Dexamethasone suppression test in borderline personality disorder: impact of PTSD symptoms.
The purpose of the present study was to investigate the impact of post-traumatic stress disorder (PTSD) symptoms on hypothalamic-pituitary-adrenal axis feedback regulation in 18 female patients with borderline personality disorder (BPD) and 21 healthy controls. Reduced feedback sensitivity was found in BPD patients with a low number of PTSD symptoms, while findings in the BPD group with a high number of PTSD symptoms did not differ from those in controls. The results suggest a hypo-suppression in the dexamethasone suppression test in BPD with few PTSD symptoms.
Wingenfeld
Katja
K
Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany. katja.wingenfeld@evkb.de
Hill
Andreas
A
Adam
Bettina
B
Driessen
Martin
M
D000328:Adult; D001883:Borderline Personality Disorder / Q000097:blood / Q000503:physiopathology* / Q000523:psychology*; D002648:Child; D002649:Child Abuse / Q000523:psychology; D002650:Child Abuse, Sexual / Q000523:psychology; D003907:Dexamethasone; D025461:Feedback, Physiological; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000503:physiopathology* / Q000523:psychology*; D011795:Surveys and Questionnaires
D003907:Dexamethasone; D006854:Hydrocortisone