title: Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas.
abstract: OBJECTIVE
  Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas encompasses a spectrum of neoplasms with both morphological and immunohistochemical variations of mucin glycoproteins. Recently, a consensus nomenclature and criteria were histologically defined for classifying these variants of IPMNs into gastric, intestinal, pancreatobiliary, and oncocytic types. The purpose of this study was to determine associations between the histological types and clinicopathological features in patients with IPMN.
  
  
  METHODS
  Sixty-one patients with IPMN operated upon at Tohoku University Hospital between 1988 and 2006 were retrospectively analyzed.
  
  
  RESULTS
  Our series included 27 gastric-, 29 intestinal-, 4 pancreatobiliary-, and 1 oncocytic-type IPMNs. Statistically, the types of IPMN were significantly associated with the histological diagnoses, macroscopic types, and survival of the patients. Characteristically, the gastric-type IPMNs were likely to be diagnosed as benign, to be confined to branch ducts, and to have fair prognoses. On the other hand, the intestinal-type IPMNs were likely to be diagnosed as malignant, occupy the main duct, and have poor prognoses. Because of the small number of pancreatobiliary-type IPMNs and only 1 case of oncocytic-type IPMN, we were unable to determine any of their clinicopathological characteristics in our series.
  
  
  CONCLUSIONS
  Evaluation of the histological types of IPMN may help to predict the clinical course of patients with IPMN and to design improved clinical management for these patients.
authors: Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Masaharu
authors: M
authors: Ishida
authors: Shinichi
authors: S
authors: Egawa
authors: Takeshi
authors: T
authors: Aoki
authors: Naoaki
authors: N
authors: Sakata
authors: Yukio
authors: Y
authors: Mikami
authors: Fuyuhiko
authors: F
authors: Motoi
authors: Tadayoshi
authors: T
authors: Abe
authors: Shoji
authors: S
authors: Fukuyama
authors: Makoto
authors: M
authors: Sunamura
authors: Michiaki
authors: M
authors: Unno
authors: Takuya
authors: T
authors: Moriya
authors: Akira
authors: A
authors: Horii
authors: Toru
authors: T
authors: Furukawa
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D000236:Adenoma / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D018396:Mucin-1 / Q000032:analysis; D055262:Mucin-2; D009077:Mucins / Q000032:analysis; D009361:Neoplasm Invasiveness; D010183:Pancreatic Ducts / Q000737:chemistry / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: C060192:MUC1 protein, human; C524625:MUC2 protein, human; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D018396:Mucin-1; D055262:Mucin-2; D009077:Mucins