[Study of a role of the expression of a transmembranous CD117/C-Kit receptor in the progression of uveal melanomas].
The authors studied the expression of the protooncogen receptor involved in the regulation of major cell cycle processes in uveal melanoma. The studies performed by a highly sensitive immunohistochemical technique. The findings have allowed the authors to state that the membranous CD117/C-Kit receptor plays an important role in the progression of uveal melanomas. It is suggested that the use of the new drug Glivec is promising in treating uveal melanoma.
Anurova
O A
OA
Likhvantseva
V G
VG
Vereshchagina
M V
MV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D018450:Disease Progression; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D014604:Uveal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit