dabPNA: design, synthesis, and DNA binding studies.
In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs.
Roviello
Giovanni N
GN
Istituto di Biostutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy. giroviel@unina.it
Musumeci
Domenica
D
Moccia
Maria
M
Castiglione
Mariangela
M
Sapio
Roberto
R
Valente
Margherita
M
Bucci
Enrico M
EM
Perretta
Giuseppe
G
Pedone
Carlo
C
D020148:Butyric Acid / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D020135:Peptide Nucleic Acids; C527043:aminoethylglycyl PNA; D020148:Butyric Acid; D004247:DNA; D005998:Glycine