title: Leukocyte telomere length predicts cancer risk in Barrett's esophagus.
abstract: OBJECTIVE
  Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program.
  
  
  METHODS
  In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models.
  
  
  RESULTS
  Shorter telomeres were associated with increased esophageal adenocarcinoma risk (age-adjusted HR between top and bottom quartiles of telomere length, 3.45; 95% confidence interval, 1.35-8.78; P = 0.009). This association was still significant when individually or simultaneously adjusted for age, gender, nonsteroidal anti-inflammatory drug (NSAID) use, cigarette smoking, and waist-to-hip ratio (HR, 4.18; 95% confidence interval, 1.60-10.94; P = 0.004). The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio.
  
  
  CONCLUSIONS
  Leukocyte telomere length predicts risk of esophageal adenocarcinoma in patients with Barrett's esophagus independently of smoking, obesity, and NSAID use. These results show the ability of leukocyte telomere length to predict the risk of future cancer and suggest that it might also have predictive value in other cancers arising in a setting of chronic inflammation.
authors: Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA.
authors: Rosa Ana
authors: RA
authors: Risques
authors: Thomas L
authors: TL
authors: Vaughan
authors: Xiaohong
authors: X
authors: Li
authors: Robert D
authors: RD
authors: Odze
authors: Patricia L
authors: PL
authors: Blount
authors: Kamran
authors: K
authors: Ayub
authors: Jasmine L
authors: JL
authors: Gallaher
authors: Brian J
authors: BJ
authors: Reid
authors: Peter S
authors: PS
authors: Rabinovitch
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001471:Barrett Esophagus / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000473:pathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016615:Telomere / Q000378:metabolism*; D049629:Waist-Hip Ratio
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014408:Biomarkers, Tumor