title: Risk factors for chronic renal dysfunction in lung transplant recipients.
abstract: Several factors predispose to renal dysfunction (RD), a common complication of solid organ transplants. We evaluated the impact of clinical and laboratory parameters on the decline of renal function in lung and heart-lung transplant recipients. We enrolled 45 patients who survived more than 6 months after transplantation, had normal renal function and urinalysis before the surgery. The prognostic value of variables for the occurrence of RD was calculated by univariate analysis. Thirty patients developed RD, defined as doubling of serum creatinine or creatinine steadily >1.5 mg/dL after a median time of 12 months. Serum creatinine above 0.9 mg/dL during the month preceding lung transplant, systolic blood pressure above 130 mmHg, and pretransplant idiopathic pulmonary hypertension were significantly associated with the development of RD. Our findings indicate that increased systolic blood pressure, reduced glomerular filtration rate, and idiopathic pulmonary hypertension are risk factors for chronic RD in lung transplant recipients.
authors.affiliation: Unit of Nephrology, Dialysis and Transplantation, University of Pavia, Pavia, Italy. espositociro56@hotmail.com
authors.forename: Ciro
authors.initials: C
authors.lastname: Esposito
authors.forename: Andreana
authors.initials: A
authors.lastname: De Mauri
authors.forename: Patrizio
authors.initials: P
authors.lastname: Vitulo
authors.forename: Tiberio
authors.initials: T
authors.lastname: Oggionni
authors.forename: Flavia
authors.initials: F
authors.lastname: Cornacchia
authors.forename: Rossella
authors.initials: R
authors.lastname: Valentino
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Grosjean
authors.forename: Massimo
authors.initials: M
authors.lastname: Torreggiani
authors.forename: Antonio
authors.initials: A
authors.lastname: Dal Canton
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D015897:Comorbidity; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D007676:Kidney Failure, Chronic / Q000453:epidemiology*; D016040:Lung Transplantation / Q000009:adverse effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D012307:Risk Factors; D014508:Urea / Q000097:blood
chemical_list: D014508:Urea