Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?
A case of multiple malignancies in a 41 year old African American man is described. After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma. We propose a common etiology to these canceres via tumor suppressor gene p53.
Sumrall
Ashley
A
Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA. ashleysumrall@bellsouth.net
Soni
Nilam
N
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D000328:Adult; D018223:Dermatofibrosarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D011859:Radiography; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53