title: Temporal regulation of the first mitosis in Xenopus and mouse embryos.
abstract: Cell cycle regulation in Eukaryotes is based on common molecular actors and mechanisms. However, the canonical cell cycle is modified in certain cells. Such modifications play a key role in oocyte maturation and embryonic development. They can be achieved either by introduction of new components, pathways, substrates, changed interactions between them, or by elimination of some factors inherited by the cells from previous developmental stages. Here we discuss a particular temporal regulation of the first embryonic M-phase of Xenopus and mouse embryos. These two examples help to understand better the general regulation of M-phase of the cell cycle.
authors.affiliation: CNRS/University of Rennes 1, Institute of Genetics & Development, UMR 6061, Mitosis & Meiosis Group, Faculty of Medicine, 2 Ave. Prof. Léon Bernard, CS 34317, 35043 Rennes Cedex, France. jacek.kubiak@univ-rennes1.fr
authors.forename: Jacek Z
authors.initials: JZ
authors.lastname: Kubiak
authors.forename: Franck
authors.initials: F
authors.lastname: Chesnel
authors.forename: Laurent
authors.initials: L
authors.lastname: Richard-Parpaillon
authors.forename: Franck
authors.initials: F
authors.lastname: Bazile
authors.forename: Aude
authors.initials: A
authors.lastname: Pascal
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Polanski
authors.forename: Marta
authors.initials: M
authors.lastname: Sikora-Polaczek
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Maciejewska
authors.forename: Maria A
authors.initials: MA
authors.lastname: Ciemerych
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D019926:Cyclin B / Q000502:physiology; D004622:Embryo, Mammalian / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D051379:Mice; D008938:Mitosis / Q000502:physiology*; D014981:Xenopus
chemical_list: D019926:Cyclin B; D048049:Extracellular Signal-Regulated MAP Kinases