Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers.
Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximately 10(-8) M) than for conventional surfactants and block copolymers.
D001709:Biotechnology / Q000379:methods*; D002138:Calibration; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008956:Models, Chemical; D010316:Particle Size; D020959:Polyethylene / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013053:Spectrophotometry / Q000379:methods; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D013501:Surface-Active Agents; D014867:Water; D020959:Polyethylene