title: [The role of gastric acid in the H. pylori-induced gastritis in mouse].
abstract: OBJECTIVE
  This study was designed to investigate the role of gastric acid in the extent of H. pylori-induced gastritis.
  
  
  METHODS
  Twenty eight mice were inoculated with live H. pylori. They were allocated into four groups. Mice in group I received no treatment, group II mice were treated with sham injection, group III received 125 microg/kg body weight of pentagastrin, while group IV received 250 microg/kg body weight of pentagastrin subcutaneously three times a week. After 7 months, the mucosal pH, H. pylori density, neutrophils and monocytes infiltration, and the degree of atrophy were assessed in the stomach.
  
  
  RESULTS
  In the gastric body, the densities of H. pylori were not different among groups. The degree of neutrophil infiltration was significantly lower in group IV compared to other groups (p<0.05). The degree of monocyte infiltration was also significantly lower in group IV than group III (p<0.05). In the gastric antrum, there was no significant difference of the H. pylori density, neutrophil and monocyte infiltration, and degree of atrophy among the groups. The mice with the gastric mucosal pH lower than mean of 3.2 had significant lower level of H. pylori density (1.4 vs. 2.4, p=0.04), and infiltration of neutrophils (0.9 vs. 2.3, p=0.018), and monocytes (1.2 vs. 1.8; p=0.011) than the those with mucosal pH above 3.2 in the body of stomach.
  
  
  CONCLUSIONS
  Gastric acid plays a role in suppressing the proximal propagation of H. pylori-induced gastritis to the body of stomach.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. kimss@catholic.ac.kr
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Yeo Min
authors.initials: YM
authors.lastname: Lee
authors.forename: Hyung Keun
authors.initials: HK
authors.lastname: Kim
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Hiun Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: In Sik
authors.initials: IS
authors.lastname: Chung
authors.forename: Doo Ho
authors.initials: DH
authors.lastname: Park
mesh_terms: D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal