title: Chronic eosinophilic pneumonia in a 13-year-old child.
abstract: We report a case of a 13-year-old girl with an asymptomatic isoniazid-resistant tuberculosis contact. Six months after the contact had been made, chest radiography showed left upper lobe infiltrates without hilar lymphadenopathy, which led to the start of an antituberculous treatment. Tuberculin skin test remained negative and blood tests showed hypereosinophilia. One month after the onset of the treatment, she presented with asthenia, weight loss, and cough. She was admitted to our unit with a diagnosis of drug-resistant tuberculosis. Blood tests showed the persistence of hypereosinophilia. Chest radiograph and high-resolution lung computed tomography (CT) scan showed alveolar peripheral condensations on both upper lobes without significant hilar lymphadenopathy. Bronchoalveolar lavage (BAL) showed a normal total cell count with 44% of eosinophils. Microbiological analyses were all negative. Chronic eosinophilic pneumonia (CEP) was confirmed after the elimination of other different eosinophilic lung diseases. The patient was highly responsive to high doses of oral corticosteroids. Dyspnoea and cough disappeared within one week and chest CT scan showed regression of the lung infiltrates within one month. No relapse occurred during the following nine months.
authors.affiliation: Pediatric Pulmonary Department, AP-HP, Hopital Armand Trousseau, Université Pierre et Marie Curie-Paris 6, 28 avenue du Docteur Arnold Netter, Paris, 75012, France. nadia.nathan@trs.aphp.fr
authors.forename: Nadia
authors.initials: N
authors.lastname: Nathan
authors.forename: Nathalie
authors.initials: N
authors.lastname: Guillemot
authors.forename: Guillaume
authors.initials: G
authors.lastname: Aubertin
authors.forename: Sylvain
authors.initials: S
authors.lastname: Blanchon
authors.forename: Katarina
authors.initials: K
authors.lastname: Chadelat
authors.forename: Ralph
authors.initials: R
authors.lastname: Epaud
authors.forename: Annick
authors.initials: A
authors.lastname: Clément
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011657:Pulmonary Eosinophilia / Q000175:diagnosis*; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis