Can ABO-incompatible organ transplantation pave the way for clinical xenotransplantation?
Because of the apparent mechanistic similarities between antibody-mediated rejection of ABO-incompatible organ allografts and vascularized xenografts, there is hope that strategies to enable transplantation across the ABO barrier may also be effective in curbing xenograft rejection. This paper discusses the molecular similarities and differences between an ABO-incompatible allograft and a porcine xenograft in terms of their interactions with the immune system.
Holgersson
Jan
J
Division of Clinical Immunology, Karolinska Institute, Karolinska University; Hospital, Huddinge, Stockholm, Sweden. jan.holgersson@ki.se
D000017:ABO Blood-Group System; D000818:Animals; D001787:Blood Group Incompatibility; D001803:Blood Transfusion; D002241:Carbohydrates / Q000737:chemistry; D003167:Complement Activation; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D015398:Signal Transduction; D013552:Swine; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous / Q000379:methods*; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D002241:Carbohydrates