title: Synthesis and biological evaluation of bengacarboline derivatives.
abstract: Novel derivatives of the marine alkaloid bengacarboline have been synthesized. The seco derivatives 11 and 12 were evaluated for topoisomerase inhibition, DNA damages, cytotoxicity and cell cycle perturbation. The two synthetic analogs are more potent cytotoxic agents than bengacarboline and they both induce an accumulation of cells in the S phase of DNA synthesis. They do not function as topoisomerase inhibitors but trigger DNA damages in cells.
authors: Laboratoire de Chimie des Procédés et des Substances Naturelles, ICMMO, UMR8182, Université de Paris-sud 11, 91405 Orsay, France.
authors: Annie
authors: A
authors: Pouilhès
authors: Cyrille
authors: C
authors: Kouklovsky
authors: Yves
authors: Y
authors: Langlois
authors: Jean-Pierre
authors: JP
authors: Baltaze
authors: Stéphane
authors: S
authors: Vispé
authors: Jean-Philippe
authors: JP
authors: Annereau
authors: Jean-Marc
authors: JM
authors: Barret
authors: Anna
authors: A
authors: Kruczynski
authors: Christian
authors: C
authors: Bailly
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D059005:Topoisomerase II Inhibitors; D014561:Urochordata / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; D059005:Topoisomerase II Inhibitors; C527225:bengacarboline