[Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis].
OBJECTIVE
To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).


METHODS
226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.


RESULTS
The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.


CONCLUSIONS
The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.
Qiu
Xu-sheng
XS
Spine Surgery, Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China.
Tang
Leung-sang
LS
Yeung
Hiu-yan
HY
Kwok
Hoi-kei
HK
Lee
Kwong-man
KM
Qin
Ling
L
Qiu
Yong
Y
Cheng
Chun-yiu
CY
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044122:Receptor, Melatonin, MT1 / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics*
D044122:Receptor, Melatonin, MT1