Serotonin syndrome after concomitant treatment with linezolid and meperidine.
Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors. Meperidine blocks the neuronal reuptake of serotonin. Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described. We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.
Das
Prabodh K
PK
Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Warkentin
Dawn I
DI
Hewko
Robert
R
Forrest
Donna L
DL
D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy; D000069349:Linezolid; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects*; D023303:Oxazolidinones / Q000008:administration & dosage / Q000009:adverse effects*; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000150:complications
D000081:Acetamides; D023303:Oxazolidinones; D008614:Meperidine; D000069349:Linezolid