[Association between p53 gene codon 72 polymorphism and keloid in Chinese population].
OBJECTIVE
To investigate the relationship between p53 gene codon 72 polymorphism and genetic predisposition to keloid in Chinese population.


METHODS
PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect p53 gene codon 72 genotypes of 60 keloid samples and 102 whole blood samples from healthy controls in China.


RESULTS
There was no significant difference in the distribution of p53 gene codon 72 polymorphism between the keloid patients and the healthy controls (X2 = 2.910, P = 0.233), nor did the frequencies for Pro and Arg alleles (X2 = 0.882, P = 0.348), and there was no significant difference in the distribution of p53 gene codon 72 polymorphism in keloid patients and normal controls from China and Japan respectively (X2 = 3.942, P = 0.139; X2 = 3.260, P = 0.196). But the Arg/Arg genotype was significantly higher than the Pro/Pro genotype among the patients with keloid in shoulder and back (P < 0.01).


CONCLUSIONS
There was no significant association between the distribution of p53 gene codon 72 polymorphism and keloid in Chinese population, but Arg/Arg genotype may affect the formation of keloids in shoulder and back compared to others. Further research should be done to investigate the relationship between p53 gene codon 72 polymorphism and keloids in different sites.
Yan
Li
L
Plastic Surgery Hospital, Chinese Academy of Medical Science, Beijing, China.
Lü
Xiao-yan
XY
Wang
Chun-mei
CM
Cao
Rui
R
Yin
Yan-hua
YH
Jia
Chun-shi
CS
Zhuang
Qiang
Q
D044466:Asian People / Q000235:genetics; D003062:Codon / Q000235:genetics*; D005260:Female; D006801:Humans; D007627:Keloid / Q000235:genetics*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D003062:Codon; D016159:Tumor Suppressor Protein p53