Preparation of fully substituted anilines for the synthesis of functionalized indoles.
A wide range of highly functionalized indoles were prepared by the successive magnesiation of readily available o-alkynyl protected anilines using TMPMgCl.LiCl or LDA, followed by a KH-mediated cyclization reaction.
Stoll
Armin H
AH
Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, Haus F, 81377 Munich, Germany.
Knochel
Paul
P
D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D000480:Alkynes; D000814:Aniline Compounds; D007211:Indoles