[Steatohepatitis and cirrhosis: first manifestation 23 years after jejunoileal bypass surgery].
Intestinal shunting procedures followed by gastrointestinal bypass surgery have been used as therapeutic modalities in the treatment of morbid obesity since the mid 1950s. Enthusiasm reached its peak in the early 1960s with the introduction of the jejunoileal bypass, however began to wane as various complications were identified in the remote postoperative period and later. Finally, the jejunoileal bypass was abandoned in the 1980s. Apart from renal disorders, it frequently resulted in abnormal liver function and liver failure which are attributed to fatty infiltration. We report a 56-year-old woman, who underwent jejunoileal bypass surgery 23 years ago. She was admitted to our ICU because of hepatic encephalopathy IV, caused by upper gastrointestinal bleeding. Beside hepatic encephalopathy there were signs of severe liver failure (INR 2.8, cholesterol 32 mg/dl, ICG PDR 5%). Liver biopsy showed fatty infiltration and cirrhosis. Excluding other causes of liver disease, severe fatty liver disease following jejunoileal bypass surgery was diagnosed. The very late onset of severe liver disease emphasizes the importance of lifelong follow-up of these patients.
D005234:Fatty Liver / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged
Steatohepatitis und Leberzirrhose: Erstmanifestation 23 Jahre nach Jejunoilealem Bypass.