title: Acid-base interpretation can be the predictor of outcome among patients with acute organophosphate poisoning before hospitalization.
abstract: OBJECTIVE
  Acute organophosphate (OP) poisoning causing alteration in acid-base equilibrium was reported before. Hence, different acid-base statuses may present in patients with acute poisoning due to OP exposure. This study aims to determine the impact of acid-base interpretation in patients with acute OP poisoning before hospitalization in medical care units and to describe the pattern of mortality with different acid-base statuses.
  
  
  METHODS
  Over a 9-year retrospective study, from July 1996 to August 2005, a total of 82 consecutive patients with acute OP poisoning were admitted to the China Medical University Hospital (Taichung, Taiwan) within 24 hours after exposure to OP and were enrolled into this study.
  
  
  RESULTS
  Patients with acute OP poisoning were divided into 4 groups: without acidosis, metabolic acidosis, respiratory acidosis, and mixed acidosis. Overall survival (Kaplan-Meier curves) among groups was statistically significant (P < .0001). The mortality rate of acute OP poisoned patients with metabolic acidosis was 25%, and 75% of those patients died of cardiovascular failure. The mortality rate of acute OP poisoning with respiratory acidosis was 50%, and 50% of those patients died of respiratory failure.
  
  
  CONCLUSIONS
  Acid-base interpretation can be effective in quick diagnosis and prediction of the outcome of patients with acute OP poisoning (without acidosis < metabolic acidosis < respiratory acidosis < mixed acidosis) before hospitalization. Major causes of death are different between the respiratory acidosis and metabolic acidosis groups of patients with acute OP poisoning.
authors: Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: Jiung-Hsiun
authors: JH
authors: Liu
authors: Che-Yi
authors: CY
authors: Chou
authors: Yao-Lung
authors: YL
authors: Liu
authors: Pen-Yuan
authors: PY
authors: Liao
authors: Po-Wen
authors: PW
authors: Lin
authors: Hsin-Hung
authors: HH
authors: Lin
authors: Ya-Fei
authors: YF
authors: Yang
mesh_terms: D000137:Acid-Base Imbalance / Q000139:chemically induced* / Q000401:mortality*; D000138:Acidosis / Q000139:chemically induced / Q000401:mortality; D000142:Acidosis, Respiratory / Q000139:chemically induced / Q000401:mortality; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome