title: Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues.
abstract: The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5'-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2' -3' ribose bond, furnished a set of new N-1 alkylated-2' -3' -secoinosine derivatives in high yields.
authors: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, I-80131 Naples, Italy. golivier@unina.it
authors: Giorgia
authors: G
authors: Oliviero
authors: Jussara
authors: J
authors: Amato
authors: Stefano
authors: S
authors: D'Errico
authors: Nicola
authors: N
authors: Borbone
authors: Gennaro
authors: G
authors: Piccialli
authors: Luciano
authors: L
authors: Mayol
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000737:chemistry; D007288:Inosine / Q000031:analogs & derivatives* / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012265:Ribonucleotides / Q000737:chemistry; D012266:Ribose / Q000737:chemistry*
chemical_list: C527208:N-1-dinitrophenyl-inosine; D009705:Nucleosides; D012265:Ribonucleotides; D000620:Aminoimidazole Carboxamide; D007288:Inosine; D012266:Ribose; C031143:AICA ribonucleotide