Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury.
OBJECTIVE
To determine if people with spinal cord injury (SCI) have elevated C-reactive protein (CRP), to examine the association of CRP with high-density lipoprotein cholesterol (HDL-C), and to assess the influence of completeness and level of injury on these parameters.


METHODS
Cross-sectional.


METHODS
Urban university.


METHODS
Men with SCI (n=129) who were free of infection and/or recent anti-inflammatory medication use as well as their 1:1 age- and race-matched able-bodied counterparts from the 1999-2002 National Health and Nutrition Examination Surveys.


METHODS
Not applicable.


METHODS
High CRP was defined as 3 mg/L or higher and low HDL-C as less than 1.04 mmol/L.


RESULTS
Men with SCI were more likely to have high CRP (odds ratio [OR]=2.29; 95% confidence interval [CI], 1.33-3.95) and low HDL-C (OR=1.81; 95% CI, 1.01-3.27). The OR for low HDL-C in SCI was no longer significant when high CRP was controlled. CRP was higher in complete versus incomplete injury (median, 3.7 mg/L vs 1.2mg/L; P=.005), and this elevation was independent of age, smoking, physical activity, waist circumference, and weight. No conclusion can be made on the association of injury level and CRP because of a lack of power.


CONCLUSIONS
The elevated CRP, possibly the major risk factor, together with decreased HDL-C may contribute to greater incidence for cardiovascular disease in the SCI population.
Liang
Huifang
H
Department of Human Nutrition, University of Illinois, Chicago, IL 60612, USA.
Mojtahedi
Mina C
MC
Chen
David
D
Braunschweig
Carol L
CL
D000328:Adult; D000886:Anthropometry; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013119:Spinal Cord Injuries / Q000097:blood* / Q000453:epidemiology; D011795:Surveys and Questionnaires
D008076:Cholesterol, HDL; D002097:C-Reactive Protein