[Effect of benzimidazole and its derivatives on electrical activity of Helix albescens Rossm neurons and behavior of rats].
We studied concentration dependency and the mechanisms of the effect of bezimidazole and its new derivatives on electrical processes in Helix albescens Rossm. neurons. These compounds appeared to have neurotropic properties dependent on their chemical structure and the types of neurons. We determined the threshold, optimal and toxic concentration values of the tested substances. Benzimidazole and 2-trifluoromethylbenzimidazole at concentrations of 10(-3) and 10(-2) M elicit both excitatory and inhibitory postsynaptic potentials on soma membrane of some pacemaker and non-pacemaker neurons and even cause a strong depolarization. The membrane of pacemaker neurons (namely, neuron RPa2) was found to have at least two spatially separated trigger sites with different trigger mechanism of action potential. After single intraperitoneal injection (50 mg/kg) of the substance solution, the tested compounds based on the discovered effects were separated into two groups. The first group inhibits locomotion and psychoemotional state of rats, the second group elicits the opposite effect. We found that at 100 and 150 mg/kg all tested substances inhibit the animal's activity.
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011619:Psychotropic Drugs / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D001562:Benzimidazoles; D011619:Psychotropic Drugs; C031000:benzimidazole