title: Antimycobacterial Activity and Mechanism of Action of NAS-91.
abstract: The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
authors: Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS, UMR 5235, case 107, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France.
authors: Paul
authors: P
authors: Gratraud
authors: Namita
authors: N
authors: Surolia
authors: Gurdyal S
authors: GS
authors: Besra
authors: Avadhesha
authors: A
authors: Surolia
authors: Laurent
authors: L
authors: Kremer
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D002474:Cell-Free System; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D054889:Fatty Acid Synthase, Type II / Q000037:antagonists & inhibitors; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000187:drug effects* / Q000254:growth & development*; D009171:Mycolic Acids / Q000378:metabolism*; D019301:Oleic Acid / Q000096:biosynthesis*; D013230:Stearoyl-CoA Desaturase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D003470:Culture Media; D004791:Enzyme Inhibitors; D009171:Mycolic Acids; D019301:Oleic Acid; D013230:Stearoyl-CoA Desaturase; D054889:Fatty Acid Synthase, Type II