title: Path-length-resolved optical Doppler perfusion monitoring.
abstract: We report the first path-length-resolved perfusion measurements on human skin measured with a phase-modulated low-coherence Mach-Zehnder interferometer with spatially separated fibers for illumination and detection. Optical path lengths of Doppler shifted and unshifted light and path-length-dependent Doppler broadening of multiply scattered light from skin are measured from the Doppler broadened interference peaks appearing in the power spectrum. Perfusion and its variations during occlusion are measured in real time for a given optical path length, and the results are compared with the perfusion signal obtained with a conventional laser Doppler perfusion monitor.
authors.affiliation: University of Twente, Institute for Biomedical Technology BMTI, Biophysical Engineering Group, Faculty of Science and Technology, P.O. Box 217, 7500 AE Enschede, The Netherlands. b.varghese@utwente.nl
authors.forename: Babu
authors.initials: B
authors.lastname: Varghese
authors.forename: Vinayakrishnan
authors.initials: V
authors.lastname: Rajan
authors.forename: Ton G
authors.initials: TG
authors.lastname: Van Leeuwen
authors.forename: Wiendelt
authors.initials: W
authors.lastname: Steenbergen
mesh_terms: D004301:Doppler Effect; D005336:Fiber Optic Technology; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods; D012867:Skin / Q000098:blood supply*