The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.
Focal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying aetiology of FCD remains uncertain and research has been hampered by the lack of a good animal model in which to simulate the condition. In this article we review some of the potential molecular mechanisms that might underpin human FCD. In particular we examine the potential role of cyclin-dependent kinase 5 and its principal activator p35 in FCD and estimate the contribution that deregulation of cyclin-dependent kinase 5 might make to the pathogenesis of this condition.
Sen
Arjune
A
Department of Clinical and Experimental Epilepsy, University College London, London, UK. a.sen@ion.ucl.ac.uk
Thom
Maria
M
Nikolić
Margareta
M
Sisodiya
Sanjay M
SM
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000201:enzymology* / Q000503:physiopathology; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation / Q000235:genetics; D004827:Epilepsy / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D054220:Malformations of Cortical Development / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; C500695:CDCA5 protein, human; D018797:Cell Cycle Proteins; D051360:Cyclin-Dependent Kinase 5