title: cadDX operon of Streptococcus salivarius 57.I.
abstract: A CadDX system that confers resistance to Cd(2+) and Zn(2+) was identified in Streptococcus salivarius 57.I. Unlike with other CadDX systems, the expression of the cad promoter was negatively regulated by CadX, and the repression was inducible by Cd(2+) and Zn(2+), similar to what was found for CadCA systems. The lower G+C content of the S. salivarius cadDX genes suggests acquisition by horizontal gene transfer.
authors.affiliation: Department of Microbiology and Immunology, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan. mchen@mail.cgu.edu.tw
authors.forename: Yi-Ywan M
authors.initials: YY
authors.lastname: Chen
authors.forename: C W
authors.initials: CW
authors.lastname: Feng
authors.forename: C F
authors.initials: CF
authors.lastname: Chiu
authors.forename: Robert A
authors.initials: RA
authors.lastname: Burne
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D001482:Base Composition; D001483:Base Sequence; D002104:Cadmium / Q000378:metabolism*; D017931:DNA Primers / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D015723:Gene Library; D008969:Molecular Sequence Data; D009876:Operon / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D017422:Sequence Analysis, DNA; D013291:Streptococcus / Q000235:genetics*; D015032:Zinc / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D017931:DNA Primers; D002104:Cadmium; D015032:Zinc