Male reproductive proteins and reproductive outcomes.
Male reproductive proteins (MRPs), associated with sperm and semen, are the moieties responsible for carrying male genes into the next generation. Evolutionary biologists have focused on their capacity to control conception. Immunologists have shown that MRPs cause female genital tract inflammation as preparatory for embryo implantation and placentation. These observations argue that MRPs are critically important to reproductive success. Yet the impact of male reproductive proteins on obstetrical outcomes in women is largely unstudied. Epidemiologic and clinical observations suggest that shorter-duration exposure to MRPs prior to conception may elevate the risk for preeclampsia. A limited literature has also linked sexual behavior to bacterial vaginosis and preterm birth. We offer a clinical opinion that MRPs may have broad implications for successful reproduction, potentially involved in the composition of vaginal microflora, risks of preterm birth and preeclampsia, and success of assisted reproduction.
Ness
Roberta B
RB
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA. repro@edc.pitt.edu
Grainger
David A
DA
D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood; D008297:Male; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D047928:Premature Birth / Q000503:physiopathology*; D012098:Reproduction; D012307:Risk Factors; D012661:Semen / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*; D048069:Tumor Necrosis Factors / Q000097:blood
D007378:Interleukins; D048069:Tumor Necrosis Factors; D016173:Macrophage Colony-Stimulating Factor