title: Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations.
abstract: A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantioselective synthesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.
authors.affiliation: Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8066, USA.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Sun
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D004952:Esters / Q000737:chemistry; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D004952:Esters; D008024:Ligands; D010720:Phosphines; D014867:Water; D012428:Ruthenium; C044646:phosphine