Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.
Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Lee
Jeong A
JA
Moon
Hyung Ryong
HR
Kim
Hea Ok
HO
Lee
Kang Man
KM
Lee
Hyun Joo
HJ
Chun
Moon Woo
MW
D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides; D015075:2-Aminopurine; C040510:2-amino-6-chloropurine