title: Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.
abstract: The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.
authors.affiliation: Pharmacokinetic and Pharmacogenetic Unit, Hospital Carlos III, Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodríguez-Nóvoa
authors.forename: Pilar
authors.initials: P
authors.lastname: García-Gascó
authors.forename: Francisco
authors.initials: F
authors.lastname: Blanco
authors.forename: Gema
authors.initials: G
authors.lastname: González-Pardo
authors.forename: Carol
authors.initials: C
authors.lastname: Castellares
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Jiménez-Nácher
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D015224:Dideoxynucleosides / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005820:Genetic Testing; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011237:Predictive Value of Tests; D013030:Spain; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen