Assessment of the predictive value of serum progesterone levels on early pregnancy prognosis in spontaneous twin gestations: a prospective study.
OBJECTIVE
The aim of this study was to assess the predictive value of serum progesterone levels in early pregnancy prognosis in spontaneous dichorionic-diamniotic twin gestations.


METHODS
This study was carried out among 38 spontaneous dichorionic-diamniotic twin gestations between January 2003 and June 2005 in the Department of Obstetrics and Gynaecology at the Gulhane Military Medical Academy. Serum progesterone levels were measured at 7 and 10 weeks' gestation and pregnancies were followed until 14 gestational weeks by ultrasound examination.


RESULTS
We found that a progesterone level of 58 nmol/l in the 7th gestational week and of 51 ng/ml at 10 gestational weeks has a predictive value for viable intrauterine twin pregnancies with 83% sensitivity and 69% specificity and 83% sensitivity and 84% specificity, respectively.


CONCLUSIONS
Progesterone levels in the early gestational weeks may be a biochemical marker for the prediction of a twin pregnancy outcome and may reduce the number of ultrasound examinations.
Goktolga
Umit
U
Department of Obstetrics and Gynaecology, Gulhane Military Medical Academy and Medical School, Ankara, Turkey. ugoktolga@yahoo.com <ugoktolga@yahoo.com>
Gungor
Sadettin
S
Ceyhan
Seyit Temel
ST
Keskin
Ugur
U
Fidan
Ulas
U
Gezginc
Kazim
K
Baser
Iskender
I
D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood*; D011272:Pregnancy, Multiple / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal
D015415:Biomarkers; D011374:Progesterone