title: [Effects of intracoronary transplantation of autologous bone marrow mononuclear cells or endothelial progenitor cells in mini-swine model of myocardial ischemia-reperfusion].
abstract: OBJECTIVE
  To compare the effects of intracoronary transplantation of autologous bone marrow mononuclear cells (BM-MNC) or peripheral endothelial progenitor cells (EPC) in mini-swine model of myocardial ischemia-reperfusion.
  
  
  METHODS
  The Mini-swine acute myocardial infarction and reperfusion model was created with 90 min occlusion of the left anterior descending coronary artery followed by reperfusion and the animals were then divided into BM-MNC group (3.54 x 10(8) +/- 0.90 x 10(8), n = 9), EPC group (1.16 x 10(7) +/- 1.07 x 10(7), n = 7) and control group (saline, n = 7). Echocardiography, hemodynamic measurements and myocardium infarction size were evaluated before and 4 weeks after intracoronary cell transplantations.
  
  
  RESULTS
  The net decrease from baseline to 4 weeks after transplantation of left ventricular ejection fraction (LVEF), left ventricular end systolic pressure, cardiac output and +dp/dt(max) were significantly attenuated post BM-MNC and EPC therapy compared to control group (all P < 0.05) and were similar between BM-MNC and EPC groups. Transplantation of BM-MNC and EPC also significantly decreased myocardial infarction size compared to control group.
  
  
  CONCLUSIONS
  Autologous intracoronary transplantation of BM-MNC or EPC in this model equally improved cardiac systolic function and reduced infarction area.
authors.affiliation: Coronary Heart Disease Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
authors.forename: Chong-jian
authors.initials: CJ
authors.lastname: Li
authors.forename: Run-lin
authors.initials: RL
authors.lastname: Gao
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
authors.forename: Feng-huan
authors.initials: FH
authors.lastname: Hu
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Yang
authors.forename: Lai-feng
authors.initials: LF
authors.lastname: Song
authors.forename: Ying-mao
authors.initials: YM
authors.lastname: Ruan
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Ji-lin
authors.initials: JL
authors.lastname: Chen
authors.forename: Xue-wen
authors.initials: XW
authors.lastname: Qin
authors.forename: Zai-jia
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D003326:Coronary Circulation; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000166:cytology; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology; D013552:Swine; D013556:Swine, Miniature; D014182:Transplantation, Autologous