title: Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?
abstract: Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.
authors.affiliation: Laboratory of Immunology, Brest University Medical School Hospital, Brest, France; Unit of Rheumatology, Brest,University Medical School Hospital, Brest, France.
authors.forename: Aymeric
authors.initials: A
authors.lastname: Binard
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Le Pottier
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.forename: Valérie
authors.initials: V
authors.lastname: Devauchelle-Pensec
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
mesh_terms: D000818:Animals; D015551:Autoimmunity; D053264:B-Cell Activating Factor / Q000276:immunology / Q000378:metabolism*; D053265:B-Cell Activation Factor Receptor / Q000276:immunology / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor