Biopsy proven acute tubular necrosis associated with vancomycin in a child: case report and literature review.
Vancomycin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. The drug does appear, however, to increase the nephrotoxicity of concurrently administered aminoglycosides. The extent of direct tubular toxicity attributable to vancomycin, especially in the absence of aminoglycoside treatment, does not appear to have been previously described. We report a case of biopsy-proven acute tubular necrosis secondary to vancomycin toxicity in a 13-year-old boy where there was no likely alternate explanation for toxic or ischemic injury. No hemodialysis was required, and the patient made a full recovery with subsequently regained renal function.
Wu
Chan-Yao
CY
Department of Pediatrics, E-DA Hospital/I-Shou University, Yan-Chau Shiang, Kaohsiung County, Taiwan.
Wang
Jyh-Seng
JS
Chiou
Yee-Hsuan
YH
Chen
Chen-Yin
CY
Su
Yu-Tsun
YT
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008181:Lupus Nephritis / Q000150:complications / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D014640:Vancomycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D014640:Vancomycin