title: Synthesis study of 2'-O-(2-methoxyethyl)-purine derivatives.
abstract: Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2'-O-MOE-purine derivatives is described.
authors: Institute of Bioorganic Chemistry, National Academy of Sciences, Minsk, Acad. Kuprevicha 5/2, Belarus. gsivets@yahoo.com
authors: Grigorii G
authors: GG
authors: Sivets
mesh_terms: D000478:Alkylation; D004980:Ethane / Q000031:analogs & derivatives* / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis*; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: C527038:1-methanesulfonyloxy-2-methoxyethane; D011684:Purine Nucleosides; D012263:Ribonucleosides; D013441:Sulfinic Acids; D004980:Ethane