title: [Bioluminescent imaging to monitor tumor progression and metastasis in live animal].
abstract: Animal models allowing more sensitive and early detection of tumorigenesis and metastasis are instrumental in the fight for developing effective therapies against aggressive forms of cancer. In the present chapter, the advantages and limitations of the bioluminescent imaging (BLI) approach are discussed. Although BLI provides rapid, highly sensitive, noninvasive and quantitative detection of small tumors and micrometastases, several issues like the low anatomic resolution or the attenuation of the luminescent signal with tissue depth must be considered when using this technology.
authors.affiliation: INSERM, U 553, Paris, F-75010, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Kauskot
authors.forename: Jan
authors.initials: J
authors.lastname: Manent
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chareyre
authors.forename: Márcia
authors.initials: M
authors.lastname: Cominetti
authors.forename: Martine
authors.initials: M
authors.lastname: Chopin
authors.forename: Marco
authors.initials: M
authors.lastname: Giovannini
authors.forename: Chantal
authors.initials: C
authors.lastname: Legrand
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bonnefoy
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D012680:Sensitivity and Specificity
vernacular_title: L'imagerie par bioluminescence pour visualiser la progression tumorale et la métastase chez le petit animal.