Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
OBJECTIVE
Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP-420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM.


METHODS
We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60.2 +/- 11.3 years, body mass index (BMI) 24.1 +/- 3.9) whose overnight fasting sera were available. Serum resistin was measured using ELISA.


RESULTS
Serum resistin was higher in subjects with either obesity (P = 0.041), low HDL (P = 0.004), high triglycerides (TG) (P = 0.019), hypertension (HT) (P = 0.001) or atherosclerosis (P = 0.012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high-sensitivity C-reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0.008), TG (P = 0.041), HT (P = 0.031) and hsCRP (P = 0.004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0.001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings.


CONCLUSIONS
Serum resistin was positively correlated with the accumulation of MetS factors in T2DM.
Osawa
Haruhiko
H
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan. harosawa@m.ehime-u.ac.jp
Ochi
Masaaki
M
Tabara
Yasuharu
Y
Kato
Kenichi
K
Yamauchi
Junko
J
Takata
Yasunori
Y
Nishida
Wataru
W
Onuma
Hiroshi
H
Shimizu
Ikki
I
Fujii
Yasuhisa
Y
Miki
Tetsuro
T
Ohashi
Jun
J
Makino
Hideichi
H
D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004198:Disease Susceptibility / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
D008055:Lipids; C499624:RETN protein, human; D052243:Resistin