title: Effect of short-duration electrically induced tachycardia on regional myocardial contractility.
abstract: BACKGROUND
  Tachycardia is a physiological mechanism for adapting cardiac output to modifications in energy consumption in the organism. The repercussions that short-duration tachycardia has on myocardial contractility have not been sufficiently studied.<br /> To study the effects of short-duration tachycardia on regional myocardial function in the anterior face of the left ventricle depending on the rate, duration, and origin of the electrical stimulation producing the tachycardia.
  
  
  METHODS
  Two series were studied in an in vivo canine experimental model. Stimulation was performed in the right atrium and in the base of the left ventricle at a frequency 20 and 40% above the basal rate. The duration of each pacing episode was 10, 20, and 40 minutes followed by a recovery period of 40 minutes. ECG, left ventricular pressure, and regional function curves of a myocardial segment were studied.
  
  
  RESULTS
  During atrial pacing there was a similar decrease in both regional segment lengths (end-systolic and end-diastolic lengths) and no variation in the shortening fraction or in hemodynamic parameters. During ventricular pacing, systolic pressure in the left ventricle decreased, end-diastolic pressure increased, end-diastolic length shortened (meaning less ventricular filling), and the end-systolic length increased, leading to a reduced shortening fraction or regional contractility alteration which was temporarily maintained once pacing ceased.
  
  
  CONCLUSIONS
  The transient persistence of segment dysfunction after induced ventricular tachycardia ceases indicates the activation of a different, unknown mechanism.
authors.affiliation: Cardiocirculatory Unit, Investigation Centre of La Fe Hospital, Valencia, Spain. hernandiz_amp@gva.es
authors.forename: Amparo
authors.initials: A
authors.lastname: Hernándiz
authors.forename: Juan A
authors.initials: JA
authors.lastname: Cosin-Aguilar
authors.forename: Amparo
authors.initials: A
authors.lastname: Aguilar
authors.forename: José Luis
authors.initials: JL
authors.lastname: Díez
mesh_terms: D000818:Animals; D002302:Cardiac Output; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology