(BDP)CuH: a "hot" Stryker's reagent for use in achiral conjugate reductions.
A ligand-modified, economical version of Stryker's reagent (SR) has been developed based on a bidentate, achiral bis-phosphine. Generated in situ, "(BDP)CuH" smoothly effects conjugate reductions of a variety of unsaturated substrates, including those that are normally unreactive toward SR. Substrate-to-ligand ratios typically on the order of 1000-10000:1 can be used leading to products in high yields.
Baker
Benjamin A
BA
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Bosković
Zarko V
ZV
Lipshutz
Bruce H
BH