title: Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight.
abstract: We have previously shown that the generation of antibodies to a polysaccharide vaccine (Typhim Vi) is compromised in Pakistani adults born of a lower birth weight. To assess whether this represents a true B-cell-dependent deficit, we revaccinated subjects with a second dose of the same vaccine and with a polysaccharide-protein conjugate vaccine to a different polysaccharide antigen (conjugated Haemophilus influenzae type b (Hib) vaccine). Anti-Vi IgG levels remained positively correlated with birth weight (p=0.0284) but no associations were observed between anti-Hib IgG levels and size at birth. These findings indicate that small size at birth results in a poor antibody response to vaccination with a polysaccharide antigen vaccine in adulthood, even following a second dose of the vaccine. No such association was observed in response to a polysaccharide-protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response.
authors: MRC Keneba, Medical Research Council Laboratories, Fajara, P.O. Box 273, Banjul, Gambia. Sophie.Moore@lshtm.ac.uk <Sophie.Moore@lshtm.ac.uk>
authors: Sophie E
authors: SE
authors: Moore
authors: Fehmida
authors: F
authors: Jalil
authors: Shousun Chen
authors: SC
authors: Szu
authors: Mirjana
authors: M
authors: Hahn-Zoric
authors: Andrew M
authors: AM
authors: Prentice
authors: Lars A
authors: LA
authors: Hanson
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000097:blood; D007230:Infant, Low Birth Weight / Q000276:immunology*; D007231:Infant, Newborn; D008297:Male; D010154:Pakistan; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial; D014436:Typhoid-Paratyphoid Vaccines; D018074:Vaccines, Conjugate; C057664:Vi polysaccharide vaccine, typhoid