Factors associated with HIV viral load in a respondent driven sample in Los Angeles.
This study used a modified version of the Behavioral Model for Vulnerable Populations to examine the predisposing, enabling, and need factors associated with detectable viral load (VL). HIV status was measured using saliva and confirmed by blood. Of 797 persons enrolled, 193 were HIV positive and provided VL counts. A hierarchical multivariate logistic regression approach demonstrated that the predisposing factors of homelessness and recent substance abuse, particularly methamphetamine abuse, had a negative association with VL. The negative association of homelessness on VL was weakened with the introduction of enabling and need utilization factors. Mediation analysis indicated homelessness and HIV medication taking significantly associated with methamphetamine use as a predictor of detectable viral load. Guided policy to address substance abuse among those who are HIV positive is needed to improve biological outcomes.
Department of Family Medicine, David Geffen School of Medicine at University of California at Los Angeles (UCLA), 10880 Wilshire Blvd, Suite 540, Box 957087, Los Angeles, CA, 90095-7087, USA. wdking37@yahoo.com
William D
WD
King
Sherry
S
Larkins
Christopher
C
Hucks-Ortiz
Pin-Chieh
PC
Wang
Pamina M
PM
Gorbach
Rose
R
Veniegas
Steven
S
Shoptaw
D000328:Adult; D000367:Age Factors; D019969:Amphetamine-Related Disorders / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000523:psychology* / Q000821:virology; D006703:Ill-Housed Persons / Q000706:statistics & numerical data; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D016017:Odds Ratio; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology; D019562:Viral Load / Q000706:statistics & numerical data*