[Effectiveness of different regimes of combined treatment (cisplatin+ radiotherapy) for intraoral and oropharyngeal cancer].
Three regimes of combined treatment for intraoral and oropharyngeal cancer were compared. In group A, cisplatin 6 mg/m2 was given intravenously, daily; group B--40 mg/m2, weekly; group C--100 mg/m2, once in 3 weeks. All patients simultaneously received distant radiation therapy in a standard fractionated dose of 2 Gy per fraction, 5 times a week, up to TTD of 68-70 Gy. Among relatively frequent side-effects were granulocytopenia, asthenia and stomatitis. Overall immediate effectiveness was: group A--100%, group B--96% and group C--100%. The rates of complete tumor resorption were: group A--27.3%, group B--19.2% and group C--16.7%.
D000328:Adult; D000380:Agranulocytosis / Q000209:etiology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001247:Asthenia / Q000209:etiology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D018714:Radiotherapy, Adjuvant; D013280:Stomatitis / Q000209:etiology; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin