title: Rod progenitor cells in the mature zebrafish retina.
abstract: The zebrafish is an excellent model organism in which to study the retina's response to photoreceptor degeneration and/or acute injury. While much has been learned about the retinal stem and progenitor cells that mediate the damage response, several questions remain that cannot be addressed by acute models of injury. The development of genetic models, such as the XOPS-mCFP transgenic line, should further efforts to understand the nature of the signals that promote rod progenitor proliferation and differentiation following photoreceptor loss. This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes.
authors.affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA. amorris@bio.fsu.edu
authors.forename: Ann C
authors.initials: AC
authors.lastname: Morris
authors.forename: Tamera
authors.initials: T
authors.lastname: Scholz
authors.forename: James M
authors.initials: JM
authors.lastname: Fadool
mesh_terms: D000818:Animals; D008954:Models, Biological; D012160:Retina / Q000166:cytology*; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*; D015027:Zebrafish / Q000502:physiology*