Toll-like receptors and airway inflammation.
The respiratory tract opens to the external environment at the oral side edge, and the other edge of the respiratory tract connects to the closed space (alveoli), and so to preserve the sterility in the terminal respiratory tract is critical for protection against pathogens. The recognition machinery for the invasion of microbes is indispensable for the preservation of the sterility in the lungs. Our general understanding of how microbes are recognized by the innate immune system has increased considerably over the past several years, and the contribution of Toll-Like Receptors (TLRs) to innate immunity is now well documented. In the meantime, it has come to understand that many inflammatory processes may depend on TLR signaling, it has been considered to be involved in the pathogenesis of airway inflammatory diseases such as airway infections, bronchial asthma, and occupational airway diseases. In this review, we focus on physiological roles of TLRs in defense mechanisms of the airways, and pathophysiological roles on airway diseases.
Gon
Yasuhiro
Y
Division of Molecular Cell Immunology and Allergology, Department of Advanced Medical Research Center, Nihon University Graduate School of Medicine, Tokyo, Japan. gon@med.nihon-u.ac.jp
D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology; D002244:Carbon / Q000633:toxicity; D060729:Coal Ash; D014644:Genetic Variation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D008070:Lipopolysaccharides / Q000633:toxicity; D052638:Particulate Matter / Q000633:toxicity; D020545:Respiratory Mucosa / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D012140:Respiratory Tract Diseases / Q000150:complications / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
D060729:Coal Ash; D008070:Lipopolysaccharides; D052638:Particulate Matter; D051193:Toll-Like Receptors; D002244:Carbon