Genetic differences in airway smooth muscle function.
The genetic basis for airway smooth muscle properties is poorly explored. Contraction and relaxation are altered in asthmatic airway smooth muscle, but the basis for the alterations and the role that muscle-specific susceptibility genes may play is largely unexplored. Alterations in the beta-adrenergic receptor, signaling pathways affecting inositol phosphate metabolism, adenylyl and guanylyl cyclase activity, and contractile proteins such as the myosin heavy chain are all suggested by experimental model systems. Significant changes in proliferative and secretory capacities of asthmatic smooth muscle are also demonstrated, but their genetic basis also requires elucidation. Certain asthma-related genes such as ADAM33, although potentially important for smooth muscle function, have been incompletely explored.
Martin
James G
JG
M.B. B.Ch., Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626 St. Urbain Street, Montréal, PQ, H2X 2P2 Canada. james.martin@mcgill.ca
Jo
Taisuke
T
D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000235:genetics* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D003285:Contractile Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D016210:Methacholine Chloride; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009130:Muscle, Smooth / Q000503:physiopathology*
D003285:Contractile Proteins; D016210:Methacholine Chloride