Microstimulation and architectonics of frontoparietal cortex in common marmosets (Callithrix jacchus).
We investigated the organization of frontoparietal cortex in the common marmoset (Callithrix jacchus) by using intracortical microstimulation and an architectonic analysis. Primary motor cortex (M1) was identified as an area that evoked visible movements at low levels of electric current and had a full body representation of the contralateral musculature. Primary motor cortex represented the contralateral body from hindlimb to face in a mediolateral sequence, with individual movements such as jaw and wrist represented in multiple nearby locations. Primary motor cortex was coextensive with an agranular area of cortex marked by a distinct layer V of large pyramidal cells that gradually decreased in size toward the rostral portion of the area and was more homogenous in appearance than other New World primates. In addition to M1, stimulation also evoked movements from several other areas of frontoparietal cortex. Caudal to primary motor cortex, area 3a was identified as a thin strip of cortex where movements could be evoked at thresholds similar to those in M1. Rostral to primary motor cortex, supplementary motor cortex and premotor areas responded to higher stimulation currents and had smaller layer V pyramidal cells. Other areas evoking movements included primary somatosensory cortex (area 3b), two lateral somatosensory areas (areas PV and S2), and a caudal somatosensory area. Our results suggest that frontoparietal cortex in marmosets is organized in a similar fashion to that of other New World primates.
Burish
Mark J
MJ
Neuroscience Graduate Program and Medical Scientist Training Program, Vanderbilt University, Nashville, Tennessee 37240, USA.
Stepniewska
Iwona
I
Kaas
Jon H
JH
D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002144:Callithrix / Q000033:anatomy & histology* / Q000502:physiology; D004525:Efferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology* / Q000502:physiology; D009068:Movement / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000502:physiology; D011323:Primates / Q000033:anatomy & histology / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology* / Q000502:physiology; D013045:Species Specificity; D014110:Touch / Q000502:physiology