title: Sulfur containing acyclovir derivatives: synthesis, cytotoxic activity, and cell phenotype studies.
abstract: New 2-amino-6-oxo-8-thioxo-9-substituted purine derivatives were prepared and assayed for the in vitro cytotoxic activity. Some products exhibited moderate activity on HT-1080 cells and rather high activity on MG-22A cells.
authors: Latvian Institute of Organic Synthesis, Riga, Latvia. ikaunieks@osi.lv
authors: Martins
authors: M
authors: Ikaunieks
authors: Irina
authors: I
authors: Shestakova
authors: Ilona
authors: I
authors: Domracheva
authors: Sergey
authors: S
authors: Belyakov
authors: Marina
authors: M
authors: Madre
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013457:Sulfur Compounds; D000212:Acyclovir