title: The effect of the type of intraperitoneally implanted prosthetic mesh on the systemic inflammatory response.
abstract: BACKGROUND
  The purpose of this study was to determine any differences in the systemic inflammatory response after the intraperitoneal implantation of three different types of polypropylene mesh.
  
  
  METHODS
  Thirty-two male New Zealand rabbits underwent a 6-cm midline incision and opening of the peritoneal cavity. The animals were randomly divided into four groups. In groups A, B, and C, there was an intraperitoneal placement of polypropylene mesh, titanium-coated polypropylene mesh, and composite polypropylene/e-PTFE mesh, respectively. Group D received a sham operation. Blood was sampled preoperatively and at 6, 24, 48, and 168 h postoperatively to measure white blood cell count (WBC), tumor necrosis factor-alpha (TNF-alpha), and malondialdehyde (MDA).
  
  
  RESULTS
  Statistically significant elevations of WBC, TNF-alpha and MDA were observed in all four groups at 6, 24, and 48 h postoperatively (P<0.05). There were no statistically significant differences in WBC, TNF-alpha, and MDA between groups A, B, and C at any time interval. However, a statistically significant elevation of WBC (P<0.05) and TNF-alpha (P<0.05) was observed between each of the groups with mesh implantation and group D at 24 h postoperatively.
  
  
  CONCLUSIONS
  Intraperitoneal mesh implantation induces mild systemic inflammatory response regardless of the type of implanted mesh.
authors.affiliation: 2nd Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. gchatzimav@yahoo.gr
authors.forename: G
authors.initials: G
authors.lastname: Chatzimavroudis
authors.forename: I
authors.initials: I
authors.lastname: Koutelidakis
authors.forename: B
authors.initials: B
authors.lastname: Papaziogas
authors.forename: T
authors.initials: T
authors.lastname: Tsaganos
authors.forename: P
authors.initials: P
authors.lastname: Koutoukas
authors.forename: E
authors.initials: E
authors.lastname: Giamarellos-Bourboulis
authors.forename: S
authors.initials: S
authors.lastname: Atmatzidis
authors.forename: K
authors.initials: K
authors.lastname: Atmatzidis
mesh_terms: D000818:Animals; D059685:Herniorrhaphy; D007958:Leukocyte Count; D008315:Malondialdehyde / Q000097:blood; D010537:Peritoneum / Q000601:surgery; D011126:Polypropylenes; D011817:Rabbits; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013526:Surgical Mesh / Q000009:adverse effects*; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D011126:Polypropylenes; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde