Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin.
Futamura
Yushi
Y
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Sawa
Ryuichi
R
Umezawa
Yoji
Y
Igarashi
Masayuki
M
Nakamura
Hikaru
H
Hasegawa
Kimiko
K
Yamasaki
Mikio
M
Tashiro
Etsu
E
Takahashi
Yoshikazu
Y
Akamatsu
Yuzuru
Y
Imoto
Masaya
M
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013302:Streptomyces / Q000187:drug effects*; D051020:bcl-X Protein / Q000037:antagonists & inhibitors* / Q000235:genetics
D000970:Antineoplastic Agents; C494811:BCL2L1 protein, human; D004187:Disaccharides; D007769:Lactams; D051020:bcl-X Protein; C527896:incednine; D004317:Doxorubicin