Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature.
BACKGROUND
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.


METHODS
Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.


RESULTS
The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.


CONCLUSIONS
This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
Gonzalez-Cuyar
Luis F
LF
Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, USA. luisgonzcuyar@gmail.com
Tavora
Fabio
F
Burke
Allen P
AP
Gocke
Christopher D
CD
Zimrin
Ann
A
Sauk
John J
JJ
Zhao
Xiafeng F
XF