title: Primary signet-ring cell carcinoma of the prostate.
abstract: We report a rare case of primary signet-ring cell carcinoma of the prostate in an advanced stage. A 62-year-old man with serum level of prostate-specific antigen at 364.70 ng/ml was diagnosed as having cT4N1M1c prostatic signet-ring cell carcinoma of Gleason score 5 + 4 = 9. Immunohistochemical examination demonstrated cytoplasmic immunoreactivity to prostate-specific antigen in signet-ring cancer cells. The intracytoplasmic vacuoles in the signet-ring cells showed mucin production with a positive staining with periodic acid-Schiff. Although the patient received hormonal therapy, the disease progressed and lead to death 15 months after the diagnosis. The clinical and immunohistochemical characteristics of this malignancy are also reviewed.
authors.affiliation: Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Gaku
authors.initials: G
authors.lastname: Arai
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ishimaru
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ito
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy