title: Fluorine in medicinal chemistry.
abstract: It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
authors.affiliation: The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Purser
authors.forename: Peter R
authors.initials: PR
authors.lastname: Moore
authors.forename: Steve
authors.initials: S
authors.lastname: Swallow
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated