title: Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats.
abstract: Wilson's disease is an inherited, autosomal recessive disorder of copper accumulation and toxicity. Lifelong chelation therapy is essential in all Wilson's disease patients. Intestinal absorption of some compounds is limited partly because they are preferentially transported in the secretory direction. Several ATP-binding cassette (ABC) transporters are expressed in the apical membrane of the small intestine and secrete various drugs into the lumen. In this study, we investigated the characteristics of the intestinal efflux ABC transporters in LEC rats. We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased.
authors.affiliation: Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Chiba
authors.forename: Shirou
authors.initials: S
authors.lastname: Itagaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirano
authors.forename: Ken
authors.initials: K
authors.lastname: Iseki
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D015536:Down-Regulation; D006527:Hepatolenticular Degeneration / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000378:metabolism; D017035:Pravastatin / Q000378:metabolism; D011339:Probenecid / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D020332:Rats, Inbred LEC; D017208:Rats, Wistar; D013045:Species Specificity; D013448:Sulfobromophthalein / Q000494:pharmacology
chemical_list: D018528:ATP-Binding Cassette Transporters; C423013:Abcc2 protein, rat; D012333:RNA, Messenger; D013448:Sulfobromophthalein; D008353:Mannitol; D017035:Pravastatin; D011339:Probenecid