title: A note on difficult structure alignment problems.
abstract: Progress in structural biology depends on several key technologies. In particular tools for alignment and superposition of protein structures are indispensable. Here we describe the use of the TopMatch web service, an effective computational tool for protein structure alignment, for the visualization of structural similarities, and for highlighting relationships found in protein classifications. We provide several instructive examples.
  
  
  BACKGROUND
  TopMatch is available as a public web service at http://services.came.sbg.ac.at.
authors.affiliation: Center of Applied Molecular Engineering, Division of Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria. sippl@came.sbg.ac.at
authors.forename: Manfred J
authors.initials: MJ
authors.lastname: Sippl
authors.forename: Markus
authors.initials: M
authors.lastname: Wiederstein
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D020407:Internet; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software
chemical_list: D011506:Proteins