Studies on the later stage of the biosynthesis of pleuromutilin.
Mutilin (4) and deoxy analogues 2 and 3 are biosynthetic precursors of pleuromutilin (1) in the later stage of biosynthesis. Precursors 2 and 3 are required for studies on the oxygenation steps in biosynthesis, and were synthesized from readily available 1 via 4 by deoxygenation of the hydroxy groups. Feeding experiments with the (2)H-labeled precursors confirmed their microbial conversion into 1.
Tsukagoshi
Tae
T
Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan.
Tokiwano
Tetsuo
T
Oikawa
Hideaki
H
D000363:Agaricales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D003903:Deuterium; D004224:Diterpenes / Q000378:metabolism; D007659:Ketones / Q000378:metabolism*; D011083:Polycyclic Compounds / Q000378:metabolism*; D000097567:Pleuromutilins
D000900:Anti-Bacterial Agents; D003903:Deuterium; D004224:Diterpenes; D007659:Ketones; D011083:Polycyclic Compounds; D000097567:Pleuromutilins; C475718:mutilin