title: Genetic background and the dilemma of translating mouse studies to humans.
abstract: C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.
authors.affiliation: Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. juan_rivera@nih.gov
authors.forename: Juan
authors.initials: J
authors.lastname: Rivera
authors.forename: Lino
authors.initials: L
authors.lastname: Tessarollo
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D005823:Genetics; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*