An unusual reaction of benzalaminoacetals in trifluoroacetic acid: facile synthesis of 2-benzylpyrazines.
Benzalaminoacetals (1), upon refluxing with trifluoroacetic acid, lead to 2-benzylpyrazines, rather than the expected isoquinolines. This unusual reaction represents another useful way to prepare a variety of 2-benzylpyrazines from the corresponding benzaldehydes.
Augustine
John Kallikat
JK
Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 100, India. john.kallikat@syngeneintl.com
Naik
Yanjerappa Arthoba
YA
Mandal
Ashis Baran
AB
Kundapur
Umesha
U
D000080:Acetals / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry*
D000080:Acetals; D011719:Pyrazines; D014269:Trifluoroacetic Acid; D001554:Benzene