title: Coincidental association of mycosis fungoides and occupational systemic sclerosis?
abstract: We report a 58-year-old man with mycosis fungoides (MF) and occupational systemic sclerosis (SSc) induced by silica exposure. He was engaged in tunnel construction from the age of 18 to 33 years. He developed MF at the age of 30. Diagnosis of silicosis was made at the age of 52 and SSc at the age of 58. Physical examinations revealed sclerotic skin changes on his forearms and fingers and poikiloderma on the left popliteal fossa and inguinal region. Both antinuclear antibody and antitopoisomerase-I antibody were positive. We could find no apparent difference between his clinical features and those of idiopathic SSc except for the presence of silicosis and MF. Systemic therapy with interferon-gamma for MF did not improve the skin sclerosis. We discuss the relationship of silica exposure to both MF and SSc.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan. myasuda@showa.gunma-u.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Yasuda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Amano
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamanaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009784:Occupational Diseases / Q000150:complications* / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000209:etiology; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D012822:Silicon Dioxide