title: Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention.
abstract: A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.
authors: Second Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, Japan. matsuoyo@takii.kmu.ac.jp
authors: Yoichiro
authors: Y
authors: Matsuoka
authors: Tetsuya
authors: T
authors: Hamaguchi
authors: Katsumi
authors: K
authors: Fukamachi
authors: Midori
authors: M
authors: Yoshida
authors: Gen
authors: G
authors: Watanabe
authors: Kazuyoshi
authors: K
authors: Taya
authors: Hiroyuki
authors: H
authors: Tsuda
authors: Airo
authors: A
authors: Tsubura
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D011905:Genes, ras; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000473:pathology* / Q000517:prevention & control*; D011230:Precancerous Conditions / Q000473:pathology; D000090063:Proto-Oncogene Mas; D051381:Rats