title: Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates.
abstract: With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad functional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.
authors: Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.
authors: Vincent
authors: V
authors: Roy
authors: Hiroki
authors: H
authors: Kumamoto
authors: Sabine
authors: S
authors: Berteina-Raboin
authors: Steven P
authors: SP
authors: Nolan
authors: Dimitri
authors: D
authors: Topalis
authors: Dominique
authors: D
authors: Deville-Bonne
authors: Jan
authors: J
authors: Balzarini
authors: Johan
authors: J
authors: Neyts
authors: Gracelia
authors: G
authors: Andrei
authors: Robert
authors: R
authors: Snoeck
authors: Luigi A
authors: LA
authors: Agrofoglio
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D002384:Catalysis; D009705:Nucleosides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates; D012428:Ruthenium