title: Expression of Glut-1 in primary and recurrent head and neck squamous cell carcinomas, and compared with 2-[18F]fluoro-2-deoxy-D-glucose accumulation in positron emission tomography.
abstract: The aim of the study was to investigate the pattern of glucose transporter-1 (Glut-1) expression in primary and recurrent head and neck squamous cell carcinomas (HNSCCAs) and the relation between Glut-1 expression and 2-[18F]fluoro-2-deoxy-D-glucose - positron emission tomography (FDG-PET). Standardised uptake values (SUVs) were used to evaluate FDG uptake by the tumour. Sections were stained immunohistochemically for Glut-1, which showed that high SUVs were seen in all HNSCCAs, and patients with higher T stage tumours or less well-differentiated tumours showed significantly higher SUVs than those with lower stage tumours or better-differentiated tumours (P=0.001 and 0.04, respectively). Glut-1 immunostaining was present in all cases. The Glut-1 staining index in primary HNSCCAs was significantly lower than that in recurrent HNSCCAs (P=0.03), and the index of better-differentiated tumours lower than that of poorly-differentiated tumours (P=0.02). However, there was no significant correlation between SUV(mean) and the Glut-1 staining index. In conclusion, our data suggest that high FDG uptakes were seen with overexpression of Glut-1 in primary and recurrent HNSCCAs. SUV(mean) was related to tumour T stage and grade of differentiation, which indicated that SUV was helpful in evaluating tumours. The expression of Glut-1 in recurrent HNSCCAs was higher than that in primary HNSCCAs, and in poorly-differentiated HNSCCAs higher than in better-differentiated HNSCCAs, which indicated that Glut-1 may have a useful role as a predictor for poor prognosis in HNSCCAs. However, there was no significant correlation between FDG accumulation and Glut-1 expression.
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, P. R. China.
authors: Sheng-Jiao
authors: SJ
authors: Li
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, P. R. China. Electronic address: guoweishh@163.com.
authors: Wei
authors: W
authors: Guo
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, P. R. China.
authors: Guo-Xin
authors: GX
authors: Ren
authors: Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, P. R. China.
authors: Gang
authors: G
authors: Huang
authors: Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, P. R. China.
authors: Tao
authors: T
authors: Chen
authors: Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, P. R. China.
authors: Shao-Li
authors: SL
authors: Song
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011817:Rabbits; D019275:Radiopharmaceuticals
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18