title: Estimation of tissue's elasticity with surface wave speed.
abstract: The mechanical response of tissues to external forces has gained considerable interest in medical diagnosis. One approach to imaging tissue elastic properties is to apply an external force on the surface of the body. Another approach is to generate a localized force inside the tissue with the radiation force of ultrasound. In this paper, a new method is developed to estimate tissue's elasticity based on surface wave speed measurement. The theory of surface wave speed is developed for estimating tissue's elasticity. Experiments are carried out on a tissue-mimicking ultrasound phantom. An amplitude modulated ultrasound signal of a few hundred hertz is used to generate a localized force in the phantom. The surface wave fields are measured with a laser vibrometer. It shows that the surface wave speed can be used for inversely estimating tissue's elastic properties based on tissue's surface measurement.
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA. zhang.xiaoming@mayo.edu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
authors.forename: James F
authors.initials: JF
authors.lastname: Greenleaf
mesh_terms: D004548:Elasticity; D006801:Humans; D007834:Lasers; D008954:Models, Biological; D019047:Phantoms, Imaging; D012879:Skin Physiological Phenomena; D014465:Ultrasonics