title: Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials.
abstract: The application of deep brain stimulation (DBS) for the treatment of Parkinson's disease offered a direct "insight" into the human electrical activity in subcortical structures. The analysis of the oscillatory activity [local field potentials (LFPs)] disclosed the importance of rhythms and of interactions between rhythms in the human basal ganglia information processing. The aim of this study was to investigate the existence of possible nonlinear interactions between LFP rhythms characterizing the output structure of the basal ganglia, the globus pallidus internus, by means of bispectral analysis. The results of this study disclosed that the rhythms expressed in the globus pallidus internus of the untreated parkinsonian patient are not independent and, in particular, the low-beta (13-20 Hz) band generates harmonics that are included in the high-beta (20-35 Hz) band. Conversely, in the dystonic globus pallidus, as well as in the parkinsonian globus pallidus after dopaminergic medication (i.e., in the more "normal" condition), the rhythms are substantially independent and characterized by a strong activity in the low-frequency band that generates a second harmonic (4-14 Hz), mostly included in the same band. The interactions between rhythms in the human globus pallidus are therefore different in different pathologies and in different patient's states. The interpretation of these interactions is likely critical for fully understanding the role of LFP rhythms in the pathophysiology of human basal ganglia.
authors.affiliation: Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Milan, Italy. sara.marceglia@policlinico.mi.it
authors.forename: Sara
authors.initials: S
authors.lastname: Marceglia
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Bianchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Baselli
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Foffani
authors.forename: Filippo
authors.initials: F
authors.lastname: Cogiamanian
authors.forename: Nicola
authors.initials: N
authors.lastname: Modugno
authors.forename: Simona
authors.initials: S
authors.lastname: Mrakic-Sposta
authors.forename: Alberto
authors.initials: A
authors.lastname: Priori
authors.forename: Sergio
authors.initials: S
authors.lastname: Cerutti
mesh_terms: D001479:Basal Ganglia / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000503:physiopathology; D004569:Electroencephalography; D005071:Evoked Potentials; D005917:Globus Pallidus / Q000503:physiopathology; D006801:Humans; D009991:Oscillometry; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D012016:Reference Values