title: CyberKnife radiosurgical rhizotomy for the treatment of atypical trigeminal nerve pain.
abstract: OBJECTIVE
  Patients with atypical trigeminal neuralgia (TN) have unilateral pain in the trigeminal distribution that is dull, aching, or burning in nature and is constant or nearly constant. Studies of most radiosurgical and surgical series have shown lower response rates in patients with atypical TN. This study represents the first report of the treatment of atypical TN with frameless CyberKnife stereotactic radiosurgery (SRS).
  
  
  METHODS
  Between 2002 and 2007, 7 patients that satisfied the criteria for atypical TN and underwent SRS were included in our study. A 6-8-mm segment of the trigeminal nerve was targeted, excluding the proximal 3 mm at the brainstem. All patients were treated in a single session with a median maximum dose of 78 Gy and a median marginal dose of 64 Gy.
  
  
  RESULTS
  Outcomes in 7 patients with a mean age of 61.6 years and a median follow-up of 20 months are reported. Following SRS, 4 patients had complete pain relief, 2 had minimal pain relief with some decrease in the intensity of their pain, and 1 patient experienced no pain relief. Pain relief was reported within 1 week of SRS in 4 patients and at 4 months in 2 patients. After a median follow-up of 28 months, pain did not recur in any of the 4 patients who had reported complete pain relief. Complications after SRS included bothersome numbness in 3 patients and significant dysesthesias in 1 patient.
  
  
  CONCLUSIONS
  The authors have previously reported a 90% rate of excellent pain relief in patients with classic TN treated with CyberKnife SRS. Compared with patients with classic TN, patients with atypical TN have a lower rate of pain relief. Nevertheless, the nearly 60% rate of success after SRS achieved in this study is still comparable to or better than results achieved with any other treatment modality for atypical TN.
authors: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305-5327, USA. chiragpatil@gmail.com
authors: Chirag G
authors: CG
authors: Patil
authors: Anand
authors: A
authors: Veeravagu
authors: Regina S
authors: RS
authors: Bower
authors: Gordon
authors: G
authors: Li
authors: Steven D
authors: SD
authors: Chang
authors: Michael
authors: M
authors: Lim
authors: John R
authors: JR
authors: Adler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D019051:Rhizotomy / Q000379:methods*; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000601:surgery*