[Analysis of twelve cases of angiofollicular lymph node hyperplasia with literature review].
OBJECTIVE
Angiofollicular lymph node hyperplasia (AFH) is a rare lymphoproliferative disorder disease. This study was to investigate the clinical characteristics, treatment and prognosis of AFH.


METHODS
Clinical data of 12 AFH patients, admitted in Guangdong Provincial People's Hospital from Oct. 1989 to Dec. 2006, were analyzed. All cases were diagnosed by lymph node biopsy.


RESULTS
Of the 12 cases of AFH, 9 were unicentric disease characterized by localized lymph node enlargement, and 3 were multicentric disease characterized by multiple lymph node enlargement accompanied by systemic symptoms. The 9 patients with unicentric disease received tumor resection and were followed up for a median of 30 months; 8 responded well to surgical resection and 1 was lost. Of the 3 patients with multicentric disease, 2 were treated with chemotherapy and achieved partial remission, 1 received no antitumor therapy and died of multi-organ failure in 21 months.


CONCLUSIONS
Unicentric AFH can be cured by surgery alone and have a good prognosis after operation; multicentric AFH needs aggressive and systemic chemotherapy.
Dong
Qiu-Mei
QM
Department of Medical Oncology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, PR China. dqmzhang@163.com
He
You-Jian
YJ
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005871:Castleman Disease / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003520:Cyclophosphamide / Q000627:therapeutic use; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use; D055815:Young Adult
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone