title: Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats.
abstract: Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
authors: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
authors: Victor Raj Mohan
authors: VR
authors: Chandrasekaran
authors: Chang-Hsin
authors: CH
authors: Wan
authors: Li-Lian
authors: LL
authors: Liu
authors: Dur-Zong
authors: DZ
authors: Hsu
authors: Ming-Yie
authors: MY
authors: Liu
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000208:Acute Disease; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005978:Glutathione / Q000378:metabolism; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000008:administration & dosage* / Q000627:therapeutic use; D031685:Sesamum; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D018712:Analgesics, Non-Narcotic; D013481:Superoxides; D017665:Hydroxyl Radical; D000082:Acetaminophen; D012715:Sesame Oil; D005978:Glutathione