title: Changes in oral health-related quality of life during fixed orthodontic appliance therapy.
abstract: BACKGROUND
  Our objective was to determine changes in oral health-related quality of life (OHRQoL) during fixed orthodontic appliance therapy.
  
  
  METHODS
  This prospective cohort study included a consecutive sample of 217 children receiving fixed orthodontic appliance therapy. Each subject completed the 37-item child perception questionnaire (CPQ) at 5 times: before treatment (T0), and after the placement of the fixed appliance at 1 week (T1), 1 month (T2), 3 months (T3), and 6 months (T4).
  
  
  RESULTS
  The response rate was 91% (198 of 217). There were significant changes in overall CPQ scores (P <.001), oral symptom scores (P <.001), functional limitation scores (P <.001), and emotional well-being scores (P <.001) over the study period (6 months). There were significant differences in certain CPQ domain scores at T1, T2, T3, and T4 compared with T0 (P <.05) and consistently with respect to oral symptoms. Significant changes in certain CPQ domain scores also occurred between T1 and T2 (P <.05) and between T2 and T3 (P <.05). However, there were no significant changes in social well-being scores (P >.05).
  
  
  CONCLUSIONS
  Changes in OHRQoL occur after fixed orthodontic appliance therapy. Compared with pretreatment, a patient's OHRQoL is frequently worse during treatment (oral symptoms, functional limitations), although it is better in some aspects (emotional well-being). The period of greatest change in OHRQoL occurs during the first month of treatment.
authors.affiliation: Department of Orthodontics and Key Lab for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan, China.
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.forename: Colman
authors.initials: C
authors.lastname: McGrath
authors.forename: Urban
authors.initials: U
authors.lastname: Hägg
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008310:Malocclusion / Q000523:psychology / Q000628:therapy; D009909:Oral Health; D009967:Orthodontic Appliances; D009971:Orthodontics, Corrective / Q000295:instrumentation* / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013997:Time Factors