Acupuncture stimulation at Sanyinjiao: effect on the sodium pertechnetate bioavailability in rats.
In clinical acupuncture, when acupuncture points are stimulated, several types of reflex responses can be evoked. Consequently, different categories of physiological responses are induced, which include changes in the activities of internal organs and tissues. The acupuncture point Sanyinjiao (SP6) has been used successfully to treat different human gastrointestinal conditions. The aim of this work was to investigate the effects of end-organ response induced by acupuncture point SP6 on the bioavailability of the radiopharmaceutical sodium pertechnetate (Na99mTcO4) in Wistar rats. Healthy rats were allocated into 2 groups, control-CG and treated-TG. TG was bilaterally stimulated at acupuncture point SP6 with stainless steel needles. Ocular plexus administration of Na99mTcO4 (3.7MBq) was carried out 10 min after every needle insertion in all animals. Ten minutes later, the animals were killed, the organs were isolated, the radioactivity was determined in a well gamma counter, and the percentage of injected dose per gram of tissue (%ID/g) was determined for each organ. The %ID/g was significantly altered (p < 0.05) in the small intestine of TG (0.56 +/- 0.09) when compared to CG (0.82 +/- 0.18). These results may suggest that this stimulation might induce physiological responses capable of altering the bioavailability of the radiopharmaceutical sodium pertechnetate. These findings aid in providing a better understanding of acupuncture and its effects on various organs and tissues.
de Souza
Deise Elisabete
DE
Laboratório de Radiofarmácia Experimental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. deise_desouza@yahoo.com.br
Senna-Fernandes
Vasco
V
de Carvalho Brito
Lavínia
L
de Souza
Raphael Sancho Sisley
RS
França
Daisy
D
Manoel
Cristiano Viana
CV
de Almeida
Marcela Ceciliano
MC
Bernardo-Filho
Mario
M
D026881:Acupuncture / Q000379:methods*; D015669:Acupuncture Points; D000818:Animals; D001682:Biological Availability; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism
D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m