Familial association of laryngeal, lung, stomach and early-onset breast cancer.
This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome.
Jaworowska
Ewa
E
Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland. jaworowska@tlen.pl
Serrano-Fernández
Pablo
P
Tarnowska
Czesława
C
Lubiński
Jakub
J
Brzosko
Marek
M
Flicinski
Jacek
J
Masojc
Bartołomej
B
Matyjasik
Joanna
J
Scott
Rodney J
RJ
Narod
Steven A
SA
Lubiński
Jan
J
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D005192:Family Health; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000235:genetics; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011044:Poland; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics; D013577:Syndrome