[The experimental study of peculiarities and mechanism of neuroprotective action of mexidol in hemorrhagic stroke].
An efficacy of mexidol, a Russian drug of the new generation, used in 100 mkg during 7 days has been demonstrated in rats in the model of experimentally caused intracerebral posttraumatic hematoma (hemorrhagic stroke). The drug significantly reduced the number of neurological impairments (paresis, riding-arena movements) and increased the animal's survival rate. Mexidol improved learning and memory in rats with hemorrhagic stroke in the passive avoidance test and exerted influence on the locomotor activity in the open field test.
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D000818:Animals; D001930:Brain Injuries / Q000150:complications; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007858:Learning / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D010847:Picolines / Q000008:administration & dosage*; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D051381:Rats; D016896:Treatment Outcome
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate