Transient receptor potential vanilloid receptor-1 confers heat resistance to male germ cells.
Testicular hyperthermia in mice lacking transient receptor potential vanilloid receptor-1 results in a much more rapid and massive germ cell depletion from the seminiferous tubules than in wild-type animals, indicating that this receptor protects germ cells against heat stress.
Mizrak
Sefika Canan
SC
Fertility Laboratory, Center for Reproductive Medicine, Academic Medical Center, Amsterdam, The Netherlands. s.c.mizrak@amc.uva.nl
van Dissel-Emiliani
Federica M F
FM
D000818:Animals; D002478:Cells, Cultured; D018869:Heat-Shock Response / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013094:Spermatozoa / Q000166:cytology* / Q000502:physiology*; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism*
D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse