[Local ultrasound hyperthermia as a component of radiotherapy for osteogenic sarcoma of tubular bones in children and adolescents].
An evaluation of the end results of combined treatment for osteogenic sarcoma by standard chemoradiotherapy (n = 66) and novel thermochemical therapy (n = 108) using local ultrasound hyperthermia (total number--174) demonstrated their dependence on the temperature range in target tumor tissues. Use of subhypertemperatures of 39--41-45 deg.C (TTD--36 Gy) did not improve the results of treatment. However, 41-45 deg.C (TTD--36 Gy) was followed by a significant increase in 3- and 5-year survival and improved quality of life in cured patients as compared with those receiving standard radiotherapy (TTD--60-110 Gy). Hyperthermic therapeutic effect in osteogenic sarcoma depends on certain conditions. Effective temperatures can generally be reached in patients with relatively large-size tumors and rather thin coats of subcutaneous fat.
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional