Pulmonary and systemic toxicity of bleomycin on severe combined immune deficiency mice.
Severe combined immune deficiency (SCID) mice were more sensitive to systemic delivery of bleomycin (BLM) than the wild-type strain, and died from esophagitis. Lung injury in the SCID mice by its intratracheal injection, however, was of comparable degree but with less lymphocyte infiltration than that in the wild-type mice. Macrophages and lymphocytes increased transiently in bronchoalveolar lavage fluid of SCID mice, whereas their increase in wild-type was continuous. Unsustainable inflammation in the lung might reduce BLM-induced lung injury in BLM-sensitive SCID mice.
Miyazawa
Hiroshi
H
Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Takiguchi
Yuichi
Y
Hiroshima
Kenzo
K
Kurosu
Katsushi
K
Tada
Yuji
Y
Kasahara
Yasunori
Y
Sakao
Seiichiro
S
Tanabe
Nobuhiro
N
Tatsumi
Koichiro
K
Kuriyama
Takayuki
T
D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002465:Cell Movement; D004941:Esophagitis / Q000139:chemically induced*; D008171:Lung Diseases / Q000139:chemically induced*; D008214:Lymphocytes; D008264:Macrophages; D051379:Mice; D016513:Mice, SCID
D001761:Bleomycin