title: Highly effective non-explosive activators based on saccharin for the synthesis of oligonucleotides and phosphoramidites.
abstract: A new class of non-explosive activators has been developed based on heterocyclic tertiary amine salts of saccharin. These salts have been found to be highly effective in the synthesis of oligonucleotides and nucleoside phosphoramidites.
authors: Avecia Biotechnology Inc., 125 Fortune Boulevard, Milford, MA 01757, USA. Nanda.Sinha@Avecia.com
authors: Nanda D
authors: ND
authors: Sinha
authors: Patrick
authors: P
authors: Foster
authors: Satya N
authors: SN
authors: Kuchimanchi
authors: Greg
authors: G
authors: Miranda
authors: Saied
authors: S
authors: Shaikh
authors: Dennis
authors: D
authors: Michaud
mesh_terms: D053834:Explosive Agents / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D012439:Saccharin / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D053834:Explosive Agents; D006571:Heterocyclic Compounds; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012439:Saccharin