Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts.
Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent.
Kim
Sangmin
S
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea. ksm3005@hotmail.com
Chung
Jin Ho
JH
D000328:Adult; D001599:Berberine / Q000494:pharmacology*; D015153:Blotting, Western; D002478:Cells, Cultured; D024042:Collagen Type I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004790:Enzyme Induction; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D061965:Matrix Metalloproteinase Inhibitors; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014466:Ultraviolet Rays
D024042:Collagen Type I; D061965:Matrix Metalloproteinase Inhibitors; D001599:Berberine; D020781:Matrix Metalloproteinase 1