[Synthesis and antiviral activity of lupane triterpenoids with modified cycle E].
A reductive transformation of the peroxide products of ozonolysis of derivatives of 3beta-O-acetyl-22(17-->28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex.
Flekhter
O B
OB
Medvedeva
N I
NI
Kukovinets
O S
OS
Spirikhin
L V
LV
Galkin
E G
EG
Galin
F Z
FZ
Golovanov
D G
DG
Pavlova
N I
NI
Savinova
O V
OV
Boreko
E I
EI
Tolstikov
G A
GA
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002384:Catalysis; D006801:Humans; D029521:Alphainfluenzavirus / Q000187:drug effects*; D017975:Ruthenium Compounds / Q000737:chemistry; D012503:Saponins / Q000737:chemistry; D018139:Simplexvirus / Q000187:drug effects*; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
D000998:Antiviral Agents; D017975:Ruthenium Compounds; D012503:Saponins; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes; C027646:ruthenium tetraoxide