A doubleheader in endocytosis.
Synaptojanin1 degrades the signaling lipid phosphatidylinositol-4,5-bisphosphate and facilitates compensatory endocytosis, clathrin-coat disassembly, and vesicle reavailability at active synapses. In this issue of Neuron, Mani et al. provide new information about the separate roles of synaptojanin's two phosphatase domains and its interactions with endophilin in regulating these important aspects of the vesicle cycle.
Zanazzi
George
G
Graduate Program in Neuroscience, State University of New York, Stony Brook, NY 11794-5230, USA.
Matthews
Gary
G
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism* / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology
D002966:Clathrin; D009419:Nerve Tissue Proteins; D000217:Acyltransferases; C018764:2-acylglycerophosphate acyltransferase; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases