title: Radiotherapy for squamous cell carcinoma of the nasal vestibule.
abstract: OBJECTIVE
  To evaluate the efficacy of radiotherapy (RT) alone or combined with surgery for the treatment of the nasal vestibule squamous cell carcinomas.
  
  
  METHODS
  Seventy-one patients with squamous cell carcinoma of the nasal vestibule were treated with definitive RT at the University of Florida, and 8 patients with advanced T4 cancers were treated with combined surgery and RT. Patients were followed from 4 months to 27.7 years (mean 9.0 years, median 7.9 years). Follow-up on living patients ranged from 6 months to 27.7 years (mean 10.0 years, median 8.1 years).
  
  
  RESULTS
  The 5-year outcomes were: local control, 87%; local-regional control, 77%; freedom from distant metastases, 94%; cause-specific survival, 90%; and survival, 76%. The 5-year local control rates for patients treated with definitive RT were: T1-T2, 95%; T4, 71%; and overall, 86% (P = 0.0046). Local control was achieved in 8 of 8 patients treated with surgery and RT.
  
  
  CONCLUSIONS
  RT results in a high cure rate for T1-T2 and favorable T4 tumors. Surgery and RT result in an improved likelihood of cure for patients with extensive T4.
authors: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
authors: Audrey
authors: A
authors: Wallace
authors: Christopher G
authors: CG
authors: Morris
authors: Jessica
authors: J
authors: Kirwan
authors: Robert J
authors: RJ
authors: Amdur
authors: John W
authors: JW
authors: Werning
authors: William M
authors: WM
authors: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome