title: Basal follicle-stimulating hormone as a predictor of fetal aneuploidy.
abstract: OBJECTIVE
  To determine whether an elevated basal FSH concentration is an independent predictor of fetal aneuploidy, as measured in spontaneous abortions (SAB).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Academic reproductive endocrinology and infertility center.
  
  
  METHODS
  All women with karyotypes of chorionic villi isolated from first trimester spontaneous miscarriages at the time of dilation and curettage from 1999 to 2006. The highest basal serum FSH level in the year preceding dilation and curettage was recorded.
  
  
  METHODS
  Monitoring of early pregnancy.
  
  
  METHODS
  Fetal karyotype.
  
  
  RESULTS
  A total of 177 spontaneous miscarriages with karyotypes (70 euploid and 107 aneuploid) were identified, of which 53% were conceived by IVF. The aneuploid cohort consisted of trisomic (87%), teraploid (9.3%), and monosomic (3.7%) gestations. Using logistic regression analysis, basal FSH was not found to be independently predictive of an aneuploid gestation in our data set.
  
  
  CONCLUSIONS
  Our data do not support the hypothesis that an elevated basal FSH concentration is associated with an increase in fetal aneuploidy. Our findings suggest that the association between diminished ovarian reserve and SAB may result from nonkaryotypic factors.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA.
authors.forename: Jamie A M
authors.initials: JA
authors.lastname: Massie
authors.forename: Richard O
authors.initials: RO
authors.lastname: Burney
authors.forename: Amin A
authors.initials: AA
authors.lastname: Milki
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Westphal
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Lathi
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood*; D006801:Humans; D007621:Karyotyping; D016015:Logistic Models; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human