title: Role of arginine metabolism in immunity and immunopathology.
abstract: A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of the amino acid l-arginine. Myeloid cells exert various, often divergent, actions on the immune response through mechanisms that exploit mediators of this peculiar metabolic pathway, ranging from l-arginine itself to its downstream metabolites, like nitric oxide and polyamines. Various pathological situations, including neoplastic and autoimmune diseases, as well as injury repair and infections are discussed here, showing how l-arginine metabolism is able to play a dual role, both as an active protector and a possible threat to the organism.
authors: Department of Oncology and Surgical Sciences, Padova University, via Gattamelata 64, 35128, Padova, Italy.
authors: Elisa
authors: E
authors: Peranzoni
authors: Ilaria
authors: I
authors: Marigo
authors: Luigi
authors: L
authors: Dolcetti
authors: Stefano
authors: S
authors: Ugel
authors: Nada
authors: N
authors: Sonda
authors: Elisa
authors: E
authors: Taschin
authors: Barbara
authors: B
authors: Mantelli
authors: Vincenzo
authors: V
authors: Bronte
authors: Paola
authors: P
authors: Zanovello
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism; D001120:Arginine / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007109:Immunity; D007110:Immunity, Active; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D014945:Wound Healing
chemical_list: D016207:Cytokines; D001120:Arginine; D019001:Nitric Oxide Synthase; D001119:Arginase