Combretastatin a-4 analogs as anticancer agents.
Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.
Chaudhary
Anurag
A
Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, U.P., India. anurag15182@rediffmail.com
Pandeya
S N
SN
Kumar
P
P
Sharma
P P
PP
Gupta
S
S
Soni
N
N
Verma
K K
KK
Bhardwaj
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D013267:Stilbenes; C058728:fosbretabulin