title: Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects.
abstract: OBJECTIVE
  The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study.
  
  
  RESULTS
  Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean +/- SD age 43.8 +/- 8.3 years, BMI 25.5 +/- 4.0 kg/m(2)] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) mum, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011).
  
  
  CONCLUSIONS
  Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.
authors: Department of Medicine, University of Melbourne, Austin Health, Heidelberg Repatriation Hospital, Victoria, Australia.
authors: Sheila
authors: S
authors: Patel
authors: Allan
authors: A
authors: Flyvbjerg
authors: Michaela
authors: M
authors: Kozàkovà
authors: Jan
authors: J
authors: Frystyk
authors: Ibrahim M
authors: IM
authors: Ibrahim
authors: John R
authors: JR
authors: Petrie
authors: Peter J
authors: PJ
authors: Avery
authors: Ele
authors: E
authors: Ferrannini
authors: Mark
authors: M
authors: Walker
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D005260:Female; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D052242:Adiponectin; D015415:Biomarkers