title: Initial clinical experience with real-time transrectal ultrasonography-magnetic resonance imaging fusion-guided prostate biopsy.
abstract: OBJECTIVE
  To evaluate the feasibility and utility of registration and fusion of real-time transrectal ultrasonography (TRUS) and previously acquired magnetic resonance imaging (MRI) to guide prostate biopsies.
  
  
  METHODS
  Two National Cancer Institute trials allowed MRI-guided (with or with no US fusion) prostate biopsies during placement of fiducial markers. Fiducial markers were used to guide patient set-up for daily external beam radiation therapy. The eligible patients had biopsy-confirmed prostate cancer that was visible on MRI. A high-field (3T) MRI was performed with an endorectal coil in place. After moving to an US suite, the patient then underwent TRUS to visualize the prostate. The US transducer was equipped with a commercial needle guide and custom modified with two embedded miniature orthogonal five-degrees of freedom sensors to enable spatial tracking and registration with MR images in six degrees of freedom. The MRI sequence of choice was registered manually to the US using custom software for real-time navigation and feedback. The interface displayed the actual and projected needle pathways superimposed upon the real-time US blended with the prior MR images, with position data updating in real time at 10 frames per second. The registered MRI information blended to the real-time US was available to the physician who performed targeted biopsies of highly suspicious areas.
  
  
  RESULTS
  Five patients underwent limited focal biopsy and fiducial marker placement with real-time TRUS-MRI fusion. The Gleason scores at the time of enrollment on study were 8, 7, 9, 9, and 6. Of the 11 targeted biopsies, eight showed prostate cancer. Positive biopsies were found in all patients. The entire TRUS procedure, with fusion, took approximately 10 min.
  
  
  CONCLUSIONS
  The fusion of real-time TRUS and prior MR images of the prostate is feasible and enables MRI-guided interventions (like prostate biopsy) outside of the MRI suite. The technique allows for navigation within dynamic contrast-enhanced maps, or T2-weighted or MR spectroscopy images. This technique is a rapid way to facilitate MRI-guided prostate therapies such as external beam radiation therapy, brachytherapy, cryoablation, high-intensity focused ultrasound ablation, or direct injection of agents, without the cost, throughput, or equipment compatibility issues that might arise with MRI-guided interventions inside the MRI suite.
authors: Radiation Medicine Department, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. anurag.singh@roswellpark.org
authors: Anurag K
authors: AK
authors: Singh
authors: Jochen
authors: J
authors: Kruecker
authors: Sheng
authors: S
authors: Xu
authors: Neil
authors: N
authors: Glossop
authors: Peter
authors: P
authors: Guion
authors: Karen
authors: K
authors: Ullman
authors: Peter L
authors: PL
authors: Choyke
authors: Bradford J
authors: BJ
authors: Wood
mesh_terms: D001707:Biopsy, Needle / Q000379:methods; D005240:Feasibility Studies; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D018084:Ultrasonography, Interventional / Q000379:methods