The dual immunoregulatory roles of stress proteins.
Stress proteins (SPs) from the heat shock and glucose-regulated protein families are abundant intracellular molecules that have powerful extracellular roles as immune modulators. Mammalian immune cells encounter both identical (self) SPs and non-identical SPs derived from invading pathogens. Although such extracellular SPs can function as powerful immunological adjuvants, SPs, including Hsp60 and Hsp70, can also attenuate inflammatory disease via apparent effects on immunoregulatory T cell populations. It therefore seems that the immunostimulatory and immunosuppressive potential of extracellular SPs depends on the context in which they are encountered by the cellular immune-response network. Conclusions regarding the immunobiology of these powerful immunomodulatory molecules must therefore take into account their dichotomous properties and their physiological role and importance must be interpreted in the context of the complex in vivo microenvironments in which these proteins exist.
Pockley
Alan Graham
AG
School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. g.pockley@sheffield.ac.uk
Muthana
Munitta
M
Calderwood
Stuart K
SK
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D006360:Heat-Shock Proteins / Q000235:genetics / Q000276:immunology*; D007107:Immune System / Q000502:physiology*; D007166:Immunosuppressive Agents / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D018832:Molecular Chaperones / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents; D018832:Molecular Chaperones; D011956:Receptors, Cell Surface