[Score prediction of metastatic risk in Gastrointestinal Stromal Tumours (GIST)].
The purpose was to generate a score targeted at the metastatic risk potentially reflecting oncogenic activation in Gastrointestinal Stromal Tumours (GIST). In 41 patients size and location of the primary, mitotic index, initial symptoms, and histological appearance were rated with 0 to 1 or 2 points. The course of the disease was recorded as incidental, symptomatic, locally recurrent, with peritoneal dissemination, or with hepatic spread. The parameters tumour size (p < 0.001), mitotic index (p < 0.001), localisation of the primary (p < 0.001) and symptoms (p < 0.05) correlated with the course of the disease. This correlation was highly significant (p << 0.0005) when the overall score was applied, the median being 0 in incidental, 3 in symptomatic, 4 in locally recurrent, 4.5 in peritoneal, and 5 points in hepatic spreading GIST. Results were compared with those of an established risk stratification. The sensitivity and specificity of a score > 4 for the occurrence of liver metastases were 100 and 73.5 % compared with 85.7 and 82.4 % for a high risk profile according to Franquemont's classification. The results indicate the ability of routinely recorded data to predict the metastatic outcome of GIST.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D041981:Gastrointestinal Tract / Q000473:pathology / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D011379:Prognosis; D012107:Research Design; D012307:Risk Factors; D015996:Survival Rate; D047368:Tumor Burden
Entwicklung eines Malignitätsscores zur Vorhersage der Metastasierungswahrscheinlichkeit Gastrointestinaler Stromatumoren (GIST).