Thirty-two novel HLA-A alleles identified during intermediate resolution testing.
Thirty-two novel human leukocyte antigen-A alleles are described: four A*01 (*0110, *0112, *0113 and *0117), four A*02 (*0263, *0280, *0292 and *9201), two A*03 (*0316 and *0325), four A*11 (*111502, *1117, *1122 and *1123), five A*24 (*2441, *2450, *2455, *2456 and *2457), one A*26 (*2627), two A*29 (*2909 and *2914), two A*30 (*3013 and *3016), one A*32 (A*3213), two A*34 (*3407 and *3408) and five A*68 (*6828, *6829, *6830, *6831 and *6834). Seventeen of the variants are single-nucleotide substitutions from their most homologous allele, which results in amino acid changes (A*0117, *0263, *0292, *0316, *0325, *1122, *1123, *2455, *2456, *2457, *2627, *2909, *3016, *3407, *6828, *6831 and *6834), and only one is silent substitution (A*111502). The remaining alleles differ from their most similar alleles by two to six nucleotide substitutions.
Lazaro
A M
AM
Department of Oncology, C.W. Bill Young Marrow Donor Research and Recruitment Program, Georgetown University Medical Center, Washington, DC 20057, USA.
Xiao
Y
Y
Cao
K
K
Masaberg
C
C
Nichol
L
L
Ng
J
J
Hurley
C K
CK
Posch
P E
PE
D000483:Alleles; D019943:Amino Acid Substitution; D016172:DNA Fingerprinting; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization
D006680:HLA Antigens