title: [Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia].
abstract: Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides. We encountered some MPO-ANCA positive patients with interstitial pneumonia who lacked vasculitides, but its meaning remains unclear. We measured MPO-ANCA titers in 69 patients with interstitial pneumonia (IP) who did not have collagen vascular diseases and observed their outcome. MPO-ANCA was positive in 5 patients and its prevalence was 7.2%. Patients with MPO-ANCA positive showed higher positivity in rheumatoid factor (RF) than patients with MPO-ANCA negative. The sensitivity and specificity of a combination of anti-nuclear antibody-negative and RF-positive were 80.0% and 87.7%, respectively. Two patients were accompanied by microscopic polyangiitis and the 3-year survival rate was 40% in all patients with MPO-ANCA. Measurement of MPO-ANCA titers in patients with IPs is meaningful for determining therapeutic strategy.
authors.affiliation: Department of Respiratory Medicine, Nagoya University Graduate School of Medicine.
authors.forename: Akira
authors.initials: A
authors.lastname: Shiraki
authors.forename: Morihide
authors.initials: M
authors.lastname: Ando
authors.forename: Joe
authors.initials: J
authors.lastname: Shindoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe
authors.forename: Keiko
authors.initials: K
authors.lastname: Wakahara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Makino
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Asano
authors.forename: Harunori
authors.initials: H
authors.lastname: Nakashima
authors.forename: Tetsunari
authors.initials: T
authors.lastname: Hase
authors.forename: Kikuo
authors.initials: K
authors.lastname: Shigemitsu
authors.forename: Michiaki
authors.initials: M
authors.lastname: Horiba
authors.forename: Kaoru
authors.initials: K
authors.lastname: Shimokata
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000276:immunology*; D008297:Male; D009195:Peroxidase / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase