title: High prevalence of sleep disorders in hemodialyzed patients requiring parathyroidectomy.
abstract: OBJECTIVE
  Although there has been contrasting evidence for a causative role of parathyroid hormone (PTH) in sleep disorders in patients on maintenance hemodialysis, a recent study disclosed the possibility that this role might exist at least in patients requiring parathyroidectomy because of failure of medical therapy. The present study was devised to assess a possible difference in sleep disorders of patients on hemodialysis needing parathyroidectomy and those in whom medical therapy controlled hyperparathyroidism.
  
  
  METHODS
  To this end, a group of 22 patients requiring parathyroidectomy were studied by means of a sleep questionnaire, along with a group of 44 patients matched for age, gender, body weight, and duration of dialytic treatment.
  
  
  RESULTS
  Patients requiring parathyroidectomy slept fewer hours (P < .001), had a higher prevalence of sleep disorders (P < .001), and were more often insomniac (P < .001).
  
  
  CONCLUSIONS
  This study indicates that patients on hemodialysis requiring parathyroidectomy for intractable hyperparathyroidism comprise a good model for investigating the causative role of PTH on disordered sleep, and that these patients have very poor sleep. These data support recent findings on the prevalence of sleep disorders in dialyzed patients with insuppressible hyperparathyroidism.
authors: Unit for Psychological Support, Dialysis Unit Neoren, Montesarchio, Benevento, Italy. bluetoblue@libero.it
authors: Rosa Maria
authors: RM
authors: De Santo
authors: Maria Grazia
authors: MG
authors: Esposito
authors: Concetta Maria
authors: CM
authors: Cesare
authors: Gennaro
authors: G
authors: Cice
authors: Alessandra
authors: A
authors: Perna
authors: Eleonora
authors: E
authors: Violetti
authors: Giovanni
authors: G
authors: Conso
authors: Giancarlo
authors: G
authors: Bilancio
authors: Salvatore
authors: S
authors: Celsi
authors: Massimo
authors: M
authors: Cirillo
authors: Antonio
authors: A
authors: Livrea
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000009:adverse effects*; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000453:epidemiology; D012893:Sleep Wake Disorders / Q000453:epidemiology*
chemical_list: D010281:Parathyroid Hormone