title: Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin.
abstract: Thiazolidinediones are ligands of PPAR-gamma, a member of the nuclear receptor family. These drugs have shown promising pre-clinical activity in tumor models but clinical studies failed to confirm their beneficial effect. We have studied the in vitro antitumor effects of a combination of ciglitazone, a thiazolidinedione drug, and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. We observed a marked synergism in several different tumor cell lines resulting from both inhibition of cell proliferation and induction of apoptosis. These results strongly suggest that combining PPAR-gamma agonists with statins can produce significant antitumor effects.
authors: Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, 02-097 Warsaw, Poland.
authors: Piotr
authors: P
authors: Mrówka
authors: Eliza
authors: E
authors: Glodkowska
authors: Dominika
authors: D
authors: Nowis
authors: Magdalena
authors: M
authors: Legat
authors: Tadeusz
authors: T
authors: Issat
authors: Marcin
authors: M
authors: Makowski
authors: Angelika
authors: A
authors: Szokalska
authors: Sylwia
authors: S
authors: Janowska
authors: Tomasz
authors: T
authors: Stoklosa
authors: Marek
authors: M
authors: Jakóbisiak
authors: Jakub
authors: J
authors: Golab
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000032:analysis; D004357:Drug Synergism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis; D008148:Lovastatin / Q000494:pharmacology*; D051379:Mice; D047495:PPAR gamma / Q000819:agonists*; D045162:Thiazolidinediones / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; C436291:CDKN1B protein, human; C493961:Cdkn1b protein, mouse; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D047495:PPAR gamma; D045162:Thiazolidinediones; D050760:Cyclin-Dependent Kinase Inhibitor p27; D008148:Lovastatin; C039671:ciglitazone