[Effect of omega-3 fatty acids on the lipid structure of HIV-positive patients on antiretroviral therapy: personal observation of 20 subjects].
Hyperlipidaemia related to antiretroviral therapy is a major issue in the management of HIV infection. In HIV positive patients, interventions on their lifestyles and dietary habits are only partially effective and pharmacological support is often required. However, fibrates and statins, interacting with antiretroviral therapy, may cause toxicity. A number of clinical trials have shown the effectiveness of omega-3 fatty acids on the hyperlipidaemia of HIV patients. In this study, the effect of six-month daily administration of omega-3 fatty acids on triglycerides, total and LDL cholesterol, and CD4 cell count was evaluated in a group of 20 HIV positive patients. Triglyceride levels significantly decreased, whilst total, LDL cholesterol and CD4 cell count did not vary. Fish oil therapy was well tolerated by all patients. Omega-3 fatty acids may contribute to reduce cardiovascular risk in HIV positive patients.
Ranieri
Roberto
R
Clinica Malattie Infettive e Tropicali, Ospedale San Paolo, Università degli Studi di Milano, Italy.
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003131:Combined Modality Therapy; D018752:Diet, Fat-Restricted; D004043:Dietary Fiber / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000178:diet therapy / Q000188:drug therapy*; D008297:Male
D019380:Anti-HIV Agents; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D015525:Fatty Acids, Omega-3; D002784:Cholesterol