title: To QC or not to QC: the key to a consistent laboratory?
abstract: A limiting factor in every embryology laboratory is its capacity to grow 'normal' embryos. In human in vitro fertilisation (IVF), there is considerable awareness that the environment of the laboratory itself can alter the quality of the embryos produced and the industry as a whole has moved towards the implementation of auditable quality management systems. Furthermore, in some countries, such as Australia, an established quality management system is mandatory for clinical IVF practice, but such systems are less frequently found in other embryology laboratories. Although the same challenges of supporting consistent and repeatable embryo development are paramount to success in all embryology laboratories, it could be argued that they are more important in a research setting where often the measured outcomes are at an intracellular or molecular level. In the present review, we have outlined the role and importance of quality control and quality assurance systems in any embryo laboratory and have highlighted examples of how simple monitoring can provide consistency and avoid the induction of artefacts, irrespective of the laboratory's purpose, function or species involved.
authors.affiliation: Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5000, Australia. michelle.lane@adelaide.edu.au
authors.forename: Michelle
authors.initials: M
authors.lastname: Lane
authors.forename: Megan
authors.initials: M
authors.lastname: Mitchell
authors.forename: Kara S
authors.initials: KS
authors.lastname: Cashman
authors.forename: Deanne
authors.initials: D
authors.lastname: Feil
authors.forename: Sarah
authors.initials: S
authors.lastname: Wakefield
authors.forename: Deirdre L
authors.initials: DL
authors.lastname: Zander-Fox
mesh_terms: D000641:Ammonia; D000818:Animals; D001755:Blastocyst / Q000166:cytology; D003470:Culture Media; D046149:Embryo Culture Techniques / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D004626:Embryology; D047108:Embryonic Development; D005307:Fertilization in Vitro; D006801:Humans; D007753:Laboratories / Q000592:standards*; D051379:Mice; D011786:Quality Control
chemical_list: D003470:Culture Media; D000641:Ammonia