title: Stereoselective synthesis of homo-apioneplanocin A as potential inhibitor of S-adenosylhomocysteine hydrolase.
abstract: Homo-apioneplanocin A (1) as a potential inhibitor of S-adenosylhomocysteine hydrolase was synthesized from D-ribose, employing stereoselective hydroxymethylation, regioselective oxidation, and regio- and chemoselective hydroboration as key steps.
authors: College of Pharmacy, Seoul National University, Seoul, Korea. mwchun@snu.ac.kr
authors: Moon Woo
authors: MW
authors: Chun
authors: Hyuk Woo
authors: HW
authors: Lee
authors: Jin-Hee
authors: JH
authors: Kim
authors: Hea Ok
authors: HO
authors: Kim
authors: Kang Man
authors: KM
authors: Lee
authors: Shantanu
authors: S
authors: Pal
authors: Hyung Ryong
authors: HR
authors: Moon
authors: Lak Shin
authors: LS
authors: Jeong
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D009705:Nucleosides; C526391:homo-apioneplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine