Aquagenic wrinkling of the palms in a cystic fibrosis carrier.
A 16-year-old girl presented with a 3-year history of painful swelling and wrinkling of her palms on exposure to water. Physical examination, after less than 2 min of immersion, showed thickening and exaggerated wrinkling of the palms giving a whitish pebbly appearance. Aquagenic wrinkling of the palms was diagnosed. The patient was tested for the common cystic fibrosis mutations, and was found to be heterozygous for the arg117His cystic fibrosis mutation. Her sweat test was normal.
Gild
Rochelle
R
Royal Perth Hospital, Perth, WA, Australia. osroch@graduate.uwa.edu.au
Clay
Christopher D
CD
D000293:Adolescent; D003550:Cystic Fibrosis / Q000150:complications* / Q000235:genetics; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000209:etiology*; D006579:Heterozygote; D006801:Humans; D007101:Immersion; D009154:Mutation; D010146:Pain / Q000209:etiology; D012867:Skin / Q000473:pathology*; D014867:Water / Q000009:adverse effects*
D014867:Water