title: Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii.
abstract: Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1-6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4'-O-methyl ether (1), 2',7-dihydroxy-4'-methoxy-5'-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2',7-dihydroxy-3'-(3-methylbut-2-enyl)-2''',2'''-dimethylpyrano[5''',6''' :4',5']isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity in vitro with IC(50) values ranging from 5.3 to 42.6 microM. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Korea.
authors.forename: JunPil
authors.initials: J
authors.lastname: Jang
authors.forename: Minkyun
authors.initials: M
authors.lastname: Na
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Njamen
authors.forename: Joseph Tanyi
authors.initials: JT
authors.lastname: Mbafor
authors.forename: Zacharias Tanee
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
mesh_terms: D002163:Cameroon; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*
chemical_list: D005419:Flavonoids; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1