Postpartum seizures after epidural analgesia: a patient with a mutation of the factor V Leiden and prothrombin gene.
We report the case of a 27-year-old parturient who developed a headache within 12 hours of delivery and who subsequently seized. Further examination, including magnetic resonance imaging and computed tomographic scan, showed a partial thrombosis of a transversal venous sinus, the underlying cause being an activated protein C resistance caused by a heterozygote factor V Leiden mutation and heterozygote prothrombin-gene mutation G20210A. Seven months after delivery, the patient is in good health, showing no neurocognitive disability.
Department of Anesthesiology, Academic Hospital Flemish Free University of Brussels, 1090, Brussels, Belgium. j.vannordennen@gmail.com
Johannes
J
van Nordennen
Frederic
F
Camu
D000328:Adult; D015360:Analgesia, Epidural / Q000009:adverse effects*; D016362:Analgesia, Obstetrical / Q000009:adverse effects*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006261:Headache / Q000209:etiology; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D009154:Mutation / Q000235:genetics* / Q000502:physiology*; D049590:Postpartum Period; D011247:Pregnancy; D011486:Protein C / Q000235:genetics / Q000502:physiology; D011516:Prothrombin / Q000235:genetics* / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced* / Q000235:genetics*; D014057:Tomography, X-Ray Computed
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin