Cannabinoids for cancer treatment: progress and promise.
Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work that raises interest in the development and exploration of potent, nontoxic, and nonhabit forming cannabinoids for cancer therapy.
Sarfaraz
Sami
S
Chemoprevention Program, Paul P. Carbone Comprehensive Cancer Center and Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA.
Adhami
Vaqar M
VM
Syed
Deeba N
DN
Afaq
Farrukh
F
Mukhtar
Hasan
H
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy; D002186:Cannabinoids / Q000145:classification / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism / Q000502:physiology; D012878:Skin Neoplasms / Q000188:drug therapy
D002186:Cannabinoids; D043882:Receptors, Cannabinoid