title: Synthesis and characterization of novel biodegradable poly(carbonate ester)s with photolabile protecting groups.
abstract: Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-MCC)) was obtained by UV irradiation of poly(L-lactide acid-co-5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one) (P(LA-co-MNC)) to remove the protective 2-nitrobenzyl group. The free carboxyl groups on the copolymers P(LA-co-MCC) were reacted with paclitaxel, a common antitumor drug. Gel permeation chromatography and NMR studies confirmed the copolymer structures and successful attachment of paclitaxel to the copolymer.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, People's Republic of China,.
authors: Zhigang
authors: Z
authors: Xie
authors: Xiuli
authors: X
authors: Hu
authors: Xuesi
authors: X
authors: Chen
authors: Jing
authors: J
authors: Sun
authors: Quan
authors: Q
authors: Shi
authors: Xiabin
authors: X
authors: Jing
mesh_terms: D002254:Carbonates / Q000138:chemical synthesis*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry
chemical_list: D002254:Carbonates; D004952:Esters