title: Relationship between mandibular inferior cortex and general bone metabolism in older adults.
abstract: The purpose of this study was to investigate whether a link exists between the jawbone and general bone metabolism. The results of our study indicate that a mandibular inferior cortical erosion finding on dental panoramic radiographs is significantly associated with increased biochemical markers of bone turnover.
  
  
  BACKGROUND
  The purpose of this study was to investigate whether a link exists between the jawbone and general bone metabolism.
  
  
  METHODS
  We measured values of serum bone-specific alkaline phosphatase (S-BAP) and urinary N-telopeptide cross-links of type I collagen (U-NTX). To evaluate the jawbone, we used mandibular inferior cortex (MIC) classification on dental panoramic radiographs. After 134 subjects were divided into three groups (C1: normal cortex, C2: mildly to moderately eroded cortex, C3: severely eroded cortex), we evaluated the relationship between S-BAP or U-NTX and MIC classification by Scheffe's multiple comparison test.
  
  
  RESULTS
  A significant correlation was found between MIC classification and S-BAP (C1 vs. C2: p < 0.01, C1 vs. C3: p < 0.01, C2 vs. C3: NS). A significant correlation was found between MIC classification and U-NTX (C1 vs. C2: p < 0.01, C1 vs. C3: p < 0.001, C2 vs. C3: p < 0.01).
  
  
  CONCLUSIONS
  The results of our study indicate that the mandibular inferior cortical erosion finding on dental panoramic radiographs is significantly associated with increased S-BAP and U-NTX levels. We suggest that there is an association between the jawbone and general bone metabolism.
authors: Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho-Dori, Chuo-Ku, Niigata, 951-8514, Japan. tomoya-d@dent.niigata-u.ac.jp
authors: T
authors: T
authors: Deguchi
authors: A
authors: A
authors: Yoshihara
authors: N
authors: N
authors: Hanada
authors: H
authors: H
authors: Miyazaki
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging* / Q000378:metabolism; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000378:metabolism; D010455:Peptides / Q000652:urine*; D011862:Radiography, Panoramic
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase