[Platelet autoantibody and its impact on platelet in patients with idiopathic thrombocytopenic purpura].
OBJECTIVE
To detect the platelet autoantibody in the patients with idiopathic thrombocytopenic purpura (ITP) and to investigate the impact of the autoantibody on the count and function of platelet.


METHODS
The glycoprotein specific autoantibody was measured by MAIPA in the ITP patients, non-ITP patients and healthy people. The serum of the ITP patients were added to the healthy plasma with rich platelet and the platelet aggregation function was measured.


RESULTS
The platelet autoantibody was found in 65.4% of the ITP patients. The platelet counts in the ITP patients with positive autoantibody were significantly lower than those without the autoantibody. The platelet counts were negatively correlated with the levels of the autoantibody, with a correlation coefficient of -0.724 for the anti GP IIb/ IIIa autoantibody and -0.571 for the anti GP Ib/ IX autoantibody. The aggregation of normal platelets was inhibited in ten out of the 26 patients, among whom nine had platelet autoantibody.


CONCLUSIONS
The platelet autoantibody affects not only the count but also the function of platelet.
Zhou
Jing
J
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Liao
Juan
J
Jiang
Neng-gang
NG
Kuang
Ling-han
LH
D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood*
D001323:Autoantibodies