title: [Synthesis and antiviral activity of lupane triterpenoids with modified cycle E].
abstract: A reductive transformation of the peroxide products of ozonolysis of derivatives of 3beta-O-acetyl-22(17-->28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex.
authors.forename: O B
authors.initials: OB
authors.lastname: Flekhter
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: O S
authors.initials: OS
authors.lastname: Kukovinets
authors.forename: L V
authors.initials: LV
authors.lastname: Spirikhin
authors.forename: E G
authors.initials: EG
authors.lastname: Galkin
authors.forename: F Z
authors.initials: FZ
authors.lastname: Galin
authors.forename: D G
authors.initials: DG
authors.lastname: Golovanov
authors.forename: N I
authors.initials: NI
authors.lastname: Pavlova
authors.forename: O V
authors.initials: OV
authors.lastname: Savinova
authors.forename: E I
authors.initials: EI
authors.lastname: Boreko
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002384:Catalysis; D006801:Humans; D029521:Alphainfluenzavirus / Q000187:drug effects*; D017975:Ruthenium Compounds / Q000737:chemistry; D012503:Saponins / Q000737:chemistry; D018139:Simplexvirus / Q000187:drug effects*; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
chemical_list: D000998:Antiviral Agents; D017975:Ruthenium Compounds; D012503:Saponins; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes; C027646:ruthenium tetraoxide