Increased S100B serum levels in dilated cardiomyopathy patients.
BACKGROUND
The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease.


RESULTS
We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426-3591]) were higher than in controls (35 pg/mL [29-55]), P < .001. S100B serum levels were higher in patients group (0.051 microg/L [0.022-0.144]) than in controls (0.017 microg/L [0.003-0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013).


CONCLUSIONS
Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.
Mazzini
Guilherme S
GS
Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil.
Schaf
Débora V
DV
Vinadé
Elsa R
ER
Horowitz
Estela
E
Bruch
Ricardo S
RS
Brunm
Liz M B P
LM
Gonçalves
Carlos A
CA
Bacal
Fernando
F
Souza
Diogo O
DO
Portela
Luis V C
LV
Bordignon
Solange
S
D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009414:Nerve Growth Factors / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D011498:Protein Precursors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012720:Severity of Illness Index; D013318:Stroke Volume
D015415:Biomarkers; D009414:Nerve Growth Factors; D010446:Peptide Fragments; D011498:Protein Precursors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; C579158:S100b protein, rat; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain