title: Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
abstract: Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
authors: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
authors: Kazuaki
authors: K
authors: Miyake
authors: Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.|Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
authors: Yukio
authors: Y
authors: Horikawa
authors: Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Kazuo
authors: K
authors: Hara
authors: Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo, Japan.
authors: Kazuki
authors: K
authors: Yasuda
authors: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Haruhiko
authors: H
authors: Osawa
authors: The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
authors: Hiroto
authors: H
authors: Furuta
authors: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
authors: Yushi
authors: Y
authors: Hirota
authors: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Kazuya
authors: K
authors: Yamagata
authors: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Yoshinori
authors: Y
authors: Hinokio
authors: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Yoshitomo
authors: Y
authors: Oka
authors: Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
authors: Naoko
authors: N
authors: Iwasaki
authors: Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
authors: Yasuhiko
authors: Y
authors: Iwamoto
authors: Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.|Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan.
authors: Yuichiro
authors: Y
authors: Yamada
authors: Kansai Electric Power Hospital, Osaka, Japan.|Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan.
authors: Yutaka
authors: Y
authors: Seino
authors: Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
authors: Hiroshi
authors: H
authors: Maegawa
authors: Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
authors: Atsunori
authors: A
authors: Kashiwagi
authors: Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
authors: Ken
authors: K
authors: Yamamoto
authors: Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Katsushi
authors: K
authors: Tokunaga
authors: Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.
authors: Jun
authors: J
authors: Takeda
authors: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Hideichi
authors: H
authors: Makino
authors: The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
authors: Kishio
authors: K
authors: Nanjo
authors: Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Takashi
authors: T
authors: Kadowaki
authors: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. kasuga@med.kobe-u.ac.jp.
authors: Masato
authors: M
authors: Kasuga
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein