Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development.
Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.
Cho
Kyoung-Won
KW
Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 project, College of Dentistry, Yonsei University, Seodaemoon-Gu, Seoul, Republic of Korea.
Cho
Sung-Won
SW
Lee
Jong-Min
JM
Lee
Min-Jung
MJ
Gang
Hee-Seok
HS
Jung
Han-Sung
HS
D000818:Animals; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D009055:Mouth / Q000196:embryology* / Q000201:enzymology; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D010159:Palate / Q000196:embryology / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010766:Phosphorylation; D014059:Tongue / Q000196:embryology / Q000201:enzymology; D014070:Tooth / Q000196:embryology / Q000201:enzymology
D019869:Phosphatidylinositol 3-Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D051059:PTEN Phosphohydrolase