[Osteomyelitis of the jaw in breast cancer patients receiving bisphosphonate therapy].
Osteonecrosis of the jaw is a severe new complication in cancer patients with bone metastases receiving bisphosphonate. Currently, there is no effective treatment for bisphosphonate-related osteonecrosis of the jaw, and the pathogenesis of this complication has not been completely elucidated. It has been shown that a potential risk factor for the complication is dentoalveolar trauma including extraction of teeth during bisphosphonate therapy. Attention should be paid to dental care in patients prior to the initiation of bisphosphonate therapy, and extraction of teeth during bisphosphonate therapy should be avoided to prevent this complication. Therefore, the communication between general physicians prescribing bisphosphonate and dentists is important.
Tomihara
Kei
K
Dept. of Oral Surgery, Sapporo Medical University School of Medicine.
Nagai
Itaru
I
Yamaguchi
Akira
A
Miyazaki
Akihiro
A
Dehari
Hironari
H
Abe
Masato
M
Nakamori
Kenji
K
Komai
Kiyoto
K
Nakai
Mitsuyoshi
M
Hiratsuka
Hiroyoshi
H
D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy*; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology*; D010019:Osteomyelitis / Q000139:chemically induced* / Q000473:pathology*; D011859:Radiography
D004164:Diphosphonates