title: Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.
abstract: BACKGROUND
  Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia.
  
  
  METHODS
  Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study.
  
  
  RESULTS
  Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms.
  
  
  CONCLUSIONS
  YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo, 693-8501, Japan. miyanyan@med.shimane-u.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyaoka
authors.forename: Motohide
authors.initials: M
authors.lastname: Furuya
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yasuda
authors.forename: Maiko
authors.initials: M
authors.lastname: Hayashida
authors.forename: Akira
authors.initials: A
authors.lastname: Nishida
authors.forename: Takuji
authors.initials: T
authors.lastname: Inagaki
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D004365:Drugs, Chinese Herbal; C524644:Yi-Gan San