Cardiac functions in children with coeliac disease during follow-up: insights from tissue Doppler imaging.
BACKGROUND
The identification of a coeliac disease in patients with idiopathic dilated cardiomyopathy raises critical questions on the relationship between the two entities. But cardiac functions have not been studied in patients with coeliac disease. The present study was undertaken to assess cardiac functions by Tissue Doppler Echocardiography in patient with coeliac disease.


METHODS
We studied 45 clinically stable patients; twenty-five patients with positive serum IgA Antiendomysial Antibody levels (Group 1), twenty patients with negative serum IgA Antiendomysial Antibody levels (Group 2) at the time of echocardiographic study. Control group consisted of 30 healthy children free of any disease.


RESULTS
Myocardial systolic wave velocity of the mitral annulus was significantly lower (p<0.001), myocardial precontraction and contraction time were slightly longer in Group 2 when compared control group (p=0.015, p=0.044, respectively). There was a negative correlation between the serum IgA Antiendomysial Antibody levels titers and myocardial systolic wave levels of all patients included in the study (r = -0.633; p<0.001). A myocardial systolic wave velocity of <8.9 cm/s had a 92% sensitivity and 80% specificity in predicting serum IgA Antiendomysial Antibody levels positive patients.


CONCLUSIONS
We detected subclinical systolic dysfunction of the left ventricle in children with coeliac disease in whom serum IgA Antiendomysial Antibody reactivity is prominent. Tissue Doppler echocardiography provides a quantifiable indicator useful for cardiac monitoring of disease during follow up.
Polat
Tugcin B
TB
Department of Pediatric Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, 5 Gazeteciler sitesi A1 Blok 3 nolu villa, Akatlar-Istanbul, Istanbul, Turkey. tugcin75@mynet.com
Urganci
Nafiye
N
Yalcin
Yalim
Y
Zeybek
Cenap
C
Akdeniz
Celal
C
Erdem
Abdullah
A
Imanov
Elnur
E
Celebi
Ahmet
A
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D016275:Atrial Function / Q000502:physiology*; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D002446:Celiac Disease / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D011379:Prognosis; D013997:Time Factors; D016276:Ventricular Function / Q000502:physiology*
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A