title: Endometrial expression of vasopressin, oxytocin and their receptors in patients with primary dysmenorrhoea and healthy volunteers at ovulation.
abstract: OBJECTIVE
  To investigate gene expressions for neurohypophyseal and ovarian hormones as well as their receptors in the endometrium of women with primary dysmenorrhoea and healthy subjects at ovulation.
  
  
  METHODS
  A group of eight women with moderate to severe dysmenorrhoea and eight healthy subjects were compared in parallel between 18 and 35 years of age, regularly menstruating, non-overweight and nulliparous. The study was performed at The Department of Obstetrics and Gynecology, University Hospital of Lund, Sweden. Endometrial biopsies were taken around the time of ovulation, which was determined by repeated ultrasound examinations. Receptor and gene expressions for oxytocin and vasopressin in the tissue were measured.
  
  
  RESULTS
  The gene expression for oxytocin receptor was significantly lower in dysmenorrhoic than in healthy women, in median 1.21 and 3.44 oxytocin-receptor/actin, respectively (p=0.048). The expressions for oxytocin peptide, vasopressin V1a receptor, oestrogen receptor alpha, beta and progesterone receptor did not differ between the two groups. Expression of vasopressin peptide was not detectable.
  
  
  CONCLUSIONS
  A lower oxytocin receptor gene expression at mid-cycle could be involved in the aetiology of primary dysmenorrhoea. However, the importance of a paracrine effect of oxytocin and its receptor at ovulation warrants further investigation.
authors: Department of Obstetrics and Gynecology, University of Lund, University Hospital, SE-221 85 Lund, Sweden.
authors: Ragner
authors: R
authors: Liedman
authors: Stefan R
authors: SR
authors: Hansson
authors: David
authors: D
authors: Howe
authors: Sarah
authors: S
authors: Igidbashian
authors: Rachel J
authors: RJ
authors: Russell
authors: Mats
authors: M
authors: Akerlund
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D004412:Dysmenorrhea / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000378:metabolism; D010060:Ovulation / Q000378:metabolism*; D010121:Oxytocin / Q000378:metabolism*; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen; D018045:Receptors, Oxytocin; D011980:Receptors, Progesterone; D017483:Receptors, Vasopressin; D014667:Vasopressins; D010121:Oxytocin