title: Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.
abstract: We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.
authors: Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101-1709, USA. mcgovepg@umdnj.edu
authors: Peter G
authors: PG
authors: McGovern
authors: Sandra A
authors: SA
authors: Carson
authors: Huiman X
authors: HX
authors: Barnhart
authors: Evan R
authors: ER
authors: Myers
authors: Richard S
authors: RS
authors: Legro
authors: Michael P
authors: MP
authors: Diamond
authors: Bruce R
authors: BR
authors: Carr
authors: William D
authors: WD
authors: Schlaff
authors: Christos
authors: C
authors: Coutifaris
authors: Nicholas A
authors: NA
authors: Cataldo
authors: Michael P
authors: MP
authors: Steinkampf
authors: John E
authors: JE
authors: Nestler
authors: Gabey
authors: G
authors: Gosman
authors: Phyllis C
authors: PC
authors: Leppert
authors: Linda C
authors: LC
authors: Giudice
mesh_terms: D002996:Clomiphene / Q000008:administration & dosage*; D019058:Community Networks; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000188:drug therapy* / Q000453:epidemiology*; D008687:Metformin / Q000008:administration & dosage*; D054582:National Institute of Child Health and Human Development (U.S.); D010349:Patient Compliance / Q000706:statistics & numerical data*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin