title: Cortical and brainstem LTP-like plasticity in Huntington's disease.
abstract: Recent studies have reported abnormalities in short-term plasticity in patients with Huntington's disease (HD). However, is not known whether long-term potentiation (LTP)-like plasticity is also affected in these patients. We tested cortical and brainstem LTP-like plasticity in eight symptomatic HD patients and in 10 healthy age-matched controls. To probe motor cortex LTP-like plasticity we used paired associative stimulation (PAS), a technique that combines repetitive electric stimulation of the median nerve with subsequent transcranial magnetic stimulation (TMS) of the contralateral motor cortex at 25 ms. To investigate brainstem plasticity, we induced LTP-like phenomena in the trigeminal wide dynamic range neurons (WDR) of the blink reflex circuit by pairing an high-frequency train of electrical stimuli (HFS) over the right supraorbital nerve (SO) coincident with the R2 response elicited by a preceding SO stimulus. Our results demonstrate impairment of both cortical and brainstem LTP-like plasticity in symptomatic HD patients which is similar to LTP deficits previously reported in HD animal models. These findings might well represent the neurophysiological correlates of memory deficits often present in HD.
authors.affiliation: CUNY School of Medicine, Department of Physiology and Pharmacology, New York, NY, USA.
authors.forename: Domenica
authors.initials: D
authors.lastname: Crupi
authors.forename: Maria Felice
authors.initials: MF
authors.lastname: Ghilardi
authors.forename: Clara
authors.initials: C
authors.lastname: Mosiello
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Rocco
authors.forename: Angelo
authors.initials: A
authors.lastname: Quartarone
authors.forename: Fortunato
authors.initials: F
authors.lastname: Battaglia
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001767:Blinking / Q000528:radiation effects; D001933:Brain Stem / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation; D004569:Electroencephalography / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology / Q000528:radiation effects; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008475:Median Nerve / Q000503:physiopathology / Q000528:radiation effects; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology / Q000528:radiation effects; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D050781:Transcranial Magnetic Stimulation