title: Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.
abstract: Obstructive sleep apnea (OSA) is associated with increased cardiovascular mortality, and oxidative stress was suggested to play an important role. We hypothesized that the plasma TRX level, a novel oxidative stress marker, is elevated in OSA patients. Plasma TRX and adiponectin levels, which are significantly associated with cardiovascular mortality, were measured in 41 patients with severe OSA before (n = 41) and after (n = 27) nasal continuous positive airway pressure therapy (nCPAP) for 1 month and in 12 subjects without OSA (non-OSA group). The TRX level was significantly higher (p = 0.02) and the adiponectin level was significantly lower (p = 0.02) in the OSA group than in the non-OSA group. After 1 month of nCPAP (n = 27), the TRX level significantly decreased (p = 0.03), and the adiponectin level significantly increased (p = 0.03). Among the 14 patients with untreated OSA, the TRX and adiponectin levels did not significantly change over a 1-month interval. Among the 53 (41 OSA + 12 non-OSA) subjects, the TRX level was positively correlated with the respiratory disturbance index (p = 0.001) and percentage of time with SaO(2) <90% (p = 0.0002). The adiponectin level, but not the TRX level, was correlated with the BMI (n = 53; p = 0.02). Plasma TRX may be a unique marker for evaluating oxidative stress and monitoring the effectiveness of nCPAP in OSA patients.
authors.affiliation: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chin
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
authors.forename: Kensuke
authors.initials: K
authors.lastname: Sumi
authors.forename: Toru
authors.initials: T
authors.lastname: Oga
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuhara
authors.forename: Junji
authors.initials: J
authors.lastname: Yodoi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*; D013879:Thioredoxins / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D013879:Thioredoxins; D002097:C-Reactive Protein