Is experimental endotoxaemia in humans suitable for simulating antibiotic pharmacokinetics in sepsis and septic shock? A pilot study using the model compound fosfomycin.
Sauermann
Robert
R
Mayer-Helm
Bernhard X
BX
Petsch
Martina
M
Popovic
Martin
M
Thallinger
Christiane
C
Joukhadar
Christian
C
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019446:Endotoxemia; D005578:Fosfomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D010865:Pilot Projects; D018805:Sepsis / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D005578:Fosfomycin