NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)?
Previous studies have demonstrated an inverse correlation between the degree of respiratory drive and NHE3 mRNA expression in the brainstem of awake rabbits. Here we show that the levels of NHE3 mRNA extractable from kryo-conserved tissue are highly variable also in the human brainstem. As an insufficient drive to breath may be a final event causing sudden infant death, we compared the expression of NHE3 mRNA in a collective of children who died from non-natural causes to an equal number of SIDS victims. Evaluation of signals from NHE3 RT-PCR showed higher values for the SIDS collective than for the control group. We suggest that the level of NHE3 expression in brainstem tissue may contribute to the vulnerability of infants for SIDS.
Wiemann
Martin
M
University of Duisburg-Essen, Department of Physiology. martin.wiemann@uni-due.de
Frede
Stilla
S
Tschentscher
Frank
F
Kiwull-Schöne
Heidrun
H
Kiwull
Peter
P
Bingmann
Dieter
D
Brinkmann
Bernd
B
Bajanowski
Thomas
T
D000368:Aged; D001344:Autopsy; D001933:Brain Stem / Q000503:physiopathology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007223:Infant; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D012016:Reference Values; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics*; D013398:Sudden Infant Death / Q000235:genetics*
D012333:RNA, Messenger; C000613385:SLC9A3 protein, human; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers