title: [The role of hormones of hypothalamic-pituitary-adrenocortical system in regulation of pain sensitivity].
abstract: The review focuses on the role of hypothalamic-pituitary-adrenocortical system (HPAS) in regulation of pain sensitivity and discusses the mechanisms involved in this process. Analgesic effects of exogenous hormones of HPAS (corticotropin-releasing hormone (CRH), ACTH, glucocorticoids) have been shown in rats. It is mediated by both opioid and non-opioid mechanisms. Endogenous glucocorticoids produce development of analgesia mediated by non-opioid mechanisms. Analgesic effect of ACTH is mediated by both non-glucocorticoids mechanisms associated with endogenous glucocorticoids and opioid mechanisms. In contrast to ACTH, analgesic effect of CRH is mediated only by non-opioid mechanisms associated or dissociated with endogenous glucocorticoids. The neurons of midbrain periaqueductal gray matter may be involved in the analgesia induced by glucocorticoids.
authors.forename: N I
authors.initials: NI
authors.lastname: Iarushkina
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000700:Analgesics / Q000378:metabolism*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism* / Q000473:pathology; D010146:Pain / Q000378:metabolism* / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000378:metabolism* / Q000473:pathology; D051381:Rats
chemical_list: D000700:Analgesics; D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone