title: A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation.
abstract: Cutaneous Epstein-Barr virus (EBV)-associated B-cell lymphoma (EBVBL) in non-immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72-year-old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B-cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern.
authors.affiliation: Department of Dermatology, Matsumoto National Hospital, Matsumoto, Japan. ytokuda@abeam.ocn.ne.jp
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Tokuda
authors.forename: Mana
authors.initials: M
authors.lastname: Fukushima
authors.forename: Koh
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Oguchi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Koganehira
authors.forename: Maki
authors.initials: M
authors.lastname: Yamaura
authors.forename: Miwako
authors.initials: M
authors.lastname: Iijima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murata
authors.forename: Hisashi
authors.initials: H
authors.lastname: Uhara
authors.forename: Minoru
authors.initials: M
authors.lastname: Takata
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Katsuyama
authors.forename: Sigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology*; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D007158:Immunologic Techniques; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014763:Viral Matrix Proteins / Q000032:analysis; D017735:Virus Latency
chemical_list: D015703:Antigens, CD; D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D012367:RNA, Viral; D014763:Viral Matrix Proteins