title: Emerging aspects of membrane traffic in neuronal dendrite growth.
abstract: Polarized growth of the neuron would logically require some form of membrane traffic to the tip of the growth cone, regulated in conjunction with other trafficking processes that are common to both neuronal and non-neuronal cells. Unlike axons, dendrites are endowed with membranous organelles of the exocytic pathway extending from the cell soma, including both rough and smooth endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment (ERGIC). Dendrites also have satellite Golgi-like cisternal stacks known as Golgi outposts that have no membranous connections with the somatic Golgi. Golgi outposts presumably serve both general and specific local trafficking needs, and could mediate membrane traffic required for polarized dendritic growth during neuronal differentiation. Recent findings suggest that dendritic growth, but apparently not axonal growth, relies very much on classical exocytic traffic, and is affected by defects in components of both the early and late secretory pathways. Within dendrites, localized processes of recycling endosome-based exocytosis regulate the growth of dendritic spines and postsynaptic compartments. Emerging membrane traffic processes and components that contribute specifically to dendritic growth are discussed.
authors.affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore. bchtbl@nus.edu.sg
authors.forename: Bor Luen
authors.initials: BL
authors.lastname: Tang
mesh_terms: D000818:Animals; D001692:Biological Transport; D003712:Dendrites / Q000378:metabolism*; D005089:Exocytosis; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D021601:trans-Golgi Network / Q000378:metabolism