title: Blood stem cell mobilization and collection in patients with lymphoproliferative diseases: practical issues.
abstract: More than 15,000 autologous stem cell transplants (ASCT) were reported to European Blood and Bone Marrow Transplantation registry in 2005, most commonly for multiple myeloma (MM) and lymphomas. In 98% of the cases high-dose therapy was supported by blood stem cells. Thus stem cell mobilization and collection are integral parts of ASCT protocols. We give here a practical approach to blood stem cell mobilization and collection in patients with various lymphoproliferative diseases. While mobilization is usually easy and straightforward in patients with MM, about 10-20% of patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma are hard-to-mobilize. There seems to be even more disease-specific issues in blood stem cell mobilization in patients with chronic lymphocytic leukaemia and in patients with light chain amyloidosis. We also discuss options in hard-to-mobilize patients.
authors.affiliation: Department of Medicine, Kuopio University Hospital, Kuopio, Finland. esa.jantunen@kuh.fi
authors.forename: Esa
authors.initials: E
authors.lastname: Jantunen
authors.forename: Taru
authors.initials: T
authors.lastname: Kuittinen
mesh_terms: D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000628:therapy*; D010361:Patients; D012680:Sensitivity and Specificity