title: Positive end-expiratory pressure in acute respiratory distress syndrome: should the 'open lung strategy' be replaced by a 'protective lung strategy'?
abstract: In patients with acute respiratory distress syndrome, positive end-expiratory pressure is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume. The best positive end-expiratory pressure should correspond to the best compromise between recruitment and distension, a condition that coincides with the best respiratory elastance.
authors: Réanimation Chirurgicale Polyvalente Pierre Viars, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris - 6, 47/83 boulevard de l'Hôpital, Paris Cédex 13, France. jjrouby.pitie@invivo.edu
authors: Jean-Jacques
authors: JJ
authors: Rouby
authors: Fabio
authors: F
authors: Ferrari
authors: Bélaïd
authors: B
authors: Bouhemad
authors: Qin
authors: Q
authors: Lu
mesh_terms: D000818:Animals; D006801:Humans; D008168:Lung / Q000502:physiology*; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology