Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.
Serum (1-->3)-beta-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.
Wiederhold
Nathan P
NP
The University of Texas at Austin College of Pharmacy, Austin, Texas, USA. wiederholdn@uthscsa.edu
Najvar
Laura K
LK
Vallor
Ana C
AC
Kirkpatrick
William R
WR
Bocanegra
Rosie
R
Molina
Destiny
D
Olivo
Marcos
M
Graybill
John R
JR
Patterson
Thomas F
TF
D000818:Animals; D021461:Animals, Outbred Strains; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D015415:Biomarkers / Q000097:blood*; D004195:Disease Models, Animal; D006801:Humans; D008168:Lung / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D051379:Mice; D008813:Mice, Inbred ICR; D011509:Proteoglycans; D016896:Treatment Outcome; D047071:beta-Glucans / Q000097:blood*
D000935:Antifungal Agents; D015415:Biomarkers; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K