CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.
Gerrard
Simon R
SR
School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom.
Srinivasan
Natarajan
N
Fox
Keith R
KR
Brown
Tom
T
D020029:Base Pairing; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D006860:Hydrogen Bonding; D009705:Nucleosides / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
C526848:N-methyl-3H-pyrrolo(2,3-d)pyrimidin-2(7H)-one; D009705:Nucleosides; D011744:Pyrimidinones; D011758:Pyrroles; C051802:triplex DNA; D006147:Guanine; D003596:Cytosine; D004247:DNA