Goserelin versus leuprolide before hysterectomy for uterine fibroids.
OBJECTIVE
To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri.


METHODS
A randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose.


RESULTS
A total of 34 women randomized to the goserelin group and 31 women to the leuprolide group were available for analysis. Preoperative hemoglobin level (P=0.89), operative blood loss (P=0.72), and operating time (P=0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P=0.003), but blood transfusion requirement was not different between the groups (P=1.0). Other outcomes and side effects of the drugs were similar.


CONCLUSIONS
Goserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.
Lim
Soo Soo
SS
Department of Obstetrics and Gynecology, University of Malaya, Kuala Lumpur, Malaysia.
Sockalingam
Jayanthi K
JK
Tan
Peng Chiong
PC
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D017273:Goserelin / Q000008:administration & dosage*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000473:pathology / Q000628:therapy*; D016729:Leuprolide / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy*
D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D016729:Leuprolide