Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin.
Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
Cota
Jason M
JM
University of Texas at Austin College of Pharmacy, UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Grabinski
Jodi L
JL
Talbert
Robert L
RL
Burgess
David S
DS
Rogers
P David
PD
Edlind
Thomas D
TD
Wiederhold
Nathan P
NP
D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000077336:Caspofungin; D002686:Chitin / Q000378:metabolism*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D002686:Chitin; D020928:Mitogen-Activated Protein Kinases; D000077336:Caspofungin