[Changes of prethrombotic state indexes in patients with malignant cancer].
OBJECTIVE
To study the changes and significance of prethrombotic state indexes in patients with malignant cancer.


METHODS
The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer.


RESULTS
The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P<0.05); the level of t-PA in the tumor group decreased compared with that in the control group (P<0.05). APTT and PT were significantly shortened in the tumor group (P<0.05). There was no significant changes of TT in 2 groups (P>0.05).


CONCLUSIONS
The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.
Abudoureyimu
Shajidan
S
Department of Immunology, Xinjiang Medical University, Xinjiang Autonomous Region, Urumqi 830054, China.
Zhang
Hong-liang
HL
Aizezi
Renaguli
R
Jin
Wei
W
Upur
Halmurat
H
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D019007:P-Selectin / Q000378:metabolism; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011517:Prothrombin Time; D013918:Thrombin Time; D010959:Tissue Plasminogen Activator / Q000097:blood*
D019332:Endothelin-1; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator