title: Category-specific semantic deficits in Alzheimer's disease: a semantic priming study.
abstract: Category-specific semantic deficits in individuals suffering brain damage after relatively focal lesions provide an important source of evidence about the organization of semantic knowledge. However, whether Alzheimer's disease (AD), in which the brain damage is more widespread, affects semantic categories to a different extent is still controversial. In the present study, we assess this issue by means of the semantic priming technique. AD patients with a mild impairment of their semantic knowledge showed comparable priming effects to that of controls for the categories of animals and artifacts. Interestingly, however, patients with a moderate impairment of their semantic knowledge showed a normal priming effect for animals but a very reduced priming effect (if any) for artifacts. These results reveal that AD may affect the semantic knowledge of different semantic categories to a different extent. The implications of this observation for current theoretical accounts of semantic representation in the brain are discussed.
authors.affiliation: GRNC, Parc Científic Universitat de Barcelona & Hospital Sant Joan de Déu, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Hernández
authors.forename: Albert
authors.initials: A
authors.lastname: Costa
authors.forename: Montserrat
authors.initials: M
authors.lastname: Juncadella
authors.forename: Núria
authors.initials: N
authors.lastname: Sebastián-Gallés
authors.forename: Ramón
authors.initials: R
authors.lastname: Reñé
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D001244:Association; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008568:Memory / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012660:Semantics; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis; D014705:Verbal Behavior / Q000502:physiology