title: Interstitial and glomerular renal involvement in sarcoidosis.
abstract: Sarcoidosis is a systemic disease characterized by chronic granulomatous inflammation. Chronic kidney disease (CKD) was reported in less than 1% of patients of sarcoidosis. The prevalence of tubulo-interstitial nephritis (TIN) in sarcoidosis varies from 7 to 27%. In this retrospective study, we present 15 patients with interstitial or glomerular renal involvement secondary to sarcoidosis diagnosed in our center from 1975 to 2006. Patients were 13 (96.6%) females and two males with a mean age of 56.5 years. CKD was present in 14(93.3%) patients, proteinuria in 13(96.6%), and nephrotic syndrome in one. Pulmonary involvement was present in 10 (66.6%) patients. Renal biopsy performed in 12 (80%) patients revealed TIN lesions in 10 (66.6%) patients, extracapillary proliferative glomerulonephritis (GN) in one, and membranous GN type 2 in another. Corticosteroid therapy using prednisolone 0.5 to 1 mg/kg per day was used in 12(80%) patients. Ten (66.6%) patients were followed up for a mean period of 25 months (ranged from 2 to 48 months). The outcome was favorable with 7 (46.6%) patients improved their renal function, 6 (40%) remained with a moderate CKD, one normalized his renal function, and one died suddenly after 2 months of initiating the treatment corticosteroids. We conclude that corticosteroid treatment is efficient in TIN and variably efficient in GN. Patients with sarcoidosis may cause advanced renal failure, which renders it a serious nephrological condition.
authors: Department of Internal Medicine and Nephrology, Charles Nicolle Hospital, Tunis, Tunisia. hayet.kaarout@rns.tn
authors: Hayet
authors: H
authors: Kaaroud
authors: Lilia Ben
authors: LB
authors: Fatma
authors: Soumaya
authors: S
authors: Beji
authors: Ahmed
authors: A
authors: Jeribi
authors: H Ben
authors: HB
authors: Maiz
authors: Fatma Ben
authors: FB
authors: Moussa
authors: Rym
authors: R
authors: Goucha
authors: Sami
authors: S
authors: Turki
authors: Adel
authors: A
authors: Kheder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000503:physiopathology*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications* / Q000503:physiopathology*