A simple nucleic acid alternative: aminopropyl nucleic acids (APNAs).
Aminopropyl nucleic acids are constitutionally simple nucleic acids alternatives with one chiral center per nucleotide and with the constitutional potential to hybridize with RNA. Both R and S isomers of the 3'-or 2'-aminopropyl nucleosides were incorporated either into DNA or likewise were used for fully modified sequences. The (R)-adenine analogue, yielding (S)-APNA, can be considered as a candidate for universal base pairing.
Zhou
Ding
D
Laboratory of Medicinal Chemistry, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Schepers
Guy
G
Van Aerschot
Arthur
A
D000577:Amides / Q000737:chemistry*; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry*; D011437:Propylamines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D000577:Amides; D009696:Nucleic Acids; D009705:Nucleosides; D010756:Phosphoric Acids; D011437:Propylamines; D012313:RNA; D004247:DNA; C011067:phosphoramidic acid