[Effects of short-term immunosuppression on the engraftment of skin transplants at syndrome of the diabetic foot].
Effects of a single administration of small doses of 5-fluorouracil on results of skin plasty for syndrome of the diabetic foot were studied in 61 patients who had undergone local operations for pyo-necrotic diseases of the foot against the background of diabetes mellitus. The completion phase of their treatment was free dermal plasty with a split skin graft. Administration of 5-fluorouracil during the plasty operation was found to be accompanied by less marked inflammatory reaction in the transplant bed and in the graft. The frequency and square surface of lysis in the transplanted dermal skin graft were considerably lowered.
D001706:Biopsy; D001804:Blood Transfusion, Autologous; D017719:Diabetic Foot / Q000601:surgery*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation / Q000379:methods*; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D005472:Fluorouracil