Breast cancer in intraductal carcinogen-treated non-human primates.
Eight female Macaca arctoides monkeys were given dimethylbenzanthracene (DMBA) directly into the milk ducts. During a 4-year observation period, ending with euthanasia and autopsy, no mammary cancers were noticed. However, one animal developed a superficial localized squamous cell carcinoma. DMBA is highly carcinogenic in rodents, e.g. producing a high incidence of breast cancer in C3H mice. It was concluded that carcinogenicity testing should be extended beyond testing in rodents to non-human primates in order to distinguish "primary rodent carcinogens" from those highly active in primates as well. Studies are in progress to study carcinogens in human cell lines transplanted into nu/nu mice.
Lillie
Madeline A
MA
Department of Pediatrics, State University of NY at Buffalo School of Medicine and Biomedical Sciences and the Graduate School, Buffalo General Hospital Kaleida Health System, Buffalo, NY 14203, USA.
Ambrus
Clara M
CM
Pickren
John W
JW
Akhter
Selina
S
Islam
Abul
A
Ambrus
Julian L
JL
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D004333:Drug Administration Routes; D005260:Female; D008251:Macaca; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced*
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene