Non-coding RNAs regulating the transcriptional machinery.
During the past decade, numerous ncRNAs (non-coding RNAs) have been identified as regulators of transcription. This review focuses on a few examples of ncRNAs that directly interact with and regulate components of the transcription machinery. Artificial RNA aptamers have been selected against components of the transcriptional machinery. The bacterial 6S RNA and the eukaryotic B2 RNA directly target RNA polymerases. The 7SK RNA, U1 snRNA (small nuclear RNA) and SRA (steroid receptor RNA activator) RNA bind to and regulate the activity of transcription factors. Xist (X-inactive-specific transcript) and roX (RNA on the X) RNAs are involved in epigenetic regulation of transcription through the recruitment of histone-modifying enzymes.
Barrandon
Charlotte
C
CNRS UMR 8541, Ecole Normale Supérieure, 46 rue d'Ulm, Paris, Cedex 05, France.
Spiluttini
Béatrice
B
Bensaude
Olivier
O
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D022661:RNA, Untranslated / Q000378:metabolism*; D013698:Templates, Genetic; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D022661:RNA, Untranslated; D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases