title: [Analyses of differential expression of Homeobox genes between lingual squamaous cell carcinoma and normal mucosa].
abstract: OBJECTIVE
  To investigate the differently expressed Homeobox genes between lingual squmaous cell carcinoma and normal mucosa.
  
  
  METHODS
  Seven paired specimens including lingual squmaous cell carcinoma and its surrounding normal tissue were obtained from 7 patients. Customized Oligo microarray which contains numerous probes of 232 human Homeobox genes was used to analyse the results. All datas were scanned by Agilent scanner and differentiately expressed genes were sorted out.
  
  
  RESULTS
  Homeobox gene NANOG was found up-regulated in 5 samples. PHTF2 was found down-regulated in 7 samples, and CRX, PITX1, OTEX was found down-regulated in 5 samples.
  
  
  CONCLUSIONS
  As the key gene to cellular proliferation and differentiation, Homeobox genes is closely releverant to the oncogenesis of lingual squmaous cell carcinoma.
authors: Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu, China.
authors: Yuan-ding
authors: YD
authors: Huang
authors: Ye-xiang
authors: YX
authors: Huang
authors: Long-jiang
authors: LJ
authors: Li
authors: Hui
authors: H
authors: Xia
authors: Yu-ming
authors: YM
authors: Wen
mesh_terms: D002454:Cell Differentiation; D015972:Gene Expression Regulation, Neoplastic; D005801:Genes, Homeobox; D006801:Humans; D009092:Mucous Membrane