title: G-CSF-induced remission in two cases of acute myeloid leukemia.
abstract: We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.
authors.affiliation: Department of Hematology, University Hospital Zurich, Rämistrasse 100, 8091 Zürich, Switzerland. rudolf.benz@usz.ch
authors.forename: Rudolf
authors.initials: R
authors.lastname: Benz
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: Goede
authors.forename: Valérie
authors.initials: V
authors.lastname: Parlier
authors.forename: Dominique
authors.initials: D
authors.lastname: Mühlematter
authors.forename: Martine
authors.initials: M
authors.lastname: Jotterand
authors.forename: Jörg
authors.initials: J
authors.lastname: Fehr
mesh_terms: D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D016179:Granulocyte Colony-Stimulating Factor