title: Highly chemoselective metal-free reduction of tertiary amides.
abstract: This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.
authors: Département de chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Quebec, Canada H3C 3J7.
authors: Guillaume
authors: G
authors: Barbe
authors: André B
authors: AB
authors: Charette
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis*; D000812:Anhydrides; D006865:Hydrogenation; D019163:Reducing Agents
chemical_list: D000577:Amides; D000588:Amines; D000812:Anhydrides; D019163:Reducing Agents