Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.
In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization (n=12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization (n=6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization.
Johansson
E
E
Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden.
Istrate
C
C
Charpilienne
A
A
Cohen
J
J
Hinkula
J
J
Poncet
D
D
Svensson
L
L
Johansen
K
K
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity; D005260:Female; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000097:blood / Q000276:immunology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D022243:Rotavirus Vaccines