title: Regional skeletal bone deficit in female adolescents with anorexia nervosa: influence of the degree of malnutrition and weight recovery in a two year longitudinal study.
abstract: OBJECTIVE
  To analyze changes in bone mineral density (BMD) and the effect of weight recovery on the restoration of bone mass in adolescent females with anorexia nervosa (AN) with moderate malnutrition.
  
  
  METHODS
  We evaluated lumbar and femoral BMD in 27 females with restrictive AN with malnutrition and amenorrhea for over (M+PA) or less than (M+SA) one year and 12 with normal nutrition and amenorrhea for over one year (N+PA) followed for 24 months.
  
  
  RESULTS
  BMI remained below -1.5 SD in M+PA and increased at 24 months in M+SA. M+PA had low lumbar and femoral neck BMD at diagnosis, decreasing at 24 months. Lumbar BMD in N+PA and M+SA was reduced, with an increase in M+SA at 24 months.
  
  
  CONCLUSIONS
  Moderate malnutrition in AN induces loss of bone mass at the lumbar and femoral levels. Weight gain and resumption of menses increases bone mass, especially in the lumbar spine.
authors.affiliation: Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Madrid, Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: García-De Alvaro
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Muñoz-Calvo
authors.forename: Guillermo
authors.initials: G
authors.lastname: Martínez
authors.forename: Vicente
authors.initials: V
authors.lastname: Barrios
authors.forename: Federico
authors.initials: F
authors.lastname: Hawkins
authors.forename: Jesús
authors.initials: J
authors.lastname: Argente
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology / Q000378:metabolism; D000856:Anorexia Nervosa / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D044342:Malnutrition / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D011446:Prospective Studies; D011859:Radiography; D015430:Weight Gain