title: From juvenile parkinsonism to encephalitis lethargica, a new phenotype of post-streptococcal disorders: case report.
abstract: We report the case of a 16-year-old boy presented with a mild akinetic-rigid parkinsonism shortly after a post-streptococcal infection. After stopping corticoids, he had a rapid neurological deterioration to a fatal encephalitis lethargica-like syndrome. Serum analysis demonstrated consistently elevated anti-streptolysin-O. This case illustrates a new severe phenotype in the spectrum of the post-streptococcal disorders. This etiology should be considered in the differential diagnosis of a movement disorder with a rapid detrimental evolution.
authors.affiliation: Department of Neurology, Hospital São Marcos, Largo Carlos Amarante, Apartado 2242, 4701-965 Braga, Portugal. beleza.76@gmail.com
authors.forename: Pedro
authors.initials: P
authors.lastname: Beleza
authors.forename: João
authors.initials: J
authors.lastname: Soares-Fernandes
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Jordão
authors.forename: Fátima
authors.initials: F
authors.lastname: Almeida
mesh_terms: D000293:Adolescent; D000405:Akinetic Mutism / Q000150:complications; D018450:Disease Progression; D006801:Humans; D018476:Hypokinesia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009127:Muscle Rigidity / Q000209:etiology; D010301:Parkinson Disease, Postencephalitic / Q000150:complications / Q000209:etiology* / Q000473:pathology; D020734:Parkinsonian Disorders / Q000150:complications / Q000209:etiology* / Q000473:pathology; D010641:Phenotype; D013290:Streptococcal Infections / Q000150:complications*