Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.
This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the issues associated with the treatment of hospital infections caused by Gram-negative bacteria. The group discussed the severe clinical problems arising from the emergence of antibiotic resistance in these bacteria and the lack of new antibacterial agents to challenge the threat. The discovery of new drugs active against hospital-acquired Gram-negative bacteria is essential to prevent a future medical and social catastrophe. An important strategy to promote drug discovery will be the development of focused cooperations between academic institutions and small pharmaceutical companies.
Chopra
Ian
I
Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK. i.chopra@leeds.ac.uk
Schofield
Christopher
C
Everett
Martin
M
O'Neill
Alex
A
Miller
Keith
K
Wilcox
Mark
M
Frère
Jean-Marie
JM
Dawson
Mike
M
Czaplewski
Lloyd
L
Urleb
Uros
U
Courvalin
Patrice
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans
D000900:Anti-Bacterial Agents