title: Scanning probe recognition microscopy investigation of tissue scaffold properties.
abstract: Scanning probe recognition microscopy is a new scanning probe microscopy technique which enables selective scanning along individual nanofibers within a tissue scaffold. Statistically significant data for multiple properties can be collected by repetitively fine-scanning an identical region of interest. The results of a scanning probe recognition microscopy investigation of the surface roughness and elasticity of a series of tissue scaffolds are presented. Deconvolution and statistical methods were developed and used for data accuracy along curved nanofiber surfaces. Nanofiber features were also independently analyzed using transmission electron microscopy, with results that supported the scanning probe recognition microscopy-based analysis.
authors.affiliation: Electronic and Biological Nanostructures Laboratory, College of Engineering, Michigan State University, East Lansing, MI, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fan
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Ayres
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Baczewski
authors.forename: Lalita
authors.initials: L
authors.lastname: Udpa
authors.forename: Shiva
authors.initials: S
authors.lastname: Kumar
mesh_terms: D004548:Elasticity; D005109:Extracellular Matrix / Q000737:chemistry*; D006244:Hardness; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008422:Materials Testing / Q000379:methods*; D020527:Microscopy, Scanning Probe / Q000379:methods*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D037742:Nanotubes, Carbon