title: In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival.
abstract: Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (Matrigel, Collagen I, Purmatrix) that has the potential of providing suitable scaffolds needed to enhance stem cell survival. The longitudinal fate of transplanted stem cells was monitored by reporter imaging techniques.
authors.affiliation: Department of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford, CA, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.forename: Amir H
authors.initials: AH
authors.lastname: Sadrzadeh Rafie
authors.forename: Oscar J
authors.initials: OJ
authors.lastname: Abilez
authors.forename: Haichang
authors.initials: H
authors.lastname: Wang
authors.forename: Jennifer T
authors.initials: JT
authors.lastname: Blundo
authors.forename: Beth
authors.initials: B
authors.lastname: Pruitt
authors.forename: Christopher
authors.initials: C
authors.lastname: Zarins
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism* / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology; D002469:Cell Separation; D002470:Cell Survival / Q000187:drug effects; D008163:Luminescent Measurements; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D008856:Microscopy, Fluorescence; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D001672:Biocompatible Materials