Transmission of type 1 diabetes by bone marrow transplantation: a case report.
T1D after BMT constitutes a human model of autoimmune disease transmission. This case report refers to T1D onset after allogeneic HLA-matched BMT in a six-yr-old recipient affected by aplastic anemia. The donor was his sister who had T1D. The recipient had a complication free course apart from grade 1 acute GVHD, which was resolved spontaneously. With the predictive value and significance of T1D-associated autoantibodies, we tried to consolidate the T1D transfer possibility based on our patient characteristics and a literature review.
Mellouli
Fethi
F
Service d'Immuno-Hématologie pédiatrique, Centre National de Greffe de Moelle Osseuse, Tunis, Tunisia. melloulif@yahoo.fr
Ksouri
Habib
H
Torjmen
Lamia
L
Abdelkefi
Abderrahman
A
Ladeb
Saloua
S
Ben Othman
Tarek
T
Ben Hassen
Assia
A
Béjaoui
Mohamed
M
D000741:Anemia, Aplastic / Q000601:surgery; D001323:Autoantibodies / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D008297:Male; D014019:Tissue Donors
D001323:Autoantibodies