Quantification of blood flow from rotational angiography.
For assessment of cerebrovascular diseases, it is beneficial to obtain three-dimensional (3D) information on vessel morphology and hemodynamics. Rotational angiography is routinely used to determine the 3D geometry and we propose a method to exploit the same acquisition to determine the blood flow waveform and the mean volumetric flow rate. The method uses a model of contrast agent dispersion to determine the flow parameters from the spatial and temporal development of the contrast agent concentration, represented by a flow map. Furthermore, it also overcomes artifacts due to the rotation of the c-arm using a newly introduced reliability map. The method was validated on images from a computer simulation and from a phantom experiment. With a mean error of 11.0% for the mean volumetric flow rate and 15.3% for the blood flow waveform from the phantom experiments, we conclude that the method has the potential to give quantitative estimates of blood flow parameters during cerebrovascular interventions.
Waechter
I
I
Centre for Medical Image Computing, Department of Medical Physics & Bioengineering, University College London, UK. I.Waechter@cs.ucl.ac.uk
Bredno
J
J
Barratt
D C
DC
Weese
J
J
Hawkes
D J
DJ
D000465:Algorithms; D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012399:Rotation; D012680:Sensitivity and Specificity