title: Low bone mass in children with malignant lymphoma.
abstract: The aim of this work was to study the effect of disease process on bone mass and calcium homeo-stasis in children with malignant lymphoma at diagnosis, 3 months after starting chemotherapy, and after 1 year. Evaluation of lumber vertebrae (L2-L4) bone mineral density using dual-energy X-ray absorptiometry and calcium homeostasis parameters and bone turnover biochemical markers (serum osteocalcin and urinary deoxypyridinoline) had been assayed in twenty lymphoma patients at presentation and after treatment. Low bone mass for chronological age was observed in 4 patients (20%) at diagnosis and persisted after 3 months and 1 year. Parathyroid hormone level demonstrated no differences between children with lymphoma at different stages of therapy and controls, while 25(OH) D(3) was significantly lower in lymphoma patients at different stages of therapy as compared to controls (p < .001). Osteocalcin was significantly lower in lymphoma patients at different stages of therapy. Deoxypyridinoline showed only significant higher values after 3 months of therapy compared to controls (p = .01). In conclusion, low bone mass was observed in children with lymphoma and is related to decreased osteoblastic activity and decreased mineralization of bone.
authors: Endocrinology Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors: Magdy A
authors: MA
authors: El-Ziny
authors: Youssef A
authors: YA
authors: Al-Tonbary
authors: Osama S
authors: OS
authors: Salama
authors: Ashraf
authors: A
authors: Bakr
authors: Hala
authors: H
authors: Al-Marsafawy
authors: Ashraf A
authors: AA
authors: Elsharkawy
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000596:Amino Acids / Q000652:urine; D015519:Bone Density; D002113:Calcification, Physiologic; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006706:Homeostasis; D006801:Humans; D007223:Infant; D008159:Lumbar Vertebrae / Q000378:metabolism / Q000503:physiopathology*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000652:urine; D008297:Male; D009367:Neoplasm Staging; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D012189:Retrospective Studies
chemical_list: D000596:Amino Acids; D010281:Parathyroid Hormone; D015675:Osteocalcin; C036020:deoxypyridinoline; D002117:Calcitriol; D002118:Calcium