title: Terpenoids and phenolics from Plectranthus strigosus, bioactivity screening.
abstract: Further studies on Plectranthus sp. (Lamiaceae) led to the isolation of terpenes and phenol esters from Plectranthus strigosus Benth. ent-16-Kauren-19-ol (1), ent-16-kauren-19-oic acid (2), xylopic acid (3), xylopinic acid (4), hinokiol (5), 4 beta,6 beta-dihydroxy-1 alpha,5 beta(H)-guai-9-ene (6) 4 beta,6 beta-dihydroxy-1 alpha,5 beta(H)-guai-10(14)-ene (7), mixtures of hexacosan-1,26-diol and octacosan-1,28-diol ferulate diesters (8), of esters from ferulic acid and fatty alcohols (9) and of esters from fatty acids and 2-(4-hydroxyphenyl)-ethanol (10) were for the first time isolated from this genus. Supplementary spectral data for 3,8 and parvifloron D (11) metabolites are also presented. A bioactivity study revealed herpetic inhibitory properties for (1) and (2), and antioxidant ability for (5) and (8) phenolic constituents.
authors: CECF, Faculdade de Farmácia da Universidade de Lisboa, 1649-003 Lisboa, Portugal.
authors: Cristina
authors: C
authors: Gaspar-Marques
authors: M Fátima
authors: MF
authors: Simões
authors: M Luísa
authors: ML
authors: Valdeira
authors: Benjamín
authors: B
authors: Rodríguez
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000502:physiology; D006801:Humans; D006834:Hydrazines / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031346:Plectranthus / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D045784:Abietanes; D000975:Antioxidants; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D045786:Diterpenes, Kaurane; D006834:Hydrazines; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D013729:Terpenes; C004931:1,1-diphenyl-2-picrylhydrazyl