Antibacterial phenolic components from Eriocaulon buergerianum.
Five phenolic components, 1,3,6-trihydroxy-2,5,7-trimethoxyxanthone (1), 7,3'-dihydroxy-5,4',5'-trimethoxyisoflavone (2), toralactone-9-O-beta-D-glucopyranoside (3), patuletin-3-O-[2-O-E-feruloyl-beta-d-glucopyranosyl-(1-->6)-beta-d-glucopyranoside] (4), patuletin-3-O-[beta-d-glucopyranosyl-(1-->3)-2-O-E-caffeoyl-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside] (5), along with 19 known compounds were isolated from Eriocaulon buergerianum (Eriocaulaceae). Their structures were determined by spectroscopic and chemical methods. All 24 isolated compounds were tested against the pathogenic bacteria Staphylococcus aureus (ATCC 25923); as a result, 10 compounds were found to exhibit antibacterial activity with MICs ranging from 32 to 256 microg/ml.
Fang
Jing-Jing
JJ
Central Research Institute of Shanghai Pharmaceutical Group, Shanghai 201203, China.
Ye
Guan
G
Chen
Wen-Liang
WL
Zhao
Wei-Min
WM
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D039262:Eriocaulaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012015:Reference Standards; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D005960:Glucosides; D010636:Phenols