title: CSF histamine levels in rats reflect the central histamine neurotransmission.
abstract: Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels, we measured the levels in rats across 24h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data.
authors: Sleep and Circadian Neurobiology Laboratory, Center for Narcolepsy, Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Palo Alto, CA 94304, USA.
authors: Atsushi
authors: A
authors: Soya
authors: You Hwi
authors: YH
authors: Song
authors: Tohru
authors: T
authors: Kodama
authors: Yoshiko
authors: Y
authors: Honda
authors: Nobuhiro
authors: N
authors: Fujiki
authors: Seiji
authors: S
authors: Nishino
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D005508:Food Deprivation / Q000502:physiology; D006632:Histamine / Q000134:cerebrospinal fluid*; D008297:Male; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012892:Sleep Deprivation / Q000378:metabolism / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D010880:Piperidines; D006632:Histamine; D000661:Amphetamine; C052075:thioperamide; D000077408:Modafinil