title: Practical, scalable, high-throughput approaches to eta3-pyranyl and eta3-pyridinyl organometallic enantiomeric scaffolds using the Achmatowicz reaction.
abstract: A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and TpMo(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Coombs
authors.forename: Maurice D
authors.initials: MD
authors.lastname: Lee
authors.forename: Heilam
authors.initials: H
authors.lastname: Wong
authors.forename: Matthew
authors.initials: M
authors.lastname: Armstrong
authors.forename: Bo
authors.initials: B
authors.lastname: Cheng
authors.forename: Wenyong
authors.initials: W
authors.lastname: Chen
authors.forename: Alessandro F
authors.initials: AF
authors.lastname: Moretto
authors.forename: Lanny S
authors.initials: LS
authors.lastname: Liebeskind
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D007536:Isomerism; D047028:Macrocyclic Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013696:Temperature
chemical_list: D001372:Aza Compounds; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D011725:Pyridines; C023666:pyridine