Trichodermatides A-D, novel polyketides from the marine-derived fungus Trichoderma reesei.
Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line.
Sun
Yi
Y
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Tian
Li
L
Huang
Jian
J
Ma
Hong-Yu
HY
Zheng
Zhe
Z
Lv
A-Li
AL
Yasukawa
Ken
K
Pei
Yue-Hu
YH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D014242:Trichoderma / Q000737:chemistry*
D000970:Antineoplastic Agents; D018942:Macrolides; C527910:trichodermatide A