Genomics of reproduction in nematodes: prospects for parasite intervention?
Understanding reproductive processes in parasitic nematodes has the potential to lead to the informed design of new anthelmintics and control strategies. Little is known, however, about the molecular mechanisms underlying sex determination, gametogenesis and reproductive physiology for most parasitic nematodes. Together with comparative analyses of data for the free-living nematode Caenorhabditis elegans, molecular investigations are beginning to provide insights into the processes involved in reproduction and development in parasitic nematodes. Here, we review recent developments, focusing on technological aspects and on molecules associated with sex-specific differences in adult nematodes.
Nisbet
Alasdair J
AJ
Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK. Alasdair.Nisbet@moredun.ac.uk
Cottee
Pauline A
PA
Gasser
Robin B
RB
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D019295:Computational Biology; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D023281:Genomics / Q000379:methods; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008954:Models, Biological; D009348:Nematoda / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D012098:Reproduction / Q000235:genetics* / Q000502:physiology; D019849:Sex Determination Processes; D012733:Sex Differentiation
D015801:Helminth Proteins