Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome.
We here present a case of mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. A 20-year-old Japanese man with a mass in the left inguinal region underwent orchidectomy as a left testicular tumor was suspected. Histology showed a mixed germ-cell tumor with embryonal carcinoma and yolk sac tumor with syncytiotrophoblastic giant cells occurring in a cryptorchid testis. Chromosomal analysis of peripheral lymphocytes disclosed a karyotype of 47,XY,+21[20]. Our case provides further evidence that these three conditions-Down's syndrome, cryptorchidism and testicular germ cell tumor-may be closely associated. To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism.
Kuroda
Naoto
N
Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan.
Amano
Shinji
S
Shiotsu
Tomoyuki
T
Tamura
Masato
M
Hes
Ondrej
O
Michal
Michal
M
Lee
Gang-Hong
GH
D000328:Adult; D003456:Cryptorchidism / Q000150:complications / Q000473:pathology*; D004314:Down Syndrome / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology* / Q000601:surgery; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome