Dietary patterns and breast density in the Minnesota Breast Cancer Family Study.
OBJECTIVE
Whether dietary patterns, rather than single foods or nutrients, are associated with breast density is not known. We investigated this in the Minnesota Breast Cancer Family Study.


METHODS
Participants completed a 153-item food frequency questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. We used multivariate linear regression to quantify dietary pattern-breast density associations.


RESULTS
Among 3,147 women with dietary information, three dietary patterns emerged from principal components analysis: a fruit-vegetable-cereal pattern, a salad-sauce-pasta/grain pattern, and a meat-starch pattern. Among 1,286 women with breast density estimates, the fruit-vegetable-cereal and salad-sauce-pasta/grain patterns were inversely associated with percent breast density only in stratified analyses. The fruit-vegetable-cereal pattern was inversely associated with breast density among premenopausal women (beta = -0.13, p = 0.09; interaction p = 0.009) and current smokers, (beta = -0.30, p = 0.02; interaction p = 0.05), while the salad-sauce-pasta/grain was inversely associated with breast density among current smokers (beta = -0.27, p = 0.06; interaction p = 0.006).


CONCLUSIONS
Overall our results do not provide strong evidence for associations of dietary patterns with breast density. Suggestive inverse associations for the fruit-vegetable-cereal and salad-sauce-pasta/grain dietary patterns among smokers are consistent with previous reports and leave open the possibility that some dietary patterns influence breast density in population subsets. Nevertheless, these findings require confirmation, and their underlying reasons have yet to be clarified.
Tseng
Marilyn
M
Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA. m_tseng@fccc.edu
Vierkant
Robert A
RA
Kushi
Lawrence H
LH
Sellers
Thomas A
TA
Vachon
Celine M
CM
D000328:Adult; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D016014:Linear Models; D008327:Mammography; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012307:Risk Factors; D011795:Surveys and Questionnaires