[Predictive value of ultra-sound densitometry as a method of selective screening for osteoporosis in primary care].
OBJECTIVE
To determine the cut-off point of calcaneous quantitative ultrasound densitometry (QUS) as a selection method in primary care for referral of postmenopausal women for dual energy x-ray absorptiometry (DXA).


METHODS
Diagnostic techniques trial.


METHODS
Four general practices in the Basque Country Autonomous Region, Spain.


METHODS
Randomly selected Caucasian women older than 45, chosen at random. A sample size of 146 women was used.


METHODS
Calcaneous ultrasound bone mineral density (BMD) measurement, using Achilles Express(R) and DXA.


METHODS
T-score BMD measurement on both devices. The sensitivity, specificity and positive predictive values of QUS and finally the ideal cut-off value were calculated.


RESULTS
The mean age of the sample was 58.2 (17.7) (range, 48-83 years old). The prevalence of women with osteoporosis, osteopaenia and normal DXA was 14.1%, 50.4% and 35.5%, respectively. The estimated sensitivity of QUS was 78.9% (56.7-91.5) and the specificity was 64.7% (55.6-72.8). The negative predictive value (NPV) was 94.9% (87.7-98.0) and the positive predictive value (PPV) was 26.8% (17.0-39.6). After the COR curve analysis, the ideal cut-off for QUS was determined as a T-score </= -2.0.


CONCLUSIONS
Given its high NPV, QUS can be considered a useful device for screening before DXA. Its low PPV means it has to be combined with other complementary or substitutive selective screening methods, such as predictive rules, which should be evaluated in each specific use.
Arana-Arri
Eunate
E
Servicio de Urgencias Generales, Hospital de Cruces, Barakaldo, Bizkaia, España. eunatea@telefonica.net
Gutiérrez Ibarluzea
Iñaki
I
Ecenarro Mugaguren
Amaia
A
Asua Batarrita
José
J
D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011320:Primary Health Care; D014463:Ultrasonography