title: BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts.
abstract: The influence of conditioning regimen, donor background and HLA matching on development of BK virus (BKV)-associated haemorrhagic cystitis (HC) was examined in 175 allogeneic haematopoietic stem cell transplant (HSCT) patients, undergoing 179 HSCT events. Twenty-seven patients presented late-onset HC, and BK viruria was verified in 23/27 HC events. Seventy-one (40%) HSCTs were performed with myeloablative conditioning (MC), 108 (60%) were performed with reduced intensity conditioning (RIC), 66 (37%) were performed with a related donor (RD) grafts and 113 (63%) with an unrelated donor (URD) graft. BK viruria was more common during HC, than non-HC events, after MC as compared to RIC (both P<0.001), and with an HLA-mismatched donor (P<0.01). By multivariate logistical regression analysis, independent risk factors for HC were BKV (OR 6.7; 95% CI 2.0-21.7; P=0.001), MC (OR 6.0; 95% CI 2.1-17.3; P<0.001) and URD (OR 3.4; 95% CI 1.1-10.6; P=0.03). However, when analysing HSCT performed with URD or RD grafts separately, BKV (OR 8.5; 95% CI 1.8-19.3; P=0.004) and MC (OR 5.9; 95% CI 1.3-11.3; P=0.009) increased the risk for HC only with a URD, but not with an RD graft.
authors.affiliation: Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Giraud
authors.forename: P
authors.initials: P
authors.lastname: Priftakis
authors.forename: G
authors.initials: G
authors.lastname: Bogdanovic
authors.forename: M
authors.initials: M
authors.lastname: Remberger
authors.forename: M
authors.initials: M
authors.lastname: Dubrulle
authors.forename: A
authors.initials: A
authors.lastname: Hau
authors.forename: R
authors.initials: R
authors.lastname: Gutmark
authors.forename: J
authors.initials: J
authors.lastname: Mattson
authors.forename: B-M
authors.initials: BM
authors.lastname: Svahn
authors.forename: O
authors.initials: O
authors.lastname: Ringden
authors.forename: J
authors.initials: J
authors.lastname: Winiarski
authors.forename: P
authors.initials: P
authors.lastname: Ljungman
authors.forename: T
authors.initials: T
authors.lastname: Dalianis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001739:BK Virus / Q000472:pathogenicity; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000503:physiopathology / Q000821:virology*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D027601:Polyomavirus Infections / Q000503:physiopathology / Q000652:urine; D012189:Retrospective Studies; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000009:adverse effects* / Q000379:methods; D014412:Tumor Virus Infections / Q000503:physiopathology / Q000652:urine