title: Prognostic factors in monoclonal gammopathy of undetermined significance.
abstract: A retrospective evaluation of 285 patients with monoclonal gammopathy of undetermined significance was performed to identify variables associated with progression, actuarial progression free survival (PFS) and overall survival (OS). Three variables, level of uninvolved immunoglobulins (HR 4.98, CI95% 2 -12.4, p=0.0006), monoclonal protein concentration (HR 4.04, CI95% 1.6-10.34, p=0.004), and erythrosedimentation rate (HR 3.94, CI95% 1.33-11.6, p=0.01), showed independent prognostic significance. With a median follow-up of 66 months (range 6-378), PFS and OS at 10 years were 89% and 91% respectively.
authors.forename: Federico
authors.initials: F
authors.lastname: Sackmann
authors.forename: Miguel Arturo
authors.initials: MA
authors.lastname: Pavlovsky
authors.forename: Claudia
authors.initials: C
authors.lastname: Corrado
authors.forename: Marco
authors.initials: M
authors.lastname: Pizzolato
authors.forename: Mariel
authors.initials: M
authors.lastname: Alejandre
authors.forename: Santiago
authors.initials: S
authors.lastname: Pavlovsky
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins