title: A case of more abundant and dysplastic adenomas in the interposed colon than in the native colon.
abstract: We report a 60-year-old woman with intramucosal adenocarcinoma arising in the interposed colon, 40 years after the esophageal reconstruction for lye induced esophageal stricture. Although synchronous adenomas were also found in the native colon where the graft was taken, the number of adenomas was greater in the interposed colon and more dysplastic, even progressed to adenocarcinoma, than that of the native colon. The microsatellite instability-testing performed in the intramucosal carcinoma from interposed colon showed absence of microsatellite instability. Changing of location and functional demand of colonic segment, and the exposure to different intraluminal contents might have facilitated the adenoma- carcinoma transformation in the interposed colon.
authors.affiliation: Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Hwang
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Youn
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kwon
authors.forename: Hoguen
authors.initials: H
authors.lastname: Kim
authors.forename: Jae Bock
authors.initials: JB
authors.lastname: Chung
authors.forename: Yong Chan
authors.initials: YC
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000236:Adenoma / Q000209:etiology / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology*; D018450:Disease Progression; D004944:Esophagoplasty / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D013997:Time Factors