Stem cell differentiation: cardiac repair.
Cellular transplantation has been employed for several years to deliver donor cardiomyocytes to normal and injured hearts. Recent reports of a variety of stem cells with apparent cardiomyogenic potential have raised the possibility of cell transplantation-based therapeutic interventions for heart disease. Here we review the preclinical studies demonstrating that intracardiac transplantation of skeletal myoblasts, cardiomyocytes and cardiomyogenic stem cells is feasible. In addition, recent clinical studies of skeletal myoblast and adult stem cell transplantation for heart disease are discussed.
Rubart
Michael
M
Division of Pediatric Cardiology, Herman B Wells Center for Pediatric Research, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Field
Loren J
LJ
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D032448:Myoblasts, Skeletal / Q000637:transplantation; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000637:transplantation; D013234:Stem Cells / Q000166:cytology*; D014945:Wound Healing