title: Reported symptoms of food hypersensitivity and sensitization to common foods in 4-year-old children.
abstract: OBJECTIVE
  To characterize reported food hypersensitivity (FHS) among young children in a birth cohort.
  
  
  METHODS
  At 4 years of age a parental questionnaire on FHS and allergic symptoms was evaluated. Blood was collected for analyses of IgE-antibodies to egg, milk, fish, wheat, peanut and soy. Complete questionnaire data was available for 3694 children (90%), and blood samples were obtained from 2563 children (63%).
  
  
  RESULTS
  FHS was reported in 11% of the children (n=397). Eczema was the most commonly reported symptom and the only symptom in half of these children. Food-related reactions from the airways, facial oedema or urticaria were reported in 198 children, and the majority of these children (75%) reported multiple symptoms. Furthermore, a combination of airway symptoms, facial oedema or urticaria together with sensitization to food suggested a more severe form of FHS. This was found in 1.6% of all children. Symptoms caused by peanut were closely associated with sensitization to peanut (p<0.001).
  
  
  CONCLUSIONS
  FHS in 4-year-old children with any of asthma, rhino-conjunctivitis, facial oedema or urticaria in combination is in most cases associated to sensitization to food. This phenotype of FHS is likely to represent a more severe form of FHS.
authors: Department of Pediatrics', Sachs' Children's Hospital, Stockholm, Sweden. eva.ostblom@ki.se
authors: Eva
authors: E
authors: Ostblom
authors: Magnus
authors: M
authors: Wickman
authors: Marianne
authors: M
authors: van Hage
authors: Gunnar
authors: G
authors: Lilja
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D011795:Surveys and Questionnaires
chemical_list: D007073:Immunoglobulin E