title: Correlations between alder specific IgE and alder-related tree pollen specific IgE by RAST method.
abstract: BACKGROUND
  Wild birch trees grow in limited areas in Japan and are not a common aero-allergen. However, many patients who do not live in the area show positive birch pollen Radioallergosorbent Test (RAST). Therefore, being sensitized by another tree pollen which is closely related to birch may result in showing a specific IgE antibody to birch. Alder is a one of these trees and in the past it grew widely in Japan. However, there is no available RAST data as to the correlations between alder and alder-related trees.
  
  
  METHODS
  We measured the alder specific IgE (CAP-RAST, Phadea) in stored sera which was positive in birch RAST (228 samples), beech RAST (36 samples), oak RAST (152 samples) and cedar RAST (411 samples) and examined correlations between the RAST of alder and other trees.
  
  
  RESULTS
  The correlation coefficient value of birch was very high (0.971). The other coefficient values of beech and oak were high (0.884 in beech and 0.895 in oak) but were slightly lower than that of the birch. This means that in terms of allergenicities, birch pollen is almost the same as alder and beech and oak are partly different from the alder.
  
  
  CONCLUSIONS
  The Japanese respond to alder pollen just same as they do to birch pollen in forming specific IgE antibody. In clinical practice, positive alder RAST has the same meaning as positive birch RAST.
authors: Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan. y-maeda@sagamihara-hospital.gr.jp
authors: Yuji
authors: Y
authors: Maeda
authors: Emiko
authors: E
authors: Ono
authors: Yuma
authors: Y
authors: Fukutomi
authors: Masami
authors: M
authors: Taniguchi
authors: Kazuo
authors: K
authors: Akiyama
mesh_terms: D000485:Allergens; D029661:Alnus; D052179:Antigens, Plant / Q000276:immunology; D029662:Betula; D000939:Epitopes; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007564:Japan; D018716:Molecular Mimicry / Q000276:immunology; D011058:Pollen; D011852:Radioallergosorbent Test / Q000379:methods; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D000939:Epitopes; D007073:Immunoglobulin E