title: [Result of surgical treatment and prognostic factors in giant mass lung cancer].
abstract: OBJECTIVE
  To investigate the role of surgery in the treatment of giant mass lung cancer and to analyze prognostic factors affecting surgical result.
  
  
  METHODS
  From August 1992 to August 2005, the clinical data of 137 patients with giant mass lung cancer ( > or =8 cm in diameter) were retrospectively reviewed. 122 cases had radical resection with 63 lobectomies, 48 pneumonectomy and 11 other resection modes, the remaining 15 patients underwent palliative resection. The prognostic factors including sex, tumor size, p-TNM stage, T stage, N stage, histological types and operation extent were analyzed with SPSS 13.0 software. The survival rate was calculated by Kaplan-Meier method and logrank was used for comparing survival difference. Univariate and multivariate prognostic factors for survival were analyzed by Cox proportional hazard regression model.
  
  
  RESULTS
  The overall 1-, 3- and 5-year survival rate was 76.0%, 49.2% and 40.1%, respectively. Sex (P = 0.001), p-TNM stage (P = 0.001), N stage (P = 0.042), surgical approach (P = 0.026) and T stage (P = 0.006) were found to be prognostic factors in Cox univariate analysis. p-TNM stage (P = 0.001) were identified as an independent prognostic factor in Cox multivariate analysis.
  
  
  CONCLUSIONS
  p-TNM stage is the crucial prognostic factor in surgical treatment for giant mass lung cancer. Strict selection of candidate for resection and complete resection may be helpful in improving survival in patient with giant mass lung cancer.
authors.affiliation: Shanghai Pulmonary Disease Hospital, Shanghai 200433, China.
authors.forename: Bao-bin
authors.initials: BB
authors.lastname: Xu
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Rong-xuan
authors.initials: RX
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D047368:Tumor Burden