The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level.
The LNA dinucleotide mimic of TpT whose two-sugar puckers are locked in the C3'-endo conformation selectively produces the corresponding cyclobutane pyrimidine dimer under 254 nm irradiation. In the natural series (TpT) the sugar puckers are in a major C2'-endo sugar conformation and the (6-4) photoproduct is also produced. Consequently, this study demonstrates that the C2'-endo conformation of the sugar pucker is necessary for (6-4) photoproduct formation.
Desnous
Céline
C
Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91190 Gif sur Yvette, France, Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
Babu
B Ravindra
BR
Moriou
Céline
C
Mayo
Javier Ulises Ortiz
JU
Favre
Alain
A
Wengel
Jesper
J
Clivio
Pascale
P
D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D010777:Photochemistry; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry
D002241:Carbohydrates; D015226:Dinucleoside Phosphates; D013936:Thymidine