Synthesis and biological evaluation of LNA phosphoramidates.
The synthesis of LNA phosphoramidates is presented. The LNA phosphoramidates were evaluated for their ability to inhibit cell proliferation of the human prostate cancer cell line 15PC3. A number of the LNA phosphoramidates showed cell proliferation inhibition determined by the MTS assay.
Jensen
Jacob
J
Santaris Pharma A/S, Hørsholm, Denmark.
Sjøgren
Gitte
G
Hansen
Jens Bo
JB
Rosenbohm
Christoph
C
Koch
Troels
T
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012266:Ribose / Q000031:analogs & derivatives* / Q000737:chemistry
C434798:2'-O-4'-C-methylene-ribofuranosyl nucleotide; D000577:Amides; D009711:Nucleotides; D010756:Phosphoric Acids; D012266:Ribose; C011067:phosphoramidic acid