title: Association of non-specific inflammatory activation with early mortality in patients with ST-elevation acute coronary syndrome treated with primary angioplasty.
abstract: BACKGROUND
  The association of inflammatory markers with mortality in ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) remains controversial, so in the present study the relationships of high-sensitivity C-reactive protein (hs-CRP), total white blood cell (WBC) count, neutrophil (N) and lymphocyte (L) counts and the N/L ratio with occurrence of in-hospital mortality were assessed in patients with STEMI treated with primary PCI.
  
  
  RESULTS
  Inflammatory parameters were assessed on admission in 1,078 consecutive, unselected patients with STEMI admitted for primary PCI. In-hospital death occurred in 6.3% of the patients. Of the inflammatory parameters, only hs-CRP (p<0.001), and the WBC (p=0.004) and N (p=0.020) counts were predictors of death in the univariate analyses. After adjustment for other baseline clinical variables both hs-CRP and WBC count retained their independent association with mortality when analyzed both in 2 separate and in 1 multivariable models.
  
  
  CONCLUSIONS
  Both hs-CRP and the WBC count may independently of each other predict early outcomes in STEMI patients treated with primary PCI, which suggests different pathological significance of these 2 non-specific inflammatory markers in STEMI.
authors.affiliation: Cathetherization Laboratory and Coronary Disease Unit, National Institute of Cardiology, Warsaw, Poland. mkruk@ikard.pl
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kruk
authors.forename: Jakub
authors.initials: J
authors.lastname: Przyłuski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Kalińczuk
authors.forename: Jerzy
authors.initials: J
authors.lastname: Pregowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Deptuch
authors.forename: Jacek
authors.initials: J
authors.lastname: Kadziela
authors.forename: Paweł
authors.initials: P
authors.lastname: Bekta
authors.forename: Maciej
authors.initials: M
authors.lastname: Karcz
authors.forename: Marcin
authors.initials: M
authors.lastname: Demkow
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Chmielak
authors.forename: Adam
authors.initials: A
authors.lastname: Witkowski
authors.forename: Witold
authors.initials: W
authors.lastname: Ruzyłło
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications / Q000401:mortality* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality* / Q000628:therapy; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein