Raloxifene effects on thyroid gland morphology in ovariectomized rats.
We aimed to analyze the effects of raloxifene and estrogen on thyroid gland morphology of ovariectomized rats. Raloxifene treatment led to effects similar to those of estrogen on thyroid glands from ovariectomized rats, so that both were able to normalize the changes detected after ovariectomy.
de Araujo
Luiz Felipe Bittencourt
LF
Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. lfbita@gmail.com
Grozovsky
Renata
R
de Campos Pinheiro
Mônica
M
de Carvalho
Jorge José
JJ
Vaisman
Mário
M
Carvalho
Denise P
DP
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000187:drug effects*
D004967:Estrogens; D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride