Pinacidil relaxing effect on phenylephrine-precontracted guinea pig aorta was abolished by pretreatment with 17-beta-estradiol.
In this paper we have shown that estrogen selectively diminishes relaxing effects of pinacidil, but not other activators of ATP-sensitive K(+) channels, on guinea pig aortic rings precontracted by phenylephrine.
Kocic
I
I
Gruchala-Niedoszytko
M
M
D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D006168:Guinea Pigs; D010656:Phenylephrine / Q000494:pharmacology; D020110:Pinacidil / Q000494:pharmacology*
D010656:Phenylephrine; D004958:Estradiol; D020110:Pinacidil