title: Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation.
abstract: Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(I) chelate is formed.
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: James M
authors.initials: JM
authors.lastname: Takacs
mesh_terms: D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry*; D006865:Hydrogenation; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017905:Phosphites / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002614:Chelating Agents; D008024:Ligands; D047028:Macrocyclic Compounds; D017905:Phosphites; D012238:Rhodium