title: Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration.
abstract: To better define the anatomic distinctions between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), we retrospectively applied voxel-based morphometry to the earliest magnetic resonance imaging scans of autopsy-proven AD (N = 11), FTLD (N = 18), and controls (N = 40). Compared with controls, AD patients showed gray matter reductions in posterior temporoparietal and occipital cortex; FTLD patients showed atrophy in medial prefrontal and medial temporal cortex, insula, hippocampus, and amygdala; and patients with both disorders showed atrophy in dorsolateral and orbital prefrontal cortex and lateral temporal cortex (P(FWE-corr) < .05). Compared with FTLD, AD patients had decreased gray matter in posterior parietal and occipital cortex, whereas FTLD patients had selective atrophy in anterior cingulate, frontal insula, subcallosal gyrus, and striatum (P < .001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD.
authors.affiliation: Memory and Aging Center, University of California, San Francisco, California 94143, USA. grabinovici@memory.ucsf.edu
authors.forename: G D
authors.initials: GD
authors.lastname: Rabinovici
authors.forename: W W
authors.initials: WW
authors.lastname: Seeley
authors.forename: E J
authors.initials: EJ
authors.lastname: Kim
authors.forename: M L
authors.initials: ML
authors.lastname: Gorno-Tempini
authors.forename: K
authors.initials: K
authors.lastname: Rascovsky
authors.forename: T A
authors.initials: TA
authors.lastname: Pagliaro
authors.forename: S C
authors.initials: SC
authors.lastname: Allison
authors.forename: C
authors.initials: C
authors.lastname: Halabi
authors.forename: J H
authors.initials: JH
authors.lastname: Kramer
authors.forename: J K
authors.initials: JK
authors.lastname: Johnson
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
authors.forename: M S
authors.initials: MS
authors.lastname: Forman
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: S J
authors.initials: SJ
authors.lastname: Dearmond
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: H J
authors.initials: HJ
authors.lastname: Rosen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D000679:Amygdala / Q000473:pathology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D003704:Dementia / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D020961:Lewy Body Disease / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged