title: Acute septic cholelithiasic cholecystitis and adenocarcinoma of the gallbladder; an interesting association.
abstract: OBJECTIVE
  Primary carcinoma of the gallbladder may present as acute lithiasic cholecystitis that leads to severe septic complications. The correlation between severe sepsis of the gallbladder and primary carcinoma is unclear. The goal of the present study is to examine the relation between severe septic complications of lithiasic cholecystitis and primary carcinoma of the gallbladder.
  
  
  METHODS
  A group of 72 patients (22 males, 50 females, age range: 45-99, mean age: 68.6 years), with severe septic cholelithiasic cholecystitis was treated with emergency surgery after failure of conservative treatment, and patients found with primary carcinoma of the gallbladder were registered. The resectability and operability of the tumor were studied, as well as tumor staging and overall patient survival.
  
  
  RESULTS
  During urgent surgery for severe septic lithiasic cholecystitis, 12 patients (12/72, 16.6%) were found with gallbladder carcinoma. Patients with septic acute lithiasic cholecystitis and carcinoma had a higher mean age compared to those without carcinoma (74.8 vs. 67.4 yrs). Eleven of 12 (91.6%) carcinomas were inoperable, despite resectability of 8 out of 12 (66.6%), and overall patient survival was limited to a few months after surgery.
  
  
  CONCLUSIONS
  Severe septic complications in elderly patients with a long-standing history of gallbladder stones may co-exist with primary carcinoma of the gallbladder. The percentage of a gallbladder carcinoma detected in septic patients reaches up to 16.6%. Even if these patients have a poor general health, surgical intervention is a solution when they appear with severe septic clinical symptoms caused by gallstones or carcinoma, in order to avoid lethal sepsis. The possibility of a carcinoma hidden in the gallbladder must be in mind during surgery. Imaging studies before surgery may detect the carcinoma; in most cases carcinomas are inoperable, although colecystectomy may be performed during surgery.
authors: Third Department of Surgery, Athens University Medical School, Athens, Greece. kcharala@cc.uoi.gr
authors: A
authors: A
authors: Charalampopoulos
authors: A
authors: A
authors: Lazaris
authors: E
authors: E
authors: Misiakos
authors: S
authors: S
authors: Liakakos
authors: A
authors: A
authors: Macheras
authors: D
authors: D
authors: Peschos
authors: A
authors: A
authors: Batistatou
authors: K
authors: K
authors: Fotiadis
authors: K
authors: K
authors: Charalabopoulos
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000601:surgery; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002763:Cholecystectomy; D041881:Cholecystitis, Acute / Q000150:complications* / Q000382:microbiology / Q000601:surgery; D041761:Cholecystolithiasis / Q000150:complications* / Q000382:microbiology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000601:surgery; D016905:Gram-Negative Bacterial Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018805:Sepsis / Q000150:complications* / Q000382:microbiology; D013492:Suppuration; D015996:Survival Rate; D016896:Treatment Outcome