Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions.
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.
Leadbeater
Nicholas E
NE
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA. nicholas.leadbeater@uconn.edu
Schmink
Jason R
JR
D000090:Acetoacetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis*; D008872:Microwaves; D012984:Software; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods*; D013696:Temperature
D000090:Acetoacetates; D000447:Aldehydes; D003374:Coumarins; C013243:salicylaldehyde; C094809:3-acetylcoumarin; C024840:ethyl acetoacetate