Ionically cross-linked carrageenan-alginate hydrogel beads.
Hydrogel beads based on the carbohydrate biopolymers kappa-carrageenan and sodium alginate were newly prepared. Both classical and experimental design (Taguchi) methods were used to obtain the optimum conditions for the full-polysaccharide hydrogel preparation. The carrageenan-alginate (Caralgi) beads exhibited a surface morphology smoother than that of the one-polysaccharide network beads. Infrared spectroscopy and DSC/TGA thermal methods were used to study the chemical structure and thermal properties of the beads. The carrageenan parts appreciably enhanced thermostability of the networks. The fully carbohydrate-based hydrogel beads are expected to be biologically compatible and degradable. They are being considered as new carriers for drug loading and controlled delivery systems.
Mohamadnia
Z
Z
Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran.
Zohuriaan-Mehr
M J
MJ
Kabiri
K
K
Jamshidi
A
A
Mobedi
H
H
D000464:Alginates / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002351:Carrageenan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011189:Potassium Chloride / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry
D000464:Alginates; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020100:Hydrogels; D007477:Ions; D011189:Potassium Chloride; D020723:Glucuronic Acid; D002351:Carrageenan; D002122:Calcium Chloride