Epidemiology of an outbreak of chronic wasting disease on elk farms in Saskatchewan.
An outbreak of chronic wasting disease (CWD) in farmed elk in Saskatchewan from 1996 to 2002 was reviewed to 1, determine the progression of CWD from infection to death in farmed elk; 2, assess animal risk factors for CWD infection in farmed elk; 3, assess farm management and exposure risk factors for within herd CWD transmission; and 4, assess the suitability of the Canadian Food Inspection Agency's (CFIA) current disease control policy for CWD in light of the findings. The results from animal movement tracing, animal testing, and a farm management questionnaire were used. The duration of CWD (time from exposure to death of a CWD test-positive animal) was between a mean minimum of 19 months and a mean maximum of 40 months. Age and sex were not associated with CWD infection, except that adult elk (> or = 2 y) were more likely to be infected than young elk (< 18 mo) (RR = 2.3, 95% CI 1.6-3.5). Elk calves born in the last 18 mo prior to the death or diagnosis of their dam were at higher risk if their dams died of CWD (RR = 4.1, 95% CI 1.5-11.4) or exhibited clinical signs of CWD (RR = 8.3, 95% CI 2.7-25.7). Significant risk factors for transmission of CWD on elk farms were the introduction from an infected farm of trace-in elk that died of CWD (RR = 13.5, 95% CI 2.0-91) or developed clinical signs of CWD (RR = 7.1, 95% CI 0.93-54) and the elapsed time in years since the incursion of CWD (OR = 5.6, 95% CI 1.8-17.4). The assumptions on which CFIA's disease control policies were based were validated, but based on this new information, quarantine in cases where exposure to preclinical elk has occurred could be considered as an alternative to whole herd eradication.
Argue
Connie K
CK
Western Animal Health Program Network, Canadian Food Inspection Agency, Calgary, Alberta. cargue@inspection.gc.ca
Ribble
Carl
C
Lees
V Wayne
VW
McLane
Jim
J
Balachandran
Aru
A
D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D000829:Animals, Domestic; D000831:Animals, Newborn; D000835:Animals, Wild; D003670:Deer; D004196:Disease Outbreaks / Q000662:veterinary; D005260:Female; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012525:Saskatchewan / Q000453:epidemiology; D013997:Time Factors; D034081:Wasting Disease, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission*