title: Copper-catalyzed coupling of hydroxylamines with aryl iodides.
abstract: An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
authors.affiliation: School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, United Kingdom.
authors.forename: Kerri L
authors.initials: KL
authors.lastname: Jones
authors.forename: Achim
authors.initials: A
authors.lastname: Porzelle
authors.forename: Adrian
authors.initials: A
authors.lastname: Hall
authors.forename: Michael D
authors.initials: MD
authors.lastname: Woodrow
authors.forename: Nicholas C O
authors.initials: NC
authors.lastname: Tomkinson
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006847:Hydrocarbons, Iodinated; D006898:Hydroxylamines; D003300:Copper