Supported synthesis and functionnalization of 2''-deoxyuridine by Suzuki-Miyaura cross-coupling.
The synthesis and modification of 2'-deoxyuridine has been realized under Suzuki-Miyaura palladium-catalyzed cross-coupling conditions. Using Pd(PPh(3))(4) and Na(2)CO(3), 5-iodo-2'-deoxyuridine bound to solid support is coupled with various boronic acids to give 5-(hetero)aryl-2'-deoxyuridine. Pd(PPh(3))(4) palladium catalyzed was found to be superior to Pd(OAc)(2) and (NHC)Pd(allyl)Cl for Suzuki-Miyaura palladium-catalyzed reactions.
El Kazzouli
Saïd
S
Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.
Berteina-Raboin
Sabine
S
Agrofoglio
Luigi A
LA
D001897:Boronic Acids / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D003857:Deoxyuridine / Q000138:chemical synthesis*; D007065:Idoxuridine / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D001897:Boronic Acids; D002254:Carbonates; D009942:Organometallic Compounds; C005686:sodium carbonate; D010165:Palladium; D007065:Idoxuridine; D003857:Deoxyuridine