title: Ti-catalyzed reformatsky-type coupling between alpha-halo ketones and aldehydes.
abstract: We describe the first Ti-catalyzed Reformatsky-type coupling between alpha-halo ketones and aldehydes. The reaction affords beta-hydroxy ketones under mild, neutral conditions compatible with ketones and other electrophiles. The catalytic cycle possibly proceeds via bis(cyclopentadienyl)titanium enolates.
authors.affiliation: Department of Organic Chemistry, University of Granada, Faculty of Sciences, Campus Fuentenueva s/n, E-18071 Granada, Spain.
authors.forename: Rosa E
authors.initials: RE
authors.lastname: Estévez
authors.forename: Miguel
authors.initials: M
authors.lastname: Paradas
authors.forename: Alba
authors.initials: A
authors.lastname: Millan
authors.forename: Tania
authors.initials: T
authors.lastname: Jiménez
authors.forename: Rafael
authors.initials: R
authors.lastname: Robles
authors.forename: Juan M
authors.initials: JM
authors.lastname: Cuerva
authors.forename: J Enrique
authors.initials: JE
authors.lastname: Oltra