title: Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings.
abstract: Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
authors.affiliation: Department of Pathology, Inha University College of Medicine, 7-206 Shinheung- dong 3 ga, Joong-gu, Incheon 400-711, Korea.
authors.forename: Suk Jin
authors.initials: SJ
authors.lastname: Choi
authors.forename: Joon Mee
authors.initials: JM
authors.lastname: Kim
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Han
authors.forename: Seung Ik
authors.initials: SI
authors.lastname: Ahn
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Lucia
authors.initials: L
authors.lastname: Kim
authors.forename: In Suh
authors.initials: IS
authors.lastname: Park
authors.forename: Young Chae
authors.initials: YC
authors.lastname: Chu
mesh_terms: D000369:Aged, 80 and over; D019002:CD56 Antigen / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D002864:Chromogranins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry / Q000473:pathology*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D019002:CD56 Antigen; D002864:Chromogranins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase