Anti-allergic prenylated flavonoids from the roots of Sophora flavescens.
The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.
Quan
Wenying
W
Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
Lee
Hee Ju
HJ
Kim
Chul Young
CY
Noh
Chu Won
CW
Um
Byung Hun
BH
Oak
Min-Ho
MH
Kim
Kyeong-Man
KM
D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D015471:Leukemia, Basophilic, Acute; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D029909:Sophora / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
D018926:Anti-Allergic Agents; D005419:Flavonoids; D001619:beta-N-Acetylhexosaminidases