title: [Correlation of tomographic findings with pulmonary function parameters in nonsmoking patients with idiopathic pulmonary fibrosis].
abstract: OBJECTIVE
  To correlate tomographic findings with pulmonary function parameters in patients with idiopathic pulmonary fibrosis (IPF).
  
  
  METHODS
  A cross-sectional study was carried out, in which 30 nonsmoking patients with IPF were evaluated. Using a semiquantitative scoring system, the following high-resolution computerized tomography (HRCT) findings were quantified: total interstitial disease (TID), reticular abnormality/honeycombing, and ground-glass opacity (GGO). The functional variables were measured by spirometry, forced oscillation technique (FOT), helium dilution method, as well as the single-breath method of measuring diffusion capacity of the lung for carbon monoxide (DLCO).
  
  
  RESULTS
  Of the 30 patients studied, 18 were female, and 12 were male, with a mean age of 70.9 years. We found that TID and reticular abnormality and honeycombing correlated significantly (negative correlations) with the measurements of forced vital capacity (FVC), total lung capacity (TLC), DLCO, and dynamic respiratory compliance were found, as well as that GGO correlated significantly (and positively) with residual volume/TLC. The ratio of forced expiratory flow between 25 and 75% of FVC to FVC (FEF(25-75%)/FVC) correlated positively with TID, reticular abnormality/honeycombing, and GGO.
  
  
  CONCLUSIONS
  In IPF patients, the measurements of volume, diffusion, and dynamic compliance are the physiological variables which best reflect the extent of the interstitial disease on HRCT scans.
authors.affiliation: Programa de Pós-graduação, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. phel.lop@uol.com.br
authors.forename: Agnaldo José
authors.initials: AJ
authors.lastname: Lopes
authors.forename: Domenico
authors.initials: D
authors.lastname: Capone
authors.forename: Roberto
authors.initials: R
authors.lastname: Mogami
authors.forename: Daniel Leme da
authors.initials: DL
authors.lastname: Cunha
authors.forename: Pedro Lopes de
authors.initials: PL
authors.lastname: Melo
authors.forename: José Manoel
authors.initials: JM
authors.lastname: Jansen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002248:Carbon Monoxide / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011653:Pulmonary Diffusing Capacity / Q000502:physiology; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012907:Smoking; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D002248:Carbon Monoxide