Effects of CCR2 and CCRS polymorphisms on HIV-1 infection in Thai females.
Polymorphisms in CCR2 and CCR5 genes reportedly affect HIV-1 transmission and disease progression in HIV-1-infected individuals. In the study presented here, we examined the effects of CCR2 and CCR5 polymorphisms on HIV-1 transmission in 74 Thai females who were exposed to HIV but seronegative (ESN) and in 347 HIV-seropositive females. We found that the combination of 2 non-synonymous substitutions, CCR2 V64I and CCR5 G316A, tended to occur more frequently in ESN females (2 of 74) than in HIV-1 infected females (1 of 347) (P = 0.08). This suggested that non-synonymous substitution in the CCR5 gene also affects HIV-1 transmission in an Asian population in which the CCR5-Delta32 is very rare.
Wichukchinda
Nuanjun
N
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Nakayama
Emi E
EE
Rojanawiwat
Archawin
A
Pathipvanich
Panita
P
Auwanit
Wattana
W
Vongsheree
Suthon
S
Ariyoshi
Koya
K
Sawanpanyalert
Pathom
P
Shioda
Tatsuo
T
D000328:Adult; D000818:Animals; D002460:Cell Line; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000235:genetics* / Q000821:virology; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054390:Receptors, CCR2 / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*; D013785:Thailand
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5