The clinical impact and incidence of periocular pigmentation associated with either latanoprost or bimatoprost therapy.
OBJECTIVE
To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost.


METHODS
A retrospective, active-controlled comparison of consecutive patients treated with latanoprost or bimatoprost for 12 months evaluating patients to determine the incidence, characteristics, and reversibility of periocular pigmentation.


RESULTS
Periocular pigmentation was found in 1% patients treated with latanoprost and 6% patients treated with bimatoprost within 12 months of beginning treatment (p = 0.004).


CONCLUSIONS
This study suggests that periocular pigmentation may develop after treatment with latanoprost or bimatoprost.
Sharpe
Elizabeth D
ED
Glaucoma Consultants and Center For Eye Research, Mount Pleasant, South Carolina, USA.
Reynolds
Adam C
AC
Skuta
Gregory L
GL
Jenkins
Jessica N
JN
Stewart
William C
WC
D000328:Adult; D000368:Aged; D000577:Amides / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D000069580:Bimatoprost; D003008:Cloprostenol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005127:Eye Color / Q000187:drug effects; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008055:Lipids / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000503:physiopathology; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*; D012189:Retrospective Studies; D012880:Skin Pigmentation / Q000187:drug effects*; D014065:Tonometry, Ocular
D000577:Amides; D000959:Antihypertensive Agents; D008055:Lipids; D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D000077338:Latanoprost; D000069580:Bimatoprost