title: Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin.
abstract: Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-alpha high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.
authors.affiliation: Institute of General Pathology, Laboratory of Clinical Pathology, University of Milan, Via L. Mangiagalli 31, I-20133 Milan, Italy. mmcorsi@unimi.it
authors.forename: Massimiliano M
authors.initials: MM
authors.lastname: Corsi
authors.forename: Giada
authors.initials: G
authors.lastname: Dogliotti
authors.forename: Francesca
authors.initials: F
authors.lastname: Pedroni
authors.forename: Emanuela
authors.initials: E
authors.lastname: Galliera
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Malavazos
authors.forename: Roberto
authors.initials: R
authors.lastname: Villa
authors.forename: Martina
authors.initials: M
authors.lastname: Chiappelli
authors.forename: Federico
authors.initials: F
authors.lastname: Licastro
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D015850:Interleukin-6 / Q000097:blood; D007558:Italy / Q000453:epidemiology; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D008955:Models, Cardiovascular; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha