[Cytogenetic and molecular basis of multiple myeloma].
Multiple myeloma(MM) originating from plasma cells is characterized by complex chromosomal aberrations. The most prominent chromosomal abnormalities of MM are aneuploidy and translocations affecting the immunoglobulin heavy chain locus on chromosome 14q32. Additionally, a variety of genetic aberrations such as ras mutations have been found in MM. Because these chromosomal and genetic abnormalities are closely associated with clinical behavior including prognosis, cytogenetic findings have a great impact on planning treatment strategy. Furthermore, studies of signal transductions and mechanisms of oncogenesis in association with these abnormalities will provide targets to develop novel therapeutic agents. Here we summarize the chromosomal and genetic abnormalities of MM and their clinical implications.
Taniwaki
Masafumi
M
Department of Hematology and Oncology, Kyoto Prefectural University of Medicine.
Matsumoto
Yosuke
Y
D000782:Aneuploidy; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D009101:Multiple Myeloma / Q000235:genetics*; D009154:Mutation; D015398:Signal Transduction / Q000235:genetics; D014178:Translocation, Genetic; D018631:ras Proteins / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D018631:ras Proteins