title: Depressed mood during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study.
abstract: OBJECTIVE
  To characterize patterns of depressed mood during the menopausal transition (MT) in relation to age and MT-related factors and to assess the contribution of factors related to depressed mood at earlier points in the life span.
  
  
  METHODS
  Women (N = 508) were recruited from 1990 to 1992 from multiethnic neighborhoods and followed annually through 2005: 302 met the eligibility criteria for analyses reported here. The Center for Epidemiologic Studies Depression scale (CES-D) and a menstrual calendar were completed annually throughout the study. A subset of women provided a first morning voided urine specimen from 1997 through 2005. Urine samples were assayed for estrone glucuronide, follicle-stimulating hormone, testosterone, and cortisol. Mixed effects modeling was used to identify changes in CES-D scores over time, including the relationship to age, MT-related factors, and factors related to depression at other points in the life span (postpartum depression/blues, life stress, or family history of clinical depression).
  
  
  RESULTS
  Age was modestly and negatively related to CES-D scores, but MT stage alone was not, except that the late MT stage was significantly related to depressed mood. Hot flash activity, life stress, family history of depression, history of "postpartum blues," sexual abuse history, body mass index, and use of antidepressants were also individually related to depressed mood; the hormonal assays and age of entry into and duration of late MT stage were unrelated.
  
  
  CONCLUSIONS
  Although women in the late MT stage are vulnerable to depressed mood, factors that account for depressed mood earlier in the life span continue to have an important influence and should be considered in studies of etiology and therapeutics.
authors.affiliation: Department of Family and Child Nursing, University of Seattle, WA 98195-7260, USA. nfwoods@u-washington.edu
authors.forename: Nancy Fugate
authors.initials: NF
authors.lastname: Woods
authors.forename: Kathleen
authors.initials: K
authors.lastname: Smith-DiJulio
authors.forename: Donald B
authors.initials: DB
authors.lastname: Percival
authors.forename: Eunice Y
authors.initials: EY
authors.lastname: Tao
authors.forename: Anne
authors.initials: A
authors.lastname: Mariella
authors.forename: Sullivan
authors.initials: S
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D000375:Aging / Q000523:psychology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D019584:Hot Flashes / Q000523:psychology; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008875:Middle Aged; D047648:Perimenopause / Q000502:physiology / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012742:Sex Offenses