Association of beta 2-adrenergic receptor polymorphism with the phenotype of aspirin-intolerant acute urticaria.
The genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the beta 2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria (AICU), and 498 normal healthy controls (NC) based on a Korean population were enrolled. The genotype of ADRB2 at 46 A > G was analyzed using a direct sequencing method. The ADRB2 polymorphism at 46 A > G showed a significant difference between AIAU and NC; the frequency of the major genotype was significantly higher in the AIAU group (p= 0.017 in recessive model), while no differences were noted in allele and genotype frequencies between AICU and NC. In conclusion, the ADRB2 (46 A > G) gene polymorphism may contribute to the development of the phenotype of AIAU.
Kim
Hyoun-Ah
HA
Department of Allergy and Rheumatology, Ajou University School of Medicine, San-5 Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.
Ye
Young-Min
YM
Kim
Seung-Hyun
SH
Hur
Gyu-Young
GY
Park
Hae-Sim
HS
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D014581:Urticaria / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology
D018343:Receptors, Adrenergic, beta-2; D001241:Aspirin