title: Effect of low-intensity laser therapy on mast cell degranulation in human oral mucosa.
abstract: Little is known about the physiological mechanisms related to low-intensity laser therapy (LILT), particularly in acute inflammation and subsequent wound healing. The objective of this study was to verify the effect of LILT on mast cell degranulation. Epulis fissuratum tissues from eight patients were used. One part of the lesion was irradiated with an AsGaAl laser (lambda = 670 nm, 8.0 J/cm(2), 5 mW, 4 min). The other part was not irradiated. Then, the specimens were immediately removed, fixed and examined by light microscopy. The number of mast cells was similar in laser-treated samples when compared with non-irradiated specimens. The degranulation indexes of the mast cells observed in the irradiated samples were significantly higher than those of controls (P < 0.05). LILT with the parameters used increased the number of degranulated mast cells in oral mucosa.
authors: Department of Oral Pathology, School of Dentistry, Londrina State University, Londrina, Paraná, Brazil.
authors: Iris
authors: I
authors: Sawasaki
authors: Vinicius R
authors: VR
authors: Geraldo-Martins
authors: Martha S
authors: MS
authors: Ribeiro
authors: Márcia M
authors: MM
authors: Marques
mesh_terms: D000328:Adult; D015550:Cell Degranulation / Q000528:radiation effects*; D006801:Humans; D028022:Low-Level Light Therapy; D008407:Mast Cells / Q000528:radiation effects*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology* / Q000528:radiation effects*