[Parameters of 24-hour blood pressure monitoring, and cardiovascular remodeling in patients with primary arterial hypertension].
The aim of the investigation was to study correlations between 24-hour blood pressure (BP) values and structural and functional remodeling of the cardiovascular system in patients with primary arterial hypertension (AH), in men and women separately. The subjects of the study were 158 patients with primary AH aged 39 to 68 years, including 84 males and 74 females. Twenty-four hour BP monitoring, two-dimensional Doppler echo CG, and duplex scanning of the carotids were performed. Linear correlation was used for statistical analysis. The data evidence a correlation between average 24-hour BP (ABP), one the one hand, and ABP time index, interventricular septum thickness (IVST), posterior left ventricular wall thickness (PLVT), and carotid intima-media complex thickness (CIMTC), on the other, in women. There was a reverse correlation between pulse BP and ejection fraction (EF), and a direct one with parameters of heart and vascular remodeling, such as IVST, PLVT, LV myocardial mass (MM), LVMM index, and IMTC in women. In men, changes in such 24-hour BP parameters, as BP variability and the degree of nocturnal BP decrease, leads to earlier myocardial remodeling with a decrease in contractility vs. women.
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013318:Stroke Volume; D020257:Ventricular Remodeling