[Impact of growth hormone with hypocaloric nutrition on nitrogen balance and blood glucose in patients after gastrointestinal operation].
OBJECTIVE
To evaluate the impact of recombinant human growth hormone (rhGH) combined with hypocaloric nutrition on nitrogen balance and blood glucose in patients after gastrointestinal operation.


METHODS
Forty-eight patients undergone abdominal operations were randomly divided into either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) injection daily for 7 days postoperatively. These two groups had similar nutritional intakes. Body weight, blood cell count, liver and renal function, plasma albumin, prealbumin, transferrin and fibronectin were measured at day 1 before operation as baseline and day 3 and day 10 after operation by standard laboratory techniques. Nitrogen balance and blood glucose were measured from day 3 to day 9 after operation.


RESULTS
At postoperative day 10, the cumulative nitrogen balance and the level of plasma fibronectin were significantly higher in rhGH group [13.21 g,(104.77+/-19.94) mg/L] than those in placebo group [-6.88 g, (93.03+/-16.03) mg/L] (P<0.05). Furthermore, at day 4 and from day 6 to day 9 after operation, daily nitrogen balance was higher in rhGH group than that in control group (P<0.05). Mean blood glucose level was significantly higher in rhGH group from day 3 to day 6 after operation [(7.68+/-2.15) vs (5.95+/-2.34) mmol/L, P<0.05]. But hyperglycemia could be controlled well by insulin treatment.


CONCLUSIONS
Growth hormone combined with hypocaloric nutrition is effective and safe in promoting positive nitrogen balance and protein synthesis in post-operative patients, which is also beneficial to the improvement of nutritional status and prognosis.
Zhang
Ming-ming
MM
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zheng
Ya-min
YM
He
Tao
T
Zhou
Yong
Y
Qian
Kun
K
Wu
Xiao-ting
XT
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D031204:Caloric Restriction; D013505:Digestive System Surgical Procedures; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D018529:Nutritional Support / Q000379:methods*; D011184:Postoperative Period; D011994:Recombinant Proteins / Q000627:therapeutic use*
D001786:Blood Glucose; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D009584:Nitrogen