[PRP(CJD) reproduction in the cerebral vascular plexus epitheliocytes in a new type of Creutzfeldt-Jakob disease].
The study of brain histological specimens from patients with Creutzfeldt-Jakob disease (CJD) revealed the active reproduction and accumulation of pathological prions in the epitheliocytes of cerebral vascular brain plexuses in a new variant of CJD. There was PrPCD accumulation on the cerebral ventricular ependymal cells and in the subpial superficial cortex parts of the cerebellum and brain to give rise to diffuse clusters, immature and kuru-plaques. Morphological changes in the blood-cerebrospinal fluid and cerebrospinal fluid-brain barriers are described and the possible pathways of intracerebral distribution of prions with cerebrospinal fluid considered.
Karmysheva
V Ia
VIa
Pogodina
V V
VV
D002525:Cerebellar Cortex / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology*; D004805:Ependyma / Q000378:metabolism / Q000473:pathology; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D018620:PrPSc Proteins / Q000378:metabolism*
D018620:PrPSc Proteins