title: New-onset anxiety disorders at high altitude.
abstract: OBJECTIVE
  Studies on the neurologic effects of high-altitude travel have focused on psychometric and cognitive testing and the long-term effects of hypoxia on memory and cognition. Few authors have discussed overt clinical psychiatric illness during high-altitude travel, and those few have focused on patients with preexisting psychiatric diagnoses. We describe a series of patients with new-onset anxiety disorders at high altitude treated at the Himalayan Rescue Association (HRA) clinic in Pheriche, Nepal (4240 m) in the spring season of 2006.
  
  
  METHODS
  We report on all 6 cases of anxiety-related illness diagnosed at the HRA Pheriche Clinic during the spring season, 2006. Three cases, representing the 3 discrete types of illness we encountered, are described in detail.
  
  
  RESULTS
  Six of 76 foreign patients and none of the 224 Nepalis seen during the season had anxiety-related primary diagnoses. None of the 6 patients had a history of psychiatric disorders or anxiety-related problems at low altitude. Three of the 6 patients were seen after hours, and all 6 required multiple visits. We describe 3 types of anxiety-related disorders: limited-symptom panic attacks induced by nocturnal periodic breathing, excessive health-related anxiety, and excessive emotionality.
  
  
  CONCLUSIONS
  Anxiety-related illness requires significant use of medical resources by high-altitude travelers. Further research is needed to define the epidemiology of anxiety-related disorders at high altitude, to quantify the contributions of various etiologic factors, and to identify safe, effective treatments.
authors: Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02140, USA.
authors: Peter J
authors: PJ
authors: Fagenholz
authors: Alice F
authors: AF
authors: Murray
authors: Jonathan A
authors: JA
authors: Gutman
authors: John K
authors: JK
authors: Findley
authors: N Stuart
authors: NS
authors: Harris
mesh_terms: D000328:Adult; D000531:Altitude; D001008:Anxiety Disorders / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering / Q000523:psychology*; D012720:Severity of Illness Index