Study of rotating permanent magnetic field to treat steroid-induced osteonecrosis of femoral head.
Sixty New Zealand rabbit models with steroid-induced necrosis of femoral head were exposed to a rotating permanent magnetic field (RPMF) (group A1-2 h/d for one month and group A2-2 h/d for two months), and the changes of femoral head, blood viscosity, serum cholesterol, triglyceride, and pressure within the hip joint cavity were measured and statistically analysed compared to that of control group (B1 and B2) and sham group (C1 and C2). After RPMF treatment, the osteogenesis regeneration of the necrotic femoral head was markedly improved, as was shown by micro-CT. Blood viscosity, serum cholesterol, triglyceride, and pressure in the hip joint cavity were found significantly reduced. RPMF could affect various critical aspects in the course of femoral head necrosis, which will be a promising measure in the prevention and treatment of steroid-induced necrosis of femoral head, especially in the early stage.
Pan
Xiaohua
X
Department of Orthopedics, The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China.
Xiao
Deming
D
Zhang
Xiaoyun
X
Huang
YuanShuai
Y
Lin
Bowen
B
D000818:Animals; D001809:Blood Viscosity; D001861:Bone Regeneration / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005270:Femur Head / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D005938:Glucocorticoids / Q000009:adverse effects*; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D011239:Prednisolone / Q000009:adverse effects*; D011312:Pressure; D011817:Rabbits; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D005938:Glucocorticoids; D014280:Triglycerides; D002784:Cholesterol; D011239:Prednisolone