title: Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America.
abstract: Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC 50 of 0.25 microg/ml, a MIC 90 of 0.5 microg/ml, and a range of <or=0.008 microg/ml to 1 microg/ml.
authors.affiliation: Brooke Army Medical Center, Fort Sam Houston, Texas, USA.
authors.forename: Roseanne A
authors.initials: RA
authors.lastname: Ressner
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Moore
authors.forename: James H
authors.initials: JH
authors.lastname: Jorgensen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009656:North America; D011008:Pneumococcal Infections / Q000382:microbiology; D011743:Pyrimidines / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects*
chemical_list: C587495:AR-709; D000900:Anti-Bacterial Agents; D007211:Indoles; D011743:Pyrimidines; D013762:Tetrahydrofolate Dehydrogenase