Medullomyoblastoma with calcification: a case report.
Medulloblastoma containing a striated muscle component is a rare embryonal cerebellar neoplasm, designated as medullomyoblastoma. We report here a case of medullomyoblastoma in a 9-year-old boy who developed signs of increased intracranial pressure and truncal ataxia. MRI disclosed a well-defined, egg-sized mass with heterogenous intermediate signal intensity in the cerebellar vermis, which compressed the 4th ventricle. The resected tumor consisted of hyperchromatic, undifferentiated neuroectodermal cells and desmin-positive myogenic cells with striation, compatible with medullomyoblastoma. MIB labeling index was 8% in undifferentiated cells but no labeling was seen in the myogenic cells. In addition, there were areas of calcification and psammoma bodies, which was a rare finding in this tumor.
Chaturvedi
Sujata
S
Department of Pathology, Institute of Human Behavior and Allied Sciences, Delhi, India. cvsujata@hotmail.com
Gupta
Sanjeev
S
Singhal
Shweta
S
Kumari
Rima
R
D002114:Calcinosis / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D014057:Tomography, X-Ray Computed