title: Investigation of a flexible enantiospecific approach to aziridines.
abstract: A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, United Kingdom.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Jamookeeah
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Beadle
authors.forename: Richard F W
authors.initials: RF
authors.lastname: Jackson
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity
mesh_terms: D000478:Alkylation; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D003300:Copper