title: Vasorelaxing alkaloids and flavonoids from Cassytha filiformis.
abstract: Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid ( 3), cassythine ( 4), neolitsine ( 7), and dicentrine ( 8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyaporphine ( 2), (-)- O-methylflavinatine ( 10), (-)-salutaridine ( 11), isohamnetin-3- O-beta-glucoside, and isohamnetin-3- O-rutinoside exerted moderate vessel-relaxing activities with IC 50 values from 16.50 to 32.81 microM at the test concentrations.
authors.affiliation: Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
authors.forename: Tung-Hu
authors.initials: TH
authors.lastname: Tsai
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013624:Taiwan; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C528206:1,2-methylenedioxy-3,10,11-trimethoxyaporphine; D000470:Alkaloids; D001060:Aporphines; D005419:Flavonoids; D014665:Vasodilator Agents; C528205:isofiliformine