Antigenotoxic effect of apigenin against anti-cancerous drugs.
Mitomycin C and cyclophosphamide are well known anti-tumor drugs. Their genotoxic effects are well established in various test systems. The genotoxic effects in non-tumor cell are of special significance due to the possibility that they may induce secondary tumors in cancer patients. Apigenin is a well known anti-oxidant and possess number of properties that are beneficial in some way to humans. With this view, the present study deals with the effect of apigenin against the genotoxic doses of mitomycin C and cyclophosphamide using chromosomal aberrations, sister chromatid exchanges and cell cycle kinetics as a parameters. The treatment of apigenin results in a significant, dose dependent decrease in the genotoxic damage, induced by mitomycin C and cyclophosphamide. It is concluded that the apigenin is potent in reducing the genotoxic damage, induced by anti-cancerous drugs, thereby reducing the chances of developing secondary tumors during the therapy.
Siddique
Yasir Hasan
YH
Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202002, India. yasir_hasansiddique@rediffmail.com
Beg
Tanveer
T
Afzal
Mohammad
M
D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors / Q000633:toxicity; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D018906:Antineoplastic Agents, Alkylating / Q000037:antagonists & inhibitors / Q000633:toxicity; D047310:Apigenin / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000633:toxicity; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D016685:Mitomycin / Q000037:antagonists & inhibitors / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D009153:Mutagens; D016685:Mitomycin; D047310:Apigenin; D003520:Cyclophosphamide