[Chronic administration of serotonin transporter inhibitor (fluoxetine) decreases monocrotaline-induced pulmonary hypertension in rats].
The effect of a chronic fluoxetine treatment on the development of monocrotaline-induced pulmonary hypertension has been studied in rats. It was found that fluoxetine decreased right ventricular hypertrophy and reduces pulmonary vessels thickness. These results suggest that chronic fluoxetine treatment can lead to a decrease in the manifestation of pulmonary hypertension symptoms.
Kozhevnikova
V V
VV
Medvedeva
N A
NA
D000818:Animals; D005473:Fluoxetine / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D016686:Monocrotaline; D009206:Myocardium / Q000473:pathology; D011651:Pulmonary Artery / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D005473:Fluoxetine; D016686:Monocrotaline; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors