title: A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2.
abstract: The non-classical human leucocyte antigen (HLA) class I locus, HLA-G, shows a low protein polymorphism and a more varied DNA (eight proteins and 28 alleles). HLA-G DNA polymorphism accounts mainly for changes at third codon bases of the protein coding exons; this does not imply amino acid change in most cases. This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G.
authors.affiliation: Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain. aarnaiz@med.ucm.es
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: J I
authors.initials: JI
authors.lastname: Serrano-Vela
authors.forename: R
authors.initials: R
authors.lastname: Reguera
authors.forename: B
authors.initials: B
authors.lastname: Perez-Saborido
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005091:Exons; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D009626:Terminology as Topic
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D004247:DNA