title: The effect of platelet-altering medications on bleeding from minor oral surgery procedures.
abstract: OBJECTIVE
  This study was performed to assess the extent of bleeding from minor oral surgical procedures in patients taking platelet-altering medications. They were compared with patients who were not taking platelet-altering medicines to assess differences in extent of blood loss.
  
  
  METHODS
  A prospective observational study design was used to quantitatively assess the amount and severity of bleeding encountered with dentoalveolar surgery in 2 groups. The experimental group consisted of people taking therapeutic doses of platelet-altering medications, and the control group was composed of patients who had not taken a platelet-altering medication for at least 10 days prior to surgery. Surgical blood loss was measured, and the groups were compared for statistically significant differences in blood loss.
  
  
  RESULTS
  There was no difference in blood loss detected between the experimental or control groups. No bleeding complications were encountered.
  
  
  CONCLUSIONS
  Our data suggest that patients on aspirin and NSAIDs can safely undergo routine minor outpatient oral surgical procedures without modification of their platelet-altering medication.
authors: Department of Oral Surgery and Hospital Dentistry, Indiana University, Indianapolis, IN, USA.
authors: Corbin G
authors: CG
authors: Partridge
authors: John H
authors: JH
authors: Campbell
authors: Fernando
authors: F
authors: Alvarado
mesh_terms: D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016063:Blood Loss, Surgical; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D016022:Case-Control Studies; D000077144:Clopidogrel; D006801:Humans; D019647:Oral Surgical Procedures / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D019106:Postoperative Hemorrhage / Q000453:epidemiology*; D011446:Prospective Studies; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin