title: International study on Sagliker syndrome and uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic kidney disease patients.
abstract: OBJECTIVE
  It is known that skeletal changes due to secondary hyperparathyroidism (SH) can be severe in chronic kidney disease (CKD). Recently described Sagliker syndrome (SS) is a very striking and prominent feature of SH in CKD, including an uglifying appearance to the face, short stature, extremely severe maxillary and mandibulary changes, soft tissue in the mouth, teeth/dental abnormalities, fingertip changes, knee and scapula deformities, hearing abnormalities, and neurological and, more important, severe psychological problems.
  
  
  METHODS
  In the past 8 years, we have encountered 40 cases of SS in SH and CKD by performing an international study in Turkey, India, Romania, Egypt, Maleysia, Tunis, and China.
  
  
  RESULTS
  The medical history of these patients showed that they did not receive proper therapy. Changes, particularly in children and teenagers, become irreversible, which was disastrous for the patients both aesthetically and psychologically.
  
  
  CONCLUSIONS
  Treatment must begin early and be the appropriate treatment given in centers with sophisticated skills. Otherwise, the inability to correct all the changes in the skull and face, to remodel a new face, to extending the height, and, most important, to convince the patients to face the dramatic psychological problems can be catastrophic for those patients.
authors: Nephrology Division, Cukurova University, Adana, Turkey. ysagliker@yahoo.com
authors: Yahya
authors: Y
authors: Sagliker
authors: Vidya
authors: V
authors: Acharya
authors: Zhang
authors: Z
authors: Ling
authors: Ovidia
authors: O
authors: Golea
authors: Alaa
authors: A
authors: Sabry
authors: Kamil
authors: K
authors: Eyupoglu
authors: Dhananjay S
authors: DS
authors: Ookalkar
authors: Shruti
authors: S
authors: Tapiawala
authors: Santosh
authors: S
authors: Durugkar
authors: Prakash
authors: P
authors: Khetan
authors: Cristina
authors: C
authors: Capusa
authors: Ramazan
authors: R
authors: Univar
authors: Ismail
authors: I
authors: Yildiz
authors: Kuddisi
authors: K
authors: Cengiz
authors: Musa
authors: M
authors: Bali
authors: Piril Sagliker
authors: PS
authors: Ozkaynak
authors: Hasan Sabit
authors: HS
authors: Sagliker
authors: Nuray
authors: N
authors: Paylar
authors: Siddik Momin
authors: SM
authors: Adam
authors: Mustafa
authors: M
authors: Balal
authors: Saime
authors: S
authors: Paydas
authors: Osman
authors: O
authors: Demirhan
authors: Deniz
authors: D
authors: Tasdemir
authors: Hedi
authors: H
authors: Ben Maiz
authors: Dana
authors: D
authors: Redulescu
authors: Liliana
authors: L
authors: Garneata
authors: Gabriel
authors: G
authors: Mircescu
authors: Rui
authors: R
authors: Hong-Liang
authors: Lide
authors: L
authors: Lun
authors: Kasim
authors: K
authors: Yildizer
authors: Idris
authors: I
authors: Emir
authors: Musa
authors: M
authors: Yuksekgonul
authors: Yavuz
authors: Y
authors: Yenicerioglu
authors: Harun
authors: H
authors: Akar
authors: Cemal
authors: C
authors: Sagliker
authors: Mustafa
authors: M
authors: Esenturk
authors: Necati
authors: N
authors: Kiralp
mesh_terms: D000328:Adult; D001827:Body Height; D005145:Face / Q000002:abnormalities*; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology / Q000523:psychology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D035781:Siblings; D012886:Skull / Q000033:anatomy & histology; D013131:Spine / Q000002:abnormalities