Primary somatosensory evoked magnetic fields elicited by sacral surface electrical stimulation.
To explore the brain response to sacral surface therapeutic electrical stimulation (SSTES) for the treatment of refractory urinary incontinence and frequent micturition, evoked magnetic fields were measured in six healthy males. Electrical stimuli were applied between bilateral surface electrodes over the second through fourth posterior sacral foramens with intensity just below the pain threshold. Somatosensory evoked magnetic fields (SEFs) for the bilateral median (MN) and posterior tibial nerves (PTN) were also measured for the comparison. Sources of the early SEF peaks were superimposed on individual magnetic resonance images. The first peak latency for sacral stimuli, M30, occurred at 30.2+/-0.8 ms (mean+/-standard deviation, N=6), with shorter latency than those for PTN stimulus (39.3+/-1.4 ms, N=12) and longer latency than those for MN stimulus (21.0+/-0.9 ms, N=12). The second peak latency for sacral stimuli, M50, occurred at 47.2+/-2.9 ms (N=6). Both M30 and M50 peaks showed a single dipole pattern over the vertex in the isofield maps. The equivalent current dipoles of M30 and M50 were both estimated near the medial end of the central sulcus with approximately posterior current direction. These results suggest that the sacral M30 and M50 are responses from the primary somatosensory cortex. The relatively long time lag between the onset and peak of M30 suggests that SSTES directly affects both the cauda equina and cutaneous nerve of the sacral surface.
Matsushita
Mabumi
M
Department of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan. mabumi@uro.med.tohoku.ac.jp
Nakasato
Nobukazu
N
Nakagawa
Haruo
H
Kanno
Akitake
A
Kaiho
Yasuhiro
Y
Arai
Yoichi
Y
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology*; D001415:Back / Q000294:innervation; D001931:Brain Mapping; D002420:Cauda Equina / Q000502:physiology; D004599:Electric Stimulation Therapy / Q000379:methods*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D006801:Humans; D008160:Lumbosacral Plexus / Q000033:anatomy & histology / Q000502:physiology*; D015225:Magnetoencephalography; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009431:Neural Conduction / Q000502:physiology; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D013997:Time Factors; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology; D014549:Urinary Incontinence / Q000503:physiopathology / Q000628:therapy*