[Mechanism of the cancerogenesis in cervix paraepidermal epithelium cells with chronic infection of oncogenic types of human papiloma virus].
The human papillomavirus family is composed of a large number of different and variably related types, each of which is associated with a characteristic set of epithelial lesions. Each of the many identified types of human papillomavirus have shown considerable specificity of different anatomical sites and different characteristic lesions. HPV 6 and 11 are frequently associated with benign condylomas, while HPV 16 and 18 are associated with malignant progression and cervical cancer. The genome of papillomaviruses is composed of a circular double stranded DNA. Various open reading frames (ORFs) are located on only one DNA strand. The coding strand contains from 8 to 10 translational ORFs. Among them, only 6 to 8 were designated as early and 2 as late. The role of HPVs 16 and 18 in uterine cervix carcinoma has been well-documented, but their contriobution to carcinogenesis of other neoplasias is still questionable.
Kedzia
Witold
W
Klinika Onkologii Ginekologicznej Katedry Ginekologii i Połoznictwa Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu. witold.kedzia@poczta.fm
Goździcka-Józefiak
Anna
A
D002471:Cell Transformation, Neoplastic; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D052140:Human papillomavirus 11 / Q000235:genetics; D052162:Human papillomavirus 16 / Q000235:genetics; D052161:Human papillomavirus 18 / Q000235:genetics; D052163:Human papillomavirus 6 / Q000235:genetics; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D014412:Tumor Virus Infections / Q000235:genetics* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000821:virology; D016387:Women's Health; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology* / Q000821:virology