title: Axon myelin transfer of a non-enveloped virus.
abstract: We showed previously that Theiler's virus, a neurotropic non-enveloped picornavirus of mouse, traffics from the axon of infected neurons into the surrounding myelin. When this traffic is interrupted, as in the shiverer mouse which bears a mutation in the myelin basic protein gene, the virus is unable to persist in the central nervous system. In the present work, we used the Wld(s) mutant mouse, a strain in which axonal degeneration is considerably slowed down, to show that axon to myelin traffic takes place in the absence of axon degeneration. Our results suggest the existence of a mechanism of transfer of axonal cytoplasm into the myelin which Theiler's virus might exploit to ensure its persistence.
authors.affiliation: Department of Virology, URA3015 Centre National de Recherche Scientifique (CNRS), Institut Pasteur, Paris, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Roussarie
authors.forename: Claude
authors.initials: C
authors.lastname: Ruffié
authors.forename: Julia M
authors.initials: JM
authors.lastname: Edgar
authors.forename: Ian
authors.initials: I
authors.lastname: Griffiths
authors.forename: Michel
authors.initials: M
authors.lastname: Brahic
mesh_terms: D000818:Animals; D001369:Axons; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains; D009186:Myelin Sheath / Q000502:physiology*; D009900:Optic Nerve / Q000821:virology; D012160:Retina / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017945:Theilovirus / Q000502:physiology*