Biochemical markers predictive for bone marrow involvement in systemic mastocytosis.
Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic mastocytosis, of whom 63 ultimately had bone marrow involvement. Patients suspected of aggressive mastocytosis, or mastocytosis associated with other hematologic diseases were excluded. Evaluation of 115 patients and 15 patient controls demonstrated a test accuracy for serum tryptase, urinary N(-) methylhistamine and N(-) methylimidazole acetic acid of 96%, 88% and 95% respectively. These markers provide an excellent pre-test probability of indolent systemic mastocytosis.
Donker
Marjolein L
ML
Department of Internal Medicine Hematology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
van Doormaal
Jasper J
JJ
van Doormaal
Frederiek F
FF
Kluin
Philip M
PM
van der Veer
Eveline
E
de Monchy
Jan G R
JG
Kema
Ido P
IP
Kluin-Nelemans
Hanneke C
HC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000737:chemistry; D001853:Bone Marrow / Q000378:metabolism*; D002624:Chemistry, Clinical / Q000379:methods*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008297:Male; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000378:metabolism*; D008761:Methylhistamines / Q000652:urine; D008875:Middle Aged; D053802:Tryptases / Q000097:blood
D015415:Biomarkers; D007093:Imidazoles; D008761:Methylhistamines; C002667:methylimidazoleacetic acid; D053802:Tryptases; C048140:N-methylhistamine