[Comparative study of the effects of new fluorine-containing pinacidyl analogs on bladder contractile function and vessel tone].
The effects of four new fluorine-containing pinacidyl analogs (FPs) on the bladder contractile function in vitro and in vivo, and on the vessel tone in vitro were examined. All the four drugs produced a concentration-dependent relaxation of isolated rat detrusor strips and isolated aorta rings. The contractility inhibition effect of compound FP-5 was decreased by preliminary glibenclamide perfusion. This compound also effectively inhibited bladder contractility function in vivo.
Mokhort
N A
NA
Samarskaia
I V
IV
Iagupol'skaia
L M
LM
D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D005260:Female; D005461:Fluorine / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D049990:Membrane Transport Modulators / Q000737:chemistry / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000737:chemistry; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*
D000814:Aniline Compounds; D006146:Guanidines; D049990:Membrane Transport Modulators; C526129:PF-5 compound; D015221:Potassium Channels; D005461:Fluorine; D020110:Pinacidil