Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
Thirty-two healthy volunteers with different SLCO1B1 genotypes ingested a 0.5-mg dose of repaglinide and 60-mg dose of nateglinide with a washout period of 1 week. Participants with SLCO1B1 c.521CC genotype (n = 4) had a 59% (P = 0.001) or 72% (P < 0.001) greater mean area under the plasma repaglinide concentration-time curve (AUC(0-infinity)) than participants with c.521TC (n = 12) or c.521TT (n = 16) genotypes. The AUC(0-infinity) of repaglinide metabolites M2 and M4 were 112% (P = 0.004) and 81% (P = 0.002) larger in participants with c.521CC genotype than in those with c.521TT genotype, but no differences existed in the pharmacokinetics of M1. Maximum decrease in blood glucose concentration correlated with repaglinide AUC(0-infinity) (r = 0.412, P = 0.019). SLCO1B1 polymorphism had no significant effect on the pharmacokinetics or pharmacodynamics of nateglinide or its M7 metabolite. Thus, in contrast to repaglinide, the disposition of nateglinide is unaffected by the SLCO1B1 c.521T>C polymorphism.
Kalliokoski
Annikka
A
Department of Clinical Pharmacology, Helsinki University Central Hospital, FIN-00029 HUS, Finland. mikko.niemi@helsinki.fi
Neuvonen
Mikko
M
Neuvonen
Pertti J
PJ
Niemi
Mikko
M
D000704:Analysis of Variance; D019540:Area Under Curve; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D002219:Carbamates / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D003510:Cyclohexanes / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D065727:Cytochrome P-450 CYP2C8; D065729:Cytochrome P-450 CYP2C9; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D006207:Half-Life; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D027381:Liver-Specific Organic Anion Transporter 1; D008657:Metabolic Clearance Rate; D015394:Molecular Structure; D000077715:Nateglinide; D027361:Organic Anion Transporters / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D010880:Piperidines / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D020641:Polymorphism, Single Nucleotide; D013607:Tablets; D053719:Tandem Mass Spectrometry
D001786:Blood Glucose; D002219:Carbamates; D003510:Cyclohexanes; D007004:Hypoglycemic Agents; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; D010880:Piperidines; C503999:SLCO1B1 protein, human; D013607:Tablets; D000077715:Nateglinide; D010649:Phenylalanine; C072379:repaglinide; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D065727:Cytochrome P-450 CYP2C8