The Generation R Study Biobank: a resource for epidemiological studies in children and their parents.
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
Jaddoe
Vincent W V
VW
The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl
Bakker
Rachel
R
van Duijn
Cock M
CM
van der Heijden
Albert J
AJ
Lindemans
Jan
J
Mackenbach
Johan P
JP
Moll
Henriëtte A
HA
Steegers
Eric A P
EA
Tiemeier
Henning
H
Uitterlinden
Andre G
AG
Verhulst
Frank C
FC
Hofman
Albert
A
D000328:Adult; D018070:Biological Specimen Banks; D015331:Cohort Studies; D004247:DNA / Q000032:analysis; D016208:Databases, Factual; D004777:Environment; D005260:Female; D047109:Fetal Development / Q000235:genetics / Q000502:physiology*; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics; D006130:Growth Disorders / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006803:Human Development; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011446:Prospective Studies
D004247:DNA