X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus.
Bacillus cereus Hemolysin BL enterotoxin, a ternary complex of three proteins, is the causative agent of food poisoning and requires all three components for virulence. The X-ray structure of the binding domain of HBL suggests that it may form a pore similar to other soluble channel forming proteins. A putative pathway of pore formation is discussed.
Madegowda
Mahendra
M
Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA.
Eswaramoorthy
Subramaniam
S
Burley
Stephen K
SK
Swaminathan
Subramanyam
S
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry*; D000595:Amino Acid Sequence; D001409:Bacillus cereus / Q000737:chemistry; D003001:Cloning, Molecular; D003460:Crystallization; D018360:Crystallography, X-Ray; D006460:Hemolysin Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D016415:Sequence Alignment
D018528:ATP-Binding Cassette Transporters; D006460:Hemolysin Proteins; C086257:hemolysin B