title: The serial changes of ghrelin and leptin levels and their relations to weight loss after laparoscopic minigastric bypass surgery.
abstract: BACKGROUND
  The ghrelin and leptin levels have been reported to be correlated with weight loss after bariatric surgery. However, the serial changes of ghrelin and leptin levels after laparoscopic minigastric bypass surgery (LMGBP) have not been reported yet. Therefore, we aimed to evaluate their serial changes and to analyze their relations to weight reduction after LMGBP.
  
  
  METHODS
  Serial fasting serum leptin and ghrelin concentrations were measured in 68 morbidly obese patients before (M0) and 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months after LMGBP surgery. The correlations between ghrelin, insulin, and leptin concentrations and weight reduction were analyzed.
  
  
  RESULTS
  Leptin levels were significantly reduced at 1, 3, 6, and 12 months after surgery, respectively (vs M0, p < 0.001), whereas the ghrelin concentrations were not significantly changed after surgery. The percent of excess BMI lost (%EBL) 12 months after surgery was negatively correlated with higher preoperative ghrelin concentrations (p = 0.004) and larger preoperative BMI (p = 0.002) in the multivariate analysis.
  
  
  CONCLUSIONS
  Higher preoperative ghrelin concentrations and larger BMI are predictive of less %EBL at 12 months after LMGBP surgery.
authors: Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei, Taiwan.
authors: Jyh-Ming
authors: JM
authors: Liou
authors: Jaw-Town
authors: JT
authors: Lin
authors: Wei-Jei
authors: WJ
authors: Lee
authors: Hsiu-Po
authors: HP
authors: Wang
authors: Yi-Chia
authors: YC
authors: Lee
authors: Han-Mo
authors: HM
authors: Chiu
authors: Ming-Shiang
authors: MS
authors: Wu
mesh_terms: D000328:Adult; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D010535:Laparoscopy; D020738:Leptin / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D011237:Predictive Value of Tests; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: D054439:Ghrelin; D007328:Insulin; D020738:Leptin