title: Desymmetrization of 7-azabicycloalkenes by tandem olefin metathesis for the preparation of natural product scaffolds.
abstract: BACKGROUND
  Tandem olefin metathesis sequences are known to be versatile for the generation of natural product scaffolds and have also been used for ring opening of strained carbo- and heterocycles. In this paper we demonstrate the potential of these reactions for the desymmetrization of 7-azabicycloalkenes.
  
  
  RESULTS
  We have established efficient protocols for the desymmetrization of different 7-azabicycloalkenes by intra- and intermolecular tandem metathesis sequences with ruthenium based catalysts.
  
  
  CONCLUSIONS
  Desymmetrization of 7-azabicycloalkenes by olefin metathesis is an efficient process for the preparation of common natural product scaffolds such as pyrrolidines, indolizidines and isoindoles.
authors: Institut für Organische Chemie, Heinrich-Buff-Ring 58, Justus-Liebig-Universität Giessen, 95392 Giessen, Germany. wolfgang.maison@org.chemie.uni-giessen.de
authors: Wolfgang
authors: W
authors: Maison
authors: Marina
authors: M
authors: Büchert
authors: Nina
authors: N
authors: Deppermann