title: Intramolecular direct arylation in an A,C-functionalized calix[4]arene.
abstract: A recently developed efficient method for intramolecular direct arylation is employed on a doubly functionalized calix[4]arene fixed in the cone conformation. The reaction takes place in high yield leading to meta substituted calix[4]arenes. The functionalities are located at two opposite aromatic rings and the two possible diastereomers are obtained in a 1:1 ratio. Full sets of data including crystal structures for both isomers are presented. The NMR data reveal that even at temperatures up to 120 degrees C both isomers are fixed in a flattened cone conformation with the substituted aromatic units pointing outwards.
authors: Organische Chemie I, Universität Bielefeld, Universitätsstr. 25, 33501 Bielefeld, Germany. oc1jm@uni-bielefeld.de
authors: Olaf G
authors: OG
authors: Barton
authors: B
authors: B
authors: Neumann
authors: H-G
authors: HG
authors: Stammler
authors: Jochen
authors: J
authors: Mattay