Investigation of microalbuminuria in nondiabetic, normotensive obese women.
OBJECTIVE
To investigate if obesity which is not accompanied by diabetes and/or hypertension is associated with microalbuminuria in female patients.


METHODS
A total of 77 obese female patients from the Outpatient Clinic of Endocrinology of Istanbul University Cerrahpasa Medical Faculty and 30 age-matched, lean, healthy women were enrolled in the study. Patients with accompanying diabetes mellitus, hypertension, obesity associated with any endocrine abnormality, hepatic or renal disease, fever, infectious disease, malignancy were excluded. Weight, height, body-mass index (BMI), waist circumference, waist/hip ratio (WHR) and systolic and diastolic blood pressures were recorded. Albumin excretion in 24-hour urine samples (UAE) were measured using SYNCHRON LX System with MA Microalbumin kit in two separate 24-hour urine samples from every patient. Statistical analysis was performed using t-test and Pearson's correlation in SPSS 12.0 for Windows Program.


RESULTS
The median albumin excretion in 24-hour urine sample was similar in obese and control groups (12.01 +/- 10.69 mg/day vs 9.35 +/- 4.09 mg/day; p= 0.211). There were no correlations between the albumin excretion in 24 hour urine samples and BMI, waist circumference, WHR, systolic or diastolic blood pressure.


CONCLUSIONS
Diabetes mellitus and hypertension are known to be associated with microalbuminuria. In our study, microalbuminuria was not detected in obese women without diabetes and/or hypertension and UAE was similar in obese and lean women.
Yesim
Tijen Erdem
TE
Division of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul.
Ugurlu
Serdal
S
Caglar
Erkan
E
Balci
Huriye
H
Ucgul
Ayca
A
Sarkis
Cihat
C
Acbay
Ozer
O
Gundogdu
Sadi
S
D000328:Adult; D000419:Albuminuria / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000503:physiopathology / Q000652:urine; D015995:Prevalence; D012307:Risk Factors; D014421:Turkey; D049629:Waist-Hip Ratio