Paradigms in isotope dilution mass spectrometry for elemental speciation analysis.
Isotope dilution mass spectrometry currently stands out as the method providing results with unchallenged precision and accuracy in elemental speciation. However, recent history of isotope dilution mass spectrometry has shown that the extent to which this primary ratio measurement method can deliver accurate results is still subject of active research. In this review, we will summarize the fundamental prerequisites behind isotope dilution mass spectrometry and discuss their practical limits of validity and effects on the accuracy of the obtained results. This review is not to be viewed as a critique of isotope dilution; rather its purpose is to highlight the lesser studied aspects that will ensure and elevate current supremacy of the results obtained from this method.
Meija
Juris
J
Institute for National Measurement Standards, National Research Council Canada, 1200 Montreal Road, Ottawa ON K1A 0R6, Canada. juris.meija@nrc.ca
Mester
Zoltán
Z
D007201:Indicator Dilution Techniques; D007554:Isotopes; D013058:Mass Spectrometry / Q000379:methods*; D011865:Radioisotope Dilution Technique; D015203:Reproducibility of Results
D007554:Isotopes