Idiopathic short stature: definition, epidemiology, and diagnostic evaluation.
Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, and according to pubertal delay. It should be differentiated from dysmorphic syndromes, skeletal dysplasias, short stature secondary to a small birth size (small for gestational age, SGA), and systemic and endocrine diseases. ISS is the diagnostic group that remains after excluding known conditions in short children.
Wit
J M
JM
Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. j.m.wit@lumc.nl
Clayton
P E
PE
Rogol
A D
AD
Savage
M O
MO
Saenger
P H
PH
Cohen
P
P
D001827:Body Height / Q000502:physiology; D003940:Diagnostic Techniques, Endocrine; D006130:Growth Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006801:Humans; D025202:Molecular Diagnostic Techniques