title: Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.
abstract: The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.
authors.affiliation: Department of Neurosurgery, Hacettepe University, Ankara, Turkey. gulsen.salih@gmail.com
authors.forename: Salih
authors.initials: S
authors.lastname: Gulsen
authors.forename: Servet
authors.initials: S
authors.lastname: Inci
authors.forename: Sinan
authors.initials: S
authors.lastname: Yuruk
authors.forename: Umit
authors.initials: U
authors.lastname: Yasar
authors.forename: Tuncalp
authors.initials: T
authors.lastname: Ozgen
mesh_terms: D000818:Animals; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D008297:Male; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000473:pathology; D020301:Vasospasm, Intracranial / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D004965:Estrogen Antagonists; D020849:Raloxifene Hydrochloride