The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats.
A preferential agonist of dopamine D3 receptors, 7-hydroxy-N-N-di-n-propyl-2-aminotetralin (7-OH-DPAT), injected into the cerebellar lobules 9 and 10 (0.001-10 microg/0.5 microl) dose-dependently reduced locomotor activity of rats. 7-OH-DPAT injections into the lobule 8 were ineffective. The 7-OH-DPAT-induced hypolocomotion was inhibited by intracerebellar (0.9 microg/0.5 microl) or systemic (0.2 mg/kg sc) injection of a selective D3 receptor antagonist, (3aR,9bS)-N-[4-(8-cyano-1,3a,4,9b-tetrahydro-3H-benzopyrano[3,4-c]pyrrole-2-yl)-butyl]-(4-phenyl) benzamide (S33084). The present results indicate that dopamine D3 receptors in lobules 9 and 10 contribute to 7-OH-DPAT-induced hypolocomotion.
Kolasiewicz
W
W
Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Maj
J
J
Ossowska
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001578:Benzopyrans / Q000494:pharmacology; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D050637:Receptors, Dopamine D3 / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D001578:Benzopyrans; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D011758:Pyrroles; D050637:Receptors, Dopamine D3; C408389:S 33084; D013764:Tetrahydronaphthalenes; C031349:7-hydroxy-2-N,N-dipropylaminotetralin