title: Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis.
abstract: BACKGROUND
  A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial - ankle pulse wave velocity and blood pressure.
  
  
  RESULTS
  In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima - media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A(1c) and total HCY, as well as CIMT.
  
  
  CONCLUSIONS
  CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it.
authors.affiliation: Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Usa
authors.forename: Mio
authors.initials: M
authors.lastname: Nakazato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Wada
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Nakashima
authors.forename: Koh
authors.initials: K
authors.lastname: Abe
authors.forename: Fuminao
authors.initials: F
authors.lastname: Takeshima
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ozono
mesh_terms: D000367:Age Factors; D000368:Aged; D000842:Ankle / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001837:Body Weights and Measures; D002784:Cholesterol / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011674:Pulse; D012737:Sex Factors; D017539:Tunica Intima / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D002784:Cholesterol; D006442:Glycated Hemoglobin; D006710:Homocysteine; C517652:hemoglobin A1c protein, human