title: [Topical steroid injection for refractory oral chronic graft-versus-host disease].
abstract: The standard treatment for refractory oral chronic graft versus host disease (GVHD) has not been established. We present a case of AML accompanied by oral chronic GVHD in a 55-year-old man after allogeneic stem cell transplantation. The stomatitis of the patient was prolonged for a year and resistant to standard immunosuppressant therapy, including systemic administration of prednisolone and tacrolimus; however, local injection of 0.2% dexamethasone (0.5 mg per cm2) into the ulcerative area was drastically effective in improving refractory mucositis and mitigated a vicious cycle of mucosal damage and poor oral hygiene.
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors: Yumiko
authors: Y
authors: Ohbayashi
authors: Osamu
authors: O
authors: Imataki
authors: Ayuko
authors: A
authors: Higuchi
authors: Minoru
authors: M
authors: Miyake
authors: Yukiko
authors: Y
authors: Ohue
authors: Hiroaki
authors: H
authors: Ohnishi
mesh_terms: D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage*; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation; D013280:Stomatitis / Q000188:drug therapy*
chemical_list: D003907:Dexamethasone