title: Comparison of histopathologic-clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases.
abstract: OBJECTIVE
  We sought to identify criteria able to distinguish between Jessner's lymphocytic infiltration of the skin (JLIS) and lupus erythematosus tumidus (LET).
  
  
  METHODS
  The following characteristics were recorded in a retrospective, multicenter analysis of patients with JLIS and LET: clinical features (number, size, type, and localization of lesions; photosensitivity; extracutaneous signs), histologic findings, phototesting, lupus serology, treatment, and outcome. Available histologic slides were reviewed blinded to the initial diagnosis using a pre-established grid.
  
  
  RESULTS
  Univariate analysis of data from patients with JLIS (15 women, 17 men; mean age: 35 years) and LET (13 women, one man; mean age: 31 years) showed the following significant (P < .05) differences: more frequent back involvement and annular lesions in JLIS, as opposed to female predominance, more frequent face involvement, and plaques in LET. Phototesting, especially ultraviolet B, induced lesions in 18 of 26 patients with JLIS and all 4 with LET. The blinded histologic review (33 samples) only found slight epidermal atrophy and focal thickened dermoepidermal junction more frequent and perivascular lymphocyte infiltrations less dense in LET. The two groups of patients reclassified according histopathologic features (18 LET and 11 JLIS) showed only slight clinical differences (more frequent nasal bridge lesions in LET and annular lesions in JLIS).
  
  
  CONCLUSIONS
  The retrospective nature of the study is a limitation.
  
  
  CONCLUSIONS
  JLIS and LET in this population showed more similarities than differences, supporting a continuous spectrum covering these two entities.
authors: Service de Dermatologie, Hôpital Robert-Debré, Centre Hospitalier de Reims, Reims, France.
authors: Valérie
authors: V
authors: Rémy-Leroux
authors: Fabienne
authors: F
authors: Léonard
authors: Daniel
authors: D
authors: Lambert
authors: Janine
authors: J
authors: Wechsler
authors: Bernard
authors: B
authors: Cribier
authors: Pierre
authors: P
authors: Thomas
authors: Henri
authors: H
authors: Adamski
authors: Marie-Claude
authors: MC
authors: Marguery
authors: François
authors: F
authors: Aubin
authors: Dominique
authors: D
authors: Leroy
authors: Philippe
authors: P
authors: Bernard
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D010787:Photosensitivity Disorders / Q000188:drug therapy / Q000473:pathology*; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000962:Antimalarials