Bone morphogenetic proteins: a realistic alternative to bone grafting for alveolar reconstruction.
Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.
Wikesjö
Ulf M E
UM
Laboratory for Applied Periodontal & Craniofacial Regeneration, Medical College of Georgia School of Dentistry, 1120 15th Street, Augusta, GA 30912, USA. uwikesjo@mail.mcg.edu
Huang
Yi-Hao
YH
Polimeni
Giuseppe
G
Qahash
Mohammed
M
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000543:Alveoloplasty; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous; D016503:Drug Delivery Systems; D006801:Humans; D019647:Oral Surgical Procedures; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000627:therapeutic use
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2