Practical, scalable, high-throughput approaches to eta3-pyranyl and eta3-pyridinyl organometallic enantiomeric scaffolds using the Achmatowicz reaction.
A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and TpMo(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.
Coombs
Thomas C
TC
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
Lee
Maurice D
MD
Wong
Heilam
H
Armstrong
Matthew
M
Cheng
Bo
B
Chen
Wenyong
W
Moretto
Alessandro F
AF
Liebeskind
Lanny S
LS
D001372:Aza Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D007536:Isomerism; D047028:Macrocyclic Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013696:Temperature
D001372:Aza Compounds; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D011725:Pyridines; C023666:pyridine