title: MRI and hybrid PET/CT for monitoring tumour metastasis in a metastatic breast cancer model in rabbit.
abstract: OBJECTIVE
  To study tumour growth and metastasis in a rabbit metastatic breast cancer (MBC) model and find the most sensitive screening modality in monitoring tumour metastasis.
  
  
  METHODS
  The MBC model was established by injecting a VX2 tumour mass suspension into the mammary glands of 23 rabbits and was monitored by using physical examination, X-ray, MRI and hybrid PET/CT.
  
  
  RESULTS
  Of all 23 rabbits, axillary lymph node metastasis was detected in 21 (91%) at day 33 after tumour inoculation, mediastinal node metastasis in five (22%) at day 42, abdominal node metastasis in two (9%) at day 48, lung metastasis in six (26%) at day 39, liver metastasis in three (13%) at day 48, and lumbar spine metastasis in one (4%) at day 51. Tumour invasion of pleura was found in one, stomach wall in one, and pleura and stomach concurrently in one rabbit. Sensitivity for detection of lymph node metastases was 78.6% (22/28) and 67.9% (19/28) with MRI and PET/CT, respectively; and sensitivity for detection of metastases in distant organs was 85.7% (12/14) and 71.4% (10/14), respectively.
  
  
  CONCLUSIONS
  The MBC model used here exhibits fast tumour growth and extensive metastasis in a relatively short period. Its metastatic pattern is quite similar to that of human MBC and hence could be potentially used as a model for testing imaging modalities and translational research, e.g., MBC management. MRI is superior to PET/CT in monitoring tumour metastasis.
authors: Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Ling
authors: L
authors: Wang
authors: Qing
authors: Q
authors: Yao
authors: Jing
authors: J
authors: Wang
authors: Guangquan
authors: G
authors: Wei
authors: Guoquan
authors: G
authors: Li
authors: Dong
authors: D
authors: Li
authors: Rui
authors: R
authors: Ling
authors: Jianghao
authors: J
authors: Chen
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D045744:Cell Line, Tumor; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008159:Lumbar Vertebrae / Q000473:pathology; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis* / Q000473:pathology*; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D011817:Rabbits; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*