Electric field-induced translocation of single-stranded DNA through a polarized carbon nanotube membrane.
Molecular dynamics simulations based on a novel polarizable nanotube model were performed to study the dynamics in translocation of a single-stranded deoxyribonucleic acid oligonucleotide through a polarized carbon nanotube membrane by an applied electric field. The study revealed a nonlinear dependence of translocation velocity and an inverse quadratic dependence of translocation time on the electric field strength, as well as a threshold electric field below which the translocation process becomes impossible. The translocation rate was found to be pore-size dependent. The polarizable nanotube model developed for this study provides a useful platform for investigating the dynamics of a range of bionanosystems.
Xie
Yinghong
Y
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong. xieh@hkusua.hku.hk
Kong
Yong
Y
Soh
A K
AK
Gao
Huajian
H
D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects* / Q000648:ultrastructure; D004574:Electromagnetic Fields; D018274:Electroporation / Q000379:methods*; D008567:Membranes, Artificial; D008956:Models, Chemical; D008958:Models, Molecular; D009038:Motion; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure*; D055672:Static Electricity
D008567:Membranes, Artificial; D037742:Nanotubes, Carbon; D004247:DNA