Stem cell therapy: MRI guidance and monitoring.
With the recent advances in magnetic resonance (MR) labeling of cellular therapeutics, it is natural that interventional MRI techniques for targeting would be developed. This review provides an overview of the current methods of stem cell labeling and the challenges that are created with respect to interventional MRI administration. In particular, stem cell therapies will require specialized, MR-compatible devices as well as integration of graphical user interfaces with pulse sequences designed for interactive, real-time delivery in many organs. Specific applications that are being developed will be reviewed as well as strategies for future translation to the clinical realm.
Kraitchman
Dara L
DL
Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21287, USA. dkraitc1@jhu.edu
Gilson
Wesley D
WD
Lorenz
Christine H
CH
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D033581:Stem Cell Transplantation / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D014584:User-Computer Interface
D003287:Contrast Media