title: Randomized, controlled, blinded trial of Tissucol/Tisseel for mesh fixation in patients undergoing Lichtenstein technique for primary inguinal hernia repair: rationale and study design of the TIMELI trial.
abstract: BACKGROUND
  Complications associated with sutured mesh fixation following open groin hernia repair have prompted surgeons to evaluate methods of atraumatic fixation such as the use of human fibrin glue. Small trials with Tissucol/Tisseel fibrin glue (Baxter Healthcare, Deerfield, IL, USA) have shown promising results that warrant further investigation.
  
  
  METHODS
  TIMELI (Tissucol/Tisseel for MEsh fixation in LIchtenstein hernia repair) is an international, controlled, randomized, patient- and evaluator-blinded study that is comparing mesh fixation with Tissucol or sutures in patients with inguinal hernia. The primary endpoint evaluates the incidence of disabling complications (chronic pain and/or numbness and/or groin discomfort) at 12 months post-surgery.
  
  
  RESULTS
  Patient enrolment started in February 2006 and ended on 19 April 2007, with a total of 325 patients recruited. Initial results are expected in early 2008.
  
  
  CONCLUSIONS
  TIMELI is a major international trial that will provide important information on the efficacy and safety of Tissucol, compared with sutures, for mesh fixation in patients undergoing Lichtenstein technique for primary inguinal hernia repair.
authors: University of Insubria di Varese, Varese, Italy. Giampiero.campanelli@multimedica.it
authors: G
authors: G
authors: Campanelli
authors: G
authors: G
authors: Champault
authors: M Hidalgo
authors: MH
authors: Pascual
authors: A
authors: A
authors: Hoeferlin
authors: A
authors: A
authors: Kingsnorth
authors: J
authors: J
authors: Rosenberg
authors: M
authors: M
authors: Miserez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012107:Research Design; D018709:Statistics, Nonparametric; D013526:Surgical Mesh; D013536:Suture Techniques; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive