title: Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia.
abstract: The epidemiology of genital herpes is changing with evidence to suggest an increasing incidence of herpes simplex virus type 1 (HSV-1) infections. The results of 6529 HSV genital cultures taken between April 1998 and December 2001 were reviewed. overall, HSV-1 was recovered more often than HSV-2; 1213 versus 1045. This trend was particularly striking in young women 30 years of age or less, in whom 70.8% of isolates were HSV-1. In men of the same age range, 45% of isolates were HSV-1. The proportion of women with HSV-1 declined from 73.7% in those younger than 31 years of age to 4.5% in those older than 60 years of age.These observations have important implications. The decline in the relative proportion of HSV-1 isolates from young adults may be the result of changing sexual practices, changing susceptibility or increased exposure to HSV-1 during vaginal intercourse. In this setting HSV-2 vaccines may be less likely to produce the desired reduction in the overall prevalence of genital herpes infections.
authors.affiliation: Departments of Pathology, Medicine, and Microbiology and Immunology, Dalhousie University and the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Forward
authors.forename: Spencer Hs
authors.initials: SH
authors.lastname: Lee