title: Assessment of the predictive value of serum progesterone levels on early pregnancy prognosis in spontaneous twin gestations: a prospective study.
abstract: OBJECTIVE
  The aim of this study was to assess the predictive value of serum progesterone levels in early pregnancy prognosis in spontaneous dichorionic-diamniotic twin gestations.
  
  
  METHODS
  This study was carried out among 38 spontaneous dichorionic-diamniotic twin gestations between January 2003 and June 2005 in the Department of Obstetrics and Gynaecology at the Gulhane Military Medical Academy. Serum progesterone levels were measured at 7 and 10 weeks' gestation and pregnancies were followed until 14 gestational weeks by ultrasound examination.
  
  
  RESULTS
  We found that a progesterone level of 58 nmol/l in the 7th gestational week and of 51 ng/ml at 10 gestational weeks has a predictive value for viable intrauterine twin pregnancies with 83% sensitivity and 69% specificity and 83% sensitivity and 84% specificity, respectively.
  
  
  CONCLUSIONS
  Progesterone levels in the early gestational weeks may be a biochemical marker for the prediction of a twin pregnancy outcome and may reduce the number of ultrasound examinations.
authors: Department of Obstetrics and Gynaecology, Gulhane Military Medical Academy and Medical School, Ankara, Turkey. ugoktolga@yahoo.com <ugoktolga@yahoo.com>
authors: Umit
authors: U
authors: Goktolga
authors: Sadettin
authors: S
authors: Gungor
authors: Seyit Temel
authors: ST
authors: Ceyhan
authors: Ugur
authors: U
authors: Keskin
authors: Ulas
authors: U
authors: Fidan
authors: Kazim
authors: K
authors: Gezginc
authors: Iskender
authors: I
authors: Baser
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood*; D011272:Pregnancy, Multiple / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D011374:Progesterone