title: Sequence of electrical activation, atrial remodelling and atrial fibrillation in patients with nodal re-entrant tachycardia.
abstract: OBJECTIVE
  The objective of the study was to verify, if the particular sequence of electrical atrioventricular activation during tachycardia is associated with the development of atrial remodelling and predisposition to atrial fibrillation (AF) in patients with nodal reentry tachycardia (AVNRT).
  
  
  RESULTS
  We assessed 117 consecutive patients with AVNRT identified during electrophysiological study. Two groups were identified: the AF group, n = 21 (17.9%, median age 46.0, 15 women), with clinically documented AF, and the control group, n = 96, without AF (median age 48.5, 69 women). Tachycardia cycle length (VV), anterograde AV, retrograde VA activation intervals and indexes (AV/VV, VA/VV) during AVNRT, atrial refractory period (AERP), intraatrial (IntraCT) and interatrial conduction time (InterCT) of the sinus beat and premature stimuli were analysed. The longer retrograde and shorter anterograde activation was found in AF patients with typical AVNRT, the opposite relations showed the subjects with atypical tachycardia. Intra and InterCT of sinus beat, and of paced extrastimuli were longer, AERP was borderline shorter in the AF-group than in the controls. The longest conduction times and shortest AERP were seen in the patients with VA/VV within 20-40% of the tachycardia cycle, this group comprised 71% of all AF-patients (P< 0.001).VA was predictive for AF in typical (OR/unit 1.04) and atypical AVNRT (OR/unit 0.93, P< 0.05).
  
  
  CONCLUSIONS
  The particular sequence of electrical atrioventricular activation, seen in some patients during AVNRT, is associated with disturbances of atrial conduction, refractoriness and predisposes to atrial fibrillation.
authors.affiliation: First Department of Cardiology, Silesian Medical School, Silesian Center for Heart Diseases, Zabrze, Poland. elfizab@poczta.onet.pl
authors.forename: Radosław
authors.initials: R
authors.lastname: Lenarczyk
authors.forename: Oskar
authors.initials: O
authors.lastname: Kowalski
authors.forename: Patrycja
authors.initials: P
authors.lastname: Pruszkowska-Skrzep
authors.forename: Jacek
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Teresa
authors.initials: T
authors.lastname: Zielińska
authors.forename: Witold
authors.initials: W
authors.lastname: Streb
authors.forename: Joanna
authors.initials: J
authors.lastname: Stabryła-Deska
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Kalarus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology*; D016275:Atrial Function / Q000502:physiology*; D002648:Child; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000209:etiology / Q000503:physiopathology*