title: Two separated ileal adenocarcinomas in neurofibromatosis type 1.
abstract: Patients with neurofibromatosis-1 (NF-1) have increased susceptibility to a variety of malignancies. Here, we document a rare case of two separated ileal adenocarcinomas in NF-1. The adenocarcinomas were surrounded by a diffuse tubular adenomatous lesion of the mucosa, and ganglion cells were scattered in the NF background. We found this case meaningful for several reasons: two separated adenocarcinomas arising in an unusual ileal segment, the association with precancerous tubular adenoma, and the presence of ganglion cells, which suggests ganglioneuromatosis in NF-1.
authors.affiliation: Department of Radiology, College of Medicine, Catholic University of Korea, Daejeon St. Mary's Hospital, Deajeon, Korea.
authors.forename: Seal
authors.initials: S
authors.lastname: Hwangbo
authors.forename: Jiyoun
authors.initials: J
authors.lastname: Kim
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.forename: Jongok
authors.initials: J
authors.lastname: Kim
authors.forename: Changsuk
authors.initials: C
authors.lastname: Kang
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000328:Adult; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000473:pathology*; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology*