title: Serum immunosuppressive acidic protein levels in patients with severe acute pancreatitis.
abstract: OBJECTIVE
  In severe acute pancreatitis (SAP), immunologic impairment in the early phase may be linked to subsequent infectious complications. Immunosuppressive acidic protein (IAP) is an immunosuppressive factor to be present in serum and ascites of cancer patients, and it is used as a tumor marker and an index of immune status of cancer hosts.
  
  
  METHODS
  We measured serum IAP levels in 42 patients with SAP (Japanese severity score [JSS] > or = 2) on admission and analyzed the relationships with disease severity, pancreatic necrosis, blood biochemical parameters on admission, and clinical outcome (infection and death).
  
  
  RESULTS
  Serum IAP level increased 791 +/- 285 microg/mL (range, 159-1430 microg/mL) on admission and recognized abnormal high level (normal range, < 500 microg/mL) in 37 patients (88.1%). Serum IAP level was significantly lower in patients of stages 3 and 4 (JSS > or = 9) (678 +/- 187 microg/mL) than that in patients of stage 2 (2 < or = JSS < or = 8) (848 +/- 311 microg/mL). It was also significantly lower in patients whose Ranson score was 5 or higher (674 +/- 287 microg/mL) than that in patients whose Ranson score was 4 or less (910 +/- 287 microg/mL). Moreover, it was significantly lower in patients with pancreatic necrosis (693 +/- 194 microg/mL) than that in patients without pancreatic necrosis (922 +/- 336 microg/mL). Among the blood biochemical parameters on admission, serum IAP was significantly negatively correlated with hematocrit, serum lipase, and serum interferon gamma and was significantly positively correlated with serum total protein. Serum IAP levels in patients of stage 2 reached higher peak at 7 days after admission and decreased more rapidly than those in patients of stages 3 and 4.
  
  
  CONCLUSIONS
  Serum IAP levels were elevated in patients with SAP but were significantly lower in patients with higher grade of severity or pancreatic necrosis. These results suggest that serum IAP levels may be related to systemic inflammatory response and reflect the immunoresponsiveness in patients with SAP.
authors: Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe, Japan. shinzeki@med.kobe-u.ac.jp
authors: Makoto
authors: M
authors: Shinzeki
authors: Takashi
authors: T
authors: Ueda
authors: Yoshifumi
authors: Y
authors: Takeyama
authors: Takeo
authors: T
authors: Yasuda
authors: Hidehiro
authors: H
authors: Sawa
authors: Takahiro
authors: T
authors: Nakajima
authors: Ippei
authors: I
authors: Matsumoto
authors: Tsunenori
authors: T
authors: Fujita
authors: Tetsuo
authors: T
authors: Ajiki
authors: Yasuhiro
authors: Y
authors: Fujino
authors: Yoshikazu
authors: Y
authors: Kuroda
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009363:Neoplasm Proteins / Q000097:blood*; D010195:Pancreatitis / Q000097:blood / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D010343:Patient Admission; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D020382:Interleukin-18; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein; D007371:Interferon-gamma; D008049:Lipase; C518354:PNLIP protein, human