title: Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of Sedum sarmentosum extract.
abstract: This study aimed to assess some novel pharmacological activities of Sedum sarmentosum Bunge, a perennial herb widely distributed on the mountain slopes in Oriental countries and traditionally used for the treatment of certain inflammatory diseases. Sedum sarmentosum was extracted with absolute methanol to generate the methanol extract (SS). SS exhibited a significant inhibitory activity in the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner (IC(50)=2.29 microg/egg). The anti-nociceptive activity of SS was demonstrated using acetic acid-induced writhing model in mice. SS reduced the levels of anti-inflammatory markers, such as volume of exudates, number of polymorphonuclear leukocytes and nitrite content, in the air pouch model. It dose-dependently exhibited an inhibitory activity in the acetic acid-induced vascular permeability in mice. It suppressed production of nitric oxide in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages. In brief, the results provide some pharmacological basis for the therapeutic use of Sedum sarmentosum.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Jung
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kang
authors.forename: Yun Seon
authors.initials: YS
authors.lastname: Song
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
authors.forename: Young-Myeong
authors.initials: YM
authors.lastname: Kim
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031963:Sedum
chemical_list: D000700:Analgesics; D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D052247:Nitric Oxide Synthase Type II