title: Elastic tissue damage in cephalic acquired cutis laxa.
abstract: Cutis laxa is a rare condition characterized by diminished elastic tissue. We report the histological changes from a 22-year-old male patient, who presented since 4 years hanging and inelastic facial skin, giving him an older appearance. The palpebral, preauricular and submandibular skin obtained after a facelift were examined. Conventional light microscopy with hematoxylin-eosin staining showed perivascular lymphocytic infiltrates and crossed-over collagen fibers. With Weigert staining, a lessening of elastic fibers with fragmentation, shortening and clumping was seen. The oxytalanic fibers in the papillary dermis were also affected, ranging from absence or reduction to flattening with clumping of the fibers, giving an irregular contour to the basal membrane zone. These findings were more intense in the palpebral skin. Transmission electronic microscopy showed reduction of the elastic fibers, a granular degeneration of the elastic tissue was found and collagen fibers were normal. Similar to light microscopy, at the ultrastructural level, the basal membrane has an irregular contour.
authors: Department of Dermatology, Catholic University of Pelotas, Pelotas, Brazil. hiramalmeidajr@hotmail.com
authors: Hiram Larangeira
authors: HL
authors: de Almeida
authors: Manfred
authors: M
authors: Wolter
authors: Márcia Vargas
authors: MV
authors: de Farias
authors: Luis Antônio Suita
authors: LA
authors: de Castro
mesh_terms: D000328:Adult; D003483:Cutis Laxa / Q000473:pathology* / Q000601:surgery; D004547:Elastic Tissue / Q000601:surgery / Q000648:ultrastructure*; D006257:Head; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D013194:Staining and Labeling; D013518:Surgery, Plastic; D016896:Treatment Outcome