title: Pulmonary and systemic toxicity of bleomycin on severe combined immune deficiency mice.
abstract: Severe combined immune deficiency (SCID) mice were more sensitive to systemic delivery of bleomycin (BLM) than the wild-type strain, and died from esophagitis. Lung injury in the SCID mice by its intratracheal injection, however, was of comparable degree but with less lymphocyte infiltration than that in the wild-type mice. Macrophages and lymphocytes increased transiently in bronchoalveolar lavage fluid of SCID mice, whereas their increase in wild-type was continuous. Unsustainable inflammation in the lung might reduce BLM-induced lung injury in BLM-sensitive SCID mice.
authors.affiliation: Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Katsushi
authors.initials: K
authors.lastname: Kurosu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Sakao
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanabe
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002465:Cell Movement; D004941:Esophagitis / Q000139:chemically induced*; D008171:Lung Diseases / Q000139:chemically induced*; D008214:Lymphocytes; D008264:Macrophages; D051379:Mice; D016513:Mice, SCID
chemical_list: D001761:Bleomycin