title: Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata/Schistosoma mansoni model: new candidates identified by a global comparative proteomics approach.
abstract: The co-evolutionary dynamics that exist in host-parasite interactions sometimes lead to compatibility polymorphisms, the molecular bases of which are rarely investigated. To identify key molecules that are involved in this phenomenon in the Schistosoma mansoni/Biomphalaria glabrata model, we developed a comparative proteomics approach using the larval stages that interact with the invertebrate host. We used qualitative and quantitative analyses to compare the total proteomes of primary sporocysts from compatible and incompatible parasite strains. The differentially expressed proteins thus detected belong to three main functional groups: (i) scavengers of reactive oxygen species, (ii) components of primary metabolism, and (iii) mucin-like proteins. We discuss the putative roles played by these protein families as determinants of compatibility polymorphism. Since mucins are known to play key roles in the host-parasite interplay, we consider the newly discovered S. mansoni mucin-like proteins (SmMucin-like) as the most promising candidates for influencing the fate of host-parasite interactions. An analysis of their expression is presented in a paper published in the same journal issue.
authors: Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS, EPHE, UPVD, Biologie & Ecologie Tropicale et Méditerranéenne, Université de Perpignan, Perpignan Cedex, France.
authors: Emmanuel
authors: E
authors: Roger
authors: Guillaume
authors: G
authors: Mitta
authors: Yves
authors: Y
authors: Moné
authors: Anne
authors: A
authors: Bouchut
authors: Anne
authors: A
authors: Rognon
authors: Christoph
authors: C
authors: Grunau
authors: Jérôme
authors: J
authors: Boissier
authors: André
authors: A
authors: Théron
authors: Benjamin E F
authors: BE
authors: Gourbal
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000469:parasitology*; D002853:Chromatography, Liquid; D006224:Cricetinae; D015180:Electrophoresis, Gel, Two-Dimensional; D004798:Enzymes / Q000235:genetics / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000302:isolation & purification; D006790:Host-Parasite Interactions; D007814:Larva / Q000737:chemistry* / Q000235:genetics; D009077:Mucins / Q000235:genetics / Q000302:isolation & purification; D020543:Proteome / Q000032:analysis*; D012550:Schistosoma mansoni / Q000737:chemistry* / Q000235:genetics; D053719:Tandem Mass Spectrometry
chemical_list: D004798:Enzymes; D016166:Free Radical Scavengers; D009077:Mucins; D020543:Proteome