[Trimetazidine-induced encephalopathy with choreiform disorders: a case report].
Trimetazidine is known to induce parkinsonism but choreiform disorders have not yet been described with this drug. A 88-year-old patient treated with trimetazidine developed choreiform movements, gait disorders, tremor and visual hallucinations. These symptoms disappeared after drug withdrawal. Although this drug contains a piperazinic ring like other anti-dopaminergic drugs which are already known to potentially induce chorea like neuroleptics and some anti-convulsive drugs. When a patient treated with trimetazidine develops or worsens motor disorders (parkinsonism or choreiform disorders), this drug must be stopped.
Sivet
J
J
Centre régional de pharmacovigilance de Caen Basse-Normandie, CHRU Côte de Nacre, 14033 Caen cedex, France.
de la Gastine
B
B
Mosquet
B
B
Lescure
P
P
Boutemy
J
J
Le Boisselier
R
R
Coquerel
A
A
D000369:Aged, 80 and over; D001928:Brain Diseases, Metabolic / Q000139:chemically induced*; D002819:Chorea / Q000139:chemically induced*; D005128:Eye Diseases / Q000188:drug therapy; D006801:Humans; D008297:Male; D014292:Trimetazidine / Q000008:administration & dosage / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
D014665:Vasodilator Agents; D014292:Trimetazidine