Adventures in drug disposition: pas seulement pâté de foie.
Interindividual variability in drug disposition and effect has served to confound the optimization of drug therapy. Over my career, I have focused on delineating mechanisms that contribute to this variability, with the goal of improving the benefit : risk ratio when drug therapy is chosen as an intervention strategy. In this manuscript, I present some of our experimental findings that I believe have contributed to an increased understanding of variability in drug disposition and efficacy.
Sitar
Daniel S
DS
Department of Pharmacology and Therapeutics, Faculty of Medicine, Centre on Aging, University of Manitoba, A220-753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada. sitar@cc.umanitoba.ca
D000818:Animals; D005853:Geriatrics / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical / Q000266:history*