Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice.
A new steroidal alkaloid ( 1), together with three known steroidal alkaloids ( 2 - 4), has been isolated from the roots and rhizomes of Veratrum japonicum (Baker) Loes. f.., their structures were established as neogermine ( 1), germine ( 2), germerine ( 3), and neogermbudine ( 4) by means of physicochemical properties and spectroscopic analysis. Compounds 1 - 4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay).
Cong
Yue
Y
Institute of Traditional Chinese Medica, School of Pharmacy, Henan University, Kaifeng, P R China.
Guo
Lei
L
Yang
Jing-Yu
JY
Li
Ling
L
Zhou
Yu-Bo
YB
Chen
Jing
J
Wang
Jin-Hui
JH
D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D027343:Rhizome; D014703:Veratrum
D000470:Alkaloids; D010936:Plant Extracts