Chain-like assembly of gold nanoparticles on artificial DNA templates via 'click chemistry'.
We present a new type of azide-functionalized gold nanoparticle and their coupling to an alkyne-modified DNA duplex using the copper(I)-catalyzed Huisgen cycloaddition ('click chemistry'), resulting in a chain-like assembly of nanoparticles on the DNA template.
Fischler
Monika
M
Institut für Anorganische Chemie, RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany.
Sologubenko
Alla
A
Mayer
Joachim
J
Clever
Guido
G
Burley
Glenn
G
Gierlich
Johannes
J
Carell
Thomas
T
Simon
Ulrich
U
D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D013698:Templates, Genetic
D006046:Gold; D004247:DNA