title: Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure.
abstract: We studied the IZUMO gene 9 coding exons sequence in four groups of patients including those with fertilization failure by conventional IVF. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.
authors: Laboratoire de Biologie de la Reproduction, Hôpital Nord, CHU de Saint-Etienne, Saint Etienne, France.
authors: Viviana
authors: V
authors: Granados-Gonzalez
authors: Isabelle
authors: I
authors: Aknin-Seifer
authors: Renaud-Lauriam
authors: RL
authors: Touraine
authors: Jacques
authors: J
authors: Chouteau
authors: Jean-Philippe
authors: JP
authors: Wolf
authors: Rachel
authors: R
authors: Levy
mesh_terms: D002478:Cells, Cultured; D005091:Exons / Q000235:genetics; D005260:Female; D005306:Fertilization / Q000235:genetics*; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009865:Oocytes; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D013094:Spermatozoa
chemical_list: C498176:IZUMO1 protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins