title: Metabolic control of proteasome function.
abstract: Proteasomes are major cellular proteases that are important for protein turnover and cell survival. Dysregulation of proteasome is related to many major human diseases. Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation.
authors: Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, USA.
authors: Fengxue
authors: F
authors: Zhang
authors: Andrew J
authors: AJ
authors: Paterson
authors: Ping
authors: P
authors: Huang
authors: Kai
authors: K
authors: Wang
authors: Jeffrey E
authors: JE
authors: Kudlow
mesh_terms: D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D010766:Phosphorylation; D011480:Protease Inhibitors / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000187:drug effects; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001786:Blood Glucose; D018696:Neuroprotective Agents; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D025801:Ubiquitin; D017868:Cyclic AMP-Dependent Protein Kinases; D046988:Proteasome Endopeptidase Complex