title: Structural analogs of tylophora alkaloids may not be functional analogs.
abstract: Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-kappaB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs.
authors: Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Wenli
authors: W
authors: Gao
authors: Annie Pei-Chun
authors: AP
authors: Chen
authors: Chung-Hang
authors: CH
authors: Leung
authors: Elizabeth A
authors: EA
authors: Gullen
authors: Alois
authors: A
authors: Fürstner
authors: Qian
authors: Q
authors: Shi
authors: Linyi
authors: L
authors: Wei
authors: Kuo-Hsiung
authors: KH
authors: Lee
authors: Yung-Chi
authors: YC
authors: Cheng
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D031110:Tylophora / Q000737:chemistry*
chemical_list: D000470:Alkaloids