A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.
This retrospective cohort study conducted at the Durham Veterans Affairs Medical Center evaluated the effectiveness and safety of lipid-lowering therapy (LLT) in a HIV-infected population as compared with a general population with hyperlipidaemia. Fifty-three HIV-infected subjects who developed dyslipidaemia and 53 age-matched non-HIV-infected subjects receiving LLT were selected. Efficacy of LLT was assessed after three and six months. Non-HIV-infected subjects were more likely to achieve total cholesterol (TC) goals at three and six months (P = 0.045, P = 0.005) and triglyceride (TG) goals at six months (P = 0.017). Less than 45% of HIV-infected subjects met National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) goals at three or six months. While non-HIV-infected subjects were more likely to achieve TC and TG goals than HIV-infected subjects, overall achievement of NCEP III goals was poor. This result was likely due to treatment with inappropriately low doses of statins.
Townsend
Mary L
ML
Department of Pharmacy Practice, Campbell University School of Pharmacy, Buies Creek, NC, USA. townsend@mailcenter.campbell.edu
Hollowell
Stephanie B
SB
Bhalodia
Jasmin
J
Wilson
Kenneth H
KH
Kaye
Keith S
KS
Johnson
Melissa D
MD
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D002995:Clofibric Acid / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000627:therapeutic use; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D005395:Fish Oils; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002995:Clofibric Acid; D002784:Cholesterol; D017035:Pravastatin