Characterization of nanoparticles for therapeutics.
Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy.
Hall
Jennifer B
JB
SAIC-Frederick Inc., Nanotechnology Characterization Laboratory, Advanced Technology Program, NCI-Frederick, 1050 Boyles St., Bldg. 469, Frederick, MD 21702, USA.
Dobrovolskaia
Marina A
MA
Patri
Anil K
AK
McNeil
Scott E
SE
D002626:Chemistry, Pharmaceutical / Q000639:trends*; D004337:Drug Carriers / Q000737:chemistry*; D050997:Nanomedicine / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure
D004337:Drug Carriers