Development of an antitumor adenosine analog, 3''-ethynyladenosine.
3'-ethynyladenosine (EAdo) was an adenosine analog with potent antitumor activity against various human tumor cells in vitro. However, EAdo was enzymatically inactivated by adenosine deaminase (ADA) in vitro and in vivo. Therefore, we synthesized two ADA-resistant EAdo derivatives (2-F-EAdo and EAdo-5'-monophosphate, EAMP) and examined their antitumor activities.
Endo
Yoshio
Y
Cancer Research Institute, Kanazawa University, Kanazawa, Japan. yendo@kenroku.kanazawa-u.ac.jp
Obata
Tohru
T
Nomura
Makoto
M
Fukushima
Masakazu
M
Yamada
Yuji
Y
Matsuda
Akira
A
Sasaki
Takuma
T
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000243:Adenosine Deaminase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003641:Deamination / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans
C526390:3'-ethynyladenosine; D000970:Antineoplastic Agents; D000243:Adenosine Deaminase; D000241:Adenosine