title: Facially selective and regioselective carbometalation of cyclopropenes by aryl Grignard reagents.
abstract: Described is a Cu-catalyzed methodology for adding aryl Grignard reagents to 3-hydroxymethylcyclopropene derivatives with high regio- and diastereoselectivity. The cyclopropylmetals can be trapped with a variety of electrophiles to generate highly substituted cyclopropanes.
authors: Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
authors: Ni
authors: N
authors: Yan
authors: Xiaozhong
authors: X
authors: Liu
authors: Joseph M
authors: JM
authors: Fox
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C527429:3-hydroxymethylcyclopropene; D003521:Cyclopropanes; D007454:Iodides; D009942:Organometallic Compounds; D003300:Copper; C073870:cuprous iodide