Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?
Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.
Matrat
Stéphanie
S
Université Pierre et Marie Curie-Paris 6, Paris, France.
Cambau
Emmanuelle
E
Jarlier
Vincent
V
Aubry
Alexandra
A
D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027081:DNA Gyrase