title: T/NK cell lymphoma presenting as a "blocked nose".
abstract: We present the case of a 63-year-old Caucasian male who complained of persistent rhinitis and sinusitis accompanied by a total left-sided nasal blockage. The diagnosis nasal T/NK cell lymphoma was established by histopathological investigation. This case was diagnosed as stage IE lymphoma as no other sites were involved. The patient was treated with CHOP (cyclophosfamide, doxorubicin, vincristin and prednisone) chemotherapy and involved-field radiotherapy. The nasal T/NK cell lymphoma is a rare malignancy, which is known to have an extremely aggressive and destructive course. The mainstay of treatment is locoregional radiotherapy combined with chemotherapy, depending on disease stage. A high index of clinical suspicion is imperative to ensure early diagnosis and ultimately improve disease outcome.
authors.affiliation: Department of Head and Neck Surgery, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, Amsterdam, The Netherlands. n.ketharanathan@gmail.com
authors.forename: Naomi
authors.initials: N
authors.lastname: Ketharanathan
authors.forename: Peter Jan
authors.initials: PJ
authors.lastname: van Kipshagen
authors.forename: Wies
authors.initials: W
authors.lastname: Vasmel
authors.forename: Ellis
authors.initials: E
authors.lastname: Barbé
authors.forename: Nico
authors.initials: N
authors.lastname: de Vries
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor