title: Exposition to chickenpox of two children with autoinflammatory syndromes under treatment with anakinra.
abstract: We report two children with autoinflammatory syndromes treated with anakinra who came in contact with the varicella-zoster virus after being exposed accidentally to infected children: both cases were managed prophylactically with specific antichickenpox intravenous immunoglobulins and anakinra temporary suspension; neither adverse events nor complications related to the natural course of chickenpox were experienced by the two patients. The risk of developing infectious events should be closely monitored, because of the absence of data concerning long-term safety of biological agents in the pediatric age, and prevention strategies should be highly encouraged before they are started.
authors.affiliation: Department of Pediatric Sciences, Center of Periodic Fevers, Università Cattolica Sacro Cuore, Rome, Italy. drigante@gmail.com
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Valentina
authors.initials: V
authors.lastname: Ansuini
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berrettini
authors.forename: Giulia
authors.initials: G
authors.lastname: Bersani
authors.forename: Achille
authors.initials: A
authors.lastname: Stabile
mesh_terms: D000015:Abnormalities, Multiple / Q000188:drug therapy*; D002644:Chickenpox / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D008297:Male; D013577:Syndrome
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein