title: Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase.
abstract: A new approach was developed for the synthesis of 4'-modified neplanocin A analogues, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinylstannane 13, a key intermediate in the present approach, was prepared by radical-mediated sulfur-extrusive stannylation.
authors: School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. kumamoto@pharm.showa-u.ac.jp
authors: Hiroki
authors: H
authors: Kumamoto
authors: Kazuki
authors: K
authors: Deguchi
authors: Nonoko
authors: N
authors: Takahashi
authors: Hiromichi
authors: H
authors: Tanaka
authors: Yukio
authors: Y
authors: Kitade
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013455:Sulfur / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D013455:Sulfur; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine