The Arabidopsis circadian clock incorporates a cADPR-based feedback loop.
Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
Dodd
Antony N
AN
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
Gardner
Michael J
MJ
Hotta
Carlos T
CT
Hubbard
Katharine E
KE
Dalchau
Neil
N
Love
John
J
Assie
Jean-Maurice
JM
Robertson
Fiona C
FC
Jakobsen
Mia Kyed
MK
Gonçalves
Jorge
J
Sanders
Dale
D
Webb
Alex A R
AA
D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D002940:Circadian Rhythm / Q000235:genetics; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D025461:Feedback, Physiological; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D009536:Niacinamide / Q000494:pharmacology; D018515:Plant Leaves / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
D036563:Cyclic ADP-Ribose; D009536:Niacinamide; D002118:Calcium