Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.
Caplan
Avrom J
AJ
Ma'ayan
Avi
A
Willis
Ian M
IM
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
C513270:CDC37 protein, S cerevisiae; D018797:Cell Cycle Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D010770:Phosphotransferases