The association between the IFIH1 locus and type 1 diabetes.
OBJECTIVE
We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent.


METHODS
We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and rs984971589, in 589 type 1 diabetes nuclear family trios (1,767 individuals).


RESULTS
This study independently replicated the reported genetic association using a family-based approach.


CONCLUSIONS
The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, i.e. FAP, IFIH1 and GCA. Further variant discovery and fine mapping could help clarify a novel type 1 diabetes mechanism.
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Endocrine Genetics Lab, The McGill University Health Center (Montreal Children's Hospital), 2300 Tupper, Montreal, QC, Canada, H3H 1P3.
Marchand
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Grabs
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Polychronakos
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D000951:Antigens, Neoplasm / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D010450:Endopeptidases; D051638:Ether-A-Go-Go Potassium Channels / Q000235:genetics; D005260:Female; D018093:Gelatinases; D014644:Genetic Variation; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D008297:Male; D008565:Membrane Proteins; D009679:Nuclear Family; D012697:Serine Endopeptidases / Q000235:genetics*; D044465:White People / Q000235:genetics; D000099167:Fibroblast Activation Protein Alpha
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D053487:DEAD-box RNA Helicases; D010450:Endopeptidases; D051638:Ether-A-Go-Go Potassium Channels; D018093:Gelatinases; D000072640:Interferon-Induced Helicase, IFIH1; D008565:Membrane Proteins; D012697:Serine Endopeptidases; D000099167:Fibroblast Activation Protein Alpha; C503121:GCA protein, human; C486376:KCNH7 protein, human; C452815:IFIH1 protein, human