title: Biophosphonate-related osteonecrosis of the jaws.
abstract: In 2003 and 2004, the first reports of patients who developed necrosis of the jawbones while taking biophosphonates appeared in literature; most patients were on this drug for treatment of cancer and some osteoporosis. Since then, more than 500 cases have been identified and the number of these cases continues to grow. This article reviews the action of bisphosphonates, the condition called bisphosphonate-associated osteonecrosis of the jaws, strategies to minimize occurrence, and treatment of this condition.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stony Brook School of Dental Medicine, Stony Brook, NY, USA. drruggiero@nycoms.com
authors.forename: Salvatore L
authors.initials: SL
authors.lastname: Ruggiero
authors.forename: Sook-Bin
authors.initials: SB
authors.lastname: Woo
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000494:pharmacology; D004164:Diphosphonates / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D010020:Osteonecrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D011859:Radiography; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates