title: Value of PET/CT versus enhanced CT for locoregional lymph nodes in non-small cell lung cancer.
abstract: OBJECTIVE
  To compare the diagnostic efficacies of integrated (18)F FDG PET/CT images and contrast-enhanced helical CT images in locoregional lymph node metastasis in the patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  From June 2005 to June 2007, 122 potentially operable patients with proven or suspected non-small cell lung cancer underwent integrated PET/CT and contrast-enhanced CT scans followed by surgical nodal staging. The results of reviewing PET/CT and enhanced CT images for the locoregional lymph node metastasis were compared in relation to pathologic findings.
  
  
  RESULTS
  Preoperative nodal staging was compared with postoperative histopathological staging, 80% (98 of 122) of patients correctly staged, 13% (16 of 122) of patients were overstaged, and 7% (8 of 122) were understaged by PET/CT, while those values for CT were 56% (68 of 122), 26% (32 of 122), and 18% (22 of 122), respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT for lymph nodes were 86%, 85%, 85%, 64%, 95%, respectively; compared with 69%, 71%, 70%, 43%, 88% for CT (P=0.000, 0.000, 0.000, 0.001, 0.001, respectively). 81% false-negative interpretations and 72% false-positive interpretations on CT were corrected by PET/CT. 57% false-negative interpretations and 45% false-positive interpretations on PET/CT were corrected by CT. 6 % (9 of 153) positive lymph nodes and 8% (40 of 486) negative nodes at pathology were incorrectly diagnosed both by PET/CT and CT.
  
  
  CONCLUSIONS
  Integrated PET/CT improves the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value than enhanced CT in the assessment of locoregional lymph nodes, and provides more efficient and accurate data of nodal staging, with a better effect on diagnosis and therapy in non-small cell lung cancer.
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China. sdthywf@yahoo.com.cn
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Fu
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
authors.forename: Shuanghu
authors.initials: S
authors.lastname: Yuan
authors.forename: Baijiang
authors.initials: B
authors.lastname: Zhang
authors.forename: Daotang
authors.initials: D
authors.lastname: Li
authors.forename: Ligang
authors.initials: L
authors.lastname: Xing
authors.forename: Dongbo
authors.initials: D
authors.lastname: Zhao
authors.forename: Dianbin
authors.initials: D
authors.lastname: Mu
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Sun
authors.forename: Yufang
authors.initials: Y
authors.lastname: Fang
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Huange
authors.forename: Wanhu
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed