PTRF triggers a cave in.
Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae flatten and caveolin-1 is released into the cell membrane, where it is rapidly internalized and degraded.
Chadda
Rahul
R
National Centre for Biological Sciences, Bellary Road, Bangalore 560 005, India.
Mayor
Satyajit
S
D000818:Animals; D021941:Caveolae / Q000378:metabolism* / Q000648:ultrastructure; D051242:Caveolin 1 / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008565:Membrane Proteins; D051379:Mice; D010766:Phosphorylation; D021381:Protein Transport / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D051242:Caveolin 1; C112745:Cavin1 protein, mouse; D007328:Insulin; D008565:Membrane Proteins; D016601:RNA-Binding Proteins