title: Facile synthesis of a "ready to use" precursor of porphobilinogen and its amino Acid derivatives.
abstract: A practical synthesis of porphobilinogen based on the biosynthetic mechanism is described. The crossed Mukayiama aldol reaction is the key step creating the central carbon-carbon bond between the two protected forms of 5-aminolevulinic acids. The optimized sequence gives a crystalline, storable precursor, which can be transformed in high yield into porphobilinogen and bioconjugates thereof. The enzymatic hydrolysis of the precursor produces porphobilinogen in quantitative yield.
authors: Institut de Chimie, Université de Neuchatel, Rue Emile-Argand 11, PO 158, CH-2009 Neuchatel, Switzerland.
authors: Carole Pissot
authors: CP
authors: Soldermann
authors: Ramakrishnan
authors: R
authors: Vallinayagam
authors: Manuel
authors: M
authors: Tzouros
authors: Reinhard
authors: R
authors: Neier
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011162:Porphobilinogen / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D011162:Porphobilinogen