Structural determination of two new sesquiterpenes biotransformed from germacrone by Mucor alternata.
Eight transformed sesquiterpenes of germacrone by Mucor alternata were obtained. Their structures were characterized on the basis of spectral methods including 2D NMR. Among them, (1S, 4S, 5S, 10R)-isozedoarondiol (2) and (1R, 4S, 5S, 10R)-diepoxy-12-hydroxygermacrone (3) are new compounds.
D001711:Biotransformation; D030024:Curcuma / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D008968:Molecular Conformation; D009089:Mucor / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D045788:Sesquiterpenes, Germacrane; C048393:germacrone