Toward a catalytic site in DNA: polyaza crown ether as non-nucleosidic building blocks in DNA conjugates.
A number of functionalized polyaza crown ether building blocks have been incorporated into DNA-conjugates as catalytic Cu(2+) binding sites. The effect of the DNA-conjugate catalyst on the stereochemical outcome of a Cu(2+)-catalyzed Diels-Alder reaction will be presented.
Jakobsen
Ulla
U
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Rohr
Katja
K
Vogel
Stefan
S
D020134:Catalytic Domain; D003300:Copper / Q000737:chemistry*; D043844:Crown Ethers / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D013237:Stereoisomerism
D043844:Crown Ethers; D004277:DNA, Single-Stranded; D009841:Oligonucleotides; D003300:Copper