title: Carcinoma of the breast; possible significance of menstrual cycle in results of operation.
abstract: Among 55 patients upon whom mastectomy was done for cancer of the breast, survival without evidence of metastasis (after varying periods of follow-up) was significantly higher for those who were operated upon in the seven days preceding the beginning of menses than it was for those who underwent operation in any of the three other seven-day periods in the menstrual cycle. Moreover, in a comparison of results of operations done in each of the four seven-day periods, there was a graduating increase in mortality and metastasis from the first period (the seven days preceding menses) through the fourth period. The results of the study of this small series are considered not conclusive but indicative of possible profit in studies of larger and better controlled series.
authors.forename: F R
authors.initials: FR
authors.lastname: RUFF
mesh_terms: D000328:Adult; D001940:Breast; D001943:Breast Neoplasms; D002277:Carcinoma; D005260:Female; D006801:Humans; D008408:Mastectomy; D008597:Menstrual Cycle; D008598:Menstruation; D008875:Middle Aged
keywords: BREAST/cancer