title: A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.
abstract: Insulin resistance (IR) is postulated to underlie diabetes, the metabolic syndrome (MS) and cardiovascular disease (CVD). The D20S32e marker close to the melanocortin receptor-3 (hMC3-R) has been shown to be associated with IR in a large New Zealand Māori kindred, a population at high risk for MS and CVD. Here we examine the potential association of the D20S32e marker with the MS in this 60 member Māori kindred. There was a significant association between the D20S32e "B" allele and the fasting insulin component under both polygenic (beta=-5.3077; p=0.008) and common sibship effect (beta=-4.2161; p=0.03) models. No significant association between the same allele of D20S32e and the MS was observed after adjusting for age under a polygenic (p=0.103) or sibling (p=0.09) correlation model. We conclude that in this Māori kindred, the D20S32e polymorphism is significantly associated with insulin resistance but not with MS. Our data supports the hypothesis that multiple gene variants are necessary for the development of the MS.
authors.affiliation: Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia; Discipline of Medicine, University of Sydney, Sydney, Australia.
authors.forename: Jencia
authors.initials: J
authors.lastname: Wong
authors.forename: Nora L
authors.initials: NL
authors.lastname: Nock
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Xu
authors.forename: Cam
authors.initials: C
authors.lastname: Kyle
authors.forename: Andre
authors.initials: A
authors.lastname: Daniels
authors.forename: Marie
authors.initials: M
authors.lastname: White
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Yue
authors.forename: Robert C
authors.initials: RC
authors.lastname: Elston
authors.forename: Kathleen G
authors.initials: KG
authors.lastname: Mountjoy
mesh_terms: D001315:Australia; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D024821:Metabolic Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D044104:Receptor, Melanocortin, Type 3 / Q000235:genetics*
chemical_list: D044104:Receptor, Melanocortin, Type 3