Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
BACKGROUND
It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated


RESULTS
A total of 186 consecutive male CAD patients participated in the study and were categorized into quartiles based on their total adiponectin level. The interquartile cut-off points were 4.0, 5.5 and 7.0 microg/ml. The HMW adiponectin levels were significantly lower in the quartile of lower total adiponectin levels both in non-diabetic and diabetic patients. In contrast, low molecular weight adiponectin levels (which were calculated as the Total - HMW) were constant. In univariate analysis, total adiponectin correlated negatively with body mass index and hemoglobin (Hb) A1c, and HMW adiponectin correlated negatively with HbA1c in non-diabetic patients. On the other hand, total and HMW adiponectin correlated positively with high-density lipoprotein-cholesterol (HDL-C) in diabetic patients. Multiple regression analysis revealed that HMW adiponectin correlated negatively with HbA1c in non-diabetic patients, and total and HMW adiponectin correlated positively with HDL-C in diabetic patients.


CONCLUSIONS
Change in the HMW isoform reflects a change in total adiponectin level. Measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in CAD patients.
Komura
Noriyuki
N
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Kihara
Shinji
S
Sonoda
Mina
M
Kumada
Masahiro
M
Fujita
Koichi
K
Hiuge
Aki
A
Okada
Takuya
T
Nakagawa
Yasuhiko
Y
Tamba
Sachiko
S
Kuroda
Yohei
Y
Hayashi
Noriyuki
N
Sumitsuji
Satoru
S
Kawamoto
Toshiharu
T
Matsumoto
Satoru
S
Ouchi
Noriyuki
N
Arita
Yukio
Y
Okamoto
Yoshihisa
Y
Shimomura
Iichiro
I
Funahashi
Tohru
T
Matsuzawa
Yuji
Y
D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D050197:Atherosclerosis / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL; D003324:Coronary Artery Disease / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012044:Regression Analysis; D012307:Risk Factors
D052242:Adiponectin; D008076:Cholesterol, HDL; D006454:Hemoglobins