Mineral trioxide aggregate but not light-cure mineral trioxide aggregate stimulated mineralization.
The purpose of this study was to evaluate the subcutaneous response of rat connective tissue to light-cure MTA and Angelus MTA. These materials were placed in polyethylene and dentin tubes and implanted into dorsal connective tissue of Wistar rats for 30 and 60 days. The specimens were prepared to be stained with hematoxylin-eosin, Von Kossa, and without stain for polarized light and evaluated in an optic microscope. The Angelus MTA showed a mild inflammatory response at 30 days and none at 60 days, characterized by organized connective tissue, presence of some chronic inflammatory cells, and induction of mineralized tissue formation. Light-cure MTA presented a moderate chronic inflammatory response at 30 days that decreased at 60 days but was more intense than with Angelus MTA and without dystrophic calcifications. It was possible to conclude that light-cure MTA was similar to MTA at 60 days, but it did not stimulate mineralization.
D017607:Aluminum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D017610:Calcium Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D003238:Connective Tissue / Q000187:drug effects* / Q000502:physiology; D004338:Drug Combinations; D008027:Light; D008297:Male; D009999:Ossification, Heterotopic / Q000139:chemically induced; D010087:Oxides / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000627:therapeutic use*; D017640:Silicates / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate