title: Study of different copper (I) catalysts for the "click chemistry" approach to carbanucleosides.
abstract: We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acetonitrile)copper hexafluorophosphate ([Cu(CH3CN)4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method.
authors: Institut de Chimie Organique et Analytique, Université d'Orléans, Orléans, France.
authors: Julie
authors: J
authors: Broggi
authors: Nicolas
authors: N
authors: Joubert
authors: Vincent
authors: V
authors: Aucagne
authors: Thomas
authors: T
authors: Zevaco
authors: Sabine
authors: S
authors: Berteina-Raboin
authors: Steve P
authors: SP
authors: Nolan
authors: Luigi A
authors: LA
authors: Agrofoglio
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D008872:Microwaves; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D009705:Nucleosides; D003300:Copper