Ventilation during cardiopulmonary bypass: impact on cytokine response and cardiopulmonary function.
BACKGROUND
A complex inflammatory response associated with the use of cardiopulmonary bypass may ultimately lead to organ dysfunction. We investigate the effect of continuing ventilation during cardiopulmonary bypass on inflammatory reactions and cardiopulmonary function.


METHODS
Fifty patients undergoing cardiopulmonary bypass were prospectively randomized to continuous ventilation and nonventilation groups. Plasma interleukin-8, interleukin-10, matrix metalloproteinase-9, tissue inhibitor metalloproteinase-1, and thromboxane B2 levels were measured preoperatively, at 1, 4, and 6 hours after aortic declamping. Levels of these mediators were also determined in bronchoalveolar lavage preoperatively and four hours after declamping. Seven parameters of cardiopulmonary function, including dynamic compliance and systemic vascular resistance, were recorded during the same time points.


RESULTS
Plasma interleukin-10 levels were higher at 6 hours and tissue inhibitor metalloproteinase-1 levels were higher at 1 hour after aortic declamping in the continuous ventilation compared with the nonventilation group (p = 0.04 and 0.002, respectively), while bronchoalveolar lavage levels of tissue inhibitor metalloproteinase-1 were also higher in the continuous ventilation group 4 hours after declamping (p = 0.02). Plasma interleukin-8 levels were higher at 4 hours after declamping in the nonventilation group (p = 0.04). Postoperative dynamic compliance was better preserved in continuous ventilation patients than nonventilation patients at 6 hours after declamping (p = 0.0008).


CONCLUSIONS
Continued ventilation during cardiopulmonary bypass results in lesser inflammatory and proteolytic responses, and may better preserve pulmonary function than cardiopulmonary bypass without ventilation.
D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods / Q000401:mortality; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006334:Heart Function Tests; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods; D015999:Multivariate Analysis; D010100:Oxygen / Q000627:therapeutic use; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012121:Respiration, Artificial / Q000379:methods*; D012129:Respiratory Function Tests; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
D016207:Cytokines; D018836:Inflammation Mediators; D010100:Oxygen