title: The Arabidopsis circadian clock incorporates a cADPR-based feedback loop.
abstract: Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
authors: Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
authors: Antony N
authors: AN
authors: Dodd
authors: Michael J
authors: MJ
authors: Gardner
authors: Carlos T
authors: CT
authors: Hotta
authors: Katharine E
authors: KE
authors: Hubbard
authors: Neil
authors: N
authors: Dalchau
authors: John
authors: J
authors: Love
authors: Jean-Maurice
authors: JM
authors: Assie
authors: Fiona C
authors: FC
authors: Robertson
authors: Mia Kyed
authors: MK
authors: Jakobsen
authors: Jorge
authors: J
authors: Gonçalves
authors: Dale
authors: D
authors: Sanders
authors: Alex A R
authors: AA
authors: Webb
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D002940:Circadian Rhythm / Q000235:genetics; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D025461:Feedback, Physiological; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D009536:Niacinamide / Q000494:pharmacology; D018515:Plant Leaves / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D036563:Cyclic ADP-Ribose; D009536:Niacinamide; D002118:Calcium