1E10 anti-idiotype vaccine in non-small cell lung cancer: experience in stage IIIb/IV patients.
Conventional treatment of non-small cell lung cancer (NSCLC) has apparently reached a plateau of effectiveness in improving the survival of the patients. For that reason the search for new therapeutic strategies in this type of tumor is justified. 1E10 is an anti-idiotype murine monoclonal antibody (Ab2 MAb) specific to P3 Ab1 MAb, which reacts with NeuGc-containing gangliosides, sulfatides and with antigens expressed in some tumors, including those from the lung. We report the treatment with aluminum hydroxide-precipitated 1E10 MAb of 34 stage IIIb and 37 stage IV NSCLC patients. These patients were treated with the anti-idiotype vaccine, after received standard chemotherapy and radiotherapy, in a compassionate-use basis study. Patients received five bi-weekly injections of 1 mg of 1E10/Alum, other 10 doses at 28-day intervals and later the patients who maintained a good performance status continued to be immunized at this same time interval. No evidence of unexpected or serious adverse effects was reported. The median survival time of the 56 patients who entered the study with partial response or disease stabilization and with a PS 1 after the first line of chemo/radiotherapy, was 11.50 months from starting vaccination. In contrast, the median survival time calculated for patients who started vaccination with progressive disease and/or a PS2 was 6.50 months.
Alfonso
Saily
S
Celestino Hernández Robau Hospital, Villa Clara, Cuba.
Diaz
Rosa M
RM
de la Torre
Ana
A
Santiesteban
Eduardo
E
Aguirre
Frank
F
Pérez
Kirenia
K
Rodríguez
José L
JL
Barroso
María del Carmen
Mdel C
Hernández
Ana M
AM
Toledo
Darien
D
Gabri
Mariano R
MR
Alonso
Daniel F
DF
Viada
Carmen
C
Gómez
Roberto E
RE
Suárez
Eduardo
E
Vazquez
Ana M
AM
Perez
Rolando
R
Macias
Amparo E
AE
D000276:Adjuvants, Immunologic; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000534:Alum Compounds; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D000888:Antibodies, Anti-Idiotypic; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D005732:Gangliosides; C041524:aluminum sulfate