title: Effect of platelet-rich plasma on the early bone formation around Ca-P-coated and non-coated oral implants in cortical bone.
abstract: OBJECTIVE
  The purpose of the present study was to investigate the effect of local application of platelet-rich plasma (PRP) on the early healing of cortical bone around Ti implants with two different surface configurations.
  
  
  METHODS
  Six goats were used in this study. PRP fractions were obtained from a venous blood sample of the goats and administered immediately before implant insertion. PRP was applied via gel preparation and installation of the gel into the implant site, or via dipping of the implants in PRP fraction before insertion. A total of 36 implants (18 non-coated and 18 Ca-P-coated) were placed into the tibial cortical bone. The animals were sacrificed at 6 weeks after implantation and implants with surrounding tissue were prepared for histological examination. Histomorphometrical variables like the percentage of implant surface with direct bone-implant contact and the percentage of new and old bone adjacent to the implant were evaluated.
  
  
  RESULTS
  More interfacial bone-to-implant contact was observed for all the three groups of Ca-P-coated implants and the Ti/PRP liquid group. All groups revealed similar percentages of old and new bone adjacent to the implant.
  
  
  CONCLUSIONS
  It was concluded that the additional use of PRP did not have any effect on the early cortical bone response to the Ca-P-coated implants, while PRP in a liquid form showed a tendency to increase bone apposition to roughened titanium implants.
authors: Department of Periodontology & Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors: Dimitris
authors: D
authors: Nikolidakis
authors: Juliette
authors: J
authors: van den Dolder
authors: Joop G C
authors: JG
authors: Wolke
authors: John A
authors: JA
authors: Jansen
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002118:Calcium / Q000627:therapeutic use; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D015921:Dental Implants; D005260:Female; D006041:Goats; D006490:Hemostatics / Q000627:therapeutic use; D010758:Phosphorus / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D013917:Thrombin / Q000627:therapeutic use
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D006490:Hemostatics; D010758:Phosphorus; D013917:Thrombin; D002118:Calcium