Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction.
Several viruses, including influenza, induce an imbalance of intracellular redox state toward pro-oxidant conditions. Through different mechanisms these alterations contribute both to influenza virus replication and to the pathogenesis of virus-induced disease. At the same time, influenza virus activates several intracellular signaling pathways involved in important physiological functions of the cell. Interestingly, many of these pathways are finely regulated by small changes in intracellular redox state, and the virus-induced redox imbalance might also control viral replication through this mechanism. Here we review the main intracellular redox-sensitive pathways activated upon influenza infection and involved in regulating viral replication.
Nencioni
Lucia
L
G. Sanarelli Department of Public Health Sciences, La Sapienza University of Rome, Italy.
Sgarbanti
Rossella
R
De Chiara
Giovanna
G
Garaci
Enrico
E
Palamara
Anna Teresa
AT
D000818:Animals; D000890:Anti-Infective Agents; D015195:Drug Design; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000378:metabolism* / Q000821:virology*; D010084:Oxidation-Reduction; D015398:Signal Transduction; D014779:Virus Replication
D000890:Anti-Infective Agents; D020928:Mitogen-Activated Protein Kinases