Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.
The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.
Rodríguez-Nóvoa
Sonia
S
Pharmacokinetic and Pharmacogenetic Unit, Hospital Carlos III, Madrid, Spain.
García-Gascó
Pilar
P
Blanco
Francisco
F
González-Pardo
Gema
G
Castellares
Carol
C
Moreno
Victoria
V
Jiménez-Nácher
Inmaculada
I
González-Lahoz
Juan
J
Soriano
Vincent
V
D019380:Anti-HIV Agents / Q000009:adverse effects*; D015224:Dideoxynucleosides / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005820:Genetic Testing; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011237:Predictive Value of Tests; D013030:Spain; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen