Flux change in basophil membrane is not the main pathogenesis for hypersensitivity.
The oxidation process is one of the most important natural processes. Oxidative change in hypersensitivity is believed to be an important process in the pathogenesis. However, the clear explanation on the transmembrane flux change ofbasophil and its correlation to hypersensitivity pathogenesis has never been reported. Here, the author determines the transmembrane oxidation flux in basophil. The simulation test to determine the oxidation flux change based on nanomedicine technique is used. Of interest, no change of flux can be detected. Therefore, this work can support the finding that the oxidation flux change is not an important part in the pathogenesis of basophil-related hypersensitivity.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@yahoo.com
D000818:Animals; D001491:Basophils / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen