title: Development of an antitumor adenosine analog, 3''-ethynyladenosine.
abstract: 3'-ethynyladenosine (EAdo) was an adenosine analog with potent antitumor activity against various human tumor cells in vitro. However, EAdo was enzymatically inactivated by adenosine deaminase (ADA) in vitro and in vivo. Therefore, we synthesized two ADA-resistant EAdo derivatives (2-F-EAdo and EAdo-5'-monophosphate, EAMP) and examined their antitumor activities.
authors: Cancer Research Institute, Kanazawa University, Kanazawa, Japan. yendo@kenroku.kanazawa-u.ac.jp
authors: Yoshio
authors: Y
authors: Endo
authors: Tohru
authors: T
authors: Obata
authors: Makoto
authors: M
authors: Nomura
authors: Masakazu
authors: M
authors: Fukushima
authors: Yuji
authors: Y
authors: Yamada
authors: Akira
authors: A
authors: Matsuda
authors: Takuma
authors: T
authors: Sasaki
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000243:Adenosine Deaminase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003641:Deamination / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans
chemical_list: C526390:3'-ethynyladenosine; D000970:Antineoplastic Agents; D000243:Adenosine Deaminase; D000241:Adenosine