title: Subacute toxicity of colistin methanesulfonate in rats: comparison of various intravenous dosage regimens.
abstract: The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.
authors.affiliation: Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Wallace
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: Craig R
authors.initials: CR
authors.lastname: Rayner
authors.forename: David
authors.initials: D
authors.lastname: Taylor
authors.forename: Deborah
authors.initials: D
authors.lastname: Middleton
authors.forename: Robert W
authors.initials: RW
authors.lastname: Milne
authors.forename: Kingsley
authors.initials: K
authors.lastname: Coulthard
authors.forename: John D
authors.initials: JD
authors.lastname: Turnidge
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001522:Behavior, Animal / Q000187:drug effects; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced; D008698:Mesylates / Q000008:administration & dosage / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D008698:Mesylates; C045880:methanesulfonic acid; D003091:Colistin