title: Is homocysteine toxic in uremia?
abstract: High levels of homocysteine have been implicated as a cardiovascular risk factor in the general population and in patients with chronic renal failure, and particularly patients on hemodialysis. To classify a risk factor as causally related to a certain disease, both strong epidemiologic data and sound basic-science studies establishing a mechanism are needed. Among the latter, the hypomethylation of proteins and DNA, and protein homocysteinylation, have been investigated in uremia, providing for an array of toxic effects in this disease.
authors: First Division of Nephrology, Department of Pediatrics, and Cardiovascular Research Center, School of Medicine, Second University of Naples, Naples, Italy. alessandra.perna@unina2.it
authors: Alessandra F
authors: AF
authors: Perna
authors: Maria Grazia
authors: MG
authors: Luciano
authors: Paola
authors: P
authors: Pulzella
authors: Ersilia
authors: E
authors: Satta
authors: Rosanna
authors: R
authors: Capasso
authors: Cinzia
authors: C
authors: Lombardi
authors: Diego
authors: D
authors: Ingrosso
authors: Natale G
authors: NG
authors: De Santo
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D000992:Antitoxins / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005492:Folic Acid / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000453:epidemiology*; D009203:Myocardial Infarction / Q000453:epidemiology; D012008:Recurrence; D012016:Reference Values; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D014511:Uremia / Q000139:chemically induced*
chemical_list: D000992:Antitoxins; D006710:Homocysteine; D005492:Folic Acid; D000111:Acetylcysteine