title: Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development.
abstract: Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.
authors.affiliation: Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 project, College of Dentistry, Yonsei University, Seodaemoon-Gu, Seoul, Republic of Korea.
authors.forename: Kyoung-Won
authors.initials: KW
authors.lastname: Cho
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Hee-Seok
authors.initials: HS
authors.lastname: Gang
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Jung
mesh_terms: D000818:Animals; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D009055:Mouth / Q000196:embryology* / Q000201:enzymology; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D010159:Palate / Q000196:embryology / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010766:Phosphorylation; D014059:Tongue / Q000196:embryology / Q000201:enzymology; D014070:Tooth / Q000196:embryology / Q000201:enzymology
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D051059:PTEN Phosphohydrolase