title: [Resistance to azolic compounds in clinical Trichophyton spp. strains].
abstract: The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.
authors: Laboratorio de Investigación Médica en Dermatología y Micología "Dr. Ernesto Macotela", Hospital de Especialidades "Dr. Bernardo Sepúlveda", UMAE Centro Médico Nacional Siglo XXI, IMSS, México D.F., México. ljmt@servidor.unam.mx
authors: Luis Javier
authors: LJ
authors: Méndez-Tovar
authors: Patricia
authors: P
authors: Manzano-Gayosso
authors: Verónica
authors: V
authors: Velásquez-Hernández
authors: Blanca
authors: B
authors: Millan-Chiu
authors: Francisca
authors: F
authors: Hernández-Hernández
authors: Rafael
authors: R
authors: Mondragón-González
authors: Rubén
authors: R
authors: López-Martínez
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D025141:Drug Resistance, Fungal; D026141:Drug Resistance, Multiple, Fungal; D004821:Epidermophyton / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008800:Mexico; D008864:Microsporum / Q000187:drug effects / Q000302:isolation & purification; D014009:Onychomycosis / Q000382:microbiology; D014005:Tinea / Q000382:microbiology*; D014006:Tinea Capitis / Q000382:microbiology; D014008:Tinea Pedis / Q000382:microbiology; D014249:Trichophyton / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole; D007654:Ketoconazole