Serum beta-glucuronidase levels in children with leprosy.
A study was undertaken to find out the usefulness of determining the circulating levels of beta-glucuronidase, a lysosomal enzyme in leprosy affected children of less than 15 years of age. The serum enzyme levels were significantly higher in BB/BL patients compared to healthy control children as well as children with skin diseases other than leprosy. Treatment with Multidrug regimen advocated by WHO for multi/paucibacillary leprosy resulted in a significant fall in the serum enzyme levels in BB and BL cases. The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.
RML Hospital, New Delhi 110 002, India.
Devki
D
Nandan
K
K
Venkatesan
Kiran
K
Katoch
R S
RS
Dayal
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007918:Leprosy / Q000097:blood* / Q000188:drug therapy; D008297:Male
D015415:Biomarkers; D007917:Leprostatic Agents; D005966:Glucuronidase