title: Walsucochins A and B with an unprecedented skeleton isolated from Walsura cochinchinensis.
abstract: Walsucochins A (1) and B (2) with an unprecedented skeleton were isolated from Walsura cochinchinensis. Their structures including absolute configuration were elucidated by spectral methods. A biosynthetic pathway of 1 and 2 was postulated. Both 1 and 2 exhibited significant cell protecting activities against H2O2-induced PC12 cell damage.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
authors.forename: Zhi-Wang
authors.initials: ZW
authors.lastname: Zhou
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Fu
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Xi-Can
authors.initials: XC
authors.lastname: Tang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D016716:PC12 Cells; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014315:Triterpenes; C527907:walsucochin A; C527908:walsucochin B; D006861:Hydrogen Peroxide