title: Semi-quantitation of pulmonary perfusion heterogeneity on respiratory-gated inspiratory and expiratory perfusion SPECT in patients with pulmonary emphysema.
abstract: OBJECTIVE
  Pulmonary perfusion heterogeneity (PPH) in pulmonary emphysema (PE) was semi-quantified by functional lung volume rate (FLVR) curves obtained from respiratory-gated inspiratory and expiratory single-photon emission computed tomography (SPECT).
  
  
  METHODS
  Gated and ungated SPECT were obtained in 36 PE patients [25 with stage IIA and 11 with stage IIB for global initiative for chronic obstructive lung disease (GOLD) stage classification] and 12 controls, using a triple-head SPECT system and a respiratory tracking device. On gated SPECT, the voxel numbers calculated at the 10% cutoff threshold for the maximum lung radioactivity were assumed to be the functional lung volume of the lung (V). FLVR (%) was calculated as FLV divided by V at every additional 10% thresholds, yielding inspiratory and expiratory FLVR curves. The dissociations between these curves (DeltaFLVRinsp-exsp) and the total difference (D index) of these curves from the normal standard curve (averaged inspiratory and expiratory curve in controls) were calculated. D index and the extent of low attenuation area (%LAA) on CT were correlated with the transfer coefficient for carbon monoxide (KCO) in PE patients.
  
  
  RESULTS
  Although gated and ungated SPECT showed fairly uniform perfusion in controls, gated SPECT-enhanced PPH compared with ungated SPECT in PE patients, with significantly higher dissociation (DeltaFLVRinsp-exsp) than that in controls (24.9%+/-9.5% vs. 4.5%+/-1.3%; P<0.0001). DeltaFLVRinsp-exsp was significantly higher even in stage IIA patients (P<0.0001). Expiratory D index was significantly higher than the inspiratory one in PE patients (P<0.01). This index was significantly higher in stage IIB patients than in stage IIA patients (44.1%+/-19.0% vs. 29.4%+/-13.7%; P<0.05), and was significantly correlated with KCO (R=0.642, P<0.0001) in all PE patients, although %LAA was not correlated with KCO.
  
  
  CONCLUSIONS
  FLVR curve analysis on gated SPECT appears useful for semi-quantitation of respiratory change of PPH in PE. Expiratory D index may better reflect the lung pathophysiology of PE than morphologic CT.
authors: Department of Radiology, Semui Cancer Screening and Radiotherapy Site, St. Hill Hospital, 1462-3 Nishikiwa, Ube 755-0151, and Yamaguchi University School of Medicine, Japan.
authors: Yasuhiko
authors: Y
authors: Kawakami
authors: Kazuyoshi
authors: K
authors: Suga
authors: Mohammed
authors: M
authors: Zaki
authors: Hideyuki
authors: H
authors: Iwanaga
authors: Tomio
authors: T
authors: Yamashita
authors: Noriko
authors: N
authors: Hayashi
authors: Naofumi
authors: N
authors: Matsunaga
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D001239:Inhalation; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015656:Respiratory Mechanics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*