[Molecular mechanisms inhibiting proliferation of myeloma cells].
Accumulating evidences suggest that many molecules are working as inhibitors of proliferation in myeloma cells e.g., PTEN, mTOR(PI3-kinase signal molecules), p53, RB1, INK4 family and KIP/CIP family (cell cycle check point molecules), PF4 (inhibitor of angiogenesis). In this review, significance of these molecules in myeloma is summarized. Additionally, our finding of growth inhibitory effect by PU.1 is explained.
Kikukawa
Yoshitaka
Y
Department of Hematology, Kumamoto University Hospital.
Okuno
Yutaka
Y
Hata
Hiroyuki
H
D002455:Cell Division / Q000235:genetics*; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000502:physiology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000502:physiology; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology*; D051059:PTEN Phosphohydrolase / Q000502:physiology; D010950:Plasma Cells / Q000166:cytology* / Q000473:pathology; D010978:Platelet Factor 4 / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D058570:TOR Serine-Threonine Kinases; D015534:Trans-Activators / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D000099232:Proto-Oncogene Protein Spi-1
D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051059:PTEN Phosphohydrolase; D010978:Platelet Factor 4; D011494:Protein Kinases; D011518:Proto-Oncogene Proteins; D058570:TOR Serine-Threonine Kinases; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53; D000099232:Proto-Oncogene Protein Spi-1; C546842:MTOR protein, human; C494929:PTEN protein, human