title: Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration.
abstract: Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD. In order to investigate the association of this HTRA1 polymorphism and the bilaterality of AMD, we genotyped rs11200638 in control, unilateral, and bilateral advanced AMD patients. The A allele for SNP rs11200638 in HTRA1, was significantly more prevalent in bilateral wet AMD and GA patients than in unilateral groups (p=.02 and p=.03, respectively). The homozygote odds ratios of bilateral wet AMD and GA are significantly greater than those seen in unilateral groups (twofold and threefold increase, respectively). This finding is consistent with the role of HTRA1 in AMD pathogenesis and will help aid in the clinical management and prognosis of AMD patients.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Haoyu
authors.initials: H
authors.lastname: Chen
authors.forename: Zhenglin
authors.initials: Z
authors.lastname: Yang
authors.forename: Daniel
authors.initials: D
authors.lastname: Gibbs
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.forename: Vincent
authors.initials: V
authors.lastname: Hau
authors.forename: Peiquan
authors.initials: P
authors.lastname: Zhao
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Jiexi
authors.initials: J
authors.lastname: Zeng
authors.forename: Ling
authors.initials: L
authors.lastname: Luo
authors.forename: Erik
authors.initials: E
authors.lastname: Pearson
authors.forename: Ryan
authors.initials: R
authors.lastname: Constantine
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Kaminoh
authors.forename: Jennifer
authors.initials: J
authors.lastname: Harmon
authors.forename: Zongzhong
authors.initials: Z
authors.lastname: Tong
authors.forename: Charity A
authors.initials: CA
authors.lastname: Stratton
authors.forename: D Joshua
authors.initials: DJ
authors.lastname: Cameron
authors.forename: Shibo
authors.initials: S
authors.lastname: Tang
authors.forename: Kang
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D000074289:High-Temperature Requirement A Serine Peptidase 1; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D000074289:High-Temperature Requirement A Serine Peptidase 1; C474012:HTRA1 protein, human; D012697:Serine Endopeptidases