T-cell receptor bias and immunity.
Despite the potentially vast T-cell repertoire, biased alphabeta T-cell receptor (TCR) usage has emerged as a common theme in immunity. Examples of TCR bias are observed in classical polymorphic major histocompatibility complex (MHC)-restricted immune responses as well as in T-cell responses to non-classical, monomorphic Ag-presenting molecules, such as CD1d. Recent data have implicated the structural landscape of these antigen-presenting molecules as one of the drivers of TCR bias. Here we review recent advances in the field, focussing on structural data pertaining to biased TCR usage, and discuss the implications for T-cell repertoire selection, MHC restriction and therapeutic development.
Gras
Stephanie
S
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.
Kjer-Nielsen
Lars
L
Burrows
Scott R
SR
McCluskey
James
J
Rossjohn
Jamie
J
D000818:Animals; D017951:Antigen Presentation; D015551:Autoimmunity; D020031:Epstein-Barr Virus Infections / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D006649:Histocompatibility Antigens / Q000737:chemistry; D006801:Humans; D007251:Influenza, Human / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry*
D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell