Medial temporal-lobe damage and memory for emotionally arousing odors.
Recently, we found that healthy young adults remember odors leading to large emotional reactions better than odors provoking smaller emotional reactions. Because the amygdala is believed to be critically implicated in memory for emotionally arousing information and because it is part of the primary olfactory area, we hypothesized that patients with a unilateral medial temporal-lobe resection including the amygdala would not show enhanced memory for arousing compared to nonarousing odors. We tested odor memory in 19 patients (10 left, 9 right) who had undergone a unilateral medial temporal-lobe resection including the amygdala (MTLR) for treatment of intractable epilepsy and 19 healthy control subjects. Healthy individuals and patients with left or right MTLR showed comparable subjective emotional reactions to odors. Similarly, healthy individuals and patients with MTLR remembered unpleasant odors better than pleasant ones. However, unlike healthy individuals, patients with MTLR did not show better memory for emotionally arousing odors compared to nonarousing ones. Patients undergoing a MTLR, whether in the left or right hemisphere, lose the specific memory advantage that odors causing strong emotional reactions normally have.
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal H3A 2B4, Québec, Canada. spouliot@ego.psych.mcgill.ca
Sandra
S
Pouliot
Marilyn
M
Jones-Gotman
D000328:Adult; D000704:Analysis of Variance; D001927:Brain Diseases / Q000473:pathology*; D016022:Case-Control Studies; D004644:Emotions / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009812:Odorants; D011601:Psychophysics; D012903:Smell / Q000502:physiology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*