title: Evaluation of left ventricular function three years after percutaneous recanalization of chronic total coronary occlusions.
abstract: We investigated early and late effects of percutaneous revascularization for chronic total coronary occlusion on left ventricular (LV) function and volumes. Magnetic resonance imaging was performed in 21 patients before and 5 months and 3 years after recanalization. Global LV function and volumes and segmental wall thickening (SWT) were quantified on cine images. The 2 viability indexes used were the transmural extent of infarction (TEI) on delayed contrast enhancement images and end-diastolic wall thickness at baseline. Significant decreases in mean end-diastolic (86 +/- 14 to 78 +/- 15 ml/m2; p = 0.02) and mean end-systolic volume indexes (35 +/- 13 to 30 +/- 13 ml/m2; p = 0.03) were observed 3 years after recanalization. Mean ejection fraction tended to improve (60 +/- 9% to 63 +/- 11%; p = 0.11). SWT significantly increased at 5-months' follow-up (p <0.001), and an additional improvement was found at 3 years' (p = 0.04) follow-up in segments with TEI <25%. In segments with TEI of 25% to 75%, SWT was unchanged at 5-month follow-up (p = 0.89), but improved at 3 years (p = 0.04). SWT was unchanged in segments with transmural scars. For segmental functional recovery, TEI was a better predictor than end-diastolic wall thickness at baseline (odds ratio 5.6, 95% confidence interval 1.5 to 21.1, p = 0.01 vs odds ratio 2.5, 95% confidence interval 0.7 to 8.3, p = 0.14). In conclusion, a positive effect on LV remodeling and ejection fraction was observed up to 3 years after recanalization. Both early and late improvements in regional LV function were observed in the perfusion territory of chronic total coronary occlusion and were related to the transmural extent of infarction on pretreatment magnetic resonance imaging.
authors.affiliation: Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Sharon W
authors.initials: SW
authors.lastname: Kirschbaum
authors.forename: Timo
authors.initials: T
authors.lastname: Baks
authors.forename: Martin
authors.initials: M
authors.lastname: van den Ent
authors.forename: George
authors.initials: G
authors.lastname: Sianos
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: Krestin
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Pim J
authors.initials: PJ
authors.lastname: de Feyter
authors.forename: Robert-Jan M
authors.initials: RJ
authors.lastname: van Geuns
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002908:Chronic Disease; D023921:Coronary Stenosis / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*