title: Maternal cardiovascular function in pregnancies complicated by intrauterine growth restriction.
abstract: OBJECTIVE
  To investigate maternal cardiovascular function in pregnancies complicated by intrauterine growth restriction (IUGR).
  
  
  METHODS
  Maternal echocardiography and ambulatory blood pressure monitoring were performed in pregnancies complicated by IUGR (n = 12) and controls (n = 12), all of whom were normotensive at enrollment.
  
  
  RESULTS
  Compared to controls, maternal blood pressure (P = 0.016) and total vascular resistance (P = 0.008) were higher in IUGR pregnancies. Heart rate was lower (P = 0.003), as was systolic function expressed by midwall fractional shortening (P = 0.04). No significant differences between the two groups were observed for left atrial or left ventricular dimensions, nor for left ventricular geometry. Assessment of diastolic function by means of transmitral Doppler flow measurements revealed a significantly longer isovolumetric relaxation time in pregnancies with IUGR (P = 0.006).
  
  
  CONCLUSIONS
  In normotensive pregnancies complicated by IUGR, as compared to controls, there is decreased diastolic and systolic maternal cardiac function, and a higher blood pressure.
authors.affiliation: Maternal-Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University of Brescia, Brescia, Italy. federico.prefumo@libero.it
authors.forename: F
authors.initials: F
authors.lastname: Prefumo
authors.forename: M L
authors.initials: ML
authors.lastname: Muiesan
authors.forename: R
authors.initials: R
authors.lastname: Perini
authors.forename: A
authors.initials: A
authors.lastname: Paini
authors.forename: B
authors.initials: B
authors.lastname: Bonzi
authors.forename: A
authors.initials: A
authors.lastname: Lojacono
authors.forename: E
authors.initials: E
authors.lastname: Agabiti-Rosei
authors.forename: T
authors.initials: T
authors.lastname: Frusca
mesh_terms: D000328:Adult; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology*; D008429:Maternal Welfare; D011247:Pregnancy; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal / Q000379:methods; D014655:Vascular Resistance / Q000502:physiology