Impaired cervical homeostasis upon selective ablation of RXRalpha in epithelial cells.
Retinoids play critical regulatory roles in the maintenance of mammalian epithelia and exert pleiotropic effects through nuclear receptors. RXRalpha, which is a ligand-dependent transcription factor, is the most abundant RXR isotype expressed in cervical epithelia, and may play a crucial role in cervix development and homeostasis. We have previously described a mouse model to induce the temporally controlled epithelia-specific somatic mutagenesis of RXRalpha alleles in epidermis. To study the role of RXRalpha in cervical homeostasis, we ablated RXRalpha in cervix epithelial cells of adult mice. We found that such mutant mice develop ectocervical atrophy with moderate epidermoid metaplasia. In addition, we report a simultaneous increase of cell proliferation and apoptosis levels accompanied by alteration in the expression of genes involved in both processes.
Ocadiz-Delgado
R
R
Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico.
Castaneda-Saucedo
E
E
Indra
A K
AK
Hernandez-Pando
R
R
Gariglio
P
P
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D002584:Cervix Uteri / Q000502:physiology*; D004817:Epidermis / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006706:Homeostasis; D008024:Ligands; D051379:Mice; D008817:Mice, Mutant Strains; D016296:Mutagenesis; D009154:Mutation; D047490:Retinoid X Receptor alpha / Q000235:genetics* / Q000502:physiology*
D008024:Ligands; D047490:Retinoid X Receptor alpha