Identification of the novel HLA-C allele Cw*0751.
We report the novel HLA-Cw allele HLA-Cw*0751. The allele was identified during routine sequence-based typing in our laboratory. The novel allele is identical to Cw*07020101 except for a single nucleotide change in codon 90.2 in position 268. HLA-Cw*0751 allele possesses an adenine at position 268 in exon 2, while HLA-Cw*07020101 has a cytosine at this position. Although this substitution does not change serologic reactivity of HLA-Cw7 molecule, it changes the amino acid at codon 90 from an aspartic acid to an alanine. Aspartic acid is polar and acidic, while alanine is non-polar and neutral.
Thompson
E M
EM
Kashi Clinical Laboratories, Beaverton, OR 97008, USA. ethompson@kashilab.com
Kashi
Z M
ZM
Martin
R K
RK
Alcorn
J L
JL
Tidey
L
L
D000225:Adenine / Q000737:chemistry; D000483:Alleles; D019943:Amino Acid Substitution; D003596:Cytosine / Q000737:chemistry; D015236:HLA-C Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans
D015236:HLA-C Antigens; C527712:HLA-C*07:51 antigen; D003596:Cytosine; D000225:Adenine