Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates.
With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad functional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.
Roy
Vincent
V
Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.
Kumamoto
Hiroki
H
Berteina-Raboin
Sabine
S
Nolan
Steven P
SP
Topalis
Dimitri
D
Deville-Bonne
Dominique
D
Balzarini
Jan
J
Neyts
Johan
J
Andrei
Gracelia
G
Snoeck
Robert
R
Agrofoglio
Luigi A
LA
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002384:Catalysis; D009705:Nucleosides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*
D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates; D012428:Ruthenium