The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse.
The sense of taste informs the body about the quality of ingested foods. Tastant-mediated signals are generated by a rise in free intracellular calcium levels ([Ca(2+)]i) in the taste bud cells and then are transferred to the gustatory area of brain via connections between the gustatory nerves (chorda tympani and glossopharyngeal nerves) and the nucleus of solitary tract in the brain stem. We have recently shown that lingual CD36 contributes to fat preference and early digestive secretions in the mouse. We show here that 1) the induction of an increase in [Ca(2+)]i by linoleic acid is CD36-dependent in taste receptor cells, 2) the spontaneous preference for or conversely conditioned aversion to linoleic acid requires intact gustatory nerves, and 3) the activation of gustatory neurons in the nucleus of the solitary tract elicited by a linoleic acid deposition on the tongue in wild-type mice cannot be reproduced in CD36-null animals. We conclude that the CD36-mediated perception of long-chain fatty acids involves the gustatory pathway, suggesting that the mouse may have a "taste" for fatty foods. This system would constitute a potential physiological advantage under conditions of food scarcity by leading the mouse to select and absorb fatty foods. However, it might also lead to a risk of obesity and associated diseases in a context of constantly abundant food.
Gaillard
Dany
D
Physiologie de la Nutrition, UMR INSERM U866, ENSBANA-Université de Bourgogne, 1, Esplanade Erasme F-21000, Dijon, France.
Laugerette
Fabienne
F
Darcel
Nicolas
N
El-Yassimi
Abdelghani
A
Passilly-Degrace
Patricia
P
Hichami
Aziz
A
Khan
Naim Akhtar
NA
Montmayeur
Jean-Pierre
JP
Besnard
Philippe
P
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D018955:CD36 Antigens / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002814:Chorda Tympani Nerve / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D004041:Dietary Fats; D005227:Fatty Acids / Q000378:metabolism*; D005518:Food Preferences; D016762:Genes, fos / Q000187:drug effects; D005930:Glossopharyngeal Nerve / Q000502:physiology*; D019787:Linoleic Acid / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009829:Oleic Acids / Q000494:pharmacology; D019308:Palmitic Acid / Q000494:pharmacology; D017552:Solitary Nucleus / Q000502:physiology; D013388:Succinimides / Q000494:pharmacology; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000187:drug effects / Q000502:physiology*
D018955:CD36 Antigens; D004041:Dietary Fats; D005227:Fatty Acids; D009829:Oleic Acids; D013388:Succinimides; C120556:sulfo-N-succinimidyl oleate; D019308:Palmitic Acid; D019787:Linoleic Acid; D002118:Calcium