title: An efficient and scalable synthesis of 2,6-diaminopurine riboside.
abstract: An efficient process to synthesize 2,6-diaminopurine riboside in high yield and quality is described. This inexpensive approach was scaled up to multi-hundred kilogram quantities for use in oligonucleotide therapeutics.
authors.affiliation: Isis Pharmaceuticals, Inc., Carlsbad, California, USA.
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Ross
authors.forename: Robert H
authors.initials: RH
authors.lastname: Springer
authors.forename: Vasulinga T
authors.initials: VT
authors.lastname: Ravikumar
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D009843:Oligoribonucleotides; C033854:2-aminoadenosine; D000241:Adenosine