The evaluation of protein structure prediction results.
Methods for protein structure prediction are flourishing and becoming widely available to both experimentalists and computational biologists. However, how good are they? What is their range of applicability and how can we know which method is better suited for the task at hand? These are the questions that this review tries to address, by describing the worldwide Critical Assessment of techniques for protein Structure Prediction (CASP) initiative and focusing on the specific problems of assessing the quality of a protein 3D model.
Cozzetto
Domenico
D
Department of Biochemical Sciences Rossi Fanelli, University of Rome La Sapienza, P. le A. Moro, 5, 00185, Rome, Italy.
Giorgetti
Alejandro
A
Raimondo
Domenico
D
Tramontano
Anna
A
D019295:Computational Biology / Q000379:methods*; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D012680:Sensitivity and Specificity
D011506:Proteins