Effects of modified amphotericin in experimental systemic candidiasis.
Lysosomotropic composition of dialdehyde dextran and amphotericin B had a greater therapeutic effect in mice with systemic candidiasis compared to free amphotericin B. This composition normalized glucocorticoid function of the adrenal glands and decreased the severity of liver destruction at late terms of granulomatous inflammation.
Shkurupy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. sck@soramn.ru
Selyatitskaya
V G
VG
Tsyrendorzhiev
D D
DD
Pal'chikova
N A
NA
Kurilin
V V
VV
Travin
M A
MA
Nadeev
A P
AP
Troitskii
A V
AV
D000666:Amphotericin B / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000209:etiology / Q000517:prevention & control; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000935:Antifungal Agents; D003911:Dextrans; C026948:dextran dialdehyde; D000666:Amphotericin B