title: [Pathogen spectrum and drug resistance of spit samples from cancer patients].
abstract: OBJECTIVE
  Some cancer patients were not died of cancer, but died of infection after operation, chemotherapy, radiotherapy, or interventional treatment. This study was to investigate the pathogen spectrum and drug resistance of spit samples from cancer patients.
  
  
  METHODS
  The pathogen spectrum and drug resistance of 955 positive spit samples from cancer patients were analyzed with WHONET-5 statistical software.
  
  
  RESULTS
  The detection rates were 43.3% for fungus (mainly included C.albicans), 31.2% for Gram-positive coccus (mainly included coagulase-negative Staphylococcus), and 25.5% for Gram-negative bacillus (mainly included P.aeruginosa and K.pneumonia). Drug sensitivity test showed that fungus was sensitive to amphotericin B, but resistant against categorical azoles; Gram-positive coccus was highly sensitive to vancomycin, but highly resistant against oxacillin, penicillin and erythromycin; Gram-negative bacillus was highly sensitive to impanel, but highly resistant against the first and second generations of cephalosporin such as ampicillin and piperacillin.
  
  
  CONCLUSIONS
  The pathogen spectrum of cancer patients with nosocomial infection mainly includes fungus, Gram-positive coccus, and Gram-negative coccus. Treating cancer patients with antibiotics should be based on drug sensitivity test.
authors: State Key Laboratory of Oncology in South China, Guangzhou, Gangdong, 510060, PR China. wuxingp@mail.sysu.edu.cn
authors: Xing-Ping
authors: XP
authors: Wu
authors: Lin
authors: L
authors: Zhang
authors: Xiao-Li
authors: XL
authors: Tan
authors: Xiao-Min
authors: XM
authors: Liu
authors: Li-Rong
authors: LR
authors: He
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009369:Neoplasms / Q000382:microbiology*; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents