[Screening for dyslipidemia based on family history combined with obesity in children].
OBJECTIVE
To explore the significance of family history combined with obesity in screening dyslipidemia in children.


METHODS
Cluster-randomized samplings in a transecting epidemiological survey for children aged 6 to 18 years in Beijing area were used. A total of 9,495 boys and 9,542 girls were virtually included in the study. They were divided into four groups as school boys, adolescent boys, school girls and adolescent girls. Their fasting capillary blood total cholesterol (TC) levels, triglyceride (TG) levels, body height and body weight were detected.


RESULTS
Of the detected children, 38% were with family history, 4.9% obese, 2.5% both obese and positive family history and 40.4% with positive family history or obese. The percentages of dyslipidemia in non-obese children without family history, non-obese children with family history, obese children without family history, and obese children with family history were as follows: hyperlipidemia: 7.9%, 9.6%, 30.1% and 31.5%, respectively; hypercholesterolemia: 0.9%, 1.5%, 3.3% and 2.9%, respectively; hypertriglyceridemia: 7.1%, 8.6%, 29.2% and 31.3% respectively. Odds Ratios (95%CI) of dyslipidemia in obese children including school boys, adolescent boys, school girls and adolescent girls were 6.439(4.178-9.925),6.287 (4.153-9.518),5.063 (3.041-8.427) and 3.665 (2.536-5.296),respectively. Odds Ratios (95%CI) of dyslipidemia in children with family history including school boys, adolescent boys, school girls and adolescent girls were 1.204 (0.952-1.522) (P=0.121),1.331 (1.047-1.692) (P=0.020),1.095 (0.847-1.416) (P=0.490) and 1.260 (1.070-1.483) (P=0.005), respectively. In children with dyslipidemia, 43.8% were with positive family history, 15.8% obese, 8.2% both obese and positive family history, and 51.3% either obese or positive family history.


CONCLUSIONS
Family history combined with obesity is important in identifying dyslipidemia in children.
Yan
Hui
H
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Mi
Jie
J
Liu
Ying
Y
D000293:Adolescent; D001835:Body Weight; D002648:Child; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D016017:Odds Ratio; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol