title: Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus.
abstract: Patients with systemic lupus erythematosus (SLE) have accelerated atherogenesis. A recent study suggested that Chlamydia pneumoniae infection might also be a contributing factor in the development of atherogenesis in patients with SLE. The objective of this study was to investigate the possible association of C. pneumoniae infection with markers of atherosclerosis in adolescents with SLE compared with age-matched healthy controls. History and exam focused on cardiovascular risk factors were obtained from 20 patients with SLE and 20 age- and sex-matched controls. Laboratory studies included serum lipid profile and high-sensitivity C-reactive protein (hsCRP). Detection of C. pneumoniae in peripheral blood mononuclear cells (PBMCs) and in nasopharyngeal swab specimens was performed. Carotid Intima-Media Thickness (CIMT) was determined by sonography in all subjects. C. pneumoniae DNA was not detected in PBMCs of any of the patients or controls. Nasopharyngeal cultures were also negative for C. pneumoniae in all patients. CIMT was slightly higher in the SLE group (0.48 +/- 0.049) compared with controls (0.454 +/- 0.041, p = 0.29). There was no significant difference between the two groups in body mass index, blood pressure, hsCRP, and serum cholesterol (total, LDL and HDL). Serum triglycerides were higher in the lupus group (p = 0.03). Children and adolescents with SLE might have accelerated atherosclerosis; however, we did not observe an association with C. pneumoniae infection in this population.
authors: Division of Allergy and Immunology, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA. corinna@bowser.org
authors: Corinna S
authors: CS
authors: Bowser
authors: Swati
authors: S
authors: Kumar
authors: Louis
authors: L
authors: Salciccioli
authors: Andrei
authors: A
authors: Kutlin
authors: Jason
authors: J
authors: Lazar
authors: Imran
authors: I
authors: Rahim
authors: Amy
authors: A
authors: Suss
authors: Stephan
authors: S
authors: Kohlhoff
authors: Margaret R
authors: MR
authors: Hammerschlag
authors: Hamid Jack
authors: HJ
authors: Moallem
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000209:etiology* / Q000382:microbiology; D002690:Chlamydia Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male
chemical_list: D004269:DNA, Bacterial