title: [A novel anticancer drug delivery system -DAC-70/CDDP].
abstract: We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.
authors.affiliation: Dept. of Surgery, Iwate Medical University.
authors.forename: Akio
authors.initials: A
authors.lastname: Sugitachi
authors.forename: Koki
authors.initials: K
authors.lastname: Otsuka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Itabashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yoshimori
authors.initials: Y
authors.lastname: Takamori
authors.forename: Seiji
authors.initials: S
authors.lastname: Kurozumi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Mori
authors.forename: Go
authors.initials: G
authors.lastname: Wakabayashi
mesh_terms: D000107:Acetylation; D002686:Chitin / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry* / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism
chemical_list: D002686:Chitin; D002945:Cisplatin