Evaluation of cellulose xanthate-metal-tetracycline complexes as a polymeric antibacterial agent with prolonged antibacterial activity.
Cellulose xanthate-metal-tetracycline complexes (MCX-metal-Tc) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose was chemically modified to cellulose xanthate (MCX). The amount of metal bound to MCX was 0.36 mmol Cu(II)/g MCX and 0.26 mmol Zn(II)/g MCX. Tetracycline (Tc) bound to MCX-metal chelates was 0.08 mmol/g MCX-Cu(II) and 0.04 mmol/g MCX-Zn(II). The Tc release from MCX-metal-Tc was greatly sustained compared with that from a mixture of cellulose/metal/Tc. Furthermore, MCX-metal-Tc manifested antibacterial activity that lasted for 7-22 days. These results suggest that MCX-metal-Tc is a polymeric antibacterial agent with prolonged antibacterial activity.
Jung
Yunjin
Y
Laboratory of Biomedicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea.
Kim
Young Mi
YM
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003300:Copper / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D021902:Enterobacter aerogenes / Q000187:drug effects / Q000254:growth & development; D006863:Hydrogen-Ion Concentration; D009566:Nitrates / Q000737:chemistry*; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013752:Tetracycline / Q000737:chemistry* / Q000494:pharmacology; D013997:Time Factors; D014970:Xanthines / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009566:Nitrates; D014970:Xanthines; D017967:Zinc Compounds; C528876:cellulose xanthate; D003300:Copper; D002482:Cellulose; C516433:copper(II) nitrate; C042103:zinc nitrate; D013752:Tetracycline; C109691:microcrystalline cellulose