title: The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.
abstract: Little is known about the effects of weight loss on diastolic function. Furthermore, it is not known whether both caloric restriction (CR)- and exercise (Ex)-induced weight loss have salutary effects on diastolic function. Therefore, we assessed the effects of yearlong CR (n = 12) and Ex (n = 13) interventions, which induced approximately 12% weight loss, on diastolic function in healthy, nonobese (body mass index = 23.5-29.9 kg/m2) men and women aged 50 to 60 yr. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (P < 0.05). Septal peak early mitral annular velocity (E') increased (P < 0.01) and peak E-wave velocity/E' decreased (P < 0.05) after weight loss in the CR group. Based on the PDF-derived indexes, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (chi'o), peak force (k'chi'o), and peak stored strain energy (1/2k'chi'o2). In the Ex group, k was unchanged, although septal chi'o and 1/2k'chi'o2 increased significantly and k'chi'o (P = 0.13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function.
authors.affiliation: Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Matt M
authors.initials: MM
authors.lastname: Riordan
authors.forename: Edward P
authors.initials: EP
authors.lastname: Weiss
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Meyer
authors.forename: Ali A
authors.initials: AA
authors.lastname: Ehsani
authors.forename: Susan B
authors.initials: SB
authors.lastname: Racette
authors.forename: Dennis T
authors.initials: DT
authors.lastname: Villareal
authors.forename: Luigi
authors.initials: L
authors.lastname: Fontana
authors.forename: John O
authors.initials: JO
authors.lastname: Holloszy
authors.forename: Sándor J
authors.initials: SJ
authors.lastname: Kovács
mesh_terms: D000886:Anthropometry; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D015150:Echocardiography, Doppler; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*