Biofilm formation in Acinetobacter baumannii: associated features and clinical implications.
Biofilm formation in 92 unrelated strains of Acinetobacter baumannii isolated in a multicentre cohort study was investigated using a microtitre plate assay. Fifty-six (63%) isolates formed biofilm. These isolates were less frequently resistant to imipenem or ciprofloxacin than were non-biofilm-forming isolates (25% vs. 47%, p 0.04; and 66% vs. 94%, p 0.004, respectively). All catheter-related urinary or bloodstream infections and the sole case of shunt-related meningitis were caused by biofilm-forming strains. Multivariate analysis revealed that treatment in an intensive care unit, ciprofloxacin resistance and isolation from a respiratory sample were associated with non-biofilm-forming isolates, while previous aminoglycoside use was associated with biofilm-forming isolates.
Rodríguez-Baño
J
J
Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, Spain. jrb@nacom.es
Martí
S
S
Soto
S
S
Fernández-Cuenca
F
F
Cisneros
J M
JM
Pachón
J
J
Pascual
A
A
Martínez-Martínez
L
L
McQueary
C
C
Actis
L A
LA
Vila
J
J
D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000502:physiology*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology; D018441:Biofilms / Q000254:growth & development*; D002408:Catheters, Indwelling / Q000009:adverse effects; D002939:Ciprofloxacin / Q000494:pharmacology; D015331:Cohort Studies; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008297:Male; D008581:Meningitis / Q000382:microbiology; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D015378:Imipenem