Intravascular B-cell lymphoma with leukemic presentation: case report and literature review.
Intravascular lymphoma is an extremely rare, disseminated, and aggressive extranodal CD20+ non-Hodgkin's lymphoma characterized by the presence of lymphoma cells only in the lumina of small vessels. We report a 72-year-old woman with a diagnosis of intravascular lymphoma presented with splenomegaly and leukemic appearance in the peripheral blood smear. Her clinical course was rapidly deteriorated before the initiation of specific chemotherapy and finally died due to multiorgan insufficiency. Bone marrow biopsy revealed a characteristic infiltration of CD5, CD10 B-cell lymphoma. To our knowledge, this is the first reported case of a CD5, CD10 intravascular B-cell lymphoma with leukemic presentation in peripheral blood with multiple cytogenetic aberrations.
Xanthopoulos
Vasilios
V
Department of Clinical Hematology, G. Gennimatas Hospital, Athens, Greece.
Galanopoulos
Athanasios G
AG
Paterakis
Georgios
G
Apessou
Dimitra
D
Argyrakos
Theodoros
T
Goumakou
Eleni
E
Papadhimitriou
Stephanos I
SI
Savvidou
Ioanna
I
Georgiakaki
Maria
M
Anagnostopoulos
Nikolaos I
NI
D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis; D018952:Antigens, CD34 / Q000096:biosynthesis; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D018956:CD5 Antigens / Q000096:biosynthesis; D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007938:Leukemia / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications*; D015260:Neprilysin / Q000096:biosynthesis; D013163:Splenomegaly / Q000188:drug therapy
D018951:Antigens, CD20; D018952:Antigens, CD34; D018956:CD5 Antigens; D015260:Neprilysin