Endovascular brachytherapy in the femoropopliteal segment using 192Ir and 188Re.
This report presents a review of the literature on endovascular brachytherapy (EVBT) after percutaneous transluminal angioplasty (PTA) in the femoropopliteal segment. We summarize the pathophysiological changes induced by PTA and EVBT within the vessel wall, technical considerations regarding various radiation sources and their application, the impact of stents on the radial dose profile, recommendations for dosimetry of beta and gamma sources, results of experimental and clinical trials, and the medication required before, during, and after EVBT. We aim to help to identify patients who are eligible for EVBT, to choose an appropriate technical approach, and to initiate adequate antiplatelet and anticoagulant therapy.
Wohlgemuth
Walter A
WA
Department of Radiology, Klinikum Augsburg, Stenglinstrasse 2, D-86156, Augsburg, Germany.
Leissner
Giesbert
G
Wengenmair
Hermann
H
Bohndorf
Klaus
K
Kirchhof
Klaus
K
D000800:Angioplasty, Balloon / Q000009:adverse effects* / Q000379:methods; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000628:therapy; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D005263:Femoral Artery / Q000528:radiation effects; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000628:therapy; D011150:Popliteal Artery / Q000528:radiation effects; D011379:Prognosis; D015641:Radiography, Interventional / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D019233:Retreatment; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014654:Vascular Patency
D007496:Iridium Radioisotopes