[Neoadjuvant chemotherapy for gastric cancer with peritoneal dissemination].
An early detection and treatment of gastric cancer with peritoneal dissemination are rather difficult so that a clinical trial has been neglected. Therefore, we introduced a pre-operative peritoneal lavage diagnosis for gastric cancer patients with serosa-invaded tumors. Neoadjuvant chemotherapy was introduced to patients with positive cytology and with no non-curative factors except peritoneum. The neoadjuvant chemotherapy followed by surgery was done safely. The patients with the disappearance of CY and P factors due to neoadjuvant chemotherapy had a better prognosis than those with positive results of CY or R However, many of the patients with negative results from peritoneum eventually suffered a peritoneal recurrence. We started another protocol study with S-1 and an intra-peritoneal chemotherapy using docetaxel. The efficacy in the protocol result will be expected.
Fujiwara
Yoshiyuki
Y
Dept. of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.
Doki
Yuichiro
Y
Takiguchi
Shuji
S
Miyata
Hiroshi
H
Yamazaki
Makoto
M
Nishida
Toshiro
T
Monden
Morito
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D000077143:Docetaxel; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects; D010094:Oxonic Acid / Q000627:therapeutic use; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D043823:Taxoids / Q000627:therapeutic use; D005641:Tegafur / Q000627:therapeutic use
D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D005472:Fluorouracil