title: Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration.
abstract: The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.
authors.affiliation: Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Xianyou
authors.initials: X
authors.lastname: Wang
authors.forename: Baoan
authors.initials: B
authors.lastname: Song
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Pinaki S
authors.initials: PS
authors.lastname: Bhadury
authors.forename: Kai
authors.initials: K
authors.lastname: Yan
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: Song
authors.initials: S
authors.lastname: Zeng
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry*; D003487:Cyanoacrylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008872:Microwaves; D010935:Plant Diseases / Q000821:virology; D018515:Plant Leaves / Q000821:virology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D003487:Cyanoacrylates