title: Sleep symptoms and gastroesophageal reflux.
abstract: BACKGROUND
  This study was to determine whether patients with significant nighttime heartburn had more disturbed sleep and more gastroesophageal acid reflux than those without significant nighttime heartburn.
  
  
  METHODS
  Thirty-three reflux patients were stratified into 2 groups (nighttime heartburn, without nighttime heartburn). All patients completed questionnaires assessing daytime and nighttime heartburn and subjective sleep by Pittsburgh Sleep Quality Index. All participants underwent 24-hour esophageal pH monitoring and an overnight polysomnographic study.
  
  
  RESULTS
  The number of reflux events longer than 5 minutes was significantly greater in patients with nighttime heartburn than in those without nighttime heartburn for the total (P=0.004) and upright (P=0.01) position periods. Acid contact time was significantly greater in patients with nighttime heartburn during the upright (P=0.003) period and during the total (P=0.001) period. Patients with nighttime heartburn reported significantly greater subjective sleep impairment (8.1+/-0.7) than those without nighttime heartburn (6.1+/-0.4; P=0.02), but no difference could be observed in any objective sleep parameter by an overnight polysomnographic study between the groups.
  
  
  CONCLUSIONS
  Patients with significant nighttime heartburn seem to have more acid reflux compared with those without nighttime heartburn. Nighttime heartburn together with sleep complaints is associated with excessive gastroesophageal reflux.
authors: Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien, Taiwan. harry.clchen@msa.hinet.net
authors: Chien-Lin
authors: CL
authors: Chen
authors: Jennifer J T
authors: JJ
authors: Robert
authors: William C
authors: WC
authors: Orr
mesh_terms: D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology*; D006356:Heartburn / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology / Q000503:physiopathology*; D011795:Surveys and Questionnaires