Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation.
B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.
Sun
Tong-Wen
TW
Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China. suntongwen@163.com
Zhang
Shou-Yan
SY
Wang
Le-Xin
LX
D015415:Biomarkers / Q000097:blood; D006084:Graft Rejection / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation; D008954:Models, Biological; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012680:Sensitivity and Specificity; D014184:Transplantation, Homologous
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain