Drug discovery and development with plant-derived compounds.
An overview is given on current efforts in drug development based on plant-derived natural products. Emphasis is on projects which have advanced to clinical development. Therapeutic areas covered include cancer, viral infections including HIV, malaria, inflammatory diseases, nociception and vaccine adjuvants, metabolic disorders, and neurodegenerative diseases. Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity.
Potterat
Olivier
O
University of Basel, Institute of Pharmaceutical Biology, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Hamburger
Matthias
M
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000627:therapeutic use; D000544:Alzheimer Disease / Q000188:drug therapy; D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use; D000962:Antimalarials / Q000302:isolation & purification / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use; D000998:Antiviral Agents / Q000302:isolation & purification / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000302:isolation & purification / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000627:therapeutic use; D004364:Pharmaceutical Preparations; D028321:Plant Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D002317:Cardiovascular Agents; D007004:Hypoglycemic Agents; D018696:Neuroprotective Agents; D004364:Pharmaceutical Preparations; D028321:Plant Preparations