Efficient C2 functionalisation of 2H-2-imidazolines.
Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).
Bon
Robin S
RS
Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
Sprenkels
Nanda E
NE
Koningstein
Manoe M
MM
Schmitz
Rob F
RF
de Kanter
Frans J J
FJ
Dömling
Alexander
A
Groen
Marinus B
MB
Orru
Romano V A
RV
D000478:Alkylation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D008745:Methylation; D008872:Microwaves; D010084:Oxidation-Reduction; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology
D007093:Imidazoles; D010879:Piperazines; C482203:nutlin 1; C017424:2-imidazoline