title: [Basic and clinical aspects of calcimimetics. Cinacalcet, effect and mechanisms of action].
abstract: Calcimimetics drug such as cinacalcet suppress the secretion of parathyroid hormone by sensitizing parathyroid calcium receptors to extracellular ionized calcium. Standard treatment for secondary hyperparathyroidism is associated with the risk of hypercalcemia, but cinacalcet don't induce elevation of serum calcium. And it is reported that cinacalcet attenuates parathyroid hyperplasia and it effects on other organs.
authors.affiliation: Toranomon Hospital, Nephrology Center, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D000069449:Cinacalcet; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy; D009281:Naphthalenes / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D010280:Parathyroid Glands / Q000187:drug effects; D044169:Receptors, Calcium-Sensing / Q000037:antagonists & inhibitors*
chemical_list: D009281:Naphthalenes; D044169:Receptors, Calcium-Sensing; D000069449:Cinacalcet