[Ghrelin and its influence on cardiovascular system].
Ghrelin plays an important role in regulation of feeding behavior and energy homeostasis. It stimulates the release of growth hormone (GH) from pituitary and also activates its receptors expressed e.g. in the heart, aorta and coronary arteries. Ghrelin besides its orexigenic influences also improves left ventricular function in men and rats. It inhibits both apoptosis and expression of proinflammatory cytokines by cardiomyocytes and endothelial cells. Based on the contemporary .literature we present the influence of ghrelin on cardiovascular diseases and atherosclerosis.
Dubiński
Andrzej
A
Powiatowego Centrum Zdrowia w Kamiennej Górze Szpitala Powiatowego Spółka z o.o. NZOZ. dolvita@mp.pl
Zdrojewicz
Zygmunt
Z
D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D054439:Ghrelin / Q000502:physiology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D051381:Rats
D054439:Ghrelin; D013006:Growth Hormone