title: Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
abstract: Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Wakim
authors.forename: Jason
authors.initials: J
authors.lastname: Waithman
authors.forename: Nico
authors.initials: N
authors.lastname: van Rooijen
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
authors.forename: Francis R
authors.initials: FR
authors.lastname: Carbone
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology* / Q000637:transplantation / Q000821:virology; D006561:Herpes Simplex / Q000276:immunology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000502:physiology; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology; D014775:Virus Activation
chemical_list: D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus