[The usefulness of plasma cystatin C determination as a marker of glomerular filtration rate].
Cystatin C is a low molecular weight protein; a cysteine proteinase inhibitor. As it is freely filtrated in the renal glomeruli, and not reabsorbed into circulation, therefore it may be used as a marker of glomerular filtration rate (GFR). We discuss clinical studies which were focused on the feasibility of plasma Cys C determination as a marker of GFR in various populations. Many of these studies suggest that plasma Cys C may be superior to plasma creatinine for the detection of patients with early decline in renal function. Recent data indicate, that Cys C may be a risk marker or factor of death or cardiovascular event in high-risk populations.
Symonides
Bartosz
B
Katedra i Klinika Chorób Wewnetrznych, Nadciśnienia Tetniczego i Angiologii Akademii Medycznej w Warszawie. bsymonid@amwaw.edu.pl
Wieteska
Maria
M
Bobilewicz
Dagna
D
D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015201:Meta-Analysis as Topic
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine