Unexpected recovery of ovarian function many years after bone marrow transplantation.
Premature ovarian failure as a consequence of childhood cancer treatment is considered permanent when present long after the initial insult. We report spontaneous recovery of ovarian function occurring 8 years after bone marrow transplantation in a girl with history of leukemia and growth hormone deficiency. Clinical management challenges are discussed.
Rahhal
Samar N
SN
Section of Pediatric Endocrinology/Diabetology, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana, USA.
Eugster
Erica A
EA
D001827:Body Height; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D010050:Ovarian Function Tests; D010053:Ovary / Q000473:pathology* / Q000502:physiology*; D016649:Primary Ovarian Insufficiency; D011627:Puberty; D014916:Whole-Body Irradiation
D013006:Growth Hormone