[Carboplatin and CPT-11 chemotherapy in a hemodialysis patient with small-cell lung cancer].
We administered a dose-down chemotherapy, which was a combination of carboplatin 100 mg/body (AUC 3.0, day 1) and CPT-11 30 mg/m2 (day 1, day 15) to the patient with a poor performance status of extensive small-cell lung cancer with renal failure. Hemodialysis was performed two hours after the chemotherapy. We measured plasma levels of total-platinum and CPT-11 and metabolic products (SN-38) after the hemodialysis. The results of pharmacokinetic study showed a high level collection of total-platinum caused by carboplatin and SN-38, and that was caused by CPT-11 in the blood. Although the grade 3 of granulocytopenia was found, the decrease in tumor marker and an improvement of the ADL were confirmed. It thought that this chemotherapeutic regimen was effective for small-cell lung cancer with renal failure undergoing hemodialysis. Further study is needed for a selection of suitable chemotherapeutic regimens, an optimal dosage of each drug and timing of hemodialysis.
Koshiishi
Haruya
H
Dept. of Surgery, Tokyo Metropolitan Otsuka Hospital.
Yasui
Toshiyuki
T
Takahashi
Eisuke
E
Kakimoto
Yoshiki
Y
Okamura
Takashi
T
Minami
Tomohito
T
Baba
Michiko
M
Hayashi
Naganobu
N
Koshiishi
Yoshihiko
Y
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D016190:Carboplatin / Q000097:blood / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D000077146:Irinotecan; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed
D000077146:Irinotecan; D016190:Carboplatin; D002166:Camptothecin