Polyuria and polydipsia in a patient with non-small-cell lung cancer.
Tumor metastasis to the pituitary gland has been infrequently reported, and this is probably because only a small proportion of these patients are symptomatic. Most of the symptoms of this malady are related to diabetes insipidus. A 78-year-old man was diagnosed 2 years previously with stage IIIA adenocarcinoma of the lung and treated with sequential chemoradiation therapy and later with whole-brain radiation therapy because of newly developed brain metastasis; he was then admitted to our hospital with symptoms of polydipsia and polyuria. He was confirmed to have central diabetes insipidus that was caused by the pituitary metastasis from lung cancer. His symptoms resolved after treatment with desmopressin. Because of the rarity of this manifestation in lung cancer patients, we report on this case along with a brief review of the relevant literature.
Jung
Jae Wook
JW
Department of Internal Medicine, Korea Cancer Center Hospital, Gongneung-dong, Nowon-gu, Seoul, Korea.
Noh
Geum Youb
GY
Lee
Tae Hyeon
TH
Lee
Yun Yong
YY
Yi
Ka Hee
KH
Kim
Cheol Hyeon
CH
Lee
Jae Cheol
JC
D000368:Aged; D050034:Antidiuretic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D011141:Polyuria; D011859:Radiography; D013894:Thirst
D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin