[Molecular pharmacogenetics in hospital laboratories in France: current data and future prospects].
Molecular pharmacogenetic units have recently been established in several hospital laboratories in France. The clinical impact of these units is still limited and numerous problems of organizational, ethical, legal, technical, social and economical nature remain to be resolved. However, an increasing number of these units, a rise in their activities and an enlargement of their scope of application are foreseeable in the future. Ultimately, these units would significantly contribute to limit the public health problem caused by interindividual variabilities in drug effects. In view of these prospects, it seems essential that such hospital activity should be quickly recognised by the authorities and the various health sectors in France. It is also essential that the problems that arise from such pharmacogenetic activities should be considered by the authorities and would profit from the organization of a national network and from financial guarantees.
Allorge
D
D
Unité de Génopathies et de Pharmacotoxicogénétique, Laboratoire de Biochimie et Biologie Moléculaire de l'Hôpital Calmette, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France.
Beaune
P-H
PH
Becquemont
L
L
Bessard
G
G
Bezieau
S
S
Boisdron-Celle
M
M
Boyer
J-C
JC
Broly
F
F
Dhaneens
C-M
CM
Fonrose
X
X
Gagnieu
M-C
MC
Gamelin
E
E
Gozé
C
C
Jacqz-Aigrain
E
E
Loric
S
S
Loriot
M-A
MA
Marquet
P
P
Morel
A
A
Namour
B
B
Paintaud
G
G
Peoc'h
K
K
Picard
N
N
Watier
H
H
Verstuyft
C
C
D064420:Drug-Related Side Effects and Adverse Reactions; D005602:France; D006801:Humans; D007755:Laboratories, Hospital / Q000941:ethics / Q000706:statistics & numerical data / Q000639:trends*; D008780:Methyltransferases / Q000172:deficiency / Q000235:genetics; D010597:Pharmacogenetics / Q000941:ethics / Q000706:statistics & numerical data / Q000639:trends*; D011634:Public Health
D008780:Methyltransferases; C022745:thiopurine methyltransferase