[Clinical and laboratory investigation of hematological malignancy patients carrying 3q21q26 rearrangement].
OBJECTIVE
To investigate the clinical and laboratory characteristics of various hematopoietic malignant patients with t(3;3)(q21;q26) or inv(3) (q21q26).


METHODS
Bone marrow samples were collected at presentation, prepared by short-time unstimulated culture and R-binding, and karyotyped by conventional cytogenetical assay (CCA); megalokaryocytes were detected by Streptavidin-AKP (SAP); immunotype of the leukemia cells was tested by flow cytometric anylysis of surface antigens (FACS).


RESULTS
All of the 9 hematopoietic malignant patients with t(3;3)(q21;q26) or inv(3) (q21q26) manifested myelodysplasia and poor treatment response. One of them relapsed shortly after allogenic hemotopoietic stem cell transplantation (allo-HSCT).


CONCLUSIONS
Patients with 3q21q26 rearrangement can be found in various hematopoietic malignances and demonstrate an unique entity. These patients show poor treatment response and have extremely poor prognosis.
Xu
Fang-yun
FY
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 PR China.
Liu
Xu-ping
XP
Qin
Shuang
S
Li
Cheng-wen
CW
Lin
Dong
D
Mi
Ying-chang
YC
Liu
Shi-he
SH
Wang
Jian-xiang
JX
D000328:Adult; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic