Prenatally diagnosed urinary tract abnormalities: long-term outcome.
The long-term outcomes of prenatally detected uropathies are poorly documented. Limited data on fetal intervention show a possible reduction in early mortality from pulmonary hypoplasia, but no beneficial effect on long-term prognosis for renal function. Prenatally detected vesicoureteric reflux (VUR) is characterised by males with high-grade primary reflux, who are at long-term risk of renal impairment. Prenatal diagnosis and surgical intervention have contributed to a reduction in long-term morbidity in children with pelviureteric junction (PUJ) obstruction. By the same token, many children have almost certainly undergone unnecessary early pyeloplasty for an obstruction that would have resolved spontaneously. Multicystic dysplastic kidney (MCDK) carries a low (1%) risk of hypertension in childhood. The limited evidence on the long-term outcome of mild dilatation (pelvicaliectasis) indicates this is a largely innocent finding, which carries no increased risk of morbidity.
Department Paediatric Surgery, St James's University Hospital, University of Leeds, Leeds Teaching Hospitals NHS Trust, Leeds, UK. d.f.m.thomas@leeds.ac.uk
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D000818:Animals; D004108:Dilatation, Pathologic; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007670:Kidney Calices / Q000473:pathology; D007682:Kidney Pelvis / Q000473:pathology; D021782:Multicystic Dysplastic Kidney / Q000175:diagnosis; D011296:Prenatal Diagnosis; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014521:Urethra / Q000002:abnormalities; D014551:Urinary Tract / Q000002:abnormalities*; D014718:Vesico-Ureteral Reflux / Q000175:diagnosis