The prevention of schizophrenia.
Preventive strategies can be divided into universal, selective and indicated prevention and early intervention. Universal interventions are directed to the general population. Selective approaches are targeted at people who have risk factors for an illness, but who do not show any current signs. Indicated approaches target high risk individuals with minimal signs or symptoms foreshadowing mental disorder, but who do not meet diagnostic levels at the current time. Early intervention involves treating those with already diagnosable disorder in a timely and optimal manner aiming to decrease the severity of the illness, and reduce secondary morbidity. Although universal and selective interventions are not yet viable strategies, indicated prevention and early intervention are now realistic possibilities in schizophrenia. Development of methods to identify those at risk of psychosis continues to evolve. Promising results in the prevention and delay of transition to psychotic disorder from high risk state have been found. Early intervention in schizophrenia, including promotion of early help-seeking, has been shown to reduce the duration of untreated psychosis, which is known to be associated with poor outcome in schizophrenia. Early intervention programmes which optimise the care of the first episode have been shown to produce better outcomes than routine management.
Yung
A R
AR
The Department of Psychiatry, The University of Melbourne, Victoria, Australia and ORYGEN Research Centre, Parkville, Victoria, Australia. aryung@unimelb.edu.au
Killackey
E
E
Hetrick
S E
SE
Parker
A G
AG
Schultze-Lutter
F
F
Klosterkoetter
J
J
Purcell
R
R
Mcgorry
P D
PD
D000328:Adult; D002648:Child; D006801:Humans; D013287:Illicit Drugs; D008605:Mental Health Services / Q000458:organization & administration*; D011314:Preventive Health Services / Q000458:organization & administration*; D011618:Psychotic Disorders / Q000453:epidemiology / Q000517:prevention & control; D012559:Schizophrenia / Q000453:epidemiology / Q000517:prevention & control*; D019966:Substance-Related Disorders / Q000453:epidemiology
D013287:Illicit Drugs