The potential of nanoparticle-enhanced imaging.
Accurate lymph node staging in genitourinary malignancy is an important component in the diagnostic algorithm and therapeutic planning. A promising new method for lymph node staging is lymphotrophic nanoparticle enhanced magnetic resonance imaging. This novel technique uses ultrasmall superparamagnetic iron oxide particles, which localize in lymph nodes and provide detailed characterization of these nodes independent of typically accepted size criteria. This review provides a brief overview of the presently accepted methods for noninvasive lymph node staging and thoroughly discusses lymphotrophic nanoparticle enhanced MR imaging: a technique that can be used for accurate detection of lymph node metastases and will likely play a major role in noninvasive lymph node staging in genitourinary cancer in the near future.
Feldman
Adam S
AS
Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA. afeldman@partners.otg
McDougal
W Scott
WS
Harisinghani
Mukesh G
MG
D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008207:Lymphatic Metastasis / Q000473:pathology / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron / Q000379:methods; D053758:Nanoparticles; D009362:Neoplasm Metastasis; D014565:Urogenital Neoplasms / Q000175:diagnosis* / Q000473:pathology