[Analysis of genetically determined susceptibility to experimental allergic encephalomyelitis in autoimmune diabetes mellitus in rats].
Back cross animals were obtained by mating DA rats, which are highly susceptible to the induction of experimental low-dose streptozotocin induced diabetes, and AO rats, which are resistant to both diseases. Susceptibility to the induction of EAE in AO and DA rats correlates with IL-2 production. after 7 cycles of mating and selection for DA-susceptibility to EAE, the number of EAE susceptible animals decreased, and animals were uniformly resistant to diabetes induction. IL-2 testing revealed lower IL-2 activities in the supernatants of lymphocytes from these animals in comparison to DA rats. Our results reveal the dissociation of genes involved in the regulation of the susceptibility to EAE and autoimmune diabetes. In addition, IL-2 testing, even though argues against the critical role of IL-2, does not preclude the necessity of this lymphokine in the pathogenesis of EAE.
Arsov
I
I
Mostarica-Stojković
M
M
Stosić-Grujicić
S
S
Lukić
M
M
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D051381:Rats; D011919:Rats, Inbred Strains