New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus.
Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).
Kito
Keijiro
K
Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.
Ookura
Ryuhei
R
Yoshida
Sanae
S
Namikoshi
Michio
M
Ooi
Takashi
T
Kusumi
Takenori
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018942:Macrolides; C526623:aspergillide A; C526625:aspergillide B; C526624:aspergillide C