New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L.
Turmerin is a protein from Turmeric (Curcuma longa L.) with a relative molecular mass of 14 kDa. The protein inhibits the enzymatic activity and neutralizes the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase A2 (NV-PLA2) of cobra (Naja naja) venom at a 1:2.5 molar ratio of NV-PLA2:Turmerin. A Lineweaver-Burk plot indicates that Turmerin follows a linear mixed type of inhibition.
Chethankumar
Mukunda
M
Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India.
Srinivas
Leela
L
D000818:Animals; D030024:Curcuma / Q000737:chemistry; D004546:Elapid Venoms / Q000201:enzymology; D036341:Intercellular Signaling Peptides and Proteins; D007700:Kinetics; D008970:Molecular Weight; D010455:Peptides / Q000494:pharmacology*; D064801:Phospholipase A2 Inhibitors
D004546:Elapid Venoms; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D064801:Phospholipase A2 Inhibitors; C072268:turmerin