Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion.
Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.
Miyake
Katsuhisa
K
Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Moriyama
Masafumi
M
Aizawa
Kumiko
K
Nagano
Shuji
S
Inoue
Yasushi
Y
Sadanaga
Atsushi
A
Nakashima
Hitoshi
H
Nakamura
Seiji
S
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications* / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008882:Mikulicz' Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D010996:Pleural Effusion / Q000150:complications* / Q000166:cytology; D011239:Prednisolone / Q000627:therapeutic use; D018417:Th1 Cells; D018418:Th2 Cells
D000893:Anti-Inflammatory Agents; D011239:Prednisolone