title: Biopsy proven acute tubular necrosis associated with vancomycin in a child: case report and literature review.
abstract: Vancomycin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. The drug does appear, however, to increase the nephrotoxicity of concurrently administered aminoglycosides. The extent of direct tubular toxicity attributable to vancomycin, especially in the absence of aminoglycoside treatment, does not appear to have been previously described. We report a case of biopsy-proven acute tubular necrosis secondary to vancomycin toxicity in a 13-year-old boy where there was no likely alternate explanation for toxic or ischemic injury. No hemodialysis was required, and the patient made a full recovery with subsequently regained renal function.
authors: Department of Pediatrics, E-DA Hospital/I-Shou University, Yan-Chau Shiang, Kaohsiung County, Taiwan.
authors: Chan-Yao
authors: CY
authors: Wu
authors: Jyh-Seng
authors: JS
authors: Wang
authors: Yee-Hsuan
authors: YH
authors: Chiou
authors: Chen-Yin
authors: CY
authors: Chen
authors: Yu-Tsun
authors: YT
authors: Su
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008181:Lupus Nephritis / Q000150:complications / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin