title: Influence of hydrochlorothiazide on urinary calcium oxalate relative supersaturation in healthy young adult female domestic shorthaired cats.
abstract: Hydrochlorothiazide (1 mg/kg PO q12h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received hydrochlorothiazide, 24-hour urine volume, ammonia, chloride, creatinine, magnesium, oxalic acid, phosphate, potassium, and sodium were significantly higher than when cats received placebo. Hydrochlorothiazide was associated with significantly lower urinary saturation for calcium oxalate, but no difference was found in 24-hour urine calcium and citrate, urinary saturation for struvite, or blood ionized calcium. Hydrochlorothiazide decreased urinary saturation for calcium oxalate and could be useful in managing cats with calcium oxalate uroliths. Results of this study, however, should not be extrapolated to cats that form calcium oxalate uroliths.
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee, Knoxville 37996-4544, USA.
authors.forename: Alisha
authors.initials: A
authors.lastname: Hezel
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Bartges
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Kirk
authors.forename: Sherry
authors.initials: S
authors.lastname: Cox
authors.forename: Nicole
authors.initials: N
authors.lastname: Geyer
authors.forename: Tammy
authors.initials: T
authors.lastname: Moyers
authors.forename: Jimmy
authors.initials: J
authors.lastname: Hayes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002129:Calcium Oxalate / Q000097:blood / Q000652:urine*; D002371:Cat Diseases / Q000652:urine; D002415:Cats; D018592:Cross-Over Studies; D005260:Female; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology*; D017616:Magnesium Compounds / Q000652:urine*; D010710:Phosphates / Q000652:urine*; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000069877:Struvite; D016896:Treatment Outcome; D016482:Urinalysis / Q000662:veterinary; D014545:Urinary Calculi / Q000652:urine / Q000662:veterinary
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D002129:Calcium Oxalate; D000069877:Struvite