COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population.
BACKGROUND
Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied.


METHODS
Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks.


RESULTS
We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk.


CONCLUSIONS
These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
Hou
Lifang
L
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA. l-hou@northwestern.edu
Grillo
Paolo
P
Zhu
Zhong-Zheng
ZZ
Lissowska
Jola
J
Yeager
Meredith
M
Zatonski
Witold
W
Zhu
Guanshan
G
Baccarelli
Andrea
A
Chanock
Stephen J
SJ
Fraumeni
Joseph F
JF
Chow
Wong-Ho
WH
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D051545:Cyclooxygenase 1 / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*
D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2