title: Amoxapine-associated acute respiratory distress.
abstract: A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground-glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions. BAL showed a predominance of neutrophils, lymphocytes and erythrocytes but not eosinophils. Amoxapine was stopped, resulting in complete resolution of the pulmonary infiltrates. When the patient was re-exposed to amoxapine (52.5 mg total dose), high fever, reduced SaO(2) and pulmonary infiltrates reappeared. We concluded that acute respiratory distress may be associated with amoxapine treatment.
authors.affiliation: Division of Pulmonary Disease, Department of Brain and Nerve Science, Oita University Faculty of Medicine, Oita, Japan. mando@med.oita-u.ac.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Ando
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Ryu-Ichi
authors.initials: R
authors.lastname: Takenaka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okubo
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsuno
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nureki
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ito
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Tsuda
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kumamoto
mesh_terms: D000328:Adult; D000657:Amoxapine / Q000009:adverse effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000657:Amoxapine