title: TNF and sTNFR1/2 plasma levels in ALS patients.
abstract: The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.
authors: Neurological Institute IRCCS "C. Mondino", Pavia, Italy. cristina.cereda@mondino.it
authors: Cristina
authors: C
authors: Cereda
authors: Chiara
authors: C
authors: Baiocchi
authors: Paolo
authors: P
authors: Bongioanni
authors: Emanuela
authors: E
authors: Cova
authors: Stefania
authors: S
authors: Guareschi
authors: Maria Rita
authors: MR
authors: Metelli
authors: Bruno
authors: B
authors: Rossi
authors: Ilaria
authors: I
authors: Sbalsi
authors: Maria Clara
authors: MC
authors: Cuccia
authors: Mauro
authors: M
authors: Ceroni
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000235:genetics / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012150:Polymorphism, Restriction Fragment Length; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood* / Q000235:genetics / Q000502:physiology; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood* / Q000235:genetics / Q000502:physiology; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000235:genetics / Q000502:physiology
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha