title: Triple antimicrobial therapy and acid suppression in dogs with chronic vomiting and gastric Helicobacter spp.
abstract: BACKGROUND
  Helicobacter pylori is a common cause of gastritis and peptic ulcers in humans. Many dogs, including those with gastritis and chronic vomiting, are infected with Helicobacter spp.
  
  
  OBJECTIVE
  Triple antimicrobial therapy will eradicate Helicobacter infection, improve gastritis, and reduce clinical signs. The addition of acid suppression medication will not improve results.
  
  
  METHODS
  Twenty-four pet dogs with chronic vomiting and gastric Helicobacter spp.
  
  
  METHODS
  Dogs were randomly assigned to triple antimicrobial therapy with or without famotidine. Gastroduodenoscopy was performed 4 weeks and 6 months after therapy. Helicobacter spp status was determined by histologic assessment of gastric mucosal biopsy specimens.
  
  
  RESULTS
  Eradication rates for each treatment were not significantly different and combined were 75 and 42.9% at 4 weeks and 6 months, respectively. A greater improvement in gastritis scores occurred in dogs that became Helicobacter spp negative. Overall, the frequency of vomiting was reduced by 86.4%, but there were no differences between treatments.
  
  
  CONCLUSIONS
  Eradication rates of Helicobacter spp with both treatments were not significantly different. Eradication rates at 6 months were modest, and more effective treatments should be developed. Acid suppression is not a necessary component of treatment protocols for dogs. Eradication of gastric Helicobacter spp was associated with improvement in gastritis scores. Dramatic reduction of the vomiting frequency occurred with both treatment protocols. Gastric Helicobacter spp may cause or contribute to chronic vomiting and gastritis in some dogs.
authors.affiliation: Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA. mleib@vt.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Leib
authors.forename: Robert B
authors.initials: RB
authors.lastname: Duncan
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Ward
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D015738:Famotidine / Q000627:therapeutic use; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*; D013272:Stomach Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D014839:Vomiting / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D005765:Gastrointestinal Agents; D009942:Organometallic Compounds; D012459:Salicylates; D008795:Metronidazole; D015738:Famotidine; C015715:bismuth subsalicylate; D000658:Amoxicillin; D001729:Bismuth