Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection.
Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.
Piriou
Erwan
E
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
van Dort
Karel
K
Otto
Sigrid
S
van Oers
Marinus H J
MH
van Baarle
Debbie
D
D001402:B-Lymphocytes / Q000276:immunology; D004279:DNA, Viral / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000821:virology*; D006678:HIV / Q000254:growth & development* / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D006679:HIV Seropositivity / Q000276:immunology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D019562:Viral Load
D004279:DNA, Viral