Viewpoint: Discriminating between noncompetitive and allosteric interactions.
Understanding inhibition modes other than competitive is of clear importance in neuropharmacology. However, there appears to be some confusion concerning modes of inhibition that are not of the competitive type. It is critical to make a distinction between "not competitive" and "noncompetitive," as the later is a particular mode of inhibition. Further, there appears to be confusion between noncompetitive and allosteric behavior. Our purpose in this contribution is to explore the basis of these terms so that insight into pharmacological systems has a firmer mechanistic basis.
Ochs
Raymond S
RS
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA. ochsr@stjohns.edu
Ashby
Charles R
CR
D000494:Allosteric Regulation / Q000502:physiology; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D008956:Models, Chemical; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship