Implications of activity-dependent neurotransmitter-receptor matching.
Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.
Spitzer
Nicholas C
NC
Neurobiology Section, Division of Biological Sciences, Center for Molecular Genetics, Kavli Institute for Brain and Mind, UCSD, La Jolla, CA 92093, USA. nspitzer@ucsd.edu
Borodinsky
Laura N
LN
D000818:Animals; D054792:Muscle, Striated / Q000378:metabolism; D009420:Nervous System / Q000196:embryology*; D009469:Neuromuscular Junction / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter