Nod-like receptors: cytosolic watchdogs for immunity against pathogens.
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both the extracellular and intracellular microenvironment. Repressing and de-repressing the cytosolic surveillance machinery contributes to vital immune homeostasis and protective responses within specific tissues. Conversely, defective biology of NLR drives the development of recurrent infectious, autoimmune and/or inflammatory diseases by failing to mount barrier functions against pathogens, to tolerate commensals, and/or to instruct the adaptive immune response against microbes. Better decoding microbial strategies that are evolved to circumvent NLR sensing will provide clues for the development of rational therapies aimed at curing and/or preventing common and emerging immunopathologies.
Sirard
Jean-Claude
JC
NSERM, U801, Institut Pasteurde Lille, Université Lille 2, Lille, France.
Vignal
Cécile
C
Dessein
Rodrigue
R
Chamaillard
Mathias
M
D000818:Animals; D003600:Cytosol / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D053472:Nod Signaling Adaptor Proteins