A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines.
Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in good yield. The reaction mechanism is believed to involve a free-radical sequence resulting in an imino alcohol subsequently reduced to product.
Russell
Henry F
HF
Department of Science and Mathematics, Johnson C. Smith University, Charlotte, NC 28216, USA.
Bremner
John B
JB
Bushelle-Edghill
Jennifer
J
Lewis
Melissa R
MR
Thomas
Stacey R
SR
Bates
Floyd
F