Gatifloxacin-associated hypoglycemia.
Fluoroquinolone antibiotics are widely employed in treating infectious diseases. Lately, reports of either hyperglycemia or hypoglycemia have appeared in the medical literature. Many patients are elderly and have underlying diabetes and renal insufficiency. Of these antibiotics, dysglycemia occurs more frequently with gatifloxacin (Tequin). While hypoglycemia usually occurs within the first three days of treatment, hyperglycemia often occurs later in the treatment course. The hypoglycemia may be profound and difficult to manage. We report 4 patients with hypoglycemia while taking gatifloxacin and review the relevant literature.
Ali
Tauseef
T
Department of Medicine, University of Oklahoma, Williams Pavilion, 1140 920 Stanton Young Blvd., OKC, OK 73104, USA.
Greenfield
Ronald A
RA
Scofield
Hal
H
Bronze
Michael S
MS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D000077734:Gatifloxacin; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000150:complications; D008297:Male
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin