title: Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists.
abstract: Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: David M
authors.initials: DM
authors.lastname: Pass
authors.forename: Julia K
authors.initials: JK
authors.lastname: Archbold
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D001315:Australia; D006801:Humans; D015394:Molecular Structure; D009475:Neurons, Afferent / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*
chemical_list: D010456:Peptides, Cyclic; D043562:Receptors, G-Protein-Coupled; C527502:polydiscamide B; C527503:polydiscamide C; C527504:polydiscamide D