Acute hepatitis in adult Still's disease during corticosteroid treatment successfully treated with anakinra.
Adult onset Still's disease (AOSD) is a well-recognized clinical disorder characterized by involvement of various organs, including liver. However, acute hepatitis or hepatic failure is extremely rare, and most of the reported cases occurred during treatment with hepatotoxic drugs. Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Experimental and clinical data support a central role for IL-1Ra in fulminant hepatic failure. We report the case of a patient with AOSD complicated with acute hepatitis during treatment with corticosteroids, which was dramatically improved with anakinra.
Mylona
Eleni
E
5th Department of Internal Medicine, Evangelismos Hospital, 45-47 Hipsilantou Str., Kolonaki, 106 76 Athens, Greece. emylon@med.uoa.gr
Golfinopoulou
Styliani
S
Samarkos
Michael
M
Fanourgiakis
Panagiotis
P
Papadakos
Vasilios
V
Skoutelis
Athanasios
A
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D006505:Hepatitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D011241:Prednisone