Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci.
The aim of this population genetics study was to compare the genetic structure of Mexican women with breast cancer (BrCa) with previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico). A sample of 115 unrelated women with BrCa and whose four grandparents were born in five zones of Mexico were interviewed at a reference hospital in Northeastern Mexico. Noncodifying STRs D7S820, D13S317, and D16S39 were analyzed; genotype distribution was in agreement with Hardy-Weinberg expectations for all three markers. Similar allele frequencies among four random populations and this selected population were found. According with this and previous studies using molecular and nonmolecular nuclear DNA markers not associated with any disease, Mexican Mestizo population is genetically homogeneous and therefore, genetic causes of BrCa are less heterogeneous, simplifying genetic epidemiologic studies.
Calderón-Garcidueñas
Ana L
AL
Departamento de Genética de Poblaciones y Bioinformática, Centro de Investigación Biomédica del Noreste (CIBIN), Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León, Mexico.
Rivera-Prieto
Roxana A
RA
Ortíz-Lopez
Rocio
R
Rivas
Fernando
F
Barrera-Saldaña
Hugo A
HA
Peñaloza-Espinosa
Rosenda I
RI
Cerda-Flores
Ricardo M
RM
D000328:Adult; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020080:Tandem Repeat Sequences; D044465:White People / Q000235:genetics*