title: An attempt to correlate a "Multidimensional Geriatric Assessment" (MGA), treatment assignment and clinical outcome in elderly cancer patients: results of a phase II open study.
abstract: OBJECTIVE
  To establish a correlation between a specific MGA category, an appropriate preventively established treatment and clinical outcome in a population of elderly cancer patients. The ultimate goal was to verify whether the appropriate treatment given to elderly cancer patients according to their MGA category could translate into a better clinical outcome assessed as clinical response and toxicity, i.e whether this process might achieve a clinically meaningful impact.
  
  
  METHODS
  We carried out a phase II open, prospective non-randomized study in 75 elderly cancer patients (lung, head and neck, colorectal, gynecologic and breast) hospitalized at the Department of Medical Oncology, University of Cagliari, Italy. All patients underwent MGA evaluation and were assigned to three different categories: fit, intermediate and frail. Thereafter, an appropriate preventively established treatment was administered and the clinical outcome was assessed. The clinical outcome after 3 month treatment was defined on the basis of objective clinical response and toxicity. The difference of clinical outcome in the MGA categories was assessed by ANOVA test. Moreover, the correlation between MGA category and the clinical outcome (clinical response and toxicity) was assessed by Spearman's correlation test.
  
  
  RESULTS
  A better clinical response was observed in fit patients as compared both to intermediate and frail patients. Treatment toxicity was comparable in the different MGA categories. The correlation analysis between MGA category, clinical response to treatment and toxicity showed that there was a significant direct correlation with clinical response and no correlation with toxicity. Overall, the regression analysis showed that MGA was predictive of clinical outcome, in the sense that it is truly predictive for clinical response and no predictive for toxicity.
  
  
  CONCLUSIONS
  Our study demonstrates that the MGA, although time-consuming, is a useful and cost-benefit effective tool to appropriately select elderly cancer patients to be treated effectively in terms of a survival advantage and those who would benefit mainly in terms of improvement of quality of life. Moreover, the treatment preventively established for each MGA category was shown to be adequate and accomplished the most appropriate performances in terms of effectiveness and toxicity.
authors.affiliation: Department of Medical Oncology, University of Cagliari, Cagliari, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Massa
authors.forename: Clelia
authors.initials: C
authors.lastname: Madeddu
authors.forename: Giorgio
authors.initials: G
authors.lastname: Astara
authors.forename: Michela
authors.initials: M
authors.lastname: Pisano
authors.forename: Carla
authors.initials: C
authors.lastname: Spiga
authors.forename: Francesca Maria
authors.initials: FM
authors.lastname: Tanca
authors.forename: Eleonora
authors.initials: E
authors.lastname: Sanna
authors.forename: Ilaria
authors.initials: I
authors.lastname: Puddu
authors.forename: Elena
authors.initials: E
authors.lastname: Patteri
authors.forename: Giovanna
authors.initials: G
authors.lastname: Lamonica
authors.forename: Laura
authors.initials: L
authors.lastname: Deiana
authors.forename: Federica
authors.initials: F
authors.lastname: Saba
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mantovani
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000523:psychology / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome