title: Novel approaches to the treatment of cachexia.
abstract: Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others. The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
authors.affiliation: Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain. jargiles@ub.edu
authors.forename: Josep M
authors.initials: JM
authors.lastname: Argilés
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Soriano
authors.forename: Sílvia
authors.initials: S
authors.lastname: Busquets
mesh_terms: D019167:Appetite Stimulants / Q000627:therapeutic use; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D019247:HIV Wasting Syndrome / Q000150:complications / Q000378:metabolism; D006333:Heart Failure / Q000150:complications / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000378:metabolism
chemical_list: D019167:Appetite Stimulants