[Experimental and clinical grounds for using 30% solution of ethyl alcohol for chemical denervation of the gastric acid-producing zone].
Experiments were performed in 18 male rats followed by a histological investigation of the obtained material. The application of the 30% solution of ethyl alcohol was proved to cause irreversible dystrophic alterations of nerve fibers in the gastric wall when injected subserously and there were no irreversible destructive alterations in other organ tissues. Results of treatment of 82 patients with perforated pyloro-duodenal ulcers after suturing the perforated opening in combination with chemical denervation of the gastric acid-producing zone with 30% solution of ethyl alcohol injected subserously were analyzed. Reliably decreased acid-proteolytic activity of the gastric body was found to result in stable remission and low percentage of recurrent diseases. The method can be recommended for wide practical use due to its simplicity and low percentage of recurrences of ulcer disease of the duodenum against the background of preserved helicobacteriosis of the stomach.
D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D010439:Peptic Ulcer Perforation / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012189:Retrospective Studies; D013270:Stomach / Q000294:innervation*; D013276:Stomach Ulcer / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D013563:Sympathectomy, Chemical / Q000379:methods*; D016896:Treatment Outcome; D014630:Vagus Nerve / Q000187:drug effects*
D000431:Ethanol