Enamel mineral concentration in diabetic rodents.
OBJECTIVE
This was to use x-ray microtomography (XMT), to assess the mineral composition and 3-D structure of enamel and bone in the teeth and skulls of diabetic rodents.


METHODS
Three-dimensional images of the skull were reconstructed using computer generated false colour to highlight different levels of mineralization in bone and enamel.


RESULTS
These showed that diabetic rodents exhibited more wear in their teeth. Deformities were observed in the alveolar process of the mandible and maxilla. Regions of extensive hypomineralization were found in the calvarial bone of skulls. The maximum mineral concentrations and the time constants for diabetic rodents were similar to the controls. The diabetic mice appeared to have random regions of hypomineralization and one diabetic rat had areas of hypoplasia in the mandibular incisors.


CONCLUSIONS
Diabetes may have a detrimental influence on the function of ameloblasts in laying down enamel.
Atar
M
M
Dept. Oral Growth and Developement, Section of Paediatric Dentistry, Barts and The London, Queen Mary University of London, School of Medicine and Dentistry, London, England. atardrs@yahoo.com
Davis
G R
GR
Verry
P
P
Wong
F S L
FS
D000539:Alveolar Process / Q000737:chemistry; D000818:Animals; D002113:Calcification, Physiologic; D002118:Calcium / Q000032:analysis; D003743:Dental Enamel / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology*; D007180:Incisor / Q000737:chemistry; D051379:Mice; D008963:Molar / Q000737:chemistry; D051381:Rats; D012886:Skull / Q000737:chemistry; D014056:Tomography, X-Ray; D014074:Tooth Calcification
D002118:Calcium