Ti-catalyzed reformatsky-type coupling between alpha-halo ketones and aldehydes.
We describe the first Ti-catalyzed Reformatsky-type coupling between alpha-halo ketones and aldehydes. The reaction affords beta-hydroxy ketones under mild, neutral conditions compatible with ketones and other electrophiles. The catalytic cycle possibly proceeds via bis(cyclopentadienyl)titanium enolates.
Estévez
Rosa E
RE
Department of Organic Chemistry, University of Granada, Faculty of Sciences, Campus Fuentenueva s/n, E-18071 Granada, Spain.
Paradas
Miguel
M
Millan
Alba
A
Jiménez
Tania
T
Robles
Rafael
R
Cuerva
Juan M
JM
Oltra
J Enrique
JE