title: [Expression of prostate cancer antigen-1 in prostate cancer and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of prostate cancer antigen-1 (PCA-1) in different prostate tissues and analyze its correlation with the clinical parameters of prostate cancer (PCa).
  
  
  METHODS
  The expression of PCA-1 mRNA was detected by RT-PCR in the samples from 45 cases of PCa with various clinico-pathologic characteristics, 30 cases of high-grade prostatic intraepithelial neoplasia (HG-PIN), 43 cases of BPH and 39 cases of other carcinoma tissues. The correlation of PCA-1 mRNA expression with the clinical parameters of PCa was statistically analyzed and the PCA-1 expression was examined in different samples by immunohistochemistry.
  
  
  RESULTS
  The positive expression rate of PCA-1 mRNA was 88.9% and 60.0% and that of PCA-1 protein was 84.4% and 50.0% in the patients with PCa and HG-PIN, respectively. PCA-1 mRNA and PCA-1 proteins were not expressed in the BPH and other carcinoma tissues. The expression of PCA-1 mRNA was unrelated with the clinical parameters of PCa (P > 0.05).
  
  
  CONCLUSIONS
  It is suggested that PCA-1 is a PCa-specific gene and its expression is unrelated to the clinical parameters of PCa. It might serve as a specific biomarker for the early diagnosis of PCa.
authors: Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. liubq76@yahoo.com.cn
authors: Bing-qian
authors: BQ
authors: Liu
authors: Yu-dong
authors: YD
authors: Wu
authors: Jin-xing
authors: JX
authors: Wei
authors: Tong
authors: T
authors: Zhang
authors: Ran-lu
authors: RL
authors: Liu
authors: Teng-xiang
authors: TX
authors: Ma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000096:biosynthesis / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger; D017430:Prostate-Specific Antigen