Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma.
A 72-year-old man presented with erythema and induration of his calves and forearms. He had a past history of stage 1 colorectal carcinoma, treated with resection and primary anastamosis 4 years earlier. A diagnosis of eosinophilic fasciitis was made based on the characteristic clinical appearance, peripheral blood eosinophilia and a skin biopsy. There was no improvement in the condition following treatment with prednisolone or methotrexate. One year later, abnormal liver function studies were noted, and an abdominal computed tomography scan and subsequent needle biopsy of the liver confirmed a neoplastic lesion in the liver consistent with a metastatic colorectal carcinoma. Systemic chemotherapy with oxaliplatin, 5-fluorouracil and capecitabine was commenced, and resulted in partial remission of the colorectal carcinoma. Simultaneously, the indurations of the forearms and calves also improved, suggesting that the eosinophilic fasciitis was a paraneoplastic phenomenon.
Philpott
Hamish
H
Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, SA, Australia.
Hissaria
Pravin
P
Warrren
Lachlan
L
Singhal
Nimit
N
Brown
Michael
M
Proudman
Susanna
S
Cleland
Les
L
Gillis
David
D
D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D005208:Fasciitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000556:secondary; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000473:pathology