title: The J-Tip Needle-Free Injection System in controlled ovarian hyperstimulation in in vitro fertilization: a pilot study.
abstract: OBJECTIVE
  To evaluate the use of a novel needle-free system (J-Tip) in the administration of gonadotropins for controlled ovarian hyperstimulation (COH) in IVF.
  
  
  METHODS
  An open-label, single-center, pilot study.
  
  
  METHODS
  Assisted conception unit of a university hospital.
  
  
  METHODS
  Twenty patients undergoing COH over a 3-month period.
  
  
  METHODS
  COH was carried out using a fixed dose of rFSH administered via the J-Tip System in a GnRH antagonist cycle.
  
  
  METHODS
  The primary endpoint was the mean number of oocytes collected per patient, and secondary endpoints were incidence of technically correct injections, clinical pregnancy, and cancellation rates. Patient diaries were kept throughout the study.
  
  
  RESULTS
  Sixteen patients completed the trial, four of whom became pregnant, with a high overall satisfaction rate.
  
  
  CONCLUSIONS
  This is the first report of the use of the novel J-Tip Needle-Free Injection System for administration of gonadotropins in IVF with successful ovarian stimulation and achievement of pregnancies. This report indicates that this technique is associated with minimal pain and high patient acceptability. Large-scale multicenter studies are required to examine the reproducibility of these results and the J-Tip's cost-effectiveness as well as to compare the J-tip System with conventional needle-wise administration for COH before its introduction into routine IVF practice.
authors.affiliation: Department of Reproductive Medicine and Surgery, Assisted Conception Unit, Hammersmith Hospital, Imperial College School of Medicine, London, United Kingdom.
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Lavery
authors.forename: Salem A
authors.initials: SA
authors.lastname: El-Shawarby
authors.forename: Cathy
authors.initials: C
authors.lastname: Turner
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Trew
mesh_terms: D000328:Adult; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004624:Embryo Transfer; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007246:Infertility / Q000378:metabolism / Q000628:therapy*; D007267:Injections; D054315:Oocyte Retrieval; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D010062:Ovulation Induction / Q000009:adverse effects / Q000295:instrumentation*; D017060:Patient Satisfaction; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D006727:Hormone Antagonists; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone