title: Glycemic control in adolescents with type 1 diabetes mellitus improves lipid serum levels and oxidative stress.
abstract: BACKGROUND
  Atherosclerosis begins in childhood, and diabetes is a risk factor for coronary heart disease. Dyslipidemia is prevalent in children with type 1 diabetes mellitus (T1DM), with an association between elevated hemoglobin A1c (HbA1c), serum lipid levels, and oxidative stress. Our aim was to examine the effect of metabolic control on serum lipid levels and oxidative stress in adolescents with T1DM.
  
  
  METHODS
  Twenty-six adolescents (13 boys and 13 girls), aged 15.65 +/- 1.5 yr, with disease duration of 5.9 +/- 2.8 yr and average HbA1c 10.8 +/- 1.9% were assigned to intensive insulin therapy for 3 months. Comparisons for HbA1c, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, total triglycerides (TG), total cholesterol (TC), apolipoprotein AI, apolipoprotein AII, apolipoprotein B (ApoB), and thiobarbituric acid reactive substances (TBARS) were done between patients whose HbA1c improved by 0.5% or more (GR1) and the rest of the cohort (patients whose HbA1c improved by <0.5%, did not change, or increased) (GR2).
  
  
  RESULTS
  ApoB (p = 0.047) and TBARS (p = 0.01) were significantly lower at the end of the study in GR1. In GR2, TC (p = 0.01) and LDL (p = 0.03) were significantly higher at study end. Overall, significant beneficial changes in TC (p = 0.006), TG (p = 0.04), LDL (p = 0.02), ApoB (p = 0.015), and oxidative stress (p = 0.001) were found in GR1 compared with GR2.
  
  
  CONCLUSIONS
  We provide direct evidence for the beneficial effect of tight metabolic control on serum lipids and oxidative stress in adolescents with T1DM, indicating that tight metabolic control may reduce cardiovascular risk in these patients.
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, Meyer Children's Hospital of Haifa, Rambam medical Center, Technion-Israel Institute of Technology, Haifa, Israel. shamirr@netvision.net.il
authors.forename: Raanan
authors.initials: R
authors.lastname: Shamir
authors.forename: Haifa
authors.initials: H
authors.lastname: Kassis
authors.forename: Marielle
authors.initials: M
authors.lastname: Kaplan
authors.forename: Tova
authors.initials: T
authors.lastname: Naveh
authors.forename: Naim
authors.initials: N
authors.lastname: Shehadeh
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007557:Israel; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances