[Abuse of anabolic steroids and its impact on thyroid function].
The use of anabolic steroids to increase physical performance and for aesthetic ends has reached alarming indices in the last three decades. Besides the desired actions, several collateral effects have been described in the literature, such as the development of some types of cancer, ginecomasty, peliosis hepatis, renal insufficiency, virilization, amongst others. The most proeminent effect on human thyroid function is the reduction of thyroxine binding globulin (TBG), with consequent reductions of total serum T3 and T4, depending however on the susceptibility of the drug to aromatization and subsequent transformation into estrogen. In rats, anabolic steroids also act in the peripheral metabolism of thyroid hormones and seem to exert an important proliferative effect on thyroid cells. Thus, the aim of the present paper is to review data on the effect of supraphysiological doses of anabolic steroids on thyroid function, showing the danger that indiscriminate use of these drugs can cause to health.
Fortunato
Rodrigo S
RS
Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ.
Rosenthal
Doris
D
Carvalho
Denise P de
DP
D045930:Anabolic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D004300:Doping in Sports; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood; D051381:Rats; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology; D013972:Thyrotropin / Q000502:physiology*
D045930:Anabolic Agents; D013963:Thyroid Hormones; D013972:Thyrotropin; D007453:Iodide Peroxidase