Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy.
BACKGROUND
The purpose of this study was to determine the influence of weight loss on outcome in patients with head and neck cancer undergoing concomitant chemoradiotherapy (CCRT): treatment interruption, infections, mortality, and hospital readmission rate.


METHODS
Forty patients with head and neck cancer were enrolled. All patients were counseled to follow a nutritional program during CCRT. Body weight was evaluated at baseline, at the end, and 30 days after radiochemotherapy.


RESULTS
Ninety percent of compliant patients with nutritional program maintained body weight (mean, 1 +/- 2.4 kg) and 100% of noncompliant patients continued to lose weight (mean, -9 +/- 4 kg; p < .001). A reduction greater than 20% of prediagnosis weight significantly correlated with treatment interruption (p = .003), infections (p = .002), early mortality (p = .011), hospital readmission rate (p = .001), and survival (log-rank test: z = -2.722, p = .006).


CONCLUSIONS
In patients with head and neck cancer undergoing CCRT, the early nutritional management reduces weight loss and improve outcome.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications; D002177:Candidiasis / Q000150:complications; D003376:Counseling; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D009752:Nutritional Status; D018529:Nutritional Support; D017063:Outcome Assessment, Health Care; D010349:Patient Compliance; D010359:Patient Readmission / Q000706:statistics & numerical data; D011228:Prealbumin / Q000032:analysis; D016019:Survival Analysis; D015431:Weight Loss
D011228:Prealbumin