title: Splenic infarction due to concomitant hereditary spherocytosis and sickle cell trait.
abstract: Concomitant hereditary spherocytosis and sickle cell trait, although extremely rare, could potentially lead to splenic sequestration or infarction. We report here the first case of splenic infarction in a child with hereditary spherocytosis and sickle cell trait while flying on a commercial aircraft. The presence of hypoxia, hemoconcentrated erythrocytes, and sickle hemoglobin created the perfect environment for clinical sequelae.
authors: Department of Pediatric Hematology/Oncology, NYU School of Medicine, New York, NY 10016, USA. yatesr01@med.nyu.edu
authors: Robin Yates
authors: RY
authors: Dulman
authors: George R
authors: GR
authors: Buchanan
authors: Howard
authors: H
authors: Ginsburg
authors: Nancy R
authors: NR
authors: Fefferman
authors: M Alba
authors: MA
authors: Greco
authors: Dariusz
authors: D
authors: Borys
authors: Francine
authors: F
authors: Blei
mesh_terms: D001707:Biopsy, Needle; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D018570:Risk Assessment; D012720:Severity of Illness Index; D012805:Sickle Cell Trait / Q000150:complications* / Q000175:diagnosis; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000175:diagnosis; D013156:Splenectomy / Q000379:methods; D013159:Splenic Infarction / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome