Interactive effect of paraoxonase-1 Q192R polymorphism and smoking history on the lung function decline in grain workers.
OBJECTIVE
This retrospective longitudinal study investigated the association between the Q192R polymorphism of the high-density lipoprotein-associated multifunctional antioxidant enzyme, paraoxonase-1 (PON1), and lung function decline, while taking into account smoking history.


METHODS
The demographic, occupational, and respiratory symptom information and lung function variables were obtained from 216 male Saskatchewan grain workers.


RESULTS
An interaction between the PON1 genotypes and smoking status was observed. Current smokers with the 192R allele had a lower forced expiratory volume in the first second (FEV(1)) and FEV(1) per forced vital capacity (FVC). The annual decline rate of FEV(1)/FVC in current smokers was greater among 192R allele carriers than noncarriers (0.58+/-0.05 vs. 0.35+/-0.04 %/yr, p<0.0001). A similar result was observed with FEV(1) (40.9+/-6.4 vs. -33.0+/-7.0 mL/yr, p=0.10). The annual decline rate of FVC was not influenced by the genotypes.


CONCLUSIONS
These results strengthened the previous findings of our cross-sectional study, suggesting that the 192R allele may be a novel genetic risk factor for airway injury among current smokers.
Seo
Takayuki
T
Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
Pahwa
Punam
P
McDuffie
Helen H
HH
Nakada
Naoyuki
N
Goto
Shuji
S
Ghosh
Sunita
S
Nakagawa
Kazuko
K
D000328:Adult; D000383:Agriculture; D043303:Aryldialkylphosphatase / Q000235:genetics*; D002523:Edible Grain; D005541:Forced Expiratory Volume; D005973:Glutamine; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012525:Saskatchewan; D012907:Smoking / Q000453:epidemiology* / Q000235:genetics; D014481:United States / Q000453:epidemiology
D005973:Glutamine; D043303:Aryldialkylphosphatase