Antioxidant and antiatherogenic activity of cis-Hinokiresinol from Trapa pseudoincisa.
cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The ICso values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 microM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 microM, respectively.
Song
Myoung-Chong
MC
Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 446-701, Korea.
Yang
Hye-Joung
HJ
Bang
Myun-Ho
MH
Kim
Dae-Keun
DK
Jeong
Tae-Sook
TS
Kim
Jong-Pyung
JP
Baek
Nam-In
NI
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D029561:Lythraceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D064801:Phospholipase A2 Inhibitors
D000975:Antioxidants; D017705:Lignans; D008077:Lipoproteins, LDL; D010636:Phenols; D064801:Phospholipase A2 Inhibitors; C119821:hinokiresinol