title: A novel palladium-catalyzed dicarbonylation process leading to coumarins.
abstract: A novel approach to coumarin derivatives has been developed starting from readily available 2-(1-hydroxyprop-2-ynyl)phenols, based on an unprecedented palladium-catalyzed dicarbonylation process. Reactions were carried out in the presence of catalytic amounts of PdI2 in conjunction with an excess of KI in MeOH as the solvent at room temperature and under 90 atm of CO to give 3-[(methoxycarbonyl)methyl]coumarins in good to high isolated yields (62-87%).
authors: Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende, Cosenza, Italy. b.gabriele@unical.it
authors: Bartolo
authors: B
authors: Gabriele
authors: Raffaella
authors: R
authors: Mancuso
authors: Giuseppe
authors: G
authors: Salerno
authors: Pierluigi
authors: P
authors: Plastina
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D010636:Phenols; D010165:Palladium; D002248:Carbon Monoxide