title: Effect of a Growth Protein-Colostrum Fraction on bone development in juvenile rats.
abstract: Colostrum is a complex mixture of bioactives that promotes neonate growth. Studies show that it contains components capable of promoting bone formation and inhibiting bone resorption. Although many colostrum-based nutritional supplements have been developed as growth promotants, few studies have investigated their functional effects. A bovine colostrum 1-30 kDa fraction, Growth Protein-Colostrum (GP-C), was administered to juvenile rats as a dietary supplement to determine effects on growth and development. GP-C enhanced the growth and mineralization of the femur as evidenced by increased serum osteocalcin and bone mineral density. Increased levels of serum growth hormone and insulin-like growth factor-1 suggest that the mechanism of enhanced growth is partially controlled by endocrine factors. GP-C was also found to increase osteoblast proliferation in vitro, a finding that indicates a possible mechanism of action of GP-C, but further studies are required. Based on our findings, we hypothesize that a colostrum-based dietary supplement enhances bone growth and development in humans.
authors.affiliation: RexGene Biotech Co., Ltd., Korea.
authors.forename: Jeongrai
authors.initials: J
authors.lastname: Lee
authors.forename: Suk-Hyung
authors.initials: SH
authors.lastname: Kwon
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kim
authors.forename: Stefan N
authors.initials: SN
authors.lastname: Fahey
authors.forename: Derek R
authors.initials: DR
authors.lastname: Knighton
authors.forename: Andrew
authors.initials: A
authors.lastname: Sansom
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D015519:Bone Density; D001846:Bone Development / Q000502:physiology*; D002417:Cattle; D003126:Colostrum / Q000502:physiology*; D019587:Dietary Supplements; D019382:Human Growth Hormone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008894:Milk Proteins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008894:Milk Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I