title: Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes.
abstract: We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin's lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin's lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.
authors.affiliation: Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk.
authors.forename: N V
authors.initials: NV
authors.lastname: Ryazantseva
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskii
authors.forename: L S
authors.initials: LS
authors.lastname: Litvinova
authors.forename: S B
authors.initials: SB
authors.lastname: Tkachenko
authors.forename: Yu V
authors.initials: YV
authors.lastname: Kolobovnikova
authors.forename: O B
authors.initials: OB
authors.lastname: Zhukova
authors.forename: E S
authors.initials: ES
authors.lastname: Grigor'eva
authors.forename: E V
authors.initials: EV
authors.lastname: Suvorova
authors.forename: E N
authors.initials: EN
authors.lastname: Knutareva
authors.forename: T T
authors.initials: TT
authors.lastname: Radzivil
authors.forename: N Yu
authors.initials: NY
authors.lastname: Chasovskikh
mesh_terms: D000293:Adolescent; D000328:Adult; D017209:Apoptosis / Q000187:drug effects*; D016022:Case-Control Studies; D002478:Cells, Cultured; D019742:Chemokines, CC / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D004802:Eosinophilia / Q000097:blood; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D015848:Interleukin-5 / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D019742:Chemokines, CC; D007377:Interleukin-3; D015848:Interleukin-5; D011994:Recombinant Proteins