title: Cytotoxic constituents from the leaves of Cinnamomum subavenium.
abstract: Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1-3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose- and time-dependent manner.
authors.affiliation: School of Medicine and Health Sciences, Fooyin University, Taiwan.
authors.forename: Soong-Yu
authors.initials: SY
authors.lastname: Kuo
authors.forename: Tian-Jye
authors.initials: TJ
authors.lastname: Hsieh
authors.forename: Yau-Der
authors.initials: YD
authors.lastname: Wang
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Lo
authors.forename: Yen-Ray
authors.initials: YR
authors.lastname: Hsui
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D027424:Cinnamomum / Q000737:chemistry*; D004249:DNA Damage; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C525771:secosubamolide A; C525769:subamolide D; C525770:subamolide E; D015107:4-Butyrolactone