title: A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.
abstract: BACKGROUND
  Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.
  
  
  METHODS
  Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.
  
  
  RESULTS
  (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).
  
  
  CONCLUSIONS
  The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.
authors.affiliation: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Geng-Qing
authors.initials: GQ
authors.lastname: Song
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Hou
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Qian
authors.forename: J D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D009041:Motion Sickness / Q000139:chemically induced / Q000503:physiopathology; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D010507:Periodicity; D013270:Stomach / Q000502:physiology*; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D014667:Vasopressins