title: Role of magnesium sulfate in postoperative pain management for patients undergoing thoracotomy.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of magnesium sulfate on pain management for post-thoracotomy patients.
  
  
  METHODS
  A prospective, randomized, controlled clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Twenty-four patients undergoing thoracotomy.
  
  
  METHODS
  After thoracotomy operations, patients were assigned to 2 groups. The control group received intravenous morphine (0.5 mg/h infusion, 0.3 mg patient-controlled anesthesia dose, 15-minute lockout time) via patient-controlled analgesia, and the magnesium group received magnesium sulfate (30-mg/kg bolus, 10 mg/kg/h infusion for 48 hours) plus the same patient-controlled analgesia protocol.
  
  
  RESULTS
  Visual analog scale for pain score, sedation score, mean arterial pressure, heart rate, and valid and invalid analgesic demand were recorded. Serum magnesium levels were determined at postanesthesia care unit admission, at 24 hours, and at 48 hours. Side effects were also recorded. There were no significant differences between groups with respect to demographics, sedation score, and pain score. Cumulative mean morphine consumption was found to be higher in the control group compared with the magnesium group at 4, 8, and 48 hours (5.6 +/- 1 mg v 3.2 +/- 0.6 mg [p < 0.0001], 10.2 +/- 1.8 mg v 7.2 +/- 1.6 mg [p = 0.0003), and 40.2 +/- 4.5 mg v 34.8 +/- 6.3 mg [p = 0.02], respectively).
  
  
  CONCLUSIONS
  Postoperative use of magnesium sulfate reduced opioid consumption for pain after thoracotomy operations.
authors: Department of Anesthesiology and Intensive Care, Istanbul University, Istanbul, Turkey. pergin@istanbul.edu.tr <pergin@istanbul.edu.tr>
authors: Perihan Ergin
authors: PE
authors: Ozcan
authors: Simru
authors: S
authors: Tugrul
authors: N Mert
authors: NM
authors: Senturk
authors: Elvan
authors: E
authors: Uludag
authors: Nahit
authors: N
authors: Cakar
authors: Lutfi
authors: L
authors: Telci
authors: Figen
authors: F
authors: Esen
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D000700:Analgesics / Q000097:blood / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D013908:Thoracotomy / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D008278:Magnesium Sulfate; D009020:Morphine