Damage-induced reactivation of cohesin in postreplicative DNA repair.
Cohesin establishes sister-chromatid cohesion during S phase to ensure proper chromosome segregation in mitosis. It also facilitates postreplicative homologous recombination repair of DNA double-strand breaks by promoting local pairing of damaged and intact sister chromatids. In G2 phase, cohesin that is not bound to chromatin is inactivated, but its reactivation can occur in response to DNA damage. Recent papers by Koshland's and Sjögren's groups describe the critical role of the known cohesin cofactor Eco1 (Ctf7) and ATR checkpoint kinase in damage-induced reactivation of cohesin, revealing an intricate mechanism that regulates sister-chromatid pairing to maintain genome integrity.
Ball
Alexander R
AR
Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA.
Yokomori
Kyoko
K
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism* / Q000502:physiology; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000378:metabolism* / Q000502:physiology; D016681:Genome, Fungal; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology; D012854:Sister Chromatid Exchange / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004271:DNA, Fungal; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D000097722:Cohesins