title: Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection.
abstract: Thai patients enrolled in STACCATO with HIV/hepatitis B virus (HBV) co-infection and tenofovir/emtricitabine-based antiretroviral therapy (ART) were randomly assigned to continuous treatment or CD4 cell count-guided interruptions. HBV replication was suppressed below detection in 15/16 patients. Structured treatment interruption increased transaminases and HBV viraemia in five of six patients; one flare was severe. Conversion to anti-hepatitis Be occurred with continuous treatment only. Tenofovir/emtricitabine-containing ART is highly effective in controlling chronic HIV/HBV co-infection but treatment should not be interrupted.
authors: HIV-NAT, The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
authors: Reto
authors: R
authors: Nüesch
authors: Jintanat
authors: J
authors: Ananworanich
authors: Preeyaporn
authors: P
authors: Srasuebkul
authors: Ploenchan
authors: P
authors: Chetchotisakd
authors: Wisit
authors: W
authors: Prasithsirikul
authors: Wirat
authors: W
authors: Klinbuayam
authors: Apicha
authors: A
authors: Mahanontharit
authors: Thidarat
authors: T
authors: Jupimai
authors: Kiat
authors: K
authors: Ruxrungtham
authors: Bernard
authors: B
authors: Hirschel
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000008:administration & dosage*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D000068679:Emtricitabine; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage*; D000068698:Tenofovir; D013785:Thailand; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D000998:Antiviral Agents; D006513:Hepatitis B e Antigens; D063065:Organophosphonates; D003841:Deoxycytidine; D000068698:Tenofovir; D000637:Transaminases; D000068679:Emtricitabine; D000225:Adenine