Peritoneal membrane evaluation in routine clinical practice.
OBJECTIVE
Establishment of reference values for small solute transport, sodium sieving and effluent CA125 with 3.86% (4 h) peritoneal equilibration test (PET), and comparison with fast-fast PET with regard to small solute transport categories.


METHODS
Cross-sectional study; 69 prevalent patients. Sodium sieving corrected for sodium diffusion with a formula applicable to the PET. CA125 appearance rate (AR) was measured. Expected and observed 60 min D/P(creatinine) were compared by Bland and Altman.


RESULTS
Means (95% CI): D/P(creatinine) 0.73 (0.70-0.76), MTAC(creatinine) 9.6 (8.4-10.9) ml/min, D/D0 glucose 0.30 (0.28-0.31), corrected dip 0.17 (0.15-0.18), CA125 150 (125-176) U/min. Both corrected and uncorrected sodium sieving were informative. Peritoneal transport was faster at 60 min dwell. UFF patients presented very low corrected dip and CA125 AR.


CONCLUSIONS
3.86% (4 h) PET provided results similar to those from SPA. Correction for diffusion of sodium sieving is dispensable for simple clinical evaluations. D/P(creatinine) at 60 min overestimated small solute transport rate. Effluent CA125 was consistently lower in UFF patients.
Rodrigues
Anabela S
AS
Department of Nephrology, Hospital General Santo Antonio, University of Porto, Porto, Portugal. ar.cbs@mail.telepac.pt
Silva
Sandra
S
Bravo
Fernanda
F
Oliveira
Jose C
JC
Fonseca
Isabel
I
Cabrita
Antonio
A
Krediet
Raymond T
RT
D001692:Biological Transport; D002118:Calcium / Q000032:analysis; D003401:Creatine / Q000032:analysis; D003430:Cross-Sectional Studies; D004058:Diffusion; D006801:Humans; D008567:Membranes, Artificial; D010530:Peritoneal Dialysis / Q000295:instrumentation / Q000592:standards*; D010537:Peritoneum / Q000378:metabolism; D011868:Radioisotopes; D012016:Reference Values; D012964:Sodium / Q000032:analysis; D014462:Ultrafiltration
D008567:Membranes, Artificial; D011868:Radioisotopes; D012964:Sodium; D003401:Creatine; D002118:Calcium