title: PRODH gene is associated with executive function in schizophrenic families.
abstract: The aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first-episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests. Neuropsychological measures were selected as quantitative traits for association analysis. The haplotype of SNPs PRODH 1945T/C and PRODH 1852G/A was associated with impaired performance on the Tower of Hanoi, a problem-solving task mainly reflecting planning capacity. There was no significant evidence for association with any other neuropsychological traits for other SNPs or haplotypes of paired SNPs in the two genes. This study takes previous findings of association between PRODH and schizophrenia further by associating variation within the gene with performance on a neurocognitive trait characteristic of the illness. It fails to confirm previous reports of an association between COMT and cognitive function.
authors.affiliation: Psychiatric Laboratory, Department of Psychiatry, West China Hospital, Sichuan University, Sichuan, China. sphatal@iop.kcl.ac.uk
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengying
authors.initials: C
authors.lastname: Yan
authors.forename: Huaqing
authors.initials: H
authors.lastname: Meng
authors.forename: Xiehe
authors.initials: X
authors.lastname: Liu
authors.forename: Timothea
authors.initials: T
authors.lastname: Toulopoulou
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: David A
authors.initials: DA
authors.lastname: Collier
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003071:Cognition / Q000502:physiology; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011394:Proline Oxidase / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D011394:Proline Oxidase; D002394:Catechol O-Methyltransferase