[Serological markers of chronic Chlamydia pneumoniae and cytomegalovirus (CMV) infection in patients with peripheral occlusive artery disease--an initial report].
Involvement of infection agents in pathogenesis of atherosclerosis was described in several studies, particularly in patients with acute coronary syndrome or ischemic stroke. However, in very few studies an association of serological markers of chronic infection with peripheral occlusive artery disease was analysed. The prevalence and concentration of immunoglobulin G and A to Chlamydia pneumoniae and immunoglobulin G to CMV were measured in sera of 31 participants suffering from peripheral occlusive artery disease. Significant difference in the prevalance of immunoglobulin G to C. pneumoniae and CMV between study and control groups was documented. There was no such association in reference to immunoglobulin A to C. pneumoniae index. Serum concentration of all measured antibodies were significantly higher in the study group than in control.
Rabczyński
Maciej
M
Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii Akademii Medyczne, Wrocław. maciejrabczynski@poczta.onet.pl
Jakobsche
Urszula
U
Adamiec
Rajmund
R
D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001157:Arterial Occlusive Diseases / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification / Q000472:pathogenicity; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000302:isolation & purification / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003925:Diabetic Angiopathies / Q000276:immunology / Q000382:microbiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G