[Carbohydrate metabolism and aging--controversy of etiopathogenesis and pathophysiology. Part I. Changes of insulin sensitivity].
Insulin resistance is one of the reasons of increasing carbohydrate metabolism disturbances with aging. Mechanisms of these changes had been partially elucidated. Decreasing of physical activity with increasing of total and abdominal fat are especially important pathogenetic mechanisms. Changes in glucose transporter 4 (GLUT-4) level in skeletal muscles and serum level of insulin like growth factor 1 (IGF-1) could be mechanisms independent of fat tissue. Other mechanisms which could be associated with insulin resistance in aging are related to leptin and adiponectin serum level or changes in mitochondrial energy metabolism and level of advanced glucose end products in diet.
Sokup
Alina
A
Katedry i Kliniki Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu. alinasokup@o2.pl
Swiatkowski
Maciej
M
D052242:Adiponectin / Q000097:blood; D000375:Aging / Q000378:metabolism*; D050260:Carbohydrate Metabolism / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D018482:Muscle, Skeletal / Q000378:metabolism
D052242:Adiponectin; D051275:Glucose Transporter Type 4; D007328:Insulin; D020738:Leptin; D007334:Insulin-Like Growth Factor I