title: Rhodium/chiral diene-catalyzed asymmetric 1,4-addition of arylboronic acids to arylmethylene cyanoacetates.
abstract: Asymmetric 1,4-addition of arylboronic acids to (E)-methyl 2-cyano-3-arylpropenoates proceeded in the presence of a rhodium catalyst (3 mol %) coordinated with a chiral diene ligand, (R,R)-Ph-bod*, to give high yields of the corresponding methyl 3,3-diaryl-2-cyanopropanoates with high enantioselectivity (up to 99% ee). This catalytic asymmetric transformation was applied to the asymmetric synthesis of (R)-tolterodine.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sörgel
authors.forename: Norihito
authors.initials: N
authors.lastname: Tokunaga
authors.forename: Keigo
authors.initials: K
authors.lastname: Sasaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi