title: Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion.
abstract: The bolus intravenous injection of a novel medium-chain triglyceride:fish oil (FO) emulsion was recently proposed as a tool to provoke a rapid enrichment of cell phospholipids in long-chain polyunsaturated omega-3 fatty acids. In the present study, the enrichment of liver phospholipids and triglycerides in C20:5omega-3, C22:5omega-3 and C22:6omega-3 was assessed 60min after the intravenous administration of FO (1.0ml) to second-generation omega-3-depleted rats. When compared to uninjected rats, or animals injected with a control omega-3 fatty acid-poor medium-chain triglyceride:olive oil (OO) emulsion, the enrichment of liver phospholipids, and to a lesser extent liver triglycerides, attributable to the injection of the FO emulsion was more pronounced for C22:6omega-3 than C20:5omega-3, despite the presence of equal amounts of these two omega-3 fatty acids in the injected diglycerides and triglycerides. The possible determinants and potential beneficial effects of such a difference are briefly discussed.
authors: Laboratory of Experimental Surgery, Brussels Free University, 808 Route de Lennik, Brussels, Belgium.
authors: Sébastien
authors: S
authors: Peltier
authors: Laurence
authors: L
authors: Portois
authors: Willy J
authors: WJ
authors: Malaisse
authors: Yvon A
authors: YA
authors: Carpentier
mesh_terms: D000818:Animals; D004075:Diglycerides / Q000097:blood / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000097:blood / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000097:blood / Q000378:metabolism*; D005395:Fish Oils / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism*; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D004075:Diglycerides; D005395:Fish Oils; D010743:Phospholipids; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid