Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes.
Accumulating evidence indicates that gene order in eukaryotic genomes is not completely random and that genes with similar expression levels tend to be clustered within the same genomic neighborhoods. The mechanism behind these gene coexpression clusters is as yet unclear. In this article, plausible biochemical, genetic, evolutionary, and technological determinants of this pattern are briefly reviewed.
Michalak
Pawel
P
Department of Biology, University of Texas Arlington, P.O. Box 19498, Arlington, TX 76019, USA. michalak@uta.edu
D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D005057:Eukaryotic Cells; D019143:Evolution, Molecular; D015870:Gene Expression; D005786:Gene Expression Regulation; D023061:Gene Order; D016678:Genome; D006801:Humans; D005810:Multigene Family; D009876:Operon; D012441:Saccharomyces cerevisiae / Q000235:genetics