title: Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population.
abstract: Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America. Our aim was to determine whether these SNPs were associated with MI in a southern Europe/Mediterranean population. We employed a case-control association design involving 416 MI patients and 308 non-MI controls from Italy. Significant allelic association was identified between all four SNPs and MI. The association remained significant after adjusting for covariates for MI (P=0.007-0.029). One risk haplotype (GGGG; P=0.028) and one protective haplotype (AAAA; P=0.047) were identified. Genotypic association analysis demonstrated that the SNPs conferred susceptibility to MI most likely in a dominant model (P=0.0007-0.013). When the case cohort was divided into a group of MI patients with a family history (n=248) and one group without it (n=168), the positive, significant association was identified only in the group with the family history. These results indicate that chromosome 9p21 confers risk for development of MI in an Italian population.
authors: Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
authors: Gong-Qing
authors: GQ
authors: Shen
authors: Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
authors: Shaoqi
authors: S
authors: Rao
authors: Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
authors: Nicola
authors: N
authors: Martinelli
authors: Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
authors: Lin
authors: L
authors: Li
authors: Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
authors: Oliviero
authors: O
authors: Olivieri
authors: Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
authors: Roberto
authors: R
authors: Corrocher
authors: Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors: Kalil G
authors: KG
authors: Abdullah
authors: Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Stanley L
authors: SL
authors: Hazen
authors: Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Jonathan
authors: J
authors: Smith
authors: Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
authors: John
authors: J
authors: Barnard
authors: Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.|Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors: Edward F
authors: EF
authors: Plow
authors: Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy. domenico.girelli@univr.it.
authors: Domenico
authors: D
authors: Girelli
authors: Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. wangq2@ccf.org.|Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA. wangq2@ccf.org.
authors: Qing K
authors: QK
authors: Wang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*