Dynamic combinatorial chemistry: on the road to fulfilling the promise.
Dynamic combinatorial chemistry makes use of reversible reactions between functionalised monomeric building blocks to generate a mixture of products (dimers or oligomers) under thermodynamic equilibrium. This system reorganises upon addition of a target so that species that bind to, and are therefore stabilised by the target, are favourably formed and are thus amplified. Since the mid-1990's, dynamic combinatorial chemistry has been successfully applied to the identification/selection of ion receptors, enzyme inhibitors, catalysts, materials and nucleic acid ligands. Although it is now established as a powerful tool with broad applications some intrinsic limitations appeared when working on systems of increasing complexity. We present here the most recent advances in the field of dynamic combinatorial chemistry that have been developed to overcome these limitations and explore new areas of application.
Ladame
Sylvain
S
Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, CNRS UMR 7006, 8, allée Gaspard Monge, BP 70028, 67083 Strasbourg Cédex, France. s.ladame@isis.u-strasbg.fr
D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000235:genetics; D015374:Biosensing Techniques; D004396:Coloring Agents / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry / Q000235:genetics; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D052157:Aptamers, Nucleotide; D004396:Coloring Agents; D008024:Ligands; D009942:Organometallic Compounds; D012313:RNA; D004247:DNA