title: Assessment of precision and reproducibility of a new myograph.
abstract: BACKGROUND
  The physiological characteristics of muscle activity and the assessment of muscle strength represent important diagnostic information. There are many devices that measure muscle force in humans, but some require voluntary contractions, which are difficult to assess in weak or unconscious patients who are unable to complete a full range of voluntary force assessment tasks. Other devices, which obtain standard muscle contractions by electric stimulations, do not have the technology required to induce and measure reproducible valid contractions at the optimum muscle length.
  
  
  METHODS
  In our study we used a newly developed diagnostic device which measures accurately the reproducibility and time-changed-variability of the muscle force in an individual muscle. A total of 500 in-vivo measurements of supra-maximal isometric single twitch contractions were carried out on the musculus adductor pollicis of 5 test subjects over 10 sessions, with ten repetitions per session. The same protocol was performed on 405 test subjects with two repetitions each to determine a reference-interval on healthy subjects.
  
  
  RESULTS
  Using our test setting, we found a high reproducibility of the muscle contractions of each test subject. The precision of the measurements performed with our device was 98.74%. Only two consecutive measurements are needed in order to assess a real, representative individual value of muscle force. The mean value of the force of contraction was 9.51 N and the 95% reference interval was 4.77-14.25 N.
  
  
  CONCLUSIONS
  The new myograph is a highly reliable measuring device with which the adductor pollicis can be investigated at the optimum length. It has the potential to become a reliable and valid tool for diagnostic in the clinical setting and for monitoring neuromuscular diseases.
authors: Department of Anesthesiology, Hannover Medical School, Carl-Neuberg-Str, 1, D-30625 Hannover, Germany. Rahe-Meyer.Niels@MH-Hannover.de
authors: Niels
authors: N
authors: Rahe-Meyer
authors: Michael
authors: M
authors: Winterhalter
authors: Aminul I
authors: AI
authors: Ahmed
authors: Christian
authors: C
authors: Weilbach
authors: Matthias
authors: M
authors: Gross
authors: Siegfried
authors: S
authors: Piepenbrock
authors: Matthias
authors: M
authors: Pawlak
mesh_terms: D000328:Adult; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D009213:Myography / Q000295:instrumentation*; D015203:Reproducibility of Results; D013933:Thumb / Q000502:physiology