Developing the science base for reducing tobacco harm.
The University of Minnesota Transdisciplinary Tobacco Use Research Center has been examining the multiple dimensions and the scientific evidence required to determine the feasibility of tobacco harm reduction as a means to reduce tobacco-related mortality and morbidity. Because of the complexity associated with exploring this area, an interdisciplinary approach is necessary. The research components that have been of particular focus at our center include (a) developing and validating biomarkers of tobacco-related exposure and toxicity, (b) developing animal models and designing studies with humans to assess a variety of smoking reduction approaches and potential reduced exposure products, and (c) determining individual differences in response to these interventions and products. A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future.
Hatsukami
Dorothy K
DK
University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA. hatsu001@umn.edu
Joseph
Anne M
AM
Lesage
Mark
M
Jensen
Joni
J
Murphy
Sharon E
SE
Pentel
Paul R
PR
Kotlyar
Michael
M
Borgida
Eugene
E
Le
Chap
C
Hecht
Stephen S
SS
D006801:Humans; D008962:Models, Theoretical; D040242:Risk Reduction Behavior; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation; D014026:Nicotiana