Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats.
Perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. This study examined the effects of perinatal PCP treatment on behaviour of adult rats in holeboard, elevated plus maze, social interaction and forced swim tests. PCP-treated rats displayed hyperactivity in the holeboard and forced swim tests. These persistent behavioural changes are relevant to the study of psychiatric disorders such as schizophrenia.
du Bois
Teresa Marie
TM
Schizophrenia Research Institute (SRI), Sydney, Australia. tmdb66@uow.edu.au
Huang
Xu-Feng
XF
Deng
Chao
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D007398:Interpersonal Relations; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D010622:Phencyclidine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming
D010622:Phencyclidine