[Effect of cimetidine on E-selectin expression on the vascular endothelium stimulated by anti-cancer drug].
Various anticancer drug treatments have contributed to elongating survival of cancer patients. However, cancer often metastasizes and recurs in spite of anti-cancer drug treatment. It is important to control metastasis in order to achieve a favorable outcome. In this study, we confirmed that an expression of E-selectin in human umbilical vein endothelial cells (HUVEC) was stimulated by 5-FU, and that the expression of E-selectin was inhibited by cimetidine which was a H2 receptor antagonist.
Kawase
Jin
J
Department of Surgery, Banbuntan Houtokukai Hospital, Fujita Health University.
Kobayashi
Kenichi
K
Imaeda
Yoshihiro
Y
Umemoto
Syunji
S
Ozawa
Souji
S
Matsumoto
Sumio
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002927:Cimetidine / Q000494:pharmacology*; D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans
D000970:Antineoplastic Agents; D019040:E-Selectin; D002927:Cimetidine