title: The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease.
abstract: Scavenger receptors are membrane glycoproteins that bind diverse ligands including lipid particles, phospholipids, apoptotic cells and pathogens. LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is increasingly linked to atherosclerotic plaque formation. Transgenic mouse models for LOX-1 overexpression or gene knockout suggests that LOX-1 contributes to atherosclerotic plaque formation and progression. LOX-1 activation by oxidized LDL (low-density lipoprotein) binding stimulates intracellular signalling, gene expression and production of superoxide radicals. A key question is the role of leucocyte LOX-1 in pro-atherogenic lipid particle trafficking, accumulation and signalling leading to differentiation into foam cells, necrosis and plaque development. LOX-1 expression is elevated within vascular lesions and a serum soluble LOX-1 fragment appears diagnostic of patients with acute coronary syndromes. LOX-1 is increasingly viewed as a vascular disease biomarker and a potential therapeutic target in heart attack and stroke prevention.
authors: Endothelial Cell Biology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK.
authors: Sarah
authors: S
authors: Dunn
authors: Ravinder S
authors: RS
authors: Vohra
authors: Jane E
authors: JE
authors: Murphy
authors: Shervanthi
authors: S
authors: Homer-Vanniasinkam
authors: John H
authors: JH
authors: Walker
authors: Sreenivasan
authors: S
authors: Ponnambalam
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D015415:Biomarkers; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008024:Ligands; D008077:Lipoproteins, LDL / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D021381:Protein Transport; D051127:Scavenger Receptors, Class E / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D008024:Ligands; D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E