[Relation of tumor associated macrophages and mast cells of tumor interstitial and angiogenesis in non-small cell lung cancer].
OBJECTIVE
To detect tumor microvessel count (MVC), tumor associated macrophage (TAM) and Mast cell (MC) counts, and to explore their correlation and the clinical significance in non-small cell lung cancer (NSCLC).


METHODS
Immunohistochemical staining (ABC method) was used to measure MVC and TAM and MC counts in 40 cases of NSCLC tissues and 10 cases of normal pulmonary tissues as contrast.


RESULTS
The counts of microvessel, TAMs, and MCs in the NSCLC tissues were apparently higher than those of the normal tissues, and these counts increased with the development of T stage and clinical stage, metastasis of the tumor, and the reduction of the patient survival time. The positive correlation was showed among the counts of microvessel, TAMs, and MCs.


CONCLUSIONS
Tumor interstitial infiltrating inflammatory cells, TAMs and MCs can cooperatively promote the tumor angiogenesis,which associates with the development, invasion, metastasis and prognosis of NSCLC.
Zou
Wen
W
Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China. zouwen29w@126.com
Hu
Tie-hui
TH
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000098:blood supply* / Q000473:pathology; D008264:Macrophages / Q000166:cytology*; D008297:Male; D008407:Mast Cells / Q000166:cytology*; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011379:Prognosis