Porphyrin-DNA: a supramolecular scaffold for functional molecules on the nanometre scale.
We are pursuing the aim to use DNA as a supramolecular scaffold for the creation of electronically functional molecules on the nanometre scale. Here, we give a review on our results on porphyrin modified nucleotides used for this purpose. A general synthetic route to porphyrin-nucleotides has been devised, and the building blocks can be incorporated into oligonucleotides using standard solid phase synthesis methods. Up to 11 porphyrins were incorporated into DNA, reaching a length of approximately 4 nm in the array. The spectroscopic data are consistent with a porphyrin induced secondary structure stabilisation in the single strands.
Bouamaied
Imenne
I
Department of Chemistry, University of Basel, Basel, Switzerland.
Fendt
Leslie-Anne
LA
Häussinger
Daniel
D
Wiesner
Markus
M
Thöni
Sandra
S
Amiot
Nicolas
N
Stulz
Eugen
E
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*
D009711:Nucleotides; D011166:Porphyrins; D004247:DNA