title: Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates.
abstract: Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby demonstrating the utility of nucleotidylyltransferases to catalyze the synthesis of sugar nucleotides with potential applications in lipopolysaccharide and lipoglycopeptide biosynthesis.
authors.affiliation: College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, CanadaB3H 3J5.
authors.forename: Malcolm P
authors.initials: MP
authors.lastname: Huestis
authors.forename: Gaia A
authors.initials: GA
authors.lastname: Aish
authors.forename: Joseph P M
authors.initials: JP
authors.lastname: Hui
authors.forename: Evelyn C
authors.initials: EC
authors.lastname: Soo
authors.forename: David L
authors.initials: DL
authors.lastname: Jakeman
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009711:Nucleotides / Q000138:chemical synthesis*; D009713:Nucleotidyltransferases / Q000737:chemistry / Q000378:metabolism*; D017433:Protein Structure, Secondary; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D012210:Rhamnose / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity; D013403:Sugar Phosphates; D013942:Thymine Nucleotides / Q000737:chemistry / Q000378:metabolism
chemical_list: D009711:Nucleotides; D013403:Sugar Phosphates; D013942:Thymine Nucleotides; C103522:deoxythymidine diphosphate-glucose; D009713:Nucleotidyltransferases; D005947:Glucose; D012210:Rhamnose