title: Paramphistomicidal efficacy of an experimental compound in sheep.
abstract: The aim of the present study was to determine the paramphistomicidal efficacy of methyl [5-chloro-6-(1-naphthyloxy)-1H-benzimidazol-2-yl]carbamate (alpha-carbamate) in experimentally infected sheep. Sixteen crossbred rams were infected each with 600 metacercariae of Calicophoron calicophorum. Forty five days after infection, they were divided into four groups of four animals each. Groups 1 to 3 received compound alpha-carbamate at a dose of 12, 18, and 24 mg/kg b/w, respectively; group 4 serving as the nontreated control. Ten days after treatment, all animals were killed to obtain the rumen and collect, measure, and quantify the trematodes present. Efficacy was assessed as the percentage of trematode reduction of the treated groups relative to the nontreated control. The obtained efficacy indicated a percentage reduction of 86.7%, 97.5%, and 100% for groups 1, 2, and 3, respectively. This experimental compound showed high efficacy against 45-day-old C. calicophorum in experimentally infected sheep.
authors.affiliation: Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, DF 04510 México, México.
authors.forename: P M
authors.initials: PM
authors.lastname: Reyes
authors.forename: V F
authors.initials: VF
authors.lastname: Ibarra
authors.forename: M Y
authors.initials: MY
authors.lastname: Vera
authors.forename: A G
authors.initials: AG
authors.lastname: Cantó
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: C A
authors.initials: CA
authors.lastname: Hernández
authors.forename: R
authors.initials: R
authors.lastname: Castillo
authors.forename: M A
authors.initials: MA
authors.lastname: Villa
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012417:Rumen / Q000469:parasitology; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D014200:Trematoda / Q000187:drug effects*; D014201:Trematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D009281:Naphthalenes; C031000:benzimidazole