Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane.
OBJECTIVE
The aim of the present case series was to evaluate the 2-year results obtained following treatment of peri-implantitis lesions using either a nanocrystalline hydroxyapatite (NHA) or a natural bone mineral in combination with a collagen membrane (NBM+CM).


METHODS
Twenty-two patients suffering from moderate peri-implantitis (n=22 intra-bony defects) were randomly treated with (i) access flap surgery (AFS) and the application of NHA, or with AFS and the application of NBM+CM. Clinical parameters were recorded at baseline and after 12, 18, and 24 months of non-submerged healing.


RESULTS
Two patients from the NHA group were excluded from the study due to severe pus formation at 12 months. At 24 months, both groups revealed clinically important probing depth (PD) reductions (NHA: 1.5+/-0.6 mm; NBM+CM: 2.4+/-0.8 mm) and clinical attachment level (CAL) gains (NHA: 1.0+/-0.4 mm; NBM+CM: 2.0+/-0.8 mm). However, these clinical improvements seemed to be better in the NBM+CM group (difference between groups: PD reduction: 0.9+/-0.2 mm; CAL gain: 1.0+/-0.3 mm).


CONCLUSIONS
Both treatment procedures have shown efficacy over a period of 24 months, however, the application of NBM+CM may result in an improved outcome of healing.
Schwarz
Frank
F
Department of Oral Surgery, Westdeutsche Kieferklinik, Heinrich Heine University, Düsseldorf, Germany. Frank.Schwarz@med.uni-duesseldorf.de
Sculean
Anton
A
Bieling
Katrin
K
Ferrari
Daniel
D
Rothamel
Daniel
D
Becker
Jürgen
J
D018786:Bone Substitutes / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D017886:Durapatite / Q000627:therapeutic use*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D053758:Nanoparticles / Q000627:therapeutic use; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D011859:Radiography; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome
C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D017886:Durapatite