Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?
Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).
Kölbel
Tilo
T
Department of Vascular Diseases, Malmö University Hospital, Sweden. tilo.kolbel@skane.se
Strandberg
Karin
K
Donath
Tobias
T
Mattiasson
Ingrid
I
Stenflo
Johan
J
Lindblad
Bengt
B
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D018046:Protein C Inhibitor / Q000097:blood*; D012720:Severity of Illness Index; D013917:Thrombin / Q000378:metabolism*
D015415:Biomarkers; D011486:Protein C; D018046:Protein C Inhibitor; D013917:Thrombin