title: Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan.
abstract: The prognostic implication of SYT-SSX fusion type in synovial sarcomas is still controversial. The aim of this study is to clarify the prognostic impact of fusion type, in association with other clinical factors, in patients with synovial sarcoma in Japan. Data on 108 SYT-SSX fusion transcript-positive patients with synovial sarcoma, treated in 11 tertiary referral cancer centers in Japan, were retrospectively analyzed. The following parameters were examined for their potential prognostic impact: SYT-SSX fusion type, patient age at presentation, sex, primary tumor location, tumor size, histological subtype, histological grade, treatment modalities and disease stage at presentation. Among the patients with localized disease at presentation, 5-year overall survival (OS) for SYT-SSX1 and -2 subgroups were 84.4 and 74.9%, respectively (P=0.244). Five-year metastasis-free survival (MFS) rates were 67.8% for SYT-SSX1 and 68.5% for SYT-SSX2 (P=0.949). Univariate survival analyses for 91 patients with localized disease at presentation showed that tumor size was the only significant prognostic factor for OS (P=0.0033) and MFS (P=0.0029) and the histological grade was marginally significant for MFS (P=0.0785), whereas the SYT-SSX fusion type and other variables were not. Multivariate survival analyses further indicated that tumor size was the most significant independent prognostic factor for OS and MFS and the histological grade was also significant for MFS. In conclusion, the SYT-SSX fusion type is not a significant prognostic factor unlike tumor size, followed by histological grade for patients with localized synovial sarcoma in Japan.
authors.affiliation: Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Japan. uedat@onh.go.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takenaka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueda
authors.forename: Norifumi
authors.initials: N
authors.lastname: Naka
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Araki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Myoui
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Tomitaka
authors.initials: T
authors.lastname: Nakayama
authors.forename: Junya
authors.initials: J
authors.lastname: Toguchida
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsumine
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
authors.forename: Makoto
authors.initials: M
authors.lastname: Ieguchi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kaya
authors.forename: Takuro
authors.initials: T
authors.lastname: Wada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Baba
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kudawara
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Aoki
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis*; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C116512:SYT-SSX fusion protein