title: [Non-herpetic acute limbic encephalitis-like manifestation in a case of Hashimoto's encephalopathy with positive autoantibodies against ionotropic glutamate receptor epsilon2].
abstract: A 37-year-old woman developed memory disturbance and seizures preceded by headache and high fever. Physical examination revealed persistent high fever, confusion, neck stiffness, anterograde and retrograde amnesia and disorientation. CSF showed pleocytosis and normal glucose level, and negative herpes simplex virus DNA on PCR. The fluid attenuated inversion recovery (FLAIR) MRI of the brain demonstrated nearly symmetric high signal intensity areas in the bilateral mesial temporal lobes. The tentative clinical diagnosis was non-herpetic acute limbic encephalitis (NHALE), and administration of methylprednisolone improved her conditions. Laboratory tests revealed mild hypothyroidism with high titers of serum antibodies against TPO and thyroglobulin, consistent with Hashimoto's disease. In addition, antibodies against amino terminal of alpha-enolase in the serum and those against glutamate receptor (GluR) epsilon2 in the serum and CSF were positive. A final diagnosis of Hashimoto's encephalopathy associated with GluRepsilon2 antibody was made. The present case suggests that NHALE-like clinical manifestation can be produced by autoimmune-mediated encephalopathies.
authors: Department of Neurology, Mie University Graduate School of Medicine.
authors: Akihiro
authors: A
authors: Shindo
authors: Yuichiro
authors: Y
authors: Ii
authors: Ryogen
authors: R
authors: Sasaki
authors: Yukitoshi
authors: Y
authors: Takahashi
authors: Makoto
authors: M
authors: Yoneda
authors: Shigeki
authors: S
authors: Kuzuhara
mesh_terms: D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D014408:Biomarkers, Tumor / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D020363:Limbic Encephalitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D020551:Pulse Therapy, Drug; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D025521:Tumor Suppressor Proteins; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase; D008775:Methylprednisolone