[Progress in understanding moleculr mechanisms of oncogenesis, and novel methods of tumor growth control].
Malignant tumor develop from cells with distorted signaling pathways controlling proliferation, migration, viability, differentiation, and genome integrity, as well as their influence on microenvironment. Progress in understanding molecular mechanisms of such alterations has led to the elaboration of new methods of anti-tumor therapy based on the modulation of the activity of molecules playing a key role in tumor development (so-called "target therapy"). The paper describes basic mechanisms of the development of cell features determining malignant phenotype and new possibilities for its correction. In particular, recent finding concerning the role of reactive oxygen species in oncogenesis and anti-tumor therapy are considered.
Agapova
L S
LS
Kopnin
B P
BP
D002273:Carcinogens; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D015398:Signal Transduction / Q000502:physiology
D002273:Carcinogens; D016207:Cytokines