title: Chronic atrial fibrillation ablation impact on endocrine and mechanical cardiac functions.
abstract: OBJECTIVE
  Assess the impact of persistent/permanent atrial fibrillation (AF) ablation on endocrine and mechanical cardiac functions.
  
  
  RESULTS
  In all, 43 patients (40 males, 53 +/- 12 years) undergoing persistent/permanent AF ablation had atrial (ANP) and brain natriuretic peptide (BNP) measurements before day 1, 3, and 3 months after ablation. In the same period of time transthoracic echocardiography was performed. With a mean radiofrequency delivery of 98 +/- 29 min, sinus rhythm (SR) was restored in 30 patients (70%) without DC shock. ANP decreased significantly (P < 0.001) with restoration of SR and then increased until day 3 post ablation without reaching the level observed during AF. At 3 months, ANP was significantly lower than day 3 reaching normal value in 28 (65%) patients and being <7 pg/mL in 4 (9%). The BNP followed the same trend with normal BNP level in 23 (53%) patients at 3 months. Identifiable atrial filling waves on the pulsed Doppler transmitral recordings performed between day 2 and day 4 after the procedure were seen in 18 patients (42%). At 3 months, 39 (95%) of the patients with SR during echocardiography had a significant A wave.
  
  
  CONCLUSIONS
  SR following persistent/permanent AF ablation is associated with a dramatic decrease in natriuretic peptides. At 3 months, despite relatively extensive atrial ablation, endocrine and mechanical cardiac functions are significantly improved.
authors: Service de Rythmologie, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux/Université Bordeaux II, Bordeaux-Pessac, France. frederic.sacher@chu-bordeaux.fr <frederic.sacher@chu-bordeaux.fr>
authors: Frédéric
authors: F
authors: Sacher
authors: Jean-Benoît
authors: JB
authors: Corcuff
authors: Philippe
authors: P
authors: Schraub
authors: Valérie
authors: V
authors: Le Bouffos
authors: Agnès
authors: A
authors: Georges
authors: Samuel O
authors: SO
authors: Jones
authors: Stéphane
authors: S
authors: Lafitte
authors: Pierre
authors: P
authors: Bordachar
authors: Mélèze
authors: M
authors: Hocini
authors: Jacques
authors: J
authors: Clémenty
authors: Michel
authors: M
authors: Haissaguerre
authors: Laurence
authors: L
authors: Bordenave
authors: Raymond
authors: R
authors: Roudaut
authors: Pierre
authors: P
authors: Jaïs
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D016275:Atrial Function; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D017115:Catheter Ablation; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D019210:Troponin I / Q000378:metabolism
chemical_list: D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor