title: Pregnancy complicated with chronic myelogeneous leukemia (CML) successfully treated with imatinib: a case report.
abstract: Pregnancy and cancer is a complex situation. The coincidence of chronic myelogeneous leukemia (CML) and pregnancy is an uncommon event, in part because CML occurs mostly in older age groups. The management of CML during pregnancy is a difficult problem because of the potential effects of the therapy on the mother and fetus. Imatinib is a relatively new drug in this era and it induces dramatic hematologic and cytogenetic responses in CML but it is not recommended for use during pregnancy or if the patient plans to conceive. In the literature there are very few reports of outcome of pregnancy conceived while on imatinib. In this report, we describe a successful pregnancy and labor under treatment of imatinib in a patient who was diagnosed with CML at the beginning of her pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. esraesim@yahoo.com
authors.forename: Esra Esim
authors.initials: EE
authors.lastname: Buyukbayrak
authors.forename: Bahar
authors.initials: B
authors.lastname: Ergen
authors.forename: Yasemin Karageyim
authors.initials: YK
authors.lastname: Karsidag
authors.forename: Bulent
authors.initials: B
authors.lastname: Kars
authors.forename: Cem
authors.initials: C
authors.lastname: Turan
authors.forename: Dilek
authors.initials: D
authors.lastname: Argon
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate