title: Optical tweezers as a probe for oligodeoxyribonucleotide structuration.
abstract: The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.
authors: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Faculty of Pharmacy, via Domenico Montesano 49, Naples 80131, Italy. borbone@unina.it
authors: Nicola
authors: N
authors: Borbone
authors: Giorgia
authors: G
authors: Oliviero
authors: Jussara
authors: J
authors: Amato
authors: Gennaro
authors: G
authors: Piccialli
authors: Luciano
authors: L
authors: Mayol
authors: Lisa
authors: L
authors: Miccio
authors: Giuseppe
authors: G
authors: Pescen
authors: Antonio
authors: A
authors: Sasso
mesh_terms: D001483:Base Sequence; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D052898:Optical Tweezers; D012996:Solutions; D014783:Viscosity
chemical_list: D009838:Oligodeoxyribonucleotides; D012996:Solutions