title: The clinical impact and incidence of periocular pigmentation associated with either latanoprost or bimatoprost therapy.
abstract: OBJECTIVE
  To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost.
  
  
  METHODS
  A retrospective, active-controlled comparison of consecutive patients treated with latanoprost or bimatoprost for 12 months evaluating patients to determine the incidence, characteristics, and reversibility of periocular pigmentation.
  
  
  RESULTS
  Periocular pigmentation was found in 1% patients treated with latanoprost and 6% patients treated with bimatoprost within 12 months of beginning treatment (p = 0.004).
  
  
  CONCLUSIONS
  This study suggests that periocular pigmentation may develop after treatment with latanoprost or bimatoprost.
authors: Glaucoma Consultants and Center For Eye Research, Mount Pleasant, South Carolina, USA.
authors: Elizabeth D
authors: ED
authors: Sharpe
authors: Adam C
authors: AC
authors: Reynolds
authors: Gregory L
authors: GL
authors: Skuta
authors: Jessica N
authors: JN
authors: Jenkins
authors: William C
authors: WC
authors: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D000577:Amides / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D000069580:Bimatoprost; D003008:Cloprostenol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005127:Eye Color / Q000187:drug effects; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008055:Lipids / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000503:physiopathology; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*; D012189:Retrospective Studies; D012880:Skin Pigmentation / Q000187:drug effects*; D014065:Tonometry, Ocular
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D008055:Lipids; D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D000077338:Latanoprost; D000069580:Bimatoprost