title: Prevalence of the Child Behavior Checklist-pediatric bipolar disorder phenotype in a German general population sample.
abstract: BACKGROUND
  In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date.
  
  
  OBJECTIVE
  To estimate the six-month prevalence of the CBCL-PBD profile in Germany in a large normative general population sample, and to examine subjects with CBCL-PBD profile with regard to symptoms assumed to coexist with PBD (e.g., suicidality, decreased need for sleep, and hypersexuality).
  
  
  METHODS
  We studied a nationwide representative general population sample of 2,856 children and adolescents aged 4-18 years.
  
  
  RESULTS
  A total of 21 subjects [0.7% of the sample; 95% confidence interval (CI) = 0.5-1.1] met the criteria for the CBCL-PBD phenotype. CBCL-PBD subjects were more pervasively disturbed than clinical controls (n = 118; 4.1% of total sample; 95% CI = 3.4-4.9), demonstrated in significantly more social problems and delinquent behavior, and showed significantly higher rates of suicidality, decreased need for sleep and hypersexual behavior.
  
  
  CONCLUSIONS
  The prevalence of CBCL-PBD subjects in the general German population compares to rates of PBD in US and Dutch epidemiological samples. Regardless of whether these subjects are affected by 'real' PBD or 'severe, pervasive ADHD' with pronounced emotional dysregulation, they constitute a group of seriously disturbed children and adolescents. The high rate of suicidality among CBCL-PBD subjects emphasizes the need for the identification and adequate treatment of children meeting this profile.
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, JW Goethe-University, Frankfurt/Main, Germany. holtmann@em.uni-frankfurt.de
authors: Martin
authors: M
authors: Holtmann
authors: Sven
authors: S
authors: Bölte
authors: Kirstin
authors: K
authors: Goth
authors: Manfred
authors: M
authors: Döpfner
authors: Julia
authors: J
authors: Plück
authors: Michael
authors: M
authors: Huss
authors: Jörg M
authors: JM
authors: Fegert
authors: Gerd
authors: G
authors: Lehmkuhl
authors: Klaus
authors: K
authors: Schmeck
authors: Fritz
authors: F
authors: Poustka
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000523:psychology*; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D010372:Pediatrics; D010556:Personality Tests; D010641:Phenotype; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012680:Sensitivity and Specificity