title: Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China.
abstract: OBJECTIVE
  To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population.
  
  
  METHODS
  In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia and 156 age-matched controls with normal sperm concentration and motility, according to the criteria adapted from World Health Organization guidelines. All of the patients and controls were from northwestern China.
  
  
  RESULTS
  There is a significant association between GSTT1 null genotype with idiopathic azoospermia risk (odds ratio [OR]: 2.36, 95% confidence interval [CI]: 1.33-4.20, P=0.003) or idiopathic oligospermia risk (OR: 2.00, 95% CI: 1.17-3.27, P=0.010).
  
  
  CONCLUSIONS
  GSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China.
authors: Department of Urology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors: Qi-Fei
authors: QF
authors: Wu
authors: Jun-Ping
authors: JP
authors: Xing
authors: Kai-Fa
authors: KF
authors: Tang
authors: Wei
authors: W
authors: Xue
authors: Min
authors: M
authors: Liu
authors: Jian-Hua
authors: JH
authors: Sun
authors: Xin-Yang
authors: XY
authors: Wang
authors: Xiao-Juan
authors: XJ
authors: Jin
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013081:Sperm Motility / Q000235:genetics*
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase