title: Comparative associations of adiposity measures with cardiometabolic risk burden in asymptomatic subjects.
abstract: BACKGROUND
  Obesity increases the risk of cardiovascular diseases and diabetes.
  
  
  OBJECTIVE
  To determine which measure of adiposity, body mass index (BMI), waist circumference (WC) or body fat mass (BFM) is the most predictive of the coronary heart disease (CHD) risk and of the presence of the metabolic syndrome.
  
  
  METHODS
  A cross-sectional study of 649 consecutive men and women aged 22-79 years, in primary prevention.
  
  
  RESULTS
  BMI, WC and BFM were strongly associated with conventional cardiometabolic risk factors. For a 1-S.D. increase in BMI, WC and BFM, the odds ratios (95% CIs) of having the metabolic syndrome after adjustment for age, gender, and drug treatments were as follows: BMI, 3.40 (2.68-4.37); WC, 4.79 (3.61-6.53); and BFM, 3.19 (2.49-4.16). WC annihilated the association of BMI and BFM with the metabolic syndrome when measures of adiposity were introduced two by two. For CHD risk, the odds ratios (95% CIs) were as follows: 1.62 (1.16-2.24), 1.72 (1.22-2.42), and 1.92 (1.40-2.62) respectively. BFM annihilated the associations of BMI and WC with CHD risk when measures of adiposity were introduced two by two.
  
  
  CONCLUSIONS
  WC shows the best association with the metabolic syndrome, while BFM shows the best association with high CHD risk. BMI shows weaker relationships with the metabolic syndrome, and high CHD risk. Our findings suggest that BFM can be used as a complementary measure to identify CHD risk in adult subjects.
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Centre de Médecine Préventive Cardiovasculaire, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dervaux
authors.forename: Murine
authors.initials: M
authors.lastname: Wubuli
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Megnien
authors.forename: Gilles
authors.initials: G
authors.lastname: Chironi
authors.forename: Alain
authors.initials: A
authors.lastname: Simon
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D015331:Cohort Studies; D003327:Coronary Disease / Q000175:diagnosis* / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D055105:Waist Circumference