Improving growth in children with inflammatory bowel disease.
BACKGROUND
Growth in children with inflammatory bowel disease (IBD) is affected through a number of mechanisms; controlling disease activity and supporting poor nutritional status are paramount in these patients. Further understanding of the basic mechanisms by which cytokines influence growth will facilitate the development of therapeutic modalities to improve growth.


CONCLUSIONS
Clinical management that addresses growth and puberty in children with IBD should be a partnership between paediatric gastroenterologists and endocrinologists. Well-designed studies of growth-promoting hormonal treatment may answer questions regarding the efficacy and safety of treating growth retardation in the subgroup of patients who continue to fail to grow despite optimal management of their IBD.
Ahmed
S Faisal
SF
Bone & Endocrine Research Group, University of Glasgow, Glasgow, UK. gcl328@clinmed.gla.ac.uk
Wong
Jarod S C
JS
McGrogan
Paraic
P
D000075202:Contraindications; D016207:Cytokines / Q000378:metabolism; D005938:Glucocorticoids; D006128:Growth; D006130:Growth Disorders / Q000209:etiology; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy / Q000503:physiopathology*; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use
D016207:Cytokines; D005938:Glucocorticoids; D018836:Inflammation Mediators; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I