title: [Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis].
abstract: OBJECTIVE
  To investigate the expression of alpha-smooth muscle action (alpha-SMA) in the renal tubulointerstitium in patients with kidney collateral stasis.
  
  
  METHODS
  The expression of alpha-SMA in the renal biopsy specimens from 54 patients with kidney collateral stasis was examined by immunohistochemical method.
  
  
  RESULTS
  The degree of kidney collateral stasis was increased with the increasing of the degree of renal interstitial fibrosis (P<0.05), and there was significant positive correlation between kidney collateral stasis and alpha-SMA expression (P<0.05).
  
  
  CONCLUSIONS
  Kidney collateral stasis is one of the main reasons of renal fibrosis. With the increasing of kidney collateral stasis, MFBs in the renal interstitium proliferate obviously, becoming one of the most important causes of renal interstitial fibrosis.
authors.affiliation: Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi Province 710032, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: DU
authors.forename: Qing
authors.initials: Q
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Guang-Lei
authors.initials: GL
authors.lastname: Chen
mesh_terms: D000199:Actins / Q000032:analysis / Q000378:metabolism*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000378:metabolism*; D011379:Prognosis
chemical_list: C541116:ACTA2 protein, human; D000199:Actins