title: Two new phenolic constituents of Humulus japonicus and their cytotoxicity test in vitro.
abstract: Two new phenolic constituents (4 and 6), together with four known constituents, methyl ferulate (1), eugenyl-beta-D-glucopyranoside (2), apigenin-7-O-beta-D-glucopyranoside (3), and (E)-resveratrol-3-O-beta-D-glucopyranoside (5) were isolated from the MeOH extract of the aerial part sof Humulus japonicus. The structures of the new compounds were determined by spectroscopic methods to be divarin-3-O-beta-glucopyranoside (4), and lariciresinol-9-O-beta-xylopyranoside (6). Compounds 1 and 3 exhibited moderate cytotoxicity against two human cancer cell lines (SK-OV-3 and HCT15) with ED50 values ranging from 8.84 to 8.79 microM.
authors: Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors: Byung Chul
authors: BC
authors: Yu
authors: Min Cheol
authors: MC
authors: Yang
authors: Kyu Ha
authors: KH
authors: Lee
authors: Ki Hyun
authors: KH
authors: Kim
authors: Sang Un
authors: SU
authors: Choi
authors: Kang Ro
authors: KR
authors: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000972:Antineoplastic Agents, Phytogenic