title: Response to hepatitis B vaccination in patients with celiac disease.
abstract: Abnormal immune response to gliadin, genetic, and environmental factors play a role in the pathogenesis of celiac disease (CD). Non-responsiveness to hepatitis B virus (HBV) vaccination is related to genetic features. Certain human leukocyte antigen (HLA) genotypes are more prevalent among non-responders to HBV vaccination. There is also a strong relationship between CD and these HLA genotypes. This study investigates the relationship between CD and non-responsiveness to HBV vaccination, with an emphasis on genotypic co-incidence. No statistically significant difference was noted between the ages and gender of CD patients and control subjects. Baseline serum IgA, IgM, and IgG levels of all CD patients were normal. Responsiveness to HBV vaccination was observed in 17 (68%) CD patients and all (100%) control subjects (P = 0.006). In conclusion, CD should also be sought in unresponders to HBV vaccine who are not immunosuppressed.
authors.affiliation: Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey. emelahishali@yahoo.com
authors.forename: Emel
authors.initials: E
authors.lastname: Ahishali
authors.forename: Gungor
authors.initials: G
authors.lastname: Boztas
authors.forename: Filiz
authors.initials: F
authors.lastname: Akyuz
authors.forename: Duygu
authors.initials: D
authors.lastname: Ibrisim
authors.forename: Sule
authors.initials: S
authors.lastname: Poturoglu
authors.forename: Binnur
authors.initials: B
authors.lastname: Pinarbasi
authors.forename: Sadakat
authors.initials: S
authors.lastname: Ozdil
authors.forename: Zeynel
authors.initials: Z
authors.lastname: Mungan
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines