title: Genetic support of extended-spectrum beta-lactamases.
abstract: Genes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are mostly either TEM or SHV derivatives, CTX-M-like enzymes--now emerging worldwide--or, less frequently, VEB, GES, and PER ESBLs. The mechanisms responsible for their acquisition are very diverse, and mostly are related to insertion sequences (ISs), transposons, class 1 integrons, and also sul1-type integrons containing the ISCR1 element. This diversity of genetic vehicles at the origin of these mobilisation/acquisition processes enhances the spread of ESBLs.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, South-Paris Medical School, University Paris XI, Le Kremlin-Bicêtre, France. laurent.poirel@bct.aphp.fr
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: T
authors.initials: T
authors.lastname: Naas
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006801:Humans; D032023:Integrons / Q000235:genetics*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D001618:beta-Lactamases