title: Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome.
abstract: OBJECTIVE
  The changing pattern of acute poisoning may affect complications and outcome in these patients. An update study on acute poisonings was therefore performed and compared to similar data from 1980.
  
  
  METHODS
  A prospective cross-sectional multi-center study of all adult patients (> or = 16 years) hospitalized in Oslo with a main diagnosis of acute poisoning, irrespective of intention, over a one-year period.
  
  
  RESULTS
  Of 947 admissions, 222 (23%) were comatose. Complications were observed in 173 (18%), slightly reduced from 1980 (22%). Ten (1.1%) died and six (0.6%) got permanent sequelae, of which seven and five were drug- or alcohol-related, respectively. Seventy-five percent received treatment besides observation; 39% received antidotes, increased from 21% in 1980, most frequently flumazenil (23%) and naloxone (14%).
  
  
  CONCLUSIONS
  In-hospital mortality in poisoned patients remained low, few patients entailed complications, and most patients survived without permanent sequelae. Drug- and alcohol-abuse related poisonings were most severe.
authors.affiliation: Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway. fridtjof.heyerdahl@medisin.uio.no
authors.forename: Fridtjof
authors.initials: F
authors.lastname: Heyerdahl
authors.forename: Mari A
authors.initials: MA
authors.lastname: Bjornas
authors.forename: Knut Erik
authors.initials: KE
authors.lastname: Hovda
authors.forename: Karina
authors.initials: K
authors.lastname: Skog
authors.forename: Anders
authors.initials: A
authors.lastname: Opdahl
authors.forename: Cecilie
authors.initials: C
authors.lastname: Wium
authors.forename: Oivind
authors.initials: O
authors.lastname: Ekeberg
authors.forename: Dag
authors.initials: D
authors.lastname: Jacobsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000931:Antidotes / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced; D003430:Cross-Sectional Studies; D000431:Ethanol / Q000506:poisoning*; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use; D017052:Hospital Mortality / Q000639:trends*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000627:therapeutic use; D009664:Norway; D011041:Poisoning / Q000453:epidemiology / Q000628:therapy*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D013287:Illicit Drugs; D009270:Naloxone; D000431:Ethanol; D005442:Flumazenil