title: A new leishmanicidal saponin from Brunfelsia grandiflora.
abstract: A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-->3)-{beta-D-glucopyranosyl(1-->2)}-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.
authors.affiliation: Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Ibaraki, Japan. fuchino@nibio.go.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
authors.forename: Kanami
authors.initials: K
authors.lastname: Mori
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawahara
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018320:Leishmania major / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D015394:Molecular Structure; D010568:Peru; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019657:Solanaceae / Q000737:chemistry*
chemical_list: C525768:26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-3)-(beta-D-glucopyranosyl(1-2))beta-D-glucopyranosyl(1-4)beta-D-glucopyranoside; D000981:Antiprotozoal Agents; D012503:Saponins