title: Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gray and white matter vulnerability.
abstract: OBJECTIVE
  Symptomatic progression is frequently observed in lacunar infarcts. The exact mechanisms of this phenomenon have not yet been clarified.
  
  
  METHODS
  We report 2 patients with lenticulostriate artery infarcts that presented with skip lesions that were restricted to gray matter. One of the patients subsequently developed symptomatic deterioration; the other experienced no further neurological events.
  
  
  CONCLUSIONS
  A possible mechanism of differential vulnerability to ischemia of gray and white matter is considered. White matter may have a longer therapeutic time window for neuroprotective treatment than gray matter.
authors.affiliation: Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. nagakane@koto.kpu-m.ac.jp
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Nagakane
authors.forename: Kei
authors.initials: K
authors.lastname: Yamada
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ohara
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Nagato
authors.initials: N
authors.lastname: Kuriyama
authors.forename: Natsuko
authors.initials: N
authors.lastname: Takayasu
authors.forename: Takashi
authors.initials: T
authors.lastname: Kasai
authors.forename: Natsuko
authors.initials: N
authors.lastname: Yuki
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Nishimura
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000473:pathology*; D020520:Brain Infarction / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D020772:Internal Capsule / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D011699:Putamen / Q000473:pathology; D020521:Stroke / Q000473:pathology*