A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement.
A 52-year-old woman was admitted to our hospital with progressive dysphagia. Upper gastrointestinal endoscopy revealed esophageal stenosis and computed tomographic scan revealed symmetrical wall thickness of the thoracic esophagus. Biopsies findings from a lesion were unremarkable. However, a definitive diagnosis of Wegener's granulomatosis was based on positive anti-neutrophil cytoplasmic antibodies directed against proteinase 3 and otorhinolaryngological manifestations. Esophageal complications are rarely reported in Wegener's granulomatosis; however, clinicians should be aware of the possibility of esophageal involvement.
Yamaguchi
Toshimasa
T
Department of Internal Medicine, Osaka City Juso Hospital, 2-12-27 Nonaka-kita, Yodogawa-ku, Osaka, 532-0034, Japan. toshimasa1@excite.co.jp
Yoshioka
Katsunobu
K
Ueda
Mami
M
Morikawa
Takashi
T
Yamagami
Keiko
K
Konishi
Yoshio
Y
Sato
Toshihiko
T
Kawasaki
Yasuko
Y
Imanishi
Masahito
M
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003680:Deglutition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018450:Disease Progression; D004940:Esophageal Stenosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004947:Esophagus / Q000473:pathology*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D053146:Myeloblastin / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D053146:Myeloblastin