[Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients].
Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.
Aicher
W K
WK
Zentrum für Medizinische Forschung, Orthopädische Universitätsklinik, Eberhard-Karls-Universität Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Deutschland. Aicher@uni-tuebingen.de
Pap
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Gay
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D001172:Arthritis, Rheumatoid / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007797:Laminin / Q000276:immunology*; D018448:Models, Immunological; D013583:Synovial Membrane / Q000276:immunology* / Q000473:pathology
D016207:Cytokines; D007797:Laminin