Regulation of heterotrimeric G protein signaling in airway smooth muscle.
Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.
Penn
Raymond B
RB
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. rpenn@wfubmc.edu
Benovic
Jeffrey L
JL
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D009130:Muscle, Smooth / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism*; D015398:Signal Transduction
D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D043562:Receptors, G-Protein-Coupled