Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban.
The complete 1H and 13C NMR assignments are reported for the antithrombotic (21R)- and (21S)-argatroban by 1D and 2D NMR experiments (HSQC, HMBC, NOESY and 1H--1H COSY). Some well-resolved signals could be used for an accurate measurement of the diastereomeric composition of argatroban.
D001120:Arginine / Q000031:analogs & derivatives; D002247:Carbon Isotopes; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010875:Pipecolic Acids / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013449:Sulfonamides
D002247:Carbon Isotopes; D005343:Fibrinolytic Agents; D010875:Pipecolic Acids; D013449:Sulfonamides; D006859:Hydrogen; D001120:Arginine; C031942:argatroban