Computational model of TASK channels and PKC-pathway dependent serotonergic modulatory effects in respiratory-related neurons.
Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors such as 5-HT and pH, can affect HM activities.
Tsao
Tzu-Hsin B
TH
Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, GA, USA.
Butera
Robert J
RJ
D000818:Animals; D007002:Hypoglossal Nerve / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D024683:Potassium Channels, Tandem Pore Domain / Q000187:drug effects / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D024683:Potassium Channels, Tandem Pore Domain; D011985:Receptors, Serotonin; C420132:potassium channel subfamily K member 3; D012701:Serotonin; D011493:Protein Kinase C