In vitro activities of 35 double combinations of antifungal agents against Scedosporium apiospermum and Scedosporium prolificans.
Activities of 35 combinations of antifungal agents against Scedosporium spp. were analyzed by a checkerboard microdilution design and the summation of fractional concentration index. An average indifferent effect was detected apart from combinations of azole agents and echinocandins against Scedosporium apiospermum. Antagonism was absent for all antifungal combinations against both species.
Cuenca-Estrella
Manuel
M
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda Madrid, Spain. mcuenca-estrella@isciii.es
Alastruey-Izquierdo
Ana
A
Alcazar-Fuoli
Laura
L
Bernal-Martinez
Leticia
L
Gomez-Lopez
Alicia
A
Buitrago
Maria J
MJ
Mellado
Emilia
E
Rodriguez-Tudela
Juan L
JL
D000935:Antifungal Agents / Q000378:metabolism* / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008271:Mycetoma / Q000382:microbiology; D021681:Scedosporium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
D000935:Antifungal Agents