One step conversion of heteroaromatic-N-oxides to imidazolo-heteroarenes.
Various pyridine-, quinoline-, isoquinoline-, and pyrimidine-N-oxides were converted to their corresponding alpha-imidazoloheteroarenes in good yield by treatment with sulfuryl diimidazole in nonpolar solvents at elevated temperatures.
Keith
John M
JM
Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA. jkeith@prdus.jnj.com
D003497:Cyclic N-Oxides / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D003497:Cyclic N-Oxides; D007093:Imidazoles; D013438:Sulfhydryl Compounds