Antimicrobial potential of Glycyrrhiza glabra roots.
The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H(37)Ra and H(37)Rv strains at 29.16 microg/mL concentration. It exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our results indicate potential use of licorice as antitubercular agent through systemic experiments and sophisticated anti-TB assay.
Gupta
Vivek K
VK
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.
Fatima
Atiya
A
Faridi
Uzma
U
Negi
Arvind S
AS
Shanker
Karuna
K
Kumar
J K
JK
Rahuja
Neha
N
Luqman
Suaib
S
Sisodia
Brijesh S
BS
Saikia
Dharmendra
D
Darokar
M P
MP
Khanuja
Suman P S
SP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010936:Plant Extracts