Investigation of a flexible enantiospecific approach to aziridines.
A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups.
Jamookeeah
Clare E
CE
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, United Kingdom.
Beadle
Christopher D
CD
Jackson
Richard F W
RF
Harrity
Joseph P A
JP
D000478:Alkylation; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D001388:Aziridines; D003300:Copper