title: Invasive fungal rhinosinusitis in Maharaj Nakorn Chiang Mai Hospital.
abstract: BACKGROUND
  Invasive fungal rhinosinusitis, a rare infection, is a life threatening disease. Delay in diagnosis may consequently lead to high morbidity and mortality.
  
  
  OBJECTIVE
  Encourage early detection and proper management of invasive fungal rhinosinusitis.
  
  
  METHODS
  Medical records, radiological, and pathological reports of five patients who were diagnosed as invasive fungal rhinosinusitis were reviewed retrospectively.
  
  
  RESULTS
  Four in five cases of invasive fungal rhinosinusitis, confirmed by pathological study, had successful treatment. One patient had intracerebral hemorrhage that may be associated with the disease spreading. Disease extension was evaluated by CT paranasal sinus in all cases, but it usually did not have classic bony erosion.
  
  
  CONCLUSIONS
  Curing infection, correcting underlying conditions, and working up fungal infection should be carried out as early as possible, because morbidity and mortality depend on disease extension and host status.
authors.affiliation: Otolaryngology Department, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Kannika
authors.initials: K
authors.lastname: Roongrotwattanasiri
authors.forename: Supranee
authors.initials: S
authors.lastname: Fooanant
authors.forename: Luxana
authors.initials: L
authors.lastname: Naksane
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D012189:Retrospective Studies; D012220:Rhinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D012852:Sinusitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013785:Thailand; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B