Clinical and angiographic results after implantation of a passive-coated coronary stent in patients with acute myocardial infarction.
BACKGROUND
Key insights into the role of platelets in acute myocardial infarction (AMI) and unstable angina have led to the development of the polymer-coated stent, Camouflage(R). Coating of stents is an elegant method to minimize interactions between platelets and the stent surface and the vascular response following stent implantation.


METHODS
This single-center prospective registry was performed to estimate the in-hospital, 30-day and 180-day event rate (death, revascularization, reinfarction and pathological stress test at 180 days) in an everyday patient population with AMI with immediate percutaneous coronary intervention. There were 44 males (65.7%) and 23 females (34.3%); 53 patients (79.1%) had hypertension, 11 (16.4%) were diabetic, and 32 (47.8%) had elevated LDL cholesterol. The mean age was 60.7 +/- 11.6 years.


RESULTS
Sixty-seven patients with AMI (STEMI: 56.7%, NSTEMI: 43.3%) were included. Clinical data at the 30-day and 180-day follow up were available for all but 1 of the patients. Overall, there were 3 (4.5%) deaths, 1 (1.5%) death at 30 days and 2 (3.0%) at 180 days (1 cardiogenic shock 3, 1 sudden cardiac death and 1 AMI). Three (4.5%) patients experienced subacute closure of the target vessel. At 180 days, 1 (1.5%) patient had a pathological stress test and 5 patients (7.5%) underwent target vessel revascularization.


CONCLUSIONS
The registry with this passive-coated stent showed good results in patients with AMI, consistent with earlier studies. Data are now available both for the development of hypotheses and for a data-based estimation of the number of cases for a comparative clinical study versus other coronary stents.
Ozbek
Cem
C
Volklingen Heart Center, Chief, Internal Medicine Clinic I, Richardstrasse 5-9 , Volklingen, 66333, Germany. oezbek@ihkf.de
Bay
Wolfgang
W
Jochum
Lorenz
L
Jung
Friedrich
F
Bach
Roland
R
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D011108:Polymers / Q000494:pharmacology; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015607:Stents; D016019:Survival Analysis; D016896:Treatment Outcome; D014654:Vascular Patency
D020099:Coated Materials, Biocompatible; D011108:Polymers