title: Recombinant factor VIIa for the prophylaxis of perioperative hemorrhage in a patient with congenital factor XI deficiency undergoing brain tumor neurosurgery.
abstract: The authors report on the first successful use of recombinant activated factor VII for the prophylaxis of bleeding during brain tumor neurosurgery in a patient suffering from inherited factor XI deficiency. Using the agent, surgery was performed without any bleeding complications. In this setting, off-label use of recombinant activated factor VII appears to be a promising alternative for patients suffering from this rare hemostatic defect with hitherto limited therapeutic options.
authors.affiliation: Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Moorenstrasse 5, Dusseldorf, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Sucker
authors.forename: Michael
authors.initials: M
authors.lastname: Sabel
authors.forename: Walter
authors.initials: W
authors.lastname: Stummer
authors.forename: Rainer B
authors.initials: RB
authors.lastname: Zotz
authors.forename: Ruediger E
authors.initials: RE
authors.lastname: Scharf
authors.forename: Andrea
authors.initials: A
authors.lastname: Gerhardt
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001932:Brain Neoplasms / Q000601:surgery*; D015942:Factor VIIa / Q000627:therapeutic use*; D005173:Factor XI Deficiency / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa