N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging.
This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37 degrees C. Nearly 8.53 +/- 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.
Bhattarai
Shanta R
SR
Department of Textile Engineering, Chonbuk National Univiversity, Jeonju, South Korea. khy@chonbuk.ac.kr.
Kc
Remant B
RB
Kim
Sun Y
SY
Sharma
Manju
M
Khil
Myung S
MS
Hwang
Pyoung H
PH
Chung
Gyung H
GH
Kim
Hak Y
HY