PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.
Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P approximately PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD-PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P approximately PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.
Gong
Wuming
W
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Zhou
Dihan
D
Ren
Yongliang
Y
Wang
Yejun
Y
Zuo
Zhixiang
Z
Shen
Yanping
Y
Xiao
Feifei
F
Zhu
Qi
Q
Hong
Ailing
A
Zhou
Xiaochuan
X
Gao
Xiaolian
X
Li
Tongbin
T
D001665:Binding Sites; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping; D014584:User-Computer Interface
D010750:Phosphoproteins