title: The effects of inhaled acetone on place conditioning in adolescent rats.
abstract: BACKGROUND
  Acetone is an ubiquitous ingredient in many household products (e.g., glue solvents, air fresheners, adhesives, nail polish, and paint) that is putatively abused; however, there is little empirical evidence to suggest that acetone alone has any abuse liability. Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus.
  
  
  METHODS
  Three groups of male, Sprague-Dawley rats were exposed to acetone concentrations of 5000, 10,000 or 20,000 ppm for 1 h in a conditioned place preference apparatus alternating with air for 6 pairing sessions. A place preference test ensued in an acetone-free environment. To test the preference of acetone as a function of pairings sessions, the 10,000 ppm group received an additional 6 pairings and an additional group received 3 pairings. The control group received air in both compartments. Locomotor activity was recorded by infrared photocells during each pairing session.
  
  
  RESULTS
  We noted a dose response relationship to acetone at levels 5000-20,000 ppm. However, there was no correlation of place preference as a function of pairing sessions at the 10,000 ppm level. Locomotor activity was markedly decreased in animals on acetone-paired days as compared to air-paired days.
  
  
  CONCLUSIONS
  The acetone concentrations we tested for these experiments produced a markedly decreased locomotor activity profile that resemble CNS depressants. Furthermore, a dose response relationship was observed at these pharmacologically active concentrations, however, animals did not exhibit a positive place preference.
authors: Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. dlee@bnl.gov <dlee@bnl.gov>
authors: Dianne E
authors: DE
authors: Lee
authors: Jennifer
authors: J
authors: Pai
authors: Uma
authors: U
authors: Mullapudui
authors: David L
authors: DL
authors: Alexoff
authors: Richard
authors: R
authors: Ferrieri
authors: Stephen L
authors: SL
authors: Dewey
mesh_terms: D000096:Acetone / Q000008:administration & dosage / Q000494:pharmacology*; D000280:Administration, Inhalation; D000818:Animals; D019540:Area Under Curve; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012997:Solvents; D000096:Acetone