Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats.
Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
Chandrasekaran
Victor Raj Mohan
VR
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Wan
Chang-Hsin
CH
Liu
Li-Lian
LL
Hsu
Dur-Zong
DZ
Liu
Ming-Yie
MY
D000082:Acetaminophen / Q000633:toxicity*; D000208:Acute Disease; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005978:Glutathione / Q000378:metabolism; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000008:administration & dosage* / Q000627:therapeutic use; D031685:Sesamum; D013481:Superoxides / Q000037:antagonists & inhibitors
D018712:Analgesics, Non-Narcotic; D013481:Superoxides; D017665:Hydroxyl Radical; D000082:Acetaminophen; D012715:Sesame Oil; D005978:Glutathione