Does dipyridamole-induced ischaemia affect NT-proBNP secretion?
BACKGROUND
B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NTproBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by improving the sensitivity of exercise- stress testing.


OBJECTIVE
To observe the relationship between dipyridamole- induced ischaemia and the secretion of NT-proBNP.


METHODS
A total of 52 consecutive patients, referred for dipyridamole stress 99m Tc-sestamibi single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) to diagnose reversible ischaemia, were enrolled. NT-proBNP was determined at rest and one hour after infusion of dipyridamole.


RESULTS
Of the 52 patients, 25 had normal scans, 12 had scans with fixed defects (previous myocardial infarction with no inducible ischaemia) and 15 had reversible perfusion defects (inducible ischaemia). There was no correlation between ischaemia and resting NT-proBNP, post-stress NT-proBNP and the change in NT-proBNP. There was a correlation between ejection fraction, ventricular volumes and resting NT-proBNP.


CONCLUSIONS
NT-proBNP does not add to the diagnosis of myocardial ischaemia in dipyridamole stress MPI.
De Greef
Jacques
J
Department of Chemical Pathology, University of Pretoria, Pretoria.
Govender
Radha
R
Vermaak
William
W
Perumal
Nalini
N
Libhaber
Elena
E
Vangu
Mboyo-Di-Tamba
MD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004176:Dipyridamole; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
D015415:Biomarkers; D010446:Peptide Fragments; D014665:Vasodilator Agents; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi