New cationic polyprenyl derivative proposed as a lipofecting agent.
Cationic linear poly-cis-isoprenoid prepared from natural plant polyprenol in a mixture with dioleyl phosphatidylethanolamine was found to be an effective lipofection agent for eukaryotic cells. The transfecting activity is related to the poly-cis structure of the polyprenyl chain.
Madeja
Zbigniew
Z
Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. z.madeja@uj.edu.pl
Rak
Monika
M
Wybieralska
Ewa
E
Rózański
Igor
I
Masnyk
Marek
M
Chmielewski
Marek
M
Lysek
Robert
R
Chojnacki
Tadeusz
T
Jankowski
Wiesław
W
Ciepichal
Ewa
E
Swiezewska
Ewa
E
Tekle
Michael
M
Dallner
Gustav
G
D002412:Cations; D045744:Cell Line, Tumor; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D009387:Neoprene / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010944:Plants / Q000737:chemistry; D014162:Transfection
D002412:Cations; D008055:Lipids; D010714:Phosphatidylethanolamines; C016077:prenyl; C483858:phosphatidylethanolamine; D009387:Neoprene