title: Biochemical abnormalities observed in serum of dogs infected with large Babesia in Warsaw (Poland).
abstract: Biochemical abnormalities observed in canine babesiosis are related to the severity of the disease. The primary biochemical abnormalities found in affected dogs are: increase of the serum activity of transaminases and alkaline phosphatase, azotemia, and hypoglycemia. The purposes of this study were: 1) to estimate biochemical abnormalities in dogs infected with large Babesia in Warsaw and 2) to evaluate statistically changes observed during canine babesiosis in dogs from Warsaw. Samples of serum were collected from dogs naturally infected with large Babesia. Among 2023 positive samples, 202 were randomly selected. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine, blood urea nitrogen (BUN), total serum protein (TSP), albumin and blood glucose concentration were determined with a clinical chemistry analyser. Elevated activity of ALT, AST and ALP was detected accordingly in: 64.9, 92.6 and 31.7% of dogs. Elevated creatinine concentration and BUN were detected accordingly in 30.7 and 62.4% of dogs. Decrease of TSP, albumin, BUN, and hypoglycemia was detected accordingly in: 19.8, 32.7, 1.5 and 18.3% of dogs. The most common biochemical abnormalities found in affected dogs were: increase of activity of transaminases and ALP, elevated creatinine concentration, hypoalbuminemia and hypoglycemia. These abnormalities resulted from hepatopathy, renal failure and fasting.
authors.affiliation: Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Ciszewskiego 8, 02-786 Warsaw, Poland. wojciechzygner@yahoo.pl
authors.forename: W
authors.initials: W
authors.lastname: Zygner
authors.forename: G
authors.initials: G
authors.lastname: Rapacka
authors.forename: O
authors.initials: O
authors.lastname: Gójska-Zygner
authors.forename: E
authors.initials: E
authors.lastname: Długosz
authors.forename: H
authors.initials: H
authors.lastname: Wedrychowicz
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001403:Babesia / Q000302:isolation & purification*; D001404:Babesiosis / Q000097:blood / Q000662:veterinary*; D001786:Blood Glucose; D001798:Blood Proteins; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D011044:Poland; D012709:Serum Albumin / Q000378:metabolism; D000075462:Serum Albumin, Human
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D012709:Serum Albumin; C402606:albumin Amsterdam; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000075462:Serum Albumin, Human