Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle.
AMP-activated protein kinase (AMPK) is master regulator of energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways. AMPK is activated by external metabolic stresses and subsequently orchestrates a complex downstream signaling cascade that mobilizes the cell for efficient energy production. AMPK has emerged as a key kinase driving lipid oxidation in skeletal muscle, and this function has important implications for exercise adaptations as well as metabolic defects associated with obesity.
Osler
Megan E
ME
Karolinska Institute, Department of Molecular Medicine and Surgery, Integrative Physiology, von Eulers väg 4, 4 SE-171 77 Stockholm, Sweden.
Zierath
Juleen R
JR
D055372:AMP-Activated Protein Kinases; D000818:Animals; D015444:Exercise / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009154:Mutation; D010084:Oxidation-Reduction; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
D005227:Fatty Acids; D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases