Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin.
A large cell neuroendocrine carcinoma (LCNEC) is a rare neoplasm. In this article, we report a case of LCNEC with stromal calcification. A 46-year-old Japanese man was found to have an abnormal shadow in the left upper lobe in a chest X-ray. As the size of the tumor increased during the follow-up, a left upper lobectomy was performed. Histological examination disclosed neuroendocrine morphology consisting of large cells, and subsequent immunohistochemistry confirmed the neuroendocrine differentiation. A diagnosis of LCNEC was established. Additionally, calcification was observed in the stroma within the tumor. Immunohistochemically, parts of neoplastic cells of LCNEC and calcified foci were positive for osteopontin. Finally, we suggest that osteopontin as well as dystrophy within the tumor may be involved in the stromal calcification of LCNEC.
Kuroda
Naoto
N
Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi City, Kochi, Japan. nkurodakrch@yahoo.co.jp
Hamaguchi
Nobumasa
N
Ohara
Masahiko
M
Hirouchi
Takashi
T
Mizuno
Keiko
K
Lee
Gang-Hong
GH
D002114:Calcinosis / Q000473:pathology*; D018287:Carcinoma, Large Cell / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000378:metabolism*
D053495:Osteopontin