title: [Severe herpetic infection].
abstract: OBJECTIVE
  To study antiviral defense in patients with severe anogenital and labial herpetic infection, prevalence of herpetic infection and possible combination with other strains.
  
  
  METHODS
  The immune status (basic lymphocyte subpopulations, IgA, IgM, IgG, circulating immune complexes in blood serum, cytokines, interferon status, functional activity of neutrophils) was investigated in 102 patients with severe Herpex simplex infection (HSI).
  
  
  RESULTS
  Marked deficiency and hyporeactivity of natural and/or specific cytotoxicity were found in 70% HSI patients with severe disease.
  
  
  CONCLUSIONS
  Severe HSI runs in serious combined secondary immunodeficiency, its complications and is an active mixed viral infection.
authors.forename: N A
authors.initials: NA
authors.lastname: Didkovskiĭ
authors.forename: I K
authors.initials: IK
authors.lastname: Malashnkova
authors.forename: A N
authors.initials: AN
authors.lastname: Tanasova
authors.forename: I A
authors.initials: IA
authors.lastname: Zuĭkov
authors.forename: N M
authors.initials: NM
authors.lastname: Khitrik
authors.forename: Zh Sh
authors.initials: ZhSh
authors.lastname: Sarsaniia
mesh_terms: D000328:Adult; D005260:Female; D052776:Female Urogenital Diseases / Q000821:virology*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D052801:Male Urogenital Diseases / Q000821:virology*; D012002:Rectal Diseases / Q000821:virology; D012008:Recurrence
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007155:Immunologic Factors