New mutations of Nogo-C in hepatocellular carcinoma.
The neurite outgrowth inhibitor Nogo has attracted great interest, but its relevance with hepatocellular carcinoma has not been reported. This paper first found mutations of Nogo-C in HCC patients from Qidong in China: A172G (Thr58Ala), A340G (Arg114Gly), A571G (Ile191Val). In six examined patient cases from Qidong, the mutations occurred in five cases. The mutation Arg114Gly was predicted bioinformatically to affect Nogo-66 dimensional structure of Nogo-C. Our previous works also had indicated that mutant Nogo-C promoted liver cancer cell line apoptosis and resulted in molecular marker of HCC p53 gene transfer from nucleus to cytoplast. Above results revealed a new physiological role and clinical implications of Nogo-C on HCC.
Chen
Yicun
Y
The Jiangsu Key Laboratory of Molecular and Medical Biotechnology, The College of Life Science, Nanjing Normal University, Nanjing 210097, P.R. China.
Tang
Xiaojun
X
Zhang
Xiran
X
Zhuang
Linyuan
L
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009185:Myelin Proteins / Q000235:genetics*; D000070798:Nogo Proteins; D011487:Protein Conformation
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human