[Peripheral blood T lymphocyte subtypes in multiple sclerosis--dependance of clinical course and duration of the disease].
Multiple sclerosis is a disease mediated by immunological mechanisms, with characteristics of an autoimmune prosses. We registered changes in distribution of immunophenotipisation markers CD2, CD3, CD4, CD8, CD56 and DR, by indirect immunoflourescence assay, on immune cells of peripheral blood. We tested 20 patients with clinically definite category of illness, in exacerbation, and 10 healthy individuals. Multiple sclerosis patients had changes in distribution of T cell subtypes in exacerbation, which correlated with clinical course and duration of the disease. Relapsing-remitting course of disease is followed by decrease of activated T lymphocytes and fluctuation of CD4+ T lymphocytes, while there are no changes in studied markers at patients with progressive course. Duration of the disease over 10 years is followed by decreases of CD4+ and CD8+ T lymphocytes, independent of course of the disease.
Vojinović
S
S
Vojinović
K
K
Kamenov
B
B
Vojinović
D
D
Gocić-Stanković
D
D
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D016176:T-Lymphocyte Subsets
D015703:Antigens, CD