Antitumor efficacy of autovaccines prepared from chemoresistant tumor cells with the use of lectin OF B. subtilis B-7025.
OBJECTIVE
To study whether immunogenecity of tumor cells may be altered upon the development of cytostatic drug resistance and what is the efficacy of vaccines prepared from such tumor cells.


METHODS
Using immunological methods, the influence of vaccines prepared from Lewis lung carcinoma (LLC) cells, sensitive or resistant to cisplatin, with the use of cytotoxic lectins of B. subtilis B-7025 on the course of tumor development and the main effector reactions of antitumor resistance has been studied.


RESULTS
The vaccine prepared from the cells of chemoresistant LLC and lectines of B. subtilis B-7025 possesses antitumor activity, what is evidenced by the indexes of tumor growth inhibition and increased activity of effector cells of antitumor immunity.


CONCLUSIONS
The antitumor action of vaccines prepared with the use of chemoresistant tumor cells is differing is more pronounced, than in the case of chemosensitive variant.
Potebnya
G
G
RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kiev, Ukraine. iris@onconet.kiev.ua
Cheremshenko
N
N
Lisovenko
G
G
Voyekova
I
I
Bazas'
V
V
Todor
I
I
Chekhun
V
V
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000737:chemistry; D019496:Cancer Vaccines / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000628:therapy*; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D037102:Lectins / Q000627:therapeutic use*; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D037102:Lectins; D002945:Cisplatin