title: [Clinical value, diagnosis and treatment of thyroid differentiated microcarcinoma].
abstract: Results of surgical treatment of 240 patients with thyroid differentiated microcarcinoma (less 1 cm in diameter) are analyzed. Papillary and follicular tumor was diagnosed at 212 (88.3%) and 28 (11.7%) respectively. Microcarcinoma had no clinical symptoms in majority cases. In some cases microcarcinoma had aggressive clinical course: at 10.8% patients the tumor was extended beyond the bounds of thyroid capsule (T3), at 2.1% patients the primary symptoms of disease were metastases into cervical nodes. Long-term results of surgical treatment were followed-up until 25 years after surgery, 5-year survival rate and recurrence-free period were 99.5 and 99% respectively. Recurrence of tumor occurred at 2 (0.8%) patients with initial III and IVA stages of disease despite previous radical operation, one of them died in 4 years after surgery. Microcarcinoma is regarded as early stage of thyroid gland cancer. Ultrasonic examination and fine-needle biopsy permit to diagnose timely this malignant tumor.
authors.forename: A M
authors.initials: AM
authors.lastname: Shulutko
authors.forename: V I
authors.initials: VI
authors.lastname: Semikov
authors.forename: V I
authors.initials: VI
authors.lastname: Griaznov
authors.forename: N G
authors.initials: NG
authors.lastname: Chakvetadze
authors.forename: S V
authors.initials: SV
authors.lastname: Popov
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods*; D013997:Time Factors