Effective and efficient sensitisation of terbium luminescence at 355 nm with cell permeable pyrazoyl-1-azaxanthone macrocyclic complexes.
Emissive terbium complexes, suitable for protein conjugation, incorporating a pyrazoyl-1-aza-xanthone chromophore have been prepared; they exhibit cellular uptake and possess a much lower sensitivity to excited state quenching.
Montgomery
Craig P
CP
Department of Chemistry, Durham University, South Road, Durham, UK.
Parker
David
D
Lamarque
Laurent
L
D000818:Animals; D016466:CHO Cells; D002463:Cell Membrane Permeability / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D008024:Ligands; D049449:Luminescence; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D011720:Pyrazoles / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry*
D008024:Ligands; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D011720:Pyrazoles; D012709:Serum Albumin; D044004:Xanthones; D013725:Terbium