Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings.
Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
Choi
Suk Jin
SJ
Department of Pathology, Inha University College of Medicine, 7-206 Shinheung- dong 3 ga, Joong-gu, Incheon 400-711, Korea.
Kim
Joon Mee
JM
Han
Jee Young
JY
Ahn
Seung Ik
SI
Kim
Jin-Soo
JS
Kim
Lucia
L
Park
In Suh
IS
Chu
Young Chae
YC
D000369:Aged, 80 and over; D019002:CD56 Antigen / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D002864:Chromogranins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry / Q000473:pathology*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
D019002:CD56 Antigen; D002864:Chromogranins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase