New developments of the "lock-in" modified cycloSal-d4TMPs.
New developments of the "lock-in" modified cycloSal-d4TMP are reported. Novel prodrugs with variations in the linker chain were introduced. The synthesis, hydrolysis properties in different media (PBS, CEM/0- and liver extracts) and the antiviral activities against HIV are shown.
Vukadinović-Tenter
Dalibor
D
Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Martin Luther King-Platz 6, 20146 Hamburg, Germany.
Balzarini
Jan
J
Meier
Chris
C
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D054306:Dideoxynucleotides / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018119:Stavudine / Q000031:analogs & derivatives* / Q000737:chemistry; D013942:Thymine Nucleotides / Q000737:chemistry*
D019380:Anti-HIV Agents; C415254:Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate; D054306:Dideoxynucleotides; D011355:Prodrugs; D013942:Thymine Nucleotides; D018119:Stavudine