T cells in psoriatic arthritis.
Psoriatic arthritis is characterized by chronic inflammation of the skin and synovial joint. T cells are abundant in the inflamed joint and skin. Disease susceptibility is associated with major histocompatibility complex, which presents antigens to T cells. T cells in the synovial joints have an activated phenotype and demonstrate selective T-cell receptor usage suggestive of oligoclonal expansions. Taken together, these facts suggest that psoriatic arthritis is driven by antigen or autoantigen-driven T-cell activation. The therapeutic benefit of anti-T-cell agents further supports an important pathogenic role for T cells in persistent synovial inflammation and joint damage in psoriatic arthritis.
Choy
Ernest
E
Academic Department of Rheumatology, King's College London, Weston Education Center, Cutcombe Road, London, SE5 9PJ, UK. ernest.choy@kcl.ac.uk
D015535:Arthritis, Psoriatic / Q000276:immunology* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D007596:Joints / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology