New alpha,gamma-cyclic peptides-nanotube molecular caps using alpha,alpha-dialkylated alpha-amino acids.
We report here the preparation and structural characteristics of a novel self-assembling peptide composed of alternating alpha,alpha-dialkylated alpha-amino and cis-4-aminocyclopent-2-enecarboxylic acids. The use of alpha,alpha-dialkylated amino acids represents a novel method to prevent the formation of extensive beta-sheet-like hydrogen-bonding networks that are characteristic of peptide nanotubes.
D000478:Alkylation; D000596:Amino Acids / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D045333:Nanotubes, Peptide / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*
D000596:Amino Acids; D045333:Nanotubes, Peptide; D010456:Peptides, Cyclic; D006859:Hydrogen