title: Randomized clinical trial evaluating elective laparoscopic appendicectomy for chronic right lower-quadrant pain.
abstract: BACKGROUND
  It is questionable whether elective appendicectomy can effectively reduce persistent or recurrent right lower-quadrant abdominal pain due to chronic or recurrent appendicitis.
  
  
  METHODS
  This single-centre double-blind randomized clinical trial studied the effects of elective laparoscopic appendicectomy on pain 6 months after operation in patients with persistent or recurrent lower-quadrant pain. A secondary outcome evaluated was the relationship between clinical response and appendiceal histopathology. The analysis was performed on an intention-to-treat basis.
  
  
  RESULTS
  Forty patients were randomized to laparoscopic appendicectomy (18) or laparoscopic inspection only (22). Postoperative pain scores differed significantly between the groups, favouring appendicectomy (P = 0.005). Relative risk calculations indicated that there was a 2.4 (95 per cent confidence interval (c.i.) 1.3 to 4.0) times greater chance of improvement in pain after laparoscopic appendicectomy. The number needed to treat was 2.2 (95 per cent c.i. 1.5 to 6.5). There was no association between postoperative pain scores and histopathology findings.
  
  
  CONCLUSIONS
  Persistent or recurrent lower abdominal pain can be treated by elective appendicectomy with significant pain reduction in properly selected cases. Histopathology may not be abnormal.
  
  
  BACKGROUND
  ISRCTN48831122 (http://www.controlled-trials.com).
authors.affiliation: Department of Surgery, Stichting Pathologische Anatomie en Medische Microbiologie, Máxima Medisch Centrum, Veldhoven, The Netherlands. r.roumen@mmc.nl
authors.forename: R M H
authors.initials: RM
authors.lastname: Roumen
authors.forename: R P R
authors.initials: RP
authors.lastname: Groenendijk
authors.forename: C E J
authors.initials: CE
authors.lastname: Sloots
authors.forename: K E S
authors.initials: KE
authors.lastname: Duthoi
authors.forename: M R M
authors.initials: MR
authors.lastname: Scheltinga
authors.forename: C M A
authors.initials: CM
authors.lastname: Bruijninckx
mesh_terms: D015746:Abdominal Pain / Q000209:etiology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000473:pathology / Q000601:surgery*; D002908:Chronic Disease; D004311:Double-Blind Method; D017558:Elective Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology; D012008:Recurrence; D016896:Treatment Outcome