[Experimental study on relationship between TCM syndrome type and gastric mucosa cell proliferation in rat model of chronic atrophic gastritis].
OBJECTIVE
To explore the relationship between TCM syndrome type and gastric mucosa cell proliferation related controlling gene protein in chronic atrophic gastritis (CAG).


METHODS
Expressions of cell proliferation related controlling gene protein, including proliferative cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR) and c-myc, from gastric mucosa of CAG model rats with different syndrome types were measured by immunohistochemistry and the changes of them before and after TCM intervention were also analyzed by image analysis.


RESULTS
Protein expressions of PCNA, EGFR and c-myc in gastric mucosa of CAG model rats with different syndrome types (Pi-deficiency type, Gan-stagnation type and dampness-heat type) were different to some extent, and all of them reduced significantly after TCM intervention in the model rats of all syndrome types.


CONCLUSIONS
Expressions of cell proliferation related controlling gene protein in gastric mucosa of CAG model rats of different syndrome types were different to some extent, which provides a certain experimental evidence for revealing the essence of TCM syndrome type of CAG and judging the prognosis of various types.
Xu
Shan
S
Zhejiang University of TCM, Hangzhou. xushanhz@163.com
Wang
Chang-song
CS
Zhou
Jia-he
JH
D000818:Animals; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D066246:ErbB Receptors / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005757:Gastritis, Atrophic / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013577:Syndrome
D004365:Drugs, Chinese Herbal; D018809:Proliferating Cell Nuclear Antigen; D016271:Proto-Oncogene Proteins c-myc; C483803:Egfr protein, rat; D066246:ErbB Receptors