Diacylglycerol oil for the metabolic syndrome.
Excess adiposity has been shown to play a crucial role in the development of the metabolic syndrome. The elevated fasting and postprandial triglyceride-rich lipoprotein levels is the central lipid abnormality observed in the metabolic syndrome. Recent studies have indicated that diacylglycerol (DAG) is effective for fasting and postprandial hyperlipidemia and preventing excess adiposity by increasing postprandial energy expenditure. We will here discuss the mechanisms of DAG-mediated improvements in hyperlipidemia and in postprandial energy expenditure, and effects of DAG oil on lipid/glucose metabolism and on body fat. Further, the therapeutic application of DAG for the metabolic syndrome will be considered.
Yanai
Hidekatsu
H
Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp
Tomono
Yoshiharu
Y
Ito
Kumie
K
Furutani
Nobuyuki
N
Yoshida
Hiroshi
H
Tada
Norio
N
D050154:Adiposity / Q000187:drug effects* / Q000502:physiology; D004075:Diglycerides / Q000627:therapeutic use*; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000517:prevention & control; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000517:prevention & control; D009765:Obesity / Q000517:prevention & control; D019518:Postprandial Period
D004075:Diglycerides