title: Rotavirus-induced seizures in childhood.
abstract: Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure, encephalopathy, and death. Symptoms may vary widely, however, and children can experience short afebrile convulsions as the only manifestation of rotavirus encephalopathy. We report 4 further cases of rotavirus-induced seizures with mild neurologic manifestations. The condition is reviewed and practical management strategies are suggested.
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. mddifazio@aol.com
authors.forename: Marc P
authors.initials: MP
authors.lastname: DiFazio
authors.forename: Loranee
authors.initials: L
authors.lastname: Braun
authors.forename: Scott
authors.initials: S
authors.lastname: Freedman
authors.forename: Patrick
authors.initials: P
authors.lastname: Hickey
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology; D004770:Enterovirus / Q000302:isolation & purification; D005243:Feces / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D010672:Phenytoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D012640:Seizures / Q000188:drug therapy / Q000821:virology*; D012720:Severity of Illness Index; D014839:Vomiting / Q000821:virology
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; C043114:fosphenytoin; D008140:Lorazepam