title: [Combined endolaryngeal videoendoscopic surgery and photodynamic treatment of patients with recurrent laryngeal and tracheal papillomatosis].
abstract: Two-stage combined treatment of chronic recurrent papillomatosis of the larynx and trachea has been designed and tested in P.A. Herzen Research Cancer Institute. Stage I of the treatment consisted in endolaryngeal videoendoscopic surgery with Nd:YAG-laser destruction, argon-plasma coagulation and electroresection of the papilloma; stage II - postoperative photodynamic therapy (PDT) to prevent recurrence. In 1995-2007 the treatment was given to 32 patients aged 10-66 years with recurrent papillomatosis of the airways with the disease history 5-58 years. In two thirds of the patients papillomatosis involved several parts of the larynx and trachea. Squamous cell papilloma was accompanied with dysplasia of the first-second degree in 10 (31%) patients, dysplasia of the third degree - in 4 (12,5%), cancer in situ - in 3 (9,4%) patients. Human papilloma virus (HPV) was detected by hybridization in situ in 96%. The course of the treatment resulted in a complete regression (CR) of papilloma in 25 of 32 (78%), partial regression in 7 patients. The recurrence-free interval averaged 32 months (maximal 7 years) in 14 of 25 patients with CR. HPV was eradicated in a group of patients with persistent clinical remission. A 6 to 19 month follow-up recorded papilloma recurrence in 11 patients. The recurrence-free period increased 2,5-fold. In patients with dysplasia of degree I-III and cancer in situ (n=17) CR of dysplasia and preinvasive cancer foci was achieved in 15 (88%) patients.
authors.forename: V V
authors.initials: VV
authors.lastname: Sokolov
authors.forename: A A
authors.initials: AA
authors.lastname: Gladyshev
authors.forename: L V
authors.initials: LV
authors.lastname: Telegina
authors.forename: E V
authors.initials: EV
authors.lastname: Filonenko
authors.forename: I G
authors.initials: IG
authors.lastname: Reshetov
authors.forename: A K
authors.initials: AK
authors.lastname: Golubtsov
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
authors.forename: T A
authors.initials: TA
authors.lastname: Belous
authors.forename: L E
authors.initials: LE
authors.lastname: Zavalishina
mesh_terms: D017115:Catheter Ablation / Q000379:methods; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007828:Laryngoscopy / Q000379:methods*; D017075:Laser Coagulation / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D010212:Papilloma / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D014134:Tracheal Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014741:Video Recording / Q000379:methods*