title: Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice.
abstract: Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Sargassum fulvellum and Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4 mg/ear) of Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4 mg/ear) of Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5 g/kg bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.
authors: Department of Biotechnology, Pukyong National University, Namku, Busan 608-737, Republic of Korea.
authors: J Y
authors: JY
authors: Kang
authors: M N A
authors: MN
authors: Khan
authors: N H
authors: NH
authors: Park
authors: J Y
authors: JY
authors: Cho
authors: M C
authors: MC
authors: Lee
authors: H
authors: H
authors: Fujii
authors: Y K
authors: YK
authors: Hong
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D044647:Sargassum / Q000737:chemistry; D012624:Seaweed / Q000737:chemistry
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents