title: Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides.
abstract: Cyanidin and its glycosides (Cy and Cyg) have been indicated as promising candidates as dietary compounds with a potential role in human health. They are the largest class of water-soluble compounds in plants, where they are responsible for the brilliant color (red, orange, blue) of fruits and flowers. As natural compounds of several foods such as vegetables, fruits and red wines, they are estimated to be widely ingested by humans. This paper, basing on the data previously reviewed in 2002, focuses on the findings regarding human and animal studies on Cy and Cyg absorption and metabolism, antioxidant activity and biological properties, with particular attention to anticarcinogenic activity, vasoprotective, anti-inflammatory, anti-obesity and anti-diabetes effects. It is concluded that although Cy and Cyg bioavailability is low, further investigations are necessary because some important metabolites may still not have been identified. Literature data on antioxidant activity and biological properties, however, widely confirm Cy and Cyg as dietary compounds with a potential beneficial role in human health.
authors.affiliation: Dipartimento di Chimica Biologica, Chimica Medica e Biologia Molecolare, Università degli Studi, Viale Andrea Doria 6, 95125 Catania, Italy. fgalvano@unict.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Galvano
authors.forename: Luca
authors.initials: L
authors.lastname: La Fauci
authors.forename: Paola
authors.initials: P
authors.lastname: Vitaglione
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fogliano
authors.forename: Luca
authors.initials: L
authors.lastname: Vanella
authors.forename: Catherine
authors.initials: C
authors.lastname: Felgines
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000493:pharmacokinetics* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D001808:Blood Vessels / Q000187:drug effects; D035264:Flowers; D016166:Free Radical Scavengers / Q000493:pharmacokinetics / Q000494:pharmacology*; D005638:Fruit; D006027:Glycosides / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D014920:Wine
chemical_list: D000872:Anthocyanins; D000893:Anti-Inflammatory Agents; D019440:Anti-Obesity Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D006027:Glycosides; D007004:Hypoglycemic Agents; C017154:cyanidin