Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages.
3 '-S-Phosphorothiolate linkages incorporated into an oligodeoxynucleotide have been shown to stabilise duplex formation with a complementary RNA strand, but destabilise a duplex formed with a complementary DNA strand. The four-stranded i-motif structure is also stabilised this modification.
Cosstick
Richard
R
Department of Chemistry, University of Liverpool, Liverpool, United Kingdom. rcosstic@liv.ac.uk
Buckingham
Joanne
J
Brazier
John
J
Fisher
Julie
J
D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*
C465503:3'-S-phosphorothiolate; D009692:Nucleic Acid Heteroduplexes; D009696:Nucleic Acids; D009841:Oligonucleotides; D010710:Phosphates