Correlation between oxidation potentials and inhibitory effects on Epstein-Barr virus activation of flavonoids.
The oxidation potentials of fifteen flavonoids in phosphate buffer at pH 7.2 were determined by cyclic voltammetry. A good correlation was found between these oxidation potentials and the ability of flavonoids to inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Furthermore, multiple regression analysis revealed that the solvent-accessible surface area (SASA) was a useful parameter for estimating the inhibitory effects of flavonoids on EBV-EA activation.
Koyama
Junko
J
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. j-koyama@kobepharma-u.ac.jp
Morita
Izumi
I
Kobayashi
Norihiro
N
Konoshima
Takao
T
Takasaki
Midori
M
Osakai
Toshiyuki
T
Tokuda
Harukuni
H
D004563:Electrochemistry; D005419:Flavonoids / Q000493:pharmacokinetics*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D010084:Oxidation-Reduction
D005419:Flavonoids