Assessment of cadaveric livers discarded from transplantation. A correlation between clinical and histological parameters.
BACKGROUND
We designed a study with the following aims: to assess tissue quality of 100 cadaveric livers discarded from transplantation, to identify discarded organs which could have been used either for transplantation or for isolation of hepatocytes, to assess donor clinical factors which may impact the histology.


METHODS
Liver wedge biopsies were performed during kidney procurement, sent for processing and data interpretation.


RESULTS
In 46% of the evaluated tissues severe changes were found; these organs according to pathologists were "not suitable for transplantation". In 19% less pronounced changes classified organs as "probably not suitable for transplantation". In 35% biopsies only minimal changes were found; these organs were classified as "probably suitable for transplantation" and could have been harvested as marginal organs or at least used for hepatocytes isolation.


CONCLUSIONS
Results of biopsies suggested that approximately in one third of livers discarded from transplantation due to clinical donor parameters could have been harvested from histological point of view. Several donor clinical risk factors (alcohol addiction, hyperbilirubinemia, increased transaminase activity) correlate with severe histological changes rending the liver "not suitable for transplantation".
Czerwiński
Jarosław
J
Department of Surgical and Transplant Nursing, Medical University of Warsaw, Poland.
Perkowska
Agnieszka
A
Mróz
Andrzej
A
Lagiewska
Beata
B
Adadyński
Leszek
L
Durlik
Magdalena
M
Głyda
Maciej
M
Lisik
Wojciech
W
Pacholczyk
Marek
M
Paczek
Leszek
L
Polak
Wojciech
W
Sledzinski
Zbigniew
Z
Wasiak
Dariusz
D
Włodarczyk
Zbigniew
Z
Wałaszewski
Janusz
J
Małkowski
Piotr
P
Chmura
Andrzej
A
Rowiński
Wojciech
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002102:Cadaver; D002469:Cell Separation; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation; D008875:Middle Aged; D012307:Risk Factors; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000592:standards*; D019737:Transplants / Q000592:standards*