Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia.
Isogenic L1 and L2 gene knockout mutants of Stenotrophomonas maltophilia KJ (KJDeltaL1 and KJDeltaL2, respectively) were constructed by xylE gene replacement. Induction kinetics of the L1 and L2 genes were evaluated by testing catechol 2,3-dioxygenase activity in the mutants. The results suggested that the induction of the L1 and L2 genes was differentially regulated.
Hu
Rouh-Mei
RM
Department of Biotechnology and Bioinformatics, Asia University, Taichung 413, Taiwan.
Huang
Kuang-Jay
KJ
Wu
Lii-Tzu
LT
Hsiao
Ying-Ju
YJ
Yang
Tsuey-Ching
TC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D050557:Catechol 2,3-Dioxygenase / Q000378:metabolism; D004790:Enzyme Induction; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA; D020615:Stenotrophomonas maltophilia / Q000201:enzymology* / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D050557:Catechol 2,3-Dioxygenase; C088032:beta-lactamase L1; C425104:beta-lactamase L2; D001618:beta-Lactamases