title: Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
abstract: BACKGROUND
  It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated
  
  
  RESULTS
  A total of 186 consecutive male CAD patients participated in the study and were categorized into quartiles based on their total adiponectin level. The interquartile cut-off points were 4.0, 5.5 and 7.0 microg/ml. The HMW adiponectin levels were significantly lower in the quartile of lower total adiponectin levels both in non-diabetic and diabetic patients. In contrast, low molecular weight adiponectin levels (which were calculated as the Total - HMW) were constant. In univariate analysis, total adiponectin correlated negatively with body mass index and hemoglobin (Hb) A1c, and HMW adiponectin correlated negatively with HbA1c in non-diabetic patients. On the other hand, total and HMW adiponectin correlated positively with high-density lipoprotein-cholesterol (HDL-C) in diabetic patients. Multiple regression analysis revealed that HMW adiponectin correlated negatively with HbA1c in non-diabetic patients, and total and HMW adiponectin correlated positively with HDL-C in diabetic patients.
  
  
  CONCLUSIONS
  Change in the HMW isoform reflects a change in total adiponectin level. Measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in CAD patients.
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Komura
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Mina
authors.initials: M
authors.lastname: Sonoda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kumada
authors.forename: Koichi
authors.initials: K
authors.lastname: Fujita
authors.forename: Aki
authors.initials: A
authors.lastname: Hiuge
authors.forename: Takuya
authors.initials: T
authors.lastname: Okada
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tamba
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Hayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Sumitsuji
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Arita
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D050197:Atherosclerosis / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL; D003324:Coronary Artery Disease / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D006454:Hemoglobins