title: Microfluidics for drug discovery and development: from target selection to product lifecycle management.
abstract: Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies and product management.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Kang
authors.forename: Bong Geun
authors.initials: BG
authors.lastname: Chung
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004345:Drug Industry / Q000379:methods*; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*