Comparative study of several sinusitis experimental modelling techniques in rabbits.
Experimental models for clinical studies of rhinosinusitis are needed.


OBJECTIVE
to define a reliable, solid and reproducible experimental model for inflammatory rhinosinusitis with no innoculation of infectious agents in rabbits.


METHODS
Experimental.


METHODS
Twenty 20 rabbits were divided into 4 groups submitted to 4 different interventions: the placement of a unilateral nasal fossa sponge, unilateral obliteration of the nasal ostium with cyanoacrylate, unilateral placement of antigens in the maxillary cavity and unilateral placement of blood in the maxillary cavity. The animals were monitored for 15 days and then anesthetized and sacrificed; the maxillary sinuses were evaluated histologicaly and results were compared with controls and between the intervention groups.


CONCLUSIONS
Sponje and glue as agents of meatal obstruction and toxoid applied in the antrum are efficient as methods for rhinosinusitis modeling. Blood was not efficient in producing sinusitis.
Costa
Henrique Olival
HO
Otorhinolaryngology Department, São Paulo Santa Casa.
Ruschi e Luchi
Giulliano Enrico
GE
Augusto
Arthur Guilerme
AG
Castro
Marilia
M
de Souza
Flavia Coelho
FC
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D011817:Rabbits; D012220:Rhinitis / Q000473:pathology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000473:pathology*