title: Bone mineral metabolism in children with biliary atresia after living related liver transplantation. Evaluation of selected parameters.
abstract: BACKGROUND
  Aim of the study was to analyze the effect of living related liver transplantation on selected parameters of bone formation and resorption in children with liver cirrhosis caused by biliary atresia.
  
  
  METHODS
  20 children (13F/7M) with biliary atresia aged from 6 month to 2.4 years were enrolled into the study 4-9 days before liver transplantation. Osteocalcin, procollagen 1 aminoterminal propeptide, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and metabolites of vitamin D: 25(OH)D3, 1,25(OH)2D3 were measured before, 3, 6 and 12 months after liver transplantation.
  
  
  RESULTS
  Three months after living related liver transplantation statistically significant increase of osteocalcin, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and 1,25(OH)2D3 levels were found. We didn't observe further increase of these parameters during the next 9 months after liver transplantation. There was no difference in 25(OH)D3 levels in patients before and after liver transplantation.
  
  
  CONCLUSIONS
  In children after successful living related liver transplantation we observed improvement of selected parameters of bone formation and resorption which indicate stimulation of growing processes and mechanisms of bone geometry modelling.
authors.affiliation: Department of Gastroenterology, Hepatology and Immunology, Children's Memorial Health Institute, Warsaw, Poland. m.teisseyre@chello.pl
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Teisseyre
authors.forename: Joanna
authors.initials: J
authors.lastname: Pawłowska
authors.forename: Edyta
authors.initials: E
authors.lastname: Kryśkiewicz
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Karczmarewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Czubkowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Dadalski
authors.forename: Irena
authors.initials: I
authors.lastname: Jankowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Teisseyre
authors.forename: Hor
authors.initials: H
authors.lastname: Ismail
authors.forename: Roman
authors.initials: R
authors.lastname: Lorenc
mesh_terms: D001656:Biliary Atresia / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D001862:Bone Resorption / Q000503:physiopathology*; D001842:Bone and Bones / Q000378:metabolism; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008903:Minerals / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D008903:Minerals