title: In vivo ultrahigh-resolution optical coherence tomography.
abstract: Ultrahigh-resolution optical coherence tomography (OCT) by use of state of the art broad-bandwidth femtosecond laser technology is demonstrated and applied to in vivo subcellular imaging. Imaging is performed with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm, centered at 800 nm. Longitudinal resolutions of ~1mum and transverse resolution of 3mum, with a 110-dB dynamic range, are achieved in biological tissue. To overcome depth-of-field limitations we perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth. To our knowledge this is the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.
authors: W
authors: W
authors: Drexler
authors: U
authors: U
authors: Morgner
authors: F X
authors: FX
authors: Kärtner
authors: C
authors: C
authors: Pitris
authors: S A
authors: SA
authors: Boppart
authors: X D
authors: XD
authors: Li
authors: E P
authors: EP
authors: Ippen
authors: J G
authors: JG
authors: Fujimoto