title: Sensitive chiral analysis by CE: an update.
abstract: A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10(-10) M enabling enantiomer analysis in a variety of real samples including complex biological matrices.
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Sánchez-Hernández
authors.forename: Antonio Luis
authors.initials: AL
authors.lastname: Crego
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Marina
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Ruiz
mesh_terms: D000818:Animals; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000097:blood; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations