Eukaryotic initiation factor 4E.
Eukaryotic translation initiation factor 4E (eIF4E) is perhaps best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. However, recent studies have highlighted that eIF4E has many additional functions, which include the nuclear export of specific mRNAs as well as roles in ageing and the translation of some uncapped viral RNAs. This review aims to update the reader on recent developments, including the potential of eIF4E as a therapeutic target.
Goodfellow
Ian G
IG
Department of Virology, Imperial College London, Norfolk Place, London W2 1PG, UK. I.Goodfellow@Imperial.ac.uk
Roberts
Lisa O
LO
D021581:Active Transport, Cell Nucleus / Q000235:genetics; D039561:Eukaryotic Initiation Factor-4E / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D039561:Eukaryotic Initiation Factor-4E; D012315:RNA Caps; D012333:RNA, Messenger