[Acute phase response following total hip replacement and in patients with aseptic loosening].
BACKGROUND
Aseptic loosening is a result of the chronic inflammatory reaction in periprosthetic tissues. Its intensity depends on the implants construction material and reactivity of the host's tissues. The aim of the study was the evaluation of the acute phase proteins in various periods following total hip replacement and comparison between acute phase response observed in patients with well-functioning implants and with aseptic loosening.


METHODS
The study group consisted of 97 patients following THR due to the hip osteoarthritis. Patients of Group I were evaluated before the surgery and 6 months after primary THR. Group II consisted of patients 3-4 years after primary THR. Group consisted of patients with aseptic loosening. Patients of all groups were divided according to the implant type (cemente/uncemented).


METHODS
Concentrations of evaluated acute phase proteins: C-reactive protein (CRP), transferrin (Tf) and alpha-glycoprotein were assessed using immunoelectrophoresis.


RESULTS
In vast majority of patients (71-95%) following THR had present w3 variant of AGP which should be negative in physiological conditions. The average concentrations of AGP and AGP-RC were higher in patients following cemented THR.


CONCLUSIONS
Implantation of the endoprosthesis raises a chronic inflammatory reaction expressed by changes in the profiles of acute phase proteins. This process is more visible in patients following cemented THR. The profiles of the acute phase proteins in patients with aseptic loosening were not different than those observed in patients with well-functioning implants, what makes them useless as a diagnostic tool for loosening. This lack of differences may be caused by adaptation of the generalised response to long lasting process of aseptic loosening
Markuszewski
Jacek
J
Klinika Ortopedii Ogólnej, Onkologicznej i Traumatologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu.
Wierusz-Kozłowska
Małgorzata
M
Woźniak
Waldemar
W
Leśniewska
Kinga
K
Sobieska
Magdalena
M
D000209:Acute-Phase Proteins / Q000032:analysis*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D015207:Osteoarthritis, Hip / Q000601:surgery*; D011475:Prosthesis Failure; D014168:Transferrin / Q000032:analysis
D000209:Acute-Phase Proteins; D006023:Glycoproteins; D014168:Transferrin; D002097:C-Reactive Protein