[Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees].
OBJECTIVE
To investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees.


METHODS
Patients and controls with/without familial history were enrolled in the same place.


RESULTS
Carriers with AG or AA genotype from pedigrees had higher disease risk than those with GG genotype (OR=1.98, 95% CI:1.19-3.29,OR=2.46,95% CI:1.39-4.34), the frequency of A allele was higher in the patients from pedigrees than inner controls and patients who had no familial history (P=0.01). The frequency of A allele was higher in the inner controls than outer ones (P=0.001). The insulin resistance index, insulin sensitivity index and pancreatic secretion index of inner controls with AG genotype were higher than those with GG genotype (All P < 0.05).


CONCLUSIONS
This polymorphism of UT-II gene might be a risk to type 2 diabetes, the insulin function of people from pedigrees is associated with the mutation.
Wu
Xue-ji
XJ
Department of Epidemiology and Statistics, Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China.
Qin
Lei
L
Zhou
Jin-yi
JY
Cheng
Jin-luo
JL
Shen
Mo-yu
MY
Wang
Jin-song
JS
Zhou
Ling
L
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic; D014579:Urotensins / Q000235:genetics*
D014579:Urotensins; C029677:urotensin II