title: Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires.
abstract: BACKGROUND
  Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status.
  
  
  METHODS
  We undertook a cross-sectional comparison of scores from two cough-specific health-related quality of life (HRQoL) questionnaires, the Leicester Cough Questionnaire (LCQ), and the Cough Quality of Life Questionnaire (CQLQ), together with a generic HRQoL measure, the EuroQol. Questionnaires were administered to and spirometry performed on 147 outpatients with chronic cough (n = 83), COPD (n = 18), asthma (n = 20), and bronchiectasis (n = 26).
  
  
  RESULTS
  There was no significant difference in the LCQ and CQLQ total scores between groups (p = 0.24 and p = 0.26, respectively). Exploratory analyses of questionnaire subdomains revealed differences in psychosocial issues and functional impairment between the four groups (p = 0.01 and p = 0.05, respectively). CQLQ scores indicated that chronic coughers have more psychosocial issues than patients with bronchiectasis (p = 0.03) but less functional impairment than COPD patients (p = 0.04). There was a significant difference in generic health status across the four disease groups (p = 0.04), with poorest health status in COPD patients. A significant inverse correlation was observed between CQLQ and LCQ in each disease group (chronic cough r = - 0.56, p < 0.001; COPD r = - 0.49, p = 0.04; asthma r = - 0.94, p < 0.001; and bronchiectasis r = - 0.88, p < 0.001). There was no correlation between cough questionnaire scores and FEV(1) in any group, although a significant correlation between EuroQol visual analog scale component and FEV(1) (r = 0.639, p = 0.004) was observed in COPD patients.
  
  
  CONCLUSIONS
  Cough adversely affects health status across a range of common respiratory diseases. The LCQ and CQLQ can each provide important additional information concerning the impact of cough.
authors: Regional Respiratory Centre, The Queen's University of Belfast, Northern Ireland.
authors: Liam
authors: L
authors: Polley
authors: Regional Respiratory Centre, The Queen's University of Belfast, Northern Ireland.
authors: Nurman
authors: N
authors: Yaman
authors: Belfast City Hospital, Respiratory Research Group, The Queen's University of Belfast, Northern Ireland.
authors: Liam
authors: L
authors: Heaney
authors: Department of Epidemiology and Public Health, The Queen's University of Belfast, Northern Ireland.
authors: Chris
authors: C
authors: Cardwell
authors: Department of Radiology, The Queen's University of Belfast, Northern Ireland.
authors: Eimear
authors: E
authors: Murtagh
authors: Department of Radiology, The Queen's University of Belfast, Northern Ireland.
authors: John
authors: J
authors: Ramsey
authors: Regional Respiratory Centre, The Queen's University of Belfast, Northern Ireland.
authors: Joseph
authors: J
authors: MacMahon
authors: Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.
authors: Richard W
authors: RW
authors: Costello
authors: Belfast City Hospital, Respiratory Research Group, The Queen's University of Belfast, Northern Ireland. Electronic address: l.mcgarvey@qub.ac.uk.
authors: Lorcan
authors: L
authors: McGarvey
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000523:psychology; D001987:Bronchiectasis / Q000150:complications* / Q000523:psychology; D002908:Chronic Disease; D003371:Cough / Q000209:etiology* / Q000523:psychology; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000523:psychology; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires