Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation.
The cortical response to repeated sensory stimuli plateaus (or declines) as repetition frequencies increase beyond 2-8 Hz. This study examined the underlying changes in cortical oxygenated and deoxygenated hemoglobin associated with this phenomenon using near-infrared spectroscopy. The optical signal was measured from 11 healthy volunteers listening to noise-burst trains presented at 2, 10, and 35 Hz. In a bilateral region consistent with the posterior superior temporal gyrus there was an inverse relationship between deoxyhemoglobin concentration change and stimulus frequency: greatest at 2 Hz, intermediate at 10 Hz, and smallest at 35 Hz. These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique.
Weiss
Anthony P
AP
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA. aweiss@partners.org
Duff
Margaret
M
Roffman
Joshua L
JL
Rauch
Scott L
SL
Strangman
Gary E
GE
D000161:Acoustic Stimulation; D000328:Adult; D001303:Auditory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
D006454:Hemoglobins; C100003:deoxyhemoglobin