title: Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds.
abstract: The reactions of arene-metal complexes (arene=p-cymene, benzene or pentamethylcyclopentadienyl, metal=Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(eta5-C10H15)RhCl(pta-Me)2]Cl2, [(eta6-C10H14)OsCl(pta)2]Cl, and [(eta6-C6H6)OsCl2(CH3CN)], are also reported.
authors: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH-1015 Lausanne, Switzerland.
authors: Antoine
authors: A
authors: Dorcier
authors: Christian G
authors: CG
authors: Hartinger
authors: Rosario
authors: R
authors: Scopelliti
authors: Richard H
authors: RH
authors: Fish
authors: Bernhard K
authors: BK
authors: Keppler
authors: Paul J
authors: PJ
authors: Dyson
mesh_terms: D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry*; D011684:Purine Nucleosides / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D009942:Organometallic Compounds; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D009992:Osmium; D012211:Rhenium; D012428:Ruthenium; D004247:DNA