IgA nephropathy associated with leukemia and lymphoma: report of two cases.
IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years before the onset of non-Hodgkin lymphoma, and hematuria continued during chemotherapy. Each disease occurred after a long interval, and the clinical courses did not run parallel. The association was thought to be incidental in our cases. Chemotherapy with adrenocorticosteroids and immunosuppressants [6-mercaptopurine (6-MP) and cyclophosphamide (CY)] for leukemia and lymphoma did not affect the clinical course of IgAN.
Motoyama
Osamu
O
Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan. motoyan@basil.ocn.ne.jp.
Kojima
Yasuko
Y
Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Ohara
Akira
A
Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Tsukimoto
Ichirou
I
Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Ishikawa
Yukio
Y
Department of Pathology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Iitaka
Kikuo
K
Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Shizuoka, Japan.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006417:Hematuria / Q000209:etiology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure*; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
D000305:Adrenal Cortex Hormones; D007070:Immunoglobulin A; D007166:Immunosuppressive Agents; D004176:Dipyridamole