Synthesis and biophysical characterization of G-rich oligonucleotides conjugated with sugar-phosphate tails.
A number of 5'-and 3'-glycoconjugates of the oligonucleotide (5')d(TGGGAG)(3') have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by thermal denaturation studies, via a detailed CD Q1 analysis.
D'Onofrio
J
J
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Via Cintia 4, I-80126 Naples, Italy.
Erra
E
E
Di Fabio
G
G
Iadonisi
A
A
Petraccone
L
L
De Napoli
L
L
Barone
G
G
Balzarini
J
J
Giancola
C
C
Montesarchio
D
D
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry*; D006151:Guanosine / Q000235:genetics; D015497:HIV-1; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013403:Sugar Phosphates / Q000737:chemistry
D019380:Anti-HIV Agents; D006001:Glycoconjugates; D009838:Oligodeoxyribonucleotides; D013403:Sugar Phosphates; D006151:Guanosine