Thymoma-associated graft-versus-host disease-like erythroderma.
We report a 40-year-old woman with recurrent thymoma associated with myasthenia gravis, in whom an unusual form of erythroderma developed. A histological examination revealed a graft-versus-host disease (GVHD)-like reaction. After high-dose steroid therapy, the metastatic thymoma lesion in the abdominal cavity was reduced in size from 9.5 x 6 x 7.5 cm to 4 x 3 x 1 cm in diameter. Nevertheless, the GVHD-like erythroderma become aggravated, her condition worsened, and the patient finally suffered from respiratory failure and died of sepsis. A GVHD-like reaction may be a rare presentation of thymoma-associated immunological disorders such as myasthenia gravis or pure red cell aplasia. Herein, we discuss the present case and review pertinent reports of thymoma cases associated with GVHD.
Nakagiri
Tomoyuki
T
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.
Okumura
Meinoshin
M
Inoue
Masayoshi
M
Minami
Masato
M
Kiyohara
Eiji
E
Umegaki
Noriko
N
Nakamura
Toshiaki
T
Tomita
Yasuhiko
Y
Katayama
Ichirou
I
Aozasa
Katsuyuki
K
D000328:Adult; D001707:Biopsy, Needle; D003873:Dermatitis, Exfoliative / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D009157:Myasthenia Gravis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D018570:Risk Assessment; D013934:Thymectomy / Q000379:methods; D013945:Thymoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome