Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
Miyake
Kazuaki
K
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Horikawa
Yukio
Y
Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.|Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Hara
Kazuo
K
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yasuda
Kazuki
K
Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo, Japan.
Osawa
Haruhiko
H
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
Furuta
Hiroto
H
The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Hirota
Yushi
Y
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yamagata
Kazuya
K
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hinokio
Yoshinori
Y
Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan.
Oka
Yoshitomo
Y
Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan.
Iwasaki
Naoko
N
Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
Iwamoto
Yasuhiko
Y
Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
Yamada
Yuichiro
Y
Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.|Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan.
Seino
Yutaka
Y
Kansai Electric Power Hospital, Osaka, Japan.|Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan.
Maegawa
Hiroshi
H
Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Kashiwagi
Atsunori
A
Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Yamamoto
Ken
K
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Tokunaga
Katsushi
K
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Takeda
Jun
J
Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.
Makino
Hideichi
H
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
Nanjo
Kishio
K
The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Kadowaki
Takashi
T
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Kasuga
Masato
M
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. kasuga@med.kobe-u.ac.jp.
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein