How accurate is the description of transport kinetics in peritoneal dialysis according to different versions of the three-pore model?
OBJECTIVE
The three-pore model of peritoneal transport is used extensively for modeling peritoneal fluid and solute transport, but the currently used versions include certain modifications of the transport parameters that have not been validated quantitatively versus detailed data on fluid and solute kinetics. The aim of this study was to evaluate different versions of the three-pore model.


METHODS
Detailed clinical peritoneal fluid and solute transport data were obtained from 40 peritoneal dwell studies in clinically stable continuous ambulatory peritoneal dialysis patients in whom the dialysate volume was measured using a macromolecular volume marker (RISA).


RESULTS
Using a new version of the three-pore model with several adjusted transport parameters, good agreement between the measured and the simulated values of dialysate volume and concentrations of small solutes and RISA (but not of endogenous protein) versus dwell time was obtained; however, the predicted peritoneal absorption for longer than the investigated dwell time would be too high.


CONCLUSIONS
The three-pore model, with some adjustments proposed in this study, may be used for detailed description of peritoneal transport kinetics, but it should be pointed out that, even after these adjustments, it still does not provide the correct description of peritoneal fluid absorption and transport of macromolecules.
Waniewski
Jacek
J
Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland. jecekwan@ibib.waw.pl
Debowska
Malgorzata
M
Lindholm
Bengt
B
D001202:Ascitic Fluid / Q000378:metabolism*; D001692:Biological Transport; D003404:Creatinine / Q000378:metabolism; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015203:Reproducibility of Results; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism
D015314:Dialysis Solutions; D014508:Urea; D012964:Sodium; D003404:Creatinine; D005947:Glucose