title: A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16.
abstract: As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99 cM (log of the odds, LOD=3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD>1, approximately 95 cM) and Dutch (LOD>1, approximately 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90 cM (LOD=2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD=1.45 at 93 cM; German LOD=0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.
authors.affiliation: Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK. p.asherson@iop.kcl.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Asherson
authors.forename: K
authors.initials: K
authors.lastname: Zhou
authors.forename: R J L
authors.initials: RJ
authors.lastname: Anney
authors.forename: B
authors.initials: B
authors.lastname: Franke
authors.forename: J
authors.initials: J
authors.lastname: Buitelaar
authors.forename: R
authors.initials: R
authors.lastname: Ebstein
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: M
authors.initials: M
authors.lastname: Altink
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.forename: F
authors.initials: F
authors.lastname: Boer
authors.forename: K
authors.initials: K
authors.lastname: Brookes
authors.forename: C
authors.initials: C
authors.lastname: Buschgens
authors.forename: L
authors.initials: L
authors.lastname: Butler
authors.forename: D
authors.initials: D
authors.lastname: Cambell
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Christiansen
authors.forename: L
authors.initials: L
authors.lastname: Feldman
authors.forename: K
authors.initials: K
authors.lastname: Fleischman
authors.forename: E
authors.initials: E
authors.lastname: Fliers
authors.forename: R
authors.initials: R
authors.lastname: Howe-Forbes
authors.forename: A
authors.initials: A
authors.lastname: Goldfarb
authors.forename: A
authors.initials: A
authors.lastname: Heise
authors.forename: I
authors.initials: I
authors.lastname: Gabriëls
authors.forename: L
authors.initials: L
authors.lastname: Johansson
authors.forename: I
authors.initials: I
authors.lastname: Lubetzki
authors.forename: R
authors.initials: R
authors.lastname: Marco
authors.forename: S
authors.initials: S
authors.lastname: Medad
authors.forename: R
authors.initials: R
authors.lastname: Minderaa
authors.forename: F
authors.initials: F
authors.lastname: Mulas
authors.forename: U
authors.initials: U
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Mulligan
authors.forename: B
authors.initials: B
authors.lastname: Neale
authors.forename: F
authors.initials: F
authors.lastname: Rijsdijk
authors.forename: K
authors.initials: K
authors.lastname: Rabin
authors.forename: N
authors.initials: N
authors.lastname: Rommelse
authors.forename: V
authors.initials: V
authors.lastname: Sethna
authors.forename: J
authors.initials: J
authors.lastname: Sorohan
authors.forename: H
authors.initials: H
authors.lastname: Uebel
authors.forename: L
authors.initials: L
authors.lastname: Psychogiou
authors.forename: A
authors.initials: A
authors.lastname: Weeks
authors.forename: R
authors.initials: R
authors.lastname: Barrett
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Banaschewski
authors.forename: E
authors.initials: E
authors.lastname: Sonuga-Barke
authors.forename: J
authors.initials: J
authors.lastname: Eisenberg
authors.forename: I
authors.initials: I
authors.lastname: Manor
authors.forename: A
authors.initials: A
authors.lastname: Miranda
authors.forename: R D
authors.initials: RD
authors.lastname: Oades
authors.forename: H
authors.initials: H
authors.lastname: Roeyers
authors.forename: A
authors.initials: A
authors.lastname: Rothenberger
authors.forename: J
authors.initials: J
authors.lastname: Sergeant
authors.forename: H-C
authors.initials: HC
authors.lastname: Steinhausen
authors.forename: E
authors.initials: E
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Thompson
authors.forename: S V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015897:Comorbidity; D005060:Europe / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008126:Lod Score; D008297:Male; D015588:Observer Variation; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D035781:Siblings; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics