Cell-penetrating peptides for drug delivery across membrane barriers.
During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.
Foged
Camilla
C
Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Faculty of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen O, Denmark. cfo@farma.ku.dk
Nielsen
Hanne Moerck
HM
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004337:Drug Carriers / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D010455:Peptides / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations