Epstein-Barr virus genotypes in multiple sclerosis.
BACKGROUND
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but the relationship between the virus and the disease is not clear. As many different types of EBV exist, it is possible that MS is caused by one particular type of EBV. Objectives - The aim of this study was to determine whether MS is associated with a particular genotype of EBV.


METHODS
We collected blood from MS patients and controls, amplified and sequenced the latent membrane protein-1 (LMP-1) gene, and compared the groups.


RESULTS
We found a variety of LMP-1 sequences in both MS and controls, with no significant differences between the groups. Conclusion - We conclude that MS is not associated with a particular genotype of EBV.
Lindsey
J W
JW
Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. john.w.lindsey@uth.tmc.edu
Patel
S
S
Zou
J
J
D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000235:genetics*; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000821:virology*; D014763:Viral Matrix Proteins / Q000235:genetics
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins