title: Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.
abstract: Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight (p < 0.008) and blood glucose levels (p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice (p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México. perezyy@yahoo.com
authors.forename: Yolanda Y
authors.initials: YY
authors.lastname: Pérez
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez-Ferrer
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamilpa
authors.forename: Marcelino
authors.initials: M
authors.lastname: Hernández-Valencia
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Alarcón-Aguilar
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: Rubén
authors.initials: R
authors.lastname: Román-Ramos
mesh_terms: D000504:Aloe; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005419:Flavonoids / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology*; D000077205:Pioglitazone; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols; D011897:Random Allocation; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D045162:Thiazolidinediones; D000077205:Pioglitazone