Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis.
Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness.
Roiz-Santiáñez
Roberto
R
University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain.
Crespo-Facorro
Benedicto
B
Pérez-Iglesias
Rocío
R
Pelayo-Terán
José María
JM
Carrasco-Marín
Eugenio
E
Mata
Ignacio
I
Sánchez
Elena
E
Leyva-Cobián
Francisco
F
Vázquez-Barquero
José Luis
JL
D000483:Alleles; D020029:Base Pairing; D001921:Brain / Q000473:pathology*; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009778:Occipital Lobe / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein