[Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats].
OBJECTIVE
To determine the changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats of chronic epilepsy induced by pentylenetetrazole (PTZ).


METHODS
Sixty rats were randomly divided into a control group and a PTZ group (PTZ 30 mg/kg, intraperitoneal injection, once daily). The changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats were examined by Timm staining.


RESULTS
Before the occurrence of convulsion confirmed by behavior and EEG, the mossy fiber sprouting was found in the PTZ group. The grade of the mossy fiber sprouting increased with the gradual establishment of kindling effect.


CONCLUSIONS
Mossy fiber sprouting may play an important role in the onset and development of epilepsy.
Tian
Fa-fa
FF
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. tianff@sina.com
Guo
Ting-hui
TH
Chen
Jin-mei
JM
Ma
Yun-feng
YF
Cai
Xiao-feng
XF
Yao
Feng-hong
FH
D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D019599:Mossy Fibers, Hippocampal / Q000254:growth & development*; D009474:Neurons / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010433:Pentylenetetrazole