Treatment of neurodegenerative disorders with radical nanomedicine.
In engineering and materials science, nanotechnology has provided many advances that effectively reduce oxidative damage generated by free radical production. Despite such advances, there has been little application to biomedical problems. Increased oxidative stress and free radical production are associated with neurodegenerative conditions, including aging, trauma, Alzheimer's and Parkinson's diseases, and many others. The antioxidant properties of cerium oxide nanoparticles show promise in the treatment of such diseases. Here, we summarize the work on the biological antioxidant actions of cerium oxide nanoparticles in extension of cell and organism longevity, protection against free radical insult, and protection against trauma-induced neuronal damage. We discuss establishment of effective dosing parameters, along with the physicochemical properties that regulate the pharmacological action of these new nanomaterials. Taken together, these studies suggest that nanotechnology can take pharmacological treatment to a new level, with a novel generation of nanopharmaceuticals.
Singh
Neeraj
N
Virginia College of Osteopathic Medicine, Virginia Polytechnic & State University, Blacksburg, VA 24060, USA.
Cohen
Courtney A
CA
Rzigalinski
Beverly A
BA
D000818:Animals; D002563:Cerium / Q000627:therapeutic use*; D005609:Free Radicals / Q000633:toxicity; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000628:therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D005609:Free Radicals; D018696:Neuroprotective Agents; D002563:Cerium; C030583:ceric oxide