title: [Abdominal obesity, insulin resistance, and the risk of colonic adenoma].
abstract: OBJECTIVE
  Abdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis. We conducted a prospective case controlled study for the evaluation of relationship between abdominal obesity, insulin resistance, and colorectal adenoma.
  
  
  METHODS
  Fifty patients with colorectal adenoma and fifty healthy subjects were included in this study. Total colonoscopic examinations were performed in all the subjects. Fasting blood sugar (FBS), insulin, homeostasis model assessment (HOMA-IR), triglyceride (TG), cholesterol (CROL), BMI (body mass index), WHR (waist hip ratio), percent body fat (PBF) and obesity degree (OD) were measured. HOMA-IR was considered to represent insulin resistance. Diabetic patients were excluded from this study.
  
  
  RESULTS
  There were no differences in sex, serum insulin, FBS, HOMA-IR, TG, CROL between adenoma and control group. Subjects with high BMI, WHR, percent body fat, and obesity were more likely to have colonic adenoma. Multiple logistic regression analysis after adjusting confounding factors, had revealed that WHR was the most important independent risk factor for colon adenoma.
  
  
  CONCLUSIONS
  Abdominal obesity was most closely related to colonic adenoma. However, insulin resistance was not related to colonic adenoma. A larger case controlled study is needed.
authors.affiliation: Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea. alwayshang@hanyang.ac.kr
authors.forename: Hang Lak
authors.initials: HL
authors.lastname: Lee
authors.forename: Byoung Kwan
authors.initials: BK
authors.lastname: Son
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Lee
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Jeon
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Sohn
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Yoon
authors.forename: Ho Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Hahm
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Dong Hoo
authors.initials: DH
authors.lastname: Lee
authors.forename: Chun Suk
authors.initials: CS
authors.lastname: Kee
mesh_terms: D050153:Abdominal Fat; D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors; D049629:Waist-Hip Ratio