Osteomyelitis and the role of biofilms in chronic infection.
Understanding the mechanisms implicated in the initial attachment, development, and maturation of a biofilm phenotype are of tremendous importance for their effect on the medical, industrial, and public health arenas. This review explores the current understanding of the nature of biofilms and the impact that molecular interactions between the bacteria themselves, as well as between bacteria and the host, may have on biofilm development and phenotype using the nonmotile Gram-positive coccus, Staphylococcus aureus, as an example.
Brady
Rebecca A
RA
Department of Microbiology and Immunology, University of Maryland-Baltimore, School of Medicine, Baltimore, MD 21201, USA.
Leid
Jeff G
JG
Calhoun
Jason H
JH
Costerton
J William
JW
Shirtliff
Mark E
ME
D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D006801:Humans; D010019:Osteomyelitis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*