title: Successful ABO incompatible living donor liver transplantation in a patient with high isoagglutinin titer using high-dose intravenous immunoglobulin.
abstract: The optimal management in living donor liver transplantation using an ABO incompatible donor with a high isoagglutinin titer is still uncertain. Our patient was a 20-year-old woman with fulminant hepatitis. The only available donor was her 54-year-old father-in-law of an incompatible blood type. The initial isoagglutinin titer was 2048x. She received 375 mg/m2 of anti-CD20 antibody 3 days before the living donor liver transplantation with concomitant splenectomy. Despite daily plasma exchanges after transplantation, the isoagglutinin titer started to shoot up to its maximum value of 2048x, with a sudden decline in the bile output. High-dose intravenous immunoglobulin (0.6 g/kg) was given after the plasma exchanges; thereafter, her liver function tests stabilized without a further increase in the isoagglutinin titer. We showed the effectiveness of high-dose intravenous immunoglobulin for the management of the rebound elevation of isoagglutinin titer. The combination of anti-CD20 antibody and daily plasma exchanges seemed ineffective for such a situation. This strategy might be another management option for ABO incompatible liver transplantation.
authors: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka Japan. tikesurg@yahoo.co.jp
authors: T
authors: T
authors: Ikegami
authors: A
authors: A
authors: Taketomi
authors: Y
authors: Y
authors: Soejima
authors: T
authors: T
authors: Iguchi
authors: K
authors: K
authors: Sanefuji
authors: H
authors: H
authors: Kayashima
authors: T
authors: T
authors: Yoshizumi
authors: N
authors: N
authors: Harada
authors: Y
authors: Y
authors: Maehara
mesh_terms: D000017:ABO Blood-Group System; D000208:Acute Disease; D000328:Adult; D000373:Agglutinins / Q000097:blood*; D001787:Blood Group Incompatibility; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D000373:Agglutinins; D016756:Immunoglobulins, Intravenous