Thymoma with ganglioneuroblastomatous component: case report.
A mediastinal tumor in a 49-year-old woman with myasthenia gravis is reported. The tumor was well-demarcated and located in the supero-anterior mediastinum. Microscopically, the tumor consisted of thymic and neuroblastic tumor components, the latter of which consisted of immature and maturing neuronal cells, abundant neuropils, and Schwannian stroma. The two components intermingled with each other inside the tumor capsule. The tumor was diagnosed as thymoma with a ganglioneuroblastomatous component. The coexistence of epithelial and neuronal tissues in the thymic neoplasm is extremely rare.
Kashiwabara
Kenji
K
Department of Clinical Pathology, Saiseikai Maebashi Hospital, 564-1 Kamishinden-machi, Maebashi, Gunma, 371-0821, Japan. ke-kashiwabara@maebashi.saiseikai.or.jp
Ikota
Hayato
H
Tanaka
Shigebumi
S
Ohta
Chie
C
Yajima
Toshiki
T
Endoh
Hideki
H
Yamaki
Ei
E
Kuwano
Hiroyuki
H
Nakajima
Takashi
T
D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D018305:Ganglioneuroblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000378:metabolism / Q000473:pathology; D013934:Thymectomy; D013945:Thymoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D000071443:12E7 Antigen; D015703:Antigens, CD; D017252:CD3 Complex; D018956:CD5 Antigens; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D007633:Keratins