Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes.
BACKGROUND
Oxidative stress (OxS) has recently been linked with osteoporosis; however, we do not know the influence of OxS as an independent risk factor for this disease.


METHODS
We conducted a case-control study in 94 subjects > or =60 years of age, 50 healthy and 44 with osteoporosis. We measured total antioxidant status, plasma lipid peroxides, antioxidant activity of superoxide dismutase and glutathione peroxidase (GPx), and calculated the SOD/GPx ratio. Bone mineral density was obtained at the peripheral DXA in calcaneus using a portable Norland Apollo Densitometer. Osteoporosis was considered when subjects had a BMD of 2.5 standard deviations or more below the mean value for young adults.


RESULTS
GPx antioxidant activity was significantly lower in the group of subjects with osteoporosis in comparison with the group of healthy subjects (p < 0.01); in addition, the SOD/GPx ratio was significantly higher in the group of individuals with osteoporosis (p < 0.05). In logistic regression analysis, we found OxS to be an independent risk factor for osteoporosis (odds ratio [OR] = 2.79; 95% confidence interval [95% CI] = 1.08-7.23; p = 0.034).


CONCLUSIONS
Our findings suggest that OxS is an independent risk factor for osteoporosis linked to increase of SOD/GPx ratio.
Sánchez-Rodríguez
Martha A
MA
Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), México DF, México. masanrod@yahoo.com.mx
Ruiz-Ramos
Mirna
M
Correa-Muñoz
Elsa
E
Mendoza-Núñez
Víctor Manuel
VM
D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015992:Body Mass Index; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010024:Osteoporosis / Q000201:enzymology*; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase