Monster protein controls calcium entry and fights infection.
Sustained calcium signaling in T cells is critical for development and activation. In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection.
Radermacher
Amy N
AN
Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Crabtree
Gerald R
GR
D000818:Animals; D020013:Calcium Signaling / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology
C489572:Ahnak protein, mouse; D008565:Membrane Proteins; D009363:Neoplasm Proteins