Syntheses of (S,S)-reboxetine via a catalytic stereospecific rearrangement of beta-amino alcohols.
The formal total synthesis of (S,S)-reboxetine has been realized by two different approaches using a stereospecific rearrangement of beta-amino alcohols catalyzed by (CF3CO)2O.
Métro
Thomas-Xavier
TX
Laboratoire de Chimie Organique, ESPCI, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Pardo
Domingo Gomez
DG
Cossy
Janine
J
D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry; D000077593:Reboxetine; D013237:Stereoisomerism
D000605:Amino Alcohols; D009025:Morpholines; D000077593:Reboxetine