title: Prevalence of high-grade prostatic intraepithelial neoplasia in prostate gland of Korean men: comparisons between radical prostatectomy and cystoprostatectomy.
abstract: OBJECTIVE
  To evaluate the prevalence of high-grade prostatic intraepithelial neoplasia (HGPIN) and its association with prostate cancer in Korean men.
  
  
  METHODS
  A total of 160 patients who underwent radical prostatectomy for clinical prostate cancer were included as study subjects and 29 patients who underwent radical cystoprostatectomy for muscle-invasive bladder cancer were included as controls. Each intact prostate gland was serially sectioned at 3-mm intervals perpendicular to the posterior surface. The presence and prevalence of prostate cancer and HGPIN were assessed and their association evaluated.
  
  
  RESULTS
  High-grade prostatic intraepithelial neoplasia was present in 81 (70.4%) of 115 patients who underwent radical prostatectomy and in 8 (27.6%) of 29 patients who underwent cystoprostatectomy. This difference was statistically significant (P <0.001). Among the patients who underwent cystoprostatectomy, HGPIN was present in 5 (33.3%) of 15 patients with prostate cancer and in 3 (21.4%) of 14 patients with no evidence of prostate cancer. The presence of HGPIN had no correlation with prostate-specific antigen level, disease stage, tumor volume, grade, lymphovascular invasion, or surgical margin status.
  
  
  CONCLUSIONS
  The prevalence of HGPIN in Korean men with clinical prostate cancer was as great as that of Western men. Previous studies, and our results, had demonstrated a lower prevalence of HGPIN in Asian men who underwent cystoprostatectomy. The different prevalence of HGPIN found in incidental prostate cancer, between Asian and Western men, suggests that factors could be preventing the progression of prostate cancer or different characteristics of the prostate cancer in Asian populations.
authors.affiliation: Urologic Oncology Clinic, Division of Specific Organs Cancer, National Cancer Center, Goyang, South Korea.
authors.forename: Kyung Seok
authors.initials: KS
authors.lastname: Han
authors.forename: In Gab
authors.initials: IG
authors.lastname: Jeong
authors.forename: Jea Young
authors.initials: JY
authors.lastname: Joung
authors.forename: Seung Ok
authors.initials: SO
authors.lastname: Yang
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Chung
authors.forename: Ho Kyung
authors.initials: HK
authors.lastname: Seo
authors.forename: Weon Seo
authors.initials: WS
authors.lastname: Park
authors.forename: Kang Hyun
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000368:Aged; D015653:Cystectomy; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*