Cycloartane-type triterpenoids from the resinous exudates of Commiphora opobalsamum.
Eight new cycloartane-type triterpenoids, cycloartan-24-ene-1alpha,2alpha,3alpha-triol (1), 3beta-acetoxycycloartan-24-ene-1alpha,2alpha-diol (2), 1alpha-acetoxycycloartan-24-ene-2alpha,3beta-diol (3), 3beta-isovaleroyloxycycloartan-24-ene-1alpha,2alpha-diol (4), cycloartan-24-ene-1alpha,3beta-diol (5), cycloartan-23 E-ene-1alpha,2alpha,3beta,25-tetrol (6), and an epimeric mixture of 24 R,25-epoxycycloartane-1alpha,2alpha,3beta-triol (7) and 24 S,25-epoxycycloartane-1alpha,2alpha,3beta-triol (8), together with one known compound, cycloartan-24-ene-1alpha,2alpha,3beta-triol (9), were isolated from the resinous exudates of Commiphora opobalsamum. Their structures were established on the basis of mass spectrometry and multidimensional NMR spectroscopy. The cytotoxicity of compounds 1-9 was evaluated against the PC3 and DU145 human prostate tumor cell lines. All of the compounds except 1 and 5 exhibited moderate cytotoxicity against PC3 or DU145 cells with IC50 values ranging from 10.1 to 37.2 microM.
Shen
Tao
T
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, People's Republic of China.
Yuan
Hui-Qing
HQ
Wan
Wen-Zhu
WZ
Wang
Xiao-Ling
XL
Wang
Xiao-Ning
XN
Ji
Mei
M
Lou
Hong-Xiang
HX
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029744:Commiphora / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D053147:Plant Exudates / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D053147:Plant Exudates; D014315:Triterpenes; C085352:cycloartane