title: [Genotype analysis of CYP1A2 IVS4 + 43A/G in patients with prostate cancer].
abstract: OBJECTIVE
  To investigate the genotype of the single nucleotide polymorphisms(SNP) of CYP1A2 IVS4 + 43A/G in patients with prostate cancer by TaqMan allelic discrimination.
  
  
  METHODS
  TaqMan SNP allelic discrimination was performed with the ABI 7300 system to detect the genotype of CYP1A2 IVS4 + 43A/G in 85 patients with prostate cancer.
  
  
  RESULTS
  The genotypes of CYP1A2 IVS4 + 43A/G in the patients were as follows: AA subtype in 5 cases (5.9%), AG in 33 (38.8%), and GG in 47 (55.3%). Each subtype of CYP1A2 IVS4 + 43A/G was not correlated with the Gleason score of prostate cancer.
  
  
  CONCLUSIONS
  There was no significant correlation between SNP of CYP1A2 and the differentiation of prostate cancer.
authors: Department of Urology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
authors: Jing-ping
authors: JP
authors: Ge
authors: Wu
authors: W
authors: Wei
authors: Xue-jun
authors: XJ
authors: Shang
authors: Zheng-yu
authors: ZY
authors: Zhang
authors: Song
authors: S
authors: Xu
authors: Dong
authors: D
authors: Wang
authors: Jian-ping
authors: JP
authors: Gao
mesh_terms: D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D019388:Cytochrome P-450 CYP1A2