title: KEGG for linking genomes to life and the environment.
abstract: KEGG (http://www.genome.jp/kegg/) is a database of biological systems that integrates genomic, chemical and systemic functional information. KEGG provides a reference knowledge base for linking genomes to life through the process of PATHWAY mapping, which is to map, for example, a genomic or transcriptomic content of genes to KEGG reference pathways to infer systemic behaviors of the cell or the organism. In addition, KEGG provides a reference knowledge base for linking genomes to the environment, such as for the analysis of drug-target relationships, through the process of BRITE mapping. KEGG BRITE is an ontology database representing functional hierarchies of various biological objects, including molecules, cells, organisms, diseases and drugs, as well as relationships among them. KEGG PATHWAY is now supplemented with a new global map of metabolic pathways, which is essentially a combined map of about 120 existing pathway maps. In addition, smaller pathway modules are defined and stored in KEGG MODULE that also contains other functional units and complexes. The KEGG resource is being expanded to suit the needs for practical applications. KEGG DRUG contains all approved drugs in the US and Japan, and KEGG DISEASE is a new database linking disease genes, pathways, drugs and diagnostic markers.
authors: Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.
authors: Minoru
authors: M
authors: Kanehisa
authors: Michihiro
authors: M
authors: Araki
authors: Susumu
authors: S
authors: Goto
authors: Masahiro
authors: M
authors: Hattori
authors: Mika
authors: M
authors: Hirakawa
authors: Masumi
authors: M
authors: Itoh
authors: Toshiaki
authors: T
authors: Katayama
authors: Shuichi
authors: S
authors: Kawashima
authors: Shujiro
authors: S
authors: Okuda
authors: Toshiaki
authors: T
authors: Tokimatsu
authors: Yoshihiro
authors: Y
authors: Yamanishi
mesh_terms: D016208:Databases, Factual; D004194:Disease; D023281:Genomics; D006801:Humans; D020407:Internet; D053858:Metabolic Networks and Pathways; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry; D049490:Systems Biology; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D004364:Pharmaceutical Preparations