[Changes in the aggregated lymphoid nodules and in the mesenterial lymph nodes of rats after the administration of a chemotherapeutic drug complex: response similarities and differences].
Changes in the structure and cellular composition of aggregated lymphoid nodules (ALN, Peyer's patches) of the small intestine and in mesenterial lymph nodes (MLN) were studied in 82 female Wistar rats 7, 14 and 21 days following a single intraperitoneal injection of a complex of antineoplastic drugs (cyclophosphamide, adriamycine, vincristine and prednisolone). In ALN and MLN lymphoid nodules the administration of antineoplastic drugs resulted in the decrease of the number of blast cells and mitotically dividing cells, suggesting the suppression of B-cell proliferation and differentiation. At the same time, the dimensions of germinal centers in ALN lymphoid nodules were reduced, while their mantle zone size remained unchanged. On the contrary, in MLN lymphoid nodules, mantle zone was reduced, while germinal center dimensions remained constant. Possible reasons of these differences in responses of the immune organs studied to chemotherapy, are discussed.
Maĭborodin
I V
IV
Strunkin
D N
DN
Maĭborodina
V I
VI
Kulikova
O V
OV
Lebedev
A A
AA
Zarubenkov
O A
OA
Cherenkova
M M
MM
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008643:Mesentery; D010581:Peyer's Patches / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D011239:Prednisolone / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone