title: Reversible posterior leukoencephalopathy syndrome in 2 HIV-infected patients receiving antiretroviral therapy.
abstract: We describe 2 human immunodeficiency virus-infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syndrome with hypertension and endothelial damage. We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome.
authors.affiliation: Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy.
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Ridolfo
authors.forename: Federico
authors.initials: F
authors.lastname: Resta
authors.forename: Laura
authors.initials: L
authors.lastname: Milazzo
authors.forename: Ilaria
authors.initials: I
authors.lastname: Caramma
authors.forename: Giovanni
authors.initials: G
authors.lastname: Matacena
authors.forename: Spinello
authors.initials: S
authors.lastname: Antinori
authors.forename: Massimo
authors.initials: M
authors.lastname: Galli
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000821:virology; D008297:Male; D008875:Middle Aged; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000821:virology*
chemical_list: D044966:Anti-Retroviral Agents