title: Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats.
abstract: In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kgb.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p<0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p<0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kgb.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kgb.w.
authors.affiliation: Division of Industrial Toxicology and Pollution Control, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamilnadu 627412, India. pgsvedhakumar@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Kumar
authors.forename: A G
authors.initials: AG
authors.lastname: Murugesan
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D019660:Malvaceae; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000960:Hypolipidemic Agents; D008079:Lipoproteins, VLDL; D010936:Plant Extracts; D013311:Streptozocin