title: Cannabinoids for cancer treatment: progress and promise.
abstract: Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work that raises interest in the development and exploration of potent, nontoxic, and nonhabit forming cannabinoids for cancer therapy.
authors.affiliation: Chemoprevention Program, Paul P. Carbone Comprehensive Cancer Center and Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Sami
authors.initials: S
authors.lastname: Sarfaraz
authors.forename: Vaqar M
authors.initials: VM
authors.lastname: Adhami
authors.forename: Deeba N
authors.initials: DN
authors.lastname: Syed
authors.forename: Farrukh
authors.initials: F
authors.lastname: Afaq
authors.forename: Hasan
authors.initials: H
authors.lastname: Mukhtar
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy; D002186:Cannabinoids / Q000145:classification / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism / Q000502:physiology; D012878:Skin Neoplasms / Q000188:drug therapy
chemical_list: D002186:Cannabinoids; D043882:Receptors, Cannabinoid