title: Anatomically based lower limb nerve model for electrical stimulation.
abstract: BACKGROUND
  Functional Electrical Stimulation (FES) is a technique that aims to rehabilitate or restore functionality of skeletal muscles using external electrical stimulation. Despite the success achieved within the field of FES, there are still a number of questions that remain unanswered. One way of providing input to the answers is through the use of computational models.
  
  
  METHODS
  This paper describes the development of an anatomically based computer model of the motor neurons in the lower limb of the human leg and shows how it can be used to simulate electrical signal propagation from the beginning of the sciatic nerve to a skeletal muscle. One-dimensional cubic Hermite finite elements were used to represent the major portions of the lower limb nerves. These elements were fit to data that had been digitised using images from the Visible Man project. Nerves smaller than approximately 1 mm could not be seen in the images, and thus a tree-branching algorithm was used to connect the ends of the fitted nerve model to the respective skeletal muscle. To simulate electrical propagation, a previously published mammalian nerve model was implemented and solved on the anatomically based nerve mesh using a finite difference method. The grid points for the finite difference method were derived from the fitted finite element mesh. By adjusting the tree-branching algorithm, it is possible to represent different levels of motor-unit recruitment.
  
  
  RESULTS
  To illustrate the process of a propagating nerve stimulus to a muscle in detail, the above method was applied to the nerve tree that connects to the human semitendinosus muscle. A conduction velocity of 89.8 m/s was obtained for a 15 mum diameter nerve fibre. This signal was successfully propagated down the motor neurons to a selected group of motor units in the muscle.
  
  
  CONCLUSIONS
  An anatomically and physiologically based model of the posterior motor neurons in the human lower limb was developed. This model can be used to examine the effect of external stimulation on nerve and muscle activity, as may occur, for example, in the field of FES.
authors: Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand. juliana.kim@auckland.ac.nz
authors: Juliana H K
authors: JH
authors: Kim
authors: John B
authors: JB
authors: Davidson
authors: Oliver
authors: O
authors: Röhrle
authors: Tanya K
authors: TK
authors: Soboleva
authors: Andrew J
authors: AJ
authors: Pullan
mesh_terms: D003198:Computer Simulation; D004558:Electric Stimulation / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D035002:Lower Extremity / Q000294:innervation* / Q000502:physiology; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D012584:Sciatic Nerve / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology