Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters.
Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of alpha,beta-unsaturated carbonyl compounds and imines have been discovered. These topics will be the focus of this Account.
Ouellet
Stéphane G
SG
Merck Frosst Center for Therapeutic Research, 16711 Trans Canada Highway, Kirkland H9H 3L1, Canada.
Walji
Abbas M
AM
MacMillan
David W C
DW
D000586:Amination; D002384:Catalysis; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
D007097:Imines; D009930:Organic Chemicals