1,5-anhydroglucitol (GlycoMark) as a marker of short-term glycemic control and glycemic excursions.
1,5-anhydroglucitol (1,5-AG) is a validated marker of short-term glycemic control. It is a metabolically inert polyol that competes with glucose for reabsorption in the kidneys. Otherwise stable levels of 1,5-AG are rapidly depleted as blood glucose levels exceed the renal threshold for glucosuria. 1,5-AG more accurately predicts rapid changes in glycemia than hemoglobin A1C (A1C) or fructosamine. It is also more tightly associated with glucose fluctuations and postprandial glucose. Thus, 1,5-AG may offer complementary information to A1C. This review will summarize the limitations of current methods of assessing glycemic control, assess the data to support 1,5-AG as a glycemic marker and highlight the scenarios by which 1,5-AG may fill the gap in assessing glycemic control.
Dungan
Kathleen M
KM
Ohio State University, 4th Floor McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, USA. kathleen.dungan@osumc.edu
D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D003847:Deoxyglucose / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D019518:Postprandial Period
D015415:Biomarkers; D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose