Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana.
The flavonoids kaempferol, quercetin, trifolin, hyperoside 2''- and 6''- acetates, 7-glucotrifolin, biorobin and robinin were isolated from the aerial parts of Consolida oliveriana. Their derivatives kaempferol tetraacetate, quercetin pentaacetate, trifolin heptaacetate and hyperoside octaacetate exhibited significant cytotoxicity IN VITRO against three human cell lines HL-60, U937 and SK-MEL-1 while hyperoside 2''-acetate, hyperoside-6''-acetate, glucotrifolin decaacetate and heptamethyltrifolin were inactive.
Díaz
Jesús G
JG
Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.
Carmona
Armando J
AJ
Torres
Fernando
F
Quintana
José
J
Estévez
Francisco
F
Herz
Werner
W
D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D005697:Galactosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D044949:Kaempferols / Q000494:pharmacology*; D008745:Methylation; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D029626:Ranunculaceae / Q000737:chemistry*
D005419:Flavonoids; D005697:Galactosides; D006027:Glycosides; D044949:Kaempferols; D010936:Plant Extracts; C530019:trifolin acetate