Informatics and computational strategies for the study of lipids.
Recent advances in mass spectrometry (MS)-based techniques for lipidomic analysis have empowered us with the tools that afford studies of lipidomes at the systems level. However, these techniques pose a number of challenges for lipidomic raw data processing, lipid informatics, and the interpretation of lipidomic data in the context of lipid function and structure. Integration of lipidomic data with other systemic levels, such as genomic or proteomic, in the context of molecular pathways and biophysical processes provides a basis for the understanding of lipid function at the systems level. The present report, based on the limited literature, is an update on a young but rapidly emerging field of lipid informatics and related pathway reconstruction strategies.
Yetukuri
Laxman
L
VTT Technical Research Centre of Finland, Tietotie 2, FI-02044 VTT, Espoo, Finland.
Ekroos
Kim
K
Vidal-Puig
Antonio
A
Oresic
Matej
M
D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis / Q000737:chemistry
D008055:Lipids