title: Pressures generated within the chambers of the MagScrew TAH: an in vitro study.
abstract: Incompetent inflow valves have been reported with clinical pulsatile left ventricular assist devices that use bioprosthetic valves. Suspected as the cause of premature valve failure within these devices, absolute pressures and instantaneous pressure changes were evaluated in the MagScrew total artificial heart (TAH). The MagScrew TAH is a passively filling pulsatile pump which uses a reciprocating magnetic actuating mechanism under various control modes to propel blood into circulation. Both right and left ejection speeds were modulated and optimized at the onset of hydraulic eject. These various speed profiles were evaluated in vitro at 220 beats per minute (bpm), 100% pump fill, mean aortic pressure of 100 mm Hg and mean pulmonary artery pressure of 20 mm Hg. The pressure inside the left and right pump chambers was measured with Millar Mikro-Tip catheter and captured using Power Lab at a rate of 40 kHz. The pump chamber peak pressure, operating with unmodified eject speeds, measured on average 183 mm Hg for the left and 133 mm Hg for the right. Eject speed profiling for both pumps reduced the peak pressure by 10% and 28% for the left and right pump, respectively. Future studies will assess software controlled optimization of the eject speed profiles under any operating condition and how effective it is in vivo.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Christine R
authors.initials: CR
authors.lastname: Flick
authors.forename: Stephan
authors.initials: S
authors.lastname: Weber
authors.forename: Viviane
authors.initials: V
authors.lastname: Luangphakdy
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Klatte
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: William A
authors.initials: WA
authors.lastname: Smith
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D004867:Equipment Design; D006339:Heart Rate; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D009991:Oscillometry; D011312:Pressure; D011474:Prosthesis Design; D012984:Software; D013314:Stress, Mechanical