[Markers and modulators of angiogenesis in ovarian cancer].
Understanding of the role played by angiogenesis in the growth of ovarian malignancies and an attempt to link this process with the clinical outcome of the disease call for an employment of reliable quantitative and qualitative measures--markers and modulators of angiogenesis. These tumor phenotypic qualities can be assessed with the use of immunohistochemical and immunoenzymatic assays, what reflects angiogenesis intensity, as well as its specific neoplastic properties. Supplementing clinical and histopathological data with the information on markers and modulators of angiogenesis enables a notable increase in the prognosic accuracy of the clinical outcome in ovarian cancer.
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I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Akademia Medyczna im. prof. Feliksa Skubiszewskiego w Lublinie. wbed@wp.pl
D014408:Biomarkers, Tumor / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000235:genetics*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics; D019699:Thrombospondins / Q000235:genetics
D014408:Biomarkers, Tumor; D019699:Thrombospondins; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor