title: Synthesis and cytotoxicity of a cobaltcarbonyl-alkyne enkephalin bioconjugate.
abstract: A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co(2)(CO)(8) to give the Co(2)(CO)(6)-alkyne labeled peptide , which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.
authors: Lehrstuhl für Anorganische Chemie I - Bioanorganische Chemie, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätstr. 150, D - 44801 Bochum, Germany.
authors: Merja A
authors: MA
authors: Neukamm
authors: Antonio
authors: A
authors: Pinto
authors: Nils
authors: N
authors: Metzler-Nolte
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002255:Carbonic Acid / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D004745:Enkephalins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
chemical_list: D000480:Alkynes; D004745:Enkephalins; D003035:Cobalt; D002255:Carbonic Acid