Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population.
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America. Our aim was to determine whether these SNPs were associated with MI in a southern Europe/Mediterranean population. We employed a case-control association design involving 416 MI patients and 308 non-MI controls from Italy. Significant allelic association was identified between all four SNPs and MI. The association remained significant after adjusting for covariates for MI (P=0.007-0.029). One risk haplotype (GGGG; P=0.028) and one protective haplotype (AAAA; P=0.047) were identified. Genotypic association analysis demonstrated that the SNPs conferred susceptibility to MI most likely in a dominant model (P=0.0007-0.013). When the case cohort was divided into a group of MI patients with a family history (n=248) and one group without it (n=168), the positive, significant association was identified only in the group with the family history. These results indicate that chromosome 9p21 confers risk for development of MI in an Italian population.
Shen
Gong-Qing
GQ
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Rao
Shaoqi
S
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Martinelli
Nicola
N
Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
Li
Lin
L
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Olivieri
Oliviero
O
Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
Corrocher
Roberto
R
Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy.
Abdullah
Kalil G
KG
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.
Hazen
Stanley L
SL
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Smith
Jonathan
J
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Barnard
John
J
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.|Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Plow
Edward F
EF
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.|Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.
Girelli
Domenico
D
Department of Clinical and Experimental Medicine, University of Verona, 37134, Verona, Italy. domenico.girelli@univr.it.
Wang
Qing K
QK
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. wangq2@ccf.org.|Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA. wangq2@ccf.org.
D000483:Alleles; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*