[Transcription of the KLRB1 gene is suppressed in human cancer tissues].
The KLRB1 gene encodes the CD161 receptor of natural killer cells (NK-cells). The gene is also expressed in the NKT-cells. The two cell types are cytotoxic and capable of recognizing and eliminating various cell species, e.g. tumorous, virus-infected, and allotransplants. The biological function of human CD161 is still insufficiently understood; probably it is involved in regulation of the cytotoxic functions of the cells and in regulation of cytokine production. Because immune system, in particular, the activity of cytotoxic cells, is suppressed in most cancer patients, it was suggested that the KLRB1 expression might be suppressed in cancerous cells. The results of this work demonstrated that the transcription of the KLRB1 was suppressed in tumor tissues in 68% patients with nonsmall-lung-cancer (p < 0.0001) and 57% patients with esophageal squamous-cell carcinoma (p = 0.0003). High frequency of the KLRB1 transcription suppression upon cancers makes it possible to use this parameter as a highly informative marker of lung and esophageal cancers.
Pleshkan
V V
VV
Zinov'eva
M V
MV
Vinogradova
T V
TV
Sverdlov
E D
ED
D000954:Antigens, Surface / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D055651:NK Cell Lectin-Like Receptor Subfamily B; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface; D014408:Biomarkers, Tumor; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B