title: TRP channels and mechanosensory transduction: insights into the arterial myogenic response.
abstract: Mechano-gated ion channels are implicated in a variety of key physiological functions ranging from touch sensitivity to arterial pressure regulation. Seminal work in prokaryotes and invertebrates provided strong evidence for the role of specific ion channels in volume regulation, touch sensitivity, or hearing, specifically the mechanosensitive channel subunits of large and small conductances (MscL and MscS), the mechanosensory channel subunits (MEC) and the transient receptor potential channel subunits (TRP). In mammals, recent studies further indicate that members of the TRP channel family may also be considered as possible candidate mechanosensors responding to either tension, flow, or changes in cell volume. However, contradictory results have challenged whether these TRP channels, including TRPC1 and TRPC6, are directly activated by mechanical stimulation. In the present review, we will focus on the mechanosensory function of TRP channels, discuss whether a direct or indirect mechanism is at play, and focus on the proposed role for these channels in the arterial myogenic response to changes in intraluminal pressure.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis 06560, France.
authors.forename: Reza
authors.initials: R
authors.lastname: Sharif-Naeini
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dedman
authors.forename: Joost H A
authors.initials: JH
authors.lastname: Folgering
authors.forename: Fabrice
authors.initials: F
authors.lastname: Duprat
authors.forename: Amanda
authors.initials: A
authors.lastname: Patel
authors.forename: Bernd
authors.initials: B
authors.lastname: Nilius
authors.forename: Eric
authors.initials: E
authors.lastname: Honoré
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism*; D001794:Blood Pressure; D006801:Humans; D015640:Ion Channel Gating; D040542:Mechanotransduction, Cellular; D008564:Membrane Potentials; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D012039:Regional Blood Flow; D050052:TRPC Cation Channels / Q000378:metabolism; D050053:TRPM Cation Channels / Q000378:metabolism; D050396:TRPP Cation Channels / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism*; D014661:Vasoconstriction
chemical_list: D050052:TRPC Cation Channels; D050053:TRPM Cation Channels; D050396:TRPP Cation Channels; D050916:TRPV Cation Channels; D050051:Transient Receptor Potential Channels; C096351:transient receptor potential cation channel, subfamily C, member 1