title: Novel abietane diterpenoids and aromatic compounds from Cladonia rangiferina and their antimicrobial activity against antibiotics resistant bacteria.
abstract: From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. yosikawa@ph.bunri-u.ac.jp
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Kokudo
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Nakano
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shibata
authors.forename: Naokatsu
authors.initials: N
authors.lastname: Aragaki
authors.forename: Tomihiko
authors.initials: T
authors.lastname: Higuchi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry; D016983:Enterococcus / Q000187:drug effects*; D007564:Japan; D008011:Lichens / Q000737:chemistry*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
chemical_list: D045784:Abietanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; C525766:hanagokenol A; C525767:hanagokenol B; C501333:sugiol