Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy.
OBJECTIVE
To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART).


METHODS
Interventional case report.


METHODS
Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART.


RESULTS
Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year.


CONCLUSIONS
Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
Kim
Stephen J
SJ
The Johns Hopkins Hospital, The Wilmer Eye Institute, Ophthalmology, Baltimore 21205, USA.
Equi
Robert
R
Belair
Marie-Lyne
ML
Fine
Howard F
HF
Dunn
James P
JP
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014785:Vision, Ocular / Q000502:physiology*
D000998:Antiviral Agents; D012367:RNA, Viral; D017245:Foscarnet; D014633:Valine; D000077483:Valacyclovir; D015774:Ganciclovir; D000212:Acyclovir