title: Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea.
abstract: We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Severance Chilfren's Hospital, Seoul, South Korea. dskim6634@yumc.yonsei.ac.kr
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Taek Jin
authors.initials: TJ
authors.lastname: Lee
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Ma
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Hwang Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Son Mun
authors.initials: SM
authors.lastname: Shin
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007723:Korea; D016865:Reassortant Viruses / Q000276:immunology*; D012401:Rotavirus / Q000276:immunology; D022243:Rotavirus Vaccines / Q000009:adverse effects* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D022243:Rotavirus Vaccines; C058442:WC3 rotavirus vaccine