Reversible posterior leukoencephalopathy syndrome in 2 HIV-infected patients receiving antiretroviral therapy.
We describe 2 human immunodeficiency virus-infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syndrome with hypertension and endothelial damage. We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome.
Ridolfo
Anna Lisa
AL
Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy.
Resta
Federico
F
Milazzo
Laura
L
Caramma
Ilaria
I
Matacena
Giovanni
G
Antinori
Spinello
S
Galli
Massimo
M
D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000821:virology; D008297:Male; D008875:Middle Aged; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000821:virology*
D044966:Anti-Retroviral Agents