title: Rift Valley fever outbreak with East-Central African virus lineage in Mauritania, 2003.
abstract: In October 2003, 9 human cases of hemorrhagic fever were reported in 3 provinces of Mauritania, West Africa. Test results showed acute Rift Valley fever virus (RVFV) infection, and a field investigation found recent circulation of RVFV with a prevalence rate of 25.5% (25/98) and 4 deaths among the 25 laboratory-confirmed case-patients. Immunoglobulin M against RVFV was found in 46% (25/54) of domestic animals. RVFV was also isolated from the mosquito species Culex poicilipes. Genetic comparison of virion segments indicated little variation among the strains isolated. However, phylogenetic studies clearly demonstrated that these strains belonged to the East-Central African lineage for all segments. To our knowledge, this is the first time viruses of this lineage have been observed in an outbreak in West Africa. Whether these strains were introduced or are endemic in West Africa remains to be determined.
authors.affiliation: Institut Pasteur de Dakar, Dakar, Sénégal.
authors.forename: Ousmane
authors.initials: O
authors.lastname: Faye
authors.forename: Mawlouth
authors.initials: M
authors.lastname: Diallo
authors.forename: Djibril
authors.initials: D
authors.lastname: Diop
authors.forename: O Elmamy
authors.initials: OE
authors.lastname: Bezeid
authors.forename: Hampathé
authors.initials: H
authors.lastname: Bâ
authors.forename: Mbayame
authors.initials: M
authors.lastname: Niang
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Dia
authors.forename: Sid Ahmed Ould
authors.initials: SA
authors.lastname: Mohamed
authors.forename: Kader
authors.initials: K
authors.lastname: Ndiaye
authors.forename: Diawo
authors.initials: D
authors.lastname: Diallo
authors.forename: Peinda Ogo
authors.initials: PO
authors.lastname: Ly
authors.forename: Boubacar
authors.initials: B
authors.lastname: Diallo
authors.forename: Pierre
authors.initials: P
authors.lastname: Nabeth
authors.forename: François
authors.initials: F
authors.lastname: Simon
authors.forename: Baïdy
authors.initials: B
authors.lastname: Lô
authors.forename: Ousmane Madiagne
authors.initials: OM
authors.lastname: Diop
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003465:Culex / Q000821:virology*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D014644:Genetic Variation; D006041:Goats; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007303:Insect Vectors / Q000821:virology*; D008297:Male; D008435:Mauritania / Q000453:epidemiology; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D012295:Rift Valley Fever / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission / Q000821:virology; D012296:Rift Valley fever virus / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D016036:Seroepidemiologic Studies; D012756:Sheep; D015047:Zoonoses
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D012367:RNA, Viral