An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans.
A convenient method for the synthesis of 2-bromo-3-aroyl-benzo[b]furans from readily accessible precursors has been developed. The 2-bromo group has been employed as a versatile synthetic handle in both palladium-mediated couplings and direct nucleophilic substitutions to give access to a wide range of 2-substituted-3-aroyl-benzo[b]furans.
Gill
Gurmit S
GS
Bionomics Ltd., 31 Dalgleish Street, Thebarton, South Australia 5031, Australia. bflynn@bionomics.com.au
Grobelny
Damian W
DW
Chaplin
Jason H
JH
Flynn
Bernard L
BL
D017607:Aluminum Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D001966:Bromine / Q000737:chemistry*; D015394:Molecular Structure
D017607:Aluminum Compounds; D001572:Benzofurans; D001966:Bromine