Interstitial pneumonitis associated with sirolimus in liver transplantation: a case report.
Sirolimus is a powerful immunosuppressive drug initially used in kidney transplant patients but now increasingly employed in recipients of other types of solid organ transplants, such as liver, heart, lung, or pancreas. Sirolimus is indicated for rescue therapy and to reduce the toxic side effects of calcineurin inhibitors. However, its use has been associated with an uncommon but important pulmonary toxicity. Reports have described interstitial pneumonitis, bronchiolitis obliterans, organizing pneumonia, and alveolar proteinosis. We present the case of a liver transplant patient with interstitial pneumonitis associated with sirolimus.
Pérez
M J
MJ
Unidad de Hepatologia-Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Carlos Haya, Malaga, Spain. miguel.jimenez.sspa@juntadeandalucia.es
Martín
R O
RO
García
D M
DM
Rey
J M Lozano
JM
de la Cruz Lombardo
J
J
Rodrigo López
J M
JM
D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D020123:Sirolimus