title: An efficient method for the synthesis of nitropiperidones.
abstract: A three step efficient strategy for the synthesis of substituted 5-nitropiperidones in high de, employing Michael addition of N-p-tolylsulfinyl beta-nitroamines to alpha,beta-unsaturated esters, hydrolysis of the sulfinyl group, and cyclization of the resulting free amines, has been developed. A very simple experimental procedure involving mild conditions and only one chromatographic purification are the main features of the process.
authors.affiliation: Departamento de Química OrgAnica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: José Luis García
authors.initials: JL
authors.lastname: Ruano
authors.forename: Teresa de
authors.initials: Td
authors.lastname: Haro
authors.forename: Rajinder
authors.initials: R
authors.lastname: Singh
authors.forename: M Belén
authors.initials: MB
authors.lastname: Cid
mesh_terms: D003500:Cyclization; D017611:Fluorine Compounds / Q000138:chemical synthesis / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D017611:Fluorine Compounds; D009574:Nitro Compounds; D010881:Piperidones