title: Clinical spectrum of choroidal nevi based on age at presentation in 3422 consecutive eyes.
abstract: OBJECTIVE
  To evaluate the clinical features of choroidal nevi based on patient age at presentation and to investigate features of the nevi that are predictive of patient symptoms.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Three thousand four hundred twenty-two consecutive eyes of 3187 patients.
  
  
  METHODS
  Retrospective clinic-based study of clinical features at referral. Cox proportional hazards regressions were used for evaluation of factors predictive of patient symptoms.
  
  
  METHODS
  Nevus features as related to patient age group at diagnosis (young [< or =20 years], mid-adult [21-50 years], older adult [>50 years]) and factors predictive of patient symptoms secondary to the nevus.
  
  
  RESULTS
  Of the 3422 eyes with choroidal nevus, 63 (2%) were in young patients, 795 (23%) in mid-adults, and 2564 (75%) in older adults. The following factors showed no substantial increase or decrease by age category (young, mid-adult, older adult) at presentation: symptoms (14%, 12%, 13%), mean nevus base (5.6, 4.7, 5.2 mm), intrinsic nevus pigmentation (89%, 74%, 77%), related subretinal fluid (SRF) (11%, 15%, 9%), overlying orange pigment (6%, 10%, 6%), retinal pigment epithelial hyperplasia (0%, 9%, 7%), and retinal pigment epithelial atrophy (2%, 13%, 10%). The following factors statistically increased with age category: multiple nevi per eye (2%, 8%, 10%) (P = 0.0001), mean nevus thickness (1.2, 1.5, 1.6 mm) (P<0.0001), and overlying drusen (11%, 40%, 58%) (P<0.0001). Using multivariate analysis of the entire group, factors predictive of any symptom included nonpigmented nevus (P<0.001), location < or = 3 mm to foveola (P = 0.001), subfoveolar fluid (P = 0.002), any SRF (P = 0.02), and subfoveolar nevus (P = 0.027).
  
  
  CONCLUSIONS
  Choroidal nevi show similar clinical features regardless of age of presentation, with the exception of increasing number of nevi per eye, slightly increasing thickness, and increasing drusen in adults versus younger patients. Symptomatic nevi are more likely to be nonpigmented, beneath the foveola, and with subfoveolar fluid.
authors: Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. carol.shields@shieldsoncology.com
authors: Carol L
authors: CL
authors: Shields
authors: Minoru
authors: M
authors: Furuta
authors: Arman
authors: A
authors: Mashayekhi
authors: Edwina L
authors: EL
authors: Berman
authors: Jonathan D
authors: JD
authors: Zahler
authors: Daniel M
authors: DM
authors: Hoberman
authors: Diep H
authors: DH
authors: Dinh
authors: Jerry A
authors: JA
authors: Shields
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002830:Choroid Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D009887:Ophthalmoscopy; D012189:Retrospective Studies