title: Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin.
abstract: Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
authors: University of Texas at Austin College of Pharmacy, UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
authors: Jason M
authors: JM
authors: Cota
authors: Jodi L
authors: JL
authors: Grabinski
authors: Robert L
authors: RL
authors: Talbert
authors: David S
authors: DS
authors: Burgess
authors: P David
authors: PD
authors: Rogers
authors: Thomas D
authors: TD
authors: Edlind
authors: Nathan P
authors: NP
authors: Wiederhold
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000077336:Caspofungin; D002686:Chitin / Q000378:metabolism*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D002686:Chitin; D020928:Mitogen-Activated Protein Kinases; D000077336:Caspofungin