title: Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.
abstract: The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.
authors.affiliation: Department of Chemistry, University of Louisville, KY 40292, USA.
authors.forename: José C
authors.initials: JC
authors.lastname: Aponte
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Rosario
authors.initials: R
authors.lastname: Rojas
authors.forename: Luz
authors.initials: L
authors.lastname: Caviedes
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
authors.forename: Gerardo
authors.initials: G
authors.lastname: Lamas
authors.forename: César
authors.initials: C
authors.lastname: Sarasara
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D053978:Pentacyclic Triterpenes; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry*; D031451:Strychnos / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000094062:Betulinic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid