Effect of dimethylsulfoxide on the functions of mesenchymal and hemopoietic precursors.
The effects of dimethylsulfoxide on the state of mesenchymal precursors in vivo were demonstrated. Treatment with dimethylsulfoxide reduced the content of stromal clonogenic elements in the bone marrow and inhibited mobilization of mesenchymal precursors induced by granulocyte colony-stimulating factor. In in vitro system, dimethylsulfoxide inhibited proliferation of fibroblast, erythroid, and granulomonocytic colony-forming units and stimulates maturation of hemopoietic precursors.
Zyuz'kov
G N
GN
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Gur'yantseva
L A
LA
Simanina
E V
EV
Zhdanov
V V
VV
Dygai
A M
AM
Goldberg
E D
ED
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice
D016179:Granulocyte Colony-Stimulating Factor; D004121:Dimethyl Sulfoxide