Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma.
Hepatic veno-occlusive disease (HVOD) is one of the major potential complications associated with high-dose chemotherapy with stem cell transplantation in children. However, esophageal varix rupture after HVOD has, to our knowledge, never been reported before. Here we report a case of a 4-year-old boy with stage 4 neuroblastoma with potentially fatal HVOD followed by esophageal varix rupture and massive intestinal bleeding after high-dose chemotherapy with autologous peripheral blood stem cell transplantation. We successfully treated him by endoscopic variceal ligation and administration of somatostatin analog.
Kajiwara
Ryosuke
R
Department of Pediatrics, Yokohama City University Hospital, Kanagawa, Japan. kajikaji119@hotmail.com
Goto
Hiroaki
H
Yokosuka
Tomoko
T
Yanagimachi
Masakatsu
M
Kuroki
Fumiko
F
Yokota
Shumpei
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D002675:Child, Preschool; D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006728:Hormones / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012422:Rupture, Spontaneous / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013004:Somatostatin / Q000008:administration & dosage / Q000031:analogs & derivatives; D014182:Transplantation, Autologous
D006728:Hormones; D013004:Somatostatin