A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder.
OBJECTIVE
The PDLIM5 gene is known to interact specifically with the N-type calcium channel alpha-1B subunit and protein kinase C epsilon and is critical for rapid, efficient potentiation of the calcium channel activation by protein kinase C in neurons. Increasing amounts of data suggested that PDLIM5 might be involved in the pathophysiology of major depressive disorder (MDD). The aim of this study was to examine whether genetic variations in the human PDLIM5 gene might contribute to the liability to develop MDD.


METHODS
We undertook a gene-based association analysis of single nucleotide polymorphisms (SNPs). Three SNPs (rs10008257, rs2433320 and rs2452600) were identified in the PDLIM5 gene and genotyped in patients diagnosed with recurrent MDD and in matched control subjects.


RESULTS
We observed significant allele (p = 0.007) and genotype (p = 0.007) association with rs2433320, and the G allele of rs2433320 was significantly overrepresented in control subjects in comparison with MDD patients.


CONCLUSIONS
These results support the hypothesis of a protective effect for the G allele of rs2433320 in the PDLIM5 gene in recurrent MDD.
Liu
Zhongchun
Z
Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, China.
Liu
Wanhong
W
Xiao
Zheman
Z
Wang
Gaohua
G
Yin
Shijin
S
Zhu
Fan
F
Wang
Huiling
H
Cheng
Jin
J
Wang
Xiaoping
X
He
Xiaohua
X
Li
Wenxin
W
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D000483:Alleles; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D060588:LIM Domain Proteins; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012008:Recurrence
D048868:Adaptor Proteins, Signal Transducing; D060588:LIM Domain Proteins; C512485:PDLIM5 protein, human