[The significance and current diagnostic options of cytogenetic changes in multiple myeloma].
Multiple myeloma is a malignant disease caused by malign transformation of B-cells, their clonal proliferation and the accumulation of myeloma cells in the bone marrow. These cells are set apart by a pronounced genetic instability. Chromosomal abnormalities are probably the most important prognostic factors in myeloma which influence the division of the patients into individual sub-groups each with a different developmental process of the disease and thus a different approach during treatment. The study summarizes the methodological approaches and current options in classical and molecular cytogenetics during the examination of cytogenetic changes in multiple myeloma. It presents the most common types of numerical and structural chromosomal changes found in the karyotype of multiple myeloma patients, and their prognostic importance.
Kuglík
P
P
Katedra genetiky a molekulární biologie Ustavu experimentální biologie Prírodovedecké fakulty MU, Brno. kugl@sci.muni.cz
Filková
H
H
Oltová
A
A
Hájek
R
R
D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*