[A case report of inoperable gastric cancer demonstrating a clinical CR after chemo-radiation therapy employing weekly DOC].
A 76-year-old man was admitted to our hospital complaining a weight loss and dysphagia. Gastro-intestinal fiberscopy (GIF) examination showed an early gastric cancer located at cardia. Because of his severe co-morbidities, such as unruptured intracranial aneurysm and idiopathic ventricular fibrillation, he was considered to be inoperable and only followed periodically by the GIF examination every half year. After 3 years since his first examination, the gastric cancer progressed to be T2 advanced gastric cancer. Chemo-radiation therapy (CRT) was administered for consecutive 5 weeks in the following fashion: weekly docetaxel (DOC) div 20 mg/m2 x 5 weeks, and RT 1.8 Gy/day x 5 days/week x 5 weeks. Although the CRT was completed on schedule, diarrhea of grade 3, serum creatinine elevation of grade 2, and esophageal candidiasis appeared during the therapy. A month later after the completion of CRT, the tumor disappeared thoroughly, leaving the tiny redness on the mucosa of cardia. Two months later after CRT, GIF examination reconfirmed the disappearance of the tumor. The patient has shown a clinical complete response (CR), suggesting the efficacy of CRT for inoperable gastric cancer.
Ohmura
Yoshiaki
Y
Dept. of Surgery, National Hospital Organization, Osaka National Hospital.
Fujitani
Kazumasa
K
Yamasaki
Hideya
H
Hirao
Motohiro
M
Yasui
Masayoshi
M
Masuda
Norikazu
N
Kashiwazaki
Masaki
M
Ikenaga
Masakazu
M
Miyazaki
Michihiko
M
Takami
Koji
K
Mishima
Hideyuki
H
Nakamori
Shoji
S
Tsujinaka
Toshimasa
T
D000368:Aged; D000077143:Docetaxel; D005773:Gastroscopy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D043823:Taxoids / Q000627:therapeutic use*; D013997:Time Factors
D011838:Radiation-Sensitizing Agents; D043823:Taxoids; D000077143:Docetaxel