title: Anthraquinones from the fruits of Vismia laurentii.
abstract: Phytochemical study of the fruits of Vismia laurentii resulted in the isolation of five structurally related compounds. Three of them are constituents, namely, laurentiquinone A (1) (methyl 1,6,8-trihydroxy-3-methyl-7-(3-methylbut-2-enyl)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate), laurentiquinone B (2) (methyl 5,7-dihydroxy-2,2,9-trimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxylate) and laurentiquinone C (3) (methyl 9-(ethanoyloxymethyl)-5,7-dihydroxy-2,2-dimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxylate) and two are known compounds, emodin (4) and isoxanthorin (5). Their structures were elucidated by spectroscopic means. Crude extracts of hexane and EtOAc showed anti-plasmodial activity against the W2 strain of Plasmodium falciparum.
authors: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. didetchamo@yahoo.fr
authors: Diderot Tchamo
authors: DT
authors: Noungoue
authors: Cyril
authors: C
authors: Antheaume
authors: Mehdi
authors: M
authors: Chaabi
authors: Bruno
authors: B
authors: Lenta Ndjakou
authors: Silvère
authors: S
authors: Ngouela
authors: Annelise
authors: A
authors: Lobstein
authors: Etienne
authors: E
authors: Tsamo
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification; D028084:Clusiaceae / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000880:Anthraquinones