Primary signet-ring cell carcinoma of the prostate.
We report a rare case of primary signet-ring cell carcinoma of the prostate in an advanced stage. A 62-year-old man with serum level of prostate-specific antigen at 364.70 ng/ml was diagnosed as having cT4N1M1c prostatic signet-ring cell carcinoma of Gleason score 5 + 4 = 9. Immunohistochemical examination demonstrated cytoplasmic immunoreactivity to prostate-specific antigen in signet-ring cancer cells. The intracytoplasmic vacuoles in the signet-ring cells showed mucin production with a positive staining with periodic acid-Schiff. Although the patient received hormonal therapy, the disease progressed and lead to death 15 months after the diagnosis. The clinical and immunohistochemical characteristics of this malignancy are also reviewed.
Matsuoka
Yoh
Y
Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan.
Arai
Gaku
G
Ishimaru
Hisashi
H
Takagi
Kentaro
K
Ito
Yuji
Y
D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy