[Research progress on Th17 cells].
Th17(T helper 17 cell), a newly discovered subset of T cells is associated with IL-23 and characterized by production of IL-17, the functions of which are distinct from those of Th1, Th2 and Treg subsets. The development of Th17 cells can be promoted by TGF-beta1, IL-6, and IL-23; but inhibited by IFN-gamma, IL-4 and Socs3. It is clear that Th17 cells have protective effects on body by facilitating the pro-inflammatory responses. On the other hand, the role of Th17 cells in the pathophysiology of autoimmune diseases has been described.
Zhang
Wei
W
College of Medicine, Zhejiang University, Hangzhou 310058, China.
Luo
Fang-jun
FJ
Zhou
Jiao-jiao
JJ
D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000276:immunology; D053759:Interleukin-23 / Q000096:biosynthesis / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000166:cytology / Q000276:immunology*; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis / Q000235:genetics
D020381:Interleukin-17; D053759:Interleukin-23; D053773:Transforming Growth Factor beta1