance level. The highest association observed across the five independent case-control datasets involved rs243356, which maps to intron 3 of CHAF1A (trend odds ratio, 1.32; 95% confidence interval 1.14-1.54; P = 0.0002; false-positive report probability = 0.055, based on a prior probability of 0.01). Our results provide additional support for the hypothesis that low penetrance variants contribute to the risk of developing glioma and suggest that a genetic variant located in or around the CHAF1A gene contributes to disease risk.
Bethke
Lara
L
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Rd, Sutton, Surrey SM2 5NG, UK.
Webb
Emily
E
Murray
Anne
A
Schoemaker
Minouk
M
Johansen
Christoffer
C
Christensen
Helle Collatz
HC
Muir
Kenneth
K
McKinney
Patricia
P
Hepworth
Sarah
S
Dimitropoulou
Polyxeni
P
Lophatananon
Artitaya
A
Feychting
Maria
M
Lönn
Stefan
S
Ahlbom
Anders
A
Malmer
Beatrice
B
Henriksson
Roger
R
Auvinen
Anssi
A
Kiuru
Anne
A
Salminen
Tiina
T
Swerdlow
Anthony
A
Houlston
Richard
R
D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide