No evidence of increased risk for certain highly atherogenic lipoprotein phenotypes in HIV-infected patients.
BACKGROUND
There is a need to assess whether human immunodeficiency virus (HIV)-infected patients are more likely than noninfected individuals to have any of the specific lipoprotein combination profiles identified as the best predictors of future cardiovascular disease in the general population.


METHODS
One hundred five infected patients, randomly selected from a Mexican HIV clinic, and 105 age- and gender-matched noninfected community volunteers, were enrolled to study the prevalence of each of three highly atherogenic lipoprotein phenotypes [high apolipoprotein (Apo)B/ApoA-I ratio, hypertriglyceridemia with high ApoB and hypoalphalipoproteinemia with high ApoB], and the relationship between time of exposure to antiretroviral therapy (ART) drug class and lipid changes.


RESULTS
The highly atherogenic lipoprotein phenotypes were similarly frequent in both groups. There was a nonsignificant increased risk of dyslipidemia with longer exposure to any of the ART drug classes, although this hazard seems to be greater in patients with central fat accumulation.


CONCLUSIONS
No evidence of increased risk for certain highly atherogenic lipoprotein phenotypes in HIV-infected patients was found. More than one pathogenic mechanism for ART-associated dyslipidemia is postulated.
Catzin-Kuhlmann
Andrés
A
Department of Medicine, National Institute of Medical Sciences and Nutrition Salvador Zubirán, México, D.F., México.
Castillo-Martínez
Lilia
L
Colín-Ramírez
Eloisa
E
Valles
Victoria
V
Aguilar-Salinas
Carlos A
CA
Sierra
Juan
J
Calva
Juan J
JJ
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis / Q000453:epidemiology; D052456:Hypoalphalipoproteinemias / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D012306:Risk
D019380:Anti-HIV Agents; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B