Pyoderma gangrenosum--rebel without a cure?
BACKGROUND
Pyoderma gangrenosum (PG) is a rare neutrophilic, ulcerating dermatosis that is frequently difficult to diagnose and often a diagnosis of exclusion. It is hypothesized that PG may be caused by an abnormal T-cell and neutrophil response, which correlates with its common link to other disorders, such as inflammatory bowel disease, rheumatoid arthritis, and malignancies. Several treatments have been used successfully for PG, but none has proven to be universally effective.


METHODS
We present three cases of PG treated with adalimumab after failed courses of steroids (orally and parenterally), thalidomide, cyclosporine, and mycophenolate mofetil.


RESULTS
Patients 2 and 3, who had previously responded to infliximab, albeit with recurrence, were successfully treated with adalimumab at a dose of 40 mg once a week. Patient 1 initially responded to adalimumab, but after 7.5 months failed to show wound bed improvement at a dose of 80 mg/week subcutaneously. This patient had not previously been treated with infliximab.


CONCLUSIONS
We believe adalimumab to be a valuable alternative for the treatment of PG, with comparable efficacy to infliximab.
Jacob
Sharon E
SE
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, and Florida Academic Dermatology Center, Miami, Florida, USA.
Weisman
Robyn S
RS
Kerdel
Francisco A
FA
D000068879:Adalimumab; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D016572:Cyclosporine / Q000009:adverse effects; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*; D012008:Recurrence; D013792:Thalidomide / Q000009:adverse effects; D017211:Treatment Failure
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D013792:Thalidomide; D016572:Cyclosporine; D000069285:Infliximab; D000068879:Adalimumab; D009173:Mycophenolic Acid