title: Neuromuscular block and the electroencephalogram during sevoflurane anaesthesia.
abstract: The effect of neuromuscular block on the anaesthetic depth of hypnosis is an elusive question. We simultaneously investigated the influence of neuromuscular block on the bispectral index, a measure of hypnosis during general anaesthesia, and on the electroencephalogram. Patients were anaesthetized with sevoflurane. Noxious tetanic electrical stimulation was applied on two occasions: before and after profound neuromuscular block achieved with rocuronium. Neuromuscular block significantly attenuated the effect from noxious stimulation on electroencephalogram power and synchrony in the gamma band (P<0.05), and the corresponding effect on bispectral index (P<0.02). These findings are probably due to the reduced arousing afferent input from paralysed muscles, and not to changes in the frontal electromyogram.
authors: Department of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden. andrease@ltkalmar.se
authors: Andreas
authors: A
authors: Ekman
authors: Roland
authors: R
authors: Flink
authors: Eva
authors: E
authors: Sundman
authors: Lars I
authors: LI
authors: Eriksson
authors: Lars
authors: L
authors: Brudin
authors: Rolf
authors: R
authors: Sandin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D003627:Data Interpretation, Statistical; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009213:Myography; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010812:Physical Stimulation; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D009466:Neuromuscular Blocking Agents; D000077149:Sevoflurane