title: Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
abstract: We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
authors: Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA. tk.sinha@vanderbilt.edu
authors: Tuhin K
authors: TK
authors: Sinha
authors: Sheerin
authors: S
authors: Khatib-Shahidi
authors: Thomas E
authors: TE
authors: Yankeelov
authors: Khubaib
authors: K
authors: Mapara
authors: Moneeb
authors: M
authors: Ehtesham
authors: D Shannon
authors: DS
authors: Cornett
authors: Benoit M
authors: BM
authors: Dawant
authors: Richard M
authors: RM
authors: Caprioli
authors: John C
authors: JC
authors: Gore
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D010449:Peptide Mapping / Q000379:methods*; D020543:Proteome / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D018511:Systems Integration; D014018:Tissue Distribution
chemical_list: D020543:Proteome