Optical imaging: current applications and future directions.
Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. Whereas optical imaging has been used primarily for research in small-animal models, there are several areas in which optical molecular imaging will translate to clinical medicine. In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine.
Luker
Gary D
GD
University of Michigan, Ann Arbor, Michigan, USA. gluker@umich.edu
Luker
Kathryn E
KE
D000818:Animals; D015510:Clinical Medicine / Q000379:methods*; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D008163:Luminescent Measurements; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology; D055095:Optics and Photonics / Q000295:instrumentation*; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D012984:Software; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods
D003287:Contrast Media; D010447:Peptide Hydrolases