Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study.
OBJECTIVE
To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals.


RESULTS
In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coronary heart disease (CHD) mortality by APOE genotype, both overall and in subgroups defined by body mass index (BMI). We found significant evidence for interaction between APOE and BMI in relation to total cholesterol (p=0.04) and HDL cholesterol (p<0.001). Overall, APOE*2 carriers showed a decreased risk of all-cause mortality. Analyses within BMI strata showed a beneficial effect of APOE*2 only in normal weight persons (adjusted hazard ratio (HR) 0.7[95% CI 0.5-0.9]). APOE*2 was not associated with a lower risk of all-cause mortality in overweight or obese persons. The effect of APOE*2 in normal weight individuals tended to be due to the risk of CHD mortality (adjusted HR 0.5 [95% CI 0.2-1.2]).


CONCLUSIONS
The APOE*2 allele confers a lower risk of all-cause mortality only to normal weight individuals.
Pardo Silva
M Carolina
MC
Department of Epidemiology & Biostatistics, Erasmus MC University Medical Center Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
Janssens
A Cecile J W
AC
Hofman
Albert
A
Witteman
Jacqueline C M
JC
van Duijn
Cornelia M
CM
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D001835:Body Weight; D003327:Coronary Disease / Q000401:mortality; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009426:Netherlands / Q000453:epidemiology; D012306:Risk; D017751:Safety Management
D001057:Apolipoproteins E