title: Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.
abstract: As cells undergo oncogenic transformation and as malignant cells arrive at metastatic sites, a complex interplay occurs with the surrounding stroma. This dialogue between the tumor and stroma ultimately dictates the success of the tumor cells in the given microenvironment. As a result, understanding the molecular mechanisms at work is important for developing new therapeutic modalities. Proteases are major players in the interaction between tumor and stroma. This review will focus on the role of proteases in modulating tumor-stromal interactions of both primary breast and prostate tumors as well as at bone metastatic sites in a way that favors tumor growth.
authors: Department of Pathology and Microbiology, The University of Nebraska Medical Center, Omaha, NE 68198-5845, USA.
authors: Thomas J
authors: TJ
authors: Wilson
authors: Rakesh K
authors: RK
authors: Singh
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D002403:Cathepsins / Q000502:physiology; D002450:Cell Communication; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases / Q000502:physiology; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D010447:Peptide Hydrolases / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism
chemical_list: D002403:Cathepsins; D010447:Peptide Hydrolases; D020782:Matrix Metalloproteinases