[In vitro evaluation of self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong].
OBJECTIVE
To investigate the evaluation method for self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong (VOC SEDDS).


METHODS
The self-emulsifying ability, the efficiency of self-emulsification, the properties of emulsion, the dissolution of volatile oil from Rhizome of Ligusticum Chuanxiong and the stability of the emulsion were determined.


RESULTS
The optimized formulation can fully emulsify in 5 min and the particle sizes were around 102 nm. Zeta potential was about -30 mV. The O/W emulsions were stable through centrifugation with high reproducibility. In vitro dissolution test indicated that over 80% of drug dissolved in 30 min and VOC SEDDS was stable under light and high temperature in 10 d.


CONCLUSIONS
VOC SEDDS has strong self-emulsifying ability, fine stability and high dissolution rate in vitro.
Cai
Qin
Q
Postdoctor Mobile Station, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. liursh2006@163.com
Liang
Long
L
Huang
Yan-Ping
YP
Hou
Shi-Xiang
SX
D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D008027:Light; D030004:Ligusticum / Q000737:chemistry*; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
D004655:Emulsions; D009822:Oils, Volatile; D013501:Surface-Active Agents