[Female patient with organic psychosyndrome and neurological focal signs after immunosuppressant therapy].
Cerebral toxoplasmosis nearly exclusively affects immunodeficient or immunocompromised patients. Mostly, it is a reactivation of latent toxoplasmosis. The pathogens, persisting in the reticuloendothelial system of heart and skeletal muscle cells, are causing a multifocal necrotizing encephalitis. The characteristic clinical features are organic psychosyndrome and focal neurological signs such as monoparesis, hemiparesis, aphasia, or seizures. Here we describe a 56-years-old patient who developed cerebral toxoplasmosis after receiving stem-cell transplantation treatment for acute myeloic leukemia, and we discuss the clinical features, differential diagnoses and therapeutic strategies.
Neurologische Klinik der Universität Ulm, Rehabilitationskrankenhaus Ulm, Am Oberen Eselsberg 45, 89081, Ulm, Deutschland. peter.kuehnlein@uni-ulm.de
P
P
Kühnlein
M
M
Ringhoffer
H
H
Tumani
H J
HJ
Gdynia
D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008875:Middle Aged; D011602:Psychophysiologic Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome