title: Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT.
abstract: Idiopathic rapid-eye-movement (REM) sleep behavior disorder (iRBD) has been suggested to be a risk factor for subsequent development of neurodegenerative disorders, especially Parkinson's disease (PD) and other alpha-synucleinopathies. At present, it is not possible to predict whether or not an iRBD patient will eventually develop PD. Here, we report 5 iRBD patients who underwent a test battery comprising a neurological examination (including UPDRS rating), mini mental state examination testing, transcranial sonography, olfactory function testing, and presynaptic dopamine transporter imaging with FP-CIT-SPECT. Our preliminary data show the diverse pattern of individual combinations of pathological findings when a multimodal assessment approach is applied in this patient group. Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD.
authors.affiliation: Department of Neurology, Philipps-Universität Marburg, Germany. marcus.unger@med.uni-marburg.de
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Unger
authors.forename: Jens C
authors.initials: JC
authors.lastname: Möller
authors.forename: Karin
authors.initials: K
authors.lastname: Stiasny-Kolster
authors.forename: Katharina
authors.initials: K
authors.lastname: Mankel
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Uwe
authors.initials: U
authors.lastname: Walter
authors.forename: Helmut
authors.initials: H
authors.lastname: Hoeffken
authors.forename: Geert
authors.initials: G
authors.lastname: Mayer
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000453:epidemiology*; D019275:Radiopharmaceuticals; D012720:Severity of Illness Index; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane