Aspirin-associated intracerebral hemorrhage in a patient with CADASIL.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease characterized by ischemic stroke, cognitive impairment, migraine and neuropsychological deficit. Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown. We present a 39-year-old man with CADASIL who had two years history of untreated hypertension. In this patient, acute ICH developed only two weeks after the initiation of aspirin. Brain images demonstrated a 3cmx3cm hyperacute ICH in the left temporal lobe at the site of previous old hemorrhage. The presence of cerebral microbleed and use of antithrombotics may be associated with development of ICH in patients with CADASIL.
Oh
Jung-Hwan
JH
Department of Neurology, Cheju National University School of Medicine, Jeju, Republic of Korea.
Lee
Jung Seok
JS
Kang
Sa-Yoon
SY
Kang
Ji-Hoon
JH
Choi
Jay Chol
JC
D000208:Acute Disease; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D046589:CADASIL / Q000150:complications* / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D038524:Diffusion Magnetic Resonance Imaging; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control; D013702:Temporal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin