title: Evaluation of the antigenic relationships among canine parvovirus type 2 variants.
abstract: The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, -2b, and -2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, -2b, and -2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2, CPV-2a, and CPV-2b. However, animals immunized with CPV-2c exhibited higher SN titers to CPV-2b than to the homologous virus CPV-2c. The observed antigenic differences might drive selection of CPV strains by generating differential immune pressure in the canine population, which raises concerns about vaccine efficacy.
authors.affiliation: Department of Animal Health and Well-Being, University of Bari, Valenzano, Bari, Italy. a.cavalli@veterinaria.uniba.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cavalli
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Costantina
authors.initials: C
authors.lastname: Desario
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Anna Lucia
authors.initials: AL
authors.lastname: Bellacicco
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Palo
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology*; D004283:Dog Diseases / Q000276:immunology* / Q000821:virology; D004285:Dogs; D006385:Hemagglutination Inhibition Tests; D007114:Immunization; D009500:Neutralization Tests; D010322:Parvoviridae Infections / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D011817:Rabbits
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral