title: A novel HLA-B*57 (B*5714) allele in a healthy male Caucasian individual.
abstract: A novel human leucocyte antigen (HLA)-B57 (HLA-B*5714) allele has been identified in a male Caucasian individual from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*570101 allele except for two point mutations in exon 3 at codon 138 (ACG-->ACC) with no amino acid change [persisting threonine (T)] and at codon 171 (TAC-->CAC), resulting in an amino acid change from tyrosine (Y) to histidine (H).
authors.affiliation: Interbranch HLA-Laboratory, Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle, Germany. buero.ghatt@medizin.uni-halle.de
authors.forename: W W
authors.initials: WW
authors.lastname: Altermann
authors.forename: V
authors.initials: V
authors.lastname: Grondkowski
authors.forename: S
authors.initials: S
authors.lastname: Reichert
authors.forename: B
authors.initials: B
authors.lastname: Seliger
authors.forename: G
authors.initials: G
authors.lastname: Schlaf
mesh_terms: D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D017386:Sequence Homology, Amino Acid; D009626:Terminology as Topic; D044465:White People / Q000235:genetics
chemical_list: D015235:HLA-B Antigens; C103707:HLA-B57 antigen; D004247:DNA