Nanofibrous poly(lactic acid)/hydroxyapatite composite scaffolds for guided tissue regeneration.
The production of nanofibrous PLA/HA composite scaffolds is described. The morphological, mechanical, surface, and thermal properties of the composites were extensively investigated. The results show that the mixture of PLA and HA formed smooth nanofibers without lumps. The incorporation of HA increased the mechanical strength of the nanofibers and changed the morphology, increasing the mean fiber diameter and pore size. Surface and internal properties confirmed that HA was homogeneously distributed inside the nanofibers and oriented towards their surface. The nanofiber composites allowed the adhesion and proliferation of pre-osteoblasts for up to 3 weeks.
Jeong
Sung In
SI
School of Chemical Engineering, College of Engineering, Hanyang University, 17 Haengdang-dong, Seongdong-ku, Seoul 133-791, Republic of Korea.
Ko
Eun Kyoung
EK
Yum
Jungsuk
J
Jung
Chul Ho
CH
Lee
Young Moo
YM
Shin
Heungsoo
H
D016475:3T3 Cells; D000818:Animals; D032701:Biomimetics; D001709:Biotechnology / Q000379:methods*; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D017886:Durapatite / Q000737:chemistry*; D051379:Mice; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism*; D012038:Regeneration; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
D017886:Durapatite