Risk factors for surgical-site infections in head and neck cancer surgery.
OBJECTIVE
The aim of this study was to identify risk factors for surgical-site infections (SSIs) in patients with head and neck cancer submitted to major clean-contaminated surgery.


METHODS
This is a prospective study conducted in a tertiary cancer center hospital.


METHODS
This study includes 258 patients submitted to a major clean-contaminated head and neck oncologic surgery.


RESULTS
The overall SSI rate was 38.8%. The univariate analysis showed the following significant risk factors: race, tobacco consumption, clinical stage, comorbidities, time duration of the surgical procedure, and flap reconstruction. The final model by logistic regression identified the following independent predictors for SSI: tobacco consumption (odds ratio [OR] = 2.96), presence of metastatic lymph nodes (OR = 2.05), flap reconstruction (OR = 2.20), and antimicrobial prophylaxis exceeding 48 hours (OR=1.89).


CONCLUSIONS
The high-risk patients for SSI in head and neck oncologic surgery were those with cancer at advanced stages, those who were smokers, those presenting comorbidities, those who needed major reconstruction of the surgical wound, or those who were submitted to inadequate antibiotic prophylaxis.
Lotfi
Carlos Jorge
CJ
Infectious Diseases Service, Hospital do Câncer A.C.Camargo, São Paulo, Brazil. scih@hcsancer.org.br
Cavalcanti
Rita de Cássia
Rde C
Costa e Silva
Adriana Maria
AM
Latorre
Maria do Rosário Dias de Oliveira
Mdo R
Ribeiro
Karina de Cássia Braga
Kde C
Carvalho
André Lopes
AL
Kowalski
Luiz Paulo
LP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control
D000900:Anti-Bacterial Agents