title: Clostridium difficile infection precipitating hemolysis in glucose-6-phosphate dehydrogenase-deficient preterm twins causing severe neonatal jaundice.
abstract: The incidence of glucose-6-phosphate dehydrogenase deficiency in neonates of immigrant mothers in Canada is increasing. Newborn screening programs in Canada do not screen for this disorder. Infants with G-6-PD deficiency may develop jaundice resulting in kernicterus with devastating sequelae. In this case report, we speculate that Clostridium difficile infection may have triggered severe jaundice in G-6-PD-deficient neonates.
authors.affiliation: Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. abhay.lodha@calgaryhealthregion.ca
authors.forename: A
authors.initials: A
authors.lastname: Lodha
authors.forename: M S
authors.initials: MS
authors.lastname: Kamaluddeen
authors.forename: E
authors.initials: E
authors.lastname: Kelly
authors.forename: H
authors.initials: H
authors.lastname: Amin
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000235:genetics / Q000382:microbiology* / Q000503:physiopathology; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000150:complications*; D004751:Enteritis / Q000150:complications* / Q000382:microbiology; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011247:Pregnancy; D014427:Twins