Pumping up the synapse.
Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role for the KCC2 pump, also responsible for the GABAergic synapse developmental switch, in regulating spiny excitatory synapse maturation, implicating it in the coordinated maturation of inhibitory and excitatory synapses.
Penzes
Peter
P
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. p-penzes@northwestern.edu <p-penzes@northwestern.edu>
D000818:Animals; D008954:Models, Biological; D027981:Symporters / Q000172:deficiency / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D000096922:K Cl- Cotransporters
D027981:Symporters; D000096922:K Cl- Cotransporters