title: [Management of non-small cell lung carcinoma following docetaxel-cisplatin. Results of an epidemiologic survey].
abstract: BACKGROUND
  The purpose of this epidemiologic survey was to describe the management of second-line therapy for patients with stage IIIB-IV non-small cell lung carcinoma (NSCLC) following docetaxel-cisplatin as first-line therapy.
  
  
  METHODS
  Between June 2003 and December 2004, 265 patients were enrolled. The data registered were the choice of cytotoxics, the safety profile, the efficacy and the clinical benefit.
  
  
  RESULTS
  Two hundred and sixty one patients were treated with docetaxel-cisplatin as a first-line regimen and 181 received a second line. This second line was a single agent regimen in 58% of cases and a gemcitabine based treatment in 60.8%. The main criterion for the choice of second-line therapy was the safety profile in 34.3% of cases. The overall response rate was 16.6% after the second line and clinical benefit was reported in 43.6% of patients.
  
  
  CONCLUSIONS
  In more than 2/3 of patients with NSCLC the docetaxel-cisplatin combination leaves the opportunity to give a second-line treatment, providing satisfying results in terms of clinical benefit. In this study gemcitabine was the most widely prescribed second-line treatment, mainly as a single agent.
authors.affiliation: Centre Hospitalier, Belfort, France. pneumo.breton1@libertysurf.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Breton
authors.forename: G
authors.initials: G
authors.lastname: Robinet
authors.forename: E
authors.initials: E
authors.lastname: Dansin
authors.forename: M
authors.initials: M
authors.lastname: Rotarski
authors.forename: A
authors.initials: A
authors.lastname: Le Groumellec
authors.forename: L M
authors.initials: LM
authors.lastname: Dourthe
authors.forename: A
authors.initials: A
authors.lastname: Hamid
authors.forename: E
authors.initials: E
authors.lastname: Ecstein-Fraisse
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin