title: Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil.
abstract: Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.
authors.affiliation: Instituto de quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Brazil.
authors.forename: Miriam H
authors.initials: MH
authors.lastname: Kossuga
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Nascimento
authors.forename: Juliana Q
authors.initials: JQ
authors.lastname: Reimão
authors.forename: André G
authors.initials: AG
authors.lastname: Tempone
authors.forename: Noemi Nosomi
authors.initials: NN
authors.lastname: Taniwaki
authors.forename: Katyuscya
authors.initials: K
authors.lastname: Veloso
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Ferreira
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Cavalcanti
authors.forename: Claudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Manoel O
authors.initials: MO
authors.lastname: Moraes
authors.forename: Alejandro M S
authors.initials: AM
authors.lastname: Mayer
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hajdu
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects / Q000648:ultrastructure; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008386:Marine Biology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D020078:Neurogenic Inflammation / Q000188:drug therapy; D009569:Nitric Oxide / Q000096:biosynthesis; D047229:Plakortis / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D018942:Macrolides; C528781:plakortenone; D009569:Nitric Oxide