Synthesis and properties of pyrrolidine-based negatively charged DNA mimics.
A set of novel chiral pyrrolidine-based nucleotide mimics, in which nucleobase, hydroxyl group and phosphonic acid residue were attached to different carbon atoms of the pyrrolidine ring, was synthesized. These monomers were used for the synthesis of the corresponding oligomers, and their physico-chemical properties were evaluated.
Efimov
Vladimir A
VA
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. eva@mail.ibch.ru
Klykov
Valeryi N
VN
Chakhmakhcheva
Oksana G
OG
D004247:DNA / Q000737:chemistry*; D018716:Molecular Mimicry; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D009711:Nucleotides; D011759:Pyrrolidines; D004247:DNA; C032519:pyrrolidine