title: Interventricular septum motion abnormalities: unexpected echocardiographic changes of Brugada syndrome.
abstract: BACKGROUND
  There remains controversy about whether Brugada syndrome (BS) has structural heart changes. We occasionally noted that a patient with BS had a quite unusual regional wall motion abnormality at the basal segment of the interventricular septum (IVS) during echocardiographic examination. The unexpected finding promoted us to reexamine our patients with BS by echocardiographic interrogation in the present study.
  
  
  METHODS
  Patients with BS (n = 11), patients with complete right bundle branch block (RBBB) (n = 11), and control subjects (n = 11) were enrolled in this study. Two-dimensional echocardiography (2DE) was performed to obtain parasternal left ventricular long axis view on which M-mode scanning line was adjusted to be perpendicular to the basal segment of IVS for delineation of the segmental motion curve, with a simultaneously electrocardiographic tracing.
  
  
  RESULTS
  2DE revealed a rapid swing motion shifting toward the right ventricle of the IVS basal segment at early systole in 73% (8/11) patients with BS, which was further confirmed on the M-mode curve evidenced by an early systolic notch toward the right ventricle. The position of the notch corresponded to C-point on the mitral motion curve, lasting for (53 +/- 5) ms. There were no similar changes both in patients with RBBB and in the control subjects.
  
  
  CONCLUSIONS
  IVS basal motion abnormalities at early-systolic phase may be the novel finding of BS.
authors: Department of Cardiology, First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
authors: Zheng-rong
authors: ZR
authors: Huang
authors: Liang-long
authors: LL
authors: Chen
authors: Wei-hua
authors: WH
authors: Li
authors: Qi-zhu
authors: QZ
authors: Tang
authors: Cong-xin
authors: CX
authors: Huang
authors: Qiang
authors: Q
authors: Xie
authors: Gang
authors: G
authors: Wu
authors: Lin
authors: L
authors: Fan
mesh_terms: D000328:Adult; D000368:Aged; D053840:Brugada Syndrome / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013599:Systole; D054088:Ventricular Septum / Q000473:pathology* / Q000503:physiopathology