title: Somatostatin and propranolol to treat small-for-size syndrome that occurred despite splenic artery ligation.
abstract: We report our success with somatostatin and propranolol to treat small-for-size syndrome that occurred despite splenic artery ligation. A 48-year-old woman with cirrhosis due to autoimmune hepatitis underwent living-donor liver transplant; her graft-to-body weight ratio of the right lobe was 0.91%. After arterial reperfusion, portal pressure and flow were 24 cm H20 and 2.22 L/min (ie, 360 mL/100g graft/min), respectively. Following splenic artery ligation, the portal pressure decreased to 16 cm H20 and portal flow to 1.74 L/min (ie, 282 mL/100g graft/min). On the second postoperative day, small-for-size syndrome was diagnosed based on the marked prolongation of prothrombin time (international normalized ratio, 4.4), hyperbilirubinemia (359.1 micromol/L), rapid escalation of transaminases (alanine aminotransferase 2488 U/L, aspartate aminotransferase 1075 U/L) and very high portal flow rate (> 90 cm/sec). Oral propranolol (40 mg/day b.i.d.) and somatostatin infusion (250-microgram bolus followed by perfusion at a rate of 250 microgram/h for 5 days) were started. Prothrombin time and transaminase levels began to decrease the following day, although the bilirubin level increased to 495.9 micromol/L before returning to normal. The patient was discharged in excellent health 5 weeks after surgery. Despite reduction of portal pressure by splenic artery ligation, small-for-size syndrome may develop in patients with persistent high portal flow. To the best of our knowledge, this is the first report of the successful treatment of small-for-size syndrome by somatostatin and propranolol in the clinical setting.
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. iozden@hotmail.com
authors.forename: Ilgin
authors.initials: I
authors.lastname: Ozden
authors.forename: Melih
authors.initials: M
authors.lastname: Kara
authors.forename: Binnur
authors.initials: B
authors.lastname: Pinarbasi
authors.forename: Artur
authors.initials: A
authors.lastname: Salmaslioglu
authors.forename: Aysen
authors.initials: A
authors.lastname: Yavru
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Kaymakoglu
authors.forename: Ali
authors.initials: A
authors.lastname: Emre
authors.forename: Orhan
authors.initials: O
authors.lastname: Bilge
authors.forename: Aydin
authors.initials: A
authors.lastname: Alper
mesh_terms: D005260:Female; D006801:Humans; D008026:Ligation / Q000379:methods; D008099:Liver / Q000033:anatomy & histology* / Q000502:physiology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D009929:Organ Size; D011433:Propranolol / Q000627:therapeutic use*; D013004:Somatostatin / Q000627:therapeutic use*; D013157:Splenic Artery / Q000601:surgery
chemical_list: D013004:Somatostatin; D011433:Propranolol