Different epidermal growth factor receptor gene mutations in a patient with 2 synchronous lung cancers.
Recently, the frequency of lung adenocarcinoma has been increasing among nonsmokers, though the etiology remains unclear. Mutations of the epidermal growth factor receptor (EGFR) gene are frequently detected in the lung adenocarcinomas seen in nonsmokers. Thus, EGFR mutations can be implicated in carcinogenesis of lung adenocarcinoma. Herein, we report a case of 2 synchronous lung adenocarcinomas composed of 2 distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary subtype of adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma. These findings suggest that specific mutations can occur randomly in the EGFR hot spot, and that these EGFR mutations can contribute to the distinct carcinogenic process of each adenocarcinoma.
Nakano
Hirofumi
H
Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Soda
Hiroshi
H
Nakamura
Yoichi
Y
Uchida
Kanako
K
Takasu
Mineyo
M
Nakatomi
Katsumi
K
Izumikawa
Kinichi
K
Hayashi
Tomayoshi
T
Nagayasu
Takeshi
T
Tsukamoto
Kazuhiro
K
Kohno
Shigeru
S
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology; D019943:Amino Acid Substitution; D001483:Base Sequence; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
D066246:ErbB Receptors