title: The relationship between alcohol consumption and cortisol secretion in an aging cohort.
abstract: BACKGROUND
  Evidence for an association between alcohol consumption and activity of the hypothalamic-pituitary-adrenal (HPA) axis is inconclusive.
  
  
  OBJECTIVE
  Our objective was to assess the relationship between indices of alcohol consumption and salivary cortisol concentration.
  
  
  METHODS
  This was a cross-sectional study of alcohol consumption and cortisol secretion from phase 7 (2002-2004) of the Whitehall II study.
  
  
  METHODS
  An occupational cohort originally recruited in 1985-1987 was included in the study.
  
  
  METHODS
  A total of 2693 men and 977 women had information on cortisol levels and alcohol consumption.
  
  
  METHODS
  Saliva samples were taken on waking, waking+0.5, 2.5, 8, and 12 h, and bedtime for the assessment of cortisol.
  
  
  RESULTS
  In men there was a positive association between cortisol and units of alcohol intake per week (3% increase in cortisol per unit of alcohol consumed; P=0.010). The slope of cortisol decline over the day in heavy drinkers was reduced (heavy drinkers beta=-0.155, moderate drinkers beta=-0.151), indicating reduced control of the HPA axis in heavy drinkers. In women the cortisol awakening response was greater in heavy drinkers 14.15 nmol/liter (9.12-19.17) compared with moderate drinkers 8.69 nmol/liter (7.72-9.67) (P=0.037).
  
  
  CONCLUSIONS
  This study suggests that alcohol consumption is associated with activation of the HPA axis. These results are not due to alcohol consumption on the day, suggesting chronic changes of the HPA axis in heavy drinking groups.
authors: Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, London WC1E 6BT, United Kingdom. e.badrick@ucl.ac.uk
authors: Ellena
authors: E
authors: Badrick
authors: Martin
authors: M
authors: Bobak
authors: Annie
authors: A
authors: Britton
authors: Clemens
authors: C
authors: Kirschbaum
authors: Michael
authors: M
authors: Marmot
authors: Meena
authors: M
authors: Kumari
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000502:physiology
chemical_list: D006854:Hydrocortisone