title: Homing of radiolabelled recombinant interleukin-2 activated natural killer cells and their efficacy in adoptive immunotherapy against murine fibrosarcoma.
abstract: Natural killer (NK) cells are spontaneously cytotoxic against tumour target cells. Their number was found to be four times more in the spleen of tumour-bearing Swiss albino mice. After activation with recombinant interleukin-2 (rIL-2), NK cells were tested and found to seek out the tumour site when injected intravenously in tumour-bearing mice. Their potential for fighting tumours in vivo was further seen following adoptive transfer of rIL-2 activated NK (A-NK) cells in tumour-bearing mice. After surgical removal of tumour load, adoptive transfer of A-NK cells inhibited tumour recurrence in 92.3%cases, thereby suggesting the use of this protocol for therapeutic purposes to obtain a better outcome.
authors.affiliation: Department of Zoology, St Joseph's College, Darjeeling 734 104, India. anuradharai62@yahoo.com
authors.forename: Anuradha
authors.initials: A
authors.lastname: Rai
authors.forename: Ashim K
authors.initials: AK
authors.lastname: Chakravarty
mesh_terms: D000818:Animals; D005354:Fibrosarcoma / Q000276:immunology* / Q000628:therapy*; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D055502:Secondary Prevention; D013997:Time Factors
chemical_list: D007376:Interleukin-2