Rift Valley fever outbreak with East-Central African virus lineage in Mauritania, 2003.
In October 2003, 9 human cases of hemorrhagic fever were reported in 3 provinces of Mauritania, West Africa. Test results showed acute Rift Valley fever virus (RVFV) infection, and a field investigation found recent circulation of RVFV with a prevalence rate of 25.5% (25/98) and 4 deaths among the 25 laboratory-confirmed case-patients. Immunoglobulin M against RVFV was found in 46% (25/54) of domestic animals. RVFV was also isolated from the mosquito species Culex poicilipes. Genetic comparison of virion segments indicated little variation among the strains isolated. However, phylogenetic studies clearly demonstrated that these strains belonged to the East-Central African lineage for all segments. To our knowledge, this is the first time viruses of this lineage have been observed in an outbreak in West Africa. Whether these strains were introduced or are endemic in West Africa remains to be determined.
Faye
Ousmane
O
Institut Pasteur de Dakar, Dakar, Sénégal.
Diallo
Mawlouth
M
Diop
Djibril
D
Bezeid
O Elmamy
OE
Bâ
Hampathé
H
Niang
Mbayame
M
Dia
Ibrahima
I
Mohamed
Sid Ahmed Ould
SA
Ndiaye
Kader
K
Diallo
Diawo
D
Ly
Peinda Ogo
PO
Diallo
Boubacar
B
Nabeth
Pierre
P
Simon
François
F
Lô
Baïdy
B
Diop
Ousmane Madiagne
OM
D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003465:Culex / Q000821:virology*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D014644:Genetic Variation; D006041:Goats; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007303:Insect Vectors / Q000821:virology*; D008297:Male; D008435:Mauritania / Q000453:epidemiology; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D012295:Rift Valley Fever / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission / Q000821:virology; D012296:Rift Valley fever virus / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D016036:Seroepidemiologic Studies; D012756:Sheep; D015047:Zoonoses
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D012367:RNA, Viral