Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin, HMGNCIDIN, composed of HMGN2 a-helical domain and PE38 KDEL domain III.
Xiong
Wen-bi
WB
Department of Pharmacology, West China Medical Center, Sichuan University, Chengdu, Sichuan 610041, China.
Huang
Ning
N
Feng
Yun
Y
Wu
Qi
Q
Wang
Bo-yao
BY
D036002:ADP Ribose Transferases / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000737:chemistry / Q000494:pharmacology*; D005098:Exotoxins / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D024242:HMGN2 Protein / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000494:pharmacology*; D037521:Virulence Factors / Q000737:chemistry / Q000494:pharmacology*; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D000970:Antineoplastic Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D024242:HMGN2 Protein; D000922:Immunotoxins; D011993:Recombinant Fusion Proteins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A