Genetic association of preeclampsia to the inflammatory response gene SEPS1.
OBJECTIVE
The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.


METHODS
A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by chi2 and multivariate regression analyses.


RESULTS
Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).


CONCLUSIONS
The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.
Moses
Eric K
EK
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. moses@darwin.sfbr.org
Johnson
Matthew P
MP
Tømmerdal
Linda
L
Forsmo
Siri
S
Curran
Joanne E
JE
Abraham
Lawrence J
LJ
Charlesworth
Jac C
JC
Brennecke
Shaun P
SP
Blangero
John
J
Austgulen
Rigmor
R
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D012189:Retrospective Studies; D051140:Selenoproteins / Q000235:genetics*
D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins