Serotonergic drugs--a possible role in the treatment of psoriasis?
Psoriasis is a chronic inflammatory skin disease, where specific immunity and/or innate immunity may be of importance in the disease pathogenesis. Psoriasis may be worsened by stress, which suggests that a neuroimmune interaction is contributing to the disease. Serotonin (5-HT) is a monoamine which besides general effects also has an impact on cell proliferation, migration and apoptosis. 5-HT exerts its effects via several receptors. 5-HT has a role in inflammation, and 5-HT receptors as well as its transporter protein have been found in psoriatic skin. 5-HT 1A receptor-positive mast cells, and 5-HT 2A receptor and serotonin reuptake transporter (SERT)-positive T lymphocytes may be targets for therapy with serotonergic drugs in psoriasis.
Thorslund
Kristofer
K
Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden. kristofer.thorslund@karolinska.se
Nordlind
Klas
K
D000818:Animals; D006801:Humans; D008954:Models, Biological; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000502:physiology; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use*
D011985:Receptors, Serotonin; D018490:Serotonin Agents; D012701:Serotonin