title: [Laboratory evaluation of bone marrow metastasis: single institute study].
abstract: BACKGROUND
  The incidence of bone marrow (BM) metastasis might be related with the occurrence of malignant tumors in ethnic groups. So, we investigated the type and the frequency of metastatic tumors of BM and analyzed the clinicopathologic variables of BM metastasis.
  
  
  METHODS
  This study included 932 cases of primary malignant tumor which were requested for BM study from January 1995 to June 2006 in Chonnam National University Hospital and Chonnam National University Hwasun Hospital. Peripheral blood smears (PBS); aspirates, touch prints, and trephine biopsies of BM; and medical records including other laboratory test results were reviewed.
  
  
  RESULTS
  Overall frequency of BM metastasis was 11.9% (111/932). Primary tumors with BM involvement in children comprised neuroblastoma (74.1%), rhabdomyosarcoma (7.4%), and malignant lymphoma (7.4%). For adult patients, they consisted of malignant lymphoma (56.0%), gastrointestinal cancer (20.2%), and lung cancer (6.0%). In the case of malignant lymphoma, diffuse large cell lymphoma was the most frequent one. Laboratory findings of patients with BM metastasis commonly showed anemia and thrombocytopenia; in addition, serum LD, ALP, AST and ALT were elevated in 81.5% (75/92), 63.4% (59/93), 63.5% (61/96) and 33.3% (32/96), respectively. Leukoerythroblastosis was observed only in 19.8% (22/111) on PBS examination.
  
  
  CONCLUSIONS
  The most common non-hematopoietic metastatic tumor was neuroblastoma in children and gastrointestinal tumors in adults. Leukoerythroblastosis, anemia, and the elevation of serum LD, ALP, and AST were useful markers for the prediction of BM metastasis.
authors: Department of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Korea.
authors: Hyeong Kee
authors: HK
authors: Yun
authors: Myung Geun
authors: MG
authors: Shin
authors: Ding
authors: D
authors: Bo
authors: Da Woon
authors: DW
authors: Kim
authors: Duck
authors: D
authors: Cho
authors: Jong Hee
authors: JH
authors: Shin
authors: Soon Pal
authors: SP
authors: Suh
authors: Dong Wook
authors: DW
authors: Ryang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001856:Bone Marrow Examination; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006403:Hematologic Tests; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009447:Neuroblastoma / Q000473:pathology