Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics.
The endogenous circadian pacemaker influences key physiologic functions, such as body temperature and heart rate, and is normally synchronized with the sleep/wake cycle. Epidemiological studies demonstrate a 24-h pattern in adverse cardiovascular events with a peak at approximately 10 a.m. It is unknown whether this pattern in cardiac risk is caused by a day/night pattern of behaviors, including activity level and/or influences from the internal circadian pacemaker. We recently found that a scaling index of cardiac vulnerability has an endogenous circadian peak at the circadian phase corresponding to approximately 10 a.m., which conceivably could contribute to the morning peak in cardiac risk. Here, we test whether this endogenous circadian influence on cardiac dynamics is caused by circadian-mediated changes in motor activity or whether activity and heart rate dynamics are decoupled across the circadian cycle. We analyze high-frequency recordings of motion from young healthy subjects during two complementary protocols that decouple the sleep/wake cycle from the circadian cycle while controlling scheduled behaviors. We find that static activity properties (mean and standard deviation) exhibit significant circadian rhythms with a peak at the circadian phase corresponding to 5-9 p.m. ( approximately 9 h later than the peak in the scale-invariant index of heartbeat fluctuations). In contrast, dynamic characteristics of the temporal scale-invariant organization of activity fluctuations (long-range correlations) do not exhibit a circadian rhythm. These findings suggest that endogenous circadian-mediated activity variations are not responsible for the endogenous circadian rhythm in the scale-invariant structure of heartbeat fluctuations and likely do not contribute to the increase in cardiac risk at approximately 10 a.m.
Ivanov
Plamen Ch
PCh
Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA.
Hu
Kun
K
Hilton
Michael F
MF
Shea
Steven A
SA
Stanley
H Eugene
HE
D000328:Adult; D001683:Biological Clocks; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000209:etiology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008954:Models, Biological; D009043:Motor Activity; D012306:Risk; D012890:Sleep; D013997:Time Factors