Vertical hepatitis C virus transmission is not related to mother-child class-1 HLA concordance.
Mother-child human leukocyte antigen (HLA)diversity is protective for vertical transmission of some viruses. The aim of this study is to evaluate the role of mother-child HLA diversity on hepatitis C virus (HCV) vertical transmission. Forty consecutive HCV infected and 46 consecutive control uninfected children born to HCV-RNA positive mothers were evaluated for HLA class-1 type concordance with their mothers. No significant difference in the degree of HLA concordance was found between HCV infected and uninfected children both when A, B, C (p=0.30) and when only A and B alleles were evaluated (p=0.59). Mother-infant HLA concordance does not affect HCV vertical transmission.
Azzari
C
C
Department of Paediatrics, University of Florence, Anna Meyer Children's Hospital, Florence, Italy. maurizio.demartino@unifi.it
Indolfi
G
G
Betti
L
L
Moriondo
M
M
Massai
C
C
Becciolini
L
L
Bertelli
L
L
Poggi
G M
GM
De Martino
M
M
Resti
M
M
D000328:Adult; D000483:Alleles; D000940:Antigenic Variation / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000151:congenital / Q000635:transmission* / Q000821:virology; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D012313:RNA / Q000096:biosynthesis / Q000235:genetics
D006680:HLA Antigens; D012313:RNA