title: The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan.
abstract: Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements.
authors.affiliation: Laboratory of Biochemistry, Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.
authors.forename: Aikkarach
authors.initials: A
authors.lastname: Kettawan
authors.forename: Chitsopa
authors.initials: C
authors.lastname: Kunthida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takeo
authors.initials: T
authors.lastname: Kishi
authors.forename: Jun
authors.initials: J
authors.lastname: Chikazawa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sakata
authors.forename: Eiji
authors.initials: E
authors.lastname: Yano
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watabe
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto