Template switching: from replication fork repair to genome rearrangements.
Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.
Branzei
Dana
D
FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy. dana.branzei@ifom-ieo-campus.it
Foiani
Marco
M
D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics; D017353:Gene Deletion; D018628:Gene Dosage; D020440:Gene Duplication; D015964:Gene Expression Regulation, Bacterial; D015321:Gene Rearrangement; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D018991:Myelin Proteolipid Protein / Q000235:genetics*; D009690:Nucleic Acid Conformation; D020371:Pelizaeus-Merzbacher Disease / Q000235:genetics*; D011995:Recombination, Genetic; D020080:Tandem Repeat Sequences; D013698:Templates, Genetic
D008565:Membrane Proteins; D018991:Myelin Proteolipid Protein; C472930:PLP1 protein, human