A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura.
Minor CLL-like clones are found in approximately 3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans' Syndrome, compared with 26 age-matched healthy controls. A population of 'CLL phenotype' was seen in 6/31 patients compared to 1/26 healthy controls (chi(2)=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.
Mittal
Sajjan
S
Blaylock
Morgan G
MG
Culligan
Dominic J
DJ
Barker
Robert N
RN
Vickers
Mark A
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D002469:Cell Separation; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D010641:Phenotype; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000235:genetics; D013577:Syndrome