[Bone lesion in multiple myeloma].
Bone destruction is a hallmark of multiple myeloma(MM). Almost all MM patients develop osteolytic bone lesions that can cause pathologic fractures and severe bone pain. Osteolytic lesions result from increased bone resorption due to osteoclast stimulation and decreased bone formation due to osteoblast inhibition. Plain radiography, CT, and MRI are established imaging techniques in MM. FDG-PET imaging is promising newer scanning technique under current evaluation. The aggressive features of MM bone lesions have significantly contributed to poor prognosis. Therefore, a systemic approach to analgesia, which includes radiotherapy and orthopedic intervention, must be applied as a part of the comprehensive care plan of MM patient. Bisphosphonates have been shown to reduce vertebral fractures and bone pain.
Ise
Mikiko
M
Division of Hematology-Oncology, Chiba Cancer Center.
Takagi
Toshiyuki
T
D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D004164:Diphosphonates / Q000008:administration & dosage; D050723:Fractures, Bone / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications*; D010146:Pain / Q000209:etiology; D059408:Pain Management; D011878:Radiotherapy; D011879:Radiotherapy Dosage; D054854:Vertebroplasty
D050071:Bone Density Conservation Agents; D004164:Diphosphonates