[Expression and clinical significance of matrix metalloproteinase in gastric stromal tumor].
OBJECTIVE
To investigate the expression and clinical significance of matrix metalloproteinase (MMP) in gastric stromal tumor (GST).


METHODS
MMP-2 and MMP-9 expression were determined by immunohistochemistry in tumor tissues in 44 patients with GST, and their relationship with clinicopathologic factors of the neoplasm was also investigated.


RESULTS
MMP-2 and MMP-9 were expressed in the cytoplasm in 84.1% (37/44) and 81.8% (36/44) of tumors, respectively. The positive rates of MMP-2 and MMP-9 increased significantly in parallel to the increase in tumor malignancy (P < 0.05) and associated with pattern of tumor growth, tumor size, and centre necrosis (P < 0.05). In addition, there was a statistically significant positive correlation between the expression of the two markers in GST (r = 0.6523, P < 0.05). Furthermore, the 5-year postoperative survival rates of patients with positive expressions of MMP-2 and MMP-9 were significantly lower than those of patients with negative expressions of the two markers (P < 0.05).


CONCLUSIONS
Over expression of MMP-2 and MMP-9 can be served as objective markers to judge the malignant degree and, to predict the prognosis of patients with GST.
Miao
Rui-zheng
RZ
Department of General Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China. miaoruizheng123@sina.com
Li
Yue-ping
YP
Wang
Yong-kang
YK
Yu
Xiao-bo
XB
Zhang
Min
M
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9