Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema.
Brown
Sara J
SJ
Sandilands
Aileen
A
Zhao
Yiwei
Y
Liao
Haihui
H
Relton
Caroline L
CL
Meggitt
Simon J
SJ
Trembath
Richard C
RC
Barker
Jonathan N W N
JN
Reynolds
Nick J
NJ
Cordell
Heather J
HJ
McLean
W H Irwin
WH
D000483:Alleles; D004252:DNA Mutational Analysis; D003876:Dermatitis, Atopic / Q000235:genetics*; D000091344:Filaggrin Proteins; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D015233:Models, Statistical; D009154:Mutation; D016017:Odds Ratio; D010641:Phenotype
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins