title: Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II.
abstract: BACKGROUND
  Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Baseline predictors of temporal BMD changes (DeltaBMD) in AN, including 1) gastrointestinal peptides regulating food intake and appetite that have been related to bone metabolism and 2) bone turnover markers, have not been well characterized. We hypothesized that baseline levels of nutritionally regulated hormones and of bone turnover markers would predict DeltaBMD overall.
  
  
  METHODS
  In a prospective observational study, lumbar and whole-body BMD was measured at 0, 6, and 12 months in 34 AN girls aged 12-18 yr and 33 controls. Baseline body mass index, lean mass, nutritionally regulated hormones [IGF-I, cortisol, ghrelin, leptin, and peptide YY (PYY)], bone formation, and resorption markers were examined to determine nutritional and hormonal predictors of bone density changes.
  
  
  RESULTS
  In a regression model, baseline ghrelin and PYY predicted changes in spine bone measures; and baseline ghrelin, cortisol, and PYY predicted changes in whole-body bone measures independent of baseline nutritional status.
  
  
  CONCLUSIONS
  Neuroendocrine gastrointestinal-derived peptides regulating food intake are independent predictors of changes in bone mass in AN.
authors: Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA. mmisra@partners.org
authors: Madhusmita
authors: M
authors: Misra
authors: Rajani
authors: R
authors: Prabhakaran
authors: Karen K
authors: KK
authors: Miller
authors: Mark A
authors: MA
authors: Goldstein
authors: Diane
authors: D
authors: Mickley
authors: Laura
authors: L
authors: Clauss
authors: Patrice
authors: P
authors: Lockhart
authors: Jennalee
authors: J
authors: Cord
authors: David B
authors: DB
authors: Herzog
authors: Debra K
authors: DK
authors: Katzman
authors: Anne
authors: A
authors: Klibanski
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000378:metabolism*; D015992:Body Mass Index; D015519:Bone Density; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D019894:Peptide YY / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D019894:Peptide YY; D019382:Human Growth Hormone