Enhanced detectability of recurrent brain tumor using glucose-loading F-18 FDG PET.
A 43-year-old man with a history of lung cancer, brain metastasis, and gamma knife radiosurgery underwent FDG PET/CT to differentiate recurrence from radiation necrosis. Basal PET/CT scan showed equivocal uptake in the margin of necrotic tumor. After glucose loading (10% glucose 50 mL for 5 minutes), marginal FDG uptake was more easily depicted. Proton magnetic resonance spectroscopy (1H-MRS) showed increased Cho/Cr ratio (1.7), which was consistent with tumor recurrence. The patient underwent whole brain radiotherapy thereafter. It is implicated that hyperglycemia-induced reduction of glucose uptake in recurrent brain tumors was less than in a normal brain, resulting in higher tumor-to-gray matter ratio.
Seo
Young-Soon
YS
Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea.
Chung
Tae-Woong
TW
Kim
In-Young
IY
Bom
Hee-Seung
HS
Min
Jung-Joon
JJ
D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D003287:Contrast Media; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D019786:Gadolinium DTPA; D005947:Glucose; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D019786:Gadolinium DTPA