Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth.
OBJECTIVE
The objective of this study was to investigate the association among adiposity, insulin resistance, and inflammatory markers [high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha] and adiponectin and to study the effects of exercise training on adiposity, insulin resistance, and inflammatory markers among obese male Korean adolescents.


METHODS
Twenty-six obese and 14 lean age-matched male adolescents were studied. We divided the obese subjects into two groups: obese exercise group (N = 14) and obese control group (N = 12). The obese exercise group underwent 6 weeks of jump rope exercise training (40 min/d, 5 d/wk). Adiposity, insulin resistance, lipid profile, hs-CRP, IL-6, TNF-alpha, and adiponectin were measured before and after the completion of exercise training.


RESULTS
The current study demonstrated higher insulin resistance, total cholesterol, LDL-C levels, triglyceride, and inflammatory markers and lower adiponectin and HDL-C in obese Korean male adolescents. Six weeks of increased physical activity improved body composition, insulin sensitivity, and adiponectin levels in obese Korean male adolescents without changes in TNF-alpha, IL-6, and hs-CRP.


CONCLUSIONS
Obese Korean male adolescents showed reduced adiponectin levels and increased inflammatory cytokines. Six weeks of jump rope exercise improved triglyceride and insulin sensitivity and increased adiponectin levels.
Kim
Eun Sung
ES
Department of Sport and Leisure Studies, Yonsei University, Seodaemun-Gu Shinchon-Dong 134, Seoul, Korea.
Im
Jee-Aee
JA
Kim
Kyoung Chul
KC
Park
Ji Hye
JH
Suh
Sang-Hoon
SH
Kang
Eun Seok
ES
Kim
So Hun
SH
Jekal
Yoonsuk
Y
Lee
Chul Won
CW
Yoon
Yong-Jin
YJ
Lee
Hyun Chul
HC
Jeon
Justin Y
JY
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D015850:Interleukin-6 / Q000097:blood; D007723:Korea; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015850:Interleukin-6; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein