In vitro antimycobacterial activities of capuramycin analogues.
Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 microg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.
Reddy
Venkata M
VM
Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. venkatareddy@sequella.com
Einck
Leo
L
Nacy
Carol A
CA
D000617:Aminoglycosides / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000145:classification* / Q000187:drug effects*; D015269:Mycobacterium avium Complex / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology
D000617:Aminoglycosides; D000995:Antitubercular Agents; D009705:Nucleosides; C049983:capuramycin