Successful combination of antifungal agents and surgical resection for pulmonary aspergillosis in a child with Hodgkin disease: review of the literature.
The authors report on a 14-year-old adolescent boy suffering of Hodgkin disease in remission, who developed autoimmune anemia and thrombopenia. He was treated with high-dose steroids and he developed serious invasive lung aspergillosis, which was treated with antifungal agents and surgical intervention. Children suffering from cancer are prone to develop systemic fungal infections secondary to the severe immunosuppression caused by the disease itself and the antineoplastic therapy. Intravenous antifungal medications and, when feasible, surgery are used for treatment of pulmonary aspergillosis. Factors related to better outcome are early diagnosis, remission of underlying disease, aggressive antifungal therapy, and recovery from neutropenia.
Doganis
Dimitrios
D
Oncology Department, Children's Hospital Aglaia Kyriakou, Athens, Greece. doganisd@otenet.gr
Baka
Margarita
M
Pourtsidis
Apostolos
A
Bouhoutsou
Despina
D
Varvoutsi
Maria
M
Stamos
Georgios
G
Anastasiou
Nikolaos
N
Androulakakis
Emmanouel
E
Vasilatou-Kosmidis
Helen
H
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage*; D000740:Anemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D000935:Antifungal Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D001761:Bleomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D011859:Radiography; D014747:Vinblastine / Q000008:administration & dosage
D000935:Antifungal Agents; D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D000666:Amphotericin B; D011241:Prednisone