QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone.
Trazodone possesses minimal anticholinergic properties and, therefore, is generally regarded as having less cardiotoxic potential than other antidepressants. This report describes a young woman who developed significant QT prolongation and delayed atrioventricular nodal conduction after acute trazodone overdose. The case adds to the existing literature because it has a number of strengths, namely that confounding drugs and alcohol were lacking, trazodone exposure was confirmed by drug assay, and early presentation to hospital gave a valuable opportunity to study the time-course of the cardiac effects. This case reminds us to consider the possibility of cardiotoxic effects after trazodone overdose, even in young patients with no established cardiovascular disease.
Service
Jennifer A
JA
Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom.
Waring
W Stephen
WS
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D013406:Suicide, Attempted; D014196:Trazodone / Q000506:poisoning*
D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone