Glucose neurotoxicity.
Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia--a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy.
Tomlinson
David R
DR
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. david.tomlinson@manchester.ac.uk
Gardiner
Natalie J
NJ
D000818:Animals; D003929:Diabetic Neuropathies / Q000209:etiology; D045604:Extracellular Fluid / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D020258:Neurotoxicity Syndromes / Q000209:etiology*
D005947:Glucose