[Determination of buprenorphine in urine].
Buprenorphine is one of the drugs used for treatment of opioid-dependent patients enrolled in rehabilitation programs in Norway. Buprenorphine is metabolized in the liver by cytochrome P450 to the active metabolite norbuprenorphine, and further to buprenorphine-glucuronide and norbuprenorphine-glucuronide. The Division of Forensic Toxicology and Drug Abuse at the Norwegian Institute of Public Health has during the past 5 years received an increasing number of urine samples for buprenorphine analysis. All urine samples with question of buprenorphine have since August 2005 been analysed with a new method, which analyses the glucuronides of buprenorphine and norbuprenorphine in urine. This method is fast and simple and saves time and resources in our routine laboratory.
Hegstad
Solfrid
S
Nasjonalt folkehelseinstitutt, Divisjon for rettstoksikologi og rusmiddelforskning, Postboks 4404 Nydalen, 0403 Oslo. solfrid.hegstad@fhi.no
Christophersen
Asbjørg S
AS
Khiabani
Hassan Z
HZ
D002047:Buprenorphine / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine*; D053593:Forensic Toxicology / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D020719:Glucuronides / Q000652:urine; D006801:Humans; D007118:Immunoassay / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D009292:Narcotic Antagonists / Q000652:urine*; D009294:Narcotics / Q000652:urine*; D012680:Sensitivity and Specificity
D020719:Glucuronides; D009292:Narcotic Antagonists; D009294:Narcotics; D002047:Buprenorphine; C043585:norbuprenorphine