Subacute toxicity of colistin methanesulfonate in rats: comparison of various intravenous dosage regimens.
The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.
Wallace
Stephanie J
SJ
Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Li
Jian
J
Nation
Roger L
RL
Rayner
Craig R
CR
Taylor
David
D
Middleton
Deborah
D
Milne
Robert W
RW
Coulthard
Kingsley
K
Turnidge
John D
JD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001522:Behavior, Animal / Q000187:drug effects; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced; D008698:Mesylates / Q000008:administration & dosage / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D008698:Mesylates; C045880:methanesulfonic acid; D003091:Colistin