title: Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives.
abstract: A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the mostinteresting compound in this series with potential cardiotonic activity.
authors: Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China.
authors: Teng
authors: T
authors: Wang
authors: Ying
authors: Y
authors: Dong
authors: Li-Chen
authors: LC
authors: Wang
authors: Zhen
authors: Z
authors: Chen
mesh_terms: D000818:Animals; D002025:Bufonidae; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006835:Hydrazones / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077464:Simendan; D013329:Structure-Activity Relationship
chemical_list: C525889:6-phenyl-4,5-dihydro-3(2H)-pyridazinone; D002316:Cardiotonic Agents; D006835:Hydrazones; D007202:Indicators and Reagents; D011724:Pyridazines; D000077464:Simendan