[Assessment of selected haemostatic parameters in obese patients].
BACKGROUND
Epidemiologic data show significantly higher frequency of thromboembolic incidents in obesity than in normal weight persons. Disorders of haemostasis seem to play a crucial role in their development. In the literature there are only few papers assessing coagulation and fibrynolitic parameters in obese subjects.


OBJECTIVE
Assessment of protein C (PC), antithrombin (AT) and alpha2 antiplasmin (alpha2AP) activity and thrombomodulin (TM) concentration in the blood plasma of obese person (BMI > 30 kg/m(2)).


METHODS
The study involved 32 patients (22 women and 10 men, mean age 39.7 +/- 15.3 years) and 20 healthy volunteers matched correctly according to sex and age who constituted a control group. In the examined subjects activity of PC, AT, alpha2 AP were assessed by means of the colorimetric methods and TM concentration in the blood plasma using ELISA method.


RESULTS
No statistically significant differences in activities of PC, AT, alpha2 AP and TM concentrations between the patients and the control group were found. However the tendency to higher activities of PC and concentrations of TM were noticed in the obese patients. Assessing tested parameters according to sex, statistically significant differences were found in AT activity between the male patients and healthy men. Statistically lower values, but still in the normal range, were found in the obese men. Comparing the groups of women, significantly lower concentrations of TM were found in the obese ones.


CONCLUSIONS
It seems that changed values of PC, AT, alpha2 AP activities are not responsible for increased risk of thromboembolic events in obese persons. Increased TM concentration in obese, may indirectly indicate endothelium damage.
Swiatkowska-Stodulska
Renata
R
Klinika Endokrynologii i Chorób Wewnetrznych Instytutu Chorób Wewnetrznych Akademii Medycznej, Gdańsk. rensto@amg.gpa.pl
Skibowska-Bielińska
Anna
A
Bakowska
Alicja
A
Wiśniewski
Piotr
P
Sworczak
Krzysztof
K
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005337:Fibrin / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011486:Protein C / Q000032:analysis*; D013923:Thromboembolism / Q000097:blood*; D018180:Thrombomodulin / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis*
D011486:Protein C; D018180:Thrombomodulin; D000979:alpha-2-Antiplasmin; D005337:Fibrin