The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis.
OBJECTIVE
To investigate the associations between endometriosis and the G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1), and serum and peritoneal fluid MCP-1 levels in Korean women.


METHODS
The G(-2518)A polymorphism of MCP-1 was analyzed by restriction fragment length polymorphism in 105 women with and in 101 women without endometriosis. Serum and peritoneal fluid MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).


RESULTS
The genotype frequencies of the MCP-1 G (-2518)A polymorphism were GG 36.9%, AG 52.9%, and AA 10.2%. MCP-1 genotype frequencies and serum and peritoneal fluid MCP-1 levels were similar in those with or without endometriosis and were not dependent on disease stage. A significant correlation was found between serum and peritoneal fluid levels of MCP-1. However, no differences were found between MCP-1 genotypes in terms of serum and peritoneal fluid MCP-1 levels.


CONCLUSIONS
Serum and peritoneal fluid MCP-1 levels and the G (-2518)A MCP-1 polymorphism were found not to be associated with endometriosis in Korean women.
Kim
Ja Yeon
JY
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, Republic of Korea.
Kim
Hoon
H
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Kim
Jung Gu
JG
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014591:Uterine Diseases / Q000235:genetics*
D018932:Chemokine CCL2