title: Synthesis and biological evaluation of LNA phosphoramidates.
abstract: The synthesis of LNA phosphoramidates is presented. The LNA phosphoramidates were evaluated for their ability to inhibit cell proliferation of the human prostate cancer cell line 15PC3. A number of the LNA phosphoramidates showed cell proliferation inhibition determined by the MTS assay.
authors.affiliation: Santaris Pharma A/S, Hørsholm, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Jensen
authors.forename: Gitte
authors.initials: G
authors.lastname: Sjøgren
authors.forename: Jens Bo
authors.initials: JB
authors.lastname: Hansen
authors.forename: Christoph
authors.initials: C
authors.lastname: Rosenbohm
authors.forename: Troels
authors.initials: T
authors.lastname: Koch
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012266:Ribose / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: C434798:2'-O-4'-C-methylene-ribofuranosyl nucleotide; D000577:Amides; D009711:Nucleotides; D010756:Phosphoric Acids; D012266:Ribose; C011067:phosphoramidic acid