title: The evolution of obstruction induced overactive bladder symptoms following urethrolysis for female bladder outlet obstruction.
abstract: OBJECTIVE
  Bladder outlet obstruction following stress incontinence surgery may present as a spectrum of lower urinary tract symptoms. We evaluated the prevalence and impact of persistent overactive bladder symptoms following urethrolysis for iatrogenic bladder outlet obstruction.
  
  
  METHODS
  In a retrospective review we identified 40 patients who underwent urethrolysis. All patients underwent a standardized urological evaluation. Patients identified with genitourinary erosion, neurogenic bladder dysfunction and preexisting overactive bladder were excluded. Urethrolysis outcomes were determined by subjective bladder symptoms and objective parameters. Validated questionnaires were completed to assess symptom bother, patient satisfaction and quality of life. Statistical analyses were performed using Stata, version 9.0.
  
  
  RESULTS
  A total of 40 patients were included in the study with a mean +/- SD followup of 13 +/- 11 months (range 3 to 38). Of the patients 34 patients presented with obstructive symptoms, while 36 had overactive bladder symptoms. Obstructive symptoms resolved in 28 of the 34 patients (82%), while overactive bladder symptoms resolved completely in only 12 (35%) and they were significantly improved in 4 (12%). Overall 20 patients (56%) were on antimuscarinics for refractory overactive bladder and 8 ultimately required sacral neuromodulation. Pre-urethrolysis detrusor overactivity was more likely in patients with persistent overactive bladder symptoms than in those in whom overactive bladder symptoms resolved (70% vs 38%). Patients with persistent overactive bladder had significantly greater symptom severity/bother, and decreased perception of improvement and quality of life following urethrolysis.
  
  
  CONCLUSIONS
  Following urethrolysis overactive bladder symptoms may remain refractory in 50% or greater of patients, which has a negative impact on quality of life and the impression of improvement after surgery. Detrusor overactivity demonstrated preoperatively may be useful for predicting who may have persistent overactive bladder symptoms despite an effective urethrolysis procedure.
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2765, USA. Jonathan.s.starkman@vanderbilt.edu
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Starkman
authors.forename: John W
authors.initials: JW
authors.lastname: Duffy
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Wolter
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Kaufman
authors.forename: Harriette M
authors.initials: HM
authors.lastname: Scarpero
authors.forename: Roger R
authors.initials: RR
authors.lastname: Dmochowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014521:Urethra / Q000601:surgery; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000601:surgery*; D053201:Urinary Bladder, Overactive / Q000453:epidemiology / Q000209:etiology*; D014550:Urinary Incontinence, Stress / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000009:adverse effects*