title: Antimitotic quinoid triterpenes from Maytenus chuchuhuasca.
abstract: Four cytotoxic quinoid triterpenes, tingenone (1), 22 beta-hydroxytingenone (2), pristimerin (3), and celastrol (4), isolated from Maytenus chuchuhuasca, potently inhibit the polymerization of tubulin.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Muto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014404:Tubulin / Q000187:drug effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D014404:Tubulin; C050414:celastrol