title: Basement membrane-like substance in cytologic diagnosis in clear cell adenocarcinoma of the minor salivary gland of the palate. A case report.
abstract: BACKGROUND
  Clear cell adenocarcinoma (CCA) of the minor salivary gland accounts for < 1% of all tumors of the salivary gland.
  
  
  METHODS
  A 32-year-old woman with a history of papillary carcinoma of the thyroid 1 year earlier complained of pain on the left side of the neck. After a detailed examination, the patient underwent the resection of a tumor located at the palate. Imprint cytology of the tumor revealed cohesive tumor cells of uniform size containing an abundant clear cytoplasm and round nuclei with extra but fine granular chromatin and conspicuous nucleoli. A basement membrane-like substance (BMS) was stained in light green with Papanicolaou staining and was positive for laminin with immunohistochemical staining. Histopathologic analysis confirmed the trabecular or nest-like arrangement of the cells with the clear cytoplasm and BMS substance surrounded by tumor cells, which were positive for laminin and AE1 immunohistochemically.
  
  
  CONCLUSIONS
  Although CCA of the palate is extremely rare, an accurate cytologic diagnosis can be made if the characteristic findings of CCA, including BMS, are imaged.
authors: Department of Clinical Cytology, School of Allied Health Sciences, Kitasato University Hospital, Kanagawa, Japan.
authors: Miho
authors: M
authors: Kobayashi
authors: Manabu
authors: M
authors: Hattori
authors: Tomoyuki
authors: T
authors: Miyamoto
authors: Hirokuni
authors: H
authors: Kakinuma
authors: Jun
authors: J
authors: Watanabe
authors: Keiichi
authors: K
authors: Iwabuchi
authors: Yukari
authors: Y
authors: Nishimura
authors: Toshiko
authors: T
authors: Jobo
authors: Hiroyuki
authors: H
authors: Kuramoto
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D003581:Cytodiagnosis / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007797:Laminin / Q000378:metabolism; D010157:Palatal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012470:Salivary Glands, Minor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D007797:Laminin