The serial changes of ghrelin and leptin levels and their relations to weight loss after laparoscopic minigastric bypass surgery.
BACKGROUND
The ghrelin and leptin levels have been reported to be correlated with weight loss after bariatric surgery. However, the serial changes of ghrelin and leptin levels after laparoscopic minigastric bypass surgery (LMGBP) have not been reported yet. Therefore, we aimed to evaluate their serial changes and to analyze their relations to weight reduction after LMGBP.


METHODS
Serial fasting serum leptin and ghrelin concentrations were measured in 68 morbidly obese patients before (M0) and 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months after LMGBP surgery. The correlations between ghrelin, insulin, and leptin concentrations and weight reduction were analyzed.


RESULTS
Leptin levels were significantly reduced at 1, 3, 6, and 12 months after surgery, respectively (vs M0, p < 0.001), whereas the ghrelin concentrations were not significantly changed after surgery. The percent of excess BMI lost (%EBL) 12 months after surgery was negatively correlated with higher preoperative ghrelin concentrations (p = 0.004) and larger preoperative BMI (p = 0.002) in the multivariate analysis.


CONCLUSIONS
Higher preoperative ghrelin concentrations and larger BMI are predictive of less %EBL at 12 months after LMGBP surgery.
Liou
Jyh-Ming
JM
Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei, Taiwan.
Lin
Jaw-Town
JT
Lee
Wei-Jei
WJ
Wang
Hsiu-Po
HP
Lee
Yi-Chia
YC
Chiu
Han-Mo
HM
Wu
Ming-Shiang
MS
D000328:Adult; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D010535:Laparoscopy; D020738:Leptin / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D011237:Predictive Value of Tests; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
D054439:Ghrelin; D007328:Insulin; D020738:Leptin