Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities.
BACKGROUND
Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and it may also induce hypopituitarism, conditions associated with an increased risk of cardiovascular diseases.


OBJECTIVE
Cardiovascular and metabolic risk profile investigation in multisystem LCH patients with and without anterior pituitary deficiency.


METHODS
Prospective, observational study.


METHODS
Fourteen adult patients with LCH, 7 with and 7 without anterior pituitary deficiency, and 42 controls matched for age, body mass index (BMI) and smoking. Cardiovascular risk factors were estimated in all subjects: glucose and lipid profile, mathematical indices of insulin resistance (IR), blood pressure, structural arterial and functional endothelial properties (intima-media thickness, brachial artery flow-mediated dilatation). Cardiovascular risk factors were estimated in the three groups studied; the effect of disease activity and/or treatment was also determined in patients with LCH.


RESULTS
Ten patients had diabetes insipidus, and 7 anterior pituitary hormone deficiencies: 8 patients had active disease and 11 had received systemic treatment. No difference was observed between the study groups in vascular parameters, in lipid profile or in blood pressure. However, the insulin resistance index GIR was decreased in patients with LCH without anterior pituitary deficiency compared to controls (P = 0.033). Three patients had impaired glucose tolerance and one diabetes mellitus type 2. These patients were older and had active disease; there was no association with hypopituitarism and/or previous treatment.


CONCLUSIONS
Adults patients with LCH have abnormalities of glucose metabolism that tend to occur in patients with active disease, and may be a consequence of the pro-inflammatory state.
Alexandraki
K I
KI
Department of Endocrinology, Laiko General Hospital, School of Medicine, National & Kapodistrian University of Athens, Themistokleous 19 str, Amaroussion, Athens, Greece. krisalex@med.uoa.gr
Makras
P
P
Protogerou
A D
AD
Dimitriou
K
K
Stathopoulou
A
A
Papadogias
D S
DS
Voidonikola
P
P
Piaditis
G
G
Pittas
A
A
Papamichael
C M
CM
Grossman
A B
AB
Kaltsas
G
G
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D004812:Epidemiologic Methods; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000150:complications*; D005951:Glucose Tolerance Test; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood / Q000150:complications*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000172:deficiency*
D001786:Blood Glucose; D010907:Pituitary Hormones