Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Houghten
Richard A
RA
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA. rhoughten@tpims.org
Pinilla
Clemencia
C
Giulianotti
Marc A
MA
Appel
Jon R
JR
Dooley
Colette T
CT
Nefzi
Adel
A
Ostresh
John M
JM
Yu
Yongping
Y
Maggiora
Gerald M
GM
Medina-Franco
Jose L
JL
Brunner
Daniela
D
Schneider
Jeff
J
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods / Q000706:statistics & numerical data; D045424:Complex Mixtures / Q000737:chemistry*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry*
D045424:Complex Mixtures; D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries