title: Lack of efficacy of high-dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection.
abstract: Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc gamma receptors is not a primary mechanism in this disease.
authors.affiliation: Department of Blood Borne Diseases, San Lazaro Hospital, Manila, Research and Biotechnology Division, St. Luke's Medical Center, Quezon City, The Philippines .
authors.forename: Efren M
authors.initials: EM
authors.lastname: Dimaano
authors.forename: Mariko
authors.initials: M
authors.lastname: Saito
authors.forename: Shoko
authors.initials: S
authors.lastname: Honda
authors.forename: Edna A
authors.initials: EA
authors.lastname: Miranda
authors.forename: Maria T G
authors.initials: MT
authors.lastname: Alonzo
authors.forename: Myra D
authors.initials: MD
authors.lastname: Valerio
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Mapua
authors.forename: Shingo
authors.initials: S
authors.lastname: Inoue
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumaori
authors.forename: Ronald
authors.initials: R
authors.lastname: Matias
authors.forename: Filipinas F
authors.initials: FF
authors.lastname: Natividad
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oishi
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology; D002648:Child; D003715:Dengue / Q000150:complications* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D010679:Philippines; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors