title: Use of the combined first-trimester screen result and low PAPP-A to predict risk of adverse fetal outcomes.
abstract: OBJECTIVE
  To investigate associations between combined first-trimester screen result, pregnancy associated plasma protein-A (PAPP-A) level and adverse fetal outcomes in women.
  
  
  METHODS
  Pregnancy outcomes for 10,273 women participating in a community based first-trimester screening (FTS) programme in Western Australia were ascertained by record linkage to birth and birth defect databases. A first-trimester risk cut-off of > or = 1 in 300 defined screen positive women.
  
  
  RESULTS
  Screen positive pregnancies were more likely to have Down syndrome and birth defects (chromosomal or nonchromosomal) than screen negative pregnancies. When birth defects were excluded, screen positive pregnancies were at increased risk of pregnancy loss, low birth weight and preterm birth. Pregnancies with low PAPP-A (< or =0.3 multiples of the median (MoM)) had higher risk of chromosomal abnormality, birth defect, preterm birth, low birth weight, or pregnancy loss, compared to those with PAPP-A > 0.3 MoM. In pregnancies without birth defects, low PAPP-A was a stronger predictor of preterm birth, low birth weight or pregnancy loss than a screen positive result.
  
  
  CONCLUSIONS
  Women with positive screen or low PAPP-A were at increased risk for some adverse fetal outcomes. The sensitivity of these parameters was insufficient to support primary screening, but increased surveillance during pregnancy may be appropriate.
authors.affiliation: Western Diagnostic Pathology, Symbion Health, Western Australia, Australia. sandieb@aapt.net.au
authors.forename: Sandie L
authors.initials: SL
authors.lastname: Barrett
authors.forename: Carol
authors.initials: C
authors.lastname: Bower
authors.forename: Narelle C
authors.initials: NC
authors.lastname: Hadlow
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D002869:Chromosome Aberrations; D000013:Congenital Abnormalities / Q000175:diagnosis; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis / Q000379:methods*; D016216:Ultrasonography, Prenatal; D014904:Western Australia / Q000453:epidemiology
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A