title: Why does exercise terminate at the maximal lactate steady state intensity?
abstract: OBJECTIVE
  The purpose of this study was to measure physiological responses during exercise performed until exhaustion at the exercise intensity corresponding to the maximal lactate steady state (MLSS) in order to determine why subjects stopped.
  
  
  METHODS
  Eleven male trained subjects performed a test at MLSS on a cycle ergometer until exhaustion.
  
  
  RESULTS
  Time to exhaustion was 55.0 (SD 8.5) min. No variation was observed between the 10th and the last minute for arterial pyruvate, bicarbonate, and haemoglobin concentrations, redox state, arterial oxygen pressure, arterial oxygen saturation, osmolality, haematocrit, oxygen uptake, carbon dioxide output, and gas exchange ratio (p>0.05). Arterial lactate concentration and arterial carbon dioxide pressure decreased significantly whereas pH, base excess and the Ratings of Perceived Exertion (RPE) increased significantly (p<0.05). Although respiratory rate, minute ventilation and heart rate increased significantly until exhaustion (p<0.05), values at termination of the MLSS test were significantly lower than values measured during a maximal exercise test (p<0.05). Blood ammonia concentrations rose progressively during the MLSS test. However, there is no known mechanism by which this change could cause peripheral fatigue.
  
  
  CONCLUSIONS
  Exercise termination was not associated with evidence of failure in any physiological system during prolonged exercise performed at MLSS. Thus the biological mechanisms of exercise termination at MLSS were compatible with an integrative homoeostatic control of peripheral physiological systems during exercise.
authors: Département STAPS, Université de La Réunion, 117 rue du Général Ailleret, 97430 Le Tampon, France. bertrand.baron@univ-reunion.fr
authors: B
authors: B
authors: Baron
authors: T D
authors: TD
authors: Noakes
authors: J
authors: J
authors: Dekerle
authors: F
authors: F
authors: Moullan
authors: S
authors: S
authors: Robin
authors: R
authors: R
authors: Matran
authors: P
authors: P
authors: Pelayo
mesh_terms: D000136:Acid-Base Equilibrium; D000328:Adult; D000641:Ammonia / Q000097:blood; D015308:Anaerobic Threshold / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005221:Fatigue / Q000097:blood / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D055815:Young Adult
chemical_list: D019344:Lactic Acid; D000641:Ammonia