Low- and high-frequency electric cortical stimulation suppress the ferric chloride-induced seizures in rats.
The clinic treatment of epilepsy with epileptic foci overlapped with eloquent cortex is not satisfactory. In this study we investigated the direct effects of low- and high-frequency electric cortical stimulation (ECS) on ferric chloride-induced seizures in the experimental rats. Results showed that spontaneous seizures were observed in all rats during the EEG recording after the intracortical injection of ferric chloride solution into left sensorimotor cortex. One-hertz or 100-Hz ECS with 0.3 ms duration and 0.1 mA amplitude square pulses in 1h on the cortical lesioned area significantly decreased the number of seizures compared with that of the non-stimulation control group. The mean duration time of seizures in 1-Hz or 100-Hz groups was apparently shorter than that in the control group. In brief, this study showed that both low- and high-frequency ECS suppressed the seizures induced by ferric chloride in rats, indicating their potential treatment effects on epilepsy in clinic.
Yao
Qing-He
QH
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xin-shi Road, Shaanxi Province, Xi'an, China.
Zhang
Hua
H
Wang
Hai-Wei
HW
Jing
Xiao-Rong
XR
Guo
Heng
H
Gao
Guo-Dong
GD
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D002712:Chlorides; D003292:Convulsants; D004599:Electric Stimulation Therapy / Q000379:methods*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D005290:Ferric Compounds; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000503:physiopathology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000187:drug effects / Q000503:physiopathology; D016896:Treatment Outcome
D002712:Chlorides; D003292:Convulsants; D005290:Ferric Compounds; C024555:ferric chloride