title: Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer.
abstract: The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population.
authors: Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.
authors: Tess V
authors: TV
authors: Clendenen
authors: Alan A
authors: AA
authors: Arslan
authors: Karen L
authors: KL
authors: Koenig
authors: Kerstin
authors: K
authors: Enquist
authors: Isaac
authors: I
authors: Wirgin
authors: Asa
authors: A
authors: Agren
authors: Annekatrin
authors: A
authors: Lukanova
authors: Hubert
authors: H
authors: Sjodin
authors: Anne
authors: A
authors: Zeleniuch-Jacquotte
authors: Roy E
authors: RE
authors: Shore
authors: Göran
authors: G
authors: Hallmans
authors: Paolo
authors: P
authors: Toniolo
authors: Eva
authors: E
authors: Lundin
mesh_terms: D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018167:Receptors, Calcitriol / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol