Global analysis of mRNA splicing.
Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.
Moore
Michael J
MJ
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Silver
Pamela A
PA
D017398:Alternative Splicing; D000818:Animals; D019295:Computational Biology; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger