Some novel aminopropyl nucleoside phosphonates.
The aminopropyl nucleoside phosphonates 1-3 have an amino function within either the acyclic chain (series 2 and 3) or as substituent (series 1) of HPMPC (Cidofovir). Both purine and pyrimidine nucleoside anologs have been synthesized. In contrast to HPMPC, only a weak antiherpes virus activity could be demonstrated for 2b and 2c.
Zhou
Ding
D
Laboratory of Medicinal Chemistry, Rega Institute, Leuven, Belgium.
Lagoja
Irene M
IM
Van Aerschot
Arthur
A
D000998:Antiviral Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011437:Propylamines / Q000737:chemistry*
D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates; D011437:Propylamines; D003596:Cytosine; D000077404:Cidofovir