High rate of extensively drug-resistant tuberculosis in Indian AIDS patients.
Fifty-four full-blown AIDS patients suspected of having HIV-tuberculosis co-infection were investigated for the prevalence of extensively drug-resistant (XDR) Mycobacterium tuberculosis. Out of the 54 patients, M. tuberculosis was isolated from 24 (44.4%). Twelve (50%) isolates of these had resistance to first-line drugs, whereas four (33.33%) were also resistant to second-line drugs. All four patients, in whom XDR M. tuberculosis was isolated, died within 2.6 months of diagnosis.
Singh
Sarman
S
Division of Clinical Microbiology, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India.
Sankar
Manimuthu Mani
MM
Gopinath
Krishnamoorthy
K
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D054908:Extensively Drug-Resistant Tuberculosis / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D018655:Lymphocyte Count; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D015995:Prevalence; D013183:Sputum / Q000382:microbiology