Two separated ileal adenocarcinomas in neurofibromatosis type 1.
Patients with neurofibromatosis-1 (NF-1) have increased susceptibility to a variety of malignancies. Here, we document a rare case of two separated ileal adenocarcinomas in NF-1. The adenocarcinomas were surrounded by a diffuse tubular adenomatous lesion of the mucosa, and ganglion cells were scattered in the NF background. We found this case meaningful for several reasons: two separated adenocarcinomas arising in an unusual ileal segment, the association with precancerous tubular adenoma, and the presence of ganglion cells, which suggests ganglioneuromatosis in NF-1.
Hwangbo
Seal
S
Department of Radiology, College of Medicine, Catholic University of Korea, Daejeon St. Mary's Hospital, Deajeon, Korea.
Kim
Jiyoun
J
Kim
Hyun
H
Kim
Jongok
J
Kang
Changsuk
C
Lee
Hyekyung
H
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000328:Adult; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000473:pathology*; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology*