title: Neurobiological substrates of electroconvulsive therapy for Tourette syndrome: a Serial SISCOM study.
abstract: We report the case of an adult male patient with Tourette syndrome, self-injurious behavior and depression, refractory to conventional treatment, and whose symptoms remitted after electroconvulsive therapy. Serial Technetium 99m-Ethyl-Cysteinate-Dimer single photon emission tomographies were applied, before, during, and after electroconvulsive therapy. The neural substrates of this treatment process were further analyzed by woxel-wise subtracted single photon emission tomography images.
authors: Department of Neurology, Psychiatry, and Clinical Psychology, São Paulo, Brazil.
authors: Silvio Luiz
authors: SL
authors: Morais
authors: Guilherme Nogueira
authors: GN
authors: Derenusson
authors: Joel Porfirio
authors: JP
authors: Pinto
authors: Ana Gabriela
authors: AG
authors: Hounie
authors: Serdar Murat
authors: SM
authors: Dursun
authors: Lauro
authors: L
authors: Wichert-Ana
authors: Mery
authors: M
authors: Kato
authors: Lucas Ferrari
authors: LF
authors: de Oliveira
authors: Paulo Mazzoncini
authors: PM
authors: de Azevedo-Marques
authors: Américo Ceiki
authors: AC
authors: Sakamoto
authors: Jaime Eduardo Cecílio
authors: JE
authors: Hallak
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D010054:Brief Psychiatric Rating Scale; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D003131:Combined Modality Therapy; D003545:Cysteine / Q000031:analogs & derivatives; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D015609:Organotechnetium Compounds; D011619:Psychotropic Drugs / Q000008:administration & dosage; D012039:Regional Blood Flow / Q000502:physiology; D016728:Self-Injurious Behavior / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon; D005879:Tourette Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*
chemical_list: D015609:Organotechnetium Compounds; D011619:Psychotropic Drugs; C059659:technetium Tc 99m bicisate; D003545:Cysteine