title: Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis.
abstract: Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.
authors.affiliation: INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur, 86000 Poitiers, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lefeuvre
authors.forename: Sandrine
authors.initials: S
authors.lastname: Marchand
authors.forename: Claudine
authors.initials: C
authors.lastname: Pariat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lamarche
authors.forename: William
authors.initials: W
authors.lastname: Couet
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001202:Ascitic Fluid / Q000737:chemistry / Q000378:metabolism*; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D017551:Microdialysis; D010195:Pancreatitis / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem