[Composite herbal medicine paradon--modulator of apoptosis induced by nitrogen-oxygen stress].
Apoptosis is a mechanism that regulates the quantity and the quality of cells and provides the maintenance of body homeostasis. Disregularion of apoptosis may result in severe diseases. In this regard there is an urgent need in medicine, which modulates apoptosis. The purpose of the present research was to study the effect of composite herbal medicine Paradon on the intensity of apoptosis induced by nitrogen-oxygen stress. The research has been conducted on the intensively proliferating leukemia - transformed T cells (Jurkat cells). Medicinal preparation Paradon revealed proliferative - stimulating effect, antioxidant effect on Jurkat cells, incubated with oxygen and nitrogen free radical donors (hydrogen peroxide (Sigma) and sodium nitroprusside (Naniprus, Sopharma)). Paradon - through the recovery of energoproducing system activity reduces the intensity of necrosis, induced by nitrogen-oxygen stress, and replaces it with more mild mechanism of cell death - apoptosis.
Kvatadze
N
N
Institute of Medical Biotechnology.
Machavariani
M
M
McHedlishvili
T
T
Datunashvili
I
I
Sanikidze
T
T
D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019169:Jurkat Cells; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D020030:Nitric Oxide Donors; D009589:Nitrogen Oxides; D010936:Plant Extracts; D009599:Nitroprusside; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase