title: Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta.
abstract: Eutherian placenta, an organ that emerged in the course of mammalian evolution, provides essential architecture, the so-called feto-maternal interface, for fetal development by exchanging nutrition, gas and waste between fetal and maternal blood. Functional defects of the placenta cause several developmental disorders, such as intrauterine growth retardation in humans and mice. A series of new inventions and/or adaptations must have been necessary to form and maintain eutherian chorioallantoic placenta, which consists of capillary endothelial cells and a surrounding trophoblast cell layer(s). Although many placental genes have been identified, it remains unknown how the feto-maternal interface is formed and maintained during development, and how this novel design evolved. Here we demonstrate that retrotransposon-derived Rtl1 (retrotransposon-like 1), also known as Peg11 (paternally expressed 11), is essential for maintenance of the fetal capillaries, and that both its loss and its overproduction cause late-fetal and/or neonatal lethality in mice.
authors.affiliation: Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sekita
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Wagatsuma
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ono
authors.forename: Masayo
authors.initials: M
authors.lastname: Kagami
authors.forename: Noriko
authors.initials: N
authors.lastname: Wakisaka
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hino
authors.forename: Rika
authors.initials: R
authors.lastname: Suzuki-Migishima
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohda
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ogura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ogata
authors.forename: Minesuke
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kaneko-Ishino
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Ishino
mesh_terms: D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D015415:Biomarkers / Q000378:metabolism; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D033481:Chromosomes, Mammalian; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D007150:Immunohistochemistry; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D035683:MicroRNAs / Q000378:metabolism; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010375:Pedigree; D010920:Placenta / Q000502:physiology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000502:physiology*; D018626:Retroelements / Q000502:physiology*; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011257:Pregnancy Proteins; D018626:Retroelements; C526773:Rtl1 protein, mouse