Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine.
The present investigation demonstrates the hepatoprotective potential of 50% ethanolic water extract of whole plant of Fumaria indica and its three fractions viz., hexane, chloroform and butanol against d-galactosamine induced hepatotoxicity in rats. The hepatoprotection was assessed in terms reduction in histological damage, changes in serum enzymes (SGOT, SGPT, ALP) and metabolites bilirubin, reduced glutathione (GSH) and lipid peroxidation (MDA content). Among fractions more than 90% protection was found with butanol fraction in which alkaloid protopine was quantified as highest i.e. about 0.2mg/g by HPTLC. The isolated protopine in doses of 10-20mg p.o. also proved equally effective hepatoprotectants as standard drug silymarine (single dose 25mg p.o.). In general all treatments excluding hexane fraction proved hepatoprotective at par with silymarine (p<or=0.01).
Rathi
Anshu
A
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, India. anshurathi@rediffmail.com
Srivastava
Arvind Kumar
AK
Shirwaikar
Annie
A
Singh Rawat
Ajay Kumar
AK
Mehrotra
Shanta
S
D000818:Animals; D053119:Benzophenanthridines / Q000302:isolation & purification / Q000627:therapeutic use*; D001600:Berberine Alkaloids / Q000302:isolation & purification / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D002851:Chromatography, High Pressure Liquid; D031312:Fumaria / Q000737:chemistry*; D005688:Galactosamine; D008099:Liver / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D010936:Plant Extracts; D005688:Galactosamine; C009093:protopine