Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.
Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3), and D(4)) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.
Zeng
Chunyu
C
Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City 400042, People's Republic of China. cyzeng1@hotmail.com
Armando
Ines
I
Luo
Yingjin
Y
Eisner
Gilbert M
GM
Felder
Robin A
RA
Jose
Pedro A
PA
D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D011954:Receptors, Dopamine / Q000235:genetics* / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000235:genetics / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000502:physiology; D050637:Receptors, Dopamine D3 / Q000235:genetics / Q000502:physiology; D050638:Receptors, Dopamine D4 / Q000235:genetics / Q000502:physiology; D050641:Receptors, Dopamine D5 / Q000235:genetics / Q000502:physiology
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4; D050641:Receptors, Dopamine D5; D004298:Dopamine