title: Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines.
abstract: The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The M.S University of Baroda, Kalabhavan, Vadodara 390 001, India.
authors.forename: R
authors.initials: R
authors.lastname: Ramajayam
authors.forename: Rajani
authors.initials: R
authors.lastname: Giridhar
authors.forename: M R
authors.initials: MR
authors.lastname: Yadav
authors.forename: R
authors.initials: R
authors.lastname: Balaraman
authors.forename: Hakim
authors.initials: H
authors.lastname: Djaballah
authors.forename: David
authors.initials: D
authors.lastname: Shum
authors.forename: Constantin
authors.initials: C
authors.lastname: Radu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; D010975:Platelet Aggregation Inhibitors