title: A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines.
abstract: Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in good yield. The reaction mechanism is believed to involve a free-radical sequence resulting in an imino alcohol subsequently reduced to product.
authors: Department of Science and Mathematics, Johnson C. Smith University, Charlotte, NC 28216, USA.
authors: Henry F
authors: HF
authors: Russell
authors: John B
authors: JB
authors: Bremner
authors: Jennifer
authors: J
authors: Bushelle-Edghill
authors: Melissa R
authors: MR
authors: Lewis
authors: Stacey R
authors: SR
authors: Thomas
authors: Floyd
authors: F
authors: Bates