title: Quinolone alkaloids from Waltheria douradinha.
abstract: A phytochemical investigation of the stems of Waltheria douradinha resulted in isolation of two 4-quinolone alkaloids, waltherione B and vanessine, along with three known alkaloids, waltherione A, antidesmone and O-methyltembamide. Their structures were elucidated on the basis of their 2D NMR spectroscopic analyses, and from X-ray crystallographic analysis of waltherione A and the O-methyl derivative of waltherione B. Additionally, waltherione B and vanessine, and the O- and N-methyl derivatives of waltherione A and waltherione B, were evaluated for their antimicrobial activities; only vanessine displayed any (weak) antimicrobial activity.
authors: Departamento de Química (NPPN), Universidade Federal de Santa Maria, Santa Maria RS, Brazil.
authors: Vanessa
authors: V
authors: Gressler
authors: Caroline Z
authors: CZ
authors: Stüker
authors: Gilvan de O C
authors: Gde O
authors: Dias
authors: Ionara I
authors: II
authors: Dalcol
authors: Robert A
authors: RA
authors: Burrow
authors: Juergen
authors: J
authors: Schmidt
authors: Ludger
authors: L
authors: Wessjohann
authors: Ademir F
authors: AF
authors: Morel
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D001372:Aza Compounds / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D010936:Plant Extracts; D011804:Quinolines; D015363:Quinolones; C471325:antidesmone; C502881:waltherione-A