title: Biliary complications in right lateral sector graft live donor liver transplantation.
abstract: Biliary complications remain the most challenging issue in adult living donor liver transplantation (LDLT) and to the best of our knowledge, no study has focused on the biliary complications in LDLT with right lateral sector graft (RLSG), a graft consisting of segments VI and VII according to Couinaud's nomenclature for liver segmentation. Between January 1996 and October 2006, 310 LDLTs were performed for adult recipients at our institution. Among them, 20 patients received RLSG. The incidence of biliary complications during follow-up in these patients with RLSG was retrospectively analyzed. Follow-up period after transplantation ranged from 1 to 87 months (median 58 months). The 3-year and 5-year graft survival rates following the use of RLSGs in LDLT were 90% and 90%, respectively. Biliary complications were encountered in altogether nine patients. Two patients (10%) were complicated with bile leakage requiring surgical intervention. Seven patients (35%) were complicated with bile duct stenosis, which occurred with a median interval of 26 months (range: 6-51 months) after LDLT. Four were treated surgically and the other three were treated by endoscopic approach. Outcomes of the interventions were satisfactory in all cases. The incidence and severity of biliary complications after LDLT using RLSG was within an acceptable range with excellent graft survival. Accordingly, it is concluded that RLSG is a technically feasible option that may effectively expand the donor pool. Further application of RLSG is warranted.
authors: Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Yusuke
authors: Y
authors: Kyoden
authors: Sumihito
authors: S
authors: Tamura
authors: Yasuhiko
authors: Y
authors: Sugawara
authors: Nobuhisa
authors: N
authors: Akamatsu
authors: Yuichi
authors: Y
authors: Matsui
authors: Junichi
authors: J
authors: Togashi
authors: Junichi
authors: J
authors: Kaneko
authors: Masatoshi
authors: M
authors: Makuuchi
mesh_terms: D000328:Adult; D001649:Bile Duct Diseases / Q000453:epidemiology* / Q000209:etiology; D001652:Bile Ducts / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D019737:Transplants; D016896:Treatment Outcome