title: Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?
abstract: BACKGROUND
  Atopic dermatitis (AD) is a distressing disease associated with excoriations, pruritus, sleep disturbance, and elevation of serum total immunoglobulin E (IgE) levels.
  
  
  OBJECTIVE
  To evaluate whether serum IgE levels correlate with the symptomatology and plasma chemokine levels in children with AD.
  
  
  METHODS
  AD patients aged younger than 18 years were recruited from the pediatric dermatology clinic of a university teaching hospital, and the AD severity was evaluated using the SCORing Atopic Dermatitis (SCORAD) index. Concentrations of serum total IgE, eosinophil count, and plasma AD-associated chemokines [cutaneous T-cell-attracting cytokine (CTACK), thymus and activation-regulated chemokine (TARC)] were measured.
  
  
  RESULTS
  One hundred and seventeen Chinese children with AD (64 boys and 53 girls), with an age (mean +/- standard deviation) of 10.7 +/- 4.4 years, were recruited. Their overall SCORAD index (mean +/- standard deviation) was 51.1 +/- 22.8. The total serum IgE level divided by the age-specific upper limit (AE) correlated well with the extent and intensity of AD, except for oozing/crusting, which was significant only in males. There was a significant correlation between AE and pruritus or sleep loss only in females. Levels of IgE, CTACK, and TARC, and eosinophil count, differed significantly between patients with mild, moderate, and severe disease. AE correlated well with TARC (r = 0.50, P < 0.001) and eosinophil count (r = 0.41, P < 0.001), but not with CTACK (r = 0.11, P = 0.270). The prediction of moderate to severe eczema by AE gave an area under the receiver-operating characteristic curve of 0.76 (95% confidence interval, 0.65-0.86; P = 0.004). An optimum positive predictive value of 94.2% was achieved with a cut-off point of AE of 2.95, sensitivity of 75.0%, and specificity of 66.7%.
  
  
  CONCLUSIONS
  AE correlates significantly with various objective clinical scores and chemokine markers of AD, and is a useful indicator for predicting moderate to severe AD in children.
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China. ehon@hotmail.com
authors.forename: Kam-Lun Ellis
authors.initials: KL
authors.lastname: Hon
authors.forename: Man-Ching Adrian
authors.initials: MC
authors.lastname: Lam
authors.forename: Ting-Fan
authors.initials: TF
authors.lastname: Leung
authors.forename: Kin-Yee
authors.initials: KY
authors.lastname: Wong
authors.forename: Chung-Mo
authors.initials: CM
authors.lastname: Chow
authors.forename: Tai-Fai
authors.initials: TF
authors.lastname: Fok
authors.forename: Pak-Cheung
authors.initials: PC
authors.lastname: Ng
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D054414:Chemokine CCL17 / Q000097:blood; D054425:Chemokine CCL27 / Q000097:blood; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood* / Q000150:complications / Q000473:pathology; D004804:Eosinophils; D005260:Female; D006801:Humans; D007118:Immunoassay; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D011537:Pruritus / Q000209:etiology; D012372:ROC Curve; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D054414:Chemokine CCL17; D054425:Chemokine CCL27; D007073:Immunoglobulin E