title: [Acute lung injury and alveolar epithelial function].
abstract: Since its original definition forty years ago, acute lung injury/acute respiratory distress syndrome has been a challenging target for both clinicians and researchers. In this review, several progresses in the past decades in the area of research concerning the pathophysiology of alveolar epithelium in this syndrome are discussed. Understanding the mechanism of tissue injury and tissue repair are key points to develop new strategy for clinical evaluation of severity of this syndrome and possible therapeutic approaches in future.
authors.affiliation: Department of Anesthesiology, Graduate School of Medicne, Tokyo Medical and Dental University, Tokyo.
authors.forename: Tokujiro
authors.initials: T
authors.lastname: Uchida
authors.forename: Koshi
authors.initials: K
authors.lastname: Makita
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D004848:Epithelium / Q000503:physiopathology; D006801:Humans; D011650:Pulmonary Alveoli / Q000503:physiopathology*; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D015415:Biomarkers