title: From prebiotic chemistry to cellular metabolism--the chemical evolution of metabolism before Darwinian natural selection.
abstract: It is generally assumed that the complex map of metabolism is a result of natural selection working at the molecular level. However, natural selection can only work on entities that have three basic features: information, metabolism and membrane. Metabolism must include the capability of producing all cellular structures, as well as energy (ATP), from external sources; information must be established on a material that allows its perpetuity, in order to safeguard the goals achieved; and membranes must be able to preserve the internal material, determining a selective exchange with external material in order to ensure that both metabolism and information can be individualized. It is not difficult to understand that protocellular entities that boast these three qualities can evolve through natural selection. The problem is rather to explain the origin of such features under conditions where natural selection could not work. In the present work we propose that these protocells could be built by chemical evolution, starting from the prebiotic primordial soup, by means of chemical selection. This consists of selective increases of the rates of certain specific reactions because of the kinetic or thermodynamic features of the process, such as stoichiometric catalysis or autocatalysis, cooperativity and others, thereby promoting their prevalence among the whole set of chemical possibilities. Our results show that all chemical processes necessary for yielding the basic materials that natural selection needs to work may be achieved through chemical selection, thus suggesting a way for life to begin.
authors.affiliation: Instituto del Metabolismo Celular, Calle Manuel de Falla no. 15, La Laguna, 38208 Tenerife, Canary Islands, Spain. biochem@metabolismo.ws
authors.forename: Enrique
authors.initials: E
authors.lastname: Meléndez-Hevia
authors.forename: Nancy
authors.initials: N
authors.lastname: Montero-Gómez
authors.forename: Francisco
authors.initials: F
authors.lastname: Montero
mesh_terms: D000818:Animals; D003067:Coenzymes / Q000502:physiology; D019418:Evolution, Chemical; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008660:Metabolism / Q000235:genetics*; D000069497:Origin of Life; D012641:Selection, Genetic
chemical_list: D003067:Coenzymes