title: Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion.
abstract: Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.
authors: Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
authors: Katsuhisa
authors: K
authors: Miyake
authors: Masafumi
authors: M
authors: Moriyama
authors: Kumiko
authors: K
authors: Aizawa
authors: Shuji
authors: S
authors: Nagano
authors: Yasushi
authors: Y
authors: Inoue
authors: Atsushi
authors: A
authors: Sadanaga
authors: Hitoshi
authors: H
authors: Nakashima
authors: Seiji
authors: S
authors: Nakamura
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications* / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008882:Mikulicz' Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D010996:Pleural Effusion / Q000150:complications* / Q000166:cytology; D011239:Prednisolone / Q000627:therapeutic use; D018417:Th1 Cells; D018418:Th2 Cells
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone