Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats.
To establish the effect of dietary omega-3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in omega-3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the omega-3 PUFA deficient diet were significantly more hypertensive than those fed the omega-3 PUFA sufficient diet. Perindopril reduced the blood pressure of both omega-3 PUFA-deficient and omega-3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by omega-3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that omega-3 PUFA may reduce hypertension via the renin-angiotensin system.
Jayasooriya
A P
AP
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
Begg
D P
DP
Chen
N
N
Mathai
M L
ML
Sinclair
A J
AJ
Wilkinson-Berka
J
J
Wark
J D
JD
Weisinger
H S
HS
Weisinger
R S
RS
D000273:Adipose Tissue / Q000187:drug effects; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D006973:Hypertension / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D020913:Perindopril / Q000627:therapeutic use*; D051381:Rats; D012083:Renin / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D015525:Fatty Acids, Omega-3; D000804:Angiotensin II; D012083:Renin; D020913:Perindopril