title: A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity.
authors.affiliation: Department of Ophthalmology, Columbia University, New York, NY 10032, USA. jrs88@columbia.edu
authors.forename: Janet R
authors.initials: JR
authors.lastname: Sparrow
authors.forename: So Ra
authors.initials: SR
authors.lastname: Kim
authors.forename: Ana M
authors.initials: AM
authors.lastname: Cuervo
authors.forename: Urmi
authors.initials: U
authors.lastname: Bandhyopadhyayand
mesh_terms: D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006868:Hydrolysis; D008062:Lipofuscin / Q000737:chemistry / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010739:Phospholipase D / Q000378:metabolism*; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D011726:Pyridinium Compounds / Q000032:analysis; D019572:Retinal Neoplasms / Q000473:pathology; D012172:Retinaldehyde / Q000031:analogs & derivatives / Q000737:chemistry; D012176:Retinoids / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: C112040:A2-E (N-retinylidene-N-retinylethanolamine); D008062:Lipofuscin; D010714:Phosphatidylethanolamines; D011726:Pyridinium Compounds; D012176:Retinoids; C525876:retinal dimer; C007510:1,2-dipalmitoyl-3-phosphatidylethanolamine; C483858:phosphatidylethanolamine; D010739:Phospholipase D; D012172:Retinaldehyde