title: Physiological changes in tissues denervated by spinal cord injury tissues and possible effects on wound healing.
abstract: There are many metabolic and physiological changes that happen to the tissues below the level of a spinal cord injury. These deficits are examined in relation to the series of events that has to take place for wound healing - the "wound healing cascade". The conclusion is that every step of the wound healing process is impaired by the physiological deficits inherent post-spinal cord injury. This may explain, in part, why pressure ulcers on these patients are so difficult to close and to maintain closed.
authors.affiliation: Span-America, 70 Commerce Centre, Greenville, SC, USA. lrappl@spanamerica.com
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Rappl
mesh_terms: D001510:Bed Rest / Q000009:adverse effects; D001777:Blood Coagulation / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003094:Collagen / Q000502:physiology; D019317:Evidence-Based Medicine; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D006025:Glycosaminoglycans / Q000502:physiology; D006801:Humans; D007249:Inflammation; D008833:Microcirculation; D010100:Oxygen / Q000502:physiology; D003668:Pressure Ulcer / Q000209:etiology* / Q000517:prevention & control; D011941:Receptors, Adrenergic; D012008:Recurrence; D012307:Risk Factors; D017592:Skin Care; D013119:Spinal Cord Injuries / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D005353:Fibronectins; D006025:Glycosaminoglycans; D011941:Receptors, Adrenergic; D003094:Collagen; D010100:Oxygen