title: Escherichia coli serogroup O26--a new look at an old adversary.
abstract: Escherichia coli serogroup O26 played an important part in the early work on Verocytotoxin and is an established diarrhoeal pathogen. Recently, Verocytotoxigenic E. coli (VTEC) O26 has been increasingly associated with diarrhoeal disease and frequently linked to outbreaks and cases of haemolytic uraemic syndrome (HUS). This review investigates the pathogenicity, geographical distribution, changing epidemiology, routes of transmission and improved detection of VTEC O26. Laboratory data on VTEC O26 isolates and clinical data on HUS suggest a true difference in the incidence of VTEC O26 in different geographic locations. However, few diagnostic laboratories use molecular methods to detect VTEC and so it is difficult to assess the role of VTEC O26 in causing diarrhoeal disease. VTEC O26 is frequently found in the cattle population but rarely in food. However, the small number of outbreaks analysed to date are thought to be food-borne rather than associated with direct or indirect contact with livestock or their faeces. The increase in awareness of VTEC O26 in the clinical and veterinary setting has coincided with the development of novel techniques that have improved our ability to detect and characterize this pathogen.
authors.affiliation: Department of Medical Microbiology, Royal Free Hospital, NW3 2QG, London, UK. c.jenkins@medsch.ucl.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Jenkins
authors.forename: J
authors.initials: J
authors.lastname: Evans
authors.forename: H
authors.initials: H
authors.lastname: Chart
authors.forename: G A
authors.initials: GA
authors.lastname: Willshaw
authors.forename: G
authors.initials: G
authors.lastname: Frankel
mesh_terms: D000818:Animals; D002417:Cattle; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D054308:Enteropathogenic Escherichia coli / Q000302:isolation & purification / Q000472:pathogenicity; D004783:Environmental Microbiology; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D054323:Shiga-Toxigenic Escherichia coli / Q000302:isolation & purification / Q000472:pathogenicity