Treatment-related ureteral cancer following stage II testicular seminoma.
We report two cases of left ureteral carcinoma that may have been related to prior radiotherapy and anticancer chemotherapy for stage II testicular seminoma. Both patients had undergone radiotherapy (60 Gy) and cisplatin-based chemotherapy, one 17 years before the present presentation and the other 24 years earlier. They underwent retroperitoneoscopy-assisted left nephroureterectomy under a diagnosis of left upper ureteral cancer, established by means of ureteroscopy and brush biopsy. The urologic and radiologic outcomes have been satisfactory after more than 2 years of follow-up. Recently, some investigators have reported that testicular cancer survivors are at significantly increased risk of solid tumors for at least 35 years after treatment. Young patients may have a high risk of cancer when they reach an advanced age.
Mizutani
Kosuke
K
Department of Urology, Gifu University Hospital, Gifu, Japan.
Ehara
Hidetoshi
H
Yokoi
Shigeaki
S
Phuoc
Nguyen B
NB
Deguchi
Takashi
T
Hirose
Yoshinobu
Y
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D011878:Radiotherapy / Q000009:adverse effects*; D018239:Seminoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D016896:Treatment Outcome; D014516:Ureteral Neoplasms / Q000209:etiology* / Q000601:surgery
D000970:Antineoplastic Agents; D002945:Cisplatin