title: Does the copper intrauterine device affect serum cancer antigen 125 levels?
abstract: OBJECTIVE
  This study aimed to reveal the effect of the copper IUD, if any, on serum CA-125 levels in patients who use the device as a contraceptive.
  
  
  METHODS
  Blood samples were obtained two times from 20 healthy volunteers before and after IUD insertion, and sera were isolated. The sera, centrifuged at 2000 G and kept at -70 degrees C in a deep freezer until analyzed, were processed for CA-125 levels by the CA-125 kit using VIDAS PC analyzer (Biomerieux, France) and results were compared.
  
  
  RESULTS
  The CA-125 level of the serum obtained from the first blood samples was significantly higher than that of the second sample (24.63 +/- 25.40 mIU/ml and 14.44 +/- 10.08 mIU/ml, respectively) (p < 0.05).
  
  
  CONCLUSIONS
  The results of this study indicate that the serum level of CA-125 may be lower in patients using copper IUDs which may be helpful in evaluation of ovarian masses in women in reproductive age.
authors.affiliation: Department of Obstetrics and Gynecology, Kafkas University Medical Faculty, Kars, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Karaca
authors.forename: S
authors.initials: S
authors.lastname: Kumru
authors.forename: N
authors.initials: N
authors.lastname: Dikmeli
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D003300:Copper; D005260:Female; D006801:Humans; D007434:Intrauterine Devices
chemical_list: D018394:CA-125 Antigen; D003300:Copper