title: Treatment of infected hip arthroplasty with antibiotic-impregnated calcium hydroxyapatite.
abstract: We reviewed the treatment of infected hip arthroplasty with antibiotic-impregnated calcium hydroxyapatite (CHA) ceramic blocks. Seven consecutive patients consisting of 2 men and 5 women with an average age of 65 years were followed up for an average of 5.0 years. All patients received resection arthroplasty and thorough debridement, followed by implantation of antibiotic-impregnated CHA ceramic. Two-stage revision was performed in all patients. There was no evidence of a recurrent infection in 6 patients. The remaining one patient underwent an additional debridement 2 years after the second stage. This patient was free of infection at the time of the latest follow-up. Antibiotic-impregnated CHA ceramic is thus considered to be an excellent drug delivery system for the infected hip arthroplasty.
authors.affiliation: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sudo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Aki
authors.initials: A
authors.lastname: Fukuda
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002516:Ceramics; D003646:Debridement; D016503:Drug Delivery Systems; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D017886:Durapatite