title: Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits.
abstract: OBJECTIVE
  To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis.
  
  
  METHODS
  Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was induced through retrograde injection of 5% sodium taurocholate (1 mL/kg weight) in the main pancreatic duct. After 3 hours, they were randomized to receive endovenous iodinized nonionic contrast medium (group 1), iodinized ionic contrast medium (group 2), gadoteric acid (group 3), and physiological serum at 0.9% (group 4). Six hours after induction of pancreatitis, these animals were reoperated. During surgery, pancreatic tissue flow through laser Doppler, hematometric values, biochemistry, and histopathology analysis by hematoxylin and eosin were done. Statistical analysis using Kruskal-Wallis, Fisher-Freeman-Halton, and parametric t tests was performed.
  
  
  RESULTS
  There was statistical significance when comparing tissue flow before and after induction of pancreatitis (P < 0.0001). Ionic and nonionic contrast media and gadoteric acid did not increase the grade of pancreatic necrosis (P > 0.05).
  
  
  CONCLUSIONS
  Ionic and nonionic contrast media and gadoteric acid did not produce adverse effects in the present model of acute necrotizing pancreatitis.
authors: Department of Surgery, Discipline of Gastric Surgery, Federal University of São Paulo, São Paulo, Brazil. apodaca@uol.com.br
authors: Franz R
authors: FR
authors: Apodaca-Torrez
authors: Alberto
authors: A
authors: Goldenberg
authors: Edson J
authors: EJ
authors: Lobo
authors: José F M
authors: JF
authors: Farah
authors: Tarcisio
authors: T
authors: Triviño
authors: Edna Frasson S
authors: EF
authors: Montero
authors: Vladimir
authors: V
authors: Schraibman
authors: Ricardo B
authors: RB
authors: Benvenuto
authors: Ricardo
authors: R
authors: Artigiani Neto
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry; D009336:Necrosis; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D009994:Osmolar Concentration; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013656:Taurocholic Acid; D013997:Time Factors
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C093233:iobitridol; D007472:Iohexol; C001694:meglumine ioxithalamate; D013656:Taurocholic Acid; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D007482:Iothalamate Meglumine