MicroRNA-155 function in B Cells.
Vigorito et al. (2007) report (in this issue of Immunity) that B cells require microRNA (miR)-155 for normal production of isotype-switched, high-affinity antibodies and for a memory response. They identify transcriptional regulator Pu.1 as a functionally important target of miR-155 in B cells.
Calame
Kathryn
K
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. klc1@columbia.edu
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D017578:Immunoglobulin Class Switching; D007156:Immunologic Memory; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D000099232:Proto-Oncogene Protein Spi-1
D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; D011947:Receptors, Antigen, B-Cell; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1