Severe low turnover osteoporosis.
Severe osteoporosis, a situation with fractures, can worsen in the case of poor response to usual therapies, such as bisphosphonates associated with calcium and vitamin D, especially if bone turnover is strongly suppressed. One way of inverting the poor evolution of non-responders is to use Teriparatide. The case of a non-responder is reported, with considerations about the possibility of detecting these patients before a new fracture takes place.
Pietrogrande
Luca
L
Orthopedic Clinic, DMCO San Paolo, University of Milano, Milano, Italy. luca.pietrogrande@unimi.it
D000368:Aged; D001416:Back Pain / Q000188:drug therapy / Q000209:etiology; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use; D016723:Bone Remodeling / Q000187:drug effects; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005598:Fractures, Spontaneous / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography; D019379:Teriparatide / Q000627:therapeutic use*
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019379:Teriparatide