Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta.
Eutherian placenta, an organ that emerged in the course of mammalian evolution, provides essential architecture, the so-called feto-maternal interface, for fetal development by exchanging nutrition, gas and waste between fetal and maternal blood. Functional defects of the placenta cause several developmental disorders, such as intrauterine growth retardation in humans and mice. A series of new inventions and/or adaptations must have been necessary to form and maintain eutherian chorioallantoic placenta, which consists of capillary endothelial cells and a surrounding trophoblast cell layer(s). Although many placental genes have been identified, it remains unknown how the feto-maternal interface is formed and maintained during development, and how this novel design evolved. Here we demonstrate that retrotransposon-derived Rtl1 (retrotransposon-like 1), also known as Peg11 (paternally expressed 11), is essential for maintenance of the fetal capillaries, and that both its loss and its overproduction cause late-fetal and/or neonatal lethality in mice.
Sekita
Yoichi
Y
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Wagatsuma
Hirotaka
H
Nakamura
Kenji
K
Ono
Ryuichi
R
Kagami
Masayo
M
Wakisaka
Noriko
N
Hino
Toshiaki
T
Suzuki-Migishima
Rika
R
Kohda
Takashi
T
Ogura
Atsuo
A
Ogata
Tsutomu
T
Yokoyama
Minesuke
M
Kaneko-Ishino
Tomoko
T
Ishino
Fumitoshi
F
D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D015415:Biomarkers / Q000378:metabolism; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D033481:Chromosomes, Mammalian; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D007150:Immunohistochemistry; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D035683:MicroRNAs / Q000378:metabolism; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010375:Pedigree; D010920:Placenta / Q000502:physiology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000502:physiology*; D018626:Retroelements / Q000502:physiology*; D014327:Trophoblasts / Q000378:metabolism
D015415:Biomarkers; D035683:MicroRNAs; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011257:Pregnancy Proteins; D018626:Retroelements; C526773:Rtl1 protein, mouse