Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration.
The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.
Chen
Zhuo
Z
Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
Wang
Xianyou
X
Song
Baoan
B
Wang
Hua
H
Bhadury
Pinaki S
PS
Yan
Kai
K
Zhang
Huiping
H
Yang
Song
S
Jin
Linhong
L
Hu
Deyu
D
Xue
Wei
W
Zeng
Song
S
Wang
Jun
J
D000998:Antiviral Agents / Q000737:chemistry*; D003487:Cyanoacrylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008872:Microwaves; D010935:Plant Diseases / Q000821:virology; D018515:Plant Leaves / Q000821:virology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000998:Antiviral Agents; D003487:Cyanoacrylates