Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes.
The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.
Tsuda
Tatsuya
T
Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Ishikawa
Chika
C
Konishi
Hiroe
H
Hayashi
Yoshiaki
Y
Nakagawa
Noboru
N
Matsuki
Masato
M
Mizutani
Hitoshi
H
Yamanishi
Kiyofumi
K
D002478:Cells, Cultured; D017291:Clarithromycin / Q000737:chemistry / Q000494:pharmacology; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects; D004917:Erythromycin / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D016209:Interleukin-8 / Q000096:biosynthesis*; D015603:Keratinocytes / Q000187:drug effects* / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology*; D044464:Receptor, PAR-2 / Q000187:drug effects* / Q000378:metabolism*; D015575:Roxithromycin / Q000737:chemistry / Q000494:pharmacology
D053583:Interleukin-1beta; D016209:Interleukin-8; D018942:Macrolides; D044464:Receptor, PAR-2; D015575:Roxithromycin; D004917:Erythromycin; D017291:Clarithromycin