title: Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes.
abstract: Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection.
authors.affiliation: Department of Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Savage
authors.forename: Keith
authors.initials: K
authors.lastname: Vosseller
authors.forename: Chulho
authors.initials: C
authors.lastname: Kang
authors.forename: Kevin
authors.initials: K
authors.lastname: Larimore
authors.forename: Elyn
authors.initials: E
authors.lastname: Riedel
authors.forename: Kathleen
authors.initials: K
authors.lastname: Wojnoonski
authors.forename: Achim A
authors.initials: AA
authors.lastname: Jungbluth
authors.forename: James P
authors.initials: JP
authors.lastname: Allison
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology*; D019264:Adoptive Transfer; D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006657:Histones / Q000276:immunology*; D006825:Hybridomas; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000276:immunology; D011471:Prostatic Neoplasms / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D001324:Autoantigens; D018984:Epitopes, T-Lymphocyte; D006657:Histones; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta