title: A structural informatics study on collagen.
abstract: The study integrates knowledge resulting from structure-activity relationships analysis of amino acids with respect to the characterization of alpha1 and alpha2 type I collagen chains. Specifically, 15 amino acids and 14 properties were investigated and their structure-activity relationship models were obtained. The models were integrated into a web application and were used to predict the properties of a set of six amino acids. The similarities in alpha1 and alpha2 type I collagen chains has been investigated starting from the observed and predicted properties of amino acids by using two-step cluster analysis.
authors.forename: Sorana D
authors.initials: SD
authors.lastname: Bolboaca
authors.forename: Lorentz
authors.initials: L
authors.lastname: Jäntschi
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D024042:Collagen Type I / Q000737:chemistry*; D019295:Computational Biology / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D011487:Protein Conformation; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D024042:Collagen Type I