Yersinia outer proteins: Yops.
The pathogenic bacteria Yersinia spp. contain a virulence plasmid that encodes a type III secretion system and effectors. During infection, four of the effectors target the actin cytoskeleton, crippling the phagocytic machinery in the infected cell. The remaining two effectors dampen the innate immune response by targeting important signalling pathways. Although the biochemical activity for each of these effectors is known, the mechanisms involved in their ordered secretion and delivery remain elusive.
Trosky
Jennifer E
JE
Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild Science Building, D300, 299 Campus Drive, Stanford, CA 94305-5124, USA.
Liverman
Amy D B
AD
Orth
Kim
K
D001426:Bacterial Proteins / Q000633:toxicity*; D002352:Carrier Proteins / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology; D010957:Plasmids; D015398:Signal Transduction / Q000276:immunology; D014774:Virulence; D015007:Yersinia / Q000276:immunology* / Q000472:pathogenicity*
D001426:Bacterial Proteins; D002352:Carrier Proteins