[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].
OBJECTIVE
To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.


METHODS
The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.


RESULTS
Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.


CONCLUSIONS
HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.
Cai
Hong
H
Department of Laser Medicine, Chinese PLA Hospital, Beijing, China.
Gu
Ying
Y
Zeng
Jing
J
Li
Shao-ran
SR
Wang
Ying
Y
Shi
Dong-wen
DW
Zhang
Lu-yong
LY
D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000628:therapy*; D004423:Ear / Q000473:pathology; D005260:Female; D006415:Hematoporphyrins / Q000494:pharmacology*; D008297:Male; D010778:Photochemotherapy; D011817:Rabbits
D006415:Hematoporphyrins; C494379:hematoporphyrin monomethyl ether