title: Calcification of Hydroview H60M intraocular lenses: aqueous humor analysis and comparisons with other intraocular lens materials.
abstract: OBJECTIVE
  To compare the level of calcification on Hydroview H60M hydrophilic acrylic intraocular lenses (IOLs) (Bausch & Lomb) and other IOL materials.
  
  
  METHODS
  Omori Medical Center, Department of Ophthalmology, Toho University, Tokyo, Japan.
  
  
  METHODS
  The levels of calcification on Hydroview H60M hydrophilic acrylic IOLs, AcrySof SA60AT hydrophobic acrylic IOLs (Alcon Surgical, Inc.), Sensar AR40e hydrophobic acrylic IOLs (Advanced Medical Optics), ClariFlex (Advanced Medical Optics) silicone IOLs, and the MeniFlex ENV13 (Menicon) poly(methyl methacrylate) IOLs were compared in a calcium phosphate solution containing albumin. In a concentration-change experiment, the calcium and phosphate concentration levels were changed and the results observed by scanning electron microscopy.
  
  
  RESULTS
  The Hydroview H60M IOL had the largest amount of deposits. Small amounts of deposits were found on the other IOLs in the following decreasing order: AcrySof SA60AT, Sensar AR40e, ClariFlex, and MeniFlex ENV13. The amount of deposits on the Hydroview H60M IOLs was statistically significantly greater than the amount on the other IOLs (P<.01).
  
  
  CONCLUSIONS
  The hydrophilic acrylic IOLs (Hydroview H60M) had significantly higher amounts of calcified deposits than IOLs of other materials, indicating that hydrophilic acrylic IOLs easily accumulate calcified deposits in the body when the concentrations of calcium, phosphate, and albumin in the aqueous humor fluctuate as a result of a blood-aqueous barrier breakdown.
authors.affiliation: Omori Medical Center, Department of Ophthalmology, Toho University, Tokyo, Japan. saisai0117@yahoo.co.jp
authors.forename: Saiko
authors.initials: S
authors.lastname: Nakanome
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tochikubo
mesh_terms: D000180:Acrylic Resins; D000418:Albumins / Q000378:metabolism; D001082:Aqueous Humor / Q000378:metabolism*; D018916:Blood-Aqueous Barrier; D002114:Calcinosis / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002199:Capillary Permeability; D003930:Diabetic Retinopathy / Q000150:complications; D004577:Electron Probe Microanalysis; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D018918:Phacoemulsification; D010758:Phosphorus / Q000378:metabolism*; D019904:Polymethyl Methacrylate; D011475:Prosthesis Failure; D012086:Reoperation; D012826:Silicone Elastomers
chemical_list: D000180:Acrylic Resins; D000418:Albumins; D012826:Silicone Elastomers; D010758:Phosphorus; D019904:Polymethyl Methacrylate; D002118:Calcium