Gene expression profiling for improved dissection of acute leukemia: a recently identified immature myeloid/T-lymphoid subgroup as an example.
In this concise overview, we discuss recent findings concerning a distinct subgroup of acute myeloid/T-lymphoid leukemia. We describe how we identified these leukemias in multiple cohorts of acute myeloid leukemia (AML) using a combination of gene expression profiling and additional analytic approaches, and how we obtained insight in possible mechanisms leading to their phenotype.
Wouters
Bas J
BJ
Department of Hematology, Erasmus University Medical Center, Room Ee1342, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Koss
Clara
C
Delwel
Ruud
R
D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic; D020868:Gene Silencing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism*; D015458:Leukemia, T-Cell / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1