title: Xerostomia: causes and treatment.
abstract: When reduced salivary flow causes perpetual dry and sticky mucosa or sticky, stringy saliva, it becomes xerostomia-not a disease, but a symptom. Up to 30% of various populations self-report dry mouth (xerostomia) or have proven low salivary flow rates. Saliva is necessary for digestion and dental health, and it may have yet-unidentified immunological roles in humans. Xerostomia can lead to digestive problems, weight loss, and accelerated dental decay. Medications-several hundred of them-can cause or exacerbate xerostomia. Cancer, autoimmune diseases, and bone marrow transplants are associated with xerostomia. Including a dentist on the treatment team is essential for residents with dry mouth. As xerostomia progresses, they should shift focus primarily to prevention, maintenance, oral comfort, and emergency treatment. In all stages, they should keep treatment noninvasive if possible.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Jeanette Y
authors.initials: JY
authors.lastname: Wick
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D010862:Pilocarpine / Q000627:therapeutic use; D011812:Quinuclidines / Q000627:therapeutic use; D012463:Saliva / Q000378:metabolism; D013876:Thiophenes / Q000627:therapeutic use; D014987:Xerostomia / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*
chemical_list: D011812:Quinuclidines; D013876:Thiophenes; D010862:Pilocarpine; C059240:cevimeline