title: Postprocedural high-density lipoprotein cholesterol predicts carotid stent patency at 1 year.
abstract: The durability of carotid artery stenting (CAS) is affected by the occurrence of myointimal proliferation and in-stent restenosis (ISR). We aimed to identify clinical, angiographic, and laboratory predictors of ISR, paying special attention to postprocedural metabolic factors. A total of 102 consecutive patients with successful CAS for > or =70% atherosclerotic internal carotid artery stenosis were followed up with neurological assessment and duplex sonography 1 day, 1 month, and 1 year after CAS. Lipid profile and hemoglobin A(1c) were tested at the 1-month follow-up visit. Ten (10%) patients had ISR > or =50% after 1 year. Compared with patients without ISR (n = 92), patients with ISR were more often current smokers (33% vs. 70%, P = 0.034) and had significantly lower 1-month high-density lipoprotein (HDL) cholesterol: median (range) 47 (24-95) mg/dl vs. 39.5 (25-50) mg/dl, P = 0.031. Multivariate logistic regression analyses identified 1-month HDL cholesterol >45 mg/dl as the only independent predictor of carotid stent patency at 1 year (P = 0.033, OR = 0.09, 95% CI 0.01-0.83). Postprocedural HDL cholesterol levels predict carotid stent patency at 1 year. With the possibility of elevation of HDL cholesterol by lifestyle changes and medication, this finding may have implications for the future management of patients undergoing CAS.
authors.affiliation: Department of Neurology, Academic Teaching Hospital Wagner-Jauregg, Linz, Austria. raffi.topakian@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Topakian
authors.forename: M
authors.initials: M
authors.lastname: Sonnberger
authors.forename: K
authors.initials: K
authors.lastname: Nussbaumer
authors.forename: H-P
authors.initials: HP
authors.lastname: Haring
authors.forename: J
authors.initials: J
authors.lastname: Trenkler
authors.forename: F T
authors.initials: FT
authors.lastname: Aichner
mesh_terms: D000368:Aged; D002339:Carotid Arteries; D016893:Carotid Stenosis / Q000628:therapy*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012008:Recurrence; D012307:Risk Factors; D015607:Stents; D020521:Stroke / Q000453:epidemiology; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D008076:Cholesterol, HDL