[Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis].
OBJECTIVE
To investigate the expression of alpha-smooth muscle action (alpha-SMA) in the renal tubulointerstitium in patients with kidney collateral stasis.


METHODS
The expression of alpha-SMA in the renal biopsy specimens from 54 patients with kidney collateral stasis was examined by immunohistochemical method.


RESULTS
The degree of kidney collateral stasis was increased with the increasing of the degree of renal interstitial fibrosis (P<0.05), and there was significant positive correlation between kidney collateral stasis and alpha-SMA expression (P<0.05).


CONCLUSIONS
Kidney collateral stasis is one of the main reasons of renal fibrosis. With the increasing of kidney collateral stasis, MFBs in the renal interstitium proliferate obviously, becoming one of the most important causes of renal interstitial fibrosis.
Yang
Dong
D
Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi Province 710032, China.
DU
Yong-Ping
YP
Shen
Qing
Q
Chen
Wei
W
Yu
Yan
Y
Chen
Guang-Lei
GL
D000199:Actins / Q000032:analysis / Q000378:metabolism*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000378:metabolism*; D011379:Prognosis
C541116:ACTA2 protein, human; D000199:Actins