[Experimental substantiation of hormone replacing therapy by estrogens in treatment and prevention of inflammatory infectious diseases of maxillo-facial region].
Estrogen play the important role in normal current of inflammatory process. At age oppression of synthesis or at surgical menopause in an organism it is formed estrogen-deficiency syndrome shown in particular, in salivary glands change, loss of a jaw bones, disseminated current of inflammatory processes. For study of hormone replacing estrogen's therapy role in experiment, we determine the influence of transdermal estrogen-consisting systems on structure and function of large salivary glands, density of a bone jaws and current of infectious-inflammatory process in laboratory animals. For hormone-replacing estrogen-therapy we used an equivalent doze of estrogen-consisting plaster with a doze of estradiol 0.32 mg per day. The plaster pasted once a week on the ear. Criteria of efficiency were: calculation of bone destruction areas, pathology study of glandulars parotid and densitometries. The received experimental data testify to efficiency of application hormone-replacing estrogen's therapy in inflammatory diseases of maxillofacial area proceeding on a background of estrogen-deficiency.
Iaremenko
A I
AI
Kutukova
S I
SI
D000818:Animals; D004195:Disease Models, Animal; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D020249:Hormone Replacement Therapy / Q000379:methods*; D008439:Maxillary Diseases / Q000473:pathology / Q000517:prevention & control*; D010019:Osteomyelitis / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012793:Sialadenitis / Q000473:pathology / Q000517:prevention & control*; D016896:Treatment Outcome
D004967:Estrogens