[Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis].
OBJECTIVE
We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis.


METHODS
The study included 40 patients (13 males, 27 females; mean age 30+/-14 years; range 4 to 63 years) with allergic rhinitis. The mean symptom duration was 5.2+/-4.9 years. Blood and serum samples were analyzed spectrophotometrically. Myeloperoxidase (MPO) activity and vitamins A and E were measured as enzymatic and non-enzymatic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde (MDA) level. Total antioxidant capacity (TAC) was measured as the total antioxidant activity against oxidative stress products. The results were compared with those of a control group consisting of 40 healthy individuals.


RESULTS
Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were significantly lower in the patient group (p<0.05).


CONCLUSIONS
Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.
Akbay
Ercan
E
Department of Otolaryngology, Bingöl State Hospital, Bingöl, Turkey. ercanakbay@yahoo.com
Arbağ
Hamdi
H
Uyar
Yavuz
Y
Oztürk
Kayhan
K
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D009195:Peroxidase