title: [Hepatoprotective effect of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol].
abstract: 2-Demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol (11-DMP) produces antioxidant effect on the models of toxic hepatitis induced by paracetamol and carbon tetrachloride. The drug normalizes the lipid peroxidation (LPO) prosess in rat liver of the rat and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the rat blood, thus demonstrating hepatoprotective action.
authors: T A
authors: TA
authors: Sapozhnikova
authors: F S
authors: FS
authors: Zarudiĭ
authors: N Zh
authors: NZh
authors: Baschenko
authors: N S
authors: NS
authors: Makara
authors: R Iu
authors: RIu
authors: Khisamutdinova
authors: S F
authors: SF
authors: Gabdrakhmanova
authors: N A
authors: NA
authors: Ivanova
authors: V S
authors: VS
authors: Nazarov
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D000975:Antioxidants; D020011:Protective Agents; D016595:Misoprostol; D000082:Acetaminophen; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase