The treatment of movement disorders by deep brain stimulation.
It has been understood, for some time, that modulation of deep brain nuclei within the basal ganglia and thalamus can have a therapeutic effect in patients with movement disorders. Because of its reversibility and adjustability, deep brain stimulation (DBS) has largely come to replace traditional ablation procedures. The clinical effects of DBS vary, depending both on the target being stimulated and on the parameters of stimulation. Both aspects are currently the subject of substantial research and discovery. The most common targets for DBS treatment include the subthalamic nucleus for the treatment of advanced Parkinson's disease, the ventral intermediate nucleus of the thalamus for the treatment of medically refractory essential tremor, and the globus pallidus interna for the treatment of both cervical and generalized dystonias and Parkinson's disease. We review the current indications, targets, outcomes, and general procedure of DBS for essential tremor, Parkinson's disease, and dystonia.
Yu
Hong
H
Department of Neurological Surgery, Vanderbilt University, Nashville, Tennessee 37232, USA.
Neimat
Joseph S
JS
D001921:Brain / Q000503:physiopathology / Q000528:radiation effects*; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000473:pathology / Q000628:therapy*; D020329:Essential Tremor / Q000473:pathology / Q000628:therapy; D006801:Humans; D009069:Movement Disorders / Q000473:pathology / Q000628:therapy*; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy