Oligomannan synthesis using ionic liquid supported glycosylation.
The synthesis of complex oligosaccharides has been a challenge for researchers. Herein, we describe a strategy for the synthesis of an activated oligomannan 1 that employs ionic liquid (IL) support glycosylation methodology on an IL-tagged mannosyl fluoride donor. This method is capable of rapidly producing linear alpha(1-->6) oligomannan thioglycosides in a convenient and cost-effective manner without the need of column purification after each glycosylation step.
Pathak
Ashish K
AK
Department of Chemistry, Western Illinois University, Macomb, Illinois 61455, USA. ak-pathak@wiu.edu
Yerneni
Charu K
CK
Young
Zac
Z
Pathak
Vibha
V
D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry; D006031:Glycosylation; D008351:Mannans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D006027:Glycosides; D008351:Mannans