title: Anatomic correlates of a normal perfusion scan using 64-slice computed tomographic coronary angiography.
abstract: Both myocardial perfusion imaging (MPI) and multislice computed tomography (MSCT) are currently used to detect coronary artery disease (CAD). However, MSCT permits early detection of atherosclerosis while myocardial perfusion is still normal. In addition, MPI results can be normal despite the presence of high-risk CAD (left main and balanced 3-vessel CAD). In this study, the range of anatomic findings using MSCT in patients with normal MPI results was evaluated. In 180 patients presenting with chest pain, MPI (with gated single-photon emission computed tomography) and 64-slice MSCT were performed. In patients with normal MPI results, prevalences of completely normal coronary arteries, nonobstructive CAD, and obstructive CAD were determined using MSCT. The occurrence of high-risk CAD, including left main and 3-vessel disease, was also evaluated. Normal MPI and adequate MSCT findings were obtained in 97 patients (54%; 50% women; average age 58 +/- 12 years; 5% with known CAD). A total of 38 patients (39%) showed normal coronary anatomy, whereas nonsignificant and significant CAD were observed in 37 (38%) and 18 patients (19%), respectively. Importantly, only 4 patients (4%) presented with high-risk CAD using 64-slice MSCT, 2 with left main and 2 with 3-vessel disease. In conclusion, a normal MPI result can be associated with a wide range of anatomic observations and cannot exclude the presence of both nonobstructive and obstructive CAD. However, importantly, the prevalence of high-risk CAD was rare.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. j.m.van_werkhoven@lumc.nl
authors.forename: Jacob M
authors.initials: JM
authors.lastname: van Werkhoven
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.forename: Lucia J
authors.initials: LJ
authors.lastname: Kroft
authors.forename: Marcel P M
authors.initials: MP
authors.lastname: Stokkel
authors.forename: Petra
authors.initials: P
authors.lastname: Dibbets-Schneider
authors.forename: Gabija
authors.initials: G
authors.lastname: Pundziute
authors.forename: Arthur J H A
authors.initials: AJ
authors.lastname: Scholte
authors.forename: Ernst E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D000241:Adenosine; D002316:Cardiotonic Agents; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000175:diagnosis; D004280:Dobutamine; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014665:Vasodilator Agents
chemical_list: D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D004280:Dobutamine; D000241:Adenosine