Evaluation of the antigenic relationships among canine parvovirus type 2 variants.
The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, -2b, and -2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, -2b, and -2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2, CPV-2a, and CPV-2b. However, animals immunized with CPV-2c exhibited higher SN titers to CPV-2b than to the homologous virus CPV-2c. The observed antigenic differences might drive selection of CPV strains by generating differential immune pressure in the canine population, which raises concerns about vaccine efficacy.
Cavalli
Alessandra
A
Department of Animal Health and Well-Being, University of Bari, Valenzano, Bari, Italy. a.cavalli@veterinaria.uniba.it
Martella
Vito
V
Desario
Costantina
C
Camero
Michele
M
Bellacicco
Anna Lucia
AL
De Palo
Pasquale
P
Decaro
Nicola
N
Elia
Gabriella
G
Buonavoglia
Canio
C
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology*; D004283:Dog Diseases / Q000276:immunology* / Q000821:virology; D004285:Dogs; D006385:Hemagglutination Inhibition Tests; D007114:Immunization; D009500:Neutralization Tests; D010322:Parvoviridae Infections / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D011817:Rabbits
D000914:Antibodies, Viral; D000956:Antigens, Viral