title: Inflammatory manifestations in chronic granulomatous disease (CGD).
abstract: Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections with bacteria and fungi as well as dysregulated inflammatory mechanisms. CGD is caused by defects in the NADPH oxidase, the enzyme complex responsible for generation of superoxide and other reactive oxygen species (ROS) in phagocytic cells. In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence.
authors.affiliation: Servicio de Inmunología, Hospital Nacional de Pediatría J. P. Garrahan, Combate de los Pozos 1881, (1245) Buenos Aires, Argentina. srosenzweig@garrahan.gov.ar
authors.forename: S D
authors.initials: SD
authors.lastname: Rosenzweig
mesh_terms: D015551:Autoimmunity / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D050172:Genes, X-Linked; D006105:Granulomatous Disease, Chronic / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D008297:Male; D009154:Mutation; D019255:NADPH Oxidases / Q000235:genetics* / Q000276:immunology; D010586:Phagocytes / Q000276:immunology
chemical_list: D019255:NADPH Oxidases