Molecular modes of action of cytotoxic alkaloids: from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance.
Wink
Michael
M
Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany. wink@uni-hd.de
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D018432:Drug Resistance, Multiple; D006801:Humans; D008941:Spindle Apparatus / Q000187:drug effects*; D059003:Topoisomerase Inhibitors
D000470:Alkaloids; D059003:Topoisomerase Inhibitors; D004247:DNA