Mouse models for understanding the growth hormone insulin-like growth factor-I axis.
BACKGROUND
Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass.


CONCLUSIONS
Mouse models continue to deepen our understanding of IGF-I signaling and the role of IGF-I in determining marrow stromal cell fate.
Rosen
Clifford J
CJ
Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Me. 04401, USA. crosen@maine.maine.edu
D050156:Adipogenesis / Q000502:physiology; D000273:Adipose Tissue / Q000502:physiology; D000483:Alleles; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009154:Mutation; D010012:Osteogenesis / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D015398:Signal Transduction; D017154:Stromal Cells / Q000502:physiology
D047495:PPAR gamma; D007334:Insulin-Like Growth Factor I