title: Quantitative solubility relationships and the effect of water uptake in triglyceride/monoglyceride microemulsions.
abstract: OBJECTIVE
  This paper aims to elucidate quantitative relationships between small molecule solubility/water-uptake in triglyceride/monoglyceride lipid formulations, the chemical structure of the solute, and the solvent composition.
  
  
  METHODS
  Solubility and water uptake in tricaprylin/1-monocaprylin and tricaprylin/1-monocaprin mixtures in the "microemulsion" region at 37 degrees C were determined with HPLC and KF coulometry, respectively. Twelve model solutes varying in hydrogen bond acidity, basicity, polarity, and molecular volume were chosen. Linear free energy relationships (LFER) (Abraham type) were implemented to obtain solvent coefficients at various monoglyceride concentrations.
  
  
  RESULTS
  Profiles for both solubility and water uptake (at different water activities) in lipid mixtures containing different monoglycerides were superimposable, producing a single master curve when the monoglyceride concentrations were plotted on a molar scale. The LFER derived solvent coefficients showed a systematic dependence on the lipid composition consistent with the view that relative solubility is determined largely by the molar concentrations of individual functional groups such as glyceride ester moieties and hydroxyl groups. At low RH, water uptake increased linearly with monoglyceride concentration while cooperativity was evident in water uptake profiles at high RH.
  
  
  CONCLUSIONS
  This study provides a potential universal framework for predicting relative drug solubility in mixtures containing fully saturated triglycerides and monoglycerides.
authors: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323A, ASTeCC Building, Lexington, KY 40536, USA.
authors: Sagar S
authors: SS
authors: Rane
authors: Yichen
authors: Y
authors: Cao
authors: Bradley D
authors: BD
authors: Anderson
mesh_terms: D000465:Algorithms; D002210:Caprylates / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D006813:Humidity; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D008958:Models, Molecular; D050178:Monoglycerides / Q000737:chemistry*; D009821:Oils; D012044:Regression Analysis; D012995:Solubility; D014280:Triglycerides / Q000737:chemistry*; D014867:Water / Q000032:analysis
chemical_list: D002210:Caprylates; D004655:Emulsions; D005079:Excipients; D007202:Indicators and Reagents; D050178:Monoglycerides; D009821:Oils; D014280:Triglycerides; D014867:Water; C003637:tricaprylin