[Dysfunction of axonal transport in neuropathies and motor neuron diseases].
Sensory neurons and motor neurons are particularly vulnerable to axonal transport defects due to the length of their axons. Several mutations have recently been identified in genes coding for cytoskeletal or motor proteins as causative factors in various neurodegenerative diseases. This review synthesizes the main defects found in inherited peripheral neuropathies and in motor neuron diseases as well as in mouse models of these disorders.
Millecamps
Stéphanie
S
CNRS UMR7091, Hôpital de la Pitié-Salpêtrière, 83 boulevard de l'Hôpital, Paris, France.
Julien
Jean-Pierre
JP
D001370:Axonal Transport / Q000502:physiology*; D001692:Biological Transport; D006801:Humans; D016472:Motor Neuron Disease / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D009422:Nervous System Diseases / Q000503:physiopathology*
D009419:Nerve Tissue Proteins