Therapeutic experience of Bing-Neel Syndrome associated with Waldenstrom's macroglobulinemia.
Waldenstrom's macroglobulinemia is an uncommon low-grade B-cell lymphoproliferative disorder in which monoclonal immunoglobulin M is produced. Neurological symptoms due to hyperviscosity are frequent manifestations of Waldenstrom's macroglobulinemia. However, central nervous system infiltration by plasmacytoid lymphocytes (Bing-Neel syndrome) has only rarely been reported. We report a case of a 51-yr-old woman suffering from Waldenstrom's macroglobulinemia who complained of persistant headache. Brain magnetic resonance imaging revealed an extra-axial soft tissue mass along the left cavernous sinus, left tentorium, right tentorium, and falx cerebri. A stereotactic biopsy of dural tissue from the falx was performed and showed plasmacytoid lymphocyte infiltration. The patient became symptom- free with irradiation of the whole brain followed by chemotherapy with fludarabine.
Kim
Hyun Do
HD
Department of Internal Medicine, Yeoungnam University College of Medicine, Daegu, Korea.
Shin
Kyeong Cheol
KC
Cho
Hee Soon
HS
Kim
Min Kyoung
MK
Lee
Kyung Hee
KH
Hyun
Myung Soo
MS
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000209:etiology / Q000628:therapy*; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D000069283:Rituximab; D013577:Syndrome; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014740:Vidarabine; C024352:fludarabine