title: Cyclo(Dehydrohistidyl-L-tryptophyl), an inhibitor of nitric oxide production from a fungal strain, Fb956.
abstract: In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-Ltryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an IC50 of 6.5 muM in activated BV-2 cells. The structure determination and biological activity of cyclo(dehydrohistidyl- L-tryptophyl) was reported for the first time in this study.
authors.affiliation: Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Noh
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Hyung-Eun
authors.initials: HE
authors.lastname: Yu
authors.forename: Ick-Dong
authors.initials: ID
authors.lastname: Yoo
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D010456:Peptides, Cyclic; D009569:Nitric Oxide