[Cytomegalovirus disease in HIV-1 infected Chilean children].
Cytomegalovirus (CMV) is a frequent opportunistic infection in human immunodeficiency virus type 1 (HIV-1) infected children associated with significant morbidity and mortality. The aim of this study was to determine the frequency and impact of CMV disease in a prospective ly followed cohort of HIV-1 infected Chilean children. CMV disease was diagnosed in 28 out of 222 HIV infected children (12.6%); 92% of them were classified in category C and 61% in category 3 (CDC, 1994). Lung disease was the most common manifestation (25 children). Samples were obtained from the respiratory tract, blood, urine and tissue biopsies. Shell vial for CMV early antigen detection was the most commonly used diagnostic technique (20/ 28). All patients were treated with iv.ganciclovir and two children died during the CMV episode. The mean survival time for the remaining children is currently 42 months.


CONCLUSIONS
CMV disease was frequent and caused mortality in HIV-1 infected Chilean children. Early diagnosis and treatment are key for clinical success.
Peña
Anamaría
A
Hospital Dr. Sótero del Río, Pontificia Universidad Católica de Chile, Santiago, Chile.
Larrañaga
Carmen
C
Luchsinger
Vivian
V
Villarroel
Julia
J
Chávez
Ana
A
Wu
Elba
E
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015774:Ganciclovir / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D016019:Survival Analysis
D000998:Antiviral Agents; D015774:Ganciclovir