title: Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold.
abstract: The synthesis of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold is disclosed, which was synthesized using a Suzuki cross-coupling reaction and an intramolecular Heck cyclization as the key steps. This heterocyclic system can serve as a bidentate ligand as demonstrated by the formation and structural analysis of a derived ruthenium complex. The new scaffold constitutes an interesting candidate for the development of organometallic protein kinase inhibitors.
authors: Department of Chemistry, University of Pennsylvania, 231 S. 34 St., Philadelphia, PA 19104.
authors: Seann P
authors: SP
authors: Mulcahy
authors: Patrick J
authors: PJ
authors: Carroll
authors: Eric
authors: E
authors: Meggers