[Changes of plasma CD40L and PAPP-A in patients with acute coronary syndrome after the PCI operation].
OBJECTIVE
To observe the changes and significance of plasma CD40L and pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI) operation.


METHODS
According to the occurrence of primary heart events or restenosis 6 months after the PCI, 68 patients were divided into the ACS group and the stable angina pectoris (SAP) group. Plasma CD40L and PAPP-A after the PCI operation were measured and compared. Thirty-six patients underwent repeated angiography after the PCI. Their baseline and follow up angiograms were compared by quantitative coronary angiography to assess the incidence of restenosis.


RESULTS
CD40L and PAPP-A after the PCI operation were higher in the ACS group than that in the SAP group.The group having primary heart events within 6 months had higher level of PAPP-A after the PCI. The group having restenosis 6 months had higher level of PAPP-A after the PCI. The change of later loss index of coronary artery lumen diameter was correlated with PAPP-A level after the PCI.


CONCLUSIONS
CD40L and PAPP-A were higher in the ACS group, indicating the possible mechanism by which CD40L facilitates the plaque rupture via up-regulating the PAPP-A expression.Plasma PAPP-A level after the PCI possibly for cases the occurrence of primary heart events or restenosis within 6 months.
Li
Xu-ping
XP
Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. lixp0711@126.com
Zhou
Sheng-hua
SH
Tang
Jian-zhun
JZ
Liu
Qi-ming
QM
Fang
Zhen-fei
ZF
Hu
Xin-qun
XQ
Zhou
Tao
T
Shen
Xiang-qian
XQ
Qi
Shu-shan
SS
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011184:Postoperative Period; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*
D023201:CD40 Ligand; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human