title: Transperineal ultrasound-guided saturation biopsies using 11-region template of prostate: report of 303 cases.
abstract: OBJECTIVE
  To assess the prostate cancer detection rate and safety of transperineal ultrasound-guided saturation biopsies of the prostate using an 11-region template of the gland in a Chinese screening population.
  
  
  METHODS
  A total of 303 patients (mean age, 69.7 years) were prospectively enrolled in this study to undergo an 11-region template-guided transperineal saturation biopsy of the prostate. The inclusion criteria included a prostate-specific antigen level of 4.0 ng/mL or greater, suspicious findings on the digital rectal examination, or abnormal prostate gland findings on ultrasonography, computed tomography, or magnetic resonance imaging. The median prostate-specific antigen level was 13.7 ng/mL (range, 0.2 to 100), and the median prostate volume was 47.0 cm3 (range, 7 to 190).
  
  
  RESULTS
  A mean of 23.7 cores (range, 11 to 44) were obtained, with an overall prostate cancer detection rate of 37.6% (114 of 303). The cancer detection rate in the groups with a prostate-specific antigen level of 0 to 4.0, 4.1 to 10.0, 10.1 to 20.0, 20.1 to 30.0, 30.1 to 70.0, and greater than 70.1 ng/mL was 22.2% (4 of 18), 8.2% (6 of 73), 21.6% (22 of 102), 48.4% (15 of 31), 68.4% (26 of 38), and 100% (41 of 41), respectively. No serious complications occurred during the procedure.
  
  
  CONCLUSIONS
  Transperineal ultrasound-guided saturation biopsy of the prostate is safe and feasible. Moreover, the application of an 11-region template of the prostate resulted in an encouraging cancer detection rate.
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Li
authors.forename: Weigang
authors.initials: W
authors.lastname: Yan
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Ji
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D018084:Ultrasonography, Interventional
chemical_list: D017430:Prostate-Specific Antigen