In vitro capability of faropenem to select for resistant mutants of Streptococcus pneumoniae and Haemophilus influenzae.
When tested against nine strains of pneumococci and six of Haemophilus influenzae of various resistotypes, faropenem failed to select for resistant mutants after 50 days of consecutive subculture in subinhibitory concentrations. Faropenem also yielded low rates of spontaneous mutations against all organisms of both species. By comparison, resistant clones were obtained with macrolides, ketolides, and quinolones.
Kosowska-Shick
Klaudia
K
Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
Clark
Catherine
C
Credito
Kim
K
Dewasse
Bonifacio
B
Beachel
Linda
L
Ednie
Lois
L
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D006801:Humans; D048628:Ketolides / Q000494:pharmacology; D018942:Macrolides / Q000494:pharmacology; D009154:Mutation; D015363:Quinolones / Q000494:pharmacology; D012641:Selection, Genetic; D012692:Serial Passage; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D015363:Quinolones; D047090:beta-Lactams; C107057:fropenem