title: Secretory meningioma of the middle ear: a light microscopic, immunohistochemical and ultrastructural study of one case.
abstract: A 66-year-old woman was referred with left hearing loss. A probable diagnosis of left secretory otitis media with effusion was formulated. A left myringotomy was performed to remove hyperplastic hard tissue from the tympanic cavity. A high resolution CT scan of the temporal bone disclosed a soft-tissue mass completely involving the mastoid and tympanic cavity, surrounding the ossicular chain which appeared spared with no signs of infiltration. The histopathologic, immunohistochemical and ultrastructural response was secretory meningioma, a rare variant of conventional meningothelial meningioma in atypical sites.
authors.affiliation: Dipartimento Clinico di Scienze Radiologiche e Istocitopatologiche, Sezione di Anatomia e Istologia Patologica, Università di Bologna, Italy. giovanna.cenacchi@unibo.it
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cenacchi
authors.forename: Gian Gaetano
authors.initials: GG
authors.lastname: Ferri
authors.forename: Nunzio
authors.initials: N
authors.lastname: Salfi
authors.forename: Lucia
authors.initials: L
authors.lastname: Tarantino
authors.forename: Giovanni C
authors.initials: GC
authors.lastname: Modugno
authors.forename: Alberto Rinaldi
authors.initials: AR
authors.lastname: Ceroni
authors.forename: Giuseppe N
authors.initials: GN
authors.lastname: Martinelli
mesh_terms: D000368:Aged; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D003937:Diagnosis, Differential; D004432:Ear, Middle / Q000648:ultrastructure*; D005260:Female; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000150:complications / Q000378:metabolism / Q000648:ultrastructure*; D008579:Meningioma / Q000150:complications / Q000378:metabolism / Q000648:ultrastructure*; D018396:Mucin-1 / Q000378:metabolism; D010033:Otitis Media / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D018396:Mucin-1