[Repeating of emotional stress prevents development of melanocortin obesity and type 2 diabetes in the mice with the Agouti yellow mutation].
Brain melanocortin system (MC-system) participates in regulation of energy homeostasis. Dominant mutation yellow of the Agouti gene leads to the hyperphagia, obesity and type 2 diabetes. Stress is known to inhibit food intake and body weight. The aim of the work was to study effects of repeating emotional stress on food intake and lipid-carbohydrate metabolism in Ay-mice. Male mice of C57B1/6J strain predisposed to the obesity (Ay/a-genotype) and normal (a/a-genotype) were used. In control group food intake, body weight and blood levels of insulin and leptin were increased in Ay/a-mice as compared to a/a-mice. Repeating emotional stress (30 min restraint 3 times a week for 5 weeks) did not alter food intake and indices of lipid-carbohydrate metabolism in a/a-mice and decreased food intake, body weight and blood levels of insulin and leptin in Ay/a-mice. Insulin and leptin blood levels were the same in Ay/a- and a/a-mice on 5 week of treatment. The stress increased basal and stress-induced concentrations of corticosterone to an equal degree in Ay/a- and a/a-mice. Thus, light repeating emotional stress hampered development of obesity and 2 type diabetes in the mice with the Agouti yellow mutation.
Bazhan
N V
NV
Makarova
E N
EN
Shevchenko
A Iu
AIu
Iakovleva
T V
TV
D054366:Agouti Signaling Protein / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000235:genetics; D003345:Corticosterone / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics / Q000517:prevention & control; D004435:Eating / Q000235:genetics; D004734:Energy Metabolism / Q000235:genetics; D006963:Hyperphagia / Q000097:blood / Q000235:genetics; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000235:genetics; D053486:Melanocortins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009765:Obesity / Q000097:blood* / Q000235:genetics / Q000517:prevention & control; D013315:Stress, Psychological / Q000097:blood* / Q000235:genetics; D013997:Time Factors
D054366:Agouti Signaling Protein; D007328:Insulin; D020738:Leptin; D053486:Melanocortins; C515183:a protein, mouse; D003345:Corticosterone