title: Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes.
abstract: OBJECTIVE
  To determine whether self-perceived memory impairment is associated with the severity of white matter changes (WMC) and is related to cognitive impairment.
  
  
  METHODS
  Data were drawn from the multinational Leukoaraiosis and Disability Study (LADIS), which investigates the impact of WMC on global functioning. WMC severity was rated using the Fazekas scale. Medial temporal lobe atrophy (MTA) was scored visually and mean values were calculated. The neuropsychological battery consisted of the Mini-Mental State Examination, a modified version of the VADAS-Cog, Trail making and Stroop tests. A question about self-perceived memory impairment was used as a measure for presence of memory complaints. Cognitive performance was analysed test-by-test and in three main domains: memory, executive functions and speed/motor control. The Geriatric Depression Scale (GDS) was used as a measure of depressive symptoms.
  
  
  RESULTS
  Six hundred and thirty-eight subjects were included in this study. No association was found between memory complaints and the severity of WMC. Subjects with memory complaints (n = 399) had a higher GDS score [t((637)) = -7.15; p<0.02] and performed worse on almost all cognitive tests and on the three cognitive domains. Multiple linear regression showed that the worse performance on the memory domain was associated with memory complaints independently of depressive symptoms, WMC severity and MTA (R(2) = 0.183; F = 17.09, beta = -0.126; p<0.05).
  
  
  CONCLUSIONS
  In a sample of non-disabled elderly subjects with WMC, self-perceived memory impairment is significantly associated with objective memory impairment independently of the WMC severity, depressive symptoms and MTA.
authors: Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal. bruno.a.miranda@gmail.com
authors: B
authors: B
authors: Miranda
authors: S
authors: S
authors: Madureira
authors: A
authors: A
authors: Verdelho
authors: J
authors: J
authors: Ferro
authors: L
authors: L
authors: Pantoni
authors: E
authors: E
authors: Salvadori
authors: H
authors: H
authors: Chabriat
authors: T
authors: T
authors: Erkinjuntti
authors: F
authors: F
authors: Fazekas
authors: M
authors: M
authors: Hennerici
authors: J
authors: J
authors: O'Brien
authors: P
authors: P
authors: Scheltens
authors: M C
authors: MC
authors: Visser
authors: L-O
authors: LO
authors: Wahlund
authors: G
authors: G
authors: Waldemar
authors: A
authors: A
authors: Wallin
authors: D
authors: D
authors: Inzitarion
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000175:diagnosis* / Q000523:psychology; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D005060:Europe; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000175:diagnosis* / Q000523:psychology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics; D012649:Self Concept; D013702:Temporal Lobe / Q000473:pathology