[The regulatory effect of mexidol on the hemoglobin level under acute stress conditions].
Experiments on a group of 39 Wistar albino male rats showed that, 2 and 5 days after a model acute stress procedure, the total amount of erythrocytes is increased. This process is accompanied by a hypochromia of red cells and by a decrease in the concentration of serum iron. Single administration of mexidol (100 mg/kg) before stress induction prevents changes in the amount of blood erythrocytes, as well as in their saturation with hemoglobin. Mexidol also prevents a decrease in the level of serum iron. The drug does not influence the hematological parameters and iron concentration in blood serum of intact animals 2 and 5 days after injection.
Deviatkina
T A
TA
Vazhnichaia
E M
EM
Oleĭnik
N A
NA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000737:chemistry / Q000473:pathology; D006454:Hemoglobins / Q000032:analysis*; D007103:Immobilization; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000209:etiology
D000975:Antioxidants; D006454:Hemoglobins; D010847:Picolines; C070020:emoxypine succinate