Metabolic control of proteasome function.
Proteasomes are major cellular proteases that are important for protein turnover and cell survival. Dysregulation of proteasome is related to many major human diseases. Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation.
Zhang
Fengxue
F
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, USA.
Paterson
Andrew J
AJ
Huang
Ping
P
Wang
Kai
K
Kudlow
Jeffrey E
JE
D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D010766:Phosphorylation; D011480:Protease Inhibitors / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000187:drug effects; D025801:Ubiquitin / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D001786:Blood Glucose; D018696:Neuroprotective Agents; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D025801:Ubiquitin; D017868:Cyclic AMP-Dependent Protein Kinases; D046988:Proteasome Endopeptidase Complex