Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis.
We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
Tesse
Riccardina
R
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy. Electronic address: nucciatesse@hotmail.com.
Cardinale
Fabio
F
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Santostasi
Teresa
T
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Polizzi
Angela
A
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Mappa
Luigi
L
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Manca
Antonio
A
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
De Robertis
Francesco
F
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Silecchia
Ombretta
O
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
Armenio
Lucio
L
Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011552:Pseudomonas Infections / Q000235:genetics / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000302:isolation & purification*; D055815:Young Adult
D016753:Interleukin-10