title: Identification of the novel HLA-C allele Cw*0751.
abstract: We report the novel HLA-Cw allele HLA-Cw*0751. The allele was identified during routine sequence-based typing in our laboratory. The novel allele is identical to Cw*07020101 except for a single nucleotide change in codon 90.2 in position 268. HLA-Cw*0751 allele possesses an adenine at position 268 in exon 2, while HLA-Cw*07020101 has a cytosine at this position. Although this substitution does not change serologic reactivity of HLA-Cw7 molecule, it changes the amino acid at codon 90 from an aspartic acid to an alanine. Aspartic acid is polar and acidic, while alanine is non-polar and neutral.
authors: Kashi Clinical Laboratories, Beaverton, OR 97008, USA. ethompson@kashilab.com
authors: E M
authors: EM
authors: Thompson
authors: Z M
authors: ZM
authors: Kashi
authors: R K
authors: RK
authors: Martin
authors: J L
authors: JL
authors: Alcorn
authors: L
authors: L
authors: Tidey
mesh_terms: D000225:Adenine / Q000737:chemistry; D000483:Alleles; D019943:Amino Acid Substitution; D003596:Cytosine / Q000737:chemistry; D015236:HLA-C Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans
chemical_list: D015236:HLA-C Antigens; C527712:HLA-C*07:51 antigen; D003596:Cytosine; D000225:Adenine