Thiosugars--derivatization agents for chiral resolution of homoleucines.
o-Phthaldialdehyde was used in combination with a series of six thiosugars for the pre-column chiral derivatization of selected primary amino acids. The diastereomers were resolved on a conventional reversed-phase column and with fluorescence detection. A surprisingly effective resolution of 1-isoindolyl-(1-thioglycosides) derived from 1-thio-beta-L-fucose was observed.
Zahradnícková
Helena
H
Biology Centre, Institute of Entomology, Department of Analytical Biochemistry, Academy of Sciences of the Czech Republic, Ceské Budejovice, Czech Republic. helenaz@bclab.eu
Jegorov
Alexandr
A
Trnka
Tomás
T
Zelenka
Karel
K
D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D054330:Thiosugars / Q000737:chemistry*
D054330:Thiosugars; D007930:Leucine