[The prospect of application of toxicogenetics/pharmcogenetics theory and methods in forensic practice].
Individual response to drugs, toxicants, environmental chemicals and allergens varies with genotype. Some respond well to these substances without significant consequences, while others may respond strongly with severe consequences and even death. Toxicogenetics and toxicogenomics as well as pharmacogenetics explain the genetic basis for the variations of individual response to toxicants by sequencing the human genome and large-scale identification of genome polymorphism. The new disciplines will provide a new route for forensic specialists to determine the cause of death.
Shen
Dan-na
DN
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. bananashenyipeng@163.com
Yi
Xu-fu
XF
Chen
Xiao-gang
XG
Xu
Tong-li
TL
Cui
Li-juan
LJ
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004342:Drug Hypersensitivity / Q000235:genetics; D005554:Forensic Medicine; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends; D010599:Pharmacokinetics; D020641:Polymorphism, Single Nucleotide; D043922:Toxicogenetics / Q000639:trends
D003577:Cytochrome P-450 Enzyme System