title: A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: structure, semi-synthesis, and cytotoxicity.
abstract: A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubia cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 microg/mL.
authors: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors: Ji-Ean
authors: JE
authors: Lee
authors: Yukio
authors: Y
authors: Hitotsuyanagi
authors: Ik-Hwi
authors: IH
authors: Kim
authors: Tomoyo
authors: T
authors: Hasuda
authors: Koichi
authors: K
authors: Takeya
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D045470:Rubia / Q000737:chemistry*
chemical_list: D001643:Bridged Bicyclo Compounds; D009842:Oligopeptides