[Preheparin lipoprotein lipase mass and apolipoproteinC-III ratio helps identify postprandial triglyceride metabolic marker].
Serum lipid profiles have usually been evaluated using blood specimen in fasting state. However, postprandial hypertriglyceridemia is important risk factor for atherosclerosis. In the present study, we determined several parameters of triglyceride (TG) metabolism in healthy volunteers. Serum concentrations of TG in fasting state correlated negative the ratio of preheparin serum lipoprotein lipase mass (pLPL) and apoC-III (pLPL/apoC-III) in both fasting (r = -0.771, p < 0.0001) and postprandial (r = -0.640, p < 0.0001) state. To exclude the effect of high density lipoprotein (HDL) in serum, we purified the fraction of TG rich lipoprotein (TRL) using ultracentrifugation method 3 healthy volunteers with postprandial state. The pLPL/apoC-III was reduced constantly during postprandial state in all volunteers. These findings suggest that pLPL/apoC-III may be a useful marker for evaluation of TG metabolism using postprandial blood specimens.
D000328:Adult; D053305:Apolipoprotein C-III / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005215:Fasting / Q000378:metabolism; D006493:Heparin; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis* / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000378:metabolism*; D014461:Ultracentrifugation
D053305:Apolipoprotein C-III; D015415:Biomarkers; D014280:Triglycerides; D006493:Heparin; D008071:Lipoprotein Lipase