title: The changing patterns of bladder cancer in Egypt over the past 26 years.
abstract: OBJECTIVE
  To evaluate temporal changes in histopathological types of bladder cancer and to assess associated changes in demographic, epidemiologic, and lifestyle risk factors.
  
  
  METHODS
  We abstracted data from all available medical records from the National Cancer Institute of Cairo University (NCI-Cairo). Six calendar years representing 5-year periods between 1980 and 2005 were evaluated. Information on demographics, schistosomal infection, clinical symptoms of bladder cancer, and tumor pathology was abstracted.
  
  
  RESULTS
  During this 26-year period, important changes in the frequency of histopathological types of bladder cancer occurred. We found a statistically significant association between time period of diagnosis and histopathological type. Patients diagnosed in 2005 had a sixfold higher odds associated with transitional cell carcinoma compared to those patients diagnosed in 1980 (odds ratio (OR) 6.00 (95% CI 4.00-8.97)).
  
  
  CONCLUSIONS
  These data strongly suggest that the histopathological profile of bladder cancer in Egypt has changed significantly over the past 26 years. Historically, squamous cell carcinoma was the predominant form of bladder cancer in Egypt; however transitional cell carcinoma has become the most frequent type. These results corroborate findings from a few small-scale hospital-based studies which conclude that the etiology of bladder cancer in Egypt has changed significantly over the past 26 years.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, 109 S. Observatory, Ann Arbor, MI 48109, USA.
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Felix
authors.forename: Amr S
authors.initials: AS
authors.lastname: Soliman
authors.forename: Hussein
authors.initials: H
authors.lastname: Khaled
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Zaghloul
authors.forename: Mousumi
authors.initials: M
authors.lastname: Banerjee
authors.forename: Manal
authors.initials: M
authors.lastname: El-Baradie
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Kalawy
authors.forename: Alaa A
authors.initials: AA
authors.lastname: Abd-Elsayed
authors.forename: Kadry
authors.initials: K
authors.lastname: Ismail
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hablas
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Seifeldin
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ramadan
authors.forename: Mark L
authors.initials: ML
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012553:Schistosomiasis haematobia / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*