Sirt1 protects the heart from aging and stress.
The prevalence of heart diseases, such as coronary artery disease and congestive heart failure, increases with age. Optimal therapeutic interventions that antagonize aging may reduce the occurrence and mortality of adult heart diseases. We discuss here how molecular mechanisms mediating life span extension affect aging of the heart and its resistance to pathological insults. In particular, we review our recent findings obtained from transgenic mice with cardiac-specific overexpression of Sirt1, which demonstrated delayed aging and protection against oxidative stress in the heart. We propose that activation of known longevity mechanisms in the heart may represent a novel cardioprotection strategy against aging and certain types of cardiac stress, such as oxidative stress.
Hsu
Chiao-Po
CP
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Odewale
Ibrahim
I
Alcendor
Ralph R
RR
Sadoshima
Junichi
J
D000375:Aging / Q000187:drug effects*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D031204:Caloric Restriction; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006331:Heart Diseases / Q000517:prevention & control*; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D008136:Longevity / Q000502:physiology; D051379:Mice; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D000077185:Resveratrol; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D056564:Sirtuin 1; D037761:Sirtuins / Q000502:physiology*; D013267:Stilbenes / Q000494:pharmacology; D015854:Up-Regulation
D013267:Stilbenes; D054409:Nicotinamide Phosphoribosyltransferase; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins; D000077185:Resveratrol