Tandutinib inhibits FMS receptor signalling, and macrophage and osteoclast formation in vitro.
Brownlow
N
N
Vaid
M
M
Dibb
N J
NJ
D000818:Animals; D002460:Cell Line; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects* / Q000502:physiology; D010766:Phosphorylation; D010879:Piperazines / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects*
D007377:Interleukin-3; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D016173:Macrophage Colony-Stimulating Factor; C464670:tandutinib; D016186:Receptor, Macrophage Colony-Stimulating Factor