title: Synthesis and pharmacological activities of 7-azaindole derivatives.
abstract: As a part of our program to discover novel analogues of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine) having useful biological activities, some derivatives have been synthesized and evaluated for their analgesic and hypotensive activity. Compounds evaluated by thermal stimuli (tail immersion method) at the dose of 50 mg/kg of body weight revealed significant analgesic activity. Pethidine was used as reference drug. Same compounds tested at the dose of 75 mg/kg of body weight showed toxicity. Compounds tested for their effect on blood pressure in normotensive rat produced slight fall in blood pressure.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan. noshin_mushtaq@yahoo.com
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.forename: Z S
authors.initials: ZS
authors.lastname: Saify
authors.forename: Fozia
authors.initials: F
authors.lastname: Noor
authors.forename: Shamoona
authors.initials: S
authors.lastname: Takween
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000959:Antihypertensive Agents; D001372:Aza Compounds; D007211:Indoles