Case reports: new onset flushing due to unauthorized substitution of niacin for nicotinamide.
Nicotinamide is the amide form of niacin and has anti-inflammatory properties that have led to its use in the treatment of several inflammatory dermatologic conditions, such as rosacea. Niacin has established its role in the prevention of coronary artery disease. Cutaneous flushing is a well-known and often dose-limiting side effect of niacin therapy, which does not occur with nicotinamide. We report a patient with rosacea who developed new onset flushing due to unauthorized substitution of niacin for nicotinamide. The anti-inflammatory mechanisms of nicotinamide and flushing mechanisms of niacin are discussed.
Kademian
Monique
M
Division of Dermatology, Ohio State University, Columbus, USA.
Bechtel
Mark
M
Zirwas
Matt
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D011307:Drug Prescriptions; D005260:Female; D005483:Flushing / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009525:Niacin / Q000009:adverse effects* / Q000627:therapeutic use; D009536:Niacinamide / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D009536:Niacinamide; D009525:Niacin