title: Comparison of weight gain in treatments for Tourette syndrome: tetrabenazine versus neuroleptic drugs.
abstract: Weight gain occurs with most neuroleptic drugs used to treat tics. Tetrabenazine, a vesicular monoamine transporter type 2 inhibitor, inhibits dopamine release. It is used to treat a variety of hyperkinetic movement disorders, including tics. Weight gain over time was compared in a group of pediatric tic patients taking only tetrabenazine with an age-matched group of tic patients taking only neuroleptic drugs. Age in the tetrabenazine group (n = 36, 32 males) at initial therapy was 13.4 (SD 3.3) years. They were monitored for 25.2 (SD 12.3) months. The average dose of tetrabenazine (all visits) was 54.4 (SD 26.6) mg/d. In the neuroleptic group (n = 41, 33 males), the age at therapy onset was 12.3 +/- 4.0 years. They were monitored for 18.9 (SD 14.8) months. Weight increase was 0.8 lb/mo in the tetrabenazine group compared with 1.7 lb/mo in the neuroleptic group (P = .006). Most patients who switched from a neuroleptic drug to tetrabenazine subsequently lost weight. Although the study was not designed to compare efficacy, this tended to be greater with tetrabenazine than with neuroleptic drugs.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. wondo@bcm.tmc.edu
authors.forename: William G
authors.initials: WG
authors.lastname: Ondo
authors.forename: Daniel
authors.initials: D
authors.lastname: Jong
authors.forename: Anthony
authors.initials: A
authors.lastname: Davis
mesh_terms: D000293:Adolescent; D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013747:Tetrabenazine / Q000494:pharmacology* / Q000627:therapeutic use; D005879:Tourette Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D014150:Antipsychotic Agents; D013747:Tetrabenazine