title: Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand.
abstract: HIV Associated Dementia (HAD) is a complication of HIV infection in developed countries and is still poorly defined in resource-limited settings. In this study we investigated the expression of the monocyte phenotype CD14CD16HLADR and the inflammatory profiles in monocytes supernatants by surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry in a cohort of HAD and non-HAD Thai volunteers prior to the initiation of ARV. The CD14CD16HLADR phenotype was significantly increased in monocytes from HAD and non-HAD versus negative controls, but there was no difference in phenotype and in the secretion protein profiles between the two seropositive groups. In addition, monocytes supernatants from HAD and non-HAD did not induced apoptosis or cell death in brain aggregate culture. In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts.
authors.affiliation: Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States. silvia.kim@afrims.org
authors.forename: Silvia
authors.initials: S
authors.lastname: Ratto-Kim
authors.forename: Thippawan
authors.initials: T
authors.lastname: Chuenchitra
authors.forename: Lynn
authors.initials: L
authors.lastname: Pulliam
authors.forename: Robert
authors.initials: R
authors.lastname: Paris
authors.forename: Suchitra
authors.initials: S
authors.lastname: Sukwit
authors.forename: Siriphan
authors.initials: S
authors.lastname: Gongwon
authors.forename: Pasiri
authors.initials: P
authors.lastname: Sithinamsuwan
authors.forename: Samart
authors.initials: S
authors.lastname: Nidhinandana
authors.forename: Sataporn
authors.initials: S
authors.lastname: Thitivichianlert
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Shiramizu
authors.forename: Mark S
authors.initials: MS
authors.lastname: de Souza
authors.forename: Suwicha T
authors.initials: ST
authors.lastname: Chitpatima
authors.forename: Bing
authors.initials: B
authors.lastname: Sun
authors.forename: Hans
authors.initials: H
authors.lastname: Rempel
authors.forename: Sorachai
authors.initials: S
authors.lastname: Nitayaphan
authors.forename: Kenneth
authors.initials: K
authors.lastname: Williams
authors.forename: Jerome H
authors.initials: JH
authors.lastname: Kim
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Shikuma
authors.forename: Victor G
authors.initials: VG
authors.lastname: Valcour
mesh_terms: D015526:AIDS Dementia Complex / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000378:metabolism / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D018709:Statistics, Nonparametric; D013785:Thailand / Q000453:epidemiology; D019562:Viral Load
chemical_list: D015704:CD4 Antigens