Clinical evaluations of OSTEON as a new alloplastic material in sinus bone grafting and its effect on bone healing.
OBJECTIVE
The objective of this study was to clinically evaluate the use of OSTEON as a sinus graft material and to measure the effect of healing at 4 and 6 months after surgery.


METHODS
After sinus graft using OSTEON in 17 patients, bone specimens were collected from lateral sinus using 2.0-mm trephine bur at the time of 4 or 6 months after surgery. Histology of the bone specimens was prepared and the percentage of newly formed bone fraction, lamellar bone/woven bone ratio (LB/WB), and newly formed bone/graft material ratio (NB/GM) were measured to indicate the suitability of the materials and the successful healing of the graft.


RESULTS
The morphology of OSTEON was observed to be interconnected, with 77% porosity and a pore size of 300-500 microm. After implantation, the mean percentage of newly formed bone fraction after 4 months and 6 months surgery was 40.6 and 51.9%, respectively. Statistical analysis indicated no significant difference (p = 0.135) in the newly formed bone fraction between the two postoperative periods. The mean LB/WB ratio after 4 months and 6 months surgery was 0.14 and 0.45, respectively, with significant difference observed between the two postoperative periods (p = 0.027). Additionally, the mean NB/GM ratio after 4 months and 6 months surgery was 1.95 and 7.72, respectively, with significant difference observed between the two postoperative periods (p = 0.046).


CONCLUSIONS
It was concluded that OSTEON is suitable for use in sinus graft application since desirable time-dependent healing was demonstrated.
Kim
Young-Kyun
YK
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seoul, Korea.
Yun
Pil-Young
PY
Lim
Sung-Chul
SC
Kim
Su-Gwan
SG
Lee
Hyo-Jung
HJ
Ong
Joo L
JL
D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000295:instrumentation* / Q000379:methods; D001842:Bone and Bones / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D015921:Dental Implants; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D010969:Plastics
D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D010969:Plastics; C485817:beta-tricalcium phosphate; D017886:Durapatite