Clinical and histopathological features and a unique spectrum of organisms significantly associated with chronic granulomatous disease osteomyelitis during childhood.
Herein, we describe a combination of clinical, microbiologic, and histopathologic findings significantly associated with osteomyelitis in chronic granulomatous disease. When present, these features should raise the suspicion of underlying chronic granulomatous disease. In patients with these findings, anti-infective prophylactic measures aiming to cover highly prevalent microorganisms, as well as aggressive therapeutic measures, should be strongly encouraged.
Galluzzo
M L
ML
Servicio de Patología, Hospital Nacional de Pediatría J. P. Garrahan, Buenos Aires, Argentina.
Hernandez
C
C
Davila
M T G
MT
Pérez
L
L
Oleastro
M
M
Zelazko
M
M
Rosenzweig
S D
SD
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D001230:Aspergillus / Q000302:isolation & purification; D001842:Bone and Bones / Q000473:pathology; D016022:Case-Control Studies; D018890:Chemoprevention; D002648:Child; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D010407:Penicillium / Q000302:isolation & purification; D016868:Serratia Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D012706:Serratia marcescens / Q000302:isolation & purification
D000900:Anti-Bacterial Agents