Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter.
OBJECTIVE
Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy.


METHODS
Prospective clinical trial.


METHODS
Tertiary referral center.


METHODS
One hundred thirty patients with nontoxic multinodular goiter. Patients were divided into 2 groups according to the postoperative serum calcium level. Group 1 (n = 32) consisted of patients with a postoperative serum calcium level of 8 mg/dL or less, and group 2 (n = 98) consisted of patients with a postoperative serum calcium level higher than 8 mg/dL.


METHODS
The preoperative serum 25-OHD level and preoperative and postoperative serum calcium and PTH levels were determined.


METHODS
The number of patients developing hypocalcemia and prediction of postoperative hypocalcemia by the serum 25-OHD and PTH levels.


RESULTS
Hypocalcemia developed in 32 patients (24.6%) (group 1). The preoperative serum 25-OHD level and postoperative serum calcium and PTH levels in group 1 were significantly lower than in group 2 (P = .001). With logistic regression analysis, factors that were predictive of postoperative hypocalcemia included a preoperative serum 25-OHD level less than 15 ng/mL (P < .001; odds ratio, 558.5), a postoperative serum PTH level less than 10 pg/mL (P = .01; odds ratio, 16.4), and being older than 50 years (P = .01; odds ratio, 4.6).


CONCLUSIONS
Age, a low preoperative serum 25-OHD level, and a low postoperative serum PTH level are significantly associated with postoperative hypocalcemia. The low preoperative serum 25-OHD level was more significant than the low postoperative serum PTH level in the prediction of postoperative hypocalcemia.
Erbil
Yesim
Y
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey.
Bozbora
Alp
A
Ozbey
Nese
N
Issever
Halim
H
Aral
Feríhan
F
Ozarmagan
Selçuk
S
Tezelman
Serdar
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002762:Cholecalciferol / Q000097:blood*; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000601:surgery*; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013965:Thyroidectomy / Q000009:adverse effects*
D010281:Parathyroid Hormone; D002762:Cholecalciferol