title: Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives.
abstract: A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.
authors: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
authors: Yu-Cheng
authors: YC
authors: Chang
authors: Jayatilake
authors: J
authors: Herath
authors: Tony H-H
authors: TH
authors: Wang
authors: Christine S
authors: CS
authors: Chow
mesh_terms: D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014529:Uridine