CSF histamine levels in rats reflect the central histamine neurotransmission.
Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels, we measured the levels in rats across 24h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data.
Soya
Atsushi
A
Sleep and Circadian Neurobiology Laboratory, Center for Narcolepsy, Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Palo Alto, CA 94304, USA.
Song
You Hwi
YH
Kodama
Tohru
T
Honda
Yoshiko
Y
Fujiki
Nobuhiro
N
Nishino
Seiji
S
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D005508:Food Deprivation / Q000502:physiology; D006632:Histamine / Q000134:cerebrospinal fluid*; D008297:Male; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012892:Sleep Deprivation / Q000378:metabolism / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D010880:Piperidines; D006632:Histamine; D000661:Amphetamine; C052075:thioperamide; D000077408:Modafinil