NUP98-NSD1 fusion by insertion in acute myeloblastic leukemia.
A case of NUP98-NSD1 gene fusion resulting from the insertion of a subtelomeric part of chromosome 11p15.4 within the subtelomeric part of 5q35 was detected in a child with acute myeloblastic leukemia. This new case illustrates the importance of using fluorescence in situ hybridization followed by reverse transcriptase-polymerase chain reaction techniques to detect abnormalities involving subtelomeric chromosomal regions.
Petit
Arnaud
A
National Institute of Health and Medical Research (INSERM), EMI 0210, Necker Pediatric Hospital, 149 rue de Sèvres, 75015 Paris, France.
Radford
Isabelle
I
Waill
Marie-Christine
MC
Romana
Serge
S
Berger
Roland
R
D001483:Base Sequence; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D050939:Gene Fusion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
C522276:NUP98-NSD1 protein, human; D015514:Oncogene Proteins, Fusion