[The role of apoptosis in herpes simplex virus I type myocarditis of mouse].
OBJECTIVE
To explore the relation among apoptosis of myocardial cell and the expression of TGF-beta1 in VMC.


RESULTS
In the experiment, Viral myocarditis (VMC) in BALB/C mouse was obtained by inculating herpes simplex virus I type into abdominal cavity. The rate of VMC was 91.67% after 3 - 35 days of virus infection. The apoptosis (78.33%) and expression of TGF-beta1 (81.76%) were found in the myocardium of infected mouse by TUNEL and immunohistochemical method and electron microscope. AI of myocardial cell was 34.14+/-11.56 - 26.14+/-10.2.


CONCLUSIONS
Apoptosis and expression of TGF-beta1 may participate in occurrence and development of VMC.
Hu
Song-yan
SY
Guangdong Food and Drug Vocational lollege, Guangzhou 510520, China. xho122@yahoo.com.cn
Wang
Xiao-dong
XD
Tang
Xing-shan
XS
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006561:Herpes Simplex / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009205:Myocarditis / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018139:Simplexvirus / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D016212:Transforming Growth Factor beta