title: Narrative speech production: an fMRI study using continuous arterial spin labeling.
abstract: Functional magnetic resonance imaging (fMRI) with continuous arterial spin labeling (CASL) was employed to monitor brain activation during narrative production of a semi-structured speech sample in healthy young adults. Subjects were asked to describe a wordless children's picture story. Significant activations were found in bilateral prefrontal and left temporal-parietal regions during narrative production relative to description of a single picture and relative to viewing the wordless picture story while producing a nonsense word. We conclude that inferior frontal cortex serves as a top-down organizational resource for narrative production and demonstrate the feasibility of collecting extended speech samples using CASL perfusion fMRI.
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Troiani
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Fernández-Seara
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
authors.forename: Ze
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
authors.forename: Sherry
authors.initials: S
authors.lastname: Ash
authors.affiliation: Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA. Electronic address: mgrossma@mail.med.upenn.edu.
authors.forename: Murray
authors.initials: M
authors.lastname: Grossman
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010296:Parietal Lobe / Q000502:physiology*; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*