Photon radiotherapy for the treatment of high-grade gliomas.
High-grade gliomas are diseases characterized by poor overall survival despite aggressive multimodality therapy. Radiation therapy has been unequivocally established as the mainstay of therapy after surgical intervention, regardless of the extent of surgical resection. Despite theoretical and technological advances in the planning and delivery of radiation therapy, overall survival remains grim. In this review, we outline the evolution of radiation therapy, report the pivotal trials that have shaped this therapy and speculate on the future direction of this field.
Hwang
Catherine S
CS
Northwestern University, Department of Radiation Oncology, Feinberg School of Medicine, 251 East Huron Avenue, Galter Pavilion LC-178, Chicago, IL 60611, USA. chwang003@md.northwestern.edu
Marymont
Maryann H
MH
Muro
Kenji
K
D001254:Astrocytoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D001918:Brachytherapy / Q000379:methods; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D019635:Neurosurgical Procedures / Q000379:methods; D017785:Photons / Q000627:therapeutic use*; D011379:Prognosis; D011832:Radiation Injuries / Q000517:prevention & control; D016634:Radiosurgery / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome