[Resistance to azolic compounds in clinical Trichophyton spp. strains].
The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.
Méndez-Tovar
Luis Javier
LJ
Laboratorio de Investigación Médica en Dermatología y Micología "Dr. Ernesto Macotela", Hospital de Especialidades "Dr. Bernardo Sepúlveda", UMAE Centro Médico Nacional Siglo XXI, IMSS, México D.F., México. ljmt@servidor.unam.mx
Manzano-Gayosso
Patricia
P
Velásquez-Hernández
Verónica
V
Millan-Chiu
Blanca
B
Hernández-Hernández
Francisca
F
Mondragón-González
Rafael
R
López-Martínez
Rubén
R
D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D025141:Drug Resistance, Fungal; D026141:Drug Resistance, Multiple, Fungal; D004821:Epidermophyton / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008800:Mexico; D008864:Microsporum / Q000187:drug effects / Q000302:isolation & purification; D014009:Onychomycosis / Q000382:microbiology; D014005:Tinea / Q000382:microbiology*; D014006:Tinea Capitis / Q000382:microbiology; D014008:Tinea Pedis / Q000382:microbiology; D014249:Trichophyton / Q000187:drug effects* / Q000302:isolation & purification
D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole; D007654:Ketoconazole