Homicidal ideation with intent during a manic episode triggered by antidepressant medication in a man with brain injury.
BACKGROUND
Mood disorders are more frequent after brain injury and both depressive and manic episodes are associated in these patients with an increased risk of aggression. Antidepressant medications are associated with a risk of manic induction.


METHODS
We describe a case of homicidal ideation with intent during the onset of a manic episode in a patient with prior brain injury on antidepressant medication at low dosage. The manic episode could have been secondary to brain injury and/or triggered by antidepressant medications. This case raises the possibility of the sensitizing role of brain injury for antidepressant-induced mania.


CONCLUSIONS
Further studies are needed to assess the role of brain injury as a risk factor for antidepressant-induced mania. Physicians should be cautious when prescribing antidepressants to patients with prior brain injury and inform them and their relatives of the possibility of a switch into mania.
Dealberto
Marie-José
MJ
Department of Psychiatry, Ottawa Hospital, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. dealbert@uottawa.ca
Marino
Josie
J
Bourgon
Luc
L
D000928:Antidepressive Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D013406:Suicide, Attempted / Q000523:psychology*
D000928:Antidepressive Agents