title: Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease.
abstract: OBJECTIVE
  Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor.
  
  
  METHODS
  For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters.
  
  
  RESULTS
  A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin.
  
  
  CONCLUSIONS
  This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.
authors.affiliation: Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
authors.forename: Daryoush Hamidi
authors.initials: DH
authors.lastname: Alamdari
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Parizadeh
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ghafoori
authors.forename: Seyyed Mohammad Reza
authors.initials: SM
authors.lastname: Kazemi-Bajestani
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Paletas
authors.forename: Theodosia
authors.initials: T
authors.lastname: Pegiou
authors.forename: George
authors.initials: G
authors.lastname: Koliakos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species