title: Dietary fat oxidation as a function of body fat.
abstract: BACKGROUND
  It is hypothesized that low dietary fat oxidation makes subjects prone to weight gain.
  
  
  OBJECTIVE
  The aim of the study was to determine dietary fat oxidation in normal, overweight, and obese subjects.
  
  
  METHODS
  The subjects were 38 women and 18 men with a mean (+/-SD) age of 30+/-12 y and a body mass index (in kg/m2) of 25+/-4 (range: 18-39). Dietary fat oxidation was measured with deuterated palmitic acid, given simultaneously with breakfast, while the subjects were fed under controlled conditions in a respiration chamber. Body composition was measured by hydrodensitometry and deuterium dilution.
  
  
  RESULTS
  Dietary fat oxidation, measured over 12 h after breakfast, ranged from 4% to 28% with a mean (+/-SD) of 16+/-6%. Dietary fat oxidation was negatively related to percentage body fat, and lean subjects had the highest and obese subjects the lowest values (r=-0.65, P<0.001).
  
  
  CONCLUSIONS
  The observed reduction in dietary fat oxidation in subjects with a higher percentage body fat may play a role in human obesity.
authors.affiliation: Department of Human Biology, Maastricht University, Maastricht, Netherlands. k.westerterp@hb.unimaas.nl
authors.forename: Klaas R
authors.initials: KR
authors.lastname: Westerterp
authors.forename: Astrid
authors.initials: A
authors.lastname: Smeets
authors.forename: Manuela P
authors.initials: MP
authors.lastname: Lejeune
authors.forename: Mirjam P E
authors.initials: MP
authors.lastname: Wouters-Adriaens
authors.forename: Margriet S
authors.initials: MS
authors.lastname: Westerterp-Plantenga
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D003903:Deuterium; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D050177:Overweight / Q000209:etiology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D019308:Palmitic Acid / Q000378:metabolism; D013851:Thinness / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D019308:Palmitic Acid; D003903:Deuterium