Calcium signalling during the cleavage period of zebrafish development.
Imaging studies, using both luminescent and fluorescent Ca(2+)-sensitive reporters, have revealed that during the first few meroblastic cleavages of the large embryos of teleosts, localized elevations of intracellular Ca(2+) accompany positioning, propagation, deepening and apposition of the cleavage furrows. Here, we will review the Ca(2+) transients reported during the cleavage period in these embryos, with reference mainly to that of the zebrafish (Danio rerio). We will also present the latest findings that support the proposal that Ca(2+) transients are an essential feature of embryonic cytokinesis. In addition, the potential upstream triggers and downstream targets of the different cytokinetic Ca(2+) transients will be discussed. Finally, we will present a hypothetical model that summarizes what has been suggested to be the various roles of Ca(2+) signalling during cytokinesis in teleost embryos.
Webb
Sarah E
SE
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People's Republic of China.
Li
Wai Ming
WM
Miller
Andrew L
AL
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002970:Cleavage Stage, Ovum / Q000502:physiology*; D048749:Cytokinesis / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism
D002118:Calcium