A computer model of mammalian central CO2 chemoreception.
We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.
Chernov
Mykyta
M
Dartmouth Medical School, Department of Physiology, USA. mykyta.chernov@dartmouth.edu
Putnam
Robert W
RW
Leiter
J C
JC
D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D003198:Computer Simulation; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000502:physiology; D008322:Mammals / Q000502:physiology*; D009474:Neurons / Q000502:physiology
D007473:Ion Channels; D002245:Carbon Dioxide