Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions.
Anticonvulsants have been used for the treatment of impulsive aggression since the 1980s. A 50-year-old man suffered from irritability and agitation after developing a right ipsilateral frontal lobe infarction as a result of Moyamoya disease; these symptoms caused difficulties with his working and interpersonal relationships. The patient had been treated using multiple benzodiazepine agents for 2 years but his symptoms had not improved. However, after treatment with carbamazepine (CBZ; 200 mg) was begun, the patient's irritability and agitation gradually decreased. The efficacy of CBZ treatment in this patient suggests a method for controlling benzodiazepine-resistant impulsive aggression.
Nagata
Tomoyuki
T
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan. t.nagata@jikei.ac.jp
Harada
Daisuke
D
Aoki
Kimiyoshi
K
Kada
Hirohide
H
Miyata
Hisatsugu
H
Kasahara
Hiroo
H
Nakayama
Kazuhiko
K
D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D018692:Antimanic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology / Q000523:psychology*; D004351:Drug Resistance; D004569:Electroencephalography; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D007508:Irritable Mood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000150:complications* / Q000473:pathology*; D010292:Paresthesia / Q000188:drug therapy; D011595:Psychomotor Agitation / Q000188:drug therapy / Q000209:etiology
D018692:Antimanic Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D002220:Carbamazepine