Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.
BACKGROUND
Coeliac disease is caused by dietary gluten, which triggers chronic inflammation of the small intestine in genetically predisposed individuals. In one quarter of the patients the disease manifests in the skin as dermatitis herpetiformis. Recently, a novel candidate gene, myosin IXB on chromosome 19p13, was shown to be associated with coeliac disease in the Dutch and Spanish populations. The same gene has previously been associated with inflammatory bowel disease, systemic lupus erythematosus and rheumatoid arthritis risk, making myosin IXB a potential shared risk factor in these inflammatory disorders.


METHODS
In this study, previously reported myosin IXB variants were tested for genetic linkage and association with coeliac disease in 495 Hungarian and Finnish families and in an additional 270 patients and controls.


CONCLUSIONS
The results show significant linkage (logarithm of odds (LOD) 3.76, p = 0.00002) to 19p13 which supports the presence of a genuine risk factor for coeliac disease in this locus. Myosin IXB variants were not associated with coeliac disease in this study; however, weak evidence of association with dermatitis herpetiformis was found. The association could not explain the strong linkage seen in both phenotypes, indicating that the role of other neighbouring genes in the region cannot be excluded. Therefore, more detailed genetic and functional studies are required to characterise the role of the myosin IXB gene in both coeliac disease and dermatitis herpetiformis.
Koskinen
L L E
LL
Department of Medical Genetics, and Research Programo f Molecular Medicine, University of Helsinki, Finland.
Korponay-Szabo
I R
IR
Viiri
K
K
Juuti-Uusitalo
K
K
Kaukinen
K
K
Lindfors
K
K
Mustalahti
K
K
Kurppa
K
K
Adány
R
R
Pocsai
Z
Z
Széles
G
G
Einarsdottir
E
E
Wijmenga
C
C
Mäki
M
M
Partanen
J
J
Kere
J
J
Saavalainen
P
P
D000483:Alleles; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000235:genetics*; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005983:Glutens / Q000009:adverse effects; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D006814:Hungary; D015212:Inflammatory Bowel Diseases / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D009218:Myosins / Q000235:genetics*; D012307:Risk Factors
C113469:myosin IXB; D005983:Glutens; D009218:Myosins