A study to establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy.
OBJECTIVE
To establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy.


METHODS
Cross-sectional observational study performed in the Obstetric and Gynaecology department, West Middlesex University Hospital. A single blood sample from 335 pregnant women at various gestations of pregnancy was analysed for thyroid function. FT4, fT3, TSH values at each gestation of pregnancy were calculated.


RESULTS
From the fT3, fT4 and TSH results, a 95% reference interval was calculated for each hormone for each week of pregnancy.


CONCLUSIONS
We calculated gestation-specific reference intervals for thyroid function tests throughout pregnancy to facilitate clinical management of thyroid disease in pregnancy.
Cotzias
Christina
C
West Middlesex University Hospital, Twickenham Road, Isleworth, Middlesex TW7 6AF, England, United Kingdom. christina.cotzias@wmuh.nhs.uk
Wong
Sarah-Jane
SJ
Taylor
Erica
E
Seed
Paul
P
Girling
Joanna
J
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control; D012016:Reference Values; D013960:Thyroid Function Tests / Q000592:standards*; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine