Some novel adenosine mimics: synthesis and anticancer potential against cervical cancer caused by human papilloma virus.
Two novel adenosine analogs, viz. 9-(1'-beta-D-arabinofuranosyl)-6-nitro-1,3-dideazapurine or Ara-NDDP (1) and 9-(5'-deoxy-5'-S-(propionic acid) (1'-beta-D-ribofuranosyl) adenine or SAH analog (2), indigenously synthesized, have been found to be potential anticancer agents against cervical cancer caused by human papilloma virus.
Sinha
Sarika
S
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India.
Srivastava
Richa
R
Prusty
Bhupesh
B
Das
B C
BC
Singh
Ramendra K
RK
D000241:Adenosine / Q000138:chemical synthesis* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D018716:Molecular Mimicry / Q000187:drug effects; D027383:Papillomaviridae / Q000187:drug effects / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000821:virology*
D000970:Antineoplastic Agents; D000241:Adenosine