[Current status and perspective of hepatitis C virus models].
Lack of proper study models has brought difficulties in the study of the mechanism of viral infection, life cycle and pathogenic mechanism of hepatitis C virus (HCV) and also become the major obstacles in development of efficient vaccine and new drugs for hepatitis C. In recent years, the establishment of robust HCV cell culture infection system and HCV transgenic animal provide powerful tools for the analysis of host virus interactions, which facilitate the discovery of antiviral drugs and vaccines for this important human pathogen.
Zhao
Si-hai
SH
Department of Microbiology and Immunology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Chu
Yong-lie
YL
Xun
Meng
M
D000818:Animals; D030801:Animals, Genetically Modified / Q000821:virology; D004195:Disease Models, Animal; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000821:virology*; D051379:Mice; D008822:Mice, Transgenic / Q000821:virology*