HDAC6 a new cellular stress surveillance factor.
Less than a decade has passed since HDAC6 was first identified and regarded as an unusual histone deacetylase harbouring two catalytic domains. Early demonstration of its cytoplasmic localisation, its ubiquitin-binding and its tubulin-deacetylase activities took HDAC6 far away from everything known to involve other histone-deacetylases. Recent discoveries confirmed the very unique functions of HDAC6 among deacetylases and pointed to this protein as a master regulator of cell response to cytotoxic assaults. HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses.
Matthias
Patrick
P
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland.
Yoshida
Minoru
M
Khochbin
Saadi
S
D000107:Acetylation; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D001343:Autophagy / Q000235:genetics / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D003599:Cytoskeleton / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*
C499033:Hdac6 protein, mouse; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases