Ac-ing the clock.
Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of the relevant E3 ligases are known. In addition, Hirayama et al. recently identified acetylation as a clock regulatory mechanism.
Sehgal
Amita
A
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. amita@mail.med.upenn.edu
D000107:Acetylation; D000123:Acetyltransferases / Q000502:physiology; D000818:Animals; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000502:physiology*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D015534:Trans-Activators / Q000378:metabolism*
D015534:Trans-Activators; D000123:Acetyltransferases; D056926:CLOCK Proteins