title: Scoring radiologic characteristics to predict proliferative potential in meningiomas.
abstract: We investigated the feasibility of using radiologic characteristics to predict the proliferative potential in meningiomas. Our statistical analysis revealed that the presence of peritumoral edema, an ambiguous brain-tumor border, and irregular tumor shape were significantly correlated with a higher MIB-1 staining index (SI) value. We developed the following scoring system for specific features in each tumor: peritumoral edema (tumor with edema = 1, tumor without edema = 0); brain-tumor border (tumor with any ambiguous border = 1, tumor circumscribed by a distinct rim = 0); and tumor shape (tumor with irregular shape = 1, tumor with smooth shape = 0). Using Spearman's correlation coefficient analysis, we found a significant correlation (P < 0.005) between total score calculated for each patient and SI value. Our findings suggest that the proliferative potential of meningiomas can be predicted using a less invasive preoperative examination focusing on the presence of peritumoral edema, ambiguous brain-tumor border, and irregular tumor shape.
authors: Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors: Tetsuo
authors: T
authors: Hashiba
authors: Naoya
authors: N
authors: Hashimoto
authors: Motohiko
authors: M
authors: Maruno
authors: Shuichi
authors: S
authors: Izumoto
authors: Tsuyoshi
authors: T
authors: Suzuki
authors: Naoki
authors: N
authors: Kagawa
authors: Toshiki
authors: T
authors: Yoshimine
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001929:Brain Edema / Q000473:pathology; D049109:Cell Proliferation; D048430:Cell Shape / Q000502:physiology; D004396:Coloring Agents; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000473:pathology* / Q000532:radiotherapy*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000378:metabolism; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D004396:Coloring Agents; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C077171:HIVEP2 protein, human; D005682:Gadolinium