title: Maximal respiratory static pressures in patients with different stages of COPD severity.
abstract: BACKGROUND
  In this study, we analyzed maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) values in a stable COPD population compared with normal subjects. We evaluated the possible correlation between functional maximal respiratory static pressures and functional and anthropometric parameters at different stages of COPD. Furthermore, we considered the possible correlation between airway obstruction and MIP and MEP values.
  
  
  METHODS
  110 patients with stable COPD and 21 age-matched healthy subjects were enrolled in this study. Patients were subdivided according to GOLD guidelines: 31 mild, 39 moderate and 28 severe.
  
  
  RESULTS
  Both MIP and MEP were lower in patients with severe airway impairment than in normal subjects. Moreover, we found a correlation between respiratory muscle function and some functional and anthropometric parameters: FEV1 (forced expiratory volume in one second), FVC (forced vital capacity), PEF (peak expiratory flow), TLC (total lung capacity) and height. MIP and MEP values were lower in patients with severe impairment than in patients with a slight reduction of FEV1.
  
  
  CONCLUSIONS
  The measurement of MIP and MEP indicates the state of respiratory muscles, thus providing clinicians with a further and helpful tool in monitoring the evolution of COPD.
authors.affiliation: Department of Cardiovascular and Respiratory Sciences, UOC Malattie Respiratorie, University of Rome La Sapienza, Italy. cterzano@tin.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Terzano
authors.forename: Daniela
authors.initials: D
authors.lastname: Ceccarelli
authors.forename: Vittoria
authors.initials: V
authors.lastname: Conti
authors.forename: Elda
authors.initials: E
authors.lastname: Graziani
authors.forename: Alberto
authors.initials: A
authors.lastname: Ricci
authors.forename: Angelo
authors.initials: A
authors.lastname: Petroianni
mesh_terms: D000368:Aged; D000403:Airway Resistance; D016022:Case-Control Studies; D045853:Exhalation; D005541:Forced Expiratory Volume; D006801:Humans; D001239:Inhalation; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D011312:Pressure; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000503:physiopathology; D012384:Rome; D012720:Severity of Illness Index; D014109:Total Lung Capacity; D014797:Vital Capacity