Chemosensitive neuronal network organization in the ventral medulla analyzed by dynamic voltage-imaging.
Central chemosensitivity is critically important to maintain homeostasis. e have successfully applied a voltage-imaging technique to medullary slice and isolated brainstem-spinal cord preparations and analyzed chemosensitive neuronal network organization in the rat ventral medulla. Our results indicate that neurons in the superficial ventral medullary chemosensitive regions and deeply located medullary respiratory neuronal network are interconnected. We propose a neuronal network organization model for central chemoreceptors.
Okada
Yasumasa
Y
Keio University Tsukigase Rehabilitation Center, Department of Medicine. yasumasaokada@1979.jukuin.keio.ac.jp
Kuwana
Shun-ichi
S
Masumiya
Haruko
H
Kimura
Naofumi
N
Chen
Zibin
Z
Oku
Yoshitaka
Y
D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D013116:Spinal Cord / Q000502:physiology
D002245:Carbon Dioxide