title: [Preparation and examination of the vitro releasing of pH-dependent kuijiekang tablet for colon-specific delivery].
abstract: OBJECTIVE
  To prepare the pH-dependent kuijiekang tablet for colon-specific delivery used in treating the ulcerative colitis and to develop the in vitro release method of kuijiekang tablets.
  
  
  METHODS
  The coating prescription was screened by the in vitro delivery of Puerarin and Berberine hydrochloride. The in-vitro releasing property of the preparation was examined by the method of in-vitro delivery.
  
  
  RESULTS
  The preparation methods of the pH-dependent kuijiekang tablet for colon-specific delivery was obtained from the in-vitro delivery, Puerarin and Berberine hydrochloride were not detected in the simulated gastric fluid after 2 h and the quantitied of Puerarin and Berberine hydrochlo4de were less 10% in the simulated intestinal fluid after 4 h. The quantities of Puerarin and Berberine hydrochloride were 90.07% and 89.87%.
  
  
  CONCLUSIONS
  It can be prepared and the preparation is a promising delivery system for drugs to be delivery to the colon.
authors: The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors: Rui-zhen
authors: RZ
authors: Li
authors: Hua-wei
authors: HW
authors: Liao
authors: Fei-yuan
authors: FY
authors: Chen
mesh_terms: D001599:Berberine / Q000737:chemistry; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007529:Isoflavones / Q000737:chemistry; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D013608:Tablets, Enteric-Coated; C530198:kuijiekang; D001599:Berberine