title: N-acetylcysteine for prevention of acute renal failure in patients with chronic renal insufficiency undergoing cardiac surgery: a prospective, randomized, clinical trial.
abstract: OBJECTIVE
  To assess the preventive effect of the antioxidant N-acetylcysteine on postoperative acute renal failure in patients with renal insufficiency undergoing cardiac surgery.
  
  
  METHODS
  Randomized, placebo-controlled, prospective study.
  
  
  METHODS
  University cardiology center.
  
  
  METHODS
  Two hundred fifty-four consecutive patients with chronic renal insufficiency (estimated creatinine clearance < or = 60 mL/min) undergoing elective cardiac surgery.
  
  
  METHODS
  Patients were randomized to receive N-acetylcysteine (n = 129) or placebo (n = 125). Patients of the N-acetylcysteine group received four boluses of intravenous N-acetylcysteine (1200 mg every 12 hrs, starting immediately before cardiac surgery).
  
  
  RESULTS
  The incidence of postoperative acute renal failure (> 25% increase in serum creatinine from baseline) and the in-hospital clinical course were evaluated. Acute renal failure occurred in 46% of patients and was associated with increased in-hospital mortality (7% vs. 0.7%; p = .024). It occurred in 52% of control patients and 40% of N-acetylcysteine-treated patients (p = .06). In-hospital mortality and need for renal replacement therapy were not affected by N-acetylcysteine, but a lower percentage of N-acetylcysteine-treated patients required mechanical ventilation prolonged for > 48 hrs (3% vs. 18%; p < .001) and had an intensive care unit stay > 4 days (13% vs. 33%; p < .001).
  
  
  CONCLUSIONS
  Intravenous administration of N-acetylcysteine does not clearly prevent postoperative acute renal failure in patients with renal insufficiency undergoing cardiac surgery.
authors: Anesthesia and Critical Care Unit, Centro Cardiologico Monzino, I.R.C.C.S, Institute of Cardiology, University of Milan, Milan, Italy.
authors: Erminio
authors: E
authors: Sisillo
authors: Roberto
authors: R
authors: Ceriani
authors: Franco
authors: F
authors: Bortone
authors: Glauco
authors: G
authors: Juliano
authors: Luca
authors: L
authors: Salvi
authors: Fabrizio
authors: F
authors: Veglia
authors: Cesare
authors: C
authors: Fiorentini
authors: Giancarlo
authors: G
authors: Marenzi
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006331:Heart Diseases / Q000150:complications* / Q000601:surgery*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D017582:Renal Replacement Therapy; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D003404:Creatinine; D000111:Acetylcysteine