title: Tibial pseudotumor in a child with hemophilia.
abstract: Hemophilic pseudotumor is an uncommon complication seen in approximately 1-2% of patients with severe hemophilia. Hemophilic pseudotumors are distinguished into two subdivisions based on location, proximal or distal. Plain x-rays and CT are useful in diagnosis, but MR imaging is the diagnostic test of choice because of its sensitivity to the various blood products. The choice of therapy depends on many parameters, such as the size of the tumor, the age of the patient, and the relation with underlying organs. In most cases of asymptomatic hemophilic pseudotumor, conservative treatment with administration of missing factor as well as immobilization is recommended. The authors describe a 13-year-old boy with severe hemophilia A, who presented with a tibial pseudotumor a few months after an injury. He was conservatively treated for a long period, with daily administration of recombinant factor VIII. His clinical condition improved shortly after therapy induction, but radiological improvement has been moderate. Case history, imaging findings, and therapeutic options are discussed.
authors: Hippokration General Hospital of Thessaloniki, 1st Paediatric Department of Aristotle University of Thessaloniki, Thessaloniki, Greece. Chatzipa@med.auth.gr
authors: Emmanouil S
authors: ES
authors: Hatzipantelis
authors: Miranda
authors: M
authors: Athanassiou-Metaxa
authors: Afroditi
authors: A
authors: Koussi
authors: Ioanna
authors: I
authors: Tsatra
authors: Maria
authors: M
authors: Badouraki
authors: Ioannis
authors: I
authors: Tsayias
authors: Nikolaos
authors: N
authors: Gombakis
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000008:administration & dosage; D006467:Hemophilia A / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013977:Tibia / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: C078147:F8 protein, human; D005169:Factor VIII