title: Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation.
abstract: The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabecular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure-function relationships throughout the trabecular bone structural hierarchy.
authors: Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Adelaide, Australia.
authors: Jonathan
authors: J
authors: Norman
authors: Joe G
authors: JG
authors: Shapter
authors: Ken
authors: K
authors: Short
authors: Lachlan J
authors: LJ
authors: Smith
authors: Nicola L
authors: NL
authors: Fazzalari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D019245:Compressive Strength; D004548:Elasticity; D005269:Femur / Q000502:physiology*; D006244:Hardness; D006245:Hardness Tests; D006801:Humans; D008297:Male; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D036103:Nanotechnology / Q000379:methods*; D013314:Stress, Mechanical; D013718:Tensile Strength