title: A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
abstract: A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Dexuan
authors.initials: D
authors.lastname: Xiang
authors.forename: Kewei
authors.initials: K
authors.lastname: Wang
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Liang
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Zhou
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D011728:Pyridones