A case of vanishing bile duct syndrome and IBD secondary to Hodgkin's lymphoma.
BACKGROUND
A 39-year-old man presented with a 2-month history of abdominal pain, jaundice, non-bloody diarrhea, weakness, and weight loss. Initial evaluation revealed intrahepatic ductopenia consistent with vanishing bile duct syndrome and IBD, type unclassified. Although treatment with budesonide improved his symptoms, they worsened several months later. On repeat evaluation, he was found to have extensive lymphadenopathy and an elevated white blood cell count.


METHODS
Physical examination, laboratory investigations, abdominal ultrasound, CT scans, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography, colonoscopies with biopsies, hepatic biopsy, axillary lymph node biopsy.


METHODS
Hodgkin's lymphoma with secondary vanishing bile duct syndrome and IBD, type unclassified.


RESULTS
The initial symptoms were managed with budesonide, but following recurrence, the patient's underlying lymphoma was treated with nitrogen mustard and dexamethasone.
DeBenedet
Anthony T
AT
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109-0368, USA. adebened@med.umich.edu
Berg
Carl L
CL
Enfield
Kyle B
KB
Woodford
Randall L
RL
Bennett
Audrey K
AK
Northup
Patrick G
PG
D000328:Adult; D001649:Bile Duct Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D013577:Syndrome