title: MicroRNA signature predicts survival and relapse in lung cancer.
abstract: We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan 100, Republic of China.
authors.forename: Sung-Liang
authors.initials: SL
authors.lastname: Yu
authors.forename: Hsuan-Yu
authors.initials: HY
authors.lastname: Chen
authors.forename: Gee-Chen
authors.initials: GC
authors.lastname: Chang
authors.forename: Chih-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Huei-Wen
authors.initials: HW
authors.lastname: Chen
authors.forename: Sher
authors.initials: S
authors.lastname: Singh
authors.forename: Chiou-Ling
authors.initials: CL
authors.lastname: Cheng
authors.forename: Chong-Jen
authors.initials: CJ
authors.lastname: Yu
authors.forename: Yung-Chie
authors.initials: YC
authors.lastname: Lee
authors.forename: Han-Shiang
authors.initials: HS
authors.lastname: Chen
authors.forename: Te-Jen
authors.initials: TJ
authors.lastname: Su
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Chiang
authors.forename: Han-Ni
authors.initials: HN
authors.lastname: Li
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Hong
authors.forename: Hsin-Yuan
authors.initials: HY
authors.lastname: Su
authors.forename: Chun-Chieh
authors.initials: CC
authors.lastname: Chen
authors.forename: Wan-Jiun
authors.initials: WJ
authors.lastname: Chen
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Liu
authors.forename: Wing-Kai
authors.initials: WK
authors.lastname: Chan
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Ker-Chau
authors.initials: KC
authors.lastname: Li
authors.forename: Jeremy J W
authors.initials: JJ
authors.lastname: Chen
authors.forename: Pan-Chyr
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification / Q000235:genetics* / Q000473:pathology; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D035683:MicroRNAs