Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration.
This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.
D053523:Amelogenin / Q000502:physiology; D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D002478:Cells, Cultured; D002999:Clone Cells; D003789:Dental Pulp Exposure / Q000503:physiopathology; D003804:Dentin / Q000502:physiology*; D003809:Dentin, Secondary / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D058574:Integrin-Binding Sialoprotein; D051379:Mice; D009804:Odontoblasts / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology; D051381:Rats; D012038:Regeneration / Q000502:physiology*; D012795:Sialoglycoproteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D053523:Amelogenin; C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; C546871:IBSP protein, human; C546872:Ibsp protein, mouse; C546873:Ibsp protein, rat; D058574:Integrin-Binding Sialoprotein; C487705:MEPE protein (242-264), human; D010446:Peptide Fragments; D012795:Sialoglycoproteins; D016212:Transforming Growth Factor beta