title: Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis.
abstract: Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness.
authors.affiliation: University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Roiz-Santiáñez
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
authors.forename: Rocío
authors.initials: R
authors.lastname: Pérez-Iglesias
authors.forename: José María
authors.initials: JM
authors.lastname: Pelayo-Terán
authors.forename: Eugenio
authors.initials: E
authors.lastname: Carrasco-Marín
authors.forename: Ignacio
authors.initials: I
authors.lastname: Mata
authors.forename: Elena
authors.initials: E
authors.lastname: Sánchez
authors.forename: Francisco
authors.initials: F
authors.lastname: Leyva-Cobián
authors.forename: José Luis
authors.initials: JL
authors.lastname: Vázquez-Barquero
mesh_terms: D000483:Alleles; D020029:Base Pairing; D001921:Brain / Q000473:pathology*; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009778:Occipital Lobe / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein