title: Intervention in necrotizing pancreatitis: an evidence-based review of surgical and percutaneous alternatives.
abstract: Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.
authors.affiliation: Department of Clinical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA. ed.bradley@med.fsu.edu
authors.forename: Edward L
authors.initials: EL
authors.lastname: Bradley
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Howard
authors.forename: Eric
authors.initials: E
authors.lastname: van Sonnenberg
authors.forename: Mehran
authors.initials: M
authors.lastname: Fotoohi
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019317:Evidence-Based Medicine; D007261:Infusions, Intra-Arterial; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010447:Peptide Hydrolases / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D010447:Peptide Hydrolases