Adeno-associated viral vectors and the retina.
Recombinant adeno-associated viral vectors have slowly been moving to the forefront of gene therapy experiments. Given the non-pathogenic nature, low immunogenicity, ease of delivery, persistence, and targeting possibilities of rAAV, it is poised to become a major player in retinal gene therapy.
Alexander
John J
JJ
Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610-0266, USA. zander@ufl.edu
Hauswirth
William W
WW
D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D012160:Retina / Q000378:metabolism*; D012164:Retinal Diseases / Q000628:therapy*