title: Clinical evaluation of sodium hyaluronate in the treatment of patients with sopraspinatus tendinosis under echographic guide: experimental study of periarticular injections.
abstract: OBJECTIVE
  The purpose of this study was to examine the effect of periarticular injection of hyaluronate into shoulders with supraspinatus tendinosis under echographic guide.
  
  
  METHODS
  The subjects were 56 patients with clinical, echographic and magnetic resonance diagnosis of supraspinatus tendinosis. They were divided in two groups by random sampling; 28 patients were assigned in SH group (sodium hyaluronate) and 28 patients in SC group (sodium chloride). The test drug was 20mg sodium hyaluronate (2ml, Hyalgan, Fidia SpA, Abano T., P.M. 500-700.000, 20mg/2ml).
  
  
  RESULTS
  Preliminary results showed that sodium hyaluronate presented the highest efficacy in the improvement of clinical symptoms and recovery of functional status in patients with supraspinatus tendinosis in fact the mean V.A.S. score (Visual Analogue Scale) at 1 month after the end of the infiltrative cycle was 8.0 in the SC group vs. 2.8 in SH group and these numerical data were substantially unchanged also after 3 and 4 months.
  
  
  CONCLUSIONS
  Hyaluronate injection under echographic guide should be use not only as a lubricant but also to prevent articular cartilage degeneration and cover and protect the articular cartilage; indeed sodium hyaluronate can decrease inflammatory joint process.
authors: Istituto di Scienze Radiologiche Università degli Studi di Sassari, Italy. fmeloni@sirm.org
authors: F
authors: F
authors: Meloni
authors: F
authors: F
authors: Milia
authors: M
authors: M
authors: Cavazzuti
authors: C
authors: C
authors: Doria
authors: P
authors: P
authors: Lisai
authors: S
authors: S
authors: Profili
authors: G B
authors: GB
authors: Meloni
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D012785:Shoulder Joint / Q000000981:diagnostic imaging* / Q000187:drug effects; D052256:Tendinopathy / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid