[Renal disease in multiple myeloma].
Renal involvement is common in multiple myeloma. Although several types of renal disease are observed, most of them are considered to be specifically related to monoclonal immunoglobulin light chains. Myeloma cast nephropathy is the most frequent and sometimes associated with acute renal failure. AL amyloidosis and monoclonal immunoglobulin deposit disease are often presented as a nephrotic syndrome. In this review, we describe the pathogenesis and diagnosis of these three renal diseases. We also focus on the treatment of renal disease in multiple myeloma, in the view points of the chemotherapy to reduce M-protein and the prevention to reduce the risks of promoting renal injury.
Hiromura
Keiju
K
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine.
Nojima
Yoshihisa
Y
D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015415:Biomarkers / Q000032:analysis; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D007147:Immunoglobulin Light Chains; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000150:complications*; D009194:Myeloma Proteins / Q000032:analysis; D010951:Plasma Exchange; D011239:Prednisolone / Q000008:administration & dosage
D015415:Biomarkers; D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins; D003907:Dexamethasone; D011239:Prednisolone; D008558:Melphalan