[Immunological aspects of aphthous stomatitis].
The purpose of the present work was to study the role of cellular and humoral immunity in patients with aphthous stomatitis. The research was conducted at Tbilisi Hospital for War Veterans. Immunologic parameters of 61 patients aged from 15 to 60 years old were analyzed. The statistical data processing included calculation of average arithmetic values and their standard deviations. Parameters of the immune status of the patients during exacerbation and under treatment were investigated. It was revealed that during exacerbation of stomatitis the quantity of CD3, CD4, cytophagous activity, and NK were diminished. Indices of CD8, CD72, and IgA, were within the norm. Indices of IgM, IgG, IgE, parameter of IL-6, antimicrobial and antitoxic antibody titer were increased. After treatment increase and approach to standard CD3, CD4, NK, and parameters of phagocytosis. IgG, IgM and antitoxic antibody titer decrease and approach to standard. During exacerbation of recurrent aphthous stomatitis the immune status of the human decrease, this is restored after treatment.
Koridze
Kh
Kh
Tbilisi Hospital of the Veterans of War; O. Gudusha-uri National Medical Center; Georgian State Medical University.
Ladashvili
L
L
Taboridze
I
I
Bakradze
M
M
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000187:drug effects; D004145:Diosmin / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006569:Hesperidin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000187:drug effects / Q000276:immunology; D007074:Immunoglobulin G / Q000187:drug effects / Q000276:immunology; D007075:Immunoglobulin M / Q000187:drug effects / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013281:Stomatitis, Aphthous / Q000276:immunology* / Q000628:therapy
D015703:Antigens, CD; D004338:Drug Combinations; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; C080675:S 5682; D004145:Diosmin; D006569:Hesperidin