title: Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction.
abstract: The super silyl group governs high diastereoselectivity and yields for a sequential aldol-polyhalomethyllithium addition reaction. This unique silyl group is necessary to obtain the diastereoselectivities associated with this sequential reaction, capable of generating two new stereocenters. Alpha-polyhalomethylcarbinols are generated with the simple and inexpensive dihalomethanes and trihalomethanes.
authors.affiliation: Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Boxer
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto