General aspects of the genetics of SLE.
The application of genetic techniques to the study of systemic lupus erythematosus (SLE) has identified candidate genes with diverse immunological function. There is a growing understanding that susceptibility to SLE is due to a complex interaction of multiple genes and environmental factors, and that many of these may be shared with other autoimmune diseases. In this first of a series of review articles we outline our current understanding of SLE genetics, in particular summarising the results of recent association studies.
Rhodes
B
B
Department of Molecular Genetics and Rheumatology, Imperial College, London, UK.
Vyse
T J
TJ
D000818:Animals; D004195:Disease Models, Animal; D004777:Environment; D008040:Genetic Linkage / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D051379:Mice