title: Randomized, controlled trial efficacy of pneumococcal conjugate vaccine against otitis media among Navajo and White Mountain Apache infants.
abstract: We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. Efficacy was -0.4% (95% CI: -19.4 to 15.6) for clinically-diagnosed OM, 5.1% (95% CI: -51.5 to 40.6) for severe OM, and 64% (95% CI: -34% to 90%) for vaccine serotype pneumococcal OM suggesting that this vaccine is efficacious for pneumococcal OM in this high risk population.
authors.affiliation: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. klobrien@jhsph.edu
authors.forename: Katherine L
authors.initials: KL
authors.lastname: O'Brien
authors.forename: Angeline B
authors.initials: AB
authors.lastname: David
authors.forename: Aruna
authors.initials: A
authors.lastname: Chandran
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Moulton
authors.forename: Raymond
authors.initials: R
authors.lastname: Reid
authors.forename: Robert
authors.initials: R
authors.lastname: Weatherholtz
authors.forename: Mathuram
authors.initials: M
authors.lastname: Santosham
mesh_terms: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007198:Indians, North American; D007223:Infant; D022401:Meningococcal Vaccines / Q000276:immunology* / Q000627:therapeutic use; D010033:Otitis Media / Q000276:immunology / Q000628:therapy*; D011008:Pneumococcal Infections / Q000276:immunology* / Q000628:therapy*; D022242:Pneumococcal Vaccines / Q000276:immunology* / Q000627:therapeutic use; D014481:United States
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines