title: Drug susceptibility profiling of tuberculous meningitis.
abstract: Drug-resistant tuberculosis is an increasing problem worldwide. There are few reports of drug susceptibility patterns of Mycobacterium tuberculosis isolated from cases of tuberculous meningitis. A 5-year retrospective study aimed at analysing the drug susceptibility profile of M. tuberculosis isolated from tuberculous meningitis cases was conducted. A total of 366 isolates were analysed. Among these, 301 (82.2%) were sensitive to all the four primary drugs tested, while 65 (17.8%) showed resistance. There were 46 (12.5%) isolates resistant to isoniazid (INH), while 9 (2.4%) demonstrated multidrug resistance. These data suggest that multidrug resistance in tuberculous meningitis is not yet a serious problem. However, a periodic review is required to ascertain the global incidence of drug-resistant tuberculous meningitis.
authors.affiliation: Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. nagarathnachandrashekar@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Nagarathna
authors.forename: W
authors.initials: W
authors.lastname: Rafi
authors.forename: H B
authors.initials: HB
authors.lastname: Veenakumari
authors.forename: R
authors.initials: R
authors.lastname: Mani
authors.forename: P
authors.initials: P
authors.lastname: Satishchandra
authors.forename: A
authors.initials: A
authors.lastname: Chandramuki
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000494:pharmacology; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D012189:Retrospective Studies; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin