[Bilateral papillary necrosis during indinavir treatment].
BACKGROUND
Papillary necrosis results from ischemia of the renal medulla and papillae, induced by a variety of mechanisms. Papillary necrosis is a rare adverse effect of continuous protease-inhibitor therapy with indinavir.


METHODS
We describe the case of a patient who developed bilateral papillary necrosis. It was reversible after treatment interruption and increased hydration.


CONCLUSIONS
This case shows the need to monitor kidney markers in patients under continuous treatment with indinavir.
Iba-Ba
Josaphat
J
Service de médecine interne A, Centre Hospitalier de Libreville, B.P. 2228, Libreville, Gabon. ibabajose@yahoo.fr
Yombi
Jean Cyr
JC
Danse
Etienne
E
Van Beers
Benoît
B
Vandercam
Bernard
B
D000328:Adult; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D008297:Male
D017320:HIV Protease Inhibitors; D019469:Indinavir