title: Antioxidant and antiatherogenic activity of cis-Hinokiresinol from Trapa pseudoincisa.
abstract: cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The ICso values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 microM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 microM, respectively.
authors: Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 446-701, Korea.
authors: Myoung-Chong
authors: MC
authors: Song
authors: Hye-Joung
authors: HJ
authors: Yang
authors: Myun-Ho
authors: MH
authors: Bang
authors: Dae-Keun
authors: DK
authors: Kim
authors: Tae-Sook
authors: TS
authors: Jeong
authors: Jong-Pyung
authors: JP
authors: Kim
authors: Nam-In
authors: NI
authors: Baek
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D029561:Lythraceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D064801:Phospholipase A2 Inhibitors
chemical_list: D000975:Antioxidants; D017705:Lignans; D008077:Lipoproteins, LDL; D010636:Phenols; D064801:Phospholipase A2 Inhibitors; C119821:hinokiresinol