[Analysis of the densitometric method of hand bone radiograms and assessment of early changes of bone structure in the children with Gaucher's disease on enzyme replacement therapy (ERT)].
In the study of changes of bone structure eighteen children with Gaucher's disease (ERT) at the 4 to 19,8 years, used was densitometric in vivo method of hand bone radiograms. On the basis of the radiogram assessed was the bone age of patient also optical bone density and dimension in the second metacarpal bone. Differential diagnostics was produced based on standardized cortical thickness and optical bone density, according to the norm of Polish population (1989, 2004). The analysis of hand bone radiograms in children with Gaucher's (ERT) shows that 55.5% of patients had normal skeletal status, 38.8% indicated osteopenia traits, one patient had osteoporotic traits.
Łyson-Wojciechowska
Grazyna
G
Pracownia Antropologii Kliniki Pediatrii Instytutu Pomnik-Centrum Zdrowia Dziecka, Warsaw.
Skawiński
Waldemar
W
Tylki-Szymańska
Anna
A
D015502:Absorptiometry, Photon / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000365:Age Determination by Skeleton; D015519:Bone Density / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D057487:Enzyme Therapy; D004798:Enzymes / Q000494:pharmacology; D005240:Feasibility Studies; D005260:Female; D005776:Gaucher Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005962:Glucosylceramidase / Q000494:pharmacology / Q000627:therapeutic use; D050276:Hand Bones / Q000000981:diagnostic imaging* / Q000187:drug effects; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging; D012720:Severity of Illness Index
D004798:Enzymes; D005962:Glucosylceramidase; C090568:imiglucerase