The androgen receptor CAG and GGN repeat polymorphisms and prostate cancer susceptibility in African-American men: results from the Flint Men's Health Study.
Repeat lengths of the CAG and GGN microsatellites in exon 1 of the androgen receptor (AR) gene have been hypothesized to be associated with prostate cancer risk. In vitro studies have showed an inverse association between AR CAG and GGN repeat length and activity levels of the AR product. It is known that men of African descent have a higher incidence of and greater mortality from prostate cancer than men of Caucasian or Asian descent and, on average, a smaller number of repeats at AR CAG and GGN. Consistent with these findings, studies have also found increased AR protein expression levels in benign prostatic hyperplasia and prostatic diseased tissues from men of African descent. Despite these findings, limited studies have been conducted to evaluate the association between repeat lengths at AR CAG and prostate cancer risk in African Americans. Our study is the first such study to examine whether repeat length of the AR GGN repeat is associated with prostate cancer risk in African Americans. We found no evidence for an association between AR CAG or GGN repeat lengths and prostate cancer risk in a population-based sample of African Americans.
Lange
Ethan M
EM
Department of Genetics, University of North Carolina-Chapel Hill, 4300D MBRB, CB# 7264, 111 Mason Farm Road, Chapel Hill, NC, 27599-7264, USA. elange@med.unc.edu.|Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA. elange@med.unc.edu.|Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA. elange@med.unc.edu.
Sarma
Aruna V
AV
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Ray
Anna
A
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Wang
Yunfei
Y
Department of Genetics, University of North Carolina-Chapel Hill, 4300D MBRB, CB# 7264, 111 Mason Farm Road, Chapel Hill, NC, 27599-7264, USA.
Ho
Lindsey A
LA
Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Anderson
Sarah A
SA
Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, Rochester, MN, USA.
Cunningham
Julie M
JM
Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, Rochester, MN, USA.
Cooney
Kathleen A
KA
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.|Department of Urology, University of Michigan, Ann Arbor, MI, USA.|University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats; D014481:United States / Q000453:epidemiology; D001741:Black or African American
D011944:Receptors, Androgen