TNF and sTNFR1/2 plasma levels in ALS patients.
The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.
Cereda
Cristina
C
Neurological Institute IRCCS "C. Mondino", Pavia, Italy. cristina.cereda@mondino.it
Baiocchi
Chiara
C
Bongioanni
Paolo
P
Cova
Emanuela
E
Guareschi
Stefania
S
Metelli
Maria Rita
MR
Rossi
Bruno
B
Sbalsi
Ilaria
I
Cuccia
Maria Clara
MC
Ceroni
Mauro
M
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000235:genetics / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012150:Polymorphism, Restriction Fragment Length; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood* / Q000235:genetics / Q000502:physiology; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood* / Q000235:genetics / Q000502:physiology; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000235:genetics / Q000502:physiology
D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha