Swimming training exacerbates pathological cardiac hypertrophy in kinin B2 receptor-deficient mice.
Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B2 receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy characterized by normal organization of cardiac structure. Therefore, the aim of this work was to verify the influence of kinin B2 receptor deletion on physiological hypertrophy to exercise stimulus. Animals were submitted to swimming practice for 5 min or for 60 min, 5 days a week, during 1 month and several cardiac parameters were evaluated. Results showed no significantly difference in heart weight between both groups, however an increased left ventricle weight and myocyte diameter were observed after the 60 min swimming protocol, which was more pronounced in B2(-/-) mice. In addition, sedentary B2(-/-) animals presented higher left ventricle mass when compared to wild-type (WT) mice. An increase in capillary density was observed in exercised animals, however the effect was less pronounced in B2(-/-) mice. Collagen, a marker of pathological hypertrophy, was increased in B2(-/-) mice submitted to swimming protocol, as well as left ventricular thickness, suggesting that these animals do not respond with physiological hypertrophy for this kind of exercise. In conclusion, our data suggest an important role for the kinin B2 receptor in physiological cardiac hypertrophy.
Batista
Elice C
EC
Department of Biophysics of Universidade Federal de São Paulo, Brazil.
Batista
Eliza C
EC
Ramalho
João D S
JD
Reis
Felipe C G
FC
Barros
Carlos C
CC
Moraes
Milton R
MR
Pesquero
Jorge L
JL
Bacurau
Reury F P
RF
Pesquero
João B
JB
Araújo
Ronaldo C
RC
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology*; D003094:Collagen / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D005082:Physical Exertion; D043782:Receptor, Bradykinin B2 / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D013550:Swimming
D043782:Receptor, Bradykinin B2; D003094:Collagen