Lipoprotein(a) and cardiovascular disease in ethnic Chinese: the Chin-Shan Community Cardiovascular Cohort Study.
BACKGROUND
Little is known about lipoprotein(a) [Lp(a)] as a predictor of vascular events among ethnic Chinese. We prospectively investigated the association of Lp(a) with cardiovascular disease and all-cause death in a community-based cohort.


METHODS
We conducted a community-based prospective cohort study of 3484 participants (53% women; age range, 35-97 years) who had complete lipid measurements and were free of a cardiovascular disease history at the time of recruitment. Over a median follow-up of 13.8-years, we documented 210 cases of stroke, 122 cases of coronary heart disease (CHD), and 781 deaths.


RESULTS
The incidences for each event increased appreciably with Lp(a) quartile for stroke and all-cause death, but not for CHD. Baseline Lp(a) concentration by quartile was not significantly associated with stroke, all-cause death, and CHD in multivariate analyses. The multivariate relative risk was significant for stroke at the 90th and 95th percentiles and for total death at the 95th and 99th percentiles.


CONCLUSIONS
Our findings suggest a threshold relationship with little gradient of risk across lower Lp(a) values for stroke and all-cause death in Chinese adults.
Chien
Kuo-Liong
KL
Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Hsu
Hsiu-Ching
HC
Su
Ta-Chen
TC
Sung
Fung-Chang
FC
Chen
Ming-Fong
MF
Lee
Yuan-Teh
YT
D000328:Adult; D044466:Asian People; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000401:mortality; D003327:Coronary Disease / Q000208:ethnology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000208:ethnology*; D015999:Multivariate Analysis; D011446:Prospective Studies; D020521:Stroke / Q000208:ethnology / Q000401:mortality; D013624:Taiwan / Q000453:epidemiology
D017270:Lipoprotein(a)