title: An analysis of risk factors for asymptomatic cerebral infarction.
abstract: OBJECTIVE
  The aim of this study is to identify risk factors for asymptomatic cerebral infarction (ACI) in the general Japanese population.
  
  
  METHODS
  A total of 634 subjects (272 men aged 55.4+/-8.8 years and 362 women aged 55.2+/-8.5 years) who visited the Health Management Center at Aoyama Hospital (Tokyo, Japan) from January 2004 through January 2005 for an annual brain dry dock examination were analyzed. We evaluated 21 risk factors for ACI by multivariate logistic regression analysis.
  
  
  RESULTS
  Abnormal or potentially abnormal conditions were detected in 258 subjects (40.7% of all subjects who had an annual check-up program for brain disease). The most frequent abnormal finding was ACI, which was observed in 208 subjects. The significant risk factors for ACI, as determined by multivariate logistic analysis, were age (P <0.01), hypertension (P <0.01), and hypertensive vascular changes in the fundus (P <0.05).
  
  
  CONCLUSIONS
  The hypertensive vascular abnormalities in the fundus might be a risk factor for ACI independent of age and hypertension.
authors.affiliation: Health Management Center, Aoyama Hospital, Mutual Benefit Association for Tokyo Metropolitan Government Employees, Tokyo. toshiga@imcj.hosp.go.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shiga
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Owada
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hoshino
authors.forename: Hikaru
authors.initials: H
authors.lastname: Nagahara
authors.forename: Keiko
authors.initials: K
authors.lastname: Shiratori
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002544:Cerebral Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D015995:Prevalence; D012161:Retinal Artery; D012307:Risk Factors