title: Clinicopathological study of invasive ductal carcinoma with large central acellular zone: special reference to magnetic resonance imaging findings.
abstract: Invasive ductal carcinoma (IDC) with central acellular zone is sometimes encountered, but its clinicopathological features have not yet been fully investigated. The clinicopathological features of 10 resected cases of IDC with a large central acellular zone were investigated. The tumor size ranged from 6 to 28 mm with a mean of 14.3 +/- 6.9 mm. Contrast-enhanced magnetic resonance imaging (MRI) showed a ring-like appearance in the tumor. Sagittal fat-suppressed T2-weighted MRI had very high to intermediate signal intensity in a central area. Histologically, cancer tissue was located in the periphery of the tumor with a ring-like pattern and a large central area was occupied by acellular amorphous tissue that was strongly stained by alcian blue. Lymph vessel permeation was seen in eight cases. Among the tumors with focal enhancement in the central areas >1 cm in diameter on contrast MRI, marked increase of microvessel was observed in the enhanced spot. The mean of p53 and Ki-67 labeling indices was 56.2% and 36.3%, respectively. IDC with a large central acellular zone presenting with characteristic MRI should be noted as a new morphological entity.
authors: Kurume University Medical Center, Department of Pathology, Kurume, Japan. rin@med.kurume-u.ac.jp
authors: Rin
authors: R
authors: Yamaguchi
authors: Hidemi
authors: H
authors: Furusawa
authors: Hiroshi
authors: H
authors: Nakahara
authors: Masuko
authors: M
authors: Inomata
authors: Kiyoshi
authors: K
authors: Namba
authors: Maki
authors: M
authors: Tanaka
authors: Kazuaki
authors: K
authors: Ohkuma
authors: Kohsuke
authors: K
authors: Tayama
authors: Teruhiko
authors: T
authors: Fujii
authors: Hirohisa
authors: H
authors: Yano
authors: Masayoshi
authors: M
authors: Kage
authors: Masamichi
authors: M
authors: Kojiro
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D003287:Contrast Media; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53