Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis.
Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) significantly accelerates progression to allograft cirrhosis. Current biochemical parameters to monitor progression of chronic HCV after OLT have yielded low specificity and sensitivity. Here we investigated the HCV-specific immunity and serum levels of soluble CD30 (sCD30), a novel marker of Th2 immunity, in patients with and without allograft cirrhosis. Patients with hepatic inflammation but no cirrhosis (HIN, n=20) revealed elevated serum interferon (IFN)-gamma and high frequency of IFN-gamma producing CD4 T(h1) cells compared to those with hepatic cirrhosis (HFC, n=20) that had high interleukin (IL)-5 and IL-5 producing CD4 T(h2) cells. Patients with HFC, but not HIN, were found to have significantly higher levels of sCD30. Therefore, we conclude that lack of optimal Th1-type CD4 T cells is associated with HCV-induced allograft cirrhosis. Further, sCD30 may represent a novel marker for surveillance of hepatic cirrhosis in transplant recipients with chronic HCV infection.
Bharat
Ankit
A
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Narayanan
Kishore
K
Golocheikine
Anjali
A
Steward
Nancy
N
Crippin
Jeffrey
J
Lisker-Melman
Mauricio
M
Shenoy
Surendra
S
Lowell
Jeffrey
J
Chapman
William C
WC
Mohanakumar
Thalachallour
T
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D017730:Ki-1 Antigen / Q000097:blood*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000821:virology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000821:virology; D014184:Transplantation, Homologous
D015703:Antigens, CD; D015415:Biomarkers; D017730:Ki-1 Antigen; D007371:Interferon-gamma