title: Van der Woude syndrome: clinical presentation in 64 patients.
abstract: OBJECTIVE
  Van der Woude syndrome, characterized by lip pits and cleft lip/ palate, presents with variable expressions. This retrospective study was designed to obtain a better understanding of its clinical pattern in Taiwanese patients.
  
  
  METHODS
  Of 13,147 cleft patients treated at the Chang Gung Craniofacial Center from 1976 to 2004, there were 64 with Van der Woude syndrome. Clinical expressions and family histories were collected and analyzed.
  
  
  RESULTS
  The male to female ratio was 1:1. The majority had complete cleft types. Severe cleft was found among the patients, with 52% having bilateral cleft lip and palate, 31% having unilateral cleft lip and palate, and 17% having isolated cleft palate. A positive family history was found in 53.1% of the patients. The size, shape, location, and depth of the pits varied among patients.
  
  
  CONCLUSIONS
  Clinical presentations did not always parallel those reported in the literatures. These differences warrant further investigation.
authors.affiliation: Craniofacial Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jung-Ju
authors.initials: JJ
authors.lastname: Huang
authors.forename: Jia-Woei
authors.initials: JW
authors.lastname: Hou
authors.forename: Ying-Chien
authors.initials: YC
authors.lastname: Tan
authors.forename: Kuo-Ting
authors.initials: KT
authors.lastname: Chen
authors.forename: Lun-Jou
authors.initials: LJ
authors.lastname: Lo
authors.forename: Yu-Ray
authors.initials: YR
authors.lastname: Chen
mesh_terms: D000015:Abnormalities, Multiple; D002971:Cleft Lip / Q000235:genetics / Q000473:pathology*; D002972:Cleft Palate / Q000235:genetics / Q000473:pathology*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree; D019683:Penetrance; D012189:Retrospective Studies; D012744:Sex Ratio; D013577:Syndrome; D013624:Taiwan