Modulation of apoptosis to reverse chemoresistance.
Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.
Mor
Gil
G
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Montagna
Michele K
MK
Alvero
Ayesha B
AB
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D017024:Chemotherapy, Adjuvant; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics
D000970:Antineoplastic Agents; D051034:Inhibitor of Apoptosis Proteins; D007529:Isoflavones; D051636:X-Linked Inhibitor of Apoptosis Protein; C471183:phenoxodiol