title: Synthesis, cardiostimulatory, and cardioinhibitory effects of selected insect peptides on Tenebrio molitor.
abstract: The subject of these studies was a search for proctolin antagonists among peptides originating from insect species because the proctolin antagonists constantly pose a problem. During these studies we performed the synthesis of the following peptides: a native decapeptide from Manduca sexta Mas-MT-I and its 11 analogs with shortened sequences at the N-end as well as a growth suppressor, a pentapeptide isolated from Antheraea yamamai, Any-GS and its 10 analogs, modified at position 1 and with a shortened peptide chain. Biological effects were evaluated by the cardiotropic test on the semi-isolated heart of the insect species Tenebrio molitor. Mas-MT-I and six analogs stimulate the heartbeat frequency, especially [6-10]-Mas-MT-I, whereas the [4-10]-Mas-MT-I analog shows a strong inhibition of the heartbeat frequency, if insect. The Any-GS and the analogs [Gln(1)]- and [Gly(1)]-Any-GS also show a strong cardioinhibitory effect.
authors.affiliation: Faculty of Chemistry, University of Wrocław, Wrocław, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Szymanowska-Dziubasik
authors.forename: P
authors.initials: P
authors.lastname: Marciniak
authors.forename: G
authors.initials: G
authors.lastname: Rosiński
authors.forename: D
authors.initials: D
authors.lastname: Konopińska
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019476:Insect Proteins / Q000494:pharmacology*; D018402:Manduca / Q000737:chemistry*; D010455:Peptides / Q000494:pharmacology*; D013712:Tenebrio / Q000187:drug effects*
chemical_list: D019476:Insect Proteins; D010455:Peptides