Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa.
Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, 1- 8, including seven new compounds, gibberosenes A-G ( 2- 8). None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 1 significantly inhibited the accumulation of the pro-inflammatory COX-2 protein of the LPS-stimulated RAW264.7 macrophage cells.
Ahmed
Atallah F
AF
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Replublic of China.
Wen
Zhi-Hong
ZH
Su
Jui-Hsin
JH
Hsieh
Ya-Ting
YT
Wu
Yang-Chang
YC
Hu
Wan-Ping
WP
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002268:Carboxypeptidases; D043422:Carboxypeptidases A / Q000187:drug effects / Q000378:metabolism; D003198:Computer Simulation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D013624:Taiwan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D008070:Lipopolysaccharides; D002268:Carboxypeptidases; C115512:Cpxm2 protein, mouse; D043422:Carboxypeptidases A; D010100:Oxygen