Development of the novel drug releasing system triggered by hybridization with target sequence.
We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.
Nagatsugi
F
F
Institute of Multidisciplinary Research for Advanced Materials Tohoku University, Sendai, Japan. nagatugi@tagen.tohoku.ac.jp
Nakayama
Shizuka
S
Sasaki
Shigeki
S
D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D009693:Nucleic Acid Hybridization / Q000187:drug effects; D009841:Oligonucleotides / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013440:Sulfides / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D009841:Oligonucleotides; D011687:Purines; D013440:Sulfides; D014753:Vinyl Compounds; D004247:DNA