title: Chemical conjugation of muramyl dipeptide and paclitaxel to explore the combination of immunotherapy and chemotherapy for cancer.
abstract: Paclitaxel (Taxol) conjugated to muramyl dipeptide (MDP) is described. Biological testing showed that the conjugation of MDP at 2'-O-paclitaxel (2'- O -MTC-01) not only has antitumor activity, but also have immunoenhancement capacity. Compared with paclitaxel or MDP alone or with a mixture of paclitaxel + MDP, 2'- O -MTC-01 significantly increases the production and expression of TNF-alpha and IL-12 from mouse peritoneal macrophages, which demonstrates a synergism of MDP and paclitaxel in one conjugated molecule.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xuqin
authors.initials: X
authors.lastname: Li
authors.forename: Junli
authors.initials: J
authors.lastname: Yu
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Hongzhen
authors.initials: H
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yan
authors.forename: Guifang
authors.initials: G
authors.lastname: Cheng
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004359:Drug Therapy, Combination; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007167:Immunotherapy; D018664:Interleukin-12 / Q000235:genetics / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D017239:Paclitaxel