Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis.
Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.
Gori
Andrea
A
Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano-Bicocca, Via Solferino 16-20052, Milan, Italy. andrea.gori@unimib.it
Tincati
Camilla
C
Rizzardini
Giuliano
G
Torti
Carlo
C
Quirino
Tiziana
T
Haarman
Monique
M
Ben Amor
Kaouther
K
van Schaik
Jacqueline
J
Vriesema
Aldwin
A
Knol
Jan
J
Marchetti
Giulia
G
Welling
Gjalt
G
Clerici
Mario
M
D005243:Feces / Q000737:chemistry / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis
D039841:Leukocyte L1 Antigen Complex