[Study on the correlation between hypertension and the indexes of vascular endothelial function among people living in the community].
OBJECTIVE
To study the features of hypertension and vessel endothelium functional parameter in people living at the community level as well as the risk factors of hypertension. Differences of angiotensin II (Ang II ), prostacyclin (PGI2) and nitric oxide (NO) among normal group and three hypertension groups were also studied.


METHODS
By cluster sampling, 1134 adult Han people were selected from the residential communities. Medical history was documented and measurements of body height, body weight, waist circumference, hip circumference and blood pressure were performed. Serum NO levels were determined by cadmium reduction method while plasma Ang II and PGI2 concentration were determined by radioimmunoassay. SPSS 13.0 was used for data analysis.


RESULTS
The total ratio of hypertension from people living at the community was 44.5%, with the standardized prevalence of hypertension as 15.3%. With the increase of age, the prevalence of hypertension also increased. Overweight and obesity seemed to be independent risk factors for hypertension. History of smoking and drinking and gender did not enter the logistic equation for hypertension. The amount of plasma Ang II concentration of the three hypertension groups was significantly lower than that in the normal group while the lowest group appeared to from the one that hypertension was under control. The NO and PGI2 levels of the two groups whose hypertension had been known were significantly higher than in the normal group while the difference between the group whose hypertension had not been measured and the normal group was not found.


CONCLUSIONS
The prevalence of hypertension had been increasing. Control of body weight seemed to be a useful way for prevention of hypertension. We assumed that the negative feedback regulation of renin-angiotonin-aldosterone system in hypertension patient still existed which called for the research on the mechanism of hypertension.
Huang
Hai-Wei
HW
Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Tan
Shuang-Quan
SQ
Fu
Xian
X
Peng
Dan-Xin
DX
Liu
Xiu-Qin
XQ
Lin
Rui-Jin
RJ
Wu
Shu-Heng
SH
Huang
Jia-Xing
JX
D000328:Adult; D000367:Age Factors; D000368:Aged; D000804:Angiotensin II / Q000032:analysis; D016000:Cluster Analysis; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors
D000804:Angiotensin II; D009569:Nitric Oxide; D011464:Epoprostenol