title: [Changes of plasma CD40L and PAPP-A in patients with acute coronary syndrome after the PCI operation].
abstract: OBJECTIVE
  To observe the changes and significance of plasma CD40L and pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI) operation.
  
  
  METHODS
  According to the occurrence of primary heart events or restenosis 6 months after the PCI, 68 patients were divided into the ACS group and the stable angina pectoris (SAP) group. Plasma CD40L and PAPP-A after the PCI operation were measured and compared. Thirty-six patients underwent repeated angiography after the PCI. Their baseline and follow up angiograms were compared by quantitative coronary angiography to assess the incidence of restenosis.
  
  
  RESULTS
  CD40L and PAPP-A after the PCI operation were higher in the ACS group than that in the SAP group.The group having primary heart events within 6 months had higher level of PAPP-A after the PCI. The group having restenosis 6 months had higher level of PAPP-A after the PCI. The change of later loss index of coronary artery lumen diameter was correlated with PAPP-A level after the PCI.
  
  
  CONCLUSIONS
  CD40L and PAPP-A were higher in the ACS group, indicating the possible mechanism by which CD40L facilitates the plaque rupture via up-regulating the PAPP-A expression.Plasma PAPP-A level after the PCI possibly for cases the occurrence of primary heart events or restenosis within 6 months.
authors.affiliation: Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. lixp0711@126.com
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: Li
authors.forename: Sheng-hua
authors.initials: SH
authors.lastname: Zhou
authors.forename: Jian-zhun
authors.initials: JZ
authors.lastname: Tang
authors.forename: Qi-ming
authors.initials: QM
authors.lastname: Liu
authors.forename: Zhen-fei
authors.initials: ZF
authors.lastname: Fang
authors.forename: Xin-qun
authors.initials: XQ
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Xiang-qian
authors.initials: XQ
authors.lastname: Shen
authors.forename: Shu-shan
authors.initials: SS
authors.lastname: Qi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011184:Postoperative Period; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*
chemical_list: D023201:CD40 Ligand; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human