title: Mouse models for understanding the growth hormone insulin-like growth factor-I axis.
abstract: BACKGROUND
  Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass.
  
  
  CONCLUSIONS
  Mouse models continue to deepen our understanding of IGF-I signaling and the role of IGF-I in determining marrow stromal cell fate.
authors.affiliation: Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Me. 04401, USA. crosen@maine.maine.edu
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Rosen
mesh_terms: D050156:Adipogenesis / Q000502:physiology; D000273:Adipose Tissue / Q000502:physiology; D000483:Alleles; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009154:Mutation; D010012:Osteogenesis / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D015398:Signal Transduction; D017154:Stromal Cells / Q000502:physiology
chemical_list: D047495:PPAR gamma; D007334:Insulin-Like Growth Factor I