Functional correlates of incoordination in patients with spinocerebellar ataxia 1: a preliminary fMRI study.
The neural (blood oxygenation level dependent) correlates of motor coordination of both hands were studied in adult right-handed volunteers and patients with spinocerebellar ataxia 1 (SCA1), using functional magnetic resonance imaging (fMRI) of the entire brain. Each experimental condition consisted of five sets of alternate pronation and supination tasks for either hand in a prescribed sequence as the active phase followed by a period of rest. An intricate network consisting of sensorimotor cortex, supplementary motor area (SMA), cingulate motor area (CMA), putamina and cerebellum, was identified when the task was performed in healthy volunteers. However, cerebellar activity was largely absent with additional activity in contralateral cortices and in thalami in patients with SCA1. This apparent decoupling of sensorimotor cortical and cerebellar areas during coordinated movement in patients with SCA1, suggests that cortico-cerebellar loops may be malfunctioning in SCA1.
Jayakumar
Peruvumba Narayan
PN
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India. jayakumarpn@nimhans.kar.nic.in
Desai
Sunali
S
Pal
Pramod Kumar
PK
Balivada
Sudha
S
Ellika
Shehanaz
S
Kalladka
Dheeraj
D
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000209:etiology* / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D020754:Spinocerebellar Ataxias / Q000150:complications* / Q000473:pathology; D013647:Task Performance and Analysis
D010100:Oxygen