[The clinical significance of immunohistochemically detectable Ki-67 protein in renal cell carcinoma].
Great attention is paid to renal cell carcinoma (RCC) due to the growth of its prevalence. This paper is dedicated to the matching of classic clinical and pathological prognostic factors to the character of the expression of proliferation marker Ki-67 in this kind of cancer. The proliferative activity was analyzed in 101 RCC cases by immunohistochemical assays using antibodies to Ki-67. In aggressive RCC and Fuhrman grade 3 to 4 tumors, Ki-67 level was found to be high more often. Besides, time to the appearance of remote metastases was significantly shorter, and total survival rate was significantly lower in RCC with high proliferative activity vs. low.
Lazarev
A F
AF
Doroshenko
V S
VS
Varlamov
S A
SA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000276:immunology*; D007680:Kidney Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D019394:Ki-67 Antigen