Clinical pharmacology and use of microtubule-targeting agents in cancer therapy.
The microtubule-targeting agents have made significant contributions to cancer therapy over the past 50 years. The vinca alkaloids and taxanes have been used to treat a broad range of malignancies, including leukemias and lymphomas and many types of solid tumors. The taxanes have been frequently used in the treatment of advanced ovarian, breast, lung, head and neck, and prostate cancer, and they are increasingly being used in early stage disease. This chapter reviews the pharmacology, clinical indications, and toxicities associated with the vinca alkaloids and taxanes.
Zelnak
Amelia B
AB
Emory University School of Medicine, Atlanta, GA, USA.
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008870:Microtubules / Q000187:drug effects*; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D043823:Taxoids; D014748:Vinca Alkaloids