[Lighting effect on spontaneous tumor development in female rats].
The investigation is concerned with effects of lighting--12hr light/12hr dark (standard), natural lighting in the Russian North-West, constant illumination and light deprivation--on life span and spontaneous tumor development in female LIO rats. Constant and North-West lighting involved premature aging, shorter mean (13.5 and 25%) and maximum life span (by 9 and 7 months, respectively) and a significant increase in spontaneous tumor development rate as compared with standard lighting. Light deprivation resulted in a longer maximum life span and significant (2.1 times) drop in tumor incidence.
D000375:Aging; D000818:Animals; D003624:Darkness; D005260:Female; D008027:Light / Q000009:adverse effects*; D008029:Lighting / Q000009:adverse effects*; D008136:Longevity; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000209:etiology; D010507:Periodicity; D051381:Rats