title: Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.
abstract: The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.
authors.affiliation: Sección de Parasitología, Departamento de Bioquímica, Biología Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanización Montepríncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rueda
authors.forename: Soledad
authors.initials: S
authors.lastname: Fenoy
authors.forename: Fernando
authors.initials: F
authors.lastname: Simón
authors.forename: Carmen
authors.initials: C
authors.lastname: Del Aguila
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D003470:Culture Media; D010636:Phenols; C066859:2,4,6-triiodophenol