Molecular mechanism of regulation of the calcium-binding protein calbindin-D9k, and its physiological role(s) in mammals: a review of current research.
Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium-binding protein that is expressed in a variety of tissues, such as uterus, placenta, intestine, kidney, pituitary gland and bone. At present, the precise role(s) of CaBP-9k remains to be clarified. CaBP-9k-null mice are normal, which indicates that other calcium-transporter genes can compensate for the lack CaBP-9k. Uterine CaBP-9k has been shown to be involved in the regulation of myometrial activity by intracellular calcium. In the uterus and placenta, CaBP-9k expression is regulated by the sex steroid hormones oestrogen (E2) and progesterone (P4). Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D. Thus, evidence to date suggests that CaBP-9k may be regulated in a tissue-specific manner. In this review, we will summarize current data on the molecular mechanism of regulation of CaBP-9k in mammals, including recent research data generated in our laboratories.
Choi
Kyung-Chul
KC
Department of Obstetrics and Gynecology, Faculty of Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.
Jeung
Eui-Bae
EB
D000818:Animals; D064026:Calbindins; D002118:Calcium / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008322:Mammals / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology / Q000502:physiology; D011485:Protein Binding; D064030:S100 Calcium Binding Protein G / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014018:Tissue Distribution; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology
D064026:Calbindins; D004967:Estrogens; D064030:S100 Calcium Binding Protein G; C576507:S100g protein, mouse; D011374:Progesterone; D002118:Calcium