Paclitaxel release from single and double-layered poly(DL-lactide-co-glycolide)/poly(L-lactide) film for biodegradable coronary stent application.
Our laboratory has been developing a completely biodegradable coronary stent which is made of bilayers of biodegradable polyesters. This article presents the preliminary work done to exploit the drug delivery potential of such a polymeric stent. An antiproliferative drug (paclitaxel) was added either only to the top layer or to both layers and the in vitro release profiles were monitored for up to 90 days. Within 90 days, the measured paclitaxel release was almost entirely from the P(DL)LGA layer. In general, the release profiles show three distinct stages: (a) extremely slow diffusional release, (b) accelerated diffusion-degradation release, and (c) saturation. Separate degradation studies (water absorption, molecular weight reduction, weight loss, and surface topography) were also conducted to better understand the observed release behavior.
Lao
Luciana Lisa
LL
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Venkatraman
Subbu S
SS
D020341:Absorbable Implants; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D054855:Drug-Eluting Stents; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D017239:Paclitaxel / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012995:Solubility; D013499:Surface Properties; D013997:Time Factors
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D011091:Polyesters; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D017239:Paclitaxel