Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus.
The aim of the present work was to identify the characteristics of the control of apoptosis in neurosecretory centers of aged (18 months) mice on exposure to the immunomodulator interferon-alpha (IA) in comparison with young (two months) mice. Age-related activation of apoptosis in the supraoptic (SON) and paraventricular (PVN) nuclei was found to be mediated by different pathways and could result from changes in the ratio of synthesis of pro-(Bax) and antiapoptotic (Mcl-1, Bcl-2) molecules. In addition, the apoptosis signal cascade in young mice treated with IA was identical in both nuclei, while in aged mice there were differences between the SON and the PVN.
Bazhanova
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ED
Laboratory for Comparative Somnology and Neuroendocrinology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
Molodtsov
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VN
Pavlov
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KI
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D016898:Interferon-alpha / Q000502:physiology; D008297:Male; D051379:Mice; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins / Q000378:metabolism; D009490:Neurosecretory Systems / Q000166:cytology / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D018709:Statistics, Nonparametric; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; C494827:Bax protein, mouse; D016898:Interferon-alpha; C579094:Mcl1 protein, mouse; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein