title: Adiponectin and visfatin concentrations in children treated with valproic acid.
abstract: Chronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children. Attempts to determine the underlying pathophysiologic mechanisms have failed. Adipocytokines have recently been defined as a link between glucose and fat metabolism. We herein demonstrate that VPA-associated overweight is accompanied by lower adiponectin and higher leptin concentrations in children. The absence of any relationship with visfatin concentration does not suggest a role of this novel insulin-mimetic hormone in VPA-associated metabolic alterations. Therefore, adiponectin and leptin but not visfatin may be considered as potential regulators of glucose and fat metabolism during VPA-therapy.
authors: Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Austria. markus_rauchenzauner@hotmail.com
authors: Markus
authors: M
authors: Rauchenzauner
authors: Edda
authors: E
authors: Haberlandt
authors: Sabine
authors: S
authors: Scholl-Bürgi
authors: Barbara
authors: B
authors: Ernst
authors: Fritz
authors: F
authors: Hoppichler
authors: Daniela
authors: D
authors: Karall
authors: Christoph F
authors: CF
authors: Ebenbichler
authors: Kevin
authors: K
authors: Rostasy
authors: Gerhard
authors: G
authors: Luef
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000502:physiology*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000367:Age Factors; D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood / Q000502:physiology; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000502:physiology*; D014635:Valproic Acid / Q000009:adverse effects* / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
chemical_list: D052242:Adiponectin; D000927:Anticonvulsants; D001786:Blood Glucose; D020738:Leptin; D014635:Valproic Acid; D054409:Nicotinamide Phosphoribosyltransferase