Spared caudal brainstem SERT binding in early Parkinson's disease.
Postmortem data indicate loss of serotoninergic neurons in Parkinson's disease (PD). We used the serotonin transporter (SERT) radioligand 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitril (DASB) and positron emission tomography to examine SERT distribution and changes in early PD subjects. We studied five PD subjects (H&Y 1 to 2.5) and eight normal controls. There is reduced SERT binding in PD. The magnitude of DASB binding reductions was greater in the forebrain than in the brainstem regions. There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei.
Albin
Roger L
RL
Geriatrics Research, Education, and Clinical Center, Ann Arbor VA, Ann Arbor, MI, USA. ralbin@umich.edu
Koeppe
Robert A
RA
Bohnen
Nicolaas I
NI
Wernette
Kristine
K
Kilbourn
Michael A
MA
Frey
Kirk A
KA
D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D001933:Brain Stem / Q000737:chemistry* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000737:chemistry / Q000473:pathology; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D016548:Prosencephalon / Q000737:chemistry / Q000473:pathology; D011485:Protein Binding / Q000502:physiology; D011869:Radioligand Assay; D050486:Serotonin Plasma Membrane Transport Proteins / Q000032:analysis* / Q000378:metabolism; D013997:Time Factors
D009419:Nerve Tissue Proteins; D050486:Serotonin Plasma Membrane Transport Proteins