[Intestinal microbiota of individuals who suffered occupational accidents with biological materials and underwent antiretroviral prophylaxis].
The aim of this study was to evaluate the intestinal microbiota of individuals who had suffered occupational accidents and had received antiretrovirals. The study group consisted of 23 individuals between 18 and 45 years old, of whom 13 were blood donors and 10 had suffered occupational accidents. Intestinal microflora, anthropometry and laboratory tests were evaluated before, after and 30 days after discontinuation of the medication. Zidovudine plus lamivudine was used in association with nelfinavir for 70% of the individuals, with efavirenz for 20% and with ritonavir for 10%. Nutritional, diet, laboratory and intestinal microbiota abnormalities were analyzed at three times: M1, not more than two days after starting prophylaxis; M2, on the last day of prophylaxis; and M3, 30 days after ending prophylaxis. Nausea, vomiting and diarrhea were present in 50% at M2. Overweight in 70%, malnutrition and eutrophy in 10% of the individuals remained unchanged during the study. Transaminases, triglycerides and LDL-cholesterol because elevated at M2 and normalized 30 days after discontinuation of the medication. There were significant reductions in Lactobacillus, Bifidobacterium and Bacteroides at the three times. The use of antiretrovirals caused a significant impact on the individuals intestinal microbiota, without recovery after 30 days.
Souza
Micheli Evangelista de
ME
Departamento de Doenças Tropicais, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP.
Pereira
Paulo Câmara Marques
PC
D000062:Accidents, Occupational; D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001439:Bacteroides / Q000187:drug effects; D001644:Bifidobacterium / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006282:Health Personnel; D006801:Humans; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D007778:Lactobacillus / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D009784:Occupational Diseases / Q000517:prevention & control*; D011446:Prospective Studies; D013997:Time Factors
D019380:Anti-HIV Agents