title: Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
abstract: OBJECTIVE
  Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP-420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM.
  
  
  METHODS
  We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60.2 +/- 11.3 years, body mass index (BMI) 24.1 +/- 3.9) whose overnight fasting sera were available. Serum resistin was measured using ELISA.
  
  
  RESULTS
  Serum resistin was higher in subjects with either obesity (P = 0.041), low HDL (P = 0.004), high triglycerides (TG) (P = 0.019), hypertension (HT) (P = 0.001) or atherosclerosis (P = 0.012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high-sensitivity C-reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0.008), TG (P = 0.041), HT (P = 0.031) and hsCRP (P = 0.004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0.001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings.
  
  
  CONCLUSIONS
  Serum resistin was positively correlated with the accumulation of MetS factors in T2DM.
authors: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan. harosawa@m.ehime-u.ac.jp
authors: Haruhiko
authors: H
authors: Osawa
authors: Masaaki
authors: M
authors: Ochi
authors: Yasuharu
authors: Y
authors: Tabara
authors: Kenichi
authors: K
authors: Kato
authors: Junko
authors: J
authors: Yamauchi
authors: Yasunori
authors: Y
authors: Takata
authors: Wataru
authors: W
authors: Nishida
authors: Hiroshi
authors: H
authors: Onuma
authors: Ikki
authors: I
authors: Shimizu
authors: Yasuhisa
authors: Y
authors: Fujii
authors: Tetsuro
authors: T
authors: Miki
authors: Jun
authors: J
authors: Ohashi
authors: Hideichi
authors: H
authors: Makino
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004198:Disease Susceptibility / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
chemical_list: D008055:Lipids; C499624:RETN protein, human; D052243:Resistin