[Preparation and examination of the vitro releasing of pH-dependent kuijiekang tablet for colon-specific delivery].
OBJECTIVE
To prepare the pH-dependent kuijiekang tablet for colon-specific delivery used in treating the ulcerative colitis and to develop the in vitro release method of kuijiekang tablets.


METHODS
The coating prescription was screened by the in vitro delivery of Puerarin and Berberine hydrochloride. The in-vitro releasing property of the preparation was examined by the method of in-vitro delivery.


RESULTS
The preparation methods of the pH-dependent kuijiekang tablet for colon-specific delivery was obtained from the in-vitro delivery, Puerarin and Berberine hydrochloride were not detected in the simulated gastric fluid after 2 h and the quantitied of Puerarin and Berberine hydrochlo4de were less 10% in the simulated intestinal fluid after 4 h. The quantities of Puerarin and Berberine hydrochloride were 90.07% and 89.87%.


CONCLUSIONS
It can be prepared and the preparation is a promising delivery system for drugs to be delivery to the colon.
Li
Rui-zhen
RZ
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Liao
Hua-wei
HW
Chen
Fei-yuan
FY
D001599:Berberine / Q000737:chemistry; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007529:Isoflavones / Q000737:chemistry; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013678:Technology, Pharmaceutical / Q000379:methods
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D013608:Tablets, Enteric-Coated; C530198:kuijiekang; D001599:Berberine