title: C-reactive protein and acute coronary syndrome: comparison of conservative and interventional management.
abstract: BACKGROUND
  Inflammation plays a key role in the initiation and progression of atherosclerosis, the most common cause of acute coronary syndrome. C-reactive protein (CRP) that enhances plaque inflammation is synthesized six hours after myocardial infarction.
  
  
  METHODS
  High sensitivity C-reactive protein was measured by Immunoturbiditory method in 50 healthy controls and 100 patients of acute coronary syndrome on conservative or interventional management.
  
  
  RESULTS
  Serum C-reactive protein levels [mg/L +/- SEM] at the time of admission were significantly raised in patients of acute coronary syndrome (11.90 +/- 2.30) as compared to controls (2.30 +/- 0.18) and further increased progressively during 24 hours of follow up period. C-reactive protein levels also increased significantly in patients who underwent interventional management (115.90 +/- 7.73) as compared to those who were on conservative management (22.28 +/- 5.54).
  
  
  CONCLUSIONS
  Serum C-reactive protein levels were found to be significantly raised in patients with acute coronary syndrome as compared to controls. In addition, patients undergoing interventional management had higher C-reactive protein levels, post intervention, as compared to those on conservative management.
authors.affiliation: Section of Physiology, Shifa College of Medicine, Islamabad. tahirahmadmunir1@hotmail.com
authors.forename: Tahir Ahmad
authors.initials: TA
authors.lastname: Munir
authors.forename: M Nasir
authors.initials: MN
authors.lastname: Afzal
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D000789:Angina, Unstable; D002097:C-Reactive Protein; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D011379:Prognosis; D013997:Time Factors; D019210:Troponin I
chemical_list: D019210:Troponin I; D002097:C-Reactive Protein; D052279:Creatine Kinase, MB Form