How microorganisms tip the balance between interleukin-12 family members.
Interleukin-12p70 (IL-12p70) induces T-helper-1-cell responses and IL-23, a related cytokine, is the master switch in several T-cell-mediated inflammatory disorders. IL-27, another member of the IL-12 family, regulates innate and adaptive immune responses. Recently, distinct combinations of transcription factors have been shown to regulate the expression of the genes that encode these three cytokines. Toll-like receptor ligands, in association with other microbial products and endogenous mediators, tip the balance between the expression of IL-12 family members and thereby may control the outcome of T-cell-mediated inflammation. On this basis, we present a novel perspective on the pathogenesis and regulation of inflammatory disorders.
Goriely
Stanislas
S
Stanislas Goriely and Michel Goldman are at the Institute for Medical Immunology, Université Libre de Bruxelles, 8 rue Adrienne Bolland, B-6041 Charleroi, Belgium.
Neurath
Markus F
MF
Goldman
Michel
M
D000818:Animals; D015870:Gene Expression / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D018664:Interleukin-12