Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?
This review addresses the role of adult hippocampal neurogenesis and stem cells in some of the most common neurodegenerative disorders and their related animal models. We discuss recent literature in relation to Alzheimer's disease and dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, alcoholism, ischemia, epilepsy and major depression.
Thompson
A
A
Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Boekhoorn
K
K
Van Dam
A-M
AM
Lucassen
P J
PJ
D000328:Adult; D000818:Animals; D001921:Brain / Q000473:pathology; D002455:Cell Division; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000473:pathology*; D009474:Neurons / Q000473:pathology*