title: An educational video to increase clinical trials enrollment among lung cancer patients.
abstract: BACKGROUND
  Only 3 to 5% of new adult cancer patients participate in clinical trials nationwide. The lack of knowledge and awareness about clinical trials is a significant barrier to clinical trials participation. A randomized trial was conducted to test the effect of an educational video on positively changing patients' knowledge and attitudes regarding clinical trials and thereby increasing enrollment rates.
  
  
  METHODS
  Lung cancer patients were randomized to viewing either an 18-minute video about clinical trials before first clinic appointment or to standard care. Participants completed a baseline and 2-week postintervention survey to assess their knowledge and attitudes toward trials participation. Fisher's exact test tests, t tests, and regression were used to compare patient characteristics and outcomes between arms.
  
  
  RESULTS
  Of 145 subjects randomized, 126 (63/arm) satisfied all inclusion criteria and were included in the analysis. A linear regression showed that the video intervention was significantly associated with patients' self-assessed likelihood to enroll score measured at 2-week follow-up (p = 0.019). Although statistically insignificant, enrollment rates were found to be higher in the intervention arm for therapeutic trials alone (17.5% versus 11.1%) and for therapeutic and nontherapeutic trials combined (25.4% versus 15.9%).
  
  
  CONCLUSIONS
  The brief educational video seems to be effective in positively changing lung cancer patients' attitudes about participation in clinical trials. Higher enrollment rates were also observed in the intervention group but the differences did not reach statistical significance. These findings suggest a potential impact of the educational video on clinical trial enrollment; however, larger studies are needed to confirm these findings.
authors.affiliation: Carman and Ann Adams Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, 3901 Beaubien, Room 3N47, Detroit, MI 48201, USA. duw@med.wayne.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Darlene
authors.initials: D
authors.lastname: Mood
authors.forename: Shirish
authors.initials: S
authors.lastname: Gadgeel
authors.forename: Michael S
authors.initials: MS
authors.lastname: Simon
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000628:therapy*; D018961:Educational Technology; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016014:Linear Models; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D011795:Surveys and Questionnaires; D014743:Videotape Recording; D044465:White People / Q000706:statistics & numerical data