CD14(++)CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients.
Migration of monocytes into the vessel wall contributes to the onset and progression of atherosclerosis. Because monocytes are a heterogeneous population, we determined potential associations between monocyte subsets and cardiovascular events in a prospective cohort of 94 dialysis patients followed for 35 months. The incidence of cardiovascular events and death measured by Kaplan-Meier plots and flow cytometric analysis of monocyte subsets showed that total leukocyte and monocyte numbers failed to predict event-free survival. Among monocyte subsets, a high CD14(++)CD16(+) monocyte number was associated with higher rates of cardiovascular events and death. In a multivariate proportional hazards model adjusted for classical cardiovascular risk factors, patients with CD14(++)CD16(+) monocyte numbers in the top quartile were at higher risk of cardiovascular events and death compared to patients in the lowest quartile. Our study suggests that the number of CD14(++)CD16(+) monocytes was independently associated with cardiovascular events and death in a high-risk population of dialysis patients.
Heine
G H
GH
Department of Nephrology, University of Saarland, Homburg/Saar, Germany. inghei@uniklinik-saarland.de
Ulrich
C
C
Seibert
E
E
Seiler
S
S
Marell
J
J
Reichart
B
B
Krause
M
M
Schlitt
A
A
Köhler
H
H
Girndt
M
M
D000368:Aged; D050197:Atherosclerosis / Q000276:immunology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018950:Lipopolysaccharide Receptors / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011379:Prognosis; D017452:Receptors, IgG / Q000032:analysis*; D006435:Renal Dialysis; D016019:Survival Analysis
D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG