title: Regulation of cyclization for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydrooxepines.
abstract: Dramatic solvent effect is observed during the cyclization of 1. Synthesis of 2 is achieved from the reaction of 1 with a hexamethylditin-catalyzed palladium complex followed by aldehydes in the presence of TMSOTf in THF, whereas 3 is formed in CH2Cl2. The method described herein is successful with various substrates 1 in good yields and high levels of diastereoselectivity.
authors: BK-21 School of Chemical Materials Science and Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
authors: Sang-Hoon
authors: SH
authors: Kim
authors: Seung-Ju
authors: SJ
authors: Oh
authors: Pil-Su
authors: PS
authors: Ho
authors: Sin-Cheol
authors: SC
authors: Kang
authors: Kyung-Jin
authors: KJ
authors: O
authors: Chan-Mo
authors: CM
authors: Yu