title: Bioaccessibility of selected trace metals in urban PM2.5 and PM10 samples: a model study.
abstract: Bioaccessibility of trace metals originating from urban particulate matter was assessed in a worst case scenario to evaluate the uptake and thus the hazardous potential of these metals via gastric juice. Sampling was performed over a period of about two months at the Getreidemarkt in downtown Vienna. Concentrations of the assayed trace metals (Ti, Cr, Mn, Co, Ni, Cu, Zn, Mo, Ag, Cd, Sn, Sb, Tl and Pb) were determined in PM2.5 and PM10 samples by ICP-MS. The metal concentrations in sampled air were in the low picogram to high nanogram per cubic metre range. The concentrations in PM2.5 samples were generally lower than those in PM10 samples. The average daily intake of these metals by inhalation for a healthy adult was estimated to be in the range of <1 ng (Tl) to >1,000 ng (Zn). To estimate the accessibility of the inhaled and subsequently ingested metals (i.e. after lung clearance had taken place) in the size range from 2.5- to 10-microm aerodynamic equivalent diameter, a batch-extraction with synthetic gastric juice was performed. The data were used to calculate the bioaccessibility of the investigated trace metals. Extractable fractions ranged from 2.10% (Ti in PM2.5) to 91.0% (Cd in PM2.5), thus yielding bioaccessible fractions (PM(2.5-10)) from 0.16 ng (Ag) to 178 ng (Cu).
authors.affiliation: Division of Analytical Chemistry, University of Natural Resources and Applied Life Sciences-Vienna, Muthgasse 18, 1190, Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Falta
authors.forename: Andreas
authors.initials: A
authors.lastname: Limbeck
authors.forename: Gunda
authors.initials: G
authors.lastname: Koellensperger
authors.forename: Stephan
authors.initials: S
authors.lastname: Hann
mesh_terms: D000336:Aerosols; D000393:Air Pollutants / Q000378:metabolism*; D005744:Gastric Acid / Q000378:metabolism; D019570:Inhalation Exposure; D013058:Mass Spectrometry / Q000379:methods*; D008670:Metals / Q000378:metabolism*; D008958:Models, Molecular; D010316:Particle Size; D012119:Respiration; D012680:Sensitivity and Specificity; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D008670:Metals; D014131:Trace Elements