title: Control of transcription in Schistosoma mansoni: chromatin remodeling and other regulatory elements.
abstract: The platyhelminth parasite Schistosoma mansoni, the causative agent of schistosomiasis, is a dioecious parasite with a complex life cycle that includes two different hosts and two free-living stages. Yet very little is known about the biochemical details connected to these different transitions. In the present work, results will be presented showing the most recent results in S. mansoni regarding the characterization of transcription factors and coactivators that act directly on the transcriptional machinery and those that are involved with chromatin remodeling. It is hoped that the information gathered here may contribute towards the understanding of crucial events in the parasite life cycle. Likewise, the development of new drugs that could interfere with oogenesis and sexual maturation may eventually profit from the information contained herein.
authors.affiliation: Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Cidade Universitária, CEP 21941-590, Rio de Janeiro, Brazil.
authors.forename: Marcelo Rosado
authors.initials: MR
authors.lastname: Fantappíé
authors.forename: Francisco M Bastos
authors.initials: FM
authors.lastname: de Oliveira
authors.forename: Renata
authors.initials: R
authors.lastname: de Moraes Maciel dos Santos
authors.forename: José João
authors.initials: JJ
authors.lastname: Mansure
authors.forename: Daniel Rodrigues
authors.initials: DR
authors.lastname: Furtado
authors.forename: Isabel Caetano
authors.initials: IC
authors.lastname: de Abreu da Silva
authors.forename: Franklin David
authors.initials: FD
authors.lastname: Rumjanek
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D050436:Regulatory Elements, Transcriptional; D012550:Schistosoma mansoni / Q000502:physiology*