title: Analysis of systematic and genetic effects on the prevalence of primary cataract, persistent pupillary membrane and distichiasis in the two color variants of English Cocker Spaniels in Germany.
abstract: Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e.V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS. There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed.
authors: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
authors: Anja
authors: A
authors: Engelhardt
authors: Kathrin Friederike
authors: KF
authors: Stock
authors: Henning
authors: H
authors: Hamann
authors: Rolf
authors: R
authors: Brahm
authors: Heinrich
authors: H
authors: Grussendorf
authors: Carsten U
authors: CU
authors: Rosenhagen
authors: Ottmar
authors: O
authors: Distl
mesh_terms: D000367:Age Factors; D000818:Animals; D002386:Cataract / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D003116:Color; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D005128:Eye Diseases / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany; D008297:Male; D010375:Pedigree; D015995:Prevalence; D019655:Quantitative Trait, Heritable