Insulin-releasing activity of a series of phenylalanine derivatives.
A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds (S)-3 and (R)-3 exhibited more potent insulin-releasing activity than that of nateglinide, compound (S)-3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo.
Tang
Lei
L
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yu
Juanhong
J
Wu
Haoshu
H
Fan
Houxing
H
Yang
Yushe
Y
Ji
Ruyun
R
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D051379:Mice; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D007328:Insulin; D010649:Phenylalanine