title: Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.
abstract: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR 677 TT in the meta-analysis (odds ratio (OR) = 1.52, 95% confidence interval (CI): 1.31, 1.77) and pooled analysis (OR = 1.49, 95% CI: 1.14, 1.95). No association resulted for MTHFR 1298 CC (meta-OR = 0.94, 95% CI: 0.65, 1.35; pooled OR = 0.90, 95% CI: 0.69, 1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR = 2.05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.
authors.affiliation: Institute of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy. sboccia@rm.unicatt.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Boccia
authors.forename: Rayjean
authors.initials: R
authors.lastname: Hung
authors.forename: Gualtiero
authors.initials: G
authors.lastname: Ricciardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Gianfagna
authors.forename: Matthias P A
authors.initials: MP
authors.lastname: Ebert
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Fang
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Gao
authors.forename: Tobias
authors.initials: T
authors.lastname: Götze
authors.forename: Francesco
authors.initials: F
authors.lastname: Graziano
authors.forename: Marina
authors.initials: M
authors.lastname: Lacasaña-Navarro
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.forename: Lizbeth
authors.initials: L
authors.lastname: López-Carrillo
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Rachael
authors.initials: R
authors.lastname: Stolzenberg-Solomon
authors.forename: Toshiro
authors.initials: T
authors.lastname: Takezaki
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Weng
authors.forename: Fang Fang
authors.initials: FF
authors.lastname: Zhang
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
mesh_terms: D001208:Asia / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005492:Folic Acid / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009656:North America / Q000453:epidemiology; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)