title: Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry.
abstract: This study reports on the uptake of (99m)Tc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC).
  
  
  METHODS
  Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant bone-mestastasized breast carcinoma underwent (99m)Tc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive.
  
  
  RESULTS
  The uptake of (99m)Tc-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. (99m)Tc-RP527 uptake was not found in any of the tamoxifen-resistant patients.
  
  
  CONCLUSIONS
  Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.
authors.affiliation: Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. christophe.vandewiele@ugent.be
authors.forename: Christophe
authors.initials: C
authors.lastname: Van de Wiele
authors.forename: Philippe
authors.initials: P
authors.lastname: Phonteyne
authors.forename: Patrick
authors.initials: P
authors.lastname: Pauwels
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Goethals
authors.forename: Rudi
authors.initials: R
authors.lastname: Van den Broecke
authors.forename: Veronique
authors.initials: V
authors.lastname: Cocquyt
authors.forename: Rudi Andre
authors.initials: RA
authors.lastname: Dierckx
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009842:Oligopeptides / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018004:Receptors, Bombesin / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; C420883:technetium Tc 99m RP527