[Pharmacological sympatectomy changes heart's inotropic reaction on serotonin in postnatal ontogenesis of rats].
In the present study, the influence of 0.1 microM, 1.0 microM, 10.0 microM serotonin (5-HT) on inotropic function (contraction force, time to peak force, time to relaxation) of desympathetized rats by guanethidine in postnatal ontogenesis was investigated. 5-HT has a positive inotropic effect on atria (178 %) and ventricles (122%) in 21-day old rats. In 21-day old desympathetized rats, serotonin influence on the atrium was depressed by 49 %, while ventricle contraction did not change. Atria contraction force in 100-day old rats increased by 38 %, while ventricle contraction force was decreased by 5-HT. In the 100-day old desympathetized rats, a significant elevation ofinotropic effect of 5-HT in atria by 91% and ventricles by 51% was revealed. It was shown that injection of guanethidine during three weeks since birth changes reaction on 5-HT in postnatal ontogenesis ofrats. In 21-day old desympathetized rats, 5-HT had a negative inotropic effect in the early period after pharmacological sympatectomy, while in the period of compensation the elevation of the positive inotropic effect of 5-HT occurred. Positive inotropic effect of atria in 100-day old desympathetized rats was twice as high as in control group. Our data suggest that there exists an interaction between adrenergic and 5-HT regulation in postnatal ontogenesis of rats.
Kirillova
V V
VV
Nigmatullina
R R
RR
D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D006145:Guanethidine / Q000494:pharmacology*; D006325:Heart Atria / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D018490:Serotonin Agents / Q000378:metabolism / Q000494:pharmacology*; D013563:Sympathectomy, Chemical
D018663:Adrenergic Agents; D018490:Serotonin Agents; D012701:Serotonin; D006145:Guanethidine