Participation of kallikrein-kinin system in different pathologies.
The general description of kinins refers to these peptides as molecules involved in vascular tone regulation and inflammation. Nevertheless, in the last years a series of evidences has shown that local hormonal systems, such as the kallikrein-kinin system, may be differently regulated and are of pivotal importance to pathophysiological control. The combined interpretations of many recent studies allow us to conclude that the kallikrein-kinin system plays broader and richer roles than those classically described until recently. In this review, we report findings concerning the participation of the kallikrein-kinin system in inflammation, cancer, and in pathologies related to cardiovascular, renal and central nervous systems.
Costa-Neto
Claudio M
CM
Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. claudio@fmrp.usp.br <claudio@fmrp.usp.br>
Dillenburg-Pilla
Patrícia
P
Heinrich
Tassiele A
TA
Parreiras-e-Silva
Lucas T
LT
Pereira
Marilia G A G
MG
Reis
Rosana I
RI
Souza
Pedro P C
PP
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology*; D002493:Central Nervous System Diseases / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007674:Kidney Diseases / Q000209:etiology*; D009369:Neoplasms / Q000209:etiology*