title: An angiographic evaluation of restenosis rate at a six-month follow-up of patients with ST-elevation myocardial infarction submitted to primary percutaneous coronary intervention.
abstract: BACKGROUND
  Percutaneous coronary intervention (PCI) is considered to be the optimal type of revascularization in patients with ST-segment elevation myocardial infarction (STEMI). However, the long-term effectiveness of this procedure can be reduced by restenosis. This investigation was aimed at a prospective evaluation, in a group of STEMI patients of "the real world" (not involved in randomised trials), of the angiographic restenosis rate at a 6-month follow-up, and at identifying the relationship between restenosis and the patients' characteristics.
  
  
  METHODS
  Our study population consisted of 123 patients with STEMI submitted to primary PCI to then undergo stress echocardiography 3 months after PCI and an angiographic evaluation at a 6-month follow-up.
  
  
  RESULTS
  a) In real life the restenosis rate is quite high (42.3%); b) no correlation was found between patients' clinical characteristics and restenosis; c) restenosis rate was higher in patients with bare metal stents than in those with drug-eluting stents (55.8% vs. 11.1%; p<0.001); in patients with longer stents (21.6+/-8.62 vs 18.1+/-6.34 mm, p=0.015) and when more than one stent was implanted. Moreover, a consistent number of patients showed restenosis though asymptomatic.
  
  
  CONCLUSIONS
  Our data suggest that primary PCI is associated with a high incidence of angiographic restenosis. No correlation was found between patients' clinical characteristics and restenosis. The length and the number of implanted stents seem to be associated with a more probable restenosis at six-month angiographic evaluation. Drug-eluting stent implantation seems to be associated with a lower incidence of restenosis even in STEMI patients.
authors.affiliation: Catheterisation Laboratory, Heart and Vessel Department, University of Florence, Florence, Italy. cristinagiglioli@yahoo.it
authors.forename: C
authors.initials: C
authors.lastname: Giglioli
authors.forename: S
authors.initials: S
authors.lastname: Valente
authors.forename: M
authors.initials: M
authors.lastname: Margheri
authors.forename: M
authors.initials: M
authors.lastname: Comeglio
authors.forename: M
authors.initials: M
authors.lastname: Chiostri
authors.forename: S M
authors.initials: SM
authors.lastname: Romano
authors.forename: E
authors.initials: E
authors.lastname: Saletti
authors.forename: M
authors.initials: M
authors.lastname: Falai
authors.forename: T
authors.initials: T
authors.lastname: Chechi
authors.forename: G F
authors.initials: GF
authors.lastname: Gensini
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D054855:Drug-Eluting Stents; D025401:Echocardiography, Stress; D004562:Electrocardiography; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008670:Metals; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D011446:Prospective Studies; D015607:Stents; D013997:Time Factors
chemical_list: D008670:Metals