[Effect of taurine on the pool of central neuroactive compounds during ethanol withdrawal syndrome].
Influence of taurine on the pool of central neuroactive compounds during alcohol withdrawal syndrome has been investigated. Alcohol withdrawal syndrome was accompanied by a pronounced dysbalance in the formation of the pool of neuroactive compounds. The most remarkable changes were found in the levels of markers related to the central serotoninergic system, as well as dopaminergic system. Taurine administration in a dose of 650 mg/kg (i.g.) one hour before decapitation during ethanol withdrawal syndrome alleviates disturbances in the functioning of serotoninergic and (to a lesser extent) dopaminergic systems and improves the ratio of inhibitory and excitatory mediator amino acids.
Razvdovskiĭ
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IuE
Doroshenko
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D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000378:metabolism* / Q000517:prevention & control; D013654:Taurine / Q000494:pharmacology*
D000596:Amino Acids; D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D013654:Taurine; D000431:Ethanol