Reagents for the selective immobilization of oligonucleotides on solid supports.
New reagents (CPGs and phosphoramidites) for automatic solid phase synthesis of modified oligonucleotides were designed. Three oligonucleotides carrying fluorescent label at the 5'-terminus and an anchor group at the 3'-terminus were prepared and their immobilization in orthogonal conditions on solid supports was studied.
Kvach
Maksim V
MV
Institute of Physical Organic Chemistry NAS, Minsk, Belarus.
Prokhorenko
Igor A
IA
Ustinov
Alexey V
AV
Gontarev
Sergei V
SV
Korshun
Vladimir A
VA
Shmanai
Vadim V
VV
D007202:Indicators and Reagents / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D012685:Sepharose / Q000737:chemistry*
D007202:Indicators and Reagents; D009841:Oligonucleotides; D012685:Sepharose