title: N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging.
abstract: This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37 degrees C. Nearly 8.53 +/- 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.
authors.affiliation: Department of Textile Engineering, Chonbuk National Univiversity, Jeonju, South Korea. khy@chonbuk.ac.kr.
authors.forename: Shanta R
authors.initials: SR
authors.lastname: Bhattarai
authors.forename: Remant B
authors.initials: RB
authors.lastname: Kc
authors.forename: Sun Y
authors.initials: SY
authors.lastname: Kim
authors.forename: Manju
authors.initials: M
authors.lastname: Sharma
authors.forename: Myung S
authors.initials: MS
authors.lastname: Khil
authors.forename: Pyoung H
authors.initials: PH
authors.lastname: Hwang
authors.forename: Gyung H
authors.initials: GH
authors.lastname: Chung
authors.forename: Hak Y
authors.initials: HY
authors.lastname: Kim