title: [A case of therapy-related acute monocytic leukemia following low-dose of etoposide treatment for hemophagocytic lymphohistiocytosis].
abstract: We report a case of therapy-related acute myeloid leukemia after low-dosed topoisomerase II inhibitor (etoposide) treatment for hemophagocytic lymphohistiocytosis (HLH). A 62-yr-old female patient had previously been treated with a HLH-94 protocol containing a low-dose of etoposide (total dose of 300 mg/m2). Thirty-one months later, the patient was admitted to the hematology department with general weakness and upper respiratory infection symptoms. Peripheral blood smear and bone marrow study revealed acute monocytic leukemia. There was no evidence of myelodysplastic syndrome, and a cytogenetic study showed no chromosomal abnormalities.
authors: Department of Laboratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors: Young Ik
authors: YI
authors: Seo
authors: Rojin
authors: R
authors: Park
authors: Tae Youn
authors: TY
authors: Choi
authors: Jeung Won
authors: JW
authors: Shin
authors: Jong Ho
authors: JH
authors: Won
authors: Hee Sook
authors: HS
authors: Park
authors: Nam Soo
authors: NS
authors: Lee
authors: Duck
authors: D
authors: Cho
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D005047:Etoposide