title: "One-pot" syntheses of malondialdehyde adducts of nucleosides.
abstract: Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.
authors.affiliation: Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Institute of Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37235-1822, USA.
authors.forename: Jozsef
authors.initials: J
authors.lastname: Szekely
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Peplowski
authors.forename: Charles G
authors.initials: CG
authors.lastname: Knutson
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Marnett
authors.forename: Carmelo J
authors.initials: CJ
authors.lastname: Rizzo
mesh_terms: D018736:DNA Adducts / Q000138:chemical synthesis* / Q000737:chemistry; D008315:Malondialdehyde / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D018736:DNA Adducts; D009705:Nucleosides; D008315:Malondialdehyde