Improving outcomes of acute invasive Aspergillus rhinosinusitis in patients with hematologic malignancies or aplastic anemia: the role of voriconazole.
We evaluated the outcomes of patients with hematologic diseases diagnosed with acute invasive Aspergillus rhinosinusitis comparing a group of patients diagnosed after voriconazole was available at our center with a historical group of patients diagnosed before voriconazole was available. Voriconazole use was associated with a decrease in mortality and earlier clinical response.
Girmenia
Corrado
C
Pizzarelli
Giampaolo
G
Pozzi
Emanuela
E
Cimino
Giuseppe
G
Gentile
Giuseppe
G
Martino
Pietro
P
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000382:microbiology* / Q000628:therapy*; D001228:Aspergillosis / Q000175:diagnosis* / Q000628:therapy; D002648:Child; D015331:Cohort Studies; D005260:Female; D019337:Hematologic Neoplasms / Q000382:microbiology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole