title: Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light.
abstract: The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (.OH, O2. -, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda>455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jańczyk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wolnicka-Głubisz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Urbanska
authors.forename: Horst
authors.initials: H
authors.lastname: Kisch
authors.forename: Grazyna
authors.initials: G
authors.lastname: Stochel
authors.forename: Wojciech
authors.initials: W
authors.lastname: Macyk
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D008027:Light; D051379:Mice; D009336:Necrosis / Q000378:metabolism; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017671:Platinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D019097:Spin Trapping; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents; D017671:Platinum Compounds; D017382:Reactive Oxygen Species; C030173:platinum chloride; C009495:titanium dioxide; D014025:Titanium