[Influence of chronic HBV infection in the husband on the outcome of IVF-ET treatment].
OBJECTIVE
To investigate the outcome of in vitro fertilization and embryo transfer (IVF-ET) in couples with the husband positive for chronic infection of hepatitis B virus (HBV).


METHODS
This study involved 102 infertile couples receiving IVF-ET with the husbands(but not the wives) positive for hepatitis B surface antigen (HBsAg), and another 204 couples negative for HBsAg receiving the treatment served as the control group. The cumulative embryo score, fertilization rate, cleavage rate, rate of good quality embryos, implantation rate, clinical pregnancy rate, first trimester and late miscarriage rates, delivery rate, and neonatal malformation rate were recorded and compared between the two groups.


RESULTS
Between the HBsAg-positive and the control groups, the cumulative embryo score (52.8-/+18.7 vs 55.4-/+16.9), insemination rate (66.9% vs 66.1%), cleavage rate (97.6% vs 97.2%), rate of good quality embryos (34.0% vs 37.1%), implantation rate (40.9% vs 34.6%), clinical pregnancy rate (56.9% vs 50%), first trimester miscarriage rate (6.9% vs 5.9%) and late pregnancy miscarriage rate (8.6% vs 4.9%), delivery rate (40.2% vs 43.6%) and neonatal malformation rate (0 vs 0) were all similar (P>0.05;).


CONCLUSIONS
Chronic HBV infection in the husband might not affect the outcome of IVF-ET treatment.
Zhao
Er-yong
EY
Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. zhaoeryong@126.com
Chen
Shi-ling
SL
Sun
Ling
L
Yin
Min-na
MN
Xiong
Xia-si
XS
Song
Juan
J
Song
Ya-nan
YN
Zhou
Yuan-ping
YP
D016022:Case-Control Studies; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome
D006514:Hepatitis B Surface Antigens