Antimicrobial fragments of the pro-region of cathelicidins and other immune peptides.
In addition to the numerous cathelicidin peptides that are associated with the antimicrobial activity exhibited by a crude extract from ovine blood, a further three peptides with antimicrobial activity have been identified. These were part of the precursor cathelin domain of cathelicidins, a large fragment of platelet factor 4 and a small peptide similar to signal peptide of the T-cell glycoprotein CD4 precursor. Fragments of proteins that are involved in protecting the host from infection may have a secondary purpose as antimicrobial agents once they have carried out their primary purpose and are cleaved the main protein.
Anderson
Rachel C
RC
Biotechnology Group, Institute of Technology and Engineering, College of Sciences, Massey University, Private Bag 11-222, Palmerston North, New Zealand.
Rehders
Maren
M
Yu
Pak-Lam
PL
D000595:Amino Acid Sequence; D000818:Animals; D015704:CD4 Antigens / Q000737:chemistry; D054804:Cathelicidins / Q000097:blood* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000737:chemistry; D010978:Platelet Factor 4 / Q000737:chemistry; D011498:Protein Precursors; D012756:Sheep
D015704:CD4 Antigens; D054804:Cathelicidins; D011498:Protein Precursors; D010978:Platelet Factor 4