title: Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60-kDa heat shock protein is associated with decreased spontaneous fertility rate in ectopic pregnant women treated by salpingectomy.
abstract: OBJECTIVE
  This prospective study was aimed to evaluate whether non-invasive clinical and serologic parameters of tubal disease are predictive for subsequent spontaneous conception and pregnancy outcome after first episode of ectopic pregnancy (EP).
  
  
  METHODS
  Overall, 144 women aged <35 years were enrolled. Outcome of subsequent spontaneous conception was analyzed after 3 years and compared with clinical parameters and antibody responses to Chlamydia trachomatis and epitopes of the 60-kDa chlamydial heat shock protein (CHSP-60).
  
  
  RESULTS
  Antibody response to a conserved epitope of CHSP-60 (amino acids, aa 260-277) was independently correlated with both decreased spontaneous conception and term delivery rates (adjusted odds ratios, OR: 3.6 and 5.4, respectively).
  
  
  CONCLUSIONS
  Presence of circulating antibodies to a conserved epitope of the CHSP-60 is associated with a lower spontaneous conception rate, and increased likelihood of adverse pregnancy outcome in women treated by salpingectomy for first episode of EP.
authors.affiliation: First Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. sziller@noi1.sote.hu
authors.forename: István
authors.initials: I
authors.lastname: Sziller
authors.forename: Peter
authors.initials: P
authors.lastname: Fedorcsák
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Csapó
authors.forename: Katalin
authors.initials: K
authors.lastname: Szirmai
authors.forename: Iara M
authors.initials: IM
authors.lastname: Linhares
authors.forename: Zoltàn
authors.initials: Z
authors.lastname: Papp
authors.forename: Steven S
authors.initials: SS
authors.lastname: Witkin
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007246:Infertility / Q000276:immunology* / Q000382:microbiology; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000276:immunology* / Q000382:microbiology / Q000601:surgery; D011446:Prospective Studies
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D000939:Epitopes; C067562:protein 60K, Chlamydia trachomatis