title: Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: a facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy.
abstract: Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO2(Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spin-orbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan 106, ROC.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Lai
authors.forename: Yu-Hsiu
authors.initials: YH
authors.lastname: Wang
authors.forename: Cheng-Hsuan
authors.initials: CH
authors.lastname: Lai
authors.forename: Meng-Ju
authors.initials: MJ
authors.lastname: Yang
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Chen
authors.forename: Pi-Tai
authors.initials: PT
authors.lastname: Chou
authors.forename: Chi-Shun
authors.initials: CS
authors.lastname: Chan
authors.forename: Yun
authors.initials: Y
authors.lastname: Chi
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Jong-Kai
authors.initials: JK
authors.lastname: Hsiao
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media; D052203:Ferrosoferric Oxide; D006367:HeLa Cells; D006801:Humans; D007495:Iridium; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D012822:Silicon Dioxide; D026082:Singlet Oxygen; D013053:Spectrophotometry
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D007495:Iridium; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide