Association between SORL1 and Alzheimer's disease in a genome-wide study.
Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3' region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1.
Meng
Yan
Y
Department of Medicine (Genetics Program), Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Lee
Joseph H
JH
Cheng
Rong
R
St George-Hyslop
Peter
P
Mayeux
Richard
R
Farrer
Lindsay A
LA
D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D030541:Databases, Genetic; D005060:Europe / Q000453:epidemiology; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human