Automatic analysis of single-channel sleep EEG: validation in healthy individuals.
OBJECTIVE
To assess the performance of automatic sleep scoring software (ASEEGA) based on a single EEG channel comparatively with manual scoring (2 experts) of conventional full polysomnograms.


METHODS
Polysomnograms from 15 healthy individuals were scored by 2 independent experts using conventional R&K rules. The results were compared to those of ASEEGA scoring on an epoch-by-epoch basis.


METHODS
Sleep laboratory in the physiology department of a teaching hospital.


METHODS
Fifteen healthy volunteers.


RESULTS
The epoch-by-epoch comparison was based on classifying into 2 states (wake/sleep), 3 states (wake/REM/ NREM), 4 states (wake/REM/stages 1-2/SWS), or 5 states (wake/REM/ stage 1/stage 2/SWS). The obtained overall agreements, as quantified by the kappa coefficient, were 0.82, 0.81, 0.75, and 0.72, respectively. Furthermore, obtained agreements between ASEEGA and the expert consensual scoring were 96.0%, 92.1%, 84.9%, and 82.9%, respectively. Finally, when classifying into 5 states, the sensitivity and positive predictive value of ASEEGA regarding wakefulness were 82.5% and 89.7%, respectively. Similarly, sensitivity and positive predictive value regarding REM state were 83.0% and 89.1%.


CONCLUSIONS
Our results establish the face validity and convergent validity of ASEEGA for single-channel sleep analysis in healthy individuals. ASEEGA appears as a good candidate for diagnostic aid and automatic ambulant scoring.
Berthomier
Christian
C
PHYSIP SA, Paris, France. christian.berthomier@physip.fr
Drouot
Xavier
X
Herman-Stoïca
Maria
M
Berthomier
Pierre
P
Prado
Jacques
J
Bokar-Thire
Djibril
D
Benoit
Odile
O
Mattout
Jérémie
J
d'Ortho
Marie-Pia
MP
D000328:Adult; D004569:Electroencephalography; D004576:Electromyography; D001330:Electronic Data Processing; D004585:Electrooculography; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM; D011795:Surveys and Questionnaires; D014851:Wakefulness / Q000502:physiology