Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea.
We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.
Kim
Dong Soo
DS
Department of Pediatrics, Yonsei University College of Medicine, Severance Chilfren's Hospital, Seoul, South Korea. dskim6634@yumc.yonsei.ac.kr
Lee
Taek Jin
TJ
Kang
Jin Han
JH
Kim
Jong-Hyun
JH
Lee
Jung Hyun
JH
Ma
Sang Hyuk
SH
Kim
Sun Young
SY
Kim
Hwang Min
HM
Shin
Son Mun
SM
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007723:Korea; D016865:Reassortant Viruses / Q000276:immunology*; D012401:Rotavirus / Q000276:immunology; D022243:Rotavirus Vaccines / Q000009:adverse effects* / Q000276:immunology*
D000914:Antibodies, Viral; D022243:Rotavirus Vaccines; C058442:WC3 rotavirus vaccine