Long-term persistence of memory B cells specific for hepatitis B surface antigen in HIV-1-infected patients.
To investigate the maintenance of long-term memory B cells specific for hepatitis B surface antigen (HBsAg), purified blood B cells were polyclonally stimulated and cells secreting antibodies directed to HBsAg (HBs-SC) enumerated by ELISpot. HBs-SC were found in 18/20 HIV-1-infected patients with either natural or vaccinal immunity to hepatitis B virus, including six subjects with serum anti-hepatitis B surface antibody levels less than 10 mIU/ml. A lower number of HBs-SC was found in HBsAg-vaccinated patients compared with vaccinated controls.
Tuaillon
Edouard
E
Laboratoire de Virologie, Hôpital Lapeyronie, Montpellier, France.
Tabaa
Yassine Al
YA
Baillat
Vincent
V
Petitjean
Gaël
G
Reynes
Jacques
J
Vendrell
Jean Pierre
JP
D019380:Anti-HIV Agents / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology* / Q000821:virology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D018709:Statistics, Nonparametric; D013997:Time Factors
D019380:Anti-HIV Agents; D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines