Rapid-sequence endoscopic management of posttransplant anastomotic biliary strictures.
BACKGROUND
Post-liver-transplant anastomotic biliary strictures generally have been managed through ERCP with gradual balloon dilation and placement of multiple stents over an extended period of time.


OBJECTIVE
Our purpose was to evaluate the long-term outcome of rapid sequence dilation and to shorten the duration of stenting as a therapy for anastomotic biliary strictures.


METHODS
Prospective case series.


METHODS
Academic tertiary referral center.


METHODS
ERCP with rapid-sequence balloon dilation of post-liver-transplant anastomotic biliary strictures followed by stenting with multiple stents over a short time period.


METHODS
Long-term anastomotic stricture resolution.


RESULTS
Thirty-eight patients were prospectively enrolled into a standardized ERCP treatment protocol. The mean number of ERCPs per patient was 3.4 (range 2-6), the mean number of maximum stents inserted was 2.5 (range 1-6), and the mean total stenting period was 107 days (range 20-198 days); the mean follow-up time from completion of the endoscopic therapy was 360 days (range 140-1347 days). Long-term stricture resolution was achieved in 33 of the 38 (87%) patients.


CONCLUSIONS
Lack of control group, relatively small patient population.


CONCLUSIONS
Accelerated dilation and shorter total length of stenting leads to long-term success in the majority of patients with post-liver-transplant anastomotic biliary strictures.
Morelli
Giuseppe
G
Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610-0214, USA.
Fazel
Ali
A
Judah
Joel
J
Pan
Jen Jung
JJ
Forsmark
Chris
C
Draganov
Peter
P
D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001660:Biliary Tract Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D003251:Constriction, Pathologic; D016145:Endoscopy, Digestive System / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019919:Prosthesis Implantation / Q000295:instrumentation; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome