In search of novel treatments for peripheral neuropathies and nerve regeneration.
Currently, we do not have effective therapies aimed at preventing or reversing axonal degeneration seen in peripheral neuropathies. Drug development programs should be aimed at understanding mechanisms of distal axonal degeneration and take into account the critical role Schwann cells play in axonal maintenance and nerve regeneration.
Höke
Ahmet
A
Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. ahoke@jhmi.edu
Mi
Ruifa
R
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000473:pathology*; D012583:Schwann Cells / Q000378:metabolism / Q000502:physiology