Producing recombinant human milk proteins in the milk of livestock species.
Recombinant human proteins produced by the mammary glands of genetically modified transgenic livestock mammals represent a special aspect of milk bioactive components. For therapeutic applications, the often complex posttranslational modifications of human proteins should be recapitulated in the recombinant products. Compared to alternative production methods, mammary gland production is a viable option, underlined by a number of transgenic livestock animal models producing abundant biologically active foreign proteins in their milk. Recombinant proteins isolated from milk have reached different phases of clinical trials, with the first marketing approval for human therapeutic applications from the EMEA achieved in 2006.
Bösze
Zsuzsanna
Z
Agricultural Biotechnology Center, Gödöllõ, Hungary. bosze@abc.hu
Baranyi
Mária
M
Whitelaw
C Bruce A
CB
D000818:Animals; D000829:Animals, Domestic / Q000235:genetics* / Q000378:metabolism; D030801:Animals, Genetically Modified; D019149:Bioreactors; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008894:Milk Proteins / Q000096:biosynthesis* / Q000235:genetics; D008895:Milk, Human / Q000737:chemistry*; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics
D008894:Milk Proteins; D011994:Recombinant Proteins