An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus).
Histiocytic sarcoma is the most frequent hematopoietic tumor in rats. We report here a histiocytic sarcoma infiltrating the liver, the spleen and the pancreas from a Wistar rat. In the liver, the tumor was associated with oval cell and bile duct hyperplasia. The cells looked like neoplastic histocytic cells described in this species but with some particularities (e.g. lack of multinucleated giant cells). At immunohistochemistry, neoplastic cells in the liver were vimentine positive but lysozyme and CD68 negative. In the kidney, lysozyme-positive cytoplasmic droplets were observed. We describe here an atypical case of histiocytic sarcoma in the rat and we compare the nature of these neoplastic cells to other species.
Bauchet
Anne-Laure
AL
Department of Pathology, Veterinary School of Alfort, 7 Avenue du Général de Gaulle, 94704 Maisons-Alfort, France.
Fouque
Marie-Claude
MC
Belluco
Sara
S
Château-Joubert
Sophie
S
Elies
Laetitia
L
Maliver
Pierre
P
Schorsch
Frédéric
F
Fontaine
Jean-Jacques
JJ
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D054747:Histiocytic Sarcoma / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000096:biosynthesis; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000096:biosynthesis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009113:Muramidase; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule