title: Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
abstract: A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype 1a assays.
authors: Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. todd.bosse@abbott.com
authors: Todd D
authors: TD
authors: Bosse
authors: Daniel P
authors: DP
authors: Larson
authors: Rolf
authors: R
authors: Wagner
authors: Doug K
authors: DK
authors: Hutchinson
authors: Todd W
authors: TW
authors: Rockway
authors: Warren M
authors: WM
authors: Kati
authors: Yaya
authors: Y
authors: Liu
authors: Sherie
authors: S
authors: Masse
authors: Tim
authors: T
authors: Middleton
authors: Hongmei
authors: H
authors: Mo
authors: Debra
authors: D
authors: Montgomery
authors: Wen
authors: W
authors: Jiang
authors: Gennadiy
authors: G
authors: Koev
authors: Dale J
authors: DJ
authors: Kempf
authors: Akhter
authors: A
authors: Molla
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005838:Genotype; D016174:Hepacivirus / Q000201:enzymology* / Q000235:genetics; D009281:Naphthalenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D009281:Naphthalenes; D012321:DNA-Directed RNA Polymerases