Incidence and risk factors of insulin resistance syndrome in 20-59 year-old Korean male workers.
We investigated the incidence of insulin resistance syndrome (IRS) according to the criteria of diagnoses suggested by the American College of Endocrinology/ American Association of Clinical Endocrinologists and the risk factors associated with the development of IRS. Among 2,048 subjects without a history of/or drug treatment for hypertension, diabetes, dyslipidemia with normal findings at baseline, 1,578 subjects aged 20-59 yr were followed prospectively for 2 yr. The incidence of IRS was 6.9 per 100 persons/year. The relative risk (RR) due to age was 1.03 (95% CI: 1.00-1.05) with every one-year increase in age. The RR associated with an abnormal waist-hip ratio group (> or =0.9) was increased by 1.74 (95% CI: 1.17-2.58) compared to the normal group (<0.9); RR associated with abnormal alanine transferase was increased (> or =35 IU/L) by 1.70 (95% CI: 1.20-2.41) compared to the normal group (<35 IU/L); and the RR associated with abnormal lowdensity lipoprotein (LDL) cholesterol was increased (> or =160 mg/L) by 1.70 (95% CI: 1.19-2.44) compared to the normal LDL cholesterol (<160 mg/L). Lastly, the RR of current smokers was increased by 1.63 (95% CI: 1.09-2.42) compared to that of non-smokers. It is necessary to develop methods of prevention and therapeutic approach to manage the integrated risk factors as opposed to individual factors.
Kim
Soo Geun
SG
Health Management Division, Radiation Health Research Institute, Korea Hydro and Nuclear Power. Co., LTD., Seoul, Korea. ksg6201@empal.com
Lim
Hyun Sul
HS
Cheong
Hae Kwan
HK
Kim
Chong Soon
CS
Seo
Hyun Ju
HJ
D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D049629:Waist-Hip Ratio
D008078:Cholesterol, LDL; D000410:Alanine Transaminase