Effect of tiaozhi yanggan decoction in treating patients with non-alcoholic fatty liver.
OBJECTIVE
To observe the clinical efficacy and safety of Tiaozhi Yanggan Decoction (TZYGD) in treating non-alcoholic fatty liver.


METHODS
One hundred and thirty-eight patients were enrolled and randomized into two groups according to the random number table in a ratio of 3:1, with 8 cases eventually dropping out. The symptoms, signs, liver function markers, blood lipids, iconographic indices and clinical comprehensive efficacy after a 12-week treatment course were assessed in 101 patients treated with TZYGD in the treated group and 29 patients treated with Thiola in the control group.


RESULTS
The total effective rate in the treated group and the control group was 81.19% and 68.97%, respectively, showing a significant difference between the two groups with the former being significantly higher than the latter (P<0.05). Moreover, the improvements in the symptoms, signs, liver function, blood lipids and iconographic indices in the treated group were favorable with no serious adverse reactions.


CONCLUSIONS
TZYGD is effective and highly safe in treating non-alcoholic fatty liver.
Gu
Can-li
CL
People's Hospital of Ruyang County, Henan Province, 471200, China. gcl8007@163.com
Zhang
Yun-ke
YK
Fu
Yue-xiao
YX
Yang
Shao-feng
SF
Li
Xin-qiang
XQ
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008099:Liver / Q000503:physiopathology; D008297:Male; D008516:Medicine, Chinese Traditional / Q000009:adverse effects / Q000379:methods; D008875:Middle Aged; D008517:Phytotherapy / Q000009:adverse effects; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D008055:Lipids