A cleavable linker strategy for optimising enolate alkylation reactions of a polymer-supported Evans' oxazolidin-2-one.
A cleavable linker strategy has been used to optimise the enolate alkylation reactions of a recyclable L-tyrosine derived polymer-supported oxazolidin-2-one for the asymmetric synthesis of a series of chiral alpha-alkyl acids.
Green
Rachel
R
Department of Chemistry, University of Bath, Claverton Down, Bath, UK.
Merritt
Andrew T
AT
Bull
Steven D
SD
D000478:Alkylation; D009682:Magnetic Resonance Spectroscopy; D023303:Oxazolidinones / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D023303:Oxazolidinones; D011108:Polymers