Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity.
According to most authors, dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) represent the adult and juvenile forms, respectively, of the same disease entity, as evidenced by similar morphology, an identical chromosomal translocation, and CD34 positivity. It has been shown that DFSP and nuchal-type fibroma (NTF) (which is also CD34-positive) are related lesions, and that there might possibly be a continuum between the two. In addition, NTF exhibits CD99 positivity. It was therefore, hypothesized that both DFSP and GCF would show similar immunopositivity for CD99. Archives of pathology at several institutions were searched for DFSP and GCF tissue blocks. A total of 29 DFSP and 5 GCF were analyzed by immunohistochemistry for expression of CD99. Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant.
Diwan
A Hafeez
AH
Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. ahdiwan@mdanderson.org
Skelton
Henry G
HG
Horenstein
Marcelo G
MG
Kelly
David R
DR
Barrett
Terry L
TL
Bussian
Anne H
AH
Sanders
Deborah Y
DY
Lazar
Alexander J F
AJ
Prieto
Victor G
VG
Smith
Kathleen J
KJ
D000071443:12E7 Antigen; D015703:Antigens, CD / Q000378:metabolism*; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018223:Dermatofibrosarcoma / Q000276:immunology* / Q000473:pathology; D005870:Giant Cell Tumors / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
D000071443:12E7 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules