title: [New insight into pathogenesis of idiopathic myelofibrosis--review].
abstract: Idiopathic myelofibrosis is a type of chronic myeloproliferative disorders characterized by splenomegaly, a leukoerythroblastic blood picture, teardrop poikilocytosis, in various degrees of bone marrow fibrosis and extramedullary hematopoiesis. In this paper, the biological characters and pathogenesis of idiopathic myelofibrosis such as mutation of tyrosine kinase receptor, mutation of GABA transporter 1, JAK2 mutation and c-MPl mutation, as well as other pathogenesis related with idiopathic myelofibrosis were reviewed.
authors: Department Hematology, Nanjing Drum Tower-Hospital, Nanjing University Medical College, Nanjing 210008, China.
authors: Zu-Qiong
authors: ZQ
authors: Xu
authors: Xue-Mei
authors: XM
authors: Sun
mesh_terms: D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D009154:Mutation; D055728:Primary Myelofibrosis / Q000209:etiology* / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D053628:Receptors, Thrombopoietin / Q000235:genetics
chemical_list: D050485:GABA Plasma Membrane Transport Proteins; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D020794:Receptor Protein-Tyrosine Kinases; C507924:JAK2 protein, human; D053614:Janus Kinase 2