Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry.
This study reports on the uptake of (99m)Tc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC).


METHODS
Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant bone-mestastasized breast carcinoma underwent (99m)Tc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive.


RESULTS
The uptake of (99m)Tc-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. (99m)Tc-RP527 uptake was not found in any of the tamoxifen-resistant patients.


CONCLUSIONS
Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.
Van de Wiele
Christophe
C
Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. christophe.vandewiele@ugent.be
Phonteyne
Philippe
P
Pauwels
Patrick
P
Goethals
Ingeborg
I
Van den Broecke
Rudi
R
Cocquyt
Veronique
V
Dierckx
Rudi Andre
RA
D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009842:Oligopeptides / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018004:Receptors, Bombesin / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
D009842:Oligopeptides; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; C420883:technetium Tc 99m RP527