title: Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication.
abstract: The role of prolactin (PRL) in the CNS remains uncertain. We evaluated the presence of hyperprolactinemia, intracellular prolactin (ICP), and prolactin receptor (PRL-R) in primary CNS tumors, and their relationship with cellular replication with a prospective cross-sectional study of 82 consecutive patients with primary CNS tumors admitted for neurosurgical resection between October 2003 and September 2005. Patients submitted to a questionnaire, and venous blood samples were obtained for measurement of serum PRL and TSH. Immunohistochemical analyses were performed to evaluate the presence of ICP, PRL-R, and Ki-67. Serum PRL levels ranged from 2 to 70 ng/ml, and hyperprolactinemia was detected in 25 cases (30.5%). ICP was detected in 18 patients (21.9%), in whom PRL ranged from 2 to 32 ng/ml. A positive correlation was found between PRL levels and the presence of ICP (Student's t test, P = 0.022). The PRL-R was observed immunohistochemically in 32 cases (39%). The frequencies of hyperprolactinemia, ICP, and PRL-R were similar across the several histological types of CNS tumors. Ki-67 index was similar in all groups. Hyperprolactinemia and intracellular presence of PRL and PRL-R were common findings in this population, suggesting a role for PRL in CNS tumor genesis.
authors: Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology - Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil.
authors: Carolina Garcia
authors: CG
authors: Soares Leães
authors: Arthur Pereira
authors: AP
authors: Filho
authors: Júlia F S
authors: JF
authors: Pereira Lima
authors: Cristina Micheletto
authors: CM
authors: Dallago
authors: Rafael Loch
authors: RL
authors: Batista
authors: Lígia M
authors: LM
authors: Barbosa-Coutinho
authors: Nelson Pires
authors: NP
authors: Ferreira
authors: Miriam
authors: M
authors: da Costa Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000378:metabolism*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications*; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism*; D011981:Receptors, Prolactin / Q000096:biosynthesis*; D013972:Thyrotropin / Q000097:blood
chemical_list: D019394:Ki-67 Antigen; D011981:Receptors, Prolactin; D011388:Prolactin; D013972:Thyrotropin