N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.
The synthesis of two pyrene-functionalized 2'-amino-alpha-L-LNA adenine building blocks is outlined and initial results from thermal denaturation studies are presented.
Andersen
Nicolai K
NK
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark.
Wengel
Jesper
J
Hrdlicka
Patrick J
PJ
D000225:Adenine / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry
C522825:2'-N-(pyren-1-yl)acetyl-2'-amino-alpha-L-LNA; D004277:DNA, Single-Stranded; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D011725:Pyridines; D013938:Thymidine Monophosphate; D012313:RNA; D000225:Adenine