Dietary patterns and the risk of Barrett's esophagus.
The objective of this study was to examine the associations between dietary patterns and the risk of Barrett's esophagus, a precursor to esophageal adenocarcinoma. The authors conducted a case-control study within the Kaiser Permanente Northern California population between 2002 and 2005. Patients with a new diagnosis of Barrett's esophagus (n = 296 cases) were matched to persons with gastroesophageal reflux disease (n = 308) without Barrett's esophagus and to population controls (n = 309). Dietary information was obtained from a validated, 110-item food frequency questionnaire. A principal component analysis was used to identify major dietary patterns. Two major dietary patterns were "Western" (high in fast food and meat) and "health-conscious" (high in fruits, vegetables, and nonfried fish). When cases and population controls were compared, strong adherence to the health-conscious dietary pattern was inversely associated with Barrett's esophagus (odds ratio = 0.35, 95% confidence interval: 0.20, 0.64; fourth vs. first quartile comparison). In contrast, data suggested an adverse effect of the Western dietary pattern on the risk of Barrett's esophagus, although no dose-effect relation was found. Results suggest strong associations between a diet rich in fruits and vegetables and the risk of Barrett's esophagus.
Kubo
Ai
A
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Levin
T R
TR
Block
Gladys
G
Rumore
Gregory J
GJ
Quesenberry
Charles P
CP
Buffler
Patricia
P
Corley
Douglas A
DA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000453:epidemiology*; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires