Activated protein C resistance and factor V Leiden in Mexico.
A common cause of hereditary thrombophilia is activated protein C resistance (APCR), and most cases result from factor V Leiden mutation. An APCR phenotype without association with factor V Leiden has been described. This transversal, observational, nonrandomized study evaluated these 2 phenomena in healthy indigenous and mestizo Mexican subjects (n = 4345), including 600 Mexican natives. No indigenous subjects had APCR, but 82 mestizo subjects did. After retesting, 50 subjects had a negative test. The remaining 32 subjects had factor V Leiden, giving a 0.85% prevalence of factor V Leiden in the mestizo Mexican population. Only 31% of APCR carriers had factor V Leiden. These results show a very low prevalence of APCR and factor V Leiden in Mexico. Except for factor V Leiden, there are no other mutations in the factor V gene responsible for the APCR phenotype. Acquired APCR is nearly twice as prevalent as the inherited variant.
Majluf-Cruz
Abraham
A
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico. amajlufc@prodigy.netmx
Moreno-Hernández
Manuel
M
Ruiz-de-Chávez-Ochoa
Adriana
A
Monroy-García
Rosario
R
Majluf-Cruz
Karim
K
Guardado-Mendoza
Rodolfo
R
Molina-Avila
Irma
I
Isordia-Salas
Irma
I
Corona-de la Peña
Norma
N
Vargas-Vorackova
Florencia
F
Vela-Ojeda
Jorge
J
García-Chávez
Jaime
J
D020016:Activated Protein C Resistance / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence
C095381:factor V Leiden; D005165:Factor V