title: Aplaminal: a novel cytotoxic aminal isolated from the sea hare Aplysia kurodai.
abstract: Aplaminal (1), a novel triazabicyclo[3.2.1]octane framework metabolite, has been isolated from the sea hare Aplysia kurodai. The structure was determined by analysis of NMR data and confirmed by single-crystal X-ray diffraction analysis. Aplaminal (1) exhibits cytotoxicity against Hela S3 cells.
authors.affiliation: Department of Chemistry, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuroda
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001048:Aplysia / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D053961:Azabicyclo Compounds; C527920:aplaminal; D005492:Folic Acid