title: Malignant hyperthermia in a liver transplant patient: a case report.
abstract: Malignant hyperthermia is an autosomal dominant disorder with incomplete penetrance and variable expression. This syndrome is characterized by a hypermetabolic response to all commonly used inhalational anesthetics and depolarizing muscle relaxants. It can happen during or after the anesthesia. We describe a case of malignant hyperthermia during orthotopic liver transplantation. Our patient was a 48-year-old man, born in Brazil but with European ascendance, who developed malignant hyperthermia associated with the use of isoflurane. He was treated with dantrolene, which caused hepatic graft dysfunction. It is important that transplant teams be able to recognize and treat this complication.
authors: Surgery Department, Federal University of Ceará, Ceará, Brazil. crf@fortalnet.com.br
authors: C R
authors: CR
authors: Fernandes
authors: D M
authors: DM
authors: Azevedo
authors: J M
authors: JM
authors: Gomes
authors: B P
authors: BP
authors: Gonçalves
authors: G R
authors: GR
authors: Coelho
authors: J B
authors: JB
authors: Vasconcelos
authors: J H
authors: JH
authors: Garcia
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects; D001663:Bilirubin / Q000097:blood; D003620:Dantrolene / Q000627:therapeutic use*; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced / Q000188:drug therapy*; D007530:Isoflurane / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D009125:Muscle Relaxants, Central; D007530:Isoflurane; D003620:Dantrolene; D001663:Bilirubin