Amoxapine-associated acute respiratory distress.
A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground-glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions. BAL showed a predominance of neutrophils, lymphocytes and erythrocytes but not eosinophils. Amoxapine was stopped, resulting in complete resolution of the pulmonary infiltrates. When the patient was re-exposed to amoxapine (52.5 mg total dose), high fever, reduced SaO(2) and pulmonary infiltrates reappeared. We concluded that acute respiratory distress may be associated with amoxapine treatment.
Ando
Masaru
M
Division of Pulmonary Disease, Department of Brain and Nerve Science, Oita University Faculty of Medicine, Oita, Japan. mando@med.oita-u.ac.jp
Miyazaki
Eishi
E
Takenaka
Ryu-Ichi
R
Okubo
Toshiyuki
T
Matsuno
Osamu
O
Nureki
Shin-Ichi
S
Ito
Kazunobu
K
Tsuda
Tomiyasu
T
Kumamoto
Toshihide
T
D000328:Adult; D000657:Amoxapine / Q000009:adverse effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D018687:Antidepressive Agents, Second-Generation; D000657:Amoxapine