title: Appetite stimulants use in cystic fibrosis.
abstract: Cystic fibrosis (CF) is an autosomal recessive disease. It affects multiple body organs. The lungs and pancreas are the most affected which results in progressive lung damage and pancreatic insufficiency. Due to the disease process, CF patients require significantly higher caloric intake than recommended for other individuals. The nutritional goal for CF patients is to achieve normal growth and development and, once genetic potential is reached, to maintain good nutritional status throughout life. Evidence has shown that lung function is closely associated with nutritional status in CF and that nutritional status is an independent predictor of survival. Most CF patients are on a high calorie diet to help achieve normal growth and development and maintain good lung function. Inadequate caloric intake in CF can lead to malnutrition. Malnutrition in CF requires careful, multidisciplinary history taking, physical exam, and overall patient/family assessment. Only by determining the actual cause of the malnutrition can appropriate and safe therapies be used to treat it. Appetite stimulants, although efficacious in treating malnutrition in CF, should only be prescribed if decreased food intake secondary to inadequate appetite is the principal cause of the malnutrition and all other contributing factors have been assessed, ruled-out or treated. In this review, we attempted to summarize the use of several appetite stimulants used in CF and other diseases to improve appetite and maximize caloric intake.
authors.affiliation: Pediatric Pulmonology, University of Michigan Health System, Ann Arbor, Michigan 48109-5212, USA. snasr@med.umich.edu
authors.forename: Samya Z
authors.initials: SZ
authors.lastname: Nasr
authors.forename: Donna
authors.initials: D
authors.lastname: Drury
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D019167:Appetite Stimulants / Q000627:therapeutic use*; D002648:Child; D015362:Child Nutrition Disorders / Q000150:complications / Q000209:etiology / Q000517:prevention & control*; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D006803:Human Development; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D015596:Nutrition Assessment
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D019167:Appetite Stimulants; D019382:Human Growth Hormone