Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids.
Primary and secondary alkyl amines substitute readily one of the para-methoxy substituents of tris(2,4,6-trimethoxyphenyl)methyl carbenium ion. With this rapid process, the preparation of permanently charged positive derivatives of amines, amino acids and small C-protected peptides is achieved. This is utilized here to facilitate the matrix assisted laser desorption ionization-time-of-flight (MALDI-TOF) analysis of these compounds.
Denekamp
Chagit
C
Department of Chemistry, Technion Israel Institute of Technology, Haifa, Israel. chchagit@techunix.technion.ac.il
Lacour
Jérôme
J
Laleu
Benoît
B
Rabkin
Emilia
E
D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D007477:Ions; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D055672:Static Electricity
D000588:Amines; D000596:Amino Acids; D007477:Ions; C030011:carbene; D008697:Methane