title: [Impact of perioperative chemotherapy on prognosis of colorectal cancer: a report of 82 cases].
abstract: OBJECTIVE
  Recently, some scholars advocate perioperative chemotherapy for colorectal cancer. This study aimed to investigate the impact of perioperative chemotherapy on the prognosis of colorectal cancer.
  
  
  METHODS
  From Aug. 2001 to Aug. 2003, 167 patients with Dukes'B or C colorectal cancer were randomized into two groups: 82 in trial group received perioperative chemotherapy using 5-fluorouracil (5-FU), while 85 in control group received no perioperative chemotherapy. All patients received adjuvant chemotherapy of 5-FU/leucovorin regimen. The adverse events, recurrence rate and survival rate were compared between these two groups.
  
  
  RESULTS
  There was no difference in adverse events between the two groups. The overall recurrence rate was 42.5%û it was significantly lower in trial group than in control group (34.6% vs. 49.4%, P=0.038). The overall 1-, 3-, and 4-year survival rates were 97.6%, 74.7% and 61.8%û they were significantly higher in trial group than in control group (100% vs. 95.3%, 82.7% vs. 67.1%, and 69.1% vs. 54.8%, P=0.046).
  
  
  CONCLUSIONS
  Perioperative chemotherapy can improve the prognosis of colorectal cancer.
authors: Department of Gastrointestinal Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, 529030, PR China. gongzhij@21cn.com
authors: Zhi-Jun
authors: ZJ
authors: Gong
authors: Jing-Qing
authors: JQ
authors: Ren
authors: Gang
authors: G
authors: Kong
authors: Du-Ju
authors: DJ
authors: Qing
authors: Hong
authors: H
authors: Liu
authors: Yong-Quan
authors: YQ
authors: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D019990:Perioperative Care; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013280:Stomatitis / Q000139:chemically induced; D015996:Survival Rate; D055815:Young Adult
chemical_list: D002955:Leucovorin; D005472:Fluorouracil