title: The Generation R Study Biobank: a resource for epidemiological studies in children and their parents.
abstract: The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
authors: The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl
authors: Vincent W V
authors: VW
authors: Jaddoe
authors: Rachel
authors: R
authors: Bakker
authors: Cock M
authors: CM
authors: van Duijn
authors: Albert J
authors: AJ
authors: van der Heijden
authors: Jan
authors: J
authors: Lindemans
authors: Johan P
authors: JP
authors: Mackenbach
authors: Henriëtte A
authors: HA
authors: Moll
authors: Eric A P
authors: EA
authors: Steegers
authors: Henning
authors: H
authors: Tiemeier
authors: Andre G
authors: AG
authors: Uitterlinden
authors: Frank C
authors: FC
authors: Verhulst
authors: Albert
authors: A
authors: Hofman
mesh_terms: D000328:Adult; D018070:Biological Specimen Banks; D015331:Cohort Studies; D004247:DNA / Q000032:analysis; D016208:Databases, Factual; D004777:Environment; D005260:Female; D047109:Fetal Development / Q000235:genetics / Q000502:physiology*; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics; D006130:Growth Disorders / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006803:Human Development; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D004247:DNA