Input of DNA microarrays to identify novel mechanisms in multiple myeloma biology and therapeutic applications.
Multiple myeloma is a B-cell neoplasia characterized by the proliferation of a clone of malignant plasma cells in the bone marrow. We review here the input of gene expression profiling of myeloma cells and of their tumor microenvironment to develop new tumor classifiers, to better understand the biology of myeloma cells, to identify some mechanisms of drug sensitivity and resistance, to identify new myeloma growth factors, and to depict the complex interactions between tumor cells and their microenvironment. We discuss how these findings may improve the clinical outcome of this still incurable disease.
Mahtouk
Karène
K
CHU Montpellier, Institut de Recherche en Biothérapies, Hôpital Saint-Eloi, Montpellier, France.
Hose
Dirk
D
De Vos
John
J
Moreaux
Jérôme
J
Jourdan
Michel
M
Rossi
Jean François
JF
Rème
Thierry
T
Goldschmidt
Harmut
H
Klein
Bernard
B
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D009101:Multiple Myeloma / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis