title: Mid-infrared optical coherence tomography.
abstract: A time domain optical coherence tomography (OCT) system is described that uses mid-infrared light (6-8 microm). To the best of our knowledge, this is the first OCT system that operates in the mid-infrared spectral region. It has been designed to characterize bioengineered tissues in terms of their structure and biochemical composition. The system is based upon a free-space Michelson interferometer with a germanium beam splitter and a liquid nitrogen cooled HgCdTe detector. A key component of this work has been the development of a broadband quantum cascade laser source (InGaAs/AlInAs containing 11 different active regions of the three well vertical transition type) that emits continuously over the 6-8 microm wavelength range. This wavelength range corresponds to the so called "mid-infrared fingerprint region" which exhibits well-defined absorption bands that are specifically attributable to the absorbing molecules. Therefore, this technology provides an opportunity for optical coherence molecular imaging without the need for molecular contrast agents. Preliminary measurements are presented.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Colley
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.forename: David T
authors.initials: DT
authors.lastname: Delpy
authors.forename: Alison D
authors.initials: AD
authors.lastname: Cambrey
authors.forename: Robert A
authors.initials: RA
authors.lastname: Brown
authors.forename: Evgeny A
authors.initials: EA
authors.lastname: Zibik
authors.forename: Wing H
authors.initials: WH
authors.lastname: Ng
authors.forename: Luke R
authors.initials: LR
authors.lastname: Wilson
authors.forename: John W
authors.initials: JW
authors.lastname: Cockburn
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D007259:Infrared Rays; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*