title: Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships.
abstract: TSAO derivatives are a unique group of potent and highly specific inhibitors of HIV-1 replication. We have recently reported 4''-ureido TSAO derivatives that are devoid of anti-HIV-1 activity, but inhibit human cytomegalovirus with an activity comparable to that of Ganciclovir. We herein report the synthesis and biological evaluation of novel 4''-ureido TSAO derivatives in order to evaluate the structural features required for anti-HCMV activity. Interestingly, these studies revealed that the compounds may inhibit HCMV at the DNA polymerase step via a non-nucleoside mechanism.
authors: Instituto de Química Médica (CSIC), Madrid, Spain.
authors: Sonia
authors: S
authors: de Castro
authors: Graziela
authors: G
authors: Andrei
authors: Robert
authors: R
authors: Snoeck
authors: Jan
authors: J
authors: Balzarini
authors: María-José
authors: MJ
authors: Camarasa
authors: Sonsoles
authors: S
authors: Velázquez
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D013141:Spiro Compounds