title: Altered lipid response in hamsters fed cis-9,trans-11+trans-8,cis-10 conjugated linoleic acid mixture.
abstract: The objective of the present study was to compare the effects of cis-9,trans-11 + trans-8,cis-10 conjugated linoleic acid (CLA) mixture to those of cis-9,trans-11 + trans-10,cis-12 CLA mixture and linoleic acid (LA) on lipoprotein profile, hepatic lipids, body composition and digestibility of dietary fat in hamsters (n = 17) fed diets containing 2% of experimental fat (w/w) for 28 days. The cis-9,trans-11 + trans-10,cis-12 CLA mixture showed higher LDL cholesterol concentrations than LA and the cis-9,trans-11 + trans-8,cis-10 CLA mixture. The cis-9,trans-11 + trans-8,cis-10 CLA mixture induced similar plasma LDL cholesterol and hepatic lipid concentrations, and coefficient of digestibility as LA, indicating no effect of the trans-8,cis-10 CLA isomer on these lipid parameters. On the other hand, the cis-9,trans-11 + trans-8,cis-10 CLA mixture induced higher plasma VLDL cholesterol and triglycerides than LA and the cis-9,trans-11 + trans-10,cis-12 CLA mixture. The cis-9,trans-11 + trans-8,cis-10 CLA mixture also induced the highest plasma glucose concentrations compared with the two other groups, indicating an impairment of glycemic control. No differences in body composition were noted between the three groups. The present results thus show that the cis-9,trans-11 + trans-8,cis-10 CLA mixture can deteriorate plasma VLDL cholesterol and triglycerides in hamsters, possibly due to an increased flux of glucose.
authors: Department of Food Science and Nutrition, Laval University, Quebec, QC, Canada.
authors: Vishnee
authors: V
authors: Bissonauth
authors: P Yvan
authors: PY
authors: Chouinard
authors: Johanne
authors: J
authors: Marin
authors: Nadine
authors: N
authors: Leblanc
authors: Denis
authors: D
authors: Richard
authors: Hélène
authors: H
authors: Jacques
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001835:Body Weight; D008078:Cholesterol, LDL / Q000032:analysis / Q000097:blood; D015243:Cholesterol, VLDL / Q000032:analysis / Q000097:blood; D006224:Cricetinae; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008041:Linoleic Acids / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage* / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008647:Mesocricetus; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D007328:Insulin; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D014280:Triglycerides