title: The effects of bromazepam on the early stage of visual information processing (P100).
abstract: The early stages of visual information processing, involving the detection and perception of simple visual stimuli, have been demonstrated to be sensitive to psychotropic agents. The present study investigated the effects of an acute dose of bromazepam (3 mg), compared with placebo, on the P100 component of the visual evoked potential and reaction time. The sample, consisting of 14 healthy subjects (6 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Results suggest that bromazepam (3 mg) impairs the initial stage of visual information processing, as observed by an increase in P100 latency.
authors: Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás 71, Rio de Janeiro, RJ, Brazil. fernandapuga@globo.com
authors: Fernanda
authors: F
authors: Puga
authors: Isabel
authors: I
authors: Sampaio
authors: Heloisa
authors: H
authors: Veiga
authors: Camila
authors: C
authors: Ferreira
authors: Maurício
authors: M
authors: Cagy
authors: Roberto
authors: R
authors: Piedade
authors: Pedro
authors: P
authors: Ribeiro
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001960:Bromazepam / Q000494:pharmacology*; D004594:Electrophysiology; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D010919:Placebos; D001960:Bromazepam