Excess mortality and risk factors for mortality among a cohort of TB patients from rural south India.
OBJECTIVE
To estimate the excess general mortality among tuberculosis (TB) patients in a rural area (Tiruvallur) and identify risk factors for TB-related mortality.


METHODS
The study population consisted of all TB patients aged >or=15 years who were registered under the Revised National Tuberculosis Control Programme (RNTCP) during the years 2000 to 2003 at Velliyur TB unit (TU) in south India.


METHODS
This is a retrospective cohort study of 3405 patients treated under the DOTS strategy, followed up from the date of start of treatment till the date of interview (for the survivors) or the date of death (for those who died).


RESULTS
There were 2710 (79.6%) survivors and 695 (20.4%) deaths. The excess general mortalities for the cohort, expressed as standardised mortality ratio (SMR), was 4.2 (95%CI 3.9-4.5). High SMR values were obtained for patients belonging to the 15-44 years age group (12.1), patients on Category II regimen (9.3), treatment failures (9.1) and defaulters (7.8). The adjusted hazards ratios (aHR) were high for patients aged 45-59 years (1.9), >or=60 years (3.1) and with incomplete treatment due to default or failure (6.4).


CONCLUSIONS
TB is one of the main causes of mortality in the younger age group. Among TB patients, the major risk factors for mortality are old age (>or=45 years) and incomplete treatment.
Kolappan
C
C
Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India.
Subramani
R
R
Kumaraswami
V
V
Santha
T
T
Narayanan
P R
PR
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000995:Antitubercular Agents / Q000627:therapeutic use*; D023801:Directly Observed Therapy; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data*; D010349:Patient Compliance; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data*; D013997:Time Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*
D000995:Antitubercular Agents