Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosulfate.
A 35-year-old morbidly obese woman on home haemodialysis presented with painful indurated subcutaneous nodules histologically characteristic of calciphylaxis. After failing to respond to conventional treatment, she was commenced on an intravenous infusion of 25 g of sodium thiosulfate three times per week. Two weeks after commencing sodium thiosulfate, the pain resolved completely. By 12 weeks, the lesions had healed and the infusions were ceased. Two months later, skin lesions recurred, but resolved again within 3 months of recommencement of sodium thiosulfate treatment, which was continued for 8 months. The treatment was well tolerated. There has been no recurrence of lesions in the 18 months since the cessation of sodium thiosulfate. Clinical trials to determine the optimum dose and duration of therapy for sodium thiosulfate treatment of calciphylaxis should be given priority because of its high rate of success in treating what is otherwise a severe and mostly lethal condition.
Subramaniam
Kavitha
K
Department of Nephrology and Renal Transplantation, Royal Perth Hospital, Perth, WA, Australia. kavitha.subramaniam@health.wa.gov.au
Wallace
Hilary
H
Sinniah
Rajalingam
R
Saker
Barry
B
D000975:Antioxidants / Q000008:administration & dosage*; D002115:Calciphylaxis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002614:Chelating Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D012008:Recurrence; D006435:Renal Dialysis; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013885:Thiosulfates / Q000008:administration & dosage*; D014652:Vascular Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D000975:Antioxidants; D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate