[Sequelae of viral lower respiratory tract infections in children].
Viral lower respiratory tract infections in children can lead to long-term complications. Of these, the most studied one is the triggering effect of viral infection on the subsequent development of asthma. A better understanding of the interactions between host genetic factors and virus-specific factors is necessary to determine whether severe viral lower respiratory tract infections can really induce asthma or if it is the predisposition to asthma which induces an increased risk of severe infection in the case of viral infection. Bronchiolitis obliterans, less common though very severe, is another complication. Adenovirus is the leading cause of this complication, leading to persistent and severe obstructive airway diseases. No treatment exists to prevent this adverse progression efficiently enough during the course of severe viral infections.
Delacourt
Christophe
C
Service de pédiatrie, Centre hospitalier intercommunal de Créteil, 94010 Créteil. christophe.delacourt@chicreteil.fr
D001249:Asthma / Q000821:virology; D001989:Bronchiolitis Obliterans / Q000821:virology; D002648:Child; D018450:Disease Progression; D006801:Humans; D012141:Respiratory Tract Infections / Q000150:complications / Q000821:virology*