Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide.
Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.
Yayama
Katsutoshi
K
Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University, Minatojima 1-1-3, Chuo-ku, Kobe 650-8586, Japan.
Okamoto
Hiroshi
H
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000502:physiology*; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D044139:Receptor, Angiotensin, Type 2 / Q000502:physiology*; D015398:Signal Transduction; D015854:Up-Regulation; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D044139:Receptor, Angiotensin, Type 2; D000804:Angiotensin II; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; D001920:Bradykinin