The J-Tip Needle-Free Injection System in controlled ovarian hyperstimulation in in vitro fertilization: a pilot study.
OBJECTIVE
To evaluate the use of a novel needle-free system (J-Tip) in the administration of gonadotropins for controlled ovarian hyperstimulation (COH) in IVF.


METHODS
An open-label, single-center, pilot study.


METHODS
Assisted conception unit of a university hospital.


METHODS
Twenty patients undergoing COH over a 3-month period.


METHODS
COH was carried out using a fixed dose of rFSH administered via the J-Tip System in a GnRH antagonist cycle.


METHODS
The primary endpoint was the mean number of oocytes collected per patient, and secondary endpoints were incidence of technically correct injections, clinical pregnancy, and cancellation rates. Patient diaries were kept throughout the study.


RESULTS
Sixteen patients completed the trial, four of whom became pregnant, with a high overall satisfaction rate.


CONCLUSIONS
This is the first report of the use of the novel J-Tip Needle-Free Injection System for administration of gonadotropins in IVF with successful ovarian stimulation and achievement of pregnancies. This report indicates that this technique is associated with minimal pain and high patient acceptability. Large-scale multicenter studies are required to examine the reproducibility of these results and the J-Tip's cost-effectiveness as well as to compare the J-tip System with conventional needle-wise administration for COH before its introduction into routine IVF practice.
Lavery
Stuart A
SA
Department of Reproductive Medicine and Surgery, Assisted Conception Unit, Hammersmith Hospital, Imperial College School of Medicine, London, United Kingdom.
El-Shawarby
Salem A
SA
Turner
Cathy
C
Trew
Geoffrey
G
D000328:Adult; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004624:Embryo Transfer; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007246:Infertility / Q000378:metabolism / Q000628:therapy*; D007267:Injections; D054315:Oocyte Retrieval; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D010062:Ovulation Induction / Q000009:adverse effects / Q000295:instrumentation*; D017060:Patient Satisfaction; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome; D055815:Young Adult
D005300:Fertility Agents, Female; D006727:Hormone Antagonists; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone