title: First synthesis of 4'-selenonucleosides showing unusual Southern conformation.
abstract: The first synthesis of 4'-selenonucleosides was achieved using a Pummerer-type condensation as a key step. All stereoelectronic effects shown in 4'-oxonucleosides were overwhelmed by the size of selenium and steric interactions, driving the conformation to the C2'-endo/ C3'-exo twist (Southern) conformation.
authors: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. lakjeong@ewha.ac.kr
authors: Lak Shin
authors: LS
authors: Jeong
authors: Dilip K
authors: DK
authors: Tosh
authors: Hea Ok
authors: HO
authors: Kim
authors: Ting
authors: T
authors: Wang
authors: Xiyan
authors: X
authors: Hou
authors: Ho Seop
authors: HS
authors: Yun
authors: Youngjoo
authors: Y
authors: Kwon
authors: Sang Kook
authors: SK
authors: Lee
authors: Jungwon
authors: J
authors: Choi
authors: Long Xuan
authors: LX
authors: Zhao
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009705:Nucleosides; D016566:Organoselenium Compounds