title: The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.
abstract: The macroPARPs Parp-9 and Parp-14 are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines. Their genes reside in the same locus (16B3), and the Parp-9 gene lies head-to-head and shares its promoter with the gene encoding its partner, Bbap. Here, we provide a detailed analysis of Parp-9, Parp-14, and Bbap expression during mouse development and adulthood. Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut. In adults, highest expression is maintained in the thymus and intestine. Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. In addition, we show that Bbap is essentially coexpressed with Parp-9 during development and in adult mouse. However, the different levels of their transcripts detected in the developing brain and gut suggest that Bbap and Parp-9 display both common and independent tissue-specific regulations.
authors: Université Strasbourg 1, Institut Gilbert Laustriat, CNRS - UMR 7175, Département Intégrité du Génome, ESBS, Bld Sébastien Brant, BP 10413, Illkirch Cedex, France.
authors: Antoinette
authors: A
authors: Hakmé
authors: Aline
authors: A
authors: Huber
authors: Pascal
authors: P
authors: Dollé
authors: Valérie
authors: V
authors: Schreiber
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D017403:In Situ Hybridization; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000196:embryology / Q000201:enzymology; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D011247:Pregnancy; D013950:Thymus Gland / Q000196:embryology / Q000201:enzymology / Q000378:metabolism
chemical_list: D007527:Isoenzymes; C522628:Parp14 protein, mouse; C529384:Parp9 protein, mouse; D011065:Poly(ADP-ribose) Polymerases