Brain abscess caused by Streptomyces infection following penetration trauma: case report and results of susceptibility analysis of 92 isolates of Streptomyces species submitted to the CDC from 2000 to 2004.
The case of a patient who presented with a brain abscess caused by Streptomyces infection following penetrating cerebral trauma with a soil-contaminated object generated an interest in optimizing antimicrobial therapy. Collaboration with the Centers for Disease Control and Prevention led to the analysis of susceptibility data for Streptomyces isolates that suggested that amikacin (100% susceptibility for 92 isolates tested) and linezolid, an oxazolidinone (100% susceptibility for 41 isolates tested), offer reliable activity against all isolates.
Rose
Charles E
CE
Department of Medicine, Medical College of Georgia, BA 5300, 15th Street, Augusta, GA 30912, USA. crose@mcg.edu
Brown
June M
JM
Fisher
John F
JF
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001922:Brain Abscess / Q000382:microbiology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000187:drug effects* / Q000302:isolation & purification*; D014950:Wounds, Penetrating / Q000150:complications*
D000900:Anti-Bacterial Agents