title: Efficient C2 functionalisation of 2H-2-imidazolines.
abstract: Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).
authors: Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
authors: Robin S
authors: RS
authors: Bon
authors: Nanda E
authors: NE
authors: Sprenkels
authors: Manoe M
authors: MM
authors: Koningstein
authors: Rob F
authors: RF
authors: Schmitz
authors: Frans J J
authors: FJ
authors: de Kanter
authors: Alexander
authors: A
authors: Dömling
authors: Marinus B
authors: MB
authors: Groen
authors: Romano V A
authors: RV
authors: Orru
mesh_terms: D000478:Alkylation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D008745:Methylation; D008872:Microwaves; D010084:Oxidation-Reduction; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D010879:Piperazines; C482203:nutlin 1; C017424:2-imidazoline