Colonic vascular anomalies and colon cancer in neurofibromatosis: report of a case.
We report a case of neurofibromatosis with synchronous adenocarcinomas in the sigmoid and transverse colon. There was widespread intimal proliferation in arteries in the region of the tumors and also in the cecum. Such vascular lesions are associated with von Recklinghausen's disease. The cecal lesion produced mural thickening visible on computed tomography. This case supports a possible genetic link between neurofibromatosis and adenocarcinoma of the colon.
Wood
James J
JJ
Department of General Surgery, Southmead Hospital, Bristol, BS2 5NB, United Kingdom. jimwood@doctors.net.uk
Longman
Robert J
RJ
Rooney
Nicholas
N
Loveday
Eric J
EJ
Roe
Alan M
AM
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D003106:Colon / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed