title: Sulbactam-containing beta-lactamase inhibitor combinations.
abstract: Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum beta-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce class I (Ampc) chromosomal beta-lactamases in Enterobacteriaceae.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey. makova@hacettepe.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Akova
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D002438:Cefoperazone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D004338:Drug Combinations; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D002438:Cefoperazone; D013407:Sulbactam