Synthesis of C8-modified 2''-deoxyadenosine with carcinogenic arylamines.
The synthesis of phosphoramidites of C8-modified 2'-deoxyadenosine with carcinogenic arylamines p-anisidine and 4-aminobiphenyl is described. Two different methods were studied related to the glycon and base protection groups.
Jacobsen
M I
MI
Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King Platz 6, D-20146 Hamburg, Germany.
Meier
C
C
D000588:Amines / Q000737:chemistry; D002273:Carcinogens / Q000138:chemical synthesis* / Q000737:chemistry; D018736:DNA Adducts / Q000138:chemical synthesis* / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D000588:Amines; D002273:Carcinogens; D018736:DNA Adducts; D003839:Deoxyadenosines; D009943:Organophosphorus Compounds; C434331:phosphoramidite; C058118:2'-deoxyadenosine