title: Toward an artificial aldolase.
abstract: A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water.
authors: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, E-43007 Tarragona, Spain.
authors: Daniel
authors: D
authors: Font
authors: Sonia
authors: S
authors: Sayalero
authors: Amaia
authors: A
authors: Bastero
authors: Ciril
authors: C
authors: Jimeno
authors: Miquel A
authors: MA
authors: Pericàs
mesh_terms: D005634:Fructose-Bisphosphate Aldolase / Q000138:chemical synthesis*; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D011137:Polystyrenes; D012997:Solvents; D014230:Triazoles; D014867:Water; D011392:Proline; D005634:Fructose-Bisphosphate Aldolase