Thermo-responsive porous membranes of controllable porous morphology from triblock copolymers of polycaprolactone and poly(N-isopropylacrylamide) prepared by atom transfer radical polymerization.
Stimuli-responsive polymers are of crucial importance in the design of smart biomaterials. The thermo-responsive triblock copolymers of polycaprolactone (PCL) and poly( N-isopropylacrylamide) (P(NIPAAm)), or P(NIPAAm)- b-PCL- b- P(NIPAAm) copolymers, were synthesized in this work via atom transfer radical polymerization (ATRP). The P(NIPAAm)- b-PCL- b-P(NIPAAm) copolymers were cast by phase inversion in water into porous membranes with well-defined and uniformly distributed pores. The P(NIPAAm) content in the P(NIPAAm)- b-PCL- b- P(NIPAAm) copolymers and the temperature of the aqueous medium for phase inversion could be used to control the pore size and porosity of the membranes. The thermo-responsive characteristics of the membranes were illustrated in the controlled water uptake and temperature-dependent glucose transport through the membranes. These temperature-sensitive membranes with controllable morphology have potential applications in biomedical engineering, drug delivery, and tissue engineering.
Xu
F J
FJ
Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260.
Li
J
J
Yuan
S J
SJ
Zhang
Z X
ZX
Kang
E T
ET
Neoh
K G
KG
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D008567:Membranes, Artificial; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D000178:Acrylamides; D000180:Acrylic Resins; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; C052970:poly-N-isopropylacrylamide