title: The use of marrow-derived stem cells to accelerate healing in chronic wounds.
abstract: Adult bone marrow-derived stem cells may aid the healing of chronic lower extremity wounds by transplanting a population of progenitor cells locally into the wound. We present results from three cases in which bone marrow aspirate containing marrow-derived cells was applied/injected locally into complex lower extremity chronic wounds of differing aetiologies. Our case series suggest that bone marrow aspirate, applied topically and injected into the wound periphery, may be a useful and potentially safe adjunct to wound simplification and ultimate closure.
authors.affiliation: Amputation Prevention Center, Broadlawns Medical Center, Des Moines, IA, USA.
authors.forename: Lee C
authors.initials: LC
authors.lastname: Rogers
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Bevilacqua
authors.forename: David G
authors.initials: DG
authors.lastname: Armstrong
mesh_terms: D000369:Aged, 80 and over; D016026:Bone Marrow Transplantation; D003929:Diabetic Neuropathies / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology / Q000628:therapy*