Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury.
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that ozone oxidative preconditioning (OzoneOP) attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of the OzoneOP in modulating inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to 45 min of renal ischemia, with or without treatment with OzoneOP (1 mg/kg). Renal function, inflammation and apoptosis were compared at 24 h after renal injury. OzoneOP improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, OzoneOP has potent anti-apoptotic and anti-inflammatory properties. These findings may have major implications in the treatment of human ischemic acute renal failure.
Chen
Hui
H
Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Jiefang Road 238, Wuhan, 430060, China.
Xing
Bianzhi
B
Liu
Xiuheng
X
Zhan
Bingyan
B
Zhou
Jiangqiao
J
Zhu
Hengcheng
H
Chen
Zhiyuan
Z
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D007249:Inflammation / Q000503:physiopathology / Q000517:prevention & control; D019194:Ischemic Preconditioning; D007674:Kidney Diseases / Q000503:physiopathology / Q000517:prevention & control; D007677:Kidney Function Tests; D008297:Male; D010083:Oxidants, Photochemical / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010126:Ozone / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
D010083:Oxidants, Photochemical; D010126:Ozone