Auer rod-like intracytoplasmic inclusions in multiple myeloma. A case report and review of the literature.
Several intracytoplasmic morphological changes in the plasma cells of multiple myeloma have been described previously. However, Auer rod-like inclusions are rarely found in these types of cells. Here, we report a case of multiple myeloma with Auer rod-like, needle-shaped intracytoplasmic inclusions in plasma cells. A review of all published cases revealed that this phenomenon is exclusively found in myeloma with kappa-type paraprotein. The nature of these intracellular inclusions and the relationship to prognostic implications and concomitant illnesses are discussed.
Hütter
G
G
Medizinische Klinik III, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. gero.huetter@charite.de
Nowak
D
D
Blau
I W
IW
Thiel
E
E
D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis
D018906:Antineoplastic Agents, Alkylating; D005938:Glucocorticoids; D011239:Prednisolone; D008558:Melphalan