Meta-analysis of whole-genome linkage scans for intracranial aneurysm.
Genetic predisposition likely plays an important role in the development of intracranial aneurysms. We carried out a genome search meta-analysis to identified loci associated with intracranial aneurysm. We identified previous whole-genome linkage analyses by searching PUBMED. Five studies reported by separate investigators where detailed data could be obtained were included in our analysis. We synthesized the available genome-wide scan data by using a heterogeneity-based genome search meta-analyses. We identified two linkage sites on chromosomes 3 and 17 which had P-values <0.01 for association with intracranial aneurysm. Our findings confirm the association of a locus on chromosome 17 and identify a new linkage site on chromosome 3 for intracranial aneurysm. The new locus contains a number of potential gene candidates including kininogen-1 precursor, fibroblast growth factor-12 and endothelin converting enzyme 2.
Biros
Erik
E
Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, 4811 QLD, Australia.
Golledge
Jonathan
J
D016282:Aspartic Acid Endopeptidases / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods; D000072396:Endothelin-Converting Enzymes; D005346:Fibroblast Growth Factors / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D007704:Kininogens / Q000235:genetics; D008666:Metalloendopeptidases / Q000235:genetics
C108110:Fgf12 protein, mouse; D007704:Kininogens; D005346:Fibroblast Growth Factors; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; C000606924:ECE2 protein, human; C000606926:Ece2 protein, mouse; D000072396:Endothelin-Converting Enzymes