title: What does 'best medical therapy' really mean?
abstract: Carotid disease is like any other atherosclerotic manifestation, a condition, which may induce thrombosis, in this case with subsequent cerebral ischemia. Carotid endarterectomy has proven effective in preventing ipsilateral stroke, however, the studies providing the evidence were conducted before the use of statins, newer antiplatelet and antihypertensive drugs, and at a time when less emphasis was on lifestyle modification. Therefore, it is likely that, not only would all patients with carotid stenosis benefit from modern medical treatment, in addition, some patients could have similar risk reduction to that of endarterectomy, were these effective preventive drugs used systematically, as recommended, in this patient group. This article reviews the evidence that is available concerning medical therapy for patients with carotid stenosis, with special emphasis on antiplatelet and statin therapy. An example on how this treatment may be organised is given.
authors.affiliation: Department of Vascular Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark. henrik.sillesen@rh.dk
authors.forename: H
authors.initials: H
authors.lastname: Sillesen
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001291:Attitude of Health Personnel; D016893:Carotid Stenosis / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D002983:Clinical Competence; D004359:Drug Therapy, Combination; D016894:Endarterectomy, Carotid; D007722:Health Knowledge, Attitudes, Practice; D006297:Health Services Accessibility; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D018579:Patient Selection; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D055502:Secondary Prevention; D012720:Severity of Illness Index; D009626:Terminology as Topic; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D010975:Platelet Aggregation Inhibitors