The interferon signaling network and transcription factor C/EBP-beta.
Cytokines like interferons (IFNs) play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses.
Li
Hui
H
Department of Microbiology & Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, 660 W. Redwood Street, Baltimore, MD 21201, USA.
Gade
Padmaja
P
Xiao
Weihua
W
Kalvakolanu
Dhan V
DV
D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000639:trends; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism; D007372:Interferons / Q000276:immunology / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology* / Q000378:metabolism*; D053612:Janus Kinases / Q000276:immunology; D020935:MAP Kinase Signaling System / Q000276:immunology; D019899:Paracrine Communication / Q000276:immunology; D050791:STAT Transcription Factors / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
D022782:CCAAT-Enhancer-Binding Protein-beta; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D050791:STAT Transcription Factors; D007372:Interferons; D053612:Janus Kinases