title: Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.
abstract: A new polybrominated diphenyl ether ( 9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.
authors.affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, 1039 University Drive, Duluth, Minnesota 55812,USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Andrew
authors.initials: A
authors.lastname: Skildum
authors.forename: Emily
authors.initials: E
authors.lastname: Stromquist
authors.forename: Teresa
authors.initials: T
authors.lastname: Rose-Hellekant
authors.forename: Leng Chee
authors.initials: LC
authors.lastname: Chang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D047088:Dysidea / Q000737:chemistry*; D005260:Female; D006801:Humans; D025301:Hyphae / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011075:Polybrominated Biphenyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects
chemical_list: C528140:3,4,5-tribromo-6-methoxy-2-(2',4'-dibromophenoxy)phenol; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls