title: Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles.
abstract: Most pharmaceutical compounds can benefit from being produced with a small particle size to enhance processing or therapeutic performance. Confined liquid impinging jets (CLIJ) were employed in this study to evaluate the feasibility and limitations in the production of nanodrugs (i.e., particle size in the nanorange). Four drugs from different pharmaceutical classes and water solubilities - salbutamol sulfate, mannitol, ibuprofen, and cyclosporine - were examined. Particles of salbutamol sulfate and cyclosporine with diameters of approximately 300 nm were successfully achieved. The use of CLIJ thus shows potential in the production of nanopharmaceuticals for certain compounds.
authors.affiliation: Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, New South Wales, Australia.
authors.forename: Herbert
authors.initials: H
authors.lastname: Chiou
authors.forename: Hak-Kim
authors.initials: HK
authors.lastname: Chan
authors.forename: Robert K
authors.initials: RK
authors.lastname: Prud'homme
authors.forename: Judy A
authors.initials: JA
authors.lastname: Raper
mesh_terms: D011232:Chemical Precipitation; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations