title: Morphologic alterations in the corpus callosum in abuse-related posttraumatic stress disorder: a preliminary study.
abstract: Magnetic resonance imaging (MRI) studies in children with maltreatment-related posttraumatic stress disorder (PTSD) have demonstrated smaller corpus callosum area, with the greatest magnitude of change in posterior portions of the corpus callosum. The purpose of this study was to measure corpus callosum area in adult female patients with childhood abuse-related PTSD and comparison subjects. MRI was used to measure the midsagittal area of the corpus callosum as well as subregions of the corpus callosum in 9 female subjects with abuse-related PTSD and 9 healthy female subjects. No differences were found in total area of the corpus callosum or in individual subregions, but the subregion/total area ratio was significantly smaller in posterior midbody in PTSD compared with the healthy subjects. These results suggest that relatively smaller areas of the posterior midbody of the corpus callosum are associated with childhood abuse related PTSD in adults; these findings are consistent with findings in children with abuse-related PTSD.
authors: Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. norikita@fd6.so-net.ne.jp
authors: Noriyuki
authors: N
authors: Kitayama
authors: Marijn
authors: M
authors: Brummer
authors: Lois
authors: L
authors: Hertz
authors: Sinead
authors: S
authors: Quinn
authors: Yoshiharu
authors: Y
authors: Kim
authors: J Douglas
authors: JD
authors: Bremner
mesh_terms: D000328:Adult; D002648:Child; D002649:Child Abuse / Q000175:diagnosis* / Q000523:psychology; D002650:Child Abuse, Sexual / Q000175:diagnosis* / Q000523:psychology; D003337:Corpus Callosum / Q000473:pathology*; D017579:Domestic Violence / Q000523:psychology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D012016:Reference Values; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000473:pathology