[Effect of proteins from the Agkistrodon blomhoffii ussuriensis snake venom on platelets in the hemostasis system].
Influence of proteins from the Agkistrodon blomhoffii ussuriensis snake venom on platelet activation and aggregation was developed on different model systems in vitro. It was shown that novel disintegrin (Blomus-B) and phospholipase A2 (Blopholipase) from the venom, activated platelets and inhibited their aggregation. Fibrino(geno)lityc enzyme (Blomulyse) does not activate platelets and has no effect on their aggregation stimulated by collagen, but inhibit ADP and adrenalin-stimulated platelet aggregation. Thrombin-like enzyme (Ancistron-Bu) activates platelets but has no effect on their aggregation. Obtained proteins can be used under development of new antiplatelet agents and as instruments for detailed elaboration and deep investigation of processes which proceed with participation of platelets.
Karbovs'kyĭ
V L
VL
Savchuk
O M
OM
Volkov
H L
HL
Zaichko
N V
NV
Bukhan
Ts
Ts
D017836:Agkistrodon; D000818:Animals; D003435:Crotalid Venoms / Q000737:chemistry*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology
C031442:Agkistrodon venoms; D003435:Crotalid Venoms; D010975:Platelet Aggregation Inhibitors; D011506:Proteins