Potential mechanism for transition between acute hypercapnia during sleep to chronic hypercapnia during wakefulness in obstructive sleep apnea.
This paper presents a series of experiments, both in patients and computer models, investigating the transition from acute to chronic hypercapnia in OSA. The data demonstrate that acute hypercapnia during periodic breathing occurs due to either reduction in magnitude of inter-event ventilation and/or reduction in inter-event ventilatory duration relative to duration of the preceding event. The transition between acute hypercapnia during sleep and chronic sustained hypercapnia during wakefulness may be determined by an interaction between respiratory control and renal handling of HCO3-.
Berger
Kenneth I
KI
NYU School of Medicine, Department of Medicine, USA. kenneth.berger@med.nyu.edu
Norman
Robert G
RG
Ayappa
Indu
I
Oppenheimer
Beno W
BW
Rapoport
David M
DM
Goldring
Roberta M
RM
D002245:Carbon Dioxide / Q000502:physiology; D002908:Chronic Disease; D003198:Computer Simulation; D018450:Disease Progression; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D008168:Lung / Q000502:physiology / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D014851:Wakefulness / Q000502:physiology*
D002245:Carbon Dioxide