The synthesis and chelation chemistry of DOTA-peptide conjugates.
Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA-peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA-peptide conjugate metal complexes.
De León-Rodríguez
Luis M
LM
University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road NE 4.2, Dallas, Texas 75390-8568, USA.
Kovacs
Zoltan
Z
D002614:Chelating Agents / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D010455:Peptides; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid