title: Fate of collagen-based implants used in pelvic floor surgery: a 2-year follow-up study in a rabbit model.
abstract: OBJECTIVE
  The purpose of this study was to compare the long-term host response to 2 different collagen matrices versus macroporous polypropylene mesh.
  
  
  METHODS
  Four full-thickness abdominal wall defects in 35 rabbits were reconstructed with either polypropylene (Prolene), porcine dermal (Pelvicol), or small intestine submucosal collagen matrix (SIS). Animals were sacrificed on day 30, 60, 90, 180, 365, 540, and 720 days to evaluate morphologic and biomechanical properties of explants.
  
  
  RESULTS
  Prolene provoked a fibrotic reaction within 30 days. SIS was entirely replaced by a thin fibrotic layer within 60 days. Pelvicol was encapsulated, remaining structurally unchanged up to 180 days. Thereafter, half underwent degradation by a foreign body reaction.
  
  
  CONCLUSIONS
  Prolene was integrated by an increasingly organised fibrotic scar while SIS was entirely remodelled within 60 days. Pelvicol implants underwent late onset (> or = 180 days) degradation. After 2 years of implantation there were no differences in tensiometric strength between the 3 different materials.
authors.affiliation: Centre for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Claerhout
authors.forename: Godelieve
authors.initials: G
authors.lastname: Verbist
authors.forename: Eric
authors.initials: E
authors.lastname: Verbeken
authors.forename: Maja
authors.initials: M
authors.lastname: Konstantinovic
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000704:Analysis of Variance; D000818:Animals; D003094:Collagen; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D007150:Immunohistochemistry; D020007:Implants, Experimental; D008297:Male; D017773:Pelvic Floor / Q000601:surgery; D011126:Polypropylenes; D011336:Probability; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation; D011817:Rabbits; D011897:Random Allocation; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013718:Tensile Strength; D013997:Time Factors
chemical_list: D011126:Polypropylenes; D003094:Collagen