title: In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
abstract: Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
authors: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. diana.nersesian@abbott.com
authors: Diana L
authors: DL
authors: Nersesian
authors: Lawrence A
authors: LA
authors: Black
authors: Thomas R
authors: TR
authors: Miller
authors: Timothy A
authors: TA
authors: Vortherms
authors: Timothy A
authors: TA
authors: Esbenshade
authors: Arthur A
authors: AA
authors: Hancock
authors: Marlon D
authors: MD
authors: Cowart
mesh_terms: D000818:Animals; D054828:Histamine H3 Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C520125:2-methylpyrrolidine; D054828:Histamine H3 Antagonists; D011759:Pyrrolidines