title: Measurement of the 11C-flumazenil binding in the visual cortex predicts the prognosis of hemianopia.
abstract: In order to determine whether functional neuroimaging studies can predict the prognosis of hemianopia due to organic cerebral disorders, we studied 8 patients (6 men and 2 women; age, 56.0+/-8.6 years) with homonymous hemianopia and compared them with 15 normal subjects (6 men and 9 women; age, 54.3+/-4.4 years). The cerebral glucose metabolism and 11C-flumazenil (FMZ) binding were measured by positron emission tomography, more than 1 month after the onset of the condition. Bilateral regions of interest (ROIs) were selected in the striate cortex, extrastriate cortex, cuneus and thalamus. Further, semi-quantitative data on the cerebral glucose metabolism and FMZ binding were obtained for the ROIs and compared with the data obtained for homologous regions in the contralateral hemisphere by calculating the ipsilateral/contralateral (I/C) ratio. The I/C ratios for the cerebral glucose metabolism and FMZ binding in the striate cortex were significantly low in the patients (glucose metabolism, P<0.0005; FMZ binding, P<0.005), while the ratio for the FMZ binding in the cuneus increased (P<0.0005). We observed that 5 patients, whose I/C ratio for the FMZ binding in the striate cortex was >0.850, experienced an improvement in their visual field, while that 3 patients with lower I/C ratios did not. The FMZ-PET may be useful to predict the prognosis of hemianopia in the chronic phase.
authors.affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Chiharu
authors.initials: C
authors.lastname: Horie
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kiyosawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nariai
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Kiich
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D005260:Female; D005442:Flumazenil; D006423:Hemianopsia / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D014793:Visual Cortex / Q000000981:diagnostic imaging*
chemical_list: D002250:Carbon Radioisotopes; D005442:Flumazenil