Primary hepatic clear cell myomelanocytic tumor. Case report and review of the literature.
A case of hepatic clear cell myomelanocytic tumor in a 31-year-old woman presenting clinically with abdominal pain is reported. Histopathologic examination showed a lesion characterized by a population of large epithelioid cells with clear or eosinophilic granular cytoplasm, rich in glycogen. Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A and muscle-specific actin, but negative for epithelial markers, desmin, S-100 protein, and neuroendocrine markers. Ultrastructurally, the tumor cells had abundant glycogen, well-developed rough endoplasmic reticulum, microtubules and aberrant melanosomes. Clinical and pathologic features with a brief review of the relevant literature for hepatic CCMMT as a variant of perivascular epithelioid cell tumor (PEComa) are discussed.
Larbcharoensub
Noppadol
N
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Noppadol_1@hotmail.com
Karnsombut
Patcharee
P
Jatchavala
Janjira
J
Wasutit
Yodying
Y
Nitiyanant
Prawat
P
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D042882:Gallstones / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D018235:Smooth Muscle Tumor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor