title: Detoxication treatment for carbamazepine and lithium overdose.
abstract: This article reports detoxication treatments of a case of combined overdose of carbamazepine and lithium in a 38-year-old female with bipolar disorder. She was brought to the emergency unit after the family found her unresponsive and lying near empty packages for carbamazepine (corresponded to 7.7 g) and lithium carbonate (corresponded to 6.6 g) tablets. On admission, her blood pressure, heart rate and respiratory rate were 80/55 mmHg, 90 per minute and 13 per minute, respectively. Her GCS was 3 (E1, M1, V1). She received gastric lavage after intratracheal intubation, followed by administration of activated charcoal via gastric tube, and a large volume (800 ml/h) of lactate Ringer's solution by intravenous infusion. The serum levels of carbamazepine and lithium approximately 5 h after ingestion were 56.0 mug/ml and 3.56 mEq/l, respectively. The carbamazepine overdose was mainly treated by a 3 h charcoal hemoperfusion (CHP). The CHP treatment decreased serum carbamazepine levels by approximately 30-40% as compared with the levels simulated by Bayesian analysis using 1-point or 2-points serum level(s) (without detoxication treatment). For lithium overdose continuous infusion of Ringer's solution was effective, which increased serum sodium gradually and facilitated the elimination of lithium. In conclusion, the treatments with CHP and continuous infusion of Ringer's solution were considered to be effective for detoxification of carbamazepine and lithium overdose, respectively, when compared with those drug levels without detoxication treatment that simulated by Bayesian analysis method.
authors.affiliation: Department of Pharmaceutical Services, Hiroshima University Hospital, Minami-ku, Hiroshima, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Unei
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Teruo
authors.initials: T
authors.lastname: Murakami
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanigawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Kihira
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D001714:Bipolar Disorder / Q000188:drug therapy; D002220:Carbamazepine / Q000506:poisoning*; D002606:Charcoal; D062787:Drug Overdose; D005260:Female; D005751:Gastric Lavage; D006464:Hemoperfusion; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D016651:Lithium Carbonate / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy*; D000077331:Ringer's Solution
chemical_list: D007552:Isotonic Solutions; D002606:Charcoal; D016651:Lithium Carbonate; D002220:Carbamazepine; D000077331:Ringer's Solution