Antidiabetic properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from mulberry (Morus bombycis koidzumi) root in streptozotocin-induced diabetic rats.
We investigated the antidiabetic properties of 2,5-dihydroxy-4,3-di(beta-D-glucopyranosyloxy)-trans-stilbene (DGTS) isolated from Morus bombycis Koidzumi in streptozotocin (STZ)-induced diabetic rats. The DGTS prevented the increase in aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen levels in serum of diabetic rats. At doses of 200-800 mg/kg, DGTS improved hyperglycemia in the rats, and the hypoglycemic effect of DGTS was comparable to that of tolbutamide. The histological observations showed that DGTS prevented atrophy of pancreatic beta-cells and vascular degenerative changes in the islets. DGTS reversed STZ-induced diabetes and had antioxidant activity in assays of FeCl(2)/ascorbic acid-induced lipid peroxidation in the rats. Levels of cytochrome P450 2E1 mRNA, as measured by reverse transcription-polymerase chain reaction, were lower in the livers of the DGTS-treated rats than those of the control group. These results suggest that DGTS might be beneficial in the treatment of type 1 diabetes.
Heo
Seong-Il
SI
School of Biotechnology, Kangwon National University, Chuncheon, Republic of Korea.
Jin
Ying-Shan
YS
Jung
Mee Jung
MJ
Wang
Myeong-Hyeon
MH
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D031625:Morus / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000627:therapeutic use*
C515095:2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013267:Stilbenes; D019392:Cytochrome P-450 CYP2E1