Synthesis and biological activity of chloroethyl pyrimidine nucleosides.
The synthesis and biological activity of chloroethyl pyrimidine nucleosides is presented. One of these new nucleosides analogues significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
Colombeau
Ludovic
L
Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Limoges, France.
Teste
Karine
K
Hadj-Bouazza
Amel
A
Chaleix
Vincent
V
Zerrouki
Rachida
R
Kraemer
Michel
M
Catherine
Odile Sainte
OS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014846:Vulvar Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D006843:Hydrocarbons, Chlorinated; D011741:Pyrimidine Nucleosides