title: The risk of newly diagnosed asthma in migraineurs with or without previous triptan prescriptions.
abstract: BACKGROUND
  Previous observational studies reported an increased prevalence of asthma in migraine patients. Whether triptans affect the asthma risk has not yet been explored in an epidemiological study.
  
  
  OBJECTIVE
  To estimate the risk of newly diagnosed asthma in patients with a general practitioner-diagnosed migraine in the UK between 1994 and 2001.
  
  
  METHODS
  A population-based follow-up study and a nested case-control analysis were conducted using the General Practice Research Database.
  
  
  RESULTS
  The study encompassed 51,688 migraineurs and the same number of matched controls. In the follow-up analysis, the relative risk of developing asthma in migraineurs compared with non-migraineurs was 1.3 (95% confidence interval [CI] 1.1-1.4). In the nested case-control analysis, the adjusted odds ratio for asthma in migraineurs overall was 1.17 (95% CI 1.01-1.35), and for those with a recent triptan prescription 1.12 (95% CI 0.65-1.94).
  
  
  CONCLUSIONS
  The risk of developing asthma was not materially altered for patients with a general practitioner-recorded migraine diagnosis, regardless of triptan use.
authors.affiliation: Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
authors.forename: Claudia
authors.initials: C
authors.lastname: Becker
authors.forename: Gunnar P
authors.initials: GP
authors.lastname: Brobert
authors.forename: Per M
authors.initials: PM
authors.lastname: Almqvist
authors.forename: Saga
authors.initials: S
authors.lastname: Johansson
authors.forename: Susan S
authors.initials: SS
authors.lastname: Jick
authors.forename: Christoph R
authors.initials: CR
authors.lastname: Meier
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy*; D012307:Risk Factors; D014363:Tryptamines / Q000009:adverse effects*
chemical_list: D014363:Tryptamines