An efficient and scalable synthesis of 2,6-diaminopurine riboside.
An efficient process to synthesize 2,6-diaminopurine riboside in high yield and quality is described. This inexpensive approach was scaled up to multi-hundred kilogram quantities for use in oligonucleotide therapeutics.
Ross
Bruce S
BS
Isis Pharmaceuticals, Inc., Carlsbad, California, USA.
Springer
Robert H
RH
Ravikumar
Vasulinga T
VT
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
D009843:Oligoribonucleotides; C033854:2-aminoadenosine; D000241:Adenosine