The thyroid dose burden in medical imaging A re-examination.
Radiation is the best defined causative factor in thyroid cancer. The thyroid is especially susceptible to injury from radiation to which it may be exposed in a variety of circumstances in addition to natural background: radiotherapy, including, historically, therapy of such benign conditions as ring worm and haemangiomata, radiation exposure in nuclear accidents and fallout from nuclear bomb tests, and diagnostic exposures, particularly in the relatively high dose CT examination of head and neck. Both use of CT and the incidence of thyroid cancer appear to be increasing worldwide and it has been suggested that there may be a causative relationship between the two. It has been further posited that the iodine content of the thyroid might play a role in increasing the radiation dose absorption. Indeed, on the same basis, iodine administered in the form of an X-ray contrast-enhancing agent might also be expected to play some role in increasing thyroid radiation absorption resulting in a yet higher dose burden in any give circumstances than is generally assumed. In view of the importance of these ideas we have performed some calculations to estimate the magnitude of the iodine effects. We conclude that they are not great enough to cause concern.
Dawson
Peter
P
Department of Imaging, UCL Hospitals, London, United Kingdom. peter.dawson@uclh.nhs.uk
Punwani
Shonit
S
D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000503:physiopathology*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed / Q000009:adverse effects*