title: Interactive effect of paraoxonase-1 Q192R polymorphism and smoking history on the lung function decline in grain workers.
abstract: OBJECTIVE
  This retrospective longitudinal study investigated the association between the Q192R polymorphism of the high-density lipoprotein-associated multifunctional antioxidant enzyme, paraoxonase-1 (PON1), and lung function decline, while taking into account smoking history.
  
  
  METHODS
  The demographic, occupational, and respiratory symptom information and lung function variables were obtained from 216 male Saskatchewan grain workers.
  
  
  RESULTS
  An interaction between the PON1 genotypes and smoking status was observed. Current smokers with the 192R allele had a lower forced expiratory volume in the first second (FEV(1)) and FEV(1) per forced vital capacity (FVC). The annual decline rate of FEV(1)/FVC in current smokers was greater among 192R allele carriers than noncarriers (0.58+/-0.05 vs. 0.35+/-0.04 %/yr, p<0.0001). A similar result was observed with FEV(1) (40.9+/-6.4 vs. -33.0+/-7.0 mL/yr, p=0.10). The annual decline rate of FVC was not influenced by the genotypes.
  
  
  CONCLUSIONS
  These results strengthened the previous findings of our cross-sectional study, suggesting that the 192R allele may be a novel genetic risk factor for airway injury among current smokers.
authors: Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
authors: Takayuki
authors: T
authors: Seo
authors: Punam
authors: P
authors: Pahwa
authors: Helen H
authors: HH
authors: McDuffie
authors: Naoyuki
authors: N
authors: Nakada
authors: Shuji
authors: S
authors: Goto
authors: Sunita
authors: S
authors: Ghosh
authors: Kazuko
authors: K
authors: Nakagawa
mesh_terms: D000328:Adult; D000383:Agriculture; D043303:Aryldialkylphosphatase / Q000235:genetics*; D002523:Edible Grain; D005541:Forced Expiratory Volume; D005973:Glutamine; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012525:Saskatchewan; D012907:Smoking / Q000453:epidemiology* / Q000235:genetics; D014481:United States / Q000453:epidemiology
chemical_list: D005973:Glutamine; D043303:Aryldialkylphosphatase