Blowing off acid: a new tool to study Na+/HCO3- co-transport.
Investigation of the physiological functions and possible pathological roles of Na(+)/HCO(3)(-) co-transport in the heart has been hampered by uncertainty over the molecular identity of cardiac Na(+)/HCO(3)(-) co-transporter(s) and the absence of selective pharmacological inhibitors. In their paper published in this issue, Ch'en and colleagues describe the extensive characterization of S0859 as a high-affinity inhibitor of Na(+)/HCO(3)(-) co-transport in cardiac myocytes (Ch'en et al., 2008). The availability of S0859 provides a powerful new tool to investigate the (patho)physiological significance of Na(+)/HCO(3)(-) co-transport in the heart and other tissues.
Avkiran
M
M
King's College London, Cardiovascular Division, St Thomas' Hospital, London, UK. metin.ackiran@kcl.ac.uk
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001692:Biological Transport; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D017202:Myocardial Ischemia / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000037:antagonists & inhibitors* / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology*
D001549:Benzamides; C528718:S 0859 compound; D027982:Sodium-Bicarbonate Symporters; D013449:Sulfonamides