Raft-forming agents: antireflux formulations.
Gastroesophageal reflux disease (GERD) is caused by excessive reflux of gastric content and duodenal bile into the esophagus, and impaired clearance of refluxate from the esophagus. In this perspective, raft-forming antireflux formulations offer better alternatives to the conventional therapies for treatment of uncomplicated GERD. In addition to the alginate-based systems, various natural polysaccharides have generated interest as raft-forming agents because of their bioadhesive/mucoprotective nature. Inclination of current therapy is towards natural products for healing of the disease, which also underlines the market potential of this class, demanding for thorough investigation and development of evaluation methods with better in vitro-in vivo correlation.
Kapadia
Chhanda J
CJ
Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, India. chhandakapadia@rediffmail.com
Mane
Vidya B
VB
D000464:Alginates / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D002245:Carbon Dioxide / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D005685:Galactans / Q000008:administration & dosage; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008351:Mannans / Q000008:administration & dosage; D010368:Pectins / Q000008:administration & dosage; D053149:Plant Gums / Q000008:administration & dosage; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D012624:Seaweed; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D014783:Viscosity
D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D005685:Galactans; D006603:Hexuronic Acids; D008351:Mannans; D053149:Plant Gums; D011135:Polysaccharides, Bacterial; D002245:Carbon Dioxide; D010368:Pectins; D020723:Glucuronic Acid; D017693:Sodium Bicarbonate; C007894:guar gum; C002563:xanthan gum