JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?
The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.
Smirnova
Olga V
OV
Laboratory of Endocrinology, Biological Faculty, M.V. Lomonosov Moscow State University, Leninskie Gory, 1/12, 119992, Moscow, Russia. smirnova_ov@mail.ru
Ostroukhova
Tatiana Yu
TY
Bogorad
Roman L
RL
D001650:Bile Duct Neoplasms / Q000503:physiopathology*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000503:physiopathology*; D006801:Humans; D053612:Janus Kinases / Q000502:physiology*; D050791:STAT Transcription Factors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D050791:STAT Transcription Factors; D053612:Janus Kinases