Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.
Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs.
Suhara
Yoshitomo
Y
Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Hirota
Yoshihisa
Y
Nakagawa
Kimie
K
Kamao
Maya
M
Tsugawa
Naoko
N
Okano
Toshio
T
D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D013329:Structure-Activity Relationship; D024482:Vitamin K 2 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D024482:Vitamin K 2