title: Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review.
abstract: OBJECTIVE
  The treatment recommendations from the 2005 International Consensus Conference on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science (hosted by the American Heart Association) advocate a goal-directed treatment strategy for hemodynamic optimization after return of spontaneous circulation (ROSC) in post-cardiac arrest care. We performed a systematic review to (1) examine the available evidence for goal-directed hemodynamic support in the post-cardiac arrest syndrome, (2) determine the effect of such a treatment strategy on survival, and (3) define the specific hemodynamic goals, if any, that have been tested in clinical trials of post-cardiac arrest patients.
  
  
  METHODS
  We conducted a systematic review of the Cochrane Library, MEDLINE, CINAHL, conference proceedings, clinical practice guidelines, and other sources using a comprehensive strategy to identify randomized controlled trials and quasi-experimental studies of goal-directed hemodynamic optimization in patients with ROSC after cardiac arrest.
  
  
  RESULTS
  The comprehensive search yielded a total of 1184 potential publications and after a relevance screen, five studies were eligible for full article review. None of the studies were eligible for inclusion in the final analysis.
  
  
  CONCLUSIONS
  To date, no clinical trials have examined hemodynamic optimization in post-cardiac arrest patients. Although clinical acumen may support the concept that hemodynamic derangements after ROSC should be normalized, there is currently no evidence available to indicate the best strategy for goal-directed hemodynamic support. The current study indicates the need for future clinical investigations designed to determine both the efficacy of hemodynamic optimization in post-cardiac arrest patients and the best endpoints to target as part of a goal-directed strategy.
authors.affiliation: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, United States.
authors.forename: Alan E
authors.initials: AE
authors.lastname: Jones
authors.forename: Nathan I
authors.initials: NI
authors.lastname: Shapiro
authors.forename: J Hope
authors.initials: JH
authors.lastname: Kilgannon
authors.forename: Stephen
authors.initials: S
authors.lastname: Trzeciak
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects* / Q000379:methods*; D016009:Chi-Square Distribution; D006323:Heart Arrest / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006801:Humans; D007049:Iatrogenic Disease; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D013577:Syndrome