Human papillomavirus in cervical and head-and-neck cancer.
Cervical cancer is a major cause of cancer mortality in women worldwide and is initiated by infection with high-risk human papillomaviruses (HPVs). High-risk HPVs, especially HPV-16, are associated with other anogenital cancers and a subgroup of head-and-neck cancers. Indeed, HPV infection could account for the development of head-and-neck cancer in certain individuals that lack the classical risk factors for this disease (tobacco and alcohol abuse). This Review summarizes the main events of the HPV life cycle, the functions of the viral proteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms and disease outcomes in head-and-neck cancer. The demonstration that HPVs have a role in human carcinogenesis has allowed the development of preventive and therapeutic strategies aimed at reducing the incidence and mortality of HPV-associated cancers.
Psyrri
Amanda
A
Department of Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8020, USA. diamando.psyrri@yale.edu
DiMaio
Daniel
D
D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control / Q000821:virology*; D005260:Female; D016147:Genes, Tumor Suppressor; D006258:Head and Neck Neoplasms / Q000517:prevention & control / Q000821:virology*; D006801:Humans; D016233:Immunotherapy, Active / Q000706:statistics & numerical data; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009857:Oncogenes; D030361:Papillomavirus Infections / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D002578:Uterine Cervical Dysplasia / Q000821:virology / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology
D053918:Papillomavirus Vaccines; D014764:Viral Proteins