[Erythrocytic membrane status (as cell model) in cases of severe cranium-face trauma: possibilities for correction].
Acute posttraumatic period of severe maxillofacial trauma in case of hyperbaric oxygenation therapy is followed by expressed activation of lipide-peroxide-oxidation (LPO) in erythrocytic membrane on the background of significant reduction of the substrate for fermentative antioxidation system (AOS). Imbalance in the system LPO:AOS is followed by expressed structural reorganization in erythrocytic membrane and build-up extraerythrocytic haemoglobin in plasma. Klonidine promotes LPO activity reduction and prevents depletion of AOS fermentative capacity in membrane that is followed by normalization of structural-functional interrelations in membrane and reduction of the level of extraerythrocytic haemoglobin in plasma.
Karmen
N B
NB
Miliutina
N P
NP
Zakarov
A M
AM
Maevskĭ
E I
EI
Ippolitov
V P
VP
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D002374:Catalase / Q000032:analysis; D003000:Clonidine / Q000627:therapeutic use*; D006259:Craniocerebral Trauma / Q000175:diagnosis* / Q000188:drug therapy*; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D013482:Superoxide Dismutase / Q000032:analysis; D014783:Viscosity
D000316:Adrenergic alpha-Agonists; D006454:Hemoglobins; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D003000:Clonidine