Gadolinium-induced nephrotoxicity.
Because of the well-documented risk of acute renal failure with the iodinated contrast media in patients with underlying chronic renal insufficiency, the use of intravenous gadolinium-based contrast media in magnetic resonance imaging for diagnostic and interventional radiology procedures has become a well-established clinical practice in the recent years. Although originally thought to be safe and lack the nephrotoxic effects of iodinated contrast media, gadolinium-based contrast media have recently been reported to induce a usually reversible decrease of glomerular filtration rate in a high-risk population group, especially in patients with altered baseline renal function. Here we present the current experimental and clinical evidence on this new challenge for the nephrologist, gadolinium-induced nephrotoxicity in patients with chronic kidney disease.
Buhaescu
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Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA. irina.buhaescu@stvincenthospital.com
Izzedine
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D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects; D005682:Gadolinium / Q000009:adverse effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D051436:Renal Insufficiency, Chronic / Q000150:complications
D003287:Contrast Media; D005682:Gadolinium