title: Proresorptive actions of FSH and bone loss.
abstract: We review studies that propose follicle-stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor.
authors: Mount Sinai Bone Program, The Mount Sinai School of Medicine, New York, NY 10029, USA.
authors: Mone
authors: M
authors: Zaidi
authors: Harry C
authors: HC
authors: Blair
authors: Jameel
authors: J
authors: Iqbal
authors: Ling Ling
authors: LL
authors: Zhu
authors: T Rajendra
authors: TR
authors: Kumar
authors: Alberta
authors: A
authors: Zallone
authors: Li
authors: L
authors: Sun
mesh_terms: D000818:Animals; D001862:Bone Resorption; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006801:Humans
chemical_list: D005640:Follicle Stimulating Hormone