[The cancer stem cell: the breast cancer driver].
Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/low lin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D015703:Antigens, CD / Q000032:analysis; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology*; D002455:Cell Division; D018450:Disease Progression; D005260:Female; D006801:Humans; D013234:Stem Cells / Q000201:enzymology / Q000473:pathology*
D015703:Antigens, CD; D000444:Aldehyde Dehydrogenase
La cellule souche cancéreuse: un pilote aux commandes du cancer du sein.