title: Successful multimodal treatment in a patient with thymoma accompanied by hepatic metastasis.
abstract: Despite a benign histologic appearance, thymomas have metastatic potential. Here we report a case of a patient with a Masaoka stage IVb thymoma who was successfully treated using a multimodal strategy including systemic chemotherapy, radiofrequency ablation, and thoracic surgery. Despite complete remission after treatment, the patient developed myasthenia gravis with ptosis and neck drop symptoms. Hepatic metastasis of thymoma is a relatively rare occurrence and, to the best of our knowledge, this is the first report about the application of radiofrequency ablation to thymoma.
authors.affiliation: Department of Internal Medicine, Osaka Saiseikai Senri Hospital, Osaka, Japan. shoshino@senri.saiseikai.or.jp
authors.forename: Shigenori
authors.initials: S
authors.lastname: Hoshino
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Furukawa
authors.forename: Kazumi
authors.initials: K
authors.lastname: Aragane
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Horimoto
authors.forename: Kunio
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shiono
authors.forename: Masato
authors.initials: M
authors.lastname: Minami
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kijima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawase
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001707:Biopsy, Needle; D017115:Catheter Ablation / Q000379:methods; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000473:pathology; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D013934:Thymectomy; D013945:Thymoma / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D002945:Cisplatin