title: White thrombus formation in blood tubing lines in a chronic hemodialysis unit.
abstract: OBJECTIVE
  Previous reports have described white particulate matter in banked blood components, but no prior public reports describe such matter in blood tubing during the course of routine in-center hemodialysis. This report describes the events, investigations, and preliminary conclusions associated with the spontaneous formation of adherent white thrombus in the venous and arterial blood lines during routine in-center hemodialysis treatments. Design setting, participants, & measurements: This investigation occurred at the Portland Veterans Administration Medical Center (PVAMC) Hemodialysis Unit from October 2006 through April 2007. Sixty-eight variables regarding demographics, medical history and dialysis treatments were collected on our 34 chronic hemodialysis outpatients.
  
  
  RESULTS
  Over a 5-wk interval, 62% (21 of 34) of the chronic hemodialysis patients unexpectedly developed a white precipitate adhering to the lumenal surface of their dialysis blood tubing, with 73 of 580 chronic dialysis treatments exhibiting the phenomenon. Microscopic and biochemical analyses were consistent with white thrombus, formed by an aggregation of platelets and fibrin. An alert was issued and other in-center hemodialysis units noted similar findings. This was remedied by the removal of specific tubing.
  
  
  CONCLUSIONS
  Both patient-specific and tubing-specific factors may have been operative. Although patient safety was not adversely affected, assessment of clinical and manufacturing variables potentially affecting platelet activation is warranted.
authors.affiliation: P3 NEPH, Medical Director, Dialysis Unit, PVAMC, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA. watnicks@ohsu.edu
authors.forename: Suzanne
authors.initials: S
authors.lastname: Watnick
authors.forename: Michael
authors.initials: M
authors.lastname: Stooksbury
authors.forename: Rolf
authors.initials: R
authors.lastname: Winter
authors.forename: Michael
authors.initials: M
authors.lastname: Riscoe
authors.forename: David M
authors.initials: DM
authors.lastname: Cohen
mesh_terms: D000368:Aged; D002404:Catheterization / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation*; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology