title: A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.
abstract: OBJECTIVE
  Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 gene and PTDM in renal allograft recipients.
  
  
  METHODS
  A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 posttransplantation diabetic patients and 450 non-posttransplantation diabetic subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR.
  
  
  RESULTS
  The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W-alleles and PTDM risk reduction (P for trend = 0.007). Patients with at least one T-allele showed a decreased risk of PTDM compared with those with the R/R genotype (R/W, risk ratio [RR] 0.78, P = 0.126; W/W, RR 0.52, P = 0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, sex, body weight gain, and type of immunosuppressant (R/W, hazard ratio [HR] 0.77, P = 0.114; W/W, HR 0.58, P = 0.026).
  
  
  CONCLUSIONS
  These data provide evidence that the SLC30A8 rs13266634 gene variation is associated with protection from the development of PTDM in renal allograft recipients.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-Gu, Seoul, Korea.
authors.forename: Eun Seok
authors.initials: ES
authors.lastname: Kang
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Yu Seun
authors.initials: YS
authors.lastname: Kim
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Han
authors.forename: Sung Wan
authors.initials: SW
authors.lastname: Chun
authors.forename: Kyu Yeon
authors.initials: KY
authors.lastname: Hur
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Soon Il
authors.initials: SI
authors.lastname: Kim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D027682:Cation Transport Proteins / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control*; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000502:physiology*; D018579:Patient Selection; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies; D040242:Risk Reduction Behavior; D014184:Transplantation, Homologous; D000075703:Zinc Transporter 8
chemical_list: D027682:Cation Transport Proteins; D007004:Hypoglycemic Agents; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8; D004247:DNA