title: Role of the endocannabinoid system in metabolic control.
abstract: OBJECTIVE
  Growing evidence suggests an important role in metabolic control of the endocannabinoid system, which is composed of cannabinoid receptors, endocannabinoids, and related enzymes. In this short review, we describe the latest advances in this research field, including the antiobesity effect of the cannabinoid receptor CB1 antagonist rimonabant and the anorexic effect of N-oleoylethanolamine, an endocannabinoid-related, endogenous substance.
  
  
  RESULTS
  CB1 is expressed not only in various brain regions, including hypothalamus, but also in peripheral organs such as adipose tissue and liver. The endocannabinoid system appears to function as a physiological system regulating food intake, energy balance, and lipid metabolism through both central and peripheral mechanisms. Obesity may be associated with hyperactivity of the endocannabinoid system. Large phase III trials of rimonabant confirmed significant weight loss and waist circumference reduction in overweight and obese patients. The levels of HDL-cholesterol, triglycerides, and HbA1c were also improved. The anorexic effect of N-oleoylethanolamine was suggested to be mediated by peroxisome proliferator-activated receptor-alpha and the G protein-coupled receptor GPR119.
  
  
  CONCLUSIONS
  These results highlight the importance of an endocannabinoid tone in metabolic control and therapeutic usefulness of CB1 antagonists. Derivatives of N-oleoylethanolamine may be developed as new antiobesity drugs.
authors: Department of Biochemistry, Kagawa University School of Medicine, Kagawa, Japan.
authors: Jun
authors: J
authors: Wang
authors: Natsuo
authors: N
authors: Ueda
mesh_terms: D000855:Anorexia / Q000188:drug therapy; D063385:Cannabinoid Receptor Modulators / Q000737:chemistry / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D063388:Endocannabinoids; D004983:Ethanolamines / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009765:Obesity / Q000188:drug therapy; D009829:Oleic Acids; D010880:Piperidines / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use; D000077285:Rimonabant
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D004983:Ethanolamines; D009829:Oleic Acids; D010880:Piperidines; D011720:Pyrazoles; C033595:N-oleoylethanolamine; D000077285:Rimonabant