title: Indexes of suspicion of typical cow's milk protein-induced enterocolitis.
abstract: This study was performed to identify clinical factors that facilitate the diagnosis of typical cow's milk protein-induced enterocolitis (CMPIE). Data from 142 consecutive patients (aged 15 to 45 days, cow's milk formula- or cow's milk and breast milk mixed-fed) admitted due to vomiting and/or diarrhea were retrospectively analyzed. These 142 subjects were divided into three groups: the CMPIE, infection, and non-infection group. Each group was composed of 16 (11.3%), 102 (71.8%), and 24 (16.9%) patients, respectively. On admission, poor weight gain (p=0.003), hypoalbuminemia (p=0.035), peripheral leukocytosis (p=0.012), and metabolic acidosis (p=0.015) were found to be more significant in the CMPIE group than those in other two groups. In CMPIE, serum albumin levels decreased from 3.3+/-0.9 g/dL on admission to 2.6+/-0.3 g/dL during admission (p<0.05), and methemoglobinemia was observed in 3 patients (18.8%) (p=0.012). Multiple logistic regression analysis showed that the independent predictors of CMPIE versus the infection group were failure to gain weight (OR, 10.75 [95% CI, 1.53-66.12]) (p= 0.014) and hypoalbuminemia (OR, 9.53 [95% CI, 1.62-49.01]) (p=0.010). The early recognition of indexes of suspicion for CMPIE may be of help in the diagnosis and treatment of this disorder.
authors.affiliation: Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. pedgi@korea.com
authors.forename: Jin Bok
authors.initials: JB
authors.lastname: Hwang
authors.forename: Sung Hyuk
authors.initials: SH
authors.lastname: Lee
authors.forename: Yu Na
authors.initials: YN
authors.lastname: Kang
authors.forename: Sang Pyo
authors.initials: SP
authors.lastname: Kim
authors.forename: Seong Il
authors.initials: SI
authors.lastname: Suh
authors.forename: Sin
authors.initials: S
authors.lastname: Kam
mesh_terms: D000138:Acidosis / Q000209:etiology; D000818:Animals; D002417:Cattle; D004760:Enterocolitis / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008708:Methemoglobinemia / Q000209:etiology; D016269:Milk Hypersensitivity / Q000175:diagnosis*; D008894:Milk Proteins / Q000276:immunology*; D012709:Serum Albumin / Q000032:analysis; D015430:Weight Gain
chemical_list: D008894:Milk Proteins; D012709:Serum Albumin