title: Loss of the extra chromosome 21 in a patient with Down syndrome and myelodysplasia.
abstract: Monosomy 21 is a rare acquired karyotypic abnormality associated with myeloid disorders. Occurrence of loss of one chromosome 21 in the background of trisomy 21 in Down syndrome, resulting in the pseudo-normalization of trisomy 21, is a novel finding. The case is described of a patient with Down syndrome who acquired such a genetic abnormality as a result of myelodysplastic syndrome.
authors: Department of Hematology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore. daryl.tan@sgh.com.com.sg
authors: Daryl
authors: D
authors: Tan
authors: Lai Ching
authors: LC
authors: Lau
authors: Li Min
authors: LM
authors: Teng
authors: Swati
authors: S
authors: Sane
authors: Tse Hui
authors: TH
authors: Lim
authors: Sim Leng
authors: SL
authors: Tien
mesh_terms: D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009030:Mosaicism; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics*; D014314:Trisomy