The effects of FG7142 on two types of forgetting in 18-day-old rats.
The authors studied the role of gamma-aminobutyric acid (GABA) in 2 types of forgetting of fear in the developing rat. One type of forgetting studied was that observed after an intermediate retention interval (the "Kamin effect"); the other type studied was that observed after a longer interval (infantile amnesia). Rats were given pairings of an auditory conditioned stimulus with shock, and learned fear was assessed by freezing. Forgetting at an intermediate retention interval (1 hr) was not alleviated by the GABA-sub(A) receptor partial inverse agonist FG7142 (0, 1, 5, or 10 mg/kg), whereas forgetting at a longer retention interval (48 hr) was alleviated. These results suggest that in the developing rat, forgetting observed at different retention intervals is mediated by different physiological mechanisms.
Tang
Helen H Y
HH
School of Psychology, University of New South Wales, Sydney, Australia. htang@psy.unsw.edu.au
McNally
Gavan P
GP
Richardson
Rick
R
D000704:Analysis of Variance; D000818:Animals; D001067:Appetite Depressants / Q000009:adverse effects*; D001522:Behavior, Animal / Q000187:drug effects; D002243:Carbolines / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000145:classification*; D051381:Rats; D013997:Time Factors
D001067:Appetite Depressants; D002243:Carbolines; C035874:FG 7142