title: Hybrid approach for complex coronary artery and valve disease: a clinical follow-up study.
abstract: BACKGROUND
  For patients suffering from complex coronary artery disease (CAD) with or without concomitant valve disease, no evidence is available in the current guidelines to propose a predefined treatment regimen. We sought to assess the clinical impact of an unconventional or extended definition of the hybrid approach that combines percutaneous coronary intervention (PCI) and cardiac surgery in subjects suffering from severe solitary CAD or combined with valve disease.
  
  
  RESULTS
  Between July 2002 and August 2004, 18 consecutive patients with complex CAD with or without significant valve disease who qualified for a hybrid approach were enrolled in a clinical follow-up study. Four patients eventually did not complete the proposed interventions. One patient refused treatment after inclusion, one patient died before treatment could be undertaken and two patients died after surgery but before PCI. In the other 14 cases combined treatment was technically successful. After a mean follow-up period of 15alpha5 months two patients had died, one due to sudden cardiac death and one of a noncardiac cause. No other major adverse clinical events were reported. A marked increase in quality of life was reported in those alive.
  
  
  CONCLUSIONS
  Hybrid approach had a favourable long-term outcome in patients with complex cardiovascular disease undergoing successful treatment; however, this was observed at the expense of significant periprocedural mortality in these high-risk subjects. Therefore we believe that hybrid approaches may provide an alternative for selected cases. (Neth Heart J 2007;15:329-4.).
authors.affiliation: Department of Cardiology, Medical Centre Alkmaar, Alkmaar, the Netherlands.
authors.forename: J O J
authors.initials: JO
authors.lastname: Peels
authors.forename: G A J
authors.initials: GA
authors.lastname: Jessurun
authors.forename: P W
authors.initials: PW
authors.lastname: Boonstra
authors.forename: T
authors.initials: T
authors.lastname: Ebels
authors.forename: D J
authors.initials: DJ
authors.lastname: van Veldhuisen
authors.forename: I C C
authors.initials: IC
authors.lastname: van der Horst
authors.forename: F
authors.initials: F
authors.lastname: Zijlstra