title: [The usefulness of plasma cystatin C determination as a marker of glomerular filtration rate].
abstract: Cystatin C is a low molecular weight protein; a cysteine proteinase inhibitor. As it is freely filtrated in the renal glomeruli, and not reabsorbed into circulation, therefore it may be used as a marker of glomerular filtration rate (GFR). We discuss clinical studies which were focused on the feasibility of plasma Cys C determination as a marker of GFR in various populations. Many of these studies suggest that plasma Cys C may be superior to plasma creatinine for the detection of patients with early decline in renal function. Recent data indicate, that Cys C may be a risk marker or factor of death or cardiovascular event in high-risk populations.
authors.affiliation: Katedra i Klinika Chorób Wewnetrznych, Nadciśnienia Tetniczego i Angiologii Akademii Medycznej w Warszawie. bsymonid@amwaw.edu.pl
authors.forename: Bartosz
authors.initials: B
authors.lastname: Symonides
authors.forename: Maria
authors.initials: M
authors.lastname: Wieteska
authors.forename: Dagna
authors.initials: D
authors.lastname: Bobilewicz
mesh_terms: D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015201:Meta-Analysis as Topic
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine