Accuracy of endoscopic ultrasound in the diagnosis of distal and celiac axis lymph node metastasis in esophageal cancer: a meta-analysis and systematic review.
BACKGROUND
Published data on the accuracy of endoscopic ultrasound (EUS) for staging distant and celiac axis lymph node (CLN) metastasis in patients with esophageal cancer (ECA) has varied.


OBJECTIVE
To evaluate the accuracy of EUS in diagnosing distal and CLN metastasis in ECA patients.


METHODS



METHODS
EUS studies confirmed by surgery were selected.


METHODS
Pooling was conducted by both fixed and random-effects models.


RESULTS
Data were extracted from 25 studies (N = 2029) which met the inclusion criteria. In ECA patients, pooled sensitivity of EUS was 67.2% (95% CI: 62.6-71.6) in diagnosis of distal metastasis and 66.6% (95% CI: 61.9-71.1) in diagnosis of CLN metastasis. EUS had a pooled specificity of 97.9% (95% CI: 97.1-98.6) for distal metastasis and 98.1% (95% CI: 97.3-98.7) for CLN metastasis.


CONCLUSIONS
Although EUS has excellent specificity in accurately diagnosing distal and CLN metastasis in patients with ECA, the sensitivity is low.
Puli
Srinivas R
SR
Division of Gastroenterology and Hepatology, University of Missouri-Columbia, One Hospital Drive, Columbia, MO 65212, USA.
Reddy
Jyotsna B K
JB
Bechtold
Matthew L
ML
Antillon
Mainor R
MR
Ibdah
Jamal A
JA
D000005:Abdomen; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D010537:Peritoneum; D012680:Sensitivity and Specificity