A historical perspective of template-based protein structure prediction.
This chapter presents a broad and a historical overview of the problem of protein structure prediction. Different structure prediction methods, including homology modeling, fold recognition (FR)/protein threading, ab initio/de novo approaches, and hybrid techniques involving multiple types of approaches, are introduced in a historical context. The progress of the field as a whole, especially in the threading/FR area, as reflected by the CASP/CAFASP contests, is reviewed. At the end of the chapter, we discuss the challenging issues ahead in the field of protein structure prediction.
Guo
Jun-Tao
JT
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Ellrott
Kyle
K
Xu
Ying
Y
D000465:Algorithms; D000818:Animals; D030562:Databases, Protein; D049673:History, 20th Century; D006801:Humans; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000266:history*; D040681:Structural Homology, Protein
D011506:Proteins