Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very-low-birthweight infants.
This study examined the developmental and clinical outcomes in very-low-birthweight (VLBW; < or =1500g) infants with and without bronchopulmonary dysplasia (BPD) throughout infancy, and assessed if BPD predicted poor developmental outcome beyond the effects of other risk factors. One hundred and three VLBW infants (53 males, 50 females; mean gestational age 28wks [SD 2] birthweight 1041g [SD 261]) were graded for severity of BPD according to the American National Institutes of Health (NIH) consensus definition. Neuro-development was assessed using the Neonatal Neurobehavioral Examination-Chinese version, at 36 and 39 weeks' postmenstrual age, and the 2nd edition of the Bayley Scales of Infant Development at 6 and 12 months' corrected age. Clinical outcome was measured by means of rehospitalization for pulmonary causes and treatment with pulmonary medications. Compared with infants without BPD, infants with BPD had higher rates of clinical morbidity, and those with severe BPD further exhibited higher incidences of developmental delay throughout infancy. BPD predicts poor 1-year developmental and clinical outcomes in VLBW infants for which effects are well correlated to the NIH consensus definition.
Jeng
Suh-Fang
SF
School of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsu
Chyong-Hsin
CH
Tsao
Po-Nien
PN
Chou
Hung-Chieh
HC
Lee
Wang-Tso
WT
Kao
Hsin-An
HA
Hung
Han-Yang
HY
Chang
Jui-Hsing
JH
Chiu
Nan-Chang
NC
Hsieh
Wu-Shiun
WS
D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index