title: The peroxiredoxin repair proteins.
abstract: Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry.
authors: Center for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
authors: Thomas J
authors: TJ
authors: Jönsson
authors: W Todd
authors: WT
authors: Lowther
mesh_terms: D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology*; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000737:chemistry / Q000378:metabolism*; D010545:Peroxides / Q000737:chemistry / Q000378:metabolism; D054464:Peroxiredoxins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D006360:Heat-Shock Proteins; D010545:Peroxides; D054464:Peroxiredoxins; D050862:Oxidoreductases Acting on Sulfur Group Donors; D003545:Cysteine; C013461:cysteine sulfinic acid