Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli.
A collection of structurally closely related furanones was synthesized to identify the most important structural elements in brominated furanones for inhibiting the formation of bacterial biofilms. The results suggest that a conjugated exocyclic vinyl bromide on the furanone ring is the most important structural element for the non-toxic but inhibition activity for Escherichia coli biofilm formation. Furanones bearing monosubstituted bromide groups on saturated carbons were found to have a toxic effect that attenuates the bacterial growth.
Han
Yongbin
Y
Department of Chemistry, Syracuse University, NY 13244, USA.
Hou
Shuyu
S
Simon
Karen A
KA
Ren
Dacheng
D
Luk
Yan-Yeung
YY
D000818:Animals; D001422:Bacterial Adhesion; D018441:Biofilms; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D053038:Quorum Sensing / Q000187:drug effects; D013329:Structure-Activity Relationship
D005663:Furans; D006842:Hydrocarbons, Brominated