Quinolone resistance among Shigella spp. isolated from travellers returning from India.
Among 200 isolates of Shigella from patients with travellers' diarrhoea, 12 isolates (four isolated in 1995-2000 and eight in 2001-2004) exhibited quinolone resistance. Nine of these isolates originated from India. These resistant isolates had at least one amino-acid substitution in GyrA. Quinolone resistance is increasing in Shigella spp. causing travellers' diarrhoea, and particularly among isolates causing diarrhoea in travellers returning from India.
Mensa
L
L
Centre de Recerca en Salut Internacional, CRESIB, IDIBAPS, Barcelona, Spain.
Marco
F
F
Vila
J
J
Gascón
J
J
Ruiz
J
J
D019943:Amino Acid Substitution / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D027081:DNA Gyrase / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000382:microbiology*; D006801:Humans; D007194:India; D015363:Quinolones / Q000494:pharmacology*; D012760:Shigella / Q000187:drug effects* / Q000302:isolation & purification; D014195:Travel
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D027081:DNA Gyrase