[LDL cholesterol--why lower and lower?].
Large interventional studies with statins have confirmed that drug-lowering of LDL cholesterol by at least 25-30% is associated with a significant reduction in the cardiovascular risk. In high-risk patients, the plasma LDL cholesterol level should be < 100 mg/dl. If the levels are initially low, the aim is to achieve a reduction of at least 30-40%. More recent studies have shown that reducing the LDL cholesterol to < 70 mg/dl can stop the further growth of plaques, and can possibly even bring about their regression.
Müller-Wieland
Dirk
D
I. Medizinischen Abt. Asklepios Klinik St. Georg, Hamburg. dirk.mueller-wieland@ak-stgeorg.lbk-hh.de
Kotzka
J
J
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000188:drug therapy; D009203:Myocardial Infarction / Q000097:blood / Q000517:prevention & control*; D012016:Reference Values; D012307:Risk Factors
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors