title: Proteolytic activity of Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane.
abstract: Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of 1,4,7,10-tetraazacyclododecane by using albumin, gamma-globulin, and myoglobin as substrates. Values of kcat/Km were greater for Cu(II)oxacyclen by 40-80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom with oxygen.
authors.affiliation: Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Jang
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
mesh_terms: D003300:Copper / Q000737:chemistry*; D006868:Hydrolysis; D045726:Metalloproteases / Q000138:chemical synthesis* / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D003300:Copper; D045726:Metalloproteases