title: Serotonin syndrome after concomitant treatment with linezolid and meperidine.
abstract: Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors. Meperidine blocks the neuronal reuptake of serotonin. Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described. We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.
authors.affiliation: Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Prabodh K
authors.initials: PK
authors.lastname: Das
authors.forename: Dawn I
authors.initials: DI
authors.lastname: Warkentin
authors.forename: Robert
authors.initials: R
authors.lastname: Hewko
authors.forename: Donna L
authors.initials: DL
authors.lastname: Forrest
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy; D000069349:Linezolid; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects*; D023303:Oxazolidinones / Q000008:administration & dosage / Q000009:adverse effects*; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000150:complications
chemical_list: D000081:Acetamides; D023303:Oxazolidinones; D008614:Meperidine; D000069349:Linezolid