title: Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation.
abstract: Both the microdosimetric kinetic model (MKM) and the local effect model (LEM) can be used to calculate the surviving fraction of cells irradiated by high-energy ion beams. In this study, amorphous track structure models instead of the stochastic energy deposition are used for the MKM calculation, and it is found that the MKM calculation is useful for predicting the survival curves of the mammalian cells in vitro for (3)He-, (12)C- and (20)Ne-ion beams. The survival curves are also calculated by two different implementations of the LEM, which inherently used an amorphous track structure model. The results calculated in this manner show good agreement with the experimental results especially for the modified LEM. These results are compared to those calculated by the MKM. Comparison of the two models reveals that both models require three basic constituents: target geometry, photon survival curve and track structure, although the implementation of each model is significantly different. In the context of the amorphous track structure model, the difference between the MKM and LEM is primarily the result of different approaches calculating the biological effects of the extremely high local dose in the center of the ion track.
authors.affiliation: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan. y_kase@nirs.go.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kase
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Kanai
authors.forename: Naruhiro
authors.initials: N
authors.lastname: Matsufuji
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Furusawa
authors.forename: Thilo
authors.initials: T
authors.lastname: Elsässer
authors.forename: Michael
authors.initials: M
authors.lastname: Scholz
mesh_terms: D000818:Animals; D001703:Biophysics / Q000706:statistics & numerical data; D002244:Carbon; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D063193:Heavy Ion Radiotherapy; D006371:Helium; D006801:Humans; D007554:Isotopes; D008954:Models, Biological; D009356:Neon; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011336:Probability; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D007554:Isotopes; D006371:Helium; D009356:Neon; D002244:Carbon