Major uropathogenic Escherichia coli strain isolated in the northwest of England identified by multilocus sequence typing.
A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.
Lau
Siu Ha
SH
Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building 1, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom.
Reddy
Suganya
S
Cheesbrough
John
J
Bolton
Frederick J
FJ
Willshaw
Geraldine
G
Cheasty
Tom
T
Fox
Andrew J
AJ
Upton
Mathew
M
D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology; D018550:Cephalosporin Resistance; D004739:England / Q000453:epidemiology; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D017422:Sequence Analysis, DNA; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology; D014556:Urine / Q000382:microbiology
D029968:Escherichia coli Proteins