Association of major depression and binge eating disorder with weight loss in a clinical setting.
OBJECTIVE
Obesity has been linked to both major depressive disorder (MDD) and binge eating disorder (BED) in clinical and epidemiological studies. The present study compared weight loss among patients with and without MDD and BED who participated in a hospital-based weight loss program modeled after the Diabetes Prevention Program.


METHODS
Of 131 obese patients who enrolled in treatment, 17% were diagnosed with MDD only, 13% were diagnosed with BED only, 17% were diagnosed with both MDD and BED, and 53% lacked either diagnosis in a pretreatment clinical interview.


RESULTS
After treatment, patients with MDD only attained 63% of the weight loss that non-depressed patients attained. Patients with BED only attained 55% of the weight loss that non-binge eaters attained. The effect of MDD on weight loss was not accounted for by the presence of BED or vice versa. Only 27% of patients with both MDD and BED achieved clinically significant weight loss compared with 67% of patients who had neither disorder. Results were not significantly altered when gender, age, and diabetes status were adjusted.


CONCLUSIONS
Both MDD and BED were prevalent among this obese clinical population, and each disorder was independently associated with worse outcomes. Research is needed to investigate how to increase the efficacy of behavioral weight loss programs for individuals with MDD and/or BED.
Pagoto
Sherry
S
Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. sherry.pagoto@umassmed.edu
Bodenlos
Jamie S
JS
Kantor
Lyle
L
Gitkind
Mitchell
M
Curtin
Carol
C
Ma
Yunsheng
Y
D000328:Adult; D052018:Bulimia Nervosa / Q000150:complications* / Q000523:psychology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000150:complications* / Q000523:psychology; D019468:Disease Management; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss