title: Trichodermatides A-D, novel polyketides from the marine-derived fungus Trichoderma reesei.
abstract: Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Ma
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zheng
authors.forename: A-Li
authors.initials: AL
authors.lastname: Lv
authors.forename: Ken
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C527910:trichodermatide A