[Abdominal obesity, insulin resistance, and the risk of colonic adenoma].
OBJECTIVE
Abdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis. We conducted a prospective case controlled study for the evaluation of relationship between abdominal obesity, insulin resistance, and colorectal adenoma.


METHODS
Fifty patients with colorectal adenoma and fifty healthy subjects were included in this study. Total colonoscopic examinations were performed in all the subjects. Fasting blood sugar (FBS), insulin, homeostasis model assessment (HOMA-IR), triglyceride (TG), cholesterol (CROL), BMI (body mass index), WHR (waist hip ratio), percent body fat (PBF) and obesity degree (OD) were measured. HOMA-IR was considered to represent insulin resistance. Diabetic patients were excluded from this study.


RESULTS
There were no differences in sex, serum insulin, FBS, HOMA-IR, TG, CROL between adenoma and control group. Subjects with high BMI, WHR, percent body fat, and obesity were more likely to have colonic adenoma. Multiple logistic regression analysis after adjusting confounding factors, had revealed that WHR was the most important independent risk factor for colon adenoma.


CONCLUSIONS
Abdominal obesity was most closely related to colonic adenoma. However, insulin resistance was not related to colonic adenoma. A larger case controlled study is needed.
Lee
Hang Lak
HL
Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea. alwayshang@hanyang.ac.kr
Son
Byoung Kwan
BK
Lee
Oh Young
OY
Jeon
Yong Chul
YC
Han
Dong Soo
DS
Sohn
Ju Hyun
JH
Yoon
Byung Chul
BC
Choi
Ho Soon
HS
Hahm
Joon Soo
JS
Lee
Min Ho
MH
Lee
Dong Hoo
DH
Kee
Chun Suk
CS
D050153:Abdominal Fat; D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors; D049629:Waist-Hip Ratio