Intraflagellar transport motors in cilia: moving along the cell's antenna.
Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
Scholey
Jonathan M
JM
Department of Molecular and Cell Biology, University of California, Davis, Davis, CA 95616, USA. jmscholey@ucdavis.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002696:Chlamydomonas / Q000378:metabolism / Q000648:ultrastructure; D002923:Cilia / Q000378:metabolism* / Q000648:ultrastructure; D004398:Dyneins / Q000502:physiology; D005407:Flagella / Q000378:metabolism* / Q000648:ultrastructure; D016547:Kinesins / Q000502:physiology; D008954:Models, Biological
D004398:Dyneins; D016547:Kinesins