Calcification of Hydroview H60M intraocular lenses: aqueous humor analysis and comparisons with other intraocular lens materials.
OBJECTIVE
To compare the level of calcification on Hydroview H60M hydrophilic acrylic intraocular lenses (IOLs) (Bausch & Lomb) and other IOL materials.


METHODS
Omori Medical Center, Department of Ophthalmology, Toho University, Tokyo, Japan.


METHODS
The levels of calcification on Hydroview H60M hydrophilic acrylic IOLs, AcrySof SA60AT hydrophobic acrylic IOLs (Alcon Surgical, Inc.), Sensar AR40e hydrophobic acrylic IOLs (Advanced Medical Optics), ClariFlex (Advanced Medical Optics) silicone IOLs, and the MeniFlex ENV13 (Menicon) poly(methyl methacrylate) IOLs were compared in a calcium phosphate solution containing albumin. In a concentration-change experiment, the calcium and phosphate concentration levels were changed and the results observed by scanning electron microscopy.


RESULTS
The Hydroview H60M IOL had the largest amount of deposits. Small amounts of deposits were found on the other IOLs in the following decreasing order: AcrySof SA60AT, Sensar AR40e, ClariFlex, and MeniFlex ENV13. The amount of deposits on the Hydroview H60M IOLs was statistically significantly greater than the amount on the other IOLs (P<.01).


CONCLUSIONS
The hydrophilic acrylic IOLs (Hydroview H60M) had significantly higher amounts of calcified deposits than IOLs of other materials, indicating that hydrophilic acrylic IOLs easily accumulate calcified deposits in the body when the concentrations of calcium, phosphate, and albumin in the aqueous humor fluctuate as a result of a blood-aqueous barrier breakdown.
Nakanome
Saiko
S
Omori Medical Center, Department of Ophthalmology, Toho University, Tokyo, Japan. saisai0117@yahoo.co.jp
Watanabe
Hiroshi
H
Tanaka
Koichiro
K
Tochikubo
Tetsuo
T
D000180:Acrylic Resins; D000418:Albumins / Q000378:metabolism; D001082:Aqueous Humor / Q000378:metabolism*; D018916:Blood-Aqueous Barrier; D002114:Calcinosis / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002199:Capillary Permeability; D003930:Diabetic Retinopathy / Q000150:complications; D004577:Electron Probe Microanalysis; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D018918:Phacoemulsification; D010758:Phosphorus / Q000378:metabolism*; D019904:Polymethyl Methacrylate; D011475:Prosthesis Failure; D012086:Reoperation; D012826:Silicone Elastomers
D000180:Acrylic Resins; D000418:Albumins; D012826:Silicone Elastomers; D010758:Phosphorus; D019904:Polymethyl Methacrylate; D002118:Calcium