title: Evaluation of secondary hyperparathyroidism in patients undergoing hemodialysis.
abstract: Renal osteodystrophy is a complication of chronic kidney disease (CKD) that present in low and high turnover patterns. This disorder has a key role in the disability of CKD patients in whom early diagnosis and treatment can result in better outcome. We studied hyperparathyroidism prevalence and its relationship with renal osteodystrophy in our advanced CKD population. We included 80 patients (of whom 44 (55%) were diabetic) during 6 months period. The patients answered a questionnaire about symptoms related to bone disease and blood levels of parathormone (PTH), calcium, phosphorus, and alkaline phosphatase were obtained, in addition to hand and skull radiographs in all the study patients. Prevalence of clinically evident hyperparathyroidism in our patients was 45%. Hyperparathyroidism had significant relationship with alkaline phosphatase and radiological findings, but did not have a significant relationship with dialysis duration, age, sex, familial history, diabetes mellitus, or hypertension. We conclude that secondary hyperparathyroidism is prevalent in our dialysis population and has high correlation with serum alkaline phosphatase levels and radiological changes.
authors: Department of Medicine, Division of Nephrology, Shahid Rahnemoon Hospital, Yazd Medical University, Iran. rahimian@irangene.ir
authors: Mohammad
authors: M
authors: Rahimian
authors: Ramin
authors: R
authors: Sami
authors: Fariba
authors: F
authors: Behzad
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001847:Bone Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D000469:Alkaline Phosphatase