title: Effect of liquid pancreatic enzymes on the assimilation of fat in different liquid formula diets.
abstract: BACKGROUND
  In some diseases, patients require high-calorie tube feeding with standard enteral formulas usually administered via temporal feeding tubes. One frequent pathophysiological condition in a relevant number of these patients is exocrine pancreatic insufficiency. Patients unable to swallow capsules might benefit from a liquid pancreatic enzyme (LPE) preparation.
  
  
  METHODS
  LPEs were prepared and mixed with different commercially available formula diets produced for enteral feeding. Lipolysis was then measured by fatty acid titration.
  
  
  RESULTS
  Complete lipolysis by liquid enzyme preparations was observed in diverse formula diets. Fat assimilation was even complete when LPE had been prepared 3.5 hours before the experiments, showing that the enzymes had been stable up to that time.
  
  
  CONCLUSIONS
  The use of LPEs seems to be a good therapeutic option in patients with exocrine pancreatic insufficiency and the need for permanent high-calorie enteral feeding. Pharmaceutical companies should therefore be further encouraged to develop and distribute liquid enzyme preparations.
authors.affiliation: Third Medical Department, University Hospital Giessen und Marburg, Giessen, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Hauenschild
authors.forename: Nils
authors.initials: N
authors.lastname: Ewald
authors.forename: Thorsten
authors.initials: T
authors.lastname: Klauke
authors.forename: Ariane
authors.initials: A
authors.lastname: Liebchen
authors.forename: Reinhard Georg
authors.initials: RG
authors.lastname: Bretzel
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kloer
authors.forename: Philip Daniel
authors.initials: PD
authors.lastname: Hardt
mesh_terms: D004750:Enteral Nutrition; D010188:Exocrine Pancreatic Insufficiency / Q000628:therapy*; D005526:Food, Formulated; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D010179:Pancreas / Q000201:enzymology* / Q000378:metabolism; D010184:Pancreatic Extracts / Q000008:administration & dosage*; D010194:Pancreatin / Q000008:administration & dosage; D020799:Pancrelipase / Q000008:administration & dosage
chemical_list: D010184:Pancreatic Extracts; D020799:Pancrelipase; D010194:Pancreatin