title: [Risks and benefits of hormone replacement therapy].
abstract: In contrast to observational studies, clinical trials examining the efficacy of hormone replacement therapy (HRT) have shown the overall negative or deteriorating effects of HRT in postmenopausal women. Particularly, the results of Women's Health Initiative (WHI) demonstrated that HRT was preventive of fractures and colon cancer but increased the risk of myocardial infarction, stroke and dementia in addition to breast cancer and venous thromboembolism. Conversely, recent progress in androgen research suggests the efficacy of androgen replacement therapy in elderly men, pending clinical trials.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Akishita
mesh_terms: D015914:Estrogen Replacement Therapy; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male