title: Individualized prediction of colon cancer recurrence using a nomogram.
abstract: OBJECTIVE
  Estimates of recurrence after curative colon cancer surgery are integral to patient care, forming the basis of cancer staging and treatment planning. The categoric staging system of the American Joint Committee on Cancer (AJCC) is commonly used to convey risk by grouping patients based on anatomic elements. Although easy to implement, there remains significant heterogeneity within each stage grouping. In the era of multimodality treatment, a more refined tool is needed to predict recurrence.
  
  
  METHODS
  An institutional database of 1,320 patients with nonmetastatic colon cancer was used to develop a nomogram to estimate recurrence after curative surgery. Prognostic factors were assessed with multivariable analysis using Cox regression, whereas nonlinear continuous variables were modeled with cubic splines. The model was internally validated with bootstrapping, and performance was assessed by concordance index and a calibration curve.
  
  
  RESULTS
  The colon cancer recurrence nomogram predicted relapse with a concordance index of 0.77, improving on the stratification provided by either the AJCC fifth or sixth staging scheme. Factors in the model included patient age, tumor location, preoperative carcinoembryonic antigen, T stage, numbers of positive and negative lymph nodes, lymphovascular invasion, perineural invasion, and use of postoperative chemotherapy.
  
  
  CONCLUSIONS
  Using common clinicopathologic factors, the recurrence nomogram is better able to account for tumor and patient heterogeneity, thereby providing a more individualized outcome prognostication than that afforded by the AJCC categoric system. By identifying both the high- and low-risk patients within any particular stage, the nomogram is expected to aid in treatment planning and future trial design.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA. weiser1@mskcc.org
authors.forename: Martin R
authors.initials: MR
authors.lastname: Weiser
authors.forename: Ron G
authors.initials: RG
authors.lastname: Landmann
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kattan
authors.forename: Mithat
authors.initials: M
authors.lastname: Gonen
authors.forename: Jinru
authors.initials: J
authors.lastname: Shia
authors.forename: Joanne
authors.initials: J
authors.lastname: Chou
authors.forename: Philip B
authors.initials: PB
authors.lastname: Paty
authors.forename: José G
authors.initials: JG
authors.lastname: Guillem
authors.forename: Larissa K
authors.initials: LK
authors.lastname: Temple
authors.forename: Deborah
authors.initials: D
authors.lastname: Schrag
authors.forename: Leonard B
authors.initials: LB
authors.lastname: Saltz
authors.forename: W Douglas
authors.initials: WD
authors.lastname: Wong
mesh_terms: D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D015653:Cystectomy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009367:Neoplasm Staging; D049451:Nomograms; D011237:Predictive Value of Tests; D016896:Treatment Outcome