Role of the JNK signal transduction pathway in inflammatory bowel disease.
The c-Jun NH2-terminal Kinase (JNK) pathway represents one sub-group of the mitogen-activated protein (MAP) kinases which plays an important role in various inflammatory diseases states, including inflammatory bowel disease (IBD). Significant progress towards understanding the function of the JNK signaling pathway has been achieved during the past few years. Blockade of the JNK pathway with JNK inhibitors in animal models of IBD lead to resolution of intestinal inflammation. Current data suggest specific JNK inhibitors hold promise as novel therapies in IBD.
Roy
Praveen K
PK
Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, United States. roypk@health.missouri.edu
Rashid
Farzana
F
Bragg
Jack
J
Ibdah
Jamal A
JA
D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*
D048031:JNK Mitogen-Activated Protein Kinases