The role of ketoconazole in seborrheic dermatitis.
Although the prominent broad-spectrum activity of ketoconazole was reported in the early 1980s, its effect against Malassezia species was most pronounced; thus, it was developed for the treatment of various skin infections in which a link with these fungal species was proposed. Later, a number of ancillary properties were described for ketoconazole that comprised its anti-inflammatory, antiseborrheic, and antiproliferative profile. The incorporation of ketoconazole in an adapted vehicle could further promote its efficacy. Recently, a new formulation-an anhydrous gel containing ketoconazole 2%-was launched in which all of the ancillary properties were optimized.
Barrier Therapeutics NV, Geel, Belgium.
Marcel
M
Borgers
Hugo
H
Degreef
D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy* / Q000382:microbiology; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy*; D005782:Gels; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology*; D008290:Malassezia
D000935:Antifungal Agents; D005782:Gels; D007654:Ketoconazole