title: Low adiponectin levels predict late in-stent restenosis after bare metal stenting in native coronary arteries.
abstract: BACKGROUND
  Adiponectin, the most abundant protein secreted from adipose tissue, possesses anti-atherogenic properties. This study tested whether adiponectin plasma levels predict in-stent restenosis (ISR) after successful percutaneous coronary intervention (PCI) with bare-metal stents.
  
  
  METHODS
  The study included 148 consecutive patients who had elective PCI with bare-metal stents in de novo lesions of native coronary arteries for symptomatic coronary artery disease. Adiponectin levels were measured by ELISA 3 days or less before PCI.
  
  
  RESULTS
  Angiographic ISR (defined as >50% diameter stenosis) was found in 49 (33%) patients during 6 months of the follow-up. Adiponectin levels were lower in patients with ISR than those without ISR (3.5+/-0.3 vs. 6.9+/-0.4 microg/ml, respectively, p<0.01). Adiponectin levels were inversely correlated with late luminal loss of the stented lesions (r=-0.40, p<0.01). Using multivariate logistic regression analysis, low adiponectin levels (<4.5 microg/ml, arbitrarily determined from a receiver operating characteristic curve) served as a predictor of ISR that was independent of angiographic and procedural variables, and clinical factors known to be associated with ISR (odds ratio, 7.9; 95% CI, 3.0-21; p<0.01). Furthermore, low adiponectin levels also independently predicted target lesion revascularization (n=35) during follow-up (odds ratio, 3.7; 95% CI, 1.4-9.7; p<0.01).
  
  
  CONCLUSIONS
  Low adiponectin levels have a predictive value for late ISR after PCI with bare-metal stents in native coronary arteries.
authors.affiliation: Department of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kitta
authors.forename: Hajime
authors.initials: H
authors.lastname: Takano
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kodama
authors.forename: Ken
authors.initials: K
authors.lastname: Umetani
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujioka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Saito
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Jyun-Ei
authors.initials: JE
authors.lastname: Obata
authors.forename: Akira
authors.initials: A
authors.lastname: Mende
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kugiyama
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D023903:Coronary Restenosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D003331:Coronary Vessels / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015607:Stents / Q000009:adverse effects; D013997:Time Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers