title: Lipoprotein(a) and cardiovascular disease in ethnic Chinese: the Chin-Shan Community Cardiovascular Cohort Study.
abstract: BACKGROUND
  Little is known about lipoprotein(a) [Lp(a)] as a predictor of vascular events among ethnic Chinese. We prospectively investigated the association of Lp(a) with cardiovascular disease and all-cause death in a community-based cohort.
  
  
  METHODS
  We conducted a community-based prospective cohort study of 3484 participants (53% women; age range, 35-97 years) who had complete lipid measurements and were free of a cardiovascular disease history at the time of recruitment. Over a median follow-up of 13.8-years, we documented 210 cases of stroke, 122 cases of coronary heart disease (CHD), and 781 deaths.
  
  
  RESULTS
  The incidences for each event increased appreciably with Lp(a) quartile for stroke and all-cause death, but not for CHD. Baseline Lp(a) concentration by quartile was not significantly associated with stroke, all-cause death, and CHD in multivariate analyses. The multivariate relative risk was significant for stroke at the 90th and 95th percentiles and for total death at the 95th and 99th percentiles.
  
  
  CONCLUSIONS
  Our findings suggest a threshold relationship with little gradient of risk across lower Lp(a) values for stroke and all-cause death in Chinese adults.
authors: Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors: Kuo-Liong
authors: KL
authors: Chien
authors: Hsiu-Ching
authors: HC
authors: Hsu
authors: Ta-Chen
authors: TC
authors: Su
authors: Fung-Chang
authors: FC
authors: Sung
authors: Ming-Fong
authors: MF
authors: Chen
authors: Yuan-Teh
authors: YT
authors: Lee
mesh_terms: D000328:Adult; D044466:Asian People; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000401:mortality; D003327:Coronary Disease / Q000208:ethnology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000208:ethnology*; D015999:Multivariate Analysis; D011446:Prospective Studies; D020521:Stroke / Q000208:ethnology / Q000401:mortality; D013624:Taiwan / Q000453:epidemiology
chemical_list: D017270:Lipoprotein(a)