title: Malignant transformation of multiple familial trichoepithelioma: case report and literature review.
abstract: Patients with the autosomal-dominant form of multiple familial trichoepithelioma develop numerous tumours on the face, neck and upper trunk, beginning in childhood. Malignant transformation of such lesions is quite rare; only one case of "malignant trichoepithelioma" has been reported previously, inferring pilomatrix carcinoma on a histological observation. We report here the case of a patient who developed a malignant neoplasm in a long-standing trichoepithelioma lesion on her buttock. Histopathology revealed a transformation zone between the trichoepithelioma and a malignant tumour mass. This case also showed several features of a malignant neoplasm of trichoblastic origin.
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, 2 Sosa-Dong, Wonmi-Gu, Pucheon-Si, Kyunggi-Do, Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Baik Kee
authors.initials: BK
authors.lastname: Cho
authors.forename: Yu Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Chul Jong
authors.initials: CJ
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018280:Carcinoma, Skin Appendage / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*