Early local intracoronary platelet activation after drug-eluting stent placement.
BACKGROUND
Early local platelet activation after coronary intervention identifies patients at increased risk of acute stent thrombosis (AST). However, early changes in platelet activation in coronary circulation following drug-eluting stent (DES) implantation have never been reported.


METHODS
In a prospective study of 26 consecutive elective stable angina patients, platelet activation was analyzed by measuring soluble glycoprotein V (sGPV) and P-selectin (CD62P) before and after implantation of either DES or bare metal stent (BMS). All patients were pretreated with clopidogrel (300 mg loading dose) and aspirin (75 mg orally) the day before the procedure. Blood samples were drawn from the coronary ostium and 10 - 20 mm distal to the lesion site.


RESULTS
Consistent with the lower baseline clinical risk, the levels of CD62P and sGPV were within normal reference range, both in the coronary ostium and distal to the lesion before percutaneous coronary intervention (PCI) procedure. The levels of CD62P and sGPV did not change significantly (CD62P: (31.1 +/- 9.86) ng/ml vs (29.5 +/- 9.02) ng/ml, P = 0.319 and sGPV: (52.4 +/- 13.5) ng/ml vs (51.8 +/- 11.7) ng/ml, P = 0.674, respectively) after stent implantation when compared with baseline. Changes in these platelet activation markers did not differ between stent types.


CONCLUSIONS
Intracoronary local platelet activation does not occur in stable angina patients before and immediately following DES implantation when dual anti-platelet is administered.
Mahemuti
Ailiman
A
Department of Cardiology and UPRES EA3920-IFR133, University of Franche-Comte Medical School, Jean-Minjoz University Hospital, Bensancon, France. xahzad@hotmail.com
Meneveau
Nicolas
N
Seronde
Marie-France
MF
Schiele
Francois
F
Mercier
Mariette
M
Racadot
Evelyne
E
Bassand
Jean-Pierre
JP
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000601:surgery*; D015415:Biomarkers; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D011446:Prospective Studies
D015415:Biomarkers; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins