Incidence and risk factors for non-nucleoside reverse transcriptase inhibitors (NNRTI)-related rash in Thai children with HIV infection.
The present study evaluated the incidence and risk factors that correlated with the development of non-nucleoside reverse transcriptase inhibitor (NNRTI) related rash in 69 Thai children followed prospectively. The overall incidence of NNRTI-related rash was 16% (22% for NVP and 4% for EFV rash). The only significant predictive factor that correlated with the development of NNRTI-related rash in a multivariate logistic regression model was a CD4% decrease at week 12.
Vemula
Sunitha
S
Washington University, St. Louis, USA.
Kerr
Stephen
S
Pancharoen
Chitsanu
C
Siripong
Arida
A
Kosalaraksa
Pope
P
Engchanil
Chulapan
C
Chuamchaitrakool
Arpa
A
Intasan
Jintana
J
Lumbiganond
Pagakrong
P
Phanuphak
Praphan
P
Ananworanich
Jintanat
J
D019380:Anti-HIV Agents / Q000009:adverse effects*; D044966:Anti-Retroviral Agents / Q000009:adverse effects; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D005076:Exanthema / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000187:drug effects; D006801:Humans; D008297:Male; D011446:Prospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology
D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D018894:Reverse Transcriptase Inhibitors; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase