[The investigations of the role of toll-like receptors (TLR) in host response to parasitic infection on the current background regarding TLR in mammals and the model nematode Caenorhabditis elegans].
Toll-like receptors (TLRs) are amongst the most highly conserved in the evolution of receptor family, being found in both immune and other cells. TLRs were observed in vascular endothelial cells, epithelial cells, microglia cells, adipocytes, and intestinal and renal cells. TLRs plays a key role in the innate immune response to a variety of pathogens. At present, very little is known about the role of TLRs in host defense against parasitic pathogen infections. The first study shows that TLRs contribute to both innate and adaptive immune responses following infection with protozoan parasite Leishmania major. The TLRs recognizing PAMPs associated with the parasite L. major are essential for the activation of the innate and adaptive immune responses to infection. A study concerning recognition of the role of TLRs in the host-parasite relationship would be an interesting challenge for future study.
Wojtkowiak
Agnieszka
A
Katedra i Zakład Biologii i Parazytologii Lekarskiej, Uniwersytet Medyczny im. Karola Marcinkowskiego, ul. Fredry 10, 61-701 Poznań. agawojtk@wp.pl
D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology*; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D018320:Leishmania major / Q000502:physiology*; D008322:Mammals / Q000276:immunology / Q000469:parasitology*; D051379:Mice; D010273:Parasitic Diseases, Animal / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors