title: Diagnostic challenges of tuberculosis peritonitis in patients with and without end-stage renal failure.
abstract: BACKGROUND
  Information about diagnostic features of tuberculosis (TB) peritonitis among patients with end-stage renal failure (ESRF), compared with those without ESRF, is limited. Here, we review our experience with TB peritonitis in patients with and without ESRF over a period of 11 years, with special reference to the clinical features of and diagnostic tools for TB peritonitis.
  
  
  METHODS
  The records of all patients with TB peritonitis who were seen at United Christian Hospital (Hong Kong) from 1996 through 2006 were reviewed. The diagnosis of TB peritonitis was based on (1) detection of mycobacteria on smear and/or Mycobacterium tuberculosis on culture of ascitic fluid and/or peritoneal biopsy specimens and/or (2) demonstration of caseating granulomata on histological assessment of peritoneal biopsy specimens.
  
  
  RESULTS
  During the study period, 52 patients (19 without ESRF and 33 with ESRF) had TB peritonitis. Patients with ESRF tended to have more-acute onset of symptoms and neutrophil-predominant peritoneal fluid, which mimicked bacterial peritonitis. Diagnosis was made earlier among patients without ESRF than among those with ESRF. Laparotomy or laparoscopy was the initial diagnostic tool for 12 patients (63%) without ESRF, whereas mycobacterial culture was the diagnostic method for 18 patients (55%) with ESRF.
  
  
  CONCLUSIONS
  TB peritonitis has nonspecific and protean manifestations. It should be considered in the context of culture-negative peritonitis and in the context of culture-positive peritonitis that fails to respond to appropriate antibiotics. Laparoscopy with biopsy should be considered at an early stage when TB peritonitis is suspected.
authors.affiliation: Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong Kong Special Administrative Region, People's Republic of China. chautainin@hotmail.com
authors.forename: Tai Nin
authors.initials: TN
authors.lastname: Chau
authors.forename: Vincent King Sun
authors.initials: VK
authors.lastname: Leung
authors.forename: Sunny
authors.initials: S
authors.lastname: Wong
authors.forename: Siu Tong
authors.initials: ST
authors.lastname: Law
authors.forename: Wai Hong
authors.initials: WH
authors.lastname: Chan
authors.forename: Ivy Sheung Ching
authors.initials: IS
authors.lastname: Luk
authors.forename: Wei Kwang
authors.initials: WK
authors.lastname: Luk
authors.forename: Siu Ho
authors.initials: SH
authors.lastname: Lam
authors.forename: Yiu Wing
authors.initials: YW
authors.lastname: Ho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D014395:Peritonitis, Tuberculous / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D012189:Retrospective Studies