title: Uremic toxins: what are they? An integrated overview of pathobiology and classification.
abstract: Toxic substances, known as uremic toxins, accumulate in body fluids during the course of progressive, chronic kidney disease. This article will briefly summarize current views on the definition, physico-chemical characteristics, pathobiological mechanisms for generation and retention, and cellular pathophysiology of uremic toxins. In addition, this article will attempt to integrate these disparate phenomena into a systems biology approach as to how such toxins lead to the diverse clinical manifestations so characteristic of the uremic state.
authors: Department of Internal Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. glassock@cox.net
authors: Richard J
authors: RJ
authors: Glassock
mesh_terms: D000873:Anthracenes / Q000633:toxicity*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008970:Molecular Weight; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D014118:Toxins, Biological / Q000145:classification; D014511:Uremia / Q000139:chemically induced / Q000145:classification* / Q000473:pathology / Q000503:physiopathology*
chemical_list: D000873:Anthracenes; D014118:Toxins, Biological; D011407:Propane