A biomimetic approach to some specifically functionalized cyclic terpenoids.
The paper relates on the current advancements in the synthesis of complex cyclic terpenoids by superacidic induced cyclization of open chain precursors. It is shown that functional groups disposal in the initial substrate strongly influences the reaction outcome. Possible variations of the investigated compound structures include particularly alpha-functionalization and alpha,omega-bifunctionalization. This approach allowed a selective initiation of cyclization sequence from an internal double bond or suspending the ring closure cascade to partially cyclized compounds. The reported synthetic schemes are attempts to mimic the biogenetical processes postulated in the living systems.
Kulciţki
Veaceslav
V
Institutul de Chimie al ASM, Chişinău, Republica Moldova. kulcitki@yahoo.com
D032701:Biomimetics / Q000379:methods* / Q000639:trends; D003500:Cyclization; D018716:Molecular Mimicry; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
D013729:Terpenes