[Chronic blockade of serotonin transporter promotes restoration of the sensitivity of pulmonary vessels to vasoconstrictive agents in rats with monocrotaline-induced pulmonary hypertension].
Dose-dependent change of the reactivity of pulmonary vessels with respect to serotonin and phenylephrine were investigated in rats with monocrotaline-induced pulmonary hypertension caused by the chronic administration of fluoxetine. It was found that the treatment with fluoxetine favors a decrease of the vasoconstrictive response in pulmonary vessels. The results suggest that the chronic administration of fluoxetine can restore the reactivity of pulmonary vessels and eliminate the symptoms of pulmonary hypertension.
Kozhevnikova
V V
VV
Medvedeva
N A
NA
D000818:Animals; D005473:Fluoxetine / Q000494:pharmacology; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D016686:Monocrotaline / Q000633:toxicity; D010656:Phenylephrine / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D005473:Fluoxetine; D016686:Monocrotaline; D010656:Phenylephrine; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D014662:Vasoconstrictor Agents