title: [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin].
abstract: OBJECTIVE
  To study the effect of O/W Microemulsion in enhancing solubility of baicalin and puerarin.
  
  
  METHODS
  The Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of baicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively.
  
  
  RESULTS
  11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 - 4 times than it in water.
  
  
  CONCLUSIONS
  Microemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China. yanghua2796@sina.com
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.forename: Man-Ling
authors.initials: ML
authors.lastname: Li
authors.forename: Zan-Ye
authors.initials: ZY
authors.lastname: Cao
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Feng
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions; D005419:Flavonoids / Q000032:analysis* / Q000737:chemistry; D007529:Isoflavones / Q000032:analysis* / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D004655:Emulsions; D005419:Flavonoids; D007529:Isoflavones; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; C038044:baicalin; C033607:puerarin