title: Oral undifferentiated high-grade pleomorphic sarcoma: report of a case.
abstract: The current World Health Organization classification considers the existence of an undifferentiated unclassifiable category of pleomorphic sarcomas, defined as a group of pleomorphic high-grade sarcomas. Undifferentiated high-grade pleomorphic sarcoma represents about 5% of all soft tissue sarcomas in adults and occurs more commonly in the extremities. In the oral cavity, undifferentiated pleomorphic sarcoma is extremely rare. We report a case of undifferentiated high-grade pleomorphic sarcoma located in the floor of the mouth in a man 56 years old. Microscopically, spindle-shaped cells with accented pleomorphism arranged in a storiform pattern, several bizarre giant cells, and frequent atypical mitoses were observed. The tumor cells were positive only for vimentin, with focal positivity for CD68. The patient was treated by surgery and postoperative radiation therapy, and after 25 months, no recurrence was observed.
authors.affiliation: School of Dentistry, University of Ribeirao Preto, Ribeirao Preto and São Paulo, Brazil. ysousa@unaerp.br
authors.forename: Edson
authors.initials: E
authors.lastname: Alfredo
authors.forename: Joubert Magalhães
authors.initials: JM
authors.lastname: de Pádua
authors.forename: Eduardo Luis
authors.initials: EL
authors.lastname: Vicentini
authors.forename: Melissa Andreia
authors.initials: MA
authors.lastname: Marchesan
authors.forename: Raphael Carlos
authors.initials: RC
authors.lastname: Comelli Lia
authors.forename: Danyel Elias
authors.initials: DE
authors.lastname: da Cruz Perez
authors.forename: Yara Teresinha Corrêa
authors.initials: YT
authors.lastname: Silva-Sousa
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology* / Q000601:surgery; D009062:Mouth Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy; D012509:Sarcoma / Q000145:classification / Q000473:pathology* / Q000628:therapy; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule