title: ERP amplitude and latency in breast cancer survivors treated with adjuvant chemotherapy.
abstract: OBJECTIVE
  Neurocognitive problems that were observed in a number of breast cancer survivors treated with adjuvant chemotherapy initiated a series of EEG studies to examine the neurophysiological basis of these deficits. The aim of the present study was to examine the effects of various regimens of adjuvant chemotherapy on the N1 and P3 component of the event-related potential (ERP) in breast cancer patients 3-6 years after treatment.
  
  
  METHODS
  Fifty-three breast cancer patients treated with various chemotherapy regimens were compared to 23 stage I breast cancer patients not treated with chemotherapy. An auditory oddball task was used to study the amplitude, latency and structure of the potential field of the N1 and P3.
  
  
  RESULTS
  Patients treated with chemotherapy showed lower P3 amplitudes than patients not treated with chemotherapy. Differences were also observed in P3 latency between patients treated with different chemotherapy regimens.
  
  
  CONCLUSIONS
  Our results indicate a general effect of all chemotherapy regimens under study on P3 amplitude and a more specific chemotherapeutic effect on P3 latency.
  
  
  CONCLUSIONS
  The present study provides evidence for the notion that different chemotherapy regimens have different effects on brain functioning.
authors.affiliation: Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Baudewijntje P C
authors.initials: BPC
authors.lastname: Kreukels
authors.affiliation: Department of Clinical Neurophysiology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Neurology, Slotervaart Hospital, Amsterdam, The Netherlands.
authors.forename: Hans L
authors.initials: HL
authors.lastname: Hamburger
authors.affiliation: Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Michiel B
authors.initials: MB
authors.lastname: de Ruiter
authors.affiliation: Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; Department of Psychology, University of Amsterdam, The Netherlands.
authors.forename: Frits S A M
authors.initials: FSAM
authors.lastname: van Dam
authors.affiliation: Department of Psychology, University of Amsterdam, The Netherlands; Department of Psychology, Leiden University, The Netherlands.
authors.forename: K Richard
authors.initials: KR
authors.lastname: Ridderinkhof
authors.affiliation: Department of Neurology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Boogerd
authors.affiliation: Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: s.schagen@nki.nl.
authors.forename: Sanne B
authors.initials: SB
authors.lastname: Schagen
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D018592:Cross-Over Studies; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects*; D017741:Survivors