Novel therapeutic targets at the platelet vascular interface.
Platelet activation in vivo can be part of the hemostatic response to injury or a pathological response to disease. In either setting, platelets adhere to the vessel wall and to each other, forming a closely packed mass interspersed with fibrin. Recent studies have identified new molecules on the platelet surface and within platelets that support and regulate thrombus growth and stability, ensuring that platelet accumulation after injury is sufficient to stop bleeding, but not so exuberant that vascular occlusion occurs. An understanding of how this balance is achieved helps to illuminate the events of platelet activation and, at the same time, provides potential targets for new classes of antiplatelet agents.
Brass
Lawrence F
LF
University of Pennsylvania, Department of Medicine, Division of Hematology-Oncology, Philadelphia, PA 19104, USA. Brass@mail.med.upenn.edu
Zhu
Li
L
Stalker
Timothy J
TJ
D000818:Animals; D004502:Education, Medical, Continuing; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000187:drug effects / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D015398:Signal Transduction; D013923:Thromboembolism / Q000517:prevention & control*; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects* / Q000378:metabolism
D016023:Integrins; D010975:Platelet Aggregation Inhibitors; D019010:Vascular Cell Adhesion Molecule-1