[Identification and susceptibility against fluconazole and albaconazole of 100 yeasts' strains isolated from vaginal discharge].
Vulvovaginal candidiasis is a condition that affects a great number of fertile women. It is considered the second cause of genital infection after vaginosis due to GAM complex. Candida albicans is the most frequent isolated species from vaginal discharge. However, sometimes more than one yeast species could be found in the same clinical sample that are more resistant to antifungal drugs. Nowadays, it is necessary to identify properly up to species level the isolated microorganism and to determine the antifungal susceptibility profile. One hundred strains obtained from vaginal discharge of 94 patients suffering acute vulvovaginal candidiasis were studied. The identification of the isolates showed: C. albicans 86%, Candida glabrata 6%, Candida inconspicua 3%, Candida krusei 2% and Candida intermedia, Candida holmii and Trichosporon asahii one case each. Minimal inhibitory concentrations (MIC) of all the yeasts against fluconazole and albaconazole were performed. C. glabrata, C. krusei and C. inconspicua were the most resistant against fluconazole, on the other hand albicans was susceptible to this drug. All the isolates presented MIC against albaconazole much lower than fluconazole.
Arechavala
Alicia I
AI
Unidad Micología, Hospital de Infecciosas F.J. Muñiz, Buenos Aires, Argentina. hmmicologia@intramed.net
Bianchi
Mario H
MH
Robles
Ana María
AM
Santiso
Gabriela
G
Negroni
Ricardo
R
D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D001826:Body Fluids / Q000382:microbiology*; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011799:Quinazolines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology*
D000935:Antifungal Agents; D011799:Quinazolines; D014230:Triazoles; D015725:Fluconazole; C112424:albaconazole