title: [Tuberculosis and HIV infection--main diagnostic and therapeutic problems].
abstract: Tuberculosis pertains to every third HIV-positive person in a world. Therefore HIV infection is considered the most evident risk factor for the primary tuberculosis or relapse of latent tubercular infection. Pulmonary tuberculosis is the most frequent clinical presentation in HIV-positive individuals, although the frequency of extrapulmonary tuberculosis is increasing with the CD4+ count reduction. Tuberculin skin testing and bacteriological tests are regarded as a "gold standard" of diagnosis. Molecular diagnostics and evaluation of a whole-blood interferon-gamma release assay for the detection of Mycobacterium tuberculosis are not cost-effective therefore their application is limited. DOTS programs are recommended for the antimycobacterial treatment in HIV-infected patients. The increasing drug resistance of Mycobacterium tuberculosis (multi-drug resistant tuberculosis--MDRTB) is emerging problem in the field of tuberculosis management.
authors: Akademia Medyczna w Białymstoku, Klinika Obserwacyjno-Zakaźna.
authors: Magdalena M
authors: MM
authors: Dabrowska
authors: Joanna
authors: J
authors: Pogorzelska
authors: Anna
authors: A
authors: Parfieniuk
authors: Ewa
authors: E
authors: Siwak
authors: Alicja
authors: A
authors: Wiercińska-Drapało
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D024901:Drug Resistance, Multiple, Bacterial; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents