title: Birth-related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: the ESCALE study (SFCE).
abstract: Since neuroblastoma occurs very early in children's lives, it has been hypothesized that pre- and perinatal factors may play a role in its etiology. This study investigated the role of birth characteristics, congenital malformation and maternal reproductive history in neuroblastoma. The data used were generated by the national population-based case-control study, ESCALE, conducted in France in 2003-2004. The mothers of 191 neuroblastoma cases and 1,681 controls, frequency-matched by age and gender, were interviewed by telephone, using a standardized questionnaire, on several factors including pregnancy, medical history, lifestyle, childhood medical conditions and exposures. A positive association between congenital malformation and all neuroblastoma cases was observed [Odds ratio (OR) = 2.2, 95% confidence interval (95% CI): 1.1-4.5]. Congenital malformations were highly associated to neuroblastoma in children aged less than 1 year (OR = 16.8, 95% CI: 3.1-90), while no association was observed in children aged 1 year or more (OR = 1.0, 95% CI: 0.3-2.9). A negative association with a maternal history of spontaneous abortions was also found (OR = 0.6, 95% CI: 0.4-0.9). The results strongly support the hypothesis that congenital anomalies may be associated with neuroblastoma, particularly in infant (less than 1 year of age).
authors: INSERM, U754, IFR69, Villejuif, France.
authors: Caroline
authors: C
authors: Munzer
authors: Florence
authors: F
authors: Menegaux
authors: Brigitte
authors: B
authors: Lacour
authors: Dominique
authors: D
authors: Valteau-Couanet
authors: Jean
authors: J
authors: Michon
authors: Carole
authors: C
authors: Coze
authors: Christophe
authors: C
authors: Bergeron
authors: Anne
authors: A
authors: Auvrignon
authors: Frédéric
authors: F
authors: Bernard
authors: Caroline
authors: C
authors: Thomas
authors: Jean-Pierre
authors: JP
authors: Vannier
authors: Justyna
authors: J
authors: Kanold
authors: Hervé
authors: H
authors: Rubie
authors: Denis
authors: D
authors: Hémon
authors: Jacqueline
authors: J
authors: Clavel
mesh_terms: D000293:Adolescent; D000328:Adult; D001722:Birth Order; D001724:Birth Weight; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000175:diagnosis*; D005260:Female; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007223:Infant; D008297:Male; D008423:Maternal Age; D009447:Neuroblastoma / Q000175:diagnosis*; D011247:Pregnancy; D017584:Reproductive History; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires