title: Hepatocellular carcinoma presenting as a precocious cutaneous metastasis.
abstract: The authors report a case of hepatocellular carcinoma (HCC) diagnosed by evaluation of a cutaneous metastasis in a patient without a prior diagnosis of HCC. Subsequent evaluation confirmed the presence of additional widespread metastatic disease. The medical literature is reviewed with regards to cutaneous metastasis, including precocious metastasis, of HCC. The pathologic evaluation of HCC is reviewed, including a discussion of the immunohistochemical profile of this malignancy and the utility of hepatocyte paraffin 1, CD10, and polyclonal carcinoembryonic antigen (pCEA) immunohistochemical stains.
authors.affiliation: Department of Pathology and Area Laboratory Services, Walter Reed Army Medical Center, Washington, DC 20307, USA. michael.royer1@us.army.mil
authors.forename: Michael C
authors.initials: MC
authors.lastname: Royer
authors.forename: Walter L
authors.initials: WL
authors.lastname: Rush
authors.forename: George P
authors.initials: GP
authors.lastname: Lupton
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000556:secondary*
chemical_list: D014408:Biomarkers, Tumor