Primary biliary cirrhosis in female subjects with sicca-associated antibodies.
The aim of this study is to clarify the time course of primary biliary cirrhosis (PBC) in subjects possessing anticentromere antibodies (ACA), anti-Ro, and/or anti-La antibodies, and who used alkaline phosphatase (ALP) as a serological marker for PBC. Female subjects (n = 165), who had at least one of ACA, anti-Ro, and/or anti-La, were enrolled in this study. Groups A (ACA alone, n = 44), B (anti-Ro alone, n = 54), E (anti-Ro and anti-La, n = 52), and DFG (ACA with anti-Ro and/or anti-La, n = 14) were analyzed. Healthy females (n = 65) were used as a control. The frequencies of the PBC in groups A (13.6%) and DFG (14.3%) were higher than those in groups B (1.9%) and E (0.0%). The ALP levels increased with age in groups A and DFG and slightly increased with age in groups B and C, and the control group. After correcting for age by analysis of covariance, a comparison of ALP levels among the groups not having anti-M(2) was as follows: group A falling dots group DFG > group B falling dots group E falling dots the control group. The subjects with ACA might thus have PBC more frequently than either those with anti-Ro and/or anti-La, or the control subjects.
Takada
Kunio
K
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan. dr20021@ndmc.ac.jp
Suzuki
Kimihiro
K
Matsumoto
Mitsuyo
M
Okada
Makoto
M
Nakanishi
Takashi
T
Horikoshi
Hideyuki
H
Higuchi
Tomoaki
T
Ohsuzu
Fumitaka
F
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002503:Centromere / Q000276:immunology*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology*; D008875:Middle Aged; D012261:Ribonucleoproteins / Q000097:blood / Q000276:immunology*; D000097585:SS-B Antigen
D000469:Alkaline Phosphatase; D000974:Antibodies, Antinuclear; D001324:Autoantigens; D015415:Biomarkers; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; C035356:SS-A antibodies