[Preparation of sinomenine microemulsion and its transdermal absorption].
OBJECTIVE
To screen the optimum formulation and prepare O/W sinomenine microemulsion and investigate its in vitro transdermal delivery ability.


METHODS
The microemulsions were prepared with the formulation containing oleic acid-tween 80-dehydrated alcohol-water by the pseudo-ternary phase diagram. The permeation flux of sinomenine was determined in vitro by Franz diffusion cell fitted with rat skin. The sinomenine was determined by HPLC. The transdermal characteristics of sinomenine microemulsion were compared with that of sinomenine gels.


RESULTS
The steady state flux of sinomenine microemulsion was significantly higher than that of sinomenine gels. The average permeation rate of sinomenine microemulsion was 116. 44 microg x cm(-2) x h(-1) in vitro.


CONCLUSIONS
These results indicated that the studied microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of sinomenine.
Zhang
Xian-Zhou
XZ
Renmin Hospital of Wuhan University, Wuhan 430060, China. rmzxz@163.com
Zhu
Hong-Da
HD
Meng
Shu-Fang
SF
Pan
Xi-Gui
XG
D000279:Administration, Cutaneous; D000818:Animals; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D008297:Male; D009019:Morphinans / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D032841:Sinomenium / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013501:Surface-Active Agents / Q000737:chemistry
D004655:Emulsions; D009019:Morphinans; D011136:Polysorbates; D013501:Surface-Active Agents; D019301:Oleic Acid; D000431:Ethanol; C009271:sinomenine