title: High dose clopidogrel decreases mice liver mitochondrial respiration function in vitro.
abstract: The effects of clopidogrel on mitochondrial respiratory function have not been previously investigated. We show in vitro that isolated mice liver mitochondria treated with very high doses of clopidogrel 10 microg/ml significantly reduces pre-treatment mitochondrial respiratory state 3 (P<0.05) and state 4 respiration (P<0.01), while oxygen consumption in State 3 is prolonged. This suggests a compromise to mitochondrial oxidative phosphorylation following the addition of high dose clopidogrel. Because clopidogrel at human therapeutic doses 40 ng/ml did not affect isolated mitochondrial respiration, it is thus unlikely, in the absence of cellular bioaccumulation, that clinical doses of clopidogrel would affect mitochondrial bioenergetics in vivo.
authors.forename: Yee Kit
authors.initials: YK
authors.lastname: Tai
authors.forename: Yuh Meng Clement
authors.initials: YM
authors.lastname: Cheong
authors.forename: Zakaria A
authors.initials: ZA
authors.lastname: Almsherqi
authors.forename: Shu Hui
authors.initials: SH
authors.lastname: Chia
authors.forename: Yuru
authors.initials: Y
authors.lastname: Deng
authors.forename: Craig S
authors.initials: CS
authors.lastname: McLachlan
mesh_terms: D000818:Animals; D019069:Cell Respiration / Q000187:drug effects*; D000077144:Clopidogrel; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008930:Mitochondria, Liver / Q000187:drug effects*; D023421:Models, Animal; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine