The growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family.
The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties.
Reimers
Kerstin
K
Department for Plastic, Hand, Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, D-30659 Hannover, Germany. reimers.kerstin@mh-hannover.de
Choi
Claudia Yu
CY
Bucan
Vesna
V
Vogt
Peter M
PM
D000595:Amino Acid Sequence; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry*; D002417:Cattle; D045744:Cell Line, Tumor; D019295:Computational Biology; D004285:Dogs; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000235:genetics; D010802:Phylogeny; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D051017:Apoptosis Regulatory Proteins; C509178:Ghitm receptor, mouse; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; C490015:Tmbim6 protein, mouse; C523971:lifeguard protein, mouse