title: Ovarian carcinoma associated with pregnancy: a clinicopathologic analysis of 23 cases and review of the literature.
abstract: BACKGROUND
  The aim of this study was to analyze and describe cases of ovarian cancer in pregnant women treated at our center and to review the literature concerned, and to discuss the rationale for therapy.
  
  
  METHODS
  Twenty-Three patients of ovarian malignancies during pregnancy were treated at Vali- Asr Hospital between 1991 and 2002. Data on treatment and follow-up were evaluated.
  
  
  RESULTS
  The incidence of ovarian carcinoma associated with pregnancy in our series was 0.083/1000 deliveries. Eleven (47.8%) were found with ovarian malignant germ cell tumors, five (21.7%) with low malignant potential tumors, four (17.4%) with invasive epithelial tumors, and three (13%) with sex cord stromal tumors. Seventeen (73.9%) of the patients were diagnosed in stage I and had complete remission. Five of the six in advanced stage died. The mean follow-up was 36.3 months. The prognosis was significantly related with stage and histological type (P < 0.05). Sixteen healthy live babies were recorded in this group, and two premature newborn died of respiratory distress syndrome. Chemotherapy was administered to 44% of the patients, in two cases during pregnancy. Overall survival at 5 years was 61%. In most of case conservative surgical treatment could be performed with adequate staging and debulking.
  
  
  CONCLUSIONS
  Early finding of ascitis by ultrasound and persistent large ovarian mass during pregnancy may be related to malignancy and advanced stage. Pregnant women in advanced stage of ovarian cancer seem to have poor prognosis.
authors.affiliation: Gynecologic Oncology Fellowship from Tehran University Of Medical Science, Shahid Sadoughi University Of Medical Science, Shahid Sadoughi Hospital, Yazd, Iran. nadbehtash@yahoo.com
authors.forename: Nadereh
authors.initials: N
authors.lastname: Behtash
authors.forename: Mojgan
authors.initials: M
authors.lastname: Karimi Zarchi
authors.forename: Mitra
authors.initials: M
authors.lastname: Modares Gilani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ghaemmaghami
authors.forename: Azamsadat
authors.initials: A
authors.lastname: Mousavi
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ghotbizadeh
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies