Malignant transformation of multiple familial trichoepithelioma: case report and literature review.
Patients with the autosomal-dominant form of multiple familial trichoepithelioma develop numerous tumours on the face, neck and upper trunk, beginning in childhood. Malignant transformation of such lesions is quite rare; only one case of "malignant trichoepithelioma" has been reported previously, inferring pilomatrix carcinoma on a histological observation. We report here the case of a patient who developed a malignant neoplasm in a long-standing trichoepithelioma lesion on her buttock. Histopathology revealed a transformation zone between the trichoepithelioma and a malignant tumour mass. This case also showed several features of a malignant neoplasm of trichoblastic origin.
Lee
Kyung Ho
KH
Department of Dermatology, College of Medicine, The Catholic University of Korea, 2 Sosa-Dong, Wonmi-Gu, Pucheon-Si, Kyunggi-Do, Korea.
Kim
Jung Eun
JE
Cho
Baik Kee
BK
Kim
Yu Chan
YC
Park
Chul Jong
CJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018280:Carcinoma, Skin Appendage / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*