title: Non-racemic (scalemic) planar-chiral five-membered metallacycles: routes, means, and pitfalls in their synthesis and characterization.
abstract: This critical review provides a systematic classification of the synthetic routes to planar-chiral five-membered metallacycles into several routes, namely C-H bond activation, oxidative addition, transmetallation and optical resolution. As a characteristic of these bulk compounds is that they are synthesized as binary mixtures of enantiomers in proportions varying from the racemate to enantiopure, a review of absolute-configuration determination of the title planar-chiral scalemates is presented. This review is of interest to organic and organometallic synthetic chemists involved in asymmetric synthesis (97 references).
authors.affiliation: Laboratoire de Synthèses Métallo-induites, Institut de Chimie de Strasbourg, Université Louis Pasteur, 4 rue Blaise Pascal, F-67000 Strasbourg, France. djukic@chimie.u-strasbg.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Djukic
authors.forename: Akram
authors.initials: A
authors.lastname: Hijazi
authors.forename: Howard D
authors.initials: HD
authors.lastname: Flack
authors.forename: Gérald
authors.initials: G
authors.lastname: Bernardinelli
mesh_terms: D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000145:classification; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000145:classification; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D009942:Organometallic Compounds