title: Two new antibacterial sesquiterpenoids from Centipeda minima.
abstract: Two new guaiane-type sesquiterpene lactones, compounds 1 and 2, along with three known guaianolide- or pseudoguaianolides, were isolated from Centipeda minima (whole plant). Their structures were identified by spectroscopic and mass-spectrometric analyses. The configuration at C5 of the guaiane framework of 1 was rationalized by quantum-mechanical calculations (Table 2). All compounds were found to be active against eight different microbial pathogens (Table 3), with MIC values in the range of 6.25-100 microg/ml.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors: Heng-Xing
authors: HX
authors: Liang
authors: Fu-Kai
authors: FK
authors: Bao
authors: Xiao-Ping
authors: XP
authors: Dong
authors: Hua-Jie
authors: HJ
authors: Zhu
authors: Xiao-Jie
authors: XJ
authors: Lu
authors: Ming
authors: M
authors: Shi
authors: Qing
authors: Q
authors: Lu
authors: Yong-Xian
authors: YX
authors: Cheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes