Dual role of the activated epidermal growth factor receptor in renal tubular cells during stress.
The paper by Sarro et al. raises the therapeutically important possibility that activation of the epidermal growth factor receptor (EGFR) after proximal tubule injury serves an unexpected death function and the EGFR-mediated survival signaling can be restored by identification of parallel and interacting pathways.
Arany
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Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4300 West 7th Street, Little Rock, AR 72205, USA. i.arany@comcast.net
D000818:Animals; D066246:ErbB Receptors / Q000502:physiology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000201:enzymology*; D051379:Mice; D018384:Oxidative Stress
D066246:ErbB Receptors