High-trauma fractures and low bone mineral density in older women and men.
BACKGROUND
It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively.


OBJECTIVE
To examine the association between bone mineral density (BMD) and high-trauma fracture and between high-trauma fracture and subsequent fracture in older women and men.


METHODS
Two prospective US cohort studies in community-dwelling adults 65 years or older from geographically diverse sites. The Study of Osteoporotic Fractures followed up 8022 women for 9.1 years (1988-2006). The Osteoporotic Fractures in Men Study followed up 5995 men for 5.1 years (2000-2007).


METHODS
Hip and spine BMD were assessed by dual-energy x-ray absorptiometry. Incident nonspine fractures were confirmed by radiographic report. Fractures were classified, without knowledge of BMD, as high trauma (due to motor vehicle crashes and falls from greater than standing height) or as low trauma (due to falls from standing height and less severe trauma).


RESULTS
Overall, 264 women and 94 men sustained an initial high-trauma fracture and 3211 women and 346 men sustained an initial low-trauma fracture. For women, each 1-SD reduction in total hip BMD was similarly associated with an increased risk of high-trauma fracture (multivariate relative hazard [RH], 1.45; 95% confidence interval [CI], 1.23-1.72) and low-trauma fracture (RH, 1.49; 95% CI, 1.42-1.57). Results were consistent in men (high-trauma fracture RH, 1.54; 95% CI, 1.20-1.96; low-trauma fracture RH, 1.69; 95% CI, 1.49-1.91). Risk of subsequent fracture was 34% (95% CI, 7%-67%) greater among women with an initial high-trauma fracture and 31% (95% CI, 20%-43%) greater among women with an initial low-trauma fracture, compared with women having no high- or low-trauma fracture, respectively. Risk of subsequent fracture was not modeled for men.


CONCLUSIONS
Similar to low-trauma nonspine fractures, high-trauma nonspine fractures are associated with low BMD and increased risk of subsequent fracture in older adults. High-trauma nonspine fractures should be included as outcomes in osteoporosis trials and observational studies.
Mackey
Dawn C
DC
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA. dmackey@sfcc-cpmc.net
Lui
Li-Yung
LY
Cawthon
Peggy M
PM
Bauer
Douglas C
DC
Nevitt
Michael C
MC
Cauley
Jane A
JA
Hillier
Teresa A
TA
Lewis
Cora E
CE
Barrett-Connor
Elizabeth
E
Cummings
Steven R
SR
D015502:Absorptiometry, Photon; D000059:Accidents; D000368:Aged; D015519:Bone Density; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D050723:Fractures, Bone / Q000145:classification / Q000453:epidemiology*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D010024:Osteoporosis; D012306:Risk