Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss.
We previously reported a close relationship between serum immunoglobulin (Ig)E and anti-SSA antibody levels in mothers with foetal loss. Here, we investigated the existence of IgE class anti-SSA antibodies (IgE anti-SSA antibody) and the relationship of such antibodies with foetal loss. Serum samples from 24 women who were positive for IgG class anti-SSA antibody (IgG anti-SSA antibody) were examined for IgE anti-SSA antibody by enzyme-linked immunosorbent assay (ELISA). Then, a retrospective analysis of the relationship between the IgE anti-SSA antibody positivity and the frequency of foetal loss was performed. Using our ELISA system, IgE anti-SSA antibodies were detected in the serum samples, and the frequency of foetal loss was increased among the mothers with higher IgE anti-SSA antibody titers. Our results indicate that IgE anti-SSA antibodies may be a useful marker for the risk of foetal loss in mothers with anti-SSA antibodies.
Sekigawa
Iwao
I
Department of Internal Medicine, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-shi, Chiba 279-0021, Japan. sekigawa@juntendo-urayasu.jp
Kaneda
Kazuhiko
K
Kaneko
Hiroshi
H
Takasaki
Yoshinari
Y
Takamori
Kenji
K
Ogawa
Hideoki
H
D000022:Abortion, Spontaneous / Q000097:blood* / Q000209:etiology; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy
D000974:Antibodies, Antinuclear; D015415:Biomarkers; C035356:SS-A antibodies; D007073:Immunoglobulin E