[Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats].
OBJECTIVE
To evaluate the toxicity of Radix Aristolochiae and Radix Inulae, and to supply the toxicity experimental data that Radix Inulae supersedes Radix Aristolochiae in clinic.


METHODS
A long dose of Radix Aristolochice and Radix Inulae was given intragastrically to rats for six months, then drug withdrawal for a month. The hematology and biochemical indicators were measured, and the pathologic changes of kidney, liver, stomach and urinary bladder were examined.


RESULTS
The rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously. Hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered with pathologic assaying. But the rats of Radix Inulae did not.


CONCLUSIONS
Radix Aristolochiae could damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity. Radix Inulae could take the place of Radix Aristolochiae to use in clinic.
Qiao
Hong-Xiang
HX
Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Liu
Yong-Ye
YY
Wu
Li-Mao
LM
Li
Lian-Da
LD
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D030022:Aristolochia / Q000737:chemistry*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D038143:Inula / Q000737:chemistry*; D007684:Kidney Tubules / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009336:Necrosis; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D004365:Drugs, Chinese Herbal; D003404:Creatinine; D000118:Acetylglucosaminidase