Synthesis, characterization, DNA-binding properties of the Ln(III) complexes with 6-hydroxy chromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone.
6-Hydroxy chromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone (L) and its Ln (III) complexes, [Ln = La, Nd, Eu and Tb] have been prepared and characterized on the basis of elemental analyses, molar conductivities, mass spectra, (1)H NMR, thermogravimetry/differential thermal analysis (TG-DTA), UV-vis spectra, fluorescence spectra and IR spectra. The formula of the complex is [Ln L.(NO(3))(2)].NO(3). Spectrometric titration, ethidium bromide displacement experiments and viscosity measurements indicate that Eu (III) complex bind with calf-thymus DNA, presumably via an intercalation mechanism. The intrinsic binding constant of Eu (III) with DNA was 2.48 x 10(5) M(-1) through fluorescence titration data.
Wang
Bao-Dui
BD
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.
Yang
Zheng-Yin
ZY
D000818:Animals; D002417:Cattle; D002867:Chromones / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D005063:Europium / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry* / Q000378:metabolism; D007202:Indicators and Reagents / Q000737:chemistry / Q000378:metabolism; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
C514206:6-hydroxy chromone-3-carbaldehyde-(2'-hydroxy) benzoyl hydrazone; D002867:Chromones; D006835:Hydrazones; D007202:Indicators and Reagents; D028581:Lanthanoid Series Elements; D005063:Europium; D004247:DNA; C427203:calf thymus DNA