Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place?
The synthesis of a modified thymidine (nucleoside beta-amino acid) monomer and preliminary investigations into the solid phase peptide synthesis of PNA/DNA chimeras containing a neutral, internucleoside amide linkage are described.
Threlfall
Richard
R
Department of Chemistry, University of Liverpool, Liverpool, United Kingdom. r.threlfall@liv.ac.uk
Davies
Andrew
A
Howarth
Nicola
N
Cosstick
Richard
R
D000596:Amino Acids / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D009705:Nucleosides; D020135:Peptide Nucleic Acids; D004247:DNA