Effects of subdural application of lidocaine in patients with focal epilepsy.
Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.
Madhavan
Deepak
D
New York University Comprehensive Epilepsy Center, 403 East 34th Street, 4th Floor, New York, NY 10016, United States. dpak01@yahoo.com
Mirowski
Piotr
P
Ludvig
Nandor
N
Carlson
Chad
C
Doyle
Werner
W
Devinsky
Orrin
O
Kuzniecky
Ruben
R
D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D004351:Drug Resistance; D004388:Dura Mater; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007267:Injections; D002538:Intracranial Arteriovenous Malformations / Q000150:complications; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D019635:Neurosurgical Procedures
D000779:Anesthetics, Local; D000927:Anticonvulsants; D008012:Lidocaine