[Daptomycin: revitalizing a former drug due to the need of new active agents against grampositive multiresistant bacterias].
The development of mechanisms of resistance of many Gram-positive bacterial strains that cause complicated skin and soft tissue infections, as well as sepsis and bacteremia, has necessitated the search for new drugs that will improve treatment strategies. Daptomycin is a cyclic lipopeptide antibacterial that was launched for the treatment of complicated skin and soft tissue infections caused by Gram-positive organisms. The drug's mechanism of action is different from that of any other antibiotic. It binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA and RNA synthesis, which results in bacterial cell death. The in vitro spectrum of activity of daptomycin encompasses most clinically relevant aerobic Gram-positive pathogenic bacteria. Compared to other antibiotics with a similar antibacterial spectrum, daptomycin does not cause nephrotoxicity. Taking these and other characteristics into consideration, daptomycin appears to be a good alternative to other drugs used in the treatment of complicated skin and soft tissue infections and in Gram-positive bacteremial infections.
Hernández Martí
V
V
Servicio de Farmacia, Hospital Universitario La Fe, Valencia.
Romá Sánchez
E
E
Salavert Lletí
M
M
Bosó Ribelles
V
V
Poveda Andrés
J L
JL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D002462:Cell Membrane / Q000187:drug effects; D017576:Daptomycin / Q000009:adverse effects / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016527:Drug Costs; D004353:Drug Evaluation, Preclinical; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000502:physiology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D017576:Daptomycin