title: dabPNA: design, synthesis, and DNA binding studies.
abstract: In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs.
authors: Istituto di Biostutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy. giroviel@unina.it
authors: Giovanni N
authors: GN
authors: Roviello
authors: Domenica
authors: D
authors: Musumeci
authors: Maria
authors: M
authors: Moccia
authors: Mariangela
authors: M
authors: Castiglione
authors: Roberto
authors: R
authors: Sapio
authors: Margherita
authors: M
authors: Valente
authors: Enrico M
authors: EM
authors: Bucci
authors: Giuseppe
authors: G
authors: Perretta
authors: Carlo
authors: C
authors: Pedone
mesh_terms: D020148:Butyric Acid / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D020135:Peptide Nucleic Acids; C527043:aminoethylglycyl PNA; D020148:Butyric Acid; D004247:DNA; D005998:Glycine