title: [A case report of inoperable gastric cancer demonstrating a clinical CR after chemo-radiation therapy employing weekly DOC].
abstract: A 76-year-old man was admitted to our hospital complaining a weight loss and dysphagia. Gastro-intestinal fiberscopy (GIF) examination showed an early gastric cancer located at cardia. Because of his severe co-morbidities, such as unruptured intracranial aneurysm and idiopathic ventricular fibrillation, he was considered to be inoperable and only followed periodically by the GIF examination every half year. After 3 years since his first examination, the gastric cancer progressed to be T2 advanced gastric cancer. Chemo-radiation therapy (CRT) was administered for consecutive 5 weeks in the following fashion: weekly docetaxel (DOC) div 20 mg/m2 x 5 weeks, and RT 1.8 Gy/day x 5 days/week x 5 weeks. Although the CRT was completed on schedule, diarrhea of grade 3, serum creatinine elevation of grade 2, and esophageal candidiasis appeared during the therapy. A month later after the completion of CRT, the tumor disappeared thoroughly, leaving the tiny redness on the mucosa of cardia. Two months later after CRT, GIF examination reconfirmed the disappearance of the tumor. The patient has shown a clinical complete response (CR), suggesting the efficacy of CRT for inoperable gastric cancer.
authors.affiliation: Dept. of Surgery, National Hospital Organization, Osaka National Hospital.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohmura
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Hideya
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yasui
authors.forename: Norikazu
authors.initials: N
authors.lastname: Masuda
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashiwazaki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Michihiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Koji
authors.initials: K
authors.lastname: Takami
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
mesh_terms: D000368:Aged; D000077143:Docetaxel; D005773:Gastroscopy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D043823:Taxoids / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011838:Radiation-Sensitizing Agents; D043823:Taxoids; D000077143:Docetaxel