Structural analogs of tylophora alkaloids may not be functional analogs.
Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-kappaB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs.
Gao
Wenli
W
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.
Chen
Annie Pei-Chun
AP
Leung
Chung-Hang
CH
Gullen
Elizabeth A
EA
Fürstner
Alois
A
Shi
Qian
Q
Wei
Linyi
L
Lee
Kuo-Hsiung
KH
Cheng
Yung-Chi
YC
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D031110:Tylophora / Q000737:chemistry*
D000470:Alkaloids