Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?
Choi
Se Hoon
SH
Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.
Norstrom
Eric
E
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000517:prevention & control; D002478:Cells, Cultured; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D018450:Disease Progression; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D012878:Skin Neoplasms / Q000235:genetics* / Q000517:prevention & control; D013163:Splenomegaly / Q000235:genetics / Q000517:prevention & control; D015996:Survival Rate
D016229:Amyloid beta-Peptides; D053829:Amyloid Precursor Protein Secretases