A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.
BACKGROUND
Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.


METHODS
Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.


RESULTS
(1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).


CONCLUSIONS
The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D009041:Motion Sickness / Q000139:chemically induced / Q000503:physiopathology; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D010507:Periodicity; D013270:Stomach / Q000502:physiology*; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced / Q000503:physiopathology
D014667:Vasopressins