title: Genetic and metabolic aspects of androstenone and skatole deposition in pig adipose tissue: a review.
abstract: High levels of androstenone and skatole in fat tissues are considered the primary causes of boar taint, an unpleasant odour and flavour of the meat from non-castrated male pigs. The aim of this article is to review our current knowledge of the biology and genetic control of the accumulation of androstenone and skatole in fat tissue. Two QTL mapping studies have shown the complexity of the genetic control of these traits. During the last ten years, several authors have taken a more physiological approach to investigate the involvement of genes controlling the metabolism of androstenone and skatole. Although some authors have claimed the identification of candidate genes, it is more appropriate to talk about target genes. This suggests that genes affecting androstenone and skatole levels will have to be sought for among specific or non-specific transcription factors interacting with these target genes.
authors: INRA, UMR 444 de Génétique cellulaire, BP52627, 31326 Castanet-Tolosan, France. annie.robic@toulouse.inra.fr
authors: Annie
authors: A
authors: Robic
authors: Catherine
authors: C
authors: Larzul
authors: Michel
authors: M
authors: Bonneau
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000738:Androsterone / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000502:physiology; D008297:Male; D008954:Models, Biological; D040641:Quantitative Trait Loci; D012862:Skatole / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism; D013552:Swine / Q000235:genetics* / Q000378:metabolism*; D013737:Testis / Q000378:metabolism
chemical_list: D013431:Sulfates; D003577:Cytochrome P-450 Enzyme System; D012862:Skatole; D000738:Androsterone