title: [Fetal death following high-dose systemic steroid therapy in a pregnant patient with Vogt-Koyanagi-Harada disease].
abstract: BACKGROUND
  In previous reports, all pregnant women with VKH were successfully treated in the second or third trimester with high-dose systemic corticosterioids without any severe complications. We present a case of fetal death during systemic steroid treatment of a VKH disease patient.
  
  
  RESULTS
  A 28-year-old woman in the 30th week of pregnancy was diagnosed with VKH disease. Because of the progression to high bullous retinal detachment in spite of topical corticosteroid therapy, systemic intravenous prednisolone (PSL, 200 mg/day) was begun. On day 18 (PSL, 55 mg/day), sudden intrauterine fetal death occurred. Maternal conditions were normal and there was no apparent abnormality in the umbilical cord, placenta, or fetus; no autopsy was allowed. With gradual tapering of the PSL, the patient's vision was preserved, without recurrence of the VKH disease.
  
  
  CONCLUSIONS
  We present a case of fetal death in a 28-year-old pregnant woman being treated with intravenous prednisolone for VKH disease. The cause of the fetal death was not clear. It was reported as an adverse event.
authors.affiliation: Department of Ophthalmology, Shinshu University School of Medicine, Japan. kohta@hsp.md.shinshu-u.ac.jp
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ohta
authors.forename: Norimoto
authors.initials: N
authors.lastname: Gotoh
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yonezawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Oka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ashida
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014607:Uveomeningoencephalitic Syndrome / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone