title: Parallel algorithms for maximum a posteriori estimation of spin density and spin-spin decay in magnetic resonance imaging.
abstract: A maximum a posteriori (MAP) algorithm is presented for the estimation of spin-density and spin-spin decay distributions from frequency and phase-encoded magnetic resonance imaging data. Linear spatial localization gradients are assumed: the y-encode gradient applied during the phase preparation time of duration tau before measurement collection, and the x-encode gradient applied during the full data collection time t>/=0. The MRI signal model developed in M.I. Miller et al., J. Magn. Reson., ser. B (Apr. 1995) is used in which a signal resulting from M phase encodes (rows) and N frequency encode dimensions (columns) is modeled as a superposition of MN sinc-modulated exponentially decaying sinusoids with unknown spin-density and spin-spin decay parameters. The nonlinear least-squares MAP estimate of the spin density and spin-spin decay distributions solves for the 2MN spin-density and decay parameters minimizing the squared-error between the measured data and the sine-modulated exponentially decay signal model using an iterative expectation-maximization algorithm. A covariance diagonalizing transformation is derived which decouples the joint estimation of MN sinusoids into M separate N sinusoid optimizations, yielding an order of magnitude speed up in convergence. The MAP solutions are demonstrated to deliver a decrease in standard deviation of image parameter estimates on brain phantom data of greater than a factor of two over Fourier-based estimators of the spin density and spin-spin decay distributions. A parallel processor implementation is demonstrated which maps the N sinusoid coupled minimization to separate individual simple minimizations, one for each processor.
authors.affiliation: Mallinckrodt Inst. of Radiol., Washington Univ. Sch. of Med., St. Louis, MO.
authors.forename: T J
authors.initials: TJ
authors.lastname: Schaewe
authors.forename: M I
authors.initials: MI
authors.lastname: Miller