Steroid-responsive nephrotic syndrome in a child with juvenile idiopathic arthritis.
Renal disease is rare in children with juvenile idiopathic arthritis, although a number of associated nephropathies have been described, including mesangial glomerulonephritis. We report the presence of mesangial glomerulonephritis, revealed by a nephrotic syndrome, in a paediatric patient with juvenile idiopathic arthritis. Short-term steroid treatment induced a rapid remission of the nephrotic syndrome, but the presence of anti-nuclear antibodies, 1:320 in a homogeneous pattern, irregular deposits of C1q in a renal biopsy, and a mother with episodes of cutaneous lupus suggested an uncertain renal evolution for this infant.
Bandin
Flavio
F
Department of Paediatric Nephrology, Children's Hospital, Centre de Référence du Sud-Ouest des Maladies Rénales Rares, Toulouse, France. bandin.f@chu-toulouse.fr
Merhenberger
Marion
M
Modesto
Anne
A
Brochard
Karine
K
Decramer
Stéphane
S
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008856:Microscopy, Fluorescence; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use*; D012074:Remission Induction
D000806:Angiotensin-Converting Enzyme Inhibitors; D005938:Glucocorticoids; D011241:Prednisone