title: Anemia in beta-thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression.
abstract: Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression. We characterized hepatic hepcidin expression in 10 thalassemia major and 13 thalassemia intermedia patients. Hepcidin mRNA levels were decreased in the thalassemia intermedia group which presented both lower hemoglobin and higher plasma soluble transferrin receptor levels. There was no relationship between hepcidin mRNA levels and those of genes controlling iron metabolism, including HFE, hemojuvelin, transferrin receptor-2 and ferroportin. These results underline the role of erythropoietic activity on hepcidin decrease in thalassemic patients and suggest that mRNA modulations of other studied genes do not have a significant impact.
authors.affiliation: Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Camberlein
authors.forename: Giuliana
authors.initials: G
authors.lastname: Zanninelli
authors.forename: Lénaïck
authors.initials: L
authors.lastname: Détivaud
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Lizzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Sorrentino
authors.forename: Stefania
authors.initials: S
authors.lastname: Vacquer
authors.forename: Marie-Bérengère
authors.initials: MB
authors.lastname: Troadec
authors.forename: Emanuele
authors.initials: E
authors.lastname: Angelucci
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Abgueguen
authors.forename: Olivier
authors.initials: O
authors.lastname: Loréal
authors.forename: Paolo
authors.initials: P
authors.lastname: Cianciulli
authors.forename: Maria Eliana
authors.initials: ME
authors.lastname: Lai
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000150:complications*; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis*; D027682:Cation Transport Proteins / Q000096:biosynthesis; D005260:Female; D058851:GPI-Linked Proteins; D005786:Gene Expression Regulation; D000071020:Hemochromatosis Protein; D064451:Hepcidins; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis; D008875:Middle Aged; D011990:Receptors, Transferrin / Q000096:biosynthesis; D017086:beta-Thalassemia / Q000150:complications*; D000098742:Ferroportin
chemical_list: D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D058851:GPI-Linked Proteins; C578702:HAMP protein, human; C103673:HFE protein, human; C481006:HJV protein, human; D000071020:Hemochromatosis Protein; D064451:Hepcidins; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D011990:Receptors, Transferrin; C503640:TFR2 protein, human; D000098742:Ferroportin; D007501:Iron