Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore.
T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation.
Sundrud
Mark S
MS
Department of Pathology, Harvard Medical School, and Immune Disease Institute, Boston, MA 02115, USA.
Rao
Anjana
A
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology / Q000378:metabolism
D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone