title: 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity.
abstract: A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.
authors.affiliation: Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Morinaka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Shinoda
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nishi
authors.forename: Nobuko
authors.initials: N
authors.lastname: Fukushima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Akira
authors.initials: A
authors.lastname: Ishibashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yuki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D048288:Imidazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D048288:Imidazolines