title: Anisotropic imaging performance in breast tomosynthesis.
abstract: We describe the anisotropy in imaging performance caused by oblique x-ray incidence in indirect detectors for breast tomosynthesis based on columnar scintillator screens. We use MANTIS, a freely available combined x-ray, electron, and optical Monte Carlo transport package which models the indirect detection processes in columnar screens, interaction by interaction. The code has been previously validated against published optical distributions. In this article, initial validation results are provided concerning the blur for particular designs of phosphor screens for which some details with respect to the columnar geometry are available from scanning electron microscopy. The polyenergetic x-ray spectrum utilized comes from a database of experimental data for three different anode/filter/kVp combinations: Mo/Mo at 28 kVp, Rh/Rh at 28 kVp, and W/Al at 42 kVp. The x-ray spectra were then filtered with breast tissue (3, 4, and 6 cm thickness), compression paddle, and support base, according to the oblique paths determined by the incidence angle. The composition of the breast tissue was 50%/50% adipose/glandular tissue mass ratio. Results are reported on the pulse-height statistics of the light output and on spatial blur, expressed as the response of the detector to a pencil beam with a certain incidence angle. Results suggest that the response is nonsymmetrical and that the resolution properties of a tomosynthesis system vary significantly with the angle of x-ray incidence. In contrast, it is found that the noise due to the variability in the number of light photons detected per primary x-ray interaction changes only a few percent. The anisotropy in the response is not less in screens with absorptive backings while the noise introduced by variations in the depth-dependent light output and optical transport is larger. The results suggest that anisotropic imaging performance across the detector area can be incorporated into reconstruction algorithms for improving the image quality of breast tomosynthesis. This study also demonstrates that the assessment of image quality of breast tomosynthesis systems requires a more complete description of the detector response beyond local, center measurements of resolution and noise that assume some degree of symmetry in the detector performance.
authors: Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993, USA. aldo.badano@fda.hhs.gov
authors: Aldo
authors: A
authors: Badano
authors: Iacovos S
authors: IS
authors: Kyprianou
authors: Robert J
authors: RJ
authors: Jennings
authors: Josep
authors: J
authors: Sempau
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D016880:Anisotropy; D001940:Breast / Q000473:pathology*; D002586:Cesium / Q000494:pharmacology; D004867:Equipment Design; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D007454:Iodides / Q000494:pharmacology; D008327:Mammography / Q000295:instrumentation*; D009010:Monte Carlo Method; D010758:Phosphorus / Q000737:chemistry; D011856:Radiographic Image Enhancement / Q000295:instrumentation*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D014963:X-Ray Intensifying Screens; D014965:X-Rays
chemical_list: D007454:Iodides; D002586:Cesium; D010758:Phosphorus; C040050:cesium iodide