[Mortality and morbidity in patients with alcohol and biliary-induced acute pancreatitis].
BACKGROUND
Acute Pancreatitis (AP) is a serious disease with a high mortality. The main aetiological factors involved in development of AP are alcohol and gallstones. Whether aetiology influences mortality and morbidity in AP is not clarified.


METHODS
The aim of the present study was to determine if there was a significant difference in mortality in alcohol or biliary-induced AP. We retrospectively analysed data comprising all patients admitted to our department with a first attack of AP registered in a 5-year period (2000-2004).


RESULTS
A total of 290 patients were included. The 30-day and 1-year mortality risks were 5% and 11% and independent of aetiology. ASA-score and severity of AP had a significant effect on the 30-day mortality risk (OR = 9.2 for ASA-score > 2 and OR = 4.2 for severe AP), while daily use of prescribed medicine and ASA-score had a significant effect on the 1-year mortality risk (OR = 10.4 for medicine and OR = 4.5 for ASA-score > 2). Severe AP was a significant predictor for treatment at the Intensive Care Unit (OR = 26.2), as was daily use of prescribed medicine (OR = 7.3).


CONCLUSIONS
Our data shows that AP is associated with considerable mortality and that there is no significant difference in mortality in relation to alcohol or biliary aetiology.
Andersen
Anders Møller
AM
Bispebjerg Hospital, Kirurgisk Gastroenterologisk Afdeling K, Købehavn NV.
Novovic
Srdan
S
Ersbøll
Annette Kjaer
AK
Hansen
Mark Berner
MB
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D042882:Gallstones / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000209:etiology / Q000401:mortality*; D019512:Pancreatitis, Alcoholic / Q000150:complications / Q000209:etiology / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed