Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study.
Serotonergic dysfunction appears to be involved in the pathogenesis of schizophrenia. The loudness dependence of auditory evoked potentials (LDAEP) has been suggested to be a valid indicator of the brain serotonin system's activity in humans. Patients with schizophrenia showed weaker LDAEP, indicating high serotonergic activity, in comparison to healthy controls. Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia.
Juckel
Georg
G
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany. george.juckel@wkp-lwl.org
Gudlowski
Yehonala
Y
Müller
Dirk
D
Ozgürdal
Seza
S
Brüne
Martin
M
Gallinat
Jürgen
J
Frodl
Thomas
T
Witthaus
Henning
H
Uhl
Idun
I
Wutzler
Alexander
A
Pogarell
Oliver
O
Mulert
Christoph
C
Hegerl
Ulrich
U
Meisenzahl
Eva-Maria
EM
D000328:Adult; D010054:Brief Psychiatric Rating Scale; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008144:Loudness Perception / Q000502:physiology*; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000502:physiology*; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000502:physiology
D012701:Serotonin