title: Clinical significance of abnormal electrocardiographic findings in individuals aging with spinal injury and abnormal lipid profiles.
abstract: BACKGROUND
  Cardiovascular risk factors are common in individuals with chronic spinal cord injury (SCI), and their prevalence increases with age. The actual prevalence of overt cardiovascular disease (CVD) in this population has not been well established.
  
  
  METHODS
  Electrocardiograms (ECGs) were examined for abnormalities in 43 individuals with abnormal lipid profiles being followed in the outpatient SCI clinic of our institution. The mean age of the study population of predominantly men was 43 +/- 9.9 years and the mean duration of injury 16.6 +/- 8 years.
  
  
  RESULTS
  ECG abnormalities were common and present in 60.5% of participants. ST-T wave abnormalities were the most commonly observed (35%). Evidence of previous myocardial infarction was present in 7% of all individuals and in 12% of those with ECG abnormalities. The only clinical parameter differentiating the group with normal vs abnormal ECG was the duration of injury (19.5 +/- 8 y vs 12 +/- 5 y; P = 0.0026). Analysis of variance showed that injury duration was the sole predictor of abnormal ECG with 68% accuracy (P = 0.006). Among those with ECG abnormalities, although no significant differences were detected between those with and without evidence of previous myocardial infarction, mean total cholesterol and low-density lipoprotein were higher, and mean high-density lipoprotein was lower. Mean age and injury duration were greater in those with evidence of previous myocardial infarction.
  
  
  CONCLUSIONS
  Although age is an important risk factor for CVD in the population of individuals without disabilities, injury duration is at least as important as age in those with SCI. Our findings support the recommendation that individuals with SCI and abnormal lipids should be screened for CVD regardless of age.
authors: Rancho Los Amigos National Rehabilitation Center, Downey, California, USA.
authors: Yaga
authors: Y
authors: Szlachcic
authors: LeeAnne
authors: L
authors: Carrothers
authors: Rodney
authors: R
authors: Adkins
authors: Robert
authors: R
authors: Waters
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000097:blood / Q000503:physiopathology; D011782:Quadriplegia / Q000097:blood / Q000503:physiopathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000097:blood* / Q000503:physiopathology*