title: A doubleheader in endocytosis.
abstract: Synaptojanin1 degrades the signaling lipid phosphatidylinositol-4,5-bisphosphate and facilitates compensatory endocytosis, clathrin-coat disassembly, and vesicle reavailability at active synapses. In this issue of Neuron, Mani et al. provide new information about the separate roles of synaptojanin's two phosphatase domains and its interactions with endophilin in regulating these important aspects of the vesicle cycle.
authors: Graduate Program in Neuroscience, State University of New York, Stony Brook, NY 11794-5230, USA.
authors: George
authors: G
authors: Zanazzi
authors: Gary
authors: G
authors: Matthews
mesh_terms: D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism* / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology
chemical_list: D002966:Clathrin; D009419:Nerve Tissue Proteins; D000217:Acyltransferases; C018764:2-acylglycerophosphate acyltransferase; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases