title: Testicular development in growth-retarded mice.
abstract: To assess delayed fertility in male growth-retarded (grt) mice with congenital primary hypothyroidism, their testes were chronologically examined. The testicular weight in grt mice was significantly lower than age-matched normal mice until 8 weeks but was comparable at 13 and 26 weeks. While normal mice had mature sperm cells in both testes and epididymides at 5 weeks, age-matched grt mice did not. The size of the seminiferous tubules in testes of grt mice was smaller than that of normal mice before 13 weeks but was comparable at 26 weeks. These findings suggest that male grt mice might need more than 13 weeks to develop mature testes.
authors: National Institute of Occupational Safety and Health, Kawasaki, Kanagawa, Japan.
authors: Kenichi
authors: K
authors: Kobayashi
authors: Hisayo
authors: H
authors: Kubota
authors: Junzo
authors: J
authors: Saegusa
mesh_terms: D000818:Animals; D003409:Congenital Hypothyroidism / Q000503:physiopathology / Q000662:veterinary; D006130:Growth Disorders / Q000662:veterinary*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size; D012376:Rodent Diseases / Q000503:physiopathology*; D012671:Seminiferous Tubules / Q000254:growth & development; D013737:Testis / Q000166:cytology / Q000254:growth & development*