title: GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families.
abstract: We investigated the relationship of the gene for the X-linked orphan G protein-coupled receptor (GPR50) to childhood-onset mood disorders in a sample of 384 families with 468 affected children and adolescents collected in Hungary. Our choice of this gene for study was based on a previous report of an association of GPR50 with bipolar disorder and major depressive disorder. A significant association with the deletion allele of an insertion/deletion polymorphism (Delta502-505) located in exon 2 had been reported in a sample of 226 patients with major depressive disorder and 264 patients with bipolar disorder. The association was more significant in females compared with males in those samples. We used for this study a polymorphism in complete linkage disequilibrium with the Delta502-505 polymorphism, Thr532Ala (rs561077), and two additional polymorphisms, Val606Ile (rs13440581) and an intronic polymorphism (rs2072621). We found no evidence for an association for the markers analyzed individually, nor for haplotypes of these markers. Further, we found no evidence of association when the results were analyzed in girls only (n=215). We, therefore, failed to replicate the previous association of this gene with mood disorders.
authors: Toronto Western Research Institute, University Health Network, Ontario, Canada.
authors: Yu
authors: Y
authors: Feng
authors: Karen
authors: K
authors: Wigg
authors: Nicole
authors: N
authors: King
authors: Agnes
authors: A
authors: Vetró
authors: Eniko
authors: E
authors: Kiss
authors: Krisztina
authors: K
authors: Kapornai
authors: László
authors: L
authors: Mayer
authors: Júlia
authors: J
authors: Gádoros
authors: James L
authors: JL
authors: Kennedy
authors: Maria
authors: M
authors: Kovacs
authors: Cathy L
authors: CL
authors: Barr
mesh_terms: D017668:Age of Onset; D019943:Amino Acid Substitution; D002648:Child; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X; D003866:Depressive Disorder / Q000235:genetics; D005091:Exons; D005260:Female; D006801:Humans; D006814:Hungary; D015810:Linkage Disequilibrium; D008297:Male; D019964:Mood Disorders / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion; D012727:Sex Characteristics; D044465:White People / Q000235:genetics
chemical_list: C509754:GPR50 protein, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled