Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine.
Phenothiazine can be incorporated as a redox-active probe into DNA in two conceptually different ways: the non-nucleosidic DNA base surrogate exhibits similar properties to 10-methylphenothiazine but with no preferential base-pairing properties, whereas the phenothiazine-modified uridine has different optical and electrochemical properties, but exhibits preferred Watson-Crick base pairing with adenine.
Wagner
Clemens
C
University of Regensburg, Institute for Organic Chemistry, D-93040, Regensburg, Germany.
Wagenknecht
Hans-Achim
HA
D001482:Base Composition; D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D004563:Electrochemistry; D055095:Optics and Photonics; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000737:chemistry*; D044366:Transition Temperature
C511996:5-(10-methyl-phenothiazin-3-yl)-2'-deoxyuridine; D010640:Phenothiazines; C045775:N-methylphenothiazine; D004247:DNA; C031637:phenothiazine; D003857:Deoxyuridine