title: Polyfunctionalized pyrrolidines by Ugi multicomponent reaction followed by palladium-mediated SN2' cyclizations.
abstract: A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R5 = H) or a Pd(0)-mediated (R5 = CO2Me) SN2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.
authors.affiliation: Università di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, 16146-Genova, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Banfi
authors.forename: Andrea
authors.initials: A
authors.lastname: Basso
authors.forename: Valentina
authors.initials: V
authors.lastname: Cerulli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guanti
authors.forename: Renata
authors.initials: R
authors.lastname: Riva
mesh_terms: D003500:Cyclization; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011759:Pyrrolidines; D010165:Palladium