Protease-resistant fraction of smoked, dried bonito alleviates atopic dermatitis-like skin lesions in NC/Nga mice.
The effect of smoke-dried bonito undigested fraction remaining after microbial protease treatment (SDBR) on a spontaneously occurring mouse model of atopic dermatitis was studied in male 5-wk-old, NC/Nga mice. Smoke-dried bonito, Katsuobushi, is a traditional Japanese food. SDBR contains 2 major components: bonito oil and protease-undigested proteins. Mice were fed a casein diet containing corn oil (C diet) or a diet containing SDBR (SDBR diet) for 18 wk. In comparison with the C diet, the SDBR diet alleviated the increase in skin severity score and plasma IgE concentration in a time-dependent manner, and lowered leucotriene B(4) (LTB(4))-releasing ability upon calcium ionophore A23187 stimulation. The SDBR diet did not affect scratching time. These results demonstrate that SDBR diet alleviates atopic dermatitis-like skin lesions in NC/Nga mice.
Matsumoto
Junichi
J
Marutomo Co. Ltd., Ehime, Japan.
Ishikawa
Shinpei
S
Doi
Mikiharu
M
Kishida
Taro
T
Ebihara
Kiyoshi
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000008:administration & dosage; D003314:Corn Oil / Q000008:administration & dosage; D003681:Dehydration; D003876:Dermatitis, Atopic / Q000178:diet therapy* / Q000517:prevention & control*; D004195:Disease Models, Animal; D005395:Fish Oils / Q000008:administration & dosage; D005399:Fishes; D005519:Food Preservation / Q000379:methods; D007073:Immunoglobulin E / Q000097:blood / Q000187:drug effects; D007975:Leukotriene B4 / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010447:Peptide Hydrolases; D012720:Severity of Illness Index; D013997:Time Factors
D002364:Caseins; D005395:Fish Oils; D007975:Leukotriene B4; D007073:Immunoglobulin E; D003314:Corn Oil; D010447:Peptide Hydrolases