title: Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
abstract: Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.
authors: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Kagawa, Japan. maruyama@kph.bunri-u.ac.jp
authors: Tokumi
authors: T
authors: Maruyama
authors: Yosuke
authors: Y
authors: Demizu
authors: Shigetada
authors: S
authors: Kozai
authors: Myriam
authors: M
authors: Witvrouw
authors: Christophe
authors: C
authors: Pannecouque
authors: Jan
authors: J
authors: Balzarini
authors: Robert
authors: R
authors: Snoecks
authors: Graciella
authors: G
authors: Andrei
authors: Erik
authors: E
authors: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C527151:2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate; C527152:2'-O-carbomoylmethyladenosine 3'-(thymidine 5'-phosphate); C527156:3-(3,5-dimethylbenzyl)uracil; D000998:Antiviral Agents; D012263:Ribonucleosides; D014498:Uracil; D000241:Adenosine