A numerical study of the blocking of migraine by Rolando sulcus.
Migraine with aura is a complex phenomena, which remains still not completely understood. A striking fact is that its clinical manifestations may change from one patient to another. Migraine with aura may only consist in visual hallucinations, but may as well go on to temporary aphasy. However, for all the patients it always stops before it goes from area 3 to area 4, thus just before crossing Rolando sulcus. In this paper, we give arguments showing that the detailed geometry of Rolando sulcus in human cortex may by itself explain that migraine attack never crosses Rolando sulcus.
Grenier
E
E
Unité de Mathématiques Pures et Appliqués U.M.R. 5669, E.N.S. Lyon, 46 allée d'Italie, 69364 Lyon, et IMTh, France. egrenier@umpa.ens-lyon.fr
Dronne
M A
MA
Descombes
S
S
Gilquin
H
H
Jaillard
A
A
Hommel
M
M
Boissel
J-P
JP
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D003198:Computer Simulation; D013181:Cortical Spreading Depression; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D009435:Synaptic Transmission