title: Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03).
abstract: OBJECTIVE
  The aim of this study was to prospectively assess the quality of life (QOL) of patients treated by concomitant chemo radiation for locally advanced anal canal carcinoma.
  
  
  METHODS
  We report on a subgroup of 119 patients enrolled in a 306-patient therapeutic intensification prospective trial (ACCORD 03). This trial evaluated the impact on colostomy-free survival of induction chemotherapy and/or high dose radiotherapy (factorial design 2 *2 treatment arms). QOL was assessed both before and 2 months after treatment using the EORTC QLQ-C30 questionnaire as well as a questionnaire relating to anal sphincter conservative treatment (AS-CT).
  
  
  RESULTS
  Compared to pre-treatment scores, patients reported significant improvement in their emotional function (+8.4 points p=0.002), global health status (+5.9 points p=0.0007), as well as a decrease in insomnia (-13.8 points p<0.0001), constipation (-12.0 points p<0.0001), appetite loss (-10.3 points p<0.0001) and pain (-9.6 points p=0.0002). The AS-CT degree of satisfaction with intestinal functions score was increased (+11.2 points p<0.0001).
  
  
  CONCLUSIONS
  This is the first prospective study comparing QOL of patients with advanced anal canal carcinoma, before and 2 months after conservative treatment. Two months after treatment, QOL was improved. Induction chemotherapy and/or high dose radiotherapy did not provide a negative impact on QOL.
authors.affiliation: Department of Radiation Oncology and Brachytherapy, Centre Alexis Vautrin, Vandoeuvre les Nancy, France. l.tournier@nancy.fnclcc.fr
authors.forename: Laetitia
authors.initials: L
authors.lastname: Tournier-Rangeard
authors.forename: Mariette
authors.initials: M
authors.lastname: Mercier
authors.forename: Didier
authors.initials: D
authors.lastname: Peiffert
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gerard
authors.forename: Pascale
authors.initials: P
authors.lastname: Romestaing
authors.forename: Claire
authors.initials: C
authors.lastname: Lemanski
authors.forename: Xavier
authors.initials: X
authors.lastname: Mirabel
authors.forename: Pascal
authors.initials: P
authors.lastname: Pommier
authors.forename: Bernard
authors.initials: B
authors.lastname: Denis
mesh_terms: D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010388:Pelvis / Q000528:radiation effects; D011788:Quality of Life; D011795:Surveys and Questionnaires