Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation.
Fusarium infections are associated with high mortality after allogeneic stem cell transplantation. We report on successful treatment of a disseminated cutaneous Fusarium proliferatum infection using liposomal amphotericin B and terbinafine. In vitro susceptibility tests of antifungal drugs suggest that terbinafine is a potent additional antifungal drug for disseminated cutaneous fusariosis.
Neuburger
S
S
Department of Hematology and Oncology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany. stefan.neuburger@charite.de
Massenkeil
G
G
Seibold
M
M
Lutz
C
C
Tamm
I
I
le Coutre
P
P
Graf
B
B
Doerken
B
B
Arnold
R
R
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D005260:Female; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D009503:Neutropenia / Q000150:complications; D016879:Salvage Therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D000077291:Terbinafine; D014184:Transplantation, Homologous / Q000009:adverse effects*; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077291:Terbinafine