title: Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques.
abstract: Tissue characterization of plaques of coronary arteries is important to clarify the process of acute coronary syndrome and prevent it. The purpose of this study is to develop an online integrated backscatter intravascular ultrasound (IB-IVUS) system and validate the diagnostic accuracy for the characterization of coronary plaques. A personal computer equipped with custom software was connected to an IVUS imaging system. Images were acquired from 242 segments of 46 coronary arteries from 25 cadavers obtained at autopsy. In the training study, a total of 724 regions-of-interests on color-coded maps were compared with histologic images. In the validation study, a total of 192 cross-sections of coronary arteries were evaluated. Receiver operating characteristic curve analysis showed that the cut-off points of -49 dB (area under curve = 0.98) and -29 dB (area under curve = 0.99) were the most reliable predictors of lipid pools, fibrosis and calcification. In the validation study, the analysis using IB values classified fibrous, lipid-rich and fibrocalcific plaque components with a high accuracy of 93%, 90% and 96%, respectively. The overall agreement between histologic and IB-IVUS diagnoses (n = 175) was high (Cohen's kappa = 0.81). The IB-IVUS system provides high diagnostic accuracy for analysis of tissue characteristics of coronary plaques.
authors: Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan.
authors: Munenori
authors: M
authors: Okubo
authors: Masanori
authors: M
authors: Kawasaki
authors: Yoshiyuki
authors: Y
authors: Ishihara
authors: Urara
authors: U
authors: Takeyama
authors: Tomoki
authors: T
authors: Kubota
authors: Takahiko
authors: T
authors: Yamaki
authors: Shinsuke
authors: S
authors: Ojio
authors: Kazuhiko
authors: K
authors: Nishigaki
authors: Genzou
authors: G
authors: Takemura
authors: Masanao
authors: M
authors: Saio
authors: Tsuyoshi
authors: T
authors: Takami
authors: Shinya
authors: S
authors: Minatoguchi
authors: Hisayoshi
authors: H
authors: Fujiwara
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008055:Lipids / Q000032:analysis; D015203:Reproducibility of Results; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D008055:Lipids