Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry.
This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.
Clapham
Bruce
B
High-Throughput Organic Synthesis and Automation Engineering, Department of Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. bruce.clapham@abbott.com
Wilson
Noel S
NS
Michmerhuizen
Melissa J
MJ
Blanchard
David P
DP
Dingle
David M
DM
Nemcek
Thomas A
TA
Pan
Jeffrey Y
JY
Sauer
Daryl R
DR
D002384:Catalysis; D002625:Chemistry, Organic / Q000295:instrumentation* / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods; D015195:Drug Design; D004867:Equipment Design; D006865:Hydrogenation; D015203:Reproducibility of Results; D012371:Robotics; D054852:Small Molecule Libraries / Q000737:chemistry
D054852:Small Molecule Libraries