Recollections on thrombin generation.
Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.
Hemker
H Coenraad
HC
Synapse BV, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands. hc.hemker@thrombin.com
D000925:Anticoagulants / Q000266:history / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology; D006405:Hematology / Q000266:history*; D006487:Hemostasis / Q000502:physiology; D006495:Heparin, Low-Molecular-Weight / Q000266:history / Q000494:pharmacology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009426:Netherlands; D011516:Prothrombin / Q000378:metabolism; D013917:Thrombin / Q000096:biosynthesis / Q000266:history*
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D011516:Prothrombin; D013917:Thrombin