[Phagocytosis by neutrophils and monocytes in children with recurrent infections].
Phagocytosis by neutrophils and monocytes in 152 children suffering from recurrent infections, mean age 3 7/12 years, was investigated. The patients were divided in several groups according to severity and frequency of infections (A and B), age (<1 year, >1-2 years, >2 years) and a localization of infection (upper and low respiratory tract, otitis/otoantritis, multifocal). Healthy control (n=50) were of the same age as patients. The modification of opsonization test by Miller and the test of monocyte phagocytosis by Vujanovitsh were applied. Phagocytosis by neutrophils, due to disorder of opsonization, was significantly decreased in children with most frequent and severe infections (group B; p<0,05), in children older then 2 years, with less frequent and severe infections (p<0,05) and in those with upper resp. tract (p<0,01) and multifocal infections (P<0,05). Phagocytosis disorder was found in 10 (6,5%) patients (decreased opsonization in 8 and ingestion in 2). Phagocytosis was transient in 7/10 patients and permanent, due to primary opsonization disorder in 3/10. There was no significant difference in phagocytosis by monocytes Detween patients and controle. The short report of 10 patients with phagocytosis has been done.
Jovanović
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M
Vislavski
M
M
Jovanović
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M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D012008:Recurrence