title: Two-column simulated moving-bed process for binary separation.
abstract: A two-column simulated moving-bed system has been developed for binary separation. The system combines a flexible node design, robust pump configuration, and cyclic flow-rate modulation to exploit the benefits of simulated counter-current operation. The feasibility of the proposed two-column system is demonstrated on the linear separation of two nucleosides by reversed phase. Emphasis is given to the potentialities of the process compared to single-column batch chromatography with recycling for the same amount of stationary phase. The performance of the proposed two-column process is verified with laboratory-scale experiments and detailed simulations for different difficulties in separation and desorbent-to-feed ratios.
authors.affiliation: Requimte/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
authors.forename: Rui C R
authors.initials: RC
authors.lastname: Rodrigues
authors.forename: Tiago J S B
authors.initials: TJ
authors.lastname: Canhoto
authors.forename: João M M
authors.initials: JM
authors.lastname: Araújo
authors.forename: José P B
authors.initials: JP
authors.lastname: Mota
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation*