Spurring radical reactions of organic halides with tin hydride and TTMSS using microreactors.
Tributyltin hydride-mediated radical reactions of organic halides were successfully carried out in a continuous flow system using a microreactor. The reactions proceeded within a very short period of time, coupled with quickly decomposing radical initiators such as V-65 and V-70. The continuous flow reaction system was applied to gram scale synthesis of a key intermediate for furofuran lignans.
Fukuyama
Takahide
T
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Kobayashi
Masahide
M
Rahman
Md Taifur
MT
Kamata
Naoya
N
Ryu
Ilhyong
I