In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
Nersesian
Diana L
DL
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. diana.nersesian@abbott.com
Black
Lawrence A
LA
Miller
Thomas R
TR
Vortherms
Timothy A
TA
Esbenshade
Timothy A
TA
Hancock
Arthur A
AA
Cowart
Marlon D
MD
D000818:Animals; D054828:Histamine H3 Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
C520125:2-methylpyrrolidine; D054828:Histamine H3 Antagonists; D011759:Pyrrolidines