Evaluation of a disposable device for the measurement of haemoglobin A1c in dogs.
A disposable device designed for measuring glycated haemoglobin (hba1c) in human blood was evaluated for use in dogs. edta blood samples were collected from 50 normoglycaemic dogs, 10 dogs suffering from anaemia and 112 diabetic dogs. hba1c was measured in all the dogs except for five of the diabetic animals, in which the concentrations were above the range of the device, that is, more than 13 per cent, and two of the anaemic dogs, in which they were below its limit of detection, that is less than 3 per cent. The diabetic dogs had higher hba1c values (range 4.9 to >13 per cent, median 9.3 per cent) than the normoglycaemic dogs (range 3.7 to 5.6 per cent, median 4.7 per cent). In the anaemic dogs the values were significantly lower (range <3.0 per cent to 5.2 per cent, median 3.5 per cent) than in the normoglycaemic dogs. There was a good correlation (R(2)=0.48) between the measurements obtained with the device and the measurements obtained with a system already validated for use in dogs.
Catchpole
B
B
Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA.
Mountford
S
S
Barabas
S
S
Scaramuzzi
R J
RJ
D000740:Anemia / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D006442:Glycated Hemoglobin / Q000032:analysis*; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods / Q000592:standards / Q000662:veterinary*; D019095:Point-of-Care Systems; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D006442:Glycated Hemoglobin