Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets.
The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets.
Campodónico
Paola R
PR
Instituto de Ciencias, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, código postal 771-0162, Santiago, Chile. pcampodonico@udd.cl
Contreras
Renato
R
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D008956:Models, Chemical; D055672:Static Electricity; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D002241:Carbohydrates