title: Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction.
abstract: Several viruses, including influenza, induce an imbalance of intracellular redox state toward pro-oxidant conditions. Through different mechanisms these alterations contribute both to influenza virus replication and to the pathogenesis of virus-induced disease. At the same time, influenza virus activates several intracellular signaling pathways involved in important physiological functions of the cell. Interestingly, many of these pathways are finely regulated by small changes in intracellular redox state, and the virus-induced redox imbalance might also control viral replication through this mechanism. Here we review the main intracellular redox-sensitive pathways activated upon influenza infection and involved in regulating viral replication.
authors: G. Sanarelli Department of Public Health Sciences, La Sapienza University of Rome, Italy.
authors: Lucia
authors: L
authors: Nencioni
authors: Rossella
authors: R
authors: Sgarbanti
authors: Giovanna
authors: G
authors: De Chiara
authors: Enrico
authors: E
authors: Garaci
authors: Anna Teresa
authors: AT
authors: Palamara
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D015195:Drug Design; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000378:metabolism* / Q000821:virology*; D010084:Oxidation-Reduction; D015398:Signal Transduction; D014779:Virus Replication
chemical_list: D000890:Anti-Infective Agents; D020928:Mitogen-Activated Protein Kinases