title: Cycloartane-type triterpenoids from the resinous exudates of Commiphora opobalsamum.
abstract: Eight new cycloartane-type triterpenoids, cycloartan-24-ene-1alpha,2alpha,3alpha-triol (1), 3beta-acetoxycycloartan-24-ene-1alpha,2alpha-diol (2), 1alpha-acetoxycycloartan-24-ene-2alpha,3beta-diol (3), 3beta-isovaleroyloxycycloartan-24-ene-1alpha,2alpha-diol (4), cycloartan-24-ene-1alpha,3beta-diol (5), cycloartan-23 E-ene-1alpha,2alpha,3beta,25-tetrol (6), and an epimeric mixture of 24 R,25-epoxycycloartane-1alpha,2alpha,3beta-triol (7) and 24 S,25-epoxycycloartane-1alpha,2alpha,3beta-triol (8), together with one known compound, cycloartan-24-ene-1alpha,2alpha,3beta-triol (9), were isolated from the resinous exudates of Commiphora opobalsamum. Their structures were established on the basis of mass spectrometry and multidimensional NMR spectroscopy. The cytotoxicity of compounds 1-9 was evaluated against the PC3 and DU145 human prostate tumor cell lines. All of the compounds except 1 and 5 exhibited moderate cytotoxicity against PC3 or DU145 cells with IC50 values ranging from 10.1 to 37.2 microM.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Wen-Zhu
authors.initials: WZ
authors.lastname: Wan
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Wang
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029744:Commiphora / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D053147:Plant Exudates / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D053147:Plant Exudates; D014315:Triterpenes; C085352:cycloartane