title: Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome.
abstract: OBJECTIVE
  Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome.
  
  
  METHODS
  In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively).
  
  
  RESULTS
  Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0.001) and correlated with serum total protein (r = -0.549, p < 0.001), serum albumin (r = -0.596, p < 0.001), proteinuria (r = 0.456, p < 0.001) and serum total cholesterol (r = 0.523, p < 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p < 0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p < 0.001), serum albumin (r = -0.615, p < 0.001), proteinuria (r = 0.694, p < 0.001), and serum total cholesterol (r = 0.723, p < 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2.
  
  
  CONCLUSIONS
  These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.
authors.affiliation: 2nd Department of Medicine and Nephrological Center, Faculty of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Márton
authors.initials: M
authors.lastname: Mohás
authors.forename: Nóra
authors.initials: N
authors.lastname: Szigeti
authors.forename: Lajos
authors.initials: L
authors.lastname: Markó
authors.forename: Gergo A
authors.initials: GA
authors.lastname: Molnár
authors.forename: Judit
authors.initials: J
authors.lastname: Cseh
authors.forename: Boglárka
authors.initials: B
authors.lastname: Laczy
authors.forename: Mónika
authors.initials: M
authors.lastname: Tamaskó
authors.forename: József
authors.initials: J
authors.lastname: Balla
authors.forename: János
authors.initials: J
authors.lastname: Kappelmayer
authors.forename: László
authors.initials: L
authors.lastname: Wagner
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Wagner
authors.forename: Botond
authors.initials: B
authors.lastname: Csiky
authors.forename: Judit
authors.initials: J
authors.lastname: Nagy
authors.forename: István
authors.initials: I
authors.lastname: Wittmann
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000201:enzymology* / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C409676:lactate dehydrogenase 2