Cutaneous Aspergillus ustus in a lung transplant recipient: emergence of a new opportunistic fungal pathogen.
Opportunistic fungal infections remain a significant complication in immunosuppressed patients, especially those having undergone solid-organ transplantation. We report a 39-year-old patient who represents the second case of cutaneous Aspergillus ustus infection in a solid-organ transplant recipient, and the first documented case after lung transplantation. The patient's cutaneous lower extremity aspergillosis responded to a combination of intravenous liposomal amphotericin B, caspofungin and topical terbinafine cream, with a concomitant reduction in immunosuppression. A. ustus is an emerging opportunistic fungal pathogen in transplant recipients.
Vagefi
Parsia A
PA
Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Cosimi
A Benedict
AB
Ginns
Leo C
LC
Kotton
Camille N
CN
D000328:Adult; D001228:Aspergillosis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D001230:Aspergillus / Q000302:isolation & purification*; D001706:Biopsy; D003881:Dermatomycoses / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000150:complications*; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D019896:alpha 1-Antitrypsin Deficiency / Q000601:surgery*