17beta-estradiol enhances contact hypersensitivity in a hair cycle-dependent manner and retards thymic atrophy with age.
The effect of 17beta-estradiol (E2) on murine contact hypersensitivity (CHS), thymic atrophy, and hair-cycle change related to growth was investigated. Female mice were ovariectomized. E2 (3.2 microg) was injected subcutaneously along with the sensitizer 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (OXA), and a hypersensitive reaction was elicited with OXA on the ear in mice of various ages. E2 enhanced allergy only in 3- and 7-week-old mice, just prior to hair regrowth. Age-related thymus atrophy was repressed in the E2-treated mice compared with the control mice. E2 alone did not cause thymus involution, but it did inhibit thymus involution and regeneration after CHS.
Sakazaki
Fumitoshi
F
Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Ueno
Hitoshi
H
Nakamuro
Katsuhiko
K
D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001284:Atrophy; D003877:Dermatitis, Contact / Q000473:pathology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D006197:Hair / Q000254:growth & development* / Q000502:physiology; D016131:Lymphocyte Subsets / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D012038:Regeneration / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology*
D004958:Estradiol