Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates.
Conjugation of ubiquitin regulates multiple pathways, including the signaling cascades leading to antiviral immunity. Similarly, the ubiquitin-like peptide ISG15 mediates the antiviral response to certain viruses. In this issue of Cell Host & Microbe, Frias-Staheli and colleagues demonstrate that research on viral proteases of certain nairoviruses and arteriviruses reveals the presence of ovarian tumor domain-containing sequences that act as general deubiquitinases and deISGylases and increase viral replication by inhibiting the antiviral response mediated by ISG15.
Arguello
Meztli D
MD
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal H3T 1E2, Canada.
Hiscott
John
J
D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology; D015398:Signal Transduction; D014452:Ubiquitins / Q000276:immunology / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D009363:Neoplasm Proteins; D014452:Ubiquitins; D014764:Viral Proteins; C074034:ISG15 protein, human; D010447:Peptide Hydrolases