[Molecular mechanism of oncogenesis and progression in human myeloma].
Cellular biology of primary myeloma cells from myeloma patients, has been rapidly developing by using DNA analysis, gene expression profiling (GEP) and surface marker analysis. These studies reveal that human myeloma cells specifically lose the expression of B cell master gene, PAX-5, and express multi-lineage markers, and XBP-1 transgenic mice showed the late onset of human myeloma-like monoclonal plasmacytosis in the bone marrow of aged mice. GEP reveals that primary myeloma cells are subdivided into 7 groups: among these subgroups, PR (proliferation) group predicts poor prognosis. With regard to molecular mechanism of myeloma oncogenesis, the importance of primary IgH translocation followed by the second IgH translocation is proposed, but it is also noted that human myeloma cells show the marked heterogeneity.
Kawano
Michio M
MM
Laboratory of Cellular Signal Analysis, Graduate School of Medicine, Yamaguchi University.
Otsuyama
Ken-ichiro
K
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D018450:Disease Progression; D020869:Gene Expression Profiling; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology*; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; D010950:Plasma Cells / Q000166:cytology / Q000473:pathology; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D014178:Translocation, Genetic; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human; C000605544:Xbp1 protein, mouse