Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds.
The reactions of arene-metal complexes (arene=p-cymene, benzene or pentamethylcyclopentadienyl, metal=Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(eta5-C10H15)RhCl(pta-Me)2]Cl2, [(eta6-C10H14)OsCl(pta)2]Cl, and [(eta6-C6H6)OsCl2(CH3CN)], are also reported.
Dorcier
Antoine
A
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH-1015 Lausanne, Switzerland.
Hartinger
Christian G
CG
Scopelliti
Rosario
R
Fish
Richard H
RH
Keppler
Bernhard K
BK
Dyson
Paul J
PJ
D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry*; D011684:Purine Nucleosides / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D009942:Organometallic Compounds; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D009992:Osmium; D012211:Rhenium; D012428:Ruthenium; D004247:DNA