title: Successful treatment of meningitis caused by multidrug-resistant Acinetobacter baumannii with intravenous and intrathecal colistin.
abstract: Multidrug-resistant Acinetobacter baumannii is an emergent nosocomial pathogen. A 61-year-old woman developed meningitis caused by MDRAB 27 days after receiving a surgical intervention for invasive meningioma. The patient failed to respond to high doses of meropenem and sulbactam treatment and the organism persisted in the cerebrospinal fluids for two months. The regimen was changed to intravenous and intrathecal colistin for 28 days and the patient responded well. Administration of colistin both intravenously and intrathecally could be a suitable option as a salvage therapy for meningitis due to multidrug-resistant A. baumannii.
authors: Division of Infectious Diseases, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan. yuhuai@tzuchi.com.tw
authors: Yu-Huai
authors: YH
authors: Ho
authors: Lih-Shinn
authors: LS
authors: Wang
authors: Hui-Jen
authors: HJ
authors: Chao
authors: Kia-Chich
authors: KC
authors: Chang
authors: Chain-Fa
authors: CF
authors: Su
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003091:Colistin / Q000008:administration & dosage* / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000134:cerebrospinal fluid / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000601:surgery; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial; D003091:Colistin