title: DR negativity is a distinctive feature of M1/M2 AML cases with NPM1 mutation.
abstract: Our previous observation of a higher incidence of FLT3-ITD in DR(-) M1/M2 AML than in DR(+) M1/M2 led to an investigation of NPM1 mutation in the same samples, since DR(-) AML and AML with NPM1 mutation share such characteristics as normal karyotype, the absence of CD34, and FLT3-ITD. NPM1 mutation was found in 18 of 26 (69.2%) of DR(-) cases, but not in any of 28 DR(+) cases. FLT3-ITD was noted in 66.7% of the cases with NPM1 mutation. These findings point to DR negativity as another phenotypic feature of AML with NPM1 mutation.
authors.affiliation: International Center for Medical Research and Treatment (ICMRT), Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan.
authors.forename: Meilani
authors.initials: M
authors.lastname: Syampurnawati
authors.forename: Eiji
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Bambang
authors.initials: B
authors.lastname: Ardianto
authors.forename: Mariko
authors.initials: M
authors.lastname: Takenokuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakamachi
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Kumagai
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Saigo
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Matsui
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nagai
authors.lastname: Gunadi
authors.forename: Hisahide
authors.initials: H
authors.lastname: Nishio
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yabe
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Kondo
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D001483:Base Sequence; D018076:DNA, Complementary; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology; D000090243:Nucleophosmin; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018076:DNA, Complementary; D006684:HLA-DR Antigens; C000716967:NPM1 protein, human; D000090243:Nucleophosmin