title: Genetic disregulation of TNF alpha and TNF alpha type II receptors in colon cancer at the II and III stage of disease.
abstract: The expression of the genes coding TNFalpha and TNF RII receptors (TNF RII: TNFR2 membrane and soluble domain, TNFR2/R7 soluble domain) was analysed in colon cancer at the II and III stage of disease, by estimation of mRNA expression. The study included 80 patients with histopathologically confirmed adenocarcinoma. The number of TNFalpha mRNA, TNFR2 mRNA and TNFR2/R7 mRNA copies were estimated in tumour and healthy tissue. The highest number of mRNA TNF-alpha copies were investigated in all samples of tissue and independently of the stage of disease. Simultaneously, we noticed the largest number of mRNA copies for TNFalpha and TNF R2/R7 in healthy cells at stage III of the disease. It is possible to draw a hypothetical line separating the anti-cancer activity of TNFalpha and its influence on cancer progression.
authors: Department and Teaching Ward of Internal Medicine, Silesian Medical University, Bytom, Poland.
authors: Malgorzata
authors: M
authors: Muc-Wierzgon
authors: Ewa
authors: E
authors: Nowakowska-Zajdel
authors: Teresa
authors: T
authors: Kokot
authors: Andrzej
authors: A
authors: Kozowicz
authors: Andrzej
authors: A
authors: Wiczkowski
authors: Elzbieta
authors: E
authors: Grochowska-Niedworok
authors: Urszula
authors: U
authors: Mazurek
authors: Janusz
authors: J
authors: Wierzgon
mesh_terms: D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha