title: Pregnancy outcomes after laparoscopic Roux-en-Y gastric bypass.
abstract: BACKGROUND
  Early reports described adverse perinatal outcomes of pregnancies after weight loss surgery (WLS), which subsequently raised concerns regarding safety. Our objective was to investigate, in a community-based, academic, tertiary care center, the safety of pregnancies after laparoscopic Roux-en-Y gastric bypass (LRYGB) and its potential effect on obesity-related perinatal complications.
  
  
  METHODS
  The pregnancy outcomes of patients delivering infants after LRYGB at our institution were compared with those of control subjects (stratified by body mass index) who had not undergone WLS. The charts were retrospectively reviewed for demographics, delivery route, and perinatal complications.
  
  
  RESULTS
  A total of 26 patients who delivered after LRYGB and 254 controls were identified. The mean interval from LRYGB to conception was 25.4 +/- 13.0 months. In general, the perinatal complications in the LRYGB patients were similar to those in the nonobese controls and lower than in the obese and severe obese controls, although statistical significance was not noted for all complications. No spontaneous abortions or stillbirths occurred in the LRYGB patients. No LRYGB patients required intravenous nutrition or hydration. The overall incidence of cesarean section in the LRYGB patients was similar to that in the obese and severely obese controls but significantly greater than that in the nonobese controls. The complication rates were similar in pregnancies occurring "early" (<12 mo) versus "late" (>18 mo) after LRYGB.
  
  
  CONCLUSIONS
  The results of our study have shown that pregnancy after LRYGB is safe, with an incidence of perinatal complications similar to that of nonobese patients, and lower than that of obese and severely obese patients, who had not undergone WLS. Larger studies are required to demonstrate statistically significant improvements in outcome in patients treated with WLS.
authors.affiliation: Department of Surgery, Division of Bariatric Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
authors.forename: Jitesh A
authors.initials: JA
authors.lastname: Patel
authors.forename: Nilesh A
authors.initials: NA
authors.lastname: Patel
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Thomas
authors.forename: Justin K
authors.initials: JK
authors.lastname: Nelms
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Colella
mesh_terms: D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D015390:Gastric Bypass; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D010535:Laparoscopy; D009765:Obesity / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies