title: Synthesis of an anthrose derivative and production of polyclonal antibodies for the detection of anthrax spores.
abstract: A straightforward synthesis of a derivative of anthrose, the non-reducing terminal fragment of the antigenic tetrasaccharide from Bacillus anthracis, was achieved starting from d-galactose. This hapten is able to induce a highly specific and sensitive immune response in rabbit when attached to a carrier protein.
authors.affiliation: Laboratoire des Glucides UMR-CNRS 6219, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 rue Saint-Leu, F-80039 Amiens, France.
authors.forename: Sandrine G Y
authors.initials: SG
authors.lastname: Dhénin
authors.forename: Vincent
authors.initials: V
authors.lastname: Moreau
authors.forename: Nathalie
authors.initials: N
authors.lastname: Morel
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Nevers
authors.forename: Hervé
authors.initials: H
authors.lastname: Volland
authors.forename: Christophe
authors.initials: C
authors.lastname: Créminon
authors.forename: Florence
authors.initials: F
authors.lastname: Djedaïni-Pilard
mesh_terms: D000606:Amino Sugars / Q000138:chemical synthesis*; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001408:Bacillus anthracis / Q000276:immunology*; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006433:Hemocyanins / Q000276:immunology; D007124:Immunoenzyme Techniques / Q000379:methods; D011817:Rabbits; D013171:Spores, Bacterial / Q000737:chemistry / Q000276:immunology*
chemical_list: C504007:4,6-dideoxy-4-(3-hydroxy-3-methylbutanamido)-2-O-methylglucopyranose; D000606:Amino Sugars; D000907:Antibodies, Bacterial; D006433:Hemocyanins; D003847:Deoxyglucose; C032808:keyhole-limpet hemocyanin