title: Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial.
abstract: Autologous stem cell therapy in the field of regenerative veterinary medicine involves harvesting tissue, such as fat, from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous adipose-derived stem cell therapy has been commercially available since 2003, and the current study evaluated such therapy in dogs with chronic osteoarthritis of the hip. Dogs treated with adipose-derived stem cell therapy had significantly improved scores for lameness and the compiled scores for lameness, pain, and range of motion compared with control dogs. This is the first randomized, blinded, placebo-controlled clinical trial reporting on the effectiveness of stem cell therapy in dogs.
authors.affiliation: Vet-Stem, Inc., Poway, CA 92064, USA. LBlack@vet-stem.com
authors.forename: Linda L
authors.initials: LL
authors.lastname: Black
authors.forename: James
authors.initials: J
authors.lastname: Gaynor
authors.forename: Dean
authors.initials: D
authors.lastname: Gahring
authors.forename: Cheryl
authors.initials: C
authors.lastname: Adams
authors.forename: Dennis
authors.initials: D
authors.lastname: Aron
authors.forename: Susan
authors.initials: S
authors.lastname: Harman
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Gingerich
authors.forename: Robert
authors.initials: R
authors.lastname: Harman
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D006619:Hip Dysplasia, Canine / Q000188:drug therapy* / Q000473:pathology; D007270:Injections, Intra-Articular / Q000662:veterinary; D007794:Lameness, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D012720:Severity of Illness Index; D014182:Transplantation, Autologous / Q000662:veterinary; D016896:Treatment Outcome; D014481:United States