The DNA damage response: ten years after.
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. These findings have important implications for aging and cancer.
Harper
J Wade
JW
Department of Pathology, Harvard Medical School, and Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, USA. wade_harper@hms.harvard.edu
Elledge
Stephen J
SJ
D000818:Animals; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D046988:Proteasome Endopeptidase Complex; D011499:Protein Processing, Post-Translational; D025801:Ubiquitin / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism
D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D046988:Proteasome Endopeptidase Complex