title: [Uric acid, apo-E and apo-C3 correlation in normo- and hyperlipidemia].
abstract: OBJECTIVE
  To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia.
  
  
  METHODS
  Serum lipids, apolipoprotein spectrum and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 58 with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb.
  
  
  RESULTS
  Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences by content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid levels and apo-E in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative.
  
  
  CONCLUSIONS
  Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apo-E and apo-C3. A rise of apo-C3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia.
authors.forename: E R
authors.initials: ER
authors.lastname: Boĭko
authors.forename: A O
authors.initials: AO
authors.lastname: Ovechkin
authors.forename: A M
authors.initials: AM
authors.lastname: Kaneva
authors.forename: N N
authors.initials: NN
authors.lastname: Potolitsyna
authors.forename: S G
authors.initials: SG
authors.lastname: Boĭko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D053305:Apolipoprotein C-III / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D053305:Apolipoprotein C-III; D001057:Apolipoproteins E; D015415:Biomarkers; D014527:Uric Acid