title: Incidence of primary liver cancer in Italy between 1988 and 2002: an age-period-cohort analysis.
abstract: We conducted in Italy a study to evaluate trends of primary liver cancer (PLC) and to disentangle the period from birth-cohort effects on PLC incidence. Cases aged<80 years and diagnosed between 1988 and 2002 in 20 areas covered by population-based Cancer Registries were included. Age-standardised incidence rates and age-period-cohort effects were estimated. In 1998-2002, incidence rates of PLC were 21.1/100,000 men and 6.0/100,000 women. In both genders, incidence rates increased slightly between 1988-1992 and 1993-1997 but did not rise thereafter. Amongst men, PLC risk increased in every cohort born after 1913 and the rise became steeper for cohorts born in 1948. In women, an upward trend appeared only in the cohorts born after 1953. Incidence of PLC over the last two decades in Italy did not substantially change but huge geographical variability emerged, mainly due to different times and modalities of spread of hepatitis C virus.
authors.affiliation: Epidemiology and Biostatistics Unit, Aviano Cancer Center, IRCCS, Via Franco Gallini 2, 33081 Aviano (PN), Italy. epidemiology@cro.it
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Mauro
authors.initials: M
authors.lastname: Lise
authors.forename: Paola
authors.initials: P
authors.lastname: Zambon
authors.forename: Emanuele
authors.initials: E
authors.lastname: Crocetti
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Fulvio
authors.initials: F
authors.lastname: Ricceri
authors.forename: Marina
authors.initials: M
authors.lastname: Vercelli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Lisi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tagliabue
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
authors.forename: Fabio
authors.initials: F
authors.lastname: Falcini
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cassetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Donato
authors.forename: Mario
authors.initials: M
authors.lastname: Fusco
authors.forename: Mario
authors.initials: M
authors.lastname: Budroni
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferretti
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Silvano
authors.initials: S
authors.lastname: Piffer
authors.forename: Francesco
authors.initials: F
authors.lastname: Bellù
authors.forename: Lucia
authors.initials: L
authors.lastname: Mangone
authors.forename: Adriano
authors.initials: A
authors.lastname: Giacomin
authors.forename: Susanna
authors.initials: S
authors.lastname: Vitarelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged