Risk factors for pre-eclampsia in pregnant Chinese women with abnormal glucose metabolism.
OBJECTIVE
To investigate the incidence and risk factors for pre-eclampsia in pregnant Chinese women with abnormal glucose metabolism.


METHODS
A retrospective cohort study was performed on 1499 pregnant women with abnormal glucose metabolism at Peking University First Hospital from January 1995 to December 2004.


RESULTS
The overall prevalence of pre-eclampsia in women with abnormal glucose metabolism was 9.4% (141/1499). The prevalence of pre-eclampsia in women diagnosed with diabetes mellitus prior to pregnancy was higher than that of gestational diabetes mellitus and gestational impaired glucose tolerance patients (29.1% vs 8.7% and 7.8%, P<0.01). Pre-pregnancy body mass index was significantly higher in women with pre-eclampsia than in those without. A higher rate of pre-eclampsia was found in women with chronic hypertension and those with poor glucose control. The independent risk factors for pre-eclampsia were chronic hypertension and elevated pre-pregnancy body mass index.


CONCLUSIONS
The type of diabetes, chronic hypertension, and elevated pre-pregnancy body mass index are high risk factors for pre-eclampsia in pregnant women with abnormal glucose metabolism.
Sun
Yu
Y
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Yang
Huixia
H
Sun
Wei Jie
WJ
D000328:Adult; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D044882:Glucose Metabolism Disorders / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D015994:Incidence; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors