[Update of the researches on the niche for spermatogonial stem cells].
Spermatogonial stem cells are a population of immortal cells, capable of self-renewal and multi-directional differentiation. The theory of the "stem cell niche" was originally proposed for the hematopoietic system, and niches also exist in testicular tissues. The niche for spermatogonial stem cells is a semi-isolation system, characteristic of specific number regulation and changing with the age. The self-renewal of spermatogonial stem cells is regulated by two endogenous factors, nanos2 and Plzf, as well as by the niche cell-excreted factor, glial-derived neurotrophic factor (GDNF).
Hou
Lin
L
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Yao
Bing
B
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism; D008297:Male; D051379:Mice; D016601:RNA-Binding Proteins; D013093:Spermatogonia / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D013737:Testis / Q000166:cytology* / Q000378:metabolism
D002352:Carrier Proteins; D051100:Glial Cell Line-Derived Neurotrophic Factor; C477341:Nanos2 protein, mouse; D016601:RNA-Binding Proteins