Catalase as a source of both X- and V-factor for Haemophilus influenzae.
Haemophilus influenzae requires two growth factors, designated factor X (porphyrin) and factor V (NAD). Mammalian catalases contain both bound heme and NADPH. This study shows that catalase can supply both factors X and V to H. influenzae in vitro, thus representing a potential in vivo source of these essential growth factors.
Morton
Daniel J
DJ
Department of Pediatrics, University of Oklahoma Health Sciences Center, 940 NE 13th Street, Oklahoma City, OK 73104, USA.
VanWagoner
Timothy M
TM
Seale
Thomas W
TW
Whitby
Paul W
PW
Stull
Terrence L
TL
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D002417:Cattle; D006193:Haemophilus influenzae / Q000254:growth & development* / Q000378:metabolism*; D006801:Humans; D009243:NAD / Q000378:metabolism*; D011166:Porphyrins / Q000378:metabolism*
D011166:Porphyrins; D009243:NAD; D002374:Catalase