Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?
A recent paper (Hayashi et al. 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk-2/Rad-5, physically interacts with all the phosphoinositide 3-kinase-related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK-related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.
Kanoh
Junko
J
Graduate School of Biostudies, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. jkanoh@lif.kyoto-u.ac.jp
Yanagida
Mitsuhiro
M
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D034501:Telomere-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D029702:Schizosaccharomyces pombe Proteins; C518817:Tel2 protein, S pombe; D034501:Telomere-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases