title: Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.
abstract: We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV-positive patients after the development of lamivudine resistance.
authors.affiliation: BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Sonia
authors.initials: S
authors.lastname: Gutiérrez
authors.forename: Silvia
authors.initials: S
authors.lastname: Guillemi
authors.forename: Natalie
authors.initials: N
authors.lastname: Jahnke
authors.forename: Valentina
authors.initials: V
authors.lastname: Montessori
authors.forename: P Richard
authors.initials: PR
authors.lastname: Harrigan
authors.forename: Julio S G
authors.initials: JS
authors.lastname: Montaner
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D024882:Drug Resistance, Viral; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D018451:Homosexuality, Male; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage* / Q000009:adverse effects; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology*; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage* / Q000009:adverse effects; D000068698:Tenofovir; D000637:Transaminases / Q000378:metabolism; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D019259:Lamivudine; D000068698:Tenofovir; D000637:Transaminases; D000225:Adenine