Is general anesthesia a risk for myocardium? Effect of anesthesia on myocardial function as assessed by cardiac troponin-i in two different groups (isofluran+N2O inhalation and propofol+fentanyl iv anesthesia).
OBJECTIVE
Peroperative myocardial infarction (MI) is the most common cause of morbidity and mortality. What is the role of general anesthesia in this process? Is general anesthesia a risk for myocardial infarction? The present study was designed to determine whether the measurement of serum levels of cardiac troponin I (cTnI), a highly sensitive and specific marker for cardiac injury, would help establish the diagnosis of myocardial infarction in two different types of anesthesia.


METHODS
Elective abdominal hysterectomy was planned with the permission of the ethic committee in 40 patients who were 20-45 years range, in ASA-I group, and have a Goldman Cardiac Risk Index-0. The patients were divided into two groups. Isoflurane + N2O was administrated to first group, and Propofol + Fentanyl to second group. cTnI levels were determined before anesthesia, after induction before surgery and 9 hours after the second period respectively.


RESULTS
There was no significant difference between the groups by the means of demographic properties, hemodynamic parameters and cTnI levels, and the cTnI levels were determined under the basal levels in all samples.


CONCLUSIONS
General anesthesia is not a risk for myocardial infarction to state eliminating risk factors and protection hemodynamia cardiac.
Erol
Demet Dogan
DD
Department of Anaesthesiology and Reanimation, School of Medicine, Kocatepe University, Afyonkarahisar, Turkey. demetdoganerol@mynet.com
Ozen
Ibrahim
I
D000328:Adult; D000768:Anesthesia, General; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D001239:Inhalation / Q000187:drug effects; D007275:Injections, Intravenous; D007530:Isoflurane / Q000494:pharmacology*; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D019210:Troponin I / Q000097:blood*
D019210:Troponin I; D007530:Isoflurane; D009585:Nitrogen Dioxide; D005283:Fentanyl; D015742:Propofol