title: Loading and in vitro controlled release of indomethacin using amphiphilic cholesteryl-bearing carboxymethylcellulose derivatives.
abstract: Amphiphilic CCMCs were synthesized under mild conditions and their chemical structures were characterized by FT-IR and 1H NMR spectroscopy. Fluorescence analysis showed that CCMCs could self-associate to form polymeric micelles in aqueous solution. IND was encapsulated during the formation of CCMC micelles and its in vitro release properties were investigated. The loading capacity was more than 50% and the loaded IND was slowly and steadily released into the medium over a period of 8 h. The CCMC micelles showed pH-responsive behavior during the drug-loading and release processes. CCMC is promising as a potential delivery system for the controlled release of IND with a pH-responsive property.
authors: Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. yanglq@mail.sysu.edu.cn
authors: Liqun
authors: L
authors: Yang
authors: Jianliang
authors: J
authors: Kuang
authors: Jun
authors: J
authors: Wang
authors: Zhiquan
authors: Z
authors: Li
authors: Li-Ming
authors: LM
authors: Zhang
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D013501:Surface-Active Agents; D002266:Carboxymethylcellulose Sodium; D007213:Indomethacin