Hexammineruthenium(III) ion interactions with Z-DNA.
The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.
Bharanidharan
D
D
Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.
Thiyagarajan
S
S
Gautham
N
N
D018360:Crystallography, X-Ray; D043542:DNA, Z-Form / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D017975:Ruthenium Compounds / Q000737:chemistry*
D043542:DNA, Z-Form; D007477:Ions; D017975:Ruthenium Compounds; C031584:hexammineruthenium