title: Cutaneous penile and perianal Crohn's disease treated with a combination of medical and surgical interventions.
abstract: A 73-year-old man presented with fistulizing cutaneous Crohn's disease of the penis and perianal area without involvement of the gastrointestinal tract. The disease failed to respond to topical clobetasol propionate and oral cyclosporin and methotrexate. A combination treatment of minocycline, thalidomide and prednisolone brought the disease under control and induced remission. Surgery with excision and skin grafting were required to produce cure.
authors.affiliation: Department of Dermatology, Aberdeen Royal Infirmary, Fosterhill, Aberdeen, UK. sanjaysunil@yahoo.com
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Rajpara
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Siddha
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Ormerod
authors.forename: Keith M
authors.initials: KM
authors.lastname: Kerr
authors.forename: Prahalad S
authors.initials: PS
authors.lastname: Kolhe
mesh_terms: D000368:Aged; D001003:Anal Canal / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D017577:Cutaneous Fistula / Q000209:etiology; D062109:Dermatologic Surgical Procedures; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D010409:Penile Diseases / Q000628:therapy*; D010413:Penis / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000473:pathology*; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D014548:Urinary Fistula / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents