Inflammatory marker expression and its implication in Korean ischemic stroke patients.
BACKGROUND
Ischemic stroke is a complex condition influenced by many factors. Previous studies have demonstrated that inflammatory markers might play a role in such vascular diseases. Therefore the purpose of this study was to compare the expression of inflammatory markers in Korean ischemic stroke patients and to investigate their relationship to APOE polymorphism.


METHODS
The patient group consisted of 275 patients with large artery atherosclerosis (LAA, n=169) and small artery occlusion (SAO, n=106). One hundred and nineteen age matched healthy subjects were recruited as the control group. Serum levels of three inflammatory markers (matrix metalloproteinase, MMP-9; tissue inhibitor of metalloproteinase-1, TIMP-1; and high-sensitivity C-reactive protein, hs-CRP) were measured in each patient by using commercially available kits. Comparison of clinical risk factors, inflammatory marker levels, and APOE genotypes between the stroke patient group and control group and between the two patient subgroups was assessed.


RESULTS
Comparison of the stroke group to control group showed significantly elevated levels of circulating MMP-9 (P<0.01) and hs-CRP (P=0.01). Comparison between the individual subgroups revealed a significantly higher level of only TIMP-1 in the LAA subgroup compared to the SAO subgroup (P<0.01). There was no significant difference in inflammatory marker levels among each allele carrier.


CONCLUSIONS
The present study revealed the obvious tendency of increased circulating inflammatory markers in the patients with acute ischemic attack, especially MMP-9 and hs-CRP. Our observations suggest that measurement of serum MMP-9, TIMP-1, and hs-CRP levels may be useful in the diagnosis of ischemic stroke patients.
Park
Su Yon
SY
Department of Laboratory Medicine, Kyunghee Medical Center, Kyunghee University, College of Medicine, Seoul, Korea.
Kim
Meoung Hee
MH
Kang
So Young
SY
Suh
Jin Tae
JT
Lee
Woo In
WI
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000032:analysis; D002340:Carotid Artery Diseases / Q000150:complications; D005260:Female; D005838:Genotype; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007723:Korea; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
D001057:Apolipoproteins E; D015415:Biomarkers; D018836:Inflammation Mediators; D019715:Tissue Inhibitor of Metalloproteinase-1; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9