Update on the pathogenesis of post-transplant skin cancer in renal transplant recipients.
Remarkable advances in the field of transplantation over the last several decades have benefited many thousands of patients. Five-year survival ranges from 90% for a live donor renal transplant to 85% for a cadaveric renal transplant. However, with this success come the complications of chronic immunosuppression. Lifelong immunosuppressive treatment for adequate graft function results in reduction of immunosurveillance, with increased risk of various cancers leading to substantial morbidity and mortality in these patients. This review discusses multifactorial intrinsic and extrinsic factors contributing to the pathogenesis of skin cancers in renal transplant recipients and reviews potential solutions.
Ho
W L
WL
Department of Dermatology, Beaumont Hospital, Dublin 9, Ireland. drwlho@yahoo.com
Murphy
G M
GM
D000328:Adult; D000367:Age Factors; D002280:Basal Cell Carcinoma / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D009154:Mutation; D030361:Papillomavirus Infections / Q000209:etiology; D011183:Postoperative Complications / Q000517:prevention & control; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*; D014466:Ultraviolet Rays / Q000009:adverse effects
D007166:Immunosuppressive Agents