Potential biomarkers of ageing.
Life span in individual humans is very heterogeneous.Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases,could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation,inflammation, cellular senescence and hormonal deregulation are discussed.
Simm
Andreas
A
Department of Cardiothoracic Surgery, Martin LutherUniversity Halle-Wittenberg, Ernst-Grube Str. 40,D-06120 Halle, Germany. andreas.simm@medizin.uni-halle.de
Nass
Norbert
N
Bartling
Babett
B
Hofmann
Britt
B
Silber
Rolf-Edgar
RE
Navarrete Santos
Alexander
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers; D016922:Cellular Senescence / Q000502:physiology; D003687:Dehydroepiandrosterone / Q000502:physiology; D004967:Estrogens / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007328:Insulin / Q000502:physiology; D015416:Maillard Reaction; D018384:Oxidative Stress / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D016615:Telomere / Q000502:physiology; D013739:Testosterone / Q000502:physiology
D015415:Biomarkers; D004967:Estrogens; D007328:Insulin; D011506:Proteins; D013739:Testosterone; D003687:Dehydroepiandrosterone; D013006:Growth Hormone