Synthesis and pharmacological activities of 7-azaindole derivatives.
As a part of our program to discover novel analogues of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine) having useful biological activities, some derivatives have been synthesized and evaluated for their analgesic and hypotensive activity. Compounds evaluated by thermal stimuli (tail immersion method) at the dose of 50 mg/kg of body weight revealed significant analgesic activity. Pethidine was used as reference drug. Same compounds tested at the dose of 75 mg/kg of body weight showed toxicity. Compounds tested for their effect on blood pressure in normotensive rat produced slight fall in blood pressure.
Mushtaq
Nousheen
N
Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan. noshin_mushtaq@yahoo.com
Saify
Z S
ZS
Noor
Fozia
F
Takween
Shamoona
S
Akhtar
Shamim
S
Arif
Muhammad
M
Khan
Khalid M
KM
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000959:Antihypertensive Agents; D001372:Aza Compounds; D007211:Indoles