Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy.
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a significant, debilitating symptom resulting from the administration of neurotoxic chemotherapy for the treatment of cancer. CIPN is an important consequence of cancer treatment because of its potential impact on physical functioning and quality of life. Oncology nurses play an important role in assessing, monitoring, and educating clients about CIPN. Despite investigations concerning pharmacologic and nonpharmacologic approaches to either preventing or minimizing the neurotoxicity resulting from certain chemotherapeutic agents, evidence to support the interventions is lacking. This article presents information concerning CIPN and summarizes the evidence for pharmacologic and nonpharmacologic approaches to the prevention and treatment of CIPN.
The College of Nursing, The University of Nebraska Medical Center, Omaha, NE, USA. cvisovsky@unmc.edu
Constance
C
Visovsky
Mary
M
Collins
Linda
L
Abbott
Julie
J
Aschenbrenner
Connie
C
Hart
D000108:Acetylcarnitine / Q000627:therapeutic use; D015670:Acupuncture Therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D002211:Capsaicin / Q000627:therapeutic use; D019317:Evidence-Based Medicine / Q000458:organization & administration*; D005081:Exercise Therapy; D005973:Glutamine / Q000627:therapeutic use; D005978:Glutathione / Q000627:therapeutic use; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use; D008274:Magnesium / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000451:nursing; D024802:Nurse's Role; D015399:Nursing Research / Q000458:organization & administration; D009859:Oncology Nursing / Q000458:organization & administration; D010353:Patient Education as Topic; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000628:therapy; D012107:Research Design; D018689:Sensory System Agents / Q000627:therapeutic use; D004561:Transcutaneous Electric Nerve Stimulation; D014810:Vitamin E / Q000627:therapeutic use
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D000970:Antineoplastic Agents; D000975:Antioxidants; D018689:Sensory System Agents; D005973:Glutamine; D014810:Vitamin E; D000108:Acetylcarnitine; D005978:Glutathione; D008274:Magnesium; D002211:Capsaicin; D002118:Calcium