Additive immunosuppressive effect of hydroxycamptothecin and cyclosporine on rejection of heart transplantation in rats.
OBJECTIVE
The objective of this study was to study the inhibitory effects of hydroxycamptothecin (HCPT) and cyclosporine (CsA) on heart transplantation rejection in rats.


METHODS
Inbred SD rats were used as donors and inbred Wistar rats as recipients. Cervical heterotopic heart transplantation was performed in 40 rats: group A received placebo; group B, HCPT; group C, CsA; group D, HCPT+CsA.


RESULTS
The mean survival time was prolonged in group D with 5 grafts beating at more than 730 days.


CONCLUSIONS
HCPT combined with CsA prevented acute rejection of allogeneic heart transplantations in rats, significantly prolonging graft mean survival time.
Shi
B
B
Transplantation Center, Second Affiliated Hospital, General Hospital of PLA, Beijing, People's Republic of China.
Cai
M
M
Qian
Y
Y
Zhou
W
W
Mo
C
C
Wang
Y
Y
D000818:Animals; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D002166:Camptothecin