Synthesis and incorporation of a simple acyclic furan containing phosphoramidite.
A novel furan containing phosphoramidite was synthesized and incorporated into model oligonucleotides. This glycol nucleic acid based building block contains a furan unit substituting the natural base, and can be used for post synthetic oligonucleotide modifications by orthogonal chemistries such as Schiff base formation after in situ oxidation or Diels-Alder cycloadditions.
Stevens
K
K
Laboratory for Organic and Biomimetic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281(S4), B-9000 Ghent, Belgium.
Madder
A
A
D001483:Base Sequence; D005663:Furans / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D005663:Furans; D009705:Nucleosides; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; C039281:furan