LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic.
OBJECTIVE
To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD).


METHODS
Study of 89 Caucasian patients with neovascular (exudative) AMD and 232 Caucasian controls.


METHODS
The Y402H variant of CFH gene and A69S variant of LOC387715/HTRA1 gene locus were examined.


RESULTS
For CFH, the odds ratio for the homozygous variant was 4.97 (CI 2.52 to 9.79). For LOC387715/HTRA1 the odds ratio for the homozygous risk variant was 7.75 (CI 3.46 to 17.35). The odds ratio for heterozygous carriers was 3.35 (CI 1.91 to 5.90).
Pulido
Jose S
JS
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Peterson
Lisa M
LM
Mutapcic
Lejla
L
Bryant
Sandra
S
Highsmith
W Edward
WE
D001483:Base Sequence; D017242:Complement Factor H / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008910:Minnesota; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D017931:DNA Primers; D017242:Complement Factor H