title: Prediction of microvascular invasion before curative resection of hepatocellular carcinoma.
abstract: BACKGROUND
  The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion.
  
  
  METHODS
  We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed.
  
  
  RESULTS
  The 5-year disease-free survival (DFS) rate was 39.4%(median follow-up duration: 35 months). On resection pathology, 38.9% (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade > or =2 had higher incidences (7/18 patients, 38.8%) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly.
  
  
  CONCLUSIONS
  Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Beom Kyung
authors: BK
authors: Kim
authors: Kwang Hyub
authors: KH
authors: Han
authors: Young Nyun
authors: YN
authors: Park
authors: Mi Suk
authors: MS
authors: Park
authors: Kyung Sik
authors: KS
authors: Kim
authors: Jin Sub
authors: JS
authors: Choi
authors: Byung Soo
authors: BS
authors: Moon
authors: Chae Yoon
authors: CY
authors: Chon
authors: Young Myoung
authors: YM
authors: Moon
authors: Sang Hoon
authors: SH
authors: Ahn
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome