title: Nogo receptor antagonizes p75NTR-dependent motor neuron death.
abstract: The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F-67085 France.
authors.forename: Luc
authors.initials: L
authors.lastname: Dupuis
authors.forename: Mariana
authors.initials: M
authors.lastname: Pehar
authors.forename: Patricia
authors.initials: P
authors.lastname: Cassina
authors.forename: Frédérique
authors.initials: F
authors.lastname: Rene
authors.forename: Raquel
authors.initials: R
authors.lastname: Castellanos
authors.forename: Caroline
authors.initials: C
authors.lastname: Rouaux
authors.forename: Mandi
authors.initials: M
authors.lastname: Gandelman
authors.forename: Leda
authors.initials: L
authors.lastname: Dimou
authors.forename: Martin E
authors.initials: ME
authors.lastname: Schwab
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Loeffler
authors.forename: Luis
authors.initials: L
authors.lastname: Barbeito
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Gonzalez de Aguilar
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D016923:Cell Death; D058851:GPI-Linked Proteins; D005786:Gene Expression Regulation; D051379:Mice; D009046:Motor Neurons / Q000378:metabolism; D009185:Myelin Proteins / Q000378:metabolism / Q000502:physiology*; D009410:Nerve Degeneration / Q000378:metabolism*; D020932:Nerve Growth Factor / Q000378:metabolism; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism; D000070816:Nogo Receptor 1; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology*; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism*
chemical_list: D058851:GPI-Linked Proteins; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor; C419790:Rtn4r protein, mouse; C486581:Rtn4r protein, rat; C517634:Ngfr protein, mouse; C068313:Ngfr protein, rat; D020932:Nerve Growth Factor