title: Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study.
abstract: Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.
authors.affiliation: Department of Clinical Neuroscience, HUBIN Project, Karolinska Institutet and Hospital, Stockholm, Sweden. erik.jonsson@ki.se
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Kristina
authors.initials: K
authors.lastname: Larsson
authors.forename: Maria
authors.initials: M
authors.lastname: Vares
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
authors.forename: August G
authors.initials: AG
authors.lastname: Wang
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
authors.forename: Kjersti S
authors.initials: KS
authors.lastname: Rønningen
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Lars
authors.initials: L
authors.lastname: Terenius
authors.forename: Håkan
authors.initials: H
authors.lastname: Hall
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D015201:Meta-Analysis as Topic; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)