Splenic infarction due to concomitant hereditary spherocytosis and sickle cell trait.
Concomitant hereditary spherocytosis and sickle cell trait, although extremely rare, could potentially lead to splenic sequestration or infarction. We report here the first case of splenic infarction in a child with hereditary spherocytosis and sickle cell trait while flying on a commercial aircraft. The presence of hypoxia, hemoconcentrated erythrocytes, and sickle hemoglobin created the perfect environment for clinical sequelae.
Dulman
Robin Yates
RY
Department of Pediatric Hematology/Oncology, NYU School of Medicine, New York, NY 10016, USA. yatesr01@med.nyu.edu
Buchanan
George R
GR
Ginsburg
Howard
H
Fefferman
Nancy R
NR
Greco
M Alba
MA
Borys
Dariusz
D
Blei
Francine
F
D001707:Biopsy, Needle; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D018570:Risk Assessment; D012720:Severity of Illness Index; D012805:Sickle Cell Trait / Q000150:complications* / Q000175:diagnosis; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000175:diagnosis; D013156:Splenectomy / Q000379:methods; D013159:Splenic Infarction / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome