title: Disruptive behavior as a predictor in Alzheimer disease.
abstract: BACKGROUND
  Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality.
  
  
  OBJECTIVE
  To examine whether the presence of disruptive behavior has predictive value for important outcomes in AD.
  
  
  METHODS
  Using the Columbia University Scale for Psychopathology in Alzheimer Disease (administered every 6 months, for a total of 3438 visit-assessments and an average of 6.9 per patient), the presence of disruptive behavior (wandering, verbal outbursts, physical threats/violence, agitation/restlessness, and sundowning) was extracted and examined as a time-dependent predictor in Cox models. The models controlled for the recruitment cohort, recruitment center, informant status, sex, age, education, a comorbidity index, baseline cognitive and functional performance, and neuroleptic use.
  
  
  METHODS
  Five university-based AD centers in the United States and Europe (Predictors Study).
  
  
  METHODS
  Four hundred ninety-seven patients with early-stage AD (mean Folstein Mini-Mental State Examination score, 20 of 30 at entry) who were recruited and who underwent semiannual follow-up for as long as 14 (mean, 4.4) years.
  
  
  METHODS
  Cognitive (Columbia Mini-Mental State Examination score, < or = 20 of 57 [approximate Folstein Mini-Mental State Examination score, < or = 10 of 30]) and functional (Blessed Dementia Rating Scale score, parts I and II, > or = 10) ratings, institutionalization equivalent index, and death.
  
  
  RESULTS
  At least 1 disruptive behavioral symptom was noted in 48% of patients at baseline and in 83% at any evaluation. Their presence was associated with increased risks of cognitive decline (hazard ratio 1.45 [95% confidence interval (CI), 1.03-2.03]), functional decline (1.66 [95% CI, 1.17-2.36]), and institutionalization (1.47 [95% CI, 1.10-1.97]). Sundowning was associated with faster cognitive decline, wandering with faster functional decline and institutionalization, and agitation/restlessness with faster cognitive and functional decline. There was no association between disruptive behavior and mortality (hazard ratio, 0.94 [95% CI, 0.71-1.25]).
  
  
  CONCLUSIONS
  Disruptive behavior is very common in AD and predicts cognitive decline, functional decline, and institutionalization but not mortality.
authors: Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA. ns257@columbia.edu
authors: Nikolaos
authors: N
authors: Scarmeas
authors: Jason
authors: J
authors: Brandt
authors: Deborah
authors: D
authors: Blacker
authors: Marilyn
authors: M
authors: Albert
authors: Georgios
authors: G
authors: Hadjigeorgiou
authors: Bruno
authors: B
authors: Dubois
authors: Davangere
authors: D
authors: Devanand
authors: Lawrence
authors: L
authors: Honig
authors: Yaakov
authors: Y
authors: Stern
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000523:psychology*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D015331:Cohort Studies; D003643:Death; D005260:Female; D006801:Humans; D007326:Institutionalization; D008297:Male; D009483:Neuropsychological Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011569:Psychiatric Status Rating Scales; D014481:United States / Q000453:epidemiology