Insulin-like growth factor axis and oncogenic human papillomavirus natural history.
High serum levels of insulin-like growth factor-I (IGF-I) are reported to be a risk factor for several common cancers, and recent cross-sectional data suggest a possible additional association of IGF-I with cervical neoplasia. To prospectively assess whether circulating IGF-I levels influence the natural history of oncogenic human papillomavirus (HPV), the viral cause of cervical cancer, we conducted a pilot investigation of 137 women who underwent semiannual type-specific HPV DNA PCR testing and cervical cytology. Total IGF-I and IGF binding protein-3 (IGFBP-3), the most abundant IGFBP in circulation, were measured using baseline serum specimens. Having a high IGF-I/IGFBP-3 ratio was associated with increased persistence of oncogenic HPV infection [that is, a lower rate of clearance; adjusted hazard ratio (AHR), 0.14; 95% confidence interval (95% CI), 0.04-0.57], whereas IGFBP-3 was inversely associated with both the incident detection of oncogenic HPV (AHR, 0.35; 95% CI, 0.13-0.93) and the incidence of oncogenic HPV-positive cervical neoplasia (that is, squamous intraepithelial lesions at risk of progression; AHR, 0.07; 95% CI, 0.01-0.66). These prospective data provide initial evidence that the IGF axis may influence the natural history of oncogenic HPV.
Harris
Tiffany G
TG
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Burk
Robert D
RD
Yu
Herbert
H
Minkoff
Howard
H
Massad
L Stewart
LS
Watts
D Heather
DH
Zhong
Ye
Y
Gange
Stephen
S
Kaplan
Robert C
RC
Anastos
Kathryn
K
Levine
Alexandra M
AM
Moxley
Michael
M
Xue
Xiaonan
X
Fazzari
Melissa
M
Palefsky
Joel M
JM
Strickler
Howard D
HD
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000378:metabolism / Q000821:virology; D010865:Pilot Projects; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000821:virology
D004279:DNA, Viral; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I