Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study.
BACKGROUND
Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies.


OBJECTIVE
The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices.


METHODS
Two adiponectin gene (ADIPOQ) SNPs, -11391G>A and -11377C>G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period.


RESULTS
For -11391G>A as well as for -11377C>G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the -11391A (P=0.02) and -11377C (P=0.03) allele over the follow-up of the study. -11391G>A and -11377C>G define haplotypes associated also with WHR measurements and their changes over the follow-up of the study. Diploid configurations that combine -11391A and -11377C were associated with significantly higher WHR changes (DeltaCE: P=0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (P<0.0001).


CONCLUSIONS
In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.
Dolley
G
G
INSERM, U872, Nutriomique (team 7), Cordelier Research Center, Paris, France.
Bertrais
S
S
Frochot
V
V
Bebel
J-F
JF
Guerre-Millo
M
M
Tores
F
F
Rousseau
F
F
Hager
J
J
Basdevant
A
A
Hercberg
S
S
Galan
P
P
Oppert
J-M
JM
Lacorte
J-M
JM
Clément
K
K
D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000368:Aged; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D049629:Waist-Hip Ratio
D052242:Adiponectin