title: Oncolytic measles virus strains in the treatment of gliomas.
abstract: BACKGROUND
  Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy.
  
  
  OBJECTIVE
  In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas.
  
  
  METHODS
  Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described.
  
  
  CONCLUSIONS
  Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.
authors.affiliation: Mayo Clinic, Molecular Medicine Department, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Allen
authors.forename: Georgia
authors.initials: G
authors.lastname: Paraskevakou
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Liu
authors.forename: Ianko D
authors.initials: ID
authors.lastname: Iankov
authors.forename: Pavlos
authors.initials: P
authors.lastname: Msaouel
authors.forename: Paula
authors.initials: P
authors.lastname: Zollman
authors.forename: Rae
authors.initials: R
authors.lastname: Myers
authors.forename: Kah Whye
authors.initials: KW
authors.lastname: Peng
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Russell
authors.forename: Evanthia
authors.initials: E
authors.lastname: Galanis
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D005910:Glioma / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008458:Measles Vaccine / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D008459:Measles virus / Q000235:genetics / Q000276:immunology*; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D008458:Measles Vaccine