Skeletal ("mesenchymal") stem cells for tissue engineering.
Skeletal stem cells (SSCs, commonly referred to as "mesenchymal" stem cells) are found in the bone marrow stromal cell (BMSC) fraction of post-natal bone marrow. They can be isolated in culture as adherent, clonogenic cells endowed with the ability to grow and differentiate into multiple lineages, all of which correspond to tissues that are integral parts of the skeleton. The multipotency of SSCs is probed by in vivo transplantation assays. The ability of SSCs to generate a cell strain competent to form significant amounts of bone in vivo has led to the formulation of preclinical models of bone repair.
Robey
Pamela Gehron
PG
Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Kuznetsov
Sergei A
SA
Riminucci
Mara
M
Bianco
Paolo
P
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D002130:Calcium Phosphates / Q000378:metabolism; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D006801:Humans; D006882:Hydroxyapatites / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D003094:Collagen; C018392:tricalcium phosphate