title: [(Over-)flowing bone: the rare disease of melorheostosis: clinical presentation and therapeutic concepts demonstrated by three cases].
abstract: Melorheostosis is a rare, benign, and sporadically occurring osteosclerosis of unknown cause. The onset of the disease is usually in early adulthood. Melorheostosis affects both genders, develops progressively, and is usually limited to one side of the human body. The sclerosis originates predominantly from the cortices of the long bones of the lower limbs and rarely the upper limbs. Frequently, the sclerosis involves the soft tissue surrounding the affected bones which may cause limitations in the range of motion, contractures, deformities, and pain. Melorheostosis is usually diagnosed by radiograms. Pain relief and restoration of the full range of motion are the primary goals of the therapeutic approach. A good outcome cannot always be achieved and a recurrence of the disease happens very often.
authors.affiliation: Department of Orthopaedics and Cell Biology, Yale University School of Medicine, 333 Cedar Street, SHM-IE 55, P.O. Box 208044, New Haven, CT 06520-8044, USA. eric.hesse@yale.edu
authors.forename: E
authors.initials: E
authors.lastname: Hesse
authors.forename: J
authors.initials: J
authors.lastname: Brand
authors.forename: L
authors.initials: L
authors.lastname: Bastian
authors.forename: C
authors.initials: C
authors.lastname: Krettek
authors.forename: R
authors.initials: R
authors.lastname: Meller
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000209:etiology* / Q000601:surgery*; D008557:Melorheostosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D008875:Middle Aged; D011859:Radiography; D016896:Treatment Outcome