title: Palladium-catalyzed one-pot synthesis of 2-alkyl-2-arylcyanoacetates.
abstract: A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)2/DPPF (DPPF = 1,1'-diphenylphosphino ferreocene)-catalyzed enolate arylation followed by in situ alkylation has been developed. This procedure tolerates a diverse range of aryl and heteroaryl bromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.
authors.affiliation: Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. xiangw@amgen.com
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Anil
authors.initials: A
authors.lastname: Guram
authors.forename: Emilio
authors.initials: E
authors.lastname: Bunel
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Cao
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Allen
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*
chemical_list: D000085:Acetates; D010165:Palladium