Calcium and cell death.
Calcium signalling system controls majority of cellular reactions. Calcium signals occurring within tightly regulated temporal and spatial domains, govern a host of Ca2(+)-dependent enzymes, which in turn determine specified cellular responses. Generation of Ca2+ signals is achieved through coordinated activity of several families of Ca2+ channels and transporters differentially distributed between intracellular compartments. Cell damage induced by environmental insults or by overstimulation of physiological pathways results in pathological Ca2+ signals, which trigger necrotic or apoptotic cellular death.
Verkhratsky
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Faculty of Life Sciences, The University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK. alex.verkhratsky@manchester.ac.uk
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D019703:Calcineurin / Q000502:physiology; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D002154:Calpain / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D004720:Endonucleases / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009336:Necrosis / Q000503:physiopathology; D019001:Nitric Oxide Synthase / Q000502:physiology; D011503:Transglutaminases / Q000502:physiology; D010738:Type C Phospholipases / Q000502:physiology
D015220:Calcium Channels; D019001:Nitric Oxide Synthase; D011503:Transglutaminases; D004720:Endonucleases; D019703:Calcineurin; D010738:Type C Phospholipases; D002154:Calpain; D002118:Calcium