title: [Multicentric giant-cell tumor].
abstract: Nearly all (99) giant-cell tumors are solitary. The multicentric presentation is exceptional and not well elucidated. We report the case of a patient presenting five foci identified over an eleven-year period (right tibia, left 4th metacarpal, sacrum, right femur, left femur). The proliferation index was identified for each focus. A review of the literature shows that the development of a new center after treatment for giant-cell tumor is a well-known event, with a wide variability in localizations, number and time to development. The most recent data suggest that each center would be independent progressing according to an individual course. Since histological transformation is not observed and multicenter forms are very exceptional, we suggest that it would not be necessary to propose specific screening for patients with a giant-cell tumor but that it would be good to inform the patient of the possibility of multicentric presentations.
authors.affiliation: Service de Chirurgie Orthopédique et Traumatologique, Hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris. marc-antoine.rousseau@psl-aphp.fr
authors.forename: M-A
authors.initials: MA
authors.lastname: Rousseau
authors.forename: B
authors.initials: B
authors.lastname: Ilharreborde
authors.forename: F
authors.initials: F
authors.lastname: Larousserie
authors.forename: A
authors.initials: A
authors.lastname: Babinet
authors.forename: B
authors.initials: B
authors.lastname: Tomeno
authors.forename: P
authors.initials: P
authors.lastname: Anract
mesh_terms: D000328:Adult; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis*; D016025:Bone Transplantation; D003475:Curettage; D005266:Femoral Neoplasms / Q000175:diagnosis; D005870:Giant Cell Tumors / Q000175:diagnosis*; D006801:Humans; D008297:Male; D050279:Metacarpal Bones / Q000473:pathology; D012447:Sacrum / Q000473:pathology; D013125:Spinal Neoplasms / Q000175:diagnosis; D013977:Tibia / Q000473:pathology