title: Brain cell membrane motion-restricted phospholipids in patients with schizophrenia who have seriously and dangerously violently offended.
abstract: This study directly assessed, for the first time, whether there was a change in brain cell motion-restricted membrane phospholipids in vivo in male forensic patients with schizophrenia who had seriously and violently offended (homicide, attempted murder, or wounding with intent to cause grievous bodily harm) while psychotic, by quantification of the broadband resonance signal from 31-phosphorus neurospectroscopy scans. Cerebral 31-phosphorus magnetic resonance spectroscopy was carried out in 15 such patients, who suffered from positive symptoms of schizophrenia, and in 12 age- and sex-matched normal control subjects. Spectra were obtained from 70 x 70 x 70 mm(3) voxels using an image-selected in vivo spectroscopy pulse sequence. There was no significant difference in the broad resonances between the two groups, with the mean (standard error) percentage broadband signal for the patients being 57.8 (5.6) and that for the control subjects 57.7 (6.0). The phosphomonoesters and phosphodiesters narrow signals also did not differ between the groups. These results suggest that patients with schizophrenia who have predominantly positive symptoms may not show neuroimaging-based signs compatible with the membrane phospholipid hypothesis of schizophrenia.
authors.affiliation: MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England, W12 0HS, UK. basant.puri@csc.mrc.ac.uk
authors.forename: Basant K
authors.initials: BK
authors.lastname: Puri
authors.forename: Serena J
authors.initials: SJ
authors.lastname: Counsell
authors.forename: Gavin
authors.initials: G
authors.lastname: Hamilton
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: Bustos
authors.forename: Ian H
authors.initials: IH
authors.lastname: Treasaden
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D002462:Cell Membrane / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D010759:Phosphorus Isotopes; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D014754:Violence / Q000523:psychology*
chemical_list: D010743:Phospholipids; D010759:Phosphorus Isotopes