title: Bone regenerated via rhPDGF-bB and a deproteinized bovine bone matrix: backscattered electron microscopic element analysis.
abstract: This study used backscattered electron microscopy (BSE-SEM) to analyze specimens in which bone was augmented both horizontally and vertically with a xenograft scaffold and recombinant human platelet-derived growth factor (rhPDGF-BB), with or without a resorbable collagen membrane. The study objective was to compare percentage weight and volume calcium-phosphorus ratios of regenerated bone and native bone and the nature of the bony contact with two different implant surfaces. Examination of the nature of the mineralized tissues by BSE-SEM provides an understanding of the composition and element ratio of bone regenerated from nonautogenous grafts. The data collected demonstrated no statistically significant difference between regenerated bone and native bone in the two tested groups. Our observations suggest that bone regenerated via nonautogenous grafts displays composition, structure, and physical properties very similar to those of native bone. Similarly, no significant differences were observed at the bone-implant interface between bone regenerated proximal to oxidized versus machined implants.
authors: Department of Periodontology, School of Dentistry, University of Milan, Italy. isabella.rocchietta@gmail.com
authors: Isabella
authors: I
authors: Rocchietta
authors: Claudia
authors: C
authors: Dellavia
authors: Myron
authors: M
authors: Nevins
authors: Massimo
authors: M
authors: Simion
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D000077214:Becaplermin; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000187:drug effects*; D002118:Calcium / Q000032:analysis; D002417:Cattle; D004285:Dogs; D004337:Drug Carriers; D004577:Electron Probe Microanalysis; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D010758:Phosphorus / Q000032:analysis; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D010758:Phosphorus; D002118:Calcium