title: Expression of PINCH protein in gliomas and its clinicopathological significance.
abstract: OBJECTIVE
  Particularly interesting new cysteine-histidine-rich protein (PINCH), as a LIM domain adapter protein, functions in the integrin and growth factor signal transduction pathway, and is upregulated in tumor-associated stroma in several types of cancers. However, no study of PINCH has been carried out in gliomas, therefore we examined PINCH expression in gliomas and its clinicopathological significance.
  
  
  METHODS
  PINCH expression was immunohistochemically examined in 82 gliomas, along with 26 matched adjacent normal brain samples and 10 recurred gliomas.
  
  
  RESULTS
  PINCH was strongly expressed in the primary (35%, p = 0.0001) or recurred tumors (40%, p = 0.004) and weak in normal brain tissue. PINCH expression was significantly increased in high-grade gliomas (55 vs. 24%, high- vs. low-grade gliomas, p = 0.004). There was no association of PINCH expression with gender, age, tumor number, size, histological type and tumor location (p > 0.05).
  
  
  CONCLUSIONS
  PINCH expression may be involved in glioma development and differentiation.
authors.affiliation: Department of Neurology, First Hospital, Hebei Medical University, Shijiazhuang, China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Zhen-Long
authors.initials: ZL
authors.lastname: Zhu
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Li
authors.forename: Hui-Xin
authors.initials: HX
authors.lastname: Zhao
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D060588:LIM Domain Proteins; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; C088088:LIMS1 protein, human; D008565:Membrane Proteins