Amyloidosis and vascular thrombosis.
Amyloidosis is a rare systemic disorder of protein metabolism with progressive extra-cellular deposition of insoluble fibrillary protein, disorganization of tissue architecture, and subsequent organ dysfunction. Primary amyloidosis is the most common form of this disorder, however, it can develop secondary to plasma cell dyscrasias such as multiple myeloma (MM); 10-15% of MM patients may develop amyloidosis of vital organs. Amyloidosis is usually associated with bleeding, but less commonly with thrombosis. We present a 52-year-old Saudi female with amyloidosis secondary to multiple myeloma. She presented with both venous and extensive arterial thrombosis. Although relatively rare, plasma cell dyscrasias such as amyloidosis and multiple myeloma could present with thrombotic rather than hemorrhagic complications.
Adamu
Bappa
B
Department of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia. bappakano@yahoo.com
Alshaebi
Fuad
F
Ahmed
Mustafa
M
Beirouti
Bassim
B
D000686:Amyloidosis / Q000150:complications*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001027:Aortography; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D001706:Biopsy; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*
D018906:Antineoplastic Agents, Alkylating; D011239:Prednisolone; D008558:Melphalan