title: Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study.
abstract: BACKGROUND
  The study aimed to compare the cost-effectiveness of concomitant and adjuvant temozolomide (TMZ) for the treatment of newly diagnosed glioblastoma multiforme versus initial radiotherapy alone from a public health care perspective.
  
  
  METHODS
  The economic evaluation was performed alongside a randomized, multicenter, phase 3 trial. The primary endpoint of the trial was overall survival. Costs included all direct medical costs. Economic data were collected prospectively for a subgroup of 219 patients (38%). Unit costs for drugs, procedures, laboratory and imaging, radiotherapy, and hospital costs per day were collected from the official national reimbursement lists based on 2004. For the cost-effectiveness analysis, survival was expressed as 2.5 years restricted mean estimates. The incremental cost-effectiveness ratio (ICER) was constructed. Confidence intervals for the ICER were calculated using the Fieller method and bootstrapping.
  
  
  RESULTS
  The difference in 2.5 years restricted mean survival between the treatment arms was 0.25 life-years and the ICER was euro37,361 per life-year gained with a 95% confidence interval (CI) ranging from euro19,544 to euro123,616. The area between the survival curves of the treatment arms suggests an increase of the overall survival gain for a longer follow-up. An extrapolation of the overall survival per treatment arm and imputation of costs for the extrapolated survival showed a substantial reduction in ICER.
  
  
  CONCLUSIONS
  The ICER of euro37,361 per life-year gained is a conservative estimate. We concluded that despite the high TMZ acquisition costs, the costs per life-year gained are comparable to accepted first-line treatment with chemotherapy in patients with cancer.
authors.affiliation: Institute for Medical Technology Assessment bv, Erasmus University Medical Center, Rotterdam, Netherlands.
authors.forename: Leida M
authors.initials: LM
authors.lastname: Lamers
authors.forename: Roger
authors.initials: R
authors.lastname: Stupp
authors.forename: Martin J
authors.initials: MJ
authors.lastname: van den Bent
authors.forename: Maiwenn J
authors.initials: MJ
authors.lastname: Al
authors.forename: Thierry
authors.initials: T
authors.lastname: Gorlia
authors.forename: Jean-Blaise
authors.initials: JB
authors.lastname: Wasserfallen
authors.forename: Nicole
authors.initials: N
authors.lastname: Mittmann
authors.forename: Soo
authors.initials: S
authors.lastname: Jin Seung
authors.forename: Ralph
authors.initials: R
authors.lastname: Crott
authors.forename: Carin A
authors.initials: CA
authors.lastname: Uyl-de Groot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000191:economics* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000191:economics* / Q000532:radiotherapy; D003362:Cost-Benefit Analysis; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy / Q000191:economics* / Q000532:radiotherapy; D017048:Health Care Costs; D006801:Humans; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D015996:Survival Rate; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide