Asymmetric synthesis of C2-symmetric vicinal diamines via reductive dimerization of N-acylpyridinium and related salts.
A new route to C2-symmetric diamines via an asymmetric reductive dimerization of 1-acylpyridinium salts and their benzo derivatives is described. This method is practical as the starting heterocycles and chiral auxiliaries are readily available. The titanium reducing agent is inexpensive and easy to prepare. Several novel enantiopure C2-symmetric diamine derivatives were synthesized using this method.
Bharathi
Pandi
P
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.
Comins
Daniel L
DL
D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D015394:Molecular Structure; D011726:Pyridinium Compounds / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
D003959:Diamines; D011726:Pyridinium Compounds; D012492:Salts