The NADH oxidase-Prx system in Amphibacillus xylanus.
Amphibacillus NADH oxidase belongs to a growing new family of peroxiredoxin-linked oxidoreductases including alkyl hydroperoxide reductase F (AhpF). Like AhpF it displays extremely high hydroperoxide reductase activity in the presence of a Prx, thus making up the NADH oxidase-Prx system. The NADH oxidase primarily catalyzes the reduction of oxygen by NADH to form H2O2, while the Prx immediately reduces H2O2 (or ROOH) to water (or ROH). Consequently, the NADH oxidase-Prx system catalyzes the reduction of both oxygen and hydrogen peroxide to water with NADH as the preferred electron donor. The NADH oxidase-Prx system is widely distributed in aerobically growing bacteria lacking a respiratory chain and catalase, and plays an important role not only in scavenging hydroperoxides but also in regenerating NAD in these bacteria.
Niimura
Youichi
Y
Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
D000332:Aerobiosis / Q000502:physiology; D001406:Bacillaceae / Q000201:enzymology*; D001426:Bacterial Proteins / Q000378:metabolism*; D002374:Catalase; D004579:Electron Transport; D006861:Hydrogen Peroxide / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D054464:Peroxiredoxins / Q000378:metabolism*; D014867:Water / Q000378:metabolism
D001426:Bacterial Proteins; D009097:Multienzyme Complexes; D014867:Water; D009243:NAD; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D002374:Catalase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D010100:Oxygen