CD47: a new target in cardiovascular therapy.
CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity. The recent discovery that thrombospondin-1 acts via CD47 to inhibit nitric oxide signaling throughout the vascular system has given new importance and perhaps a unifying mechanism of action to these enigmatic proteins. Here we trace the development of this exciting new paradigm for CD47 function in vascular physiology.
Isenberg
Jeff S
JS
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Roberts
David D
DD
Frazier
William A
WA
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D051928:CD47 Antigen / Q000737:chemistry / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D008958:Models, Molecular; D009569:Nitric Oxide / Q000502:physiology; D015398:Signal Transduction; D019700:Thrombospondin 1 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology
D051928:CD47 Antigen; D019700:Thrombospondin 1; D009569:Nitric Oxide