title: MIPS: analysis and annotation of genome information in 2007.
abstract: The Munich Information Center for Protein Sequences (MIPS-GSF, Neuherberg, Germany) combines automatic processing of large amounts of sequences with manual annotation of selected model genomes. Due to the massive growth of the available data, the depth of annotation varies widely between independent databases. Also, the criteria for the transfer of information from known to orthologous sequences are diverse. To cope with the task of global in-depth genome annotation has become unfeasible. Therefore, our efforts are dedicated to three levels of annotation: (i) the curation of selected genomes, in particular from fungal and plant taxa (e.g. CYGD, MNCDB, MatDB), (ii) the comprehensive, consistent, automatic annotation employing exhaustive methods for the computation of sequence similarities and sequence-related attributes as well as the classification of individual sequences (SIMAP, PEDANT and FunCat) and (iii) the compilation of manually curated databases for protein interactions based on scrutinized information from the literature to serve as an accepted set of reliable annotated interaction data (MPACT, MPPI, CORUM). All databases and tools described as well as the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de).
authors.affiliation: Institute for Bioinformatics (MIPS), German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.
authors.forename: H W
authors.initials: HW
authors.lastname: Mewes
authors.forename: S
authors.initials: S
authors.lastname: Dietmann
authors.forename: D
authors.initials: D
authors.lastname: Frishman
authors.forename: R
authors.initials: R
authors.lastname: Gregory
authors.forename: G
authors.initials: G
authors.lastname: Mannhaupt
authors.forename: K F X
authors.initials: KF
authors.lastname: Mayer
authors.forename: M
authors.initials: M
authors.lastname: Münsterkötter
authors.forename: A
authors.initials: A
authors.lastname: Ruepp
authors.forename: M
authors.initials: M
authors.lastname: Spannagl
authors.forename: V
authors.initials: V
authors.lastname: Stümpflen
authors.forename: T
authors.initials: T
authors.lastname: Rattei
mesh_terms: D030562:Databases, Protein; D005656:Fungal Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D016681:Genome, Fungal; D018745:Genome, Plant; D023281:Genomics; D020407:Internet; D010940:Plant Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D025941:Protein Interaction Mapping; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
chemical_list: D005656:Fungal Proteins; D010940:Plant Proteins