Possible genotoxic modes of action for naphthalene.
This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS(3)), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.
Brusick
David
D
Department of Environmental Engineering, Carnegie Mellon University, USA. brusick41@aol.com
Small
Mitchell S
MS
Cavalieri
Ercole L
EL
Chakravarti
Dhrubajyoti
D
Ding
Xinxin
X
Longfellow
David G
DG
Nakamura
Jun
J
Rogan
Eleanor C
EC
Swenberg
James A
JA
D000393:Air Pollutants / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D002274:Carcinogens, Environmental / Q000378:metabolism / Q000633:toxicity*; D032921:Consensus; D004247:DNA / Q000187:drug effects; D018736:DNA Adducts; D004249:DNA Damage; D006801:Humans; D019570:Inhalation Exposure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D009281:Naphthalenes / Q000378:metabolism / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics* / Q000378:metabolism; D018570:Risk Assessment
D000393:Air Pollutants; D002274:Carcinogens, Environmental; D018736:DNA Adducts; D009153:Mutagens; D009281:Naphthalenes; D004247:DNA