title: Vertebroplasty in multiple myeloma: outcomes in a large patient series.
abstract: OBJECTIVE
  Despite the literature supporting the efficacy of vertebroplasty for treatment of osteoporotic vertebral compression fractures, few reports exist documenting its use in the treatment of compression fractures in multiple myeloma patients. Accordingly, we sought to characterize the imaging characteristics, clinical course, and outcomes in myeloma patients treated with vertebroplasty.
  
  
  METHODS
  We performed a retrospective review of clinical outcome data from 67 multiple myeloma patients treated with vertebroplasty since October 2000. Quantitative outcome data including the Roland Morris Disability Questionnaire (RDQ) and Visual Analog Scales for pain and qualitative outcome data (self-reported pain, mobility, and narcotic use) were collected preoperatively, immediately after vertebroplasty, and at 1 week, 1 month, 6 months, and 1 year after treatment.
  
  
  RESULTS
  Significant improvements in all of the outcome measures were observed postoperatively and throughout the duration of follow-up. Quantitative outcome measures (RDQ, analog pain scale 0-10, with rest and activity) improved by 11.0 (48%; P < .0001), 2.7 (25%; P < .001), and 5.3 (48%; P < .0001) points, respectively, with persistent improvement at 1 year (P < .01; P < .03; P < .001). Eighty-two percent and 89% of patients experienced a significant improvement in subjective rest pain and activity pain, respectively. Subjective scores achieved durable improvements, with 65% of patients requiring fewer narcotics after vertebroplasty and 70% having improved mobility.
  
  
  CONCLUSIONS
  Vertebroplasty provides significant and durable pain relief for patients with intractable spinal pain secondary to compression fractures resulting from multiple myeloma.
authors.affiliation: Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: McDonald
authors.forename: A T
authors.initials: AT
authors.lastname: Trout
authors.forename: L A
authors.initials: LA
authors.lastname: Gray
authors.forename: A
authors.initials: A
authors.lastname: Dispenzieri
authors.forename: K R
authors.initials: KR
authors.lastname: Thielen
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D005260:Female; D050815:Fractures, Compression / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D019904:Polymethyl Methacrylate / Q000008:administration & dosage; D016103:Spinal Fractures / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D054854:Vertebroplasty
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate