title: In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds.
abstract: Against 182 anaerobe and 241 aerobe strains obtained from diabetic foot infections, doripenem was the most active carbapenem against Pseudomonas aeruginosa (MIC(90), 2 microg/ml), more active than imipenem against Proteus mirabilis, and ertapenem was more active against Escherichia coli and Klebsiella spp. The MIC(50) and MIC(90) values were < or =0.125 microg/ml for methicillin-sensitive Staphylococcus aureus and all streptococci and 0.25/1 for Bacteroides fragilis.
authors: R M Alden Research Laboratory, 2021 Santa Monica Blvd., 740 East, Santa Monica, CA 90404, USA. ejcgmd@aol.com
authors: Ellie J C
authors: EJ
authors: Goldstein
authors: Diane M
authors: DM
authors: Citron
authors: C Vreni
authors: CV
authors: Merriam
authors: Yumi A
authors: YA
authors: Warren
authors: Kerin L
authors: KL
authors: Tyrrell
authors: Helen T
authors: HT
authors: Fernandez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology*; D015780:Carbapenems / Q000494:pharmacology*; D017719:Diabetic Foot / Q000150:complications*; D000077726:Doripenem; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem