title: Developmental regulation of gene expression in trypanosomatid parasitic protozoa.
abstract: Kinetoplastids branched early from the eukaryotic lineage and include several parasitic protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into polycistronic RNAs and individual mRNAs are resolved by coupled co-transcriptional trans-splicing of a universal splice-leader RNA (SL-RNA) and 3'-end maturation processes. Protein-coding genes lack RNA polymerase II promoters. Consequently, most of gene regulation in these organisms occurs post-transcriptionally. Over the last few years, many more genes that are regulated at the mRNA stability level and a few at the translation level have been reported. Almost all major trypanosome homologues of yeast/mammalian mRNA degradation enzymes have been functionally characterized and major pathways identified. Novel paradigms have also recently emerged: regulated post-transcriptional processing of cytoplasmic RNAs, SL-RNA transcriptional silencing-mediated global stress response, and Leishmania-specific large-scale modulation of post-transcriptional gene expression via inactive degenerated retroelements. Several of these developments have greatly benefited from the recently completed genomic sequences and functional genomic studies.
authors.affiliation: Research Centre in Infectious Diseases, CHUL Research Centre of Laval University, CHUQ, 2705 Laurier Blvd., Quebec, QC, Canada G1V 4G2.
authors.forename: Simon
authors.initials: S
authors.lastname: Haile
authors.forename: Barbara
authors.initials: B
authors.lastname: Papadopoulou
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016053:RNA, Protozoan / Q000235:genetics / Q000378:metabolism; D014351:Trypanosomatina / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins; D012333:RNA, Messenger; D016053:RNA, Protozoan