title: Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.
abstract: BACKGROUND
  There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans.
  
  
  OBJECTIVE
  This study was designed to assess the effect of short-and long-term O(3) exposures on biomarkers of oxidative stress in healthy individuals.
  
  
  METHODS
  Biomarkers of lipid peroxidation, 8-isoprostane (8-iso-PGF), and antioxidant capacity ferric reducing ability of plasma (FRAP) were analyzed in two groups of healthy college students with broad ranges of ambient O3 exposure during their lifetimes and previous summer recess either in Los Angeles (LA, n = 59) or the San Francisco Bay Area (SF, n = 61).
  
  
  RESULTS
  Estimated 2-week, 1-month, and lifetime O3 exposures were significantly correlated with elevated 8-iso-PGF. Elevated summertime exposures resulted in the LA group having higher levels of 8-iso-PGF than the SF group (p = 0.02). Within each location, males and females had similar 8-iso-PGF. No regional difference in FRAP was observed, with significantly higher FRAP in males in both groups (SF: p = 0.002; LA: p = 0.004). An exposure chamber substudy (n = 15) also showed a significant increase in 8-iso-PGF as well as an inhibition of FRAP immediately after a 4-hr exposure to 200 ppb O3, with near normalization by 18 hr in both biomarkers.
  
  
  CONCLUSIONS
  Long-term exposure to O3 is associated with elevated 8-iso-PGF, which suggests that 8-iso-PGF is a good biomarker of oxidative damage related to air pollution.
authors: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
authors: Connie
authors: C
authors: Chen
authors: Mehrdad
authors: M
authors: Arjomandi
authors: John
authors: J
authors: Balmes
authors: Ira
authors: I
authors: Tager
authors: Nina
authors: N
authors: Holland
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D004781:Environmental Exposure; D005260:Female; D006262:Health; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010126:Ozone / Q000506:poisoning*; D012727:Sex Characteristics; D013334:Students
chemical_list: C492917:8-isoprostaglandin F1alpha; D000975:Antioxidants; D015415:Biomarkers; D028421:Isoprostanes; D010126:Ozone