title: [Left ventricular hypertrophy in predialysis chronic kidney disease: impact of cardiomuscular stress markers].
abstract: Left ventricular hypertrophy (LVH), which is a strong predictor of mortality in patients with endstage renal disease, is present in over 70% of patients commencing dialysis. However, only a few studies on LVH are available in patients before the start of dialysis treatment. The purpose of this study was to evaluate the prevalence and clinical correlates of LVH in patients with advanced stages of chronic kidney disease(CKD). We performed a cross sectional study of 90 patients who had renal diseases but no history of either cardiovascular diseases or arrhythmia. Circulating levels of human atrial natriuretic peptide (hANP) were also measured. LVH was present in 40.0% of the study population. The prevalence of LVH tended to increase with progression of renal decline: 22.7% in stage 3, 43.6% in stage 4, and 48.3% in stage 5 (creatinine clearance >10 mL/min) (p = 0.15). Univariate analyses revealed that hANP and albumin were significantly different between the groups with and without LVH. Stepwise logistic regression analysis showed that hANP and albumin were selected as the independent risk factors. These findings suggest that strict control of body fluid and nutrition could prevent the progression of LVH, and as a result, could attenuate the risk of cardiovascular events in CKD.
authors.affiliation: Department of Nephrology, Rinku General Medical Center, Izumisano Municipal Hospital.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kimura
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Iio
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Obi
authors.forename: Terumasa
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003956:Dialysis; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D009320:Atrial Natriuretic Factor