title: Effect of mifepristone on the expression of endometrial secretory leukocyte protease inhibitor in new medroxyprogesterone acetate users.
abstract: The effect of mifepristone on the expression of secretory leukocyte protease inhibitor (SLPI) in the endometrium of women using depot medroxyprogesterone acetate (DMPA) was investigated in this randomized, placebo-controlled trial. The study showed that the administration of DMPA led to a substantial inhibition of endometrial SLPI protein and mRNA, and that the addition of mifepristone to DMPA-exposed endometrium partially restored the expression of glandular SLPI.
authors.affiliation: Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Aimin
authors.initials: A
authors.lastname: Li
authors.forename: Juan C
authors.initials: JC
authors.lastname: Felix
authors.forename: Wangrong
authors.initials: W
authors.lastname: Yang
authors.forename: John K
authors.initials: JK
authors.lastname: Jain
mesh_terms: D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage; D004347:Drug Interactions; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D015870:Gene Expression / Q000528:radiation effects; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D015735:Mifepristone / Q000378:metabolism*; D015990:Placebo Effect; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000378:metabolism*
chemical_list: D003271:Contraceptive Agents, Female; D003280:Contraceptives, Oral, Synthetic; D053481:Secretory Leukocyte Peptidase Inhibitor; D015735:Mifepristone; D017258:Medroxyprogesterone Acetate