An outbreak of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemase in western China.
Twenty-two non-repetitive carbapenem-resistant Acinetobacter baumannii isolates were obtained from Intensive Care Unit patients. All of the isolates carried bla(OXA-23), bla(OXA-66), a novel cephalosporinase-encoding gene (bla(ADC-25)) and a class 1 integron with an aacC1-orfP-orfQ-aadA1a cassette array and had identical enterobacterial repetitive intergenic consensus (ERIC) profiles. ISAba1 was found upstream of bla(OXA-23), but was not associated with bla(OXA-66) or bla(ADC-25).
Zong
Zhiyong
Z
Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Lü
Xiaoju
X
Valenzuela
Jubelle K
JK
Partridge
Sally R
SR
Iredell
Jon
J
D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D032023:Integrons; D007362:Intensive Care Units; D020071:Interspersed Repetitive Sequences; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*
D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases