title: Muscular mitochondrial dysfunction and type 2 diabetes mellitus.
abstract: OBJECTIVE
  Muscular mitochondrial dysfunction, leading to the accumulation of fat in skeletal muscle, has been proposed to be involved in the development of type 2 diabetes mellitus. Here, we review human studies that investigated various aspects of mitochondrial function in relation to muscular insulin sensitivity and/or diabetes.
  
  
  RESULTS
  In-vivo magnetic resonance spectroscopy allows assessment of mitochondrial functionality from adenosine triphosphate flux in the nonexercising state and from phosphocreatine recovery from (sub)maximal exercising. Application of both approaches revealed reduced mitochondrial oxidative capacity in insulin-resistant (pre)diabetic humans. Reductions in mitochondrial density may contribute to, or even underlie, these findings as well as intrinsic defects in mitochondrial respiration. So far, only two studies reported measurements of mitochondrial respiratory capacity in intact mitochondria in diabetic patients, with inconsistent findings.
  
  
  CONCLUSIONS
  Muscular mitochondrial aberrations in type 2 diabetes mellitus can be detected, but it is so far unclear if these aberrations are causally related to the development of the disease. Alternatively, mitochondrial dysfunction may simply be the consequence of elevated plasma fatty acids or glucose levels.
authors: Department of Human Biology, Maastricht University, Maastricht, The Netherlands.
authors: Vera B
authors: VB
authors: Schrauwen-Hinderling
authors: Michael
authors: M
authors: Roden
authors: M Eline
authors: ME
authors: Kooi
authors: Matthijs Kc
authors: MK
authors: Hesselink
authors: Patrick
authors: P
authors: Schrauwen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D019069:Cell Respiration; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D009682:Magnetic Resonance Spectroscopy; D008931:Mitochondria, Muscle / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010085:Oxidative Phosphorylation
chemical_list: D000255:Adenosine Triphosphate