Aplaminal: a novel cytotoxic aminal isolated from the sea hare Aplysia kurodai.
Aplaminal (1), a novel triazabicyclo[3.2.1]octane framework metabolite, has been isolated from the sea hare Aplysia kurodai. The structure was determined by analysis of NMR data and confirmed by single-crystal X-ray diffraction analysis. Aplaminal (1) exhibits cytotoxicity against Hela S3 cells.
Kuroda
Takeshi
T
Department of Chemistry, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, Japan.
Kigoshi
Hideo
H
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001048:Aplysia / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000970:Antineoplastic Agents; D053961:Azabicyclo Compounds; C527920:aplaminal; D005492:Folic Acid