Inhibitory deficits in Tourette's syndrome.
A developmental approach to the study of psychopathology can broaden understanding of a wide variety of complex psychological disorders. This article reviews research on Tourette's syndrome (TS), a developmental disorder characterized by unwanted motor and vocal tics. Over the past decade, knowledge of the neurobiology and pathophysiology of TS has progressed rapidly. The application of brain imaging techniques, primarily magnetic resonance imaging, to the study of Tourette's has increased knowledge of structural and functional deficits in brain areas associated with behavioral and psychological disturbances in the disorder. By reviewing some of this work, we will describe one way in which knowledge of brain function in TS has both informed and been informed by a developmental science approach. In particular, we will consider the extent to which the cognitive and emotional development of persons with TS may be affected by specific neurobiological characteristics of the disorder.
Stern
Emily R
ER
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, 2701 Rachel Upjohn Building, Ann Arbor, MI 48109, USA. emistern@med.umich.edu
Blair
Clancy
C
Peterson
Bradley S
BS
D000339:Affect; D001288:Attention; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time; D005879:Tourette Syndrome / Q000453:epidemiology / Q000503:physiopathology*