Scheduling mammography screening for the early detection of breast cancer in Korean women.
OBJECTIVE
To propose an efficient screening schedule for breast cancer among Korean women using the stochastic model in which the age-specific incidence rate was considered.


METHODS
Female breast cancer data in the Korea Central Cancer Registry 2002.


METHODS
The stochastic model was based on the threshold method, in which the schedule is determined by a pre-specified threshold value. The threshold value was defined as the probability of being in a preclinical state of breast cancer at age 40 years. The sensitivity of the mammography was specified as 0.7. Two models for mean sojourn time (MST) in the preclinical state were considered; MSTs for Model I were 2 (ages < 50 years), 3 (ages 50-59 years), and 4 years (ages > or = 60 years), and MSTs for Model II were 3, 4, and 5 years for the corresponding age groups.


RESULTS
The threshold method for Model I generated 19 examinations within the screening ages of 40-69 years. Each screening time was determined at ages 40.0, 41.6, 43.2, 44.8, 46.0, 47.2, 48.4, 49.6, 50.7, 51.7, 52.7, 53.7, 54.7, 56.2, 57.8, 59.4, 61.3, 63.1, and 64.9 years. The schedule sensitivity of Model I was 64.2%, which was higher than that (57.5%) of the biennial periodic schedule. Model II included 11 screenings between the ages of 40 and 69 years and also showed a higher schedule sensitivity, especially for women aged 40 years as compared with the biennial screening.


CONCLUSIONS
This finding suggests that the threshold screening schedule for breast cancer increase the schedule sensitivity by reflecting the age-specific incidence rate of a population.
Lee
Soon Young
SY
Department of Preventive Medicine and Public Health, School of Medicine, Ajou University, Suwon, Republic of Korea.
Jeong
Seong Hwa
SH
Kim
Jinheum
J
Jung
Sang Hyuk
SH
Song
Keun Bae
KB
Nam
Chung Mo
CM
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001071:Appointments and Schedules; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008327:Mammography / Q000191:economics; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D008875:Middle Aged; D008962:Models, Theoretical; D011230:Precancerous Conditions / Q000175:diagnosis / Q000453:epidemiology; D012680:Sensitivity and Specificity