Polymorphism of the interleukin-10 gene in polycystic ovary syndrome.
Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. We aimed to evaluate the IL-10 gene polymorphisms in polycystic ovary syndrome (PCOS) and control subjects. Ninety-one young women with PCOS and 74 healthy control women were included in our study. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin and IL-10 gene polymorphism genetic analysis and carotid intimae media thickness (CIMT) were measured. The genotype and allele frequencies showed similar ratios between both the control and the patient group. The AA and AG genotypes in IL-10 polymorphism seemed to be relatively high, but statistically no significant difference has been detected in GG genotype. Our results show that IL-10 gene polymorphism of PCOS patients has no effect on inflammatory markers, metabolic parameters (fasting insulin, fasting glucose, HOMA-IR), carotid intimae media thickness and Ferriman- Gallwey scoring. These data will be different in PCOS patients with different ethnical origin.
Karadeniz
M
M
Division of Internal Disease, Department of Endocrinology and Metabolism, Ege University, Izmir, Turkey. muammerkaradenis@gmail.com
Erdogan
M
M
Zengi
A
A
Tamsel
S
S
Berdeli
A
A
Saygili
F
F
Yilmaz
C
C
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002339:Carotid Arteries / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics; D005215:Fasting / Q000097:blood; D005260:Female; D005787:Gene Frequency; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D016753:Interleukin-10 / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017539:Tunica Intima / Q000378:metabolism
D015415:Biomarkers; D001786:Blood Glucose; C508609:IL10 protein, human; D018836:Inflammation Mediators; D007328:Insulin; D016753:Interleukin-10