[Antihypoxant effect of zinc(II) bis(N-acetyl-L-cysteinato)sulfate octahydrate in acute normobaric hypoxia].
Using two models of the acute normobaric hypercapnic hypoxia (ANHH) and acute normobaric hypoxia without hypercapnia (ANWH), some parameters of the impulse activity of somatosensory cortex neurons were studied in experiments on cats. A new antihypoxant drug--aminothiol complex substance composed of zinc(II) and N-acetyl-L-cysteine (piQ-1104, 50 mg/kg)--was used for the brain protection. The substance studied showed a high antihypoxant activity in the brain neurons during all stages of both ANHH and AHWH. The average active survival time during hypoxic state was increased 2-2.5 times in comparison to the control group. The neuron activity dynamics under ANHH and AHWH conditions and after piQ-1104 injection was observed.
Evseev
A V
AV
Evseeva
M A
MA
Parfenov
E A
EA
Pravdivtsev
V A
VA
Shabanov
P D
PD
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002415:Cats; D004558:Electric Stimulation; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D006935:Hypercapnia / Q000150:complications / Q000517:prevention & control; D000860:Hypoxia / Q000150:complications / Q000517:prevention & control*; D009474:Neurons / Q000502:physiology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000503:physiopathology
D000975:Antioxidants; D018696:Neuroprotective Agents; C526939:zinc(II) bis(N-acetyl-L-cysteinato)sulfate; D000111:Acetylcysteine