title: Modulation of angiogenesis for cancer prevention: strategies based on antioxidants and copper deficiency.
abstract: Although anti- angiogenesis strategies have generated much enthusiasm for therapeutic applications, it is still unknown whether they would be feasible for prevention. The possibility of interfering very early in tumor progression by modulating the cancer angiogenic switch is appealing. In this chapter, we review progress with in vitro and in vivo models that show that anti-angiogenic interventions may be amenable to long- term chemopreventive measures. In particular, some approaches that are nearly ready for major applications are anti-oxidant nutraceuticals and copper deficiency. We use these strategies as paradigms of how to make progress in this difficult but important area of translational research.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
authors.forename: Gazala N
authors.initials: GN
authors.lastname: Khan
authors.forename: Sofia D
authors.initials: SD
authors.lastname: Merajver
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control; D002338:Carotenoids / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003300:Copper / Q000172:deficiency / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D008982:Molybdenum / Q000494:pharmacology; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000517:prevention & control*; D010636:Phenols / Q000494:pharmacology; D059808:Polyphenols; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000517:prevention & control; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002614:Chelating Agents; D005419:Flavonoids; D016328:NF-kappa B; D010636:Phenols; D059808:Polyphenols; D017382:Reactive Oxygen Species; D002338:Carotenoids; D003300:Copper; D008982:Molybdenum; C020809:tetrathiomolybdate