title: Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.
abstract: This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.
authors.affiliation: Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. edith.mitchell@jefferson.edu
authors.forename: Edith P
authors.initials: EP
authors.lastname: Mitchell
authors.forename: Roman
authors.initials: R
authors.lastname: Perez-Soler
authors.forename: Eric
authors.initials: E
authors.lastname: Van Cutsem
authors.forename: Mario E
authors.initials: ME
authors.lastname: Lacouture
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000068818:Cetuximab; D003875:Drug Eruptions / Q000503:physiopathology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000069347:Erlotinib Hydrochloride; D006201:Hair Diseases / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D000077341:Lapatinib; D009260:Nail Diseases / Q000139:chemically induced / Q000503:physiopathology; D000077544:Panitumumab; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011799:Quinazolines / Q000009:adverse effects; D013684:Telangiectasis / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000077341:Lapatinib; D000077544:Panitumumab; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors; D000068818:Cetuximab