title: Neurologic signs of ciguatera disease: evidence of their persistence.
abstract: Ciguatoxins exert their effect on the voltage-sensitive sodium channels of the cellular membranes of all excitable tissues. This effect confers to ciguatera disease (CD) its neurologic hallmarks. A prospective study among French Polynesian adults over a two-month period was conducted to characterize and determine the persistence of neurologic symptoms of CD. We compared 47 patients with CD with 125 controls. In the acute phase of the disease, patients had mainly sensory disturbances as detected by an hypoesthesia on the palm of the hand and poorer sway performance compared with controls. Follow-up two months showed improvement of sway performance that eventually reaching control levels. However, for light-touch threshold, even if we observed a decrease threshold towards normal values, more than 50% of patients did not reach normal values 60 days after disease onset. Our results support the existence of neurologic impairments of CD and suggest their persistence for at least two months after onset.
authors.affiliation: Public Health Research Unit, Laval University Medical Research Center, Sainte Foy, Quebec, Canada.
authors.forename: M-L
authors.initials: ML
authors.lastname: Chateau-Degat
authors.forename: A
authors.initials: A
authors.lastname: Beuter
authors.forename: G
authors.initials: G
authors.lastname: Vauterin
authors.forename: N L
authors.initials: NL
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Chinain
authors.forename: T
authors.initials: T
authors.lastname: Darius
authors.forename: A-M
authors.initials: AM
authors.lastname: Legrand
authors.forename: R
authors.initials: R
authors.lastname: Chansin
authors.forename: E
authors.initials: E
authors.lastname: Dewailly
mesh_terms: D000328:Adult; D036841:Ciguatera Poisoning / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced / Q000209:etiology*; D011114:Polynesia; D004856:Postural Balance; D011446:Prospective Studies; D012678:Sensation Disorders / Q000209:etiology*; D013997:Time Factors