Dolasetron-induced torsades de pointes.
A 52-year-old woman with hypertension and Graves' disease was scheduled for surgical removal of a meningioma. Intraoperative events were significant for hypotension requiring a vasopressin infusion. Prophylactic dolasetron was administered to the patient before emergence. The patient's trachea was easily extubated and she was neurologically intact at the end of the surgical procedure. On transport to the neurological intensive care unit, the patient developed torsades de pointes, requiring cardiopulmonary resuscitation, before a return to normal sinus rhythm.
Turner
Sarah
S
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. thesooner@aol.com
Mathews
Letha
L
Pandharipande
Pratik
P
Thompson
Reid
R
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000638:Amiodarone / Q000008:administration & dosage; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage / Q000009:adverse effects*; D016887:Cardiopulmonary Resuscitation; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007022:Hypotension / Q000188:drug therapy; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects*; D007431:Intraoperative Complications / Q000188:drug therapy; D007442:Intubation, Intratracheal; D008577:Meningeal Neoplasms / Q000601:surgery*; D008579:Meningioma / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy; D011412:Propanolamines / Q000008:administration & dosage; D011807:Quinolizines / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D016171:Torsades de Pointes / Q000139:chemically induced*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D014667:Vasopressins / Q000008:administration & dosage
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000932:Antiemetics; D007211:Indoles; D011412:Propanolamines; D011807:Quinolizines; D014662:Vasoconstrictor Agents; D014667:Vasopressins; C060344:dolasetron; C036604:esmolol; D000638:Amiodarone