title: [Changes of prethrombotic state indexes in patients with malignant cancer].
abstract: OBJECTIVE
  To study the changes and significance of prethrombotic state indexes in patients with malignant cancer.
  
  
  METHODS
  The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer.
  
  
  RESULTS
  The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P<0.05); the level of t-PA in the tumor group decreased compared with that in the control group (P<0.05). APTT and PT were significantly shortened in the tumor group (P<0.05). There was no significant changes of TT in 2 groups (P>0.05).
  
  
  CONCLUSIONS
  The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.
authors.affiliation: Department of Immunology, Xinjiang Medical University, Xinjiang Autonomous Region, Urumqi 830054, China.
authors.forename: Shajidan
authors.initials: S
authors.lastname: Abudoureyimu
authors.forename: Hong-liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Renaguli
authors.initials: R
authors.lastname: Aizezi
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D019007:P-Selectin / Q000378:metabolism; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011517:Prothrombin Time; D013918:Thrombin Time; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D019332:Endothelin-1; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator