title: Gene expression profile and genomic changes in disease progression of early-stage chronic lymphocytic leukemia.
abstract: The biologic mechanisms involved in the clinical progression from early stages of patients with chronic lymphocytic leukemia (CLL) are not well known. We investigated sequential samples from 16 untreated CLL patients obtained at diagnosis in early stage and after progression before treatment. One patient had a p16 (INK4a) homozygous deletion at diagnosis and progression, and 3 patients acquired a p53 mutation, gains of 5q21-q23 and 11pter-p14, and a gain of chromosome 12 respectively, during the progression of the disease. Gene expression profile analysis showed a significant modulation of 58 genes with a particular downregulation of genes that are inhibitors of cell adhesion and motility.
authors.affiliation: Hematopathology Section, Department of Pathology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
authors.forename: Verònica
authors.initials: V
authors.lastname: Fernàndez
authors.forename: Pedro
authors.initials: P
authors.lastname: Jares
authors.forename: Itziar
authors.initials: I
authors.lastname: Salaverria
authors.forename: Eva
authors.initials: E
authors.lastname: Giné
authors.forename: Sílvia
authors.initials: S
authors.lastname: Beà
authors.forename: Marta
authors.initials: M
authors.lastname: Aymerich
authors.forename: Dolors
authors.initials: D
authors.lastname: Colomer
authors.forename: Neus
authors.initials: N
authors.lastname: Villamor
authors.forename: Francesc
authors.initials: F
authors.lastname: Bosch
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics; D016678:Genome; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16