title: Late-appearing Philadelphia chromosome in childhood acute myeloid leukemia.
abstract: A 3-year-old female was diagnosed with acute myeloid leukemia (AML-M2). The disease was refractory to various chemotherapeutic agents. Cytogenetic analysis revealed a clone with trisomy 8 at diagnosis that was replaced by a clone containing a t(11;15) and del(20q) by the end of the second induction. A new clone, characterized by a Philadelphia chromosome, with the minor BCR/ABL p190 transcript, emerged 14 months after diagnosis and remained to the end of disease course. The late occurrence of the Philadelphia chromosome in AML has been documented rarely in adults.
authors.affiliation: Department of Paediatrics, Division of Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Niketa
authors.initials: N
authors.lastname: Shah
authors.forename: Michael T
authors.initials: MT
authors.lastname: Leaker
authors.forename: Ikuko
authors.initials: I
authors.lastname: Teshima
authors.forename: Sylvain
authors.initials: S
authors.lastname: Baruchel
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdelhaleem
authors.forename: Charles C
authors.initials: CC
authors.lastname: Ye
mesh_terms: D001752:Blast Crisis; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010677:Philadelphia Chromosome; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D012333:RNA, Messenger; D016044:Fusion Proteins, bcr-abl