Drug induced intracranial hypertension associated with sulphasalazine treatment.
A 25-year-old female patient developed headache and papilledema under sulphasalazine treatment for ulcerative colitis. The patient met the International Headache Society's criteria for idiopathic intracranial hypertension. Sulphasalazine was discontinued and the patient was given azathioprine for ulcerative colitis and acetazolamide for intracranial hypertension. Three weeks later, her examination was normal and lumbar puncture revealed an opening pressure of 180-mm H(2)O. Sulphasalazine is a product of 5 aminosalicylate (5 ASA) and there seems to be a relationship between the administration of sulphasalazine and the onset of intracranial hypertension symptoms. Early diagnosis of intracranial hypertension is important in patients with ulcerative colitis receiving 5 ASA treatment to prevent visual complications.
Sevgi
Eser
E
Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
Yalcin
Gul
G
Kansu
Tulay
T
Varli
Kubilay
K
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D019586:Intracranial Hypertension / Q000139:chemically induced* / Q000175:diagnosis; D012460:Sulfasalazine / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine