Chronology of the HIV-1 CRF07_BC expansion in East Asia.
The HIV-1 epidemic among injecting drug users (IDU) in Taiwan is caused primarily by CRF07_BC infections. Evolutionary analyses, which utilize outgroup reference strains from northwestern China (Xinjiang), reveal that CRF07_BC was introduced into southern Taiwan in 1998-2001 and spread to central-northern Taiwan in 2001-2003, causing the largest HIV/AIDS epidemic in Taiwan. The separate introduction of CRF07_BC into Xinjiang occurred in 1992-1995. This study illustrates the temporal dynamics of CRF07_BC spread among IDU across east Asia.
Tee
Kok Keng
KK
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Pybus
Oliver G
OG
Liao
Huanan
H
Uenishi
Rie
R
Hase
Saiki
S
Kamarulzaman
Adeeba
A
Li
Xiao-Jie
XJ
Takebe
Yutaka
Y
D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005814:Genes, Viral / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1 / Q000235:genetics; D010802:Phylogeny; D015819:Substance Abuse, Intravenous; D013624:Taiwan / Q000453:epidemiology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics
D054299:env Gene Products, Human Immunodeficiency Virus