title: [Two cases of advanced low rectal cancer, preoperative chemo-radiation therapy leading to complete histological response].
abstract: We report two cases of advanced low rectal cancer, with preoperative chemo-radiation therapy leading to a complete histological response. Case 1 was a 74-year-old male who was diagnosed as advanced low rectal cancer. Preoperative chemo-radiation (a total of 45 Gy radiation+oral 5'-DFUR 800 mg/day for 3 weeks) was performed. Then, 30 days after chemo-radiation, we conducted a low anterior resection with lymph node dissection. Histological examination revealed no residual cancer cells in the resected specimen. Case 2 was a 35-year-old male who was diagnosed as advanced low rectal cancer. Preoperative chemo-radiation (a total of 45 Gy radiation+5-FU 500 mg/day+CDDP 10 mg/day for 3 weeks) was performed. 28 days after chemo-radiation, we conducted an abdominoperineal resection with lymph node dissection and a partial resection of the liver. Histological examination revealed well-differentiated adenocarcinoma in the resected liver tissue, but a rectal tumor was replaced by scar tissue with no viable cells.
authors: Dept. of Surgery, Mitoyo General Hospital.
authors: Tetsunobu
authors: T
authors: Udaka
authors: Hirotaka
authors: H
authors: Fujita
authors: Masaru
authors: M
authors: Jida
authors: Naohisa
authors: N
authors: Waki
authors: Masatoshi
authors: M
authors: Kubo
authors: Osanori
authors: O
authors: Sogabe
authors: Hiroya
authors: H
authors: Maeda
authors: Minoru
authors: M
authors: Mizuta
authors: Kazutoyo
authors: K
authors: Shirakawa
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*
chemical_list: D005472:Fluorouracil