Study of different copper (I) catalysts for the "click chemistry" approach to carbanucleosides.
We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acetonitrile)copper hexafluorophosphate ([Cu(CH3CN)4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method.
Broggi
Julie
J
Institut de Chimie Organique et Analytique, Université d'Orléans, Orléans, France.
Joubert
Nicolas
N
Aucagne
Vincent
V
Zevaco
Thomas
T
Berteina-Raboin
Sabine
S
Nolan
Steve P
SP
Agrofoglio
Luigi A
LA
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D008872:Microwaves; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
D009705:Nucleosides; D003300:Copper