Results following surgical resection for malignant pancreatic neuroendocrine tumours. A single institutional experience.
OBJECTIVE
The aim of the study was to present clinical outcomes of patients with malignant pancreatic neuroendocrine tumours (NET) following surgical resection with curative intent. Clinical and pathological factors that influenced the outcomes were also analysed.


METHODS
Retrospective case note study.


METHODS
All patients with pancreatic NET that underwent surgery over a 7-year period (1999-2006).


RESULTS
Twelve patients were identified with a median age at diagnosis of 54 years (range: 24-79 years). Common presenting symptoms include abdominal pain (n=8) and weight loss (n=3). Overall morbidity was 25% with one post-operative death. The median follow-up period was 41 months (range: 9-156 months). The overall 2- and 5-year actuarial survival rates were 88% and 70%, respectively. The overall survival was better in patients treated with surgery compared to patients managed medically (P<0.001). The disease-free survival rates were 62% at 2 and 5 years, respectively. Recurrent disease occurred in four patients and the median disease-free interval was 6 months (range: 3-14 months). On univariate analysis, angio-invasion (P=0.015) and degree of differentiation (P=0.024) were associated with developing recurrent disease.


CONCLUSIONS
Surgical resection of malignant pancreatic NET results in good long-term survival in selected patients.
Bonney
Glenn K
GK
Department of HPB and Transplantation, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
Gomez
Dhanwant
D
Rahman
Sakwhat H
SH
Verbeke
Caroline S
CS
Prasad
K Raj
KR
Toogood
Giles J
GJ
Lodge
J Peter A
JP
Menon
Krishna V
KV
D000328:Adult; D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome