title: In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds.
abstract: Pure hydroxyapatite (HAp) and a biphasic calcium phosphate [containing 90% of beta-tri-calcium phosphate (beta-TCP) and 10% HAp] were tailored through an aqueous solution combustion synthesis. Porous struts were prepared using all the powders along with bioglass, a known bioactive material, and subsequently characterized. Sterilized struts were implanted to the lateral side of radius bone of 24 black Bengal goats of either sex, in which a blank hole was left unfilled in a group of six specimens to act as control. The bone formation response of the three implanting materials in vivo has been studied using scanning electron microscope and histological analysis in contrast with positive controls. Push-out tests were used to assess the mechanical strength at the bone-biomaterial interface. It was observed that interfacial response was strongly dependent on combinations of different physical and chemical parameters. The surface of beta-TCP exhibited similar characteristics of bone and was distinct from those of intervening apatite layer of bioglass. Lower bone ingrowth and reduced strength was observed with HAp compared to beta-TCP/bioglass-based implants. Bone formation response of the Ca-P material varied according to the composition of the implanting material, which could be tailored through this novel synthesis.
authors.affiliation: Central Glass and Ceramic Research Institute, Kolkata, India.
authors.forename: Samir K
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Samit K
authors.initials: SK
authors.lastname: Nandi
authors.forename: Biswanath
authors.initials: B
authors.lastname: Kundu
authors.forename: Someswar
authors.initials: S
authors.lastname: Datta
authors.forename: Dipak K
authors.initials: DK
authors.lastname: De
authors.forename: Sujit K
authors.initials: SK
authors.lastname: Roy
authors.forename: Debabrata
authors.initials: D
authors.lastname: Basu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics; D017886:Durapatite / Q000737:chemistry*; D004867:Equipment Design; D005260:Female; D006041:Goats; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D013314:Stress, Mechanical; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite