title: Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice.
abstract: Administration of the PPARgamma agonist GW1929 (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia. The effect of the agonist, which seems to be specific for white muscle extensor digitorum longus (EDL), is accompanied by an increase in the levels of the transcription factor MyoD and also the GLUT-4 glucose transporter. In addition, the effects of GW1929 on skeletal muscle are direct since incubation of isolated rat skeletal muscles in its presence results in a decreased rate of protein degradation. Collectively, the results presented suggest a potential clinical application - possibly in combination with other anabolic strategies - of GW1929 in restoring muscle waste during cancer cachexia.
authors: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain.
authors: Rodrigo
authors: R
authors: Moore-Carrasco
authors: Maite
authors: M
authors: Figueras
authors: Elisabet
authors: E
authors: Ametller
authors: Francisco J
authors: FJ
authors: López-Soriano
authors: Josep M
authors: JM
authors: Argilés
authors: Sílvia
authors: S
authors: Busquets
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D015153:Blotting, Western; D002100:Cachexia / Q000209:etiology* / Q000503:physiopathology*; D018827:Carcinoma, Lewis Lung / Q000150:complications*; D051275:Glucose Transporter Type 4 / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D047495:PPAR gamma / Q000037:antagonists & inhibitors*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D001577:Benzophenones; D051275:Glucose Transporter Type 4; D047495:PPAR gamma; D014443:Tyrosine; C120099:GW 1929