Tc-99m HMPAO labeled white blood cell imaging in a child with eosinophilic lung disease.
In radiolabeled leukocyte imaging, Tc-99m HMPAO has a significantly higher selectivity for eosinophils than neutrophils, but this may be clinically meaningful in disorders with eosinophilic infiltration. We present the case of a 2-year-old boy with infection who also developed drug-induced eosinophilic lung disease, as established later by bronchoalveolar lavage and discontinuation of the responsible antistaphylococcal agent. In the investigation of sepsis, diffusely increased pulmonary accumulation of Tc-99m HMPAO labeled leukocytes was observed. These findings were consistent with eosinophilic lung infiltration and underline the importance of clinical and laboratory data in the comprehensive interpretation of Tc-99m HMPAO labeled leukocytes scans.
Moralidis
Efstratios
E
Department of Nuclear Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece. emoral@hol.gr
Papakonstantinou
Eugenia
E
Arsos
Georgios
G
Boussios
Nikolaos
N
Koliouskas
Dimitrios
D
Karakatsanis
Constantinos
C
D000081:Acetamides / Q000009:adverse effects; D000890:Anti-Infective Agents / Q000009:adverse effects; D002675:Child, Preschool; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D007962:Leukocytes; D000069349:Linezolid; D008279:Magnetic Resonance Imaging; D008297:Male; D023303:Oxazolidinones / Q000009:adverse effects; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013203:Staphylococcal Infections / Q000188:drug therapy; D019690:Technetium Tc 99m Exametazime
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D000069349:Linezolid