Current status of antivascular therapy and targeted treatment in the clinic.
Antivascular and targeted therapy are now an integrated part of the treatment of myelogenous leukemias, GIST tumours, B-cell lymphomas and breast cancer. In various malignancies improved responses and prolongation of survival for several months is regularly reported. The progress in this field is relevant for hyperthermia. Heat has among other effects documented antivascular effects, and can be considered as one of the established methods in the field based on several randomised phase III studies. Hyperthermia should be considered for combination with other antiangiogenic agents.
Dahl
Olav
O
Institute of Medicine, University of Bergen Section of Oncology, Bergen, Norway. olav.dahl@helse-bergen.no
Borkamo
Erling Dahl
ED
Fluge
Oystein
O
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000628:therapy; D016032:Randomized Controlled Trials as Topic
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents