title: Fabrication of fast responsive, thermosensitive poly(N-isopropylacrylamide) hydrogels by using diethyl ether as precipitation agent.
abstract: An effective strategy was developed and demonstrated to improve the properties of thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) hydrogel by using diethyl ether as a precipitation agent during the polymerization/crosslinking. Results reveal that the modified PNIPAAm hydrogels have the heterogeneous network structures and decreased LCSTs in a comparison with the normal PNIPAAm hydrogel. The modified PNIPAAm hydrogels also exhibit significantly improved sensitive properties, including fast response and stable, rapid, large magnitude oscillatory shrinking-swelling upon temperature cycles around lower critical solution temperature. In addition, fish DNA, used as a model drug, is loaded into the modified PNIPAAm hydrogels, the controlled release behaviors of the drug loaded hydrogels at different temperatures (22 and 37 degrees C) are further examined.
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
authors: Xiao-Ding
authors: XD
authors: Xu
authors: Bo
authors: B
authors: Wang
authors: Zong-Chun
authors: ZC
authors: Wang
authors: Si-Xue
authors: SX
authors: Cheng
authors: Xian-Zheng
authors: XZ
authors: Zhang
authors: Ren-Xi
authors: RX
authors: Zhuo
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry; D000180:Acrylic Resins; D002152:Calorimetry, Differential Scanning; D011232:Chemical Precipitation; D004247:DNA / Q000494:pharmacology; D016503:Drug Delivery Systems; D004986:Ether / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D013499:Surface Properties / Q000187:drug effects; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D020100:Hydrogels; D011108:Polymers; D012996:Solutions; D004986:Ether; C052970:poly-N-isopropylacrylamide; D004247:DNA