C-reactive protein and acute coronary syndrome: comparison of conservative and interventional management.
BACKGROUND
Inflammation plays a key role in the initiation and progression of atherosclerosis, the most common cause of acute coronary syndrome. C-reactive protein (CRP) that enhances plaque inflammation is synthesized six hours after myocardial infarction.


METHODS
High sensitivity C-reactive protein was measured by Immunoturbiditory method in 50 healthy controls and 100 patients of acute coronary syndrome on conservative or interventional management.


RESULTS
Serum C-reactive protein levels [mg/L +/- SEM] at the time of admission were significantly raised in patients of acute coronary syndrome (11.90 +/- 2.30) as compared to controls (2.30 +/- 0.18) and further increased progressively during 24 hours of follow up period. C-reactive protein levels also increased significantly in patients who underwent interventional management (115.90 +/- 7.73) as compared to those who were on conservative management (22.28 +/- 5.54).


CONCLUSIONS
Serum C-reactive protein levels were found to be significantly raised in patients with acute coronary syndrome as compared to controls. In addition, patients undergoing interventional management had higher C-reactive protein levels, post intervention, as compared to those on conservative management.
Munir
Tahir Ahmad
TA
Section of Physiology, Shifa College of Medicine, Islamabad. tahirahmadmunir1@hotmail.com
Afzal
M Nasir
MN
D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D000789:Angina, Unstable; D002097:C-Reactive Protein; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D011379:Prognosis; D013997:Time Factors; D019210:Troponin I
D019210:Troponin I; D002097:C-Reactive Protein; D052279:Creatine Kinase, MB Form