Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss.
OBJECTIVE
To investigate the association of the common protein Z (PZ) intron F G79A gene polymorphism with recurrent early pregnancy loss (RPL) and its gene-gene interaction with known thrombophilic risk factors for RPL.


METHODS
Case control study.


METHODS
University clinic.


METHODS
We enrolled 49 women with a history of two consecutive or three to six nonconsecutive pregnancy losses between the 8th and 12th weeks of gestation and 48 age-matched parous controls without a history of pregnancy complications.


METHODS
None.


METHODS
Allele frequencies of the PZ intron F G79A polymorphism and its gene-gene interaction with known risk factors for RPL.


RESULTS
Fourteen case subjects (28.6%) and 24 control subjects (50.0%) carried at least one A allele. This was associated with a significant reduction of the relative risk for recurrent pregnancy loss (odds ratio [OR] 0.4, 95% confidence interval [CI] 0.2-0.9; adjusted OR 0.3, 95% CI 0.1-0.8). Coexistence of any thrombophilic risk factor studied with the 79A allele resulted in a clear reduction of the primal relative risk for recurrent pregnancy loss.


CONCLUSIONS
The isolated presence of the PZ intron F 79A allele as well as the combination with known thrombophilic risk factors was protective against RPL between the 8th and 12th weeks of gestation.
Dossenbach-Glaninger
Astrid
A
Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
van Trotsenburg
Michael
M
Helmer
Hanns
H
Oberkanins
Christian
C
Hopmeier
Pierre
P
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D001798:Blood Proteins; C026080:plasma protein Z