Review article: endoscopic antireflux procedures - an unfulfilled promise?
BACKGROUND
Most published reviews concerning the endoscopic treatment of gastro-oesophageal reflux disease date back to 2005.


OBJECTIVE
To provide an updated review that includes all papers published up to 2007.


METHODS
A Medline search from January 2005 to June 2007 was performed regarding endoscopic procedures aiming at treating gastro-oesophageal reflux disease. In addition, we retrieved the abstracts presented at Digestive Disease Week during the last 3 years. We included in the review both 'mechanistic' studies - that is, papers exploring the potential mechanism of action of the procedure/device - and studies trying to assess its clinical efficacy.


RESULTS
During the last 3 years, the number of published papers has declined, and some devices are not available any more. The alleged mechanism(s) of action of the various devices or procedures is (are) still not completely elucidated; however, some concerns have arisen as far as durability and potential detrimental effects. Moreover, all the aspects of endoscopic therapy, except for its safety, are either insufficiently explored or not investigated at all, or assessed only in particularly selected patient subgroups.


CONCLUSIONS
None of the proposed antireflux therapies has fulfilled the criteria of efficacy, safety, cost, durability and, possibly, of reversibility. There is at present no definite indication for endoscopic therapy of gastro-oesophageal reflux disease. We suggest a list of recommendations to be followed when a new endoscopic therapeutic procedure is to be assessed for use in clinical practice.
Pace
F
F
U.O. e Cattedra di Gastroenterologia, Ospedale Universitario L. Sacco, Milan, Italy. fabio.pace@unimi.it
Costamagna
G
G
Penagini
R
R
Repici
A
A
Annese
V
V
D004724:Endoscopy / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000628:therapy*; D006801:Humans