title: Incidence of diffuse lamellar keratitis after laser in situ keratomileusis associated with the IntraLase 15 kHz femtosecond laser and Moria M2 microkeratome.
abstract: OBJECTIVE
  To analyze the incidence of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK) performed with an IntraLase 15 kHz femtosecond laser (IntraLase, Corp.) or a Moria M2 mechanical microkeratome (Moria SA).
  
  
  METHODS
  Vissum Madrid, Madrid, Spain.
  
  
  METHODS
  This retrospective study compared the incidence of DLK in consecutive LASIK procedures performed with the IntraLase 15 kHz femtosecond laser (study group) or the Moria M2 microkeratome (control group). Two surgeons performed both types of surgeries (femtosecond laser and microkeratome) using the same excimer laser (Technolas 217, Bausch & Lomb). During the first week postoperatively, topical dexamethasone drops were applied 8 times daily in the femtosecond group and 4 times daily in the mechanical microkeratome group.
  
  
  RESULTS
  A total of 2000 consecutive eyes were analyzed (1000 eyes in each group). Diffuse lamellar keratitis stage 2 developed in 1 patient in each group; DLK stage 3 developed in 4 patients in the study group and in no patient in the control group (P = .03).
  
  
  CONCLUSIONS
  Despite more intense postoperative steroid treatment, DLK seemed to occur more frequently after LASIK performed with the IntraLase 15 kHz femtosecond laser than after LASIK performed with the Moria M2 microkeratome.
authors.affiliation: Vissum Madrid, E.U. Optica Universidad Complutense de Madrid, Madrid, Spain. raquelgil@cnoo.es
authors.forename: Raquel
authors.initials: R
authors.lastname: Gil-Cazorla
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Teus
authors.forename: Laura
authors.initials: L
authors.lastname: de Benito-Llopis
authors.forename: Irene
authors.initials: I
authors.lastname: Fuentes
mesh_terms: D000328:Adult; D003319:Corneal Stroma / Q000473:pathology*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007634:Keratitis / Q000188:drug therapy / Q000209:etiology*; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects* / Q000295:instrumentation; D008297:Male; D011182:Postoperative Care; D012189:Retrospective Studies
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone