title: [Preparation of sinomenine microemulsion and its transdermal absorption].
abstract: OBJECTIVE
  To screen the optimum formulation and prepare O/W sinomenine microemulsion and investigate its in vitro transdermal delivery ability.
  
  
  METHODS
  The microemulsions were prepared with the formulation containing oleic acid-tween 80-dehydrated alcohol-water by the pseudo-ternary phase diagram. The permeation flux of sinomenine was determined in vitro by Franz diffusion cell fitted with rat skin. The sinomenine was determined by HPLC. The transdermal characteristics of sinomenine microemulsion were compared with that of sinomenine gels.
  
  
  RESULTS
  The steady state flux of sinomenine microemulsion was significantly higher than that of sinomenine gels. The average permeation rate of sinomenine microemulsion was 116. 44 microg x cm(-2) x h(-1) in vitro.
  
  
  CONCLUSIONS
  These results indicated that the studied microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of sinomenine.
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan 430060, China. rmzxz@163.com
authors.forename: Xian-Zhou
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Hong-Da
authors.initials: HD
authors.lastname: Zhu
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Meng
authors.forename: Xi-Gui
authors.initials: XG
authors.lastname: Pan
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D008297:Male; D009019:Morphinans / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D032841:Sinomenium / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004655:Emulsions; D009019:Morphinans; D011136:Polysorbates; D013501:Surface-Active Agents; D019301:Oleic Acid; D000431:Ethanol; C009271:sinomenine