Off-line fractional exhaled nitric oxide measurement is useful to screen allergic airway inflammation in an adult population.
To determine whether off-line fractional exhaled nitric oxide (FeNO) measurement is applicable to screen allergic airway inflammation for epidemiologic studies, we examined 280 adults, measuring off-line FeNO samplings, pulmonary function, and serum immunoglobulin E (IgE). Subjects with recurrent wheeze (recurrent wheezers) had significantly higher FeNO and IgE levels and significantly lower forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) than non-wheezers. Statistical analysis showed that FeNO and FEV1/FVC were significant predictors for recurrent wheezers, independent of smoking. The cut-off FeNO level for screening allergic airway inflammation was 38 ppb in non-smokers and 32.9 ppb in smokers. Thus, off-line FeNO can be used as a good marker to screen allergic airway inflammation, regardless of smoking.
Saito
Junpei
J
Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan. junpei@fmu.ac.jp
Sato
Suguru
S
Hasunuma
Hideki
H
Ishimaru
Yasushi
Y
Kanegae
Hiroshi
H
Kudo
Shoji
S
Munakata
Mitsuru
M
D000328:Adult; D000368:Aged; D045853:Exhalation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D012130:Respiratory Hypersensitivity / Q000378:metabolism*; D012135:Respiratory Sounds
D009569:Nitric Oxide