title: Unusually large extraintestinal GIST presenting as an abdomino-pelvic tumor.
abstract: BACKGROUND
  Gastrointestinal stromal tumor (GIST) is a rare visceral tumor that may mimic ovarian tumor.
  
  
  METHODS
  A 56-year-old woman presented with a large abdomino-pelvic mass and moderately elevated CA-125. A large tumor occupying the whole abdominal cavity and pelvis was noted on laparotomy. In addition, multiple tumor nodules were seen from the ligament of Treitz to the terminal ileum involving only the surface intestine. The ovaries appeared normal. The tumor demonstrated spindle and epithelioid components and was found to be morphologically and immunohistochemically consistent with GIST.
  
  
  CONCLUSIONS
  Gynecologists need to be cognizant of extra-ovarian pathology in the atypical presentation of a pelvic mass. Correct diagnosis is essential for proper management since GISTs specifically respond to the c-kit selective tyrosine kinase inhibitor, Imatinib mesylate.
authors: Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors: Diana
authors: D
authors: Matteo
authors: Vani
authors: V
authors: Dandolu
authors: Larissa
authors: L
authors: Lembert
authors: Rebecca M
authors: RM
authors: Thomas
authors: Ashwin J
authors: AJ
authors: Chatwani
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D000068877:Imatinib Mesylate; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate