Isonucleosides: design and synthesis of new isomeric nucleosides with antiviral potential.
Isonucleosides discovered in our laboratory have been found to have interesting antiviral activity. The design, development of methodology, and stereochemical synthesis of new isonucleosides of anti-HCV interest are described. Antiviral results are cited.
Nair
Vasu
V
Center for Drug Discovery and the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30620-2352, USA. vnair@rx.uga.edu
Piotrowska
Dorota G
DG
Okello
Maurice
M
Vadakkan
Jean
J
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects; D007536:Isomerism; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D009705:Nucleosides