Influence of prednisolone on urinary calcium oxalate and struvite relative supersaturation in healthy young adult female domestic shorthaired cats.
Prednisolone (10 mg PO q24h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received prednisolone, 24-hour urine pH was lower and 24-hour urine excretion of creatinine, magnesium, phosphate, and potassium was higher than when cats received placebo. No significant difference was found in urinary relative supersaturation for calcium oxalate (CaOx) or struvite between treatment groups. Prednisolone administration did not induce diuresis, nor was it associated with increased calcium excretion or urinary saturation for CaOx in these healthy cats. Results of this study, however, should not be extrapolated to cats that form CaOx uroliths associated with idiopathic hypercalcemia.
Geyer
Nicole
N
Department of Small Animal Clinical Sciences, The University of Tennessee, Knoxville 37996-4544, USA.
Bartges
Joseph W
JW
Kirk
Claudia A
CA
Cox
Sherry
S
Hezel
Alisha
A
Moyers
Tammy
T
Hayes
Jimmy
J
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002129:Calcium Oxalate / Q000097:blood / Q000652:urine*; D002371:Cat Diseases / Q000652:urine; D002415:Cats / Q000652:urine*; D018592:Cross-Over Studies; D005260:Female; D017616:Magnesium Compounds / Q000652:urine*; D010710:Phosphates / Q000652:urine*; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D000069877:Struvite; D016896:Treatment Outcome; D016482:Urinalysis / Q000662:veterinary; D014545:Urinary Calculi / Q000652:urine / Q000662:veterinary
D000893:Anti-Inflammatory Agents; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D011239:Prednisolone; D000069877:Struvite