title: The expression of anamorsin in diffuse large B cell lymphoma: possible prognostic biomarker for low IPI patients.
abstract: Anamorsin is a cell-death-defying factor, which was originally isolated as a molecule that conferred resistance to apoptosis induced by growth factor starvation. In order to evaluate anamorsin expression levels in malignant lymphoma, we immunostained paraffin-embedded sections with anti-anamorsin monoclonal antibodies. About 40% (89/234) of sections from patients with diffuse large B cell lymphoma (DLBCL) showed strong anamorsin expression. Comparing the level of anamorsin expression in DLBCL patients with their clinical features (i.e., overall survival rate, International Prognostic Index (IPI) parameters, and treatment response) revealed no significant correlation between anamorsin expression levels and these clinical features. However, anamorsin expression in DLBCL patients with a low IPI was shown to be an unfavorable biomarker, especially in the patients who received chemotherapy without rituximab. It is suggested that anamorsin might play some roles in the abnormal growth of DLBCL.
authors.affiliation: Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Takae
authors.initials: T
authors.lastname: Shizusawa
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Shibayama
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Murata
authors.forename: Yuri
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Yuna
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Itaru
authors.initials: I
authors.lastname: Matsumura
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
authors.forename: Haruo
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Shirou
authors.initials: S
authors.lastname: Fukuhara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
authors.forename: Akihisa
authors.initials: A
authors.lastname: Kanamaru
authors.forename: Amane
authors.initials: A
authors.lastname: Yamauchi
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; C489114:CIAPIN1 protein, human; D047908:Intracellular Signaling Peptides and Proteins