Electroconvulsive therapy and antibiotics: a case report.
Infections are common comorbid conditions in hospitalized patients, including those receiving electroconvulsive therapy (ECT). In this report, we demonstrate the fluoroquinolone class of antibiotics can be associated with prolonged electroconvulsive seizure duration. We describe an 82-year-old woman treated with the fluoroquinolone, moxifloxacin, during a course of ECT. After previously tolerating ECT well, introduction of moxifloxacin for a respiratory tract infection was associated with prolonged seizure duration despite complete resolution of her respiratory complaint. Taken together with other evidence that fluoroquinolones lower seizure threshold, this report suggests fluoroquinolones should be avoided in patients receiving ECT.
Reti
Irving M
IM
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. imreti@jhmi.edu
Davydow
Dimitry S
DS
D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001372:Aza Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D000077266:Moxifloxacin; D011804:Quinolines / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D019233:Retreatment
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin