title: Evolution of complexity in miRNA-mediated gene regulation systems.
abstract: Using Arabidopsis microRNA (miRNA)-mediated gene regulation system as a model, we investigated how complex systems evolve with special attention to selection to maintain the systems. We found that the copy number of miRNA genes within each system is a key factor to determine the complexity of the system, indicating a crucial role of gene duplication to increase the complexity. Furthermore, we show that the mode of selection to maintain the systems depend on their complexity levels.
authors.affiliation: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Shohei
authors.initials: S
authors.lastname: Takuno
authors.forename: Hideki
authors.initials: H
authors.lastname: Innan
mesh_terms: D017360:Arabidopsis / Q000235:genetics; D001483:Base Sequence; D019143:Evolution, Molecular; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D005810:Multigene Family; D018749:RNA, Plant / Q000235:genetics; D012641:Selection, Genetic
chemical_list: D035683:MicroRNAs; D018749:RNA, Plant