title: Intracellular trapping of cycloSal-pronucleotides by enzymatic cleavage.
abstract: A new synthesis for cycloSal-pronucleotides bearing enzymatically cleavable triggers is presented. This trigger is introduced to trap the pronucleotide inside cells. The general concept and hydrolysis data in different media are discussed.
authors: Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz, Hamburg, Germany.
authors: H J
authors: HJ
authors: Jessen
authors: V
authors: V
authors: Tonn
authors: C
authors: C
authors: Meier
mesh_terms: D004950:Esterases / Q000378:metabolism*; D006207:Half-Life; D006868:Hydrolysis; D011355:Prodrugs / Q000378:metabolism*; D013942:Thymine Nucleotides / Q000378:metabolism*
chemical_list: D011355:Prodrugs; D013942:Thymine Nucleotides; D004950:Esterases