Elevated levels of interleukin-2 receptor and intercellular adhesion molecule 1 in sera from a venezuelan cohort of patients with dengue.
This study evaluated the levels of soluble interleukin-2 receptor (sIL-2R) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with dengue. Sera from 17 patients with dengue fever (DF), 15 with dengue hemorrhagic fever (DHF) and 12 healthy individuals were obtained. Increased levels of sIL-2R and sICAM-1 were found in patients with DF and DHF when compared to normal; those were not correlated with leukocytes, hepatic serum enzyme levels or haemostatic parameters. Levels of sIL-2R were related to the different grades of DHF. These results suggest that increased levels of sIL-2R and sICAM-1 are a common feature of dengue.
Valero
N
N
Seccion de Virologia, Facultad de Medicina, Instituto de Investigaciones Clinicas Dr. Americo Negrette, Universidad del Zulia, Zulia, Venezuela. nere98@hotmail.com
Larreal
Y
Y
Espina
L M
LM
Reyes
I
I
Maldonado
M
M
Mosquera
J
J
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000097:blood*; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000097:blood*; D019595:Severe Dengue / Q000097:blood* / Q000276:immunology*
D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1