title: [Gene expression regulation at the translational level: contribution of marine organisms].
abstract: Gene expression regulation is crucial for organism survival. Each step has to be regulated, from the gene to the protein. mRNA can be stored in the cell without any direct translation. This process is used by the cell to control protein synthesis rapidly at the right place, at the right time. Protein synthesis costs a lot of energy for the cell, so that a precise control of this process is required. Translation initiation represents an important step to regulate gene expression. Many factors that can bind mRNA and recruit different partners are involved in the inhibition or stimulation of protein synthesis. Oceans contain an important diversity of organisms that are used as important models to analyse gene expression at the translational level. These are useful to study translational control in different physiological processes for instance cell cycle (meiosis during meiotic maturation of starfish oocytes, mitosis following fertilization of sea urchin eggs) or to understand nervous system mechanisms (aplysia). All these studies will help finding novel actors involved in translational control and will thus be useful to discover new targets for therapeutic treatments against human diseases.
authors.affiliation: Centre National de la Recherche Scientifique, UMR 7150 Mer et Santé, France. oulhen@sb-roscoff.fr
authors.forename: Nathalie
authors.initials: N
authors.lastname: Oulhen
authors.forename: Julia
authors.initials: J
authors.lastname: Morales
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cosson
authors.forename: Odile
authors.initials: O
authors.lastname: Mulner-Lorillon
authors.forename: Robert
authors.initials: R
authors.lastname: Bellé
authors.forename: Patrick
authors.initials: P
authors.lastname: Cormier
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000818:Animals; D005260:Female; D005306:Fertilization; D005786:Gene Expression Regulation; D006801:Humans; D009865:Oocytes / Q000502:physiology; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D012623:Seawater
chemical_list: D020121:5' Untranslated Regions; D012333:RNA, Messenger
vernacular_title: Régulation de l'expression des gènes au niveau de la traduction: intérêt des modèles marins.