Skin deep: enhanced sleep depth by cutaneous temperature manipulation.
With ageing, an increasingly disturbed sleep is reported as a significant complaint affecting the health and well-being of many people. The available treatments for sleep disturbance have their limitations, so we have adopted a different approach to the improvement of sleep. Since in animal and human studies skin warming has been found to increase neuronal activity in brain areas that are critically involved in sleep regulation, we investigated whether subtle skin temperature manipulations could improve human sleep. By employing a thermosuit to control skin temperature during nocturnal sleep, we demonstrate that induction of a mere 0.4 degrees C increase in skin temperature, whilst not altering core temperature, suppresses nocturnal wakefulness (P<0.001) and shifts sleep to deeper stages (P<0.001) in young and, especially, in elderly healthy and insomniac participants. Elderly subjects showed such a pronounced sensitivity, that the induced 0.4 degrees C increase in skin temperature was sufficient to almost double the proportion of nocturnal slow wave sleep and to decrease the probability of early morning awakening from 0.58 to 0.04. Therefore, skin warming strongly improved the two most typical age-related sleep problems; a decreased slow wave sleep and an increased risk of early morning awakening. EEG frequency spectra showed enhancement of low-frequency cortical oscillations. The results indicate that subtle feedback control of in-bed temperature through very mild manipulations could have strong clinical relevance in the management of disturbed sleep especially in the elderly, who have an attenuated behavioural response to suboptimal environmental temperature, which may hamper them from taking appropriate action to optimize their bed temperature.
Raymann
Roy J E M
RJ
Department of Sleep & Cognition, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. raymann@nin.knaw.nl
Swaab
Dick F
DF
Van Someren
Eus J W
EJ
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology / Q000523:psychology; D001833:Body Temperature Regulation / Q000502:physiology*; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006361:Heating; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D012881:Skin Temperature / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology / Q000628:therapy*; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology