Topical tacrolimus plus oral alcohol: skin irritation.
(1) In clinical trials of topical tacrolimus (an immunosuppressant), transient skin irritation, usually at the site of application, occurred in about 0.5% to 1.3% of adult patients who had also ingested ethyl alcohol. This adverse effect has also been observed with topical pimecrolimus, a related drug. (2) Three paediatric cases have also been published. The alcohol they ingested was one of the excipients of an oral drug. (3) If skin irritation occurs at the application site for topical tacrolimus, the role of ethyl alcohol, which may have been used as an excipient for a co-administered oral drug, should be borne in mind.
D000328:Adult; D002648:Child; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D000431:Ethanol / Q000009:adverse effects*; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D000431:Ethanol; D016559:Tacrolimus