[Protective effect of proteasome inhibitor MG-132 in rats with severe acute pancreatitis and lung injury].
OBJECTIVE
To observe the protective effect of the proteasome inhibitor MG-132 in rats with severe acute pancreatitis (SAP) and the associated lung injury.


METHODS
In rat models of the SAP established with injection of 5% sodium taurocholate into the biliary-pancreatic duct, the changes of the serum amylase and myeloperoxidase (MPO) activity in the pancreatic and lung tissues were evaluated. The pathological changes of the pancreatic and lung tissues were also observed.


RESULTS
MG-132 significantly decreased serum amylase, pancreatic weight/body weight ratio, and pancreatic and pulmonary myeloperoxidase activity (P<0.05). Histopathological examinations revealed milder edema, cellular damage, and inflammation in the pancreatic and lung tissues of rats pretreated with the peptide (P<0.05).


CONCLUSIONS
MG-132 ameliorates SAP and the associated lung injury in rats.
Li
Shun-le
SL
Department of General Surgery, Second Affiliated Hospital of College of Medicine, Xi'an Jiaotong University, Xi'an 710004, China. lishunle@ sina.com
Chen
Xi
X
Wu
Tao
T
Liu
Ji-dong
JD
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D007976:Leupeptins / Q000494:pharmacology*; D008168:Lung / Q000473:pathology; D055370:Lung Injury / Q000188:drug therapy*; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy*; D009195:Peroxidase / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
D015853:Cysteine Proteinase Inhibitors; D007976:Leupeptins; D009195:Peroxidase; D000681:Amylases; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde