Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy.
A simultaneous evaluation of presynaptic and postsynaptic dopaminergic positron emission tomography markers, the dopamine transporters and the dopamine D2-like receptors, was performed in eight patients with parkinsonian phenotype of multiple system atrophy. Both presynaptic and postsynaptic markers were revealed to have declined in such a manner that they kept strong positive correlation throughout the striatum of all patients, suggesting that the degeneration process in the striatum may involve the entire structure of the dopaminergic synapse. In two L-3,4,dihydroxyphenyl-alanine-responsive cases, the balance of decline in two markers was relatively shifted to presynaptic dominant side. Correlative positron emission tomography study of presynaptic and postsynaptic dopaminergic function may be useful for the diagnosis of multiple system atrophy and to understand the mechanisms of its temporal L-3,4,dihydroxyphenyl-alanine responsiveness.
Hashimoto
Masaya
M
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Kawasaki
Keiichi
K
Suzuki
Masahiko
M
Mitani
Kazuko
K
Murayama
Shigeo
S
Mishina
Masahiro
M
Oda
Keiichi
K
Kimura
Yuichi
Y
Ishiwata
Kiichi
K
Ishii
Kenji
K
Inoue
Kiyoharu
K
D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D003712:Dendrites / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D017729:Presynaptic Terminals / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D015415:Biomarkers; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; D007980:Levodopa; D004298:Dopamine