title: Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest.
abstract: Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212, USA.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Hou
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy
authors.initials: P
authors.lastname: Brodie
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Chris
authors.initials: C
authors.lastname: Birkinshaw
authors.forename: Fidisoa
authors.initials: F
authors.lastname: Ratovoson
authors.forename: Roland
authors.initials: R
authors.lastname: Rakotondrajaona
authors.forename: Rabodo
authors.initials: R
authors.lastname: Andriantsiferana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes