A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
Xiang
Dexuan
D
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Wang
Kewei
K
Liang
Yongjiu
Y
Zhou
Guangyuan
G
Dong
Dewen
D
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000577:Amides; D011728:Pyridones