A case of more abundant and dysplastic adenomas in the interposed colon than in the native colon.
We report a 60-year-old woman with intramucosal adenocarcinoma arising in the interposed colon, 40 years after the esophageal reconstruction for lye induced esophageal stricture. Although synchronous adenomas were also found in the native colon where the graft was taken, the number of adenomas was greater in the interposed colon and more dysplastic, even progressed to adenocarcinoma, than that of the native colon. The microsatellite instability-testing performed in the intramucosal carcinoma from interposed colon showed absence of microsatellite instability. Changing of location and functional demand of colonic segment, and the exposure to different intraluminal contents might have facilitated the adenoma- carcinoma transformation in the interposed colon.
Hwang
Hye Jin
HJ
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
Song
Kyung Ho
KH
Youn
Young Hoon
YH
Kwon
Ji Eun
JE
Kim
Hoguen
H
Chung
Jae Bock
JB
Lee
Yong Chan
YC
D000230:Adenocarcinoma / Q000473:pathology; D000236:Adenoma / Q000209:etiology / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology*; D018450:Disease Progression; D004944:Esophagoplasty / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D013997:Time Factors