Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats.
Wilson's disease is an inherited, autosomal recessive disorder of copper accumulation and toxicity. Lifelong chelation therapy is essential in all Wilson's disease patients. Intestinal absorption of some compounds is limited partly because they are preferentially transported in the secretory direction. Several ATP-binding cassette (ABC) transporters are expressed in the apical membrane of the small intestine and secrete various drugs into the lumen. In this study, we investigated the characteristics of the intestinal efflux ABC transporters in LEC rats. We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased.
Chiba
Makoto
M
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Itagaki
Shirou
S
Kobayashi
Masaki
M
Hirano
Takeshi
T
Iseki
Ken
K
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D015536:Down-Regulation; D006527:Hepatolenticular Degeneration / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000378:metabolism; D017035:Pravastatin / Q000378:metabolism; D011339:Probenecid / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D020332:Rats, Inbred LEC; D017208:Rats, Wistar; D013045:Species Specificity; D013448:Sulfobromophthalein / Q000494:pharmacology
D018528:ATP-Binding Cassette Transporters; C423013:Abcc2 protein, rat; D012333:RNA, Messenger; D013448:Sulfobromophthalein; D008353:Mannitol; D017035:Pravastatin; D011339:Probenecid