title: Two new lignans from the stem bark of Magnolia obovata and their cytotoxic activity.
abstract: Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 microg/ml.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: UiJoung
authors.initials: U
authors.lastname: Youn
authors.forename: Quan Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: Ik Soo
authors.initials: IS
authors.lastname: Lee
authors.forename: HongJin
authors.initials: H
authors.lastname: Kim
authors.forename: Jae-Kuk
authors.initials: JK
authors.lastname: Yoo
authors.forename: JongPill
authors.initials: J
authors.lastname: Lee
authors.forename: Minkyun
authors.initials: M
authors.lastname: Na
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002934:Cinnamates; D003374:Coumarins; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007564:Japan; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C525791:4-methoxymagnaldehyde B; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D003374:Coumarins; D017705:Lignans; C525792:coumanolignan