Mouse models of tooth abnormalities.
Tooth number is abnormal in about 20% of the human population. The most common defect is agenesis of the third molars, followed by loss of the lateral incisors and loss of the second premolars. Tooth loss appears as both a feature of multi-organ syndromes and as a non-syndromic isolated character. Apart from tooth number, abnormalities are also observed in tooth size, shape, and structure. Many of the genes that underlie dental defects have been identified, and several mouse models have been created to allow functional studies to understand, in greater detail, the role of particular genes in tooth development. The ability to manipulate the mouse embryo using explant culture and genome targeting provides a wealth of information that ultimately may pave the way for better diagnostics, treatment or even cures for human dental disorders. This review aims to summarize recent knowledge obtained in mouse models, which can be used to gain a better understanding of the molecular basis of human dental abnormalities.
Fleischmannova
Jana
J
Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic. fleisj03@bf.jcu.cz
Matalova
Eva
E
Tucker
Abigail S
AS
Sharpe
Paul T
PT
D000818:Animals; D000848:Anodontia / Q000235:genetics; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000235:genetics; D003743:Dental Enamel / Q000002:abnormalities* / Q000196:embryology; D003804:Dentin / Q000002:abnormalities* / Q000196:embryology; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009805:Odontogenesis / Q000235:genetics*; D010519:Periodontium / Q000002:abnormalities; D010641:Phenotype; D010750:Phosphoproteins / Q000235:genetics; D014071:Tooth Abnormalities / Q000196:embryology / Q000235:genetics* / Q000473:pathology; D014096:Tooth, Supernumerary / Q000196:embryology / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
C525809:BMP4 protein, human; C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D014157:Transcription Factors; C486419:Trp63 protein, mouse