[Neurogenesis as a therapeutic strategy to regenerate central nervous system].
BACKGROUND
In the past few years, it has been demonstrated that the adult mammalian brain maintains the capacity to generate new neurons from neural stem/progenitor cells. These new neurons integrate into pre-existing systems through a process referred to as 'neurogenesis in the adult brain'.


METHODS
This discovery has modified our understanding of how the central nervous system functions in health and disease. Until today, a great effort has been made attempting to decipher the mechanisms regulating adult neurogenesis, which might help to induce neuronal endogenous cell replacement in various neurological diseases.


CONCLUSIONS
In this revision, we will attempt to shed some light on the neurogenesis process with respect to diseases of the central nervous system and we will describe some therapeutic potentials in relation to neurodegenerative diseases.
Arias-Carrión
O
O
Experimental Neurology, Philipps University, Marburg, Alemania, México. arias@exp-neuro.de
Drucker-Colín
R
R
D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016380:Brain Tissue Transplantation; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D002493:Central Nervous System Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008322:Mammals; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D018377:Neurotransmitter Agents / Q000502:physiology
D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents