title: Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations.
abstract: OBJECTIVE
  This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population.
  
  
  METHODS
  This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions.
  
  
  RESULTS
  One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001).
  
  
  CONCLUSIONS
  In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.
authors.affiliation: Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
authors.forename: Bryna
authors.initials: B
authors.lastname: Harwood
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Meyn
authors.forename: Susan A
authors.initials: SA
authors.lastname: Ballagh
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Raymond
authors.forename: David F
authors.initials: DF
authors.lastname: Archer
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Creinin
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects / Q000473:pathology*; D003127:Colposcopy / Q000379:methods; D017280:Condoms; D016001:Confidence Intervals; D003267:Contraception; D003274:Contraceptive Devices, Female; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017137:Nonoxynol / Q000008:administration & dosage*; D016017:Odds Ratio; D011336:Probability; D012016:Reference Values; D012749:Sexually Transmitted Diseases / Q000517:prevention & control; D013089:Spermatocidal Agents / Q000008:administration & dosage*; D014621:Vagina / Q000187:drug effects / Q000473:pathology*
chemical_list: D013089:Spermatocidal Agents; D017137:Nonoxynol