Systems biological and mechanistic modelling of radiation-induced cancer.
This paper summarises the five presentations at the First International Workshop on Systems Radiation Biology that were concerned with mechanistic models for carcinogenesis. The mathematical description of various hypotheses about the carcinogenic process, and its comparison with available data is an example of systems biology. It promises better understanding of effects at the whole body level based on properties of cells and signalling mechanisms between them. Of these five presentations, three dealt with multistage carcinogenesis within the framework of stochastic multistage clonal expansion models, another presented a deterministic multistage model incorporating chromosomal aberrations and neoplastic transformation, and the last presented a model of DNA double-strand break repair pathways for second breast cancers following radiation therapy.
Little
M P
MP
Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London W2 1PG, UK. mark.little@imperial.ac.uk
Heidenreich
W F
WF
Moolgavkar
S H
SH
Schöllnberger
H
H
Thomas
D C
DC
D000818:Animals; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D011839:Radiation, Ionizing; D015398:Signal Transduction; D013269:Stochastic Processes; D049490:Systems Biology / Q000379:methods*