Design and synthesis of cyclic RGD pentapeptoids by consecutive Ugi reactions.
A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The results confirm the versatility and efficiency of the method for the preparation of cyclic oligopeptoids.
Vercillo
Otilie E
OE
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
Andrade
Carlos Kleber Z
CK
Wessjohann
Ludger A
LA
D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry*
D010456:Peptides, Cyclic; D034444:Peptoids; C507169:cyclic arginine-glycine-aspartic acid peptide