title: Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian women.
abstract: OBJECTIVE
  To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance.
  
  
  METHODS
  Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared.
  
  
  RESULTS
  Mean +/- SD total (2,965 +/- 1,278 vs. 4,235 +/- 160 ng/ml) and HMW (1,001 +/- 352 vs. 1,591 +/- 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml) and HMW (987 +/- 479 vs. 1,935 +/- 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS.
  
  
  CONCLUSIONS
  Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.
authors.affiliation: Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Marlene
authors.initials: M
authors.lastname: Martin
authors.forename: Latha P
authors.initials: LP
authors.lastname: Palaniappan
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Kwan
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Reaven
authors.forename: Peter D
authors.initials: PD
authors.lastname: Reaven
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D044465:White People
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids