title: European surveillance study on antimicrobial susceptibility of Gram-positive anaerobic cocci.
abstract: Gram-positive anaerobic cocci (GPAC) are a heterogeneous group of microorganisms frequently isolated from local and systemic infections. In this study, the antimicrobial susceptibilities of clinical strains isolated in 10 European countries were investigated. After identification of 299 GPAC to species level, the minimum inhibitory concentrations of penicillin, imipenem, clindamycin, metronidazole, vancomycin and linezolid were determined by the agar dilution method according to the Clinical and Laboratory Standards Institute. The majority of isolates were identified as Finegoldia magna and Parvimonas micra (formerly Peptostreptococcus micros), isolated from skin and soft tissue infections. All isolates were susceptible to imipenem, metronidazole, vancomycin and linezolid. Twenty-one isolates (7%) were resistant to penicillin (n=13) and/or to clindamycin (n=12). Four isolates were resistant to both agents. The majority of resistant isolates were identified as F. magna and originated from blood, abscesses and soft tissue infections.
authors.affiliation: Division of Clinical Microbiology, F68, Karolinska University Hospital, Huddinge SE-141 86, Stockholm, Sweden. brazier@cardiff.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Brazier
authors.forename: D
authors.initials: D
authors.lastname: Chmelar
authors.forename: L
authors.initials: L
authors.lastname: Dubreuil
authors.forename: G
authors.initials: G
authors.lastname: Feierl
authors.forename: M
authors.initials: M
authors.lastname: Hedberg
authors.forename: S
authors.initials: S
authors.lastname: Kalenic
authors.forename: E
authors.initials: E
authors.lastname: Könönen
authors.forename: B
authors.initials: B
authors.lastname: Lundgren
authors.forename: H
authors.initials: H
authors.lastname: Malamou-Ladas
authors.forename: E
authors.initials: E
authors.lastname: Nagy
authors.forename: A
authors.initials: A
authors.lastname: Sullivan
authors.forename: C E
authors.initials: CE
authors.lastname: Nord
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005060:Europe / Q000453:epidemiology; D016964:Gram-Negative Anaerobic Cocci / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D001618:beta-Lactamases / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases