Thrombophilia in young patients with acute myocardial infarction.
OBJECTIVE
To investigate the association of thrombophilia and coronary artery disease (CAD) in patients with myocardial infarction (MI).


METHODS
Under the age of 45 years, 129 patients with MI and 107 control subjects were included into the study. Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated.


RESULTS
There were statistically significant differences in terms of obesity, smoking, triglyceride, total cholesterol, high-density lipoprotein, high-density lipoprotein, and very-low-density lipoprotein cholesterol, family history, hypertension, diabetes, and left ventricular hypertrophy between patients and controls. None of the patients and controls had protein C, protein S, and antithrombin III deficiencies. Ten patients (7.8%) and 4 controls (3.7%) had heterozygote FV Leiden mutation. Homozygous prothrombine G20210A gene mutation was detected in one patient (1.1%). Homozygous MTHFR C677T mutation was observed in 7.8% (patients) and in 6.5% (controls). Heterozygous MTHFR C677T mutation was detected 36.4% in patients and 31.7% in controls. The difference was not statistically significant in terms of carriage of thrombophilic mutations.


CONCLUSIONS
We found that traditional risk factors increased the risk of CAD. Prothrombin G20210A, FV Leiden and MTHFR C677T mutations, protein C, S and AT-III deficiencies did not increase the risk of CAD in our young population.
Celik
Murat
M
Internal Medicine, Clinical of Internal Diseases, Nusaybin State Hospital, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Altintas
Abdullah
A
Celik
Yusuf
Y
Karabulut
Aziz
A
Ayyildiz
Orhan
O
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis; D005165:Factor V / Q000378:metabolism; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000378:metabolism; D009154:Mutation; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood* / Q000235:genetics
D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; D004247:DNA; D042965:Methylenetetrahydrofolate Reductase (NADPH2)