title: Salarins a and B and tulearin a: new cytotoxic sponge-derived macrolides.
abstract: Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.
authors: School of Chemistry, and Department of Zoology, Cell and Developmental Biology, Tel Aviv University, Ramat Aviv 69978, Israel.
authors: Ashgan
authors: A
authors: Bishara
authors: Amira
authors: A
authors: Rudi
authors: Maurice
authors: M
authors: Aknin
authors: Drorit
authors: D
authors: Neumann
authors: Nathalie
authors: N
authors: Ben-Califa
authors: Yoel
authors: Y
authors: Kashman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007814:Larva / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008270:Madagascar; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C526618:salarin A; C526619:salarin B