Comparative histomorphometric and tomographic analysis of maxillary sinus floor augmentation in rabbits using autografts and xenografts.
Our goal was to evaluate bone neoformation promoted by a bovine xenograft composite (XC) compared with autogenous graft for maxillary sinus augmentation in a rabbit model. The left maxillary sinus of 18 male rabbits was filled with 200 mg of cortical and cancellous autogenous bone and the right sinus was filled with 200 mg of a composite comprised organic and inorganic bovine matrices, pool of bBMPs and collagen. Postoperative implant intervals of 2, 4, and 8 weeks were analyzed. Differences in the bone optical density among the groups and experimental periods were evaluated by computed tomography analysis. The tissue response was evaluated by histomorphometric analysis of the newly formed bone, connective tissue and/or granulation tissue, residual material, and bone marrow. The tomographic analyses showed a maximum optical density in the 4-week period for both groups. Histologically, an inflammatory infiltrate was observed at 2 weeks in the XC group but exclusively around the organic particles of the biomaterial. Regarding to the amount of newly formed bone, no statistical differences (p > 0.05) were observed among the two treatments throughout the implant intervals. However, by the end of the 8 weeks, the quantity of bone marrow was two times greater (p < 0.05) in the control group than in the XC group. In conclusion, the xenograft composite promotes formation of new bone in a similar fashion to autogenous bone and could therefore be considered a biomaterial with potential applications as a bone substitute in maxillary sinus floor augmentation.
Sicca
Cristina Miguel
CM
Department of Biological Sciences, Bauru Dental School, University of São Paulo, Brazil.
Corotti
Mauro Vinícius
MV
Sgarbosa
Sílvia Helena Pereira Vergili
SH
Cestari
Tania Mary
TM
Cavalcanti
Marcelo Gusmão Paraíso
MG
Ferreira
Paulo Martins
PM
Taga
Rumio
R
Granjeiro
José Mauro
JM
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D032701:Biomimetics; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D019485:Bone Morphogenetic Proteins / Q000737:chemistry; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen / Q000737:chemistry; D007249:Inflammation; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology*; D011817:Rabbits; D014054:Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D003094:Collagen