title: A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan.
abstract: A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.
authors: School of Engineering, University of Warwick, Coventry, UK. mjc@eng.warwick.ac.uk
authors: M J
authors: MJ
authors: Chappell
authors: N D
authors: ND
authors: Evans
authors: R J
authors: RJ
authors: Errington
authors: I A
authors: IA
authors: Khan
authors: L
authors: L
authors: Campbell
authors: R
authors: R
authors: Ali
authors: K R
authors: KR
authors: Godfrey
authors: P J
authors: PJ
authors: Smith
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002453:Cell Cycle / Q000187:drug effects* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D019772:Topotecan / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006113:United Kingdom
chemical_list: D000970:Antineoplastic Agents; D019772:Topotecan