[Genotype analysis of CYP1A2 IVS4 + 43A/G in patients with prostate cancer].
OBJECTIVE
To investigate the genotype of the single nucleotide polymorphisms(SNP) of CYP1A2 IVS4 + 43A/G in patients with prostate cancer by TaqMan allelic discrimination.


METHODS
TaqMan SNP allelic discrimination was performed with the ABI 7300 system to detect the genotype of CYP1A2 IVS4 + 43A/G in 85 patients with prostate cancer.


RESULTS
The genotypes of CYP1A2 IVS4 + 43A/G in the patients were as follows: AA subtype in 5 cases (5.9%), AG in 33 (38.8%), and GG in 47 (55.3%). Each subtype of CYP1A2 IVS4 + 43A/G was not correlated with the Gleason score of prostate cancer.


CONCLUSIONS
There was no significant correlation between SNP of CYP1A2 and the differentiation of prostate cancer.
Ge
Jing-ping
JP
Department of Urology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Wei
Wu
W
Shang
Xue-jun
XJ
Zhang
Zheng-yu
ZY
Xu
Song
S
Wang
Dong
D
Gao
Jian-ping
JP
D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
D019388:Cytochrome P-450 CYP1A2