title: Renal Behçet's disease: an update.
abstract: OBJECTIVE
  The aims of this study are (1) to report 33 patients with Behçet's disease (BD) having various renal manifestations, and (2) to update current data using our patients and published papers about BD and renal manifestations.
  
  
  METHODS
  The PubMed database was searched using the terms BD or Behçet's syndrome. We found reports of 94 patients (including ours) with BD and specific renal diseases (amyloidosis, 39; glomerulonephritis [GN], 37; renal vascular disease, 19; interstitial nephritis, 1).
  
  
  RESULTS
  The presentation of renal disease was edema/nephrotic syndrome in 12 patients (36%). Renal disease was incidentally diagnosed by routine urine analysis and measurement of serum creatinine level in 20 patients (61%). Renal failure was present in 23 patients (70%) and 5 of them have had cyclosporine treatment. The frequency of renal disease among BD patients has been reported to vary from less than 1 to 29%.
  
  
  CONCLUSIONS
  The clinical spectrum of renal BD shows a wide variation. Amyloidosis (AA type), GN, and macroscopic/microscopic vascular disease are the main causes of renal BD. Patients with vascular involvement have a high risk of amyloidosis and amyloidosis is the most common cause of renal failure in BD. Several types of glomerular lesions are seen in BD. Current treatment options for renal BD are not evidence based. Radiological vascular intervention combined with immunosuppressive drugs can be useful in selected cases. Routine urine analysis and measurement of serum creatinine level are needed for early diagnosis of renal BD.
authors.affiliation: Ondokuz Mayis University School of Medicine, Samsun, Turkey. tekinakpolat@yahoo.com
authors.forename: Tekin
authors.initials: T
authors.lastname: Akpolat
authors.forename: Melda
authors.initials: M
authors.lastname: Dilek
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.forename: Gökhan
authors.initials: G
authors.lastname: Keser
authors.forename: Omer
authors.initials: O
authors.lastname: Toprak
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cirit
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Oğuz
authors.forename: Hülya
authors.initials: H
authors.lastname: Taşkapan
authors.forename: Zelal
authors.initials: Z
authors.lastname: Adibelli
authors.forename: Harun
authors.initials: H
authors.lastname: Akar
authors.forename: Bülent
authors.initials: B
authors.lastname: Tokgöz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arici
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Celiker
authors.forename: Banu
authors.initials: B
authors.lastname: Diri
authors.forename: Ilkser
authors.initials: I
authors.lastname: Akpolat
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis; D003404:Creatinine / Q000097:blood; D004487:Edema / Q000175:diagnosis / Q000209:etiology / Q000652:urine; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged
chemical_list: D003404:Creatinine