Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis.
BACKGROUND
Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleurisy. We conducted a meta-analysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy.


METHODS
After a systematic review of English language studies, sensitivity, specificity, and other measures of accuracy of ADA concentration in the diagnosis of pleural effusion were pooled using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance.


RESULTS
Sixty-three studies met our inclusion criteria. The summary estimates for ADA in the diagnosis of tuberculous pleurisy in the studies included were sensitivity 0.92 (95% confidence interval 0.90-0.93), specificity 0.90 (95% confidence interval 0.89-0.91), positive likelihood ratio 9.03 (95% confidence interval 7.19-11.35), negative likelihood ratio 0.10 (95% confidence interval 0.07-0.14), and diagnostic odds ratio 110.08 (95% confidence interval 69.96-173.20).


CONCLUSIONS
ADA determination is a relative sensitive and specific test for the diagnosis of tuberculous pleurisy. Measurement of ADA in pleural effusion is thus likely to be a useful diagnostic tool for tuberculous pleurisy. The results of ADA assays should be interpreted in parallel with clinical findings and the results of conventional tests.
Liang
Qiu-Li
QL
Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, People's Republic of China.
Shi
Huan-Zhong
HZ
Wang
Ke
K
Qin
Shou-Ming
SM
Qin
Xue-Jun
XJ
D000243:Adenosine Deaminase / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D004796:Clinical Enzyme Tests; D006801:Humans; D009169:Mycobacterium tuberculosis; D016017:Odds Ratio; D010996:Pleural Effusion / Q000201:enzymology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014396:Tuberculosis, Pleural / Q000175:diagnosis*
D015415:Biomarkers; D000243:Adenosine Deaminase