Expression of Co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis.
Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.
Fesenkova
Valentyna I
VI
The Bogomolets National Medical University, The Immunological Laboratory of the Institute of Urology, AMS of Ukraine.
Kurchenko
Anita I
AI
Castellani
Maria Luisa
ML
Conti
Pio
P
Anogeianaki
Antonia
A
Caraffa
Auro
A
Kalogeromitros
Dimitris
D
D000818:Animals; D018949:Antigens, CD1 / Q000378:metabolism; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen / Q000378:metabolism; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000473:pathology; D004485:Eczema / Q000378:metabolism / Q000473:pathology; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000378:metabolism*; D051379:Mice
D018949:Antigens, CD1; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C419393:CD1a antigen; D007136:Immunoglobulins