A report of supratentorial leptomeningeal hemangioblastoma and a literature review.
Hemangioblastomas of the CNS are solid or cystic vascular-rich tumors, most common in the cerebellum, less frequent in the brainstem or spinal cord, and rare in supratentorial locations with meningeal involvement. We document a case in a 58-year-old man who presented with about 2 months history of motor weakness and speech dysfunction. The tumor was a heterogeneously enhanced dural-based tumor with high vascularity and perifocal edema in the left frontal lobe. The tumor was completely removed followed by embolization and preoperative radiotherapy. Histologic examination revealed a hemangioblastoma with features resembling angiomatous meningioma. Immunohistochemistry for epithelial membrane antigen (EMA) and S100 may be helpful to make differential diagnosis. Electron microscopic investigation is essential to differentiate between meningiomas and other leptomeningeal tumors.
Takeuchi
Hiroaki
H
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan. takeu@fmsrsa.fukui-med.ac.jp
Hashimoto
Norichika
N
Kitai
Ryuhei
R
Kubota
Toshihiko
T
D003937:Diagnosis, Differential; D018325:Hemangioblastoma / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D008579:Meningioma / Q000473:pathology; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D015173:Supratentorial Neoplasms / Q000378:metabolism / Q000648:ultrastructure*