Metabolic and immunological features of the failing islet-transplanted patient.
OBJECTIVE
This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure.


METHODS
We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx).


RESULTS
The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure.


CONCLUSIONS
Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.
Fiorina
Paolo
P
Department of Medicine, San Raffaele Scientific Institute, Milan, Italy.
Vergani
Andrea
A
Petrelli
Alessandra
A
D'Addio
Francesca
F
Monti
Lucilla
L
Abdi
Reza
R
Bosi
Emanuele
E
Maffi
Paola
P
Secchi
Antonio
A
D000328:Adult; D017304:Annexin A5 / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D053222:Fas Ligand Protein / Q000378:metabolism; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D006085:Graft Survival; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016381:Islets of Langerhans Transplantation; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors
D017304:Annexin A5; D002096:C-Peptide; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007328:Insulin