title: Giant cell tumor of the spine.
abstract: Giant cell tumors are benign but locally aggressive neoplasms that typically affect the extremities. When involving the spine, the tumors occur predominantly in the sacrum. Gross total resection of the tumor with wide margins yields good results in terms of survival. However, it carries a significant potential for morbidity and disability. Subtotal resection with adjuvant radiation carries a risk for recurrence or, more concerning, sarcomatous malignant transformation. Endovascular tumor embolizations have also been attempted to control unresectable tumors, and have been performed with moderate degrees of success. Outcomes are analyzed outcomes following surgery, radiation therapy, and tumor embolization.
authors.affiliation: Department of Neurological Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital/Cornell, Room A-969, 525 East 68th Street, New York, NY 10021, USA.
authors.forename: Neal
authors.initials: N
authors.lastname: Luther
authors.forename: Mark H
authors.initials: MH
authors.lastname: Bilsky
authors.forename: Roger
authors.initials: R
authors.lastname: Härtl
mesh_terms: D004621:Embolization, Therapeutic / Q000379:methods; D018212:Giant Cell Tumor of Bone / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000628:therapy; D019635:Neurosurgical Procedures / Q000379:methods; D011878:Radiotherapy / Q000379:methods; D013117:Spinal Cord Compression / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D013125:Spinal Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D013131:Spine / Q000473:pathology* / Q000503:physiopathology; D016896:Treatment Outcome