Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy.
BACKGROUND
Food-dependent exercise-induced anaphylaxis (FDEIA) is a distinct form of common food allergy characteristically induced by a combination of causative food ingestion and physical exercise. Recent investigations have documented that aspirin consumption, in place of exercise, also induces allergic symptoms.


METHODS
A 63-year-old man began low dose aspirin therapy on September 2005. Since January 2006, he had repeated episodes of generalized urticaria and lost consciousness while he was exercising after eating wheat. He was strongly positive for omega-5 gliadin in a cap-system fluorescent enzyme immunoassay. Therefore, a diagnosis of wheat-dependent exercise-induced anaphylaxis was made.


CONCLUSIONS
Patients with aspirin-provoked FDEIA have been reported previously as taking ordinary doses of aspirin for reducing pain, inflammation and fever. However, in our patient, low dose aspirin therapy for reducing cardiovascular risk possibility induced FDEIA. Growing numbers of elderly people take low doses of aspirin for prevention of cerebral or myocardial infarction. Therefore, physicians should remember that aspirin consumption, even at low doses, is a risk factor for FDEIA.
Fujii
Hiroko
H
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kambe
Naotomo
N
Fujisawa
Akihiro
A
Kohno
Kunie
K
Morita
Eishin
E
Miyachi
Yoshiki
Y
D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D015444:Exercise; D005903:Gliadin / Q000097:blood; D006408:Hematoma, Subdural / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D013575:Syncope / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced; D014715:Vertebrobasilar Insufficiency / Q000188:drug therapy; D021182:Wheat Hypersensitivity / Q000209:etiology*
D007073:Immunoglobulin E; D005903:Gliadin; D001241:Aspirin