Cryptococcal glucoxylomannan does not exhibit cross-reactivity in the MVista Histoplasma antigen enzyme immunoassay.
The potential for cross-reaction between Cryptococcus neoformans and Histoplasma capsulatum in antigen assays was evaluated. We tested patient samples, spleens from infected mice, and purified polysaccharides in the MVista Histoplasma antigen enzyme immunoassay and cryptococcal antigen latex agglutination system for cross-reactivity, and none was observed.
Zhuang
David
D
MiraVista Diagnostics, Indianapolis, Indiana 46241, USA.
Hage
Chadi
C
De Jesus
Magdia
M
Hackett
Emily
E
Durkin
Michelle
M
Davis
Thomas E
TE
Casadevall
Arturo
A
Wheat
L Joseph
LJ
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D003429:Cross Reactions; D003453:Cryptococcosis / Q000175:diagnosis*; D003455:Cryptococcus neoformans / Q000276:immunology* / Q000302:isolation & purification; D005936:Glucans / Q000276:immunology*; D006658:Histoplasma / Q000276:immunology* / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D051379:Mice; D012680:Sensitivity and Specificity
D000946:Antigens, Fungal; D005936:Glucans