Highly effective non-explosive activators based on saccharin for the synthesis of oligonucleotides and phosphoramidites.
A new class of non-explosive activators has been developed based on heterocyclic tertiary amine salts of saccharin. These salts have been found to be highly effective in the synthesis of oligonucleotides and nucleoside phosphoramidites.
Sinha
Nanda D
ND
Avecia Biotechnology Inc., 125 Fortune Boulevard, Milford, MA 01757, USA. Nanda.Sinha@Avecia.com
Foster
Patrick
P
Kuchimanchi
Satya N
SN
Miranda
Greg
G
Shaikh
Saied
S
Michaud
Dennis
D
D053834:Explosive Agents / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D012439:Saccharin / Q000031:analogs & derivatives* / Q000737:chemistry
D053834:Explosive Agents; D006571:Heterocyclic Compounds; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012439:Saccharin