title: Fragment-based ligand discovery meets phage display.
abstract: In a powerful complement to traditional ligand discovery methods such as high-throughput screening, fragment-based ligand discovery methods identify ligands piece by piece. A recent advance combines the concepts of fragment-based ligand discovery with phage-display technology to yield bivalent kinase inhibitors with high potency and specificity.
authors.affiliation: Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, California 94080, USA. erlanson@sunesis.com
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Erlanson
mesh_terms: D008024:Ligands; D019151:Peptide Library; D047428:Protein Kinase Inhibitors / Q000737:chemistry
chemical_list: D008024:Ligands; D019151:Peptide Library; D047428:Protein Kinase Inhibitors