Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents.
An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
Pettit
George R
GR
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe 85287-2404, USA. bpettit@asu.edu
Mukku
Venugopal J R V
VJ
Cragg
Gordon
G
Herald
Delbert L
DL
Knight
John C
JC
Herald
Cherry L
CL
Chapuis
Jean-Charles
JC
D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027844:Vitaceae / Q000737:chemistry*
C527627:22-epicalamistrin; D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic