title: Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
abstract: The HMGA1 proteins have a critical role in the process of carcinogenesis. They are overexpressed in most human malignant neoplasias, and the inhibition of their expression has been shown to prevent cell transformation and results in malignant cell death. To determine whether HMGA1 proteins are also required for in vivo carcinogenesis, we compared the tumour susceptibility of mice wild-type or knockout for the Hmga1-null allele using a two-stage chemical skin carcinogenesis protocol. Hmga1-/- mice exhibited a decreased number and a delayed onset of skin papillomas in comparison with wild-type mice. Moreover, the progression of skin papillomas to carcinomas was observed in only 5% of Hmga1-/- compared to 18% of wild-type mice. These results suggest a lower susceptibility of Hmga1-/- mice to skin carcinogenesis induced by chemical agents.
authors.affiliation: Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, via Pansini, 5, 80131, Naples, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Visone
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Iuliano
authors.forename: Dario
authors.initials: D
authors.lastname: Palmieri
authors.forename: Ilter Nurettin
authors.initials: IN
authors.lastname: Server
authors.forename: Gennaro
authors.initials: G
authors.lastname: Chiappetta
authors.forename: Ivana
authors.initials: I
authors.lastname: De Martino
authors.forename: Monica
authors.initials: M
authors.lastname: Fedele
authors.forename: Stefan
authors.initials: S
authors.lastname: Costinean
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Oberyszyn
authors.forename: Donna F
authors.initials: DF
authors.lastname: Kusewitt
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D024003:HMGA Proteins / Q000235:genetics*; D015603:Keratinocytes / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010212:Papilloma / Q000139:chemically induced* / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000235:genetics; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000099193:rab11 GTP-Binding Proteins
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene; D002273:Carcinogens; D024003:HMGA Proteins; D016760:Proto-Oncogene Proteins c-fos; D013755:Tetradecanoylphorbol Acetate; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins