title: The Tasmanian Epilepsy Register--a community-based cohort. Background and methodology for patient recruitment from the Australian national prescription database.
abstract: OBJECTIVE
  Centralized prescription databases may provide an efficient mechanism for recruitment of community-treated disease.
  
  
  METHODS
  The Australian federal government agency, the Health Insurance Commission (HIC), invited patients to participate in the Tasmanian Epilepsy Register (TER). Eligible patients included those who received at least one anticonvulsant above a 'reportable' price threshold between July 1, 2001 and June 30, 2002. Patients were asked to disclose their medical indication for anticonvulsant treatment with additional demographic and prescription information obtained from the HIC.
  
  
  RESULTS
  7,541 were eligible for recruitment. After two mail invitations over 6 months, 3,375 (46.6%) had responded, but TER enrollment amongst those indicating treatment for epilepsy was 1,180 (78.3%). TER participants were more likely to obtain their prescriptions exclusively from their general practitioner (70.9%) or from combined sources (19.1%) rather than from pediatrician (4.2%), neurologist (1.4%) or general physician (1.0%) sources. Patients were more likely to respond with increasing age (linear trend p < 0.001), when from a higher socioeconomic area (linear trend p < 0.001), or if their prescription was obtained from a neurologist (p < 0.001).
  
  
  CONCLUSIONS
  The national Australian prescription database represents community-treated epilepsy and provides an effective and efficient method for patient recruitment for clinical epidemiological research.
authors.affiliation: Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia. dsouzaw@iprimus.com.au
authors.forename: Wendyl J
authors.initials: WJ
authors.lastname: D'Souza
authors.forename: Jayne L
authors.initials: JL
authors.lastname: Fryer
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Quinn
authors.forename: Bruce V
authors.initials: BV
authors.lastname: Taylor
authors.forename: David M
authors.initials: DM
authors.lastname: Ficker
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
authors.forename: Neil E
authors.initials: NE
authors.lastname: Pearce
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cook
mesh_terms: D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000627:therapeutic use*; D015331:Cohort Studies; D003153:Community Health Services / Q000706:statistics & numerical data; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004812:Epidemiologic Methods; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008511:Medicine / Q000706:statistics & numerical data; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D018579:Patient Selection; D011159:Population Surveillance; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012042:Registries; D012959:Socioeconomic Factors; D013038:Specialization; D013648:Tasmania
chemical_list: D000927:Anticonvulsants