title: Towards the development of a broadly protective group a streptococcal vaccine based on the Lipid-Core Peptide system.
abstract: Preclinical studies carried out over the last seven years by our group have focused on the development of a group A streptococcal (GAS) vaccine based on the antiphagocytic bacterial surface M protein using the Lipid-Core Peptide (LCP) system. This synthetic peptide vaccine delivery system has several advantages over other delivery systems including its self-adjuvanting properties and the ability to incorporate multiple peptide epitopes into a single vaccine. This review describes various vaccine delivery strategies including the LCP system, highlighting its functional properties and applications in vaccine research using data obtained from various LCP-based GAS vaccine candidates evaluated in murine models.
authors.affiliation: The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Colleen.Olive@qimr.edu.au
authors.forename: C
authors.initials: C
authors.lastname: Olive
authors.forename: P M
authors.initials: PM
authors.lastname: Moyle
authors.forename: I
authors.initials: I
authors.lastname: Toth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry; D002352:Carrier Proteins / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D022541:Streptococcal Vaccines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry*; D013297:Streptococcus pyogenes / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D008055:Lipids; D010455:Peptides; D022541:Streptococcal Vaccines; D014614:Vaccines, Synthetic; C014689:streptococcal M protein