Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides.
A linkage-based genome scan of 1,258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
Williams-Blangero
Sarah
S
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA. sarah@sfbrgenetics.org
Vandeberg
John L
JL
Subedi
Janardan
J
Jha
Bharat
B
Corrêa-Oliveira
Rodrigo
R
Blangero
John
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001196:Ascariasis / Q000208:ethnology / Q000235:genetics*; D017164:Ascaris lumbricoides / Q000472:pathogenicity*; D002648:Child; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006790:Host-Parasite Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009390:Nepal; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable