Stroke prevention during surgery for deep-seated gliomas.
OBJECTIVE
New motor deficit after surgery for deep-seated gliomas can occur from subcortical ischemia of the pyramidal tract. Motor evoked potentials (MEPs) validly indicate impending motor tract ischemia in cerebrovascular surgery. This study determines the feasibility and clinical utility of MEP monitoring for ischemic complication avoidance during surgery for deep-seated, specifically insular gliomas.


METHODS
MEPs were recorded during 100 operations of insular gliomas. Intraoperative MEP results were correlated with postoperative clinical and imaging results.


RESULTS
Useful MEP monitoring was possible in 89/100 cases, 88 of which were assessable since one patient died early postoperatively. Stable recordings warranted unimpaired motor outcome in 47/88 cases (53%). Surgical intervention reversed MEP attenuation in 26 of the remaining 41 cases (30% of the overall series) to prevent motor deficit except transient paresis in 12 (14%). Irreversible MEP changes without loss in eight cases (9%) resulted in only transient new deficit in seven cases, except one with permanent new paresis. Permanent paresis also occurred in seven cases (8%) where complete MEP loss could not be prevented. Permanent paresis arose exclusively through stroke of the deep motor pathways, whereas transient deficit typically corresponded to transitory ischemia of the pyramidal tract. MEP changes attributable to ischemic events frequently occurred spatially and temporally uncorrelated to resection in critical proximity of the motor tract.


CONCLUSIONS
Ischemia in deep-seated glioma surgery usually occurs uncorrelated to resection close to the pyramidal tract. MEP monitoring efficiently helps detect ischemia early and to avert definite stroke and permanent new paresis in part of these cases.
Neuloh
G
G
Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany. neuloh@ukb.uni-bonn.de
Simon
M
M
Schramm
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D005910:Glioma / Q000601:surgery*; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome