Jekyll & Hyde: evolution of a superfamily.
Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase.
Martinis
Susan A
SA
Department of Biochemistry, 419 Roger Adams Laboratory, Box B-4, 600 South Mathews Avenue, University of Illinois-Urbana, Urbana, IL 61801, USA. martinis@uiuc.edu
Joy Pang
Yan Ling
YL
D020816:Amino Acid Motifs; D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics*; D011487:Protein Conformation; D014448:Tyrosine-tRNA Ligase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D016207:Cytokines; D000604:Amino Acyl-tRNA Synthetases; D014448:Tyrosine-tRNA Ligase