[Pediatric glioblastoma: a clinicopathological study of 12 cases with p53 protein immunohistochemistry].
Glioblastoma is one of the most lethal central nervous system (CNS) primary tumors. Although significant progress, only few analysis have been made in pediatric glioblastoma, which are less common and have worse prognosis than in adults. To evaluate gender, site, age, survival, and immunohistochemistry to p53, we selected cases of pediatric glioblastoma of "CNS Tumors Database in Curitiba", 1987-2003 and of the Hospital Municipal Jesus, Rio de Janeiro, 1970-1988. Twelve tumors were included. The age ranged from up to 12 years (median 7). There were 7 females and 5 males. The median survival was 7.9 months. Location was: cerebral hemispheres (58.4%), mesencephalon and brainstem (33.3%) and one case in the cerebellum. Immunostained to p53 in 9 (75%) cases. In conclusion, glioblastoma behaves similarly in children and adults. It is rare in children, affects both cerebral hemispheres more than brainstem and cerebellum and shows strong immunohistochemistry to p53.
Pope
Leonora Zozula Blind
LZ
Universidade Federal do Paraná, Curitiba, PR, Brazil. leonora.pope@donahelena.com.br
Serapião
Maria José
MJ
Serapião
Carlos José
CJ
Oliveira
Maria Marcelina Silva Teive
MM
Benites Filho
Paulo Roberto
PR
Gugelmin
Elizabeth Scheneider
ES
Bleggi-Torres
Luiz Fernando
LF
D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53