Polycystic ovary syndrome: a common reproductive and metabolic disorder necessitating early recognition and treatment.
Patients who have polycystic ovary syndrome (PCOS) present with infertility, recurrent miscarriages, menstrual irregularities, hirsutism, and acne. Many also have metabolic and hormonal abnormalities that can significantly increase risk for coronary artery disease, type 2 diabetes mellitus, and endometrial carcinoma. PCOS patients should be screened for obstructive sleep apnea. Early recognition may reverse physical signs of the disease, while correcting the metabolic abnormalities that can pose significant health risk if untreated. Although lifestyle modification and pharmacotherapy are used to treat PCOS, there are few long-term outcome data regarding benefits of metabolic interventional strategies. Insulin sensitizers can improve ovulatory function, lower insulin resistance, lower androgen levels, and increase the likelihood of becoming pregnant. Further studies should yield other treatment options.
Futterweit
Walter
W
Division of Endocrinology, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA. walter.futterweit@mssm.edu
D000152:Acne Vulgaris; D000505:Alopecia; D003324:Coronary Artery Disease; D016889:Endometrial Neoplasms; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors; D013997:Time Factors