title: Stent thrombosis in real-world patients: a comparison of drug-eluting with bare metal stents.
abstract: BACKGROUND
  Although the introduction of drugeluting stents (DES) has been associated with an impressive reduction in target vessel revascularisation, there has been concern about the safety profile. The aim of this study was to determine the incidence of stent thrombosis in real-world patients and evaluate the contribution of drug-eluting stents.
  
  
  METHODS
  A prospective observational cohort study was conducted at a high-volume centre in Utrecht, the Netherlands. All patients who underwent a percutaneous coronary intervention (PCI) between 1 January and 31 December 2005 were evaluated. The patients were pretreated with aspirin and clopidogrel, which was continued for six months in bare metal stents (BMS) and 12 months in DES.
  
  
  RESULTS
  In 2005, 1309 patients underwent a percutaneous coronary intervention procedure with stent implantation. After a median follow-up of nine months, 1.8% (n=23) of the patients had suffered from stent thrombosis. Two cases could be attributed to incorrect use of antiplatelet agents. In 8/23 cases, a technical reason was found such as an unrecognised dissection or stent underexpansion. The timing of stent thrombosis was acute in 1/23 patients, subacute in 20/23 patients and late in 2/23 patients. In both cases of late stent thrombosis, a BMS had been used. There were no differences in stent thrombosis rates between DES and BMS (1.4 vs. 1.9%, ns.). This is remarkable since DES were used in more complex and longer lesions.
  
  
  CONCLUSIONS
  The use of DES in routine daily practice does not appear to be associated with a higher rate of stent thrombosis than BMS. (Neth Heart J 2007;15:382-6.Neth Heart J 2007;15:382-6).
authors.affiliation: Medical Spectrum Twente, the Netherlands.
authors.forename: F H
authors.initials: FH
authors.lastname: de Man
authors.forename: P R
authors.initials: PR
authors.lastname: Stella
authors.forename: H
authors.initials: H
authors.lastname: Nathoe
authors.forename: H
authors.initials: H
authors.lastname: Kirkels
authors.forename: B
authors.initials: B
authors.lastname: Hamer
authors.forename: H W
authors.initials: HW
authors.lastname: Meijburg
authors.forename: P A
authors.initials: PA
authors.lastname: Doevendans