Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
van Es
Michael A
MA
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
van Vught
Paul W J
PW
Blauw
Hylke M
HM
Franke
Lude
L
Saris
Christiaan G J
CG
Van den Bosch
Ludo
L
de Jong
Sonja W
SW
de Jong
Vianney
V
Baas
Frank
F
van't Slot
Ruben
R
Lemmens
Robin
R
Schelhaas
Helenius J
HJ
Birve
Anna
A
Sleegers
Kristel
K
Van Broeckhoven
Christine
C
Schymick
Jennifer C
JC
Traynor
Bryan J
BJ
Wokke
John H J
JH
Wijmenga
Cisca
C
Robberecht
Wim
W
Andersen
Peter M
PM
Veldink
Jan H
JH
Ophoff
Roel A
RA
van den Berg
Leonard H
LH
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D016022:Case-Control Studies; D002897:Chromosomes, Human, Pair 7; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010447:Peptide Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015221:Potassium Channels / Q000235:genetics*; D044465:White People / Q000235:genetics
D009419:Nerve Tissue Proteins; D015221:Potassium Channels; C503535:DPP6 protein, human; D010447:Peptide Hydrolases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases