title: [Pharmacotherapy for social phobia, generalised anxiety disorder and separation anxiety disorder in children and adolescents: an overview].
abstract: BACKGROUND
  Anxiety disorders are among the most prevalent psychiatric disorders during childhood. They are often persistent and are associated with a number of negative outcomes. Therefore, effective treatment is required.
  
  
  OBJECTIVE
  To present an overview of placebo-controlled studies of pharmacotherapy for social phobia, generalised anxiety disorder and separation anxiety disorder in children an adolescents and to determine which medication is the most effective.
  
  
  METHODS
  The literature was reviewed using Pubmed.
  
  
  RESULTS
  Nine randomised double-blind studies on the efficacy of pharmacotherapy for generalised anxiety disorder, separation anxiety disorder and social phobia were found. Tricyclic antidepressants were not more effective than placebo. Studies on benzodiazepines showed that the effect of these drugs was not superior to that of placebo either. Studies of the efficacy of ssris, however, proved that they were superior to placebo.
  
  
  CONCLUSIONS
  SSRIS are the drugs of first choice for the treatment of social phobias, separation anxiety disorder and generalised anxiety disorder in children and adolescents. There is strong evidence that ssris are effective for the treatment of these anxiety disorders; the standardised effect size varies between medium and large.
authors.affiliation: Polikliniek voor Kinder- en, Jeugdpsychiatrie, Erasmus Medisch Centrum/Sophia Kinderziekenhuis, Dr. Molewaterplein 60, 3015 GJ Rotterdam. g.dieleman@erasmusmc.nl
authors.forename: G C
authors.initials: GC
authors.lastname: Dieleman
authors.forename: R F
authors.initials: RF
authors.lastname: Ferdinand
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy*; D001010:Anxiety, Separation / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors