title: Evaluation of lactam protection for synthesis of 2'-O-alkylated uridines.
abstract: Two different classes of protection for the uridine lactam function have been evaluated. These are benzoyl protections and different acetal functions. In particular the triisopropylsiloxymethyl protection is a most promising lactam protecting group for use in synthesis of 2'-O-alkyl-uridines.
authors: Department of Biosciences and Nutrition, Karolinska Institutet, NOVUM, S-14157 Huddinge, Sweden.
authors: Stefan
authors: S
authors: Milton
authors: Roger
authors: R
authors: Strömberg
mesh_terms: D000478:Alkylation; D007769:Lactams / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives*
chemical_list: D007769:Lactams; D009841:Oligonucleotides; D011741:Pyrimidine Nucleosides; D014529:Uridine