Capsule acetylation does not impair recognition of serogroup C, W-135 and Y meningococci by human dendritic cells.
The capsule polysaccharide of several Neisseria meningitidis serogroups can be modified by O-acetylation in vivo. As capsule expression is a major determinant of the interaction between N. meningitidis and human dendritic cells (DCs), the influence of the capsule polysaccharide acetylation status on activation of DCs was investigated. For serogroup C, W-135 and Y, mutations resulting in a lack of capsule acetylation did not interfere with recognition and phagocytosis of N. meningitidis, induction of DC maturation or triggering of cytokine release. Therefore, acetylation of the meningococcal capsule does not modify the activation of dendritic cells by this pathogen.
Villwock
Andrea
A
Institute of Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2/E1, D-97080 Würzburg, Germany.
Schmitt
Corinna
C
Frosch
Matthias
M
Kurzai
Oliver
O
D000107:Acetylation; D016667:Bacterial Capsules / Q000276:immunology* / Q000378:metabolism*; D015169:Colony Count, Microbial; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D009345:Neisseria meningitidis / Q000276:immunology*; D010587:Phagocytosis
D016207:Cytokines