title: Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives.
abstract: A small library of simple 1,4-disubstituted 1,2,3-triazoles was prepared using a known one-pot procedure starting from organic halides and terminal alkynes. The compounds were then tested for their antibacterial activity against normal and resistant species of Staphylococcus aureus.
authors: Unité de Pharmacologie Chimique et Génétique UMR8151 CNRS / U640 INSERM, Paris, France.
authors: Marie
authors: M
authors: Aufort
authors: Jean
authors: J
authors: Herscovici
authors: Pascale
authors: P
authors: Bouhours
authors: Nicole
authors: N
authors: Moreau
authors: Christian
authors: C
authors: Girard
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D054852:Small Molecule Libraries; D014230:Triazoles