title: Limonoids from the root of Dictamnus radicis cortex.
abstract: Chemical investigation of the roots of Dictamnus radicis Cortex led to the isolation of a new limonoid isodictamdiol (1) and a known dictamdiol (2), the first 5S/9S-type degraded limonoids, together with other six known limonoids (3-8). The chemical structures were identified on the basis of modern spectroscopic methods, including IR, MS, NMR ((1)H-NMR, (13)C-NMR, (1)H-(1)H COSY, HMQC, HMBC, NOESY). Additionally, the absolute configurations of limonoid isodictamdiol (1) and dictamdiol (2) were separately elucidated by single crystal X-ray diffraction, as well as their circular dichroism spectra. Furthermore, all compounds were evaluated for antibacterial activity against three bacterial cultures.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, People's Republic of China.
authors.forename: Pei Hua
authors.initials: PH
authors.lastname: Zhao
authors.forename: Li Mei
authors.initials: LM
authors.lastname: Sun
authors.forename: Xiu Jin
authors.initials: XJ
authors.lastname: Liu
authors.forename: Mei Ai
authors.initials: MA
authors.lastname: Cao
authors.forename: Cheng Shan
authors.initials: CS
authors.lastname: Yuan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D036905:Dictamnus / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D036701:Limonins