title: Digital-analog hybrid control model for eukaryotic heat shock response illustrating the dynamics of heat shock protein 70 on exposure to thermal stress.
abstract: We are introducing in this paper a digital-analog hybrid model approach for the study of a complete gene regulatory network; the heat shock response (HSR) network of eukaryotes. HSR is a crucial and widely studied cellular phenomenon occurring due to various stresses on the cell, and is characterised by the induction of heat shock genes resulting in the production of heat shock proteins (HSPs) which restores cellular homeostasis by maintaining protein integrity. We are proposing a model which incorporates simple digital and analog components which mimic the functioning of biological molecules involved in HSR and model their dynamics and behaviour. The simulation result of the circuit for the production of HSP70 has been found to be consistent with published experimental results. The qualitative behaviour of the HSR is expressed through a truth table. Through this novel approach, the authors have tried to develop a level of understanding of the interactions of the parts of the HSR system and of this system as a whole.
authors.affiliation: Department of Electrical and Electronics Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India. dwivedi.anjana@gmail.com
authors.forename: Anjana
authors.initials: A
authors.lastname: Dwivedi
authors.forename: Bhuwan Mohan
authors.initials: BM
authors.lastname: Karan
authors.forename: Barda Nand
authors.initials: BN
authors.lastname: Das
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sinha
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003202:Computers, Analog; D004581:Electronics; D005057:Eukaryotic Cells / Q000502:physiology*; D005246:Feedback; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted
chemical_list: D018840:HSP70 Heat-Shock Proteins