The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test.
Increased impulsivity is observed across a number of neuropsychiatric and neurodegenerative diseases. Preclinical evidence has demonstrated that antagonism of the serotonin 5-HT(2C) receptor may act to increase impulsivity, leading to the hypothesis that an agonist may exert reciprocal effects and attenuate impulsive behavior. The 5-HT(2C) agonist, WAY-163909, was evaluated in the present paper using a variable stimulus duration and inter-trial interval manipulation in the 5-choice serial reaction time test designed to increase impulsivity and decrease attention. WAY-163909 treatment selectively and dose-dependently decreased impulsivity suggesting that agonism of the 5-HT(2C) receptor may be useful for modulating impulsivity in disease states where impulsivity is a pathological feature.
Navarra
Rachel
R
Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA.
Comery
Thomas A
TA
Graf
Radka
R
Rosenzweig-Lipson
Sharon
S
Day
Mark
M
D000818:Animals; D001381:Azepines / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007175:Impulsive Behavior / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000187:drug effects*; D058826:Serotonin 5-HT2 Receptor Agonists
C501656:1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole; D001381:Azepines; D007211:Indoles; D058826:Serotonin 5-HT2 Receptor Agonists