Exposure to T-cycles of 22 and 23 h during lactation modifies the later dissociation of motor activity and temperature circadian rhythms in rats.
Early environmental conditions may affect the development and manifestation of circadian rhythms. This study sought to determine whether the maintenance of rats under different T-cycles during lactation influences the subsequent degree of dissociation of the circadian rhythms of motor activity and core body temperature. Two groups of 22 day-old Wistar rats were kept after weaning under T-cycles of 22 h (T22) or 23 h (T23) for 70 days. Subsequently, they were kept in constant darkness (DD). Half of the animals in each group were born and reared under these experimental conditions, while the other half were reared until weaning under 24 h LD cycles (T24). Rats transferred from T24 to T22 or T23 showed two circadian components in motor activity and temperature, one entrained by light and the other free-running. In T22, there was also desynchronization between temperature and motor activity. Rats submitted to T23 from birth showed higher stability of the 23 h component than rats transferred from T24 to T23 after weaning. However, in comparison to rats born under T24 and subsequently changed to T22, animals submitted to T22 from birth showed shorter values of the period of the non-light-dependent component during T22, more aftereffects when transferred to DD, and a lack of desynchronization between motor activity and temperature. The results suggest that T-cycles in the early environment may modify overt rhythms by altering the internal coupling of the circadian pacemaker.
Anglès-Pujolràs
Montserrat
M
Facultat de Farmàcia, Departament de Fisiologia, Universitat de Barcelona, Barcelona, Spain.
Díez-Noguera
Antoni
A
Cambras
Trinitat
T
D000204:Activity Cycles / Q000502:physiology*; D000375:Aging / Q000502:physiology; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006321:Heart / Q000502:physiology*; D007774:Lactation / Q000502:physiology*; D008297:Male; D009043:Motor Activity; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000502:physiology; D013696:Temperature