title: Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
abstract: A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors: Chen
authors: C
authors: Zhao
authors: Jordan
authors: J
authors: Blum
authors: Alan
authors: A
authors: Chen
authors: Hyog Young
authors: HY
authors: Kwon
authors: Seung Hye
authors: SH
authors: Jung
authors: J Michael
authors: JM
authors: Cook
authors: Anand
authors: A
authors: Lagoo
authors: Tannishtha
authors: T
authors: Reya
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D017353:Gene Deletion; D017930:Genes, Reporter; D006413:Hematopoietic System / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D017254:Leukemic Infiltration; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D051379:Mice; D014411:Neoplastic Stem Cells / Q000473:pathology*; D010766:Phosphorylation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D050799:STAT5 Transcription Factor / Q000378:metabolism; D033581:Stem Cell Transplantation; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000172:deficiency*
chemical_list: D050799:STAT5 Transcription Factor; D051153:Wnt Proteins; D051176:beta Catenin; D016044:Fusion Proteins, bcr-abl