Chemical synthesis of dolichyl phosphates, their analogues and derivatives and application of these compounds in biochemical assays.
Several methods for simple and efficient chemical synthesis of dolichyl phosphates and their analogues and derivatives are briefly summarized with a special emphasis on chemical modification of phosphoryl group and preparation of dolichyl phosphates labelled at the omega-end and at the gamma-isoprene unit of the isoprene chain by fluorescent groups, 2-aminopyridine and 1-aminonaphtalene residues. Additionally, data on biochemical assays with application of the compounds mentioned above are presented.
Danilov
Leonid L
LL
N.K. Kochetkov Laboratory of Carbohydrate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Druzhinina
Tatyana N
TN
D000438:Alcohols / Q000737:chemistry; D004288:Dolichol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry
D000438:Alcohols; D004288:Dolichol Phosphates; C028306:dolichol monophosphate