Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.
A 37-year-old female patient was diagnosed with ulcerative colitis 8 months ago and medical treatment with oral azathioprine, low-dose corticosteroids and 5-ASA was started. Following 3 months without any symptoms, the patient had total colectomy and ileostomy. After this period, liposomal amphotericin B (3 mg kg(-1) day(-1)) was given with the diagnosis of probable fungal infection. Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment. Histological examination of a skin biopsy was consistent with leucocytoclastic vasculitis. We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.
Cagatay
A Atahan
AA
Taranoglu
Ozer
O
Alpay
Nilufer
N
Tufan
Fatih
F
Karadeniz
Asli
A
Kapmaz
Mahir
M
Buyukbabani
Nesimi
N
D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D012871:Skin Diseases / Q000473:pathology*; D014657:Vasculitis / Q000473:pathology*
D000666:Amphotericin B