Seizures in a pediatric patient with a tiagabine overdose.
BACKGROUND
Tiagabine (TGB) is a novel antiepileptic that decreases GABA uptake. The literature contains one report of an adult with epilepsy who ingested up to 1 gram of TGB and developed status epilepticus. We reported on a pediatric patient who ingested significantly less TGB but still developed tonic-clonic seizures.


METHODS
A previously healthy, 13 kg, two-year-old girl developed generalized tonic-clonic seizure activity at home approximately 1 hour after ingesting 90 mg of her grandmother's TGB (forty five 2 mg tablets). At the hospital she had two 5 minute seizures at 1.5 and 3.5 hours post ingestion. Her serum TGB levels were 530 and 130 ng/ml approximately 5 and 11 hours post-ingestion (5-70 ng/ml trough levels with most probable range for seizure control). She was discharged 27 hours post ingestion, and she was in good condition.


CONCLUSIONS
An overdose of TGB, a novel anti-epileptic, can cause convulsive seizures.
Kazzi
Ziad N
ZN
Department of Emergency Medicine, University of Alabama at Birmingham, USA. zkazzi@uabmc.edu
Jones
Chris C
CC
Morgan
Brent W
BW
D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D002675:Child, Preschool; D062787:Drug Overdose; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009557:Nipecotic Acids / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine