Very low birth weight infants as a model to study genetic influences on neonatal weight gain.
In a cohort of 829 preterm infants (birth weight below 1500 g) we identified 13 monozygotic, 10 same-sex dizygotic, and 12 same-sex matched singleton pairs. The difference in daily weight gain within pairs was significantly lower in monozygotic twins compared with dizygotic twins or matched singleton pairs. Our data support a strong genetic influence on postnatal growth in preterm infants. Therefore, weight gain of preterm infants may be an interesting model to study polymorphic variants of genes regulating neonatal resorption, metabolism, or energy expenditure, and their influence on weight gain in preterm infants.
Spiegler
Juliane
J
*Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. spiegler@paedia.ukl.mu-luebeck.de
Kattner
Evelyn
E
Vochem
Matthias
M
Küster
Helmuth
H
Möller
Jens
J
Müller
Dirk
D
Kribs
Angela
A
Segerer
Hugo
H
Wieg
Christian
C
Nikischin
Werner
W
von der Wense
Axel
A
Gebauer
Corinna
C
Herting
Egbert
E
Göpel
Wolfgang
W
D005858:Germany; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008954:Models, Biological; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D015430:Weight Gain / Q000235:genetics*