title: Lack of association between the MEF2A gene and myocardial infarction.
abstract: BACKGROUND
  Coronary artery disease (CAD) and myocardial infarction (MI) are caused in part by genetic factors. Recently, the MEF2A gene was linked to MI/CAD in a single pedigree with autosomal-dominant pattern of inheritance. In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results.
  
  
  RESULTS
  The MEF2A gene was sequenced in MI patients from 23 MI families (> or =5 affected members per family), but no mutation was identified in any of these extended families. Moreover, the Pro279Leu variant in exon 7 was analyzed in 1181 unrelated MI patients with a positive family history for MI/CAD, in 533 patients with sporadic MI, and in 2 control populations (n=1021 and n=1055), showing no evidence for association with MI/CAD. In addition, a (CAG)n repeat in exon 11 was genotyped in 543 sporadic MI patients and in 1190 controls without evidence for association with MI. Finally, analyzing 11 single-nucleotide polymorphisms from the GeneChip Mapping 500K Array, genotyped in 1644 controls and 753 cases, failed to provide evidence for association (region-wide P=0.23).
  
  
  CONCLUSIONS
  Studying independent samples of >1700 MI patients, 2 large control populations, and multiple families with apparently mendelian inheritance of the disease, we found no evidence for any linkage or association signal in the MEF2A gene.
authors: Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany.
authors: Wolfgang
authors: W
authors: Lieb
authors: Björn
authors: B
authors: Mayer
authors: Inke R
authors: IR
authors: König
authors: Iris
authors: I
authors: Borwitzky
authors: Anika
authors: A
authors: Götz
authors: Silke
authors: S
authors: Kain
authors: Christian
authors: C
authors: Hengstenberg
authors: Patrick
authors: P
authors: Linsel-Nitschke
authors: Marcus
authors: M
authors: Fischer
authors: Angela
authors: A
authors: Döring
authors: H-Erich
authors: HE
authors: Wichmann
authors: Thomas
authors: T
authors: Meitinger
authors: Reinhold
authors: R
authors: Kreutz
authors: Andreas
authors: A
authors: Ziegler
authors: Heribert
authors: H
authors: Schunkert
authors: Jeanette
authors: J
authors: Erdmann
mesh_terms: D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005192:Family Health; D006801:Humans; D040582:Inheritance Patterns; D026161:MADS Domain Proteins / Q000235:genetics*; D064326:MEF2 Transcription Factors; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D018006:Myogenic Regulatory Factors / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578035:MEF2A protein, human; D018006:Myogenic Regulatory Factors