Cyclo-glycyl-glutamine inhibits ethanol intake in P and Sprague-Dawley rats.
Peptide inhibitors of ethanol consumption have shown promise. The purpose of this study was to test the cyclized form of the opioid-derived dipeptide, glycyl-L-glutamine to reduce ethanol consumption after either peripheral injections or site-specific injections into the nucleus accumbens (NAC) of high drinking and low drinking rats. Following I.P. cyclo-glycyl-glutamine (c-GQ), the data show a mean decrease in ethanol intake of 34.4% in P rats, and 39.4% in Sprague-Dawley rats at doses between 5 and 25mg/kg. The data show that peripherally administered c-GQ is effective in reducing ethanol consumption in both high (P) and low (SD) drinking strains of rats and suggests a therapeutic potential.
Resch
Garth E
GE
Division of Molecular Biology and Biochemistry, University of Missouri-Kansas City, Kansas City, MO 64110-2792, USA. reschg@umkc.edu
Simpson
C Wayne
CW
D000428:Alcohol Drinking / Q000517:prevention & control*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D008954:Models, Biological; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004151:Dipeptides; D010456:Peptides, Cyclic; C470706:cyclo(glycyl-glutamine); D000431:Ethanol