title: The complete genome sequence of the Atlantic salmon paramyxovirus (ASPV).
abstract: The complete RNA genome of the Atlantic salmon paramyxovirus (ASPV), isolated from Atlantic salmon suffering from proliferative gill inflammation (PGI), has been determined. The genome is 16,965 nucleotides in length and consists of six nonoverlapping genes in the order 3'- N - P/C/V - M - F - HN - L -5', coding for the nucleocapsid, phospho-, matrix, fusion, hemagglutinin-neuraminidase and large polymerase proteins, respectively. The gene junctions contain highly conserved transcription start and stop signal sequences and trinucleotide intergenic regions similar to those of other Paramyxoviridae. The ASPV P-gene expression strategy is like that of the respiro- and morbilliviruses, which express the phosphoprotein from the primary transcript, and edit a portion of the mRNA to encode the accessory proteins V and W. It also encodes the C-protein by ribosomal choice of translation initiation. Pairwise comparisons of amino acid identities, and phylogenetic analysis of deduced ASPV protein sequences with homologous sequences from other Paramyxoviridae, show that ASPV has an affinity for the genus Respirovirus, but may represent a new genus within the subfamily Paramyxovirinae.
authors.affiliation: Department of Biology, University of Bergen, N-5020, Norway. Stian.Nylund@bio.uib.no
authors.forename: Stian
authors.initials: S
authors.lastname: Nylund
authors.forename: Marius
authors.initials: M
authors.lastname: Karlsen
authors.forename: Are
authors.initials: A
authors.lastname: Nylund
mesh_terms: D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D005393:Fish Diseases / Q000821:virology*; D016679:Genome, Viral; D005880:Gills / Q000166:cytology / Q000821:virology; D008969:Molecular Sequence Data; D018184:Paramyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D018098:Paramyxovirinae / Q000145:classification* / Q000235:genetics; D010802:Phylogeny; D020317:Salmo salar / Q000821:virology*; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014764:Viral Proteins