Serum total glutathione-s-transferase levels in oral cancer.
We conducted a study wherein serum total glutathione-s-transferase levels were measured in patients (n = 27) with various stages of biopsy proven oral cancer (squamous cell carcinoma) and age and sex matched healthy human volunteers (n=10). In all patients with oral cancer, serum total glutathione-s-transferase was measured before the onset of treatment. There was a significant increase in serum total glutathione-s-transferase levels in patients with stage IV oral cancer as compared to stage II (P = 0.001) and stage III (P = 0.002) oral cancer. This shows that alterations in serum total Glutathione-s-transferase levels may have a role in cancer progression.
Prabhu
Krishnananda
K
Department of Biochemistry, Kasturba Medical College, Manipal - 576 104, Karnataka, India. krishnakunj2000@yahoo.com
Bhat
Gopalakrishna P
GP
D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000473:pathology*; D009367:Neoplasm Staging
D005982:Glutathione Transferase