title: Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma.
abstract: The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA-B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis-free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II.
authors: Department of Radiation Oncology, Medisch Spectrum Twente, Enschede, The Netherlands. j.jobsen@ziekenhuis-mst.nl
authors: J J
authors: JJ
authors: Jobsen
authors: M L M
authors: ML
authors: Lybeert
authors: E M
authors: EM
authors: van der Steen-Banasik
authors: A
authors: A
authors: Slot
authors: J
authors: J
authors: van der Palen
authors: L N
authors: LN
authors: Ten Cate
authors: A
authors: A
authors: Scholten
authors: V
authors: V
authors: Coen
authors: E M J
authors: EM
authors: Schutter
authors: S
authors: S
authors: Siesling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate