Progressive trichodysplasia spinulosa in a patient with chronic lymphocytic leukaemia in remission.
A 70-year old Caucasian man with chronic lymphocytic leukaemia developed trichodysplasia spinulosa 2 months after ceasing chemotherapy. Histological features characteristic to this condition include dilated and enlarged hair follicles, hyperplastic hair bulbs, hyperplasia of inner root sheath cells with numerous large, eosinophilic, trichohyaline granules, and hypercornification. Although he was in remission for chronic lymphocytic leukaemia, lesions were slowly progressive 15 months after cessation of chemotherapy. We also describe a painless pull-test where spicules can be easily plucked and assessed microscopically for inner root sheath keratinization, or observed with surface microscopy in a clinic setting.
Lee
Joyce S-S
JS
Skin and Cancer Foundation Australia, Darlinghurst, NSW, Australia.
Frederiksen
Peter
P
Kossard
Steven
S
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006201:Hair Diseases / Q000175:diagnosis / Q000209:etiology*; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D016867:Immunocompromised Host; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy; D008297:Male; D012867:Skin / Q000473:pathology