Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
Jaeger
Emma
E
Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK.
Webb
Emily
E
Howarth
Kimberley
K
Carvajal-Carmona
Luis
L
Rowan
Andrew
A
Broderick
Peter
P
Walther
Axel
A
Spain
Sarah
S
Pittman
Alan
A
Kemp
Zoe
Z
Sullivan
Kate
K
Heinimann
Karl
K
Lubbe
Steven
S
Domingo
Enric
E
Barclay
Ella
E
Martin
Lynn
L
Gorman
Maggie
M
Chandler
Ian
I
Vijayakrishnan
Jayaram
J
Wood
Wendy
W
Papaemmanuil
Elli
E
Penegar
Steven
S
Qureshi
Mobshra
M
Farrington
Susan
S
Tenesa
Albert
A
Cazier
Jean-Baptiste
JB
Kerr
David
D
Gray
Richard
R
Peto
Julian
J
Dunlop
Malcolm
M
Campbell
Harry
H
Thomas
Huw
H
Houlston
Richard
R
Tomlinson
Ian
I
D000236:Adenoma / Q000235:genetics; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002884:Chromosomes, Human, Pair 15; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007585:Jews / Q000235:genetics; D020641:Polymorphism, Single Nucleotide