title: [Chronic Chagas disease patients with sinus node dysfunction: is the presence of IgG antibodies with muscarinic agonist action independent of left ventricular dysfunction?].
abstract: Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.
authors.affiliation: Serviço de Cardiologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ. mba@hucff.ufrj.br
authors.forename: Maria Beatriz Corrêa de Mello
authors.initials: MB
authors.lastname: Altschüller
authors.forename: Roberto Coury
authors.initials: RC
authors.lastname: Pedrosa
authors.forename: Basílio de Bragança
authors.initials: Bde B
authors.lastname: Pereira
authors.forename: Wilson Braz
authors.initials: WB
authors.lastname: Corrêa Filho
authors.forename: Aline Silva de
authors.initials: AS
authors.lastname: Medeiros
authors.forename: Patrícia Cristina Santos
authors.initials: PC
authors.lastname: Costa
authors.forename: Antonio Carlos Campos
authors.initials: AC
authors.lastname: de Carvalho
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D002598:Chagas Cardiomyopathy / Q000276:immunology* / Q000503:physiopathology; D002908:Chronic Disease; D004562:Electrocardiography; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000378:metabolism; D016014:Linear Models; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000097:blood* / Q000378:metabolism; D043585:Receptor, Muscarinic M2 / Q000819:agonists / Q000097:blood*; D012849:Sinoatrial Node / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D018721:Muscarinic Agonists; D043585:Receptor, Muscarinic M2