title: Identification of group 1 coronavirus antigen in multisystemic granulomatous lesions in ferrets (Mustela putorius furo).
abstract: Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions.
authors: Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain. jorge.martinez.martinez@uab.es
authors: J
authors: J
authors: Martínez
authors: M
authors: M
authors: Reinacher
authors: D
authors: D
authors: Perpiñán
authors: A
authors: A
authors: Ramis
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification*; D017934:Coronavirus / Q000302:isolation & purification*; D018352:Coronavirus Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005289:Ferrets / Q000821:virology*; D006099:Granuloma / Q000662:veterinary* / Q000821:virology*; D007150:Immunohistochemistry; D008297:Male; D012189:Retrospective Studies
chemical_list: D000956:Antigens, Viral