Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest.
Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC 50 values ranging from 0.19 to 0.63 microM.
Murphy
Brian T
BT
Department of Chemistry, Virginia Polythecnic Institute, Blasburg, Virginia, USA.
Brodie
Peggie
P
Slebodnick
Carla
C
Miller
James S
JS
Birkinshaw
Chris
C
Randrianjanaka
Lucien M
LM
Andriantsiferana
Rabodo
R
Rasamison
Vincent E
VE
TenDyke
Karen
K
Suh
Edward M
EM
Kingston
David G I
DG
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008270:Madagascar; D008968:Molecular Conformation; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; C528677:malleastrone A; C528678:malleastrone B; C528679:malleastrone C