title: Renal Fanconi syndrome and myopathy after liver transplantation: drug-related mitochondrial cytopathy?
abstract: Advances in the field of transplantation provide a better quality of life and allow more favorable conditions for growth and development in children. However, combinations of different therapeutic regimens require consideration of potential adverse reactions. We describe a 15-yr-old girl who had orthotopic liver transplantation because of Wilson's disease. Tacrolimus, MMF, and steroids were given as immunosuppressant. Lamivudine was added because of de nova hepatitis B infection during her follow-up. Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspected to be the cause of late post-transplant renal acidosis and was replaced by sirolimus, acidosis, and electrolyte imbalance got worse. Proximal muscle weakness has developed during her follow-up. Fanconi syndrome, as well as myopathy, is well recognized in patients with mitochondrial disorders and caused by depletion of mtDNA. We suggest that our patient's tubular dysfunction and myopathy may have resulted from mitochondrial dysfunction which is triggered by tacrolimus and augmented by lamivudine.
authors.affiliation: Department of Pediatric Nephrology, Baskent University, Ankara, Turkey. ukavak@yahoo.com
authors.forename: Umut Selda
authors.initials: US
authors.lastname: Bayrakci
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Figen
authors.initials: F
authors.lastname: Ozcay
authors.forename: Binnaz Handan
authors.initials: BH
authors.lastname: Ozdemir
authors.forename: Hamdi
authors.initials: H
authors.lastname: Karakayali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D002648:Child; D004359:Drug Therapy, Combination; D005198:Fanconi Syndrome / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D019259:Lamivudine / Q000009:adverse effects*; D016031:Liver Transplantation; D008930:Mitochondria, Liver / Q000187:drug effects*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D016559:Tacrolimus