[Application of D6S1043 and D12S391 loci in forensic paternity testing].
OBJECTIVE
The aim was to investigate the polymorphisms of D6S1043 and D12S391 loci among Han population and evaluate their values in paternity testing. MERTHODS: By using fluorescence dye-labeled primers and capillary electrophoresis, the allele frequencies of the two STR loci among 192 unrelated individuals were investigated.


RESULTS
Twelve alleles were observed in both D6S1043 and D12S391 loci. The ranges of allele frequencies were from 0.0026 to 0.1719 and from 0.0026 to 0.2292, respectively. The discrimination power of D6S1043 and D12S391 were 0.9656 and 0.9510. The Average exclusion probability in paternity testing for duos were 0.573 and 0.510. The Average exclusion probability in paternity testing for trios were 0.731 and 0.679, respectively. The genotypes frequencies met Hardy-Weinberg equilibrium expectation.


CONCLUSIONS
The results show that D6S1043 and D12S391 have high values in forensic paternity testing.
Guo
Hong
H
Medical School of Soochow University, Suzhou 215123, China. fyguo-2005@163.com
Lin
Yuan
Y
Liu
Yan
Y
Que
Ting-zhi
TZ
Yan
Pin-hua
PH
Zhao
Zhen-min
ZM
Li
Cheng-tao
CT
Li
Li
L
D000483:Alleles; D002681:China / Q000208:ethnology; D016172:DNA Fingerprinting / Q000379:methods*; D019075:Electrophoresis, Capillary; D005554:Forensic Medicine / Q000379:methods; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D010334:Paternity; D011336:Probability; D020080:Tandem Repeat Sequences / Q000235:genetics*