Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks.
OBJECTIVE
To evaluate the duration of the effect of mepivacaine when hyaluronidase is injected immediately prior to the end of pulpal anesthesia.


METHODS
Forty bilateral, symmetrical third molar surgeries were performed in 20 healthy patients. Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine. Hyaluronidase (75 turbidity-reducing units) or a placebo was injected 40 minutes after the beginning of pulpar anesthesia (randomized and double-blind trial). The duration of effect in the pulpal and gingival tissues was evaluated by response to painful electrical stimuli applied to the adjacent premolar, and by mechanical stimuli (pin prick) to the vestibular gingiva, respectively.


RESULTS
In both tissues, the duration of anesthetic effect with hyaluronidase was longer (P < .01) than with the placebo.


CONCLUSIONS
Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks.
Tempestini Horliana
Anna Carolina Ratto
AC
Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil. acrth@usp.br
de Brito
Mayara Aguilar Dias
MA
Perez
Flávio Eduardo Guillin
FE
Simonetti
Maria Prazeres Barbalho
MP
Rocha
Rodney Garcia
RG
Borsatti
Maria Aparecida
MA
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local; D003782:Dental Pulp / Q000187:drug effects; D003791:Dental Pulp Test / Q000379:methods; D004357:Drug Synergism; D004812:Epidemiologic Methods; D004837:Epinephrine; D005260:Female; D005881:Gingiva / Q000187:drug effects; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D008297:Male; D008340:Mandibular Nerve / Q000187:drug effects*; D008619:Mepivacaine; D008964:Molar, Third / Q000601:surgery; D009407:Nerve Block / Q000379:methods*; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D000779:Anesthetics, Local; D008619:Mepivacaine; D006821:Hyaluronoglucosaminidase; D004837:Epinephrine