title: Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis.
abstract: Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.
authors.affiliation: Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan. ihisamit@med.teikyo-u.ac.jp
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Ide
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Hatake
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Terado
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsukino
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Okegawa
authors.forename: Kikuo
authors.initials: K
authors.lastname: Nutahara
authors.forename: Eiji
authors.initials: E
authors.lastname: Higashihara
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horie
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D001859:Bone Neoplasms / Q000556:secondary*; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D016173:Macrophage Colony-Stimulating Factor / Q000032:analysis / Q000037:antagonists & inhibitors / Q000097:blood* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D016173:Macrophage Colony-Stimulating Factor