Does anticholinergic medication have a role in treating men with overactive bladder and benign prostatic hyperplasia?
This review discusses the available evidence concerning the use of anticholinergic drugs, alone or in combination with alpha-adrenoceptor antagonists, in men with lower urinary tract symptoms due to benign prostatic hyperplasia, benign prostatic enlargement, or benign prostatic obstruction and concomitant overactive bladder syndrome. We emphasize the safety and efficacy of anticholinergic agents in treating men with benign prostatic obstruction. Several recent studies of men with an overactive bladder suggest that combination therapy of anticholinergic and alpha-adrenoceptor antagonists improves the symptoms effectively without increasing the incidence of acute urinary retention.
Lee
Kyu-Sung
KS
Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea. ks63.lee@samsung.com
Lee
Hye Won
HW
Han
Deok Hyun
DH
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D018680:Cholinergic Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology
D000317:Adrenergic alpha-Antagonists; D018680:Cholinergic Antagonists