Stem cells as in vitro models of disease.
Although the use of stem cells in cell-replacement therapies by transplantation is obvious, another equally important and interesting application of stem cells is to use them in disease modeling. Disease models serve as a platform to dissect the biochemical mechanisms of normal phenotypes and the processes which go awry during disease conditions. Particularly in complex, multigenic diseases, molecular studies lead to a greater understanding of the disease, and perhaps more targeted approaches for therapies. Stem cells provide an ideal in vitro system in which to study events related to development at the molecular and cellular level. Neural stem cells have been used as excellent models to study the mechanisms of differentiation of cells of the central nervous system. These studies may be particularly relevant to diseases of complex etiology such as psychiatric illnesses, neurodegenerative diseases and brain tumors. Stem cell-derived systems are also being developed to create models of cardiovascular disease. The application of stem cells to the study of cardiovascular illnesses, and vertebrate heart development, is discussed.
Ruiz-Lozano
Pilar
P
Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Rajan
Prithi
P
D000818:Animals; D001321:Autistic Disorder / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D001932:Brain Neoplasms / Q000209:etiology / Q000235:genetics / Q000628:therapy; D002318:Cardiovascular Diseases / Q000209:etiology / Q000628:therapy; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D049109:Cell Proliferation; D002490:Central Nervous System / Q000254:growth & development* / Q000503:physiopathology; D004815:Epidermal Growth Factor / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D006321:Heart / Q000196:embryology / Q000254:growth & development / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000628:therapy; D051381:Rats; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D051153:Wnt Proteins / Q000378:metabolism
D050791:STAT Transcription Factors; D051153:Wnt Proteins; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor