title: Clinical report of three cases of acute radiation sickness from a (60)Co radiation accident in Henan Province in China.
abstract: On 26 April 1999, three persons were accidentally exposed by high dose (60)Co irradiation. They suffered from severe (one case) or moderate (two cases) hemopoietic form of acute radiation sickness (ARS). As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied. All the patients recovered after an appropriate treatment for 83 days. In our experience, the correct diagnosis and effective treatment at an early stage proved to be helpful to the patients in pulling out from the critical stage of acute radiation sickness. To avoid menstruation by the female patient just in the critical stage, we modified her menstruation cycle by testosterone. In our view, GM-CSF should be given as early as possible with enough dosage for promoting early hematological reconstruction. The experience obtained from the medical management of these patients is valuable for the treatment of such patients in the future.
authors.affiliation: Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine,l First Clinical Department of Chinese Center for Medical Response to Radiation Emergency, Tianjin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Wang
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Zhao
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Fu
authors.forename: Turai
authors.initials: T
authors.lastname: Istvan
authors.forename: Enhai
authors.initials: E
authors.lastname: Jiang
mesh_terms: D000328:Adult; D002648:Child; D002681:China; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000528:radiation effects; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology*; D018788:Radioactive Hazard Release; D012074:Remission Induction / Q000379:methods
chemical_list: D003037:Cobalt Radioisotopes; D016178:Granulocyte-Macrophage Colony-Stimulating Factor