Preparation of a bonelike apatite-polymer fiber composite using a simple biomimetic process.
A bonelike apatite-polymer fiber composite may be useful as an implant material to replace bone, the enthesis of a tendon, and the joint part of a ligament. We treated an ethylene-vinyl alcohol copolymer (EVOH) plate and knitted EVOH fibers with an oxygen plasma to produce oxygen-containing functional groups on their surfaces. The plasma-treated samples were alternately dipped in alcoholic calcium and phosphate ion solutions three times to deposit apatite precursors onto their surfaces. The surface-modified samples formed a dense and uniform bonelike surface apatite layer after immersion for 24 h in a simulated body fluid with ion concentrations approximately equal to those of human blood plasma. The adhesive strength between the apatite layer and the sample's surface increased with increasing power density of the oxygen plasma. The apatite-EVOH fiber composite obtained by our process has similarities to natural bone in that apatite crystals are deposited on organic polymer fibers. The resulting composite would possess osteoconductivity due to the apatite phase. With proper polymer selection and optimized synthesis techniques, a composite could be made that would have bonelike mechanical properties. Hence, the present surface modification and coating process would be a promising route to obtain new implant materials with bonelike mechanical properties and osteoconductivity.
Yokoyama
Yoshiro
Y
National Institute of Advanced Industrial Science and Technology, Nanotechnology Research Institute, Central 4, 1-1-1 Higashi, Tsukuba-shi, Ibaraki 305-8562, Japan.
Oyane
Ayako
A
Ito
Atsuo
A
D001031:Apatites; D032701:Biomimetics / Q000379:methods*; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D019563:Mechanics; D011108:Polymers; D011145:Polyvinyls; D013499:Surface Properties
D001031:Apatites; D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer; C020243:calcium phosphate