title: Novel biostable and biocompatible amphiphilic membranes.
abstract: We determined the biostability and biocompatibility of two types of amphiphilic conetworks (APCNs): (1) hydrophilic poly(N,N-dimethyl acrylamide) (PDMAAm) and hydrophobic polydimethylsiloxane (PDMS) microdomains co-crosslinked with polymethylhydrosiloxane (PMHS) clusters (PDMAAm/PMHS/PDMS), and (2) poly(ethylene glycol) (PEG) and PDMS microdomains co-crosslinked with two specially designed small-molecule crosslinking agents SiC(6)H(5)(SiH)(2)OEt (Y) and polypentamethylhydrocyclosiloxane (PD(5)) (PEG/Y or PD(5)/PDMS). Negative standards for comparing biocompatibility and biostability were crosslinked PDMS. Biostability was assessed by quantitatively determining extractables, equilibrium water swelling, mechanical properties (stress-strain response) of polymer samples before and after implantation in rats for up to 8 weeks, and oxidative accelerated degradation test. Biocompatibility was assessed by determining body weight, fibrous tissue encapsulation, fluid accumulation, and by histological evaluation of lymphocyte infiltration, fibrous tissue accumulation and collagen deposition. According to these stringent metrics PDMAAm/PMHS/PDMS is both biostable and biocompatible, whereas PEG/Y or PD(5)/PDMS degrades in living tissue but is biocompatible. Surprisingly, the overall biocompatibility scores of these APCNs were superior to those of the PDMS negative standard.
authors: Institute of Polymer Science, The University of Akron, Akron, Ohio 44325, USA.
authors: Suresh K
authors: SK
authors: Jewrajka
authors: Gabor
authors: G
authors: Erdodi
authors: Joseph P
authors: JP
authors: Kennedy
authors: Daniel
authors: D
authors: Ely
authors: Gail
authors: G
authors: Dunphy
authors: Shannon
authors: S
authors: Boehme
authors: Flavius
authors: F
authors: Popescu
mesh_terms: D000178:Acrylamides / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001673:Biodegradation, Environmental; D001835:Body Weight; D003094:Collagen / Q000187:drug effects / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000494:pharmacology; D004129:Dimethylpolysiloxanes / Q000737:chemistry / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D009132:Muscles / Q000166:cytology / Q000187:drug effects; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D012833:Siloxanes / Q000737:chemistry / Q000494:pharmacology; D013718:Tensile Strength
chemical_list: D000178:Acrylamides; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D012833:Siloxanes; C429790:poly(N,N-dimethylacrylamide); C402373:poly(methylhydrosiloxane); D011092:Polyethylene Glycols; C013830:baysilon; D003094:Collagen