title: [Effect of HMME-PDT on hyperplastic scar in rabbit ear model].
abstract: OBJECTIVE
  To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.
  
  
  METHODS
  The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.
  
  
  RESULTS
  Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.
  
  
  CONCLUSIONS
  HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.
authors.affiliation: Department of Laser Medicine, Chinese PLA Hospital, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Shao-ran
authors.initials: SR
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Dong-wen
authors.initials: DW
authors.lastname: Shi
authors.forename: Lu-yong
authors.initials: LY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000628:therapy*; D004423:Ear / Q000473:pathology; D005260:Female; D006415:Hematoporphyrins / Q000494:pharmacology*; D008297:Male; D010778:Photochemotherapy; D011817:Rabbits
chemical_list: D006415:Hematoporphyrins; C494379:hematoporphyrin monomethyl ether