title: Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.
abstract: Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.
authors: College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
authors: Lak Shin
authors: LS
authors: Jeong
authors: Jeong A
authors: JA
authors: Lee
authors: Hyung Ryong
authors: HR
authors: Moon
authors: Hea Ok
authors: HO
authors: Kim
authors: Kang Man
authors: KM
authors: Lee
authors: Hyun Joo
authors: HJ
authors: Lee
authors: Moon Woo
authors: MW
authors: Chun
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides; D015075:2-Aminopurine; C040510:2-amino-6-chloropurine