title: Synthesis and biological activity of phosphonocarboxylate DNA.
abstract: Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.
authors: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA. marvin.caruthers@colorado.edu
authors: Christina M
authors: CM
authors: Yamada
authors: Douglas J
authors: DJ
authors: Dellinger
authors: Marvin H
authors: MH
authors: Caruthers
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004951:Esterification; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D008055:Lipids / Q000737:chemistry; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D014162:Transfection
chemical_list: D008055:Lipids; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D012313:RNA; D004247:DNA; D010746:Phosphonoacetic Acid