Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice.
OBJECTIVE
To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice.


METHODS
Oral treatment of lupeol (1 mg/animal) and MPE (1 mL [20% w/v]/animal) was given separately to animals along with subcutaneous injection of testosterone (5 mg/kg body weight) consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species (ROS) levels, lipid peroxidation and antioxidant enzymes status (catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase).


RESULTS
In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes.


CONCLUSIONS
The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer.
Prasad
Sahdeo
S
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M.G.Marg, Lucknow, India.
Kalra
Neetu
N
Singh
Madhulika
M
Shukla
Yogeshwer
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D031022:Mangifera; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000008:administration & dosage; D011467:Prostate / Q000187:drug effects* / Q000201:enzymology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013739:Testosterone / Q000008:administration & dosage*; D014315:Triterpenes / Q000008:administration & dosage*; D000094042:Lupanes
D000975:Antioxidants; D002374:Catalase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D013739:Testosterone; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes