No association of the POLI Thr706Ala polymorphism with the risk of cervical carcinoma.
OBJECTIVE
To investigate the association of repair gene POLI genetic polymorphisms with cervical carcinoma.


METHODS
Four hundred sixty one cervical carcinoma patients and 628 normal women were randomly selected for this study. Single nucleotide polymorphisms (SNPs) (POLI Thr706Ala) were genotyped, and the epidemiological risk factor was assessed.


RESULTS
Compared with the POLI Thr706Thr genotype, neither POLI Thr706Ala nor POLI Ala706Ala elevated or decreased the risk of cervical carcinoma or cervical squamous cell carcinoma [ORs and 95% CIs 1.25(0.97-1.61), 1.11(0.67-1.83), 1.22(0.94-1.58), 1.06(0.63-1.78), respectively]. When analyzing the risk of the POLI Thr706Ala variant genotype for cervical carcinoma in different histological types or HPV infection status, very similar risk factors were observed for the squamous cell carcinoma group or the HPV positive group to the overall carcinoma. Regardless of sexual or reproductive histories, patients with the POLI Thr706Ala or POLI Ala706Ala genotype showed a significantly increased risk of cervical carcinoma.


CONCLUSIONS
The POLI Thr706Ala genotype was not associated with cervical carcinoma in a Chinese population, but we cannot exclude the possibility that the POLI polymorphism might be associated with sexual and reproductive history.
Zhang
J
J
Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou, Zhejiang 310006, China. Electronic address: zhangjyy@hotmail.com.
Ye
F
F
Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou, Zhejiang 310006, China. Electronic address: yefyef@zju.edu.cn.
Cheng
Q
Q
Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou, Zhejiang 310006, China.
Shen
J
J
Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou, Zhejiang 310006, China.
Chen
H
H
Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou, Zhejiang 310006, China. Electronic address: chenhz@zju.edu.cn.
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D015751:Genes, pol / Q000235:genetics*; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*