Scoring radiologic characteristics to predict proliferative potential in meningiomas.
We investigated the feasibility of using radiologic characteristics to predict the proliferative potential in meningiomas. Our statistical analysis revealed that the presence of peritumoral edema, an ambiguous brain-tumor border, and irregular tumor shape were significantly correlated with a higher MIB-1 staining index (SI) value. We developed the following scoring system for specific features in each tumor: peritumoral edema (tumor with edema = 1, tumor without edema = 0); brain-tumor border (tumor with any ambiguous border = 1, tumor circumscribed by a distinct rim = 0); and tumor shape (tumor with irregular shape = 1, tumor with smooth shape = 0). Using Spearman's correlation coefficient analysis, we found a significant correlation (P < 0.005) between total score calculated for each patient and SI value. Our findings suggest that the proliferative potential of meningiomas can be predicted using a less invasive preoperative examination focusing on the presence of peritumoral edema, ambiguous brain-tumor border, and irregular tumor shape.
Hashiba
Tetsuo
T
Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hashimoto
Naoya
N
Maruno
Motohiko
M
Izumoto
Shuichi
S
Suzuki
Tsuyoshi
T
Kagawa
Naoki
N
Yoshimine
Toshiki
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001929:Brain Edema / Q000473:pathology; D049109:Cell Proliferation; D048430:Cell Shape / Q000502:physiology; D004396:Coloring Agents; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000473:pathology* / Q000532:radiotherapy*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000378:metabolism; D055815:Young Adult
D014408:Biomarkers, Tumor; D004396:Coloring Agents; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C077171:HIVEP2 protein, human; D005682:Gadolinium