[Suppression of immune response associated with functions of B-cells, Th1- and Th2-lymphocytes and interleukins produced by these cells, and pharmacological correction of these disturbances upon acute intoxication with methanol].
Experiments on Wistar rats showed that acute poisoning with methanol (0.75 LD50) leads to the suppression of cellular and humoral immune responses and decreases the blood concentration of interleukins (IL-2, IL-4) with an increase in the IL-2/IL-4 ratio. These facts indicate that a decrease in Th2 lymphocyte activity is more pronounced in comparison to that of Th1 cells. The immunomodulators mielopide and polyoxidon administered in a daily dose of 10 mg/kg for 4 days upon acute poisoning with methanol virtually completely restore the cellular and humoral immune responses, the activity of natural killers, and the synthesis of interleukins.
Zabrodskiĭ
P F
PF
Mandych
V G
VG
Kirichuk
V F
VF
Serov
V V
VV
Plakhuta
I A
IA
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D007378:Interleukins / Q000096:biosynthesis / Q000276:immunology*; D008297:Male; D000432:Methanol / Q000506:poisoning*; D009842:Oligopeptides / Q000494:pharmacology; D009930:Organic Chemicals / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D007155:Immunologic Factors; D007376:Interleukin-2; D007378:Interleukins; D009842:Oligopeptides; D009930:Organic Chemicals; C089921:polyoxydonium; C048617:myelopeptides; D015847:Interleukin-4; D000432:Methanol