title: Familial occurrence of spontaneous spinal CSF leaks: underlying connective tissue disorder.
abstract: Two sisters developed spontaneous cerebrospinal fluid (CSF) leaks from meningeal diverticula. Both had recurrences from non diverticular sites. Both patients, a sister, and their mother had joint hypermobility and there was a strong family history of thoracic and abdominal aorta aneurysms. To my knowledge, this is the first report of familial occurrence of CSF leaks. It also points to the role of a pre-existing dural weakness, likely related to a disorder of connective tissue matrix.
authors.affiliation: Mayo Clinic--Neurology, Rochester, MN 55905, USA.
authors.forename: Bahram
authors.initials: B
authors.lastname: Mokri
mesh_terms: D000293:Adolescent; D000328:Adult; D015170:Cerebrospinal Fluid Pressure; D003240:Connective Tissue Diseases / Q000150:complications* / Q000473:pathology; D005192:Family Health; D005260:Female; D006801:Humans; D009192:Myelography / Q000379:methods; D013353:Subdural Effusion / Q000209:etiology* / Q000473:pathology