European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II.
OBJECTIVE
The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands.


METHODS
Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update.


RESULTS
The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities.


CONCLUSIONS
Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.
Krege
Susanne
S
Department of Urology, Krankenhaus Maria-Hilf, Krefeld, Germany.
Beyer
Jörg
J
Souchon
Rainer
R
Albers
Peter
P
Albrecht
Walter
W
Algaba
Ferran
F
Bamberg
Michael
M
Bodrogi
István
I
Bokemeyer
Carsten
C
Cavallin-Ståhl
Eva
E
Classen
Johannes
J
Clemm
Christoph
C
Cohn-Cedermark
Gabriella
G
Culine
Stéphane
S
Daugaard
Gedske
G
De Mulder
Pieter H M
PH
De Santis
Maria
M
de Wit
Maike
M
de Wit
Ronald
R
Derigs
Hans Günter
HG
Dieckmann
Klaus-Peter
KP
Dieing
Annette
A
Droz
Jean-Pierre
JP
Fenner
Martin
M
Fizazi
Karim
K
Flechon
Aude
A
Fosså
Sophie D
SD
del Muro
Xavier Garcia
XG
Gauler
Thomas
T
Geczi
Lajos
L
Gerl
Arthur
A
Germa-Lluch
Jose Ramon
JR
Gillessen
Silke
S
Hartmann
Jörg T
JT
Hartmann
Michael
M
Heidenreich
Axel
A
Hoeltl
Wolfgang
W
Horwich
Alan
A
Huddart
Robert
R
Jewett
Michael
M
Joffe
Johnathan
J
Jones
William G
WG
Kisbenedek
László
L
Klepp
Olbjørn
O
Kliesch
Sabine
S
Koehrmann
Kai Uwe
KU
Kollmannsberger
Christian
C
Kuczyk
Markus
M
Laguna
Pilar
P
Galvis
Oscar Leiva
OL
Loy
Volker
V
Mason
Malcolm D
MD
Mead
Graham M
GM
Mueller
Rolf
R
Nichols
Craig
C
Nicolai
Nicola
N
Oliver
Tim
T
Ondrus
Dalibor
D
Oosterhof
Gosse O N
GO
Paz-Ares
Luis
L
Pizzocaro
Giorgio
G
Pont
Jörg
J
Pottek
Tobias
T
Powles
Tom
T
Rick
Oliver
O
Rosti
Giovanni
G
Salvioni
Roberto
R
Scheiderbauer
Jutta
J
Schmelz
Hans-Ulrich
HU
Schmidberger
Heinz
H
Schmoll
Hans-Joachim
HJ
Schrader
Mark
M
Sedlmayer
Felix
F
Skakkebaek
Niels E
NE
Sohaib
Aslam
A
Tjulandin
Sergei
S
Warde
Padraig
P
Weinknecht
Stefan
S
Weissbach
Lothar
L
Wittekind
Christian
C
Winter
Eva
E
Wood
Lori
L
von der Maase
Hans
H
D001706:Biopsy; D003131:Combined Modality Therapy / Q000379:methods / Q000592:standards; D032921:Consensus; D003245:Consensus Statements as Topic; D005060:Europe; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods / Q000592:standards; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012955:Societies, Medical; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000628:therapy*