Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report.
We report the successful outcome of intracytoplasmic sperm injection (ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.
Dirican
Enver K
EK
Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey. kerem@dirican.tr.tc
Isik
Ahmet
A
Vicdan
Kubilay
K
Sozen
Eran
E
Suludere
Zekiye
Z
D000177:Acrosome; D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology* / Q000628:therapy*; D050498:Live Birth; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D013077:Sperm Head / Q000648:ultrastructure; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure; D016896:Treatment Outcome