title: Efficient synthesis of thymidine boranophosphoramidates conjugated with amino acids.
abstract: An efficient synthesis of a thymidine boranophosphoramidate prodrug was accomplished using a phosphoramidite approach in high yield. This new class of compounds is designed to have improved antiviral and anticancer advantages conferred by combining the boranophosphate and normal nucleoside amino acid phosphoramidate. Compounds were characterized by MS and 31P NMR.
authors: Department of Chemistry, Duke University, Durham, North Carolina 27708, USA. brshaw@chem.duke.edu
authors: Shoeb I
authors: SI
authors: Khan
authors: Barbara Ramsay
authors: BR
authors: Shaw
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000596:Amino Acids; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D013936:Thymidine