title: Association of the serotonin transporter gene, neuroticism and smoking behaviours.
abstract: Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK. colin.ogara@sjog.ie.|St. John of God Hospital, Stillorgan, Co Dublin, Ireland. colin.ogara@sjog.ie.
authors.forename: Colin
authors.initials: C
authors.lastname: O'Gara
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Jo
authors.initials: J
authors.lastname: Knight
authors.affiliation: Tobacco Research Unit, National Addiction Centre, Institute of Psychiatry, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Stapleton
authors.affiliation: South Essex Partnership NHS Trust, The Taylor Centre, Queensway House, Essex Street, Southend on Sea, Essex, SS4 1RB, UK.
authors.forename: Jason
authors.initials: J
authors.lastname: Luty
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Neale
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Matt
authors.initials: M
authors.lastname: Nash
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Patricia
authors.initials: P
authors.lastname: Heuzo-Diaz
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Farzana
authors.initials: F
authors.lastname: Hoda
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen
authors.affiliation: Tobacco Research Unit, National Addiction Centre, Institute of Psychiatry, London, UK.
authors.forename: Gay
authors.initials: G
authors.lastname: Sutherland
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Collier
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Pak
authors.initials: P
authors.lastname: Sham
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Ball
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, King's College London, Institute of Psychiatry, London, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Craig
mesh_terms: D016001:Confidence Intervals; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009497:Neurotic Disorders / Q000235:genetics* / Q000523:psychology; D010551:Personality; D040641:Quantitative Trait Loci; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D016540:Smoking Cessation / Q000706:statistics & numerical data
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins