Osteogenic activity of the mixture of chitosan and particulate dentin.
To evaluate the healing effect of a mixture of chitosan and particulate dentin, a 8-mm-diameter critical size defect was created in the calvarium of 75 rats. The rats were divided into four experimental groups and a control group (no treatment). The defects in the experimental groups were grafted either with pig particulate dentin (group 1), a mixture of particulate dentin and plaster of Paris (group 2), particulate dentin and chitosan (group 3), or chitosan only (group 4). Rats in each group were sacrificed 2, 4, and 8 weeks after implantation. All experimental groups showed more new bone formation when compared to the control group. Additionally, all groups exhibited more bone growth at 8 weeks than at 4 weeks after implantation. It was concluded from this study that defects treated with particulate dentin powder-chitosan mixture may mediate an excellent effect on the formation of new bones.
Park
Sun-Sik
SS
Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University, Gwangju, Korea.
Kim
Su-Gwan
SG
Lim
Sung-Chul
SC
Ong
Joo L
JL
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002133:Calcium Sulfate / Q000627:therapeutic use*; D048271:Chitosan / Q000494:pharmacology*; D003804:Dentin / Q000737:chemistry*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000293:injuries; D014945:Wound Healing
D018786:Bone Substitutes; D048271:Chitosan; D002133:Calcium Sulfate