Noise in solid-state nanopores.
We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies (f approximately < 100 Hz) we observe 1/f-type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter alpha = (1.1 +/- 0.1) x 10(-4). In the high-frequency regime (f approximately > 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.
Smeets
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RM
Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
Keyser
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UF
Dekker
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Dekker
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D000465:Algorithms; D001692:Biological Transport; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007477:Ions; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010100:Oxygen / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D015203:Reproducibility of Results; D012492:Salts / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry; D012984:Software; D013696:Temperature
D007477:Ions; D012492:Salts; D012313:RNA; D012822:Silicon Dioxide; D004247:DNA; D010100:Oxygen