title: [Eradication of Helicobacter pylori: triple treatment scheme plus Lactobacillus vs. triple treatment alone].
abstract: BACKGROUND
  We undertook this study to determine the effectiveness of triple treatment associated with Lactobacillus casei strain Shirota against Helicobacter pylori, in comparison with triple conventional treatment without Lactobacillus.
  
  
  METHODS
  We designed a clinical comparative randomized study that included patients of both sexes infected by Helicobacter pylori. Patients were studied with endoscopy, biopsy and serology. Control group received traditional triple treatment with clarithromycin, amoxicillin and omeprazole, and the active group received the same treatment plus Lactobacillus casei strain Shirota. With the breath test at 8 weeks we determined the eradication of Helicobacter pylori.
  
  
  RESULTS
  In the active group we included 31 patients. After treatment, in 29 persons (94%) it was possible to eradicate the Helicobacter pylori. On the other hand, the control group was comprised of 33 patients who received only the traditional triple treatment; eradication was achieved in 25 patients (76%). Significant differences (p<0.05) were observed in favor of active group treatment.
  
  
  CONCLUSIONS
  Traditional triple treatment plus Lactobacillus casei strain Shirota is associated with a higher frequency of eradication of Helicobacter pylori than triple treatment alone.
authors.affiliation: Departamento de Medicina Interna y Gastroenterología, Hospital Valentín Gómez Farías, Instituto de Seguridad y Servicios Sociales de los Trabajadores de Estado, Guadalajara, Jalisco.
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: Sahagún-Flores
authors.forename: Luis Salvador
authors.initials: LS
authors.lastname: López-Peña
authors.forename: Juan
authors.initials: J
authors.lastname: de la Cruz-Ramírez Jaimes
authors.forename: Mónica Susana
authors.initials: MS
authors.lastname: García-Bravo
authors.forename: Rosalba
authors.initials: R
authors.lastname: Peregrina-Gómez
authors.forename: Javier Eduardo García
authors.initials: JE
authors.lastname: de Alba-García
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000628:therapy*; D016480:Helicobacter pylori; D006801:Humans; D007780:Lacticaseibacillus casei; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents