Synthetic zeolites as a new tool for drug delivery.
Synthetic zeolites were studied in order to investigate their ability to encapsulate and to release drugs. In particular, a zeolite X and a zeolitic product obtained from a cocrystallization of zeolite X and zeolite A were examined. These materials were characterized by chemical analyses (ICP-AES), X-ray diffraction, nitrogen adsorption isotherm, scanning electron microscopy, laser diffraction, and infrared spectroscopy. Since ketoprofen was chosen as a model drug for the formulation of controlled-release dosage forms, it was encapsulated into these two types of synthetic zeolites by a soaking procedure. Drug-loaded matrices were then characterized for entrapped drug amount and thermogravimetric behavior. In both types of activated zeolites, the total amount of ketoprofen (800 mg) was encapsulated in 2 g of matrix. By using HPLC measurements, ketoprofen release studies were done at different pH conditions so as to mimick gastrointestinal fluids. The absence of release in acid conditions and a double phased release, at two different pH values (5 and 6.8), suggest that after activation these materials offer good potential for a modified release delivery system of ketoprofen.
Rimoli
Maria G
MG
Department of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, Federico II University of Naples, via Domenico Montesano 49, 80131 Naples, Italy.
Rabaioli
Maria R
MR
Melisi
Daniela
D
Curcio
Annalisa
A
Mondello
Sandro
S
Mirabelli
Rosella
R
Abignente
Enrico
E
D000327:Adsorption; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D009584:Nitrogen / Q000737:chemistry; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D017641:Zeolites / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017641:Zeolites; D007660:Ketoprofen; D009584:Nitrogen