title: 5-HT(1B) receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running.
abstract: BACKGROUND
  Serotonin 5-HT(1B) receptors are promising targets for the management of several mood and impulse disorders.
  
  
  OBJECTIVE
  These experiments examine a 5-HT(1B) agonist, CP-94,253, and attempt to distinguish between its effects on seeking to perform three rewarding behaviors: aggression, drinking, and wheel running.
  
  
  METHODS
  Male CFW mice perform nose-poke responses that are maintained by a fixed interval schedules of 10-min (FI10) schedule to gain access to one of three rewarding activities. The first experiment studies mice reinforced by the opportunity to confront an intruder mouse after drinking water or alcohol; the second studies mice reinforced by the presentation of alcoholic or non-alcoholic solutions (i.e., 6% ethanol, 0.05% saccharin vs 0.05% saccharin); the third studies mice reinforced by access to a running wheel.
  
  
  RESULTS
  CP-94,253 (1.0-10 mg/kg i.p.) dose-dependently reduces aggression, drinking, and wheel running. Of these behaviors, alcohol-heightened aggression is the most sensitive to the 5-HT(1B) receptor agonist (ED50 = 4.8 mg/kg). Responding for the opportunity to drink or engage in alcohol-heightened aggression is suppressed by the highest dose of CP-94,253, whereas CP-94,253 does not affect responding that is reinforced by wheel running or species-typical aggression.
  
  
  CONCLUSIONS
  These results confirm the inhibitory effects of 5-HT(1B) receptor stimulation on aggressive performance and drinking. They also reveal an inhibition of voluntary wheel running, contrary to the stimulation of running in a novel, open arena. 5-HT(1B) receptor agonists may be particularly useful for the treatment of aggressive behavioral disorders, but their efficacy and potency appear to be sensitive to the intensity and context of the behavior.
authors: Department of Psychology, Tufts University, 530 Boston Ave. (Bacon Hall), Medford, MA, USA.
authors: Eric W
authors: EW
authors: Fish
authors: Sara D
authors: SD
authors: McKenzie-Quirk
authors: Makoto
authors: M
authors: Bannai
authors: Klaus A
authors: KA
authors: Miczek
mesh_terms: D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000378:Agonistic Behavior / Q000187:drug effects / Q000502:physiology; D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects* / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology*; D044302:Receptor, Serotonin, 5-HT1B / Q000502:physiology; D058825:Serotonin 5-HT1 Receptor Agonists
chemical_list: C097067:CP 94253; D011725:Pyridines; D044302:Receptor, Serotonin, 5-HT1B; D058825:Serotonin 5-HT1 Receptor Agonists; D000431:Ethanol