Endoplasmic reticulum/mitochondria calcium cross-talk.
The interaction of mitochondria with the endoplasmic reticulum (ER) Ca2+ store plays a key role in allowing these organelles to rapidly and effectively respond to cellular Ca2+ signals. In this contribution, we will briefly discuss: (i) old and new concepts of mitochondrial Ca2+ homeostasis; (ii) the relationship between mitochondrial 3D structure and Ca2+ homeostasis; (iii) the modulation by cytoplasmic signalling pathways; and (iv) new data suggesting that mitochondria and ER Ca2+ channels are assembled in a macromolecular complex in which the inositol-1,4,5-trisphosphate receptor directly stimulates the mitochondrial Ca2+ uptake machinery.
Romagnoli
Anna
A
ER-GenTech and Interdisciplinary Center for the Study of Inflammation, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy.
Aguiari
Paola
P
De Stefani
Diego
D
Leo
Sara
S
Marchi
Saverio
S
Rimessi
Alessandro
A
Zecchini
Erika
E
Pinton
Paolo
P
Rizzuto
Rosario
R
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*
D002118:Calcium