HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART.
As immune recovery during HAART is mainly caused by the expansion of X4-naive cells, we studied the evolution of HIV tropism in the reservoir of 34 patients receiving 48 weeks of HAART. No change in virus tropism was observed over time, but patients with X4 viruses had higher HIV-1 proviral DNA levels than patients with R5 viruses. This suggests that CCR5 antagonist activity should not be compromised in patients harbouring R5 viruses before starting HAART.
Soulié
Cathia
C
Department of Virology-EA2387, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France.
Marcelin
Anne-Geneviève
AG
Ghosn
Jade
J
Amellal
Bahia
B
Assoumou
Lambert
L
Lambert
Sidonie
S
Duvivier
Claudine
C
Costagliola
Dominique
D
Katlama
Christine
C
Calvez
Vincent
V
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D004279:DNA, Viral / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011533:Proviruses; D019713:Receptors, CCR5 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*; D013997:Time Factors; D018523:Tropism; D019562:Viral Load
D019380:Anti-HIV Agents; D004279:DNA, Viral; D019713:Receptors, CCR5; D019718:Receptors, CXCR4