title: Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
abstract: The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively. The rate of occurrence of SCT in the cryptorchid testis was very high (71%). The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis. The mean SOD activity in cryptorchid testes and SCTs was significantly lower and higher, respectively, than in normal testes (both P<0.01). The mean HSP 70 concentration in both cryptorchid testes and SCTs was significantly higher than in normal testes (both P<0.01). The mean plasma INH-alpha concentration of the cryptorchid and SCT dogs was significantly lower and higher, respectively, than in normal dogs (P<0.05 and 0.01, respectively). The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.
authors.affiliation: Laboratory of Veterinary Reproduction, Nippon Veterinary and Life Science University, Kyonan-cho, Tokyo, Japan. kawakami@nvlu.ac.jp
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kawakami
authors.forename: Taichi
authors.initials: T
authors.lastname: Hirano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hori
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tsutsui
mesh_terms: D000818:Animals; D003456:Cryptorchidism / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D007265:Inhibins / Q000097:blood*; D008297:Male; D012707:Sertoli Cell Tumor / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013737:Testis / Q000201:enzymology / Q000378:metabolism*
chemical_list: D018840:HSP70 Heat-Shock Proteins; C094377:inhibin-alpha subunit; D007265:Inhibins; D013482:Superoxide Dismutase