title: Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice.
abstract: A recent hypothesis suggests that there is impaired hippocampal neurogenesis in Alzheimer's disease. Here we examined the proliferation, the first stage in neurogenesis, of hippocampal progenitor cells in amyloid precursor protein with Swedish mutation and presenilin-1 with deletion of exon 9 (APPswe/PS1dE9) transgenic mice. Compared with age-matched wild-type mice, transgenic mice at 5 months of age with low amyloid beta-peptide (Abeta) levels and subtle Abeta deposits showed normal proliferation of hippocampal progenitor cells; however, transgenic mice at 9 months of age with high Abeta levels and numerous Abeta deposits showed decreased proliferation of these cells. The number of proliferating cells in male transgenic mice was indistinguishable from that in female transgenic mice. These results indicate that neurogenesis is decreased with degrees of Abeta pathology, and that there is no gender difference in their proliferation in APPswe/PS1dE9 transgenic mice.
authors: Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
authors: Nobuhiko
authors: N
authors: Taniuchi
authors: Tetsuhiro
authors: T
authors: Niidome
authors: Yasuaki
authors: Y
authors: Goto
authors: Akinori
authors: A
authors: Akaike
authors: Takeshi
authors: T
authors: Kihara
authors: Hachiro
authors: H
authors: Sugimoto
mesh_terms: D016229:Amyloid beta-Peptides / Q000235:genetics / Q000502:physiology; D000686:Amyloidosis / Q000473:pathology; D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D049109:Cell Proliferation; D005091:Exons / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006624:Hippocampus / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000235:genetics* / Q000502:physiology*; D012727:Sex Characteristics; D013234:Stem Cells / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D000963:Antimetabolites; D053764:Presenilin-1; D001973:Bromodeoxyuridine