title: Effect of antioxidants and exercise on bone metabolism.
abstract: We examined the effects of antioxidant supplementation in association with progressive aerobic training on the bone metabolism of healthy elderly individuals. For 8 weeks, 13 participants (mean age 74 years) received vitamin C (500 mg) and vitamin E (100 mg) daily and participated in a supervised progressive aerobic training programme. After the 8 weeks, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations were increased significantly by 42.8% (P < 0.001) and 26.8% (P < 0.01) respectively, while parathyroid hormone concentration was decreased by 17.5% (p < 0.05). Of the bone markers, only bone alkaline phosphatase decreased, by 14.6% (P < 0.05). No variation was observed for ionized calcium, insulin-like growth factor-1 or insulin-like growth factor binding protein-3. Our findings suggest that 8 weeks of combined antioxidant supplementation and aerobic training modified vitamin D metabolism and parathyroid hormone concentration. These adaptations might counterbalance the unfavourable hormonal profile frequently observed in the elderly that predisposes them to accentuated age-related bone loss.
authors: Service de médicine nucléaire, Hôpital Lapeyronie, CHU Montpellier, France. laurent.maimoun@laposte.net
authors: Laurent
authors: L
authors: Maïmoun
authors: David
authors: D
authors: Simar
authors: Corinne
authors: C
authors: Caillaud
authors: Edouard
authors: E
authors: Peruchon
authors: Charles
authors: C
authors: Sultan
authors: Michel
authors: M
authors: Rossi
authors: Denis
authors: D
authors: Mariano-Goulart
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D015415:Biomarkers / Q000032:analysis; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000187:drug effects
chemical_list: D000975:Antioxidants; D015415:Biomarkers