Type I interferon as a stimulus for cross-priming.
Type I interferon (IFN-alpha/beta) is induced rapidly by infection and is well recognised for its crucial role in innate defence. However, it is evident that IFN-alpha/beta also serves as a signal for the generation of adaptive immune responses. In this review, we focus on the involvement of IFN-alpha/beta in the induction of CD8+ T cell responses by cross-priming.
Le Bon
Agnès
A
INSERM U591 - Marie Curie Excellence Team, AVENIR Group, Faculté Necker, 156 rue de Vaugirard, 75015 Paris, France. lebon@necker.fr
Tough
David F
DF
D017951:Antigen Presentation / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D045142:Cross-Priming / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis / Q000502:physiology*; D053633:Receptor, Interferon alpha-beta / Q000502:physiology
D007370:Interferon Type I; D053633:Receptor, Interferon alpha-beta