Strain and age affect electroconvulsive seizure testing in rats.
Electroconvulsive seizure thresholds were compared between adolescent and mature Sprague--Dawley, Wistar, and Fischer rats. All strains had similar hindbrain or forebrain seizure thresholds as adolescents. As adults, hindbrain or forebrain seizure thresholds were highest for Sprague--Dawley and lowest for Fischer rats. Conversely, limbic seizure thresholds during adolescence were highest for Fischer rats. Additional study is needed to better delineate strain and maturational effects on electroconvulsive seizure testing.
Statler
Kimberly D
KD
Department of Pediatrics, Division of Pediatric Critical Care, University of Utah, PO Box 581289, 295 Chipeta Way, Salt Lake City, UT 84158, United States. kim.statler@hsc.utah.edu
Swank
Seth
S
White
H Steve
HS
D000375:Aging / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D004597:Electroshock; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D008297:Male; D011595:Psychomotor Agitation / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics* / Q000503:physiopathology*; D013045:Species Specificity