[Topical steroid injection for refractory oral chronic graft-versus-host disease].
The standard treatment for refractory oral chronic graft versus host disease (GVHD) has not been established. We present a case of AML accompanied by oral chronic GVHD in a 55-year-old man after allogeneic stem cell transplantation. The stomatitis of the patient was prolonged for a year and resistant to standard immunosuppressant therapy, including systemic administration of prednisolone and tacrolimus; however, local injection of 0.2% dexamethasone (0.5 mg per cm2) into the ulcerative area was drastically effective in improving refractory mucositis and mitigated a vicious cycle of mucosal damage and poor oral hygiene.
Ohbayashi
Yumiko
Y
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Imataki
Osamu
O
Higuchi
Ayuko
A
Miyake
Minoru
M
Ohue
Yukiko
Y
Ohnishi
Hiroaki
H
D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage*; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation; D013280:Stomatitis / Q000188:drug therapy*
D003907:Dexamethasone