title: Male anorgasmia treated with oxytocin.
abstract: Introduction. This is a case report on male anorgasmia that was successfully treated with oxytocin. Oxytocin is increased during arousal and peaks during orgasm. More recently, a study on humans published in Nature has shown its value in social bonding, increasing trust, and enhancing the sense of well-being. Aim. To test the effectiveness of administering oxytocin in a case of treatment-resistant anorgasmia. Methods. The patient underwent a biopsychosocial evaluation by a psychiatrist trained in sexual medicine and sex therapy for male orgasmic disorder, acquired type. Medical conditions, effect of substances, and psychological issues were ruled out. The patient was properly consented to using oxytocin as an off-label trial. Oxytocin was administered using a nasal spray intracoitally because of its ultra-short half-life. Results. Oxytocin was effective in restoring ejaculation. Conclusions. A case of treatment-resistant male anorgasmia was successfully treated with intracoital administration of intranasal oxytocin.
authors: Cedars-Sinai Medical Center-Psychiatry, Los Angeles, CA, USA;; University of California at Los Angeles (UCLA)-Psychiatry, Los Angeles, CA, USA;. Electronic address: waguih.ishak@cshs.org.
authors: Waguih William
authors: WW
authors: IsHak
authors: Cedars-Sinai Medical Center-Cardiology, Los Angeles, CA, USA.
authors: Daniel S
authors: DS
authors: Berman
authors: Endocrinology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
authors: Anne
authors: A
authors: Peters
mesh_terms: D000368:Aged; D004542:Ejaculation / Q000187:drug effects*; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009948:Orgasm / Q000187:drug effects; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D010120:Oxytocics; D010121:Oxytocin