Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.
Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Zhao
Long Xuan
LX
Choi
Won Jun
WJ
Pal
Shantanu
S
Park
Yeon Hee
YH
Lee
Sang Kook
SK
Chun
Moon Woo
MW
Lee
Young B
YB
Ahn
Chang Ho
CH
Moon
Hyung Ryong
HR
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011743:Pyrimidines