[Research on mechanism underlying bone damage in myeloma--review].
Multiple myeloma (MM) is a B cell malignancy characterized by enhanced bone loss that commonly associated with diffuse osteopenia, focal lytic lesions, pathologic fractures, and bone pain. The key mechanism of bone damage in myeloma is the abnormal regulation in bone metastasis, with increased osteoclast function and decreased osteoblast activity. This article reviewed the factors implicated, such as receptor activator of nuclear factor-kappaB (RANK), receptor activator of nuclear factor-kappaB ligand (RANKL), osteoprotegerin (OPG), macrophage inflammatory protein-1alpha (MIP-1alpha), SDF-1 and Wnt pathway. Further understanding of the regulation system of bone homeostasis helps to offer possible targets for future therapy.
Zhou
Li-Li
LL
Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China. houjian@medmail.com.cn
D001847:Bone Diseases / Q000209:etiology*; D001842:Bone and Bones / Q000473:pathology*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology