title: [Facial allograft transplantation: fiction or reality? Surgical techniques in a fresh human cadaver model].
abstract: BACKGROUND
  The aim of this study was to describe two methods of face-harvesting techniques -- a skin and soft tissue flap and a combined osteocutaneous flap -- and to demonstrate the compatibility between donor and recipient in a human fresh cadaver model.
  
  
  METHODS
  In fresh human cadavers the skin and soft tissue of the face (type 1) and a combined osteocutaneous flap (including a le Fort III segment, type 2) were harvested. The faces were subsequently exchanged among the donor crania, simulating full-face transplantation.
  
  
  RESULTS
  Both flaps are based on the external blood supply of the faciotemporal vessels and the external jugular vein. The end branches of the trigeminal nerve could potentially be used for restoration of sensation (type 1 flap). With type 2 flaps the facial expression may be restored with the inclusion of the facial nerve. Four morphological parameters determine the donor/recipient compatibility: skin color and texture, anthropometric head dimensions, specific soft tissue components (nose, lip, cheek, and eyebrow), and gender.
  
  
  CONCLUSIONS
  Apart from ethical considerations, long-term immunosuppression will remain the limiting factor of full facial transplantation in the near future.
authors.affiliation: Division of Plastic, Reconstructive, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: C
authors.initials: C
authors.lastname: Messmer
authors.forename: A
authors.initials: A
authors.lastname: Baccarani
authors.forename: K E
authors.initials: KE
authors.lastname: Follmar
authors.forename: S
authors.initials: S
authors.lastname: Mukundan
authors.forename: L S
authors.initials: LS
authors.lastname: Levin
authors.forename: J R
authors.initials: JR
authors.lastname: Marcus
authors.forename: D
authors.initials: D
authors.lastname: Erdmann
mesh_terms: D005145:Face / Q000002:abnormalities* / Q000098:blood supply / Q000294:innervation; D005151:Facial Injuries / Q000601:surgery*; D005153:Facial Neoplasms / Q000601:surgery*; D054445:Facial Transplantation / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008134:Long-Term Care; D008866:Microsurgery / Q000379:methods; D013524:Surgical Flaps / Q000098:blood supply / Q000294:innervation; D020858:Tissue and Organ Harvesting / Q000379:methods; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents