Age-specific modulation of genes involved in lipid and cholesterol homeostasis by dietary zinc.
The association between zinc status and lipid-related metabolic diseases, such as coronary heart disease, has produced conflicting results. Since heterogeneity of the adult population-or inter-individual variation-may impact on response to dietary zinc, nutritional genomic approaches were used to investigate the impact of age on zinc-regulated gene expression in lymphocytes. Many genes involved in lipid and cholesterol homeostasis were found to be differentially regulated by zinc in an age-dependent manner. Additionally, the individual genes affected and the extent of differential regulation varied with respect to donor age, suggesting that the age-related phenotype may alter zinc action.
Mazzatti
Dawn J
DJ
Unilever Corporate Research, Sharnbrook, United Kingdom. Dawn.Mazzatti@unilever.com
Mocchegiani
Eugenio
E
Powell
Jonathan R
JR
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects / Q000235:genetics*; D002784:Cholesterol / Q000378:metabolism*; D004032:Diet; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics*; D008297:Male; D015032:Zinc / Q000494:pharmacology*
D002784:Cholesterol; D015032:Zinc