title: C-reactive protein associated with periodontitis in a Thai population.
abstract: OBJECTIVE
  C-reactive protein (CRP) has been implicated as a possible mediator of the association between periodontitis and several systemic diseases. Previous studies suggest an association between increased CRP levels and periodontitis predominantly in Caucasians. This study evaluated the associations of chronic periodontitis and Porphyromonas gingivalis with CRP in systemically healthy Thai adults.
  
  
  METHODS
  Serum high-sensitivity CRP was measured in 21 generalized periodontitis, 62 localized periodontitis, and 38 periodontally healthy control subjects. P. gingivalis in subgingival plaque samples was analyzed by polymerase chain reaction.
  
  
  RESULTS
  Overall, these subjects had a median CRP level lower than that reported in the western populations. Subjects with generalized periodontitis and localized periodontitis had higher median CRP levels than controls (1.78 and 0.65 mg/l versus 0.25 mg/l, p<0.001). Multivariate linear regression showed that log CRP levels were increased in subjects with generalized periodontitis (p<0.01) and localized periodontitis (p=0.03) compared with the controls, adjusted for age, body mass index and smoking. Presence of P. gingivalis was also independently associated with elevated log CRP levels (p<0.001).
  
  
  CONCLUSIONS
  Periodontitis and subgingival P. gingivalis are associated with increased CRP levels. These findings suggest that periodontal infection may contribute to systemic inflammatory burden in otherwise healthy individuals.
authors: Department of Community Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. waranuch@post.harvard.edu
authors: Waranuch
authors: W
authors: Pitiphat
authors: Warangrat
authors: W
authors: Savetsilp
authors: Nawarat
authors: N
authors: Wara-Aswapati
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003773:Dental Plaque / Q000382:microbiology; D004522:Educational Status; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification*; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013785:Thailand
chemical_list: D002097:C-Reactive Protein