title: An unusual reaction of benzalaminoacetals in trifluoroacetic acid: facile synthesis of 2-benzylpyrazines.
abstract: Benzalaminoacetals (1), upon refluxing with trifluoroacetic acid, lead to 2-benzylpyrazines, rather than the expected isoquinolines. This unusual reaction represents another useful way to prepare a variety of 2-benzylpyrazines from the corresponding benzaldehydes.
authors.affiliation: Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 100, India. john.kallikat@syngeneintl.com
authors.forename: John Kallikat
authors.initials: JK
authors.lastname: Augustine
authors.forename: Yanjerappa Arthoba
authors.initials: YA
authors.lastname: Naik
authors.forename: Ashis Baran
authors.initials: AB
authors.lastname: Mandal
authors.forename: Umesha
authors.initials: U
authors.lastname: Kundapur
mesh_terms: D000080:Acetals / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000080:Acetals; D011719:Pyrazines; D014269:Trifluoroacetic Acid; D001554:Benzene