Negligible effect of non-ionic radiocontrast medium exposure on microalbuminuria in patients undergoing coronary angiography.
Contrast-induced nephropathy (CIN) remains one of the most common hospital-acquired acute renal deterioration in patients undergoing angiographic procedure. Transient and massive non-selective proteinuria of glomerular origin was previously reported in patients with stable renal function shortly after ionic radiocontrast medium (RCM) exposure. Since non-ionic RCM is mostly used nowadays for coronary angiographic procedures, the effects of non-ionic RCM exposure on microalbuminuria might be worthy to be clarified. By measuring urine albumin-creatinine-ratio, we found that exposure to non-ionic, low osmolar RCM has almost negligible effect on either the presence or the levels of microalbuminuria in patients who underwent coronary angiography using ordinary dose. The findings of neutral effect of non-ionic RCM on microalbuminuria in our study might offer another rationale in an effort to prevent CIN. Further large-scaled clinical trials in delineating the effects on microalbuminuria after non-ionic RCM exposure were warranted, particularly in those with pre-existing renal insufficiency, to clarify the clinical implications of our study results.
Chu
Chih-Sheng
CS
Cheng
Kai-Hong
KH
Lee
Kun-Tai
KT
Lin
Tsung-Hsien
TH
Voon
Wen-Chol
WC
Tsai
Li-Yu
LY
Sheu
Sheng-Hsiung
SH
Lai
Wen-Ter
WT
D000419:Albuminuria / Q000139:chemically induced / Q000652:urine*; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*
D003287:Contrast Media