Bronchus-associated lymphoid tissue lymphomas: an update of a rare extranodal maltoma.
Mucosa-associated lymphoid tissue (MALT) lymphomas were first described by Isaacson and Wright in 1983 in a small series of patients with low-grade B-cell gastrointestinal lymphomas. Although MALT lymphomas occur most frequently in the stomach, they have also been described in various non-gastrointestinal sites, such as the salivary gland, conjunctiva, thyroid, orbit, lung, breast, kidney, skin, liver, uterus, and prostate. The risk of a diagnostic dilemma is reduced by the favorable prognosis of this low-grade lymphoma and its tendency to remain localized to the primary site for a long time. On therapeutic grounds, in contrast to nodal lymphomas, low-grade MALT lymphomas also respond favorably to local treatments, such as surgery and/or local radiation therapy. The outcome and prognosis of low-grade MALT lymphomas are more favorable than those for other extranodal lymphomas. The purpose of this review is to point out the state of the art regarding bronchus-associated lymphoid tissues lymphomas in terms of etiology, pathogenesis, clinics, and therapeutics, including our single-center experience of 23 cases.
Zinzani
Pier Luigi
PL
Institute of Hematology and Medical Oncology, L. & A. Seràgnoli, University of Bologna, Italy. plzinzo@med.unibo.it
Poletti
Venerino
V
Zompatori
Maurizio
M
Tani
Monica
M
Spaggiari
Lucia
L
Tomassetti
Sara
S
Broccoli
Alessandro
A
Derenzini
Enrico
E
Baccarani
Michele
M
D001980:Bronchi / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009928:Organ Specificity; D017741:Survivors