title: The influence of age on intestinal dipeptidyl peptidase IV (DPP IV/CD26), disaccharidases, and alkaline phosphatase enzyme activity in C57BL/6 mice.
abstract: The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p < .05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.
authors.affiliation: Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors.forename: Dijana
authors.initials: D
authors.lastname: Detel
authors.forename: Lara
authors.initials: L
authors.lastname: Baticic
authors.forename: Jadranka
authors.initials: J
authors.lastname: Varljen
mesh_terms: D000375:Aging / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D004186:Disaccharidases / Q000378:metabolism*; D004386:Duodenum / Q000201:enzymology; D007082:Ileum / Q000201:enzymology; D007413:Intestinal Mucosa / Q000201:enzymology*; D007583:Jejunum / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D008871:Microvilli / Q000201:enzymology
chemical_list: D000469:Alkaline Phosphatase; D004186:Disaccharidases; D018819:Dipeptidyl Peptidase 4