Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network.
Kaposi's sarcoma-associated herpes virus (KSHV), the causative agent of several neoplasms, has recently been shown to encode 12 microRNAs. mir-155 is a host-encoded microRNA associated with lymphomagenesis. Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis.
McClure
Lydia V
LV
Molecular Genetics and Microbiology, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0162, USA.
Sullivan
Christopher S
CS
D002460:Cell Line; D015972:Gene Expression Regulation, Neoplastic; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins