title: Effects of salicylhydroxamic acid on the proliferation of Atriplex and murine neuroblastoma cells, and on Drosophila egg laying and development.
abstract: Salicylhydroxamic acid (SHAM) inhibits the proliferation of cultured plant (Atriplex halimus) and murine neuroblastoma cells with IC50 of 90 and 250 microM, respectively. After 2 h of application, SHAM induces an acceleration of the neuroblastoma cell cycle from G1/S to G2 phases and, after 6 h, it induces an accumulation of the cells in S phase and a cell swelling. Up to 300 microM, SHAM is not cytotoxic and does not induce electrophysiological differentiation of neuroblastoma cells. When Drosophila females are grown in media containing 0.6-1.25 mM SHAM, the rate and number of laid eggs are increased. Furthermore, SHAM stimulates the different development stages from embryo to adult. A general interpretation of the effects of SHAM on cell proliferation and differentiation is proposed.
authors: Laboratoire d'écotechnologie, université Paris-Sud, 1, allée Cérès, 91440 Bures-sur-Yvette, France. pierre.dutuit@u-psud.fr
authors: Pierre
authors: P
authors: Dutuit
authors: Béatrice
authors: B
authors: Rouzaire-Dubois
authors: Amel
authors: A
authors: Talamali
authors: Bernadette
authors: B
authors: Limbourg-Bouchon
authors: Michel C
authors: MC
authors: Hours
authors: Jean-Marc
authors: JM
authors: Dubois
mesh_terms: D000818:Animals; D027466:Atriplex / Q000166:cytology* / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004330:Drosophila / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology*; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D010057:Oviducts / Q000166:cytology / Q000187:drug effects; D010058:Oviposition / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology*
chemical_list: D012457:Salicylamides; C005703:salicylhydroxamic acid