title: Idiopathic short stature: definition, epidemiology, and diagnostic evaluation.
abstract: Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, and according to pubertal delay. It should be differentiated from dysmorphic syndromes, skeletal dysplasias, short stature secondary to a small birth size (small for gestational age, SGA), and systemic and endocrine diseases. ISS is the diagnostic group that remains after excluding known conditions in short children.
authors.affiliation: Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. j.m.wit@lumc.nl
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: P E
authors.initials: PE
authors.lastname: Clayton
authors.forename: A D
authors.initials: AD
authors.lastname: Rogol
authors.forename: M O
authors.initials: MO
authors.lastname: Savage
authors.forename: P H
authors.initials: PH
authors.lastname: Saenger
authors.forename: P
authors.initials: P
authors.lastname: Cohen
mesh_terms: D001827:Body Height / Q000502:physiology; D003940:Diagnostic Techniques, Endocrine; D006130:Growth Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006801:Humans; D025202:Molecular Diagnostic Techniques