title: Association between hepatitis B surface antibody seropositivity and coronary artery disease.
abstract: BACKGROUND
  Specific infectious agents have been found to be related to the pathogenesis of coronary atherosclerosis.
  
  
  OBJECTIVE
  We assessed the possible association between angiographically proven coronary artery disease (CAD) and hepatitis B surface antibody (HBS Ab) seropositivity in a population with relatively high prevalence of hepatitis B virus (HBV) infection.
  
  
  METHODS
  This was a cross-sectional study.
  
  
  METHODS
  We analyzed data from 830 consecutive subjects undergoing coronary angiography, including angiographic results reported by two cardiologists for inter-observer reliability and assessment of HBS Ab status determined by enzyme-linked immunosorbent assay (ELISA).
  
  
  METHODS
  Chi-square test or Fisher's exact test, independent two-sample t test and the Pearson's Correlation Coefficient test were used, as required. Statistics were performed using SPSS software version 13 (SPSS, Chicago, IL).
  
  
  RESULTS
  Two hundred forty-nine (30%) subjects had normal angiogram or minimal CAD, and 581 (70%) had significant CAD in at least one major coronary artery. In patients with CAD and in patients without angiographic evidence of significant atherosclerosis, 28.7% and 28.9% respectively were positive for HBV (P=0.954). Mean C-reactive protein levels in subjects with positive and negative HBS Ab were 10.77+/-8.37 mg/L versus 10.33+/-7.64 mg/L respectively (P=0.465). However, C-reactive protein levels in CAD group were significantly higher (P<0.001).
  
  
  CONCLUSIONS
  Our results suggested hepatitis B surface antibody seropositivity has no relationship with coronary artery disease. Moreover, no significant linear correlation exists between HBS Ab and C-reactive protein levels. However, as previously shown, C-reactive protein level in patients with coronary artery disease is significantly higher than in patients with normal coronary arteries.
authors.affiliation: Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Amirzadegan
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Davoodi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Boroumand
authors.forename: Sirous
authors.initials: S
authors.lastname: Darabyan
authors.forename: Maria Raissi
authors.initials: MR
authors.lastname: Dehkordi
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Goodarzynejad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens