Babesia: the protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice.
In the present study, we investigated the protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice. Pre-treatment with "EqStim" (a commercially available immunostimulant containing killed P. acnes) showed significant resistance to both infections. To elucidate the immunological status in the mice, the concentrations of multiple cytokines were measured in serum collected from infected mice. After B. microti infection, the levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12p70, and tumor necrosis factor (TNF)-alpha in the treated group were significantly lower than in the control group. In contrast, after B. rodhaini infection, only IL-12p70 and TNF-alpha were detectable at significantly higher levels in the treated group than in the control group. The present findings indicated the protective effects of killed P. acnes on rodent babesiosis even with different immune responses between the B. microti and B. rodhaini infections. Killed P. acnes might be a powerful tool for the control of serious livestock babesiosis.
Iseki
Hiroshi
H
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Takabatake
Noriyuki
N
Ota
Naomi
N
Ishigame
Takashi
T
Yokoyama
Naoaki
N
Igarashi
Ikuo
I
D000276:Adjuvants, Immunologic / Q000502:physiology; D000818:Animals; D001403:Babesia / Q000276:immunology*; D041001:Babesia microti / Q000276:immunology; D001404:Babesiosis / Q000276:immunology / Q000517:prevention & control*; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D018664:Interleukin-12 / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D011425:Propionibacterium acnes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D015164:Vaccines, Inactivated / Q000276:immunology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D015164:Vaccines, Inactivated; D018664:Interleukin-12