title: [Relationship between soluble intercellular adhesion molecule-1 and severe pneumonia].
abstract: OBJECTIVE
  It has been reported that soluble intercellular adhesion molecule-1 (sICAM-1) participates in many immune and inflammatory reactions. Its expression and role in severe pneumonia has not fully been understood. This study aimed to investigate the changes of sICAM-1 expression in severe pneumonia and the relationship between sICAM-1 and severe pneumonia in children.
  
  
  METHODS
  Serum sICAM-1 levels were determined by the double antibody sand using ELISA in 50 children with severe pneumonia and 56 children with mild pneumonia. Fifty-two healthy children served as control group.
  
  
  RESULTS
  Serum sICAM-1 levels in children with severe pneumonia (402.36 +/- 31.24 mu g/L) were remarkably higher than those in the mild pneumonia group (278.86 +/- 36.24 mu g/L) at the acute stage and higher than in the control group (180.74 +/- 21.46 mu g/L) (P < 0.01). Serum sICAM-1 levels in children with severe pneumonia decreased significantly at the recovery stage (198.56 +/- 12.63 mu g/L) (P < 0.01), which were not statistically different from those in the mild pneumonia group at the recovery stage and the control group. There were no significant differences in serum sICAM-1 levels among the severe pneumonia subgroups caused by different pathogens (bacteria, virus or Mycoplasma) at the acute stage. Serum sICAM-1 levels at the acute stage in children with severe pneumonia who were treated successfully were not significantly different from those in patients whose symptoms were partly improved.
  
  
  CONCLUSIONS
  sICAM-1 might be involved in the inflammation course of severe pneumonia. It can severe as a marker of the diagnosis and the severity evaluation of severe pneumonia.
authors: Bao'an Maternal and Child Health Care Hospital, Shenzhen, Guangdong, China. chunyi8@hotmail.com
authors: Chun-Yi
authors: CY
authors: Liu
authors: Ping
authors: P
authors: Jin
authors: Yan-Xia
authors: YX
authors: Yang
authors: Hong-Xia
authors: HX
authors: Liu
authors: Ya-Qiu
authors: YQ
authors: Liu
authors: Jin-Ji
authors: JJ
authors: Xu
authors: Wei-Dong
authors: WD
authors: Huang
authors: Shi-Jun
authors: SJ
authors: Wang
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D011014:Pneumonia / Q000097:blood*; D011379:Prognosis
chemical_list: D018799:Intercellular Adhesion Molecule-1