Trading translation with RNA-binding proteins.
RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins. By using a specific set of well-defined examples, we also describe how regulation can be reversed.
Abaza
Irina
I
Centre de Regulació Genòmica, Gene Regulation Programme, 08003 Barcelona, Spain.
Gebauer
Fátima
F
D000818:Animals; D020868:Gene Silencing; D008954:Models, Biological; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism
D012315:RNA Caps; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012097:Repressor Proteins