Disseminated herpes simplex type-2 (HSV-2) infection after solid-organ transplantation.
We report on three cases of severe disseminated Herpes simplex type-2 (HSV-2) infection that occurred in two orthotopic liver-transplant (OLT) and one renal-transplant patients. In two cases, i.e., in the OLT patients, this was associated with HSV-2-related acute hepatitis. The rapid onset of IV acyclovir (ACV) therapy led to recovery within 8-12 days. Although rare, HSV-2-disseminated infection, in the context of organ transplantation may be life-threatening, but can be cured if ACV therapy is initiated early in the course of this disease.
Basse
G
G
Department of Nephrology, Dialysis, and Multi-organ Transplantation, CHU, Rangueil, University Hospital, 1 av. Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
Mengelle
C
C
Kamar
N
N
Ribes
D
D
Selves
J
J
Cointault
O
O
Suc
B
B
Rostaing
L
L
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D018258:Herpesvirus 2, Human; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology / Q000821:virology*
D000998:Antiviral Agents; D000212:Acyclovir