The effect of water and shampooing on the efficacy of a pyriprole 12.5% topical solution against brown dog tick (Rhipicephalus sanguineus) and cat flea (Ctenocephalides felis) infestations on dogs.
The efficacy of a single treatment with a 12.5% pyriprole spot-on formulation against induced infestations with R. sanguineus ticks and cat fleas (C. felis) as well as its persistence after repeated washing and shampooing was investigated in four separate studies. In a first study on R. sanguineus involving 32 beagle dogs, the efficacy at various time-points during the 30 days that followed treatment assessed 48 h after re-infestation ranged from 100% to 99.3%. No engorged ticks, alive or dead, were found in the treated animals. Shampooing 2 days after treatment and weekly washings did not affect the efficacy. In a second study on R. sanguineus involving 32 beagle dogs, the efficacy at various time-points during the 30 days that followed treatment assessed 48 h after re-infestation ranged from 100% to 96.8%. Single washing 8h after treatment and single shampooing 24 h after treatment had no negative impact on the efficacy of the product. In a third study on C. felis involving 28 beagle dogs, the efficacy at various time-points during the 30 days that followed treatment assessed 48 h after re-infestation was always 100% and weekly washings did not diminish the efficacy. In a last study on C. felis involving 24 beagle dogs, the efficacy at various time-points during the 5 weeks that followed treatment assessed 48 h after re-infestation ranged from 100% to 99.8%, and shampooing 24 h after treatment did not reduce the efficacy. The product was well tolerated by the dogs.
Novartis Animal Health Inc., Basel, Switzerland.
G
G
Schuele
S
S
Barnett
B
B
Bapst
T
T
Cavaliero
L
L
Luempert
G
G
Strehlau
D R
DR
Young
C
C
Moran
P
P
Junquera
D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000469:parasitology / Q000517:prevention & control; D004285:Dogs; D004478:Ectoparasitic Infestations / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007306:Insecticides; D008297:Male; D011897:Random Allocation; D048508:Rhipicephalus sanguineus; D005423:Siphonaptera; D012915:Soaps / Q000008:administration & dosage; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary; D013997:Time Factors; D014867:Water / Q000008:administration & dosage
D007306:Insecticides; D012915:Soaps; D014867:Water