title: Investigations of CHD1 function in transcription and development of Drosophila melanogaster.
abstract: In this report we describe chd1 mutant alleles and show that the CHD1 chromatin-remodeling factor is important for wing development and fertility. While CHD1 colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes, elongating Pol II can persist on chromatin in the absence of CHD1. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function.
authors.affiliation: Joint Science Department, W. M. Keck Science Center, Scripps, Claremont McKenna, and Pitzer Colleges, Claremont, California 91711, USA.
authors.forename: Ivy E
authors.initials: IE
authors.lastname: McDaniel
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Lee
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Berger
authors.forename: Cori K
authors.initials: CK
authors.lastname: Hanagami
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Armstrong
mesh_terms: D000483:Alleles; D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics* / Q000254:growth & development*; D005260:Female; D005298:Fertility; D020043:Genes, Essential; D018398:Homeodomain Proteins / Q000378:metabolism; D008297:Male; D009154:Mutation / Q000235:genetics; D009866:Oogenesis; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D014921:Wings, Animal / Q000002:abnormalities / Q000254:growth & development
chemical_list: C100593:CHD1 protein, Drosophila; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D004265:DNA Helicases; C118474:kis protein, Drosophila