[New therapeutic strategy for cancer targeting the hedgehog signaling pathway].
The hedgehog (Hh) signaling pathway was originally found as an organizer in embryonic development. The pathway is now implicated in the development of various tumors. Recently, it has been reported that the pathway activation is resulted from aberrant expression of the ligand, Sonic Hh (Shh), in pancreatic cancer and breast cancer. Here we developed a new strategy to control the activation of the Hh signaling pathway in cancer cells, which have ectopic and ligand dependent activation of the Hh signaling pathway. Our strategy may contribute to the development of a new cancer treatment.
Nakamura
Masafumi
M
Dept. of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University.
Kubo
Makoto
M
Nagai
Shuntaro
S
Yamaguchi
Koji
K
Tanaka
Masao
M
Katano
Mitsuo
M
D000906:Antibodies / Q000276:immunology; D045744:Cell Line, Tumor; D017930:Genes, Reporter / Q000235:genetics; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D000071676:Zinc Finger Protein GLI1
D000906:Antibodies; C400551:GLI1 protein, human; D053823:Hedgehog Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1