[Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management].
Eosinophilic esophagitis (EE) is a relatively new, chronic, TH 2-type allergic inflammation of the esophagus. EE occurs more frequently in men. Allergic diseases such as asthma or atopic dermatitis are present in 50-70 % of patients or their relatives. In adults, the most common presenting symptom of EE is dysphagia, with or without food bolus impaction. Endoscopic findings of EE include mucosal furrows, corrugated or concentric rings or ridges in the esophagus ("feline esophagus"), with or without tiny whitish exudates. The diagnosis is confirmed by the observation of high counts of eosinophils in the esophageal epithelium (at least 24 /HPF). The cornerstones of medical therapy are either topical or systemic corticosteroids. Additional therapies included leukotriene receptor antagonists (montelukast) and IL-5 blockers (Mepolizumab). Complications of EE such as esophageal strictures should be carefully dilated using either bougies or a balloon. Currently it is still not known whether the late complications of EE can be prevented by the use of anti-inflammatory agents and this can only be demonstrated through further long-term follow-up studies.
von Arnim
U
U
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Otto-von-Guericke-Universität Magdeburg, Deutschland.
Mönkemüller
K
K
Malfertheiner
P
P
Straumann
A
A
D000085:Acetates / Q000008:administration & dosage; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D001630:Bezoars / Q000209:etiology; D002404:Catheterization; D003521:Cyclopropanes; D003680:Deglutition Disorders / Q000209:etiology; D004802:Eosinophilia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D004804:Eosinophils / Q000276:immunology; D004941:Esophagitis / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D004945:Esophagoscopy; D006801:Humans; D007958:Leukocyte Count; D011804:Quinolines / Q000008:administration & dosage; D013440:Sulfides; D018418:Th2 Cells / Q000276:immunology
D000085:Acetates; D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; C434107:mepolizumab; C093875:montelukast