title: TiF(4) varnish-A (19)F-NMR stability study and enamel reactivity evaluation.
abstract: The aim of this study was to develop a titanium tetrafluoride (TiF(4)) varnish and evaluate the stability of the formulation and its reactivity with dental enamel. The varnish was prepared in a resinous matrix using ethanol 96% as solvent. Samples (n=45) were aged at 65 degrees C and 30% of relativity humidity (RE n degrees 01/05-ANVISA) and after 3, 6, 9 and 12 months, nine samples were removed for evaluation and compared with fresh samples. Chemical stability of TiF(4) varnish was determinate by (19)F-NMR and the reactivity of the formulation was quantified by formation of fluoride loosely (CaF(2)) and firmly bound (fluorapatite; FA) to enamel. For reactivity comparisons, a varnish without TiF(4) was used as control. The loss of soluble fluoride was about 0.9% after one year of storage. The values of the reactivity (mean+/-S.D.) of fresh, aged at 3, 6, 9 and 12 months and control samples were: CaF(2) (microg F/mm(2)): 89.3+/-27.5(a); 54.5+/-14.3(b); 51.2+/-29.8(b); 69.3+/-21.3(a); 48.0+/-27.4(b); 0.10+/-0.07(c), FA (microg F/g): 2477.5+/-1044.0(a); 2484.8+/-992.0(a); 2580.0+/-1383.9(a); 2517.2+/-929.9(a); 2121.0+/-1059.2(a); 330.0+/-180.0(b), respectively. Means followed by distinct letters were statistically different (p<0.05). After one year of storage, the formulation was chemically stable and the levels of FA were maintained. However there was an initial decrease in the ability to form CaF(2).
authors.affiliation: Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Brazil.
authors.forename: Carolina Bezerra Cavalcanti
authors.initials: CB
authors.lastname: Nóbrega
authors.forename: Fred Yukio
authors.initials: FY
authors.lastname: Fujiwara
authors.forename: Jaime Aparecido
authors.initials: JA
authors.lastname: Cury
authors.forename: Pedro Luiz
authors.initials: PL
authors.lastname: Rosalen
mesh_terms: D002124:Calcium Fluoride / Q000032:analysis*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D003743:Dental Enamel / Q000187:drug effects; D005459:Fluorides / Q000138:chemical synthesis* / Q000378:metabolism; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014025:Titanium / Q000378:metabolism
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D014025:Titanium; D002124:Calcium Fluoride; D005459:Fluorides; C032240:titanium tetrafluoride