Histology far away from Flatland: 3D roller-coasting into grade-dependent angiogenetic patterns in oligodendrogliomas.
Angiogenesis plays a key role in tumour progression, and undergoes structural changes associated to tumour biology itself. Although vessel density can be easily evaluated in brain tumours using a traditional immuno-histochemical approach, other parameters of conceptual/biological interest, such as the complex patterns of vascular growth, cannot be fully understood using a traditional bi-dimensional evaluation. We use here surgical specimens derived from oligodendrogliomas as a model for a novel elucidative 3D reconstruction of the grade-dependent vascular arborisation in brain tumours.
Cassoni
P
P
Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
Gaetano
L
L
Senetta
R
R
Bussolati
B
B
Molinaro
L
L
Bussolati
G
G
D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009837:Oligodendroglioma / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery