title: MPA: a multiple peak alignment algorithm to perform multiple comparisons of liquid-phase proteomic profiles.
abstract: Present proteomic studies increasingly address experimental strategies focused on multiple comparisons of proteomic profiles. To accomplish semiautomatic protein separations based on 2-D LC, the Beckman Coulter PF2D has been developed. Here, we present a novel general purpose tool called MPA (multiple peak alignment) able to perform multiple comparisons of proteomic profiles both in a pairwise guided fashion and in a fully automatic mode using a strategy based on dynamic programing and progressive alignment of time series. The tool is available at http://grup.cribi.unipd.it/people/stefano/mpa/.
authors.affiliation: Department of Biological Chemistry, University of Padua, via G. Colombo, Padua, Italy. stefano.toppo@unipd.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Toppo
authors.forename: Antonella
authors.initials: A
authors.lastname: Roveri
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Vitale
authors.forename: Mattia
authors.initials: M
authors.lastname: Zaccarin
authors.forename: Elena
authors.initials: E
authors.lastname: Serain
authors.forename: Emanuele
authors.initials: E
authors.lastname: Apostolidis
authors.forename: Massimo
authors.initials: M
authors.lastname: Gion
authors.forename: Matilde
authors.initials: M
authors.lastname: Maiorino
authors.forename: Fulvio
authors.initials: F
authors.lastname: Ursini
mesh_terms: D000465:Algorithms; D002853:Chromatography, Liquid / Q000379:methods*; D019295:Computational Biology; D040901:Proteomics / Q000379:methods*; D012984:Software