Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457.
Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457 is reported. Construction of the tetrasaccharide as its 4-methoxyphenyl glycoside was achieved by condensation of less abundant monosaccharide units such as, D-galactofuranose, N-acetyl-D-galactosamine and N-acetylneuraminic acid. The synthetic strategy consists of the preparation of suitably protected required monosaccharide intermediates from the commercially available reducing sugars and high yielding glycosylation reactions.
Kumar
Rishi
R
Medicinal and Process Chemistry Division and Molecular and Structural Biology Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001 Uttar Pradesh, India.
Maulik
Prakas R
PR
Misra
Anup Kumar
AK
D002240:Carbohydrate Sequence; D020611:Hafnia alvei / Q000737:chemistry* / Q000276:immunology; D015394:Molecular Structure; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
D019081:O Antigens; D009844:Oligosaccharides