Chimerism and tolerance in a recipient of a deceased-donor liver transplant.
Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.
Alexander
Stephen I
SI
Centre for Kidney Research, Children's Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney, Sydney, Australia.
Smith
Neil
N
Hu
Min
M
Verran
Deborah
D
Shun
Albert
A
Dorney
Stuart
S
Smith
Arabella
A
Webster
Boyd
B
Shaw
Peter John
PJ
Lammi
Ahti
A
Stormon
Michael O
MO
D002648:Child; D005260:Female; D006086:Graft vs Host Disease; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D017114:Liver Failure, Acute / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D018183:Transplantation Chimera / Q000276:immunology*; D023001:Transplantation Tolerance / Q000235:genetics / Q000276:immunology*; D014184:Transplantation, Homologous