[Analyses of differential expression of Homeobox genes between lingual squamaous cell carcinoma and normal mucosa].
OBJECTIVE
To investigate the differently expressed Homeobox genes between lingual squmaous cell carcinoma and normal mucosa.


METHODS
Seven paired specimens including lingual squmaous cell carcinoma and its surrounding normal tissue were obtained from 7 patients. Customized Oligo microarray which contains numerous probes of 232 human Homeobox genes was used to analyse the results. All datas were scanned by Agilent scanner and differentiately expressed genes were sorted out.


RESULTS
Homeobox gene NANOG was found up-regulated in 5 samples. PHTF2 was found down-regulated in 7 samples, and CRX, PITX1, OTEX was found down-regulated in 5 samples.


CONCLUSIONS
As the key gene to cellular proliferation and differentiation, Homeobox genes is closely releverant to the oncogenesis of lingual squmaous cell carcinoma.
Huang
Yuan-ding
YD
Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu, China.
Huang
Ye-xiang
YX
Li
Long-jiang
LJ
Xia
Hui
H
Wen
Yu-ming
YM
D002454:Cell Differentiation; D015972:Gene Expression Regulation, Neoplastic; D005801:Genes, Homeobox; D006801:Humans; D009092:Mucous Membrane