title: Cobalt-catalyzed reductive Mannich reactions of 4-acryloylmorpholine with N-tosyl aldimines.
abstract: Using cobalt catalysis, diethylzinc promotes the conjugate reduction of 4-acryloylmorpholine to produce the corresponding ethylzinc enolate, which reacts with N-tosyl aldimines to afford beta-aminoamides.
authors: School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK.
authors: Oscar
authors: O
authors: Prieto
authors: Hon Wai
authors: HW
authors: Lam
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008352:Mannich Bases / Q000737:chemistry*; D009025:Morpholines / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: C527295:4-acryloylmorpholine; D000178:Acrylamides; D007097:Imines; D008352:Mannich Bases; D009025:Morpholines; D003035:Cobalt