Positive end-expiratory pressure in acute respiratory distress syndrome: should the 'open lung strategy' be replaced by a 'protective lung strategy'?
In patients with acute respiratory distress syndrome, positive end-expiratory pressure is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume. The best positive end-expiratory pressure should correspond to the best compromise between recruitment and distension, a condition that coincides with the best respiratory elastance.
Rouby
Jean-Jacques
JJ
Réanimation Chirurgicale Polyvalente Pierre Viars, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris - 6, 47/83 boulevard de l'Hôpital, Paris Cédex 13, France. jjrouby.pitie@invivo.edu
Ferrari
Fabio
F
Bouhemad
Bélaïd
B
Lu
Qin
Q
D000818:Animals; D006801:Humans; D008168:Lung / Q000502:physiology*; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology