Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology.
The traditional Chinese medicine, Salvia miltiorrhiza (Danshen), promotes blood circulation and relieves blood stasis, also demonstrating good antioxidant activity. In the present study, therefore, the antioxidant activities of medicinal plant materials prepared using nanotechnology or traditional grinding methods were compared using three biological assays. It was found that the nanotechnology preparation had stronger antioxidant bioactivities. Complementary quantitative analysis of four active constituents, salvianolic acid B, cryptotanshinone, tanshinone I and tanshinone IIA, by HPLC revealed only marked differences for salvianolic acid B. The results indicate that the polar active constituent in the nanotechnology samples was released faster compared to the traditionally powdered samples.
Liu
Je-Ruei
JR
Department of Animal Science and Technology and Institute of Biotechnology, National Taiwan University, Taipei 102, Taiwan, ROC.
Chen
Guo-Feng
GF
Shih
Hui-Nung
HN
Kuo
Ping-Chung
PC
D000975:Antioxidants / Q000032:analysis* / Q000302:isolation & purification*; D001572:Benzofurans / Q000032:analysis / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification*; D016166:Free Radical Scavengers / Q000032:analysis / Q000302:isolation & purification; D007502:Iron Chelating Agents / Q000032:analysis / Q000302:isolation & purification; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010618:Phenanthrolines / Q000737:chemistry* / Q000302:isolation & purification*; D019163:Reducing Agents / Q000032:analysis / Q000302:isolation & purification; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D053630:Depsides
D000975:Antioxidants; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D010618:Phenanthrolines; D019163:Reducing Agents; C028972:dan-shen root extract; C076944:salvianolic acid B; D053630:Depsides