title: Intravascular US-guided direct intrahepatic portocaval shunt with an expanded polytetrafluoroethylene-covered stent-graft.
abstract: OBJECTIVE
  To retrospectively evaluate the midterm patency rate of the nitinol (Viatorr, W.L. Gore and Associates, Flagstaff, Ariz) stent-graft for direct intrahepatic portacaval shunt (DIPS) creation.
  
  
  METHODS
  Institutional Review Board approval for this retrospective HIPAA-compliant study was obtained with waiver of informed consent. DIPS was created in 18 men and one woman (median age, 54 years; range, 45-65 years) by using nitinol polytetrafluoroethylene (PTFE)-covered stent-grafts. The primary indications were intractable ascites (n = 14), acute variceal bleeding (n = 3), and hydrothorax (n = 2). Follow-up included Doppler ultrasonography at 1, 6, and 12 months and venography with manometry at 6-month intervals after the procedure. Shunt patency and cumulative survival were evaluated by using the Kaplan-Meier method and survival curves were plotted. Differences in mean portosystemic gradients (PSGs) were evaluated by using the Student t test. Multiple regression analysis for survival and DIPS patency were performed for the following parameters: Child-Pugh class, model of end-stage liver disease score, pre- and post-DIPS PSGs, pre-DIPS liver function tests, and pre-DIPS creatinine levels.
  
  
  RESULTS
  DIPS creation was successful in all patients. Effective portal decompression and free antegrade shunt flow was achieved in all patients. Intraperitoneal bleeding occurred in one patient during the procedure and was controlled during the same procedure by placing a second nitinol stent-graft. The primary patency rate was 100% at all times during the follow-up period (range, 2 days to 30 months; mean, 256 days; median, 160 days). Flow restrictors were deployed in two (11%) of 19 patients. The 1-year mortality rate was 37% (seven of 19).
  
  
  CONCLUSIONS
  Patency after DIPS creation with the nitinol PTFE-covered stent-graft was superior to that after TIPS with the nitinol stent-graft.
authors: Dotter Interventional Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L-342, Portland, OR 97201, USA. hanno.hoppe@web.de
authors: Hanno
authors: H
authors: Hoppe
authors: Stephen L
authors: SL
authors: Wang
authors: Bryan D
authors: BD
authors: Petersen
mesh_terms: D000368:Aged; D000497:Alloys; D005260:Female; D006801:Humans; D008099:Liver; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011167:Portacaval Shunt, Surgical / Q000379:methods*; D011474:Prosthesis Design; D012189:Retrospective Studies; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D000497:Alloys; C013616:nitinol; D011138:Polytetrafluoroethylene