Preliminary study on the development of nanoemulsions for carbamazepine intravenous delivery: an investigation of drug polymorphic transition.
Carbamazepine (CBZ) is available on the pharmaceutical market as tablets, capsules, and oral suspensions, but not as a parenteral formulation for clinical use. Parenteral emulsions are a good alternative to poorly water-soluble drugs such as CBZ. In this way, four different emulsions containing 3 mg/mL of CBZ were developed, but during a period of storage, drug crystal precipitates appeared. To investigate this phenomenon, differential scanning calorimetry, infrared spectroscopy, and light microscopy were employed. The results suggested a polymorphic transition from beta form to dehydrate form, resulting in drug precipitation, although the emulsions themselves remained stable for at least three months.
Kelmann
Regina G
RG
Departamento de Ciências Farmacêuticas, Laboratório de Controle de Qualidade, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Florianópolis, SC, Brazil.
Kuminek
Gislaine
G
Teixeira
Helder F
HF
Koester
Letícia S
LS
D000927:Anticonvulsants / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002220:Carbamazepine / Q000008:administration & dosage / Q000737:chemistry*; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013055:Spectrophotometry, Infrared
D000927:Anticonvulsants; D045703:Emulsifying Agents; D004655:Emulsions; D002220:Carbamazepine