Plasmid-Borne erm(T) from invasive, macrolide-resistant Streptococcus pyogenes strains.
Twenty-three isolates of group A streptococci (GAS) recovered from population-based invasive GAS surveillance in the United States were erythromycin resistant, inducibly clindamycin resistant, and lacked known macrolide resistance determinants. These 23 isolates, representing four different clones, contained a broad-host-range plasmid carrying the erm(T) methylase gene, which has not been detected in GAS previously.
Woodbury
Robyn L
RL
Division of Bacterial Diseases, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Klammer
Kathryn A
KA
Xiong
Yang
Y
Bailiff
Timothy
T
Glennen
Anita
A
Bartkus
Joanne M
JM
Lynfield
Ruth
R
Van Beneden
Chris
C
Beall
Bernard W
BW
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D011159:Population Surveillance; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014481:United States
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin; D008780:Methyltransferases