title: Yersinia outer proteins: Yops.
abstract: The pathogenic bacteria Yersinia spp. contain a virulence plasmid that encodes a type III secretion system and effectors. During infection, four of the effectors target the actin cytoskeleton, crippling the phagocytic machinery in the infected cell. The remaining two effectors dampen the innate immune response by targeting important signalling pathways. Although the biochemical activity for each of these effectors is known, the mechanisms involved in their ordered secretion and delivery remain elusive.
authors: Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild Science Building, D300, 299 Campus Drive, Stanford, CA 94305-5124, USA.
authors: Jennifer E
authors: JE
authors: Trosky
authors: Amy D B
authors: AD
authors: Liverman
authors: Kim
authors: K
authors: Orth
mesh_terms: D001426:Bacterial Proteins / Q000633:toxicity*; D002352:Carrier Proteins / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology; D010957:Plasmids; D015398:Signal Transduction / Q000276:immunology; D014774:Virulence; D015007:Yersinia / Q000276:immunology* / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins