Multiple pathways for sorting mitochondrial precursor proteins.
Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal presequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the discovery of new transport pathways. Here, we review the versatility of mitochondrial protein import and its connection to mitochondrial morphology, redox regulation and energetics.
Bolender
Natalia
N
Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, Germany.
Sickmann
Albert
A
Wagner
Richard
R
Meisinger
Chris
C
Pfanner
Nikolaus
N
D000818:Animals; D006801:Humans; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D021381:Protein Transport; D020543:Proteome
D024101:Mitochondrial Proteins; D011498:Protein Precursors; D020543:Proteome