title: Fragmentation reactions of singly and doubly protonated thiourea- and sugar-substituted cyclams and their transition-metal complexes.
abstract: Cyclam macrocycles tetrasubstituted with amino-, thiourea-, and sugar-terminated side chains are ionized by electrospray ionization mass spectrometry (ESI-MS) as singly or doubly protonated species or as transition-metal complexes. Their fragmentation behavior is examined in a Fourier-transform ion-cyclotron-resonance (FT-ICR) mass spectrometer by collision-induced dissociation (CID) experiments. Typically, fragmentation occurs within the side chains through a number of different 1,2-elimination reactions irrespective of the absence or presence of a transition metal ion such as Co(2+), Ni(2+), or Zn(2+). A remarkable exception is Cu(2+), which induces ring cleavage reactions. This is traced back to an electron transfer from the cyclam nitrogen atoms to the Cu(2+) ion. The electron transfer creates a cation-radical within the macrocycle, which induces typical fragmentation reactions such as alpha-cleavages that lead to fragmentation within the macrocycle. This interpretation is in line with fragmentation experiments on unsubstituted cyclam and its complexes.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie der Universität, Bonn, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Felder
authors.forename: Anika
authors.initials: A
authors.lastname: Röhrich
authors.forename: Holger
authors.initials: H
authors.lastname: Stephan
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Schalley
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D047029:Lactams, Macrocyclic / Q000737:chemistry*; D011522:Protons; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013890:Thiourea / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D047029:Lactams, Macrocyclic; D011522:Protons; D028561:Transition Elements; D013890:Thiourea