Renal pelvic hemorrhage and acute renal failure associated with carboplatin therapy.
A 44-year-old woman with ovarian cancer and normal renal function developed gross hematuria after carboplatin therapy. Laboratory investigation revealed elevated blood urea nitrogen and serum creatinine values. Computed tomography scan of the abdomen and pelvis with or without contrast revealed bilateral hydronephrosis with high-attenuation material within the left renal pelvis and both ureters consistent with blood. Delayed images at 3 hours revealed intense nephrogram with delayed excretion of contrast bilaterally. She underwent cystoscopy and placement of ureteral stent bilaterally. She had brisk diuresis with associated progressive decrease in serum creatinine to baseline value.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D005260:Female; D006417:Hematuria / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007682:Kidney Pelvis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D016190:Carboplatin