title: Off-line fractional exhaled nitric oxide measurement is useful to screen allergic airway inflammation in an adult population.
abstract: To determine whether off-line fractional exhaled nitric oxide (FeNO) measurement is applicable to screen allergic airway inflammation for epidemiologic studies, we examined 280 adults, measuring off-line FeNO samplings, pulmonary function, and serum immunoglobulin E (IgE). Subjects with recurrent wheeze (recurrent wheezers) had significantly higher FeNO and IgE levels and significantly lower forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) than non-wheezers. Statistical analysis showed that FeNO and FEV1/FVC were significant predictors for recurrent wheezers, independent of smoking. The cut-off FeNO level for screening allergic airway inflammation was 38 ppb in non-smokers and 32.9 ppb in smokers. Thus, off-line FeNO can be used as a good marker to screen allergic airway inflammation, regardless of smoking.
authors: Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan. junpei@fmu.ac.jp
authors: Junpei
authors: J
authors: Saito
authors: Suguru
authors: S
authors: Sato
authors: Hideki
authors: H
authors: Hasunuma
authors: Yasushi
authors: Y
authors: Ishimaru
authors: Hiroshi
authors: H
authors: Kanegae
authors: Shoji
authors: S
authors: Kudo
authors: Mitsuru
authors: M
authors: Munakata
mesh_terms: D000328:Adult; D000368:Aged; D045853:Exhalation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D012130:Respiratory Hypersensitivity / Q000378:metabolism*; D012135:Respiratory Sounds
chemical_list: D009569:Nitric Oxide