title: Comparison of outcomes with low-dose anti-thymocyte globulin, basiliximab or no induction therapy in pediatric kidney transplant recipients: a retrospective study.
abstract: It is unclear which induction therapy yields the best outcomes in pediatric kidney transplantation. Retrospective data of 88 children receiving a renal allograft between November 1996 and October 2003 were analyzed. Patients received ATGI (n = 12), BI (n = 29), or NAI (n = 47). The mean ATG dose was 5.1 +/- 2.1 mg/kg. At 12 months, graft survival rates were 91.7%, 100%, and 97.9% for ATGI, BI, and NAI groups, respectively. Acute rejection rates at 12 months were 0 (ATGI), 20.6% (BI), and 10.7% (NAI). The mean GFR for ATGI (42.4 +/- 25.9 mL/min) was lower than for BI (78.3 +/- 27.2 mL/min), and NAI (66 +/- 28.3 mL/min) at 12 months (p < 0.05). One ATGI patient developed CMV pneumonia but none developed post-transplant lymphoproliferative disorder. Although there was no renal allograft survival benefit with either ATGI or BI, relative to NAI, the absence of acute rejection and equivalent rates of viral infections in the higher-risk ATGI recipient group suggests that the treatment strategy is promising. A large prospective study is needed to better define the role of ATGI in pediatric kidney transplantation.
authors.affiliation: Transplantation Institute, Loma Linda University Medical Center, Loma Linda, California, USA. pbaron@llu.edu
authors.forename: Pedro W
authors.initials: PW
authors.lastname: Baron
authors.forename: Okechukwu N
authors.initials: ON
authors.lastname: Ojogho
authors.forename: Peter
authors.initials: P
authors.lastname: Yorgin
authors.forename: Shobha
authors.initials: S
authors.lastname: Sahney
authors.forename: Drew
authors.initials: D
authors.lastname: Cutler
authors.forename: Ramzi
authors.initials: R
authors.lastname: Ben-Youssef
authors.forename: Waheed
authors.initials: W
authors.lastname: Baqai
authors.forename: Jill
authors.initials: J
authors.lastname: Weissman
authors.forename: Edson
authors.initials: E
authors.lastname: Franco
authors.forename: Craig
authors.initials: C
authors.lastname: Zuppan
authors.forename: Waldo
authors.initials: W
authors.lastname: Concepcion
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000008:administration & dosage / Q000627:therapeutic use*; D000077552:Basiliximab; D002648:Child; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D000077552:Basiliximab