High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.
Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.
Henchoz
Yveline
Y
Unité de Pharmacochimie, School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Quai E-Ansermet 30, Geneva, Switzerland.
Guillarme
Davy
D
Rudaz
Serge
S
Veuthey
Jean-Luc
JL
Carrupt
Pierre-Alain
PA
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002627:Chemistry, Physical; D002853:Chromatography, Liquid / Q000379:methods; D008433:Mathematics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012984:Software
D004364:Pharmaceutical Preparations