title: A transformation approach for the analysis of interval-censored failure time data.
abstract: This paper discusses the analysis of interval-censored failure time data, which has recently attracted a great amount of attention (Li and Pu, Lifetime Data Anal 9:57-70, 2003; Sun, The statistical analysis of interval-censored data, 2006; Tian and Cai, Biometrika 93(2):329-342, 2006; Zhang et al., Can J Stat 33:61-70, 2005). Interval-censored data mean that the survival time of interest is observed only to belong to an interval and they occur in many fields including clinical trials, demographical studies, medical follow-up studies, public health studies and tumorgenicity experiments. A major difficulty with the analysis of interval-censored data is that one has to deal with a censoring mechanism that involves two related variables. For the inference, we present a transformation approach that transforms general interval-censored data into current status data, for which one only needs to deal with one censoring variable and the inference is thus much easy. We apply this general idea to regression analysis of interval-censored data using the additive hazards model and numerical studies indicate that the method performs well for practical situations. An illustrative example is provided.
authors.affiliation: Department of Statistics, University of Missouri, Columbia, USA. lzkn7@mizzou.edu
authors.forename: Liang
authors.initials: L
authors.lastname: Zhu
authors.forename: Xingwei
authors.initials: X
authors.lastname: Tong
authors.forename: Jianguo
authors.initials: J
authors.lastname: Sun
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical