Evidence of reciprocal connections between the dorsal raphe nucleus and the retina in the monkey Cebus apella.
Possible connections between the retina and the raphe nuclei were investigated in the monkey Cebus apella by intraocular injection of cholera toxin B subunit (CTb). CTb-positive fibers were seen in the lateral region of the dorsal raphe nucleus (DR) on the side contralateral to the injection, and a few labeled perikarya were observed in the lateral portion of the DR on the ipsilateral side. Our findings suggest that direct and reciprocal connections between the retina and DR may exist in Cebus apella. These connections might be part of an important pathway through which the light/dark cycle influences the activity and/or functional status of raphe neurons, with potential effects on a broad set of neural and behavioral circuits.
Frazão
Renata
R
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil.
Pinato
Luciana
L
da Silva
André V
AV
Britto
Luiz R G
LR
Oliveira
José A
JA
Nogueira
Maria I
MI
D000818:Animals; D002428:Cebus / Q000033:anatomy & histology*; D002772:Cholera Toxin / Q000378:metabolism; D007839:Functional Laterality; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D012160:Retina / Q000502:physiology*
D002772:Cholera Toxin