The impact of a false-positive MRI on the choice for mastectomy in BRCA mutation carriers is limited.
OBJECTIVE
To assess the false-positive rate of breast cancer surveillance by magnetic resonance imaging (MRI) in BRCA mutation carriers and the impact of an abnormal mammography or breast MRI on the patients' decision for prophylactic mastectomy.


METHODS
A total of 196 BRCA mutation carriers were included with a median follow-up of 2 years (range 1-9) with annual mammography and MRI. Preference for prophylactic mastectomy was registered at first surveillance after the mutation carriership was revealed.


RESULTS
In all, 41% (81 of 196) of the women had at least one positive MRI or mammography. Malignancy was detected in 17 women: 11 at surveillance, 4 at an intended prophylactic mastectomy and 2 had an interval cancer. Imaging by mammography and MRI had a sensitivity of 71% and a specificity of 90%. The probability that a positive MRI result is false positive was 83%. In the group with a prior preference for mastectomy with and without a false-positive imaging, prophylactic mastectomy was carried out in 89% and 66%, respectively (P = 0.06), in the group with prior preference for surveillance these percentages were 15% and 11%, respectively (P = 0.47).


CONCLUSIONS
Although the rate of false-positive MRI results is high, the impact on the choice for prophylactic mastectomy is limited and is determined by the woman's preference before the establishment of a BRCA mutation.
Hoogerbrugge
N
N
Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. n.hoogerbrugge@antrg.umcn.nl
Kamm
Y J L
YJ
Bult
P
P
Landsbergen
K M
KM
Bongers
E M H F
EM
Brunner
H G
HG
Bonenkamp
H J
HJ
de Hullu
J A
JA
Ligtenberg
M J L
MJ
Boetes
C
C
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000517:prevention & control; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000517:prevention & control; D002755:Choice Behavior; D005189:False Positive Reactions; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008875:Middle Aged; D009154:Mutation; D010052:Ovariectomy; D011159:Population Surveillance / Q000379:methods; D011322:Primary Prevention / Q000379:methods*