Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention.
A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.
Matsuoka
Yoichiro
Y
Second Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, Japan. matsuoyo@takii.kmu.ac.jp
Hamaguchi
Tetsuya
T
Fukamachi
Katsumi
K
Yoshida
Midori
M
Watanabe
Gen
G
Taya
Kazuyoshi
K
Tsuda
Hiroyuki
H
Tsubura
Airo
A
D000818:Animals; D030801:Animals, Genetically Modified; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D011905:Genes, ras; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000473:pathology* / Q000517:prevention & control*; D011230:Precancerous Conditions / Q000473:pathology; D000090063:Proto-Oncogene Mas; D051381:Rats