An efficient approach for monofluorination via aqueous fluorolactonization reaction of 2,3-allenoic acids with selectfluor.
We have developed a convenient method for the efficient monofluorination via the electrophilic fluorocyclization reaction of 2,3-allenoic acids with Selectfluor in MeCN in the presence of 10 equiv of H2O or even in pure water to afford beta-fluorobutenolides in moderate to high yields.
D000466:Alkadienes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D003500:Cyclization; D003979:Diazonium Compounds / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006860:Hydrogen Bonding; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D000466:Alkadienes; D002264:Carboxylic Acids; D003979:Diazonium Compounds; D007783:Lactones; D014867:Water; D005461:Fluorine; C408750:selectfluor