The effect of activated factor VII for intracerebral hemorrhage beyond 3 hours versus within 3 hours.
OBJECTIVE
Recombinant-activated factor VII (rFVIIa) is an investigational treatment for intracerebral hemorrhage (ICH). We have evaluated the drug's treatment effect based on time to treatment.


METHODS
ICH patients treated up to 4 hours from symptom onset were divided based on time to treatment: <or=3 hours (3H) and 3 to 4 hours (4H). Head CT was done at baseline and 24 hours. Outcome measures included: ICH growth at 24 hours, mortality, favorable outcome and discharge disposition. A cohort of nontreated matched ICH patients was used to asses the clinical efficacy.


RESULTS
Forty-six patients were treated with rFVIIa: 24 in the 3H group (range 70 to 180 minutes), 22 in the 4H group (range 181 to 300). One hundred and forty-eight patients formed the control group. Mean baseline ICH volume was 8.8 mL for 3H and 10.1 mL for 4H. Mean 24-hour volume was 9.3 mL for 3H (absolute increase 1.05 mL, relative increase 11.9%) and 11.5 mL for 4H (absolute increase 1.1 mL, relative increase 10.9%); P=0.47 is for the difference in relative increase. Mortality was 12.5% for 3H group, 13.6% for 4H, and 13.1% for the control. In the 3H group, 58.3% were discharged with a poor outcome, compared with 54.5% in 4H and 54.1% in the control. Thrombotic adverse events occurred in 11.1% of patients treated with rFVIIa.


CONCLUSIONS
In our off-label with rFVIIa, we did not find evidence of a treatment effect based on time to treatment. Other criteria should be sought to identify patients who might benefit clinically from rFVIIa.
Hallevi
Hen
H
Gonzales
Nicole R
NR
Barreto
Andrew D
AD
Martin-Schild
Sheryl
S
Albright
Karen C
KC
Noser
Elizabeth A
EA
Illoh
Kachi
K
Khaja
Aslam M
AM
Allison
Teresa
T
Escobar
Miguel A
MA
Shaltoni
Hashem M
HM
Grotta
James C
JC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000188:drug therapy* / Q000401:mortality; D015331:Cohort Studies; D015942:Factor VIIa / Q000008:administration & dosage* / Q000009:adverse effects; D006406:Hematoma / Q000097:blood / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D015942:Factor VIIa