Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats.
In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kgb.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p<0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p<0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kgb.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kgb.w.
Kumar
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Division of Industrial Toxicology and Pollution Control, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamilnadu 627412, India. pgsvedhakumar@yahoo.com
Murugesan
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AG
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D019660:Malvaceae; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D000960:Hypolipidemic Agents; D008079:Lipoproteins, VLDL; D010936:Plant Extracts; D013311:Streptozocin