Rotavirus-induced seizures in childhood.
Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure, encephalopathy, and death. Symptoms may vary widely, however, and children can experience short afebrile convulsions as the only manifestation of rotavirus encephalopathy. We report 4 further cases of rotavirus-induced seizures with mild neurologic manifestations. The condition is reviewed and practical management strategies are suggested.
DiFazio
Marc P
MP
Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. mddifazio@aol.com
Braun
Loranee
L
Freedman
Scott
S
Hickey
Patrick
P
D000927:Anticonvulsants / Q000627:therapeutic use; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology; D004770:Enterovirus / Q000302:isolation & purification; D005243:Feces / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D010672:Phenytoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D012640:Seizures / Q000188:drug therapy / Q000821:virology*; D012720:Severity of Illness Index; D014839:Vomiting / Q000821:virology
D000927:Anticonvulsants; D010672:Phenytoin; C043114:fosphenytoin; D008140:Lorazepam