title: 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence.
abstract: We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3-24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported.
authors.affiliation: Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
authors.forename: L K
authors.initials: LK
authors.lastname: Carr
authors.forename: D
authors.initials: D
authors.lastname: Steele
authors.forename: S
authors.initials: S
authors.lastname: Steele
authors.forename: D
authors.initials: D
authors.lastname: Wagner
authors.forename: R
authors.initials: R
authors.lastname: Pruchnic
authors.forename: R
authors.initials: R
authors.lastname: Jankowski
authors.forename: J
authors.initials: J
authors.lastname: Erickson
authors.forename: J
authors.initials: J
authors.lastname: Huard
authors.forename: M B
authors.initials: MB
authors.lastname: Chancellor
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D032446:Myoblasts / Q000637:transplantation*; D010865:Pilot Projects; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D014550:Urinary Incontinence, Stress / Q000628:therapy*