title: Investigation of serrated roll surface differences on ribbon thickness during roller compaction.
abstract: Many parameters are considered when developing a roller compaction process. However, roll serration volume is generally not considered when using serrated rolls. It was hypothesized that serration volume of concavo-convex rolls can have a significant effect on ribbon thickness due to differences in nip angle. Experiments were conducted to investigate ribbon thickness using different roll sets having a range of serration volumes. Roll sets with approximately twice the serration volume produce ribbons 20-25% greater in thickness. These results correlated with physical measurements taken of the serrations from each set. Thus, differences in roll serration volume can significantly affect ribbon thickness.
authors.affiliation: Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340, USA. Patrick.D.Daugherity@Pfizer.com
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Daugherity
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Chu
mesh_terms: D011208:Powders; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D011208:Powders; D013607:Tablets