[Comparative analysis of efficacy of certain neuroprotectors in ischemic stroke].
Cortexin, nootropil and cerebrolysin have been used as neuroprotective medications in the acute period of ischemic stroke (IS). Clinical efficacy of cortexin and nootropil has been compared in 2 therapeutic series in 35 patients and that of cortexin and cerebrolysin--in 45 patients. The efficacy was assessed using several clinical and psychometric scales with statistical processing of the results. The data obtained suggest that in patients with moderate IS the drugs exert a similar and rather marked effect which was stronger comparing to the treatment without these drugs. At the same time, a domestic neuroprotector cortexin has some advantages, especially with regard to the absence of side-effects and "price-dose-therapeutic effect" criterion.
Skorokhodov
A P
AP
Dudina
A A
AA
Kolesnikova
E A
EA
Koron
A E
AE
Kobantsev
Iu A
IuA
Sedova
A A
AA
D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D004453:Echoencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010455:Peptides / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D011594:Psychometrics / Q000379:methods; D016896:Treatment Outcome
D000596:Amino Acids; D036341:Intercellular Signaling Peptides and Proteins; D018696:Neuroprotective Agents; D010455:Peptides; C006952:cerebrolysin; C056590:cortexin; D010889:Piracetam