title: Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions.
abstract: In the current issue of Cancer Cell, Hallstrom et al. show that a subset of targets of the growth regulatory transcription factor E2F1 are repressed by a serum-induced PI3K activation, explaining how apoptosis can be suppressed while simultaneously engaging a proliferation program.
authors.affiliation: Department of Pathology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA. brian.dynlacht@med.nyu.edu
authors.forename: Brian David
authors.initials: BD
authors.lastname: Dynlacht
mesh_terms: D055372:AMP-Activated Protein Kinases; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D012265:Ribonucleotides / Q000494:pharmacology
chemical_list: D055372:AMP-Activated Protein Kinases; D000620:Aminoimidazole Carboxamide; D050687:E2F1 Transcription Factor; D009097:Multienzyme Complexes; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D012265:Ribonucleotides; C031143:AICA ribonucleotide