title: Effect of LDL cholesterol and treatment with losartan on end-stage renal disease in the RENAAL study.
abstract: Renal pathology and dyslipidemia commonly coexist. Treatments that lower albuminuria/proteinuria may lower lipids, but it is not known whether lipid lowering independent of lessening albuminuria/proteinuria slows progression of kidney disease. We examined the association between LDL cholesterol levels and treatment with losartan on end-stage renal disease (ESRD). Lipid levels and albuminuria measurements were obtained at baseline and at year 1 in a post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) study, which compared the effects of losartan- versus placebo-based antihypertensive therapy in patients with type 2 diabetes and nephropathy. LDL cholesterol lowering was associated with a lower risk of ESRD; however, this seemed to be largely an association with the reduction in albuminuria.
authors: Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, Pennsylvania, USA. andrew_tershakovec@merck.com
authors: Andrew M
authors: AM
authors: Tershakovec
authors: William F
authors: WF
authors: Keane
authors: Zhongxin
authors: Z
authors: Zhang
authors: Paulette A
authors: PA
authors: Lyle
authors: Gerald B
authors: GB
authors: Appel
authors: Janet B
authors: JB
authors: McGill
authors: Hans-Henrik
authors: HH
authors: Parving
authors: Mark E
authors: ME
authors: Cooper
authors: Shahnaz
authors: S
authors: Shahinfar
authors: Barry M
authors: BM
authors: Brenner
mesh_terms: D000419:Albuminuria / Q000378:metabolism; D008078:Cholesterol, LDL / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000378:metabolism; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
chemical_list: D008078:Cholesterol, LDL; D019808:Losartan