[Effect of tamoxifen on anxiety in ovariectomized and intact female rats].
The effect of tamoxifen (estrogen receptor modulator) administered in a daily dose of 10 mg/kg (i.p.) over 14 days on the behavioral state of female rats has been studied in various phase of the sexual cycle and in the state of estrogen deficiency. In the elevated-plus-maze and open-field tests, the administration of tamoxifen to intact rats was accompanied by anxiolytic and/or anxiogenic effects, depending on the phase of the sexual cycle. The ovaryectomy led to a sharp increase in the anxiety. The chronic administration of tamoxifen in ovaryectomized female rats produced a stronger anxiolytic effect in comparison to 17beta3-estradiol. The results show that tamoxifen produces a modulating action on the state of anxiety, which depends on the estrogen level in the blood.
Kazakova
S B
SB
Fedotova
Iu O
IuO
Sapronov
N S
NS
D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D030762:Estrous Cycle; D005260:Female; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000494:pharmacology*
D020847:Estrogen Receptor Modulators; D004967:Estrogens; D013629:Tamoxifen; D004958:Estradiol