Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome.
In 176 patients with Guillain-Barré syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C. jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome.
Jacobs
Bart C
BC
Department of Neurology, Erasmus MC, P.O. BOX 2040, 3000 CA Rotterdam, The Netherlands. b.jacobs@erasmusmc.nl
Koga
Michiaki
M
van Rijs
Wouter
W
Geleijns
Karin
K
van Doorn
Pieter A
PA
Willison
Hugh J
HJ
Yuki
Nobuhiro
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002169:Campylobacter Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D002648:Child; D003429:Cross Reactions; D018450:Disease Progression; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006192:Haemophilus Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry; D009046:Motor Neurons / Q000276:immunology*; D016032:Randomized Controlled Trials as Topic
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001323:Autoantibodies; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008070:Lipopolysaccharides