Association of serum RANTES concentrations with established cardiovascular risk markers in middle-aged subjects.
BACKGROUND
RANTES (regulated upon activation, normal T cells expressed and secreted) is known to be related to an inflammatory part of the atherosclerotic process. We investigated the association of serum concentrations of RANTES with the risk of coronary artery disease (CAD) in a case-control study.


METHODS
One hundred fifty one CAD male patients aged 40 to 65 years and 151 age-matched healthy male controls were included and the main outcome measure was the odds ratio (OR) for CAD associated with increased levels of RANTES.


RESULTS
Serum levels of RANTES were higher in CAD patients when compared with controls (47.1+/-1.57 ng/mL vs 37.3+/-1.48; P<0.001). In addition, values in the second and top tertile of RANTES were associated with an increased OR for CAD when compared with values in the bottom tertile; OR for RANTES top tertile was 2.86 (95% CI, 1.53 to 5.34) in the age- and WHR-adjusted model and 3.23 (95% CI, 1.02 to 10.3) after the fully adjustment. Furthermore, there was a positive correlation of serum RANTES with acute phase proteins such as hs-CRP (r=0.310, P<0.001) and fibrinogen (r=0.333, P<0.001). RANTES concentrations also displayed a moderate correlation of WHR, triglyceride, HDL-cholesterol, interleukin-1 beta, interleukin-6, adiponectin, platelet and white blood cell counts.


CONCLUSIONS
In the present study, RANTES is associated with CAD risk in middle-aged subjects.
Koh
Soo Jeong
SJ
Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea.
Kim
Ji Young
JY
Hyun
Yae Jung
YJ
Park
Soo Hyun
SH
Chae
Jey Sook
JS
Park
Sungha
S
Kim
Jung-Sun
JS
Youn
Jong Chan
JC
Jang
Yangsoo
Y
Lee
Jong Ho
JH
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001161:Arteriosclerosis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D049629:Waist-Hip Ratio
D015415:Biomarkers; D018946:Chemokine CCL5; D015850:Interleukin-6; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein