title: Ventilatory control during intermittent high-intensity exercise in humans.
abstract: Intermittent supra-maximal cycling of varying work: recovery durations was used to explore the kinetics of respiratory compensation for the metabolic acidosis of high-intensity exercise (> lactate threshold, thetaL). For a 10:20s duty-cycle, blood [lactate] ([L-]) was not increased, and there was no evidence of respiratory compensation (RC); i.e, no increase in the ventilation (VE)-CO2 output (Vco2) slope, nor fall in end-tidal PCO2 (PETCO2). For longer duty-cycles, [L-] was elevated, stabilizing (30s:60 s exercise) or rising progressively (60s:120s, 90s: 180s exercise). In addition, Vco2 and VE now oscillated with WR, with evidence of delayed RC (progressive increase in VE - VCO2 slope; decrease in PETCO2) being more marked with longer duty-cycles. These results, which extend earlier findings with supra- thetaL step and ramp exercise, are not consistent with an appreciable contribution to RC from zero-order central command or peripheral neurogenesis. The reasons for the slow RC kinetics are unclear, but may reflect in part the H(+)-signal transduction properties of carotid chemoreceptors.
authors: University of Glasgow, Institute of Biomedical & Life Sciences. A.Cathcart@bio.gla.ac.uk
authors: Andrew J
authors: AJ
authors: Cathcart
authors: Anthony P
authors: AP
authors: Turner
authors: Christopher
authors: C
authors: Butterworth
authors: Matthew
authors: M
authors: Parker
authors: John
authors: J
authors: Wilson
authors: Susan A
authors: SA
authors: Ward
mesh_terms: D000204:Activity Cycles; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006706:Homeostasis; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D012143:Respiratory Physiological Phenomena; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen