title: [A case undergoing repeated anaphylactic shock after systemic administration of vinorelbine].
abstract: We here describe a 49-year-old man who suffered repeated anaphylactic shock after systemic chemotherapy with vinorelbine for stage IV left lung adenocarcinoma (S1+2). He was treated using a combination of cisplatin and weekly irinotecan (CPT-11) as the first line; however, the regimen was changed to a combination of vinorelbine (VNR) and gemcitabine (GEM) because of his progressive disease. He was admitted to our hospital for examination of the unknown cause of hypotension and loss of consciousness. The second shock occurred after eating pistachios, and the third one at cancerous pain. After pain control, the shock no longer occurred. Anaphylactic shock may show two peaks and late symptoms. In patients with a history of anaphylactic shock, we should pay attention to foods, drugs, and various stresses which might cause anaphylaxis.
authors: Dept. of Pharmacy, Kanazawa Medical University Hospital.
authors: Yoshimitsu
authors: Y
authors: Takahashi
authors: Takayoshi
authors: T
authors: Kiba
authors: Kayoko
authors: K
authors: Yamaguchi
authors: Yoshimasa
authors: Y
authors: Saitou
authors: Kouji
authors: K
authors: Nishio
authors: Masaharu
authors: M
authors: Iguch
authors: Yoshiharu
authors: Y
authors: Motoo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000707:Anaphylaxis / Q000139:chemically induced*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005512:Food Hypersensitivity / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D027927:Pistacia / Q000009:adverse effects; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D003841:Deoxycytidine; D014747:Vinblastine; D000077235:Vinorelbine; D000093542:Gemcitabine