title: [Long-term results after liver transplantation].
abstract: Liver transplantation has been reported to reach excellent results for selected indications. We analysed the results of liver transplantation in our centre over a period of 23 years, with a total of 2,114 consecutive liver transplants in 1,773 patients (eras I-III 5.5 years each, era IV 6.5 years). Overall 20-year survival after liver transplantation was 29.8%. The most frequent leading causes of death were infections of various origins (30%), tumour recurrence (14.2%), and pneumonia (8.4%). The most frequent leading causes for graft loss were infection of various origins (19.6%), initial nonfunction of the graft (14.6%), and tumour recurrence (9.6%). Both long-term patient and graft survival were significantly better after primary liver transplantation than after first retransplantation (P<0.001). Patient and graft long-term survival improved significantly across all four consecutive eras (P<0.001). In era IV, the most recent, 5-year patient survival reached 96% for PBC, 89.4% for PSC, 78.5% for biliary atresia, 70% for acute liver failure, 69.1% for HBV-related cirrhosis, 61.3% for hepatocellular carcinoma, and 56% for HCV-related cirrhosis.
authors.affiliation: Allgemein-, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover. Schrem.Harald@mh-hannover.de
authors.forename: H
authors.initials: H
authors.lastname: Schrem
authors.forename: N
authors.initials: N
authors.lastname: Till
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.forename: H
authors.initials: H
authors.lastname: Bektas
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
authors.forename: C P
authors.initials: CP
authors.lastname: Strassburg
authors.forename: J
authors.initials: J
authors.lastname: Klempnauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D004059:Diffusion of Innovation; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006085:Graft Survival; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000401:mortality