title: Possible role of extracellular signal-regulated kinase pathway in regulation of Sox9 mRNA expression in chondrocytes under hydrostatic pressure.
abstract: The potential involvement of the extracellular signal-regulated kinase (ERK) pathway in chondrocyte mechanotransduction was tested in bovine chondrocyte-agarose constructs under hydrostatic loading. Results suggested that the ERK pathway may be inhibited by hydrostatic pressure-induced mechanotransduction and may also be a negative regulator of Sox9 mRNA expression, which is an important modulator of chondrocyte function.
authors.affiliation: Academic Unit of Musculo-Skeletal and Rehabilitation Medicine, Bioengineering Division, University of Leeds, Leeds, LS2 9NZ, UK. ken-mio@muh.biglobe.ne.jp
authors.forename: Kensuke
authors.initials: K
authors.lastname: Mio
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kirkham
authors.forename: William A
authors.initials: WA
authors.lastname: Bonass
mesh_terms: D000818:Animals; D002417:Cattle; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D019902:Chondrocytes / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D011312:Pressure; D012333:RNA, Messenger / Q000378:metabolism; D055758:SOX9 Transcription Factor; D023822:Tissue Engineering / Q000379:methods*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D006609:High Mobility Group Proteins; D012333:RNA, Messenger; D055758:SOX9 Transcription Factor; D014157:Transcription Factors; D048049:Extracellular Signal-Regulated MAP Kinases