title: High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
abstract: We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
authors.affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Kasprowicz
authors.forename: Julian
authors.initials: J
authors.lastname: Schulze Zur Wiesch
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuntzen
authors.forename: Brian E
authors.initials: BE
authors.lastname: Nolan
authors.forename: Steven
authors.initials: S
authors.lastname: Longworth
authors.forename: Andrew
authors.initials: A
authors.lastname: Berical
authors.forename: Jenna
authors.initials: J
authors.lastname: Blum
authors.forename: Cory
authors.initials: C
authors.lastname: McMahon
authors.forename: Laura L
authors.initials: LL
authors.lastname: Reyor
authors.forename: Nahel
authors.initials: N
authors.lastname: Elias
authors.forename: William W
authors.initials: WW
authors.lastname: Kwok
authors.forename: Barbara G
authors.initials: BG
authors.lastname: McGovern
authors.forename: Gordon
authors.initials: G
authors.lastname: Freeman
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Chung
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
authors.forename: Lia
authors.initials: L
authors.lastname: Lewis-Ximenez
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
authors.forename: Arthur Y
authors.initials: AY
authors.lastname: Kim
authors.forename: Georg M
authors.initials: GM
authors.lastname: Lauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D015415:Biomarkers; D018106:CD28 Antigens / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular; D008099:Liver / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D061026:Programmed Cell Death 1 Receptor
chemical_list: D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D018106:CD28 Antigens; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor