title: Lipid-lowering drug use in Italian primary care: effects of reimbursement criteria revision.
abstract: OBJECTIVE
  To assess whether the prescribing pattern of lipid-lowering drugs (LLD) changed after reimbursement criteria revision in a general practice in southern Italy.
  
  
  METHODS
  From the Caserta-1 Local Health Service database, 93 general practitioners (GPs) who had consistently sent data about their patients during the years 2003-2005 were recruited. Prevalence of use and incidence of new treatments were calculated for each year, stratified by three drug cohorts: statins, omega-3 fatty acids, and fibrates. Subanalyses by gender, age, and indication of use were performed.
  
  
  RESULTS
  Overall, 1-year prevalence of LLD use increased from 2003 to 2004. After reimbursement criteria revision (November 2004), a slight decrease was observed for statins, from 41.1 (95% CI: 39.9-42.2) per 1,000 inhabitants in 2004 to 40.3 (39.2-41.5) in 2005, while omega-3 utilization fell markedly: 14.6 (13.9-15.3) vs. 5.4 (5.0-5.8). The use of both statins and omega-3 fatty acids was reduced particularly for primary prevention. On the other hand, utilization of statins increased in diabetic patients and as secondary prevention from 2004 to 2005. Concerning individual molecules, 1-year prevalence of use of any statin declined from 2004 to 2005, except for rosuvastatin.
  
  
  CONCLUSIONS
  Revision of reimbursement criteria led to significant changes in the trend in LLD use in general practice in southern Italy: (1) statin utilization was slightly reduced in 2005, although it increased in certain categories, such as diabetic patients, and (2) omega-3 fatty acid use was strongly reduced even though a higher use in postinfarction cases was reported.
authors.affiliation: Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy. trifirog@unime.it
authors.forename: G
authors.initials: G
authors.lastname: Trifirò
authors.forename: M
authors.initials: M
authors.lastname: Alacqua
authors.forename: S
authors.initials: S
authors.lastname: Corrao
authors.forename: S
authors.initials: S
authors.lastname: Moretti
authors.forename: D U
authors.initials: DU
authors.lastname: Tari
authors.forename: M
authors.initials: M
authors.lastname: Galdo
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
authors.forename: V
authors.initials: V
authors.lastname: Arcoraci
mesh_terms: D002994:Clofibrate / Q000627:therapeutic use; D004363:Drug Utilization; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007349:Insurance, Health, Reimbursement; D007558:Italy; D011320:Primary Health Care
chemical_list: D015525:Fatty Acids, Omega-3; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D002994:Clofibrate