title: Goserelin versus leuprolide before hysterectomy for uterine fibroids.
abstract: OBJECTIVE
  To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri.
  
  
  METHODS
  A randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose.
  
  
  RESULTS
  A total of 34 women randomized to the goserelin group and 31 women to the leuprolide group were available for analysis. Preoperative hemoglobin level (P=0.89), operative blood loss (P=0.72), and operating time (P=0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P=0.003), but blood transfusion requirement was not different between the groups (P=1.0). Other outcomes and side effects of the drugs were similar.
  
  
  CONCLUSIONS
  Goserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.
authors.affiliation: Department of Obstetrics and Gynecology, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Soo Soo
authors.initials: SS
authors.lastname: Lim
authors.forename: Jayanthi K
authors.initials: JK
authors.lastname: Sockalingam
authors.forename: Peng Chiong
authors.initials: PC
authors.lastname: Tan
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D017273:Goserelin / Q000008:administration & dosage*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000473:pathology / Q000628:therapy*; D016729:Leuprolide / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D016729:Leuprolide