79-year-old post-menopausal woman with humerus fracture during teriparatide treatment.
The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus calcium and vitamin D supplementation. After two years, she presented new acute back pain, and spinal X-rays revealed new vertebral compression fractures at T8 and T11. In September 2004, she stopped alendronate therapy and began teriparatide 20 microg subcutaneously each day for 18 months, associated with a dose of 1200 mg/day of calcium and 880 IU/day of vitamin D. In July 2005, she fell and sustained a fracture of the left proximal humerus. She was treated with conservative therapy and continued teriparatide therapy. After 25 days of conservative management, left shoulder X-ray showed quick formation of fracture healing. In conclusion, although teriparatide is indicated for the treatment of severe osteoporosis and not to enhance fracture healing, there are many experimental data which indicate that it may be beneficial also in enhancing fracture healing.
Resmini
Giuseppina
G
Centro per lo Studio dell'Osteoporosi e delle Malattie Metaboliche dell'Osso, U.O. di Ortopedia e Traumatologia, A.O. Ospedale di Treviglio-Caravaggio, Bergamo, Italy. giuseppina_resmini@ospedale.treviglio.bg.it
Iolascon
Giovanni
G
D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D005598:Fractures, Spontaneous / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D006810:Humeral Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011859:Radiography; D019379:Teriparatide / Q000627:therapeutic use*; D013904:Thoracic Vertebrae / Q000187:drug effects / Q000473:pathology
D050071:Bone Density Conservation Agents; D019379:Teriparatide