Six cadm/SynCAM genes are expressed in the nervous system of developing zebrafish.
The Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development.
Pietri
Thomas
T
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA.
Easley-Neal
Courtney
C
Wilson
Catherine
C
Washbourne
Philip
P
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000145:classification / Q000235:genetics*; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D020033:Protein Isoforms / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D015027:Zebrafish / Q000235:genetics* / Q000254:growth & development; D029961:Zebrafish Proteins / Q000235:genetics*
D015815:Cell Adhesion Molecules; D020033:Protein Isoforms; D029961:Zebrafish Proteins