Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass.
The development of Cardiopulmonary Bypass (CPB) catopulted the field of cardiothoracic surgery into a new dimension--one that changed the lives of individuals with congenital and acquired heart disease worldwide. Despite its contributions, CPB has clear limitations and creates unique challenges for clinicians and patients alike, stemming from profound hemostatic pertubations and accompanying risk for bleeding and possibly thrombotic complications.
Yavari
Maryam
M
Duke Cardiovascular Thrombosis Center, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA.
Becker
Richard C
RC
D015415:Biomarkers; D001777:Blood Coagulation; D016063:Blood Loss, Surgical; D001798:Blood Proteins / Q000032:analysis*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000295:instrumentation; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000097:blood / Q000601:surgery; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation; D015949:Factor IXa / Q000032:analysis / Q000502:physiology; D005342:Fibrinolysis; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006438:Hemodilution / Q000009:adverse effects; D006801:Humans; D007432:Intraoperative Period; D019106:Postoperative Hemorrhage / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D011184:Postoperative Period; D013917:Thrombin / Q000378:metabolism; D013921:Thrombocytopenia / Q000209:etiology; D013923:Thromboembolism / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D019851:Thrombophilia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000295:instrumentation
D015415:Biomarkers; D001798:Blood Proteins; D015949:Factor IXa; D013917:Thrombin