Area of paradoxical signal drop after the administration of superparamagnetic iron oxide on the T2-weighted image of a patient with lymphangitic metastasis of the liver.
We report a geographic area of prominent hypointensity in T2-weighted images vs. normal adjacent liver parenchyma in a patient with cholangiocarcinoma and lymphangitic metastasis of the liver after superparamagnetic iron oxide (SPIO) administration. The area showing this prominent signal drop showed Kupffer cell proliferation and lymphangitic metastasis during a pathologic examination.
Lee
Youkyung
Y
Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Chongno-gu, Seoul 110-774, Korea.
Lee
Jong Seok
JS
Kim
Chang-Min
CM
Jeong
Jun Yong
JY
Choi
Joon-Il
JI
Kim
Min Ju
MJ
D049109:Cell Proliferation; D003287:Contrast Media / Q000494:pharmacology; D003911:Dextrans; D003937:Diagnosis, Differential; D005290:Ferric Compounds / Q000494:pharmacology*; D052203:Ferrosoferric Oxide; D005682:Gadolinium / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000494:pharmacology; D007728:Kupffer Cells / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010087:Oxides / Q000494:pharmacology; D014057:Tomography, X-Ray Computed / Q000379:methods
D003287:Contrast Media; D003911:Dextrans; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; C000499:ferric oxide; D005682:Gadolinium; D007501:Iron; D052203:Ferrosoferric Oxide