Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent.
A 15-year-old girl was diagnosed with a spinal anaplastic pilocytic astrocytoma. The histologic features were similar to pilocytic astrocytoma WHO grade I, but with an increased mitotic rate, high nuclear pleomorphism, microvascular proliferation, and necrosis. The tumor was subtotally resected and treated with chemotherapy and irradiation. Four years after diagnosis no local progression was seen. At the age of 17, the patient developed a supratentorial primitive neuroectodermal tumor. We report the first case of a primary anaplastic pilocytic astrocytoma and primary primitive neuroectodermal tumor occurring in the same patient.
Blankenburg
Friederike
F
Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. friederike.blankenburg@charite.de
van Landeghem
Frank K H
FK
Plotkin
Michail
M
Henze
Günter
G
von Deimling
Andreas
A
Driever
Pablo Hernáiz
PH
D000293:Adolescent; D001254:Astrocytoma / Q000150:complications / Q000235:genetics / Q000473:pathology*; D003062:Codon; D005091:Exons; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008940:Mitotic Index; D020125:Mutation, Missense; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000235:genetics / Q000473:pathology; D013125:Spinal Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D003062:Codon; D016159:Tumor Suppressor Protein p53