title: Disrupted cerebellar development in preterm infants is associated with impaired neurodevelopmental outcome.
abstract: The unfavorable impact of prematurity on the developing cerebellum was recently recognized, but the outcome after impaired cerebellar development as a prematurity-related complication is hitherto not adequately documented. Therefore we compared 31 preterm patients with disrupted cerebellar development to a control group of 31 gender and gestational age matched premature infants with normal cerebellar development. Supratentorial brain injuries during the neonatal period were comparable between the groups. At a minimum age of 24 months motor and mental development was assessed by standardized tests. Disrupted cerebellar development was associated with significantly poorer scores both in the subtests for neuromotor (p < 0.001) and mental development (p < 0.001), respectively. Mixed CP was diagnosed in 48% of affected patients, whereas none of the patients of the control group had mixed CP. Microcephaly and epilepsy were significantly related to disrupted cerebellar development. Preterm patients with disrupted cerebellar development exhibit poorer outcome results in all investigated variables. The role of the cerebellum in neurodevelopment after prematurity seems to be underestimated so far.
authors.affiliation: Division of General Pediatrics and Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. agnes.messerschmidt@meduniwien.ac.at
authors.forename: Agnes
authors.initials: A
authors.lastname: Messerschmidt
authors.forename: Renate
authors.initials: R
authors.lastname: Fuiko
authors.forename: Daniela
authors.initials: D
authors.lastname: Prayer
authors.forename: Peter C
authors.initials: PC
authors.lastname: Brugger
authors.forename: Eugen
authors.initials: E
authors.lastname: Boltshauser
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Zoder
authors.forename: Walter
authors.initials: W
authors.lastname: Sterniste
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.forename: Robert
authors.initials: R
authors.lastname: Birnbacher
mesh_terms: D002531:Cerebellum / Q000000981:diagnostic imaging / Q000254:growth & development / Q000293:injuries*; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D014463:Ultrasonography