title: Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice.
abstract: A new steroidal alkaloid ( 1), together with three known steroidal alkaloids ( 2 - 4), has been isolated from the roots and rhizomes of Veratrum japonicum (Baker) Loes. f.., their structures were established as neogermine ( 1), germine ( 2), germerine ( 3), and neogermbudine ( 4) by means of physicochemical properties and spectroscopic analysis. Compounds 1 - 4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay).
authors: Institute of Traditional Chinese Medica, School of Pharmacy, Henan University, Kaifeng, P R China.
authors: Yue
authors: Y
authors: Cong
authors: Lei
authors: L
authors: Guo
authors: Jing-Yu
authors: JY
authors: Yang
authors: Ling
authors: L
authors: Li
authors: Yu-Bo
authors: YB
authors: Zhou
authors: Jing
authors: J
authors: Chen
authors: Jin-Hui
authors: JH
authors: Wang
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D027343:Rhizome; D014703:Veratrum
chemical_list: D000470:Alkaloids; D010936:Plant Extracts