[A novel anticancer drug delivery system -DAC-70/CDDP].
We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.
Sugitachi
Akio
A
Dept. of Surgery, Iwate Medical University.
Otsuka
Koki
K
Fujisawa
Kentaro
K
Itabashi
Tetsuya
T
Akiyama
Yuji
Y
Sasaki
Akira
A
Ikeda
Kenichiro
K
Yoshida
Yasuo
Y
Takamori
Yoshimori
Y
Kurozumi
Seiji
S
Mori
Takatoshi
T
Wakabayashi
Go
G
D000107:Acetylation; D002686:Chitin / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry* / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism
D002686:Chitin; D002945:Cisplatin