title: [Kinetics study on intestinal absorption of bergenin in rats].
abstract: OBJECTIVE
  To study the kinetics of intestine absorption of bergenin in rats.
  
  
  METHODS
  The intestine absorption of bergenin in the rats was determined by in situ perfusion. The HPLC were used to determine the concentration of bergenin in the perfusate and the plasma. The concentrations of bergenin in various sites of the intestine and the pH values were studied.
  
  
  RESULTS
  In the range of 0. 07-0. 21 mg/mL, the absorption of bergenin exhibited linear kinetics. The absorption varied in the duodenum, jejunum, ileum and colon. In the range of pH 5.40-7.80, with the increasing of pH value, the Ka of bergenin decreased.
  
  
  CONCLUSIONS
  Bergenin is absorbed by the entire intestine, but with limited amount. The absorption of the drug is a first-order process with the passive diffusion mechanism.
authors: Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors: Xuan
authors: X
authors: Qin
authors: Dan
authors: D
authors: Zhou
authors: Yuan
authors: Y
authors: Huang
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D051381:Rats
chemical_list: D001578:Benzopyrans; C006741:bergenin