Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation.
This work aims at investigating different types and levels of hydrophilic matrixing agents, including methylcellulose (MC), sodium alginate (Alg), and sodium carboxymethylcellulose (CMC), in an attempt to formulate controlled-release matrix tablets containing 25 mg baclofen. The tablets were prepared by wet granulation. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. In vitro, newly formulated controlled-release tablets were compared with standard commercial tablets (Lioresal and baclofen). The excipients used in this study did not alter physicochemical properties of the drug, as tested by the thermal analysis using differential scanning calorimetry. The flow and compression characteristics of the prepared granules significantly improved by virtue of granulation process. Also, the prepared matrix tablets showed good mechanical properties (hardness and friability). MC- and Alg-based tablet formulations showed high release-retarding efficiency, and good reproducibility and stability of the drug release profiles when stored for 6 months in ambient room conditions, suggesting that MC and Alg are good candidates for preparing modified-release baclofen tablet formulations.
Abdelkader
Hamdy
H
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt. hamdy2002m@yahoo.com
Abdalla
Ossama Youssef
OY
Salem
Hesham
H
D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry; D001418:Baclofen / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006244:Hardness; D006245:Hardness Tests; D006603:Hexuronic Acids / Q000737:chemistry; D007700:Kinetics; D008747:Methylcellulose / Q000737:chemistry; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D006603:Hexuronic Acids; D009125:Muscle Relaxants, Central; D011108:Polymers; D013607:Tablets; D020723:Glucuronic Acid; D008747:Methylcellulose; D001418:Baclofen; D002266:Carboxymethylcellulose Sodium