Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes.
OBJECTIVE
Transcription factor Neurogenin 3 (NGN3) is considered as a candidate gene for the development of type 2 diabetes. The aim of the current study was to investigate the relevance of NGN3 variants for the clinical spectrum of diabetes development and disease progressions.


METHODS
A total of 552 subjects with increased risk of type 2 diabetes were investigated. They underwent a 75 g OGTT with measurements of plasma glucose, insulin and proinsulin at fasting and at 30, 60, 90 and 120 minutes after the glucose challenge, repeated after 3 years. The NGN3 SNPs, Gly167Arg and Ser199Phe were genotyped.


RESULTS
Patients with type 2 diabetes carrying the variant genotype at SNP199 presented with significantly higher proinsulin levels. Proinsulin level was also associated with progression of diabetes mellitus. There was a discrete association of the Ser199Phe variant with evolution of the disease status.


CONCLUSIONS
A genetic variation in NGN3 gene may be among the genetic determinants involved in the pathogenesis of diabetes.
Li
J
J
Department of Endocrinopathies and Metabolic Diseases, Medical Faculty Carl-Gustav-Carus of the Technical University Dresden, Dresden, Germany.
Bergmann
A
A
Reimann
M
M
Schulze
J
J
Bornstein
S R
SR
Schwarz
P E H
PE
D000368:Aged; D019943:Amino Acid Substitution; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D018450:Disease Progression; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D006946:Hyperinsulinism / Q000235:genetics*; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011384:Proinsulin / Q000097:blood*; D049629:Waist-Hip Ratio
D051792:Basic Helix-Loop-Helix Proteins; D007328:Insulin; D009419:Nerve Tissue Proteins; D011384:Proinsulin; C498695:NEUROG3 protein, human