title: Targeting ACE and ECE with dual acting inhibitors.
abstract: A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.
authors.affiliation: Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-Ville, Montréal, QB, Canada. stephen.hanessian@umontreal.ca
authors.forename: Stephen
authors.initials: S
authors.lastname: Hanessian
authors.forename: Sébastien
authors.initials: S
authors.lastname: Guesné
authors.forename: Ludivine
authors.initials: L
authors.lastname: Riber
authors.forename: Julien
authors.initials: J
authors.lastname: Marin
authors.forename: Alain
authors.initials: A
authors.lastname: Benoist
authors.forename: Philippe
authors.initials: P
authors.lastname: Mennecier
authors.forename: Alain
authors.initials: A
authors.lastname: Rupin
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Verbeuren
authors.forename: Guillaume
authors.initials: G
authors.lastname: De Nanteuil
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D000072396:Endothelin-Converting Enzymes; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D009281:Naphthalenes; C527344:SA6817; D014508:Urea; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; D000072396:Endothelin-Converting Enzymes