title: Pneumococcal conjugate vaccine does not influence Staphylococcus aureus carriage in young children with acute otitis media.
abstract: We investigated nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus among infants and young children with acute otitis media in a country where use of 7-valent pneumococcal conjugate vaccine (PCV7) has been progressively implemented. Among 1783 children enrolled, 60.8% carried S. pneumoniae, and 9% carried S. aureus. Among S. pneumoniae carriers, the rate of S. aureus carriage was 8.4%, compared with 9.9% among S. pneumoniae noncarriers. The rate of S. pneumoniae carriage in the PCV7-vaccinated population was lower (59.8%) than that observed in the nonvaccinated population (66.2%; P<.04). In contrast, in young children (age, <2 years) with acute otitis media, our study suggests that the S. aureus carriage rate is not affected by PCV7 immunization (9.0% in vaccinated children vs. 8.7% in nonvaccinated children). Furthermore, in children aged >1 year, the booster dose induces a sharp reduction in the carriage of vaccine serotypes of S. pneumoniae, without any change in S. aureus carriage.
authors.affiliation: Service de Microbiologie, Centre Hospitalier Intercommunal de Creteil, Creteil, France. robert.cohen@wanadoo.fr
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Franck
authors.initials: F
authors.lastname: Thollot
authors.forename: France
authors.initials: F
authors.lastname: de La Rocque
authors.forename: Marc
authors.initials: M
authors.lastname: Koskas
authors.forename: Eric
authors.initials: E
authors.lastname: Bonnet
authors.forename: Bernard
authors.initials: B
authors.lastname: Fritzell
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Varon
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines; D010033:Otitis Media / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines; D011446:Prospective Studies; D012307:Risk Factors; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines