The successful use of ondansetron in a boy with both leukemia and Tourette syndrome.
This article reports an 8-year-old boy with both acute lymphoblastic leukemia and Gilles de la Tourette syndrome. Initially, for his leukemia, he was treated with chemotherapy, which resulted in severe nausea and vomiting for which he was given ondansetron. This not only relieved the target symptoms, but also those of his Gilles de la Tourette syndrome. Following a reduction of the ondansetron dosage, his Gilles de la Tourette syndrome symptoms reemerged.
Rizzo
Renata
R
Section of Child Neuropsychiatry, Department of Pediatrics University of Catania, Azienda Policlinico, Catania, Italy. rerizzo@unict.it
Marino
Santo
S
Gulisano
Mariangela
M
Robertson
Mary M
MM
D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001712:Biperiden / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002648:Child; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology; D017294:Ondansetron / Q000008:administration & dosage*; D010868:Pimozide / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D012008:Recurrence; D012702:Serotonin Antagonists / Q000008:administration & dosage*; D020323:Tics / Q000188:drug therapy / Q000503:physiopathology; D005879:Tourette Syndrome / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
D018726:Anti-Dyskinesia Agents; D000932:Antiemetics; D000970:Antineoplastic Agents; D012702:Serotonin Antagonists; D001712:Biperiden; D010868:Pimozide; D017294:Ondansetron