"JIP"ing along the axon: the complex roles of JIPs in axonal transport.
JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to Kinesin-I, a major molecular motor for axonal transport. Recent research sheds further light on JIPs' complex roles in axonal transport, namely in activation of Kinesin-I and in cargo release. In Drosophila, APLIP1/JIP1 allows the Kinesin-I complex to enable cargo release through activation of JNK signaling.1 In mammalian cell culture, JIP1 is necessary and, together with UNC-76/FEZ1, sufficient for activating Kinesin-I.2 I discuss and compare the many roles played by JIP1 and JIP3 through interactions with several distinct players, in retrograde as well as anterograde transport.
Koushika
Sandhya P
SP
NCBS-TIFR, Bellary Road, Bangalore-560065, India. koushika@ncbs.res.in
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D008954:Models, Biological; D005810:Multigene Family / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology
C524132:APP-like protein interacting protein 1, Drosophila; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; C490666:MAPK8IP1 protein, human; C485750:MAPK8IP3 protein, human; D009419:Nerve Tissue Proteins; C515209:Khc protein, Drosophila; D016547:Kinesins