Comparison of serum and follicular fluid hormone levels with recombinant and urinary human chorionic gonadotropin during in vitro fertilization.
OBJECTIVE
To study serum and follicular fluid (FF) hormone levels after the administration of urinary or recombinant hCG to initiate the final stages of oocyte maturation during IVF.


METHODS
Prospective randomized study between 250 microg of recombinant hCG and 7,500 IU of urinary hCG as the final trigger of ovulation during IVF.


METHODS
Private IVF center.


METHODS
Infertile women undergoing IVF/intracytoplasmic sperm injection (ICSI) using the long protocol and recombinant FSH.


METHODS
IVF treatment. Serum and FF hormone measurements on the day of oocyte collection.


METHODS
Serum and FF E(2), P, hCG, and T levels.


RESULTS
Stimulation parameters, serum and follicular E(2), P, T, and hCG levels were similar in the recombinant and urinary hCG groups. The number of oocytes retrieved from follicles >14 mm, the proportion of mature oocytes, fertilization rate, and pregnancy rate (PR) were also comparable.


CONCLUSIONS
Recombinant and urinary hCG provided similar serum and follicular hormonal environments during the final stages of oocyte maturation. The IVF outcome parameters were also comparable. The two medications appear to be equally effective.
Kovacs
Peter
P
Kaali Institute IVF Center, Budapest, Hungary. peterkovacs1970@hotmail.com
Kovats
Timea
T
Bernard
Artur
A
Zadori
Janos
J
Szmatona
Gabor
G
Kaali
Steven G
SG
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use* / Q000652:urine; D004624:Embryo Transfer; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006814:Hungary; D007246:Infertility / Q000378:metabolism / Q000628:therapy*; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D013739:Testosterone / Q000378:metabolism; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D006728:Hormones; D011994:Recombinant Proteins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol