title: The effect of opioid administration by different routes on the psychological functions of elderly patients.
abstract: Psychological status of patients during epidural and intravenous (i.v.) morphine administration are not known enough. It's known that after administration of morphine epidurally and intravenously plasma concentrations are similar but the concentrations in cerebrospinal fluide are different. The effects of two postoperative analgesia treatment regimens on the psychological and mental functions of the elderly after major orthopedic surgery were investigated in this randomized, blinded study. Morphine was used epidurally in Group E and intravenously in Group IV with patient controlled analgesia method for postoperative analgesia treatment. All patients were assessed for psychological status the day before surgery and 2 days after surgery using the Brief Symptom Inventory (BSI). The results of the BSI were assessed with the Global Severity Index (GSI). Nine subscales were also derived: depression, somatization, obsessive-compulsive, anxiety, interpersonal sensitivity, hostility, phobic anxiety, paranoid ideation, and psychoticism. There was not significant difference between the groups for preoperative and postoperative GSI results (p>0.05). Only interpersonal sensitivity subscale results in Group i.v. were decreased compared to the baseline (p<0.001). Preoperative BSI and submeasurement test scores revealed no correlation with total morphine consumption in both groups (p>0.05). Mental changes like agitation, time and place disorientation were seen equally in both groups. This study showed that after epidural and intravenouse morphine administration, no psychologycal changes were observed in the postoperative period compared with baseline. Patients who received morphine intravenously were showed less interpersonal sensitivity in the postoperative period.
authors.affiliation: Ministry of Health Ankara Research and Training Hospital, Department of Anesthesiology, Ankara, Turkey. nurteninan@yahoo.com
authors.forename: Nurten
authors.initials: N
authors.lastname: Inan
authors.forename: Türkay
authors.initials: T
authors.lastname: Cakan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozen
authors.forename: Nihan
authors.initials: N
authors.lastname: Aydin
authors.forename: Dilek
authors.initials: D
authors.lastname: Gürel
authors.forename: Bülent
authors.initials: B
authors.lastname: Baltaci
mesh_terms: D000368:Aged; D015360:Analgesia, Epidural; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006299:Health Services for the Aged; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D019637:Orthopedic Procedures; D010149:Postoperative Pain / Q000517:prevention & control*; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine