Anti-inflammatory effect of sulodexide during acute peritonitis in rats.
OBJECTIVE
Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically.


METHODS
Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (i.m.) injection.


RESULTS
In rats given i.m. sulodexide the dialysate cell count was lower by 45% (p < 0.001) versus untreated rats with peritonitis. Dialysate elastase activity in i.m. sulodexide-treated rats was lower by 22% (p < 0.05) compared to peritonitis. In rats treated with i.m. sulodexide the increase of plasma tumor necrosis factor-alpha was reduced by 53% (p < 0.002). Pretreatment with i.m. sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p < 0.002) and by 16% (p < 0.05), respectively.


CONCLUSIONS
Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.
Karoń
Jacek
J
Department of Pathophysiology, Poznań Medical School, Poznań, Poland.
Połubinska
Alicja
A
Antoniewicz
Artur A
AA
Sumińska-Jasińska
Katarzyna
K
Breborowicz
Andrzej
A
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; C007858:glucuronyl glucosamine glycan sulfate