E proteins enforce security checkpoints in the thymus.
In this issue of Immunity, two studies define new roles for E proteins in thymocyte development. Agata et al. (2007) show a new role in beta selection; Jones and Zhuang (2007) demonstrate a role in positive selection.
Kersh
Gilbert J
GJ
Department of Pathology and Laboratory Medicine, Emory University, 7311 Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA 30322, USA. gkersh@emory.edu
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D015329:Gene Rearrangement, T-Lymphocyte; D019674:Genes, T-Cell Receptor beta; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D051820:TCF Transcription Factors / Q000502:physiology*; D058125:Transcription Factor 7-Like 1 Protein
D051792:Basic Helix-Loop-Helix Proteins; D011948:Receptors, Antigen, T-Cell; D051820:TCF Transcription Factors; D058125:Transcription Factor 7-Like 1 Protein; C489532:Tcf12 protein, mouse; C075668:Tcf3 protein, mouse; C544913:Tcf7l1 protein, mouse