title: Aqueous humor erythropoietin levels in patients with primary open-angle glaucoma.
abstract: OBJECTIVE
  To evaluate the levels of erythropoietin (EPO) in the aqueous humor in eyes with primary open-angle glaucoma (POAG) and without glaucoma.
  
  
  METHODS
  Levels of EPO were measured using a sandwich enzyme-linked immunosorbent assay kit in aqueous humor aspirates taken during anterior segment surgery from 45 patients, of whom 20 had POAG and 25 had senile cataract only.
  
  
  RESULTS
  The mean aqueous humor EPO concentration in eyes with POAG (10.91+/-4.32 mU/mL) was significantly higher than that from eyes with cataract (8.24+/-1.77 mU/mL, P=0.008). There was no significant difference between the serum EPO concentrations of POAG (26.46+/-10.36 mU/mL) and the control group (24.50+/-7.59 mU/mL, P=0.468). There was no correlation (P=0.165) between the EPO aqueous humor concentration and the EPO serum concentration while there was no correlation between the EPO aqueous humor concentration and the EPO serum concentration in the control group (P=0.819).
  
  
  CONCLUSIONS
  The aqueous humor EPO level is increased in eyes with POAG.
authors: Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. tcumurcu@gop.edu.tr
authors: Tongabay
authors: T
authors: Cumurcu
authors: Yunus
authors: Y
authors: Bulut
authors: Helin Deniz
authors: HD
authors: Demir
authors: Gulgun
authors: G
authors: Yenisehirli
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D016022:Case-Control Studies; D002386:Cataract / Q000097:blood / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood / Q000378:metabolism*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D004921:Erythropoietin