title: Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse.
abstract: The present study examined the influence of pharmacological modulations of the locus coeruleus noradrenergic system on odor recognition in the mouse. Mice exposed to a nonrewarded olfactory stimulation (training) were able to memorize this odor and to discriminate it from a new odor in a recall test performed 15 min later. At longer delays (30 or 60 min), the familiar odor was no longer retained, and both stimuli were perceived as new ones. Following a post-training injection of the alpha(2)-adrenoceptor antagonist dexefaroxan, the familiar odor was still remembered 30 min after training. In contrast, both the alpha(2)-adrenoceptor agonist UK 14304 and the noradrenergic neurotoxin DSP-4 prevented the recognition of the familiar odor 15 min after the first exposure. Noradrenaline release in the olfactory bulb, assessed by measurement of the extracellular noradrenaline metabolite normetanephrine, was increased by 62% following dexefaroxan injection, and was decreased by 38%-44% after treatment with UK 14304 and DSP-4. Performance of mice in the recall test was reduced by a post-training injection of the beta-adrenoceptor antagonist propranolol or the alpha(1)-antagonist prazosin, thus implicating a role for beta- and alpha(1)-adrenoceptors in the facilitating effects of noradrenaline on short-term olfactory recognition in this model.
authors: Neurosciences Sensorielles, Comportement, Cognition, CNRS-UMR 5020, Université de Lyon, Université Claude Bernard-Lyon 1, 69366 Lyon, France.
authors: Alexandra
authors: A
authors: Veyrac
authors: Véronique
authors: V
authors: Nguyen
authors: Marc
authors: M
authors: Marien
authors: Anne
authors: A
authors: Didier
authors: François
authors: F
authors: Jourdan
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001578:Benzopyrans / Q000494:pharmacology; D001596:Benzylamines / Q000494:pharmacology; D000068438:Brimonidine Tartrate; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000502:physiology*; D009812:Odorants; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D012903:Smell / Q000187:drug effects / Q000502:physiology*
chemical_list: D018663:Adrenergic Agents; D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D001596:Benzylamines; D007093:Imidazoles; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D011433:Propranolol; C451723:dexefaroxan; C012102:DSP 4; D009638:Norepinephrine; D011224:Prazosin