Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components.
Heterologous differentiation in adipocytic tumors is a rare phenomenon. Only 4 cases of myxoid liposarcoma (MLS) with cartilaginous differentiation were thus far reported without confirmatory molecular assays. We describe a primary MLS with chondroid differentiation that affected the left thigh of a 47-year-old man. Histologically, multiple sharply demarcated chondroid nodules were embedded among the classic MLS area. By reverse transcription-polymerase chain reaction, the identical type II TLS-CHOP fusion gene transcripts were detected in both the liposarcomatous and microdissected chondroid tumor cells. Our case confirms the actual existence of MLS with cartilaginous differentiation and the neoplastic nature of chondroid component.
Wei
Yu-Ching
YC
Department of Pathology, Kaohsiung Medical Center, Chang Gung University Hospital College of Medicine, Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung County 833, Taiwan.
Li
Chien-Feng
CF
Eng
Hock-Liew
HL
Yeh
Ming-Chung
MC
Lin
Ching-Nan
CN
Huang
Hsuan-Ying
HY
D000328:Adult; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D013848:Thigh; D051742:Transcription Factor CHOP / Q000235:genetics*; D014158:Transcription, Genetic
D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D034702:RNA-Binding Protein FUS; C106030:TLS-CHOP fusion protein, human; D051742:Transcription Factor CHOP