Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light.
The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (.OH, O2. -, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda>455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.
Jańczyk
Agnieszka
A
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
Wolnicka-Głubisz
Agnieszka
A
Urbanska
Krystyna
K
Kisch
Horst
H
Stochel
Grazyna
G
Macyk
Wojciech
W
D000818:Animals; D045744:Cell Line, Tumor; D008027:Light; D051379:Mice; D009336:Necrosis / Q000378:metabolism; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017671:Platinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D019097:Spin Trapping; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
D017319:Photosensitizing Agents; D017671:Platinum Compounds; D017382:Reactive Oxygen Species; C030173:platinum chloride; C009495:titanium dioxide; D014025:Titanium