Interaction between alpha-linolenic acid-enriched oil and ACE inhibitor concerning the decrease in blood pressure in SHR.
Alpha-linolenic acid (ALA) has been reported to exhibit an antihypertensive effect. Angiotensin-converting enzyme inhibitor (ACEI) is also an antihypertensive agent. We evaluated the interaction between ALA-enriched oil (test oil) and ACEI concerning the decrease in blood pressure by administering test oil, ACEI, or test oil + ACEI to 7-week-old spontaneously hypertensive rats (SHR). After administration, the systolic pressure decreased significantly in all groups compared with the level before administration, but the diastolic pressure decreased significantly only in the test oil + ACEI group. No significant difference was noted in systolic or diastolic pressure among the 3 groups. These results suggest that the interaction between ALA-enriched oil and ACEI is limited. Our study suggested the safety of consuming foods containing a large amount of ALA in combination with hypotensive agents.
Matsuo
Tatsuhiro
T
Faculty of Agriculture, Kagawa University, Kagawa, Japan. matsuo@ag.kagawa-u.ac.jp
Yagi
Kanako
K
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D001794:Blood Pressure / Q000187:drug effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D004336:Drug Antagonism; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017962:alpha-Linolenic Acid / Q000008:administration & dosage* / Q000037:antagonists & inhibitors
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004042:Dietary Fats, Unsaturated; D017962:alpha-Linolenic Acid