Silencing metabolic disorders by novel SIRT1 activators.
SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.
Sakamoto
Kei
K
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, UK. k.sakamoto@dundee.ac.uk
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008954:Models, Biological; D000077185:Resveratrol; D056564:Sirtuin 1; D037761:Sirtuins / Q000819:agonists* / Q000378:metabolism / Q000502:physiology; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D013267:Stilbenes; C447939:SIRT1 protein, human; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins; D000077185:Resveratrol