Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs.
Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.
Williams
Jonathan P
JP
Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK. j.p.williams@warwick.ac.uk
Scrivens
James H
JH
D000082:Acetaminophen / Q000032:analysis; D000700:Analgesics / Q000032:analysis; D000891:Anti-Infective Agents, Local / Q000032:analysis; D001566:Benzocaine / Q000032:analysis; D002110:Caffeine / Q000032:analysis; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000032:analysis; D003061:Codeine / Q000031:analogs & derivatives / Q000032:analysis; D003802:Dentifrices / Q000032:analysis; D004338:Drug Combinations; D005782:Gels / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011092:Polyethylene Glycols / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D000700:Analgesics; D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D004338:Drug Combinations; D005782:Gels; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D002110:Caffeine; D011092:Polyethylene Glycols; C034242:solpadeine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D001566:Benzocaine; D003061:Codeine