A morphometric and histological study of the kidney of mice after dermal application of cypermethrin.
OBJECTIVE
To assess dose related toxic effects of Cypermethrin, a new synthetic pyrethroid insecticide, on the mammalian kidney.


METHODS
The study was conducted at Khyber Medical College, Peshawar, in the year 2001, 2002. Adult albino mice (6-8 weeks old) were used for the study. Cypermethrin was administered in doses of 15 mg/kg body weight and 30 mg/kg bodyweight as a single daily dermal application for a period of 6 weeks. At the end of the 6th week, all the animals were sacrificed, their kidneys were dissected out and fixed in 10% neutral buffered formalin and processed for histological studies.


RESULTS
There was congestion of vessels and marked lymphocytic infiltration (more than 50 lymphocytes/HPF) in the kidneys of the experimental group receiving 30 mg/kg body weight of Cypermethrin, while no abnormality was observed in the animals receiving 15 mg/kg body weight of Cypermethrin and in the animals of the control group.


CONCLUSIONS
Cypermethrin is toxic to mammals. It causes marked lymphocytic infiltration and congestion of vessels in the kidneys. The industrial workers exposed to Cypermethrin are also liable to get similar nephrotoxicity, after repeated exposure. However, the magnitude of the injury and its reversibility have not been assessed in the humans. This pilot project has established nephrotoxicity of Cypermethrin after dermal exposure, a route that predisposes industrial workers to toxicity.
Inayat
Qaiser
Q
Ilahi
Maqbool
M
Khan
Jehanzeb
J
D000279:Administration, Cutaneous; D000818:Animals; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D011722:Pyrethrins / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin