title: Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate?
abstract: BACKGROUND
  Present surgical opinion is divided regarding the optimal method for the treatment of duodenal gastrointestinal stromal tumor (GIST) with some supporting the selective use of limited resection (LR) versus others who prefer pancreaticoduodenectomy (PD).
  
  
  METHODS
  A retrospective review of 22 patients who underwent surgery for suspected GIST involving the duodenum.
  
  
  RESULTS
  There were 15 GISTs, 1 leiomyosarcoma and 6 other non-GIST benign submucosal tumors. Seven patients underwent LR and seven underwent PD for GIST. The median follow-up was 42 (range, 2-174) months. Patients who underwent LR versus PD had similar mean disease-specific survival [144 (95% CI, 92-196) vs. 130 (95% CI, 82-127) months, P = 0.808] and recurrence rates (14% vs. 29%, P = 0.515). All recurrences occurred at distant sites. Comparison between LR versus PD demonstrated that LR was associated with a significantly shorter operation time [125 (range, 50-305) vs. 350 (range, 210-465) min., P = 0.001] but similar morbidity rate (23% vs. 43%, P = 0.357). Comparison between GIST and other benign tumors demonstrated that size was the only statistically significant distinguishing factor [8.5 (range, 2.5-18.0) vs. 2.5 (range, 1.5-8.0) cm, P = 0.014].
  
  
  CONCLUSIONS
  Benign non-GIST tumors may be distinguished from duodenal GIST as they are smaller in size. LR is a viable treatment option for suspected GIST involving the duodenum.
authors.affiliation: Department of Surgery, Singapore General Hospital, Singapore.
authors.forename: Brian K P
authors.initials: BK
authors.lastname: Goh
authors.forename: Pierce K H
authors.initials: PK
authors.lastname: Chow
authors.forename: Sittampalam
authors.initials: S
authors.lastname: Kesavan
authors.forename: Wai-Ming
authors.initials: WM
authors.lastname: Yap
authors.forename: Wai-Keong
authors.initials: WK
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D013505:Digestive System Surgical Procedures; D004379:Duodenal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018204:Neoplasms, Connective and Soft Tissue / Q000401:mortality / Q000473:pathology / Q000601:surgery; D017063:Outcome Assessment, Health Care; D010235:Paraganglioma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D013997:Time Factors