title: Positron emission tomography for use in microdosing studies.
abstract: Positron emission tomography (PET) imaging using microdoses of radiolabeled drug tracers is gaining increasing acceptance in modern clinical drug development. This approach is unique in that it allows for direct quantitative assessment of drug concentrations in the tissues targeted for treatment, thereby bridging the gap between pharmacokinetics and pharmacodynamics. Current applications of PET in anticancer, anti-infective and central nervous system drug research are reviewed herein. Situated at the interface of preclinical and clinical drug testing, PET microdosing is a powerful and highly innovative tool for pharmaceutical development.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Claudia Christina
authors.initials: CC
authors.lastname: Wagner
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Graham
authors.initials: G
authors.lastname: Lappin
authors.forename: Oliver
authors.initials: O
authors.lastname: Langer
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D010600:Pharmacology / Q000379:methods / Q000639:trends; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations; D019275:Radiopharmaceuticals