Pro-healing drug-eluting stents: a role for antioxidants?
Current strategies to lower the incidence of ISR (in-stent restenosis) following PCI (percutaneous coronary intervention) are aimed at modifying arterial healing after stent injury. This can impair endothelial recovery and render the vessel prone to acute thrombosis. As early restoration of endothelial integrity inhibits neointimal growth and thrombosis, alternative approaches which encourage this process may provide a more effective long-term result after PCI. Oxidative stress is enhanced after PCI and participates in the regulation of endothelial regeneration and neointimal growth. Moreover, evidence suggests antioxidants improve re-endothelialization and inhibit ISR. By promoting, rather than blocking, the healing process, antioxidant and other therapies may offer an alternative or additional approach over the antiproliferative approaches common to many current devices.
Watt
Jonathan
J
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, Scotland, UK. j.watt@strath.ac.uk
Wadsworth
Roger
R
Kennedy
Simon
S
Oldroyd
Keith G
KG
D000975:Antioxidants / Q000627:therapeutic use*; D023903:Coronary Restenosis / Q000209:etiology / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000293:injuries / Q000473:pathology; D014945:Wound Healing
D000975:Antioxidants