title: [rhIL-11 accelerates the engraftment of platelets after unrelated cord blood transplantation].
abstract: OBJECTIVE
  To observe whether rhIL-11 could accelerate the engraftment of platelets after unrelated cord blood transplantation (CBT).
  
  
  METHODS
  Nine patients (3 children and 6 adults) were enrolled in this study. The degree of HLA disparity was 0-2 loci. Cord blood was given two units for adults and one unit for children. Conditioning regimens were CY/TBI in 1 and BU/CY in 8 cases, both with antithymocyte globulin. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and short-term methotrexate. On day +1, rhIL-11 was used at 50 microg x kg(-1) x d(-1) and G-CSF at 5 microg x kg(-1) x d(-1) to accelerate hematopoiesis recovery.
  
  
  RESULTS
  The median age of the patients was 22.3 years and the median weight 52.3 kg. Among the 9 patients, 8 (88.9%) experienced engraftment. The median time to neutrophil > 0.5 x 10(9)/L was 21.3 (14-37) days and to platelet > 20 x 10(9)/L was 25 (18-36) days. 42.9% of the patients developed grade I aGVHD and 33.3% developed localized chronic GVHD. Six patients were alive and disease-free at a median follow-up of 7 months. Infection was the primary cause of death. The expected 1-year survival was 77.8%, 2-year survival was 52.2%. Five of 8 patients (62.5%) who received IL-11 presented leakage syndrome. On prophylaxis with drugs containing Arnebia root extract, all patients could tolerate the treatment.
  
  
  CONCLUSIONS
  rhIL-11 maybe helpful for accelerating the platelet recovery and reducing aGVHD severity in unrelated CBT. The major side effect is leakage syndrome. It is well tolerated on prophylaxis with drugs containing Arnebia root.
authors: Department of Hematology, Peking University First Hospital, Beijing, China.
authors: Mang-ju
authors: MJ
authors: Wang
authors: Han-yun
authors: HY
authors: Ren
authors: Xi-nan
authors: XN
authors: Cen
authors: Zhi-xiang
authors: ZX
authors: Qiu
authors: Wei-lin
authors: WL
authors: Xu
authors: Jin-ping
authors: JP
authors: Ou
authors: Yuan
authors: Y
authors: Li
authors: Wen-sheng
authors: WS
authors: Wang
authors: Li-hong
authors: LH
authors: Wang
authors: Yong-jin
authors: YJ
authors: Shi
authors: Qiang
authors: Q
authors: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D017370:Interleukin-11 / Q000494:pharmacology*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D017370:Interleukin-11; D011994:Recombinant Proteins