[Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin].
OBJECTIVE
To study the effect of O/W Microemulsion in enhancing solubility of baicalin and puerarin.


METHODS
The Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of baicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively.


RESULTS
11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 - 4 times than it in water.


CONCLUSIONS
Microemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.
Yang
Hua
H
Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China. yanghua2796@sina.com
Yi
Hong
H
Li
Man-Ling
ML
Cao
Zan-Ye
ZY
Feng
Wei-Hong
WH
D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions; D005419:Flavonoids / Q000032:analysis* / Q000737:chemistry; D007529:Isoflavones / Q000032:analysis* / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
D004655:Emulsions; D005419:Flavonoids; D007529:Isoflavones; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; C038044:baicalin; C033607:puerarin