title: Combination antiretroviral therapy failure and HIV super-infection.
abstract: In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection.
authors: HIV Monitoring Foundation, Academic Medical Centre, University of Amsterdam, the Netherlands.
authors: Daniela
authors: D
authors: Bezemer
authors: Ard
authors: A
authors: van Sighem
authors: Frank
authors: F
authors: de Wolf
authors: Marion
authors: M
authors: Cornelissen
authors: Antoinette C
authors: AC
authors: van der Kuyl
authors: Suzanne
authors: S
authors: Jurriaans
authors: Lia
authors: L
authors: van der Hoek
authors: Maria
authors: M
authors: Prins
authors: Roel A
authors: RA
authors: Coutinho
authors: Vladimir V
authors: VV
authors: Lukashov
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D019143:Evolution, Molecular; D005260:Female; D015751:Genes, pol / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D009426:Netherlands; D017421:Sequence Analysis; D015163:Superinfection / Q000821:virology*; D017211:Treatment Failure; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
chemical_list: D044966:Anti-Retroviral Agents; D054302:pol Gene Products, Human Immunodeficiency Virus