Around-the-clock, rapid diagnosis of influenza by means of membrane chromatography antigen testing confirmed by polymerase chain reaction.
One rapid membrane chromatography test and 2 immunofluorescence tests were compared with polymerase chain reaction as tools for the diagnosis of influenza in 277 patients treated in an emergency department. The sensitivity on days 1-3 of symptoms was 71% for the rapid membrane chromatography test, 70% for the first immunofluorescence test, and 79% for the second immunofluorescence test. Rapid tests are useful for round-the-clock identification of influenza, with follow-up polymerase chain reaction used for confirmation.
Nilsson
Anna C
AC
Department of Clinical Sciences, Malmö Infectious Disease Research Unit, Malmö University Hospital, Lund University, Malmö, Sweden.
Alemo
Birgitta
B
Björkman
Per
P
Dillner
Lena
L
Melhus
Asa
A
Nilsson
Berit
B
Widell
Anders
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000032:analysis*; D002845:Chromatography / Q000295:instrumentation*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques / Q000295:instrumentation / Q000379:methods*; D007251:Influenza, Human / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000821:virology; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D010614:Pharynx / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods*
D000956:Antigens, Viral