title: Microscopic infrared mapping of chloromethylated polystyrene resin beads.
abstract: In solid-phase combinatorial chemistry, analyses are performed using a wide range of analytical techniques ranging from gel-phase nuclear magnetic resonance (NMR) to colorimetric tests to elemental analysis. However, these techniques cannot be used to interrogate functional group distribution at the single-bead level. This paper explores the feasibility of using Fourier transform infrared (FT-IR) microscopy to examine site distribution on chloromethylated polystyrene resin beads and to quantify the loading after coupling with 4-cyanophenol, an IR tagging agent. FT-IR microscopy also provides a unique opportunity to better understand the reactivity of highly cross-linked polymer beads under a range of chemical conditions.
authors: Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
authors: Gurjit S
authors: GS
authors: Mandair
authors: Zhanru
authors: Z
authors: Yu
authors: Nicola
authors: N
authors: Galaffu
authors: Mark
authors: M
authors: Bradley
authors: Andrea E
authors: AE
authors: Russell