title: Childhood onset demyelination and Graves' disease: shared antigen or autoimmune clustering?
abstract: We describe a case of concomitant Graves' disease and demyelination, with optic neuritis and cerebellar dysfunction, in an adolescent girl. Autoimmune thyroid disease with encephalopathy is the hallmark of Hashimoto's encephalopathy, linking thyroid and central nervous system dysfunction. However, to our knowledge, Graves' disease has not been previously reported in association with clinically isolated demyelinating disease in childhood.
authors.affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of Alberta, Edmonton, Canada. rebeccam@ualberta.ca
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Mitchell
authors.forename: Jerome Y
authors.initials: JY
authors.lastname: Yager
authors.forename: Seth D
authors.initials: SD
authors.lastname: Marks
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D001324:Autoantigens / Q000276:immunology*; D001921:Brain / Q000473:pathology; D002648:Child; D016000:Cluster Analysis; D003711:Demyelinating Diseases / Q000276:immunology* / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008713:Methimazole / Q000627:therapeutic use; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology
chemical_list: D013956:Antithyroid Agents; D001324:Autoantigens; D008713:Methimazole