Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency.
Cardioprotective effect of cardos was revealed on rat model of experimental cardiac insufficiency induced by injectionof isoproterenol. Cardos improved exercise tolerance, cardiac output, and stroke volume. Cardos administered for 28 days was no less effective than losartan.
Tiurenkov
I N
IN
Volgograd State Medical University, Federal Agency for Health Protection and Social Development.
Nazvanova
A N
AN
Tchepurina
N G
NG
Kheyfets
I A
IA
Dugina
J L
JL
Martyushev-Poklad
A V
AV
Sergeeva
S A
SA
Epstein
O I
OI
D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D006333:Heart Failure / Q000139:chemically induced / Q000188:drug therapy*; D007545:Isoproterenol / Q000633:toxicity; D019808:Losartan / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1 / Q000737:chemistry / Q000276:immunology
D047228:Angiotensin II Type 1 Receptor Blockers; D000906:Antibodies; D002316:Cardiotonic Agents; D010446:Peptide Fragments; D044140:Receptor, Angiotensin, Type 1; D019808:Losartan; D007545:Isoproterenol