title: Distribution of secretory inhibitor of platelet microbicidal protein among urethral isolates with its correlation with prostatitis.
abstract: OBJECTIVE
  To report the detection in vitro of secretory inhibitor of platelet microbicidal protein (SIPMP) phenotypes of urethral isolates along with a comparison with isolates from patients with or without chronic bacterial prostatitis (CBP).
  
  
  METHODS
  Urethral isolates of Staphylococcus spp. (n=4), diphtheroids (n=28), micrococci (n=15), streptococci (n=21), Enterobacteriaceae (n=9) and Enterococcus faecalis (n=19) from patients with or without CBP were tested. SIPMP production was tested by inhibition of platelet microbicidal protein (PMP) bioactivity against Bacillus subtilis and was expressed as percentage of inhibition of PMP bactericidal activity.
  
  
  RESULTS
  A significantly higher proportion of CBP-strains (57.78% vs. 16.67%) reduced PMP-induced killing of Bacillus subtilis than non-CBP strains did (P<0.01). SIPMP levels of staphylococci and Enterococcus faecalis from the CBP group were significantly higher than those of the control group.
  
  
  CONCLUSIONS
  These results suggest that SIPMP production is associated with the CBP source. Data from the present study might have significant implications for the understanding of the pathogenesis of CBP.
authors: Department of Human Microbiology, Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Volgogradskaya Street 36/3, Orenburg, Russia. ubi@mail.orb.ru
authors: Iuri B
authors: IB
authors: Ivanov
authors: Viktor A
authors: VA
authors: Gritsenko
authors: Michael D
authors: MD
authors: Kuzmin
mesh_terms: D001770:Blood Bactericidal Activity / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism*; D002908:Chronic Disease; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010641:Phenotype; D011472:Prostatitis / Q000378:metabolism* / Q000382:microbiology*; D014521:Urethra / Q000382:microbiology*; D001620:beta-Thromboglobulin / Q000037:antagonists & inhibitors*
chemical_list: C061615:PPBP protein, human; D001620:beta-Thromboglobulin