title: Hypnotic and opioid anesthetic drug interactions on the CNS, focus on response surface modeling.
abstract: This chapter will present the conceptual and applied approaches to capture the interaction of anesthetic hypnotic drugs with opioid drugs, as used in the clinical anesthetic state. The graphic and mathematical approaches used to capture hypnotic/opiate anesthetic drug interactions will be presented. This chapter is not a review article about interaction modeling, but focuses on specific drug interactions within a quite narrow field, anesthesia.
authors.affiliation: Department of Anesthesia, Insepital Bern, 3010, Bern, Switzerland. thomas.bouillon@novartis.com
authors.forename: T W
authors.initials: TW
authors.lastname: Bouillon
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D003198:Computer Simulation; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods; D004569:Electroencephalography; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008954:Models, Biological; D016343:Monitoring, Intraoperative / Q000379:methods; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement
chemical_list: D000701:Analgesics, Opioid; D000777:Anesthetics; D006993:Hypnotics and Sedatives