title: Arguside A: a new cytotoxic triterpene glycoside from the sea cucumber Bohadschia argus Jaeger.
abstract: A new holostane-based triterpene glycoside, arguside A (1), was isolated from the sea cucumber Bohadschia argus, collected in the South China Sea. The structure of the new compound was elucidated by spectroscopic and mass-spectrometric analyses, in combination with chemical transformations. Compound 1 exhibited significant cytotoxicity against different human tumor cell lines, being more active towards HCT-116 cells (IC50 = 0.14 microM) than 10-hydroxycamptothecin (HCP) used as positive control.
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, PR China.
authors: Bao-Shu
authors: BS
authors: Liu
authors: Yang-Hua
authors: YH
authors: Yi
authors: Ling
authors: L
authors: Li
authors: Shi-Long
authors: SL
authors: Zhang
authors: Hua
authors: H
authors: Han
authors: Yi-Yi
authors: YY
authors: Weng
authors: Min-Xiang
authors: MX
authors: Pan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000633:toxicity*; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C526076:arguside A