title: Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study.
abstract: In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.
authors: Istituto di Biostutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy. domymusu@alice.it
authors: D
authors: D
authors: Musumeci
authors: Giovanni N
authors: GN
authors: Roviello
authors: M
authors: M
authors: Moccia
authors: C
authors: C
authors: Pedone
authors: E M
authors: EM
authors: Bucci
authors: R
authors: R
authors: Sapio
authors: M
authors: M
authors: Valente
authors: S
authors: S
authors: Fumero
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000494:pharmacology*; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors*; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D024243:HMGB1 Protein; D009841:Oligonucleotides; C477371:locked nucleic acid; D004247:DNA