[Methods and models for percutaneous absorption studies of organophosphates].
Organophosphates are highly toxic compounds, mainly penetrating the organism through the percutaneous route. In this context, having topical skin protectant capable of limitating their percutaneous penetration is of crucial importance for exposed people. Knowledge of the toxicokinetic parameters corresponding to the percutaneous penetration of these compounds is a key step for the development of these protective formulations. The different experimental approaches, in vivo and ex vivo, used to predict percutaneous penetration of these toxics are presented. The relevance and reliability of cutaneous experimental models are analysed.
Boudry
I
I
Centre de recherches du service de santé des armées, département de toxicologie, 24, avenue du Maquis-du-Grésivaudan, B.P. 87, 38702 La Tronche cedex, France. iboudry@crssa.net
Trescos
Y
Y
Vallet
V
V
Cruz
C
C
Lallement
G
G
D000279:Administration, Cutaneous; D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015194:Diffusion Chambers, Culture; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods; D006168:Guinea Pigs; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics* / Q000633:toxicity; D051379:Mice; D008954:Models, Biological; D016273:Occupational Exposure; D009924:Organ Culture Techniques / Q000295:instrumentation / Q000379:methods; D010755:Organophosphates / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D013552:Swine
D003879:Dermatologic Agents; D007306:Insecticides; D010755:Organophosphates