title: "JIP"ing along the axon: the complex roles of JIPs in axonal transport.
abstract: JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to Kinesin-I, a major molecular motor for axonal transport. Recent research sheds further light on JIPs' complex roles in axonal transport, namely in activation of Kinesin-I and in cargo release. In Drosophila, APLIP1/JIP1 allows the Kinesin-I complex to enable cargo release through activation of JNK signaling.1 In mammalian cell culture, JIP1 is necessary and, together with UNC-76/FEZ1, sufficient for activating Kinesin-I.2 I discuss and compare the many roles played by JIP1 and JIP3 through interactions with several distinct players, in retrograde as well as anterograde transport.
authors: NCBS-TIFR, Bellary Road, Bangalore-560065, India. koushika@ncbs.res.in
authors: Sandhya P
authors: SP
authors: Koushika
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D008954:Models, Biological; D005810:Multigene Family / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: C524132:APP-like protein interacting protein 1, Drosophila; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; C490666:MAPK8IP1 protein, human; C485750:MAPK8IP3 protein, human; D009419:Nerve Tissue Proteins; C515209:Khc protein, Drosophila; D016547:Kinesins