Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection.
The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1(+) monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicate the importance of neutrophils during infection. Yet, in recent years it has become clear that additional cell types express the Gr-1 determinant, including dendritic cell and monocyte subpopulations. In this review, we evaluate current knowledge on the functional aspects of Gr-1(+) cell populations. We focus on infection with the opportunistic protozoan Toxoplasma gondii, a case where host survival depends on an intact Gr-1(+) cell population.
Egan
Charlotte E
CE
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Sukhumavasi
Woraporn
W
Bierly
Allison L
AL
Denkers
Eric Y
EY
D000818:Animals; D003141:Communicable Diseases / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D054390:Receptors, CCR2 / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology
C515335:Ccr2 protein, mouse; C503133:Gr-1 protein, mouse; D054390:Receptors, CCR2; D019707:Receptors, Chemokine