Electrochemical determination of the antidiabetic drug repaglinide.
The electrochemical oxidation of repaglinide has been carried out in Britton-Robinson buffer at carbon paste and glassy carbon electrodes. Repaglinide exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). Differential pulse voltammetry was used to determine repaglinide in pure form. The peak current varied linearly in the following ranges: 8.0 x 10(-7)-3.2 x 10(-6) M and 4.0 x 10(-7)-4.0 x 10(-6) M in case of carbon paste electrode and glassy carbon electrode, respectively. In case of carbon paste electrode the limits of detection (LOD) and quantification (LOQ) were 1.348 x 10(-7) M and 4.494 x 10(-7) M, respectively. For glassy carbon electrode the LOD and LOQ were 1.062 x 10(-7) M and 3.54 x 10(-7) M, respectively. The percentage recoveries were found in the following ranges: 99.09-100.07% and 99.0-100.50% for carbon paste electrode and glassy carbon electrode, respectively. The relative standard deviations were found in the following ranges: 0.636-1.395% and 0.431-1.104% in case of carbon paste electrode and glassy carbon electrode, respectively. Differential pulse voltammetry was successfully applied for the determination of repaglinide in tablets and human serum.
El-Ries
Mohamed Abdel Nabi
MA
National Organization for Drug Control and Research, Cairo, Egypt. mohamedelries@hotmail.com
Mohamed
Gehad Genidy
GG
Attia
Ali Kamal
AK
D002219:Carbamates / Q000032:analysis* / Q000097:blood; D002244:Carbon; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000097:blood; D010084:Oxidation-Reduction; D010880:Piperidines / Q000032:analysis* / Q000097:blood; D013607:Tablets / Q000737:chemistry
D002219:Carbamates; D007004:Hypoglycemic Agents; D010880:Piperidines; D013607:Tablets; C072379:repaglinide; D002244:Carbon