title: Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.
abstract: T-type calcium channel antagonists were designed using a protocol involving the program SPROUT and constrained by a ComFA-based pharmacophore model. Scaffolds generated by SPROUT were evaluated based on their ability to be translated into structures that were synthetically tractable. From this exercise, a novel series of potent and selective T-type channel antagonists containing a biaryl sulfonamide core were discovered.
authors.affiliation: Bristol-Myers Squibb R& D, Princeton, NJ 08543-5400, USA. jon.hangeland@bms.com
authors.forename: Jon J
authors.initials: JJ
authors.lastname: Hangeland
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Cheney
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Friends
authors.forename: Stephen
authors.initials: S
authors.lastname: Swartz
authors.forename: Paul C
authors.initials: PC
authors.lastname: Levesque
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Rich
authors.forename: Lucy
authors.initials: L
authors.lastname: Sun
authors.forename: Terry R
authors.initials: TR
authors.lastname: Bridal
authors.forename: Leonard P
authors.initials: LP
authors.lastname: Adam
authors.forename: Diane E
authors.initials: DE
authors.lastname: Normandin
authors.forename: Natesan
authors.initials: N
authors.lastname: Murugesan
authors.forename: William R
authors.initials: WR
authors.lastname: Ewing
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology*; D020747:Calcium Channels, T-Type / Q000187:drug effects*; D018360:Crystallography, X-Ray; D015195:Drug Design; D066298:In Vitro Techniques; D018408:Patch-Clamp Techniques; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D013449:Sulfonamides