AAA+ proteins: diversity in function, similarity in structure.
The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nucleotide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. In addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.
Snider
Jamie
J
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.
Houry
Walid A
WA
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000201:enzymology
D008666:Metalloendopeptidases; C114583:m-AAA proteases