Dectin-1 Fc targeting of aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis.
Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
Mattila
Polly E
PE
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Metz
Allison E
AE
Rapaka
Rekha R
RR
Bauer
Lynne D
LD
Steele
Chad
C
D000818:Animals; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D001232:Aspergillus fumigatus / Q000276:immunology* / Q000378:metabolism; D007113:Immunity, Innate; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D037181:Lectins, C-Type; D008172:Lung Diseases, Fungal / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D016676:Macrophages, Alveolar / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D047071:beta-Glucans / Q000276:immunology*; D000099181:Dectin-1
D007141:Immunoglobulin Fc Fragments; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D047071:beta-Glucans; D000099181:Dectin-1