title: Cyclosporine induced neurotoxicity in a stem cell transplant recipient.
abstract: Neurological complications are quite frequent in stem cell transplant (SCT) recipients. Major causes are conditioning regimen toxicity, metabolic and electrolyte disturbances, viral infections and cyclosporine related toxicity. Cyclosporine induced neurotoxicity is a well documented complication in stem cell transplant recipients. These patients usually present with seizures which are easily controlled with anti-convulsants and by reducing/withholding the drug. However uncontrolled seizures requiring ventilatory support are rarely reported. Here we present a case report of cyclosporine induced uncontrolled seizures in a young female after allogeneic SCT which was unresponsive to anti-convulsive therapy but was successfully treated with mechanical ventilatory support.
authors.affiliation: Armed Forces Bone Marrow Transplant Centre, Rawalpindi.
authors.forename: Shahid
authors.initials: S
authors.lastname: Raza
authors.forename: Khalil
authors.initials: K
authors.lastname: Ullah
authors.forename: Parvez
authors.initials: P
authors.lastname: Ahmed
authors.forename: Tariq Mahmood
authors.initials: TM
authors.lastname: Satti
authors.forename: Muhammad Khalid
authors.initials: MK
authors.lastname: Kamal
authors.forename: Qamar-un-Nisa
authors.initials: QU
authors.lastname: Chaudhry
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells; D014180:Transplantation; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine