Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?
Anderson
Gail D
GD
Shen
Danny D
DD
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010641:Phenotype
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000927:Anticonvulsants