Erdosteine ameliorates lung injury induced by transient aortic occlusion in rats.
The aim of this experimental study was to evaluate the protective effect of erdosteine on lung injury induced by ischaemia-reperfusion (IR) of the lower extremities of rats. Wistar albino rats (n = 21) were divided into three groups. In the IR group (n = 7), the aorta was cross-clamped for two hours, followed by one hour of reperfusion. In the erdosteine group (n = 7), animals were pretreated with erdosteine 100 mg/kg daily via gastric lavage, starting three days before aortic occlusion. In the control group (n 5 7), the lungs were removed and blood samples were taken immediately after sternotomy. No treatment was given in the control and IR groups. After both lungs were removed, biochemical parameters were measured and broncho-alveolar lavage (BAL ) assessment was made. MDA levels and MPO activities in the lung tissue were significantly reduced in the erdosteine group compared to the IR group. BAL assessment revealed decreased neutrophil counts in the erdosteine-treated group. Pretreatment of animals with erdosteine significantly attenuated transient aortic occlusion-induced remote lung injury, characterised by leukocyte accumulation and lipid peroxidation. The results suggest that erdosteine may be beneficial in amelioration of lung injury caused by IR.
Kurtoglu
Tunay
T
Department of Cardiovascular Surgery, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
Sacar
Mustafa
M
Inan
Bilal Kaan
BK
Duver
M Harun
MH
Guler
Adem
A
Ucak
Alper
A
Us
Melih Hulusi
MH
Yilmaz
Ahmet Turan
AT
D000818:Animals; D001011:Aorta / Q000601:surgery*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005100:Expectorants / Q000627:therapeutic use*; D008168:Lung / Q000737:chemistry; D008171:Lung Diseases / Q000517:prevention & control*; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000150:complications*; D013864:Thioglycolates / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
D005100:Expectorants; D013864:Thioglycolates; D013876:Thiophenes; D008315:Malondialdehyde; C048498:erdosteine