title: Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study.
abstract: Serotonergic dysfunction appears to be involved in the pathogenesis of schizophrenia. The loudness dependence of auditory evoked potentials (LDAEP) has been suggested to be a valid indicator of the brain serotonin system's activity in humans. Patients with schizophrenia showed weaker LDAEP, indicating high serotonergic activity, in comparison to healthy controls. Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia.
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany. george.juckel@wkp-lwl.org
authors: Georg
authors: G
authors: Juckel
authors: Yehonala
authors: Y
authors: Gudlowski
authors: Dirk
authors: D
authors: Müller
authors: Seza
authors: S
authors: Ozgürdal
authors: Martin
authors: M
authors: Brüne
authors: Jürgen
authors: J
authors: Gallinat
authors: Thomas
authors: T
authors: Frodl
authors: Henning
authors: H
authors: Witthaus
authors: Idun
authors: I
authors: Uhl
authors: Alexander
authors: A
authors: Wutzler
authors: Oliver
authors: O
authors: Pogarell
authors: Christoph
authors: C
authors: Mulert
authors: Ulrich
authors: U
authors: Hegerl
authors: Eva-Maria
authors: EM
authors: Meisenzahl
mesh_terms: D000328:Adult; D010054:Brief Psychiatric Rating Scale; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008144:Loudness Perception / Q000502:physiology*; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000502:physiology*; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D012701:Serotonin