[A case of advanced gastric cancer with obstructive jaundice due to liver metastases successfully treated with chemotherapy].
We report a successful case of chemotherapy for primary far-advanced gastric cancer accompanied with poor general condition related to jaundice due to hepatic metastasis. A 54-year-old man, who had been admitted to another hospital in October 2006 with a complaint of tarry stool, was referred to our hospital. The result of detailed examination revealed an advanced gastric cancer, multiple lymph node metastases and jaundice (T-Bil 3.3 mg/dL) due to multiple hepatic metastases. The performance status (PS) was level 4. In parallel with a whole body control, a combined therapy with S-1 and CPT-11 was performed from October 27 as the first-line therapy. As a consequence of the first course, the jaundice disappeared. After the second course, the patient left the hospital. However, the patient was re-admitted to hospital in January 2007 by a reason of fever and a deterioration of PS. As exacerbation of cancerous peritonitis and the primary tumor were seen, a weekly paclitaxel therapy was performed as the second-line therapy. Two courses of treatment resulted in the disappearance of ascites and a reduction of hepatic/lymph node metastasis. PS was improved to level 0 as well. After these therapies, the patient was discharged from the hospital. As of June 2007, he continuously receives chemotherapy as an outpatient.
Miyazaki
Yasuhiro
Y
Dept. of Surgery, Sakai Municipal Hospital.
Imamura
Hiroshi
H
Furukawa
Hiroshi
H
Kishimoto
Tomono
T
Ohta
Katsuya
K
Nakata
Yasuyuki
Y
Ohshiro
Ryouta
R
Kamigaki
Shunji
S
Takemoto
Hiroyoshi
H
Fujimi
Satoshi
S
Nakayama
Takahiro
T
Fukunaga
Mutsumi
M
Ohsata
Hiroki
H
Tatsuta
Masayuki
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005773:Gastroscopy; D006801:Humans; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014057:Tomography, X-Ray Computed