Brain response to visual sexual stimuli in homosexual pedophiles.
OBJECTIVE
The neurobiological mechanisms of deviant sexual preferences such as pedophilia are largely unknown. The objective of this study was to analyze whether brain activation patterns of homosexual pedophiles differed from those of a nonpedophile homosexual control group during visual sexual stimulation.


METHODS
A consecutive sample of 11 pedophile forensic inpatients exclusively attracted to boys and 12 age-matched homosexual control participants from a comparable socioeconomic stratum underwent functional magnetic resonance imaging during a visual sexual stimulation procedure that used sexually stimulating and emotionally neutral photographs. Sexual arousal was assessed according to a subjective rating scale.


RESULTS
In contrast to sexually neutral pictures, in both groups sexually arousing pictures having both homosexual and pedophile content activated brain areas known to be involved in processing visual stimuli containing emotional content, including the occipitotemporal and prefrontal cortices. However, during presentation of the respective sexual stimuli, the thalamus, globus pallidus and striatum, which correspond to the key areas of the brain involved in sexual arousal and behaviour, showed significant activation in pedophiles, but not in control subjects.


CONCLUSIONS
Central processing of visual sexual stimuli in homosexual pedophiles seems to be comparable to that in nonpedophile control subjects. However, compared with homosexual control subjects, activation patterns in pedophiles refer more strongly to subcortical regions, which have previously been discussed in the context of processing reward signals and also play an important role in addictive and stimulus-controlled behaviour. Thus future studies should further elucidate the specificity of these brain regions for the processing of sexual stimuli in pedophilia and should address the generally weaker activation pattern in homosexual men.
Schiffer
Boris
B
Department of Forensic Psychiatry, University of Duisburg-Essen, Essen, Germany. boris.schiffer@uni-essen.de
Krueger
Tillmann
T
Paul
Thomas
T
de Greiff
Armin
A
Forsting
Michael
M
Leygraf
Norbert
N
Schedlowski
Manfred
M
Gizewski
Elke
E
D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D003710:Demography; D004882:Erotica; D006716:Homosexuality / Q000523:psychology* / Q000706:statistics & numerical data*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010378:Pedophilia / Q000453:epidemiology* / Q000523:psychology*; D010775:Photic Stimulation