Synthesis of a 2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate building block and a model dinucleotide.
In order to obtain higher quality 2'-O-carbamoylmethyl oligoribonucleotides we are conducting studies of this modification. Here we present synthesis of 2'-O-carbamoylmethyl containing H-phosphonate building blocks as well as synthesis of model dinucleotides needed for these studies.
Milton
Stefan
S
Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-14157 Huddinge, Sweden.
Yeheskiely
Raunak Esther
RE
Strömberg
Roger
R
D009843:Oligoribonucleotides / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D012263:Ribonucleosides / Q000138:chemical synthesis / Q000737:chemistry*
C527151:2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate; D009843:Oligoribonucleotides; D063065:Organophosphonates; D012263:Ribonucleosides