title: Effect of 1,25(OH)2-vitamin D on bone mass in children with acute lymphoblastic leukemia.
abstract: BACKGROUND
  Calcitriol deficit has been described in patients with acute lymphoblast leukemia (ALL). The aim of this randomized case-control trial is to investigate the effectiveness of calcitriol administration during the first year of treatment to protect bone mass. Sixteen children recently diagnosed with ALL, aged 1.7 to 11.5 years, average 5.5, completed the study. Anthropometrical measurements, food intake record, physical activity, and bone pain were registered. Dual energy x-ray absorptiometry was performed at the completion of remission induction chemotherapy (after 1 mo) to measure bone mineral density (BMD) at hip, lumbar spine and whole body, and total bone mineral content and 1 year after. Half of them were randomly assigned to receive calcitriol during 1 year.
  
  
  METHODS
  Kruskal-Wallis, Wilcoxon, Mann-Whitney, and Spearman.
  
  
  RESULTS
  Both groups had similar anthropometric measurements and bone densitometric variables increments. Spine BMD significantly increased in calcitriol supplemented children with lower baseline BMD (r=-0.78 and P<0.05).
  
  
  CONCLUSIONS
  One-year calcitriol administered to recently diagnosed ALL children did not show impact on bone mass. Greater increment in lumbar spine bone mass was observed in patients who received calcitriol and had lower baseline BMD.
authors.affiliation: Pediatric Hemato-Oncology Department, Viña del Mar School of Medicine, University of Valparaíso, Chile.
authors.forename: Paulina R
authors.initials: PR
authors.lastname: Díaz
authors.forename: Laura C
authors.initials: LC
authors.lastname: Neira
authors.forename: Sylvia G
authors.initials: SG
authors.lastname: Fischer
authors.forename: María C
authors.initials: MC
authors.lastname: Teresa Torres
authors.forename: Aída T
authors.initials: AT
authors.lastname: Milinarsky
authors.forename: Vinka R
authors.initials: VR
authors.lastname: Giadrosich
authors.forename: Marina M
authors.initials: MM
authors.lastname: Arriagada
authors.forename: Roberto S
authors.initials: RS
authors.lastname: Arinoviche
authors.forename: Dunny M
authors.initials: DM
authors.lastname: Casanova
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002117:Calcitriol / Q000008:administration & dosage* / Q000172:deficiency*; D002648:Child; D002675:Child, Preschool; D004435:Eating / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D014808:Vitamin D Deficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D050071:Bone Density Conservation Agents; D002117:Calcitriol