Association of the serotonin transporter gene, neuroticism and smoking behaviours.
Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.
O'Gara
Colin
C
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK. colin.ogara@sjog.ie.|St. John of God Hospital, Stillorgan, Co Dublin, Ireland. colin.ogara@sjog.ie.
Knight
Jo
J
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Stapleton
John
J
Tobacco Research Unit, National Addiction Centre, Institute of Psychiatry, London, UK.
Luty
Jason
J
South Essex Partnership NHS Trust, The Taylor Centre, Queensway House, Essex Street, Southend on Sea, Essex, SS4 1RB, UK.
Neale
Ben
B
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Nash
Matt
M
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Heuzo-Diaz
Patricia
P
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Hoda
Farzana
F
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Cohen
Sarah
S
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Sutherland
Gay
G
Tobacco Research Unit, National Addiction Centre, Institute of Psychiatry, London, UK.
Collier
David
D
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Sham
Pak
P
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Ball
David
D
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
McGuffin
Peter
P
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
Craig
Ian
I
MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
D016001:Confidence Intervals; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009497:Neurotic Disorders / Q000235:genetics* / Q000523:psychology; D010551:Personality; D040641:Quantitative Trait Loci; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D016540:Smoking Cessation / Q000706:statistics & numerical data
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins