title: [Oral anticoagulation and the risk of major bleeding].
abstract: Oral anticoagulants are frequently used in clinical practice. The most important complication of oral anticoagulation is major bleeding. The incidence of major bleeding is about 2-3%/year in randomized controlled trials but may be considerably higher under real life conditions. Major bleeding risk in patients receiving oral anticoagulants depends on factors related to anticoagulation itself (intensity and quality), patient-related factors (demographic characteristics and comorbid diseases), and concomitant treatments with antiplatelet or non-steroidal anti-inflammatory drugs. The role of clinical prediction rules for major bleeding is discussed.
authors: Service de médecine interne BH10-622, CHUV, 1011 Lausanne monica.cosma@chuv.ch
authors: Monica
authors: M
authors: Cosma Rochat
authors: Gérard
authors: G
authors: Waeber
authors: Olivier
authors: O
authors: Lamy
authors: Drahomir
authors: D
authors: Aujesky
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006470:Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D012307:Risk Factors
chemical_list: D000925:Anticoagulants