Adiponectin and visfatin concentrations in children treated with valproic acid.
Chronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children. Attempts to determine the underlying pathophysiologic mechanisms have failed. Adipocytokines have recently been defined as a link between glucose and fat metabolism. We herein demonstrate that VPA-associated overweight is accompanied by lower adiponectin and higher leptin concentrations in children. The absence of any relationship with visfatin concentration does not suggest a role of this novel insulin-mimetic hormone in VPA-associated metabolic alterations. Therefore, adiponectin and leptin but not visfatin may be considered as potential regulators of glucose and fat metabolism during VPA-therapy.
Rauchenzauner
Markus
M
Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Austria. markus_rauchenzauner@hotmail.com
Haberlandt
Edda
E
Scholl-Bürgi
Sabine
S
Ernst
Barbara
B
Hoppichler
Fritz
F
Karall
Daniela
D
Ebenbichler
Christoph F
CF
Rostasy
Kevin
K
Luef
Gerhard
G
D052242:Adiponectin / Q000097:blood / Q000502:physiology*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000367:Age Factors; D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood / Q000502:physiology; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000502:physiology*; D014635:Valproic Acid / Q000009:adverse effects* / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D052242:Adiponectin; D000927:Anticonvulsants; D001786:Blood Glucose; D020738:Leptin; D014635:Valproic Acid; D054409:Nicotinamide Phosphoribosyltransferase