Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection.
Thai patients enrolled in STACCATO with HIV/hepatitis B virus (HBV) co-infection and tenofovir/emtricitabine-based antiretroviral therapy (ART) were randomly assigned to continuous treatment or CD4 cell count-guided interruptions. HBV replication was suppressed below detection in 15/16 patients. Structured treatment interruption increased transaminases and HBV viraemia in five of six patients; one flare was severe. Conversion to anti-hepatitis Be occurred with continuous treatment only. Tenofovir/emtricitabine-containing ART is highly effective in controlling chronic HIV/HBV co-infection but treatment should not be interrupted.
Nüesch
Reto
R
HIV-NAT, The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Ananworanich
Jintanat
J
Srasuebkul
Preeyaporn
P
Chetchotisakd
Ploenchan
P
Prasithsirikul
Wisit
W
Klinbuayam
Wirat
W
Mahanontharit
Apicha
A
Jupimai
Thidarat
T
Ruxrungtham
Kiat
K
Hirschel
Bernard
B
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000008:administration & dosage*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D000068679:Emtricitabine; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage*; D000068698:Tenofovir; D013785:Thailand; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome; D019562:Viral Load
D044966:Anti-Retroviral Agents; D000998:Antiviral Agents; D006513:Hepatitis B e Antigens; D063065:Organophosphonates; D003841:Deoxycytidine; D000068698:Tenofovir; D000637:Transaminases; D000068679:Emtricitabine; D000225:Adenine