[Hepatoprotective effect of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol].
2-Demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol (11-DMP) produces antioxidant effect on the models of toxic hepatitis induced by paracetamol and carbon tetrachloride. The drug normalizes the lipid peroxidation (LPO) prosess in rat liver of the rat and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the rat blood, thus demonstrating hepatoprotective action.
Sapozhnikova
T A
TA
Zarudiĭ
F S
FS
Baschenko
N Zh
NZh
Makara
N S
NS
Khisamutdinova
R Iu
RIu
Gabdrakhmanova
S F
SF
Ivanova
N A
NA
Nazarov
V S
VS
D000082:Acetaminophen / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D000975:Antioxidants; D020011:Protective Agents; D016595:Misoprostol; D000082:Acetaminophen; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase