title: [Respiratory lesions in Congo-Crimean hemorrhagic fever].
abstract: OBJECTIVE
  To characterize pathogenesis, clinical, laboratory and x-ray features of respiratory disease in Congo-Crimean hemorrhagic fever (CCHF).
  
  
  METHODS
  CCHF diagnosis was made in 283 patients basing on the detection in blood of specific antibodies by enzyme immunoassay (EIA) and virus RNA by polymerase chain reaction (PCR). Serum cytokines were measured with EIA.
  
  
  RESULTS
  Pulmonary lesion in CCHF had characteristics of acute respiratory distress syndrome (ARDS). It manifested in the hemorrhagic period with blood spitting, pulmonary hemorrhage and bleeding into the pleural cavity. A high level of proinflammatory cytokines in the blood correlated with the disease severity.
  
  
  CONCLUSIONS
  Respiratory affection in CCHF was seen at all the stages of the infectious process. ARDS occurs during hemorrhagic manifestations and is accompanied with systemic inflammatory reaction.
authors.forename: I V
authors.initials: IV
authors.lastname: Sannikova
authors.forename: V D
authors.initials: VD
authors.lastname: Pacechnikov
authors.forename: V V
authors.initials: VV
authors.lastname: Maleev
mesh_terms: D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001803:Blood Transfusion / Q000379:methods; D016207:Cytokines / Q000276:immunology; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000302:isolation & purification*; D006479:Hemorrhagic Fever, Crimean / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology / Q000628:therapy / Q000821:virology; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology / Q000628:therapy / Q000821:virology*; D012254:Ribavirin / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D007074:Immunoglobulin G; D012254:Ribavirin