title: Association study between obsessive-compulsive disorder and serotonergic candidate genes.
abstract: BACKGROUND
  To date, research examining the relationship between serotonergic genes and obsessive-compulsive disorder (OCD) has yielded conflicting results. The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD.
  
  
  METHODS
  99 OCD patients, 456 non-OCD psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods.
  
  
  RESULTS
  All groups showed Hardy-Weinberg equilibrium for the analyzed genetic variability. A-1438G and T102C polymorphisms were in complete linkage disequilibrium. OCD patients showed an excess of STin2.12 carriers (12/12, 12/10, and 12/9 genotypes) compared with healthy controls (chi(2) (1)=7.21, corrected p=0.021; OR=3.38, 95% CI=1.32-8.62) and non-OCD psychiatric patients (chi(2) (1)=6.70, corrected p=0.030; OR=3.24, 95% CI=1.27-8.26). However, no differences were found between non-OCD patients and healthy controls (chi(2) (1)=0.05, corrected p>1; OR=1.04, 95% CI=0.72-1.51). No significant differences were found with respect to A-1438G and 5-HTTLPR polymorphisms.
  
  
  CONCLUSIONS
  Our data provide supporting evidence of an association between the STin2 VNTR polymorphism of the SLC6A4 gene and OCD.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Oviedo, Julian Claveria 6-3, 33006 Oviedo, Spain. frank@uniovi.es
authors.forename: Pilar A
authors.initials: PA
authors.lastname: Saiz
authors.forename: Maria P
authors.initials: MP
authors.lastname: Garcia-Portilla
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Maria-Teresa
authors.initials: MT
authors.lastname: Bascaran
authors.forename: Sara
authors.initials: S
authors.lastname: Martinez-Barrondo
authors.forename: Gerardo
authors.initials: G
authors.lastname: Florez
authors.forename: Emilio
authors.initials: E
authors.lastname: Sotomayor
authors.forename: Begoña
authors.initials: B
authors.lastname: Paredes
authors.forename: Cesar
authors.initials: C
authors.lastname: Alvarez
authors.forename: Gema
authors.initials: G
authors.lastname: San Narciso
authors.forename: Eduardo
authors.initials: E
authors.lastname: Carreño
authors.forename: Igor
authors.initials: I
authors.lastname: Bombin
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Juan M
authors.initials: JM
authors.lastname: Fernandez
authors.forename: Manuel
authors.initials: M
authors.lastname: Bousoño
authors.forename: Julio
authors.initials: J
authors.lastname: Bobes
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins