title: Successful resolution of cardiac mycetomas by combined liposomal Amphotericin B with Fluconazole treatment in premature neonates.
abstract: This manuscript reports on two very low birth weight premature infants with respiratory distress, receiving parenteral nutrition and broad-spectrum antibiotics for about 3 weeks, who developed Candida albicans sepsis associated with fungal mycoses and endocarditis, despite treatment with Amphotericin B and Caspofungin. On days 40 and 47, respectively, antifungal therapy was modified to liposomal Amphotericin B combined with Fluconazole 6 mg/kg/day for 4 weeks, resulting in complete resolution of the mycetomas. Our observations suggest that the combination of liposomal Amphotericin B with Fluconazole is able to result in complete resolution of cardiac mycetomas in preterm infants.
authors.affiliation: Department of Paediatrics, Neonatal Intensive Care Unit, General University Hospital of Patras, 26504, Rio, Patras, Greece.
authors.forename: Ageliki A
authors.initials: AA
authors.lastname: Karatza
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dimitriou
authors.forename: Markos
authors.initials: M
authors.lastname: Marangos
authors.forename: Myrto
authors.initials: M
authors.lastname: Christofidou
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Pavlou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Giannakopoulos
authors.forename: Antonios
authors.initials: A
authors.lastname: Darzentas
authors.forename: Stefanos P
authors.initials: SP
authors.lastname: Mantagos
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy*; D004338:Drug Combinations; D004696:Endocarditis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008081:Liposomes; D008297:Male; D008271:Mycetoma / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D008081:Liposomes; D000666:Amphotericin B; D015725:Fluconazole