title: Original article: New surgical approaches to the Klatskin tumour.
abstract: BACKGROUND
  Surgical treatment of hilar cholangiocarcinoma (Klatskin tumours) is difficult because of its central location in the liver hilum. Recent developments in surgical techniques have improved the outcome after resection.
  
  
  OBJECTIVE
  To describe the surgical approaches currently applied in our centre and the impact of these strategies on outcome and criteria for resection.
  
  
  METHODS
  From 1988 to 2003, 99 consecutive patients underwent resection for hilar cholangiocarcinoma. Patients were analysed for rate of R0 resections in relation with Bismuth classification. Morbidity, mortality and survival were assessed.
  
  
  RESULTS
  The rate of hilar resections in combination with (extended) liver resections for type III and IV tumours increased from 24% to 95% in the last 5 years of the study period. Eight patients (8%) had Bismuth type IV tumours. Four of these patients underwent palliative local excisions of the hepatic duct confluence whereas the other four patients underwent hilar resection in combination with partial liver resection, resulting in microscopically radical resections. There was no mortality in this group. Overall postoperative morbidity and mortality were 68% and 10%, respectively.
  
  
  CONCLUSIONS
  An aggressive surgical approach consisting of hilar resections combined with partial liver resections including segments 1 and 4, resulted in a higher rate of R0 resections. Even Bismuth type IV tumours may be resectable depending on the biliary anatomy of the hepatic duct confluence.
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. t.m.vangulik@amc.uva.nl
authors: T M
authors: TM
authors: Van Gulik
authors: S
authors: S
authors: Dinant
authors: O R C
authors: OR
authors: Busch
authors: E A J
authors: EA
authors: Rauws
authors: H
authors: H
authors: Obertop
authors: D J
authors: DJ
authors: Gouma
mesh_terms: D001650:Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery*; D002761:Cholangitis / Q000401:mortality / Q000601:surgery*; D006500:Hepatic Duct, Common / Q000601:surgery*; D006801:Humans; D018285:Klatskin Tumor / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome