[Metabolic and hemodynamic effects of combined treatment with metformine and rosiglitasone (avandium) in patients with diabetes mellitus type 2 and high cardiovascular risk].
OBJECTIVE
To study efficiacy of 24-week combined therapy with metformin and rosiglitasone in correction of metabolic parameters, blood pressure and total cardiovascular risk in patients with diabetes mellitus type 2.


METHODS
Blood pressure, body mass, glycemia and blood lipids, hyperinsulinemia, fat mass were studied in 30 patients with diabetes mellitus type 2 and hypertension on metformine treatment in a dose 1500 mg/day. When they entered the trial, metformine treatment was combined with rosiglitasone in a dose 4 mg/day. The combined treatment continued for 24 weeks.


RESULTS
The above combination significantly improved carbohydrate and lipid metabolism. The levels of fasting and postprandial glycemia, glycosylated hemoglobin, insulin resistance index significantly reduced. Both total and visceral fat tissue mass diminished. Improvement was seen in 24-h blood pressure monitoring data and intracardiac hemodynamics. Total cardiovascular risk decreased by three scales. Side effects were not registered.


CONCLUSIONS
Combined use of metformine and rosiglitasone in patients with diabetes type 2 is pathogenetically sound, highly effective and safe.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D012307:Risk Factors; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D008687:Metformin