Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride.
The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedded tablets. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and polymers used in the study. Statistical analysis (ANOVA) showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 12 h from optimized formulations was observed.
Patra
Chinam Niranjan
CN
P. G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India. patro_niranjan@rediffmail.com
Kumar
Arethi Bharani
AB
Pandit
Hemant Kumar
HK
Singh
Satya Prakash
SP
Devi
Meduri Vimala
MV
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D007700:Kinetics; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D011433:Propranolol / Q000737:chemistry*; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; C496966:Eudragit RSPO; D011108:Polymers; D011109:Polymethacrylic Acids; C013517:ethyl cellulose; D002482:Cellulose; D013213:Starch; C048390:sodium starch glycolate; D011433:Propranolol