title: [Amylase-producing multiple myeloma: a case report].
abstract: A 80-year-old man was admitted because of acute-onset thrombocytopenia and renal failure. He was diagnosed with Bence Jones (lambda) -type multiple myeloma associated with sepsis with methicillin-resistant Staphylococcus aureus. On admission, serum amylase activity was elevated to 1,814 IU/l (98% salivary type; S-amylase). Several days after admission, he developed bilateral myelomatous pleuritis. The activity of S-amylase in the effusion was 5,495 IU/l. Myeloma cells in the pleural effusion were positive for cytoplasmic amylase with an antibody against human amylase. High S-amylase activity was detected in the supernatant of cultured myeloma cells in the effusion. Furthermore, S-amylase gene expression was detected by RT-PCR. A diagnosis of amylase-producing multiple myeloma was made. The patient died of renal insufficiency complicated by severe DIC. We report a rare case of amylase-producing myeloma confirmed by immunocytochemistry, culture method, and gene expression.
authors: Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital.
authors: Minako
authors: M
authors: Mori
authors: Hayato
authors: H
authors: Maruoka
authors: Yuya
authors: Y
authors: Nagai
authors: Haruhiko
authors: H
authors: Fujita
authors: Katsuhiro
authors: K
authors: Togami
authors: Sumie
authors: S
authors: Tabata
authors: Masahiro
authors: M
authors: Kurata
authors: Akiko
authors: A
authors: Matsushita
authors: Kenichi
authors: K
authors: Nagai
authors: Kyoko
authors: K
authors: Tanaka
authors: Akiko
authors: A
authors: Yamashiro
authors: Takayuki
authors: T
authors: Takahashi
mesh_terms: D000369:Aged, 80 and over; D000681:Amylases / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000201:enzymology*
chemical_list: D000681:Amylases