title: [Application and evaluation of biologic potential grading criteria for localized gastrointestinal stromal tumors].
abstract: OBJECTIVE
  To evaluate the implication of Fletcher and Miettinen biologic potential grading criteria in native localized gastrointestinal stromal tumors (GISTs).
  
  
  METHODS
  Two hundred and twenty localized GISTs with complete clinicopathologic and follow-up data were evaluated for their biologic potential by Fletcher and Miettinen grading criteria. The implication of the two grading criteria were compared by survival analysis.
  
  
  RESULTS
  Evaluated by Fletcher grading criteria, the overall and disease-free survival rate of high risk GISTs was lower than that of very-low, low and intermediate GISTs; while the overall and disease-free survival rate of very-low, low and intermediate risk GISTs had no statistical diffence. In the high risk GISTs, the overall and disease-free survival rate of small intestinal and rectal GISTs was lower than that of gastric GISTs; while in the intermediate risk GISTs, the disease-free survival rate of small intestinal GISTs was lower than that of gastric GISTs. Evaluated by Miettinen grading criteria, the overall and disease-free survival rate of high risk GISTs was lower than that of very-low, low and intermediate GISTs; while the overall and disease-free survival rate of very-low, low and intermediate risk GISTs had no statistical difference. In the risk subgroup of GISTs, the overall and disease-free survival rate of gastric, small intestinal and rectal GISTs had no statistical difference.
  
  
  CONCLUSIONS
  Fletcher grading criteria is simple and easy to use; while Miettinen grading criteria for evaluating biological potential by anatomic site is more critical and has important reference implication for the selection of high risk patients for targeted adjuvant treatment.
authors.affiliation: Department of Pathology, Cancer Hospital Affiliated to Fudan University, and Department of Oncology, Fudan University Shanghai Medical College, Shanghai 200032, China.
authors.forename: En-yi
authors.initials: EY
authors.lastname: Shi
authors.forename: Ying-yong
authors.initials: YY
authors.lastname: Hou
authors.forename: Yun-shan
authors.initials: YS
authors.lastname: Tan
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Zhou
authors.forename: Xu
authors.initials: X
authors.lastname: Cai
authors.forename: Yong-ming
authors.initials: YM
authors.lastname: Lu
authors.forename: Xiong-zeng
authors.initials: XZ
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D007580:Jejunal Neoplasms / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000473:pathology*; D018570:Risk Assessment / Q000379:methods / Q000592:standards*; D013274:Stomach Neoplasms / Q000473:pathology*; D015996:Survival Rate; D055815:Young Adult