title: Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study.
abstract: OBJECTIVE
  The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components.
  
  
  METHODS
  A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome.
  
  
  RESULTS
  At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40-0.95]) and in the prevalence of abdominal obesity (0.48 [0.28-0.81]).
  
  
  CONCLUSIONS
  The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.
authors.affiliation: Diabetes Center, Finnish Diabetes Association, Tampere, Finland. pirjo.ilanneparikka@diabetes.fi
authors.forename: Pirjo
authors.initials: P
authors.lastname: Ilanne-Parikka
authors.forename: Johan G
authors.initials: JG
authors.lastname: Eriksson
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.forename: Sirkka
authors.initials: S
authors.lastname: Aunola
authors.forename: Helena
authors.initials: H
authors.lastname: Hämäläinen
authors.forename: Sirkka
authors.initials: S
authors.lastname: Keinänen-Kiukaanniemi
authors.forename: Mauri
authors.initials: M
authors.lastname: Laakso
authors.forename: Timo T
authors.initials: TT
authors.lastname: Valle
authors.forename: Jorma
authors.initials: J
authors.lastname: Lahtela
authors.forename: Matti
authors.initials: M
authors.lastname: Uusitupa
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000517:prevention & control*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000534:rehabilitation*; D008875:Middle Aged; D015995:Prevalence; D013997:Time Factors
chemical_list: D001786:Blood Glucose