Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B.
The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineralization. As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow.
Weenig
Roger H
RH
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. weenig.roger@mayo.edu
D000818:Animals; D001862:Bone Resorption / Q000378:metabolism; D002113:Calcification, Physiologic; D002115:Calciphylaxis / Q000209:etiology* / Q000266:history / Q000378:metabolism / Q000628:therapy; D002118:Calcium / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D008024:Ligands; D016328:NF-kappa B / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D014481:United States; D014652:Vascular Diseases / Q000209:etiology
D008024:Ligands; D016328:NF-kappa B; D010281:Parathyroid Hormone; D010710:Phosphates; D011956:Receptors, Cell Surface; D002118:Calcium