The association between polypronucleate zygote formation with certain motion characteristics of sperm and IVF outcome.
OBJECTIVE
To determine the efficiency of sperm motion characteristics as predictors for normal (2PN) and polypronulceate (PPN) zygotes in IVF.


METHODS
A retrospective cohort analysis for a total of 230 couples undergoing IVF treatment in a single infertility center.


RESULTS
Subsequent to semen analysis and hemizona assay, unexpected fertilization failure would appear to have occurred only extremely rarely (1/236, 0.4%). The rate of PPN, however, did arise and appeared to be related to certain sperm motion characteristics, such as lateral head displacement and concentration of progressive motile sperm. Interestingly, the patients featuring a high PPN rate (>20%) was associated with a greater pregnancy rate than those featuring a low PPN rate (<20%).


CONCLUSIONS
The sperm motion characteristics examined herein could be utilized to predict the rate of PPN in IVF. In order to enhance the rate of 2PN and maintain the relative high rate of clinical pregnancy, an efficient method needs further investigation and development.
Lee
Tsung-Hsien
TH
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liu
Chung-Hsien
CH
Huang
Chun-Chia
CC
Chen
Hsui-Hui
HH
Chen
Shee-Uan
SU
Lee
Maw-Sheng
MS
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013084:Sperm-Ovum Interactions; D015053:Zygote / Q000166:cytology* / Q000378:metabolism