title: Evidence of a posterior cingulate involvement (Brodmann area 31) in dyslexia: a study based on source localization algorithm of event-related potentials.
abstract: The study investigates the differences regarding the position of intracranial generators of P50 component of ERPs in 38 dyslexic children aged 11.47+/-2.12 years compared with their 19 healthy siblings aged 12.21+/-2.25. The dipoles were extracted by solving the inverse electromagnetic problem according to the recursively applied and projected multiple signal classification (RAP-MUSIC) algorithm approach. For improved localization of the main dipole the solutions were optimized using genetic algorithms. The statistical analysis revealed differences regarding the position of intracranial generators of low frequency of P50. Particularly, dyslexics showed main activity being located at posterior cingulate cortex (Brodmann's area 31) while controls exhibited main activity being located at retrosplenial cortex (Brodmann's area 30). These results may indicate a role for the posterior cingulate cortex in the pre-attentive processing operation of dyslexia beyond of its traditional function in terms of spatial attention and motor intention.
authors.affiliation: Biomedical Simulations and Imaging Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens, Greece. stoitsis@biosim.ntua.gr
authors.forename: John
authors.initials: J
authors.lastname: Stoitsis
authors.forename: Giorgos A
authors.initials: GA
authors.lastname: Giannakakis
authors.forename: Charalabos
authors.initials: C
authors.lastname: Papageorgiou
authors.forename: Konstantina S
authors.initials: KS
authors.lastname: Nikita
authors.forename: Andreas
authors.initials: A
authors.lastname: Rabavilas
authors.forename: Dimitris
authors.initials: D
authors.lastname: Anagnostopoulos
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000465:Algorithms; D001931:Brain Mapping; D002648:Child; D004307:Dose-Response Relationship, Radiation; D004410:Dyslexia / Q000473:pathology* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011597:Psychomotor Performance; D011930:Reaction Time; D012815:Signal Processing, Computer-Assisted