title: [The effects of various doses of intrathecal morphine in addition with ropivacaine in combined spinal-epidural technique for labour analgesia].
abstract: We evaluated the duration of analgesia, side effects and neonatal effects of intrathecal ropivacaine combined with two different doses of morphine using combined spinal epidural (CSE) technique for labour analgesia. Fourty term parturients were enrolled. Group I received 0,2% ropivacaine 3 mg + morphine 50 microg and Group II received 0,2% ropivacaine 3 mg + morphine 100 microg intrathecally. When VAS for pain was equal or above 30 mm, PCEA(Patient controlling epidural analgesia) was started using 0,1% ropivacaine. There wasn't any statistical significant difference considering the duration of analgesia between two groups. The first stage of labour was significantly shorter in Group II then Group I, and the epidural local anaesthetic volume was significantly lower in Group II. The most common side effect in both groups was pruritus. There was not any side effect of local anaesthetic and opioid on the newborns. Adequate analgesia was obtained during labour with CSE technique, using ropivacaine combined with 50 and 100 microg morphine intrathecally. However cervical dilatation was faster and epidural local anaesthetic volume was lower in the group in which 100 microg morphine was used. Also considering the unchanged incidence of the side effects, 3 mg 0,2% ropivacaine + 100 microg morphine may be a useful combination for labour analgesia.
authors.affiliation: Department of Anaesthesiology and Reanimation, Kocaeli University, Medical Faculty, Kocaeli, Turkey. htutan@yahoo.com
authors.forename: Hamdiye Tutan
authors.initials: HT
authors.lastname: Culha
authors.forename: Dilek
authors.initials: D
authors.lastname: Ozdamar
authors.forename: Kamil
authors.initials: K
authors.lastname: Toker
authors.forename: Mine
authors.initials: M
authors.lastname: Solak
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage*; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007278:Injections, Spinal; D048949:Labor Pain / Q000188:drug therapy*; D007743:Labor, Obstetric; D009020:Morphine / Q000008:administration & dosage*; D010147:Pain Measurement; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D000077212:Ropivacaine; D016896:Treatment Outcome
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D000077212:Ropivacaine