Toward an artificial aldolase.
A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water.
Font
Daniel
D
Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, E-43007 Tarragona, Spain.
Sayalero
Sonia
S
Bastero
Amaia
A
Jimeno
Ciril
C
Pericàs
Miquel A
MA
D005634:Fructose-Bisphosphate Aldolase / Q000138:chemical synthesis*; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D011137:Polystyrenes; D012997:Solvents; D014230:Triazoles; D014867:Water; D011392:Proline; D005634:Fructose-Bisphosphate Aldolase