title: Treatment with tigecycline of recurrent urosepsis caused by extended-spectrum-beta-lactamase-producing Escherichia coli.
abstract: A 25-year-old female was admitted to our intensive care unit with septic shock and multiorgan failure caused by extended-spectrum beta-lactamase-producing Escherichia coli originating from the right renal pelvis. A 16-day course of treatment with meropenem reversed the septic condition, but the infection recurred thereafter. The patient recovered fully after therapy was changed to tigecycline.
authors: Tübingen University Hospital, Department of Anesthesiology and Intensive Care Medicine, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. wolfgang.krueger@uni-tuebingen.de
authors: Wolfgang A
authors: WA
authors: Krueger
authors: Volkhard A J
authors: VA
authors: Kempf
authors: Manou
authors: M
authors: Peiffer
authors: Udo
authors: U
authors: Nagele
authors: Klaus E
authors: KE
authors: Unertl
authors: Torsten H
authors: TH
authors: Schroeder
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D000077731:Meropenem; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012008:Recurrence; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology; D013845:Thienamycins / Q000627:therapeutic use; D000078304:Tigecycline; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000078304:Tigecycline; D001618:beta-Lactamases; D000077731:Meropenem; D008911:Minocycline