Wnt/Notch signalling and information processing during development.
The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch ('Wntch') signalling act as components of an integrated device that, rather than defining the fate of a cell, determines the probability that a cell will adopt that fate.
Hayward
Penelope
P
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
Kalmar
Tibor
T
Arias
Alfonso Martinez
AM
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D047108:Embryonic Development / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D051880:Receptors, Notch; D051153:Wnt Proteins