title: Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol.
abstract: Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.
authors.affiliation: Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia.
authors.forename: Chelsea J
authors.initials: CJ
authors.lastname: Papadopoulos
authors.forename: Christine F
authors.initials: CF
authors.lastname: Carson
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Chang
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Riley
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D000081005:Cyclohexane Monoterpenes; D003511:Cyclohexanols / Q000737:chemistry / Q000494:pharmacology; D053138:Cyclohexenes / Q000737:chemistry / Q000494:pharmacology; D000077591:Eucalyptol; D031650:Melaleuca / Q000737:chemistry*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D020947:Tea Tree Oil / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D000081005:Cyclohexane Monoterpenes; D003511:Cyclohexanols; D053138:Cyclohexenes; D026901:Membrane Transport Proteins; C118598:MexA protein, Pseudomonas aeruginosa; C118597:MexB protein, Pseudomonas aeruginosa; D039821:Monoterpenes; C402263:OprM protein, Pseudomonas aeruginosa; C016775:alpha-terpineol; D020947:Tea Tree Oil; D000077591:Eucalyptol