title: Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents.
abstract: An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe 85287-2404, USA. bpettit@asu.edu
authors.forename: George R
authors.initials: GR
authors.lastname: Pettit
authors.forename: Venugopal J R V
authors.initials: VJ
authors.lastname: Mukku
authors.forename: Gordon
authors.initials: G
authors.lastname: Cragg
authors.forename: Delbert L
authors.initials: DL
authors.lastname: Herald
authors.forename: John C
authors.initials: JC
authors.lastname: Knight
authors.forename: Cherry L
authors.initials: CL
authors.lastname: Herald
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Chapuis
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027844:Vitaceae / Q000737:chemistry*
chemical_list: C527627:22-epicalamistrin; D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic