title: Preoperative flurbiprofen for pain prevention after tonsillectomy in adults.
abstract: OBJECTIVE
  To investigate the analgesic efficacy of preoperative flurbiprofen on postoperative pain after tonsillectomy.
  
  
  METHODS
  Prospective, randomized, nonblinded, non-placebo-controlled study.
  
  
  METHODS
  Municipal hospital.
  
  
  METHODS
  Twenty-five ASA physical status I patients older than 20 years of age, who were scheduled for tonsillectomy.
  
  
  METHODS
  Patients were randomly allocated to two groups to receive preoperative intravenous (IV) 50 mg flurbiprofen (group F) or not (group C). Anesthesia was induced with IV propofol two mg/kg and maintained with nitrous oxide and sevoflurane.
  
  
  METHODS
  Pain scores at rest and at swallowing, intraoperative bleeding, vital signs during the postanesthetic period, interval until diclofenac sodium suppository rescue, and the total dose required for 12 hours postoperatively were all recorded.
  
  
  RESULTS
  Pain scores at rest as well as those recorded after swallowing 30 minutes after tonsillectomy were significantly lower in group F than in group C. During the first postoperative 1.5 hours, significantly fewer patients in group F required rescue diclofenac suppository than did group C patients. However, total dose of required rescue during the postoperative 12 hours in group F did not significantly differ from that of group C. There were no significant differences in intraoperative bleeding or in any vital signs during the postanesthetic period either.
  
  
  CONCLUSIONS
  Preoperative flurbiprofen suppressed immediate postoperative pain after tonsillectomy. The analgesic effect, however, disappeared in a few hours and was insufficient for overnight pain relief.
authors: Department of Otolaryngology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. nishiike@med.kawasaki-m.ac.jp
authors: Suetaka
authors: S
authors: Nishiike
authors: Takashi
authors: T
authors: Kato
authors: Miki
authors: M
authors: Nagai
authors: Aya
authors: A
authors: Nakagawa
authors: Masaki
authors: M
authors: Konishi
authors: Yoshiharu
authors: Y
authors: Sakata
authors: Fumihiko
authors: F
authors: Shimada
authors: Hideki
authors: H
authors: Kida
authors: Masato
authors: M
authors: Ota
authors: Tamotsu
authors: T
authors: Harada
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D010147:Pain Measurement / Q000706:statistics & numerical data; D010149:Postoperative Pain / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors; D014068:Tonsillectomy / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D005480:Flurbiprofen