title: Improved results with single-stage total correction of Taussig-Bing anomaly.
abstract: OBJECTIVE
  The arterial-switch operation (ASO) for management of Taussig-Bing anomaly is associated with important morbidity, mainly related to multiple associated cardiac anomalies. Our surgical management has evolved to suggest a single-stage total repair strategy tailored to address all abnormalities on an individual basis. We examine the efficacy of this treatment approach.
  
  
  METHODS
  Thirty-three children, (infants n=29), with Taussig-Bing underwent ASO (1979-2005). In our earlier experience (group 1, n=17), initial palliation was performed as needed, including pulmonary-artery banding (n=9), coarctation repair (n=6), and atrial septostomy (n=3) followed by ASO at a later age. In our later experience (group 2, n=16), single-stage total repair was performed; ASO with ventricular septal defect closure and baffling of left ventricle to neo-aorta performed in neonates with arch obstruction (n=8), or at age 6 weeks in those with no arch obstruction (n=8). Concomitant relief of right-ventricle outflow-tract obstruction (RVOTO) was performed in 14 patients. Demographics and operative variables affecting outcomes were analyzed.
  
  
  RESULTS
  Mean age at operation for group 1 and 2 patients was 312+/-477 and 42+/-31 days (p<0.0001). Aortic arch obstruction (52%), sub-aortic RVOTO (61%) and unusual coronary patterns (52%) were similar for both groups. One-year survival for group 1 and 2 patients was 47+/-5% and 100% (p=0.001). Associated anomalies such as great vessels position, arch obstruction, and unusual coronaries were not significant risk factors for mortality on multivariable analysis. Ten-year freedom from RVOT and arch re-operation was 55+/-5% and 96+/-4%. Five-year event-free survival for groups 1 and 2 was 35+/-6% and 87+/-1% (p=0.0016). Significant factors affecting event-free survival were group 1 (HR 108, p=0.0005), and larger weight at surgery (HR 1.3, p=0.02).
  
  
  CONCLUSIONS
  The Taussig-Bing anomaly is complex and often associated with other cardiac anomalies (arch obstruction, RVOTO, unusual coronary pattern). Advances in perioperative care have significantly mitigated mortality. In our experience with single-stage total repair, event-free survival, especially freedom from RVOT re-operation, has significantly improved.
authors: The Labatt Family Heart Centre, Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada. balsoufi@hotmail.com
authors: Bahaaldin
authors: B
authors: Alsoufi
authors: Sally
authors: S
authors: Cai
authors: William G
authors: WG
authors: Williams
authors: John G
authors: JG
authors: Coles
authors: Christopher A
authors: CA
authors: Caldarone
authors: Andrew M
authors: AM
authors: Redington
authors: Glen S
authors: GS
authors: Van Arsdell
mesh_terms: D001015:Aortic Arch Syndromes / Q000601:surgery; D001835:Body Weight; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D002315:Cardiopulmonary Bypass / Q000379:methods; D003330:Coronary Vessel Anomalies / Q000601:surgery; D004310:Double Outlet Right Ventricle / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010477:Perfusion / Q000379:methods; D012086:Reoperation; D016019:Survival Analysis; D016896:Treatment Outcome; D014694:Ventricular Outflow Obstruction / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery