[Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock].
OBJECTIVE
To investigate the effect of ethyl pyruvate (EP) on indices of tissue oxygenation and perfusion in dogs with septic shock.


METHODS
Twenty dogs with septic shock induced by lipopolysaccharides (LPS) were randomly divided into two groups. Dog randomly received placebo (Ringer's solution; control group, n =8) or EP in lactated Ringer's solution (0.05 g/kg loading dose over 10 minutes, thereafter 0.05 g.kg(-1).h(-1) for 12 hours; EP treatment group, n =12). Indices of tissue oxygenation and perfusion were monitored every 2 hours after basic measurements (pre-LPS), including oxygen delivery (DO2), oxygen consumption (VO2), serum levels of lactate (Lac), mixed venous oxygen saturation (SvO2), urine output, intramucosal pH (pHi), gastric-to-arteria partial pressure of carbon dioxide gap (Pg-a CO2).


RESULTS
DO2, VO2, SvO2 and urine output dropped significantly after septic shock (all P<0.05), but serum levels of Lac and P g-a CO2 elevated markedly (both P<0.05). DO2 increased gradually in EP group and there were significantly differences compared with control group after 8 hours (P<0.05). VO2 showed such a tendency, but there was no statistically significant intergroup difference (P>0.05). SvO2 elevated gradually in EP group, even higher than those of pre-LPS after 10 hours and there were significantly differences compared with control group (P<0.05). Serum levels of Lac decreased gradually and there was significant difference compared with control group after 8 hours (P<0.05). Urine output increased in EP group after 8 hours, and such phenomenon did not happen in control group after 10 hours (P<0.05). pHi elevated to a higher level after 6 hours, and Pg-a CO2 elevated in the treatment group, and there were significantly differences compared with control group (both P<0.05).


CONCLUSIONS
EP infusion resulted in improved tissue oxygenation and perfusion in dogs with septic shock.
Kou
Qiu-ye
QY
Surgical Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Guan
Xiang-dong
XD
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D008297:Male; D010101:Oxygen Consumption; D011773:Pyruvates / Q000494:pharmacology*; D012772:Shock, Septic / Q000378:metabolism* / Q000503:physiopathology
D011773:Pyruvates; C046522:ethyl pyruvate