title: Daptomycin treatment failure for vancomycin-resistant Enterococcus faecium infective endocarditis: impact of protein binding?
authors.forename: Brian S
authors.initials: BS
authors.lastname: Schwartz
authors.forename: Penny D
authors.initials: PD
authors.lastname: Ngo
authors.forename: B Joseph
authors.initials: BJ
authors.lastname: Guglielmo
mesh_terms: D000368:Aged; D017576:Daptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D016984:Enterococcus faecium / Q000187:drug effects / Q000378:metabolism; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D008297:Male; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D017211:Treatment Failure; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use*; D020713:Vancomycin Resistance / Q000187:drug effects / Q000502:physiology*
chemical_list: D014640:Vancomycin; D017576:Daptomycin