Enantioseparation of 2-aryl-1,3-dicarbonyl analogues by high performance liquid chromatography using polysaccharide type chiral stationary phase.
The HPLC chiral separation of 21 kinds of 2-aryl-1,3-dicarbonyl analogues was investigated in normal phase mode with amylose tris(3,5-dimethylphenylcarbamate), amylose tris((S)-1-phenylethylcarbamate), cellulose tris(3,5-dimethylphenylcarbamate), and cellulose tris(4-methylbenzoate) chiral stationary phases, respectively. The whole set of 2-aryl-1,3-dicarbonyl analogues shows better enantioselectivity and enantioseparation on amylose tris(3,5-dimethylphenyl carbamate) (Chiralpak AD-H). The temperature dependence of enantioselectivity was studied to improve the enantioseparation. In addition, efforts are made to relate analyte structure with the quality of the achieved chiral separation.
Xu
Zhe
Z
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Ding
Zuoding
Z
Xu
Xu
X
Xie
Xiaoan
X
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D009930:Organic Chemicals / Q000737:chemistry* / Q000302:isolation & purification*; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D009930:Organic Chemicals; D011134:Polysaccharides