CO and NO in medicine.
The occurrence, role and consequences of CO and NO in biological systems are reviewed. This includes their syntheses by heme oxygenases and NO synthases, their biological targets and the physiological effects of their signals. The use of CO and NO gases in medicine are discussed and methods of delivery are illustrated with particular emphasis on the therapeutic properties of compounds that generate controlled amounts of NO and CO in vivo.
Mann
Brian E
BE
Department of Chemistry, University of Sheffield, Sheffield, UK. b.mann@sheffield.ac.uk
Motterlini
Roberto
R
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D002248:Carbon Monoxide / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D006419:Heme Oxygenase (Decyclizing) / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000737:chemistry; D015398:Signal Transduction / Q000502:physiology; D013237:Stereoisomerism
D009569:Nitric Oxide; D002248:Carbon Monoxide; D019001:Nitric Oxide Synthase; D006419:Heme Oxygenase (Decyclizing)