Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes.
The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.
Borbone
Nicola
N
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via Domenico Montesano 49, Naples 80131, Italy. borbone@unina.it
Oliviero
Giorgia
G
Amato
Jussara
J
D'Errico
Stefano
S
Galeone
Aldo
A
Piccialli
Gennaro
G
Mayol
Luciano
L
D054856:G-Quadruplexes; D006151:Guanosine / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides; D006151:Guanosine