Intravenous endothelin-1 and ventilatory sensitivity to hypoxia in humans.
The effects of intravenous endothelin-1 (ET-1) on the ventilatory response to hypoxia were studied in healthy humans. Nine volunteers were each exposed twice to 4 hr eucapnic hypoxia. They received a continuous infusion of ET-1 during the ET-1 protocol and an infusion of saline during the control protocol. Plasma ET-1 levels and an index of ventilation were measured regularly. Hypoxia caused a rise in plasma ET-1 in the control protocol. Hypoxia also caused the index of ventilation to increase in both protocols, and this increase was greater in the ET-1 protocol than in the control protocol. These results are consistent with the hypothesis that ET-1 plays a role in controlling the ventilatory response to hypoxia in man.
Talbot
Nick P
NP
University of Oxford, Department of Physiology, Anatomy and Genetics, UK.
Balanos
George M
GM
Robbins
Peter A
PA
Dorrington
Keith L
KL
D000328:Adult; D019332:Endothelin-1 / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007275:Injections, Intravenous; D008297:Male; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*; D013990:Tidal Volume
D019332:Endothelin-1