title: Biological scaffolds for heart valve tissue engineering.
abstract: Tissue engineering might bear promising solutions for overcoming the limitations of biological and mechanical heart valve substitutes. The concept of heart valve tissue engineering bases on decellularized biological matrices, as removal of cellular components might reduce immunological reactions, which are thought to be responsible for accelerated valvular graft deterioration and their subsequent repopulation with autologous cells, which leads to tissue integrity and continuous remodeling. Here, we report a method for efficient removal of cells from ovine heart valve tissue (including cusp, wall, and myocardial cuff) by detergents for the generation of biological valvular scaffolds.
authors: Department of Thoracic and Cardiovascular Surgery, Hanover Medical School, Germany.
authors: Artur
authors: A
authors: Lichtenberg
authors: Serghei
authors: S
authors: Cebotari
authors: Igor
authors: I
authors: Tudorache
authors: Andres
authors: A
authors: Hilfiker
authors: Axel
authors: A
authors: Haverich
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D001705:Bioprosthesis; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006350:Heart Valve Prosthesis; D006351:Heart Valves / Q000033:anatomy & histology*; D006801:Humans; D011474:Prosthesis Design; D051381:Rats; D012756:Sheep; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials