title: Upper limb function after intrathecal baclofen treatment in children with cerebral palsy.
abstract: BACKGROUND
  The literature shows that intrathecal baclofen (ITB) treatment in patients with cerebral palsy (CP) is able to reduce spasticity. The purpose of this work is to evaluate the motor function of the upper limbs in patients with CP treated with ITB.
  
  
  METHODS
  A consecutive series of 20 patients with spastic CP (mean age at implant, 11.4 years) implanted with pumps in our center was studied. These patients were classified using the Gross Motor Function Classification System. The patients were followed up over a 12-month period for assessment of the upper limb function with the Melbourne Assessment of Unilateral Upper Limb Function scale.
  
  
  RESULTS
  The data show a reduction of upper limb spasticity in all 20 patients (P < 0.05). The Melbourne scale shows a statistically significant improvement of the total score (P < 0.05) and an improvement of the subskills of range of movement, target accuracy, and fluency. Twenty-five percent of patients showed a clinically significant improvement.
  
  
  CONCLUSIONS
  The subjects with CP of different degrees of severity had an improvement in the quality of the upper limb function and showed overall satisfaction with the results achieved. The study also shows the importance of evaluating the quality of upper limb function in children with CP treated with ITB therapy.
authors.affiliation: Department of Paediatric Orthopaedics, V Buzzi Children's Hospital, Milan, Italy. f.motta@icp.mi.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Motta
authors.forename: Cecilia
authors.initials: C
authors.lastname: Stignani
authors.forename: Clara E
authors.initials: CE
authors.lastname: Antonello
mesh_terms: D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage*; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal / Q000295:instrumentation; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D016059:Range of Motion, Articular / Q000502:physiology*; D012189:Retrospective Studies; D016896:Treatment Outcome; D034941:Upper Extremity / Q000503:physiopathology*
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen