title: Correlation of p63 immunoreactivity with tumor grade in meningiomas.
abstract: Predicting tumor behavior in meningiomas based on morphologic features alone remains difficult. The present study was undertaken to assess the correlation between p63 expression and histological grade of meningiomas. A total of 37 archival intracranial meningiomas were classified into 20 grade I, 13 grade II, and 4 grade III meningiomas. Using immunohistochemical methods, staining was scored based on nuclear and/or cytoplasmic distribution as follows: 0, no staining; 1, 50% or less of the cells; 2, more than 50% of the cells. Of grade I meningiomas, 95% (19/20) lacked nuclear p63 expression and none exhibited cytoplasmic staining. Overall, 92% of grade II tumors showed nuclear expression and 31% (4/13) showed cytoplasmic expression. Grade III tumors showed an overall nuclear expression of 75% (3/4) with all exhibiting cytoplasmic staining. Our results indicate a good correlation exists between histological grade and p63 protein expression, suggesting that p63 expression might be correlated with the clinical outcome.
authors.affiliation: Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. rushinge@afip.osd.mil
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Rushing
authors.forename: Cara
authors.initials: C
authors.lastname: Olsen
authors.forename: Yan-Gao
authors.initials: YG
authors.lastname: Man
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis*; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins