TAMpering with toll-like receptor signaling.
Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.
O'Neill
Luke A J
LA
School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. laoneill@tcd.ie
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D003713:Dendritic Cells / Q000378:metabolism; D007249:Inflammation / Q000517:prevention & control; D051379:Mice; D018345:Mice, Knockout; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism; D051193:Toll-Like Receptors / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; C491590:Socs1 protein, mouse; C491411:Socs3 protein, mouse; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D051193:Toll-Like Receptors; D020794:Receptor Protein-Tyrosine Kinases