Clinical report of three cases of acute radiation sickness from a (60)Co radiation accident in Henan Province in China.
On 26 April 1999, three persons were accidentally exposed by high dose (60)Co irradiation. They suffered from severe (one case) or moderate (two cases) hemopoietic form of acute radiation sickness (ARS). As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied. All the patients recovered after an appropriate treatment for 83 days. In our experience, the correct diagnosis and effective treatment at an early stage proved to be helpful to the patients in pulling out from the critical stage of acute radiation sickness. To avoid menstruation by the female patient just in the critical stage, we modified her menstruation cycle by testosterone. In our view, GM-CSF should be given as early as possible with enough dosage for promoting early hematological reconstruction. The experience obtained from the medical management of these patients is valuable for the treatment of such patients in the future.
Liu
Qiang
Q
Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine,l First Clinical Department of Chinese Center for Medical Response to Radiation Emergency, Tianjin, China.
Jiang
Bo
B
Jiang
Li-Ping
LP
Wu
Ying
Y
Wang
Xiao-Guang
XG
Zhao
Feng-Ling
FL
Fu
Bao-Hua
BH
Istvan
Turai
T
Jiang
Enhai
E
D000328:Adult; D002648:Child; D002681:China; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000528:radiation effects; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology*; D018788:Radioactive Hazard Release; D012074:Remission Induction / Q000379:methods
D003037:Cobalt Radioisotopes; D016178:Granulocyte-Macrophage Colony-Stimulating Factor