title: Biological properties and functional determinants of the urotensin II receptor.
abstract: The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT.
authors.affiliation: Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, J1H 5N4 Canada.
authors.forename: Christophe D
authors.initials: CD
authors.lastname: Proulx
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Holleran
authors.forename: Pierre
authors.initials: P
authors.lastname: Lavigne
authors.forename: Emanuel
authors.initials: E
authors.lastname: Escher
authors.forename: Gaétan
authors.initials: G
authors.lastname: Guillemette
authors.forename: Richard
authors.initials: R
authors.lastname: Leduc
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014579:Urotensins / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled; D014579:Urotensins; C029677:urotensin II