Method for the development of topical medicinal aerosols using liquified hydrocarbon gas.
Low chain liquid hydrocarbons (LH) at room temperature and atmospheric pressure can be used to simulate the effect of gas hydrocarbons (GH) in aerosol systems without the need of using pressured flasks. Samples of different tetracycline formulations were tested with LH and GH in order to study their behaviour and physicochemical stability in the system. The results showed a similar behaviour between samples when LH or GH were used, suggesting the use of LH to simulate the effect of GH introduction in the system, as a useful predictive method for the development of pressured aerosol formulations without using pressured containers in early steps of the process, such as pre-formulation studies.
Caballero
F
F
Unit of Pharmaceutical Technology, Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Barcelona, Avda Joan XXIII s/n, 08028 Barcelona, Spain. fcaballero@ars-vitae.com
Foradada
M
M
Miñarro
M
M
Pérez-Lozano
P
P
García-Montoya
E
E
Ticó
J R
JR
Suñé-Negre
J M
JM
D000287:Administration, Topical; D000336:Aerosols / Q000008:administration & dosage / Q000737:chemistry*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005740:Gases; D006838:Hydrocarbons / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry; D012997:Solvents; D019155:Veterinary Drugs
D000336:Aerosols; D005740:Gases; D006838:Hydrocarbons; D012997:Solvents; D019155:Veterinary Drugs