Attenuation of diastolic heart failure and life-threatening ventricular tachyarrhythmia after peripheral blood stem cell transplantation combined with cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis.
A patient had multiple myeloma and associated cardiac amyloidosis, which caused diastolic dysfunction and recurrent ventricular fibrillation. After implantation of a cardioverter-defibrillator (ICD), the patient underwent autologous peripheral blood stem cell transplantation (PBSCT). The life-threatening arrhythmias, such as ventricular fibrillation, disappeared, and diastolic dysfunction assessed by quantitative gated single photon emission computed tomography and Doppler echocardiography improved 7 months later. This may be the first report to document improvement of both a lethal rhythm disorder and diastolic dysfunction by PBSCT following ICD implantation in a case of cardiac amyloidosis associated with multiple myeloma.
Yaoita
Hiroyuki
H
First Department ofInternal Medicine, Fukushima Medical University, Hikarigaoka 1,Fukushima 960-1295, Japan.
Iwai-Takano
Masumi
M
Ogawa
Kazuei
K
Suzuki
Hitoshi
H
Akutsu
Kazuko
K
Noji
Hideyoshi
H
Kamiyama
Yoshiyuki
Y
Kimura
Satoshi
S
Ohtake
Hideki
H
Ishibashi
Toshiyuki
T
Maruyama
Yukio
Y
D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D017147:Defibrillators, Implantable; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011859:Radiography; D013610:Tachycardia / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D013997:Time Factors; D014182:Transplantation, Autologous; D014463:Ultrasonography