title: Neurologic dysfunction in hypothyroid, hyperlipidemic Labrador Retrievers.
abstract: BACKGROUND
  Hypothyroidism has been associated with a variety of neurologic signs, but the mechanism for this association is not completely understood. Hypothyroidism also is associated with hyperlipidemia that predisposes to atherosclerosis, increased blood viscosity, and thromboembolic events.
  
  
  OBJECTIVE
  The objective is to characterize neurologic signs potentially associated with hyperlipidemia and atherosclerosis in canine hypothyroidism.
  
  
  METHODS
  This study used dogs referred to North Carolina State University Veterinary Teaching Hospital for evaluation of neurologic signs.
  
  
  METHODS
  A retrospective study was conducted in which medical records of dogs with neurologic signs and a diagnosis of hypothyroidism and hyperlipidemia were reviewed. Details of the history, presenting signs, results of routine blood tests, thyroid tests, cerebrospinal fluid (CSF) analysis and diagnostic imaging, and response to therapy were compiled.
  
  
  RESULTS
  Three Labrador Retrievers and one Labrador Retriever cross fit the inclusion criteria. All dogs were hypothyroid and severely hyperlipidemic. Neurologic signs included tetraparesis, central and peripheral vestibular signs, facial paralysis, and paraparesis. Two dogs had an acute history and rapid resolution of signs consistent with an infarct, the presence of which was confirmed in 1 of the dogs by magnetic resonance imaging. Two dogs had chronic histories of cranial neuropathies and paraparesis. One of these dogs had evidence of iliac thrombosis and atherosclerosis on ultrasound examination. All dogs improved with thyroid hormone supplementation.
  
  
  CONCLUSIONS
  Labrador Retrievers may be predisposed to the development of severe hyperlipidemia in association with hypothyroidism. One possible consequence of severe hyperlipidemia is the development of neurologic signs due to atherosclerosis and thromboembolic events.
authors.affiliation: University of Missouri, Columbia Veterinary Medical Teaching Hospital, 4700 Hillsborough St, Raleigh, NC 27592, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Vitale
authors.forename: Natasha J
authors.initials: NJ
authors.lastname: Olby
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000662:veterinary; D002493:Central Nervous System Diseases / Q000150:complications / Q000662:veterinary*; D004285:Dogs; D005260:Female; D006949:Hyperlipidemias / Q000150:complications / Q000662:veterinary*; D007037:Hypothyroidism / Q000150:complications / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies