title: PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.
abstract: Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P approximately PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD-PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P approximately PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.
authors.affiliation: Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Wuming
authors.initials: W
authors.lastname: Gong
authors.forename: Dihan
authors.initials: D
authors.lastname: Zhou
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Ren
authors.forename: Yejun
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zuo
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shen
authors.forename: Feifei
authors.initials: F
authors.lastname: Xiao
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhu
authors.forename: Ailing
authors.initials: A
authors.lastname: Hong
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Gao
authors.forename: Tongbin
authors.initials: T
authors.lastname: Li
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping; D014584:User-Computer Interface
chemical_list: D010750:Phosphoproteins