title: Acquired factor VIII inhibitor in a patient with dermatomyositis--a case study.
abstract: BACKGROUND
  Acquired factor VIII inhibitor is an antibody formed against FVIII and seen in patients without FVIII replacement therapy. This entity has been associated with both autoimmune disease and infections.
  
  
  METHODS
  We report the case of a 65-year-old man with dermatomyositis who presented with a bleeding episode following venipuncture and hematuria. His coagulation parameters were followed as well as the inhibitor level. His acquired FVIII inhibitor was managed successfully with rituximab.
  
  
  CONCLUSIONS
  Our patient's bleeding episodes resolved and the inhibitor level was undetectable after 12 months. This is the first case of acquired FVIII inhibitor in association with dermatomyositis.
authors.affiliation: Department of Medicine, Franklin Square Hospital Center, Baltimore, MD 21237, USA. ayodeleayoola@hotmail.com
authors.forename: Ayodele
authors.initials: A
authors.lastname: Ayoola
authors.forename: Wajahath
authors.initials: W
authors.lastname: Mohsini
authors.forename: Sein
authors.initials: S
authors.lastname: Aung
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies / Q000097:blood*; D003882:Dermatomyositis / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000276:immunology*; D006801:Humans; D008297:Male; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D000069283:Rituximab; D005169:Factor VIII