A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line.
This paper reports on the preparation of a water-soluble nanoemulsion of the highly lipid-soluble drug tamoxifen (TAM). In addition, relative to a suspension of TAM, the nanoemulsion preparation demonstrated a greater zeta potential (increased negative charge) which has previously been associated with increasing drug/membrane permeability. This study also reports that relative to suspensions of TAM with particle sizes greater than 6000 nm, nanoemulsions of TAM, having mean particle sizes of 47 nm, inhibited cell proliferation 20-fold greater and increased cell apoptosis 4-fold greater in the HTB-20 breast cancer cell line. Thus, this work suggests that a nanoemulsion compared to a suspension preparation of TAM increases its anticancer properties relative to breast cancer.
Tagne
Jean-Bosco
JB
Center for Health and Disease Research, University of Massachusetts-Lowell, Lowell, Massachusetts 01854, USA.
Kakumanu
Srikanth
S
Ortiz
Daniela
D
Shea
Thomas
T
Nicolosi
Robert J
RJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D005260:Female; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D013629:Tamoxifen / Q000008:administration & dosage* / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
D004655:Emulsions; D013629:Tamoxifen