Ductal carcinoma in situ arising in a benign phyllodes tumor: report of a case.
Malignant epithelial change within a phyllodes tumor (PT) is a rare event. To our knowledge, only six cases of ductal carcinoma in situ arising in a PT have been reported in English. We report a case of PT with an intraductal carcinoma component, which grew rapidly to a huge size in 3 months. Histologically, the stromal element showed mild to moderate cellularity with few mitoses and mild nuclear atypia. The epithelial element consisted of irregularly dilated ducts with a phyllodes structure that had moderate to severe epithelial hyperplasia, and foci of cribriform ductal carcinoma in situ with comedo necrosis.
Yamaguchi
Rin
R
Kurume Daiichi Social Insurance Hospital, Kurume, Japan.
Tanaka
Maki
M
Kishimoto
Yukiya
Y
Ohkuma
Kazuaki
K
Ishida
Mayumi
M
Kojiro
Masamichi
M
D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003557:Phyllodes Tumor / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016217:Ultrasonography, Mammary