Two new lignans from the stem bark of Magnolia obovata and their cytotoxic activity.
Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 microg/ml.
Youn
UiJoung
U
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Chen
Quan Cheng
QC
Lee
Ik Soo
IS
Kim
HongJin
H
Yoo
Jae-Kuk
JK
Lee
JongPill
J
Na
Minkyun
M
Min
Byung-Sun
BS
Bae
KiHwan
K
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002934:Cinnamates; D003374:Coumarins; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007564:Japan; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
C525791:4-methoxymagnaldehyde B; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D003374:Coumarins; D017705:Lignans; C525792:coumanolignan