title: Soluble fragment of HER2/neu receptor in the serum of patients with breast cancer with different levels of this protein expression in the tumor.
abstract: Serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein (2+/3+ according to immunohistochemical analysis) was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands. The level of HER2/neu in the serum decreased after removal of the primary tumor in the majority of patients.
authors.affiliation: N. N. Blokhin National Oncological Research Center, Russian Academy of Medical Sciences, Moscow.
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
authors.forename: V P
authors.initials: VP
authors.lastname: Shirokii
authors.forename: E S
authors.initials: ES
authors.lastname: Gershtein
authors.forename: V D
authors.initials: VD
authors.lastname: Yermilova
authors.forename: G Yu
authors.initials: GY
authors.lastname: Chemeris
authors.forename: V P
authors.initials: VP
authors.lastname: Letyagin
mesh_terms: D001940:Breast / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D001941:Breast Diseases / Q000097:blood / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000097:blood*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases