A dead end for microRNAs.
Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide evidence that Dnd1 mediates these effects by counteracting microRNA-mediated silencing of mRNAs.
Ketting
René F
RF
Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands. ketting@niob.knaw.nl
D020413:3' Untranslated Regions; D000818:Animals; D001665:Binding Sites; D002470:Cell Survival / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D018031:Connexin 43 / Q000235:genetics / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009154:Mutation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D038621:Regulatory Sequences, Ribonucleic Acid; D014158:Transcription, Genetic; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
D020413:3' Untranslated Regions; D018031:Connexin 43; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D038621:Regulatory Sequences, Ribonucleic Acid; D029961:Zebrafish Proteins; C440015:nanos3 protein, zebrafish; D050760:Cyclin-Dependent Kinase Inhibitor p27; D017346:Protein Serine-Threonine Kinases