Early detection and significance of structural cardiovascular abnormalities in patients with Type 2 diabetes mellitus.
Cardiovascular disease is the leading cause of death among patients with Type 2 diabetes mellitus. The main forms of structural heart disease associated with diabetes are coronary heart disease and diabetic cardiomyopathy, which is characterized by left ventricular hypertrophy, left ventricular diastolic and systolic dysfunction. Asymptomatic structural heart disease is common and associated with a poor prognosis in patients with diabetes. Contemporary practice guidelines do not recommend screening of asymptomatic individuals for structural heart disease. Potential screening modalities, such as echocardiography, are costly and inaccessible. A simple, inexpensive blood test for brain natriuretic peptide is a useful marker of structural heart disease and is a prime candidate for screening patients with Type 2 diabetes mellitus and prioritizing referral for echocardiography.
Somaratne
Jithendra B
JB
The University of Auckland, Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, Private Bag 92 019, Auckland, New Zealand. j.somaratne@auckland.ac.nz
Whalley
Gillian A
GA
Bagg
Warwick
W
Doughty
Robert N
RN
D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004452:Echocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain