The cognitive enhancer T-588 partially compensates the motor associative learning impairments induced by scopolamine injection in mice.
The authors studied the effects of T-588 on scopolamine-induced memory impairments in the acquisition of a classical eyeblink conditioning in behaving adult mice. Mice injected with 0.3 mg/kg of scopolamine showed a marked deficit, compared with nontreated mice, in the acquisition of classical eyeblink conditioning using a trace paradigm. Coadministration of T-588 (0.05% wt/vol, in water) with scopolamine (0.3 mg/kg) significantly prevented this deficit in associative learning. To further assess the effects of T-588 on motor coordination and the cognitive deficits induced by scopolamine, the authors compared adult controls or scopolamine-treated mice in different behavioral tasks: rotarod, object recognition, passive avoidance, and prepulse inhibition. In all of these tasks, the authors found a significant impairment in the motor or cognitive abilities in scopolamine-injected mice, compared with controls. In addition, the coadministration of T-588 with scopolamine restored deficits induced by scopolamine alone. Importantly, the administration of T-588 alone did not evoke any change compared with values obtained for controls. These results suggest that T-588 could be used as a pharmacological agent to improve motor and associative learning disorders.
Eleore
Lyndell
L
Division de Neurociencias, Universidad Pablo de Olavide, Sevilla, Spain.
López-Ramos
Juan C
JC
Yi
Pedro J
PJ
Delgado-García
José M
JM
D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003215:Conditioning, Eyelid / Q000187:drug effects; D004048:Diethylamines / Q000627:therapeutic use*; D004347:Drug Interactions; D004576:Electromyography; D007266:Inhibition, Psychological; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects; D012601:Scopolamine; D013876:Thiophenes / Q000627:therapeutic use*; D013997:Time Factors
D004048:Diethylamines; D013876:Thiophenes; C082372:T 588; D012601:Scopolamine