title: Amplification of acute focal ischemic deficit by narcotics.
abstract: BACKGROUND
  This article describes two patients with major ischemic stroke symptoms who had extremely small areas of acute brain infarction, suggestive of acute intrahemispheric diaschisis. Both patients were using narcotic analgesics during their stroke, and in both cases the clinical deficits improved dramatically with naloxone.
  
  
  CONCLUSIONS
  We postulate that the narcotics amplified the ischemic stroke symptoms and that this effect was antagonized by naloxone.
  
  
  CONCLUSIONS
  This suggests that the opiate system may be involved in the process of intrahemispheric diaschisis.
authors: Davee Department of Neurology, Feinberg School of Medicine of Northwestern University, 710 North Lake Shore Drive, Abbott Hall, 11th Floor, Chicago, IL 60611, USA.
authors: Jordan
authors: J
authors: Dubow
authors: Richard A
authors: RA
authors: Bernstein
mesh_terms: D000208:Acute Disease; D000368:Aged; D002545:Brain Ischemia / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000009:adverse effects*; D004091:Hydromorphone / Q000009:adverse effects*; D008297:Male; D009270:Naloxone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D009294:Narcotics / Q000009:adverse effects*; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D006853:Hydrocodone; D004091:Hydromorphone