Attachment of cholesterol to amino-LNA: synthesis and hybridization properties.
Here, we present our synthesis of amino-LNA with a C6-linker and hybridization studies of these. A cholesterol moiety was attached at the end of the C6-linker. This resulted in drastic drops against DNA of the modified oligonucleotide.
Bryld
Torsten
T
Exiqon A/S, Bygstubben 9, 2945 Vedbaek, Denmark. tbr@exiqon.com
Lomholt
Christian
C
D001483:Base Sequence; D002784:Cholesterol / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*
D009841:Oligonucleotides; C527207:amino-LNA; D004247:DNA; D002784:Cholesterol