title: No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal.
abstract: To analyze possible effects of microwaves on gene expression, mice were exposed to global system for mobile communication (GSM) 1800 MHz signal for 1 h at a whole body SAR of 1.1 W/kg. Gene expression was studied in the whole brain, where the average SAR was 0.2 W/kg, by expression microarrays containing over 22,600 probe sets. Comparison of data from sham and exposed animals showed no significant difference in gene expression modulation. However, when less stringent constraints were adopted to analyze microarray results, 75 genes were found to be modulated following exposure. Forty-two probes showed fold changes ranging from 1.5 to 2.8, whereas 33 were down-regulated from 0.67- to 0.29-fold changes, but these differences in gene expression were not confirmed by real-time PCR. Under these specific limited conditions, no consistent indication of gene expression modulation in whole mouse brain was found associated to GSM 1800 MHz exposure.
authors.affiliation: Department of Health Sciences, Public Health Unit, University Institute of Movement Sciences (IUSM), Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Paparini
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Gianfranceschi
authors.forename: V
authors.initials: V
authors.lastname: Brugaletta
authors.forename: R
authors.initials: R
authors.lastname: Falsaperla
authors.forename: P
authors.initials: P
authors.lastname: De Luca
authors.forename: V
authors.initials: V
authors.lastname: Romano Spica
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects*; D040421:Cell Phone; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008872:Microwaves; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011829:Radiation Dosage; D014157:Transcription Factors / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology* / Q000528:radiation effects*
chemical_list: D009419:Nerve Tissue Proteins; D014157:Transcription Factors