Synthesis of 1'-C-fluoromethyladenosine.
In search for new antiviral agents, we have been interested in 1'-C-fluoromethyl branched ribonucleosides. In this paper, we describe the synthesis of 1'-C-fluoromethyladenosine via electrophilic fluorination of exo-glycal.
Damont
Annelaure
A
Laboratoire Coopératif Idenix, CNRS, Université Montpellier II, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France.
Dukhan
David
D
Gosselin
Gilles
G
Peyronnet
Jérôme
J
Storer
Richard
R
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis*
C527075:1'-C-fluoromethyladenosine; D000998:Antiviral Agents; D000241:Adenosine