[Study on rules of TCM syndrome in patients with dyslipidemia and its objectization].
OBJECTIVE
To explore the rules of TCM syndrome in patients with dyslipidemia and its relation with C-reactive protein (CRP), homocysteine (Hcy), carotid ultrasonic picture, blood lipids and blood viscosity.


METHODS
From 152 recruited patients symptoms and physical signs (including figures of tongue and pulse) were selected and analyzed in grading and quantifying by factor analysis. At the same time, blood lipids, CRP, Hcy, carotid ultrasonic picture and blood viscosity were detected to conduct a canonical correlation analysis for exploring the relationship between different TCM syndromes and their corresponding physical and/or chemical indexes.


RESULTS
Five types of TCM syndrome obtained by factor analysis were syndrome of Shen-yin deficiency (I), Pi-qi deficiency (II), turbid-phlegm impediment (III), blood stasis (IV), and phlegm-blood block (V). By canonical correlation analysis, they were characterized with: Type I, high levels of CRP and blood viscosity; Type II, high level of very low-density lipoprotein cholesterol (VLDL-C); Type III, high level of total cholesterol (TC) and low level of high-density lipoprotein cholesterol (HDL-C); and Type V, high level of Hcy.


CONCLUSIONS
The five syndrome types frequently found in patients with dyslipidemia are syndrome of Shen-yin deficiency, Pi-qi deficiency, turbid-phlegm impediment, blood stasis, and phlegm-blood block. Different syndrome has its own correlation with some corresponding physical and/or chemical laboratory indexes, the issue provides new evidences for the objectification of TCM syndromes in patients with dyslipidemia.
Lei
Yan
Y
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing. leiy999@163.com
Wang
Zhen-Hua
ZH
Liu
Jian-Gang
JG
D000328:Adult; D001809:Blood Viscosity; D002097:C-Reactive Protein / Q000378:metabolism; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods / Q000592:standards*; D008875:Middle Aged; D013577:Syndrome; D014463:Ultrasonography
D008055:Lipids; D006710:Homocysteine; D002097:C-Reactive Protein