Apoptotic PS to phagocyte TIM-4: eat me.
Although cells dying by apoptosis expose the classical "eat me" signal phosphatidylserine (PS), a phagocytic transmembrane receptor for PS has proved elusive. Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4.
Savill
John
J
MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. headcmvm@miscorp.ed.ac.uk
Gregory
Chris
C
D000818:Animals; D017209:Apoptosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D010587:Phagocytosis; D010718:Phosphatidylserines / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*
C491143:HAVCR1 protein, human; C442240:Havcr1 protein, mouse; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D010718:Phosphatidylserines; D011991:Receptors, Virus; C500399:TIM-4 protein, mouse; C512411:TIMD4 protein, human