title: Changes in vitamin C and vitamin E during oxidative stress in myocardial reperfusion.
abstract: Injury to the myocardial tissue due to ischemia and reperfusion occurs because of imbalance between the formation of oxidants and available antioxidants in the heart. Levels of vitamin C (ascorbic acid) and vitamin E (alpha--tocopherol) were evaluated in 52 patients of acute myocardial infarction (AMI) treated by streptokinase. They were further divided into reperfused group (39 patients) and non-reperfused group (13 patients). Twenty normal healthy subjects served as controls. Vitamin C and vitamin E were estimated in study group before and after thrombolytic therapy and in controls. Vitamin C levels were low in AMI cases as compared to controls (8.74 +/- 1.87 and 10.63 +/- 3.26 mg/L, respectively, P < 0.001). Trend of fall in vitamin C levels in the two study groups was not statistically significant. Vitamin E levels declined from 12.19 +/- 6.71 to 9.96 +/- 6.50 mg/L by 4 hours which was significant (P < 0.01) in the reperfused group, but the change in non-reperfused group (9.28 +/- 6.37 to 9.35 +/- 6.07 mg/dL by 4 hours) was non-significant. This is because of increased consumption of this antioxidant in suppressing the oxidative stress which occurs with reperfusion. Vitamin E can be proposed as a valid marker for reperfusion.
authors.affiliation: Department of Biochemistry, Dayanand Medical College & Hospital, Ludhiana.
authors.forename: Reema
authors.initials: R
authors.lastname: Sood
authors.forename: A P S
authors.initials: AP
authors.lastname: Narang
authors.forename: Rebecca
authors.initials: R
authors.lastname: Abraham
authors.forename: Uma
authors.initials: U
authors.lastname: Arora
authors.forename: Rajneesh
authors.initials: R
authors.lastname: Calton
authors.forename: Nitin
authors.initials: N
authors.lastname: Sood
mesh_terms: D001205:Ascorbic Acid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000188:drug therapy; D018384:Oxidative Stress; D013300:Streptokinase / Q000627:therapeutic use; D014810:Vitamin E / Q000097:blood*
chemical_list: D015415:Biomarkers; D014810:Vitamin E; D013300:Streptokinase; D001205:Ascorbic Acid