[Resistance of leukemia cells to Fas/FasL-mediated apoptosis and strategies replying to antiapoptosis of leukemia cells--review].
At angle of cell apoptosis, the excessive less of hematopeitic cell apoptosis is a reason of hematopoietic cell accumulation. The Fas/FasL system as an important pathway inducing cell apoptosis participates in occurrence and development of leukemia. Leukemia cells generally are not sensitive or are resistant to Fas/FasL-mediated apoptosis, while it is one of important reasons resulting in immunoescape and unsensitivity of leukemia cells to chemotherapy. In recent years studies related to mechanisms of leukemia cell resistance to Fas/FasL-mediated apoptosis such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory affect of apoptotic regulatory genes on Fas/FasL system, as well as strategies replying to antiapoptosis of leukemia cells including NF-kappab, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some progresses. The above-mentioned issues were reviewed in this article.
Wang
Li
L
Departmant of Hematology, Center Hospital of Wuhan, Wuhan 430014, China. zouping@public.wh.hb.cn
D017209:Apoptosis / Q000502:physiology*; D018106:CD28 Antigens / Q000378:metabolism; D053222:Fas Ligand Protein / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D014407:Tumor Cells, Cultured; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism; D019014:fas Receptor / Q000502:physiology*
D018106:CD28 Antigens; C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D016328:NF-kappa B; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D019014:fas Receptor; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7