title: Dectin-1 Fc targeting of aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis.
abstract: Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
authors: Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors: Polly E
authors: PE
authors: Mattila
authors: Allison E
authors: AE
authors: Metz
authors: Rekha R
authors: RR
authors: Rapaka
authors: Lynne D
authors: LD
authors: Bauer
authors: Chad
authors: C
authors: Steele
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D001232:Aspergillus fumigatus / Q000276:immunology* / Q000378:metabolism; D007113:Immunity, Innate; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D037181:Lectins, C-Type; D008172:Lung Diseases, Fungal / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D016676:Macrophages, Alveolar / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D047071:beta-Glucans / Q000276:immunology*; D000099181:Dectin-1
chemical_list: D007141:Immunoglobulin Fc Fragments; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D047071:beta-Glucans; D000099181:Dectin-1