Genotyping of Panamanian Trypanosoma cruzi stocks using the calmodulin 3'UTR polymorphisms.
Mutations in the 3' untranslated region of calmodulin gene have recently been reported to be specific to different Trypanosoma cruzi lineages. In the present report, this molecular marker was used to genotype 24 T. cruzi isolates from humans and vectors from different endemic areas in Panama. The finding of solely T. cruzi I genotype might explain the low morbidity of Chagas' disease in the region when compared to other countries in Latin America.
Brandao
Adeilton
A
Oswaldo Cruz Institute, Fiocruz, Rio de Janiero, Brazil.
Samudio
Franklyn
F
Fernandes
Octavio
O
Calzada
Jose E
JE
Sousa
Octavio E
OE
D020413:3' Untranslated Regions / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002147:Calmodulin / Q000235:genetics*; D017124:Conserved Sequence; D005838:Genotype; D010176:Panama; D011110:Polymorphism, Genetic; D015800:Protozoan Proteins / Q000235:genetics*; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014349:Trypanosoma cruzi / Q000235:genetics* / Q000302:isolation & purification
D020413:3' Untranslated Regions; D002147:Calmodulin; D015800:Protozoan Proteins