Drug-resistant malaria parasites introduced into Madagascar from Comoros Islands.
To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers. For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high. International-level antimalarial policy and a regional antimalarial forum are needed.
Ménard
Didier
D
Institut Pasteur de Madagascar, Antananarivo, Madagascar. dmenard@pasteur.mg
Randrianarivo-Solofoniaina
Armand Eugène
AE
Ahmed
Bedja Said
BS
Jahevitra
Martial
M
Andriantsoanirina
Valérie
V
Rasolofomanana
Justin Ranjalahy
JR
Rabarijaona
Léon Paul
LP
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D017507:Comoros / Q000453:epidemiology; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D011739:Pyrimethamine / Q000627:therapeutic use; D014195:Travel
D000962:Antimalarials; D002738:Chloroquine; D011739:Pyrimethamine