title: [Radiofrequency ablation of colorectal liver metastases].
abstract: BACKGROUND
  Radiofrequency (RF) ablation is a method that uses electrical current for thermal destruction of solid tumours. We present our experience with RF ablation in a patient population with non-resectable colorectal liver metastases.
  
  
  METHODS
  17 of the 23 patients with non-resectable liver metastases treated with RF ablation at Rikshospitalet University Hospital from 2003 to 2006, were included in a prospective non-randomized study with standardized follow-up.
  
  
  RESULTS
  RF ablation was used to treat one liver metastasis in each patient, and was combined with liver resection in seven patients. The median follow-up time after RF ablation was 29 months (14-55). One-year survival was 100% and survival after both two and three years was 67%. Follow-up examinations revealed local tumour progression at the RF-treated site in eight patients, intrahepatic recurrences not related to the RF-treated site in eight patients and extrahepatic recurrence in nine patients. Four patients with intrahepatic recurrence were re-treated with a curative intent.
  
  
  CONCLUSIONS
  Long-term survival is possible after RF ablation of selected patients with non-resectable colorectal liver metastases. Local tumour progression, intrahepatic- and extrahepatic tumour recurrence is common after RF ablation. Systematic follow-up can identify tumour recurrences that may be re-treated with a curative intent. Liver resection should still be considered the gold standard for patients with resectable colorectal liver metastases.
authors.affiliation: Kirurgisk klinikk, Rikshospitalet og Intervensjonssenteret Rikshospitalet, 0027 Oslo. larsfrich@hotmail.com
authors.forename: Lars
authors.initials: L
authors.lastname: Frich
authors.forename: Knut
authors.initials: K
authors.lastname: Brabrand
authors.forename: Trond Mogens
authors.initials: TM
authors.lastname: Aaløkken
authors.forename: Bjørn
authors.initials: B
authors.lastname: Edwin
authors.forename: Ivar P
authors.initials: IP
authors.lastname: Gladhaug
mesh_terms: D000368:Aged; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies