How genes find their way inside the cell nucleus.
Recent progress in live cell imaging suggests a role for nuclear actin in chromatin movement. In this issue, for the first time, a gene locus moving toward a subnuclear compartment was tracked. Motion of the locus is actin dependent, raising the question of whether chromatin movements are random or directed.
Carmo-Fonseca
Maria
M
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. carmo.fonseca@fm.ul.pt
D000199:Actins / Q000502:physiology; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism*; D022003:Cell Nucleus Structures; D002843:Chromatin / Q000378:metabolism* / Q000502:physiology; D002875:Chromosomes / Q000378:metabolism / Q000502:physiology; D020541:Coiled Bodies / Q000378:metabolism / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D008957:Models, Genetic
D000199:Actins; D002843:Chromatin