A prospective evaluation of factors associated with chorioretinitis in patients with West Nile virus infection.
OBJECTIVE
To identify factors associated with the development and severity of chorioretinitis (CR) in patients with West Nile virus (WNV) infection.


METHODS
Prospective study of 38 patients with WNV infection.


RESULTS
Simple analysis showed that diabetes (p = 0.027) and age older than 45 years (p = 0.03) were significantly associated with CR. When controlling for age, only association between diabetes and CR remains statistically significant. Diabetic patients' eyes were more likely to have macular involvement (p < 0.0001), 20 or more chorioretinal lesions (p < 0.001), and lesion size 500 microm or more (p < 0.01).


CONCLUSIONS
Diabetes was a risk factor for the development and severity of WNV-associated CR.
Khairallah
Moncef
M
Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. moncef.khairallah@rns.tn
Yahia
Salim Ben
SB
Letaief
Mondher
M
Attia
Sonia
S
Kahloun
Rim
R
Jelliti
Bechir
B
Zaouali
Sonia
S
Messaoud
Riadh
R
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002825:Chorioretinitis / Q000175:diagnosis / Q000821:virology*; D048909:Diabetes Complications; D004797:Enzyme-Linked Immunosorbent Assay; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000821:virology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014901:West Nile Fever / Q000175:diagnosis / Q000821:virology*; D014902:West Nile virus / Q000276:immunology / Q000302:isolation & purification*
D000914:Antibodies, Viral; D007075:Immunoglobulin M