title: Increased prevalence of gallstone disease and impaired gallbladder motility in patients with Barrett's esophagus.
abstract: The prevalence of gallstones in patients with Barrett's esophagus (BE) and their gallbladder motility relative to that of healthy volunteers and GERD patients without BE were investigated. Of the 707 patients reviewed, 203 (125 males and 78 females) had BE. The prevalence of gallstones was significantly higher in the patients with BE than in those without BE (34 vs. 20%, respectively). The gallbladder functions of 22 patients with GERD, 27 patients with BE and 21 healthy volunteers were assessed by ultrasonography before and after a test meal. The patients with BE had significantly higher fasting volume and residual volume, but lower ejection volume, ejection fraction and ejection rate values than those of the healthy controls. None of the ultrasonographic parameters of patients without BE were significantly different from those of the controls. Patients with BE have a more complex gastrointestinal motility disorder that involves the gallbladder, and this makes this subset of patients with GERD more prone to gallstone disease.
authors: First Department of Medicine, University of Szeged, Szeged, Hungary. ife@in1st.szote.u-szeged.hu
authors: Ferenc
authors: F
authors: Izbéki
authors: András I
authors: AI
authors: Rosztóczy
authors: John Sebit
authors: JS
authors: Yobuta
authors: Richárd
authors: R
authors: Róka
authors: János
authors: J
authors: Lonovics
authors: Tibor
authors: T
authors: Wittmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D016473:Gallbladder Emptying; D042882:Gallstones / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D014463:Ultrasonography