Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.
We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.
McGovern
Peter G
PG
Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101-1709, USA. mcgovepg@umdnj.edu
Carson
Sandra A
SA
Barnhart
Huiman X
HX
Myers
Evan R
ER
Legro
Richard S
RS
Diamond
Michael P
MP
Carr
Bruce R
BR
Schlaff
William D
WD
Coutifaris
Christos
C
Cataldo
Nicholas A
NA
Steinkampf
Michael P
MP
Nestler
John E
JE
Gosman
Gabey
G
Leppert
Phyllis C
PC
Giudice
Linda C
LC
D002996:Clomiphene / Q000008:administration & dosage*; D019058:Community Networks; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000188:drug therapy* / Q000453:epidemiology*; D008687:Metformin / Q000008:administration & dosage*; D054582:National Institute of Child Health and Human Development (U.S.); D010349:Patient Compliance / Q000706:statistics & numerical data*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin