title: Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement.
abstract: This study describes the preparation of an oridonin (ORI) nanosuspension by high-pressure homogenization (HPH). The aim was to obtain a stable nanosuspension with an increased drug saturation solubility and dissolution velocity. The homogenization procedure was optimized in regard to particle size and long-term stability. The characteristics of the oridonin nanosuspension, such as particle size, size distribution, shape, and zeta potential, were evaluated following the water removal. The solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with commercial ORI. Finally, crystalline state evaluation before and following the formulation was performed through differential scanning calorimetry (DSC) and powder X-ray (PXRD).
authors: Department of Pharmaceutics, College of Pharmacy, Shandong University, China.
authors: Lei
authors: L
authors: Gao
authors: Dianrui
authors: D
authors: Zhang
authors: Minghui
authors: M
authors: Chen
authors: Tingting
authors: T
authors: Zheng
authors: Shumei
authors: S
authors: Wang
mesh_terms: D004224:Diterpenes / Q000008:administration & dosage* / Q000737:chemistry; D045786:Diterpenes, Kaurane / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles; D010316:Particle Size; D012995:Solubility; D013535:Suspensions
chemical_list: D004224:Diterpenes; D045786:Diterpenes, Kaurane; D013535:Suspensions; C011959:oridonin