Systemic lupus erythematosus and "lupus dyslipoproteinemia".
A growing body of evidences reinforces the close link between systemic lupus erythematosus (SLE) and atherosclerosis which is due to traditional and nontraditional risk factors for cardiovascular diseases. It is now recognized that SLE has a particular pattern of dyslipoproteinemia characterized by low HDL levels and increased triglycerides, which is aggravated by flares. Multiple mechanisms can induce an altered lipoprotein metabolism in SLE such as cytokines produced during systemic inflammation, autoantibodies and therapy.
de Carvalho
Jozélio Freire
JF
Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo e Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. reumato@usp.br
Bonfá
Eloísa
E
Borba
Eduardo Ferreira
EF
D001323:Autoantibodies / Q000097:blood; D050171:Dyslipidemias / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000503:physiopathology*
D001323:Autoantibodies