title: How IRE1 reacts to ER stress.
abstract: The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.
authors.affiliation: Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. ron@saturn.med.nyu.edu
authors.forename: David
authors.initials: D
authors.lastname: Ron
authors.forename: Stevan R
authors.initials: SR
authors.lastname: Hubbard
mesh_terms: D017398:Alternative Splicing / Q000502:physiology; D020134:Catalytic Domain / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D004722:Endoribonucleases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D010770:Phosphotransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; D010770:Phosphotransferases; C082863:IRE1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases