Hibernoma-like brown fat in the bone marrow: report of a unique case.
We report on a bone-marrow biopsy of a 61-year-old female patient that was performed because of the clinical suspicion of a myeloproliferative disease. The trephine biopsy showed morphological features that were consistent with an essential thrombocythaemia (ET). The diagnosis of a myeloproliferative disease could be corroborated by demonstration of the V617F mutation of JAK2. Besides the histological features of ET, the marrow showed a peculiar infiltrate that consisted of multivacuolated cells that were immunohistochemically identified as brown adipose tissue with a hibernoma-like picture. To the best of our knowledge, this is the first report on brown adipose tissue in the bone marrow.
Thorns
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C
Institut für Pathologie und Konsultations-und Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. thorns@patho.uni-luebeck.de
Schardt
C
C
Katenkamp
D
D
Kähler
C
C
Merz
H
H
Feller
A C
AC
D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000473:pathology*; D019943:Amino Acid Substitution; D001706:Biopsy; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053614:Janus Kinase 2 / Q000235:genetics; D008067:Lipoma / Q000473:pathology*; D008875:Middle Aged; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000097:blood / Q000473:pathology; D013922:Thrombocytosis / Q000097:blood / Q000473:pathology
C507924:JAK2 protein, human; D053614:Janus Kinase 2