Proteolytic activity of Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane.
Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of 1,4,7,10-tetraazacyclododecane by using albumin, gamma-globulin, and myoglobin as substrates. Values of kcat/Km were greater for Cu(II)oxacyclen by 40-80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom with oxygen.
Jang
Seung Woo
SW
Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
Suh
Junghun
J
D003300:Copper / Q000737:chemistry*; D006868:Hydrolysis; D045726:Metalloproteases / Q000138:chemical synthesis* / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism
D009942:Organometallic Compounds; D003300:Copper; D045726:Metalloproteases