title: CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry.
abstract: The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure. The program is freely available at http://www.pu.kielce.pl/ibiol/cabas.
authors: Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warszawa, Poland.
authors: Joanna
authors: J
authors: Deperas
authors: Marta
authors: M
authors: Szluinska
authors: Marta
authors: M
authors: Deperas-Kaminska
authors: Alan
authors: A
authors: Edwards
authors: David
authors: D
authors: Lloyd
authors: Carita
authors: C
authors: Lindholm
authors: Horst
authors: H
authors: Romm
authors: Laurence
authors: L
authors: Roy
authors: Raymond
authors: R
authors: Moss
authors: Josselin
authors: J
authors: Morand
authors: Andrzej
authors: A
authors: Wojcik
mesh_terms: D000465:Algorithms; D001681:Biological Assay / Q000295:instrumentation / Q000379:methods / Q000592:standards; D002869:Chromosome Aberrations / Q000187:drug effects*; D020732:Cytogenetic Analysis / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D005060:Europe; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software