title: Failure of an inactivated vaccine against porcine reproductive and respiratory syndrome to protect gilts against a heterologous challenge with PRRSV.
abstract: This study was designed to evaluate the efficacy of an inactivated vaccine based on a European-type strain of porcine reproductive and respiratory syndrome virus (PRRSV) against the reproductive form of the syndrome in breeding gilts, and any congenital disease in their piglets. Five gilts were vaccinated twice, following the manufacturer's instructions, before they were inseminated. Nine additional gilts remained unvaccinated and served as positive (five gilts) and negative (four gilts) controls. A European wild-type strain genetically divergent from the vaccine strain was used to challenge the five vaccinated and five unvaccinated positive control gilts at 90 days' gestation. The vaccination of the five seronegative gilts did not produce any clinical signs or adverse reactions. However, the vaccine failed to prevent the clinical signs associated with PRRSV infection, viraemia after the challenge and transplacental infection of their piglets. The reproductive performance of the vaccinated gilts was similar to that of the unvaccinated positive controls, and there were no statistically significant differences in most of the parameters tested. However, the preweaning mortality of the piglets born to the vaccinated gilts was significantly lower than that of the piglets born to the positive control gilts.
authors: Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain.
authors: M
authors: M
authors: Scortti
authors: C
authors: C
authors: Prieto
authors: E
authors: E
authors: Alvarez
authors: I
authors: I
authors: Simarro
authors: J M
authors: JM
authors: Castro
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D005333:Fetus / Q000821:virology; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000662:veterinary*; D019318:Porcine Reproductive and Respiratory Syndrome / Q000473:pathology / Q000517:prevention & control* / Q000635:transmission; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D011256:Pregnancy Outcome; D011897:Random Allocation; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014766:Viremia / Q000517:prevention & control / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines