Aqueous humor erythropoietin levels in patients with primary open-angle glaucoma.
OBJECTIVE
To evaluate the levels of erythropoietin (EPO) in the aqueous humor in eyes with primary open-angle glaucoma (POAG) and without glaucoma.


METHODS
Levels of EPO were measured using a sandwich enzyme-linked immunosorbent assay kit in aqueous humor aspirates taken during anterior segment surgery from 45 patients, of whom 20 had POAG and 25 had senile cataract only.


RESULTS
The mean aqueous humor EPO concentration in eyes with POAG (10.91+/-4.32 mU/mL) was significantly higher than that from eyes with cataract (8.24+/-1.77 mU/mL, P=0.008). There was no significant difference between the serum EPO concentrations of POAG (26.46+/-10.36 mU/mL) and the control group (24.50+/-7.59 mU/mL, P=0.468). There was no correlation (P=0.165) between the EPO aqueous humor concentration and the EPO serum concentration while there was no correlation between the EPO aqueous humor concentration and the EPO serum concentration in the control group (P=0.819).


CONCLUSIONS
The aqueous humor EPO level is increased in eyes with POAG.
Cumurcu
Tongabay
T
Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. tcumurcu@gop.edu.tr
Bulut
Yunus
Y
Demir
Helin Deniz
HD
Yenisehirli
Gulgun
G
D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D016022:Case-Control Studies; D002386:Cataract / Q000097:blood / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood / Q000378:metabolism*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010865:Pilot Projects; D011446:Prospective Studies
D004921:Erythropoietin