Effect of charge and size of diffusing probe on the diffusion through calcium alginate gel matrices.
The diffusion of latex particles and low molecular weight fluorescein analogues in homogenous, well-defined calcium alginate gel matrices was studied. The experimental results indicate that the different types of diffusion probes are retarded by different mechanisms in the gel. The positively charged low molecular weight substance experienced some degree of retardation by the gels, but the diffusion rate of the uncharged low molecular weight substance was little influenced by gel composition. A wide range of diffusion rates was observed for the particles in the various gel compositions.
Holte
Ø
Ø
School of Pharmacy, University of Oslo, Norway. oholte@farmasi.uio.no
Tønnesen
H H
HH
Karlsen
J
J
D000464:Alginates / Q000737:chemistry*; D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004396:Coloring Agents; D003627:Data Interpretation, Statistical; D004058:Diffusion; D019793:Fluorescein; D005782:Gels / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007840:Latex; D008970:Molecular Weight
D000464:Alginates; D004396:Coloring Agents; D005782:Gels; D006603:Hexuronic Acids; D007840:Latex; D020723:Glucuronic Acid; D019793:Fluorescein