title: Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography.
abstract: We describe a novel instrument capable of acquiring, simultaneously, adaptive optics enhanced scanning laser ophthalmoscopy and optical coherence tomography (OCT) images of the human cone mosaic in vivo. The OCT system is based on transversal scanning of the sample with a line scan rate of 14 kHz, approximately 20 times faster than a previously reported instrument. We demonstrate the capability of this instrument with the measurement of the human cone spacing in perifoveal retina.
authors.affiliation: Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria. michael.pircher@meduniwien.ac.at
authors.forename: M
authors.initials: M
authors.lastname: Pircher
authors.forename: R J
authors.initials: RJ
authors.lastname: Zawadzki
authors.forename: J W
authors.initials: JW
authors.lastname: Evans
authors.forename: J S
authors.initials: JS
authors.lastname: Werner
authors.forename: C K
authors.initials: CK
authors.lastname: Hitzenberger
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D018613:Microscopy, Confocal / Q000295:instrumentation*; D019721:Ophthalmoscopes; D055095:Optics and Photonics / Q000295:instrumentation; D017949:Retinal Cone Photoreceptor Cells / Q000166:cytology*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*