Studies on the radioprotective effect of etiocholanolone.
One-hundred forty male mice of an inbred strain (C3H/St) were divided into four groups of thirty-five each and were given total body irradiation of 750 cGy. After X-irradiation, one group was given etiocholanolone alone, the other was given bone marrow alone, a third was given both of these. One group was used as a control and was given no treatment after irradiation. The bone marrow used was obtained from the same inbred strain of mice. The most remarkable hematologic recovery was seen in the group which was given both etiocholanolone and bone marrow. The groups given only etiocholanolone or only bone marrow recovered better than the control group. Overall survival was best for the group receiving both modes of treatment and worst for the control group. Survival for the groups receiving a single mode of treatment lay in between the other two mentioned above.
Ambrus
Julian L
JL
Department of Medicine, State University of NY at Buffalo, Buffalo General Hospital Kaleida Health System, Buffalo, NY 14203, USA.
Ambrus
Clara M
CM
Gahwyler
Max E
ME
Akhter
Selina
S
Jankowski
Andrew
A
Lane
Warren
W
D000818:Animals; D016026:Bone Marrow Transplantation; D005043:Etiocholanolone / Q000008:administration & dosage / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016019:Survival Analysis; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D005043:Etiocholanolone