title: Osteomyelitis and the role of biofilms in chronic infection.
abstract: Understanding the mechanisms implicated in the initial attachment, development, and maturation of a biofilm phenotype are of tremendous importance for their effect on the medical, industrial, and public health arenas. This review explores the current understanding of the nature of biofilms and the impact that molecular interactions between the bacteria themselves, as well as between bacteria and the host, may have on biofilm development and phenotype using the nonmotile Gram-positive coccus, Staphylococcus aureus, as an example.
authors: Department of Microbiology and Immunology, University of Maryland-Baltimore, School of Medicine, Baltimore, MD 21201, USA.
authors: Rebecca A
authors: RA
authors: Brady
authors: Jeff G
authors: JG
authors: Leid
authors: Jason H
authors: JH
authors: Calhoun
authors: J William
authors: JW
authors: Costerton
authors: Mark E
authors: ME
authors: Shirtliff
mesh_terms: D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D006801:Humans; D010019:Osteomyelitis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*