Chinese medicine formula DSQRL versus glucocorticoids for the treatment of experimental pulmonary fibrosis.
Pulmonary fibrosis (PF) is a devastating interstitial lung disease that may develop idiopathically or as a complication of many other diseases. The outcome of the current main treatment by glucocorticoids is by no means satisfactory. This study has tested a new Chinese medicine Decoction for Strengthening Qi and Replenishing Lung (DSQRL) for the treatment of experimental PF in comparison with prednisolone. Eighty-five rats with PF induced by CCl(4) were randomly divided into 4 groups to undertake treatment either by (a) high dose of prednisolone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) sham feeding of water in equal volume. At the end of 60 days treatment, the DSQRL treatment achieved a significantly better outcome than prednisolone in terms of general behavior, histological examination, hydroxyproline content of the lung and inflammatory cell counts in bronchoalveolar lavage fluid. Thus, the newly proposed Chinese medicinal formula DSQRL appears to be a better and promising option for PF than glucocorticoids for the treatment of PF.
Zhang
Hong-Qi
HQ
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. hqzhang@hkbu.edu.hk
Yau
Yu-Fung
YF
Wong
Man-Sin
MS
Man
Oi-Yan
OY
He
Ying-Ying
YY
Chan
Nickie
N
Li
Min
M
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D008297:Male; D008516:Medicine, Chinese Traditional; D011241:Prednisone / Q000627:therapeutic use*; D011658:Pulmonary Fibrosis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D011241:Prednisone