The reduction in electric footshocks perception interferes with the amnesic effect of scopolamine.
In a passive avoidance paradigm, administration of scopolamine in mice seems to provoke forgetting of electric shocks they received when entering into the black compartment. We observed that, in fact, scopolamine reduced the shocks perception. Since, on the hot plate test, scopolamine did not affect latencies of avoidance reactions, this effect did not correspond to analgesia. Thus, in our experimental conditions, scopolamine effect did not exclusively result from a deficit of passive avoidance learning but likely resulted from its anti-sweating properties, thus reducing the shocks perception.
Torquet
N
N
Unité de Neuropsychopharmacologie, FRE 2735 CNRS-IFRMP, Faculté de Médecine et Pharmacie, 22, boulevard Gambetta, 76183 Rouen Cedex, France.
Hagues
G
G
Costentin
J
J
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology*; D014828:Vocalization, Animal / Q000187:drug effects / Q000502:physiology
D018377:Neurotransmitter Agents; D012601:Scopolamine