title: Initial beam size study for passive scatter proton therapy. II. Changes in delivered depth dose profiles.
abstract: In passively scattered proton radiotherapy, a clinically useful treatment beam is produced by spreading a small proton "pencil beam" extracted from the accelerator to create both a uniform dose profile laterally and a uniform spread-out Bragg peak (SOBP) in depth. Lateral spreading and range modulation of the beam are accomplished using specially designed components within the treatment delivery nozzle. The purpose of this study was to determine how changes in the size of the initial proton pencil beam affect the delivery of dose with a passive scatter treatment nozzle. Monte Carlo calculations were used to study changes of the beam's in-air energy distribution at the exit of the nozzle and the central axis depth dose profiles in water resulting from changes in the incident beam size. Our results indicate that the width of the delivered SOBP decreases as the size of the initial beam increases.
authors: Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
authors: Jerimy C
authors: JC
authors: Polf
authors: Mark C
authors: MC
authors: Harvey
authors: Alfred R
authors: AR
authors: Smith
mesh_terms: D000465:Algorithms; D004867:Equipment Design; D006801:Humans; D015233:Models, Statistical; D009010:Monte Carlo Method; D016011:Normal Distribution; D010315:Particle Accelerators; D019047:Phantoms, Imaging; D017785:Photons; D011522:Protons; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000379:methods*; D012542:Scattering, Radiation
chemical_list: D011522:Protons