The effect of piroxicam on the prevention of postoperative retrosternal and pericardial adhesions.
BACKGROUND
The presence of adhesions after heart operations increases the risk of life-threatening damage to the heart and extracardiac grafts. Infections, tissue injury and inflammations are suspected aetiologic agents. The main purpose of our study is to evaluate the effect of an antiinflammatory agent piroxicam on the formation of retrosternal and pericardial adhesions in a rabbit model.


METHODS
23 of forty-two New Zealand white rabbits were labelled as group P (piroxicam group) and the others as group C (n = 19, control group). All animals were subjected to median sternotomy and abrasion was applied to the epicardium and pericardium. Piroxicam was given only to group P animals 10 mg/kg/day intramuscularly on the day of operation and twice daily for 2 days postoperatively. All animals were sacrificed on the 10th postoperative day. After cardiectomy, the pericardium was totally excised; retrosternal and pericardial adhesions were evaluated and scored. t-PA (tissue plasminogen activator), PAl-I (plasminogen activator inhibitor-I) levels and pericardial tissue myeloperoxidase activities were measured.


RESULTS
More severe retrosternal and pericardial adhesions were observed in the control group (P < 0.05). Mean levels of t-PA were higher in the study group than in the control group (P < 0.05). Mean levels of PAI-I were lower in the study group (P < 0.05). Hence pericardial fibrinolytic capacity was significantly higher in the piroxicam group than in the control group. Myeloperoxidase activities in the pericardium were significantly lower in the study group than in the control group (P < 0.05).


CONCLUSIONS
The use of piroxicam in the perioperative period prevents inflammation, preserves the fibrinolytic capacity of the pericardium and decreases the postoperative pericardial and retrosternal adhesions.
Iskesen
Ihsan
I
Department of Cardiovascular Surgery, Celal Bayar University School of Medicine, Manisa, Turkey. iskesen@yahoo.com
Aksoy
Omer
O
Cerrahoglu
Mustafa
M
Sirin
Hayrettin
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D006348:Cardiac Surgical Procedures; D004195:Disease Models, Animal; D010493:Pericarditis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D010894:Piroxicam / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D011897:Random Allocation; D000267:Tissue Adhesions / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam