Graded arrangement of collagen fibrils in the equine superficial digital flexor tendon.
By using ultramorphological and biochemical methods, we analyzed the regional differences between the three parts of the equine superficial digital flexor tendon (SDFT), namely, the myotendinous junction (MTJ), middle metacarpal (mM), and osteotendinous junction (OTJ). Cross-sectional images showed unique distributions of collagen fibrils of varying diameters in each region. Small collagen fibrils (diameter <100 nm) were distributed predominantly in the MTJ region, and the OTJ region was relatively rich in large collagen fibrils (diameter >200 nm). In the mM region, the collagen fibrils were intermediately distributed between the MTJ and OTJ. The results indicate a graded arrangement of collagen fibrils in the tendon. Type V collagen was detected preferentially in the MTJ region. Since type V collagen is believed to be one of the collagens regulating collagen fibril formation, its possible functionality in the MTJ region in terms of fibril formation and fibril arrangement in the tendon has been discussed here.
Watanabe
Takafumi
T
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Imamura
Yasutada
Y
Hosaka
Yoshinao
Y
Ueda
Hiromi
H
Takehana
Kazushige
K
D000818:Animals; D003094:Collagen / Q000648:ultrastructure*; D024042:Collagen Type I / Q000648:ultrastructure; D024061:Collagen Type III / Q000648:ultrastructure; D024062:Collagen Type V / Q000648:ultrastructure; D005552:Forelimb / Q000033:anatomy & histology; D006736:Horses / Q000033:anatomy & histology*; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D013710:Tendons / Q000648:ultrastructure*
D024042:Collagen Type I; D024061:Collagen Type III; D024062:Collagen Type V; D003094:Collagen