title: [Preparation of puerarin liposome and its oral absorption in rat].
abstract: OBJECTIVE
  To prepare puerarin liposome and study its oral absorption in rat.
  
  
  METHODS
  Liposome was prepared through the way of film dispersion-ultrasonic. Free puerarin in liposome suspension was separated from liposome through ultrafiltration, and then encapsulation ratio of liposome was determined. Micro-morphology of liposme particles was observed under electronic transmission microscope. Puerarin concentration in blood was determined by HPLC.
  
  
  RESULTS
  The encapsulation ratio of puerarin in liposome was 53%, and liposome particles were global or elliptical. The diameter range of liposome particies was from 50 nm to 300 nm. The relative availability of puerarin liposme suspension to puerarin solution was 168%.
  
  
  CONCLUSIONS
  Liposome as a drug carrier can enhance the oral absorption of puerarin in rat.
authors: Qilu Hospital, Shandong University, Jinan 250012, China.
authors: Yi-zhu
authors: YZ
authors: Gu
authors: Wen
authors: W
authors: Zhou
authors: Guang-xi
authors: GX
authors: Zhai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions; D007887:Fabaceae / Q000737:chemistry; D007529:Isoflavones / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004655:Emulsions; D007529:Isoflavones; D008081:Liposomes; D014665:Vasodilator Agents; C033607:puerarin