title: Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection.
abstract: Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.
authors.affiliation: Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Erwan
authors.initials: E
authors.lastname: Piriou
authors.forename: Karel
authors.initials: K
authors.lastname: van Dort
authors.forename: Sigrid
authors.initials: S
authors.lastname: Otto
authors.forename: Marinus H J
authors.initials: MH
authors.lastname: van Oers
authors.forename: Debbie
authors.initials: D
authors.lastname: van Baarle
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D004279:DNA, Viral / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000821:virology*; D006678:HIV / Q000254:growth & development* / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D006679:HIV Seropositivity / Q000276:immunology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D019562:Viral Load
chemical_list: D004279:DNA, Viral