Cyclosporine induced neurotoxicity in a stem cell transplant recipient.
Neurological complications are quite frequent in stem cell transplant (SCT) recipients. Major causes are conditioning regimen toxicity, metabolic and electrolyte disturbances, viral infections and cyclosporine related toxicity. Cyclosporine induced neurotoxicity is a well documented complication in stem cell transplant recipients. These patients usually present with seizures which are easily controlled with anti-convulsants and by reducing/withholding the drug. However uncontrolled seizures requiring ventilatory support are rarely reported. Here we present a case report of cyclosporine induced uncontrolled seizures in a young female after allogeneic SCT which was unresponsive to anti-convulsive therapy but was successfully treated with mechanical ventilatory support.
Raza
Shahid
S
Armed Forces Bone Marrow Transplant Centre, Rawalpindi.
Ullah
Khalil
K
Ahmed
Parvez
P
Satti
Tariq Mahmood
TM
Kamal
Muhammad Khalid
MK
Chaudhry
Qamar-un-Nisa
QU
D000328:Adult; D000741:Anemia, Aplastic; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells; D014180:Transplantation; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine