title: [Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats].
abstract: OBJECTIVE
  To determine the changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats of chronic epilepsy induced by pentylenetetrazole (PTZ).
  
  
  METHODS
  Sixty rats were randomly divided into a control group and a PTZ group (PTZ 30 mg/kg, intraperitoneal injection, once daily). The changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats were examined by Timm staining.
  
  
  RESULTS
  Before the occurrence of convulsion confirmed by behavior and EEG, the mossy fiber sprouting was found in the PTZ group. The grade of the mossy fiber sprouting increased with the gradual establishment of kindling effect.
  
  
  CONCLUSIONS
  Mossy fiber sprouting may play an important role in the onset and development of epilepsy.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. tianff@sina.com
authors.forename: Fa-fa
authors.initials: FF
authors.lastname: Tian
authors.forename: Ting-hui
authors.initials: TH
authors.lastname: Guo
authors.forename: Jin-mei
authors.initials: JM
authors.lastname: Chen
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Ma
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Cai
authors.forename: Feng-hong
authors.initials: FH
authors.lastname: Yao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D019599:Mossy Fibers, Hippocampal / Q000254:growth & development*; D009474:Neurons / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010433:Pentylenetetrazole