title: www.rnaworkbench.com: A new program for analyzing RNA interference.
abstract: RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.
authors.affiliation: ANF DATA (Siemens), Herspická 5, 639 00 Brno, Czech Republic.
authors.forename: Radka Svobodová
authors.initials: RS
authors.lastname: Vareková
authors.forename: Ivan
authors.initials: I
authors.lastname: Bradác
authors.forename: Martin
authors.initials: M
authors.lastname: Plchút
authors.forename: Michal
authors.initials: M
authors.lastname: Skrdla
authors.forename: Michael
authors.initials: M
authors.lastname: Wacenovsky
authors.forename: Helmuth
authors.initials: H
authors.lastname: Mahr
authors.forename: Georg
authors.initials: G
authors.lastname: Mayer
authors.forename: Herbert
authors.initials: H
authors.lastname: Tanner
authors.forename: Hermann
authors.initials: H
authors.lastname: Brugger
authors.forename: Josef
authors.initials: J
authors.lastname: Withalm
authors.forename: Peter
authors.initials: P
authors.lastname: Lederer
authors.forename: Heinrich
authors.initials: H
authors.lastname: Huber
authors.forename: Gerhard
authors.initials: G
authors.lastname: Gierlinger
authors.forename: Ronald
authors.initials: R
authors.lastname: Graf
authors.forename: Hakim
authors.initials: H
authors.lastname: Tafer
authors.forename: Ivo
authors.initials: I
authors.lastname: Hofacker
authors.forename: Peter
authors.initials: P
authors.lastname: Schuster
authors.forename: Martin
authors.initials: M
authors.lastname: Polcík
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D018390:Gene Targeting / Q000379:methods*; D008969:Molecular Sequence Data; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software
chemical_list: D034741:RNA, Small Interfering