[Meningiomas: anatomical pathology and molecular biology].
In the past 5-10 years, there has been a considerable progress the understanding of the biology of meningioma. The most important advances have been made by comprehensive studies of the pathogenesis of meningioma in molecular genetics. Several target genes could be identified for mutation or inactivation. Additional chromosomal regions that are usually subject to deletion or amplification and point to the presence of tumor suppressor genes or proto-oncogenes were found. The revised and updated 2000 WHO Classification is a major innovation in the histopathology of meningiomas. The new classification system more precisely and objectively determines the grade of meningioma, which allows one to more logically make a prognosis of the recurrence and aggressive behavior of the tumor. The present overview places particular emphasis on recent advances in its molecular biology. It summarizes the most important aspects of the classification of meningiomas, which makes it possible to include the results of biological observations into the respective context, and also considers the mechanisms of angiogenesis and edema development and the role of hormonal receptors in meningiomas.
Bekiashev
A Kh
AKh
Korshunov
A G
AG
Cherekaev
V A
VA
D002877:Chromosomes, Human / Q000235:genetics* / Q000378:metabolism; D004487:Edema / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016147:Genes, Tumor Suppressor; D006801:Humans; D008579:Meningioma / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009154:Mutation; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D011519:Proto-Oncogenes; D014944:World Health Organization