Immune reconstitution in children after unrelated cord blood transplantation.
There is a great need to learn more about the biology of immune recovery after UCBT. Fundamental gaps in knowledge remain regarding the biology and kinetics of developing antigen-specific protective immunity and understanding the impact of recipient age and immunosuppressive agents. However, there is also realistic hope that clinical translation of new immunotherapy strategies could enhance immune competence after UCBT either by having an impact on the thymic-independent early period or by fostering thymic recovery.
Szabolcs
Paul
P
Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Department of Immunology, Duke University, Durham, North Carolina, USA. szabo001@mc.duke.edu
Niedzwiecki
Donna
D
D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology / Q000502:physiology; D006410:Hematopoiesis / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000502:physiology*; D012038:Regeneration