title: Fragile X syndrome with anxiety disorder and exceptional verbal intelligence.
abstract: Fragile X syndrome (FXS) is often characterized by mental retardation. However, FXS is also associated with significant emotional and psychiatric problems, including anxiety, depression, attention difficulties, and learning disabilities in the presence of a normal IQ. This report describes a unique woman with the full mutation of FXS who has an exceptional profile of above-average intelligence combined with significant impairments due to anxiety and learning disability. Women with FXS can present primarily with learning and emotional problems, and clinicians should consider FXS in these women regardless of their IQ.
authors.affiliation: M.I.N.D. Institute, University of California-Davis Medical Center, Sacramento, California 95817, USA. kathleen.angkustsiri@ucdmc.ucdavis.edu
authors.forename: Kathleen
authors.initials: K
authors.lastname: Angkustsiri
authors.forename: Juthamas
authors.initials: J
authors.lastname: Wirojanan
authors.forename: Lesley J
authors.initials: LJ
authors.lastname: Deprey
authors.forename: Louise W
authors.initials: LW
authors.lastname: Gane
authors.forename: Randi J
authors.initials: RJ
authors.lastname: Hagerman
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014705:Verbal Behavior / Q000502:physiology*