title: Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma.
abstract: A 72-year-old man presented with erythema and induration of his calves and forearms. He had a past history of stage 1 colorectal carcinoma, treated with resection and primary anastamosis 4 years earlier. A diagnosis of eosinophilic fasciitis was made based on the characteristic clinical appearance, peripheral blood eosinophilia and a skin biopsy. There was no improvement in the condition following treatment with prednisolone or methotrexate. One year later, abnormal liver function studies were noted, and an abdominal computed tomography scan and subsequent needle biopsy of the liver confirmed a neoplastic lesion in the liver consistent with a metastatic colorectal carcinoma. Systemic chemotherapy with oxaliplatin, 5-fluorouracil and capecitabine was commenced, and resulted in partial remission of the colorectal carcinoma. Simultaneously, the indurations of the forearms and calves also improved, suggesting that the eosinophilic fasciitis was a paraneoplastic phenomenon.
authors.affiliation: Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, SA, Australia.
authors.forename: Hamish
authors.initials: H
authors.lastname: Philpott
authors.forename: Pravin
authors.initials: P
authors.lastname: Hissaria
authors.forename: Lachlan
authors.initials: L
authors.lastname: Warrren
authors.forename: Nimit
authors.initials: N
authors.lastname: Singhal
authors.forename: Michael
authors.initials: M
authors.lastname: Brown
authors.forename: Susanna
authors.initials: S
authors.lastname: Proudman
authors.forename: Les
authors.initials: L
authors.lastname: Cleland
authors.forename: David
authors.initials: D
authors.lastname: Gillis
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D005208:Fasciitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000556:secondary; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000473:pathology