Antiphospholipid syndromes in infectious diseases.
Antiphospholipid antibodies are essential in the diagnosis of antiphospholipid syndrome (APS), or the classic "Hughes syndrome," which is a systemic disorder that is autoimmune in nature. They are also found in various infections in low titers without any evidence of thrombotic manifestations of APS. However, in a few infections, when antiphospholipid antibodies are associated with protein cofactor, there can be associated thrombosis. Different infections are also responsible for triggering a subset of lethal APS, acute catastrophic APS. This situation requires prompt diagnosis and aggressive treatment of the infection to prevent severe complications.
Amin
Navin M
NM
David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. aminn@kernmedctr.com
D017152:Antibodies, Antiphospholipid; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002388:Catastrophic Illness; D003141:Communicable Diseases / Q000150:complications* / Q000276:immunology*; D006801:Humans
D017152:Antibodies, Antiphospholipid