title: Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss.
abstract: OBJECTIVE
  To investigate the association of the common protein Z (PZ) intron F G79A gene polymorphism with recurrent early pregnancy loss (RPL) and its gene-gene interaction with known thrombophilic risk factors for RPL.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  University clinic.
  
  
  METHODS
  We enrolled 49 women with a history of two consecutive or three to six nonconsecutive pregnancy losses between the 8th and 12th weeks of gestation and 48 age-matched parous controls without a history of pregnancy complications.
  
  
  METHODS
  None.
  
  
  METHODS
  Allele frequencies of the PZ intron F G79A polymorphism and its gene-gene interaction with known risk factors for RPL.
  
  
  RESULTS
  Fourteen case subjects (28.6%) and 24 control subjects (50.0%) carried at least one A allele. This was associated with a significant reduction of the relative risk for recurrent pregnancy loss (odds ratio [OR] 0.4, 95% confidence interval [CI] 0.2-0.9; adjusted OR 0.3, 95% CI 0.1-0.8). Coexistence of any thrombophilic risk factor studied with the 79A allele resulted in a clear reduction of the primal relative risk for recurrent pregnancy loss.
  
  
  CONCLUSIONS
  The isolated presence of the PZ intron F 79A allele as well as the combination with known thrombophilic risk factors was protective against RPL between the 8th and 12th weeks of gestation.
authors.affiliation: Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
authors.forename: Astrid
authors.initials: A
authors.lastname: Dossenbach-Glaninger
authors.forename: Michael
authors.initials: M
authors.lastname: van Trotsenburg
authors.forename: Hanns
authors.initials: H
authors.lastname: Helmer
authors.forename: Christian
authors.initials: C
authors.lastname: Oberkanins
authors.forename: Pierre
authors.initials: P
authors.lastname: Hopmeier
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D001798:Blood Proteins; C026080:plasma protein Z