title: Isolated B-cell lymphoproliferative disorder at the dura mater with B-cell chronic lymphocytic leukemia immunophenotype.
abstract: Lymphoma manifestations of the dura mater are extremely rare and have mostly been attributed to extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type. We report a patient with an isolated meningeal tumor, identified as a B-cell lymphoproliferative disorder with typical B-cell chronic lymphocytic leukemia immunophenotype. Because of the subclinical detection of trisomy 3 in the bone marrow by cytogenetic analysis and interphase fluorescence in situ hybridization, CD5(+) MALT is an important differential diagnosis; however, to our knowledge, this entity has never been reported in the context of dural lymphoma.
authors.affiliation: Department of Hematology, Oncology and Transfusion Medicine, Charité Campus Benjamin Franklin, Berlin, Germany. philipp.kiewe@charite.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Kiewe
authors.forename: Friederike E
authors.initials: FE
authors.lastname: Dallenbach
authors.forename: Lars
authors.initials: L
authors.lastname: Fischer
authors.forename: Stefan
authors.initials: S
authors.lastname: Hoecht
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kombos
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thiel
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korfel
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D054066:Leukemia, Large Granular Lymphocytic / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008297:Male