title: Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.
abstract: It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.
authors.affiliation: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Need
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Attix
authors.forename: Jill M
authors.initials: JM
authors.lastname: McEvoy
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Cirulli
authors.forename: Kristen N
authors.initials: KN
authors.lastname: Linney
authors.forename: Ana Patricia
authors.initials: AP
authors.lastname: Wagoner
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Gumbs
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Clyde
authors.initials: C
authors.lastname: Francks
authors.forename: Pierandrea
authors.initials: P
authors.lastname: Muglia
authors.forename: Allen
authors.initials: A
authors.lastname: Roses
authors.forename: Greg
authors.initials: G
authors.lastname: Gibson
authors.forename: Mike E
authors.initials: ME
authors.lastname: Weale
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: David B
authors.initials: DB
authors.lastname: Goldstein
mesh_terms: D015331:Cohort Studies; D005060:Europe; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008568:Memory / Q000502:physiology*; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D015203:Reproducibility of Results; D044465:White People
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human