title: Cell death: tipping the balance of autoimmunity and tissue repair.
abstract: Inflammation is a key homeostatic process elicited by microbial components and by tissue damage. Increasing evidence indicates that the outcomes either tissue repair or persistent inflammatory damage and degeneration tightly depend on the pattern of cell death in situ and on infiltrating leukocytes and antigen presenting cells. Defects in the initiation and execution steps of programmed cell death such as in the clearance of cell debris are indeed often associated to inflammation defective repair and autoimmunity. Here we report recent developments on the control of apoptosis induction and execution discussing how cell death may be exploited for therapeutic purposes and the links between cell death persisting inflammation and stem cell recruitment and activation in experimental models of complex human diseases such as muscular dystrophy and cancer.
authors.affiliation: H San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rovere-Querini
authors.forename: Silvia
authors.initials: S
authors.lastname: Brunelli
authors.forename: Emilio
authors.initials: E
authors.lastname: Clementi
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Manfredi
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D015551:Autoimmunity / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000378:metabolism; D009136:Muscular Dystrophies / Q000503:physiopathology / Q000628:therapy; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D013234:Stem Cells / Q000502:physiology