Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure.
We studied the IZUMO gene 9 coding exons sequence in four groups of patients including those with fertilization failure by conventional IVF. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.
Granados-Gonzalez
Viviana
V
Laboratoire de Biologie de la Reproduction, Hôpital Nord, CHU de Saint-Etienne, Saint Etienne, France.
Aknin-Seifer
Isabelle
I
Touraine
Renaud-Lauriam
RL
Chouteau
Jacques
J
Wolf
Jean-Philippe
JP
Levy
Rachel
R
D002478:Cells, Cultured; D005091:Exons / Q000235:genetics; D005260:Female; D005306:Fertilization / Q000235:genetics*; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009865:Oocytes; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D013094:Spermatozoa
C498176:IZUMO1 protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins