title: Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components.
abstract: Heterologous differentiation in adipocytic tumors is a rare phenomenon. Only 4 cases of myxoid liposarcoma (MLS) with cartilaginous differentiation were thus far reported without confirmatory molecular assays. We describe a primary MLS with chondroid differentiation that affected the left thigh of a 47-year-old man. Histologically, multiple sharply demarcated chondroid nodules were embedded among the classic MLS area. By reverse transcription-polymerase chain reaction, the identical type II TLS-CHOP fusion gene transcripts were detected in both the liposarcomatous and microdissected chondroid tumor cells. Our case confirms the actual existence of MLS with cartilaginous differentiation and the neoplastic nature of chondroid component.
authors: Department of Pathology, Kaohsiung Medical Center, Chang Gung University Hospital College of Medicine, Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung County 833, Taiwan.
authors: Yu-Ching
authors: YC
authors: Wei
authors: Chien-Feng
authors: CF
authors: Li
authors: Hock-Liew
authors: HL
authors: Eng
authors: Ming-Chung
authors: MC
authors: Yeh
authors: Ching-Nan
authors: CN
authors: Lin
authors: Hsuan-Ying
authors: HY
authors: Huang
mesh_terms: D000328:Adult; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D013848:Thigh; D051742:Transcription Factor CHOP / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D034702:RNA-Binding Protein FUS; C106030:TLS-CHOP fusion protein, human; D051742:Transcription Factor CHOP