title: Transrectal high-intensity focused ultrasound devices: a critical appraisal of the available evidence.
abstract: Developments in the technology applied to the field of minimally invasive surgery have led to the exploration of high-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer. Extensive research and continuous evolution have resulted in two commercially available HIFU devices: the Ablatherm and the Sonablate500. These devices are conceptually the same; however, specific technical differences exist. This paper reviews the clinical outcomes obtained with these devices, evaluates the quality of the evidence from the individual trials, and provides the results of a head-to-head comparison in terms of oncologic outcomes and complication rates.
authors.affiliation: Department of Urology, Academic Medical Center, University of Amsterdam, The Netherlands. tsakiris@in.gr
authors.forename: Peter
authors.initials: P
authors.lastname: Tsakiris
authors.forename: Stefan
authors.initials: S
authors.lastname: Thüroff
authors.forename: Jean
authors.initials: J
authors.lastname: de la Rosette
authors.forename: Christian
authors.initials: C
authors.lastname: Chaussy
mesh_terms: D019160:Endosonography / Q000295:instrumentation* / Q000706:statistics & numerical data*; D004867:Equipment Design; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012007:Rectum