Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis.
Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.
Dean
J P
JP
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nelson
P S
PS
D000375:Aging / Q000235:genetics* / Q000473:pathology / Q000502:physiology*; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D016922:Cellular Senescence / Q000235:genetics* / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008954:Models, Biological; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology