Glioblastoma multiforme: the role of DSB repair between genotype and phenotype.
Glioblastoma is the most frequent primary brain tumor in adults. The average survival time of less than 1 year did not improve notably over the last three decades. The dismal prognosis of glioblastoma patients is largely due to the striking radioresistance of this tumor. Here, we attempt a combined view on the genetics, the repair mechanisms and the radioresistance of glioblastoma. Specifically, we address the role of DNA-PKcs and the novel potential end-joining factor KUB3 in maintaining the radioresistant phenotype, the interrelationship between genetic lesions and repair mechanisms, and new perspectives that emerge from the identification of glioblastoma stem cells.
Fischer
U
U
Department of Human Genetics, Saarland University, Homburg/Saar, Germany.
Meese
E
E
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics*; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D010641:Phenotype
D004273:DNA, Neoplasm