Retromer retrieves wntless.
Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.
Eaton
Suzanne
S
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse-108, Dresden 01307, Germany. eaton@mpi-cbg.de
D000818:Animals; D011992:Endosomes / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D022161:Transport Vesicles / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D021601:trans-Golgi Network / Q000502:physiology*
D033921:Vesicular Transport Proteins; D051153:Wnt Proteins