title: Evaluating coupling procedures for synthesis of lna-Peptide conjugates.
abstract: As initial studies of block coupling of peptides with C-terminal glycines, we have evaluated of coupling of glycine building blocks under various conditions to a preassembled solid support bound LNA-fragment. Potentially competing side reaction have been studied and we have worked out a procedure for trifluoroacetyl protection of peptides.
authors: Department of Biosciences and Nutrition, Karolinska Institutet, S-14157 Huddinge, Sweden.
authors: Peter
authors: P
authors: Steunenberg
authors: Hans
authors: H
authors: Leijonmarck
authors: Mathias G
authors: MG
authors: Svahn
authors: C I Edvard
authors: CI
authors: Smith
authors: Roger
authors: R
authors: Strömberg
mesh_terms: D001483:Base Sequence; D005998:Glycine / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; D010455:Peptides; C477371:locked nucleic acid; D011392:Proline; D005998:Glycine