Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.
It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.
Need
Anna C
AC
Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA.
Attix
Deborah K
DK
McEvoy
Jill M
JM
Cirulli
Elizabeth T
ET
Linney
Kristen N
KN
Wagoner
Ana Patricia
AP
Gumbs
Curtis E
CE
Giegling
Ina
I
Möller
Hans-Jürgen
HJ
Francks
Clyde
C
Muglia
Pierandrea
P
Roses
Allen
A
Gibson
Greg
G
Weale
Mike E
ME
Rujescu
Dan
D
Goldstein
David B
DB
D015331:Cohort Studies; D005060:Europe; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008568:Memory / Q000502:physiology*; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D015203:Reproducibility of Results; D044465:White People
D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human