title: [Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis].
abstract: OBJECTIVE
  To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).
  
  
  METHODS
  226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.
  
  
  RESULTS
  The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.
  
  
  CONCLUSIONS
  The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.
authors: Spine Surgery, Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China.
authors: Xu-sheng
authors: XS
authors: Qiu
authors: Leung-sang
authors: LS
authors: Tang
authors: Hiu-yan
authors: HY
authors: Yeung
authors: Hoi-kei
authors: HK
authors: Kwok
authors: Kwong-man
authors: KM
authors: Lee
authors: Ling
authors: L
authors: Qin
authors: Yong
authors: Y
authors: Qiu
authors: Chun-yiu
authors: CY
authors: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044122:Receptor, Melatonin, MT1 / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics*
chemical_list: D044122:Receptor, Melatonin, MT1