Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach.
Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.
Salvioli
Stefano
S
Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.
Capri
Miriam
M
Tieri
Paolo
P
Loroni
Jonathan
J
Barbi
Cristiana
C
Invidia
Laura
L
Altilia
Serena
S
Santoro
Aurelia
A
Pirazzini
Chiara
C
Pierini
Michela
M
Bellavista
Elena
E
Alberghina
Lilia
L
Franceschi
Claudio
C
D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D013997:Time Factors