Novel approaches to the treatment of cachexia.
Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others. The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
Argilés
Josep M
JM
Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain. jargiles@ub.edu
López-Soriano
Francisco J
FJ
Busquets
Sílvia
S
D019167:Appetite Stimulants / Q000627:therapeutic use; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D019247:HIV Wasting Syndrome / Q000150:complications / Q000378:metabolism; D006333:Heart Failure / Q000150:complications / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000378:metabolism
D019167:Appetite Stimulants