[Subclinical Cushing's syndrome in populations at risk].
Based on autopsy studies, adrenal masses are among the most common tumors in humans. Endogenous Cushing's syndrome (CS) is unusual and adrenal adenomas account for 10% of all cases of CS. Patients with subclinical CS (SCS) present abnormal cortisol dynamics without obvious manifestations. The prevalence of hypercortisolism in clinically inapparent adrenal masses has been reported as 9%. Data from several small series of patients indicate that fewer than 20% develop hormone overproduction when followed for up to 10 years. Follow-up of patients with subclinical CS suggests that rarely masses increase in size or progress to overt CS. Adrenal incidentalomas and subclinical CS are related to metabolic disorders, in special to type-2 diabetes. The scarce available data suggest that treatment of hypercortisolism correct the metabolic abnormalities and blood pressure. Some studies evaluating the prevalence of subclinical CS in overweight type-2 diabetes patients suggest that it is considerably higher in populations at risk than in the general population.
Caetano
Maria Silvia S
MS
Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP.
Vilar
Lucio
L
Kater
Claudio E
CE
D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D018246:Adrenocortical Adenoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D006973:Hypertension / Q000175:diagnosis / Q000628:therapy; D033162:Incidental Findings; D009765:Obesity / Q000175:diagnosis; D012307:Risk Factors
D006854:Hydrocortisone