title: Acute cytomegalovirus colitis presenting during primary HIV infection: an unusual case of an immune reconstitution inflammatory syndrome.
abstract: Severe ulcerous cytomegalovirus pancolitis developed during primary human immunodeficiency virus (HIV) infection in a patient who underwent early combination antiretroviral treatment. This massive inflammatory process led to acute colon perforation. Serological testing demonstrated cytomegalovirus reactivation. Severe immunosuppression caused by primary HIV infection resulted in cytomegalovirus colitis, and initiation of early combination antiretroviral therapy triggered an immune reconstitution inflammatory syndrome potentially leading to colonic perforation.
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland. Ulrich.vonboth@usz.ch
authors.forename: Ulrich
authors.initials: U
authors.lastname: von Both
authors.forename: Reto
authors.initials: R
authors.lastname: Laffer
authors.forename: Christina
authors.initials: C
authors.lastname: Grube
authors.forename: Walter
authors.initials: W
authors.lastname: Bossart
authors.forename: Ariana
authors.initials: A
authors.lastname: Gaspert
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D003092:Colitis / Q000150:complications / Q000821:virology*; D003586:Cytomegalovirus Infections; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications*; D007416:Intestinal Perforation; D008297:Male
chemical_list: D019380:Anti-HIV Agents