[Action of ACTH fragment on the rates aggressive behavior and the distribution of transmitter amino acids in the brain structures].
Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency to an increase of the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation. It is generally accepted that ACTH fragments activate limbic syctem and regulate instinctive - motivated behavior. The neuroactive properties of short fragments of ACTH (4-7) are considered to be the peptides of memory and behavior. The aim of the study was to investigate the influence of ACTH fragments on aggressive behavior of naturally aggressive rats. Two-fold intraperitoneal introduction of ACTH fragments provoke a change in the animals behavior -rats become non-agressive. Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency of increase the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation. The results obtained enable to conclude that fragment 4-7 of ACTH has an influence on aggressive behavior.
Vasadze
L
L
Center of Radiobiology and Radiation Ecology.
Petriashvili
E
E
Museliani
T
T
Nikolaishvili
M
M
Djariashvili
T
T
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D000324:Adrenocorticotropic Hormone