title: Systemic family therapy in schizophrenia: a randomized clinical trial of effectiveness.
abstract: BACKGROUND
  Although evidence suggests the effectiveness of cognitive and behaviorally oriented family therapies for schizophrenia, no specific randomized study has been carried out on Systemic Family Therapy (SFT). The purpose of this longitudinal prospective study was to evaluate the clinical effectiveness of SFT in the treatment of patients suffering from schizophrenia, as compared with a control case sample composed of patients undergoing routine psychiatric treatment. The study included a 2-year follow-up period and was conducted following the Milan School model.
  
  
  METHODS
  The case sample in the study was made up of 20 patients treated with SFT associated with routine psychiatric treatment, and 20 patients undergoing routine psychiatric treatment alone. Both groups of patients were re-evaluated at the end of treatment (T1) and 12 months after the end of treatment (T2) to assess the clinical course of the illness.
  
  
  RESULTS
  At the end of the follow-up period, we noticed an improved clinical course and a better pharmacological compliance in the group of patients treated with SFT. In the experimental case sample, 3 subjects (15%) had relapsed, compared to 13 patients (65%) in the control group (p = 0.03). No significant difference was found in the 2nd year of follow-up.
  
  
  CONCLUSIONS
  Our study provides an innovative contribution with regard to the evaluation of the clinical effectiveness of SFT in the treatment of schizophrenic patients. The clinical results were significant, and we thus feel justified in continuing to use this type of therapy in integrated interventions involving schizophrenic patients.
authors: Psychiatric Clinic, Milan State University, Fondazione IRCCS, Ospedale Maggiore Policlinico, Milan, Italy. cinzia.bressi@unimi.it
authors: Cinzia
authors: C
authors: Bressi
authors: Stefano
authors: S
authors: Manenti
authors: Patrizia
authors: P
authors: Frongia
authors: Matteo
authors: M
authors: Porcellana
authors: Giordano
authors: G
authors: Invernizzi
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D003142:Communication; D005196:Family Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D010349:Patient Compliance / Q000523:psychology; D010353:Patient Education as Topic; D010865:Pilot Projects; D011340:Problem Solving; D011446:Prospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000628:therapy*; D012565:Schizophrenic Psychology; D016037:Single-Blind Method; D013598:Systems Theory; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents