title: Design optimization of a novel pMDI actuator for systemic drug delivery.
abstract: Pressurized metered dose inhalers (pMDIs) are the most widely prescribed and economical respiratory drug delivery systems. Conventional pMDI actuators-those based on "two-orifice-and-sump" designs-produce an aerosol with a reasonable respirable fraction, but with high aerosol velocity. The latter is responsible for high oropharyngeal deposition, and consequently low drug delivery efficiency. Kos' pMDI technology is based on a proprietary vortex nozzle actuator (VNA), an innovative actuator configuration that seeks to reduce aerosol plume velocity, thereby promoting deep lung deposition. Using VNA development as a case study, this paper presents a systematic design optimization process to improve the actuator performance through use of advanced optical characterization tools. The optimization effort mainly relied on laser-based optical diagnostics to provide an improved understanding of the fundamentals of aerosol formation and interplay of various geometrical factors. The performance of the optimized VNA design thus evolved was characterized using phase Doppler anemometry and cascade impaction. The aerosol velocities for both standard and optimized VNA designs were found to be comparable, with both notably less than conventional actuators. The optimized VNA design also significantly reduces drug deposition in the actuator as well as USP throat adapter, which in turn, leads to a significantly higher fine particle fraction than the standard design (78 +/- 3% vs. 63 +/- 2% on an ex valve basis). This improved drug delivery efficiency makes VNA technology a practical proposition as a systemic drug delivery platform. Thus, this paper demonstrates how advanced optical diagnostic and characterization tools can be used in the development of high efficiency aerosol drug delivery devices.
authors.affiliation: Kos Pharmaceuticals, Inc., Morrisville, North Carolina 27560, USA. pkakade@mappharma.com
authors.forename: Prashant P
authors.initials: PP
authors.lastname: Kakade
authors.forename: Henk K
authors.initials: HK
authors.lastname: Versteeg
authors.forename: Graham K
authors.initials: GK
authors.lastname: Hargrave
authors.forename: Perry
authors.initials: P
authors.lastname: Genova
authors.forename: Robert C
authors.initials: RC
authors.lastname: Williams Iii
authors.forename: Daniel
authors.initials: D
authors.lastname: Deaton
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004867:Equipment Design; D006801:Humans; D036501:Metered Dose Inhalers
chemical_list: D000336:Aerosols