title: Malignant fibrous histiocytoma of the parotid gland.
abstract: We described a rare malignant fibrous histiocytoma of the parotid gland (MFH) in a 63-year-old woman. During six months the tumour size became 10 cm in diameter with skin ulceration. The tumour was examined morphologically, by immunohistochemistry and molecular biology methods - FASAY and CGH. The histology revealed a storiform-pleomorphic type of MFH with high mitotic rate. The FASAY method identified a non-mutated p53 gene. The chromosomal changes were identified by the CGH method and 6 cytogenetic changes were found in the tumour cells (deletions at 8p12-p22, 13q32-qter, 14q24-qter, and gains of chromosomal material at 5p, 8q12-q23, and Xq25-qter). The patient died shortly after the beginning of chemotherapy. Autopsy revealed brain and cerebellar haemorrhage. No other tumour foci were proved. In view of short course of disease we lack the data about the influence of the non-mutated p53 gene on the prognosis and therapy.
authors.affiliation: Department of Pathology, Faculty of Medicine, Masaryk University in Brno, Faculty Hospital Brno, Czech Republic. jmacak@fnbrno.cz
authors.forename: J
authors.initials: J
authors.lastname: Macák
authors.forename: J
authors.initials: J
authors.lastname: Smardová
authors.forename: I
authors.initials: I
authors.lastname: Zavrelová
authors.forename: V
authors.initials: V
authors.lastname: Vránová
authors.forename: P
authors.initials: P
authors.lastname: Kuglík
mesh_terms: D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000737:chemistry / Q000473:pathology*