Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata.
A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.
Buchanan
Malcolm S
MS
Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia.
Carroll
Anthony R
AR
Edser
Annette
A
Sykes
Melissa
M
Fechner
Gregory A
GA
Forster
Paul I
PI
Guymer
Gordon P
GP
Quinn
Ronald J
RJ
D001120:Arginine / Q000031:analogs & derivatives*; D043424:Carboxypeptidase B / Q000037:antagonists & inhibitors*; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028183:Loranthaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013386:Succinates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D006146:Guanidines; D010936:Plant Extracts; D011480:Protease Inhibitors; D013386:Succinates; C528726:lysianadioic acid; D001120:Arginine; D043424:Carboxypeptidase B