Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial.
Retaining high-risk individuals is critical for HIV prevention trials. The current analyses examined predictors of trial dropout among HIV-infected men and women in a multi-site HIV prevention trial. Results indicated that dropouts (n = 74) were more likely to be younger, depressed, and not taking antiretroviral therapy (ART) than those who continued (n = 815). No other background, substance use, or transmission risk differences were found, suggesting no direct evidence of dropout bias on key outcomes. Efforts may be warranted for early detection and treatment of depression and for improving retention of younger participants and those not on ART.
Johnson
Mallory O
MO
University of California, 50 Beale Street, San Francisco, CA 94105, USA. Mallory.Johnson@ucsf.edu
Dilworth
Samantha E
SE
Neilands
Torsten B
TB
Chesney
Margaret A
MA
Rotheram-Borus
Mary Jane
MJ
Remien
Robert H
RH
Weinhardt
Lance
L
Ehrhardt
Anke A
AA
Morin
Stephen F
SF
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003863:Depression; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000635:transmission; D015497:HIV-1; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D010352:Patient Dropouts / Q000523:psychology / Q000706:statistics & numerical data; D010358:Patient Participation / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D012306:Risk
D019380:Anti-HIV Agents