[Means of improvement of surgical treatment for oropharyngeal planocellular carcinoma].
A new technique of intraoperative bolus-assisted administration of chemical drugs for oropharyngeal carcinoma has been developed. In tongue tumor, the lingual artery was ligated at the site of origin from the external carotid artery and catheter was installed after venous flow was blocked. Bolus was used to administer 5-fluorouracyl intraoperatively before and after removal of primary tumor. The external carotid artery was ligated at a site above the origin of the upper thyroid artery after venous flow was blocked and paracervical fat excised when tumor site was at the back of the oral cavity, oropharynx or in cases of locally advanced cancer. Subsequently, depending on tumor site, catheter was installed into the external carotid artery trunk at a site below the origin of the lingual artery, the external carotid artery was ligated once more at a site above the origin of the facial artery, and bolus was used to administer 5-fluorouracyl intraoperatively before and after removal of primary tumor. According to the end results, relapse occurred after 28 months instead of 12 and survival improved within the first 2 years after surgery.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007269:Injections, Intra-Arterial; D019647:Oral Surgical Procedures / Q000379:methods*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome
D002945:Cisplatin; D005472:Fluorouracil