title: Sclerosing epithelioid fibrosarcoma of the pituitary.
abstract: Primary pituitary sarcoma in the absence of previous radiation therapy is very rare, only eight cases having been reported. We present the first reported case of sclerosing epithelioid fibrosarcoma of the pituitary, a 56-year-old woman presenting with diplopia and panhypopituitarism. Magnetic resonance imaging showed a 1.2 x 0.4 x 0.5-cm sellar mass invading the right cavernous sinus. Despite surgery and radiation therapy, our patient developed intracranial metastases and died 2 years after the initial diagnosis. Sclerosing epithelioid fibrosarcoma is an infrequently occurring, distinct variant of soft tissue fibrosarcoma. Its immunophenotype includes vimentin and occasionally CD-34, B cell lymphoma-2, S-100 protein, or keratin expression. Although initially thought to be a low-grade lesion, sclerosing epithelioid fibrosarcomas may also behave in a high-grade manner.
authors: Fairview Hospital, Cleveland Clinic Health System, 18101 Lorain Avenue, Cleveland, OH 44111, USA.
authors: Anamaria
authors: A
authors: Massier
authors: Bernd W
authors: BW
authors: Scheithauer
authors: Harris C
authors: HC
authors: Taylor
authors: Christopher
authors: C
authors: Clark
authors: Luis
authors: L
authors: Llerena
mesh_terms: D001168:Arthritis / Q000150:complications; D003937:Diagnosis, Differential; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery; D010024:Osteoporosis / Q000150:complications; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D016634:Radiosurgery; D020246:Venous Thrombosis / Q000139:chemically induced