title: Evaluation of screening tests for congenital cytomegalovirus infection.
abstract: Although the use of dried blood spots has been proposed for screening of newborns with congenital cytomegalovirus infection, viral loads in blood were significantly smaller than those in urine (P < 0.001), and DNA recovery from dried blood spots using the thermal shock procedure was inefficient. In contrast, our urine-based screening program identified asymptomatic cases with low viral loads in blood.
authors.affiliation: Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan. ninoue@nih.go.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.forename: Shin
authors.initials: S
authors.lastname: Koyano
mesh_terms: D003586:Cytomegalovirus Infections / Q000097:blood / Q000151:congenital* / Q000175:diagnosis* / Q000652:urine / Q000821:virology; D004279:DNA, Viral; D006801:Humans; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction / Q000379:methods; D019562:Viral Load
chemical_list: D004279:DNA, Viral