Renal cell carcinoma in a child presented as bilateral femur neck fractures caused by severe vitamin D deficiency.
An Ethiopian girl 14 years and 11 months of age presented with bilateral transcervical hip fractures. Workup revealed severe vitamins D and C deficiencies with secondary hyperparathyroidism. Imaging studies showed bilateral radiolucent metaphyseal bands with multiple lytic lesions in long bones. A mass in the right flank was found to be renal cell carcinoma (RCC). Currently, 9 months postsurgery and supplemental therapy, the patient is fully ambulatory and free of pain. This first report of asymptomatic RCC in severely vitamin D deficient child highlights the relation of RCC to vitamin D deficiency and emphasizes the importance of careful evaluation of these children.
Aviner
Shraga
S
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Isreal. aviners@barzi.health.gov.il
Dabby
Dan
D
London
Daniel
D
Feinmesser
Meora
M
Ash
Shifra
S
Steinberg
Ran
R
Jakim
Itzhak
I
D000293:Adolescent; D001205:Ascorbic Acid / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005265:Femoral Neck Fractures / Q000000981:diagnostic imaging*; D007839:Functional Laterality; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications*
D014807:Vitamin D; D001205:Ascorbic Acid