GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families.
We investigated the relationship of the gene for the X-linked orphan G protein-coupled receptor (GPR50) to childhood-onset mood disorders in a sample of 384 families with 468 affected children and adolescents collected in Hungary. Our choice of this gene for study was based on a previous report of an association of GPR50 with bipolar disorder and major depressive disorder. A significant association with the deletion allele of an insertion/deletion polymorphism (Delta502-505) located in exon 2 had been reported in a sample of 226 patients with major depressive disorder and 264 patients with bipolar disorder. The association was more significant in females compared with males in those samples. We used for this study a polymorphism in complete linkage disequilibrium with the Delta502-505 polymorphism, Thr532Ala (rs561077), and two additional polymorphisms, Val606Ile (rs13440581) and an intronic polymorphism (rs2072621). We found no evidence for an association for the markers analyzed individually, nor for haplotypes of these markers. Further, we found no evidence of association when the results were analyzed in girls only (n=215). We, therefore, failed to replicate the previous association of this gene with mood disorders.
Feng
Yu
Y
Toronto Western Research Institute, University Health Network, Ontario, Canada.
Wigg
Karen
K
King
Nicole
N
Vetró
Agnes
A
Kiss
Eniko
E
Kapornai
Krisztina
K
Mayer
László
L
Gádoros
Júlia
J
Kennedy
James L
JL
Kovacs
Maria
M
Barr
Cathy L
CL
D017668:Age of Onset; D019943:Amino Acid Substitution; D002648:Child; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X; D003866:Depressive Disorder / Q000235:genetics; D005091:Exons; D005260:Female; D006801:Humans; D006814:Hungary; D015810:Linkage Disequilibrium; D008297:Male; D019964:Mood Disorders / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion; D012727:Sex Characteristics; D044465:White People / Q000235:genetics
C509754:GPR50 protein, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled