Walsucochins A and B with an unprecedented skeleton isolated from Walsura cochinchinensis.
Walsucochins A (1) and B (2) with an unprecedented skeleton were isolated from Walsura cochinchinensis. Their structures including absolute configuration were elucidated by spectral methods. A biosynthetic pathway of 1 and 2 was postulated. Both 1 and 2 exhibited significant cell protecting activities against H2O2-induced PC12 cell damage.
Zhou
Zhi-Wang
ZW
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Yin
Sheng
S
Zhang
Hai-Yan
HY
Fu
Yan
Y
Yang
Sheng-Ping
SP
Wang
Xiao-Ning
XN
Wu
Yan
Y
Tang
Xi-Can
XC
Yue
Jian-Min
JM
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D016716:PC12 Cells; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D014315:Triterpenes; C527907:walsucochin A; C527908:walsucochin B; D006861:Hydrogen Peroxide