De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy.
Immune reconstitution inflammatory syndrome is typically seen in human immunodeficiency virus-seropositive patients who commence antiretroviral therapy. In patients who experience this syndrome, the immune system's reconstitution leads to a response directed against pathogens or autoantigens. We report, to our knowledge, the first case of autoimmune hepatitis caused by immune reconstitution.
O'Leary
Jacqueline G
JG
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Zachary
Kimon
K
Misdraji
Joseph
J
Chung
Raymond T
RT
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D019693:Hepatitis, Autoimmune / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology* / Q000821:virology