Synthesis and cytotoxicity of platinum(II) complexes of a physiologically active carrier histamine.
A series of novel platinum(II) complexes involving a physiologically active carrier histamine as the carrier, cis-[Pt(histamine)X2] (X2=2Cl-, oxalate, malonate, 1,1-cyclobutanedicarboxylate (CBDCA), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative complex cis-[Pt(histamine)Cl2]. The cytotoxicity of the complexes has also been assessed in the human cancer cell lines A549/ATCC, HT-29, and LNcap. One complex, cis-[Pt(histamine)Cl2], is more active than carboplatin against both the sensitive and resistant cells.
Chen
Xi-Zhu
XZ
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, China.
Ye
Qing-Song
QS
Lou
Li-Guang
LG
Xie
Ming-Jin
MJ
Liu
Wei-Ping
WP
Yu
Yao
Y
Hou
Shu-Qian
SQ
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D019008:Drug Resistance, Neoplasm; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002614:Chelating Agents; D009944:Organoplatinum Compounds; C528739:cis-(Pt(histamine)Cl2); D006632:Histamine