title: Serum selenium, vitamin E, and sialic acids concentrations in lambs with white muscle disease.
abstract: The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, University of Yuzuncu Yil, 65080, Van, Turkey. ydeger65@hotmail.com
authors.forename: Yeter
authors.initials: Y
authors.lastname: Değer
authors.forename: Handan
authors.initials: H
authors.lastname: Mert
authors.forename: Nihat
authors.initials: N
authors.lastname: Mert
authors.forename: Fatmagül
authors.initials: F
authors.lastname: Yur
authors.forename: Süleyman
authors.initials: S
authors.lastname: Kozat
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Yörük
authors.forename: Tevhide
authors.initials: T
authors.lastname: Sel
mesh_terms: D000818:Animals; D008055:Lipids / Q000097:blood; D012643:Selenium / Q000097:blood*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*; D012794:Sialic Acids / Q000097:blood*; D018038:Sodium Selenite / Q000627:therapeutic use; D014810:Vitamin E / Q000097:blood* / Q000627:therapeutic use; D014912:White Muscle Disease / Q000097:blood* / Q000188:drug therapy
chemical_list: D008055:Lipids; D012794:Sialic Acids; D014810:Vitamin E; D012643:Selenium; D018038:Sodium Selenite