Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report.
BACKGROUND
Gonodoblastomas with ovarian germ cell tumors (OGCTs) other than dysgerminoma are very unusual. This is the first case report of a pure endodermal sinus tumor of the ovary with gonodoblastoma in a 46 XX, female.


METHODS
A 19-year-old female was admitted to our hospital with an abdominal mass and pain. She had elevated levels of CA-125 and AFP. Fertility sparing surgery was undertaken and revealed a Stage IA endodermal sinus tumor and gonodoblastoma in the same ovary. The patient refused chemotherapy and was followed-up for six months without disease.


CONCLUSIONS
Gonodoblastomas may occur in conjunction with OGCTs. Tumor markers and immunohistochemical examination may help in the diagnosis of these OGCTs with gonodoblastoma.
Erdemoglu
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Department of Obstetrics and Gynecology, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey.
Ozen
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D000328:Adult; D018240:Endodermal Sinus Tumor / Q000235:genetics* / Q000473:pathology; D005260:Female; D018238:Gonadoblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology