Quetiapine-induced leucopenia and thrombocytopenia.
Antipsychotic drugs can cause neutropenia, which can progress to life-threatening agranulocytosis if drug therapy is not interrupted. The newer atypical antipsychotics are reputedly without adverse hematological effects. Quetiapine is a recently introduced atypical antipsychotic. It is a dibenzothiazepine derivative and shows similarities with clozapine in that it is characterized by high 5-HT(2)-relative-to-DA(2) receptor affinity. Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.
Shankar
B Ravi
BR
Krishna Nursing Home, Tamil Nadu, India. drravishankarbalu@gmail.com
D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D018692:Antimanic Agents / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D003006:Clopenthixol / Q000008:administration & dosage / Q000031:analogs & derivatives; D003987:Dibenzothiazepines / Q000009:adverse effects*; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced* / Q000175:diagnosis; D008140:Lorazepam / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000008:administration & dosage; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D014635:Valproic Acid
D014151:Anti-Anxiety Agents; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; C060342:clopenthixol acetate ester; D000069348:Quetiapine Fumarate; D014635:Valproic Acid; D003006:Clopenthixol; D018967:Risperidone; D008140:Lorazepam