title: [Updated strategies in Small Cell Lung Cancer post ASCO 2007].
abstract: Small Cell Lung Cancer (SCLC) is associated with intensive nicotine consumption and characterized by a very aggressive growth rate. Furthermore, metastases often appear very early. At the annual meeting of the "American Society of Clinical Oncology" (ASCO) 2007, recent issues which will influence the daily clinical practice were presented. New chemotherapy combinations such as carboplatin/irinotecan or pemetrexed as well as targeted therapies e.g. bevacizumab in combination with chemotherapy could extend our therapeutic options. A genetic polymorphism, which influences the pharmacokinetic of irinotecan, turned out to be one reason for the different outcome of an irinotecan/cisplatin therapy in a Japanese and Northern American population. In the field of radiotherapy, a phase III study showed for the first time a significant benefit in overall survival by prophylactic cranial radiation in the setting of extensive disease.
authors.affiliation: Abteilung für Innere Medizin, Landeskrankenhaus Hochzirl, Hochzirl, Osterreich.
authors.forename: Stefan
authors.initials: S
authors.lastname: Hoschek
authors.forename: Ursula
authors.initials: U
authors.lastname: Hoschek-Risslegger
authors.forename: Michael
authors.initials: M
authors.lastname: Fiegl
authors.forename: August
authors.initials: A
authors.lastname: Zabernigg
authors.forename: Georg
authors.initials: G
authors.lastname: Pall
authors.forename: Thomas
authors.initials: T
authors.lastname: Auberger
authors.forename: Eberhard
authors.initials: E
authors.lastname: Gunsilius
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmid
authors.forename: Herbert
authors.initials: H
authors.lastname: Jamnig
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hilbe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use* / Q000633:toxicity; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy; D017326:Clinical Trials, Phase III as Topic; D016371:Cranial Irradiation; D016503:Drug Delivery Systems; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D010166:Palliative Care; D011110:Polymorphism, Genetic / Q000235:genetics; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D019233:Retreatment
vernacular_title: Das kleinzellige Bronchialkarzinom - neue Entwicklungen nach ASCO 2007.