Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.
Bioactivity-guided fractionation of Notopterygium forbesii has resulted in the isolation of one new coumarin glycoside and one new phenethyl vanillate, together with seventeen known compounds. The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their binding affinities to the opioid and dopamine receptors, and falcarindiol showed weak binding affinities to opioid receptors and moderate affinity for D1 receptor (K(i)=192+/-6 nM).
Ma
Zhongze
Z
Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Xu
Wei
W
Liu-Chen
Lee-Yuan
LY
Lee
David Y W
DY
D000818:Animals; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D053280:Diynes / Q000737:chemistry; D005233:Fatty Alcohols / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D011485:Protein Binding; D011954:Receptors, Dopamine / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013057:Spectrum Analysis; D014641:Vanillic Acid / Q000737:chemistry* / Q000302:isolation & purification
D003374:Coumarins; D053280:Diynes; D005233:Fatty Alcohols; D006027:Glycosides; D011954:Receptors, Dopamine; D011957:Receptors, Opioid; C034379:falcarindiol; C030123:coumarin; D014641:Vanillic Acid