[Extent of destructive changes in tumor parenchyma of breast cancer patients of various age].
Extent of viable tumor parenchyma and necrotic tissue as well as grade of tumor cell apoptosis were assessed using histological samples from 377 patients with invasive ductal carcinoma of the breast. No preoperative chemo- or radiotherapy was given. Patients of varying age were examined for destructive changes in tumor nodes both in absence and presence of regional metastases. The highest viability was registered in patients aged 30-39 years. There was a reverse correlation between age, on the one hand, and extent of intact tumor parenchyma, on the other. Similarly, the same age group revealed relatively pronounced destructive changes such as necrosis and apoptosis which are generally characteristic of younger age. There was a significant relationship between extent of destructive changes and malignant anaplasia.
D000328:Adult; D000367:Age Factors; D000368:Aged; D017209:Apoptosis; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis