title: The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss.
abstract: Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of .03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study.
authors.affiliation: Department of Pediatric Molecular Genetics, Medical School of Ankara University, Ankara, Turkey.
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Yildiz
authors.forename: Arzu
authors.initials: A
authors.lastname: Ulu
authors.forename: Armagan
authors.initials: A
authors.lastname: Incesulu
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Ozkaptan
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D000074283:Endothelial Protein C Receptor; D005165:Factor V / Q000235:genetics; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood / Q000209:etiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000150:complications* / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D017395:Plasminogen Activator Inhibitor 1; D011956:Receptors, Cell Surface; C051321:SERPINE1 protein, human; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)