title: A multicomponent synthesis of triazinane diones.
abstract: An efficient, one-pot synthetic protocol toward triazinane diones, a rather unexplored class of heterocyclic scaffolds combining phosphonates, nitriles, aldehydes, and isocyanates is described. The optimization of the reaction, synthesis of a small library of different triazinane diones, as well as alternative routes toward the triazinane dione scaffold are discussed.
authors: Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands orru@few.vu.nl.
authors: Bas
authors: B
authors: Groenendaal
authors: Danielle J
authors: DJ
authors: Vugts
authors: Rob F
authors: RF
authors: Schmitz
authors: Frans J J
authors: FJ
authors: de Kanter
authors: Eelco
authors: E
authors: Ruijter
authors: Marinus B
authors: MB
authors: Groen
authors: Romano V A
authors: RV
authors: Orru
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D003500:Cyclization; D017953:Isocyanates / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D017953:Isocyanates; D007659:Ketones; D009570:Nitriles; D063065:Organophosphonates; D054852:Small Molecule Libraries; D014227:Triazines; D014508:Urea