title: Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease.
abstract: BACKGROUND
  Medial temporal lobe atrophy (MTA) is an early sign of Alzheimer's disease (AD). The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically.
  
  
  OBJECTIVE
  To investigate whether simple computed tomography (CT) linear measurements of the brain could be of value in AD workup.
  
  
  METHODS
  Fifty-nine healthy control subjects and 248 AD subjects were recruited. They were evaluated using a comprehensive clinical workup. A series of linear CT measurements were obtained from brain CT.
  
  
  RESULTS
  In discriminant analysis, the temporal horn ratio and the suprasellar cistern ratio were the atrophy factors that contributed most significantly to the diagnoses. Combined with other clinical factors (apolipoprotein E4 genotype), a correct AD classification of 90.2% was achieved.
  
  
  CONCLUSIONS
  CT linear measurements could be of value in the workup of AD patients, considering the inexpensiveness and availability of CT as well as the simplicity of linear measurements.
authors.affiliation: Division of Clinical Geriatrics, Department of NVS, Karolinska Institute, Stockholm, Sweden.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: E
authors.initials: E
authors.lastname: Londos
authors.forename: L
authors.initials: L
authors.lastname: Minthon
authors.forename: C
authors.initials: C
authors.lastname: Wattmo
authors.forename: Huaijun
authors.initials: H
authors.lastname: Liu
authors.forename: P
authors.initials: P
authors.lastname: Aspelin
authors.forename: L-O
authors.initials: LO
authors.lastname: Wahlund
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D001931:Brain Mapping / Q000379:methods; D003430:Cross-Sectional Studies; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values; D015203:Reproducibility of Results; D013702:Temporal Lobe / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data