title: Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group.
abstract: Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin-dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the -786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the 'ab' genotype of the 27-bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.
authors: Laboratoire de Biologie, Unité d'Immunologie, CHU Beni-Messous, Algiers, Algeria.
authors: R
authors: R
authors: Djidjik
authors: M
authors: M
authors: Ghaffor
authors: M
authors: M
authors: Brun
authors: M
authors: M
authors: Gharnaout
authors: S S
authors: SS
authors: Salah
authors: W
authors: W
authors: Boukouaci
authors: H
authors: H
authors: Djidjik
authors: A
authors: A
authors: Benyounes
authors: K
authors: K
authors: Koumaravelou
authors: R
authors: R
authors: Krishnamoorthy
authors: M C
authors: MC
authors: Abbadi
authors: D
authors: D
authors: Charron
authors: R
authors: R
authors: Tamouza
mesh_terms: D000293:Adolescent; D000328:Adult; D000462:Algeria; D000818:Animals; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052248:Nitric Oxide Synthase Type I / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D012130:Respiratory Hypersensitivity / Q000235:genetics*
chemical_list: C496314:NOS3 protein, human; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III