title: [A rare primary tumor of the mediastinum: pleomorphic liposarcoma].
abstract: Liposarcoma of the mediastinum is a rare tumor with various histologic features. We report a case of mediatinal pleomorphic liposarcoma in a 37-year-old man who complained of chest pain. Computed tomography showed an anterior expansive process within the mediastinum. Histological diagnosis was established by a trans-thoracic computed tomography guided core-needle biopsy. Despite a first cure of chemotherapy with gemcitabin/cisplatin, disease progression led to death 3 months after diagnosis. Mediastinal pleomorphic liposarcoma is an exceptional invading tumor affecting the middle-aged adult. This tumor, usually giant, becomes symptomatic by compression of mediastinal structures. Surgery is the best treatment when possible. The role of radiotherapy and chemotherapy are discussed. Prognosis depends both on the quality of resection and the grade malignancy.
authors.affiliation: Service de Pneumo-Allergologie, CHU Hedi-Chaker, Sfax 3029, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Msaad
authors.forename: I
authors.initials: I
authors.lastname: Yangui
authors.forename: L
authors.initials: L
authors.lastname: Ayedi
authors.forename: W
authors.initials: W
authors.lastname: Ketata
authors.forename: T
authors.initials: T
authors.lastname: Sellami
authors.forename: A
authors.initials: A
authors.lastname: Ayoub
authors.forename: R
authors.initials: R
authors.lastname: Jlidi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002637:Chest Pain / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D017809:Fatal Outcome; D006801:Humans; D008080:Liposarcoma / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine