title: Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa.
abstract: Hepatitis B virus (HBV) surface antigen (HBsAg) was found in 9.2% of 1,186 pregnant women from Gabon, of whom 10.1% had the HBe antigen and 89.9% had anti-HBe antibodies. Antibodies to the hepatitis delta virus (HDV) were found in 15.6% of the HBsAg-positive women. The HBV strains were of the A3 and E genotypes. The HDV strains belonged to HDV clades 1 and 8. These results provide clear evidence that HDV clade 8 is indigenous to Africa.
authors: Laboratoire de Virologie, Centre International de Recherches Médicales, BP 769, Franceville, Gabon.
authors: Maria
authors: M
authors: Makuwa
authors: Mélanie
authors: M
authors: Caron
authors: Sandrine
authors: S
authors: Souquière
authors: Gabriel
authors: G
authors: Malonga-Mouelet
authors: Antoine
authors: A
authors: Mahé
authors: Mirdad
authors: M
authors: Kazanji
mesh_terms: D000293:Adolescent; D000328:Adult; D016000:Cluster Analysis; D019353:Endemic Diseases; D005681:Gabon / Q000453:epidemiology; D014644:Genetic Variation; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000453:epidemiology* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification; D003699:Hepatitis D / Q000453:epidemiology* / Q000821:virology; D003698:Hepatitis Delta Virus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D037841:Pregnant People; D017422:Sequence Analysis, DNA; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens