The role of transforming growth factor-beta and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury.
Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-beta and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-beta and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-beta to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
Kim
Hak-Jun
HJ
Department of Orthopedic Surgery, Seoul Veterans Hospital, Seoul, Korea.
Kang
Sun-Woong
SW
Lim
Hong-Chul
HC
Han
Seung-Bum
SB
Lee
Jae-Sun
JS
Prasad
Leela
L
Kim
Yoon-Jung
YJ
Kim
Byung-Soo
BS
Park
Jung-Ho
JH
D000125:Achilles Tendon / Q000293:injuries; D000818:Animals; D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000502:physiology* / Q000627:therapeutic use*; D002111:Calcaneus / Q000293:injuries*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D013708:Tendon Injuries / Q000628:therapy*; D016212:Transforming Growth Factor beta / Q000502:physiology* / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive; D016212:Transforming Growth Factor beta