title: Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6.
abstract: The joggle mouse is a recessive ataxic mutant carrying an unknown mutation in a C3H/He (C3H)-derived chromosomal segment. Taking advantage of the mouse genome database, we selected 127 DNA microsatellite markers showing heterozygosity between C3H and C57BL/6J (B6) and a first round of screening for the joggle mutation was performed on B6-jog/+ partial congenic mice (N4). We identified 4 chromosomal regions in which 13 microsatellite markers show heterozygosity between C3H and B6. Then, we analyzed the genotype of these 4 chromosomal regions in mice that showed the joggle phenotype and mapped the jog locus between markers D6Mit104 (111.4 Mb) and D6Mit336 (125.1 Mb) (an interval of 13.7 Mb) on chromosome 6. By using a partial congenic strain together with the mouse genome database, we successfully mapped the chromosomal localization of the jog locus much more efficiently than by conventional linkage analysis.
authors: Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Japan.
authors: Xiao-yang
authors: XY
authors: Sun
authors: Zi-yan
authors: ZY
authors: Chen
authors: Yasuhiko
authors: Y
authors: Kanou
authors: Yoshiko
authors: Y
authors: Takagishi
authors: Yoshitaka
authors: Y
authors: Hayashi
authors: Tamio
authors: T
authors: Ohno
authors: Yoshiharu
authors: Y
authors: Murata
authors: Sen-ichi
authors: S
authors: Oda
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D006579:Heterozygote; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics*; D018895:Microsatellite Repeats