title: The effect of early surgical treatment of traumatic spine injuries on patient mortality.
abstract: BACKGROUND
  The ideal timing of spinal fixation is controversial. A recent study showed that early spine fixation reduced morbidity and resource utilization. We previously noted a trend toward higher mortality in patients undergoing early spinal fixation. This study was done to analyze whether the timing of spinal fixation had a significant effect on mortality.
  
  
  METHODS
  The registry of our Level I trauma program was queried for all patients with at least one spinal vertebral injury. Anatomic and physiologic variables included age, initial Glasgow Coma Scale score, systolic blood pressure, heart rate, and Injury Severity Score. Outcome was evaluated in terms of ventilator days, intensive care unit length of stay, hospital length of stay (HLOS), and mortality. Patients were stratified by day of spinal operative fixation as early when done within 48 hours and late when done after 48 hours. Data were analyzed using chi and an unpaired t test, accepting p < 0.05 as significant.
  
  
  RESULTS
  Three hundred sixty-one patients between January 1988 and February 2003 required operative spinal fixation (158 early, within 48 hours vs. 203 late, beyond 48 hours). There was no significant difference between the two groups except mortality, which was significantly higher in the early group (7.6 vs. 2.5%; p = 0.0257), and HLOS, which was significantly shorter in the early group (14.42 vs. 17.64 days; p = 0.025).
  
  
  CONCLUSIONS
  Spinal fixation within 48 hours after vertebral fractures and dislocations appears to increase mortality despite similar anatomic and physiologic parameters in the later operative group. Incomplete resuscitation of patients before surgery may have contributed to this result. The shorter HLOS may have been because of the higher number of early deaths. Prospective studies to identify the optimal timing of spinal fixation and the reason for these outcome differences are warranted.
authors.affiliation: Department of Surgery, Division of Trauma and Critical Care, Health Science Center-Jacksonville, University of Florida, Jacksonville, Florida, USA. andy.kerwin@jax.ufl.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Kerwin
authors.forename: Eric R
authors.initials: ER
authors.lastname: Frykberg
authors.forename: Miren A
authors.initials: MA
authors.lastname: Schinco
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Griffen
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Arce
authors.forename: Tai Q
authors.initials: TQ
authors.lastname: Nguyen
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Tepas
mesh_terms: D000328:Adult; D002574:Cervical Vertebrae / Q000293:injuries*; D005260:Female; D005593:Fracture Fixation, Internal / Q000009:adverse effects / Q000706:statistics & numerical data*; D006801:Humans; D015601:Injury Severity Score; D008159:Lumbar Vertebrae / Q000293:injuries*; D008297:Male; D011014:Pneumonia / Q000209:etiology; D011183:Postoperative Complications; D016103:Spinal Fractures / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000293:injuries*; D013997:Time Factors; D014193:Trauma Centers / Q000706:statistics & numerical data*; D014949:Wounds, Nonpenetrating / Q000209:etiology / Q000401:mortality / Q000601:surgery*