Proteomic diagnosis of Sjögren's syndrome.
In the last few years, a growing interest has arisen in the application of proteomic analysis to rheumatic disease. Sjögren's syndrome is a systemic disease that affects exocrine glands directly, and is therefore expected to influence the composition of the whole human saliva and lachrymal fluid. Therefore, a rising number of studies have been performed in an attempt to characterize the salivary and lachrymal protein profiles of patients with Sjögren's syndrome by using a proteomic approach. This review summarizes the state of the art and the potential application of proteomics in the systematic search for diagnostic biomarkers in Sjögren's syndrome.
Giusti
Laura
L
University of Pisa, Department of Psychiatry, Neurobiology, Pharmacology & Biotechnology, Via Bonanno 6, 56126 Pisa, Italy. giusti@farm.unipi.it
Baldini
Chiara
C
Bazzichi
Laura
L
Bombardieri
Stefano
S
Lucacchini
Antonio
A
D015415:Biomarkers / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D007765:Lacrimal Apparatus / Q000378:metabolism; D010306:Parotid Gland / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D012219:Rheumatology / Q000379:methods*; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers