title: Primary pure large-cell neuroendocrine carcinoma of the ovary.
abstract: We report a case of a 73-year-old female with a rare simultaneous occurrence of three tumors: ovarian carcinoma, endometrial carcinoma, and breast carcinoma. The ovarian tumor was a primary pure large-cell neuroendocrine carcinoma. Grossly, the left ovary was enlarged by a solid tumor that measured 9 x 7 x 7 cm. Histologically, the tumor consisted of large cells with irregular hyperchromatic nuclei and a moderate amount of eosinophilic cytoplasm. In some areas, the tumor cells were arranged in solid sheets; however, the predominant pattern was cribriform and solid-alveolar, with palisaded tumor cells located peripherally. The tumor cells showed multiple mitotic figures (up to 43 mitoses/10 HPF). Large areas of tumor necrosis were found. Immunohistochemically, the tumor cells were positive for EMA, synaptophysin, chromogranin, CD56, and CEA. Cytokeratin 20 was positive focally. Primary large-cell neuroendocrine carcinoma of the ovary is a rare tumor. To the best of our knowledge, only 4 cases of a pure tumor of this type have been reported to date.
authors.affiliation: Department of Pathology, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Studnickova 2, Prague 12800, Czech Republic. pdundr@seznam.cz
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Daniela
authors.initials: D
authors.lastname: Fischerová
authors.forename: Ctibor
authors.initials: C
authors.lastname: Povýsil
authors.forename: David
authors.initials: D
authors.lastname: Cibula
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000737:chemistry / Q000276:immunology / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology; D019002:CD56 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018287:Carcinoma, Large Cell / Q000737:chemistry / Q000276:immunology / Q000556:secondary* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000276:immunology / Q000556:secondary* / Q000628:therapy; D002864:Chromogranins / Q000032:analysis; D016889:Endometrial Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D016708:Synaptophysin / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D019002:CD56 Antigen; D002272:Carcinoembryonic Antigen; D002864:Chromogranins; D016708:Synaptophysin