title: Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
abstract: We have examined our ionizing radiation survival data for 33 xeroderma pigmentosum (XP) primary fibroblast lines and compared the data to that of 53 normal fibroblast lines, 7 Cockayne syndrome (CS) lines, 4 combined XP/CS lines and 8 ataxia-telangiectasia fibroblast lines. Although there are differences in radiosensitivity between cell lines within each class, we have no convincing evidence that XP lines as a group are more sensitive to ionizing radiation than the general population. However, because the XP phenotype may lead to premature ageing, especially of sun-exposed tissues, we would still advocate caution when XP patients come to radiotherapy. Our results confirm the extreme ionizing radiation hypersensitivity of ataxia-telangiectasia; they are also consistent with a tendency for slight hypersensitivity in CS, but not (necessarily) in combined XP/CS.
authors: Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ. colin-a@solutions-inc.co.uk
authors: C F
authors: CF
authors: Arlett
authors: M H L
authors: MH
authors: Green
authors: P B
authors: PB
authors: Rogers
authors: A R
authors: AR
authors: Lehmann
authors: P N
authors: PN
authors: Plowman
mesh_terms: D001260:Ataxia Telangiectasia / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003057:Cockayne Syndrome / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D011836:Radiation Tolerance; D014983:Xeroderma Pigmentosum / Q000473:pathology*