The role of secretory IgA and complement in IgA nephropathy.
IgA nephropathy (IgAN) is characterized by glomerular deposition of IgA, often together with complement components. This deposited IgA is mainly polymeric in nature. Although early studies suggested a role for local complement activation in the development of glomerular injury in IgAN, recent attention has focused on the involvement of the lectin pathway of complement activation in the progression of renal disease in IgAN. In addition, we have found that glomerular secretory IgA deposition may be one of the initiators of local complement activation in the kidney. In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected.
Oortwijn
Beatrijs D
BD
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
Eijgenraam
Jan-Willem
JW
Rastaldi
Maria-Pia
MP
Roos
Anja
A
Daha
Mohamed R
MR
van Kooten
Cees
C
D003165:Complement System Proteins / Q000276:immunology*; D005753:Gastric Mucosa / Q000276:immunology; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000503:physiopathology; D006031:Glycosylation; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D037601:Mannose-Binding Lectin / Q000276:immunology
D007071:Immunoglobulin A, Secretory; D037601:Mannose-Binding Lectin; D003165:Complement System Proteins