title: A total synthesis of OSW-1.
abstract: A new and practical method was developed to synthesize OSW-1, a natural saponin with potent antitumor activities, from (+)-dehydroisoandrosterone, l-arabinose, and D-xylose on gram scale. The synthesis was achieved in 10 linear steps with an overall yield of 6.4% starting from (+)-dehydroisoandrosterone.
authors: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA.
authors: Jie
authors: J
authors: Xue
authors: Peng
authors: P
authors: Liu
authors: Yanbin
authors: Y
authors: Pan
authors: Zhongwu
authors: Z
authors: Guo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D002783:Cholestenones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D031442:Ornithogalum; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D012503:Saponins; C106408:OSW 1