Lipophilic peptides for gene delivery.
DNA transfections are widely performed in research laboratories and in vivo gene delivery holds the promise for curing many diseases. The synthetic carriers or vectors for DNA are typically cationic lipids. However, in biology, the recognition of nucleic acids by proteins involves both electrostatic and stacking contributions. As such we have prepared a series of new lipophilic peptide vectors that possess lysine and tryptophan amino acids for evaluation. These lipophilic peptides show minimal cytotoxicity and enhanced in vitro gene transfection activity.
Prata
Carla A H
CA
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Zhang
Xiao-Xiang
XX
Luo
Dan
D
McIntosh
Thomas J
TJ
Barthelemy
Philippe
P
Grinstaff
Mark W
MW
D018014:Gene Transfer Techniques; D010455:Peptides / Q000737:chemistry*
D010455:Peptides