title: [Bilateral papillary necrosis during indinavir treatment].
abstract: BACKGROUND
  Papillary necrosis results from ischemia of the renal medulla and papillae, induced by a variety of mechanisms. Papillary necrosis is a rare adverse effect of continuous protease-inhibitor therapy with indinavir.
  
  
  METHODS
  We describe the case of a patient who developed bilateral papillary necrosis. It was reversible after treatment interruption and increased hydration.
  
  
  CONCLUSIONS
  This case shows the need to monitor kidney markers in patients under continuous treatment with indinavir.
authors.affiliation: Service de médecine interne A, Centre Hospitalier de Libreville, B.P. 2228, Libreville, Gabon. ibabajose@yahoo.fr
authors.forename: Josaphat
authors.initials: J
authors.lastname: Iba-Ba
authors.forename: Jean Cyr
authors.initials: JC
authors.lastname: Yombi
authors.forename: Etienne
authors.initials: E
authors.lastname: Danse
authors.forename: Benoît
authors.initials: B
authors.lastname: Van Beers
authors.forename: Bernard
authors.initials: B
authors.lastname: Vandercam
mesh_terms: D000328:Adult; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D008297:Male
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir