title: Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial.
abstract: OBJECTIVE
  To investigate the impact of zinc supplementation in children with cholera.
  
  
  METHODS
  Double blind, randomised, placebo controlled trial.
  
  
  METHODS
  Dhaka Hospital, Bangladesh.
  
  
  METHODS
  179 children aged 3-14 years with watery diarrhoea and stool dark field examination positive for Vibrio cholerae and confirmed by stool culture.
  
  
  METHODS
  Children were randomised to receive 30 mg elemental zinc per day (n=90) or placebo (n=89) until recovery. All children received erythromycin suspension orally in a dose of 12.5 mg/kg every six hours for three days.
  
  
  METHODS
  Duration of diarrhoea and stool output. Results 82 children in each group completed the study. More patients in the zinc group than in the control group recovered by two days (49% v 32%, P=0.032) and by three days (81% v 68%, P=0.03). Zinc supplemented patients had 12% shorter duration of diarrhoea than control patients (64.1 v 72.8 h, P=0.028) and 11% less stool output (1.6 v 1.8 kg/day, P=0.039).
  
  
  CONCLUSIONS
  Zinc supplementation significantly reduced the duration of diarrhoea and stool output in children with cholera. Children with cholera should be supplemented with zinc to reduce its duration and severity.
  
  
  BACKGROUND
  Clinical trials NCT00226616.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka -1212, Bangladesh. skroy@icddrb.org
authors.forename: S K
authors.initials: SK
authors.lastname: Roy
authors.forename: M Jahangir
authors.initials: MJ
authors.lastname: Hossain
authors.forename: Wajiha
authors.initials: W
authors.lastname: Khatun
authors.forename: Barnali
authors.initials: B
authors.lastname: Chakraborty
authors.forename: S
authors.initials: S
authors.lastname: Chowdhury
authors.forename: Afroza
authors.initials: A
authors.lastname: Begum
authors.forename: Syeda
authors.initials: S
authors.lastname: Mah-e-Muneer
authors.forename: Sohana
authors.initials: S
authors.lastname: Shafique
authors.forename: Mansura
authors.initials: M
authors.lastname: Khanam
authors.forename: R
authors.initials: R
authors.lastname: Chowdhury
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000188:drug therapy*; D003967:Diarrhea / Q000517:prevention & control; D019587:Dietary Supplements; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D015032:Zinc