Understanding lupus: fishing genes out of mice and men.
In this issue of Immunity, the Coronin-1A gene Coro1a, which regulates cytoskeletal structure, is shown by Haraldsson et al. (2007) to be a surprising disease-susceptibility gene that contributes to the spontaneous systemic autoimmunity in the MRL mouse, a model of systemic lupus erythematosus.
Vyse
Tim J
TJ
Division of Medicine, Imperial College London, London SW7 2AZ, UK. t.vyse@imperial.ac.uk <t.vyse@imperial.ac.uk>
D000818:Animals; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D051379:Mice