BRCA1--sowing the seeds crooked in the furrow.
Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.
Foulkes
William D
WD
William D. Foulkes is in the Program in Cancer Genetics, Department of Oncology, McGill University, Montreal, Quebec H2W 1S6, Canada. william.foulkes@mcgill.ca
D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D051059:PTEN Phosphohydrolase / Q000235:genetics*
D019313:BRCA1 Protein; D051059:PTEN Phosphohydrolase