title: Quantitative EEG in early Alzheimer's disease patients - power spectrum and complexity features.
abstract: The goal of this study was to investigate the EEG signs of early stage Alzheimer's disease (AD) by conventional analyses and by methods quantifying linear and nonlinear EEG-complexity. The EEG was recorded in 12 mild AD patients and in an age-matched healthy control group (24 subjects) in both eyes open and eyes closed conditions. Frequency spectra, Omega-complexity and Synchronization likelihood were calculated on the data. In the patients a significant decrease of the relative alpha and increase of the theta power were found. Remarkably increased Omega-complexity and lower Synchronization likelihood were observed in AD in the 0.5-25 Hz frequency ranges. It is concluded that both spectral- and EEG-complexity changes can be found already in the early stage of AD in a wide frequency range. Application of conventional EEG analysis methods in combination with quantification of EEG-complexity may improve the chances of early diagnosis of AD.
authors: Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary. bazsoczi@yahoo.com
authors: Balázs
authors: B
authors: Czigler
authors: Dóra
authors: D
authors: Csikós
authors: Zoltán
authors: Z
authors: Hidasi
authors: Zsófia
authors: Z
authors: Anna Gaál
authors: Eva
authors: E
authors: Csibri
authors: Eva
authors: E
authors: Kiss
authors: Pál
authors: P
authors: Salacz
authors: Márk
authors: M
authors: Molnár
mesh_terms: D000368:Aged; D000513:Alpha Rhythm / Q000379:methods*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D017711:Nonlinear Dynamics; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013223:Statistics as Topic; D013826:Theta Rhythm / Q000379:methods*