title: Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan.
abstract: The objective of this study was to investigate the association of human T-lymphotropic virus-type I (HTLV-I) infection with sporadic inclusion body myositis in 11 patients from an endemic area in Japan. The clinical features were consistent with sporadic inclusion body myositis, and anti-HTLV-I antibodies were present in the sera of all patients. Their muscle biopsies showed the diagnostic features of inclusion body myositis, including endomysial T-cell infiltration, rimmed vacuoles, deposits of phosphorylated tau, and abnormal filaments in the nuclei and cytoplasm of the myofibers. The fibers expressed major histocompatibility complex class I antigens and were invaded by CD8 and CD4 cells. In a single human leukocyte antigen-A2-positive patient, in situ human leukocyte antigen-A*0201 / Tax11-19-pentamer staining showed pentamer-positive cells surrounding the muscle fibers. Double-immunogold silver staining and polymerase chain reaction in situ hybridization revealed that HTLV-I proviral DNA was localized on helper-inducer T cells, but not on muscle fibers. Human T-lymphotropic virus-type I proviral loads in peripheral blood mononuclear cells from each patient were similar to those in HTLV-I-associated myelopathy/tropical spastic paraparesis. This study suggests that HTLV-I infection may be one of the causes of sporadic inclusion body myositis, as has been reported in human immunodeficiency virus type-1 infection.
authors: Department of Neurology and Geriatrics, Center for Chronic Viral Diseases, Graduate School of Kagoshima University, Kagoshima, Japan.
authors: Eiji
authors: E
authors: Matsuura
authors: Fujio
authors: F
authors: Umehara
authors: Hirohisa
authors: H
authors: Nose
authors: Itsuro
authors: I
authors: Higuchi
authors: Eiji
authors: E
authors: Matsuoka
authors: Koutarou
authors: K
authors: Izumi
authors: Ryuji
authors: R
authors: Kubota
authors: Mineki
authors: M
authors: Saito
authors: Shuji
authors: S
authors: Izumo
authors: Kimiyoshi
authors: K
authors: Arimura
authors: Mitsuhiro
authors: M
authors: Osame
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D016356:Gene Products, tax / Q000378:metabolism; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D007564:Japan / Q000453:epidemiology; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D018979:Myositis, Inclusion Body / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D016622:Silver Staining / Q000379:methods
chemical_list: D016356:Gene Products, tax; C514970:tax protein, Human T-lymphotrophic virus 1