A seminal finding for understanding HIV transmission.
Although the worldwide incidence of HIV infection is high, the retrovirus displays a surprisingly low infectivity in vitro. As a potential explanation for this discrepancy, Münch et al. (2007) now identify and characterize a factor found in human semen that under certain conditions can enhance HIV infectivity by more than 100,000-fold.
Roan
Nadia R
NR
Gladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. nroan@gladstone.ucsf.edu
Greene
Warner C
WC
D000135:Acid Phosphatase; D000682:Amyloid / Q000502:physiology*; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D010446:Peptide Fragments / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry*; D012661:Semen / Q000378:metabolism* / Q000502:physiology; D015229:Sexually Transmitted Diseases, Viral; D019562:Viral Load
D000682:Amyloid; D010446:Peptide Fragments; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases