Comparison of optic disc margin identified by color disc photography and high-speed ultrahigh-resolution optical coherence tomography.
OBJECTIVE
To determine the correspondence between optic disc margins evaluated using disc photography (DP) and optical coherence tomography (OCT).


METHODS
From May 1, 2005, through November 10, 2005, 17 healthy volunteers (17 eyes) had raster scans (180 frames, 501 samplings per frame) centered on the optic disc taken with stereo-optic DP and high-speed ultrahigh-resolution OCT (hsUHR-OCT). Two image outputs were derived from the hsUHR-OCT data set: an en face hsUHR-OCT fundus image and a set of 180 frames of cross-sectional images. Three ophthalmologists independently and in a masked, randomized fashion marked the disc margin on the DP, hsUHR-OCT fundus, and cross-sectional images using custom software. Disc size (area and horizontal and vertical diameters) and location of the geometric disc center were compared among the 3 types of images.


RESULTS
The hsUHR-OCT fundus image definition showed a significantly smaller disc size than the DP definition (P <.001, mixed-effects analysis). The hsUHR-OCT cross-sectional image definition showed a significantly larger disc size than the DP definition (P <.001). The geometric disc center location was similar among the 3 types of images except for the y-coordinate, which was significantly smaller in the hsUHR-OCT fundus images than in the DP images.


CONCLUSIONS
The optic disc margin as defined by hsUHR-OCT was significantly different than the margin defined by DP.
Manassakorn
Anita
A
UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ishikawa
Hiroshi
H
Kim
Jong S
JS
Wollstein
Gadi
G
Bilonick
Richard A
RA
Kagemann
Larry
L
Gabriele
Michelle L
ML
Sung
Kyung Rim
KR
Mumcuoglu
Tarkan
T
Duker
Jay S
JS
Fujimoto
James G
JG
Schuman
Joel S
JS
D000328:Adult; D019412:Anatomy, Cross-Sectional; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000033:anatomy & histology*; D010781:Photography / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*