Genotyping OLR1 gene: a genomic biomarker for cardiovascular diseases.
The human lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that has been implicated in the pathogenesis of atherosclerosis. LOX-1 activation is an important mechanism that contributes to plaque instability and subsequent development of acute coronary syndromes. Association studies have implicated OLR1 gene variants in myocardial infarction (MI) susceptibility. In particular, previously we demonstrated that intronic SNPs associated to susceptibility to myocardial infarction, regulate the expression of a new functional splicing isoform of the OLR1 gene, called LOXIN. The ratio OLR1/LOXIN mRNA is increased in subjects carrying the risk haplotype. On this basis, we developed a genetic kit named "LOXIN test" that allows the rapid identification of ORL1 genotypes and therefore establish the susceptibility risk to atherosclerosis and myocardial infarction. The recent patents related to OLR1, SNPs and LOXIN are also discussed in this article.
Vecchione
Lucia
L
Department of Biopathology and Diagnostic Imaging, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Tor Vergata, Rome, Italy.
Gargiul
Elisa
E
Borgiani
Paola
P
Predazzi
Irene
I
Mango
Ruggiero
R
Romeo
Francesco
F
Magnani
Mauro
M
Novelli
Giuseppe
G
D002318:Cardiovascular Diseases / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D051127:Scavenger Receptors, Class E / Q000235:genetics* / Q000502:physiology
D005819:Genetic Markers; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E