Differential effects of psychological and physical stress on the sleep pattern in rats.
In the present study, we investigated the acute effects of 2 different kinds of stress, namely physical stress (foot shock) and psychological stress (non-foot shock) induced by the communication box method, on the sleep patterns of rats. The sleep patterns were recorded for 6 h immediately after 1 h of stress. Physical and psychological stress had almost opposite effects on the sleep patterns: In the physical stress group, hourly total rapid eye movement (REM) sleep and total non-REM sleep were significantly inhibited, whereas psychological stress enhanced hourly total REM sleep but not total non-REM sleep. Further results showed that total REM sleep, total non-REM sleep, total sleep and the total number of REM sleep episodes in 5 h were reduced, and that sleep latency was prolonged compared to the control group. On the other hand, in the psychological stress group, the total REM sleep in 5 h was increased significantly due to the prolongation of the average duration of REM sleep episodes and reduced REM sleep latency. In addition, the plasma of corticosterone increased significantly after physical stress but not after psychological stress. These results suggested that the sleep patterns, particularly the patterns of REM sleep following physical and psychological stress, are probably regulated by 2 different pathways.
Cui
Ranji
R
Department of Clinical Pharmacology and Pharmacy, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
Li
Bingjin
B
Suemaru
Katsuya
K
Araki
Hiroaki
H
D000818:Animals; D001921:Brain / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D004597:Electroshock; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012895:Sleep, REM / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*
D003345:Corticosterone