title: [Antiphospholipid syndrome: modern problems].
abstract: The article describes the historical aspects of the formation of the notion antiphospholipid syndrome (AFS) as well as the development of the conception of its clinical symptoms and laboratory tests confirming the diagnosis. Special attention is paid to the modern interpretation of the notion of AFS, which excludes a number of clinical symptoms and laboratory tests and defines more clearly the use of the rest of clinical and laboratory signs. Theoretical concepts of the pathogenetic mechanisms of the development of this disease and its association with congenital thrombofilias are adduced. Unsolved issues of understanding of AFS problem by clinicians are discussed. The author makes suggestions on the diagnostic criteria of true AFS.
authors.forename: I N
authors.initials: IN
authors.lastname: Bokarev
authors.forename: A V
authors.initials: AV
authors.lastname: Arshinov
authors.forename: A L
authors.initials: AL
authors.lastname: Mel'nikov
mesh_terms: D016736:Antiphospholipid Syndrome / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006801:Humans