Botryolides A-E, decarestrictine analogues from a fungicolous Botryotrichum sp. (NRRL 38180).
Four new decarestrictine analogues (botryolides A-D; 1- 4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D ( 6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1- 5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.
Sy
Arlene A
AA
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Swenson
Dale C
DC
Gloer
James B
JB
Wicklow
Donald T
DT
D001231:Aspergillus flavus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D005431:Florida; D005658:Fungi / Q000737:chemistry*; D005670:Fusarium / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013241:Sterigmatocystin / Q000737:chemistry / Q000302:isolation & purification
D007783:Lactones; D013241:Sterigmatocystin; C073577:decarestrictine D