Alkaline phosphatase: keeping the peace at the gut epithelial surface.
Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.
Vaishnava
Shipra
S
Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Hooper
Lora V
LV
D000469:Alkaline Phosphatase / Q000502:physiology*; D000818:Animals; D018407:Bacterial Physiological Phenomena; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology* / Q000502:physiology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008871:Microvilli / Q000201:enzymology
D008070:Lipopolysaccharides; D000469:Alkaline Phosphatase