Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin.
Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-alpha high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.
Corsi
Massimiliano M
MM
Institute of General Pathology, Laboratory of Clinical Pathology, University of Milan, Via L. Mangiagalli 31, I-20133 Milan, Italy. mmcorsi@unimi.it
Dogliotti
Giada
G
Pedroni
Francesca
F
Galliera
Emanuela
E
Malavazos
Alexis E
AE
Villa
Roberto
R
Chiappelli
Martina
M
Licastro
Federico
F
D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D015850:Interleukin-6 / Q000097:blood; D007558:Italy / Q000453:epidemiology; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D008955:Models, Cardiovascular; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha