Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata.
Oral administration of BOS 2000 (1-10 mg/kg) elicited a dose related increase in the delayed hypersensitivity reaction (early 24 h and delayed 48 h) in mice. It also stimulated the IgM and IgG titre expressed in the form of plaques (PFC) and complement fixing antibody titre. The concentration of cytokines (IL-4, IFN-gamma and TNF-alpha) in serum with respect to T cell interactions, i.e. (CD4/CD8) and the proliferation of lymphocytes were significantly increased at 10 mg/kg compared with the control. The results in these studies demonstrated the immunostimulatory effect of BOS 2000 in a dose-dependent manner with respect to the macrophage activation possibly expressing the phagocytosis and nitrite production by the enhancement of TNF-alpha and IFN-gamma production as a mode of action.
Khajuria
Anamika
A
Division of Pharmacology, Indian Institute of Integrative Medicine, (CSIR, Jammu) 180001, India. anamikakhajuria@yahoo.com
Gupta
Amit
A
Suden
Pankaj
P
Singh
Surjeet
S
Malik
Fayaz
F
Singh
Jaswant
J
Gupta
B D
BD
Suri
K A
KA
Srinivas
V K
VK
Ella
Krishna
K
Qazi
G N
GN
D000818:Animals; D000906:Antibodies / Q000097:blood; D000917:Antibody Formation / Q000187:drug effects*; D029743:Boswellia / Q000737:chemistry*; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002176:Candida albicans; D016207:Cytokines / Q000097:blood; D006968:Hypersensitivity, Delayed; D007155:Immunologic Factors / Q000494:pharmacology*; D007978:Levamisole / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000032:analysis; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects
D000906:Antibodies; D016207:Cytokines; D007155:Immunologic Factors; D010936:Plant Extracts; D007978:Levamisole; D009569:Nitric Oxide