title: HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART.
abstract: As immune recovery during HAART is mainly caused by the expansion of X4-naive cells, we studied the evolution of HIV tropism in the reservoir of 34 patients receiving 48 weeks of HAART. No change in virus tropism was observed over time, but patients with X4 viruses had higher HIV-1 proviral DNA levels than patients with R5 viruses. This suggests that CCR5 antagonist activity should not be compromised in patients harbouring R5 viruses before starting HAART.
authors: Department of Virology-EA2387, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France.
authors: Cathia
authors: C
authors: Soulié
authors: Anne-Geneviève
authors: AG
authors: Marcelin
authors: Jade
authors: J
authors: Ghosn
authors: Bahia
authors: B
authors: Amellal
authors: Lambert
authors: L
authors: Assoumou
authors: Sidonie
authors: S
authors: Lambert
authors: Claudine
authors: C
authors: Duvivier
authors: Dominique
authors: D
authors: Costagliola
authors: Christine
authors: C
authors: Katlama
authors: Vincent
authors: V
authors: Calvez
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D004279:DNA, Viral / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011533:Proviruses; D019713:Receptors, CCR5 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*; D013997:Time Factors; D018523:Tropism; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D004279:DNA, Viral; D019713:Receptors, CCR5; D019718:Receptors, CXCR4