Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways.
The present article will describe the potential role of airway smooth muscle (ASM) in mediating both deleterious/beneficial effects of interferons (IFNs) in asthma. First described as beneficial in treating the main features of asthma, the interplay between IFNs and ASM could explain their deleterious actions recently described in a number of different studies. Through multiple mechanisms, including the suppression of steroid action, the synergistic pro-inflammatory actions when combined with other cytokines, and the modulation of calcium metabolism, IFNs are now seen as critical mediators in the pathogenesis of asthma.
Tliba
Omar
O
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Amrani
Yassine
Y
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007372:Interferons / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000276:immunology*; D020545:Respiratory Mucosa / Q000276:immunology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons