Neurobiological substrates of electroconvulsive therapy for Tourette syndrome: a Serial SISCOM study.
We report the case of an adult male patient with Tourette syndrome, self-injurious behavior and depression, refractory to conventional treatment, and whose symptoms remitted after electroconvulsive therapy. Serial Technetium 99m-Ethyl-Cysteinate-Dimer single photon emission tomographies were applied, before, during, and after electroconvulsive therapy. The neural substrates of this treatment process were further analyzed by woxel-wise subtracted single photon emission tomography images.
Morais
Silvio Luiz
SL
Department of Neurology, Psychiatry, and Clinical Psychology, São Paulo, Brazil.
Derenusson
Guilherme Nogueira
GN
Pinto
Joel Porfirio
JP
Hounie
Ana Gabriela
AG
Dursun
Serdar Murat
SM
Wichert-Ana
Lauro
L
Kato
Mery
M
de Oliveira
Lucas Ferrari
LF
de Azevedo-Marques
Paulo Mazzoncini
PM
Sakamoto
Américo Ceiki
AC
Hallak
Jaime Eduardo Cecílio
JE
D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D010054:Brief Psychiatric Rating Scale; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D003131:Combined Modality Therapy; D003545:Cysteine / Q000031:analogs & derivatives; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D015609:Organotechnetium Compounds; D011619:Psychotropic Drugs / Q000008:administration & dosage; D012039:Regional Blood Flow / Q000502:physiology; D016728:Self-Injurious Behavior / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon; D005879:Tourette Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*
D015609:Organotechnetium Compounds; D011619:Psychotropic Drugs; C059659:technetium Tc 99m bicisate; D003545:Cysteine