title: Enterococcal endocarditis associated with crescentic glomerulonephritis.
abstract: Glomerulonephritis secondary to infective endocarditis (IE) is an uncommon diagnosis and is usually associated with cardiac valvular infection by blood-culture-positive bacteria. We report a case of necrotizing glomerulonephritis associated with culture-positive endocarditis caused by Enterococcus faecalis. The patient presented with renal abnormalities and was further investigated by renal biopsy. He had immune complex-mediated necrotizing and crescentic glomerulonephritis with mesengial and capillary deposition of immunoglobulin M (Ig M), Ig G, and complement 3 (C3). He was treated with antibiotics, including ampicillin and gentamicin. In addition, steroid and cyclophosphamide were administered. The patient died of renal failure 48 days after hospital admission. In conclusion, glomerulonephritis caused by Enterococcus faecalis endocarditis is an immune-complex-mediated disease characterized by necrotizing and crescentic glomerular lesions that can be fatal despite aggressive antimicrobial and immunosuppressive therapy.
authors: Department of Internal Medicine, Nephrology Unit, Hacettepe University, School of Medicine, Eriskin Nefroloji Bolumu 06100, Sihhiye, Ankara, Turkey. alperk@hacettepe.edu.tr.
authors: Alper
authors: A
authors: Kirkpantur
authors: Department of Internal Medicine, Hacettepe University, School of Medicine, Ankara, Turkey.
authors: Akif
authors: A
authors: Altinbas
authors: Department of Internal Medicine, Nephrology Unit, Hacettepe University, School of Medicine, Eriskin Nefroloji Bolumu 06100, Sihhiye, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Arici
authors: Department of Pathology, Hacettepe University, School of Medicine, Ankara, Turkey.
authors: Dilek Ertoy
authors: DE
authors: Baydar
authors: Department of Internal Medicine, Nephrology Unit, Hacettepe University, School of Medicine, Eriskin Nefroloji Bolumu 06100, Sihhiye, Ankara, Turkey.
authors: Bulent
authors: B
authors: Altun
authors: Department of Internal Medicine, Gastroenterology Unit, Hacettepe University, School of Medicine, Ankara, Turkey.
authors: Serap
authors: S
authors: Arslan
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D013293:Enterococcus faecalis / Q000302:isolation & purification*; D017809:Fatal Outcome; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007673:Kidney Cortex Necrosis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents