title: The spleen's role in transplantation immunology.
abstract: While graft rejection has been studied for many years, recent investigations have focused on the generation and maintenance of transplantation tolerance. This review examines the role of secondary lymphoid organs, especially the spleen, characterizes the maintenance mechanism that is key to the development of tolerance and explores the implications of new strategies for inducing tolerance in transplantation.
authors.affiliation: Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. haramasa@med.miyazaki-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Hara
authors.forename: Eiichi
authors.initials: E
authors.lastname: Chosa
authors.forename: Toshio
authors.initials: T
authors.lastname: Onitsuka
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D013154:Spleen / Q000276:immunology*; D014181:Transplantation Immunology; D023001:Transplantation Tolerance / Q000276:immunology