title: Olive oil increases the hepatic triacylglycerol content in mice by a distinct influence on the synthesis and oxidation of fatty acids.
abstract: Diet supplementation with olive oil exerts beneficial effects on an organism, even if an increase in the level of hepatic lipids has been concomitantly observed. This study was therefore designed to investigate whether the stimulation of lipogenesis was responsible for the olive oil-induced hepatic fat accumulation. In mice fed for 8 weeks with an olive oil-enriched diet, an increase of about 2.6 fold in the level of liver triglycerides was found in comparison to animals fed with a corn oil-containing diet. Despite that, no increase in the activities of cytosolic lipogenic enzymes or of the mitochondrial tricarboxylate carrier was found; on the contrary, a decrease in the activity of carnitine palmitoyltransferase I was observed. This impairment of fatty acid oxidation, which was not apparent in corn oil-fed animals, may have had a role in the increase of hepatic lipid content found in the olive oil-fed mice.
authors.affiliation: Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce-Monteroni, Lecce, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ferramosca
authors.forename: Viviana
authors.initials: V
authors.lastname: Savy
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Zara
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003314:Corn Oil / Q000494:pharmacology; D019587:Dietary Supplements; D002149:Energy Intake; D005227:Fatty Acids / Q000096:biosynthesis / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000069463:Olive Oil; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D014280:Triglycerides; D003314:Corn Oil; D002784:Cholesterol