[Influence of FPS on the expression of LDL-R mRNA in the liver tissues of hyperlipidemic rats].
OBJECTIVE
To explore the effect of FPS on low-density lipoprotein acceptor (LDL-R) mRNA in the liver tissues of hyperlipidemic rats.


METHODS
Sixty healthy male SD rats were randomly divided into six groups: normal control, model control, Gynostemma pentaphyllum, FPS low dosage, FPS moderate dosage, and FPS high dosage group. Excepting the rats in the normal control group, the ones in other groups were all made rats' hyperlipidemic model by irrigating hyperlipidemic emulsion into the stomach and observed the expression of LDL-R mRNA in the liver tissues of rats of each group.


RESULTS
Relative content of LDL-RmRNA in low and moderate dosage groups was notably higher than that inmodel group. The contents's difference was not remarkable between FPS moderate dosage group and Gynostemma pentaphyllum group.


CONCLUSIONS
FPS can appreciably increase the expression of LDL-R mRNA in the liver tissues of hyperlipidemic rats and promote the elimination ofLDL-C to reduce serum cholesterol notably.
Wu
Qing-he
QH
College of Traditional Chinese Medicine, Guangzhou University of TCM, Guangzhou 510405, China.
Xing
Yan-hong
YH
Rong
Xiang-lu
XL
Huang
Ping
P
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015870:Gene Expression / Q000187:drug effects; D029774:Gynostemma / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D000459:Phaeophyceae / Q000737:chemistry*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011973:Receptors, LDL / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D012333:RNA, Messenger; D011973:Receptors, LDL; D002784:Cholesterol