title: Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
abstract: Three new erythrina alkaloids, (+)-10,11-dioxoerythratine (1), (+)-10,11-dioxoepierythratidine (2), and (+)-10,11-dioxoerythratidinone (3), and a new pterocarpan, 1-methoxyerythrabyssin II (4), were isolated from the bark of Erythrina subumbrans, together with seven known pterocarpans, erythrabyssin II, erybraedin A, erystagallin A, erycristagallin, erythrabissin-1, eryvarin A, and hydroxycristacarpone, three flavanones, 5-hydroxysophoranone, abyssinone V, and lespedezaflavanone B, three triterpenes, sophoradiol, soyasapogenol B, and lupeol, and one isoflavanone, vogelin C. Their structures were elucidated on the basis of spectroscopic data. Some isolates were tested for antiplasmodial, antimycobacterial, and cytotoxic activities.
authors.affiliation: Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. thitima@ru.ac.th
authors.forename: Thitima
authors.initials: T
authors.lastname: Rukachaisirikul
authors.forename: Phongsak
authors.initials: P
authors.lastname: Innok
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
chemical_list: C527624:1-methoxyerythrabyssin II; C527622:10,11-dioxoepierythratidine; C527623:10,11-dioxoerythratidinone; C527621:10,11-dioxoerythratine; D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D036343:Pterocarpans