Effects of nicotinamide adenine dinucleotide hydride on physical and mental performance.
The aim of this study was to assess the effects of nicotinamide adenine dinucleotide hydride (NADH) on maximal oxygen uptake (VO2max), maximal anaerobic running time, and mental performance. Eight men were exposed to a supplement treatment (30 mg NADH as ENACHI tablets per day) and to a placebo treatment, each of 4 weeks' duration, in a balanced, double-blind, and cross-over design. The two treatments were separated by a 14-week wash-out period. The results indicated that VO2max, maximal anaerobic running time, and the ability to concentrate were similar in the NADH and placebo conditions. There were also no differences in blood lactate, creatine kinase, reaction time or feelings of fatigue between the treatments. A counter-movement jump performed at rest and 2 min after the aerobic test differed significantly (P <or= 0.05) between the treatment conditions and was higher in the NADH group. In conclusion, the NADH supplementation for 4 weeks had no effects on VO2max, maximal anaerobic running time or mental performance.
Mero
Antti
A
Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland. antti.mero@sport.jyu.fi
Raitanen
Riikka
R
Birkmayer
Joerg
J
Komi
Paavo
P
D001317:Austria; D003071:Cognition / Q000187:drug effects*; D003402:Creatine Kinase / Q000032:analysis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D009243:NAD / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010919:Placebos
D010919:Placebos; D009243:NAD; D019344:Lactic Acid; D003402:Creatine Kinase