Rab proteins in endocytosis and Glut4 trafficking.
The intracellular trafficking of numerous proteins requires a tight control to fulfil their physiological functions. It is the case of the adipocyte and muscle glucose transporter Glut4 that is retained intracellularly until insulin induces its recruitment to the plasma membrane. Rabs are evolutionarily conserved small GTPases that control intracellular traffic events from yeast to mammalian cells. In the past few decades, considerable progresses have been made in identifying the route of Glut4, the Rabs involved in controlling it, and more recently the connection between insulin signalling and Glut4 trafficking through Rab activity control.
Kaddai
V
V
Institut National de la Santé et de la Recherche Médicale INSERM U568 Faculté de Médecine, Université de Nice-Sophia Antipolis, Nice Cedex, France.
Le Marchand-Brustel
Y
Y
Cormont
M
M
D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000502:physiology*
D051275:Glucose Transporter Type 4; D007328:Insulin; D020691:rab GTP-Binding Proteins