title: Updating the ICRP human respiratory tract model.
abstract: The ICRP Task Group on Internal Dosimetry is developing new Occupational Intakes of Radionuclides (OIR) documents. Application of the Human Respiratory Tract Model (HRTM) requires a review of the lung-to-blood absorption characteristics of inhaled compounds of importance in radiological protection. Where appropriate, material-specific absorption parameter values will be given, and for other compounds, assignments to default Types will be made on current information. Publication of the OIR provides an opportunity for updating the HRTM in the light of experience and new information. The main possibilities under consideration relate to the two main clearance pathways. Recent studies provide important new data on rates of particle transport from the nasal passages, bronchial tree (slow phase) and alveolar region. The review of absorption rates provides a database of parameter values from which consideration can be given to deriving typical values for default Types F, M and S materials, and element-specific rapid dissolution rates.
authors.affiliation: Radiation Protection Division, Health Protection Agency, Chilton, Oxon OX11 0RQ, UK. mike.bailey@hpa.org.uk
authors.forename: M R
authors.initials: MR
authors.lastname: Bailey
authors.forename: E
authors.initials: E
authors.lastname: Ansoborlo
authors.forename: R A
authors.initials: RA
authors.lastname: Guilmette
authors.forename: F
authors.initials: F
authors.lastname: Paquet
mesh_terms: D000336:Aerosols / Q000032:analysis / Q000493:pharmacokinetics*; D003198:Computer Simulation; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D038622:Internationality; D008168:Lung / Q000378:metabolism*; D008954:Models, Biological; D009928:Organ Specificity; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011886:Radon / Q000032:analysis* / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012958:Societies, Scientific
chemical_list: D000336:Aerosols; D011886:Radon