title: Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation.
abstract: OBJECTIVE
  The objective of our study was to clarify the sequential changes of arterial blood supply during the development of hepatocellular carcinoma (HCC) with an emphasis on its late stage.
  
  
  METHODS
  Sixty HCC nodules were confirmed at pathology in 59 patients who had undergone CT hepatic arteriography and CT during arterioportography (CTAP). Lesions were classified into one of the four groups: group 1, nodules that appeared to show preserved portal perfusion on CTAP and showed hypo- or isoattenuation on CT hepatic arteriography; group 2, very hyperattenuating on CT hepatic arteriography; group 3, hyperattenuating on CT hepatic arteriography; and group 4, hypo- or isoattenuating on CT hepatic arteriography. Groups 2, 3, and 4 showed the portal perfusion defect on CTAP. These hemodynamic patterns were compared among different histologic grades. We also examined the number of unpaired arteries and the Ki-67 labeling index of the tumor pathologically.
  
  
  RESULTS
  The numbers of lesions in each group were as follows for groups 1, 2, 3, and 4, respectively: 17, one, two, and 0 well-differentiated HCCs; 0, 10, nine, and one moderately differentiated HCC; and 0, three, 12, and five poorly differentiated HCCs. The lesions showed significantly different hemodynamic patterns among different histologic grades (Cramer's V = 0.6919, p < 0.0001). The number of unpaired arteries showed a strong correlation with Ki-67 labeling index in well-differentiated HCC and moderately differentiated HCC (rho = 0.673, p < 0.0001) and a moderate inverse correlation with Ki-67 labeling index in poorly differentiated HCC (rho = -0.540, p = 0.0185).
  
  
  CONCLUSIONS
  In the late stage of HCC development, the arterial blood supply significantly decreases as the histologic grade progresses.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors: Yoshiki
authors: Y
authors: Asayama
authors: Kengo
authors: K
authors: Yoshimitsu
authors: Yunosuke
authors: Y
authors: Nishihara
authors: Hiroyuki
authors: H
authors: Irie
authors: Shinichi
authors: S
authors: Aishima
authors: Akinobu
authors: A
authors: Taketomi
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000368:Aged; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology*; D002454:Cell Differentiation; D006439:Hemodynamics; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed