title: Assessment of cadaveric livers discarded from transplantation. A correlation between clinical and histological parameters.
abstract: BACKGROUND
  We designed a study with the following aims: to assess tissue quality of 100 cadaveric livers discarded from transplantation, to identify discarded organs which could have been used either for transplantation or for isolation of hepatocytes, to assess donor clinical factors which may impact the histology.
  
  
  METHODS
  Liver wedge biopsies were performed during kidney procurement, sent for processing and data interpretation.
  
  
  RESULTS
  In 46% of the evaluated tissues severe changes were found; these organs according to pathologists were "not suitable for transplantation". In 19% less pronounced changes classified organs as "probably not suitable for transplantation". In 35% biopsies only minimal changes were found; these organs were classified as "probably suitable for transplantation" and could have been harvested as marginal organs or at least used for hepatocytes isolation.
  
  
  CONCLUSIONS
  Results of biopsies suggested that approximately in one third of livers discarded from transplantation due to clinical donor parameters could have been harvested from histological point of view. Several donor clinical risk factors (alcohol addiction, hyperbilirubinemia, increased transaminase activity) correlate with severe histological changes rending the liver "not suitable for transplantation".
authors.affiliation: Department of Surgical and Transplant Nursing, Medical University of Warsaw, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Czerwiński
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Perkowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mróz
authors.forename: Beata
authors.initials: B
authors.lastname: Lagiewska
authors.forename: Leszek
authors.initials: L
authors.lastname: Adadyński
authors.forename: Magdalena
authors.initials: M
authors.lastname: Durlik
authors.forename: Maciej
authors.initials: M
authors.lastname: Głyda
authors.forename: Wojciech
authors.initials: W
authors.lastname: Lisik
authors.forename: Marek
authors.initials: M
authors.lastname: Pacholczyk
authors.forename: Leszek
authors.initials: L
authors.lastname: Paczek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Polak
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Sledzinski
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wasiak
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Włodarczyk
authors.forename: Janusz
authors.initials: J
authors.lastname: Wałaszewski
authors.forename: Piotr
authors.initials: P
authors.lastname: Małkowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Chmura
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rowiński
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002102:Cadaver; D002469:Cell Separation; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation; D008875:Middle Aged; D012307:Risk Factors; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000592:standards*; D019737:Transplants / Q000592:standards*