Clomiphene citrate for treatment refractory chronic cluster headache.
A treatment refractory chronic cluster headache patient is presented who became cluster-free on clomiphene citrate. The author has previously reported a SUNCT patient responding to clomiphene citrate. Hypothalamic hormonal modulation therapy with clomiphene citrate may become a new preventive choice for trigeminal autonomic cephalalgias. The possible mechanism of action of clomiphene citrate for cluster headache prevention will be discussed.
Rozen
Todd
T
Michigan Head Pain and Neurological Institute, Ann Arbor, MI 48104, USA.
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D003027:Cluster Headache / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male
D004965:Estrogen Antagonists; D002996:Clomiphene