title: Should Anacardium humile St. Hil be used as an antiulcer agent? A scientific approach to the traditional knowledge.
abstract: The crude methanolic extract (ME) obtained from the leaves of Anacardium humile was evaluated orally at doses of 250-500-1000 mg/kg on gastric lesion on ethanol and piroxicam induced gastric lesions in rodents. All the tested doses significantly inhibited gastric lesions by 56 to 100%. These results seems to support the traditional use of this species in the treatment of gastric diseases.
authors.affiliation: Departamento de Fisiologia e Biofísica, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. a021709@dac.unicamp.br
authors.forename: Anderson
authors.initials: A
authors.lastname: Luiz-Ferreira
authors.forename: Maira
authors.initials: M
authors.lastname: Cola-Miranda
authors.forename: Victor
authors.initials: V
authors.lastname: Barbastefano
authors.forename: Clélia Akiko
authors.initials: CA
authors.lastname: Hiruma-Lima
authors.forename: Wagner
authors.initials: W
authors.lastname: Vilegas
authors.forename: Alba Regina Monteiro
authors.initials: AR
authors.lastname: Souza Brito
mesh_terms: D031021:Anacardium; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010894:Piroxicam; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D010894:Piroxicam; D000431:Ethanol