Innate host defense functions of secretory leucoprotease inhibitor.
Chronic lung diseases such as cystic fibrosis and emphysema are characterized by a protease burden, an infective process and a dominant proinflammatory profile. Secretory leucoprotease inhibitor (SLPI) is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity. In the course of this review, the authors highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response.
Weldon
Sinead
S
School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland.
Taggart
Clifford C
CC
D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D011014:Pneumonia / Q000276:immunology; D012137:Respiratory System / Q000201:enzymology / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000502:physiology*; D015842:Serine Proteinase Inhibitors / Q000502:physiology
D053481:Secretory Leukocyte Peptidase Inhibitor; D015842:Serine Proteinase Inhibitors