title: Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?
abstract: BACKGROUND
  Compositae-sensitive patients are routinely warned against topical use of Compositae-containing cosmetics and herbal remedies. However, the risk of elicitation of dermatitis in presensitized persons is unknown.
  
  
  OBJECTIVE
  The main aim of this study was to assess the significance of direct plant allergen contact via Compositae-derived cosmetics and herbal remedies in Compositae-allergic patients with special reference to arnica (Arnica montana) and German chamomile (Chamomilla recutita).
  
  
  METHODS
  8 of 12 chamomile-sensitive patients tested positive to chamomile-containing preparations, including tea, creams, ointments, and oil. 5 of 6 arnica-sensitive persons tested positive to arnica-based products.
  
  
  RESULTS
  When the group was patch tested with cosmetic and/or herbal product ingredients, plant allergens elicited positive reactions most frequently, but fragrances, emulsifiers, and preservatives tested positive as well. Plant allergens were mainly derived from Compositae, but avocado oil, and Hamamelis virginiana tincture were unexpectedly detected as sensitizers too. Chemical analyses indicated that the Compositae allergens were both sesquiterpene lactones and other naturally occurring compounds.
  
  
  CONCLUSIONS
  In conclusion, Compositae-allergic persons should be warned against topical use of Compositae-containing products, not only because of the plant allergens, but also because of allergenic cream constituents that may cause reactions in the group of patients who have multiple contact allergies beside the Compositae allergy.
authors.affiliation: National Allergy Research Centre, Gentofte, Denmark. evy.paulsen@ouh.regionsyddanmark.dk
authors.forename: Evy
authors.initials: E
authors.lastname: Paulsen
authors.forename: Lars P
authors.initials: LP
authors.lastname: Chistensen
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000279:Administration, Cutaneous; D018650:Arnica / Q000009:adverse effects; D019659:Asteraceae / Q000009:adverse effects*; D020843:Chamomile / Q000009:adverse effects; D003358:Cosmetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D029501:Hamamelis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D027421:Persea / Q000009:adverse effects; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000009:adverse effects; D010938:Plant Oils / Q000009:adverse effects; D028321:Plant Preparations / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D011446:Prospective Studies
chemical_list: D003358:Cosmetics; D010936:Plant Extracts; D010938:Plant Oils; D028321:Plant Preparations