Fluxing the mitochondria to insulin resistance.
Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koves et al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.
Watt
Matthew J
MJ
St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. mwatt@svi.edu.au
Hevener
Andrea L
AL
D000818:Animals; D002952:Citric Acid Cycle; D005227:Fatty Acids / Q000378:metabolism; D007333:Insulin Resistance; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction
D005227:Fatty Acids