title: Can ABO-incompatible organ transplantation pave the way for clinical xenotransplantation?
abstract: Because of the apparent mechanistic similarities between antibody-mediated rejection of ABO-incompatible organ allografts and vascularized xenografts, there is hope that strategies to enable transplantation across the ABO barrier may also be effective in curbing xenograft rejection. This paper discusses the molecular similarities and differences between an ABO-incompatible allograft and a porcine xenograft in terms of their interactions with the immune system.
authors.affiliation: Division of Clinical Immunology, Karolinska Institute, Karolinska University; Hospital, Huddinge, Stockholm, Sweden. jan.holgersson@ki.se
authors.forename: Jan
authors.initials: J
authors.lastname: Holgersson
mesh_terms: D000017:ABO Blood-Group System; D000818:Animals; D001787:Blood Group Incompatibility; D001803:Blood Transfusion; D002241:Carbohydrates / Q000737:chemistry; D003167:Complement Activation; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D015398:Signal Transduction; D013552:Swine; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous / Q000379:methods*; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D002241:Carbohydrates