Nasopharyngectomy and surgical margin status: a survival analysis.
OBJECTIVE
To explore whether the margin status at surgical salvage nasopharyngectomy for local residual or recurrent nasopharyngeal carcinoma affects patient survival.


METHODS
Retrospective case series review.


METHODS
Academic tertiary referral center.


METHODS
Seventy-nine consecutive patients with operable local residual or recurrent nasopharyngeal carcinoma after failure of primary treatment with radiotherapy with or without chemotherapy underwent surgical salvage nasopharyngectomy with curative intent between November 28, 1987, and November 17, 2003. Sixty-one patients were men and 18 were women. Their mean age was 48 years (age range, 26-70 years).


METHODS
Surgical salvage nasopharyngectomy.


METHODS
The status of the closest margin at surgery was assessed as clear, close, or positive. Survival time was measured from the date of surgery to the date of the last follow-up, to the date of an event occurrence, or to the date of death. The Kaplan-Meier method was used to estimate the probability of local progression-free survival and overall survival at 5 years. Differences in survival rates between surgical margin statuses were assessed using the log-rank test.


RESULTS
Five-year overall survival for patients with clear margins was 77%, for patients with close margins was 46% (P = .05), and for patients with positive margins was 23% (P < .001).


CONCLUSIONS
Clear surgical margins at the time of surgical salvage nasopharyngectomy for residual or recurrent nasopharyngeal carcinoma positively affect patient survival.
Vlantis
Alexander C
AC
Department of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong. lexvlantis@cuhk.edu.hk
Tsang
Raymond K Y
RK
Yu
Brian K H
BK
Kam
Michael K M
MK
Tong
Michael C F
MC
Lo
Phoebe S Y
PS
van Hasselt
C Andrew
CA
D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000401:mortality* / Q000601:surgery; D009666:Nose / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome