[Adenosine receptor--relation to dopaminergic system].
Adenosine is produced by conversion of intra- and extracellular adenine nucleotides, and plays a role as an endogenous modulator of synaptic functions in the central nervous system. The adenosine A2A receptors (A2AR) are enriched in dopamine-rich areas of the brain, such as the basal ganglia, and are thought to interact with dopamine D2 receptor (D2R) negatively. Selective A2AR antagonists have attracted attention as the treatment of Parkinson's disease (PD). Little information was available about the receptor in the living human brain until quite recently. However, we developed a PET ligand, [7-methyl-11C]-(E)-8- (3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C] TMSX), for mapping the A2AR. We reported that the binding potential (BP) of [11C]TMSX in normal human brain was the largest in the putamen, and was small in the cerebral cortex. Next, we investigated the relationship between A2AR in the drug naive PD. We found that the BP of [11C]TMSX was significantly lower on the more affected side than the less affected side of the putamen in PD patients. Release of dopamine is reduced asymmetrically in the putamen of early PD, and D2R are up-regulated as compensation for the decrease of dopamine. Our data showed that reaction of the A2AR was opposite to the D2R.
Mishina
Masahiro
M
Neurological Institute, Nippon Medical School Chiba Hokusoh Hospital.
Ishii
Kenji
K
Ishiwata
Kiichi
K
D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D011699:Putamen / Q000503:physiopathology; D043705:Receptor, Adenosine A2A / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*
D043705:Receptor, Adenosine A2A; D017448:Receptors, Dopamine D2