title: Mineral metabolism in obese patients following vertical banded gastroplasty.
abstract: BACKGROUND
  Bone disease has been described in patients after surgical treatment for obesity, but few studies have dealt with the impact of vertical banded gastroplasty on mineral metabolism. We have examined bone mineral metabolism in morbidly obese patients before and after 3 months after vertical banded gastroplasty without vitamin D supplementation.
  
  
  METHODS
  Sixteen morbidly obese patients (14 women, 2 men) with a mean (+/-SD) age of 38 +/- 9 years and a body mass index (BMI) of 47.1 +/- 8.1 kg/m2 were studied. No vitamin D supplementation was given. Body weight, fat mass, calcium, 25OHD, iPTH, bone remodeling markers, and leptin levels were measured at baseline and after weight loss.
  
  
  RESULTS
  Mean weight loss was 28 +/- 11 kg; BMI and body fat mass decreased by 20 and 35%, respectively. Bone resorption markers and albumin-corrected serum calcium increased after operation, whereas iPTH fell. Serum 25OHD levels rose. Leptin levels decreased. Serum iPTH was positively correlated with weight, BMI, and fat mass before operation (p < 0.05), and its decline after weight reduction was negatively associated with the increase in bone resorption markers (p < 0.01). Leptin concentration was correlated with BMI and body fat mass (p < 0.05) both before and after surgery.
  
  
  CONCLUSIONS
  Weight reduction obtained in morbidly obese subjects 3 months after vertical banded gastroplasty increases bone turnover markers and decreases PTH secretion. Serum 25OHD levels rose. Therefore, no reasons for a metabolic bone disease related to hypovitaminosis D were readily apparent. However, an increase in bone turnover, which is generally regarded as a potential risk factor for osteoporosis, was observed. Further work is needed to clarify the importance of this turnover increase in the long run.
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain. miromj@humv.es
authors.forename: José M
authors.initials: JM
authors.lastname: Olmos
authors.forename: Luis A
authors.initials: LA
authors.lastname: Vázquez
authors.forename: José A
authors.initials: JA
authors.lastname: Amado
authors.forename: José L
authors.initials: JL
authors.lastname: Hernández
authors.forename: Jesús
authors.initials: J
authors.lastname: González Macías
mesh_terms: D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000209:etiology; D016723:Bone Remodeling; D005260:Female; D015391:Gastroplasty / Q000009:adverse effects; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D010024:Osteoporosis / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood; D012307:Risk Factors
chemical_list: D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone