Copper-catalyzed aerobic oxidative amidation of terminal alkynes: efficient synthesis of ynamides.
A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.
Hamada
Tetsuya
T
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
Ye
Xuan
X
Stahl
Shannon S
SS
D000332:Aerobiosis; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D010084:Oxidation-Reduction
D000480:Alkynes; D000577:Amides; D003300:Copper