TINU-associated retinal pigment epithelium detachments: a possible novel posterior segment feature.
OBJECTIVE
To report a case of tubulointerstitial nephritis and uveitis syndrome (TINU) with novel posterior segment features of bilateral vitritis and retinal pigment epithelial detachments.


METHODS
This is an interventional case report with fundus photographs and fluorescein angiograms of a 9-year-old girl presenting with bilateral acute anterior uveitis 4 months after a diagnosis of acute tubulointerstitial nephritis.


RESULTS
Visual acuities remained normal throughout the 6-month period of follow-up. The anterior and posterior uveitis settled, although retinal pigment epithelial detachments persisted and may be related to the underlying disease process in TINU or exogenous steroid treatment, or both.


CONCLUSIONS
The idiopathic inflammatory response seen in TINU is traditionally associated with an anterior uveitis. This case demonstrates that there may be more extensive ocular involvement and that posterior uveitis and retinal pigment epithelial detachments may represent emerging features of atypical cases of TINU.
Sheth
Hiten G
HG
Department of Ophthalmology, North Middlesex University Hospital, Sterling Way, London N18 1QX, UK. drhitensheth@yahoo.co.uk
Laverde-Konig
Tania
T
Raina
Jyoti
J
D000284:Administration, Oral; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002648:Child; D003907:Dexamethasone / Q000008:administration & dosage; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D012163:Retinal Detachment / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013577:Syndrome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D011239:Prednisolone