title: An automatic procedure for the analysis of electric and magnetic mismatch negativity based on anatomical brain mapping.
abstract: Data processing techniques in electroencephalography (EEG) and magnetoencephalography (MEG) need user interactions. However, particularly in clinical applications, fast and objective data processing is important. Here we present an observer-independent method for EEG and MEG analysis of mismatch negativity (MMN) that allows reliable estimation of source activity based on objective anatomical references. The procedure integrates several steps including artifact rejection, source estimation and statistical analysis. It enables the evaluation of source activity in a fully automatic and unsupervised manner. To test its feasibility we obtained EEG and MEG responses in an auditory oddball paradigm in 12 healthy volunteers. The automatized method of EEG and MEG data analysis estimated source activity. The automatically detected MMN was closely comparable with the results obtained by a user-controlled method based on the dipole fitting. The presented workflow can be performed easily, rapidly, and reliably. This development may open new fields in research and clinical applications of source-based EEG and MEG.
authors: Department of Psychiatry and Psychotherapy, University Hospital Aachen, RWTH Aachen, 52074 Aachen, Germany. MZvyagintsev@UKAachen.de
authors: Mikhail
authors: M
authors: Zvyagintsev
authors: Heike
authors: H
authors: Thönnessen
authors: Jürgen
authors: J
authors: Dammers
authors: Frank
authors: F
authors: Boers
authors: Klaus
authors: K
authors: Mathiak
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods* / Q000706:statistics & numerical data; D001330:Electronic Data Processing; D004594:Electrophysiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D015225:Magnetoencephalography / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D013216:Reflex, Startle / Q000502:physiology*