End-stage renal disease following carboplatin chemotherapy for a nasopharyngeal carcinoma.
Renal failure secondary to carboplatin therapy is due to acute tubular necrosis and is usually reversible. However, acute renal failure with rapid progression to end-stage renal disease is an exceedingly rare complication of carboplatin therapy. The authors report a case of definitive renal failure secondary to carboplatin chemotherapy for a nasopharyngeal carcinoma. The mechanisms that give rise to the chronic nephropathy are discussed.
Tarrass
Faissal
F
Department of Nephrology and Dialysis, Ibn Rochd University Hospital Center, Casablanca, Morocco. faissal176@hotmail.com
Benmensour
Mostafa
M
Bayla
Abdelaziz
A
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D016190:Carboplatin