Effects of salicylhydroxamic acid on the proliferation of Atriplex and murine neuroblastoma cells, and on Drosophila egg laying and development.
Salicylhydroxamic acid (SHAM) inhibits the proliferation of cultured plant (Atriplex halimus) and murine neuroblastoma cells with IC50 of 90 and 250 microM, respectively. After 2 h of application, SHAM induces an acceleration of the neuroblastoma cell cycle from G1/S to G2 phases and, after 6 h, it induces an accumulation of the cells in S phase and a cell swelling. Up to 300 microM, SHAM is not cytotoxic and does not induce electrophysiological differentiation of neuroblastoma cells. When Drosophila females are grown in media containing 0.6-1.25 mM SHAM, the rate and number of laid eggs are increased. Furthermore, SHAM stimulates the different development stages from embryo to adult. A general interpretation of the effects of SHAM on cell proliferation and differentiation is proposed.
Dutuit
Pierre
P
Laboratoire d'écotechnologie, université Paris-Sud, 1, allée Cérès, 91440 Bures-sur-Yvette, France. pierre.dutuit@u-psud.fr
Rouzaire-Dubois
Béatrice
B
Talamali
Amel
A
Limbourg-Bouchon
Bernadette
B
Hours
Michel C
MC
Dubois
Jean-Marc
JM
D000818:Animals; D027466:Atriplex / Q000166:cytology* / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004330:Drosophila / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology*; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D010057:Oviducts / Q000166:cytology / Q000187:drug effects; D010058:Oviposition / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology*
D012457:Salicylamides; C005703:salicylhydroxamic acid