[Microcirculation in sepsis and septic shock - therapeutic options?].
In severe sepsis and septic shock the severe impairment of the microcirculation is one of the main reasons for tissue hypoxia, multiple organ failure and death. Fast resuscitation of the microvascular blood flow to improve the reduced functional capillary density is necessary. Based scientific evidence, an early haemodynamic stabilisation directed by predefined haemodynamic and metabolic goals and the application of activated protein C (rhAPC) according to the guidelines could be recommended. The specific effects of dobutamine and rhAPC on the microcirculation as well as the effects selective inhibitors of iNOS or vasodilators may be therapeutic options in the future.
Ragaller
Max
M
Klinik und Poliklinik für Anästhesiologie und Intensivtherapieam Universitätsklinikum Dresden. Maximilian.Ragaller@uniklinikum-dresden.de
D001205:Ascorbic Acid / Q000627:therapeutic use*; D004280:Dobutamine / Q000627:therapeutic use*; D005858:Germany; D006801:Humans; D008833:Microcirculation / Q000473:pathology*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D018805:Sepsis / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy; D014657:Vasculitis / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D004280:Dobutamine; D001205:Ascorbic Acid