title: White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression.
abstract: Previous studies have demonstrated lower-diffusion anisotropy within white matter in late-onset depression measured by diffusion tensor imaging, which provides information about brain white matter integrity. We have examined whether white matter is abnormal in first-episode remitted geriatric depression by using diffusion tensor imaging. Sixteen remitted geriatric depression patients and 14 well matched healthy controls underwent diffusion tensor-imaging scans of magnetic resonance imaging, which were analyzed by a rigorous voxel-based approach. We found that fractional anisotropy in white matter was lower in patients than in controls at the right superior frontal gyrus, left inferior frontal gyrus, left middle temporal gyrus, right inferior parietal lobule, right middle occipital gyrus, left lingual gyrus, right putamen and right caudate. These results suggested that the white matter integrity of the whole brain was disrupted in first-episode remitted geriatric depression, and that these abnormalities were perhaps involved in the psychopathology and pathophysiology of cognitive impairment in remitted geriatric depression.
authors: School of Clinical Medicine, Southeast University, Nanjing, PR China.
authors: Yonggui
authors: Y
authors: Yuan
authors: Zhijun
authors: Z
authors: Zhang
authors: Feng
authors: F
authors: Bai
authors: Hui
authors: H
authors: Yu
authors: Yongmei
authors: Y
authors: Shi
authors: Yun
authors: Y
authors: Qian
authors: Yufeng
authors: Y
authors: Zang
authors: Caozhe
authors: C
authors: Zhu
authors: Wen
authors: W
authors: Liu
authors: Jiayong
authors: J
authors: You
mesh_terms: D000368:Aged / Q000502:physiology*; D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D004493:Education; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales