title: Evaluation of 3D modality-independent elastography for breast imaging: a simulation study.
abstract: This paper reports on the development and preliminary testing of a three-dimensional implementation of an inverse problem technique for extracting soft-tissue elasticity information via non-rigid model-based image registration. The modality-independent elastography (MIE) algorithm adjusts the elastic properties of a biomechanical model to achieve maximal similarity between images acquired under different states of static loading. A series of simulation experiments with clinical image sets of human breasts were performed to test the ability of the method to identify and characterize a radiographically occult stiff lesion. Because boundary conditions are a critical input to the algorithm, a comparison of three methods for semi-automated surface point correspondence was conducted in the context of systematic and randomized noise processes. The results illustrate that 3D MIE was able to successfully reconstruct elasticity images using data obtained from both magnetic resonance and x-ray computed tomography systems. The lesion was localized correctly in all cases and its relative elasticity found to be reasonably close to the true values (3.5% with the use of spatial priors and 11.6% without). In addition, the inaccuracies of surface registration performed with thin-plate spline interpolation did not exceed empiric thresholds of unacceptable boundary condition error.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. jao.ou@vanderbilt.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Ou
authors.forename: R E
authors.initials: RE
authors.lastname: Ong
authors.forename: T E
authors.initials: TE
authors.lastname: Yankeelov
authors.forename: M I
authors.initials: MI
authors.lastname: Miga
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D001940:Breast / Q000033:anatomy & histology* / Q000502:physiology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D003198:Computer Simulation; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods* / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D019047:Phantoms, Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000706:statistics & numerical data; D016217:Ultrasonography, Mammary / Q000379:methods / Q000706:statistics & numerical data