Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.
The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.
Gulsen
Salih
S
Department of Neurosurgery, Hacettepe University, Ankara, Turkey. gulsen.salih@gmail.com
Inci
Servet
S
Yuruk
Sinan
S
Yasar
Umit
U
Ozgen
Tuncalp
T
D000818:Animals; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D008297:Male; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000473:pathology; D020301:Vasospasm, Intracranial / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*
D004965:Estrogen Antagonists; D020849:Raloxifene Hydrochloride