title: A comprehensive approach to treating autism and attention-deficit hyperactivity disorder: a prepilot study.
abstract: OBJECTIVE
  The purpose of this study was to observe the effects of a multi dimensional treatment plan involving nutrition, environmental control, chelation, and behavioral/educational/physical/speech therapy to treat children with autistic spectrum disorder and attention-deficit hyperactivity (ADHD) disorder. This study is only a preliminary study, and its small size (10 patients) precludes statistical analysis of simultaneous multiple modal treatment regimes.
  
  
  METHODS
  This was an open-label observational study. SETTINGS/LOCATION/SUBJECTS: This study examined 10 children aged 4-10 years old who had been diagnosed with both autistic spectrum disorder and ADHD by outside physicians or psychologists. These 10 children presented consecutively in an environmental medicine clinic in Buffalo, New York. The children were given comprehensive nutritional/environmental/chelation treatment for 3 to 6 months in addition to their usual behavioral, educational, speech, and physical therapies.
  
  
  METHODS
  Study outcomes were measured by objective/subjective improvement as judged by physicians/parents/teachers. Outcomes were also measured by changes in urinary heavy metal burdens over time.
  
  
  RESULTS
  All 10 children showed significant improvement in many areas of social interaction, concentration, writing, language, and behavior. Urinary lead burden dropped significantly in all 10 children.
  
  
  CONCLUSIONS
  Autistic spectrum disorders and ADHD are complicated conditions that probably require multidimensional treatment strategies. Larger studies are needed to determine optimum treatment plans involving nutrition, environmental control, medication, and behavioral/education/speech/physical therapies.
authors.affiliation: Environmental Health Center, Buffalo, NY., Department of Pediatrics, State University of NewYork, Buffalo, NY 14225, USA. aehcwny@Juno.com
authors.forename: Kalpana
authors.initials: K
authors.lastname: Patel
authors.forename: Luke T
authors.initials: LT
authors.lastname: Curtis
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000628:therapy*; D001321:Autistic Disorder / Q000628:therapy*; D001521:Behavior Therapy / Q000379:methods*; D015913:Chelation Therapy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009518:New York; D044623:Nutrition Therapy / Q000379:methods*; D010865:Pilot Projects; D012107:Research Design; D016896:Treatment Outcome