title: [Cytomegalovirus disease in HIV-1 infected Chilean children].
abstract: Cytomegalovirus (CMV) is a frequent opportunistic infection in human immunodeficiency virus type 1 (HIV-1) infected children associated with significant morbidity and mortality. The aim of this study was to determine the frequency and impact of CMV disease in a prospective ly followed cohort of HIV-1 infected Chilean children. CMV disease was diagnosed in 28 out of 222 HIV infected children (12.6%); 92% of them were classified in category C and 61% in category 3 (CDC, 1994). Lung disease was the most common manifestation (25 children). Samples were obtained from the respiratory tract, blood, urine and tissue biopsies. Shell vial for CMV early antigen detection was the most commonly used diagnostic technique (20/ 28). All patients were treated with iv.ganciclovir and two children died during the CMV episode. The mean survival time for the remaining children is currently 42 months.
  
  
  CONCLUSIONS
  CMV disease was frequent and caused mortality in HIV-1 infected Chilean children. Early diagnosis and treatment are key for clinical success.
authors.affiliation: Hospital Dr. Sótero del Río, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Anamaría
authors.initials: A
authors.lastname: Peña
authors.forename: Carmen
authors.initials: C
authors.lastname: Larrañaga
authors.forename: Vivian
authors.initials: V
authors.lastname: Luchsinger
authors.forename: Julia
authors.initials: J
authors.lastname: Villarroel
authors.forename: Ana
authors.initials: A
authors.lastname: Chávez
authors.forename: Elba
authors.initials: E
authors.lastname: Wu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015774:Ganciclovir / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir