title: Discovery of a novel class of selective human CB1 inverse agonists.
abstract: Ligand-based virtual screening led to the discovery of a new class of potent inverse agonists of the human cannabinoid receptor 1, hCB(1), which are selective versus hCB(2). These CB(1) ligands present intriguing departures from a classical CB(1) antagonist pharmacophore. Elements of SAR are discussed in this context.
authors: Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge CB21 6GB, UK. n.foloppe@vernalis.com
authors: Nicolas
authors: N
authors: Foloppe
authors: Nicola H
authors: NH
authors: Allen
authors: Carol H
authors: CH
authors: Bentley
authors: Teresa D
authors: TD
authors: Brooks
authors: Guy
authors: G
authors: Kennett
authors: Antony R
authors: AR
authors: Knight
authors: Stefania
authors: S
authors: Leonardi
authors: Anil
authors: A
authors: Misra
authors: Nathaniel J T
authors: NJ
authors: Monck
authors: Daniel M
authors: DM
authors: Sellwood
mesh_terms: D002186:Cannabinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists*; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists; D013329:Structure-Activity Relationship
chemical_list: D002186:Cannabinoids; D008024:Ligands; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2