[Clinico-pathological analysis of 6 cases of post-transplant lymphoproliferative disorders].
OBJECTIVE
To evaluate clinical and pathological features of post-transplant lymphoproliferative disorders (PTLD) and its significance in diagnosis.


METHODS
Six cases of PTLD were studied by light microscope, immunohistochemistry, in-situ hybridization, and gene rearrangement analysis. The clinical and follow-up information were also reviewed.


RESULTS
Among the 6 cases, 3 with monomorphic PTLD were renal transplant recipients, and died 4, 2, and 1 months after diagnosis. 2 were liver transplant recipients, 1 of whom with monomorphic PTLD died 5 months after diagnosis, the other one was diagnosed as early lesion of PTLD and the post-bone marrow transplant case was classified as polymorphic PTLD who survived for 12 months after diagnosis of PTLD. EBER 1/2 DNA was demonstrated in 4 cases.


CONCLUSIONS
PTLD is a lymphoproliferative disease with distinctive morphologic and clinical characteristics after organ transplantation. The prognosis of PTLD correlates with the pathological subtypes and clinical stage.
Wang
Zhao-ming
ZM
Department of Pathology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zheng
Shu-sen
SS
Ding
Wei
W
Wang
Li-jun
LJ
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D011379:Prognosis; D014184:Transplantation, Homologous / Q000473:pathology