title: A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target.
abstract: A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.
authors: Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
authors: Aya
authors: A
authors: Wakata
authors: Sean M
authors: SM
authors: Cahill
authors: Michael
authors: M
authors: Blumenstein
authors: Rosalind H
authors: RH
authors: Gunby
authors: Steffen
authors: S
authors: Jockusch
authors: Angel A
authors: AA
authors: Marti
authors: Barbara
authors: B
authors: Cimbro
authors: Carlo
authors: C
authors: Gambacorti-Passerini
authors: Arianna
authors: A
authors: Donella-Deana
authors: Lorenzo A
authors: LA
authors: Pinna
authors: Nicholas J
authors: NJ
authors: Turro
authors: David S
authors: DS
authors: Lawrence
mesh_terms: D000595:Amino Acid Sequence; D000077548:Anaplastic Lymphoma Kinase; D000970:Antineoplastic Agents / Q000737:chemistry; D005456:Fluorescent Dyes; D015394:Molecular Structure; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D014443:Tyrosine; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases