title: Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.
abstract: Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs.
authors.affiliation: Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Suhara
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hirota
authors.forename: Kimie
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Maya
authors.initials: M
authors.lastname: Kamao
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsugawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Okano
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D013329:Structure-Activity Relationship; D024482:Vitamin K 2 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D024482:Vitamin K 2