[Research advances in animal models of intervertebral disc degeneration].
OBJECTIVE
To review the research advances in animal models of human disc degeneration.


METHODS
The relative articles in recent years were extensively reviewed. Studies both at home and abroad were analyzed and classified. The advantages and disadvantages of each method were compared.


RESULTS
Studies were classified as either experimentally induced models or spontaneous models. The induced models were subdivided as mechanical (alteration of forces on the normal disc), structural (injury or chemical alteration) and genetically induced models. Spontaneous models included those animals that naturally developed degenerative disc disease.


CONCLUSIONS
Animal model of intervertebral disc degeneration is an important path for revealing the pathogenesis of human disc degeneration, and play an important role in testing novel interventions. With recent advances in the relevance of animal models and humans, it has a great prospect in study of human disc degeneration.
Zhang
Wenli
W
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China. zwlbox@163.com
Liu
Hao
H
Li
Tanzhu
T
D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D007403:Intervertebral Disc / Q000293:injuries / Q000473:pathology* / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D011817:Rabbits; D013314:Stress, Mechanical