title: Predicting cancer on excision of atypical ductal hyperplasia.
abstract: BACKGROUND
  There are no specific histopathologic factors that allow identification of patients with atypical ductal hyperplasia (ADH) who will have cancer on final excision.
  
  
  METHODS
  This was a retrospective study of all patients who had ADH on biopsy followed by excision from 1999 to 2006.
  
  
  RESULTS
  Fifty-one patients were found to have ADH on core biopsy. Eight (15.7%) patients had invasive carcinoma on surgical excision, 9 (17.5%) had ductal carcinoma-in-situ (DCIS), 21 (41.5%) had ADH, 4 (8%) patients had atypical lobular hyperplasia, and 9 (17.5%) had benign tumors. The grade of atypia on the core biopsy was mild in 13 (25%) patients, moderate in 22 (43%), and marked in 16 (32%). On multivariate analysis of histopathologic factors, the grade of atypia was the only significant variable that predicted a diagnosis of cancer on final surgical excision (P = .001).
  
  
  CONCLUSIONS
  The grade of atypia correlated with the presence of cancer on surgical excision.
authors.affiliation: Department of Surgery, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Doren
authors.forename: Melissa
authors.initials: M
authors.lastname: Hulvat
authors.forename: Jonathan
authors.initials: J
authors.lastname: Norton
authors.forename: Prabha
authors.initials: P
authors.lastname: Rajan
authors.forename: Sharfi
authors.initials: S
authors.lastname: Sarker
authors.forename: Gerard
authors.initials: G
authors.lastname: Aranha
authors.forename: Katharine
authors.initials: K
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies