Biodegradable microcapsules designed via 'click' chemistry.
Dextrans modified with alkyne and azide groups through hydrolysable carbonate esters form degradable microcapsules after Cu(I) catalysed 'click' reaction between azides and alkynes yielding triazole cross-links.
De Geest
Bruno G
BG
Department of Pharmaceutics, Utrecht University, 3584 CA Utrecht, The Netherlands. br.degeest@ugent.be
Van Camp
Wim
W
Du Prez
Filip E
FE
De Smedt
Stefaan C
SC
Demeester
Jo
J
Hennink
Wim E
WE
D002214:Capsules / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D002244:Carbon / Q000737:chemistry; D003911:Dextrans / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D013055:Spectrophotometry, Infrared
D002214:Capsules; D003911:Dextrans; D002244:Carbon; D009584:Nitrogen