title: Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis.
abstract: We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy. Electronic address: nucciatesse@hotmail.com.
authors: Riccardina
authors: R
authors: Tesse
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Fabio
authors: F
authors: Cardinale
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Teresa
authors: T
authors: Santostasi
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Angela
authors: A
authors: Polizzi
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Luigi
authors: L
authors: Mappa
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Antonio
authors: A
authors: Manca
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Francesco
authors: F
authors: De Robertis
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Ombretta
authors: O
authors: Silecchia
authors: Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
authors: Lucio
authors: L
authors: Armenio
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011552:Pseudomonas Infections / Q000235:genetics / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D016753:Interleukin-10