Regulation of tissue factor procoagulant activity by post-translational modifications.
Post-translational modification of amino acid residues is a common way to regulate localization, stability and ultimately the function of the protein. Tissue factor (TF), the major initiator of blood coagulation cascade, receives several post-translational modifications, like glycosylation, phosphorylation, palmitoylation and nitrosylation. Recent studies have demonstrated that these processes play important roles in modulating biological functions of TF. The present review highlights the mechanisms of several common protein post-translational modifications of TF with the special reference on the recent knowledge about their roles in regulation of trafficking, stability as well as procoagulant and signaling functions of TF.
Egorina
Elena M
EM
Department of Biochemistry, Institute of Medical Biology, University of Tromsø, N-9037, Tromsø, Norway. egorina@fagmed.uit.no
Sovershaev
Mikhail A
MA
Osterud
Bjarne
B
D000595:Amino Acid Sequence; D000818:Animals; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000378:metabolism; D019308:Palmitic Acid / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D013925:Thromboplastin / Q000737:chemistry / Q000378:metabolism*
D019308:Palmitic Acid; D009569:Nitric Oxide; D013925:Thromboplastin