title: Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia.
abstract: OBJECTIVE
  Desquamative interstitial pneumonia (DIP) is a rare pattern of diffuse parenchymal lung disease known to overlap with respiratory bronchiolitis-interstitial lung disease (RB-ILD). The aim was to review biopsy-proven cases of DIP to investigate further the clinical, imaging and histological features of this disease.
  
  
  RESULTS
  Twenty patients fulfilled the pathological criteria: 19 men and one woman with a mean age of 54 years. Clinical features, bronchoalveolar lavage (BAL) data, radiological findings, pathological findings other than criteria, effect of therapy and outcome were examined. The BAL data for 17 cases revealed marked eosinophilia (mean 18%) and moderate neutrophilia (mean 11%). Computed tomography in 17 patients showed peripheral involvement in all cases with a clear margin in 64% and thin-walled cysts in 35% of cases. Additional pathological features were a distinct lobular distribution (70%) and architectural destruction (70%) with cyst formation (55%). Eighteen of the 19 patients (95%) improved under steroid pulse and/or oral therapy. Sixteen subjects (80%) are alive, three died of other diseases and one died of DIP 74 months after the diagnosis. Percent vital capacity increased significantly and new thin-walled cysts appeared in one case.
  
  
  CONCLUSIONS
  BAL eosinophilia, lobular distribution and architectural destruction with cyst formation are characteristic features of DIP.
authors.affiliation: Division of Pathology, Saitama Cardiovascular Respiratory Centre, Ohsato, Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabata
authors.forename: T
authors.initials: T
authors.lastname: Takemura
authors.forename: A
authors.initials: A
authors.lastname: Hebisawa
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
authors.forename: S
authors.initials: S
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Sakatani
authors.forename: K
authors.initials: K
authors.lastname: Chida
authors.forename: F
authors.initials: F
authors.lastname: Sakai
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: T V
authors.initials: TV
authors.lastname: Colby
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001784:Blood Gas Analysis; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed