title: Vancomycin-resistant enterococcal meningitis treated with intrathecal streptomycin.
abstract: Enterococcal meningitis is a rare complication of neurosurgical procedures. We present a patient who developed vancomycin-resistant enterococcal ventriculitis - meningitis after a brain tumor resection and ventriculoperitoneal shunt placement, treated successfully with intrathecal streptomycin through bilateral cerebrospinal fluid drainage catheters in addition to systemic antibiotics. This is the first report of such treatment for this resistant organism.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, United States. varelas@neuro.hfh.edu
authors.forename: Panayiotis N
authors.initials: PN
authors.lastname: Varelas
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rehman
authors.forename: Wendy
authors.initials: W
authors.lastname: Pierce
authors.forename: Jody
authors.initials: J
authors.lastname: Wellwood
authors.forename: Thea
authors.initials: T
authors.lastname: Chua
authors.forename: Sanjay
authors.initials: S
authors.lastname: Revankar
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D013293:Enterococcus faecalis / Q000187:drug effects; D005625:Frontal Lobe / Q000601:surgery*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008545:Melanoma / Q000556:secondary* / Q000601:surgery; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008866:Microsurgery; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D016634:Radiosurgery; D012086:Reoperation; D012878:Skin Neoplasms / Q000601:surgery*; D013307:Streptomycin / Q000008:administration & dosage*; D020713:Vancomycin Resistance; D017287:Ventriculoperitoneal Shunt; D014696:Ventriculostomy
chemical_list: D000900:Anti-Bacterial Agents; D013307:Streptomycin