title: Relation of baseline plasma phospholipid levels to cardiovascular outcomes at two years in men with acute coronary syndrome referred for coronary angiography.
abstract: In addition to cholesterol and triglycerides, plasma also contains phospholipids. The choline-containing phospholipids constitute >90% of total plasma phospholipids. To date, no studies have looked specifically at the prognostic significance of total phospholipids in patients with known or suspected coronary artery disease. The present study investigated the long-term prognostic significance of total choline-containing phospholipid levels in a well-characterized cohort of 193 men with acute coronary syndromes who were referred for coronary angiography at a Department of Veterans Affairs Medical Center. All patients were followed prospectively for the development of vascular outcomes. After controlling for a variety of baseline variables (including established biomarkers such high-sensitivity C-reactive protein and fibrinogen), plasma phospholipid values (analyzed as a continuous variable) were a strong and independent predictor of each of the individual end points of all-cause mortality (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.41 to 0.90, p = 0.0126), cardiac mortality (HR 0.49, 95% CI 0.29 to 0.81, p = 0.0057), and myocardial infarction (HR 0.71, 95% CI 0.52 to 0.98, p = 0.0342) when using a Cox proportional-hazards model. In addition, baseline phospholipid values were also an independent predictor of the composite outcome of all-cause mortality, fatal or nonfatal myocardial infarction, or stroke (HR 0.66, 95% CI 0.49 to 0.90, p = 0.0075). In conclusion, these data demonstrate that low baseline levels of total choline-containing phospholipid are a strong and independent predictor of cardiovascular outcomes (including mortality) in patients with acute coronary syndromes.
authors: Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA. ecavusoglu@aol.com
authors: Erdal
authors: E
authors: Cavusoglu
authors: Sandeep
authors: S
authors: Chhabra
authors: Xian-Cheng
authors: XC
authors: Jiang
authors: Mohammad R
authors: MR
authors: Hojjati
authors: Vineet
authors: V
authors: Chopra
authors: Calvin
authors: C
authors: Eng
authors: Amit
authors: A
authors: Gupta
authors: Sunitha
authors: S
authors: Yanamadala
authors: David J
authors: DJ
authors: Pinsky
authors: Jonathan D
authors: JD
authors: Marmur
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010743:Phospholipids / Q000097:blood*; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies
chemical_list: D010743:Phospholipids; D005340:Fibrinogen; D002097:C-Reactive Protein