title: [Cancer chemotherapy of the upper aerodigestive tract].
abstract: Tumours of the upper aerodigestive tract represent the sixth most frequent kind of cancer in France and throughout the world. If the localised forms may be controlled in the long run in two thirds of cases by surgery or radiotherapy, only one third of locally advanced forms are accessible to a cure after association from radiotherapy and chemotherapy. Besides, with a median of survival less than six months, metastatic tumours present a catastrophic spontaneous prognosis among patients with a medical ground that is often heavily deteriorated by prolonged exposure to alcohol and tobacco. Thus, there is a necessity to implement adapted therapeutic strategies to each patient and based on satisfactory proof levels of effectiveness. Optimisation of existing chemotherapy protocols and development of new therapies, in particular of targeted therapies, remain an important objective in the hope to improve results of treatments in locally advanced and metastatic cancers of the oral cavity.
authors.affiliation: Service d'oncologie et radiothérapie, hôpital d'instruction des Armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Védrine
authors.forename: C
authors.initials: C
authors.lastname: Chargari
authors.forename: S
authors.initials: S
authors.lastname: Le Moulec
authors.forename: M
authors.initials: M
authors.lastname: Fayolle
authors.forename: B
authors.initials: B
authors.lastname: Ceccaldi
authors.forename: O
authors.initials: O
authors.lastname: Bauduceau
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents