title: Pim2 inhibitors from the Papua New Guinean plant Cupaniopsis macropetala.
abstract: Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine ( 1), together with the known flavonoid glycoside quercitrin ( 2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC 50 values of 161 and 25 microM, respectively, in a Pim2 enzyme assay.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Australia.
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Moana M
authors.initials: MM
authors.lastname: Simpson
authors.forename: Ryan B
authors.initials: RB
authors.lastname: Nugent
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Topul
authors.initials: T
authors.lastname: Rali
authors.forename: Huawei
authors.initials: H
authors.lastname: Chen
authors.forename: Barbara
authors.initials: B
authors.lastname: Qurallo
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D010219:Papua New Guinea; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C490587:PIM2 protein, human; D011518:Proto-Oncogene Proteins; C529037:galloyl tyramine; C012526:quercitrin; D005707:Gallic Acid; D011794:Quercetin; D017346:Protein Serine-Threonine Kinases; D014439:Tyramine