Stem cell treatment of dystrophic dogs.
Human muscular dystrophies are devastating and incurable inherited diseases. Hopes of progress towards therapy of muscular dystrophies were aroused when Sampaolesi et al. reported "extensive recovery of dystrophin expression, normal muscle...function", and "remarkable clinical amelioration" in golden retriever muscular dystrophy dogs treated with 'mesoangioblasts'. Here I re-examine their results, showing how their assessments might be flawed and their conclusions overstated. Further studies will be required to evaluate fully the clinical potential of this work.
Bretag
Allan H
AH
Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5000, Australia. a.bretag@unisa.edu.au
D000375:Aging; D000818:Animals; D015982:Bias; D018849:Controlled Clinical Trials as Topic / Q000639:trends; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology / Q000601:surgery*; D004285:Dogs; D016189:Dystrophin / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D009137:Muscular Dystrophy, Animal / Q000235:genetics / Q000503:physiopathology / Q000601:surgery*; D015203:Reproducibility of Results; D033581:Stem Cell Transplantation
D016189:Dystrophin