In vitro enhancement by CpG ODN of phagocytic activity of rainbow trout head kidney phagocytes against fish pathogen Vibrio ordalii, but not against polystyrene particles.
Rainbow trout (Oncorhynchus mykiss) head kidney phagocytes precultured with a synthetic cytidine-phosphate-guanosine (CpG) oligodeoxynucleotide (ODN) displayed significantly higher phagocytic activity against Vibrio ordalii than phagocytes precultured with non-CpG ODN. However, head kidney phagocytes precultured with CpG ODN did not show enhanced phagocytic activity against polystyrene particles.
Nakatani
Masahiro
M
Laboratory of Veterinary Immunology, Course of Veterinary Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Sakai, Osaka, Japan.
Iwasaki
Tadashi
T
Watarai
Shinobu
S
Kodama
Hiroshi
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005393:Fish Diseases / Q000382:microbiology; D007668:Kidney / Q000166:cytology; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D017686:Oncorhynchus mykiss; D010586:Phagocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D011137:Polystyrenes; D014733:Vibrio
D000900:Anti-Bacterial Agents; C408982:CPG-oligonucleotide; D009838:Oligodeoxyribonucleotides; D011137:Polystyrenes