Study of qingre liyan decoction in treating and preventing acute radioactive oral mucositis.
OBJECTIVE
To study the effect of Qingre Liyan Decoction (QRLYD) in the prevention and treatment of acute radiative oral mucositis (AROM), and to explore the mechanism of QRLYD by detecting epidermal growth factor (EGF) and T lymphocytes (CD3, CD4, and CD8).


METHODS
Sixty patients conforming with the standard were randomly assigned to two groups, 30 patients in each group. Patients in the trial group were treated with QRLYD, and those in the control group were treated with Dobell's solution, both groups receiving conventional radiation treatment. The treatment course for both groups was 6 weeks on average. Blood routine test, CD3, CD4, and CD8 in the peripheral blood and EGF in the saliva were detected one day before and on the 14th and 28th day of radio-therapy.


RESULTS
Patients in the trial group were in good condition with normal spirits and intake of food and drinks. The incidence of AROM is lower and the effect in preventing AROM is higher in the trial group than those in the control group (P<0.05). The EGF in saliva, and CD4 and CD8 in the blood of patients in the trial group were higher than those in the control group (P<0.05).


CONCLUSIONS
QRLYD can cure and prevent AROM. The mechanism may be related with its effects in enhancing body immunity and promoting salivary EGF.
Wu
Min-hui
MH
Department of Integrative Medicine, Shaanxi Province Oncology Hospital, Xi'an, 710061, China.
Yuan
Bin
B
Liu
Qiu-fang
QF
Wang
Qian
Q
D000208:Acute Disease; D000328:Adult; D002277:Carcinoma / Q000532:radiotherapy; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000009:adverse effects; D010976:Platelet Count; D011832:Radiation Injuries / Q000188:drug therapy* / Q000517:prevention & control*; D013280:Stomatitis / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D004815:Epidermal Growth Factor