Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.
Changes in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy.
Rogers
Sophie Louise
SL
Centre for Eye Research, University of Melbourne, 32 Gisborne St., Victoria 3002, Australia.
Tikellis
Gabriella
G
Cheung
Ning
N
Tapp
Robyn
R
Shaw
Jonathan
J
Zimmet
Paul Z
PZ
Mitchell
Paul
P
Wang
Jie Jin
JJ
Wong
Tien Yin
TY
D001160:Arterioles / Q000033:anatomy & histology*; D001315:Australia; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003930:Diabetic Retinopathy / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012161:Retinal Artery / Q000503:physiopathology*
D001786:Blood Glucose