Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil.
Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.
Kossuga
Miriam H
MH
Instituto de quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Brazil.
Nascimento
Andréa M
AM
Reimão
Juliana Q
JQ
Tempone
André G
AG
Taniwaki
Noemi Nosomi
NN
Veloso
Katyuscya
K
Ferreira
Antonio G
AG
Cavalcanti
Bruno C
BC
Pessoa
Claudia
C
Moraes
Manoel O
MO
Mayer
Alejandro M S
AM
Hajdu
Eduardo
E
Berlinck
Roberto G S
RG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects / Q000648:ultrastructure; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008386:Marine Biology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D020078:Neurogenic Inflammation / Q000188:drug therapy; D009569:Nitric Oxide / Q000096:biosynthesis; D047229:Plakortis / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D018942:Macrolides; C528781:plakortenone; D009569:Nitric Oxide