title: Human papillomavirus infection in women with and without cervical cancer in Warsaw, Poland.
abstract: Cervical cancer incidence and mortality in Poland is among the highest in Europe. To investigate infection with different human papillomaviruses (HPV) in Warsaw, Poland, we obtained cervical cell specimens from 834 women aged 18-59 years from the general population, and 88 cervical cancers. DNA of 44 HPV types was detected using a GP5+/6+-based PCR assay. HPV prevalence was 16.6% in the general female population, being highest (24.2%) in women aged 25-34 years, notably among unmarried women (37.3%). HPV prevalence fell to 8.6% at ages 55-59. High-risk HPV prevalence was 11.3%, with HPV16 being the most common type (3.7%). All but one cervical cancer were high-risk HPV-positive, although the importance of HPV16 (73%) was much greater, and multiple infections fewer (1%), than among HPV-positive women in the general female population. In summary, we report a relatively high burden of HPV infection in Warsaw, Poland, where 79% of cervical cancers are theoretically preventable by HPV16/18 vaccines.
authors.affiliation: The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 5 W. K. Roentgena Street, 02-781 Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Bardin
authors.forename: S
authors.initials: S
authors.lastname: Vaccarella
authors.forename: G M
authors.initials: GM
authors.lastname: Clifford
authors.forename: J
authors.initials: J
authors.lastname: Lissowska
authors.forename: M
authors.initials: M
authors.lastname: Rekosz
authors.forename: P
authors.initials: P
authors.lastname: Bobkiewicz
authors.forename: J
authors.initials: J
authors.lastname: Kupryjańczyk
authors.forename: R
authors.initials: R
authors.lastname: Krynicki
authors.forename: J
authors.initials: J
authors.lastname: Jonska-Gmyrek
authors.forename: A
authors.initials: A
authors.lastname: Danska-Bidzinska
authors.forename: P J F
authors.initials: PJ
authors.lastname: Snijders
authors.forename: C J L M
authors.initials: CJ
authors.lastname: Meijer
authors.forename: W
authors.initials: W
authors.lastname: Zatonski
authors.forename: S
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D052685:Alphapapillomavirus / Q000302:isolation & purification; D005260:Female; D006801:Humans; D017533:Marital Status / Q000706:statistics & numerical data; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000453:epidemiology*; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology