title: IgA nephropathy associated with leukemia and lymphoma: report of two cases.
abstract: IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years before the onset of non-Hodgkin lymphoma, and hematuria continued during chemotherapy. Each disease occurred after a long interval, and the clinical courses did not run parallel. The association was thought to be incidental in our cases. Chemotherapy with adrenocorticosteroids and immunosuppressants [6-mercaptopurine (6-MP) and cyclophosphamide (CY)] for leukemia and lymphoma did not affect the clinical course of IgAN.
authors.affiliation: Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan. motoyan@basil.ocn.ne.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Motoyama
authors.affiliation: Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kojima
authors.affiliation: Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ohara
authors.affiliation: Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
authors.forename: Ichirou
authors.initials: I
authors.lastname: Tsukimoto
authors.affiliation: Department of Pathology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ishikawa
authors.affiliation: Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Shizuoka, Japan.
authors.forename: Kikuo
authors.initials: K
authors.lastname: Iitaka
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006417:Hematuria / Q000209:etiology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure*; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D007070:Immunoglobulin A; D007166:Immunosuppressive Agents; D004176:Dipyridamole