title: Morphological and histological findings after typical surgical manipulations on growing septal cartilage in rabbits.
abstract: One remaining problem of nose surgery is surgical correction of a prepubertal distortion of the septum. Unfortunately, the growing cartilage reacts differently upon a surgical intervention; in most cases this might cause iatrogenic disturbance of the development. Our clinical and histological studies with polydioxanone (PDS) foil in septal reconstruction showed that the PDS foil successfully prevented postoperative sequelae like dislocation of the reimplanted cartilage fragments and recurrent deviation caused by overlapping of the cartilage borders. Furthermore, it seemed to stimulate cartilage regeneration. The question occurs whether the same effect can be expected if growing septal cartilage is supported by the PDS foil. This animal study showed remarkable effects of the resorbable PDS foil in healing and regeneration of the growing septum up to complete resorption of the PDS, which coincidentally paralleled the outgrowth of the septal cartilage in rabbits, such as in cartilage regeneration and in prevention of secondary septal deviations due to bending of the newly formed cartilage or incomplete healing of cut edges.
authors: Medicent Linz, Amsterdam, The Netherlands.
authors: Miriam
authors: M
authors: Boenisch
authors: Hajas
authors: H
authors: Tamas
authors: Gilbert J
authors: GJ
authors: Nolst Trenité
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D020219:Chondrogenesis; D005260:Female; D009300:Nasal Septum / Q000254:growth & development* / Q000473:pathology / Q000601:surgery*; D009667:Nose Deformities, Acquired / Q000209:etiology / Q000517:prevention & control*; D016687:Polydioxanone / Q000627:therapeutic use*; D011817:Rabbits; D012038:Regeneration; D012225:Rhinoplasty / Q000009:adverse effects / Q000295:instrumentation*; D053831:Surgical Fixation Devices
chemical_list: D016687:Polydioxanone