title: High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy.
abstract: OBJECTIVE
  To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma after gastrectomy.
  
  
  METHODS
  The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index (BMI), anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.
  
  
  RESULTS
  The prevalence of osteoporosis in the lumbar spine was 38.3% (male, 28.9%; female, 54.0%), and 15.0% in the femoral neck (male, 10.8%; female, 22.0%). The vertebral deformity rate was 46.6% (male, 43.4%; female, 52.0%). Age, BMI and hemoglobin correlated with BMD (P < 0.01). In males, anemia and age > 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.
  
  
  CONCLUSIONS
  The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.
authors.affiliation: Department of Surgery, Korea Cancer Center Hospital, Gongneung-dong 215, Nowon-gu, Seoul 139-706, Korea.
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lim
authors.forename: Sang Bum
authors.initials: SB
authors.lastname: Kim
authors.forename: Ho-Yoon
authors.initials: HY
authors.lastname: Bang
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.forename: Jong-Inn
authors.initials: JI
authors.lastname: Lee
mesh_terms: D015502:Absorptiometry, Photon; D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D001416:Back Pain / Q000503:physiopathology; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010024:Osteoporosis / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*