Not just sheer luck! Immune correlates of protection against HIV-1 infection.
Susceptibility to HIV infection is widely different among individuals, and it is known that individuals can be identified who are repeatedly exposed to HIV but in whom neither infection nor disease are seen. The possibility that sheer luck is not the only determinant of this phenomenon begun to be considered in 1989 when it was reported that T cell responses to HIV proteins could be detected in antibody-negative sexual partners of known HIV-positive men. In this review, we will summarize the body of knowledge that stemmed from that first observation.
Piacentini
Luca
L
DISP LITA Vialba, Milano, University Medical School, Milano, Italy. luca.piacentini@unimi.it
Fenizia
Claudio
C
Naddeo
Valentina
V
Clerici
Mario
M
D000071480:APOBEC-3G Deaminase; D000917:Antibody Formation; D019742:Chemokines, CC / Q000276:immunology; D003564:Cytidine Deaminase / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D018023:HIV Seronegativity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000821:virology
C414047:CCL28 protein, human; D019742:Chemokines, CC; D007070:Immunoglobulin A; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase