title: Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.
abstract: We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D(1)-like receptor antagonist, but not with sulpiride, a dopaminergic D(2)-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D(1)-like receptors.
authors: Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors: Eun-Joo
authors: EJ
authors: Shin
authors: Ji Hoon
authors: JH
authors: Jeong
authors: Hyun Ji
authors: HJ
authors: Kim
authors: Choon-Gon
authors: CG
authors: Jang
authors: Kiyofumi
authors: K
authors: Yamada
authors: Toshitaka
authors: T
authors: Nabeshima
authors: Hyoung-Chun
authors: HC
authors: Kim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects*; D001552:Benzazepines / Q000494:pharmacology; D015153:Blotting, Western; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007120:Immunochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011846:Radio Waves; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D016760:Proto-Oncogene Proteins c-fos; D017447:Receptors, Dopamine D1; D013469:Sulpiride; D004298:Dopamine