title: Comparison of FDG-PET, PET/CT and MRI for follow-up of colorectal liver metastases treated with radiofrequency ablation: initial results.
abstract: OBJECTIVE
  Morphologic imaging after radiofrequency ablation (RFA) of liver metastases is hampered by rim-like enhancement in the ablation margin, making the identification of local tumor progression (LTP) difficult. Follow-up with PET/CT is compared to follow-up with PET alone and MRI after RFA.
  
  
  METHODS
  Sixteen patients showed 25 FDG-positive colorectal liver metastases in pre-interventional PET/CT. Post-interventional PET/CT was performed 24h after ablation and was repeated after 1, 3 and 6 months and then every 6 months. PET and PET/CT data were compared with MR data sets acquired within 14 days before or after these time points. Either histological proof by biopsy or resection, or a combination of contrast-enhanced CT at fixed time points and clinical data served as a reference.
  
  
  RESULTS
  The 25 metastases showed a mean size of 20mm and were treated with 39 RFA sessions. Ten lesions which developed LTP received a second round of RFA; four lesions received three rounds of treatment. The mean follow-up time was 22 months. Seventy-two PET/CT and 57 MR examinations were performed for follow-up. The accuracy and sensitivity for tumor detection was 86% and 76% for PET alone, 91% and 83% for PET/CT and 92% and 75% for MRI, respectively.
  
  
  CONCLUSIONS
  In comparison to PET alone, PET/CT was significantly better for detecting LTP after RFA. There were no significant differences between MRI and PET/CT. These preliminary results, however, need further verification.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D 45122 Essen, Germany. Electronic address: hilmar.kuehl@uni-due.de.
authors.forename: Hilmar
authors.initials: H
authors.lastname: Kuehl
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D 45122 Essen, Germany.
authors.forename: Gerald
authors.initials: G
authors.lastname: Antoch
authors.affiliation: Clinic for Nuclear Medicine; University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Stergar
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D 45122 Essen, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Veit-Haibach
authors.affiliation: Clinic for Nuclear Medicine; University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rosenbaum-Krumme
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D 45122 Essen, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Vogt
authors.affiliation: Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Frilling
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D 45122 Essen, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Barkhausen
authors.affiliation: Clinic for Nuclear Medicine; University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18