title: Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity.
abstract: OBJECTIVE
  In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. The aim was to assess the relationship of plasma palmitoleic acid content, a product of SCD activity, with triglyceridemia and abdominal adiposity in humans.
  
  
  METHODS
  We evaluated 134 healthy men. Plasma palmitoleic acid content was used as an indirect measurement of SCD activity because that enzyme catalyzes the desaturation from saturated to monounsaturated fatty acids and palmitoleic acid intake is very small.
  
  
  RESULTS
  Subjects with triglycerides > or =75th percentile had a higher palmitoleic acid content than those with triglycerides <75th percentile (3.8+/-0.8 vs 2.8+/-0.9%, p<0.0001). Triglyceridemia was strongly correlated with palmitoleic acid content (PAC) (r=0.533, p<0.001). Mean triglyceridemia was 114% higher (1.43+/-0.75 vs 0.67+/-0.22 mmol/l) in the fourth quartile than in the first quartile of palmitoleic acid content. In a stepwise logistic regression analysis, palmitoleic acid content was the most strongly and independently associated parameter with triglyceridemia, and also with waist circumference when triglyceridemia was not included in the analysis.
  
  
  CONCLUSIONS
  Plasma palmitoleic acid content, a product of SCD activity, is an independent marker of triglyceridemia and abdominal adiposity in men. This enzyme (SCD) could represent a target for prevention and treatment of these metabolic disorders in particular in subjects at risk of developing a metabolic syndrome.
authors: Cardiovascular Prevention Center, Departement de Cardiologie, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes, France. francois.paillard@chu-rennes.fr
authors: François
authors: F
authors: Paillard
authors: Daniel
authors: D
authors: Catheline
authors: Franck Le
authors: FL
authors: Duff
authors: Monique
authors: M
authors: Bouriel
authors: Yves
authors: Y
authors: Deugnier
authors: Michel
authors: M
authors: Pouchard
authors: Jean-Claude
authors: JC
authors: Daubert
authors: Philippe
authors: P
authors: Legrand
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000201:enzymology; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D005229:Fatty Acids, Monounsaturated; D014280:Triglycerides; C008757:palmitoleic acid; D002784:Cholesterol; D013230:Stearoyl-CoA Desaturase