title: Interstitial pneumonitis associated with sirolimus in liver transplantation: a case report.
abstract: Sirolimus is a powerful immunosuppressive drug initially used in kidney transplant patients but now increasingly employed in recipients of other types of solid organ transplants, such as liver, heart, lung, or pancreas. Sirolimus is indicated for rescue therapy and to reduce the toxic side effects of calcineurin inhibitors. However, its use has been associated with an uncommon but important pulmonary toxicity. Reports have described interstitial pneumonitis, bronchiolitis obliterans, organizing pneumonia, and alveolar proteinosis. We present the case of a liver transplant patient with interstitial pneumonitis associated with sirolimus.
authors: Unidad de Hepatologia-Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Carlos Haya, Malaga, Spain. miguel.jimenez.sspa@juntadeandalucia.es
authors: M J
authors: MJ
authors: Pérez
authors: R O
authors: RO
authors: Martín
authors: D M
authors: DM
authors: García
authors: J M Lozano
authors: JM
authors: Rey
authors: J
authors: J
authors: de la Cruz Lombardo
authors: J M
authors: JM
authors: Rodrigo López
mesh_terms: D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D020123:Sirolimus