Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance.
Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 +/- 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 +/- 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 +/- 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.
Reyes
Gissette
G
Departments of Medicine and Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Yasunaga
Koichi
K
Rothenstein
Eileen
E
Karmally
Wahida
W
Ramakrishnan
Rajasekhar
R
Holleran
Stephen
S
Ginsberg
Henry N
HN
D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004035:Diet Therapy; D004075:Diglycerides / Q000008:administration & dosage* / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000178:diet therapy; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D016896:Treatment Outcome
D004075:Diglycerides