title: Early donor management increases the retrieval rate of lungs for transplantation.
abstract: BACKGROUND
  Lung transplantation activity is frustrated by donor lung availability. We sought to examine the effect of active donor management and hormone administration on pulmonary function and yield in cadaveric heart-beating potential lung donors.
  
  
  METHODS
  We studied 182 potential lung donors (arterial oxygen tension [PaO2]/fractional inspired oxygen [FIO2] ratio > or = 230). From this group, 60 patients (120 lungs) were allocated, within a randomized trial, to receive methylprednisolone (1 g), triiodothyronine (0.8 microg/kg bolus and 0.113 microg/kg/h infusion), both methylprednisolone and triiodothyronine, or placebo as soon as feasible after consent and initial assessment. Trial donors underwent protocol-guided optimization of ventilation and hemodynamics, lung water assessment, and bronchoscopy. Function was assessed by PaO2/FIO2 ratio, extravascular lung water index (EVLWI), and pulmonary vascular resistance (PVR). A nontrial group of 122 donors (244 lungs) received similar management without bronchoscopy, pulmonary artery flotation catheter monitoring, or lung water assessment.
  
  
  RESULTS
  Within the trial, management commenced within a median of 2 hours (interquartile range, 0.5 to 3.5 hours) of consent and continued for an average of 6.9 +/- 1.2 hours. The PaO2/FIO2 ratio deteriorated (p = 0.028) from 397 +/- 78 (95% CL, 376 to 417) to 359 +/- 126 (95% CL, 328 to 390) and EVLWI from 9.7 +/- 4.5 mL/kg (95% CL, 8.6 to 10.9 mL/kg) to 10.8 +/- 5.2 mL/kg (95% CL, 9.4 to 12.2 mL/kg; p = 0.009). PVR remained unchanged (p = 0.28). At end management, 48 of 120 trial lungs (40%) were transplanted versus 66 of 244 nontrial lungs (27%; p = 0.016). Neither methylprednisolone and triiodothyronine nor T3 increased lung yield or affected PaO2/FIO2 or EVLWI; however, methylprednisolone attenuated the increase in EVLWI (p = 0.009).
  
  
  CONCLUSIONS
  Early active management of lung donors increases yield. Steroid administration reduces progressive lung water accumulation.
authors.affiliation: Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
authors.forename: Rajamiyer V
authors.initials: RV
authors.lastname: Venkateswaran
authors.forename: Val B
authors.initials: VB
authors.lastname: Patchell
authors.forename: Ian C
authors.initials: IC
authors.lastname: Wilson
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Mascaro
authors.forename: Richard D
authors.initials: RD
authors.lastname: Thompson
authors.forename: David W
authors.initials: DW
authors.lastname: Quinn
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockley
authors.forename: John H
authors.initials: JH
authors.lastname: Coote
authors.forename: Robert S
authors.initials: RS
authors.lastname: Bonser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001926:Brain Death; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008168:Lung / Q000187:drug effects; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D015999:Multivariate Analysis; D009926:Organ Preservation / Q000379:methods*; D011336:Probability; D012016:Reference Values; D015427:Reperfusion Injury / Q000517:prevention & control*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000592:standards* / Q000639:trends; D006113:United Kingdom
chemical_list: D008775:Methylprednisolone