title: Early experience with intraoperative radiotherapy in patients with resected pancreatic adenocarcinoma.
abstract: BACKGROUND
  The use of intraoperative radiotherapy (IORT) in patients with resected pancreatic adenocarcinoma has not been clearly defined.
  
  
  METHODS
  The medical records of our first 22 patients receiving IORT for resected pancreatic adenocarcinoma (2001 to 2006) were reviewed and compared with the records of 27 consecutive patients not receiving IORT for resected pancreatic adenocarcinoma (2004 to 2006).
  
  
  RESULTS
  There were no 30-day mortalities in either group, and complication rates were similar. Local recurrence occurred in 18% in the IORT group (median 14 months) and 12% in the no-IORT group (median 7 months). Distant recurrence occurred in 47% in the IORT group (median 11 months) and 32% in the no-IORT group (median 6.5 months). Median overall, stage-specific, and location-specific survival did not differ between the groups.
  
  
  CONCLUSIONS
  Although limited in size and follow-up, our experience showed that complications, recurrence, and survival were not affected by IORT, but time to recurrence may be longer with IORT.
authors.affiliation: Department of Surgery, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106-5047, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Messick
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hardacre
authors.forename: Michael F
authors.initials: MF
authors.lastname: McGee
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Siegel
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Stellato
authors.forename: Juan R
authors.initials: JR
authors.lastname: Sanabria
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kinsella
authors.forename: James A
authors.initials: JA
authors.lastname: Schulak
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies