title: [Effect of short-term intensive treatment with insulin pump on beta cell function and the mechanism of oxidative stress in newly diagnosed type 2 diabetic patients].
abstract: OBJECTIVE
  To investigate the effect of short-term intensive treatment with insulin pump on beta cell function and the mechanism of oxidative stress in newly diagnosed type 2 diabetic patients.
  
  
  METHODS
  Totally 120 newly diagnosed type 2 diabetic patients were treated with insulin pump for 2 weeks. The levels of fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), homeostatic model assessment of the insulin secretion index and insulin resistance index (HOMA-beta and HOMAIR, respectively), blood malondialdehyde (MDA) and superoxide dismutase (SOD) were measured before and after insulin pump treatment.
  
  
  RESULTS
  After insulin pump treatment, FPG, 2hPG, HOMAIR and blood MDA were significantly decreased (P<0.01), while HOMA-beta and blood SOD were significantly increased (P<0.01).
  
  
  CONCLUSIONS
  Short-term intensive treatment with insulin pump can effectively improve beta cell function probably by decreasing oxidative stress in newly diagnosed type 2 diabetic patients.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. zhaoqingbin05@163.com
authors.forename: Qing-bin
authors.initials: QB
authors.lastname: Zhao
authors.forename: Hui-fang
authors.initials: HF
authors.lastname: Wang
authors.forename: Chao-feng
authors.initials: CF
authors.lastname: Sun
authors.forename: Ai-qun
authors.initials: AQ
authors.lastname: Ma
authors.forename: Chang-cong
authors.initials: CC
authors.lastname: Cui
mesh_terms: D000328:Adult; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007332:Insulin Infusion Systems; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008315:Malondialdehyde; D013482:Superoxide Dismutase