title: Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
abstract: We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
authors: Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK.
authors: Emma
authors: E
authors: Jaeger
authors: Emily
authors: E
authors: Webb
authors: Kimberley
authors: K
authors: Howarth
authors: Luis
authors: L
authors: Carvajal-Carmona
authors: Andrew
authors: A
authors: Rowan
authors: Peter
authors: P
authors: Broderick
authors: Axel
authors: A
authors: Walther
authors: Sarah
authors: S
authors: Spain
authors: Alan
authors: A
authors: Pittman
authors: Zoe
authors: Z
authors: Kemp
authors: Kate
authors: K
authors: Sullivan
authors: Karl
authors: K
authors: Heinimann
authors: Steven
authors: S
authors: Lubbe
authors: Enric
authors: E
authors: Domingo
authors: Ella
authors: E
authors: Barclay
authors: Lynn
authors: L
authors: Martin
authors: Maggie
authors: M
authors: Gorman
authors: Ian
authors: I
authors: Chandler
authors: Jayaram
authors: J
authors: Vijayakrishnan
authors: Wendy
authors: W
authors: Wood
authors: Elli
authors: E
authors: Papaemmanuil
authors: Steven
authors: S
authors: Penegar
authors: Mobshra
authors: M
authors: Qureshi
authors: Susan
authors: S
authors: Farrington
authors: Albert
authors: A
authors: Tenesa
authors: Jean-Baptiste
authors: JB
authors: Cazier
authors: David
authors: D
authors: Kerr
authors: Richard
authors: R
authors: Gray
authors: Julian
authors: J
authors: Peto
authors: Malcolm
authors: M
authors: Dunlop
authors: Harry
authors: H
authors: Campbell
authors: Huw
authors: H
authors: Thomas
authors: Richard
authors: R
authors: Houlston
authors: Ian
authors: I
authors: Tomlinson
mesh_terms: D000236:Adenoma / Q000235:genetics; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002884:Chromosomes, Human, Pair 15; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007585:Jews / Q000235:genetics; D020641:Polymorphism, Single Nucleotide