title: Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes.
abstract: Dendritic cells (DCs) control T cell-based immunity. To do so they need to mature and migrate to sites of T-cell priming. We have previously shown that cognate interactions of human CD4+ T cells with DCs induce DC maturation. We show here that CC chemokines produced during antigen-specific T-DC interactions also induce strong morphologic modifications and migration of immature DCs. These modifications are required for efficient T-cell activation. Moreover, we show that CC chemokines produced during antigen-specific DC-T-cell interactions induce the dissolution of structures involved in cell motility and present on immature DCs (ie, podosomes). We thus propose a model in which chemokines secreted during Ag-specific contact between T cells and DCs induce disassembly of interacting and neighboring immature DC podosomes, leading to recruitment of more immature DCs toward sites of antigenic stimulation and to amplification of T-cell responses.
authors.affiliation: Institut Curie, Centre de Recherce, Paris, France.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Nobile
authors.forename: Marianne
authors.initials: M
authors.lastname: Lind
authors.forename: Francesc
authors.initials: F
authors.lastname: Miro
authors.forename: Karine
authors.initials: K
authors.lastname: Chemin
authors.forename: Marie
authors.initials: M
authors.lastname: Tourret
authors.forename: Giovanni
authors.initials: G
authors.lastname: Occhipinti
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dogniaux
authors.forename: Sebastian
authors.initials: S
authors.lastname: Amigorena
authors.forename: Claire
authors.initials: C
authors.lastname: Hivroz
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D018925:Chemokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological
chemical_list: D018925:Chemokines