title: Histogenetic processes leading to the laminated neocortex: migration is only a part of the story.
abstract: The principal events of neocortical histogenesis were anticipated by work published prior to the 20th century. These were neuronal proliferation and migration and the complex events of cortical pattern formation leading to a laminated architecture where each layer is dominated by a principal neuronal class. Work that has followed has extended the knowledge of the workings of the proliferative epithelium, cellular mechanisms of migration and events through which cells are winnowed and then differentiate once their postmigratory positions are established. Work yet ahead will emphasize mechanisms that coordinate the molecular events that integrate proliferation and cell class specification in relation to the final neocortical neural system map.
authors: Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA. caviness@helix.mgh.harvard.edu
authors: V S
authors: VS
authors: Caviness
authors: P G
authors: PG
authors: Bhide
authors: R S
authors: RS
authors: Nowakowski
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000235:genetics; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D019579:Neocortex / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D009474:Neurons / Q000145:classification / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics