High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
Kasprowicz
Victoria
V
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
Schulze Zur Wiesch
Julian
J
Kuntzen
Thomas
T
Nolan
Brian E
BE
Longworth
Steven
S
Berical
Andrew
A
Blum
Jenna
J
McMahon
Cory
C
Reyor
Laura L
LL
Elias
Nahel
N
Kwok
William W
WW
McGovern
Barbara G
BG
Freeman
Gordon
G
Chung
Raymond T
RT
Klenerman
Paul
P
Lewis-Ximenez
Lia
L
Walker
Bruce D
BD
Allen
Todd M
TM
Kim
Arthur Y
AY
Lauer
Georg M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D015415:Biomarkers; D018106:CD28 Antigens / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular; D008099:Liver / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D061026:Programmed Cell Death 1 Receptor
D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D018106:CD28 Antigens; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor