Synthesis of nucleosides with additional nucleobases.
The syntheses of two nucleosides with additional nucleobases in the 2'-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The nucleoside with two carbons in the linker has been incorporated into oligonucleotides and showed stabilization of a tree-way junction.
Andersen
Charlotte
C
Nucleic Acid Center, Department of Chemistry and Physics, University of Southern Denmark, DK-5230 Odense M, Denmark.
Pedersen
Søren L
SL
Nielsen
Poul
P
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009843:Oligoribonucleotides / Q000737:chemistry*
C527080:2',3',5'-tri-O-acetyl-2-amino(-N6-cyclopentyl)-1-deazaadenosine; C527079:2',3',5'-tri-O-acetyl-2-amino-1-deazaadenosine; D009705:Nucleosides; D009843:Oligoribonucleotides; D000241:Adenosine