Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion.
Novel reactions that can selectively functionalize carbon-hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon-hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C-H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C-H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.
Davies
Huw M L
HM
Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York 14260-3000, USA. hdavies@buffalo.edu
Manning
James R
JR
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006838:Hydrocarbons / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry
D001688:Biological Products; D006838:Hydrocarbons; D004364:Pharmaceutical Preparations; D002244:Carbon; D006859:Hydrogen