Efficient synthesis of thymidine boranophosphoramidates conjugated with amino acids.
An efficient synthesis of a thymidine boranophosphoramidate prodrug was accomplished using a phosphoramidite approach in high yield. This new class of compounds is designed to have improved antiviral and anticancer advantages conferred by combining the boranophosphate and normal nucleoside amino acid phosphoramidate. Compounds were characterized by MS and 31P NMR.
Khan
Shoeb I
SI
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA. brshaw@chem.duke.edu
Shaw
Barbara Ramsay
BR
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D000596:Amino Acids; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D013936:Thymidine