Hybrid mass spectrometers for tandem mass spectrometry.
Mass spectrometers that use different types of analyzers for the first and second stages of mass analysis in tandem mass spectrometry (MS/MS) experiments are often referred to as "hybrid" mass spectrometers. The general goal in the design of a hybrid instrument is to combine different performance characteristics offered by various types of analyzers into one mass spectrometer. These performance characteristics may include mass resolving power, the ion kinetic energy for collision-induced dissociation, and speed of analysis. This paper provides a review of the development of hybrid instruments over the last 30 years for analytical applications.
Glish
Gary L
GL
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, USA. glish@unc.edu
Burinsky
David J
DJ
D001363:Awards and Prizes; D004867:Equipment Design; D053719:Tandem Mass Spectrometry / Q000295:instrumentation* / Q000379:methods / Q000639:trends*; D019789:Tetraethylammonium / Q000032:analysis
D019789:Tetraethylammonium