title: Fatal haemophagocytic syndrome and hepatitis associated with visceral leishmaniasis.
abstract: Haemophagocytic syndrome (HPS) secondary to infections occurs due to excessive, non-malignant proliferation of histiocytes, with resultant haemophagocytosis. The syndrome is essentially treatable, provided timely etiological diagnosis is achieved. In this report, we present a rare case of a child who hailed from Uttaranchal and presented with severe hepatitis. Bone marrow examination revealed an unexpected diagnosis of HPS secondary to visceral leishmaniasis. Despite initiating appropriate antileishmanial treatment, the child had a fatal outcome.
authors: Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029, India.
authors: P
authors: P
authors: Mathur
authors: J C
authors: JC
authors: Samantaray
authors: P
authors: P
authors: Samanta
mesh_terms: D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000469:parasitology / Q000473:pathology; D002675:Child, Preschool; D017809:Fatal Outcome; D006505:Hepatitis / Q000469:parasitology*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000188:drug therapy; D051359:Lymphohistiocytosis, Hemophagocytic / Q000469:parasitology*
chemical_list: D000981:Antiprotozoal Agents