Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.
In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.
Wirths
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Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany. owirths@uni-goettingen.de
Bayer
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TA
D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000209:etiology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D016875:tau Proteins