title: Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate potential changes that are independent of body size in the lipogenic adipokine acylation-stimulating protein (ASP), complement C3 (ASP precursor), and C-reactive protein (CRP) in subjects with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Endocrine clinic in China.
  
  
  METHODS
  Thirty-four women with PCOS and 41 age- and body mass index (BMI)-matched controls were recruited.
  
  
  METHODS
  Fasting blood samples were collected.
  
  
  METHODS
  Plasma glucose, insulin, lipids, ASP, C3, CRP, and homeostasis model assessment of insulin resistance were measured.
  
  
  RESULTS
  Plasma ASP, CRP, insulin, cholesterol, and nonesterified fatty acids were increased significantly in women with PCOS compared with in controls. Although each of these parameters also was statistically significantly correlated directly with BMI, the association with PCOS status was independent of BMI, with increased plasma values at all levels of BMI. In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ASP regardless of BMI.
  
  
  CONCLUSIONS
  Levels of ASP, CRP, and lipids are increased in subjects with PCOS, regardless of the level of BMI. The increased ASP level in both PCOS groups suggests that the ASP metabolism may be altered.
authors.affiliation: Department of Endocrinology, Tongji Hospital, Hua Zhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Wu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wen
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Muxun
authors.initials: M
authors.lastname: Zhang
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D003176:Complement C3 / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008597:Menstrual Cycle; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D003176:Complement C3; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D002097:C-Reactive Protein