Serum troponin in neonatal intensive care.
Cardiac troponins have a major role in screening and diagnosis of myocardial ischaemia in adults and children. Their introduction has redefined the diagnosis of myocardial infarction in adults and provided valuable prognostic information. In the paediatric population, troponins show a good correlation with the extent of myocardial damage following cardiac surgery and cardiotoxic medication, and can be used as predictors of subsequent cardiac recovery and mortality. This review discusses the current established reference values in term and preterm infants and demonstrates their potential use in neonatology. They may serve as a useful adjunct in the assessment of the magnitude of myocardial injury in respiratory distress syndrome and asphyxia. They may also benefit centres without on-site echocardiography with some evidence showing good correlation with echo-derived markers of myocardial function. The use of troponins in the neonatal unit remains a research tool. More work is needed to explore their prognostic role and monitoring response to treatment following cardioprotective strategies. In preterm infants the effect of inotropes on myocardial function needs further study and troponin may form an integral part of this research.
El-Khuffash
Afif F
AF
Department of Neonatology, National Maternity Hospital, Dublin, Ireland. afif_faisal@hotmail.com
Molloy
Eleanor J
EJ
D001238:Asphyxia Neonatorum / Q000097:blood / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000503:physiopathology*; D004452:Echocardiography; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000503:physiopathology; D014336:Troponin / Q000097:blood*
D015415:Biomarkers; D014336:Troponin