Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats.
We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-gamma), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-gamma, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-gamma, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes.
Hunter
Randy L
RL
Department of Anatomy and Neurobiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA.
Choi
Dong-Young
DY
Ross
Stuart A
SA
Bing
Guoying
G
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007473:Ion Channels / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D000077205:Pioglitazone; D051381:Rats; D017207:Rats, Sprague-Dawley; D045162:Thiazolidinediones / Q000494:pharmacology*; D000071246:Uncoupling Protein 2
D007004:Hypoglycemic Agents; D007473:Ion Channels; D008070:Lipopolysaccharides; D024101:Mitochondrial Proteins; D047495:PPAR gamma; D045162:Thiazolidinediones; C000604391:Ucp2 protein, rat; D000071246:Uncoupling Protein 2; C481940:mitochondrial protein 17 kDa, rat; D000077205:Pioglitazone