Synthesis and anti-HCV activity Of 2''-beta-hydroxymethylated nucleosides.
Synthesis of 2' -beta-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2' -beta-hydroxymethyl group has the appropriate electronic properties interfering with HCV polymerase.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Yoo
Byul Nae
BN
Kim
Hea Ok
HO
Lee
Kang Man
KM
Moon
Hyung Ryong
HR
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000737:chemistry
D000998:Antiviral Agents; D009705:Nucleosides; D011687:Purines; C079308:6-chloropurine