Synthesis and characterization of the 5-methyl-2'-deoxycytidine glycol-dioxoosmium-bipyridine ternary complex in DNA.
It has been established that approximately 80% of a 5-methyl-2'-deoxycytidine glycol-dioxoosmium(vi)-bipyridine ternary complex, which is known to be produced as one of various consequences of oxidative damage of DNA and is formed in a key step of a recently developed DNA methylation detection method, has the 5R,6S configuration.
Umemoto
Tadashi
T
Frontier Research System, RIKEN, Wako, Saitama 351-0198, Japan.
Okamoto
Akimitsu
A
D018360:Crystallography, X-Ray; D003562:Cytidine / Q000031:analogs & derivatives* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013997:Time Factors
C527566:5-methyl-2'-deoxycytidine glycol-dioxoosmium-bipyridine; D009942:Organometallic Compounds; D011725:Pyridines; D009992:Osmium; D003562:Cytidine; D004247:DNA; C023666:pyridine