title: Estimation of benchmark dose as the threshold amount of alcohol consumption for blood pressure in Japanese workers.
abstract: In order to determine the threshold amount of alcohol consumption for blood pressure, we calculated the benchmark dose (BMD) of alcohol consumption and its 95% lower confidence interval (BMDL) in Japanese workers. The subjects consisted of 4,383 males and 387 females in a Japanese steel company. The target variables were systolic, diastolic, and mean arterial pressures. The effects of other potential covariates such as age and body mass index were adjusted by including these covariates in the multiple linear regression models. In male workers, BMD/BMDL for alcohol consumption (g/week) at which the probability of an adverse response was estimated to increase by 5% relative to no alcohol consumption, were 396/315 (systolic blood pressure), 321/265 (diastolic blood pressure), and 326/269 (mean arterial pressures). These values were based on significant regression coefficients of alcohol consumption. In female workers, BMD/BMDL for alcohol consumption based on insignificant regression coefficients were 693/134 (systolic blood pressure), 199/90 (diastolic blood pressure), and 267/77 (mean arterial pressure). Therefore, BMDs/BMDLs in males were more informative than those in females as there was no significant relationship between alcohol and blood pressure in females. The threshold amount of alcohol consumption determined in this study provides valuable information for preventing alcohol-induced hypertension.
authors: Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan. suwa@faculty.chiba-u.jp
authors: Yasushi
authors: Y
authors: Suwazono
authors: Kouichi
authors: K
authors: Sakata
authors: Mitsuhiro
authors: M
authors: Oishi
authors: Yasushi
authors: Y
authors: Okubo
authors: Mirei
authors: M
authors: Dochi
authors: Etsuko
authors: E
authors: Kobayashi
authors: Teruhiko
authors: T
authors: Kido
authors: Koji
authors: K
authors: Nogawa
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012306:Risk; D012727:Sex Characteristics
chemical_list: D000431:Ethanol