Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele.
To investigate the influence of glutathione S-transferase T1 (GSTT1) gene polymorphism on Chinese infertile patients with varicocele, 63 infertile patients with varicocele and 54 healthy fertile controls were recruited in this case-control study. Our results show that oxidative damage may be the cause of infertility in patients with varicocele, and GSTT1 null genotype predisposes to over oxidative damage to spermatocytes of infertile patients with varicocele.
Wu
Qifei
Q
Department of Urology, First Affiliated Hospital, School of Medicine, Xi'an Jiao Tong University, Xi'an City, ShannXi Province, People's Republic of China.
Xing
Junping
J
Xue
Wei
W
Sun
Jianhua
J
Wang
Xinyang
X
Jin
Xiaojuan
X
D000975:Antioxidants / Q000032:analysis; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000032:analysis; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009569:Nitric Oxide / Q000032:analysis; D016017:Odds Ratio; D018384:Oxidative Stress / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012661:Semen / Q000737:chemistry; D014646:Varicocele / Q000150:complications / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*
D000975:Antioxidants; D015415:Biomarkers; D004272:DNA, Mitochondrial; D009569:Nitric Oxide; D008315:Malondialdehyde; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase