HIV dynamics and immunosenescence.
Three differential equations modelling HIV virion, and infected and uninfected immune-cell densities during acute and chronic phases of infection underlie in-vivo HIV viral dynamics models. Adding a fourth equation that simulates immunosenesence through the drawdown of a stem-cell reservoir permits the phase of full-blown AIDS to be incorporated in the model. This greatly enhances the utility of the model in designing interventions and explains why time-to-full-blown AIDS decreases with age at infection.
Getz
Wayne M
WM
Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA.
D006678:HIV / Q000254:growth & development*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000821:virology; D008954:Models, Biological; D018448:Models, Immunological; D014771:Virion / Q000254:growth & development