Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer disease.
Hypertension in an 83-year-old woman with early Alzheimer disease was treated with a calcium channel blocker, nilvadipine, for 3 months. Before and after nilvadipine treatment, global and regional cerebral blood flow (gCBF and rCBF) were measured using Tc-99m ethyl cysteinate dimer SPECT. This treatment elevated both the Mini-Mental State Examination score from 23 to 27 and gCBF from 37.6 to 42.0 mL/100 g/min. This treatment also elevated rCBF prominently in the bilateral frontal cortex, right parietal cortex, and posterior cingulate cortex. These areas with rCBF increase generated by subtraction of pretreatment SPECT from post-treatment SPECT were demonstrated on a coregistered MRI.
Matsuda
Hiroshi
H
Department of Nuclear Medicine, Saitama Medical University Hospital, Saitama, Japan. matsudah@saitama-med.ac.jp
Araki
Nobuo
N
Kuji
Ichiei
I
Ohkubo
Takeshi
T
Imabayashi
Etsuko
E
Shimazu
Kunio
K
D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003545:Cysteine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon
D000959:Antihypertensive Agents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C035100:nilvadipine; C059659:technetium Tc 99m bicisate; D009543:Nifedipine; D003545:Cysteine