Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals.
While IgA is proposed to be essential to control rotavirus disease, no information is available how IgA deficient individuals modulate rotavirus disease and immune responses. In this study it was shown that patients (n = 62) with selective IgA deficiency (IgA-D) (<0.05 g/L) resolve rotavirus disease and show higher total IgG and IgG1 subclass antibody titers to rotavirus than IgA proficient individuals (n = 62) (geometric mean titer, GMT) 18,101 vs. 4,000 (P < 0.005); 8,463 vs. 1691, (P < 0.005). It is concluded that IgA is not essential for resolving rotavirus disease in humans.
Istrate
Claudia
C
Instituto de Biologia Experimental e Tecnologica and Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal.
Hinkula
Jorma
J
Hammarström
Lennart
L
Svensson
Lennart
L
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology* / Q000821:virology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology* / Q000821:virology
D000914:Antibodies, Viral; D007074:Immunoglobulin G