Src kinase and pancreatic cancer.
The c-Src non-receptor tyrosine kinase is overexpressed in a large number of human malignancies. It is linked to tumour development and progression to distant metastases by promoting cell proliferation, invasion, and motility. Recently, promising anticancer therapeutics targeting c-Src have been developed that are under clinical investigation.
Hilbig
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Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Germany.
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology*; D010641:Phenotype; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D047428:Protein Kinase Inhibitors; D019061:src-Family Kinases