title: Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock.
abstract: BACKGROUND
  A rapid, reliable, and noninvasive functional measure of responsiveness to resuscitation in posttraumatic hemorrhagic shock could prove useful in guiding therapy, especially under circumstances such as the battlefield and civilian mass casualties. Tissue oxygen saturation (Sto2) is a promising candidate for this application. We therefore explored the value of peripheral muscle Sto2 in predicting systemic responsiveness to colloid volume resuscitation in a porcine model of hemorrhagic shock.
  
  
  METHODS
  Fourteen isoflurane-anesthetized piglets were subjected to a standardized hemorrhage protocol that maintained mean arterial pressure (MAP) between 30 and 40 mm Hg. Asanguineous resuscitation with a volume of Hextend equal to the total volume bled was initiated when compensation was exhausted (MAP <30 mm Hg). We recorded continuous MAP and Sto2 values, and calculated the contiguous area over the Sto2 curve yet below a given threshold of Sto2 (TAOC) as a function of this threshold before the selected timepoint for timepoints up to 30 minutes before resuscitation.
  
  
  RESULTS
  Hemorrhage resulted in significant fluctuations of MAP and high interindividual variability of disease dynamics and outcome: 4 nonsurvivors and 10 survivors at 2 hours postresuscitation. Sto2 measurements reflected hemodynamic conditions in most animals, with a pronounced drop preceding final decompensation in 7 of 14 animals. TAOC discriminated three of four nonresuscitable (nonsurvivor) animals from the survivors, with group differences reaching significance even for the earliest examined timepoint (30 minutes before resuscitation), depending on the choice of TAOC threshold.
  
  
  CONCLUSIONS
  Sto2 may serve as a marker of decompensation, whereas TAOC, a physiologically motivated correlate of perfusion debt and cumulative hypoperfusion injury, may be a useful early indicator of responsiveness to volume resuscitation in hemorrhagic shock.
authors: Center for Inflammation and Regenerative Modeling (CIRM), University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors: Sven
authors: S
authors: Zenker
authors: Patricio M
authors: PM
authors: Polanco
authors: Hyung Kook
authors: HK
authors: Kim
authors: Andres
authors: A
authors: Torres
authors: Yoram
authors: Y
authors: Vodovotz
authors: Gilles
authors: G
authors: Clermont
authors: Michael R
authors: MR
authors: Pinsky
authors: Donald A
authors: DA
authors: Severyn
authors: Juan Carlos
authors: JC
authors: Puyana
mesh_terms: D000818:Animals; D019540:Area Under Curve; D006439:Hemodynamics; D010100:Oxygen / Q000378:metabolism*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000628:therapy*; D013057:Spectrum Analysis / Q000379:methods; D018709:Statistics, Nonparametric; D013552:Swine
chemical_list: D010100:Oxygen