Preparation of cyanoacrylate nanoparticles using monosaccharides or disaccharides.
By using biomaterials, including monosaccharides and disaccharides, as polymeric stabilizing agents, the cyanoacrylate nanoparticles was prepared respectively, with particles diameter of approximately 200 nm or 300 nm. The new method was applied to load/encapsulate ampicillin (ABPC) and pDNA into nanoparticles. Loading efficiency of ABPC was increased compared to the existing method in which dextran is used as a stabilizer. The pDNA encapusulation rate was 68.7%, by using glucose.
Shirotake
Shoichi
S
Department of Pharmaco-Therapeutics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan. shirophd@med.yokohama-cu.ac.jp
Tomita
Yu'usuke
Y
Yoshizaki
Shinji
S
Okuda
Kenji
K
D000667:Ampicillin / Q000008:administration & dosage; D003487:Cyanoacrylates / Q000138:chemical synthesis*; D004247:DNA / Q000008:administration & dosage; D004187:Disaccharides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D009005:Monosaccharides / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size
D003487:Cyanoacrylates; D004187:Disaccharides; D004337:Drug Carriers; D009005:Monosaccharides; D000667:Ampicillin; D004247:DNA