title: Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy.
abstract: Dendritic cell vaccination has been applied to the treatment of a variety of cancers, including malignant astrocytoma. We have treated 13 patients with malignant astrocytoma using dendritic cell vaccination and have shown that this treatment is safe and is likely to be effective in combination with standard adjuvant therapy. Future studies should prospectively incorporate dendritic cell vaccination together with chemotherapy. Ideally, dendritic cell vaccination should be tested in a prospective fashion, in a coordinated trial involving multiple centres.
authors: Department of Neurosurgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. dwalker@brizbrain.com.au
authors: David G
authors: DG
authors: Walker
authors: Richard
authors: R
authors: Laherty
authors: Frank H
authors: FH
authors: Tomlinson
authors: Teong
authors: T
authors: Chuah
authors: Chris
authors: C
authors: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000473:pathology / Q000628:therapy*; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D016827:CD8 Antigens / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D016827:CD8 Antigens; D019496:Cancer Vaccines; D017493:Leukocyte Common Antigens