Palladium-catalyzed one-pot synthesis of 2-alkyl-2-arylcyanoacetates.
A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)2/DPPF (DPPF = 1,1'-diphenylphosphino ferreocene)-catalyzed enolate arylation followed by in situ alkylation has been developed. This procedure tolerates a diverse range of aryl and heteroaryl bromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.
Wang
Xiang
X
Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. xiangw@amgen.com
Guram
Anil
A
Bunel
Emilio
E
Cao
Guo-Qiang
GQ
Allen
Jennifer R
JR
Faul
Margaret M
MM
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*
D000085:Acetates; D010165:Palladium