Mild amidation of aldehydes with amines mediated by lanthanide catalysts.
Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm approximately Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
Seo
SungYong
S
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
Marks
Tobin J
TJ
D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D015394:Molecular Structure
D000447:Aldehydes; D000577:Amides; D028581:Lanthanoid Series Elements