title: Adenocarcinoma of Ethmoid: a GETTEC retrospective multicenter study of 418 cases.
abstract: OBJECTIVE
  To determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. Epidemiologic data were recorded and compared with the literature.
  
  
  METHODS
  A multicenter and retrospective study. The medical records of 418 patients who had presented with ethmoid adenocarcinoma at 11 French hospitals from 1976 to 2001 were analyzed to determine the clinical characteristics and treatment of the disease.
  
  
  RESULTS
  The gender ratio was 2.8 men per 1 woman. Toxic exposure was classic for this lesion, exposure to wood and leather for most cases. The mean age was 63 years (range 31-91). Symptoms were nonspecific and based on clinical rhinologic signs. Nasal endoscopy after mucosal retraction was found useful to evaluate the extension of the lesion and to perform biopsies. Computed tomography scan and magnetic resonance imagery must be carried out prior to treatment to define extra nasal extension. The survival rate was significantly influenced by the size of the lesion (T4, N+) and extension to brain or dura. Surgery with postoperative radiotherapy remains the treatment of choice. Total excision must be a major priority, as confirmed in our series.
  
  
  CONCLUSIONS
  This retrospective study was, to our knowledge, the largest ever reported in the literature. This series confirmed the risk factor of this lesion as well as the lesion's influence on the survival rate. Surgery is the most important part of the treatment. Local recurrences were responsible for the poor prognosis of this lesion.
authors.affiliation: ENT department, Rouen University Hospital, Rouen, France. olivier.choussy@chu-rouen.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Choussy
authors.forename: Christophe
authors.initials: C
authors.lastname: Ferron
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Védrine
authors.forename: Bruno
authors.initials: B
authors.lastname: Toussaint
authors.forename: Béatrice
authors.initials: B
authors.lastname: Liétin
authors.forename: Patrick
authors.initials: P
authors.lastname: Marandas
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Babin
authors.forename: Dominique
authors.initials: D
authors.lastname: De Raucourt
authors.forename: Emile
authors.initials: E
authors.lastname: Reyt
authors.forename: Alain
authors.initials: A
authors.lastname: Cosmidis
authors.forename: Marc
authors.initials: M
authors.lastname: Makeiff
authors.forename: Danièle
authors.initials: D
authors.lastname: Dehesdin
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005005:Ethmoid Sinus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies