Obesity differentially affects serum levels of androstenedione and testosterone in polycystic ovary syndrome.
OBJECTIVE
To assess androstenedione (A) and T levels in obese and nonobese patients with polycystic ovary syndrome (PCOS) after GnRH and oral glucose tolerance tests (OGTT).


METHODS
Cross sectional study.


METHODS
Clinical research center.


METHODS
Thirty patients with PCOS, of whom 15 were obese and 15 were nonobese, and 7 women without PCOS were included in the study.


METHODS
The GnRH test and OGTT were performed in all subjects.


METHODS
Basal and stimulated levels of LH, FSH, insulin, A, and total T were measured. Areas under the curve (AUCs) and AUC change after stimulation for these hormones were calculated.


RESULTS
The basal T levels were significantly higher in obese than in nonobese patients with PCOS. In contrast, the basal levels of A were similar in obese and nonobese patients with PCOS. The T(AUC) after GnRH was significantly greater in obese than in nonobese patients with PCOS but was not significantly different after OGTT. The A(AUC) after GnRH and OGTT was significantly greater in nonobese than in obese patients with PCOS. However, there were no significant differences in T(AUC) and A(AUC) changes after GnRH and OGTT.


CONCLUSIONS
A different pattern in the levels of T and A with respect to obesity in PCOS was observed, suggesting a shift in ovarian enzymatic function.
Moran
Carlos
C
Health Research Council, Mexican Institute of Social Security, Mexico City, Mexico. cemoranv@hotmail.com
Renteria
Jose L
JL
Moran
Segundo
S
Herrera
Joaquin
J
Gonzalez
Sandra
S
Bermudez
Jose A
JA
D000328:Adult; D000735:Androstenedione / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005951:Glucose Tolerance Test; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications; D010050:Ovarian Function Tests; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood*; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone