5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity.
A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.
Watanabe
Kazutoshi
K
Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
Morinaka
Yasuhiro
Y
Hayashi
Yoshio
Y
Shinoda
Masaki
M
Nishi
Hiroyoshi
H
Fukushima
Nobuko
N
Watanabe
Toshiaki
T
Ishibashi
Akira
A
Yuki
Satoshi
S
Tanaka
Masahiko
M
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D048288:Imidazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000975:Antioxidants; D016166:Free Radical Scavengers; D048288:Imidazolines