[Immunosuppressive effects of glucocoriticoid].
Although glucocorticoid (GC) is widely used to treat a variety of autoimmune diseases, inflammatory diseases, allergic diseases and many, GC causes a number of significant side effects. Among them, bacterial, fungal and viral infections, based on immunosuppressive conditions induced by GC, are major complications of GC therapy. GC exerts its biological effects through binding to the GC receptor (GR), a ligand activated transcription factor(TF). Recent findings indicate that the crosstalk between GR and certain TF induced by cytokines or toll-like receptor (TLR) signaling, results in the modulation of genes targeted by these specific TF, including NF-kappaB, AP-1, STAT and IRF3. The modification of these TF by GR regulate the transcription of targeted genes involved in innate immunity, acquired immunity, allergy and inflammation, which results in the final outcome of the immune responses.
Tanaka
Yoshiya
Y
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents