TiF(4) varnish-A (19)F-NMR stability study and enamel reactivity evaluation.
The aim of this study was to develop a titanium tetrafluoride (TiF(4)) varnish and evaluate the stability of the formulation and its reactivity with dental enamel. The varnish was prepared in a resinous matrix using ethanol 96% as solvent. Samples (n=45) were aged at 65 degrees C and 30% of relativity humidity (RE n degrees 01/05-ANVISA) and after 3, 6, 9 and 12 months, nine samples were removed for evaluation and compared with fresh samples. Chemical stability of TiF(4) varnish was determinate by (19)F-NMR and the reactivity of the formulation was quantified by formation of fluoride loosely (CaF(2)) and firmly bound (fluorapatite; FA) to enamel. For reactivity comparisons, a varnish without TiF(4) was used as control. The loss of soluble fluoride was about 0.9% after one year of storage. The values of the reactivity (mean+/-S.D.) of fresh, aged at 3, 6, 9 and 12 months and control samples were: CaF(2) (microg F/mm(2)): 89.3+/-27.5(a); 54.5+/-14.3(b); 51.2+/-29.8(b); 69.3+/-21.3(a); 48.0+/-27.4(b); 0.10+/-0.07(c), FA (microg F/g): 2477.5+/-1044.0(a); 2484.8+/-992.0(a); 2580.0+/-1383.9(a); 2517.2+/-929.9(a); 2121.0+/-1059.2(a); 330.0+/-180.0(b), respectively. Means followed by distinct letters were statistically different (p<0.05). After one year of storage, the formulation was chemically stable and the levels of FA were maintained. However there was an initial decrease in the ability to form CaF(2).
Nóbrega
Carolina Bezerra Cavalcanti
CB
Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Brazil.
Fujiwara
Fred Yukio
FY
Cury
Jaime Aparecido
JA
Rosalen
Pedro Luiz
PL
D002124:Calcium Fluoride / Q000032:analysis*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D003743:Dental Enamel / Q000187:drug effects; D005459:Fluorides / Q000138:chemical synthesis* / Q000378:metabolism; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014025:Titanium / Q000378:metabolism
D002327:Cariostatic Agents; D005460:Fluorides, Topical; D014025:Titanium; D002124:Calcium Fluoride; D005459:Fluorides; C032240:titanium tetrafluoride