Complement-HIV interactions during all steps of viral pathogenesis.
Upon crossing the endothelial barrier of the host, HIV initiates immediate responses of the immunity system. Among its components, the complement system is one of the first the first elements, which are activated to affect HIV propagation. Complement participates not only in the early phase of the immune response, but its effects can be observed continuously and also concern the induction and modification of the adaptive immune response. Here we discuss the role of complement in early and late stages of HIV pathogenesis and review the escape mechanisms, which protect HIV from destruction by the complement system.
Stoiber
Heribert
H
Department of Hygiene, Microbiology & Social Medicine, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria. heribert.stoiber@i-med.ac.at
Banki
Zoltan
Z
Wilflingseder
Doris
D
Dierich
Manfred P
MP
D000706:Anaphylatoxins / Q000276:immunology; D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology / Q000821:virology; D009092:Mucous Membrane / Q000276:immunology / Q000821:virology; D009895:Opsonin Proteins / Q000276:immunology; D053585:Virus Attachment
D000706:Anaphylatoxins; D009895:Opsonin Proteins; D003165:Complement System Proteins