Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder.
We have shown that plasma apolipoprotein E is significantly decreased in treatment-free subjects with schizophrenia spectrum and bipolar disorder but increases after treatment in bipolar disorder. Levels of apolipoprotein D were not changed by treatment. Hence changed apolipoprotein E could be involved in abnormalities in lipid homeostasis in some subjects with psychiatric diseases.
Dean
Brian
B
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia. bdean_mhri@iprimus.com.au
Digney
Alison
A
Sundram
Suresh
S
Thomas
Elizabeth
E
Scarr
Elizabeth
E
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood*; D015153:Blotting, Western; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use; D008297:Male; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D001057:Apolipoproteins E; D016651:Lithium Carbonate; D002746:Chlorpromazine