title: The effect of ABO blood group on von Willebrand response to exercise.
abstract: Individuals of O blood group have significantly lower plasma levels of either Factor VIII (FVIII) or the von Willebrand factor (vWF). Conversely, there is accumulating evidence that elevated FVIII-vWF levels may represent an important risk factor for ischemic heart and venous thromboembolic disease. In this study, individuals exercised for 20 minutes at 10% below the first ventilatory threshold (aerobic threshold), which corresponds to 48% of maximum oxygen uptake. People with non-O blood group show higher resting and postexercise vWF levels compared with those of O blood group, as evidenced by a lower maximal heart rate. The groups were compared using the ANOVA one-way test, and a P < 0.05 was considered statistically significant. These results could change the way in which exercise training is designed for both healthy and sick individuals because O group individuals could have a more thrombogenic response to exercise.
authors.affiliation: Exercise Research Laboratory, Physical Education School, Federal University of Rio Grande do Sul, Brazil. jerriribeiro@yahoo.com.br
authors.forename: Jerri L
authors.initials: JL
authors.lastname: Ribeiro
authors.forename: Gabriele D
authors.initials: GD
authors.lastname: Salton
authors.forename: Eliane
authors.initials: E
authors.lastname: Bandinelli
authors.forename: Alvaro R
authors.initials: AR
authors.lastname: Oliveira
authors.forename: Israel
authors.initials: I
authors.lastname: Roisenberg
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008297:Male; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D000017:ABO Blood-Group System; D014841:von Willebrand Factor