title: Performance characteristics of microparticle enzyme and chemiluminescence immunoassays for measurement of anti-HBc immunoglobulin M in sera of patients with HBeAg-negative chronic hepatitis B virus infection.
abstract: The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.
authors: Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas. Sophias Ave., Athens 11527, Greece. emhadzi@med.uoa.gr
authors: Emilia
authors: E
authors: Hadziyannis
authors: Emanuel
authors: E
authors: Manesis
authors: Dimitrios
authors: D
authors: Vassilopoulos
authors: Anastasia
authors: A
authors: Georgiou
authors: Athanasios
authors: A
authors: Archimandritis
mesh_terms: D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007124:Immunoenzyme Techniques / Q000379:methods*; D007075:Immunoglobulin M / Q000097:blood*; D049449:Luminescence; D013223:Statistics as Topic
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D007075:Immunoglobulin M