Predictors of antimicrobial-resistant Escherichia coli in the feces of vegetarians and newly hospitalized adults in Minnesota and Wisconsin.
To determine whether poultry contact/consumption predicts colonization with antimicrobial-resistant Escherichia coli, 567 newly hospitalized patients and 100 vegetarians were assessed microbiologically and epidemiologically. Multivariable analysis showed that poultry contact/consumption, other dietary habits, and antimicrobial use did not significantly predict resistance. In contrast, foreign travel significantly predicted both trimethoprim-sulfamethoxazole resistance (prevalence ratio, 2.7 [95% confidence interval, 1.3-5.6]) and "any resistance" (total population), whereas intensive-care-unit exposure predicted any resistance (hospital patients). Thus, most of the individual-level exposures-including poultry contact/consumption-that had been expected to be significant risk factors for infection with antimicrobial-resistant E. coli did not prove to be such. Other exposures, including household-, community-, and population-level effects, may be more important.
Sannes
Mark R
MR
Infectious Diseases Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
Belongia
Edward A
EA
Kieke
Burney
B
Smith
Kirk
K
Kieke
Amy
A
Vandermause
Mary
M
Bender
Jeff
J
Clabots
Connie
C
Winokur
Patricia
P
Johnson
James R
JR
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D014676:Diet, Vegetarian / Q000009:adverse effects*; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification*; D005243:Feces / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008910:Minnesota; D013419:Sulfamethizole / Q000494:pharmacology; D014195:Travel; D014295:Trimethoprim / Q000494:pharmacology; D014922:Wisconsin; D000096926:Benzenesulfonamides
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013419:Sulfamethizole; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides