Recent advances in flavivirus antiviral drug discovery and vaccine development.
Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.
Ray
Debashish
D
Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Shi
Pei-Yong
PY
D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015478:Antigens, Heterophile / Q000276:immunology; D000998:Antiviral Agents / Q000494:pharmacology*; D004265:DNA Helicases / Q000037:antagonists & inhibitors; D015195:Drug Design; D005416:Flavivirus / Q000187:drug effects* / Q000235:genetics; D018177:Flavivirus Infections / Q000188:drug therapy* / Q000517:prevention & control*; D016679:Genome, Viral; D006801:Humans; D007116:Immunization, Passive; D050506:Mutant Chimeric Proteins / Q000276:immunology; D010330:Patents as Topic; D011480:Protease Inhibitors / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000627:therapeutic use; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA / Q000627:therapeutic use; D022223:Vaccines, Subunit / Q000627:therapeutic use; D014765:Viral Vaccines / Q000737:chemistry / Q000627:therapeutic use*; D019065:Virus Assembly / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D015478:Antigens, Heterophile; D000998:Antiviral Agents; D050506:Mutant Chimeric Proteins; D011480:Protease Inhibitors; D034741:RNA, Small Interfering; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014765:Viral Vaccines; D000255:Adenosine Triphosphate; D004265:DNA Helicases