title: Tandem RCM-isomerization-cyclopropanation reactions.
abstract: A new triple tandem process has been discovered in which simple acyclic substrates can be transformed into bicyclic compounds via RCM-double bond isomerization-cyclopropanation. This process is catalyzed by second generation Grubb's catalyst without the requirement of other reactives or additives. In addition, a one-pot RCM-isomerization reaction followed by cyclopropanation with CHCl3/NaOH allows the synthesis of products related to iNOS (nitric oxide synthase) inhibitors, which are currently under clinical evaluation.
authors.affiliation: Facultad de Farmacia, Dpto. Química, Universidad San Pablo CEU, Urb. Montepríncipe, ctra. Boadilla km 5,300 Boadilla del Monte, 28668 Madrid, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mallagaray
authors.forename: Gema
authors.initials: G
authors.lastname: Domínguez
authors.forename: Ana
authors.initials: A
authors.lastname: Gradillas
authors.forename: Javier
authors.initials: J
authors.lastname: Pérez-Castells
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D003521:Cyclopropanes; D019001:Nitric Oxide Synthase