title: Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
abstract: This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.
authors: Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. zhijian_zhao@merck.com
authors: Zhijian
authors: Z
authors: Zhao
authors: Scott E
authors: SE
authors: Wolkenberg
authors: Philip E J
authors: PE
authors: Sanderson
authors: Meiqing
authors: M
authors: Lu
authors: Vandna
authors: V
authors: Munshi
authors: Gregory
authors: G
authors: Moyer
authors: Meizhen
authors: M
authors: Feng
authors: Anthony V
authors: AV
authors: Carella
authors: Linda T
authors: LT
authors: Ecto
authors: Lori J
authors: LJ
authors: Gabryelski
authors: Ming-Tain
authors: MT
authors: Lai
authors: Sridar G
authors: SG
authors: Prasad
authors: Youwei
authors: Y
authors: Yan
authors: Georgia B
authors: GB
authors: McGaughey
authors: Michael D
authors: MD
authors: Miller
authors: Craig W
authors: CW
authors: Lindsley
authors: George D
authors: GD
authors: Hartman
authors: Joseph P
authors: JP
authors: Vacca
authors: Theresa M
authors: TM
authors: Williams
mesh_terms: D018360:Crystallography, X-Ray; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D009154:Mutation; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007211:Indoles; D018894:Reverse Transcriptase Inhibitors; D013449:Sulfonamides; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase