Innate and adaptive mechanisms to control [corrected] pathological intestinal inflammation.
The intestine is the home of a tremendous number of commensal organisms that have a primary role in host metabolism. As a consequence, the gut mucosa has evolved multiple layers of protection. This review highlights both innate and adaptive mechanisms that prevent bacterial invasion and abnormal intestinal inflamamation, how a failure of these mechanisms may be involved in the pathogenesis of inflammatory bowel diseases, and discusses new findings implicating dendritic cells as central to the induction of active mucosal tolerance to commensal bacteria.
Kelsall
B L
BL
Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1886, USA. kelsall@nih.gov
D001419:Bacteria / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000276:immunology / Q000503:physiopathology; D007422:Intestines / Q000276:immunology; D013559:Symbiosis / Q000276:immunology