title: Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice.
abstract: CD1 molecules present a variety of microbial glycolipids and self-glycolipids to T cells, but their potential role in humoral responses to glycolipid Ags remains to be established. To address this issue directly, we used GM1/GD1a-deficient mice, which, upon immunization with heat-killed Campylobacter jejuni, develop Guillain-Barré syndrome-associated IgG Abs against the GM1/GD1a sugar chain epitopes of bacterial lipo-oligosaccharides (LOS). Our results showed that anti-ganglioside Abs of the IgG1, IgG2b, and IgG3 isotypes were produced in the absence of group 2 CD1 (CD1d) expression. Unlike mouse and human group 2 CD1 molecules that specifically bound LOS, none of the group 1 CD1 molecules (CD1a, CD1b, and CD1c in humans) were capable of interacting with LOS. Thus, these results indicate CD1-independent pathways for anti-ganglioside Ab production.
authors: Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan.
authors: Yukie
authors: Y
authors: Matsumoto
authors: Nobuhiro
authors: N
authors: Yuki
authors: Luc
authors: L
authors: Van Kaer
authors: Koichi
authors: K
authors: Furukawa
authors: Koichi
authors: K
authors: Hirata
authors: Masahiko
authors: M
authors: Sugita
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D018949:Antigens, CD1 / Q000502:physiology*; D016123:Campylobacter jejuni / Q000276:immunology; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives / Q000235:genetics; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D007074:Immunoglobulin G / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains
chemical_list: D000906:Antibodies; D018949:Antigens, CD1; D005732:Gangliosides; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C064020:ganglioside GD1alpha; D005677:G(M1) Ganglioside