title: PdCl2/NaI-catalyzed homodimeric coupling-cyclization reaction of 2,3-allenols: an efficient synthesis of 4-(1',3'-dien-2'-yl)-2,5-dihydrofuran derivatives.
abstract: A PdCl2/NaI-catalyzed homodimeric coupling-cyclization reaction of 2,3-allenols was observed to provide an efficient route to 4-(1',3'-dien-2'-yl)-2,5-dihydrofuran derivatives. By using the easily available optically active starting materials, 2,5-dihydrofurans with high enantiopurity may be prepared. A Pd(II)-catalyzed mechanism was also discussed.
authors: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China.
authors: Youqian
authors: Y
authors: Deng
authors: Yihua
authors: Y
authors: Yu
authors: Shengming
authors: S
authors: Ma
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012974:Sodium Iodide / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000466:Alkadienes; D005663:Furans; D010165:Palladium; D012974:Sodium Iodide; C008756:palladium chloride