The two sides of hippocampal mossy fiber plasticity.
Two studies in this issue of Neuron (Kwon and Castillo and Rebola et al.) show that the mossy fiber-CA3 pyramidal neuron synapse, a hippocampal synapse well known for its presynaptic plasticity, exhibits a novel form of long-term potentiation of NMDAR-mediated currents, which is induced and expressed postsynaptically.
Kerr
Angharad M
AM
Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.
Jonas
Peter
P
D000818:Animals; D008954:Models, Biological; D019599:Mossy Fibers, Hippocampal / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate