title: Extramedullary relapses after allogeneic non-myeloablative stem cell transplantation in multiple myeloma patients do not negatively affect treatment outcome.
abstract: Recent literature suggests that after non-myeloablative allogeneic (NMA) stem cell transplantation (SCT), the incidence of extramedullary (EM) relapse in multiple myeloma (MM) patients is increased and that these relapses have a poor prognosis. However, numbers on incidence and treatment outcome are scarce. We collected data from 54 relapsed MM patients from a total group of 172 treated with sequential autologous and allogeneic NMA SCT at seven transplantation centres. There were 43 (79.6%) systemic relapses, including 6 with concurrent EM localisation. Five patients had a local EM relapse only. Six patients relapsed with only bone involvement. Patients with deletion of chromosome 13 had a higher incidence of EM relapse (30.8 versus 5.6%, P=0.06). EM relapses were treated with donor lymphocyte infusion, radiotherapy, or chemotherapy, especially with novel agents. The response rate was 45.5%, which was not different when compared to patients without EM disease (54.1%). Overall survival and progression-free survival were not significantly different in patients with EM disease, when compared to those without EM disease. In conclusion, the incidence of relapse with EM disease following allogeneic NMA SCT was 20.4%. There was no negative impact of EM relapse on response rate, overall survival and progression-free survival.
authors.affiliation: Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands. m.c.minnema@umcutrecht.nl
authors.forename: M C
authors.initials: MC
authors.lastname: Minnema
authors.forename: N W C J
authors.initials: NW
authors.lastname: van de Donk
authors.forename: S
authors.initials: S
authors.lastname: Zweegman
authors.forename: U
authors.initials: U
authors.lastname: Hegenbart
authors.forename: S
authors.initials: S
authors.lastname: Schonland
authors.forename: R
authors.initials: R
authors.lastname: Raymakers
authors.forename: J M J M
authors.initials: JM
authors.lastname: Zijlmans
authors.forename: M J
authors.initials: MJ
authors.lastname: Kersten
authors.forename: G M J
authors.initials: GM
authors.lastname: Bos
authors.forename: H M
authors.initials: HM
authors.lastname: Lokhorst
mesh_terms: D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019520:Living Donors; D017710:Lymphocyte Transfusion; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000401:mortality / Q000517:prevention & control*; D012008:Recurrence; D033581:Stem Cell Transplantation; D015996:Survival Rate; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous