title: Cryptococcosis masquerading as a tuboovarian abscess.
abstract: This report describes a 25-year-old human immunodeficiency virus- seropositive patient who initially presented with clinical features of a tuboovarian abscess. After a poor response to antibiotic therapy, laparotomy and excision of a right-sided, unilocular, pseudocystic ovarian mass measuring 140 x 80 x 60 mm were undertaken. Mucoid gelatinous material, with a glistening appearance and slimy consistency, coated the inner surface of the thick wall. The cyst contained clear, viscid fluid with a similar slimy consistency. Although the macroscopic diagnosis was that of an ovarian mucinous cystadenocarcinoma, histopathologic assessment confirmed a well-circumscribed pseudocystic cryptococcoma with a wall of granulation and fibrous tissue and compressed ovarian stroma. The inner surface was covered by large, paucireactive, extracellular "yeast lakes" of carminophilous Cryptococcus neoformans yeasts of varying shape and size. To the best of our knowledge, this is the first documentation of ovarian cryptococcosis in the English language literature. Despite their rarity in the female genital tract, fungal infections must be considered in the differential diagnosis of patients presenting with pelvic pain of obscure origin and a pelvic mass that is refractory to antibiotic therapy.
authors.affiliation: Department of Anatomical Pathology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, National Health Laboratory Service, Durban, KwaZulu-Natal, South Africa. ramdial@ukzn.ac.za
authors.forename: Yetish
authors.initials: Y
authors.lastname: Sing
authors.forename: Pratistadevi K
authors.initials: PK
authors.lastname: Ramdial
authors.forename: Tasnim
authors.initials: T
authors.lastname: Ibrahim
mesh_terms: D000038:Abscess / Q000209:etiology / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology; D003937:Diagnosis, Differential; D005184:Fallopian Tube Diseases / Q000382:microbiology / Q000473:pathology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D010048:Ovarian Cysts / Q000382:microbiology* / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology; D010052:Ovariectomy; D000292:Pelvic Inflammatory Disease / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole