title: IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis.
abstract: Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [18F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.
authors: Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku. nisao@kochi-u.ac.jp
authors: Isao
authors: I
authors: Nishimori
authors: Takuhiro
authors: T
authors: Kohsaki
authors: Saburo
authors: S
authors: Onishi
authors: Taro
authors: T
authors: Shuin
authors: Shino
authors: S
authors: Kohsaki
authors: Yasuhiro
authors: Y
authors: Ogawa
authors: Manabu
authors: M
authors: Matsumoto
authors: Makoto
authors: M
authors: Hiroi
authors: Hideaki
authors: H
authors: Hamano
authors: Shigeyuki
authors: S
authors: Kawa
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D049268:Positron-Emission Tomography; D011467:Prostate / Q000276:immunology / Q000473:pathology; D011472:Prostatitis / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology
chemical_list: D007074:Immunoglobulin G