title: Strategic approaches to developing drug treatments for ALS.
abstract: Significant progress in understanding the cellular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) has not been matched with the development of therapeutic strategies to prevent disease progression. The multiple potential causes and relative rarity of the disease are two significant factors that make drug development and assessment in clinical trials extremely difficult. We review recent progress in promoting therapeutics into clinical trials and highlight the value of moderate throughput screening for the acceleration and improvement of drug design.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor 48109, United States. andreav@med.umich.edu
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Vincent
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Sakowski
authors.forename: Adam
authors.initials: A
authors.lastname: Schuyler
authors.forename: Eva L
authors.initials: EL
authors.lastname: Feldman
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D000818:Animals; D003198:Computer Simulation; D004195:Disease Models, Animal; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use
chemical_list: D018696:Neuroprotective Agents; D007334:Insulin-Like Growth Factor I