Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase.
A new approach was developed for the synthesis of 4'-modified neplanocin A analogues, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinylstannane 13, a key intermediate in the present approach, was prepared by radical-mediated sulfur-extrusive stannylation.
Kumamoto
Hiroki
H
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. kumamoto@pharm.showa-u.ac.jp
Deguchi
Kazuki
K
Takahashi
Nonoko
N
Tanaka
Hiromichi
H
Kitade
Yukio
Y
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013455:Sulfur / Q000737:chemistry
D004791:Enzyme Inhibitors; D013455:Sulfur; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine