title: Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity.
abstract: OBJECTIVE
  Our objective was to evaluate the clinical significance of angiopoietin-1 (Ang-1) and Ang-2 expression in recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC).
  
  
  METHODS
  Formalin-fixed, paraffin-embedded tissues from 40 patients who underwent surgical intervention for local or local-regional recurrent OCSCC between 1995 and 2005 were immunohistochemically analyzed for Ang-1 and Ang-2 expression.
  
  
  RESULTS
  The recurrent TNM staging classified 5 patients as stage I, 4 as stage II, 2 as stage III, and 29 as stage IV. The actuarial 3-year disease-free survival rate was 43.1% with a mean follow-up of 18.4 months (ranged 1-70 months). High expression of Ang-1 was significantly correlated with positive nodal stage (P = 0.041). Patients with more advanced recurrent stage of the tumors (P = 0.0036) and high expression of Ang-2 (P = 0.045) showed lower actuarial 3-year disease-free survival. However, Cox's regression analysis revealed that only recurrent tumor (rT) stage was an independent prognostic factor for survival (P = 0.019, 95% CI = 1.473-82.017, relative risk = 10.992).
  
  
  CONCLUSIONS
  Recurrent OCSCC with high Ang-1 or Ang-2 expression in the tumor bed exhibits aggressive tumor behavior. However, the salvage outcome depends on the rT stage.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chih-Yen
authors.initials: CY
authors.lastname: Chien
authors.forename: Chih-Ying
authors.initials: CY
authors.lastname: Su
authors.forename: Hui-Ching
authors.initials: HC
authors.lastname: Chuang
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Fang
authors.forename: Hsuan-Ying
authors.initials: HY
authors.lastname: Huang
authors.forename: Ching-Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Chang-Han
authors.initials: CH
authors.lastname: Chen
authors.forename: Chao-Cheng
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042683:Angiopoietin-1 / Q000378:metabolism*; D042702:Angiopoietin-2 / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D010865:Pilot Projects; D011237:Predictive Value of Tests; D016019:Survival Analysis
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2