title: Synthesis, degradability, and cell affinity of poly (DL-lactide-co-RS-hydroxyethyl-beta-malolactonate).
abstract: Poly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate) (PLMAH), a novel functionalized polylactide with hydroxyl arms, was synthesized by a two-step reaction. DL-lactide (DLLA) and RS-benzyloxyethyl-beta-malolactonate were first copolymerized by ring-opening polymerization with Sn(Oct)(2) as catalyst to generate poly(DL-lactide-co-RS-benzyloxyethyl-beta-malolactonate) (PLMAB); next the benzyl protective groups of PLMAB were removed by the hydrogenation reaction catalyzed by Pd/C to generate the final polymer PLMAH. The composition and structure of PLMAB and PLMAH were characterized by (1)H and (13)C NMR. In vitro degradation experiments of PLMAH copolymers showed that the more RS-hydroxyethyl-beta-malolactonate (MAHE) content in the copolymer film, the faster the degradation occurred. The results of human umbilical vein endothelial cells (ECV-304) cultivated on PDLLA and PLMAH films suggested that among all the films, the PLMAH film containing 9.4 mol % MAHE had the highest cell attachment efficiency.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Jia
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Che
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D002460:Cell Line; D048430:Cell Shape; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D015394:Molecular Structure; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C533715:poly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate); D014867:Water; C033616:poly(lactide)