title: [The cancer stem cell: the breast cancer driver].
abstract: Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/low lin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
authors.affiliation: University of Michigan Medical Center, Comprehensive Cancer Center, Int Med-Hematology/Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA. cginesti@umich.edu
authors.forename: Christophe
authors.initials: C
authors.lastname: Ginestier
authors.forename: Hasan
authors.initials: H
authors.lastname: Korkaya
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dontu
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.forename: Max S
authors.initials: MS
authors.lastname: Wicha
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Charafe-Jauffret
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D015703:Antigens, CD / Q000032:analysis; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology*; D002455:Cell Division; D018450:Disease Progression; D005260:Female; D006801:Humans; D013234:Stem Cells / Q000201:enzymology / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D000444:Aldehyde Dehydrogenase
vernacular_title: La cellule souche cancéreuse: un pilote aux commandes du cancer du sein.