[Antimicrobial susceptibility of 80 Moraxella catarrhalis strains isolated in the children's hospital of Tunis].
Eighty non-repetitive strains of Moraxella catarrhalis, isolated in Tunis Children's Hospital during five years from 1998 to 2002, were tested for their antimicrobial susceptibility, 95% of these strains were isolated from lung samples: 57.5% from trachea products, 35% from sputum and 2.5% from bronchial washings. The majority of strains (72%) were obtained from children under two years old. Antimicrobial susceptibility study showed that 95% of stains were beta-lactamase-producing, therefore they were penicillin G and amoxicillin resistant with high MICs. MIC(90) of penicillin G and amoxicillin of beta-lactamase-producing strains were respectively greater than 32 and 6 mg/l, these MIC decrease with addition of clavulanic acid. In fact, all strains studied were susceptible to the association amoxicillin-clavulanic acid as well as to cefotaxime. Concerning the other antimicrobial groups percentages of resistant strains found were as follows: erythromycin 3.75%, trimethoprim-sulfamethoxazol 12.5% and tetracycline 1.25%. Finally, all strains were susceptible to chloramphenicol, rifampicin and ciprofloxacin.
Khemiri
H
H
Laboratoire de microbiologie, hôpital d'Enfants de Tunis, Bab-Saadoun, 1006 Tunis, Tunisia. hanenkhemiri@yahoo.fr
Smaoui
H
H
Kechrid
A
A
D000658:Amoxicillin / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D019818:Clavulanic Acid / Q000494:pharmacology / Q000627:therapeutic use; D006776:Hospitals, Pediatric; D006801:Humans; D008168:Lung / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000302:isolation & purification; D045828:Moraxellaceae Infections / Q000453:epidemiology*; D014132:Trachea / Q000382:microbiology; D014416:Tunisia
D019818:Clavulanic Acid; D000658:Amoxicillin