title: Changes in CCR2 chemokine receptor expression and plasma MCP-1 concentration after the implantation of bare metal stents versus sirolimus-eluting stents in patients with stable angina.
abstract: BACKGROUND
  Although restenosis after successful coronary stenting is associated with changes in adhesion molecules and chemokines, it is unclear whether the differential effects of these molecules between a bare metal stent (BMS) and sirolimus-eluting stent (SES) may help to prevent coronary restenosis. The aim of this clinical study was to compare the expression levels of those molecules after elective placement of either a BMS or SES.
  
  
  RESULTS
  The subjects included 32 consecutive patients with stable angina who had undergone successful coronary stenting and who randomly received either a BMS (n=16) or SES (n=16). Quantitative angiographic analysis 6 months after stenting showed that the minimal lumen diameter was significantly greater in the SES as compared to the BMS group, while the percent diameter stenosis and in-stent lumen loss were significantly lower. Plasma monocyte chemotactic protein-1 (MCP-1) increased significantly after 14 days and 6 months and monocyte CCR2 expression increased 24 hr and 48 hr after stenting in the BMS but not the SES group. Changes in plasma MCP-1 (DeltaMCP-1) within 6 months after stenting correlated significantly with in-stent lumen loss. The DeltaMCP-1 (between 6 months and baseline) was significantly related only to the lumen loss (r=0.443, p=0.023), which suggests that the reduction of MCP-1 is the best contributor to decreased lumen loss.
  
  
  CONCLUSIONS
  These data suggest that reduction in MCP-1 production by SES may be one mechanism to prevent restenosis after coronary stenting.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka.
authors.forename: Hideto
authors.initials: H
authors.lastname: Sako
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Kawamura
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shirai
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D001324:Autoantigens / Q000096:biosynthesis* / Q000097:blood; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000517:prevention & control; D054855:Drug-Eluting Stents; D005260:Female; D015870:Gene Expression; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D054390:Receptors, CCR2 / Q000096:biosynthesis*; D020123:Sirolimus / Q000494:pharmacology*; D015607:Stents
chemical_list: D001324:Autoantigens; C515334:CCR2 protein, human; D007166:Immunosuppressive Agents; D054390:Receptors, CCR2; C487774:metaphase chromosome protein 1, human; D020123:Sirolimus