title: A propos time and autoimmunity.
abstract: The integrated defense system has been shaped over eons showing noteworthy robustness by surviving a million-year prehistory, a comparatively short evolving history and current transformation. Self-identification being part of it, so are deviations manifold expressed in autoimmunity. Epidemiological incidence and intensity, both being subject of change, are focused in the light of the time factor. Furthermore, it is stressed that there is no bi-univocal mutual relationship between immunity and defense and the origins of autoimmunity still remain mysterious. We question whether the present transforming events have occurred within too short a time to be attributed to genetic predisposition exclusively.
authors.affiliation: Facultad de Ingenieria, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina.
authors.forename: Pablo I
authors.initials: PI
authors.lastname: Martín
authors.forename: Ana I
authors.initials: AI
authors.lastname: Malizia
authors.forename: E
authors.initials: E
authors.lastname: Rewald
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D001419:Bacteria / Q000276:immunology; D005075:Biological Evolution; D020022:Genetic Predisposition to Disease; D006801:Humans; D013997:Time Factors