title: Microporous polysaccharide hemospheres for management of laparoscopic trocar injury to the spleen.
abstract: BACKGROUND
  Management of iatrogenic injuries during laparoscopy can be arduous. Recent advancements in surgical hemostatic agents have provided beneficial therapeutic alternatives. This project evaluates microporous polysaccharide hemospheres (MPH), with demonstrated efficiency achieving topical hemostasis, in the setting of intracorporeal laparoscopic splenic injury.
  
  
  METHODS
  Four domestic female pigs were subjected to reproducible laparoscopic 12-mm and 5-mm trocar splenic injuries. Each surgery was an identical transperitoneal hand-assisted laparoscopic procedure. Hemostasis, or no bleeding after treatment, was achieved by measured dose applications of MPH.
  
  
  RESULTS
  The MPH successfully achieved hemostasis for all splenic injuries except in 1 case, where a 12-mm lesion transected the splenic artery. The mean time to hemostasis, applications of MPH, and estimated blood loss for the 5- and 12-mm injuries were 165.3 +/- 45.7 and 200.7 +/- 106.5 seconds, 1.3 +/- .5 applications for both, and 12.0 +/- 4.6 and 17.7 +/- 9.1 g, respectively.
  
  
  CONCLUSIONS
  MPH represents a powerful hemostatic agent that demonstrated complete hemostasis for iatrogenic splenic injury.
authors: Department of Urology, Mayo Clinic Arizona, Phoenix, AZ, USA. Humphreys.Mitchell@mayo.edu
authors: Mitchell R
authors: MR
authors: Humphreys
authors: Erik P
authors: EP
authors: Castle
authors: Paul E
authors: PE
authors: Andrews
authors: Matthew T
authors: MT
authors: Gettman
authors: Mark H
authors: MH
authors: Ereth
mesh_terms: D000007:Abdominal Injuries / Q000209:etiology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D004195:Disease Models, Animal; D005260:Female; D006488:Hemostasis, Surgical; D006490:Hemostatics; D010535:Laparoscopy / Q000009:adverse effects*; D008863:Microspheres; D011134:Polysaccharides / Q000008:administration & dosage; D013154:Spleen / Q000293:injuries* / Q000601:surgery; D013525:Surgical Instruments / Q000009:adverse effects*; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D006490:Hemostatics; D011134:Polysaccharides