Prostaglandin E2: making more of your marrow.
We have recently demonstrated through a chemical screen in the zebrafish embryo that prostaglandin E2 (PGE2) is an evolutionarily conserved regulator of hematopoietic stem cell (HSC) number. These results have further been confirmed by in vitro and in vivo studies in the murine model. Bioactive PGE2 derivatives have potential clinical application to accelerate recovery of the hematopoietic system following chemotherapy or irradiation. Ex vivo expansion of HSCs prior to stem cell transplantation may improve reconstitution of hematopoiesis and immune function. This article aims to summarize current knowledge of PGE2-mediated regulation of blood cell homeostasis as well as to discuss the proposed use of PGE2 to expand hematopoietic stem cells for transplantation in the clinical setting.
Lord
Allegra M
AM
Stem Cell Program and Hematology/Oncology, Children's Hospital and Dana- Farber Cancer Institute, HHMI, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
North
Trista E
TE
Zon
Leonard I
LI
D000818:Animals; D001853:Bone Marrow; D015232:Dinoprostone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D051379:Mice; D015398:Signal Transduction; D015027:Zebrafish
D015232:Dinoprostone