title: Use of a SQUID array to detect T-cells with magnetic nanoparticles in determining transplant rejection.
abstract: Acute rejection in organ transplant is signaled by the proliferation of T-cells that target and kill the donor cells requiring painful biopsies to detect rejection onset. An alternative non-invasive technique is proposed using a multi-channel superconducting quantum interference device (SQUID) magnetometer to detect T-cell lymphocytes in the transplanted organ labeled with magnetic nanoparticles conjugated to antibodies specifically attached to lymphocytic ligand receptors. After a magnetic field pulse, the T-cells produce a decaying magnetic signal with a characteristic time of the order of a second. The extreme sensitivity of this technique, 10(5) cells, can provide early warning of impending transplant rejection and monitor immune-suppressive chemotherapy.
authors: Senior Scientific, 11109 Country Club NE, Albuquerque, NM 87111, USA.
authors: Edward R
authors: ER
authors: Flynn
authors: H C
authors: HC
authors: Bryant
authors: Christian
authors: C
authors: Bergemann
authors: Richard S
authors: RS
authors: Larson
authors: Debbie
authors: D
authors: Lovato
authors: Dmitri A
authors: DA
authors: Sergatskov