[Invasive zygomycosis: notably in diabetes mellitus and iron overload].
The incidence of invasive zygomycosis, a severe and often life-threatening infection, is increasing. The most common manifestations are pulmonary infection (following anti-cancer chemotherapy or haematopoietic stem-cell transplant) and invasive rhinocerebral infection (in patients with diabetes mellitus or iron overload). Iron metabolism plays an important role in the pathogenesis of infection in these high-risk populations. Rapid diagnosis, reversal of the underlying predisposition and timely surgical debridement are the underlying principles of therapy for this disease.
Kullberg
B J
BJ
Universitair Medisch Centrum St Radboud, Nijmeegs Universitair Centrum voor Infectieziekten, Nijmegen. b.kullberg@aig.umcn.nl
van 't Wout
J W
JW
D000935:Antifungal Agents / Q000627:therapeutic use; D003646:Debridement / Q000379:methods; D048909:Diabetes Complications / Q000276:immunology*; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007501:Iron / Q000378:metabolism*; D012307:Risk Factors; D033581:Stem Cell Transplantation / Q000009:adverse effects; D020096:Zygomycosis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy
D000935:Antifungal Agents; D007501:Iron