Primary thyroid-like papillary adenocarcinoma of the nasopharynx.
Thyroid-like papillary adenocarcinoma is an extremely rare neoplasm in the nasopharynx. We present a case with a pedunculated tumor in the nasopharyngeal vault and the preoperative biopsy revealed a thyroid-like papillary adenocarcinoma. Complete tumor resection via modified facial translocation was undergone subsequently. Postoperative histopathological examinations and immunohistochemical studies confirmed the diagnosis. Regarding the association with Epstein-Barr virus (EBV), the tumor was negative for both small EBV-encoded RNA (EBER) and EBV latent membrane protein-1 (LMP-1) oncogene. This rare neoplasm demonstrated a distinct etiology and nature from typical nasopharyngeal carcinomas and should be managed mainly by surgical resection.
Fu
Chia-Hsiang
CH
Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.
Chang
Kai-Ping
KP
Ueng
Shir-Hwa
SH
Wu
Chia-Chen
CC
Hao
Sheng-Po
SP
D000231:Adenocarcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004724:Endoscopy; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009305:Nasopharynx / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis; D014057:Tomography, X-Ray Computed