title: Severe airflow limitation in two patients with systemic lupus erythematosus: effect of inhalation of anticholinergics.
abstract: Airway involvement clinically presenting as dyspnea and an obstructive ventilatory defect is a rare but clinically important complication in systemic lupus erythematosus (SLE), since the airway manifestation is often progressive and resistant to systemic immunosuppressive therapy. Here we report two SLE patients with slowly progressive airflow limitation, which was clinically thought to be bronchiolitis obliterans. Both patients showed obvious improvement after inhalation of anticholinergics was started. Because anticholinergics are highly safe and never immunosuppressive, inhalation of these drugs might be useful in the therapeutic strategies for airflow limitation accompanying SLE or other collagen diseases.
authors: Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. kawabata-phy@h.u-tokyo.ac.jp
authors: Kimito
authors: K
authors: Kawahata
authors: Masao
authors: M
authors: Yamaguchi
authors: Hiroko
authors: H
authors: Kanda
authors: Akiko
authors: A
authors: Komiya
authors: Ryoichi
authors: R
authors: Tanaka
authors: Makoto
authors: M
authors: Dohi
authors: Yoshikata
authors: Y
authors: Misaki
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001989:Bronchiolitis Obliterans / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018680:Cholinergic Antagonists / Q000008:administration & dosage*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D011859:Radiography
chemical_list: D018680:Cholinergic Antagonists