title: High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.
abstract: Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.
authors.affiliation: Unité de Pharmacochimie, School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Quai E-Ansermet 30, Geneva, Switzerland.
authors.forename: Yveline
authors.initials: Y
authors.lastname: Henchoz
authors.forename: Davy
authors.initials: D
authors.lastname: Guillarme
authors.forename: Serge
authors.initials: S
authors.lastname: Rudaz
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Veuthey
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Carrupt
mesh_terms: D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002627:Chemistry, Physical; D002853:Chromatography, Liquid / Q000379:methods; D008433:Mathematics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations