title: The retrotrapezoid nucleus and central chemoreception.
abstract: Central respiratory chemoreception (CRC) is the mechanism by which brain pCO2 regulates breathing. The molecular and cellular basis of CRC is still poorly understood. In this review, we describe the properties of a cluster of pH-responsive neurons located in the retrotrapezoid region of the medulla oblongata and analyze whether these cells qualify as central respiratory chemoreceptors.
authors: University of Virginia, Department of Pharmacology, USA. pgg@virginia.edu
authors: Patrice G
authors: PG
authors: Guyenet
authors: Douglas A
authors: DA
authors: Bayliss
authors: Daniel K
authors: DK
authors: Mulkey
authors: Ruth L
authors: RL
authors: Stornetta
authors: Thiago S
authors: TS
authors: Moreira
authors: Ana T
authors: AT
authors: Takakura
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology; D002628:Chemoreceptor Cells / Q000502:physiology*; D045853:Exhalation / Q000502:physiology; D008526:Medulla Oblongata / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D012143:Respiratory Physiological Phenomena; D014628:Vagotomy
chemical_list: D002245:Carbon Dioxide