title: Effect of preload reduction on sonographic myocardial integrated backscatter.
abstract: OBJECTIVE
  Sonographic myocardial tissue characterization with integrated backscatter (IBS) is affected by both structural and functional properties of the myocardium. The aim of the present study was to investigate the effect of preload reduction by hemodialysis (HD) on IBS measurements.
  
  
  METHODS
  Fifty-two patients on maintenance HD underwent echocardiography before and after a routine HD session. Measurements included the variation of IBS during the cardiac cycle (CV-IBS) and calibrated IBS (cal-IBS).
  
  
  RESULTS
  After HD, there were significant reductions in left ventricular end-diastolic and end-systolic dimensions and left atrial diameter. There was a reduction in stroke volume and LV ejection fraction consistent with a reduction in preload. Furthermore, CV-IBS was significantly lower after HD (7.9 +/- 2.2 versus 6.9 +/- 1.8 dB, 7.0 +/- 2.1 versus 6.2 +/- 1.9 dB, and 9.0 +/- 2.6 versus 8.1 +/- 2.0 dB [p < 0.01], respectively, in the left anterior, lateral, and inferior wall of the ventricle). Cal-IBS remained unchanged after dialysis compared with baseline. CV-IBS and ultrafiltration volume were significantly correlated.
  
  
  CONCLUSIONS
  HD leads to a decrease in CV-IBS that appears to be preload-dependent. This finding is in concordance with diminished left ventricular performance during HD.
authors: Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland.
authors: Andrzej
authors: A
authors: Minczykowski
authors: Danuta
authors: D
authors: Zaremba-Drobnik
authors: Irena
authors: I
authors: Pietrzak
authors: Stanislaw
authors: S
authors: Czekalski
authors: Henryk
authors: H
authors: Wysocki
mesh_terms: D001783:Blood Flow Velocity; D001810:Blood Volume; D015150:Echocardiography, Doppler / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007676:Kidney Failure, Chronic / Q000628:therapy; D015588:Observer Variation; D006435:Renal Dialysis; D015203:Reproducibility of Results; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left