title: Alkyne-azide click chemistry mediated carbanucleosides synthesis.
abstract: Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.
authors: Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, Orléans, France.
authors: Julie
authors: J
authors: Broggi
authors: Nicolas
authors: N
authors: Joubert
authors: Vincent
authors: V
authors: Aucagne
authors: Sabine
authors: S
authors: Berteina-Raboin
authors: S
authors: S
authors: Diez-Gonzalez
authors: Steve
authors: S
authors: Nolan
authors: Dimitri
authors: D
authors: Topalis
authors: Dominique
authors: D
authors: Deville-Bonne
authors: Jan
authors: J
authors: Balzarini
authors: Johan
authors: J
authors: Neyts
authors: Graciela
authors: G
authors: Andrei
authors: Robert
authors: R
authors: Snoeck
authors: Luigi A
authors: LA
authors: Agrofoglio
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D008872:Microwaves; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D000998:Antiviral Agents; D001386:Azides; D009705:Nucleosides; D014230:Triazoles