The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.
Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
Helgadottir
Anna
A
deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Thorleifsson
Gudmar
G
Magnusson
Kristinn P
KP
Grétarsdottir
Solveig
S
Steinthorsdottir
Valgerdur
V
Manolescu
Andrei
A
Jones
Gregory T
GT
Rinkel
Gabriel J E
GJ
Blankensteijn
Jan D
JD
Ronkainen
Antti
A
Jääskeläinen
Juha E
JE
Kyo
Yoshiki
Y
Lenk
Guy M
GM
Sakalihasan
Natzi
N
Kostulas
Konstantinos
K
Gottsäter
Anders
A
Flex
Andrea
A
Stefansson
Hreinn
H
Hansen
Torben
T
Andersen
Gitte
G
Weinsheimer
Shantel
S
Borch-Johnsen
Knut
K
Jorgensen
Torben
T
Shah
Svati H
SH
Quyyumi
Arshed A
AA
Granger
Christopher B
CB
Reilly
Muredach P
MP
Austin
Harland
H
Levey
Allan I
AI
Vaccarino
Viola
V
Palsdottir
Ebba
E
Walters
G Bragi
GB
Jonsdottir
Thorbjorg
T
Snorradottir
Steinunn
S
Magnusdottir
Dana
D
Gudmundsson
Gudmundur
G
Ferrell
Robert E
RE
Sveinbjornsdottir
Sigurlaug
S
Hernesniemi
Juha
J
Niemelä
Mika
M
Limet
Raymond
R
Andersen
Karl
K
Sigurdsson
Gunnar
G
Benediktsson
Rafn
R
Verhoeven
Eric L G
EL
Teijink
Joep A W
JA
Grobbee
Diederick E
DE
Rader
Daniel J
DJ
Collier
David A
DA
Pedersen
Oluf
O
Pola
Roberto
R
Hillert
Jan
J
Lindblad
Bengt
B
Valdimarsson
Einar M
EM
Magnadottir
Hulda B
HB
Wijmenga
Cisca
C
Tromp
Gerard
G
Baas
Annette F
AF
Ruigrok
Ynte M
YM
van Rij
Andre M
AM
Kuivaniemi
Helena
H
Powell
Janet T
JT
Matthiasson
Stefan E
SE
Gulcher
Jeffrey R
JR
Thorgeirsson
Gudmundur
G
Kong
Augustine
A
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K
D000328:Adult; D000368:Aged; D000483:Alleles; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics* / Q000503:physiopathology; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D011336:Probability; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D044465:White People
D005819:Genetic Markers