title: Division of labor, plasticity, and crosstalk between dendritic cell subsets.
abstract: For years, dendritic cell (DC) biologists have oscillated between two seemingly antagonistic ideas: functional specialization (division of labor) of DC subsets and plasticity (multitasking). More recently, a third hypothesis is gathering support: crosstalk between functionally distinct DC subsets. This reveals a previously unappreciated hierarchy of organization within the DC system, and provides a conceptual framework to understand how cooperation between functionally distinct, yet plastic, DC subsets can shape adaptive immunity and immunological memory. Here we review the recent advances in this area.
authors: Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA. bpulend@rmy.emory.edu
authors: Bali
authors: B
authors: Pulendran
authors: Hua
authors: H
authors: Tang
authors: Timothy L
authors: TL
authors: Denning
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002450:Cell Communication; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D051379:Mice