Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis.
Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.
Lefeuvre
Sandrine
S
INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur, 86000 Poitiers, France.
Marchand
Sandrine
S
Pariat
Claudine
C
Lamarche
Isabelle
I
Couet
William
W
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001202:Ascitic Fluid / Q000737:chemistry / Q000378:metabolism*; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D017551:Microdialysis; D010195:Pancreatitis / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D015378:Imipenem