title: Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest.
abstract: Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC 50 values ranging from 0.19 to 0.63 microM.
authors.affiliation: Department of Chemistry, Virginia Polythecnic Institute, Blasburg, Virginia, USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Murphy
authors.forename: Peggie
authors.initials: P
authors.lastname: Brodie
authors.forename: Carla
authors.initials: C
authors.lastname: Slebodnick
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Chris
authors.initials: C
authors.lastname: Birkinshaw
authors.forename: Lucien M
authors.initials: LM
authors.lastname: Randrianjanaka
authors.forename: Rabodo
authors.initials: R
authors.lastname: Andriantsiferana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Karen
authors.initials: K
authors.lastname: TenDyke
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008270:Madagascar; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; C528677:malleastrone A; C528678:malleastrone B; C528679:malleastrone C