Preventive effects of ACTICOA powder, a cocoa polyphenolic extract, on experimentally induced prostate hyperplasia in Wistar-Unilever rats.
Plant extracts are useful in the management of benign prostatic hyperplasia (BPH). This study investigates whether ACTICOA (Barry Callebaut France, Louviers, France) powder (AP), a cocoa polyphenolic extract, could prevent prostate hyperplasia induced by testosterone propionate (TP) in rats. Male Wistar-Unilever rats were randomly divided in four groups of 12 rats: one negative control group receiving subcutaneous injections of corn oil and treated with vehicle and three groups injected subcutaneously with TP and treated with the vehicle (positive control) or AP at 24 (AP24) and 48 (AP48) mg/kg/day. Treatments were given orally and started 2 weeks before the induction of prostate hyperplasia. The influence of TP and AP on body weights and food and water consumption of rats was examined. On day 36, rats were sacrificed, and the prostates were removed, cleaned, and weighed. The prostate size ratio (prostate weight/rat body weight) was then calculated. TP significantly influenced the body weight gain of the rats and their food and water consumption, while AP at both doses tested reduced significantly these differences. TP significantly increased prostate size ratio (P < .001), and this induced increase was significantly inhibited in AP-treated rats in comparison with positive controls (P < .001) in a dose-dependent manner. We conclude that AP can prevent TP-induced prostate hyperplasia and therefore may be beneficial in the management of BPH.
Bisson
Jean-François
JF
ETAP - Ethologie Appliquée, Centre de Recherche en Pharmacologie, Cancérologie & Pathologies Humaines et Nutrition-Santé, Vandoeuvre-lès-Nancy, France. jfbisson@etap-lab.com
Hidalgo
Sophie
S
Rozan
Pascale
P
Messaoudi
Michaël
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002099:Cacao / Q000737:chemistry*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols; D011208:Powders; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D043343:Testosterone Propionate / Q000008:administration & dosage
D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D011208:Powders; D043343:Testosterone Propionate