Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.
IL-17 is the defining cytokine of a newly-described "Th17" population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its function or molecular biology. However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here.
Shen
Fang
F
Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
Gaffen
Sarah L
SL
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D016723:Bone Remodeling / Q000502:physiology; D022762:CCAAT-Enhancer-Binding Proteins / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D017434:Protein Structure, Tertiary; D053722:Receptors, Interleukin-17 / Q000502:physiology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D000906:Antibodies; D022762:CCAAT-Enhancer-Binding Proteins; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D016328:NF-kappa B; D053722:Receptors, Interleukin-17; D014157:Transcription Factors