title: Intermediate-term outcomes of hepatitis C-positive compared with hepatitis C-negative deceased-donor renal allograft recipients.
abstract: BACKGROUND
  Prior studies have yielded conflicting results concerning the impact of HCV on renal transplant outcomes.
  
  
  METHODS
  We examined outcomes in comparable groups of predominantly African American hepatitis C virus (HCV)-positive (n = 34) and HCV-negative (n = 111) kidney transplant patients receiving contemporary immunosuppression.
  
  
  RESULTS
  There was no difference in patient survival or acute rejection, but new-onset diabetes (NODM) was increased and graft survival decreased in the HCV-positive group, with increased graft loss secondary to noncompliance and Type I MPGN. The incidence of NODM among patients undergoing early corticosteroid withdrawal was 11% in both groups, while among those on prednisone, it was 47% in HCV-positive versus 25% in HCV-negative recipients.
  
  
  CONCLUSIONS
  Deceased-donor HCV-positive renal allograft recipients have equivalent patient but decreased graft survival. Noncompliance and Type I MPGN play a role in producing this negative effect on graft outcome. Steroids may be required for HCV to exert its diabetogenicity in kidney transplant patients.
authors.affiliation: Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: Kristian L
authors.initials: KL
authors.lastname: Brown
authors.forename: Jose M
authors.initials: JM
authors.lastname: El-Amm
authors.forename: Mona D
authors.initials: MD
authors.lastname: Doshi
authors.forename: Atul
authors.initials: A
authors.lastname: Singh
authors.forename: Katherina
authors.initials: K
authors.lastname: Morawski
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cincotta
authors.forename: Firdous
authors.initials: F
authors.lastname: Siddiqui
authors.forename: Julian E
authors.initials: JE
authors.lastname: Losanoff
authors.forename: Miguel S
authors.initials: MS
authors.lastname: West
authors.forename: Scott A
authors.initials: SA
authors.lastname: Gruber
mesh_terms: D003920:Diabetes Mellitus; D005260:Female; D006085:Graft Survival; D006526:Hepatitis C; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome