Recent progress in pharmacological research of antioxidants in pathological conditions: cardiovascular health.
Antioxidants are essential, and are involved in several important biological processes such as immunity, protection against tissue damage, reproduction, growth and development. Antioxidants preserve adequate function of cells against homeostatic disturbances such as those caused by septic shock, aging and, in general, processes involving oxidative stress. Each year, many scientific articles are published describing the pharmacological and biological properties of antioxidants. This review article compiles recent findings on these properties, focusing mainly on the anti-inflammatory properties of antioxidants in different pathological areas, such as cardiovascular damage and sepsis. In relation to this process, this review focuses on the involvement of reactive oxygen and nitrogen species. Finally, the protective role of antioxidants against homeostatic disturbances such as those caused by endotoxin toxicity and cardiovascular damage, their potential clinical use, and the effects on the redox state of immune cells are discussed.
Victor
Victor M
VM
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Unidad Mixta CNIC-Universidad de Valencia (CNIC-UVEG), Departamento de Farmacologia, Facultad de Medicina, Avda. Blasco Ibañez 15, 46010 Valencia, Spain. vmvictor@cnic.es
McCreath
Kenneth J
KJ
Rocha
Milagros
M
D000975:Antioxidants / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005609:Free Radicals / Q000378:metabolism; D006262:Health; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D010330:Patents as Topic; D026361:Reactive Nitrogen Species / Q000378:metabolism / Q000502:physiology; D018805:Sepsis / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D008070:Lipopolysaccharides; D026361:Reactive Nitrogen Species; D009569:Nitric Oxide