title: Risk factors for surgical-site infections in head and neck cancer surgery.
abstract: OBJECTIVE
  The aim of this study was to identify risk factors for surgical-site infections (SSIs) in patients with head and neck cancer submitted to major clean-contaminated surgery.
  
  
  METHODS
  This is a prospective study conducted in a tertiary cancer center hospital.
  
  
  METHODS
  This study includes 258 patients submitted to a major clean-contaminated head and neck oncologic surgery.
  
  
  RESULTS
  The overall SSI rate was 38.8%. The univariate analysis showed the following significant risk factors: race, tobacco consumption, clinical stage, comorbidities, time duration of the surgical procedure, and flap reconstruction. The final model by logistic regression identified the following independent predictors for SSI: tobacco consumption (odds ratio [OR] = 2.96), presence of metastatic lymph nodes (OR = 2.05), flap reconstruction (OR = 2.20), and antimicrobial prophylaxis exceeding 48 hours (OR=1.89).
  
  
  CONCLUSIONS
  The high-risk patients for SSI in head and neck oncologic surgery were those with cancer at advanced stages, those who were smokers, those presenting comorbidities, those who needed major reconstruction of the surgical wound, or those who were submitted to inadequate antibiotic prophylaxis.
authors.affiliation: Infectious Diseases Service, Hospital do Câncer A.C.Camargo, São Paulo, Brazil. scih@hcsancer.org.br
authors.forename: Carlos Jorge
authors.initials: CJ
authors.lastname: Lotfi
authors.forename: Rita de Cássia
authors.initials: Rde C
authors.lastname: Cavalcanti
authors.forename: Adriana Maria
authors.initials: AM
authors.lastname: Costa e Silva
authors.forename: Maria do Rosário Dias de Oliveira
authors.initials: Mdo R
authors.lastname: Latorre
authors.forename: Karina de Cássia Braga
authors.initials: Kde C
authors.lastname: Ribeiro
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Carvalho
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents