title: Elevated plasma leptin levels associated with high blood pressure and TG rich lipoproteins but not associated with plasma gonadotropins, estradiol and cortisol levels in peri- and postmenopausal lean women with undefined symptoms.
abstract: We evaluated associations of leptin with blood pressure, plasma lipid metabolism, and endocrine status in 140 perimenopausal Japanese women. In this study, the mean plasma leptin level is 8.6 +/- 4.8 ng/ml and the range is 1.7 to 29.6 ng/ml. There were significant correlations between plasma leptin concentration and systolic blood pressure (r +/- 0.647, p < 0.0001) and diastolic blood pressure (r = 0.242, p = 0.0043). We observed significant correlation of plasma leptin concentration and LDL-cholesterol, triglyceride concentrations. However, no significant differences were observed in the correlation of plasma leptin and LH, FSH, estradiol and cortisol concentrations. In conclusion, leptin showed a significant association with blood pressure and lipid metabolism. It is suggested that leptin may play an important role in physiological regulation of sympathetic nervous system and lipid metabolism in peri-and postmenopausal women.
authors: Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp
authors: T
authors: T
authors: Ushiroyama
authors: A
authors: A
authors: Ikeda
authors: S
authors: S
authors: Higashio
authors: K
authors: K
authors: Sakuma
authors: M
authors: M
authors: Ueki
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D047648:Perimenopause / Q000097:blood; D017698:Postmenopause / Q000097:blood; D014280:Triglycerides / Q000097:blood*
chemical_list: D006065:Gonadotropins, Pituitary; D020738:Leptin; D008074:Lipoproteins; D014280:Triglycerides; D004958:Estradiol; D006854:Hydrocortisone