Two new cycloartane saponins from the roots of Astragalus membranaceus.
Two new cycloartane-type triterpenoid saponins were isolated from the roots of Astragalus membranaceus (FISCH.) BGE. (Leguminosae) cultivated in Kangwon province, Korea. These saponins were named astramembranosides A and B and were established to be cycloastragenol 6,25-di-O-beta-D-glucopyranoside (astramembranoside A) and cyclocanthogenin 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-xylopyranoside (astramembranoside B) on the basis of chemical and spectral evidence. In addition, 12 known saponins were also isolated from the same materials. Although cycloastragenol 3-O-xyloside and agroastragalosides I and II have already been isolated from A. membranaceus adventitious roots, these three saponins together with brachyoside B and azukisaponin V methyl ester were isolated for the first time from this plant.
Kim
Ju Sun
JS
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea.
Yean
Min-Hye
MH
Lee
Eun-Ju
EJ
Jung
Hye Sil
HS
Lee
Joo Young
JY
Kim
Yoon Jung
YJ
Kang
Sam Sik
SS
D027885:Astragalus propinquus / Q000737:chemistry*; D007723:Korea; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D012503:Saponins; D014315:Triterpenes; C525772:astramembranoside A; C525773:astramembranoside B; C085352:cycloartane