[Anticancer drugs used in medicine and being in clinical research].
Tumor diseases are most serious issue of clinical medicine and pharmacology. The coordination compounds of platinum (II) are fundamental group of drugs used in antineoplastic therapy and cisplatin is the first antitumor specimen used in health care. Cisplatin is used in treatment for e.g. ovarian carcinoma, microcellular and no microcellular pulmonary carcinoma, orchiencephaloma, neck and esophagus carcinoma. Carboplatin is the second specimen applied in tumors' therapy. Both the coordination compound of platinum (II) possesses similar antineoplastic action but have a different effectiveness of activity and toxicity. It's very important for contemporary medicine to create new effective cytotoxic compounds of platinum with better clinical tolerance.
Malinowska
Katarzyna
K
Modranka
Roman
R
Kedziora
Józef
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016190:Carboplatin / Q000494:pharmacology / Q000627:therapeutic use; D002945:Cisplatin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin