Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: a multicenter longitudinal survey in Germany and Austria.
OBJECTIVE
Arterial blood pressure was followed in 868 patients with type 1 diabetes aged 6.0-19.9 years in 95 centers in Germany and Austria.


METHODS
European blood pressure reference data for 28,043 children and adolescents were used with respect to age and sex. Data were stratified into three groups: prepubertal, pubertal, and postpubertal.


RESULTS
Up to 4% of the participants in the younger age-groups and 13.9% of the postpubertal patients exhibited blood pressure values >97th centile. Blood pressure levels correlated with A1C level and BMI Z score. Tracking of blood pressure revealed that children with elevated blood pressure had higher blood pressure in adolescence and young adulthood.


CONCLUSIONS
Patients with higher blood pressure in childhood showed elevated blood pressure later in life. We need to focus on the diagnosis of hypertension in children with type 1 diabetes and to study the efficacy of early intervention.
Knerr
Ina
I
Children's and Adolescents' Hospital, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany. ina.knerr@uk-erlangen.de
Dost
Axel
A
Lepler
Rudolf
R
Raile
Klemens
K
Schober
Edith
E
Rascher
Wolfgang
W
Holl
Reinhard W
RW
D000293:Adolescent; D000328:Adult; D001317:Austria / Q000453:epidemiology; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003971:Diastole; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D013599:Systole