Innate immunity as a driving force in renal disease.
Mrug et al. propose that innate immunity is a hallmark of progressive polycystic kidney disease (PKD). We propose that innate immunity is a driving force in the progression of many renal diseases. Renal epithelial cells are capable of expressing a large variety of proinflammatory genes resulting in the production of cytokines, chemokines, cell-adhesion molecules, and complement components. We suggest that future therapeutic interventions should be directed toward control of innate immunity in renal disease.
de Heer
E
E
Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. e.de_heer@lumc.nl
Peters
D J M
DJ
D015815:Cell Adhesion Molecules / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D007674:Kidney Diseases / Q000276:immunology*
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D003165:Complement System Proteins