title: Interleukin 1 beta gene polymorphism and risk of cervical cancer.
abstract: OBJECTIVE
  To determine whether a polymorphism at position +3953 in exon 5 of the lL-1beta gene (IL-1beta +3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer.
  
  
  METHODS
  We isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1beta +3953 allele polymorphism was determined by polymerase chain reaction.
  
  
  RESULTS
  Genotypes A1/A2 and A2/A2+A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78-4.67; P<0.001 and OR, 2.85; 95% CI, 1.77-4.6; P<0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61-12.50; P<0.001) compared with a nonsmoker with the A1/A1 genotype.
  
  
  CONCLUSIONS
  This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer.
authors.affiliation: Department of Biotechnology, Panjab University, Chandigarh, India. rcsobti@pu.ac.in
authors.forename: Ranbir Chander
authors.initials: RC
authors.lastname: Sobti
authors.forename: Dor Mohammad
authors.initials: DM
authors.lastname: Kordi Tamandani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shekari
authors.forename: Pushpinder
authors.initials: P
authors.lastname: Kaur
authors.forename: Keyanoosh
authors.initials: K
authors.lastname: Malekzadeh
authors.forename: Vanita
authors.initials: V
authors.lastname: Suri
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta