[Effect of apolipoprotein A-1 containing steroid hormones on DNA and protein biosynthesis in cells of ascitic hepatoma HA-1].
The rate of DNA and protein biosynthesis in murine hepatoma HA-1 was accelerated when steroid hormones, containing a reduced delta4,3-keto group in the A-ring, were used in combination with apolipoprotein A-1. That was demonstrated for apolipoprotein A-1 complexes with dehydroepiandrosterone, dehydroepiandrosterone sulfate and tetrahydrocortisol. Apolipoprotein A-1 complexes serve as a vehicle for steroids penetration into cells to influence protein biosynthesis.
D016632:Apolipoprotein A-I / Q000378:metabolism*; D001201:Ascites / Q000209:etiology*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D004273:DNA, Neoplasm; D003687:Dehydroepiandrosterone / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics; D013256:Steroids / Q000378:metabolism*; D013760:Tetrahydrocortisol / Q000378:metabolism
D016632:Apolipoprotein A-I; D004273:DNA, Neoplasm; D006728:Hormones; D013256:Steroids; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D013760:Tetrahydrocortisol