The retrotrapezoid nucleus and central chemoreception.
Central respiratory chemoreception (CRC) is the mechanism by which brain pCO2 regulates breathing. The molecular and cellular basis of CRC is still poorly understood. In this review, we describe the properties of a cluster of pH-responsive neurons located in the retrotrapezoid region of the medulla oblongata and analyze whether these cells qualify as central respiratory chemoreceptors.
Guyenet
Patrice G
PG
University of Virginia, Department of Pharmacology, USA. pgg@virginia.edu
Bayliss
Douglas A
DA
Mulkey
Daniel K
DK
Stornetta
Ruth L
RL
Moreira
Thiago S
TS
Takakura
Ana T
AT
D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology; D002628:Chemoreceptor Cells / Q000502:physiology*; D045853:Exhalation / Q000502:physiology; D008526:Medulla Oblongata / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D012143:Respiratory Physiological Phenomena; D014628:Vagotomy
D002245:Carbon Dioxide