Evaluation of psychoemotional status of rats after brain injury and systemic transplantation of mesenchymal stem cells.
We studied the effects of systemic transplantation of mesenchymal stem cells obtained after culturing of autologous bone marrow on psychophysiological status of Wistar rats after diffuse brain trauma. Two months after systemic injection of mesenchymal stem cells we observed a decrease in manifestations of emotional behavioral reactions (anxiety and excitability) and shortening of the time of realization of drinking behavior in a T-maze. A significant positive effect of systemic transfusion of mesenchymal stem cells on avoidance conditioning in a shuttle box was observed 3 months after brain injury.
Tsyb
A F
AF
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
Roshal
L M
LM
Konoplyannikov
A G
AG
Souchkevitch
G N
GN
Verkhovskii
Yu G
YG
Shevchuk
A S
AS
Pavlova
L N
LN
Zhavoronkov
L P
LP
Semenova
J B
JB
Yuzhakov
V V
VV
Kolganova
O I
OI
Lushnikova
G A
GA
Ananyeva
E P
EP
D000818:Animals; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery*; D004644:Emotions / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar