TPO-independent megakaryocytopoiesis.
Megakaryocytopoiesis is a continuous developmental process of platelet production. In this process, a complex network of hemopoietic growth factors are involved, among which TPO (thrombopoietin) is the most thoroughly investigated regulator of MKs (megakaryocytes). In addition to TPO, other regulators also have non-negligible effects on megakaryocytopoiesis. The majority of their effects are independent of TPO signaling. To date, TPO-independent megakaryocytopoiesis forms a regulatory system that includes four signals and (an) unknown signaling pathway(s). These four pathways are the gp 130 (glycoprotein 130)-dependent signaling pathway, the Notch pathway, NMDA (N-methyl-d-aspartate) receptor-mediated signaling, and the SDF-1 (stromal cell-derived factor-1)/FGF-4 (fibroblast growth factor-4) paradigm. Understanding of the TPO-independent regulatory system is important because the system may offer additional opportunities to understand the developmental process and the mechanisms of disorders characterized by abnormal MK and platelet production, such as thrombocytopenia and thrombocythemia, and to advance the development of therapeutics.
Zheng
Cuiling
C
State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, PR China.
Yang
Renchi
R
Han
Zhongchao
Z
Zhou
Bin
B
Liang
Lu
L
Lu
Min
M
D000818:Animals; D054377:Chemokine CXCL12 / Q000502:physiology; D050822:Cytokine Receptor gp130 / Q000502:physiology; D051519:Fibroblast Growth Factor 4 / Q000502:physiology; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction; D034061:Thrombopoiesis; D013926:Thrombopoietin / Q000502:physiology*
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; C496445:FGF4 protein, human; D051519:Fibroblast Growth Factor 4; D016194:Receptors, N-Methyl-D-Aspartate; D051880:Receptors, Notch; D050822:Cytokine Receptor gp130; D013926:Thrombopoietin