title: Explaining patients' beliefs about the necessity and harmfulness of antidepressants.
abstract: OBJECTIVE
  Patients' beliefs about antidepressants vary widely and probably influence adherence, yet little is known about what underlies such beliefs. This study's objective was to identify the demographic and clinical characteristics that account for patients' beliefs about antidepressants.
  
  
  METHODS
  Participants were 165 patients with unipolar nonpsychotic major depression from primary care and psychiatry clinics who were participating in the baseline phase of a multistaged trial of medication and psychotherapy. Before patients started antidepressants, interview and self-report measures were used to assess treatment beliefs, depression features, and comorbid conditions. Linear multivariate regression was used to identify the strongest correlates of perceived medication necessity and harmfulness after adjusting for age, sex, education, and the random effects of patients within clinical site.
  
  
  RESULTS
  Perceived necessity was associated with older age (P <.001), more severe symptoms (P = .03), longer anticipated duration of symptoms (P=.001), and attribution of symptoms to chemical imbalance (P=.005). Perceived harmfulness was highest among patients who had not taken antidepressants before (P = .02), attributed their symptoms to random factors (P=.04), and had a subjectively unclear understanding of depression (P = .003). Neither belief was significantly associated with sex, education, age at first depressive episode, presence of melancholia or anxiety, psychiatric comorbidity, or clinical setting.
  
  
  CONCLUSIONS
  Skepticism about antidepressants is strongest among younger patients who have never taken antidepressants, view their symptoms as mild and transient, and feel unclear about the factors affecting their depression. Perhaps these patients would benefit the most from adherence promotion focusing on treatment beliefs.
authors.affiliation: Department of Family Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. aikensj@umich.edu
authors.forename: James E
authors.initials: JE
authors.lastname: Aikens
authors.forename: Donald E
authors.initials: DE
authors.lastname: Nease
authors.forename: Michael S
authors.initials: MS
authors.lastname: Klinkman
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use; D003155:Community Mental Health Centers; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007407:Interviews as Topic; D016014:Linear Models; D008297:Male; D008824:Michigan; D015337:Multicenter Studies as Topic; D010349:Patient Compliance / Q000523:psychology*; D011320:Primary Health Care; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D016312:Treatment Refusal / Q000523:psychology*
chemical_list: D000928:Antidepressive Agents