Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss.
Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.
Ozawa
Nobuaki
N
Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan. nobu0822@aol.com
Maruyama
Tetsuo
T
Nagashima
Takashi
T
Ono
Masanori
M
Arase
Toru
T
Ishimoto
Hitoshi
H
Yoshimura
Yasunori
Y
D000026:Abortion, Habitual / Q000453:epidemiology* / Q000235:genetics*; D000328:Adult; D025063:Chromosome Disorders / Q000453:epidemiology* / Q000235:genetics*; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*