title: [Effects of dressing containing plant sterol on serum cholesterol concentration and the safety evaluation in borderline or mildly hypercholesterolemic Japanese subjects].
abstract: In a placebo-controlled double-blind study, we examined the effects of dressing containing plant sterol (PS) on blood lipids and the safety in Japanese borderline or mildly hypercholesterolemic subjects. Fifty-nine subjects [total cholesterol (TC) concentration > or = 200 mg/dL] were randomly divided into two groups and were given daily 15 g of dressing containing 800 mg of PS [PS(+)-group] or without PS [PS(-)-group] for 12 weeks. Every 4 weeks, fasting blood was examined and subjective symptoms were analyzed. Serum TC, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) concentrations did not change in the PS(-)-group, while TC and ApoB significantly decreased in the PS(+)-group at 8 and 12 weeks and LDL-C at 4, 8 and 12 weeks. Moreover, serum TC, LDL-C and ApoB concentrations were significantly lower than those of PS(-)-group at 8 and 12 weeks. Other laboratory tests were all in normal ranges and no adverse events were observed. The results indicated that PS-containing dressing decreased serum TC, LDL-C and ApoB concentrations in borderline or mildly hypercholesterolemic subjects. It is therefore proved that the dressing containing PS is helpful in maintaining blood cholesterol level normal and hence, the health of Japanese.
authors: R&D Division, Q.P. Corporation, Tokyo, Japan. masanori_kurokawa@kewpie.co.jp
authors: Masanori
authors: M
authors: Kurokawa
authors: Yasunobu
authors: Y
authors: Masuda
authors: Mitsuhiro
authors: M
authors: Noda
authors: Mika
authors: M
authors: Usuda
authors: Sayaka
authors: S
authors: Takeda
authors: Mineo
authors: M
authors: Hasegawa
authors: Yasuhiko
authors: Y
authors: Homma
authors: Michihiro
authors: M
authors: Sugano
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D005503:Food Additives / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007564:Japan; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D005503:Food Additives; D010840:Phytosterols