Roadmap methods for protein folding.
Protein folding refers to the process whereby a protein assumes its intricate three-dimensional shape. This chapter reviews a class of methods for studying the folding process called roadmap methods. The goal of these methods is not to predict the folded structure of a protein, but rather to analyze the folding kinetics. It is assumed that the folded state is known. Roadmap methods maintain a graph representation of sampled conformations. By analyzing this graph one can predict structure formation order, the probability of folding, and get a coarse view of the energy landscape.
Moll
Mark
M
Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Schwarz
David
D
Kavraki
Lydia E
LE
D000818:Animals; D019295:Computational Biology / Q000379:methods; D006801:Humans; D007700:Kinetics; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry; D013816:Thermodynamics
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