Fungal Recognition by TLR2 and Dectin-1.
The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1. Examination of the roles these receptors play together and on their own is a useful model for understanding the interplay between innate immune receptors. This review focuses on the role(s) of TLR2 and Dectin-1 in triggering inflammatory responses, transcription factor activation, phagocytosis, and reactive oxygen production in response to fungi.
Goodridge
Helen S
HS
Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. helen.goodridge@cshs.org
Underhill
David M
DM
D000818:Animals; D005658:Fungi / Q000276:immunology / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000502:physiology*; D000099181:Dectin-1
D018836:Inflammation Mediators; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017382:Reactive Oxygen Species; D051195:Toll-Like Receptor 2; D000099181:Dectin-1