title: Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
abstract: We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.
authors: Avrom J
authors: AJ
authors: Caplan
authors: Avi
authors: A
authors: Ma'ayan
authors: Ian M
authors: IM
authors: Willis
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C513270:CDC37 protein, S cerevisiae; D018797:Cell Cycle Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D010770:Phosphotransferases