title: Predictive value of D-dimer for portal vein thrombosis after portal hypertension surgery in hepatitis B virus-related cirrhosis.
abstract: OBJECTIVE
  To evaluate the predictive value of D-dimer as a predictive indicator of portal vein thrombosis (PVT) after portal hypertension surgery in hepatitis B virus-related cirrhosis.
  
  
  METHODS
  A prospective study was carried out in 52 patients who had undergone surgery for portal hypertension in hepatitis B virus-related cirrhosis. Changes in perioperative dynamic D-dimer were observed. The sensitivity, specificity, positive predictive values and negative predictive values of D-dimer were calculated, and ROC curves were analyzed.
  
  
  RESULTS
  The D-dimer levels in the group developing postoperative PVT was significantly higher than those in the group not developing PVT (P = 0.001), and the ROC semiquantitative and qualitative analysis of D-dimer showed a moderate predictive value in PVT (semi-quantitative value Az = 0.794, P = 0.000; qualitative analysis: Az = 0.739, P = 0.001).
  
  
  CONCLUSIONS
  Dynamic monitoring of D-dimer levels in patients with portal hypertension after surgery can help early diagnosis of PVT, as in cases where the D-dimer levels steadily increase and exceed 16 microg/mL, the possibility of PVT is very high.
authors.affiliation: Department of Hepato-biliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. drdmh@medmail.com.cn
authors.forename: Mei-Hai
authors.initials: MH
authors.lastname: Deng
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Fang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Pan
authors.forename: Zhao-Feng
authors.initials: ZF
authors.lastname: Tang
authors.forename: Peng
authors.initials: P
authors.lastname: Deng
authors.forename: Yue-Si
authors.initials: YS
authors.lastname: Zhong
authors.forename: Rui-Yun
authors.initials: RY
authors.lastname: Xu
mesh_terms: D000328:Adult; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000472:pathogenicity; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000601:surgery*; D008099:Liver / Q000098:blood supply / Q000601:surgery / Q000821:virology; D008103:Liver Cirrhosis / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D