title: Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very-low-birthweight infants.
abstract: This study examined the developmental and clinical outcomes in very-low-birthweight (VLBW; < or =1500g) infants with and without bronchopulmonary dysplasia (BPD) throughout infancy, and assessed if BPD predicted poor developmental outcome beyond the effects of other risk factors. One hundred and three VLBW infants (53 males, 50 females; mean gestational age 28wks [SD 2] birthweight 1041g [SD 261]) were graded for severity of BPD according to the American National Institutes of Health (NIH) consensus definition. Neuro-development was assessed using the Neonatal Neurobehavioral Examination-Chinese version, at 36 and 39 weeks' postmenstrual age, and the 2nd edition of the Bayley Scales of Infant Development at 6 and 12 months' corrected age. Clinical outcome was measured by means of rehospitalization for pulmonary causes and treatment with pulmonary medications. Compared with infants without BPD, infants with BPD had higher rates of clinical morbidity, and those with severe BPD further exhibited higher incidences of developmental delay throughout infancy. BPD predicts poor 1-year developmental and clinical outcomes in VLBW infants for which effects are well correlated to the NIH consensus definition.
authors.affiliation: School of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Suh-Fang
authors.initials: SF
authors.lastname: Jeng
authors.forename: Chyong-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Po-Nien
authors.initials: PN
authors.lastname: Tsao
authors.forename: Hung-Chieh
authors.initials: HC
authors.lastname: Chou
authors.forename: Wang-Tso
authors.initials: WT
authors.lastname: Lee
authors.forename: Hsin-An
authors.initials: HA
authors.lastname: Kao
authors.forename: Han-Yang
authors.initials: HY
authors.lastname: Hung
authors.forename: Jui-Hsing
authors.initials: JH
authors.lastname: Chang
authors.forename: Nan-Chang
authors.initials: NC
authors.lastname: Chiu
authors.forename: Wu-Shiun
authors.initials: WS
authors.lastname: Hsieh
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index