PTPN22: its role in SLE and autoimmunity.
A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.
Chung
Sharon A
SA
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA.
Criswell
Lindsey A
LA
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics* / Q000276:immunology; D013959:Thyroid Diseases / Q000201:enzymology / Q000235:genetics / Q000276:immunology
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22