Inducing autophagy harmlessly.
An important role of autophagy in the clearance of misfolded proteins in neurons has been demonstrated. The challenge now is to see if we can develop small molecules that can induce autophagy without causing cellular damage.
Yuan
Junying
J
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. jyuan@hms.harvard.edu
D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000627:therapeutic use; D019610:Cytoprotection / Q000187:drug effects*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D054852:Small Molecule Libraries
D002491:Central Nervous System Agents; D054852:Small Molecule Libraries