[Selenium, immunity and tumors].
The immune system has one of the essential roles in the appearance and spreading of tumors. It is also well known that the deficit of Se plays an important role in the appearance of many disease, including malignancies. As Se also has an influence on a number of immunological processes. It was interesting to estimate Se content and the function of the immune system in patients with mallignant diseases. Se content was determined in mallignant tissues as well as in the sera of mallignant patients. Immunological reactivity was measured by determination of NK cell activity of patients, or by this determination after in vitro incubation with sera with different amounts of Se. The patients were with various malignancies and the majority was with breast cancer. Se concentration in tissues and sera was in the majority of cases lower than in normal persons. The immunological reactivity measured by NK cell activity, as the most relevant test for antitumor reactivity, was evidently decreased in all the patients, corresponding to the stage of diseases. However, there was no direct correlation between Se content and NK cell activity. It is evident that a very large number of factors are included in the appearance and spreading of malignancies and that they do not have to be necessarily parallel.
Spuzić
I
I
Konjević
G
G
Djarmati
D
D
D001943:Breast Neoplasms / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D012643:Selenium / Q000032:analysis*
D012643:Selenium