Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: a facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy.
Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO2(Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spin-orbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.
Lai
Chih-Wei
CW
Department of Chemistry, National Taiwan University, Taipei, Taiwan 106, ROC.
Wang
Yu-Hsiu
YH
Lai
Cheng-Hsuan
CH
Yang
Meng-Ju
MJ
Chen
Chun-Yen
CY
Chou
Pi-Tai
PT
Chan
Chi-Shun
CS
Chi
Yun
Y
Chen
Yu-Chun
YC
Hsiao
Jong-Kai
JK
D017209:Apoptosis / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media; D052203:Ferrosoferric Oxide; D006367:HeLa Cells; D006801:Humans; D007495:Iridium; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D012822:Silicon Dioxide; D026082:Singlet Oxygen; D013053:Spectrophotometry
D003287:Contrast Media; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D007495:Iridium; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide