title: [Importance of repeat laterally directed sextant prostate biopsy for detection of prostate cancer in high-risk patients].
abstract: Our purpose was to evaluate the relevance of repeat laterally directed sextant prostate biopsy for detection of prostate cancer in high-risk patients.
  
  
  METHODS
  Our study included 195 men at high risk for prostate cancer (elevated prostate-specific antigen level and/or abnormal prostate detected by digital rectal examination). We consulted the patients in outpatient department of Kaunas University of Medicine Hospital during 2003-2007. We performed transrectal ultrasound-guided laterally directed sextant prostate biopsy in every patient. For the patients with benign histological findings and increased risk of prostate cancer, laterally directed sextant biopsies were repeated.
  
  
  RESULTS
  Prostate cancer was detected in 30.3% of patients (59/195) on the first prostate biopsy, in 13.1% (11/84) on the second prostate biopsy, in 10.3% (4/39) on the third, and in 7.7% (1/13) on the forth biopsy. After all biopsies, prostate cancer was detected in 38.5% (75/195) of patients, and it differed significantly from the percentage of prostate cancer cases detected on the first biopsy (30.3%, P=0.04). We detected 78.7% (59/75) of all prostate cancer cases by the first laterally directed sextant prostate biopsy. The rest 21.3% (16/75) of cases we detected by repeat biopsies. The second laterally directed sextant prostate biopsy revealed additional 14.6% (n=11) of prostate cancer cases and increased the detection of prostate cancer to 93.3% (70/75). At the time of the first prostate biopsy, prostate cancer was diagnosed most frequently when patients had both risk factors: elevated prostate-specific antigen level and abnormal digital prostate examination; prostate cancer was diagnosed in 45.3% of these patients. The odds ratio to detect prostate cancer by the first biopsy in patients with elevated prostate-specific antigen level and abnormal digital prostate examination was 3.7, and odds ratio to detect prostate cancer by repeat biopsies was 4.7.
  
  
  CONCLUSIONS
  Repeat ultrasound-guided laterally directed sextant prostate biopsies reveal more cases of prostate cancer as compared to the first prostate biopsy. The majority of prostate cancer cases (93.3%) are detected by the first and second laterally directed sextant prostate biopsies. After the first negative prostate biopsy, we recommend to repeat prostate biopsy in high-risk patients.
authors: Department of Urology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania. kvaic@yahoo.co.uk
authors: Kestutis
authors: K
authors: Vaiciūnas
authors: Stasys
authors: S
authors: Auskalnis
authors: Aivaras
authors: A
authors: Matjosaitis
authors: Antanas
authors: A
authors: Mickevicius
authors: Ramūnas
authors: R
authors: Mickevicius
authors: Darius
authors: D
authors: Trumbeckas
authors: Mindaugas
authors: M
authors: Jievaltas
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D051517:Digital Rectal Examination; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D012307:Risk Factors; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen