Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptides.
This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration. More specifically, C-terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer's, Parkinson's and motor neuron disease.
Greenfield
Susan A
SA
The Institute for the Future of the Mind, Oxford University, UK.
Zimmermann
Martina
M
Bond
Cherie E
CE
D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism*; D000544:Alzheimer Disease / Q000201:enzymology / Q000473:pathology; D000818:Animals; D006801:Humans; D008954:Models, Biological; D016472:Motor Neuron Disease / Q000201:enzymology / Q000473:pathology; D009410:Nerve Degeneration / Q000201:enzymology / Q000473:pathology; D010300:Parkinson Disease / Q000201:enzymology / Q000473:pathology; D010455:Peptides / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D010455:Peptides; D000110:Acetylcholinesterase