Synthesis and characterization of novel biodegradable poly(carbonate ester)s with photolabile protecting groups.
Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-MCC)) was obtained by UV irradiation of poly(L-lactide acid-co-5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one) (P(LA-co-MNC)) to remove the protective 2-nitrobenzyl group. The free carboxyl groups on the copolymers P(LA-co-MCC) were reacted with paclitaxel, a common antitumor drug. Gel permeation chromatography and NMR studies confirmed the copolymer structures and successful attachment of paclitaxel to the copolymer.
Xie
Zhigang
Z
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, People's Republic of China,.
Hu
Xiuli
X
Chen
Xuesi
X
Sun
Jing
J
Shi
Quan
Q
Jing
Xiabin
X
D002254:Carbonates / Q000138:chemical synthesis*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry
D002254:Carbonates; D004952:Esters