ATP-dependent chromatosome remodeling.
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime. One important principle that endows chromatin with flexibility involves ATP-dependent 'remodeling' factors, which alter DNA-histone interactions to form, disrupt or move nucleosomes. Remodeling is well documented at the nucleosomal level, but little is known about the action of remodeling factors in a more physiological chromatin environment. Recent findings suggest that some remodeling machines can reorganize even folded chromatin fibers containing the linker histone H1, extending the potential scope of remodeling reactions to the bulk of euchromatin.
Maier
Verena K
VK
Adolf-Butenandt Institut, Abt. Molekularbiologie, and Münchner Zentrum für Integrierte Proteinforschung, Ludwig-Maximilian-Universität München, Schillerstrasse 44, D-80336 München, Germany.
Chioda
Mariacristina
M
Becker
Peter B
PB
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism*
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases