Management of a child with renal artery stenosis and homozygous factor V Leiden mutation.
Presence of factor V Leiden mutation is a known risk factor for thrombosis. It contributes for premature occlusion of vascular anastomosis. This report describes the intraoperative and postoperative anticoagulation management of a girl with homozygous factor V Leiden mutation and renal artery stenosis after her renovascular reconstruction surgery. This report suggests that postoperative anticoagulation may be helpful for the successful maturation of vascular anastomoses in children with underlying acquired or hereditary risk factors for thrombosis including factor V Leiden mutation.
Sharathkumar
Anjali A
AA
Department of Pediatrics and Communicable Diseases, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI 48109, USA. aalatkar@umich.edu
Stanley
James C
JC
D017130:Angioplasty / Q000379:methods; D000959:Antihypertensive Agents / Q000627:therapeutic use; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005165:Factor V / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D007431:Intraoperative Complications / Q000628:therapy; D009154:Mutation; D011859:Radiography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control; D019851:Thrombophilia / Q000188:drug therapy / Q000235:genetics*; D016896:Treatment Outcome
D000959:Antihypertensive Agents; C095381:factor V Leiden; D005165:Factor V; D006493:Heparin