title: A mathematical model of pH(i) regulation in central CO2- chemoreception.
abstract: In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH(i)) while in non-chemosensitive neurons pH(i) recovery is observed. The precise mechanisms for the differential regulation of pH(i) recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pH(i) regulation in central CO2 chemoreception.
authors: State University of New York at Stony Brook, Department of Physiology and Biophysics, USA. jcordove@ic.sunysb.edu
authors: Juan M
authors: JM
authors: Cordovez
authors: Chris
authors: C
authors: Clausen
authors: Leon C
authors: LC
authors: Moore
authors: Irene C
authors: IC
authors: Solomon
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000503:physiopathology; D008526:Medulla Oblongata / Q000502:physiology*; D023421:Models, Animal; D008959:Models, Neurological
chemical_list: D002245:Carbon Dioxide