The effect of diet on the susceptibility of the mouse to pneumonia virus of mice; influence of pyridoxine administered in the period before as well as after the inoculation of virus.
Young mice fed diets deficient in pyridoxine for 8 days or longer before the inoculation of PVM, as well as after inoculation, were more susceptible to infection than control mice fed complete diets. Young mice fed a pyridoxine-deficient diet gained weight as well as controls fed a complete diet for 5 weeks, but they lost weight in the 6th week. The ratio of thymus or spleen weight to body weight was less in mice fed a pyridoxine-deficient diet for 6 weeks than in controls fed a complete diet. Histologically the thymuses and spleens showed hypoplasia. No measurable difference in antibodies against PVM was found in the sera of uninoculated mice fed complete or pyridoxine-deficient diets for 6 weeks.
D000818:Animals; D001835:Body Weight; D004032:Diet; D004198:Disease Susceptibility; D051379:Mice; D029122:Murine pneumonia virus; D011014:Pneumonia; D011736:Pyridoxine; D013154:Spleen; D014611:Vaccination
D011736:Pyridoxine
PNEUMONIA/experimental