Antibodies against fetal brain in sera of mothers with autistic children.
Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism.
Singer
Harvey S
HS
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States. hsinger@jhmi.edu
Morris
Christina M
CM
Gause
Colin D
CD
Gillin
Pam K
PK
Crawford
Stephen
S
Zimmerman
Andrew W
AW
D000328:Adult; D000368:Aged; D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood / Q000276:immunology; D001321:Autistic Disorder / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001722:Birth Order; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000276:immunology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D009035:Mothers; D004676:Myelin Basic Protein / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009474:Neurons / Q000276:immunology; D010298:Parity; D011247:Pregnancy; D051381:Rats; D013045:Species Specificity
D000910:Antibodies, Heterophile; D001323:Autoantibodies; D019208:Brain-Derived Neurotrophic Factor; D005904:Glial Fibrillary Acidic Protein; D007074:Immunoglobulin G; D007518:Isoantibodies; D007519:Isoantigens; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins