title: F2L, a peptide derived from heme-binding protein, inhibits LL-37-induced cell proliferation and tube formation in human umbilical vein endothelial cells.
abstract: F2L, a peptide derived from heme-binding protein, was originally identified as an endogenous ligand for formyl peptide receptor-like (FPRL)2. Previously, we reported that F2L inhibits FPR and FPRL1-mediated signaling in neutrophils. Since endothelial cells express functional FPRL1, we examined the effect of F2L on LL-37 (an FPRL1 agonist)-induced signaling in human umbilical vein endothelial cells (HUVECs). F2L stimulated the chemotactic migration in HUVECs. However, F2L inhibited FPRL1 activity, resulting in the inhibition of cell proliferation and tube formation induced by LL-37 in HUVECs. We suggest that F2L will potentially be useful in the study of FPRL1 signaling and the development of drugs to treat diseases involving the FPRL1 in the vascular system.
authors: Department of Biochemistry, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors: Sun Young
authors: SY
authors: Lee
authors: Mi-Sook
authors: MS
authors: Lee
authors: Ha Young
authors: HY
authors: Lee
authors: Sang Doo
authors: SD
authors: Kim
authors: Jae Woong
authors: JW
authors: Shim
authors: Seong Ho
authors: SH
authors: Jo
authors: Jae Won
authors: JW
authors: Lee
authors: Joon Youn
authors: JY
authors: Kim
authors: Young-Whan
authors: YW
authors: Choi
authors: Suk-Hwan
authors: SH
authors: Baek
authors: Sung Ho
authors: SH
authors: Ryu
authors: Yoe-Sik
authors: YS
authors: Bae
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D010455:Peptides / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects*; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D002630:Chemotactic Factors; C498127:F2L peptide, human; D010455:Peptides; D054804:Cathelicidins