title: Veno-occlusive disease in a child with rhabdomyosarcoma after conventional chemotherapy: report of a case and review of the literature.
abstract: Although veno-occlusive disease of the liver is a well-known complication of high-dose chemotherapy and bone marrow transplantation, it has rarely been observed in children who receive conventional chemotherapy. Most cases in the literature consists of children with Wilms tumor. It has been very uncommon in rhabdomyosarcoma patients until recently, although they commonly receive similar anticancer agents. Here the authors report a 2-year-old boy with rhabdomyosarcoma who developed veno-occlusive disease while receiving VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy regimen according to the IRS-IV protocol. The patient gradually recovered during 2 weeks with supportive treatment only.
authors: Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey. rececen@adu.edu.tr
authors: Emre
authors: E
authors: Cecen
authors: Kamer Mutafoglu
authors: KM
authors: Uysal
authors: Aykan
authors: A
authors: Ozguven
authors: Dilek
authors: D
authors: Gunes
authors: Gulersu
authors: G
authors: Irken
authors: Nur
authors: N
authors: Olgun
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D012074:Remission Induction; D012208:Rhabdomyosarcoma / Q000150:complications* / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D009396:Wilms Tumor / Q000150:complications / Q000628:therapy
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide