Development of viral vectors with optimal transgene expression for ocular gene therapies.
Striving for ideal viral constructs by modifying its structure, including promoters, would make the viral gene therapy more promising. Further assessment of the promoters and their expression profiles such as those shown in Table 1 and new designs of hybrid promoters may achieve optimal expression features for ocular gene therapies.
Hashimoto
Takao
T
Jules Stein Eye Institute, University of California Los Angeles, CA 90095, U.S.A. gbf00573@nifty.com
D005128:Eye Diseases / Q000628:therapy*; D015870:Gene Expression; D005814:Genes, Viral; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D011401:Promoter Regions, Genetic; D019076:Transgenes; D014780:Viruses / Q000235:genetics*