Adult height of three renal transplant patients after growth hormone therapy.
Three girls with normal growth hormone secretion had received renal transplantation when aged 2 to 6 years. They had had severely retarded growth (SD for height score was -7.4 to -3.7) at the time of transplantation. After renal transplantation, steroid was withdrawn and they were treated with recombinant human growth hormone; they subsequently reached adult heights of 145 to 156 cm. The SD for adult height score was -2.6 to -0.3. The adult height in two patients was over their target height, calculated using the mean of the parents' height. This report shows the efficacy of steroid withdrawal and recombinant human growth hormone therapy in achieving adult height in these three girls after renal transplantation.
Motoyama
Osamu
O
Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura-shi, Chiba, 285-8741, Japan. motoyan@basil.ocn.ne.jp.
Hasegawa
Akira
A
Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Kawamura
Takeshi
T
Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Aikawa
Atushi
A
Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Iitaka
Kikuo
K
Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Shizuoka, Japan.
D000328:Adult; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D011994:Recombinant Proteins / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000150:complications* / Q000601:surgery
D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D019382:Human Growth Hormone