title: Electrically evoked auditory steady-state responses in a guinea pig model: latency estimates and effects of stimulus parameters.
abstract: Cochlear implant speech processors typically extract envelope information of speech signals for presentation to the auditory nerve as modulated trains of electric pulses. Recent studies showed the feasibility of recording, at the scalp, the electrically evoked auditory steady-state response using amplitude-modulated electric stimuli. Sinusoidally amplitude-modulated electric stimuli were used to elicit such responses from guinea pigs in order to characterize this response. Response latencies were derived to provide insight regarding neural generator sites. Two distinct sites, one cortical and another more peripheral, were indicated by latency estimates of 22 and 2 ms, respectively, with the former evoked by lower (13-49 Hz) and the latter by higher (55-320 Hz) modulation frequencies. Furthermore, response amplitudes declined with increasing carrier frequency, exhibited a compressive growth with increasing modulation depths, and were sensitive to modulation depths to as low as 5%.
authors: Department of Speech Pathology and Audiology, University of Iowa, Iowa City, Iowa, USA. jeng@ohio.edu
authors: Fuh-Cherng
authors: FC
authors: Jeng
authors: Paul J
authors: PJ
authors: Abbas
authors: Carolyn J
authors: CJ
authors: Brown
authors: Charles A
authors: CA
authors: Miller
authors: Kirill V
authors: KV
authors: Nourski
authors: Barbara K
authors: BK
authors: Robinson
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003638:Deafness / Q000139:chemically induced / Q000517:prevention & control*; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006168:Guinea Pigs; D023421:Models, Animal; D009355:Neomycin; D010033:Otitis Media / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology*; D012984:Software; D013016:Sound
chemical_list: D009355:Neomycin