Development of highly potent chiral discrimination methods that solve the problems of diastereomer method.
The development of highly potent chiral discrimination methods that solve the problems of the diastereomer method is described. Explaining the significant results of separations of diastereomers having chiral centers separated by 13 - 27 bonds with reversed-phase HPLC was hitherto impossible. To attract more scientific interest toward the mechanism of the separation, the author proposes a hypothesis, Induced Chiral Fields, that the achiral reversed phases can provide chiral fields depending on the structures of the substrates.
Ohrui
Hiroshi
H
Yokohama College of Pharmacy, 601 Matano-cho, Totsuka, Yokohama 245-0066, Japan. h.ohrui@hamayaku.ac.jp
D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013237:Stereoisomerism
D005456:Fluorescent Dyes; D007202:Indicators and Reagents