Cytotoxic constituents from the leaves of Cinnamomum subavenium.
Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1-3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose- and time-dependent manner.
Kuo
Soong-Yu
SY
School of Medicine and Health Sciences, Fooyin University, Taiwan.
Hsieh
Tian-Jye
TJ
Wang
Yau-Der
YD
Lo
Wen-Li
WL
Hsui
Yen-Ray
YR
Chen
Chung-Yi
CY
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D027424:Cinnamomum / Q000737:chemistry*; D004249:DNA Damage; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
D000972:Antineoplastic Agents, Phytogenic; C525771:secosubamolide A; C525769:subamolide D; C525770:subamolide E; D015107:4-Butyrolactone