title: The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis.
abstract: Recently published genetic studies in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms. An important role for the IL-12/IL-23 pathway in multiple sclerosis (MS) is supported by immunologic studies in patients and animal models. To determine whether IL12B/IL23R disease-associated polymorphisms play a role in susceptibility to MS, we genotyped 910 MS-nuclear families, totaling 3132 individuals. Family-based association analysis was performed. There was no evidence of transmission distortion of any of the tested alleles in this data set.
authors: Celera, Alameda, CA, USA.
authors: Ann B
authors: AB
authors: Begovich
authors: Monica
authors: M
authors: Chang
authors: Stacy J
authors: SJ
authors: Caillier
authors: David
authors: D
authors: Lew
authors: Joseph J
authors: JJ
authors: Catanese
authors: Joanne
authors: J
authors: Wang
authors: Stephen L
authors: SL
authors: Hauser
authors: Jorge R
authors: JR
authors: Oksenberg
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*
chemical_list: C500879:IL12B protein, human; C515500:IL23R protein, human; D053762:Interleukin-12 Subunit p40; D018123:Receptors, Interleukin