[Serum leptin with bone mineral density and body fat mass in males].
OBJECTIVE
To determine the relationship of serum leptin concentration and bone mineral density(BMD), body fat mass in males.


METHODS
Plasma concentrations of leptin in 350 Chinese males, aged 20 to 80 years were measured with ELISA; BMD values at lumbar spine, hip and total body BMD, and body composition, including lean tissue mass (LTM) and fat tissue mass (FTM), were measured using dual-energy-X-ray absorptiometry (DXA). The relationship between changes in serum leptin concentration with age, body weight, body mass index, body fat mass, and BMD values at 5 skeletal sites was fit by 10 regression models, and the models giving the best fit were selected.


RESULTS
The S regression model best described the changes in serum leptin level with age (R(2)=0.104, P<0.009), while the compound regression model best described the changes in serum leptin concentration with BMI and weight (R(2)=0.296, P<0.001; R(2) =0.304, P<0.001). Leptin concentration was correlated with FTM (R(2)=0.448, P<0.001) and rate of body fat(R(2)=0.461, P<0.001). The serum leptin level was significantly correlated with BMD of multiple skeletal sites (R(2) was 0.115 for anterior spine BMD, 0.102 for lateral spine BMD,0.098 for femoral neck BMD, 0.112 for total hip BMD, respectively). In a multivariate analysis, leptin concentration was not a significant predictor of BMD at any site.


CONCLUSIONS
Serum leptin concentration correlates with body fat mass and percentage of body fat, but is not a significant predictor of BMD at any site in Chinese males.
Jiang
Yue-xia
YX
Institue of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha 410011, China. lansu2006@21cn.com
Tang
Si-yuan
SY
Wu
Xian-ping
XP
Yang
Ling-feng
LF
Liao
Er-yuan
EY
D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D020738:Leptin