Calcitonin-derived peptide carriers: mechanisms and application.
Among the family of the so-called cell-penetrating peptides (CPP) sequences derived from the native peptide hormone human calcitonin (hCT) have recently proven to translocate different bioactive molecules across cellular membranes. Herein, we give an extensive summary of the development of hCT-derived carrier peptides, beginning with the therapeutic nasal administration of full-length hCT. Hence, N-terminally truncated hCT fragments were investigated and subsequently optimised to extend their field of application. The latest generation of hCT-derived carrier peptides are highly effective, branched peptides. The current state of the art is reviewed concerning the structural requirements, mechanistic assumptions and metabolic features of these peptides as well as experiments proving their excellent carrier potential.
Rennert
Robert
R
Institute of Biochemistry, Faculty of Bioscience, Pharmacy and Psychology, Leipzig University, Brüderstr. 34, D-04103 Leipzig, Germany.
Neundorf
Ines
I
Beck-Sickinger
Annette G
AG
D000818:Animals; D002116:Calcitonin / Q000737:chemistry*; D002352:Carrier Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008954:Models, Biological; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000379:methods
D002352:Carrier Proteins; D010455:Peptides; D002116:Calcitonin