XMAP215: a tip tracker that really moves.
XMAP215 is a microtubule plus-end binding protein implicated in modulating microtubule dynamics. In this issue, Brouhard et al. (2008) propose a new mechanism to explain how XMAP215 promotes microtubule growth. They report that XMAP215 moves with the growing microtubule plus ends where it catalyzes the addition of tubulin subunits.
Asbury
Charles L
CL
Department of Physiology and Biophysics, Box 357290, University of Washington, Seattle, WA 98195, USA. casbury@u.washington.edu
D000818:Animals; D001681:Biological Assay / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology; D049108:Cell Enlargement; D049452:Green Fluorescent Proteins / Q000032:analysis / Q000378:metabolism; D046911:Macromolecular Substances / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D011485:Protein Binding / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D014404:Tubulin / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*
C486738:CKAP5 protein, Xenopus; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D014404:Tubulin; D029867:Xenopus Proteins; D049452:Green Fluorescent Proteins