title: Regional differences in the risk of triple class failure in European patients starting combination antiretroviral therapy after 1 January 1999.
abstract: Regional differences across Europe in triple class failure (TCF; the failure of each of the three separate main classes of antiretrovirals (ARVs) with a viral load >1000 HIV-1 RNA copies/mL for >4 months) have not been described. A total of 1956 patients started combination ARV therapy after 1 January 1999, of whom 123 patients developed TCF [6.3%; incidence 16.7 per 1000 person-years of follow-up; 95% confidence interval (CI) 13.7-19.6]. After adjustment, patients from Eastern Europe had a significantly increased incidence of TCF compared with patients from Southern Europe/Argentina (3.05; 95% CI 1.36-6.82; P=0.0067) while patients taking either a boosted protease inhibitor regimen (0.33; 95% CI 0.15-0.74; P=0.0072) or a nonnucleotide reverse transcriptase inhibitor (NNRTI)-based regimen (0.59; 95% CI 0.37-0.94; P=0.026) had a reduced incidence of TCF.
authors.affiliation: Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK. a.mocroft@pcps.ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Mocroft
authors.forename: A
authors.initials: A
authors.lastname: Horban
authors.forename: B
authors.initials: B
authors.lastname: Clotet
authors.forename: A
authors.initials: A
authors.lastname: d'Arminio Monforte
authors.forename: J R
authors.initials: JR
authors.lastname: Bogner
authors.forename: P
authors.initials: P
authors.lastname: Aldins
authors.forename: T
authors.initials: T
authors.lastname: Staub
authors.forename: F
authors.initials: F
authors.lastname: Antunes
authors.forename: C
authors.initials: C
authors.lastname: Katlama
authors.forename: J D
authors.initials: JD
authors.lastname: Lundgren
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005060:Europe / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D012306:Risk; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents