Molecular imaging of reporter gene expression in prostate cancer: an overview.
Prostate cancer remains an important and growing health problem. Advances in imaging of prostate cancer may help to achieve earlier and more accurate diagnosis and treatment. We review the various strategies using reporter genes for molecular imaging of prostate cancer. These approaches are emerging as valuable tools for monitoring gene expression in laboratory animals and humans. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of reporter gene imaging as a versatile method for understanding of intracellular biological processes and the underlying molecular basis of prostate cancer, as well as potentially establishing a future role in the clinical management of patients afflicted with this disease.
Singh
Abhinav
A
Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Massoud
Tarik F
TF
Deroose
Christophe
C
Gambhir
Sanjiv S
SS
D014408:Biomarkers, Tumor / Q000378:metabolism*; D003952:Diagnostic Imaging / Q000379:methods*; D017930:Genes, Reporter; D006801:Humans; D008297:Male; D015336:Molecular Probe Techniques; D009363:Neoplasm Proteins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins