title: Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study.
abstract: This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for -174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian (P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the -174 C/C genotype and IUGR was observed (P = 0.06). The -174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of -174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR.
authors.affiliation: Greater Manchester School for Professions Complementary to Dentistry, Salford Primary Care Trust, St James House, Pendleton Way, Salford, UK.
authors.forename: M
authors.initials: M
authors.lastname: Dashash
authors.forename: J
authors.initials: J
authors.lastname: Nugent
authors.forename: P
authors.initials: P
authors.lastname: Baker
authors.forename: D
authors.initials: D
authors.lastname: Tansinda
authors.forename: F
authors.initials: F
authors.lastname: Blinkhorn
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000235:genetics*; D010510:Periodontal Diseases / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D010512:Periodontal Index; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D011256:Pregnancy Outcome / Q000235:genetics*; D011446:Prospective Studies; D044465:White People / Q000235:genetics
chemical_list: D015850:Interleukin-6