[Therapeutic effect of p-tyrosol on myocardial electric instability induced by coronary occlusion].
In experiments on rats with left coronary artery occlusion, p-tyrosol (20 mg/kg, intravenously) showed the ability to decrease myocardial electric instability in phase 1b of ventricular arrhythmias: a fraction of rats without arrhythmia was increased by 36%, and the mean value of ventricular arrhythmia index exhibited a 3-fold decrease.
Chernyshov
G A
GA
Plotnikov
M B
MB
Smol'iakova
V I
VI
Krasnov
E A
EA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D054059:Coronary Occlusion / Q000150:complications*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology; D009206:Myocardium; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000209:etiology
D000889:Anti-Arrhythmia Agents; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol