[Preliminary results of Lacofem trial--first impressions].
OBJECTIVE
To study the efficacy of vaginal application of Lactofem (viable Lactobacilli) in cases of vaginal microflora disturbances.


METHODS
32 patient between 18-32 years (12 of them, suffering from vulvovaginal candidosis-VVC, 20--with bacterial vaginosis- BV) were included in a placebo controlled trial. In all of them no Lactobacilli were found on vaginal smear preparation.


RESULTS
After one month 90% of women with VVC, treated with Lactofem were cured, compared to 83% in the placebo group. Application of Lactofem resulted in cure rate of 90% in the BV group. In the placebo group cure rate of 67% was achieved. After 3 months of application, VVC was eradicated in 100% of cases in Lactofem group and in 85% of cases in the placebo group. BV was cured in 90% of women, using Lactofem and in 50% of patients, using placebo. Only one patient had mild and temporary side effect.
Sigridov
I
I
Ivanov
St
S
Batashki
I
I
D000293:Adolescent; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000166:cytology / Q000302:isolation & purification; D010919:Placebos; D019936:Probiotics / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000150:complications / Q000628:therapy*
D010919:Placebos