title: Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate: a case report and review of literature.
abstract: Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare clinical entity, characterized by a chronic inflammation causing thickening of the dura. Adequate therapeutic management is still a matter of debate. We present a patient with an IHCP, non-responsive to corticotherapy. Oral methotrexate was introduced (12.5 mg weekly) and total remission was observed after 6 weeks, both clinically and after neuro-imaging. We conclude that methotrexate can be effective and a therapeutical option in patients with IHCP who are resistant to corticotherapy or present major side-effects of chronic corticosteroids use.
authors: Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands, T.Bosman@LUMC.nl
authors: T
authors: T
authors: Bosman
authors: C
authors: C
authors: Simonin
authors: D
authors: D
authors: Launay
authors: S
authors: S
authors: Caron
authors: A
authors: A
authors: Destée
authors: L
authors: L
authors: Defebvre
mesh_terms: D000284:Administration, Oral; D004388:Dura Mater / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D008727:Methotrexate