Penile malignant peripheral nerve sheath tumour (schwannoma) in a three-year-old child without evidence of neurofibromatosis.
Malignant schwannoma (malignant peripheral nerve sheath tumour, MPNST) is a rare high-grade tumour arising from peripheral nerves. We report the case of a 3-year-old male who presented with a non-tender lesion on the dorsum of his penis. The lesion was excised and a formal circumcision performed. Histology of the lesion revealed a spindle cell tumour. Immunohistochemistry showed the tumour cells to be strongly positive for S100 and Vimentin. A diagnosis of intermediate grade malignant peripheral nerve sheath tumour was made. Malignant schwannoma is rare in children and is previously unreported in the penis in the paediatric age group without evidence of neurofibromatosis.
Mortell
A
A
Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
Amjad
B
B
Breatnach
F
F
Devaney
D
D
Puri
P
P
D014408:Biomarkers, Tumor / Q000378:metabolism; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009442:Neurilemmoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D017253:Neurofibromatoses / Q000175:diagnosis*; D010412:Penile Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D013521:Urologic Surgical Procedures, Male / Q000379:methods
D014408:Biomarkers, Tumor; D009418:S100 Proteins