title: A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds.
abstract: BACKGROUND
  In this study, we examined Radiesse (calcium hydroxylapatite; CaHA), Juvederm 24 (hyaluronic acid; HA-1A), Juvederm 24HV (HA-1B), and Perlane (HA-2) for patient satisfaction, likelihood to return, immediate efficacy, and duration of correction.
  
  
  OBJECTIVE
  This multicenter, blinded, randomized study compares patient satisfaction variables, efficacy, and durability of CaHA gel and HA for correction of nasolabial folds (NLFs) through 12 months after 4-month touch-up.
  
  
  METHODS
  A total of 205 randomized patients received either CaHA gel or HA for NLF treatment at initial visit and 4-month touch-up. Patients returned at 4, 8, and 12 months after the second injection for evaluation. Surveys measured patient satisfaction; effectiveness measures included the Global Aesthetic Improvement Scale (GAIS).
  
  
  RESULTS
  More CaHA gel patients were satisfied or extremely satisfied than each HA tested. At 8 months, significantly more CaHA gel-treated NLFs were improved on the GAIS than any HA. The volumes of CaHA gel and three HA materials injected through 4 months were 2.2, 2.9, 4.8, and 2.9 mL, respectively (p<.005). No serious adverse events were observed.
  
  
  CONCLUSIONS
  In this controlled study, CaHA gel ranked highest in patient satisfaction and likelihood to return. The material was more effective and longer lasting than each HA in maintaining NLF augmentation.
authors: Private Clinic, Hautok, Munich, Germany. DrMarion@hautok.de
authors: Marion
authors: M
authors: Moers-Carpi
authors: Stephan
authors: S
authors: Vogt
authors: Begonia Martinez
authors: BM
authors: Santos
authors: Jorge
authors: J
authors: Planas
authors: Sonia Rovira
authors: SR
authors: Vallve
authors: David J
authors: DJ
authors: Howell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003357:Cosmetic Techniques; D017886:Durapatite / Q000008:administration & dosage*; D005145:Face; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D006820:Hyaluronic Acid; D017886:Durapatite