title: Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.
abstract: OBJECTIVE
  Ventricular fibrillation (VF) is a possible consequence of brief myocardial ischemia. Such a short ischemia does not provoke cell damage, but induces changes in intracellular cardiac metabolism due to diminished oxygen supply to the heart. Trimetazidine (TMZ) is a drug able to restore the metabolic balance between fatty acid and glucose oxidation in ischemic myocardial cells. The aim of this double-blind study was to investigate TMZ effect on VF in pigs during short-term ischemia.
  
  
  METHODS
  Ischemia was induced after thoracotomy by complete, but brief (1 min) occlusion of the left anterior descending coronary artery under electrical stimulation. The ventricular fibrillation threshold (VFT), heart rate (HR), various hemodynamic parameters and malondialdehyde (MDA) blood levels were measured before and during ischemia in two groups of eight anesthetized pigs. The mass of ischemic myocardial tissue was also evaluated.
  
  
  RESULTS
  No effects on either the HR or the hemodynamic parameters were observed during myocardial ischemia, whereas TMZ increased the VFT and decreased both MDA blood levels (an index of lipid peroxidation) and the ischemic area.
  
  
  CONCLUSIONS
  TMZ limited ischemia-induced electrical dysfunction leading to cardiac susceptibility to VF by decreasing lipid peroxidation and maintaining ionic homeostasis. TMZ could therefore provide protection against ischemia-induced VF.
authors.affiliation: Laboratoire de Pharmacologie Médicale, Faculté de Médecine Grange-Blanche, INSERM ERI 22, Université Claude Bernard Lyon-I, 8 avenue Rockefeller, 69373, Lyon cedex 08, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Vaillant
authors.forename: Panayota
authors.initials: P
authors.lastname: Tsibiribi
authors.forename: Giampiero
authors.initials: G
authors.lastname: Bricca
authors.forename: Bernard
authors.initials: B
authors.lastname: Bui-Xuan
authors.forename: Anne
authors.initials: A
authors.lastname: Bescond-Jacquet
authors.forename: Alain
authors.initials: A
authors.lastname: Tabib
authors.forename: Jacques
authors.initials: J
authors.lastname: Descotes
authors.forename: Quadiri
authors.initials: Q
authors.lastname: Timour
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate; D006706:Homeostasis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D017202:Myocardial Ischemia / Q000150:complications*; D013552:Swine; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
chemical_list: D014665:Vasodilator Agents; D008315:Malondialdehyde; D014292:Trimetazidine