title: Metabolic and immunological features of the failing islet-transplanted patient.
abstract: OBJECTIVE
  This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure.
  
  
  METHODS
  We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx).
  
  
  RESULTS
  The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure.
  
  
  CONCLUSIONS
  Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.
authors: Department of Medicine, San Raffaele Scientific Institute, Milan, Italy.
authors: Paolo
authors: P
authors: Fiorina
authors: Andrea
authors: A
authors: Vergani
authors: Alessandra
authors: A
authors: Petrelli
authors: Francesca
authors: F
authors: D'Addio
authors: Lucilla
authors: L
authors: Monti
authors: Reza
authors: R
authors: Abdi
authors: Emanuele
authors: E
authors: Bosi
authors: Paola
authors: P
authors: Maffi
authors: Antonio
authors: A
authors: Secchi
mesh_terms: D000328:Adult; D017304:Annexin A5 / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D053222:Fas Ligand Protein / Q000378:metabolism; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D006085:Graft Survival; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016381:Islets of Langerhans Transplantation; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D017304:Annexin A5; D002096:C-Peptide; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007328:Insulin