Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
OBJECTIVE
To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics.


METHODS
A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC).


RESULTS
We identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively.


CONCLUSIONS
The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.
Liao
Yi-Chu
YC
Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin
Hsiu-Fen
HF
Rundek
Tanja
T
Cheng
Rong
R
Hsi
Edward
E
Sacco
Ralph L
RL
Juo
Suh-Hang Hank
SH
D000368:Aged; D017691:Caribbean Region / Q000208:ethnology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides