Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.
Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.
Kontoyiannis
Dimitrios P
DP
M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030-3930, USA. dkontoyi@mdanderson.org
Lewis
Russell E
RE
Alexander
Barbara D
BD
Lortholary
Olivier
O
Dromer
Françoise
F
Gupta
Krishan L
KL
John
George T
GT
Del Busto
Ramon
R
Klintmalm
Goran B
GB
Somani
Jyoti
J
Lyon
G Marshall
GM
Pursell
Kenneth
K
Stosor
Valentina
V
Munoz
Patricia
P
Limaye
Ajit P
AP
Kalil
Andre C
AC
Pruett
Timothy L
TL
Garcia-Diaz
Julia
J
Humar
Atul
A
Houston
Sally
S
House
Andrew A
AA
Wray
Dannah
D
Orloff
Susan
S
Dowdy
Lorraine A
LA
Fisher
Robert A
RA
Heitman
Joseph
J
Albert
Nathaniel D
ND
Wagener
Marilyn M
MM
Singh
Nina
N
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D065095:Calcineurin Inhibitors; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D016377:Organ Transplantation / Q000009:adverse effects*; D016559:Tacrolimus / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
D000935:Antifungal Agents; D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus