title: Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
abstract: OBJECTIVE
  To examine the potential role of angiogenesis in leprosy.
  
  
  METHODS
  Immunohistochemical analysis of leprosy lesions.
  
  
  METHODS
  Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.
  
  
  METHODS
  Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.
  
  
  METHODS
  CD31 microvessel counts.
  
  
  RESULTS
  The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.
  
  
  CONCLUSIONS
  Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
authors: Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Dr, Atlanta, GA 30322, USA.
authors: Sulochana S
authors: SS
authors: Bhandarkar
authors: Cynthia
authors: C
authors: Cohen
authors: Maria
authors: M
authors: Kuruvila
authors: Thomas H
authors: TH
authors: Rea
authors: Jamie B
authors: JB
authors: Mackelfresh
authors: Delphine J
authors: DJ
authors: Lee
authors: Robert L
authors: RL
authors: Modlin
authors: Jack L
authors: JL
authors: Arbiser
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007918:Leprosy / Q000150:complications* / Q000188:drug therapy; D015439:Leprosy, Borderline / Q000150:complications; D015440:Leprosy, Lepromatous / Q000150:complications; D015441:Leprosy, Tuberculoid / Q000150:complications; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012867:Skin / Q000098:blood supply*
chemical_list: D020533:Angiogenesis Inhibitors; D019408:Platelet Endothelial Cell Adhesion Molecule-1