title: Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents.
abstract: BACKGROUND
  Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease.
  
  
  OBJECTIVE
  Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile.
  
  
  METHODS
  181 obese adolescents including 113 girls (16.58+/-1.56 years) and 68 boys (16.87+/-1.62 years) were evaluated.
  
  
  METHODS
  The inclusion criteria were obesity and post-pubertal stage of Tanner. Visceral fat of obese adolescents was distributed in quartiles after ultrasound nonalcoholic fatty liver disease diagnosis.
  
  
  RESULTS
  Nonalcoholic fatty liver disease prevalence was 45.30%. It was observed that 62.07% and 76.47% of girls and boys with nonalcoholic fatty liver disease were found in the 4th quartile. In a multivariate logistic analysis it was observed that only visceral fat remained statistically significant, every 1cm increase in visceral fat was associated with a 1.97 fold (95% CI 1.06-3.66) in boys and 2.08 fold (95% CI 1.38-3.13) in girls increased risk to develop nonalcoholic fatty liver disease. Indeed it was verified a positive correlation between visceral fat, body mass index, insulin levels, homeostasis model assessment insulin resistance index and steatosis degree.
  
  
  CONCLUSIONS
  Our findings suggested that the expansion of visceral fat was a determinant factor to increase nonalcoholic fatty liver disease prevalence and the visceral fat measured by ultrasound might be a good predictor to identify risk for nonalcoholic fatty liver disease in obese adolescents. It was confirmed by a stronger correlation between visceral fat and body mass index.
authors: Post Graduate Program of Nutrition, Federal University of São Paulo, Paulista Medicine School, UNIFESP-EPM, Brazil. ana.damaso@unifesp.br <ana.damaso@unifesp.br>
authors: A R
authors: AR
authors: Dâmaso
authors: W L
authors: WL
authors: do Prado
authors: A
authors: A
authors: de Piano
authors: L
authors: L
authors: Tock
authors: D A
authors: DA
authors: Caranti
authors: M C
authors: MC
authors: Lofrano
authors: J
authors: J
authors: Carnier
authors: D J M
authors: DJ
authors: Cristofalo
authors: H
authors: H
authors: Lederman
authors: S
authors: S
authors: Tufik
authors: M T
authors: MT
authors: de Mello
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000886:Anthropometry; D015992:Body Mass Index; D015897:Comorbidity; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008297:Male; D009765:Obesity / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000378:metabolism; D015995:Prevalence; D014463:Ultrasonography