title: Hashimoto's thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease.
abstract: Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents in iodine replete areas. To find out the clinical, epidemiological and laboratory characteristics of the disease in childhood, we reviewed files of 162 children and adolescents with HT followed in the Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine.
  
  
  RESULTS
  Female patients constituted 86.4% (n = 140) of all patients with a female:male ratio of 6.4. Mean age at diagnosis was 11.4 +/- 2.97 years (age range 4.4-16.5 years). At the time of diagnosis 43.2% of the patients (n = 70) were euthyroid, 24.1% (n = 39) had subclinical hypothyroidism, 21% (n = 34) had overt hypothyroidism, and 8.6% (n = 14) had overt and 3.1% (n = 5) subclinical hyperthyroidism.
  
  
  CONCLUSIONS
  Autoimmune thyroiditis is more frequent in females, and increases in frequency over age during childhood and adolescence. At the time of diagnosis, frequency of overt and subclinical hypothyroidism is similar to that of euthyroid goiter.
authors.affiliation: Department of Pediatrics, Division of Endocrinology, Hacettepe University Faculty ofMedicine, Ankara, Turkey. dr_huseyin@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Demirbilek
authors.forename: N
authors.initials: N
authors.lastname: Kandemir
authors.forename: E N
authors.initials: EN
authors.lastname: Gonc
authors.forename: A
authors.initials: A
authors.lastname: Ozon
authors.forename: A
authors.initials: A
authors.lastname: Alikasifoglu
authors.forename: N
authors.initials: N
authors.lastname: Yordam
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006042:Goiter / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D050031:Hashimoto Disease / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D007037:Hypothyroidism / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D007455:Iodine / Q000652:urine; D008297:Male; D012016:Reference Values; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013972:Thyrotropin; D007455:Iodine