title: Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.
abstract: Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.
authors: M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030-3930, USA. dkontoyi@mdanderson.org
authors: Dimitrios P
authors: DP
authors: Kontoyiannis
authors: Russell E
authors: RE
authors: Lewis
authors: Barbara D
authors: BD
authors: Alexander
authors: Olivier
authors: O
authors: Lortholary
authors: Françoise
authors: F
authors: Dromer
authors: Krishan L
authors: KL
authors: Gupta
authors: George T
authors: GT
authors: John
authors: Ramon
authors: R
authors: Del Busto
authors: Goran B
authors: GB
authors: Klintmalm
authors: Jyoti
authors: J
authors: Somani
authors: G Marshall
authors: GM
authors: Lyon
authors: Kenneth
authors: K
authors: Pursell
authors: Valentina
authors: V
authors: Stosor
authors: Patricia
authors: P
authors: Munoz
authors: Ajit P
authors: AP
authors: Limaye
authors: Andre C
authors: AC
authors: Kalil
authors: Timothy L
authors: TL
authors: Pruett
authors: Julia
authors: J
authors: Garcia-Diaz
authors: Atul
authors: A
authors: Humar
authors: Sally
authors: S
authors: Houston
authors: Andrew A
authors: AA
authors: House
authors: Dannah
authors: D
authors: Wray
authors: Susan
authors: S
authors: Orloff
authors: Lorraine A
authors: LA
authors: Dowdy
authors: Robert A
authors: RA
authors: Fisher
authors: Joseph
authors: J
authors: Heitman
authors: Nathaniel D
authors: ND
authors: Albert
authors: Marilyn M
authors: MM
authors: Wagener
authors: Nina
authors: N
authors: Singh
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D065095:Calcineurin Inhibitors; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D016377:Organ Transplantation / Q000009:adverse effects*; D016559:Tacrolimus / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus