title: Functional recovery of rabbit maxillary sinus mucosa in two different experimental injury models.
abstract: OBJECTIVE
  Ciliary wave disorder (CWD) is essential for effective mucociliary transport. The purpose of this study was to investigate morphologic and functional restoration in recovered sinus mucosa after 12 weeks of experimentally induced rhinosinusitis and regenerated sinus mucosa after mechanical injury.
  
  
  METHODS
  Prospective study with animal models.
  
  
  METHODS
  Ten New Zealand white rabbits weighing between 2.5 and 3 kg were used for this experiment. In the recovered mucosa group (n = 5), the natural ostium of the maxillary sinus was closed with a synthetic sponge and removed 2 weeks later. In the regenerated sinus mucosa group (n = 5), maxillary sinus mucosa was stripped off through the anterior wall. Left sinus mucosae were used as controls. Twelve weeks postoperatively, ciliary beat frequency (CBF) and CWD were measured using an image analysis system. Morphologic changes in cilia were also observed using a scanning electron microscope (SEM).
  
  
  RESULTS
  The average CBFs in control, recovered, and regenerated mucosa were 13.21 +/- 3.66 Hz, 13.20 +/- 3.53 Hz, and 14.16 +/- 3.87 Hz, respectively. The average CWDs in these groups were 8.46 +/- 4.4, 21.04 +/- 14.73, and 24.43 +/- 19.2, respectively. SEM showed that loss of cilia and irregularities of ciliary arrangements were prominent in regenerated sinus mucosa.
  
  
  CONCLUSIONS
  Although 12 weeks is enough for morphologic regeneration of the ciliated epithelium after experimental sinusitis in rabbit maxillary sinuses, it does not appear long enough for full functional recovery. Restoration of CBFs does not equate to concurrent CWD restoration.
authors.affiliation: Department of Otorhinolaryngology, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Kim
authors.forename: Chul Hee
authors.initials: CH
authors.lastname: Lee
authors.forename: Tae-Bin
authors.initials: TB
authors.lastname: Won
authors.forename: Si Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Jeong-Whun
authors.initials: JW
authors.lastname: Kim
authors.forename: Chae-Seo
authors.initials: CS
authors.lastname: Rhee
authors.forename: Yang-Gi
authors.initials: YG
authors.lastname: Min
mesh_terms: D000818:Animals; D002925:Ciliary Motility Disorders / Q000534:rehabilitation*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008443:Maxillary Sinus / Q000293:injuries*; D011817:Rabbits; D020127:Recovery of Function; D020545:Respiratory Mucosa / Q000293:injuries*; D012220:Rhinitis / Q000534:rehabilitation*; D012852:Sinusitis / Q000534:rehabilitation*