title: What next for preimplantation genetic screening?
abstract: Preimplantation genetic diagnosis for aneuploidy screening (preimplantation genetic screening-PGS) has been used to detect chromosomally normal embryos from subfertile patients. The main indications are advanced maternal age (AMA), repeated implantation failure, repeated miscarriages and severe male factor infertility. Many non-randomized PGS studies have been published and report an increase in implantation rate, and/or a decrease in miscarriage rate. Recently, two randomized controlled trials have been conducted on patients with AMA as the only indication. Neither study showed a benefit in performing PGS using live birth rate as the measure of success. The debate on the usefulness of PGS is ongoing; the only effective way to resolve the debate is to perform more well-designed and well-executed randomized clinical trials.
authors.affiliation: UCL Centre for PGD, Institute for Women's Health, University College London, 86-96 Chenies Mews, WC1E6HX London, UK. joyce.harper@ucl.ac.uk
authors.forename: Joyce
authors.initials: J
authors.lastname: Harper
authors.forename: Karen
authors.initials: K
authors.lastname: Sermon
authors.forename: Joep
authors.initials: J
authors.lastname: Geraedts
authors.forename: Katerina
authors.initials: K
authors.lastname: Vesela
authors.forename: Gary
authors.initials: G
authors.lastname: Harton
authors.forename: Alan
authors.initials: A
authors.lastname: Thornhill
authors.forename: Tugce
authors.initials: T
authors.lastname: Pehlivan
authors.forename: Francesco
authors.initials: F
authors.lastname: Fiorentino
authors.forename: Sioban
authors.initials: S
authors.lastname: SenGupta
authors.forename: Christine
authors.initials: C
authors.lastname: de Die-Smulders
authors.forename: Cristina
authors.initials: C
authors.lastname: Magli
authors.forename: Celine
authors.initials: C
authors.lastname: Moutou
authors.forename: Leeanda
authors.initials: L
authors.lastname: Wilton
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D008423:Maternal Age; D019836:Preimplantation Diagnosis