Non-invasive near infrared fluorescence imaging of CdHgTe quantum dots in mouse model.
Near infrared CdHgTe quantum dots (QDs) acted as biomarker for in vivo imaging were synthesized in aqueous solution. The size and the fluorescence wavelength of the synthesized quantum dots can be arbitrary manipulated by using different refluxing time. In particular, the fluorescence wavelength was extended to near infrared range (700 approximately 900 nm), which make the in vivo imaging possible. Meanwhile, the characteristics, such as morphology, size, spectra, stability and toxicity were investigated. The dynamic bio-distribution, clearance from blood, liver and intestine in living animal were in vivo monitored by a NIR imaging system. The circulation of CdHgTe QDs in living mice was addressed semi-quantitatively according to the changes of fluorescence intensity. The high stability as well as high fluorescence intensity makes QDs particular interested candidates for in vivo imaging studies.
Chen
Haiyan
H
Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Shennong Road, Nanjing, 210009, People's Republic of China.
Wang
Yunqing
Y
Xu
Jing
J
Ji
Jinzi
J
Zhang
Jian
J
Hu
Yuzhu
Y
Gu
Yueqing
Y
D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted / Q000379:methods; D017669:Mercury Compounds / Q000737:chemistry*; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D053758:Nanoparticles / Q000648:ultrastructure; D010316:Particle Size; D045663:Quantum Dots; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013691:Tellurium / Q000737:chemistry*; D051598:Whole Body Imaging / Q000379:methods
D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D017669:Mercury Compounds; D013691:Tellurium