Synthesis and structural revision of (+/-)-laurentristich-4-ol.
The structure of tetracyclic natural sesquiterpene laurentristich-4-ol was revised based on its synthetic studies. The proposed and the revised structures of laurentristich-4-ol were both synthesized with SmI(2)-mediated ketyl radical cyclization as the key step to construct the spirocyclic ether skeleton.
Chen
Pinhong
P
Joint Laboratory of Green Synthetic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, People's Republic of China.
Wang
Junhua
J
Liu
Kun
K
Li
Chaozhong
C
D003500:Cyclization; D044722:Laurencia / Q000737:chemistry*; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D012717:Sesquiterpenes; C527340:laurentristich-4-ol