title: Efficacy of tolterodine in relation to different urodynamic findings of detrusor overactivity.
abstract: Aim of the study was to evaluate the efficacy of tolterodine in relation to different urodynamic findings of detrusor overactivity (DO). Women with urodynamic diagnosis of DO were prospectively included into two groups: with involuntary detrusor contractions during the cystometric filling phase (group 1) or after provocative manoeuvres (group 2). Tolterodine 4 mg ER was prescribed to all women. Drug efficacy was assessed using a 3-point scale. Women were defined responders if they were improved/cured after 3 months of therapy, and non-responders if symptoms did not change. The outcome of therapy was compared between groups. A total of 111 women were included. The groups did not differ for demographic characteristics. After 12 weeks, we found a significant difference (P = 0.0008) between groups in terms of tolterodine efficacy with a better response rate in group 1. Our study shows that tolterodine efficacy may be related to different urodynamic findings of DO.
authors: Urogynaecology Unit, University of Insubria, Del Ponte Hospital, Varese, Italy. stefanosalvatore@hotmail.com
authors: Stefano
authors: S
authors: Salvatore
authors: Maurizio
authors: M
authors: Serati
authors: G Alessandro
authors: GA
authors: Digesu
authors: Paola
authors: P
authors: Triacca
authors: Stefano
authors: S
authors: Uccella
authors: Vik
authors: V
authors: Khullar
authors: PierFrancesco
authors: P
authors: Bolis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D015992:Body Mass Index; D003408:Cresols / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011446:Prospective Studies; D000068737:Tolterodine Tartrate; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology*
chemical_list: D001559:Benzhydryl Compounds; D003408:Cresols; D018727:Muscarinic Antagonists; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate