Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?
For most patients with head and neck squamous cell cancer, a treatment decision concerning the neck is required. Since detection of small metastases in lymph nodes is difficult, many of the patients with no detectable metastases receive elective treatment of the neck. Additional information on the metastatic potential of the primary tumor before treatment may be useful to reduce the number of these elective procedures. Biomarkers may supply such information. Molecules involved in several pathways have been studied, but the complexity of the metastatic process makes it unlikely that a single marker for metastasis can de identified. Techniques allowing the study of many factors simultaneously seem to be the most promising ones. In recent years, microarray expression profiling and comparative genomic hybridization studies have yielded interesting results. If these results can be confirmed in larger studies, they may play a role in future clinical decision making on treatment of the clinically N0 neck.
Takes
Robert P
RP
Department of Otolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. r.takes@kno.umcn.nl
Rinaldo
Alessandra
A
Rodrigo
Juan Pablo
JP
Devaney
Kenneth O
KO
Fagan
Johannes J
JJ
Ferlito
Alfio
A
D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002468:Cell Physiological Phenomena; D018925:Chemokines / Q000378:metabolism; D003657:Decision Making; D005821:Genetic Techniques; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D037981:Neck Dissection; D009389:Neovascularization, Pathologic; D011003:Ploidies; D019707:Receptors, Chemokine / Q000378:metabolism
D014408:Biomarkers, Tumor; D018925:Chemokines; D019707:Receptors, Chemokine; D020782:Matrix Metalloproteinases