title: Synthesis and anti-HCV activity Of 2''-beta-hydroxymethylated nucleosides.
abstract: Synthesis of 2' -beta-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2' -beta-hydroxymethyl group has the appropriate electronic properties interfering with HCV polymerase.
authors: College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
authors: Lak Shin
authors: LS
authors: Jeong
authors: Byul Nae
authors: BN
authors: Yoo
authors: Hea Ok
authors: HO
authors: Kim
authors: Kang Man
authors: KM
authors: Lee
authors: Hyung Ryong
authors: HR
authors: Moon
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011687:Purines; C079308:6-chloropurine