title: A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis.
abstract: OBJECTIVE
  There is growing epidemiological literature focusing on the bidirectional association between psychosocial factors and atopic disorders, but no efforts to quantify the relationship systematically have been published.
  
  
  METHODS
  We searched Medline, PsycINFO, Web of Science, and PubMed up to June 2007. The studies included were prospective cohort studies investigating the influence of psychosocial factors on atopic disorders and the effect of atopic disorders on mental health. Two investigators independently extracted data and determined study quality.
  
  
  RESULTS
  There were 43 studies (in 22 articles), of which 34 evaluated the effect of psychosocial factors on atopic disorders and 9 evaluated the effect of atopic disorders on mental health. The major atopic disease assessed in these studies was asthma (90.7%) with allergic rhinitis, 4.7%; atopic dermatitis, 2.3%; and food allergies, 2.3%. The overall meta-analysis exhibited a positive association between psychosocial factors and future atopic disorder (correlation coefficient (r) as combined size effect .024; 95% confidence interval, 0.014-0.035; p < .001) as well as between atopic disorders and future poor mental health (r = .044, 95% confidence interval, 0.021-0.067, p < .001). More notably, the subgroup meta-analysis on the healthy and atopic disorder populations showed psychosocial factors had both an etiological and prognostic effect on atopic disorders.
  
  
  CONCLUSIONS
  The current review revealed a robust relationship between psychosocial factors and atopic disorders. This supports the use of psychological in addition to conventional physical and pharmacological interventions, in the successful prevention and management of atopic disorders.
authors.affiliation: Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom. y.chida@ucl.ac.uk.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Chida
authors.forename: Mark
authors.initials: M
authors.lastname: Hamer
authors.forename: Andrew
authors.initials: A
authors.lastname: Steptoe
mesh_terms: D001249:Asthma / Q000523:psychology*; D015331:Cohort Studies; D006304:Health Status; D006801:Humans; D006967:Hypersensitivity / Q000523:psychology*; D011379:Prognosis; D013315:Stress, Psychological