Decrease in the frequency of meningeal involvement in AIDS-related systemic lymphoma in patients receiving HAART.
We evaluated the frequency of primary central nervous system lymphoma and leptomeningeal involvement in systemic non-Hodgkin's lymphoma (NHL) in HIV-infected patients. Those receiving highly active antiretroviral therapy (HAART) showed a decrease in leptomeningeal involvement in systemic NHL (0/30 vs. 12/87; p=0.023). Therefore HAART could prevent CNS involvement in systemic NHL.
Navarro
José-Tomás
JT
Vall-Llovera
Ferran
F
Mate
José-Luis
JL
Morgades
Mireia
M
Feliu
Evarist
E
Ribera
Josep-Maria
JM
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000517:prevention & control*; D008297:Male; D008578:Meninges / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors