Adulterated effects of nitric oxide-generating donors.
Impaired cutaneous nitric oxide (NO) production is associated with diminished antioxidative capacity in skin cells, hindered wound healing, unbalanced inflammatory reactions, and disturbed immunological responses. Use of topically applied NO donors might represent an auspicious new therapeutic approach in the field of dermatology. But what is the appropriate NO-generating compound or system? In this issue, Mowbray et al. describe a new chemical inert NO donor that per se produces little inflammation in the skin.
Kröncke
Klaus-D
KD
Institute of Biochemistry and Molecular Biology I, Medical Department of the Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.
Suschek
Christoph V
CV
D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000627:therapeutic use*; D012867:Skin / Q000378:metabolism*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D020030:Nitric Oxide Donors; D009569:Nitric Oxide