title: Two new cycloartane saponins from the roots of Astragalus membranaceus.
abstract: Two new cycloartane-type triterpenoid saponins were isolated from the roots of Astragalus membranaceus (FISCH.) BGE. (Leguminosae) cultivated in Kangwon province, Korea. These saponins were named astramembranosides A and B and were established to be cycloastragenol 6,25-di-O-beta-D-glucopyranoside (astramembranoside A) and cyclocanthogenin 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-xylopyranoside (astramembranoside B) on the basis of chemical and spectral evidence. In addition, 12 known saponins were also isolated from the same materials. Although cycloastragenol 3-O-xyloside and agroastragalosides I and II have already been isolated from A. membranaceus adventitious roots, these three saponins together with brachyoside B and azukisaponin V methyl ester were isolated for the first time from this plant.
authors.affiliation: Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Min-Hye
authors.initials: MH
authors.lastname: Yean
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Lee
authors.forename: Hye Sil
authors.initials: HS
authors.lastname: Jung
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D027885:Astragalus propinquus / Q000737:chemistry*; D007723:Korea; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D012503:Saponins; D014315:Triterpenes; C525772:astramembranoside A; C525773:astramembranoside B; C085352:cycloartane