title: Intranasal midazolam Vs ketamine as premedication in paediatric surgical procedure for child separation and induction.
abstract: In children pre-anaesthetic medications are frequently administered as pharmacological adjunctions to help alleviate the stress and fear of surgery as well as to ease child parental separation and promote a smooth induction. Oral, rectal, intravenous and intramuscular route has been used; however each route has its disadvantage. Pre-anaesthetic medication administered intranasal for avoidance of painful injection have made it a convenient way to pre-medication. To evaluate the efficacy of intranasal administered Midazolam 0.2 mg/kg and Ketamine 5 mg/kg respectively. Total 50 patients of ASA I and II of age group 1- 7 years, mean age 3.88 +/- 1.26 and 4.56 +/- 1.21 were included in group I and group II respectively, and Scheduled for elective surgery. Mean time of separation was 17.12 +/- 1.21 in-group I and 15.68+11.62 in group II with P value < 0.001 and 0.322, shows significant difference during time of separation from parents and no significant difference for i.v. line insertion in both groups.
authors: Department of Anaesthesia, Nepal Medical College Teaching Hospital Jorpati, Kathmandu, Nepal.
authors: Shailendra Nath
authors: SN
authors: Gautam
authors: Shrikrishna
authors: S
authors: Bhatta
authors: Daisy
authors: D
authors: Sangraula
authors: Bishow Chandra
authors: BC
authors: Shrestha
authors: Sharad Bahadur
authors: SB
authors: Rawal
mesh_terms: D000281:Administration, Intranasal; D000778:Anesthetics, Dissociative; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D002673:Child, Hospitalized / Q000523:psychology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D010287:Parent-Child Relations; D011229:Preanesthetic Medication; D011300:Preoperative Care; D013997:Time Factors
chemical_list: D000778:Anesthetics, Dissociative; D014151:Anti-Anxiety Agents; D008874:Midazolam