title: Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.
abstract: In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.
authors.affiliation: Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany. owirths@uni-goettingen.de
authors.forename: O
authors.initials: O
authors.lastname: Wirths
authors.forename: T A
authors.initials: TA
authors.lastname: Bayer
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000209:etiology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D016875:tau Proteins