title: Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia.
abstract: OBJECTIVE
  To compare a strategy of combination therapy with a strategy of monotherapy with broad-spectrum antibiotics for suspected late ventilator-associated pneumonia.
  
  
  METHODS
  Randomized trial.
  
  
  METHODS
  Twenty-eight intensive care units in Canada and the United States.
  
  
  METHODS
  The study included 740 mechanically ventilated patients who developed suspected ventilator-associated pneumonia after 96 hrs in the intensive care unit. Patients known to be colonized or infected with Pseudomonas or methicillin-resistant Staphylococcus aureus or who were immunocompromised were excluded from the study.
  
  
  METHODS
  As initial unblinded therapy, patients were allocated to receive meropenem (1 g every 8 hrs) and ciprofloxacin (400 mg every 12 hrs) or meropenem alone. Before starting antibiotics, patients were also randomized to bronchoalveolar lavage with quantitative cultures or endotracheal aspirates. When culture results were available, physicians were encouraged to adjust antibiotics. Adequacy of antibiotics was defined as the organism present in the enrollment culture having in vitro susceptibility to one or more of the study antibiotics.
  
  
  RESULTS
  Baseline characteristics and etiologies of ventilator-associated pneumonia were similar in the two groups. There was no difference in 28-day mortality between the combination and monotherapy groups (relative risk = 1.05, 95% confidence interval 0.78-1.42, p = .74). Duration of intensive care unit and hospital stay, clinical and microbiological treatment response, emergence of antibiotic-resistant bacteria, isolation of Clostridium difficile in stool, and fungal colonization were also similar in the two groups. In a subgroup of patients who had infection due to Pseudomonas species, Acinetobacter species, and multidrug-resistant gram-negative bacilli at enrollment (n = 56), the adequacy of initial antibiotics (84.2% vs. 18.8%, p < .001) and microbiological eradication of infecting organisms (64.1% vs. 29.4%, p = .05) was higher in the combination group compared with the monotherapy group, but there were no differences in clinical outcomes.
  
  
  CONCLUSIONS
  For critically ill patients who have suspected late ventilator-associated pneumonia and who are at low risk for difficult-to-treat gram-negative bacteria, monotherapy is associated with similar outcomes compared with combination therapy. For those patients at high risk of difficult-to-treat gram-negative bacteria, combination therapy is safe and may be associated with better microbiological and clinical outcomes.
authors: Kingston General Hospital and Queen's University, Kingston, ON, Canada. dkh2@queensu.ca
authors: Daren K
authors: DK
authors: Heyland
authors: Peter
authors: P
authors: Dodek
authors: John
authors: J
authors: Muscedere
authors: Andrew
authors: A
authors: Day
authors: Deborah
authors: D
authors: Cook
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy*; D013845:Thienamycins / Q000008:administration & dosage*
chemical_list: D000890:Anti-Infective Agents; D013845:Thienamycins; D002939:Ciprofloxacin; D000077731:Meropenem