title: Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT.
abstract: Recent advances in murine cardiac studies with three-dimensional (3D) cone beam micro-CT used a retrospective gating technique. However, this sampling technique results in a limited number of projections with an irregular angular distribution due to the temporal resolution requirements and radiation dose restrictions. Both angular irregularity and undersampling complicate the reconstruction process, since they cause significant streaking artifacts. This work provides an iterative reconstruction solution to address this particular challenge. A sparseness prior regularized weighted l2 norm optimization is proposed to mitigate streaking artifacts based on the fact that most medical images are compressible. Total variation is implemented in this work as the regularizer for its simplicity. Comparison studies are conducted on a 3D cardiac mouse phantom generated with experimental data. After optimization, the method is applied to in vivo cardiac micro-CT data.
authors: Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors: Jiayu
authors: J
authors: Song
authors: Qing H
authors: QH
authors: Liu
authors: G Allan
authors: GA
authors: Johnson
authors: Cristian T
authors: CT
authors: Badea
mesh_terms: D000465:Algorithms; D000818:Animals; D006321:Heart / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016018:Least-Squares Analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D015233:Models, Statistical; D009206:Myocardium / Q000378:metabolism; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014965:X-Rays