title: Thymic carcinoid responds to neoadjuvant therapy with sunitinib and octreotide: a case report.
abstract: Carcinoids are malignant neuroendocrine tumors consisting of a spectrum of neoplasms from low-grade typical carcinoid to high-grade small cell carcinoma. We report a case of atypical thymic carcinoid that responded to neoadjuvant therapy with octreotide and sunitinib, an oral multikinase inhibitor. After 3 weeks of treatment, tumor size significantly decreased to allow for a safe surgical resection with clear margins. We believe that further study of sunitinib and octreotide with the neoadjuvant intent of preparing tumors for resection is warranted as a strategy to improve curative management of neuroendocrine tumors.
authors.affiliation: Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
authors.forename: Anu
authors.initials: A
authors.lastname: Dham
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Truskinovsky
authors.forename: Arkadiusz Z
authors.initials: AZ
authors.lastname: Dudek
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001707:Biopsy, Needle; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D019394:Ki-67 Antigen / Q000378:metabolism; D008206:Lymphatic Diseases / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000473:pathology; D009367:Neoplasm Staging; D015282:Octreotide / Q000627:therapeutic use*; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D011758:Pyrroles / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D000077210:Sunitinib; D016708:Synaptophysin / Q000378:metabolism; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007211:Indoles; D019394:Ki-67 Antigen; D011758:Pyrroles; D016708:Synaptophysin; D019009:Proto-Oncogene Proteins c-kit; D015282:Octreotide; D000077210:Sunitinib