title: Heparin-induced thrombocytopenia complicating hemodialysis.
abstract: Hemodialysis complicated by heparin-induced thrombocytopenia (HIT) is a rare event requiring anticoagulation with direct-thrombin inhibitors. Contaminant calcific uremic arteriolopathy (calciphylaxis) further complicates this situation due to the possibility that warfarin anticoagulation may exacerbate skin necrosis. The authors report a patient with renal failure and calciphylaxis who developed HIT after starting hemodialysis. She was successfully treated with Argatroban.
authors.affiliation: Don Monti Division of Medical Oncology/Division of Hematology, North Shore University Hospital, New York University School of Medicine, New York 11042, USA. m_barginear@hotmail.com
authors.forename: M F
authors.initials: MF
authors.lastname: Barginear
authors.forename: L
authors.initials: L
authors.lastname: Donahue
authors.forename: S L
authors.initials: SL
authors.lastname: Allen
authors.forename: D R
authors.initials: DR
authors.lastname: Budman
authors.forename: T
authors.initials: T
authors.lastname: Bradley
authors.forename: M
authors.initials: M
authors.lastname: Bhaskaran
authors.forename: I
authors.initials: I
authors.lastname: Shapira
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D002115:Calciphylaxis / Q000473:pathology*; D004340:Drug Contamination; D005260:Female; D006493:Heparin; D006801:Humans; D009336:Necrosis / Q000139:chemically induced; D010875:Pipecolic Acids / Q000627:therapeutic use; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications*; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D014859:Warfarin; D006493:Heparin; D001120:Arginine; C031942:argatroban