title: Total synthesis of (+/-)-crinine via the regioselective Stille coupling and Diels-Alder reaction of 3,5-dibromo-2-pyrone.
abstract: The regioselective synthesis and Diels-Alder cycloaddition of 3-(3,4-methylenedioxyphenyl)-5-bromo-2-pyrone provided a new synthetic route to crinine. The vinyl bromide group can be used as a handle for further derivatization.
authors.affiliation: Department of Chemistry, Hanyang University, Seoul, Korea 133-791.
authors.forename: Nguyen Thanh
authors.initials: NT
authors.lastname: Tam
authors.forename: Cheon-Gyu
authors.initials: CG
authors.lastname: Cho
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C450850:3,5-dibromo-2-pyrone; D047151:Amaryllidaceae Alkaloids; D011753:Pyrones; C528221:crinine