title: Bleomycin, etoposide and cisplatin (BEP) combination with concurrent imatinib mesylate (GLEEVEC) in chronic myeloid leukemia (CML) patient with mesenchymal tumor.
abstract: Imatinib is now indicated as the first line therapy for chronic myeloid leukemia (CML). Treatment of CML with imatinib is generally well tolerated and the risk of severe adverse affects is low. Many new drugs including targeted therapy are combined with antineoplastic agents safely. We here report a patient with CML who developed concurrent mesenchymal tumor while undergoing therapy with imatinib and treated with combination chemotherapy including bleomycin, etoposide, and cisplatin, as well as imatinib without severe toxicity.
authors.affiliation: Medical Faculty, Department of Medical Oncology, Süleyman Demirel University, Isparta, 32040, Turkey. hscoskun@yahoo.com
authors.forename: Hasan Senol
authors.initials: HS
authors.lastname: Coşkun
authors.forename: Sema Sezgin
authors.initials: SS
authors.lastname: Göksu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sahin
authors.forename: Güçhan
authors.initials: G
authors.lastname: Alanoğlu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008637:Mesenchymoma / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D001761:Bleomycin; D005047:Etoposide; D000068877:Imatinib Mesylate; D002945:Cisplatin