Changes in serum fetuin-A and inflammatory markers levels in end-stage renal disease (ESRD): effect of a single session haemodialysis.
BACKGROUND
The aim of the present study was to evaluate the effect of a single haemodialysis (HD) session on serum fetuin-A levels, considered a negative acute phase response marker; moreover, we evaluated the behaviour of fibrinogen and high sensitivity C-reactive protein (hsCRP) as acute phase response and chronic/subclinical inflammation markers, respectively, after a single HD session.


METHODS
Serum fetuin-A, albumin, hsCRP and fibrinogen were measured in 72 patients before and after a single HD session.


RESULTS
After a single HD session, we observed a significant increase in fibrinogen levels, while fetuin-A levels decreased (p<0.05). Also, hsCRP levels were significantly increased.


CONCLUSIONS
The significant decrease of fetuin-A levels after a single HD session is consistent with the hypothesis of HD-induced inflammation; activated acute phase response and fetuin-A deficiency might account for increased cardiovascular risk and accelerated atherogenesis in dialysis patients.
Ciaccio
Marcello
M
Clinical Biochemistry, Faculty of Medicine, University of Palermo, Palermo, Italy. marcello.ciaccio@unipa.it
Bivona
Giulia
G
Di Sciacca
Riccardo
R
Iatrino
Rossella
R
Di Natale
Epifanio
E
Li Vecchi
Maurizio
M
Bellia
Chiara
C
D000368:Aged; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D000509:alpha-Fetoproteins / Q000032:analysis*
D018836:Inflammation Mediators; D000509:alpha-Fetoproteins