title: Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.
abstract: Five metabolites, ( Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3-methylsulfanylpiperazine-2,5-dione ( 1), (3S,3'R)-3-(3'-hydroxybutyl)-7-methoxyphthalide ( 2), ( S)-3-butyl-7-methoxyphthalide ( 3), (3R,6R)-bisdethiodi(methylthio)hyalodendrin ( 4), and bis- N-norgliovictin ( 5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1, 3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 microg/mL.
authors.affiliation: Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand.
authors.forename: Vilailak
authors.initials: V
authors.lastname: Prachyawarakorn
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Sanya
authors.initials: S
authors.lastname: Sureram
authors.forename: Suwannee
authors.initials: S
authors.lastname: Sangpetsiripan
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D054659:Diketopiperazines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005658:Fungi; D006801:Humans; D008517:Phytotherapy; D012623:Seawater
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D054659:Diketopiperazines; C082022:phthalide