title: New cycloAmb-nucleoside phosphonate prodrugs.
abstract: cycloSal- and cycloAmb-nucleoside phosphonate prodrugs of PMEA were synthesized and characterized. Each of these compounds showed different disadvantages in hydrolysis. Thus, a new series of cycloAminobenzyl(cycloAmb)-PMEA prodrugs was synthezised and studied with regard to their hydrolysis properties and biological activity.
authors: Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Hamburg, Germany. ulfgoebig@gmx.de
authors: U
authors: U
authors: Görbig
authors: J
authors: J
authors: Balzarini
authors: C
authors: C
authors: Meier
mesh_terms: D006868:Hydrolysis; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009705:Nucleosides; D063065:Organophosphonates; D011355:Prodrugs