Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia.
A rare case of combined unilateral adrenal hyperplasia and paraganglioma is reported. A 27-year-old woman presented with hypertension, palpitation, dizziness, and headache for about 3 months. Elevated plasma aldosterone with low renin and a high level of urine vanillylmandelic acid (VMA) were found. Computed tomography showed a microadenoma of the left adrenal gland and a well demarcated left retroperitoneal para-aortic mass. Adrenal vein sampling for aldosterone and renin levels suggested left adrenal lesion. Surgical removal of the left adrenal gland and para-aortic mass was performed. Pathologic examination of the resected left adrenal gland showed adrenal cortical hyperplasia and the left retroperitoneal para-aortic mass showed a paraganglioma. Postoperatively, blood pressure, plasma renin, aldosterone and urine VMA all returned to within normal ranges. The possible relationship of these two diseases is discussed.
Chiang
Kuo-Hsuan
KH
Division of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Liou
Jer-Young
JY
Shyu
Kou-Gi
KG
Yeh
Chung-Hsin
CH
Wu
Chin-Chu
CC
Chen
Tong-Jong
TJ
Lo
Huey-Ming
HM
D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D006973:Hypertension / Q000209:etiology*; D010236:Paraganglioma, Extra-Adrenal / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010673:Pheochromocytoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed