title: Lupin sensitization and clinical allergy in food allergic children in Norway.
abstract: OBJECTIVE
  The aim of the present pilot study was to investigate to what extent children in Norway sensitized to lupin had clinical lupin allergy, and to compare sensitization to lupin with sensitization to other legumes.
  
  
  METHODS
  Thirty-five children with food allergy referred to a national referral hospital were evaluated with skin prick test (SPT) and analysis of serum-specific IgE to lupin, peanut, pea and soy. The children with positive SPTs to lupin were offered oral food challenges with lupin flour.
  
  
  RESULTS
  Fifteen children (43%) had positive SPT and 17 children (49%) had serum-specific IgE to lupin. Ten SPT-positive children underwent oral food challenges and one experienced an allergic reaction to lupin flour. This child was one of six challenged children with IgE antibodies to peanut >15 kU(A)/L. There was a strong relationship between positive SPT to lupin flour and positive SPT to soy and between positive SPT to lupin and specific IgE to soy, pea and peanut.
  
  
  CONCLUSIONS
  Children with sensitization to lupin are not likely to have a clinical lupin allergy. Avoidance of lupin on the basis of lupin sensitization or peanut allergy would lead to unnecessarily strict diets. Food challenge is currently necessary to diagnose lupin allergy.
authors: Voksentoppen, Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway. helene.lindvik@rikshospitalet.no
authors: Helene
authors: H
authors: Lindvik
authors: Lise
authors: L
authors: Holden
authors: Martinus
authors: M
authors: Løvik
authors: Milada
authors: M
authors: Cvancarova
authors: Ragnhild
authors: R
authors: Halvorsen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D031297:Lupinus / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D009664:Norway; D010865:Pilot Projects; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E