Seidel-Herzel model of human baroreflex in cardiorespiratory system with stochastic delays.
The stochastic versus deterministic solution of the Seidel-Herzel model describing the baroreceptor control loop (which regulates the short-time heart rate) are compared with the aim of exploring the heart rate variability. The deterministic model solutions are known to bifurcate from the stable to sustained oscillatory solutions if time delays in transfer of signals by sympathetic nervous system to the heart and vasculature are changed. Oscillations in the heart rate and blood pressure are physiologically crucial since they are recognized as Mayer waves. We test the role of delays of the sympathetic stimulation in reconstruction of the known features of the heart rate. It appears that realistic histograms and return plots are attainable if sympathetic time delays are stochastically perturbed, namely, we consider a perturbation by a white noise. Moreover, in the case of stochastic model the bifurcation points vanish and Mayer oscillations in heart period and blood pressure are observed for whole considered space of sympathetic time delays.
Dudkowska
Aleksandra
A
Institute of Theoretical Physics and Astrophysics, University of Gdańsk ul, Wita Stwosza 57, 80-952, Gdańsk, Poland. ola@iftia9.univ.gda.pl
Makowiec
Danuta
D
D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D003331:Coronary Vessels / Q000294:innervation; D006321:Heart / Q000294:innervation; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009991:Oscillometry; D011311:Pressoreceptors / Q000502:physiology; D013269:Stochastic Processes; D013997:Time Factors