title: Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.
abstract: Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.
authors: College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
authors: Lak Shin
authors: LS
authors: Jeong
authors: Long Xuan
authors: LX
authors: Zhao
authors: Won Jun
authors: WJ
authors: Choi
authors: Shantanu
authors: S
authors: Pal
authors: Yeon Hee
authors: YH
authors: Park
authors: Sang Kook
authors: SK
authors: Lee
authors: Moon Woo
authors: MW
authors: Chun
authors: Young B
authors: YB
authors: Lee
authors: Chang Ho
authors: CH
authors: Ahn
authors: Hyung Ryong
authors: HR
authors: Moon
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines