MicroParticle photophysics illuminates viral bio-sensing.
The authors present an approach for specific and rapid unlabeled detection of a virus by using a microsphere-based whispering gallery mode sensor that transduces the interaction of a whole virus with an anchored antibody. They show theoretically that this sensor can detect a single virion below the mass of HIV. A micro-fluidic device is presented that enables the discrimination between viruses of similar size and shape.
Arnold
S
S
MicroParticle PhotoPhysics Lab, Polytechnic University, 6 Metro Tech Center, Brooklyn, NY 11201, USA. sarnold935@aol.com
Ramjit
R
R
Keng
D
D
Kolchenko
V
V
Teraoka
I
I
D015374:Biosensing Techniques / Q000379:methods*; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D008027:Light; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D014771:Virion / Q000302:isolation & purification*; D014780:Viruses / Q000302:isolation & purification*