[Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
OBJECTIVE
The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.


METHODS
The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses. Out of 40 patients included in the study, 25 underwent laparoscopy and 15 underwent laparotomy. Serum concentrations of TNF-alpha were measured by commercially available ELISA assays before the surgery and 4, 24 and 48 hours after the start of the operation.


RESULTS
A decrease of TNF-alpha serum concentrations was observed in the early postoperative period. 24 h after the operation concentrations of TNF-alpha were significantly higher in the laparotomy group as opposed to the group operated by laparoscopy.


CONCLUSIONS
Lower concentrations of TNF-alpha in the laparoscopy group, observed 24 hours after the operation, may reflect more favorable changes in the systemic inflammatory response after minimally invasive management of benign ovarian masses.
Torres
Anna
A
Katedra i Klinika Ginekologii Akademii Medycznej w Lublinie. anna.torres@am.lublin.pl
Torres
Kamil
K
Paszkowski
Tomasz
T
Staśkiewicz
Grzegorz
G
Maciejewski
Ryszard
R
Woźniakowska
Ewa
E
Zaleska
Wacława
W
D000291:Adnexal Diseases / Q000097:blood / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007813:Laparotomy; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D011184:Postoperative Period; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D014408:Biomarkers, Tumor; D014409:Tumor Necrosis Factor-alpha