[The antisynthetase syndrome: a cause of rapidly progressive interstitial lung disease].
The anti-synthetase syndrome is associated with inflammatory myopathy, interstitial lung disease, polyarthritis, Raynaud's phenomenon and typical skin lesions known as "mechanic's hands". Anti-Jo1 antibodies are frequently present. Interstitial lung disease is the most important feature, as it determines survival and the therapeutic attitude. We report here two cases of anti-synthetase syndrome with acute respiratory failure. Immunosuppressive treatment combining corticosteroids and cyclosporine lead to clinical improvement, regression of radiological lesions and improvement in pulmonary functions.
Jordan Greco
Anne-Sophie
AS
Département de médecine interne, CHCVs/Hôpital de Sierre. asjordan@freesurf.ch
Métrailler
Jean-Claude
JC
Dayer
Eric
E
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D001168:Arthritis / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D009220:Myositis / Q000276:immunology; D012131:Respiratory Insufficiency / Q000188:drug therapy / Q000276:immunology; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents