Childhood onset demyelination and Graves' disease: shared antigen or autoimmune clustering?
We describe a case of concomitant Graves' disease and demyelination, with optic neuritis and cerebellar dysfunction, in an adolescent girl. Autoimmune thyroid disease with encephalopathy is the hallmark of Hashimoto's encephalopathy, linking thyroid and central nervous system dysfunction. However, to our knowledge, Graves' disease has not been previously reported in association with clinically isolated demyelinating disease in childhood.
Mitchell
Rebecca S
RS
Department of Medicine, Division of Endocrinology and Metabolism, University of Alberta, Edmonton, Canada. rebeccam@ualberta.ca
Yager
Jerome Y
JY
Marks
Seth D
SD
D013956:Antithyroid Agents / Q000627:therapeutic use; D001324:Autoantigens / Q000276:immunology*; D001921:Brain / Q000473:pathology; D002648:Child; D016000:Cluster Analysis; D003711:Demyelinating Diseases / Q000276:immunology* / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008713:Methimazole / Q000627:therapeutic use; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology
D013956:Antithyroid Agents; D001324:Autoantigens; D008713:Methimazole