title: Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up.
abstract: BACKGROUND
  Metabolic syndrome is a group of pathological processes which involve insulin resistance, a biochemical and molecular disorder. Obesity appears to be the most frequent clinical component in metabolic syndrome. Subcutaneous fat, independent from visceral fat, is still controversial as a marker of the pathophysiology of insulin resistance.
  
  
  METHODS
  An open parallel-group clinical trial was performed of 12 women (age 30-40 years), with BMI from 30-33 kg/m2 and fasting glucose < or =110 mg/dl. 6 women were included in the "liposuction plus diet" group, and 6 were included in the "diet-only" group. Metabolic profile, including insulin tolerance test (ITT), leptin and tumor necrosis factor alpha (TNFalpha), was performed at baseline, 1 and 6 months in both groups. Subcutaneous and visceral fat was quantified with spiral tomography at baseline and after 6 months. Friedman and Wilcoxon test were used for intra-group differences, Mann-Whitney U for differences between groups, and Spearman test for correlation, with significance set at P<0.05.
  
  
  RESULTS
  No difference existed between groups regarding clinical characteristics and metabolic profile. In the liposuction group, the increase in insulin sensitivity was (3.8+/-0.86, 3.1+/-0.85, 4.5+/-1.02 %/min, P=0.08. Insulin sensitivity did not correlate with subcutaneous fat, leptin, or TNFalpha. Leptin diminished at 1 month (52.7+/-6.04 vs 31.6+/-11.9), P=0.028, and correlated with the subcutaneous fat (r=0.957). In the diet-only group, TNFalpha diminished at 6 months, P=0.046.
  
  
  CONCLUSIONS
  Subcutaneous abdominal fat correlates with leptin; nevertheless, it is a weak marker for TNFalpha and insulin sensitivity.
authors: Medical Research Unit in Clinical Epidemiology, Medical Unit of High Specialty, Mexican Institute of Social Security, Guadalajara, Mexico. durun@megared.net.mx
authors: José Antonio
authors: JA
authors: Robles-Cervantes
authors: Esperanza
authors: E
authors: Martínez-Abundis
authors: Manuel
authors: M
authors: González-Ortiz
authors: Lázaro
authors: L
authors: Cárdenas-Camarena
authors: Eduardo
authors: E
authors: Hernández-Salazar
authors: Rafael
authors: R
authors: Olvera-Ozuna
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D015187:Lipectomy; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000601:surgery*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha