title: The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis.
abstract: OBJECTIVE
  To investigate the associations between endometriosis and the G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1), and serum and peritoneal fluid MCP-1 levels in Korean women.
  
  
  METHODS
  The G(-2518)A polymorphism of MCP-1 was analyzed by restriction fragment length polymorphism in 105 women with and in 101 women without endometriosis. Serum and peritoneal fluid MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The genotype frequencies of the MCP-1 G (-2518)A polymorphism were GG 36.9%, AG 52.9%, and AA 10.2%. MCP-1 genotype frequencies and serum and peritoneal fluid MCP-1 levels were similar in those with or without endometriosis and were not dependent on disease stage. A significant correlation was found between serum and peritoneal fluid levels of MCP-1. However, no differences were found between MCP-1 genotypes in terms of serum and peritoneal fluid MCP-1 levels.
  
  
  CONCLUSIONS
  Serum and peritoneal fluid MCP-1 levels and the G (-2518)A MCP-1 polymorphism were found not to be associated with endometriosis in Korean women.
authors: Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, Republic of Korea.
authors: Ja Yeon
authors: JY
authors: Kim
authors: Hoon
authors: H
authors: Kim
authors: Chang Suk
authors: CS
authors: Suh
authors: Seok Hyun
authors: SH
authors: Kim
authors: Young Min
authors: YM
authors: Choi
authors: Jung Gu
authors: JG
authors: Kim
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014591:Uterine Diseases / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2