title: Solid-phase total synthesis and antimicrobial activities of loloatins A-D.
abstract: The first total synthesis of the decapeptide antibiotics loloatins A-D (1-4), originally isolated from the marine bacterial isolate MK-PNG-276A, possibly in the genus Bacillus, was accomplished by solid-phase peptide synthesis (SPPS), followed by 'head-to-tail' cyclization of the activated linear precursors, without protection of nucleophilic side-chain functions, on a safety-catch resin. The synthetic peptides were equally active as the natural products isolated from the bacterial source and found to possess similar bacterial selectivity as other members in the family of amphipathic antimicrobial cyclic decapeptides.
authors: Faculty of Life Science, Northwestern Polytechnical University, P.O. Box 707, 127 West Friendship Road, Xi'an 710072, Shaanxi Province, PR China.
authors: Yan
authors: Y
authors: Ding
authors: Chuanguang
authors: C
authors: Qin
authors: Zhihong
authors: Z
authors: Guo
authors: Weining
authors: W
authors: Niu
authors: Ruijie
authors: R
authors: Zhang
authors: Yang
authors: Y
authors: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides