An experimental model of brain metastasis of lung carcinoma.
Most metastatic brain tumors originate from lung cancers. However, there has been relatively little progress on developing an experimental model of metastasis of lung cancer to the brain. By injecting Lewis lung carcinoma cells into the right internal carotid artery of C57BL/6NCrj mice, we succeeded in developing a model of metastatic brain tumors. In this model, carcinoma cells proliferated in the choroid plexus of the right lateral ventricle and formed a nodular tumor mass, while carcinoma cells in the cerebral parenchyma multiplied along the perivascular sheath without forming a nodular mass. Twelve days after injection, carcinoma cells spread into the left hemicerebrum. Fifteen days after injection, carcinoma cells could be seen in both hemispheres, along with intraventricular tumor formation. The maximum life span of mice with metastatic brain tumors was 22 days. Our model essentially replicated the general process of metastatic cancer and may have a significant role in further research on brain metastasis of lung cancer.
Zhang
Zean
Z
Department of Surgical Pathology, Toho University, School of Medicine, Tokyo, Japan. zeanzh@hotmail.com
Hatori
Tsutomu
T
Nonaka
Hiroko
H
D000818:Animals; D001932:Brain Neoplasms / Q000556:secondary*; D018827:Carcinoma, Lewis Lung / Q000556:secondary*; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation / Q000379:methods