Efficient synthesis of benzamide riboside, a potential anticancer agent.
An efficient five step synthesis of benzamide riboside (BR) amenable for a large scale synthesis has been developed. It allows for extensive pre-clinical studies of BR as a potential anticancer agent.
Bonnac
Laurent F
LF
Center for Drug Design, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA.
Gao
Guang-Yao
GY
Chen
Liqiang
L
Patterson
Steven E
SE
Jayaram
Hiremagalur N
HN
Pankiewicz
Krzysztof W
KW
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000737:chemistry; D009705:Nucleosides / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009705:Nucleosides; C076145:3-(1-deoxyribofuranosyl)benzamide; D007168:IMP Dehydrogenase; D009612:Nicotinamide-Nucleotide Adenylyltransferase