title: Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusion.
abstract: Recent studies emphasized the non-lipid-lowering effects of hydroxymethylglutaryl coenzyme A reductase inhibitors on endothelial function, inflammation, and platelet activation in patients with stable atherosclerosis. This study sought to evaluate the impact of statin pretreatment in patients with acute myocardial infarction (AMI) on level of systemic inflammation and myocardial perfusion. A total of 253 consecutive patients undergoing primary angioplasty on a native vessel within 12 hours of AMI were divided into a group with statin pretreatment (n = 86) and control patients (n = 167). Angiographic myocardial blush grade (MBG) after revascularization of the infarct-related artery was determined to evaluate myocardial perfusion. Statin pretreatment was associated with a lower frequency of increased C-reactive protein (>or=5 mg/L) on admission compared with the control group (48% vs 64%; p = 0.019). The frequency of normal perfusion (MBG 3) was higher in the statin-pretreatment group than the control group (45% vs 26%, respectively; p <0.001). Statin pretreatment was an independent predictor of normal myocardial perfusion (MBG 3; odds ratio 2.53, 95% confidence interval 1.15 to 9.53, p = 0.022) in addition to age <or=70 years and C-reactive protein <5 mg/L. In conclusion, statin pretreatment in patients with AMI was associated with decreased systemic inflammation and better perfusion after primary angioplasty of the infarct-related artery.
authors.affiliation: Medical Clinic I, University Hospital RWTH, Aachen, Germany. rhoffmann@ukaachen.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Philipp
authors.initials: P
authors.lastname: Haager
authors.forename: Hasna
authors.initials: H
authors.lastname: Suliman
authors.forename: Philipp
authors.initials: P
authors.lastname: Christott
authors.forename: Peter
authors.initials: P
authors.lastname: Radke
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Blindt
authors.forename: Malte
authors.initials: M
authors.lastname: Kelm
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein; D017023:Coronary Angiography; D003326:Coronary Circulation; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D011300:Preoperative Care; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein