title: Early OCT changes of neuroretinal foveal thickness after first versus repeated PDT in AMD.
abstract: OBJECTIVE
  To compare early optical coherence tomography (OCT) changes in neuroretinal foveal thickness (NFT) after first versus repeated photodynamic treatment (PDT) in eyes with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD).
  
  
  METHODS
  This is a prospective comparative case series study. Consecutive AMD patients, treated with PDT due to subfoveal CNV, were enrolled. The eyes were divided into two groups: group A included eyes that had received the first initial treatment, and group B included eyes that had received repeated treatment. All eyes underwent serial examinations with OCT: prior to PDT, 1 h, and 3 months after the PDT. The primary outcome measure was early OCT change in NFT after PDT.
  
  
  RESULTS
  Thirty-three eyes of 33 patients were included in this study; 16 in group A and 17 in group B. Optical coherence tomography showed a significant increase in NFT 1 h after PDT, as compared to pre-treatment status, in group A eyes (P = 0.008) but not in group B eyes (P = 0.731). Subretinal fluid was increased in both groups (93.8% and 88.2%, respectively), whereas intraretinal fluid was remarkably more increased in group A eyes (88%) than in group B eyes (59%).
  
  
  CONCLUSIONS
  Early change in NFT, demonstrated on OCT, indicates that PDT causes different retinal response in primary versus repeated treatment of PDT for CNV due to AMD.
authors: Department of Ophthalmology, Kaplan Medical Center, Rehovot 76100, Israel. doctor.landa@gmail.com
authors: Gennady
authors: G
authors: Landa
authors: Amir
authors: A
authors: Bukelman
authors: Haya
authors: H
authors: Katz
authors: Ayala
authors: A
authors: Pollack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011446:Prospective Studies; D019233:Retreatment; D041623:Tomography, Optical Coherence; D014792:Visual Acuity