title: Consistency of initial antiretroviral therapy with HIV treatment guidelines in a US cohort of HIV-infected women.
abstract: BACKGROUND
  HIV treatment guidelines define optimal initial antiretroviral therapy (ART).
  
  
  OBJECTIVE
  To characterize initial ART used by a cohort of HIV-infected women according to US HIV treatment guidelines and determine whether regimen characteristics predict short-term outcomes.
  
  
  METHODS
  Initial ART self-reported by Women's Interagency HIV Study (WIHS) participants. Regimens were classified as guideline consistent (GC), guideline not recommended (GNR), or unlisted. Univariate and multivariate logistic regression was used to analyze factors associated with guideline category.
  
  
  RESULTS
  Two hundred seventeen WIHS participants initiated ART during the study period. Fifty-three percent reported use ofGC ART, 17% reported GNR ART, and 30% reported ART unlisted in guidelines. Study site, higher pretreatment CD4 cell count, lower HIV RNA level, and initiation before 2001 were associated with use of GNR regimens. GC ART users had a higher rise in CD4 cell counts and more frequent undetectable HIV-1 RNA levels 2 years after initiation compared with those GNR (P = 0.0003) or unlisted initial ART.
  
  
  CONCLUSIONS
  A higher than expected proportion of WIHS participants reported using initial ART not recommended by HIV treatment guidelines, although this decreased over time. Use of such regimens was associated with a higher incidence of switching and poorer short-term immunologic and virologic outcomes.
authors.affiliation: Department of Clinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA 94143, USA. cocohobaj@pharmacy.ucsf.edu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cocohoba
authors.forename: Qiong J
authors.initials: QJ
authors.lastname: Wang
authors.forename: Christopher
authors.initials: C
authors.lastname: Cox
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gange
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.forename: Marshall
authors.initials: M
authors.lastname: Glesby
authors.forename: Jack A
authors.initials: JA
authors.lastname: DeHovitz
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Greenblatt
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active / Q000592:standards*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006679:HIV Seropositivity / Q000097:blood; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D017410:Practice Guidelines as Topic / Q000592:standards*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D019562:Viral Load