title: Gp96 and its different expression in breast carcinomas.
abstract: The aim of our work was to determine the expression of glycoprotein 96 (gp96; glucose-regulated protein 94 - GRP94) in 69 samples of breast carcinoma. Enzyme immunohistochemical method was chosen for the detection of gp96 protein and its expression was compared in breast cancer cells versus normal breast cells. We found higher expression of gp96 protein in breast carcinoma cells and low or no expression in normal breast cells. Furthermore, we demonstrate first time, that ductal invasive breast carcinomas showed higher expression of gp96 than lobular invasive breast carcinomas.
authors.affiliation: Department of Anatomy, P.J. Safarik University, Faculty of Medicine, Kosice, Slovak Republic. ingrid.hodorova@post.sk
authors.forename: I
authors.initials: I
authors.lastname: Hodorova
authors.forename: S
authors.initials: S
authors.lastname: Rybarova
authors.forename: P
authors.initials: P
authors.lastname: Solar
authors.forename: J
authors.initials: J
authors.lastname: Vecanova
authors.forename: L
authors.initials: L
authors.lastname: Prokopcakova
authors.forename: P
authors.initials: P
authors.lastname: Bohus
authors.forename: Z
authors.initials: Z
authors.lastname: Solarova
authors.forename: Y
authors.initials: Y
authors.lastname: Mellova
authors.forename: K
authors.initials: K
authors.lastname: Schmidtova
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism*; D018275:Carcinoma, Lobular / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C052646:sarcoma glycoprotein gp96 rejection antigens