Sustained release carriers used to delivery bone morphogenetic proteins in the bone healing process.
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor beta superfamily, especially BMP-2, induce bone formation in vivo, and clinical application in repair of bone fractures and defects is expected. However, appropriate systems to delivery BMPs for practical use need to be developed with the objective to heal cartilage and bone-related diseases in medical, dental and veterinary practice. Thus, the aim of this article was to present an overview of the principals carriers used to delivery BMPs and alternative delivery systems for these proteins.
Issa
J P M
JP
Faculty of Dentistry, University of São Paulo, Avendia do Café S/N, Riberão Preto, São Paulo, Brazil. jpmissa@forp.usp.br
Bentley
M V L B
MV
Iyomasa
M M
MM
Sebald
W
W
De Albuquerque
R F
RF
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods / Q000662:veterinary*; D050723:Fractures, Bone / Q000188:drug therapy*; D016212:Transforming Growth Factor beta / Q000008:administration & dosage; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016212:Transforming Growth Factor beta