A countywide outbreak of pertussis: initial transmission in a high school weight room with subsequent substantial impact on adolescents and adults.
OBJECTIVE
To describe a large communitywide pertussis outbreak where aggressive diagnostic and treatment measures were used to control the outbreak.


METHODS
Retrospective analysis, May 2003 through February 2004.


METHODS
Fond du Lac County, Wisconsin (population 98,882).


METHODS
Health department personnel conducted case and contact investigations of suspected outbreak-associated illnesses using standard pertussis reporting forms and clinical evaluation and management protocols. Persons with compatible illness were tested for Bordetella pertussis using culture and for B pertussis DNA using polymerase chain reaction. Cases were classified using Council of State and Territorial Epidemiologists definitions.


METHODS
Health alerts and aggressive testing and treatment of suspected cases of pertussis illness and contact prophylaxis in the community.


METHODS
Incidences by age, onsets over time, and vaccine coverage in case patients.


RESULTS
We identified 261 pertussis cases among county residents; 149 (57%) were laboratory confirmed. Of the first 57 case patients, 47% reported using a particular high school weight room. Pertussis incidence was high in all age groups; 86% of case patients were 10 years or older. Among 156 case patients with reported vaccination histories, 84% had received 5 or more doses of pertussis-containing vaccine. Adults reported significantly more severe pertussis symptoms than adolescents.


CONCLUSIONS
Pertussis transmission among adolescents using a school weight room instigated a countywide outbreak with substantial incidence and morbidity among adolescents and adults. Aggressive testing and treatment in the outbreak response likely contributed to a sharp reduction in cases. This labor- and resource-intensive outbreak highlights potential benefits of pertussis booster vaccination among adolescent and adult populations.
Sotir
Mark J
MJ
Bureau of Communicable Diseases and Preparedness, Wisconsin Division of Public Health, Madison, Wisconsin 53702, USA.
Cappozzo
Dianne L
DL
Warshauer
David M
DM
Schmidt
Carol E
CE
Monson
Timothy A
TA
Berg
Jeffrey L
JL
Zastrow
Jean A
JA
Gabor
Gerald W
GW
Davis
Jeffrey P
JP
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001886:Bordetella pertussis / Q000235:genetics / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000453:epidemiology / Q000382:microbiology; D004269:DNA, Bacterial / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D017053:Infection Control / Q000458:organization & administration; D008297:Male; D008875:Middle Aged; D010567:Pertussis Vaccine / Q000008:administration & dosage; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology; D014611:Vaccination / Q000706:statistics & numerical data; D014839:Vomiting / Q000453:epidemiology / Q000382:microbiology; D014891:Weight Lifting; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D014922:Wisconsin / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010567:Pertussis Vaccine