title: Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
abstract: We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
authors: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
authors: Michael A
authors: MA
authors: van Es
authors: Paul W J
authors: PW
authors: van Vught
authors: Hylke M
authors: HM
authors: Blauw
authors: Lude
authors: L
authors: Franke
authors: Christiaan G J
authors: CG
authors: Saris
authors: Ludo
authors: L
authors: Van den Bosch
authors: Sonja W
authors: SW
authors: de Jong
authors: Vianney
authors: V
authors: de Jong
authors: Frank
authors: F
authors: Baas
authors: Ruben
authors: R
authors: van't Slot
authors: Robin
authors: R
authors: Lemmens
authors: Helenius J
authors: HJ
authors: Schelhaas
authors: Anna
authors: A
authors: Birve
authors: Kristel
authors: K
authors: Sleegers
authors: Christine
authors: C
authors: Van Broeckhoven
authors: Jennifer C
authors: JC
authors: Schymick
authors: Bryan J
authors: BJ
authors: Traynor
authors: John H J
authors: JH
authors: Wokke
authors: Cisca
authors: C
authors: Wijmenga
authors: Wim
authors: W
authors: Robberecht
authors: Peter M
authors: PM
authors: Andersen
authors: Jan H
authors: JH
authors: Veldink
authors: Roel A
authors: RA
authors: Ophoff
authors: Leonard H
authors: LH
authors: van den Berg
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D016022:Case-Control Studies; D002897:Chromosomes, Human, Pair 7; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010447:Peptide Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015221:Potassium Channels / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D015221:Potassium Channels; C503535:DPP6 protein, human; D010447:Peptide Hydrolases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases