Morphinane alkaloid dimers from Sinomenium acutum.
Two new morphinane alkaloid dimers, 2,2'-disinomenine (1) and 7',8'-dihydro-1,1'-disinomenine (2), and known 1, 1'-disinomenine (3), were isolated from ethanol extracts of stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of alkaloids 1-3 was determined by direct comparison of their CD spectra with the known alkaloid sinomenine. The isolated alkaloids were tested for cytotoxicity against A549, P388, and HeLa cell lines, and 1 and 3 showed weak inhibition against A549 and Hela cells.
Jin
Hui-Zi
HZ
Shanghai Institute of Materia Medical, Chinese Academy of Sciences, People's Republic of China.
Wang
Xiao-Ling
XL
Wang
Hong-Bing
HB
Wang
Yu-Bo
YB
Lin
Li-Ping
LP
Ding
Jian
J
Qin
Guo-Wei
GW
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032841:Sinomenium / Q000737:chemistry*
C527625:2,2'-disinomenine; C527626:7',8'-dihydro-1,1'-disinomenine; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D009019:Morphinans; C009271:sinomenine