CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women.
BACKGROUND
Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption.


METHODS
A total of 361 women (132 with preeclampsia, 117 with placental abruption and 112 healthy controls) were genotyped for 49A-G polymorphism (dbSNP: rs231775) in the CTLA-4 gene.


RESULTS
The frequency of the G alleles was significantly higher in women with preeclampsia than in controls (51.1% vs. 42.0%; OR 1.44, 95% CI 1.01-3.48, p<0.043). Women with placental abruption had decreased frequency of AA genotype (22.2% vs. 35.7%) and significantly more AG or GG genotypes compared with controls (OR 1.94, 95% CI 1.09-2.07, p<0.024). No significant differences were detected in the frequencies of genotype GG (29.5%, 21.4% and 19.6%, respectively) between the three groups.


CONCLUSIONS
Our data suggest that the 49A-G polymorphism in the CTLA-4 gene is associated with the development of placental abruption and preeclampsia, with women having the G allele being at risk.
Jääskeläinen
Ester
E
Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland.
Toivonen
Sari
S
Keski-Nisula
Leea
L
Paattiniemi
Eeva-Liisa
EL
Helisalmi
Seppo
S
Punnonen
Kari
K
Heinonen
Seppo
S
D000037:Abruptio Placentae / Q000235:genetics*; D015703:Antigens, CD / Q000235:genetics*; D000943:Antigens, Differentiation / Q000235:genetics*; D001483:Base Sequence; D060908:CTLA-4 Antigen; D017931:DNA Primers; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D017931:DNA Primers