title: Intensive care unit exposures for long-term outcomes research: development and description of exposures for 150 patients with acute lung injury.
abstract: OBJECTIVE
  Long-term follow-up studies in critical care have described survivors' outcomes, but provided less insight into the patient/disease characteristics and intensive care therapies ("exposures") associated with these outcomes. Such insights are essential for improving patients' long-term outcomes. This report describes the development of a strategy for comprehensively measuring relevant exposures for long-term outcomes research, and presents empiric results from its implementation.
  
  
  METHODS
  A multistep, iterative process was used to develop the exposures strategy. First, a comprehensive list of potential exposures was generated and subsequently reduced based on feasibility, redundancy, and relevance criteria. Next, data abstraction methods were designed and tested. Finally, the strategy was implemented in 150 patients with acute lung injury with iterative refinement.
  
  
  RESULTS
  The strategy resulted in the development of more than 60 unique exposures requiring less than 45 minutes per patient-day for data collection. Most exposures had minimal missing data and adequate reliability. These data revealed that evidence-based practices including lower tidal volume ventilation, spontaneous breathing trials, sedation interruption, adequate nutrition, and blood glucose of less than 6.1 mmol/L (110 mg/dL) occurred in only 23% to 50% of assessments.
  
  
  CONCLUSIONS
  Using a multistep, iterative process, a comprehensive and feasible exposure measurement strategy for long-term outcomes research was successfully developed and implemented.
authors: Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. dale.needham@jhmi.edu
authors: Dale M
authors: DM
authors: Needham
authors: Weiwei
authors: W
authors: Wang
authors: Sanjay V
authors: SV
authors: Desai
authors: Pedro A
authors: PA
authors: Mendez-Tellez
authors: Cheryl R
authors: CR
authors: Dennison
authors: Jonathan
authors: J
authors: Sevransky
authors: Carl
authors: C
authors: Shanholtz
authors: Nancy
authors: N
authors: Ciesla
authors: Kim
authors: K
authors: Spillman
authors: Peter J
authors: PJ
authors: Pronovost
mesh_terms: D000328:Adult; D000368:Aged; D015142:Baltimore; D015331:Cohort Studies; D003625:Data Collection / Q000379:methods; D004812:Epidemiologic Methods; D005260:Female; D006304:Health Status; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011446:Prospective Studies; D011788:Quality of Life; D012107:Research Design; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000628:therapy*; D012307:Risk Factors