Should Anacardium humile St. Hil be used as an antiulcer agent? A scientific approach to the traditional knowledge.
The crude methanolic extract (ME) obtained from the leaves of Anacardium humile was evaluated orally at doses of 250-500-1000 mg/kg on gastric lesion on ethanol and piroxicam induced gastric lesions in rodents. All the tested doses significantly inhibited gastric lesions by 56 to 100%. These results seems to support the traditional use of this species in the treatment of gastric diseases.
Luiz-Ferreira
Anderson
A
Departamento de Fisiologia e Biofísica, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. a021709@dac.unicamp.br
Cola-Miranda
Maira
M
Barbastefano
Victor
V
Hiruma-Lima
Clélia Akiko
CA
Vilegas
Wagner
W
Souza Brito
Alba Regina Monteiro
AR
D031021:Anacardium; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010894:Piroxicam; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D010894:Piroxicam; D000431:Ethanol