title: Human variability of fMRI brain activation in response to oculomotor stimuli.
abstract: Assessing interindividual variability of brain activation is of practical importance to the use of functional magnetic resonance imaging (fMRI) in the clinical context. The main objective of this study is to analyze the variability of the oculomotor system through horizontal optokinetic, pursuit and saccadic eye movement stimulations by means of fMRI. We found significant activation of many cortical and subcortical structures. The frequency of activation demonstrates a high variability between subjects. However, the most frequent activation regions were located in frontal areas and in regions comprising the middle temporal and medial superior temporal areas. Our study allowed the characterization of the most frequently involved foci in optokinetic stimulation, pursuit and saccadic eye movement tasks. The combination of these tasks constitutes a suitable tool for mapping major areas involved in the oculomotor system.
authors: Departament of Physics and Math, Universidade de Sao Paulo, Av Bandeirantes, 3900, Ribeirao Preto, SP, Brazil.
authors: Hellen M
authors: HM
authors: Della-Justina
authors: Bruno F
authors: BF
authors: Pastorello
authors: Taiza E G
authors: TE
authors: Santos-Pontelli
authors: Octavio M
authors: OM
authors: Pontes-Neto
authors: Antonio Carlos
authors: AC
authors: Santos
authors: Oswaldo
authors: O
authors: Baffa
authors: Jose F
authors: JF
authors: Colafemina
authors: Joao P
authors: JP
authors: Leite
authors: Draulio B
authors: DB
authors: de Araujo
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017120:Nystagmus, Optokinetic / Q000502:physiology; D010775:Photic Stimulation; D012438:Saccades / Q000502:physiology; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology