title: Serum markers of systemic right ventricular function and exercise performance.
abstract: The right ventricle, which faces systemic pressure due to congenital heart disease, often develops premature systolic dysfunction. Cardiac hormones might be useful to identify patients with such systolic dysfunction. This prospective study investigated the relationship of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels with right ventricular ejection fraction (RVEF) and exercise performance in patients with a systemic right ventricle. ANP levels were obtained in 24 patients and BNP levels were obtained in 22 patients with systemic right ventricle. Patients underwent exercise study (n = 22) and cardiovascular magnetic resonance imaging (n = 11) or equilibrium radionuclide angiography (n = 13) to determine RVEF. There were 17 patients with complete transposition and 7 patients with corrected transposition. ANP showed an inverse correlation with RVEF (r2 = 0.63, p < 0.001), a weak but statistically significant inverse correlation with exercise duration (r2 = 0.18, p = 0.047) and no relationship with maximal oxygen consumption (peak V'O2) (r2 = 0.10, p = NS). BNP did not show a relationship with any of the parameters measured. ANP shows a strong inverse correlation with RVEF and a weak correlation with exercise duration in patients with a systemic right ventricle. BNP does not show a significant relationship when compared with either parameter. ANP might be a useful tool for identification of systolic right ventricular dysfunction.
authors.affiliation: Division of Cardiology, Department of Pediatrics, Columbus Children's Hospital, Columbus, OH 43205, USA. ruchira.garg@mch.com
authors.forename: Ruchira
authors.initials: R
authors.lastname: Garg
authors.forename: Subha V
authors.initials: SV
authors.lastname: Raman
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Hoffman
authors.forename: John
authors.initials: J
authors.lastname: Hayes
authors.forename: Curt J
authors.initials: CJ
authors.lastname: Daniels
mesh_terms: D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D017079:Exercise Tolerance; D006330:Heart Defects, Congenital / Q000097:blood / Q000150:complications; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018497:Ventricular Dysfunction, Right / Q000097:blood* / Q000209:etiology; D016278:Ventricular Function, Right
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor