[Numerical density of eosiophilic leukocytes in skin basal and squamous cell carcinomas].
The autors examined the presence and determined numerical density of eosinophilic leukocytes in tumor's stormal and host reaction in twenty routine preparated skin biopsies of basal and squamos cell carcinomas. The presence of eosiophilic leukocytes in squamous cell carcinomas, in stormal and adjacent tumor infiltrate were confirmed, so as the absance on the same localizations in basal cell carcinomas were found. Eosinophilic leukocytes were of caracteristic morphological appereance, smaller of blood and bone marrow eosinophils - the average radius were 9,6 microm, with high level of degranulation, very variable in number (from 1054 to 23560 in mm3) and in close relation with plasma cells, mast cells and lymphocytes. In conclusion, these results may indicate and clear up presence of eosinophils by antigen properties of tumor cells, by activation of humoral immunity and consecutive phagogytosis of antigen-antibody complexes by eosinophils, but specially by their novel lytical effects on epithelial tumor cells in texture of cellular cytotoxic response. Beside these favorable effects of eosinophils, their granular enzymes activated and released during degranulation paradoxlly make spreading of tumor process possible and they reduce barrier role of dermal collagen.
Rancić
G
G
Petrović
S
S
Stanojević
M
M
Petrović
A
A
Trajkovski
S
S
D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002452:Cell Count; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*