title: Evaluation of UPJ obstruction before and after pyeloplasty using MR urography.
abstract: This article builds on the previous article in this symposium and shows how MR urography contributes to the postoperative evaluation of children with UPJ obstruction. By analyzing the postoperative results, we derived new insights into their preoperative evaluation. With MR urography we combine simultaneous physiological and anatomic evaluation that enables us to identify changes in renal pathophysiology that occur in association with impaired drainage and obstruction. We studied 35 children before and after pyeloplasty. The pyeloplasty was considered successful in 30 and unsuccessful in 5. Both anatomic and functional criteria were used. The anatomic parameters included the degree of hydronephrosis, the appearance of the renal parenchyma, the quality of the nephrogram and the presence of crossing vessels. The functional criteria included the renal transit time, the calyceal transit time, the volumetric differential function, the Patlak differential function, the difference between the volumetric and Patlak differential function and the Patlak number per milliliter of renal tissue. No single parameter was sufficient to fully characterize UPJ obstruction, but by synthesizing all the information we were able to subdivide UPJ obstruction into compensated, decompensated and uropathic kidneys. Decompensated systems had the most significant improvement following successful pyeloplasty. Compensated systems showed little improvement in renal function, and uropathic kidneys were associated with a poor prognosis. It is clear that not all UPJ obstructions are the same, and it seems logical that treatment should be individually tailored rather than using a standard approach for all cases. Because MR urography can identify pathophysiological differences in children with UPJ obstruction that are occult to renal scintigraphy, it has an important potential role in identifying those who will benefit most from pyeloplasty and those who are probably best observed.
authors: Department of Radiology, Children's Healthcare of Atlanta, 1001 Johnson Ferry Road, Atlanta, GA 30342, USA.
authors: Stephen B
authors: SB
authors: Little
authors: Richard A
authors: RA
authors: Jones
authors: J Damien
authors: JD
authors: Grattan-Smith
mesh_terms: D000293:Adolescent; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D004108:Dilatation, Pathologic / Q000473:pathology / Q000503:physiopathology; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006869:Hydronephrosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D007089:Image Enhancement / Q000379:methods; D007223:Infant; D007670:Kidney Calices / Q000473:pathology / Q000503:physiopathology; D007682:Kidney Pelvis / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery
chemical_list: D003287:Contrast Media