title: Endovascular treatment of aortic coarctation: long-term effects on hypertension.
abstract: BACKGROUND
  Endovascular management of aortic coarctation (CoA) is safe but few data are available concerning the long-term cure of hypertension. Aim of this study was to evaluate immediate and long-term clinical and haemodynamic outcome in a consecutive series of adolescent and adult patients with CoA submitted to endovascular treatment.
  
  
  METHODS
  A total of 21 adolescent and adult patients underwent successful transcatheter intervention of CoA. Follow-up comprised cardiological examination with special attention to blood pressure (BP), echocardiogram, 24/h ambulatory blood pressure monitoring (ABP), exercise test and spiral computed tomography.
  
  
  RESULTS
  Pre-intervention CoA diameter and degree of stenosis were 4.8+/-2.1 mm and 73.7+/-9.8%, respectively, and 14.8+/-3.0 mm and 13.5+/-6.5% post-intervention (p<0.001). Systolic arterial hypertension persisted in 2 patients at rest (9.5%). Mean number of antihypertensive medications per patient was 1.5+/-1.1 and 0.5+/-0.9 at 1 year after treatment (p<0.05). At ABP 3 patients (14%) were hypertensive. The Doppler gradient across the coarctation site decreased from 58.8+/-16.9 to 10.5+/-4.9 mmHg (p<0.001) as well as left ventricular mass (199+/-14.6 and 189.3+/-9.1; p<0.001). Overall, 18 patients (86%) underwent a treadmill exercise test and 4 patients (22%), normotensive at rest, showed a pathological blood pressure response. Overall, 7/21 patients (33%) showed persistent hypertension.
  
  
  CONCLUSIONS
  Endovascular treatment of native or recurrent CoA in adolescent and adult patients is safe but 33% of patients showed persistent hypertension. Meticulous clinical follow-up is mandatory, including an exercise test in order to monitor eventual blood pressure increase and to assess effort tolerance.
authors.affiliation: Interventional Cardiology Unit, S. Camillo/Forlanini Hospital, Circonvallazione Gianicolense, 87, 00151 Rome, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Musto
authors.forename: Alberta
authors.initials: A
authors.lastname: Cifarelli
authors.forename: Edoardo
authors.initials: E
authors.lastname: Pucci
authors.forename: Serena
authors.initials: S
authors.lastname: Paladini
authors.forename: Francesco
authors.initials: F
authors.lastname: De Felice
authors.forename: Rosario
authors.initials: R
authors.lastname: Fiorilli
authors.forename: Roberto
authors.initials: R
authors.lastname: Violini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001017:Aortic Coarctation / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D001794:Blood Pressure; D002648:Child; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015607:Stents; D036542:Tomography, Spiral Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents