title: Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion.
abstract: OBJECTIVE
  To identify the roles of stromal-derived factor (SDF-1) and inflammatory cytokines in retinal vein occlusion (RVO).
  
  
  METHODS
  Samples were collected by vitrectomy and the levels of SDF-1, vascular endothelial growth factor, and inflammatory cytokines (interleukins [IL-1beta, IL-6, IL-8, IL-10, IL-12p70]; tumor necrosis factor-alpha) were measured in 20 eyes with RVO, and 9 eyes with epiretinal membrane served as negative controls. Four eyes with inflammatory diseases were also investigated.
  
  
  RESULTS
  SDF-1 levels in active RVO (A-RVO; 4 eyes with iris neovascularization) were significantly higher than those in quiescent RVO (Q-RVO; 16 eyes without iris neovascularization) and the negative controls (p < .01), whereas there were no significant difference between the Q-RVO and the negative controls. There were no significant correlations between the concentrations of SDF-1 and other cytokines.
  
  
  CONCLUSIONS
  Elevation of intravitreous SDF-1 levels in A-RVO but not Q-RVO suggested a pivotal role of SDF-1 in angiogenic changes during RVO.
authors: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Yuya
authors: Y
authors: Ki-I
authors: Noboru
authors: N
authors: Arimura
authors: Yoshihiro
authors: Y
authors: Noda
authors: Keita
authors: K
authors: Yamakiri
authors: Norihito
authors: N
authors: Doi
authors: Teruto
authors: T
authors: Hashiguchi
authors: Ikuro
authors: I
authors: Maruyama
authors: Masahiko
authors: M
authors: Shimura
authors: Taiji
authors: T
authors: Sakamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000378:metabolism* / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A