Mammalian cells change volume during mitosis.
Using single cell-imaging methods we have found that the volume of adherent cells grown in culture decreases as the cells rounds when it enters mitosis. A minimal volume is reached at metaphase. Rapid volume recovery initiates before abscission as cells make the transition from metaphase to cytokinesis. These volume changes are simultaneous with the rapid surface area decrease and recovery observed in mitotic cells [1].
Boucrot
Emmanuel
E
Department of Cell Biology and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, USA.
Kirchhausen
Tomas
T
D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D048429:Cell Size; D005453:Fluorescence; D000882:Haplorhini; D008938:Mitosis