Impact of MLC leaf position errors on simple and complex IMRT plans for head and neck cancer.
The dosimetric impact of random and systematic multi-leaf collimator (MLC) leaf position errors is relatively unknown for head and neck intensity-modulated radiotherapy (IMRT) patients. In this report we studied 17 head and neck IMRT patients, including 12 treated with simple plans (<50 segments) and 5 treated with complex plans (>100 segments). Random errors (-2 to +2 mm) and systematic errors (+/-0.5 mm and +/-1 mm) in MLC leaf positions were introduced into the clinical plans and the resultant dose distributions were analyzed based on defined endpoint doses. The dosimetric effect was insignificant for random MLC leaf position errors up to 2 mm for both simple and complex plans. However, for systematic MLC leaf position errors, we found significant dosimetric differences between the simple and complex IMRT plans. For 1 mm systematic error, the average changes in D(95%) were 4% in simple plans versus 8% in complex plans. The average changes in D(0.1 cc) of the spinal cord and brain stem were 4% in simple plans versus 12% in complex plans. The average changes in parotid glands were 9% in simple plans versus 13% for the complex plans. Overall, simple IMRT plans are less sensitive to leaf position errors than complex IMRT plans.
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Department of Radiation Oncology, University of California, San Francisco, CA, USA.
Ludlum
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Xia
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D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods* / Q000706:statistics & numerical data; D012189:Retrospective Studies