title: [Initiation factors eIF4: from sea urchin embryonic development to chronic lymphocytic leukemia].
abstract: mRNA translation is now recognized as a important regulatory step for gene expression in different physiological and pathophysiological processes including cell proliferation and apoptosis. B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of resting lymphocytes and defective apoptosis. The mRNA cap-binding protein eIF4E (eukaryotic Initiation Factor 4E) and its repressor 4E-BP (eIF4E Binding protein) are crucial translational regulators that have been involved in survival and apoptosis processes of cells. We have shown that the release of eIF4E from its translational repressor 4E-BP is an important event for the first mitotic division triggered by fertilization and that the degradation of 4E-BP is a new means to regulate 4E-BP function that has to be analyzed in other physiological and physiopathological processes. In this chapter, we describe recent advances illustrating the importance of eIF4E and 4E-BP in cancer processes, suggesting that these actors can be targeted for potential therapy against cancer in general and LLC in particular.
authors.affiliation: Centre National de la Recherche Scientifique, UMR 7150 Mer & Santé, France. saad@sb-roscoff.fr
authors.forename: Hussam
authors.initials: H
authors.lastname: Saad
authors.forename: Robert
authors.initials: R
authors.lastname: Bellé
authors.forename: Julia
authors.initials: J
authors.lastname: Morales
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cosson
authors.forename: Odile
authors.initials: O
authors.lastname: Mulner-Lorillon
authors.forename: Christian
authors.initials: C
authors.lastname: Berthou
authors.forename: Patrick
authors.initials: P
authors.lastname: Cormier
mesh_terms: D017209:Apoptosis; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008957:Models, Genetic; D009865:Oocytes / Q000502:physiology; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D010443:Peptide Chain Termination, Translational; D010448:Peptide Initiation Factors / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; C075833:eIF-4
vernacular_title: Facteurs d'initiation eIF4: du développement embryonnaire de l'oursin à la leucémie lymphoïde chronique.