title: Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous cell carcinoma?
abstract: OBJECTIVE
  This study was designed to compare the effectiveness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in the pretherapeutic staging of squamous cell carcinoma (SCC) of the head and neck.
  
  
  METHODS
  The study included 34 consecutive patients (27 males, 7 females; mean age 61 years; range 42 to 82 years) with SCC of the head and neck. All the patients underwent whole body [18F]fluorodeoxyglucose (FDG)-PET and MRI scans for pretherapeutic evaluation. Diagnoses were confirmed by histopathologic examination of endoscopic biopsy specimens.
  
  
  RESULTS
  The sites of the primary tumors were the oropharynx (n=15, 44%), larynx (n=10, 29%), hypopharynx (n=8, 24%), and nasopharynx (n=1, 3%). Surgery was the treatment of choice in 20 patients (59%), including 23 neck dissections. Fourteen patients (41%) were treated with radiochemotherapy. Both PET and MRI were able to detect the primary tumor in 33 cases (97%). In two patients (6%), PET was able to detect distant metastases in the lung and iliac bone, all of which were confirmed by biopsies. Seven neck specimens (30%) showed lymph node metastasis. Sensitivity and specificity rates for detection of lymph node metastasis were 100% and 87.5% for PET, and 85.7% and 87.5% for MRI, respectively.
  
  
  CONCLUSIONS
  Although PET seems to be superior to MRI in detecting nodal disease and distant metastases, it is still early to recommend it as a primary tool for pretherapeutic evaluation of head and neck cancers due to its limited availability and higher cost.
authors.affiliation: Department of Otolaryngology, Head and Neck and Facial Plastic Surgery, Klinikum Fulda gAG, Teaching Hospital of the Philipps-University, Fulda, Germany.
authors.forename: Amir
authors.initials: A
authors.lastname: Minovi
authors.forename: Andreas
authors.initials: A
authors.lastname: Hertel
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ural
authors.forename: Erich
authors.initials: E
authors.lastname: Hofmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Draf
authors.forename: Ulrike
authors.initials: U
authors.lastname: Bockmuehl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007013:Hypopharynx / Q000473:pathology; D007830:Larynx / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000473:pathology; D009367:Neoplasm Staging; D009960:Oropharynx / Q000473:pathology; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity