title: Aspirin-associated intracerebral hemorrhage in a patient with CADASIL.
abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease characterized by ischemic stroke, cognitive impairment, migraine and neuropsychological deficit. Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown. We present a 39-year-old man with CADASIL who had two years history of untreated hypertension. In this patient, acute ICH developed only two weeks after the initiation of aspirin. Brain images demonstrated a 3cmx3cm hyperacute ICH in the left temporal lobe at the site of previous old hemorrhage. The presence of cerebral microbleed and use of antithrombotics may be associated with development of ICH in patients with CADASIL.
authors.affiliation: Department of Neurology, Cheju National University School of Medicine, Jeju, Republic of Korea.
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Oh
authors.forename: Jung Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Sa-Yoon
authors.initials: SY
authors.lastname: Kang
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kang
authors.forename: Jay Chol
authors.initials: JC
authors.lastname: Choi
mesh_terms: D000208:Acute Disease; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D046589:CADASIL / Q000150:complications* / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D038524:Diffusion Magnetic Resonance Imaging; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control; D013702:Temporal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin