title: Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate.
abstract: The pyran-containing fragments 1 and 2 of AM3 have been synthesized from the common pyran intermediate 3. Careful orchestration of the alcohol protecting groups was necessary to facilitate deprotection of alcohol functionality in the presence of the chemically sensitive polyene chain.
authors.affiliation: Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
authors.forename: Jacqueline D
authors.initials: JD
authors.lastname: Hicks
authors.forename: William R
authors.initials: WR
authors.lastname: Roush
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D000095722:Amphidinols
chemical_list: D000438:Alcohols; D000475:Alkenes; D011090:Polyenes; D011714:Pyrans; C438973:amphidinol 3; D000095722:Amphidinols