title: Performance monitoring local field potentials in the medial frontal cortex of primates: anterior cingulate cortex.
abstract: We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at approximately 70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.
authors: Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology,Vanderbilt University, Nashville, Tennessee, USA.
authors: Erik E
authors: EE
authors: Emeric
authors: Joshua W
authors: JW
authors: Brown
authors: Melanie
authors: M
authors: Leslie
authors: Pierre
authors: P
authors: Pouget
authors: Veit
authors: V
authors: Stuphorn
authors: Jeffrey D
authors: JD
authors: Schall
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003220:Conflict, Psychological; D004192:Discrimination, Psychological / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D005246:Feedback; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D007266:Inhibition, Psychological; D008255:Macaca radiata / Q000033:anatomy & histology* / Q000502:physiology; D008297:Male; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D014794:Visual Fields