Glutathione and malondialdehyde levels in patients with hydatid cyst.
OBJECTIVE
To investigate the levels of glutathione (GSH), and malondialdehide (MDA) in the sera of patients diagnosed with cyst hydatid.


METHODS
Forty-six hydatid cyst patients who were indirect hemaglutination (IHA) and indirect fluorescence antibody (IFA) test positive constituted our study group in 2007. Patients diagnosed with hydatid cyst in the Inonu University School of Medicine, Department of Parasitology were re-called for the study. Forty healthy subjects who were negative for hydatid cyst by IHA and IFA methods, and who did not have any parasites on stool inspection formed the control group. The MDA level was analyzed in the sera by Uchiyama and Mihara method. The GSH activity was measured by the Ellman method.


RESULTS
The GSH level was 11.31 -/+ 3.80 micromol/L and the MDA level was 67.94 -/+ 106.70 micromol/L in the study group, while they were 24.95 -/+ 6.55 micromol/L and 26.52 -/+ 19.42 micromol/L in the control group.


CONCLUSIONS
An increase in MDA levels and a decrease in GSH activity in patients with hydatid cyst was observed.
Atambay
Metin
M
Department of Parasitology, Inonu University School of Medicine, Ankara, Turkey.
Karaman
Ulku
U
Kiran
Tugba R
TR
Colak
Cemil
C
Karabulut
Aysun B
AB
Celik
Tuncay
T
Daldal
Nilgun
N
D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D004443:Echinococcosis / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018709:Statistics, Nonparametric
D008315:Malondialdehyde; D005978:Glutathione