Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in patients with asthma. New evidence, however, suggests that ASM may also orchestrate and perpetuate airway inflammation by promoting the recruitment, activation, and trafficking of inflammatory cells in the airways. This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma.
Tliba
Omar
O
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104-3403, USA. omartlib@mail.med.upenn.edu
Amrani
Yassine
Y
Panettieri
Reynold A
RA
D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000502:physiology*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*
D015815:Cell Adhesion Molecules; D018925:Chemokines; D005938:Glucocorticoids; D007155:Immunologic Factors