title: NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events.
abstract: We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance.
authors.affiliation: Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. mail@g-pipa.de
authors.forename: Gordon
authors.initials: G
authors.lastname: Pipa
authors.forename: Diek W
authors.initials: DW
authors.lastname: Wheeler
authors.forename: Wolf
authors.initials: W
authors.lastname: Singer
authors.forename: Danko
authors.initials: D
authors.lastname: Nikolić
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D001683:Biological Clocks; D002415:Cats; D009474:Neurons / Q000502:physiology; D009482:Neurophysiology / Q000379:methods*; D018408:Patch-Clamp Techniques / Q000379:methods; D012984:Software; D018709:Statistics, Nonparametric; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology