title: Smoking during pregnancy and offspring externalizing problems: an exploration of genetic and environmental confounds.
abstract: Previous studies have documented that smoking during pregnancy (SDP) is associated with offspring externalizing problems, even when measured covariates were used to control for possible confounds. However, the association may be because of nonmeasured environmental and genetic factors that increase risk for offspring externalizing problems. The current project used the National Longitudinal Survey of Youth and their children, ages 4-10 years, to explore the relations between SDP and offspring conduct problems (CPs), oppositional defiant problems (ODPs), and attention-deficit/hyperactivity problems (ADHPs) using methodological and statistical controls for confounds. When offspring were compared to their own siblings who differed in their exposure to prenatal nicotine, there was no effect of SDP on offspring CP and ODP. This suggests that SDP does not have a causal effect on offspring CP and ODP. There was a small association between SDP and ADHP, consistent with a causal effect of SDP, but the magnitude of the association was greatly reduced by methodological and statistical controls. Genetically informed analyses suggest that unmeasured environmental variables influencing both SDP and offspring externalizing behaviors account for the previously observed associations. That is, the current analyses imply that important unidentified environmental factors account for the association between SDP and offspring externalizing problems, not teratogenic effects of SDP.
authors.affiliation: Indiana University, Bloomington, IN 47405, USA. bmdonofr@indiana.edu
authors.forename: Brian M
authors.initials: BM
authors.lastname: D'Onofrio
authors.forename: Carol A
authors.initials: CA
authors.lastname: Van Hulle
authors.forename: Irwin D
authors.initials: ID
authors.lastname: Waldman
authors.forename: Joseph Lee
authors.initials: JL
authors.lastname: Rodgers
authors.forename: K Paige
authors.initials: KP
authors.lastname: Harden
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rathouz
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Lahey
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D015984:Causality; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D019955:Conduct Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D004200:Diseases in Twins / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007389:Internal-External Control; D007604:Juvenile Delinquency / Q000523:psychology / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D035781:Siblings; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D012931:Social Environment; D014481:United States