title: One-step synthesis of substituted dihydro- and tetrahydroisoquinolines by FeCl3.6H2O catalyzed intramolecular Friedel-Crafts reaction of benzylamino-substituted propargylic alcohols.
abstract: A mild, versatile, and efficient method for the one-step synthesis of substituted dihydro- and tetrahydroisoquinolines has been developed by the FeCl3.6H2O catalyzed intramolecular allenylation/cyclization reaction of benzylamino-substituted propargylic alcohols, representing the first example of the intramolecular Friedel-Crafts reaction of propargylic alcohols.
authors.affiliation: Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.forename: Quansheng
authors.initials: Q
authors.lastname: Shen
authors.forename: Jialiang
authors.initials: J
authors.lastname: Wang
authors.forename: Xigeng
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D008958:Models, Molecular; D020005:Propanols / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000480:Alkynes; D002712:Chlorides; D005290:Ferric Compounds; D020005:Propanols; D044005:Tetrahydroisoquinolines; D014867:Water; C028255:propargyl alcohol; C024555:ferric chloride