title: [Diagnostic spectrum of synovitis].
abstract: This review will suggest an algorithm for standardised histopathological diagnosis of synovial biopsies and synovectomy specimens. In principal, changes of the synovial membrane can be inflammatory or non-inflammatory. To the latter group belong some benign tumors, such as tenosynovial giant cell tumor, lipoma or synovial chondromatosis. Rare non-inflammatory changes are the group of storage diseases. Inflammatory synovial diseases can be differentiated into crystal-induced arthropathy, such as gout and pseudogout, granulomatous diseases, such as tuberculosis, sarcoidosis and foreign body reactions and into the large group of non-granulomatous synovitis. This last group is by far the most common and often causes difficulties in assigning the histopathological findings to a definite diagnosis. Therefore, the synovitis score should be applied in these cases as a diagnostic means, leading to the diagnosis of low-grade synovitis (which is associated with degenerative and posttraumatic arthropathies) or high-grade synovitis (associated with rheumatic diseases), the sensitivity and specificity being 60.5% and 95.5%, respectively. In detritus synovitis the synovitis score is not applicable.
authors.affiliation: Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Strasse 18+20, 54296, Trier, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Knöss
authors.forename: M
authors.initials: M
authors.lastname: Knöss
authors.forename: M
authors.initials: M
authors.lastname: Otto
authors.forename: J
authors.initials: J
authors.lastname: Kriegsmann
authors.forename: M G
authors.initials: MG
authors.lastname: Krukemeyer
authors.forename: V
authors.initials: V
authors.lastname: Krenn
mesh_terms: D000465:Algorithms; D003937:Diagnosis, Differential; D006801:Humans; D013585:Synovitis / Q000145:classification* / Q000473:pathology*