Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes.
We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin's lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin's lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.
Ryazantseva
N V
NV
Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk.
Novitskii
V V
VV
Litvinova
L S
LS
Tkachenko
S B
SB
Kolobovnikova
Yu V
YV
Zhukova
O B
OB
Grigor'eva
E S
ES
Suvorova
E V
EV
Knutareva
E N
EN
Radzivil
T T
TT
Chasovskikh
N Yu
NY
D000293:Adolescent; D000328:Adult; D017209:Apoptosis / Q000187:drug effects*; D016022:Case-Control Studies; D002478:Cells, Cultured; D019742:Chemokines, CC / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D004802:Eosinophilia / Q000097:blood; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D015848:Interleukin-5 / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000378:metabolism / Q000494:pharmacology*
D019742:Chemokines, CC; D007377:Interleukin-3; D015848:Interleukin-5; D011994:Recombinant Proteins