CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry.
The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure. The program is freely available at http://www.pu.kielce.pl/ibiol/cabas.
Deperas
Joanna
J
Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warszawa, Poland.
Szluinska
Marta
M
Deperas-Kaminska
Marta
M
Edwards
Alan
A
Lloyd
David
D
Lindholm
Carita
C
Romm
Horst
H
Roy
Laurence
L
Moss
Raymond
R
Morand
Josselin
J
Wojcik
Andrzej
A
D000465:Algorithms; D001681:Biological Assay / Q000295:instrumentation / Q000379:methods / Q000592:standards; D002869:Chromosome Aberrations / Q000187:drug effects*; D020732:Cytogenetic Analysis / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D005060:Europe; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software