Impaired object manipulation in mildly involved individuals with multiple sclerosis.
We investigated hand function in mildly involved multiple sclerosis (MS) patients (N = 16; Expanded Disability Status Scale 1-5, 9-hole peg test 14-32 s) during static and dynamic manipulation tasks using an instrumented device. When compared with healthy controls (N = 16), the patients revealed impaired task performance regarding their ability to exert prescribed patterns of load force (L; force acting tangentially at the digits-object surface). Regarding the coordination of grip force (G; normal component) and L, the data only revealed an elevated G/L ratio, although both the G and L coupling (maximum correlation coefficients and the time lags between them) and the G modulation (gain and offset of G with respect to L) remained comparable in the two groups. Finally, most of the data suggested no MS-specific effects of switching from uni- to bimanual tasks, from available visual feedback to deprived feedback conditions. We conclude that the deterioration in the ability for precise control of external forces and overgripping could precede the decoupling of G and L and decreased G modulation in early phases of the disease. The results also suggest that the applied methodology could be sensitive enough to detect mild levels of impairment of hand function in MS and, possibly, other neurological diseases.
Krishnan
Vennila
V
Department of Health, Nutrition, and Exercise Sciences, University of Delaware, Newark, DE 19716, USA.
de Freitas
Paulo Barbosa
PB
Jaric
Slobodan
S
D000328:Adult; D004185:Disability Evaluation; D005260:Female; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000209:etiology*; D012720:Severity of Illness Index