title: Advanced technologies and devices for inhalational anesthetic drug dosing.
abstract: Technological advances in micromechanics, optical sensing, and computing have led to innovative and reliable concepts of precise dosing and sensing of modern volatile anesthetics. Mixing of saturated desflurane flow with fresh gas flow (FGF) requires differential pressure sensing between the two circuits for precise delivery. The medical gas xenon is administered most economically in a closed circuit breathing system. Sensing of xenon in the breathing system is achieved with miniaturized and unique gas detector systems. Innovative sensing principles such as thermal conductivity and sound velocity are applied. The combination of direct injection of volatile anesthetics and low-flow in a closed circuit system requires simultaneous sensing of the inhaled and exhaled gas concentrations. When anesthetic conserving devices are used for sedation with volatile anesthetics, regular gas concentration monitoring is advised. High minimal alveolar concentration (MAC) of some anesthetics and low-flow conditions bear the risk of hypoxic gas delivery. Oxygen sensing based on paramagnetic thermal transduction has become the choice when long lifetime and one-time calibration are required. Compact design of beam splitters, infrared filters, and detectors have led to multiple spectra detector systems that fit in thimble-sized housings. Response times of less than 500 ms allow systems to distinguish inhaled from exhaled gas concentrations. The compact gas detector systems are a prerequisite to provide "quantitative anesthesia" in closed circuit feedback-controlled breathing systems. Advanced anesthesia devices in closed circuit mode employ multiple feedback systems. Multiple feedbacks include controls of volume, concentrations of anesthetics, and concentration of oxygen with a corresponding safety system. In the ideal case, the feedback system delivers precisely what the patient is consuming. In this chapter, we introduce advanced technologies and device concepts for delivering inhalational anesthetic drugs. First, modern vaporizers are described with special attention to the particularities of delivering desflurane. Delivery of xenon is presented, followed by a discussion of direct injection of volatile anesthetics and of a device designed to conserve anesthetic drugs. Next, innovative sensing technologies are presented for reliable control and precise metering of the delivered volatile anesthetics. Finally, we discuss the technical challenges of automatic control in low-flow and closed circuit breathing systems in anesthesia.
authors.affiliation: Drägerwerk Aktiengesellschaft, Moislinger Allee 53-55, 23542, Lübeck, Germany. joerg-uwe.meyer@draeger.com
authors.forename: J-U
authors.initials: JU
authors.lastname: Meyer
authors.forename: G
authors.initials: G
authors.lastname: Kullik
authors.forename: N
authors.initials: N
authors.lastname: Wruck
authors.forename: K
authors.initials: K
authors.lastname: Kück
authors.forename: J
authors.initials: J
authors.lastname: Manigel
mesh_terms: D000280:Administration, Inhalation; D000764:Anesthesia, Closed-Circuit; D000769:Anesthesia, Inhalation / Q000295:instrumentation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D001331:Automation; D002490:Central Nervous System / Q000187:drug effects*; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004867:Equipment Design; D006801:Humans; D008954:Models, Biological; D015203:Reproducibility of Results
chemical_list: D018685:Anesthetics, Inhalation