title: [Cerebral toxoplasmosis in HIV-infected patients].
abstract: OBJECTIVE
  To detect clinical characteristics of cerebral toxoplasmosis in HIV-infected patients, to clarify diagnostic role of detection of DNA and antibodies to Toxoplasma gondii in the cerebrospinal fluid (CSF) and blood.
  
  
  METHODS
  Diagnostic procedures were performed in 156 patients with HIV infection at the stage IVB (AIDS) in 2003-2006. All the patients suffered from diseases of the central nervous system (CNS). Toxoplasmosis was diagnosed in 57 (36%) cases. Lumbar puncture, MR imaging of the brain, reaction of indirect immunofluorescence, polymerase chain reaction and enzyme immunoassay were made to identify IgM and IgG to T. gondii.
  
  
  RESULTS
  Typical for HIV-infected patients with cerebral toxoplasmosis were focal symptoms of CNS affection, hemipareses, adynamia, mental disorders, intoxication symptoms.
  
  
  CONCLUSIONS
  MR imaging data are very important. Toxoplastosis is characterized by multiple destructive foci in the hemispheres and cerebellum with great amount of the parasites along the periphery of brain tissue necrosis. Detection of the infective agent DNA and specific IgG antibodies in cerebrospinal fluid confirms the presence of toxoplasmosis but sensitivity of the markers is low. IgG antibodies to T. gondii have diagnostic implications if they occur in high and moderate titers.
authors.forename: A B
authors.initials: AB
authors.lastname: Peregudova
authors.forename: V I
authors.initials: VI
authors.lastname: Shakhgil'dian
authors.forename: D B
authors.initials: DB
authors.lastname: Goncharov
authors.forename: T N
authors.initials: TN
authors.lastname: Ermak
authors.forename: I M
authors.initials: IM
authors.lastname: Tishkevich
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Shipulina
authors.forename: N V
authors.initials: NV
authors.lastname: Gorlova
authors.forename: B M
authors.initials: BM
authors.lastname: Gruzdev
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013129:Spinal Puncture; D014122:Toxoplasma / Q000276:immunology / Q000302:isolation & purification; D016781:Toxoplasmosis, Cerebral / Q000453:epidemiology* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M