title: Elevated levels of prothrombin fragment 1 + 2 indicate high risk of thrombosis.
abstract: Prothrombin fragment 1 + 2 (F1 + 2) is considered to be useful for diagnosis of thrombosis. However, the evidence for a diagnosis of thrombosis by F1 + 2 is still not well established. The plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were measured in 694 patients suspected of having thrombosis and then were correlated with thrombosis. Plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were significantly higher in patients with thrombosis, compared with patients without thrombosis. When cutoff values of more than 300 pmol/L for F1 + 2 were used for the diagnosis, more than 50% of the patients were thus found to have thrombosis. The findings showed that F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex have similar diagnostic ability. The plasma concentration of F1 + 2 closely was well correlated with thrombin-antithrombin complex, soluble fibrin, and D-dimer. Finally, F1 + 2 is one of the most useful parameters for the diagnosis of thrombosis.
authors.affiliation: Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Mie-ken, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Abe
authors.forename: Eri
authors.initials: E
authors.lastname: Yamada
authors.forename: Akane
authors.initials: A
authors.lastname: Sakaguchi
authors.forename: Junji
authors.initials: J
authors.lastname: Nishioka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hatada
authors.forename: Ken
authors.initials: K
authors.lastname: Ishikura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sudo
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III; D016022:Case-Control Studies; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010447:Peptide Hydrolases / Q000097:blood; D011516:Prothrombin; D012307:Risk Factors; D012995:Solubility; D013927:Thrombosis / Q000097:blood* / Q000175:diagnosis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; D000990:Antithrombin III; D011516:Prothrombin; D005337:Fibrin; D010447:Peptide Hydrolases