Release study of diclofenac from new carbomer gels.
Carbopol gels were prepared using a traditional polymer with mucoadhesive properties (974P). A new Carbomer derivative Ultrez 21 was also evaluated. Mineral oil, as occlusive ingredient, glycerol as humectant and ethanol were included in all the compositions. The feasibility of preparing these formulations with or without a bioadhesive polymer (Polycarbophil AA-1) and a second oil phase with enhancer activity (Miglyol 840) was evaluated. Further characterization including physical stability during a year was carried out. In vitro release behaviour of diclofenac sodium in Franz diffusion cell was evaluated with some selected formulations using an ethanol-water (50% w/w) solution as receptor medium. Addition of Polycarbophil AA-1 increased formulation viscosity and decreased drug release. These types of topical dosage forms could give sustained delivery of drug onto the skin, could tolerate the incorporation of an enhancer, a humectant and an occlusive phase, so they are interesting promises to improve skin absorption of nonsteroidal anti-inflammatory drugs and to prevent side effects associated.
Bregni
Carlos
C
Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina. cbregni@ciudad.com.ar
Chiappetta
Diego
D
Faiden
Natalia
N
Carlucci
Adriana
A
García
Roberto
R
Pasquali
Ricardoc
R
D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D004075:Diglycerides / Q000737:chemistry; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D005782:Gels; D006863:Hydrogen-Ion Concentration; D014783:Viscosity
D000179:Acrylates; D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004075:Diglycerides; D005782:Gels; C479038:carbomer; C117167:carbopol 974P NF; D004008:Diclofenac; C079597:miglyol 840