title: Brain metastases from breast cancer: management approach.
abstract: Brain metastases are a significant cause of morbidity and mortality in patients with breast cancer. HER-2 positivity is an increasingly recognized risk factor for the development of brain metastases. Although considerable progress has been made in the treatment of this complication, supportive measures like steroids, anti-seizure medication and whole-brain radiation remain the cornerstones of management in the majority of patients. The current review discusses the above and other issues like surgical excision, stereotactic radiotherapy, adjuvant radiation, radiosensitization and chemotherapy. A brief discussion of the recent evidence for the use of 'HER-1/ HER-2'-targeted therapy is also present.
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Tabassum
authors: T
authors: Wadasadawala
authors: Sudeep
authors: S
authors: Gupta
authors: Vaishali
authors: V
authors: Bagul
authors: Namrata
authors: N
authors: Patil
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans