Comparison of 1H-MRS-detected metabolic characteristics in single metastatic brain tumors of different origin.
Various types of intracranial metastases exhibit different growth patterns, which can be reflected in their metabolic characteristics and investigated noninvasively by proton magnetic resonance spectroscopy (1H-MRS). The objective of the present study was comparison of the 1H-MRS-detected metabolic parameters in brain metastases of different origin. Twenty-five patients (15 men and 10 women; mean age, 62.0 years) with single, previously nontreated metastatic brain tumors were investigated by long-echo single-voxel volume-selected 1H-MRS. The primary cancer was located in the lungs (10 cases), colon and rectum (8 cases), breast (3 cases), kidney (2 cases), prostate (1 case), and cardiac muscle (1 case). Comparison of clinical and radiological variables, including type of tumor contrast enhancement and extension of peritumoral edema, did not disclose statistically significant differences in metastatic brain tumors of different origin. At the same time, comparison of 1H-MRS-detected metabolic characteristics revealed that metastases of colorectal carcinoma have greater content of mobile lipids (Lip) compared to other neoplasms. In conclusion, high Lip content in the viable brain metastases of colorectal carcinoma can be used as an additional diagnostic clue for noninvasive identification of these tumors and should be taken into consideration in cases of 1H-MRS-based differentiation of their recurrence and radiation-induced necrosis after radiosurgical or radiotherapeutic treatment.
Chernov
Mikhail F
MF
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, 162-8666, Japan. m_chernov@yahoo.com
Ono
Yuko
Y
Kubo
Osami
O
Hori
Tomokatsu
T
D000368:Aged; D001923:Brain Chemistry / Q000502:physiology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D007294:Inositol / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015173:Supratentorial Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary
D007294:Inositol