title: The effects of type 1 diabetes on cerebral white matter.
abstract: OBJECTIVE
  Studies investigating the structure, neurophysiology and functional outcomes of white matter among type 1 diabetes patients have given conflicting results. Our aim was to investigate the relationship between type 1 diabetes and white matter hyperintensities.
  
  
  METHODS
  We assessed white matter integrity (using magnetic resonance imaging), depressive symptoms and neuropsychological function in 114 type 1 diabetes patients and 58 age-matched non-diabetic controls.
  
  
  RESULTS
  Only Fazekas grade 1 and 2 white matter hyperintensities were found among 114 long-duration, relatively young diabetes patients; the severity of lesions did not differ substantially from 58 healthy controls. White matter hyperintensities were not associated with depressive history or with clinical characteristics of diabetes, including retinopathy, severe hypoglycaemia or glycaemia control.
  
  
  CONCLUSIONS
  Our data do not support an association between diabetes characteristics and white matter hyperintensities among relatively young type 1 diabetes participants.
authors.affiliation: Behavioral and Mental Health Research Joslin Diabetes Center, One Joslin Place Suite 350, Boston, MA 02459, USA. katie.weinger@joslin.harvard.edu
authors.forename: K
authors.initials: K
authors.lastname: Weinger
authors.forename: A M
authors.initials: AM
authors.lastname: Jacobson
authors.forename: G
authors.initials: G
authors.lastname: Musen
authors.forename: I K
authors.initials: IK
authors.lastname: Lyoo
authors.forename: C M
authors.initials: CM
authors.lastname: Ryan
authors.forename: D C
authors.initials: DC
authors.lastname: Jimerson
authors.forename: P F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001921:Brain / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008055:Lipids / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values
chemical_list: D008055:Lipids