title: CD30 supports lung inflammation.
abstract: The physiological functions of CD30 have not been fully elucidated. Here we show that in CD30-deficient mice (CD30(-/-)), lung inflammation is significantly diminished in the ovalbumin (OVA) model of airway hyperreactivity. In CD30(-/-) mice, the recruitment of eosinophils into the airways after OVA-aerosol challenge of OVA-primed mice was significantly diminished when compared with wild-type (w.t.) mice. IL-13 levels were also significantly reduced in CD30(-/-) mice while levels of IFN-gamma, IL-4, IL-5 and IgE in bronchoalveolar lavage fluid, lung tissue and serum were comparable to w.t. mice. Peribronchial lymph node cells from CD30(-/-) mice, re-stimulated in vitro with OVA, secreted significantly lower levels of IL-13 than those from w.t. mice, but showed normal proliferative response and other cytokine production. Exogenous IL-13 reconstituted airway recruitment of leukocytes in OVA-challenged CD3O(-/-) mice. Adoptive transfer to naive w.t. mice of in vitro OVA-re-stimulated spleen cells from CD30(-/-) mice failed to induce eosinophilic pulmonary inflammation in contrast to transfer of primed cells from w.t. mice. These results indicate that CD30 is a regulator of T(h)2 responses in the effector-memory phase and a regulator of IL-13 production in memory cells in the lung.
authors: Department of Biological Science, School of Science and Technology, Jeonju University, Jeonju 560-759, Korea.
authors: Sang-Yun
authors: SY
authors: Nam
authors: Young-Hyun
authors: YH
authors: Kim
authors: Jeong-Su
authors: JS
authors: Do
authors: Yun-Hwa
authors: YH
authors: Choi
authors: Hyo-Jung
authors: HJ
authors: Seo
authors: Ho-Keun
authors: HK
authors: Yi
authors: Pyung-Han
authors: PH
authors: Hwang
authors: Chang-Ho
authors: CH
authors: Song
authors: Hern-Ku
authors: HK
authors: Lee
authors: Jeong-Su
authors: JS
authors: Kim
authors: Eckhard R
authors: ER
authors: Podack
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004804:Eosinophils / Q000166:cytology / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D018793:Interleukin-13 / Q000096:biosynthesis* / Q000235:genetics; D017730:Ki-1 Antigen / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D011014:Pneumonia / Q000276:immunology* / Q000503:physiopathology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: D018793:Interleukin-13; D017730:Ki-1 Antigen; D010047:Ovalbumin