[Alkaloid metabolites of mangrove endophytic fungus ZZF42 from the South China Sea].
Four compounds, apicidin (1), N-methylharman (2), cylo (Phe-Tyr) (3) and indole-3-acetic acid (4) were isolated from the mangrove endophytic fungus ZZF42 from the South China Sea. Their structures were elucidated by spectral data. Compound 1 was first isolated from the marine fungus. Compound 2 was firstly isolated from marine microorganism. Compound 1 exhibited selective in vitro cytotoxicity towards KB ahd KBv200 with IC50 values of less than 0.78 microg/ml.
Huang
Zhong-jing
ZJ
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Guo
Zhi-yong
ZY
Yang
Rui-yun
RY
She
Zhi-gang
ZG
Lin
Yong-cheng
YC
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007210:Indoleacetic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D043982:Rhizophoraceae / Q000382:microbiology*
D000470:Alkaloids; D000970:Antineoplastic Agents; D007210:Indoleacetic Acids; D010456:Peptides, Cyclic; C102351:apicidin; C030737:indoleacetic acid