The magic of the hypoxia-signaling cascade.
All organisms respond to changes in their environment by activating complex signaling cascades. The "hypoxia-signaling cascade" is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.
Benizri
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CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, Nice, France.
Ginouvès
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Berra
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D000818:Animals; D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism / Q000628:therapy; D015316:Genetic Therapy; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000150:complications / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1