Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group.
Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin-dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the -786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the 'ab' genotype of the 27-bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.
Djidjik
R
R
Laboratoire de Biologie, Unité d'Immunologie, CHU Beni-Messous, Algiers, Algeria.
Ghaffor
M
M
Brun
M
M
Gharnaout
M
M
Salah
S S
SS
Boukouaci
W
W
Djidjik
H
H
Benyounes
A
A
Koumaravelou
K
K
Krishnamoorthy
R
R
Abbadi
M C
MC
Charron
D
D
Tamouza
R
R
D000293:Adolescent; D000328:Adult; D000462:Algeria; D000818:Animals; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052248:Nitric Oxide Synthase Type I / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D012130:Respiratory Hypersensitivity / Q000235:genetics*
C496314:NOS3 protein, human; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III