title: A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates.
abstract: We describe the preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha-or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.
authors: Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonossov Moscow State University, Moscow, Russia.
authors: Eugenia V
authors: EV
authors: Kazanova
authors: Eugeny M
authors: EM
authors: Zubin
authors: Anna V
authors: AV
authors: Kachalova
authors: Eugeny M
authors: EM
authors: Volkov
authors: Tatiana S
authors: TS
authors: Oretskaya
authors: Dmitry A
authors: DA
authors: Stetsenko
authors: Marina B
authors: MB
authors: Gottikh
mesh_terms: D005492:Folic Acid / Q000032:analysis / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides; D005492:Folic Acid