An efficient three-component one-pot approach to the synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepines by means of rhodium-catalyzed hydroaminomethylation.
We have developed a novel and efficient three-component one-pot, catalytic approach for the synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepines, using a rhodium catalyst that does not require phosphine. The isolated yields are excellent and the protocol tolerates anilines of diverse basicity.
Vieira
Tiago O
TO
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
Alper
Howard
H
D001552:Benzazepines / Q000138:chemical synthesis*; D002384:Catalysis; D008745:Methylation; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
D001552:Benzazepines; D010720:Phosphines; D012238:Rhodium; C044646:phosphine