The important and diverse roles of antibodies in the host response to Borrelia infections.
Antibodies are of critical importance in the host response to tick-borne Borrelia species that cause relapsing fever and Lyme disease. Recent studies on the role of various B cell subsets in the host response to Borrelia, complement-independent, bactericidal antibodies, and diagnostics led to this review that focuses on the array of functions that antibodies to Borrelia can perform.
LaRocca
T J
TJ
Center for Infectious Diseases, 5120 Centers for Molecular Medicine, Stony Brook, NY 11794-5120, USA.
Benach
J L
JL
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D001898:Borrelia / Q000276:immunology* / Q000472:pathogenicity; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007303:Insect Vectors / Q000276:immunology / Q000382:microbiology; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D012061:Relapsing Fever / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology; D013987:Ticks / Q000276:immunology / Q000382:microbiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D003165:Complement System Proteins