title: [Branched antimicrobial peptides].
abstract: Branched peptides E(RLAR)2, E[E(RLAR)2]2, E(KLAR)2, and E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 microM for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Khrushchev
authors.forename: I A
authors.initials: IA
authors.lastname: Kashparov
authors.forename: L V
authors.initials: LV
authors.lastname: Klimenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mitin
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D005971:Glutamates / Q000737:chemistry; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry*; D005466:Fluorocarbons
chemical_list: D023181:Antimicrobial Cationic Peptides; D005971:Glutamates; D009842:Oligopeptides; C526700:arginyl-leucyl-alanyl-arginine; C526702:glutamic acid bis(pentafluorophenyl)ester; D005466:Fluorocarbons; C526701:lysyl-leucyl-alanyl-arginine