title: Activated protein C resistance and factor V Leiden in Mexico.
abstract: A common cause of hereditary thrombophilia is activated protein C resistance (APCR), and most cases result from factor V Leiden mutation. An APCR phenotype without association with factor V Leiden has been described. This transversal, observational, nonrandomized study evaluated these 2 phenomena in healthy indigenous and mestizo Mexican subjects (n = 4345), including 600 Mexican natives. No indigenous subjects had APCR, but 82 mestizo subjects did. After retesting, 50 subjects had a negative test. The remaining 32 subjects had factor V Leiden, giving a 0.85% prevalence of factor V Leiden in the mestizo Mexican population. Only 31% of APCR carriers had factor V Leiden. These results show a very low prevalence of APCR and factor V Leiden in Mexico. Except for factor V Leiden, there are no other mutations in the factor V gene responsible for the APCR phenotype. Acquired APCR is nearly twice as prevalent as the inherited variant.
authors.affiliation: Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico. amajlufc@prodigy.netmx
authors.forename: Abraham
authors.initials: A
authors.lastname: Majluf-Cruz
authors.forename: Manuel
authors.initials: M
authors.lastname: Moreno-Hernández
authors.forename: Adriana
authors.initials: A
authors.lastname: Ruiz-de-Chávez-Ochoa
authors.forename: Rosario
authors.initials: R
authors.lastname: Monroy-García
authors.forename: Karim
authors.initials: K
authors.lastname: Majluf-Cruz
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Guardado-Mendoza
authors.forename: Irma
authors.initials: I
authors.lastname: Molina-Avila
authors.forename: Irma
authors.initials: I
authors.lastname: Isordia-Salas
authors.forename: Norma
authors.initials: N
authors.lastname: Corona-de la Peña
authors.forename: Florencia
authors.initials: F
authors.lastname: Vargas-Vorackova
authors.forename: Jorge
authors.initials: J
authors.lastname: Vela-Ojeda
authors.forename: Jaime
authors.initials: J
authors.lastname: García-Chávez
mesh_terms: D020016:Activated Protein C Resistance / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence
chemical_list: C095381:factor V Leiden; D005165:Factor V