Clinical management of EGFRI dermatologic toxicities: the Japanese perspective.
Epidermal growth factor receptor inhibitors (EGFRIs) have demonstrated clinical activity in patients with non-small-cell lung cancer, pancreatic cancer, and colorectal cancer. EGFRIs are generally well tolerated, but reversible dermatologic toxicities are commonly associated with their use. Limited clinical evidence has characterized these adverse reactions as a class effect. For panitumumab (Vectibix), mild-to-moderate dermatologic toxicities are the most common associated adverse reactions. This report details the Japanese experience in the management of dermatologic toxicities associated with panitumumab use. Treatment selection for skin toxicity in Japan is also detailed, with a flowchart depicting strategies to treat various stages of dermatologic toxicities. Panitumumab was well tolerated in Japanese patients with advanced solid tumors, with a safety profile similar to that seen in non-Japanese patients.
Yamazaki
Naoya
N
Dermatology Division, National Cancer Center Hospital, Tokyo, Japan. nyamazak@ncc.go.jp
Muro
Kei
K
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000188:drug therapy*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007564:Japan; D009369:Neoplasms / Q000188:drug therapy; D000077544:Panitumumab; D013256:Steroids / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D013256:Steroids; D014815:Vitamins; D000077544:Panitumumab; D066246:ErbB Receptors