title: New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus.
abstract: Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).
authors: Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.
authors: Keijiro
authors: K
authors: Kito
authors: Ryuhei
authors: R
authors: Ookura
authors: Sanae
authors: S
authors: Yoshida
authors: Michio
authors: M
authors: Namikoshi
authors: Takashi
authors: T
authors: Ooi
authors: Takenori
authors: T
authors: Kusumi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C526623:aspergillide A; C526625:aspergillide B; C526624:aspergillide C