CHRONIC INSOMNIA AND STRESS SYSTEM.
SynopsisIn insomnia, which is a very common sleep disorder, objective sleep measures, EEG activity, physiologic findings, HPA axis activity and inflammation markers suggest that it is not a state of sleep loss, but a disorder of hyperarousal present both during the night and the daytime. Several psychological and physiological factors contribute to the onset and perpetuation of insomnia, such as anxious-ruminative personality traits, stressful events, age-related sleep homeostasis weakening mechanisms, menopause and biologic - genetic diathesis of CNS hyperarousal. The therapeutic approach in insomnia should be multidimensional reducing the overall emotional and physiologic hyperarousal and its underlying factors present throughout the 24-h sleep/wake period.
Basta
Maria
M
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Chrousos
George P
GP
Vela-Bueno
Antonio
A
Vgontzas
Alexandros N
AN