Molecular mechanisms of cerebral vasospasm following aneurysmal SAH.
Cerebral vasospasm following aneurysmal vasospasm has been the subject of intensive research. However the underlying pathophysiological mechanisms remain obscure. This article should summarize the present state concerning smooth muscle contraction, endothelial dysfunction, inflammatory changes, gene expression, in the genesis of vasospasm following aneurysmal subarachnoid hemorrhage.
Rothoerl
Ralf Dirk
RD
Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ralf.rothoerl@lrz.tum.de
Ringel
Florian
F
D000818:Animals; D002536:Cerebral Arteries / Q000378:metabolism / Q000503:physiopathology*; D042783:Endothelial Cells / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D020301:Vasospasm, Intracranial / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*
D018836:Inflammation Mediators