title: Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women.
abstract: BACKGROUND
  HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described.
  
  
  METHODS
  Multivariable linear regression analyzed the association between magnetic resonance imaging-measured regional adipose tissue and fasting lipids in 284 HIV-infected and 129 control women.
  
  
  RESULTS
  Among African Americans, HIV-infected women had higher triglyceride (116 vs. 83 mg/dL; P < 0.001), similar high-density lipoprotein (HDL; 52 vs. 50 mg/dL; P = 0.60), and lower low-density lipoprotein (LDL; 99 vs. 118 mg/dL; P = 0.008) levels than controls. Among whites, HIV-infected women had higher triglyceride (141 vs. 78 mg/dL; P < 0.001), lower HDL (46 vs. 57 mg/dL; P < 0.001), and slightly lower LDL (100 vs. 107 mg/dL; P = 0.059) levels than controls. After adjustment for demographic and lifestyle factors, the highest tertile of visceral adipose tissue (VAT) was associated with higher triglyceride (+85%, 95% confidence interval [CI]: 55 to 121) and lower HDL (-9%, 95% CI: -18 to 0) levels in HIV-infected women; the highest tertile of leg subcutaneous adipose tissue (SAT) was associated with lower triglyceride levels in HIV-infected women (-28%, 95% CI: -41 to -11) and controls (-39%, 95% CI: -5 to -18). After further adjustment for adipose tissue, HIV infection remained associated with higher triglyceride (+40%, 95% CI: 21 to 63) and lower LDL (-17%, 95% CI: -26 to -8) levels, whereas HIV infection remained associated with lower HDL levels (-21%, 95% CI: -29 to -12) in whites but not in African Americans (+8%, 95% CI: -2 to 19).
  
  
  CONCLUSIONS
  HIV-infected white women are more likely to have proatherogenic lipid profiles than HIV-infected African American women. Less leg SAT and more VAT are important factors associated with adverse lipid levels. HIV-infected women may be at particular risk for dyslipidemia because of the risk for HIV-associated lipoatrophy.
authors.affiliation: Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Currier
authors.forename: Rebecca
authors.initials: R
authors.lastname: Scherzer
authors.forename: Peter
authors.initials: P
authors.lastname: Bacchetti
authors.forename: Steven
authors.initials: S
authors.lastname: Heymsfield
authors.forename: Daniel
authors.initials: D
authors.lastname: Lee
authors.forename: Stephen
authors.initials: S
authors.lastname: Sidney
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Tien
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D015999:Multivariate Analysis; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D014280:Triglycerides