title: Spontaneous adenocarcinoma immunoreactive to cyclooxygenase-2 and transforming growth factor-beta1 in the buccal salivary gland of a Richardson's ground squirrel (Spermophilus richardsonii).
abstract: The ground squirrel is used as an experimental animal because of its unique biological nature. A 3-year-old female Richardson's ground squirrel developed a mass, 1.5 cm in diameter, in the buccal mucosa. The mass consisted of neoplastic epithelial cells showing acinar, ductular, intraductal papillary, solid, and lobular growth patterns; the cells were immunoreactive to cytokeratin, cyclooxygenase-2 (a marker of malignancy) and TGF-beta1. After resection, the tumor recurred with increased area having a solid or lobular pattern with little differentiation. This tumor was diagnosed as an adenocarcinoma arising from the buccal gland, the first case reported in the ground squirrel. A prominent desmoplastic reaction was present. The interstitial cells reacted to alpha-smooth muscle actin and vimentin, indicating a myofibroblastic nature, presumably induced by epithelial TGF-beta1.
authors: Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
authors: Jyoji
authors: J
authors: Yamate
authors: Emi
authors: E
authors: Yamamoto
authors: Mikoto
authors: M
authors: Nabe
authors: Mitsuru
authors: M
authors: Kuwamura
authors: Daisuke
authors: D
authors: Fujita
authors: Hiroshi
authors: H
authors: Sasai
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D051546:Cyclooxygenase 2 / Q000276:immunology*; D005260:Female; D007150:Immunohistochemistry; D009061:Mouth Mucosa; D012376:Rodent Diseases / Q000276:immunology* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012589:Sciuridae; D053773:Transforming Growth Factor beta1 / Q000276:immunology*
chemical_list: D053773:Transforming Growth Factor beta1; D051546:Cyclooxygenase 2