title: A mechanism for arteriolar remodeling based on maintenance of smooth muscle cell activation.
abstract: Structural adaptation in arterioles is part of normal vascular physiology but is also seen in disease states such as hypertension. Smooth muscle cell (SMC) activation has been shown to be central to microvascular remodeling. We hypothesize that, in a remodeling process driven by SMC activation, stress sensitivity of the vascular wall is a key element in the process of achieving a stable vascular structure. We address whether the adaptive changes in arterioles under different conditions can arise through a common mechanism: remodeling in a stress-sensitive wall driven by a shift in SMC activation. We present a simple dynamic model and show that structural remodeling of the vessel radius by rearrangement of the wall material around a lumen of a different diameter and driven by differences in SMC activation can lead to vascular structures similar to those observed experimentally under various conditions. The change in structure simultaneously leads to uniform levels of circumferential wall stress and wall strain, despite differences in transmural pressure. A simulated vasoconstriction caused by increased SMC activation leads to inward remodeling, whereas outward remodeling follows relaxation of the vascular wall. The results are independent of the specific myogenic properties of the vessel. The simulated results are robust in the face of parameter changes and, hence, may be generalized to vessels from different vascular beds.
authors.affiliation: Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. jcbrings@mfi.ku.dk
authors.forename: Jens Christian Brings
authors.initials: JC
authors.lastname: Jacobsen
authors.forename: Michael John
authors.initials: MJ
authors.lastname: Mulvany
authors.forename: Niels-Henrik
authors.initials: NH
authors.lastname: Holstein-Rathlou
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001160:Arterioles / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology*; D032389:Myocytes, Smooth Muscle / Q000473:pathology*; D051381:Rats; D013314:Stress, Mechanical; D013997:Time Factors; D014661:Vasoconstriction; D014664:Vasodilation