title: The Met tyrosine kinase receptor in development and cancer.
abstract: Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met.
authors.affiliation: Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo (Torino), Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gentile
authors.forename: Livio
authors.initials: L
authors.lastname: Trusolino
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Comoglio
mesh_terms: D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D019859:Proto-Oncogene Proteins c-met / Q000502:physiology*
chemical_list: D019859:Proto-Oncogene Proteins c-met