Impact of aneurysmal geometry on intraaneurysmal flow: a computerized flow simulation study.
BACKGROUND
This study was performed to assess the effect of aneurysm geometry on parameters that may have an impact on the natural history of intracranial aneurysms, such as intraaneurysmal flow pressure and shear stress.


METHODS
Flow was simulated in 21 randomly selected aneurysms using finite volume modeling. Ten aneurysms were classified as side-wall aneurysms, with either single-sided or circumferential involvement of the parent artery wall, and 11 as bifurcation aneurysms (symmetric or asymmetric), with an axis either perpendicular or parallel to the parent artery. The flow patterns were classified as either jet or vortex types (with regular or irregular vortex flow). Pressures and shear stresses were characterized as evenly or unevenly distributed over the aneurysm wall and neck.


RESULTS
All side-wall and four of the bifurcation aneurysms with a perpendicular axis had a vortex type flow pattern and seven bifurcation aneurysms with a parallel axis (four symmetric and two asymmetric) had a jet flow pattern. Jet type flow was associated with an uneven pressure distribution in seven out of seven aneurysms. Vortex type flow resulted in an even pressure distribution in five out of six aneurysms with an irregular flow pattern and six out of eight with a regular flow pattern. No firm relationship could be established between any geometrical type and shear stress distribution. Only 1 of 14 aneurysms with a perpendicular axis, but 4 of 7 aneurysms with a parallel axis, had ruptured.


CONCLUSIONS
Aneurysm geometry does have an impact on flow conditions. Aneurysms with a main axis parallel to the parent artery have a tendency to have a jet flow pattern and uneven distribution of unsteady pressure. These aneurysms may have a higher rate of rupture as than those with a main axis perpendicular to the parent artery.
Szikora
Istvan
I
Interventional Neuroradiology, National Institute of Neurosurgery, Budapest, Hungary. h13424szi@ella.hu
Paal
Gyorgy
G
Ugron
Adam
A
Nasztanovics
Ferenc
F
Marosfoi
Miklos
M
Berentei
Zsolt
Z
Kulcsar
Zsolt
Z
Lee
Wickly
W
Bojtar
Imre
I
Nyary
Istvan
I
D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D002533:Cerebral Angiography; D020342:Finite Element Analysis; D018056:Hemorheology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008959:Models, Neurological; D012039:Regional Blood Flow / Q000502:physiology*; D012189:Retrospective Studies; D014655:Vascular Resistance / Q000502:physiology