Analysis of pressure-driven air bubble elimination in a microfluidic device.
We report an analysis of pressure-driven bubble elimination for a gas-permeable microfluidic device. In this study, we described bubble elimination in a microfluidic device employing a gas permeation model and calculated the removal efficiency of bubbles. The correction factor for the simplified model was estimated with respect to the applied pressure. Based on the established model, the required time to remove a trapped bubble with a certain area was shown to be within an error of 11.58% by comparison with experimental results. Exploiting the model equation, we were able to completely remove the air bubbles appearing during the process of filling a microfluidic device with an aqueous solution.
Kang
Joo H
JH
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Korea.
Kim
Yu Chang
YC
Park
Je-Kyun
JK
D000388:Air / Q000032:analysis*; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D044085:Microfluidics / Q000295:instrumentation*; D011312:Pressure; D012828:Silicones / Q000737:chemistry; D012996:Solutions
D004129:Dimethylpolysiloxanes; D012828:Silicones; D012996:Solutions; C013830:baysilon