Role of quercetin (a natural herbal compound) in allergy and inflammation.
An investigated flavonoid, quercetin, is reviewed in this article. Quercetin is a bioflavonoid found in red wine, grapefruit, onions, apples, black tea, and, in lesser amounts, in leafy green vegetables and beans. Quercetin has an antioxidant and anti-inflammatory activity and prevents cancer. Quercitin inhibits the growth of certain malignant cells in vitro, and histamine and most cyclin-dependent kinases and also displays unique anticancer properties. Quercetin is a natural compound that blocks substances involved in allergies and is able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase, MCP-1 and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from few mast cell lines. Quercetin is a safe, natural therapy that may be used as primary therapy or in conjunction with conventional methods.
Shaik
Y B
YB
Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, MA, USA.
Castellani
M L
ML
Perrella
A
A
Conti
F
F
Salini
V
V
Tete
S
S
Madhappan
B
B
Vecchiet
J
J
De Lutiis
M A
MA
Caraffa
A
A
Cerulli
G
G
D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects; D011794:Quercetin; D053802:Tryptases
D011794:Quercetin; D053802:Tryptases