title: Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss.
abstract: Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.
authors.affiliation: Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan. nobu0822@aol.com
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ozawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maruyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagashima
authors.forename: Masanori
authors.initials: M
authors.lastname: Ono
authors.forename: Toru
authors.initials: T
authors.lastname: Arase
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yoshimura
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000235:genetics*; D000328:Adult; D025063:Chromosome Disorders / Q000453:epidemiology* / Q000235:genetics*; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*