[Clinical observation on treatment of children's mild continuous asthma by Fangchuan Mixture combined with flixotide].
OBJECTIVE
To investigate the efficacy and mechanism of Fangchuan Mixture (FCM) in treating children with mild continuous asthma.


METHODS
One hundred and seventy-five patients in the three groups were treated with FCM (A), Flixotide (B), and the combination of FCM and Flixotide (C), respectively for 12 weeks. Their condition of asthma and TCM syndrome were observed, peak expiratory flow (PEF) and serum levels of immunoglobulin (Ig), interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) were determined.


RESULTS
All the indexes determined were improved significantly in the three groups after treatment (P <0.05). Paired comparison among groups showed that the improvements in non-asthma time, time required beta-receptor activator, expectoration, complexion, appetite, and increasing serum IFN-gamma after treatment were superior in Group C than in Group A and B (P <0.05); the improvements in hidrosis, faint pulse and decreasing serum IL-4 level in Group A and C were better than those in Group B (P <0.05), and the effect for alleviating symptoms of rhinitis such as nasal obstruction and nasal discharge in Group C was more significant than that in Group B (P <0.05).


CONCLUSIONS
FCM could attenuate the allergic inflammation of bronchi to improve its hypersensitive state in children with asthma, and shows a cooperative action with Flixotide.
Ren
Qin
Q
The First Affiliated Hospital of Tianjin TCM University, Tianjin. renqin1963@163.com
Du
Hong-zhe
HZ
D000293:Adolescent; D000730:Androstadienes / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008517:Phytotherapy; D016896:Treatment Outcome
D000730:Androstadienes; D001993:Bronchodilator Agents; D004365:Drugs, Chinese Herbal; C533489:fangchuan; D000068298:Fluticasone