title: Genetic variability in E6 and E7 genes of human papillomavirus -16, -18, -31 and -33 from HIV-1-positive women in Italy.
abstract: Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity were 1.2-3-3%, and 0.8-1.8 for E6 and 0.6-2.7%, and 0.6-2.0% for E7, respectively. HPV-31, the second most common HPV type, showed the highest diversity for both regions. On the whole, 26 out of 59 mutations were non-synonymous. The variability of these proteins may have implications in HPV vaccine strategies.
authors: Laboratory of Virology, Lazzaro Spallanzani National Institute of Infectious Diseases INMI, Rome, Italy.
authors: Anna Rosa
authors: AR
authors: Garbuglia
authors: Fabrizio
authors: F
authors: Carletti
authors: Claudia
authors: C
authors: Minosse
authors: Pierluca
authors: P
authors: Piselli
authors: M Stefania
authors: MS
authors: Zaniratti
authors: Diego
authors: D
authors: Serraino
authors: M Rosaria
authors: MR
authors: Capobianchi
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D005260:Female; D005814:Genes, Viral; D014644:Genetic Variation; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D007558:Italy; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D050725:Papillomavirus E7 Proteins / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*
chemical_list: D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins