Cationic palladium(II)-catalyzed stereoselective glycosylation with glycosyl trichloroacetimidates.
The development of a new method for stereoselective glycosylation with glycosyl trichloroacetimidate donors employing cationic palladium(II), Pd(CH(3)CN)(4)(BF(4))(2), is described. This process employs Pd(CH(3)CN)(4)(BF(4))(2) as an efficient activator, providing access to a variety of disaccharides and glycopeptides. This reaction is highly stereoselective and proceeds under mild conditions with low catalyst loading. Interestingly, this palladium catalysis directs beta-glucosylations in the absence of classical neighboring group participation.
Yang
Jaemoon
J
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, USA.
Cooper-Vanosdell
Colleen
C
Mensah
Enoch A
EA
Nguyen
Hien M
HM