title: Circulating antioxidant defences are decreased in healthy people after a high-fat meal.
abstract: The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Victoria, Málaga 29009, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset
authors.forename: Lourdes
authors.initials: L
authors.lastname: Garrido-Sánchez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Tinahones
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D001798:Blood Proteins; D008076:Cholesterol, HDL; D004041:Dietary Fats; D014280:Triglycerides; D014527:Uric Acid