title: Comparison of histidine-tryptophan-ketoglutarate and University of Wisconsin preservation in renal transplantation.
abstract: Histidine-tryptophan-ketoglutarate (HTK) is replacing University of Wisconsin (UW) solution as the preservation fluid for renal allografts in many centers, but recent large-scale data to support this transition are lacking. We conducted a retrospective analysis of patient and graft outcomes after renal transplantation at our center, comparing 475 consecutive living donor and 317 deceased donor transplants since the adoption of HTK with equal numbers of grafts preserved using UW solution. Data collected included donor and recipient age, race, sex, comorbidities and graft ischemia time. Graft and patient survival, as well as the incidence of delayed graft function (DGF), were studied by Kaplan-Meier and Cox regression analysis. No significant difference was seen in either patient or graft survival. Deceased donor kidneys in the HTK group had a higher incidence of DGF than the UW cohort, whereas this trend was reversed in the case of living donor organs. In multivariate analysis, HTK was associated with a significant risk reduction on the incidence of DGF. Prolonged preservation with HTK compared to UW was not associated with excess risk to the graft or patient. In summary, HTK demonstrated efficacy similar to UW in terms of patient and graft survival.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Michigan, Ann Arbor, MI, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Lynch
authors.forename: J
authors.initials: J
authors.lastname: Kubus
authors.forename: R H
authors.initials: RH
authors.lastname: Chenault
authors.forename: S J
authors.initials: SJ
authors.lastname: Pelletier
authors.forename: D A
authors.initials: DA
authors.lastname: Campbell
authors.forename: M J
authors.initials: MJ
authors.lastname: Englesbe
mesh_terms: D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D051799:Delayed Graft Function / Q000453:epidemiology; D005260:Female; D005947:Glucose; D005978:Glutathione; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007328:Insulin; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011189:Potassium Chloride; D011343:Procaine; D011887:Raffinose; D012189:Retrospective Studies
chemical_list: C039984:Bretschneider cardioplegic solution; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D011343:Procaine; D000493:Allopurinol; D011189:Potassium Chloride; D005978:Glutathione; D005947:Glucose; D000241:Adenosine; D011887:Raffinose