title: Expression of BCR-ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia.
abstract: Using a quantitative single nucleotide polymorphism (SNP) assay we have investigated the changes in the expression of the BCR-ABL1 oncogene relative to the wild-type ABL1 and BCR alleles in cells from chronic myeloid leukemia (CML) patients not responding to therapy. The results show a progressive increase in the BCR-ABL1 oncogene expression at the expense of decreased expression of the ABL1 allele, not involved in the fusion. No relative changes in the expression of the two BCR alleles were found. These results demonstrate that allele-specific changes in gene expression, with selective, progressive silencing of the wild-type ABL1 allele in favor of the oncogenic BCR-ABL1 allele occur in CML patients with therapy-resistant disease.
authors: Molecular Medicine, Department of Medical Sciences, Uppsala University, Sweden.
authors: Manu
authors: M
authors: Gupta
authors: Lili
authors: L
authors: Milani
authors: Monica
authors: M
authors: Hermansson
authors: Bengt
authors: B
authors: Simonsson
authors: Berit
authors: B
authors: Markevärn
authors: Ann Christine
authors: AC
authors: Syvänen
authors: Gisela
authors: G
authors: Barbany
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D016313:Genes, abl; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: C513733:ABI1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; D016044:Fusion Proteins, bcr-abl