title: Incidence and risk factors of insulin resistance syndrome in 20-59 year-old Korean male workers.
abstract: We investigated the incidence of insulin resistance syndrome (IRS) according to the criteria of diagnoses suggested by the American College of Endocrinology/ American Association of Clinical Endocrinologists and the risk factors associated with the development of IRS. Among 2,048 subjects without a history of/or drug treatment for hypertension, diabetes, dyslipidemia with normal findings at baseline, 1,578 subjects aged 20-59 yr were followed prospectively for 2 yr. The incidence of IRS was 6.9 per 100 persons/year. The relative risk (RR) due to age was 1.03 (95% CI: 1.00-1.05) with every one-year increase in age. The RR associated with an abnormal waist-hip ratio group (> or =0.9) was increased by 1.74 (95% CI: 1.17-2.58) compared to the normal group (<0.9); RR associated with abnormal alanine transferase was increased (> or =35 IU/L) by 1.70 (95% CI: 1.20-2.41) compared to the normal group (<35 IU/L); and the RR associated with abnormal lowdensity lipoprotein (LDL) cholesterol was increased (> or =160 mg/L) by 1.70 (95% CI: 1.19-2.44) compared to the normal LDL cholesterol (<160 mg/L). Lastly, the RR of current smokers was increased by 1.63 (95% CI: 1.09-2.42) compared to that of non-smokers. It is necessary to develop methods of prevention and therapeutic approach to manage the integrated risk factors as opposed to individual factors.
authors.affiliation: Health Management Division, Radiation Health Research Institute, Korea Hydro and Nuclear Power. Co., LTD., Seoul, Korea. ksg6201@empal.com
authors.forename: Soo Geun
authors.initials: SG
authors.lastname: Kim
authors.forename: Hyun Sul
authors.initials: HS
authors.lastname: Lim
authors.forename: Hae Kwan
authors.initials: HK
authors.lastname: Cheong
authors.forename: Chong Soon
authors.initials: CS
authors.lastname: Kim
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Seo
mesh_terms: D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D049629:Waist-Hip Ratio
chemical_list: D008078:Cholesterol, LDL; D000410:Alanine Transaminase