title: Memantine and NMDA antagonism for chronic migraine: a potentially novel therapeutic approach?
abstract: We present the case of a woman with chronic migraine who unexpectedly reported full remission of headache after memantine, an NMDA receptor antagonist, was administered for treating concomitant mild cognitive impairment. An underlying dose-dependent effect of memantine on headache symptoms in chronic daily headache and chronic migraine could be assumed.
authors.affiliation: Department of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Spengos
authors.forename: Christos
authors.initials: C
authors.lastname: Theleritis
authors.forename: Thomas
authors.initials: T
authors.lastname: Paparrigopoulos
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008559:Memantine / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D008559:Memantine