Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys.
The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6-hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate-induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP-treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short-lasting, and mild change in the parkinsonian motor scale but no effect against levodopa-induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa-induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified.
Lanciego
Jose L
JL
Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain.
Rodríguez-Oroz
Maria C
MC
Blesa
Francisco J
FJ
Alvarez-Erviti
Lydia
L
Guridi
Jorge
J
Barroso-Chinea
Pedro
P
Smith
Yoland
Y
Obeso
Jose A
JA
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis; D007839:Functional Laterality / Q000187:drug effects; D020646:Intralaminar Thalamic Nuclei / Q000187:drug effects* / Q000473:pathology; D007608:Kainic Acid / Q000633:toxicity*; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008252:Macaca fascicularis; D008297:Male; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D013238:Stereotaxic Techniques
D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D007608:Kainic Acid