title: Substantia nigra MR imaging signal changes and cardiomyopathy following prenatal exposure to cocaine and heroin.
abstract: Exposure to cocaine in utero results in behavioral and neurodevelopmental abnormalities that persist into adulthood. Conventional MR imaging has generally failed to reveal the expected structural lesions to explain these clinical findings. We report a case of focal MR imaging signal-intensity changes in the substantia nigra, locus ceruleus, and other selected nerve tracts and nuclei in a child exposed prenatally to cocaine and other drugs. The patient also had dilated cardiomyopathy.
authors.affiliation: Department of Diagnostic Radiology, Northeastern Ohio Universities College of Medicine-Canton Affiliated Hospitals, Canton, Ohio 44710, USA. ryanradiology@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.forename: B
authors.initials: B
authors.lastname: McNulty
authors.forename: G
authors.initials: G
authors.lastname: Gaisie
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000175:diagnosis*; D002657:Child Development / Q000187:drug effects; D003042:Cocaine / Q000009:adverse effects*; D005183:Failure to Thrive / Q000139:chemically induced / Q000209:etiology; D005260:Female; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009294:Narcotics / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000209:etiology; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology*
chemical_list: D009294:Narcotics; D003932:Heroin; D003042:Cocaine