title: Management of locally invasive well-differentiated thyroid cancer.
abstract: Thyroid carcinoma invasion of the aerodigestive tract and recurrent laryngeal nerve (RLN) are important factors with increase in morbidity and mortality. Primary treatment is surgery; the decision about the extent of surgery is difficult, because preserving function is as essential as removal of the tumor. This article discusses the literature relating to the assessment of disease, surgical management, and adjuvant therapy for invasive thyroid cancer of the aerodigestive tract and RLN and makes suggestions based on the authors' experience.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.
authors.forename: Nebil
authors.initials: N
authors.lastname: Ark
authors.forename: Sessunu
authors.initials: S
authors.lastname: Zemo
authors.forename: David
authors.initials: D
authors.lastname: Nolen
authors.forename: F Christopher
authors.initials: FC
authors.lastname: Holsinger
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
mesh_terms: D018450:Disease Progression; D006801:Humans; D007830:Larynx / Q000601:surgery; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D014132:Trachea / Q000601:surgery