Removal of the skin blood flow artifact in functional near-infrared spectroscopic imaging data through independent component analysis.
We investigate whether the functional near-infrared spectroscopic (fNIRS) signal includes a signal from the changing skin blood flow. During a locomotor task on a treadmill, changes in the hemodynamic response in the front-parietal area of healthy human subjects are simultaneously recorded using an fNIRS imaging system and a laser Doppler tissue blood flow meter. Independent component analysis (ICA) for fNIRS signals is performed. The skin blood flow changes during locomotor tasks on a treadmill. The activated spatial distribution of one of the components separated by ICA reveals an overall increase in fNIRS channels. To evaluate the uniformity of the activated spatial distribution, we define a new statistical value-the coefficient of spatial uniformity (CSU). The CSU value is a highly discriminating value (e.g., 2.82) compared with values of other components (e.g., 1.41, 1.10, 0.96, 0.61, and 0.58). In addition, the independent component signal corresponding to the activated spatial distribution is similar to changes in skin blood flow measured with the laser Doppler tissue blood flow meter. The coefficient of correlation indicates strong correlation. Localized activation areas around the premotor and medial somatosensory cortices are shown more clearly by eliminating the extracted component.
Kohno
Satoru
S
Shimadzu Corporation, Medical Systems Division, Research and Development Department, Kyoto 604-8511, Japan. satoro@shimadzu.co.jp
Miyai
Ichiro
I
Seiyama
Akitoshi
A
Oda
Ichiro
I
Ishikawa
Akihiro
A
Tsuneishi
Shoichi
S
Amita
Takashi
T
Shimizu
Koji
K
D000465:Algorithms; D001783:Blood Flow Velocity; D003627:Data Interpretation, Statistical; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D012815:Signal Processing, Computer-Assisted; D012867:Skin / Q000098:blood supply*; D019265:Spectroscopy, Near-Infrared / Q000379:methods* / Q000706:statistics & numerical data
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen