[Branched antimicrobial peptides].
Branched peptides E(RLAR)2, E[E(RLAR)2]2, E(KLAR)2, and E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 microM for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.
Khrushchev
A Iu
AIu
Kashparov
I A
IA
Klimenko
L V
LV
Mitin
Iu V
IuV
D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D005971:Glutamates / Q000737:chemistry; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry*; D005466:Fluorocarbons
D023181:Antimicrobial Cationic Peptides; D005971:Glutamates; D009842:Oligopeptides; C526700:arginyl-leucyl-alanyl-arginine; C526702:glutamic acid bis(pentafluorophenyl)ester; D005466:Fluorocarbons; C526701:lysyl-leucyl-alanyl-arginine