Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?
The recognition of phosphatidylserine (PS) on apoptotic cells within tissues drives both their engulfment and an accompanying anti-inflammatory and tissue restorative program. Insight into the recognition of this phospholipid signal by phagocytes is provided by papers describing three new, but completely different, PS receptors.
Bratton
Donna L
DL
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA. brattond@njc.org
Henson
Peter M
PM
D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D010586:Phagocytes / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
C524949:Adgrb1 protein, mouse; D042501:Angiogenic Proteins; D015816:Cell Adhesion Molecules, Neuronal; D008565:Membrane Proteins; D010718:Phosphatidylserines; D011956:Receptors, Cell Surface; C486733:Stab2 protein, mouse; C500399:TIM-4 protein, mouse; C408123:phosphatidylserine receptor