Identification of the very uncommon allele HLA-Cw*0716 in a Caucasian renal transplant recipient: extension of the exon 4 sequence.
This report describes the unknown exon 4 sequence of the rare human leukocyte antigen-Cw*0716 allele, identified in a Caucasian renal transplant recipient from Italy. This sequence is identical to the Cw*070101 allele, and this result allowed us to confirm the hypothesis of the generation of Cw*0716 allele by an interallelic recombination event between Cw*0701/0706/0718 and Cw*020202 allele.
Canossi
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CNR Institute Organ Transplants and Immunocitology, L'Aquila, Italy. a.canossi@itoi.cnr.it
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D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007558:Italy; D016030:Kidney Transplantation; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D044465:White People / Q000235:genetics*
D015236:HLA-C Antigens; C527711:HLA-C*07:16 antigen