title: Fenestrated occluders for treatment of ASD in elderly patients with pulmonary hypertension and/or right heart failure.
abstract: Atrial septal defect (ASD) occlusion in adult patients with advanced age and left or right heart diastolic or systolic heart failure and in patients with pulmonary arterial hypertension bears a considerable risk of deterioration of heart failure. Therefore, we conducted this feasibility trial in 15 ASD patients with pulmonary hypertension and/or right heart failure using a fenestrated Amplatzer septal occluder (AGA Medical Corporation, Golden Valley, MN), allowing an overflow of blood in both directions in case of univentricular diastolic or systolic heart failure. In all patients, the device could be implanted without complications. All symptomatic patients showed an improvement in the New York Heart Association (NYHA) class, and no right or left heart decompensation occurred. On echocardiography, right ventricular end diastolic dimension (RVEDD) and pulmonary artery pressure (PAP) decreased significantly, whereas left ventricular end diastolic dimension (LVEDD) increased. Our series of 15 patients with fenestrated ASD occlusion shows that high-risk ASD occlusion can safely be accomplished with excellent clinical results and without complications by a fenestrated occluder.
authors: From the Department of Internal Medicine/Cardiology, Unfallkrankenhaus Berlin Academic Teaching Hospital, Berlin, Germany.
authors: Leonhard
authors: L
authors: Bruch
authors: Anne
authors: A
authors: Winkelmann
authors: Steffen
authors: S
authors: Sonntag
authors: Franziska
authors: F
authors: Scherf
authors: Sascha
authors: S
authors: Rux
authors: Marc O
authors: MO
authors: Grad
authors: Franz X
authors: FX
authors: Kleber
mesh_terms: D000367:Age Factors; D000368:Aged; D003971:Diastole; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006344:Heart Septal Defects, Atrial / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014463:Ultrasonography