title: Insight, quality of life, and functional capacity in middle-aged and older adults with schizophrenia.
abstract: OBJECTIVE
  The quality of life (QOL) for individuals with schizophrenia is determined by a number of factors, not limited to symptomatology. The current study examined lack of insight as one such factor that may influence subjective QOL or functional capacity. It was hypothesized that insight would significantly interact with symptom severity to influence subjective QOL. Insight was not expected to influence the relation between symptom severity and functional capacity.
  
  
  METHODS
  Participants were middle-aged and older outpatients who met diagnostic criteria for schizophrenia or schizoaffective disorder, and subsyndromal depression. Insight, psychopathology, and subjective QOL were assessed via semi-structured interviews and functional capacity was assessed via performance-based measures.
  
  
  RESULTS
  Insight interacts with negative symptom severity to predict subjective QOL. Severity of negative symptoms and insight contribute directly to functional capacity.
  
  
  CONCLUSIONS
  Individuals with intact insight may be better able to manage their symptoms, resulting in improved QOL. Treatment implications for improving the QOL of middle age and older adults with schizophrenia are discussed.
authors.affiliation: University of Texas MD Anderson Cancer Center, Houston, TX 77230-1439, USA. acsenior@hotmail.com
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Roseman
authors.forename: John
authors.initials: J
authors.lastname: Kasckow
authors.forename: Ian
authors.initials: I
authors.lastname: Fellows
authors.forename: Katerine
authors.initials: K
authors.lastname: Osatuke
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Patterson
authors.forename: Somaia
authors.initials: S
authors.lastname: Mohamed
authors.forename: Sidney
authors.initials: S
authors.lastname: Zisook
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011788:Quality of Life; D012559:Schizophrenia / Q000503:physiopathology* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D012649:Self Concept