title: Piper cubeba demonstrates anti-estrogenic and anti-inflammatory properties.
abstract: This present study aims to investigate if P9605, an ethanolic extract of PIPER CUBEBA L, exhibits anti-estrogenic and anti-inflammatory properties. We found that P9605 significantly inhibited growth induced by beta-estradiol in MCF-7, a human breast cancer cell line. It inhibited aromatase activity, which is responsible for transforming androgens into estrogens. Competitive binding assays also indicated P9605 binding to both human recombinant estrogen a and beta receptors. Furthermore, this extract inhibited the activities of cyclo-oxygenases (COX-1 and COX-2) and 5-lipo-oxygenase (5-LOX), also it attenuated the induction of interleukin 6 (IL-6) in differentiated THP-1 cells stimulated by lipopolysaccharide (LPS). Taken together with our previous results, P9605 possesses anti-androgenic, anti-estrogenic and anti-inflammatory properties. These results support the potential use of P9605 in phytotherapy against benign prostatic hyperplasia (BPH).
authors.affiliation: Department of Research and Clinical Pharmacology, University Hospital, Basel, Switzerland.
authors.forename: Jianying
authors.initials: J
authors.lastname: Yam
authors.forename: Alexei
authors.initials: A
authors.lastname: Schaab
authors.forename: Matthias
authors.initials: M
authors.lastname: Kreuter
authors.forename: Juergen
authors.initials: J
authors.lastname: Drewe
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001094:Arachidonate 5-Lipoxygenase / Q000187:drug effects / Q000378:metabolism; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D051545:Cyclooxygenase 1 / Q000187:drug effects / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007700:Kinetics; D017705:Lignans / Q000494:pharmacology; D031701:Piper; D010936:Plant Extracts / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D020847:Estrogen Receptor Modulators; D017705:Lignans; C527967:Piper cubeba extract; D010936:Plant Extracts; D001094:Arachidonate 5-Lipoxygenase; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D013936:Thymidine