[Experimental evaluation of the antiulcer activity of calcium pectate].
Both chronic (prophylactic) and single administration of standardized calcium pectate considerably increased the resistance of rat stomach mucous membrane with respect to ulcerogenic factors of various etiology, including immobilized stress, indomethacin, ethanol, prednizolone, and histamine, according to H. Shay's model. The gastroprotective effect of this polysaccharide was comparable with or exceeded the action of famotidine, sea buckthorn oil, and maalox.
Krylova
S G
SG
Efimova
L A
LA
Zueva
E P
EP
Khotimchenko
M Iu
MIu
Razina
T G
TG
Amosova
E N
EN
Lopatina
K A
KA
Khotimchenko
Iu S
IuS
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D010368:Pectins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010368:Pectins; C003181:polygalacturonic acid