NetworkBLAST: comparative analysis of protein networks.
The identification of protein complexes is a fundamental challenge in interpreting protein-protein interaction data. Cross-species analysis allows coping with the high levels of noise that are typical to these data. The NetworkBLAST web-server provides a platform for identifying protein complexes in protein-protein interaction networks. It can analyze a single network or two networks from different species. In the latter case, NetworkBLAST outputs a set of putative complexes that are evolutionarily conserved across the two networks.


BACKGROUND
NetworkBLAST is available as web-server at: www.cs.tau.ac.il/~roded/networkblast.htm.
Kalaev
Maxim
M
School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel. kalaevma@post.tau.ac.il
Smoot
Mike
M
Ideker
Trey
T
Sharan
Roded
R
D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D020407:Internet; D025941:Protein Interaction Mapping / Q000379:methods*; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D013997:Time Factors
D029721:Drosophila Proteins; D029701:Saccharomyces cerevisiae Proteins