title: Distortion product otoacoustic emissions for assessment of intracranial hypertension at extreme altitude?
abstract: The levels of distortion product otoacoustic emissions (DPOAEs) change at frequencies between 0.75 and 1.5 kHz along with intracranial pressure (ICP) and DPOAEs are suggested for monitoring ICP changes. Elevated ICP plays a major role in high-altitude disease, but direct measurement is unlikely to be feasible at high altitudes. The aim of the presented study was to measure DPOAEs at extreme altitudes in order to determine whether information about elevated ICP can be obtained. Data are presented from DPOAE measurements at the frequencies 1, 1.5, 2, 3 and 4 kHz in 13 climbers during an ascent to Gasherbrum II (8,035 m) up to an altitude of 7,400 m. Valid DPOAE measurements could be obtained in all climbers. DPOAE levels exhibited great variability concerning both the affected frequency range and the change. As expected due to elevated ICP, DPOAE levels decreased in some of the climbers at 1 kHz. However, an even more pronounced decline of DPOAE levels was observed at 3 and 4 kHz, which cannot be explained by intracranial hypertension. Possible other reasons for DPOAE level changes at extreme altitude are hypoxia, increased serum osmolarity and unbalanced middle ear pressure. Only one climber developed severe acute mountain sickness with clinical signs of intracranial hypertension. The most pronounced decline of DPOAEs at 1 kHz was seen on that occasion, which suggests a possible use of DPOAEs for detection of intracranial hypertension and early detection of high-altitude cerebral edema.
authors.affiliation: Department for Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, Marchioninistrasse 15, 81377, Munich, Germany. bernhard.olzowy@med.uni-muenchen.de
authors.forename: Bernhard
authors.initials: B
authors.lastname: Olzowy
authors.forename: Gregor
authors.initials: G
authors.lastname: von Gleichenstein
authors.forename: Martin
authors.initials: M
authors.lastname: Canis
authors.forename: Klaus
authors.initials: K
authors.lastname: Mees
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D004432:Ear, Middle / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D010469:Perceptual Distortion / Q000502:physiology*