title: PAM-microfabricated polyurethane scaffolds: in vivo and in vitro preliminary studies.
abstract: Polymeric scaffolds were realised with linear degradable PU in the form of square, hexagonal and octagonal grids. They were characterised in terms of their mechanical properties. Analysis shows that the mechanical properties of the scaffolds depend on their geometries which are easily modulated using PAM. In vitro biological assays showed that PU promotes the adhesion and proliferation of fibroblast cells and that cell activities are better on PU scaffolds than on PU films. In vivo implantation of PU and PLGA scaffolds and PU films demonstrated that the scaffolds are completely resorbed after three months with a slight inflammatory response, while the PU film was still present after six months with an intense granulomatous reaction.
authors: Department of Chemical Engineering, Industrial Chemistry and Science of Materials, Interdepartmental Research Center E. Piaggio, Faculty of Engineering, University of Pisa, Via Diotisalvi 2, Pisa, Italy. g.vozzi@ing.unipi.it
authors: Giovanni
authors: G
authors: Vozzi
authors: Alfonsina
authors: A
authors: Rechichi
authors: Francesca
authors: F
authors: Dini
authors: Claudia
authors: C
authors: Salvadori
authors: Federico
authors: F
authors: Vozzi
authors: Silvia
authors: S
authors: Burchielli
authors: Fabio
authors: F
authors: Carlucci
authors: Mario
authors: M
authors: Arispici
authors: Gianluca
authors: G
authors: Ciardelli
authors: Paolo
authors: P
authors: Giusti
authors: Arti
authors: A
authors: Ahluwalia
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013594:Syringes; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011140:Polyurethanes