Elevated plasma leptin levels associated with high blood pressure and TG rich lipoproteins but not associated with plasma gonadotropins, estradiol and cortisol levels in peri- and postmenopausal lean women with undefined symptoms.
We evaluated associations of leptin with blood pressure, plasma lipid metabolism, and endocrine status in 140 perimenopausal Japanese women. In this study, the mean plasma leptin level is 8.6 +/- 4.8 ng/ml and the range is 1.7 to 29.6 ng/ml. There were significant correlations between plasma leptin concentration and systolic blood pressure (r +/- 0.647, p < 0.0001) and diastolic blood pressure (r = 0.242, p = 0.0043). We observed significant correlation of plasma leptin concentration and LDL-cholesterol, triglyceride concentrations. However, no significant differences were observed in the correlation of plasma leptin and LH, FSH, estradiol and cortisol concentrations. In conclusion, leptin showed a significant association with blood pressure and lipid metabolism. It is suggested that leptin may play an important role in physiological regulation of sympathetic nervous system and lipid metabolism in peri-and postmenopausal women.
Ushiroyama
T
T
Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp
Ikeda
A
A
Higashio
S
S
Sakuma
K
K
Ueki
M
M
D004958:Estradiol / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D047648:Perimenopause / Q000097:blood; D017698:Postmenopause / Q000097:blood; D014280:Triglycerides / Q000097:blood*
D006065:Gonadotropins, Pituitary; D020738:Leptin; D008074:Lipoproteins; D014280:Triglycerides; D004958:Estradiol; D006854:Hydrocortisone