Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas.
OBJECTIVE
Vulvar squamous cell carcinoma (VSCC) is a disease of significant clinical importance, which arises in the presence or absence of human papillomavirus (HPV).


METHODS
We used comparative genomic hybridization (CGH) to document non-random chromosomal gains and losses with HPV positive and negative VSCCs.


RESULTS
Gains of 3q and 12q were significantly more common in HPV-positive cancers compared to HPV-negative cancers where chromosome 8q was more commonly gained in HPV-negative compared to HPV-positive cancer chromosomes and, 4p and 3p were lost in both categories of VSCCs.


CONCLUSIONS
The data indicate that one or more oncogenes important in the development and progression of HPV-induced carcinomas are located on 3q and 12q.
Yangling
O
O
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Shulang
Z
Z
Rongli
C
C
Bo
L
L
Lili
C
C
Xin
W
W
D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000821:virology*; D017931:DNA Primers; D005260:Female; D042822:Genomic Instability; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification*; D014846:Vulvar Neoplasms / Q000235:genetics* / Q000821:virology*
D017931:DNA Primers