title: [Periodic motor-secretory activity of the stomach in disbalance of its regulatory mechanisms].
abstract: The periodic gastric motor-and-secretor activity in modeling of disbalance of autonomic nervous regulation in chronic fistula canine experiments was studied. It was found that autonomic nervous disbalance at the first stages was accompanied with reorganization of periodic gastric motor and secretor phase lengths which resulted in shortening of gastric basic myoelectrical rhythm period (BMRP), appearing of gastric acid secretion in fasted state and increasing of secretor response to exogenous histamine stimulation. Indeed, the gastric motor rhythms appeared to be more sensitive to changes in activity of regulatory mechanisms than the functional activity of the gastric secretor glands. Long-term disbalance of regulatory mechanisms caused the "regulatory rejection", which was associated with increasing of duodenogastric reflux and increasing of gastric BMRP, as well as with decreasing of gastric mucosal defending properties. We hypothesize that nonadrenergic noncholinergic pathway may play a role in reorganization of the observed gastric motor-and-secretor activity.
authors: O S
authors: OS
authors: Trushenko
authors: O B
authors: OB
authors: Murzin
authors: A I
authors: AI
authors: Rudenko
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000187:drug effects / Q000502:physiology*; D013270:Stomach / Q000187:drug effects / Q000294:innervation / Q000502:physiology*
chemical_list: D006632:Histamine; D002217:Carbachol