MIB-1, Bcl-2 and p53 in odontogenic myxomas of the jaws.
Odontogenic myxoma is a rare benign neoplasm occurring in the jaws. Microscopically, it is composed of spindle or stellate-shaped cells arranged in a mucinous matrix. In some cases (20%), odontogenic epithelial islands may be found. The Authors evaluated p53, MIB-1, and Bcl-2 expressed by the epithelial and stromal elements in 12 cases of odontogenic myxoma of the jaws. The cells of the odontogenic epithelium were positive for Bcl-2, p53 and MIB-1. The stromal cell showed a high positivity for MIB-1. Proliferation of both the epithelial and stromal components could be related to the growth of this odontogenic tumour.
Iezzi
G
G
Dental School, University of Chieti-Pescara, Chieti, Italy.
Piattelli
A
A
Rubini
C
C
Artese
L
L
Fioroni
M
M
Carinci
F
F
D000293:Adolescent; D000328:Adult; D019254:Genes, bcl-2 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008339:Mandibular Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009232:Myxoma / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D009808:Odontogenic Tumors / Q000235:genetics* / Q000473:pathology*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases