title: Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants.
abstract: Acute bronchiolitis is the main cause of emergency visits and hospitalizations in infants. Recent data suggest that neutrophil- and eosinophil-mediated inflammations were part of bronchiolitis pathophysiology. Apart from the defined risk factors, few was known on the underlying pathophysiology, which might point out the differences observed in the severity of the disease. The aim of this study was to assess whether the clinical severity of acute epidemic bronchiolitis in young infants might be related to a specific underlying inflammatory process. Total and differential cell counts, IL-8, eotaxin, eosinophil cationic protein (ECP) and albumin levels were assessed at the time of admission in bronchial secretions from 37 infants (median age 17 wk) with acute bronchiolitis. Outcome severity variables were: hypoxemia, Silverman score, tachypnea, feeding alteration, and duration of hospitalization. Neutrophils predominated, and eosinophils were present in 54% of the infants. IL-8 levels strongly correlated with ECP and albumin levels. Albumin levels were correlated with ECP and eotaxin levels. IL-8 levels were higher in infants with hypoxemia and inversely related with SaO(2) levels. IL-8 and albumin levels significantly rose with respiratory rate, and Silverman score. IL-8, albumin and ECP levels were significantly higher in infants hospitalized >/=7 days. Furthermore, IL-8 levels were correlated with the duration of hospitalization. Neither cell counts nor eotaxin levels were related to the severity criteria studied. This study suggests that IL-8-associated airway inflammation significantly contributed to the severity of acute epidemic bronchiolitis.
authors: Pediatric Respiratory Disease Unit, Rouen University Hospital-Charles Nicolle, Rouen cedex, France. christophe.marguet@chu-rouen.fr
authors: Christophe
authors: C
authors: Marguet
authors: Nathalie
authors: N
authors: Bocquel
authors: Jacques
authors: J
authors: Benichou
authors: Jean Pierre
authors: JP
authors: Basuyau
authors: Marie France
authors: MF
authors: Hellot
authors: Laure
authors: L
authors: Couderc
authors: Eric
authors: E
authors: Mallet
authors: Bertrand
authors: B
authors: Macé
mesh_terms: D000208:Acute Disease; D000418:Albumins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001990:Bronchiolitis, Viral / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000276:immunology; D007223:Infant; D007249:Inflammation / Q000276:immunology*; D016209:Interleukin-8 / Q000378:metabolism; D007902:Length of Stay / Q000706:statistics & numerical data; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013183:Sputum / Q000276:immunology
chemical_list: D000418:Albumins; D015415:Biomarkers; D016209:Interleukin-8