Lack of dopaminergic modulation of cognitive flexibility.
OBJECTIVE
To evaluate performance on a cognitive flexibility task after administration of a dopaminergic agonist.


BACKGROUND
L-3,4-dihydroxyphenylalanine, which is converted into dopamine and norepinephrine, results in a restriction of the semantic network in priming experiments. Recent evidence suggests that flexibility of access to semantic networks in problem solving is mediated by the noradrenergic system. We wished to determine if dopaminergic agonists also affect this type of cognitive flexibility.


METHODS
Eighty-four subjects were tested twice on an anagram task, once 1 hour after bromocriptine (dopamine agonist) and once 1 hour after placebo administration.


RESULTS
No difference was detected between placebo and bromocriptine on anagram performance.


CONCLUSIONS
Therefore, modulation of this type of cognitive flexibility does not seem to be mediated by the dopaminergic system. This suggests that the noradrenergic modulation of cognitive flexibility previously reported does not seem to extend to the dopaminergic system among catecholamines.
Smyth
Shawn F
SF
Department of Neurology, The Ohio State University, Columbus, OH 43210, USA.
Beversdorf
David Q
DQ
D000328:Adult; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology; D001971:Bromocriptine / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003405:Creativity; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D011340:Problem Solving / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012660:Semantics
D018491:Dopamine Agonists; D001971:Bromocriptine; D004298:Dopamine