title: 2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides.
abstract: A simple and efficient method for the preparation of pyrimidine 2'-O-hydroxyethoxymethylribonucleosides and 2'-O-hydroxypropoxymethylribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes. The effect of 2' -O-modification in the antisense and sense strands of small interference RNA was evaluated in multi-drug resistant NIH 3T3 cells.
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors: Sergey N
authors: SN
authors: Mikhailov
authors: Georgii V
authors: GV
authors: Bobkov
authors: Kyrill V
authors: KV
authors: Brilliantov
authors: Jef
authors: J
authors: Rozenski
authors: Arthur
authors: A
authors: Van Aerschot
authors: Piet
authors: P
authors: Herdewijn
authors: Michael H
authors: MH
authors: Fisher
authors: Rudolph L
authors: RL
authors: Juliano
mesh_terms: D009843:Oligoribonucleotides / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009843:Oligoribonucleotides; D011743:Pyrimidines; D012263:Ribonucleosides; D012313:RNA; C030986:pyrimidine