[Intraepithelial lesions and neoplasia associated with human papillomavirus infection].
Anogenital lesions induced by human papillomaviruses (HPV) are due to both high-risk HPV types involved in carcinogenesis of the cervix (and also, to a lesser extent, of the vulva, anus and vagina) and to low-risk HPV types that cause external genital warts in the perianal region, perineum, vulva and vagina (less often the cervix). Cervical cancer is thus virus-induced, and there is a continuum from intraepithelial lesions to invasive cancer. This offers the opportunity to screen cervical smears for cytological abnormalities or to detect high-risk HPV infection by molecular methods. Although the causal link between human genital papillomavirus infection and cervical neoplasia is well established, the role of beta-HPV in non melanoma skin cancers is unclear.
Riethmuller
Didier
D
EA 3181, IFR 133, Université de Franche-Comté, Service de Gynécologie-Obstétrique, Hôpital St Jacques, CHU Besançon, Pavillon La mère et l'enfant, 25030 Besançon Cedex.
Guerrini
Jean-Sébastien
JS
Aubin
François
F
D000328:Adult; D001913:Bowen's Disease / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000209:etiology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology