[Antimicrobial activity of core-sheath surgical sutures modified with poly-3-hydroxybutyrate].
To impart antimicrobial activity to surgical sutures, weaved polyester fibers are coated with poly-3-hydroxybutyrate (PHB), containing the antimicrobial agent furazolidone (FZ). The prolonged FZ effect (7-14 days) is achieved by two-step application of a sheath, constituting 10% of the suture weight and containing 2-6% FZ. The sheath structure and antimicrobial activity of sutures can be modified by the introduction of other biocompatible and biodegradable polymers.
Fedorov
M B
MB
Vikhoreva
G A
GA
Kil'deeva
N R
NR
Mokhova
O N
ON
Bonartseva
G A
GA
Gal'braĭkh
L S
LS
D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D005664:Furazolidone / Q000737:chemistry / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000737:chemistry*; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013537:Sutures; D000094122:Polyhydroxybutyrates
D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D005664:Furazolidone; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates