title: Structure elucidation and NMR spectral assignments of three new lignan glycosides from Akebia trifoliata.
abstract: Three new lignan glycosides (1-3) were isolated from the stems of Akebia trifoliata. Their structures were elucidated as (7R,8R,7'R,8'R)3,3',5,5'tetramethoxy-4,4'dihydroxy-7,9':7',9-diepoxylignan-4-O-beta-D-glucopyranoside (1), (7S,8S,8'R)-4,4',9-trihydroxy-3,3',5,5'-tetramethoxy-7,9'-epoxylignan-7'-one 9-O-beta-D-glucopyranoside (2), (7R,8R,8'S)-4,4',9-trihydroxy3,3',5,5'-tetramethoxy-7,9'-epoxylignan-7'-one 9-O-beta-D-glucopyranoside (3) by spectral analyses, primarily NMR, MS and CD. The NMR assignments for the compounds were carried out using 1H, 13C, DEPT, COSY, HSQC, HMBC and ROESY NMR experiments.
authors: Shanghai Research Center for TCM Modernization, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Zhangjiang Hitech Park, Guoshoujing Road #199, Shanghai 201203, P.R. China.
authors: Shu-Hong
authors: SH
authors: Guan
authors: Jia-Meng
authors: JM
authors: Xia
authors: Zhi-Qiang
authors: ZQ
authors: Lu
authors: Guang-Tong
authors: GT
authors: Chen
authors: Bao-Hong
authors: BH
authors: Jiang
authors: Xuan
authors: X
authors: Liu
authors: De-An
authors: DA
authors: Guo
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D029626:Ranunculaceae / Q000737:chemistry*
chemical_list: C527898:3,3',5,5'-tetramethoxy-4,4'-dihydroxy-7,9'-7',9-diepoxylignan-4-O-glucopyranoside; C527899:4,4',9-trihydroxy-3,3',5,5'-tetramethoxy-4,4'-dihydroxy-7,9'-epoxylignan-7'-one 9-O-glucopyranoside; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D017705:Lignans