title: Anti-allergic prenylated flavonoids from the roots of Sophora flavescens.
abstract: The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.
authors.affiliation: Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
authors.forename: Wenying
authors.initials: W
authors.lastname: Quan
authors.forename: Hee Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Chul Young
authors.initials: CY
authors.lastname: Kim
authors.forename: Chu Won
authors.initials: CW
authors.lastname: Noh
authors.forename: Byung Hun
authors.initials: BH
authors.lastname: Um
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Oak
authors.forename: Kyeong-Man
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D015471:Leukemia, Basophilic, Acute; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D029909:Sophora / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D005419:Flavonoids; D001619:beta-N-Acetylhexosaminidases