[Chronic Chagas disease patients with sinus node dysfunction: is the presence of IgG antibodies with muscarinic agonist action independent of left ventricular dysfunction?].
Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.
Altschüller
Maria Beatriz Corrêa de Mello
MB
Serviço de Cardiologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ. mba@hucff.ufrj.br
Pedrosa
Roberto Coury
RC
Pereira
Basílio de Bragança
Bde B
Corrêa Filho
Wilson Braz
WB
Medeiros
Aline Silva de
AS
Costa
Patrícia Cristina Santos
PC
de Carvalho
Antonio Carlos Campos
AC
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D002598:Chagas Cardiomyopathy / Q000276:immunology* / Q000503:physiopathology; D002908:Chronic Disease; D004562:Electrocardiography; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000378:metabolism; D016014:Linear Models; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000097:blood* / Q000378:metabolism; D043585:Receptor, Muscarinic M2 / Q000819:agonists / Q000097:blood*; D012849:Sinoatrial Node / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D018721:Muscarinic Agonists; D043585:Receptor, Muscarinic M2