Update on pemphigus treatment: present and future.
The life-saving management of pemphigus requires extended use of systemic therapies. Presently, there is no standard treatment for pemphigus, and each therapeutic approach carries potential benefits and risks. Recently published trials evaluating various treatment regimens better define the efficacy of these modalities, but fail to identify one protocol as clearly superior. Meanwhile, advances in understanding the role of p38MAPK in pemphigus may be leading to innovative new therapies.
Brownell
Isaac
I
D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D010392:Pemphigus / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors
D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D047428:Protein Kinase Inhibitors; D048051:p38 Mitogen-Activated Protein Kinases