title: The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
abstract: The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.
authors.affiliation: Neurogen Corporation, 35 North East Industrial Road, Branford, CT 06405, USA.
authors.forename: Taeyoung
authors.initials: T
authors.lastname: Yoon
authors.forename: Stéphane
authors.initials: S
authors.lastname: De Lombaert
authors.forename: Robbin
authors.initials: R
authors.lastname: Brodbeck
authors.forename: Michael
authors.initials: M
authors.lastname: Gulianello
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Chandrasekhar
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Horvath
authors.forename: Ping
authors.initials: P
authors.lastname: Ge
authors.forename: Mark T
authors.initials: MT
authors.lastname: Kershaw
authors.forename: James E
authors.initials: JE
authors.lastname: Krause
authors.forename: John
authors.initials: J
authors.lastname: Kehne
authors.forename: Diane
authors.initials: D
authors.lastname: Hoffman
authors.forename: Darío
authors.initials: D
authors.lastname: Doller
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Hodgetts
mesh_terms: D001007:Anxiety / Q000188:drug therapy; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D003863:Depression / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D000099052:CRF Receptor, Type 1
chemical_list: D007546:Isoquinolines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1