New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.
A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.
Wright
Casey W
CW
Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Duckett
Colin S
CS
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000502:physiology*; D016259:Genes, myc / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051034:Inhibitor of Apoptosis Proteins; C079439:MXD1 protein, human; D012097:Repressor Proteins