Combination echinocandin-polyene treatment of murine mucormycosis.
We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
Ibrahim
Ashraf S
AS
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. ibrahim@labiomed.org
Gebremariam
Teclegiorgis
T
Fu
Yue
Y
Edwards
John E
JE
Spellberg
Brad
B
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage / Q000627:therapeutic use; D008081:Liposomes / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D051379:Mice; D008807:Mice, Inbred BALB C; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology; D011090:Polyenes / Q000008:administration & dosage / Q000627:therapeutic use; D012233:Rhizopus / Q000145:classification / Q000187:drug effects*; D016896:Treatment Outcome
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D008081:Liposomes; D011090:Polyenes; D000666:Amphotericin B; D000077612:Anidulafungin; D000077551:Micafungin