Pain additivity, diffuse noxious inhibitory controls, and attention: a functional measurement analysis.
This study utilized the methodology of Functional Measurement theory to investigate the additivity of painful and non-painful thermally induced experiences at one body site with those produced by brief noxious and innocuous electrical stimuli at another. Forty healthy young subjects were tested, using a Peltier thermode to induce tonic pain and an electrocutaneous stimulator for presenting phasic pain, under conditions of either full attention or visual/cognitive distraction (counting numerous light signals) in order to evaluate whether the summed effects are attributable to refocused attention. Six levels of intensity were combined in a factorial design for both tonic and phasic pain. Subjects indicated the overall strength of their dual perception on a visual analog scale. Stimuli showed complex patterns of interaction. Two stimuli were generally rated as greater than one, but the summation was far from additive and greatly influenced by the intensity of the stronger stimulus, suggesting inhibitory action. In general, tonic heat pain strongly affected the perception of phasic electrocutaneous pain whereas the reverse was only partly true. Distraction had a very small effect, suggesting that the "pain inhibits pain" phenomenon attributable to diffuse noxious inhibitory controls (DNIC) is not due to attentional processes. Our data also relate to issues regarding spatial summation across dermatomes and to adaptation level effects in pain, in which a strong painful experience serves as an anchor or comparison point by which others are judged. The psychophysical findings provide a perceptual foundation for clinical phenomena in which patients face with comorbid pain disorders.
D000222:Adaptation, Physiological / Q000502:physiology*; D000223:Adaptation, Psychological / Q000502:physiology*; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology / Q000523:psychology*; D011582:Psychological Theory; D011601:Psychophysics; D012016:Reference Values; D011984:Sensory Receptor Cells / Q000502:physiology; D012737:Sex Factors; D012867:Skin / Q000294:innervation