Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum.
Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin I (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 microM, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 microM.
Lin
Zhenjian
Z
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Zhu
Tianjiao
T
Fang
Yuchun
Y
Gu
Qianqun
Q
Zhu
Weiming
W
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D051379:Mice; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry* / Q000302:isolation & purification; D043803:Phenalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029623:Primulaceae / Q000382:microbiology*; D012015:Reference Standards; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C530590:9-demethyl FR-901235; D003512:Cyclohexanones; D018942:Macrolides; D043803:Phenalenes; D010636:Phenols; C530589:arugosin I; C530587:leptosphaerone C; C530588:penicillenone