title: The role of partial nephrectomy for the management of sporadic renal angiomyolipoma.
abstract: OBJECTIVE
  Angiomyolipoma is a benign renal tumor that has a propensity to grow over time and may cause local complications. Given the benign nature of these lesions, renal-preserving treatments are favored. We evaluated our experience with nephron-sparing surgery for renal angiomyolipoma.
  
  
  METHODS
  We reviewed our institutional nephrectomy registry to identify patients treated with nephron-sparing surgery for renal angiomyolipoma between 1970 and 2004. Patients with a diagnosis of tuberous sclerosis were excluded. Patient demographics, perioperative complications, and postoperative outcomes were recorded.
  
  
  RESULTS
  We identified 58 patients treated with nephron-sparing surgery for sporadic renal angiomyolipoma, including 44 women and 14 men. The median tumor size was 3.9 cm (range, 0.8-12.5 cm). In 7 patients (12%), several ipsilateral angiomyolipomas were resected, whereas 2 patients were treated with nephron-sparing surgery for bilateral angiomyolipomas. The overall early complication rate was 12%, including a urine leak in 3 (5%) patients. At a median postoperative follow-up of 8 years (range, 1-31 years), 2 (3.4%) patients had radiographic evidence of local recurrence, although no patient experienced symptom recurrence. The median preoperative serum creatinine level was 1.0 mg/dL (range, 0.5-3.9 mg/dL), and the median creatinine level at last follow-up was 1.1 mg/dL (range, 0.6-3.6 mg/dL). No patient developed de novo chronic renal insufficiency after nephron-sparing surgery, including 4 patients treated for angiomyolipomas in a solitary kidney.
  
  
  CONCLUSIONS
  Nephron-sparing surgery for sporadic renal angiomyolipomas offers preservation of renal function and is associated with acceptable complication and low local recurrence rates. The results of this study support nephron-sparing surgery for these lesions.
authors.affiliation: Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boorjian
authors.forename: Igor
authors.initials: I
authors.lastname: Frank
authors.forename: Brant
authors.initials: B
authors.lastname: Inman
authors.forename: Christine M
authors.initials: CM
authors.lastname: Lohse
authors.forename: John C
authors.initials: JC
authors.lastname: Cheville
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Leibovich
authors.forename: Michael L
authors.initials: ML
authors.lastname: Blute
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018207:Angiomyolipoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D011183:Postoperative Complications