Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males.
Opiate addiction is a chronic disorder characterized by relapse behaviour, often preceded by craving and anhedonia. Chronic craving and anhedonia have been associated with low availability of dopamine D2 receptors (D2Rs) and cue-elicited craving has been linked with endogenous dopamine release. We studied D2R availability and cue-elicited endogenous dopamine release in 12 abstinent opiate-dependent males and 18 age-matched male controls with [123I]IBZM SPECT. Craving was manipulated with a video containing heroin-related stimuli. Moreover, chronic craving, anhedonia and cue-elicited craving were measured. We found lower baseline D2R availability in opiate-dependent subjects than controls in the left caudate nucleus. D2R availability in the putamen correlated negatively with years of opiate use. Opiate-dependent subjects demonstrated higher dopamine release after cue-exposure in the right putamen than controls. Chronic craving and anhedonia were positively correlated with DA release. Treatment strategies that increase D2Rs may, therefore, be an interesting approach to prevent relapse in opiate addiction.
Zijlstra
Fleur
F
Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Booij
Jan
J
van den Brink
Wim
W
Franken
Ingmar H A
IH
D000328:Adult; D001549:Benzamides; D003463:Cues; D003627:Data Interpretation, Statistical; D004298:Dopamine / Q000378:metabolism*; D006556:Heroin Dependence / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D011759:Pyrrolidines; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012907:Smoking / Q000523:psychology; D015813:Substance Abuse Detection; D013375:Substance Withdrawal Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
D001549:Benzamides; D011759:Pyrrolidines; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide; D004298:Dopamine