title: Therapeutic experience of Bing-Neel Syndrome associated with Waldenstrom's macroglobulinemia.
abstract: Waldenstrom's macroglobulinemia is an uncommon low-grade B-cell lymphoproliferative disorder in which monoclonal immunoglobulin M is produced. Neurological symptoms due to hyperviscosity are frequent manifestations of Waldenstrom's macroglobulinemia. However, central nervous system infiltration by plasmacytoid lymphocytes (Bing-Neel syndrome) has only rarely been reported. We report a case of a 51-yr-old woman suffering from Waldenstrom's macroglobulinemia who complained of persistant headache. Brain magnetic resonance imaging revealed an extra-axial soft tissue mass along the left cavernous sinus, left tentorium, right tentorium, and falx cerebri. A stereotactic biopsy of dural tissue from the falx was performed and showed plasmacytoid lymphocyte infiltration. The patient became symptom- free with irradiation of the whole brain followed by chemotherapy with fludarabine.
authors.affiliation: Department of Internal Medicine, Yeoungnam University College of Medicine, Daegu, Korea.
authors.forename: Hyun Do
authors.initials: HD
authors.lastname: Kim
authors.forename: Kyeong Cheol
authors.initials: KC
authors.lastname: Shin
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Cho
authors.forename: Min Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000209:etiology / Q000628:therapy*; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D000069283:Rituximab; D013577:Syndrome; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014740:Vidarabine; C024352:fludarabine