Normal and pathologic tissue reactions to soft tissue gel fillers.
BACKGROUND
All gels act as foreign bodies. Host response ranges from a few macrophages to an intense foreign-body reaction with fibrosis, depending on gel type. For polymer gels the filling effect stems from their volume. For combination gels it stems from the intended host foreign-body reaction to the microparticles.


OBJECTIVE
This review explains how host tissue reacts with different gel types and how adverse reactions differ depending on gel type.


METHODS
This study is based on observations during the past 6 1/2 years from experimental/clinical studies and biopsies from adverse reactions.


RESULTS
Hydrophilic polymer gels constantly exchange water with their host tissue with minimal fibrosis. Degradable gels are encircled and degraded by macrophages; polyacrylamide gel is traversed by macrophages, replaced by fibrous, vessel-bearing strands. All other gels provoke a foreign-body reaction with ensuing fibrosis. Adverse reactions include bacterial infection for the hydrophilic gels and a fibrous granuloma for all other gel types. It is hypothesized that bacteria are maintained within a biofilm (a film comprising bacteria, their nutrients, and their waste products) giving rise to a low-grade infection.


CONCLUSIONS
Infectious nodules must be treated with antibiotics. Granulomas must be treated with a combination of both steroids and antibiotics or excision.
Christensen
Lise
L
Department of Pathology, Bispebjerg University Hospital, Copenhagen, Denmark. LC24@bbh.regionh.dk
D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects; D003357:Cosmetic Techniques; D005549:Foreign-Body Reaction / Q000209:etiology*; D005782:Gels / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects; D020100:Hydrogels / Q000008:administration & dosage / Q000009:adverse effects; D007267:Injections / Q000009:adverse effects; D011108:Polymers / Q000008:administration & dosage / Q000009:adverse effects; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects
D001672:Biocompatible Materials; D005782:Gels; D020100:Hydrogels; D011108:Polymers; D012828:Silicones; D006820:Hyaluronic Acid; D003094:Collagen