[Protection of ulinastatin against myocardial injury induced by off-pump coronary artery bypass graft surgery: report of 24 cases].
OBJECTIVE
To investigate the protective effect of ulinastatin against myocardial injury induced by off-pump coronary artery bypass graft surgery (OPCAB).


METHODS
Twenty-four patients undergoing OPCAB were randomly divided into 2 equal groups: ulinastatin group in which ulinastatin was infused intravenously, firstly at the concentration of 6000 U/kg dissolved in 50 ml normal saline for 30 min and then at the speed of 1000 U.kg(-1).h(-1) up to the end of operation, and control group that underwent infusion of normal saline of the same volume. Blood samples were collected before skin incision, 0.5 h after the completion of vascular anastomosis, and 2, 6, and 18 h after the operation to detect the plasma level of cardiac troponin 1 (cTn1).


RESULTS
The cTn1 levels 2, 6, and 18 h after the operation of both groups were all significantly higher than those before skin incision (all P < 0.01). The cTn1 levels 0.5 h after the completion of vascular anastomosis, and 2, 6, and 18 h after the operation of the ulinastatin group were all significantly lower than those of the control group (all P < 0.01).


CONCLUSIONS
Ulinastatin decreases the cTn1 level that increases peri-operatively, thus reducing the risk of myocardial injury in patients undergoing OPCAB.
Wang
Gu-Yan
GY
Department of Anesthesiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and China Academy of Medical Sciences, Beijing, China.
Qiu
Hong-Bo
HB
Zhan
Shu-Gui
SG
Li
Li-Huan
LH
D000368:Aged; D000369:Aged, 80 and over; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D004311:Double-Blind Method; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D019210:Troponin I / Q000097:blood
D006023:Glycoproteins; D019210:Troponin I; C028665:urinastatin