title: Malignant solitary fibrous tumor of the nasal cavity.
abstract: Solitary fibrous tumors (SFTs) are unusual mesenchymal tumors that were first described as primary spindle-cell neoplasms of the pleura. These tumors have been described in many other locations, including the urogenital system, orbit, mediastinum, and upper respiratory tract. Twenty-two cases of an SFT of the paranasal sinuses and nasal cavity have been reported, but none described a malignant SFT extending through the anterior skull base. A 70-year-old man had a 6-month history of unilateral left-sided epiphora and nasal obstruction. Computed tomography and magnetic resonance imaging showed a large left-sided nasal cavity mass with extension into the left extraconal orbit and intracranial extension through the left cribriform plate and ethmoid roof. The patient underwent preoperative embolization of the internal maxillary artery and a subsequent anterior craniofacial resection via a midfacial degloving approach and a left anterior craniotomy. Histopathological analysis of the specimen was consistent with a malignant SFT.
authors.affiliation: Department of Otolaryngology, New York University School of Medicine, New York, New York.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Zeitler
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Kanowitz
authors.forename: Gady
authors.initials: G
authors.lastname: Har-El