The effect of ABO blood group on von Willebrand response to exercise.
Individuals of O blood group have significantly lower plasma levels of either Factor VIII (FVIII) or the von Willebrand factor (vWF). Conversely, there is accumulating evidence that elevated FVIII-vWF levels may represent an important risk factor for ischemic heart and venous thromboembolic disease. In this study, individuals exercised for 20 minutes at 10% below the first ventilatory threshold (aerobic threshold), which corresponds to 48% of maximum oxygen uptake. People with non-O blood group show higher resting and postexercise vWF levels compared with those of O blood group, as evidenced by a lower maximal heart rate. The groups were compared using the ANOVA one-way test, and a P < 0.05 was considered statistically significant. These results could change the way in which exercise training is designed for both healthy and sick individuals because O group individuals could have a more thrombogenic response to exercise.
Ribeiro
Jerri L
JL
Exercise Research Laboratory, Physical Education School, Federal University of Rio Grande do Sul, Brazil. jerriribeiro@yahoo.com.br
Salton
Gabriele D
GD
Bandinelli
Eliane
E
Oliveira
Alvaro R
AR
Roisenberg
Israel
I
D000017:ABO Blood-Group System; D000328:Adult; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008297:Male; D014841:von Willebrand Factor / Q000032:analysis*
D000017:ABO Blood-Group System; D014841:von Willebrand Factor