[Clinical observation on treatment of male infertility with positive antisperm antibody by self-formulated Xiaokang Zhongzi Recipe].
OBJECTIVE
To observe the therapeutic effect of self-formulated Xiaokang Zhongzi Recipe (XZR) in treating male infertility with positive antisperm antibody (AsAb).


METHODS
One hundred and ten male infertility patients with positive AsAb were randomly assigned, according to randomized digital table, to the trial group treated with XZR, and the control group, treated with prednisone, 55 in each group. Clinical therapeutic effect and adverse reactions of the drugs were observed after 3 months of treatment.


RESULTS
In the trial group after treatment, 38 patients (69.1%) were cured, 14 (25.4%) improved and 3 treated in vain (5.5%, including 2 dropped out). While in the control group, the corresponding numbers were 12 (21.8%), 11 (20.0%) and 32 (58.2%, including 4 dropped out, 20 remained AsAb positive and 8 with AsAb reverted to positive after negative conversion). The negative conversion rate and average negative conversion time in the trial group and the control group were respectively 94.5%, (45 +/- 14) days and 41.8%, (62 +/- 21) days. Significant difference between the two groups was shown in therapeutic effectiveness and average negative conversion time (P < 0.01). Adverse reactions occurred in 3 cases (5.5%) in the trial group and 8 (14.5%) in the control group.


CONCLUSIONS
XZR is better than prednisone in treating male infertility with positive AsAb, and with fewer and milder adverse reactions.
Qi
Tian-shou
TS
Yangzhou Maternity and Child Healthcare Hospital, Jiangsu. yzqts@126.com
Li
Guo-qing
GQ
Xu
Gui-jiang
GJ
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D008297:Male; D008517:Phytotherapy; D013094:Spermatozoa / Q000187:drug effects* / Q000276:immunology; D016896:Treatment Outcome; D055815:Young Adult
D001323:Autoantibodies; D004365:Drugs, Chinese Herbal; C533487:xiaokang zhongzi