[Influence of orthodontic force on osteoprotegerin and osteoprotegerin ligand mRNA expression in the inflammatory periodontal tissues].
OBJECTIVE
To explore certain principle of how osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) take part in the periodontal tissues remodeling under the combined influence of inflammation and orthodontic force.


METHODS
The positive signals of OPG and OPGL mRNA were measured with in situ hybridzation after orthodontic tooth movement in the experimental periodontitis groups and control ones.


RESULTS
The OPG and OPGL mRNA expression intensity in the experimental group showed difference from control. All their optical density index reached a peak in day 2, respectively.


CONCLUSIONS
OPG and OPGL play important roles in the periodontal reconstruction induced by inflammation irritation and orthodontic force, and complex interaction could exist between the two factors.
Xiao
Li-wei
LW
Center of Stomatology of the Second Xiangya Hospital, Central South University, Changsha, China.
Chen
Yang-xi
YX
Bai
Ding
D
D006801:Humans; D053244:Osteoprotegerin; D010518:Periodontitis; D053245:RANK Ligand; D012333:RNA, Messenger; D014087:Tooth Movement Techniques
D053244:Osteoprotegerin; D053245:RANK Ligand; D012333:RNA, Messenger