title: Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects.
abstract: Carbon nanotubes (CNTs) have been used in various fields as composites with other substances or alone to develop highly functional materials. CNTs hold great interest with respect to biomaterials, particularly those to be positioned in contact with bone such as prostheses for arthroplasty, plates or screws for fracture fixation, drug delivery systems, and scaffolding for bone regeneration. Accordingly, bone-tissue compatibility of CNTs and CNT influence on bone formation are important issues, but the effects of CNTs on bone have not been delineated. Here, it is found that multi-walled CNTs adjoining bone induce little local inflammatory reaction, show high bone-tissue compatibility, permit bone repair, become integrated into new bone, and accelerate bone formation stimulated by recombinant human bone morphogenetic protein-2 (rhBMP-2). This study provides an initial investigational basis for CNTs in biomaterials that are used adjacent to bone, including uses to promote bone regeneration. These findings should encourage development of clinical treatment modalities involving CNTs.
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390-8621, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Usui
authors.forename: Kaoru
authors.initials: K
authors.lastname: Aoki
authors.forename: Nobuyo
authors.initials: N
authors.lastname: Narita
authors.forename: Narumichi
authors.initials: N
authors.lastname: Murakami
authors.forename: Isao
authors.initials: I
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Norio
authors.initials: N
authors.lastname: Ishigaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Seiichi
authors.initials: S
authors.lastname: Taruta
authors.forename: Yoong Ahm
authors.initials: YA
authors.lastname: Kim
authors.forename: Morinobu
authors.initials: M
authors.lastname: Endo
authors.forename: Naoto
authors.initials: N
authors.lastname: Saito
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D017886:Durapatite; D006108:Graphite; D006801:Humans; D008297:Male; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000633:toxicity / Q000648:ultrastructure; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D019736:Prostheses and Implants; D011994:Recombinant Proteins / Q000494:pharmacology; D013499:Surface Properties; D016212:Transforming Growth Factor beta / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: C525718:BMP2 protein, human; D001672:Biocompatible Materials; C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D037742:Nanotubes, Carbon; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D006108:Graphite; D017886:Durapatite