Synthesis of a branched locked nucleic acid (LNA) analogue.
A 3'-C-branched LNA-type bicyclic nucleoside, containing a furanose ring locked in an N-type conformation, was synthesized from a known 3-C-vinyl allofuranose derivative using a strategy relying on the condensation with the nucleobase after the introduction of the branching hydroxymethyl chain by our recently developed RuO4 based protocol. This branched LNA nucleoside has a potential as a monomer for the functionalization of LNA.
Sharma
Pawan K
PK
Department of Chemistry, Kurukshetra University, Kurukshetra, India.
Kumar
Surender
S
Nielsen
Poul
P
D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D001643:Bridged Bicyclo Compounds; D009705:Nucleosides; D009841:Oligonucleotides; C477371:locked nucleic acid