Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines.
The immediate assessment of response to therapy is most beneficial to ovarian cancer patients. This study shows the correlation of drug-induced caspase activation determined by western blot analysis and by Caspase-Glotrade mark assay. Our findings demonstrate that the use of the Caspase-Glotrade mark assay allows a simple, fast, and sensitive alternative for the evaluation of in vitro response to chemotherapy.
Alvero
Ayesha B
AB
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Montagna
Michele K
MK
Mor
Gil
G
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020169:Caspases / Q000032:analysis / Q000378:metabolism*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D020169:Caspases