Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns.
A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used. AMG pharmacokinetics present a strong interindividual and intraindividual variability in neonates; in the premature neonate AMG clearance is reduced and the half-life is longer, leading to higher serum trough concentrations. Neonates may require therapeutic drug monitoring (TDM) and a "tailored" therapeutic regimen. The aim of this work is to present our personal experience wtih TDM of gentamicin in 68 newborns and to compare it with data available in the literature.
Testa
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Istituto di Patologia e Terapia Intesiva Neonatale-Puericultura e Nido-Università de Cagliari, Italy.
Fanos
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Martinelli
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Stronati
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Mussap
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Del Zompo
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D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D001724:Birth Weight; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D010878:Piperacillin / Q000008:administration & dosage; D018805:Sepsis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010878:Piperacillin