Fatal cytomegalovirus gastrointestinal disease in an infant with Wiskott-Aldrich syndrome.
Although most cytomegalovirus (CMV) infections are asymptomatic or cause only mild disease, the virus can cause serious disease and even mortality in immunocompromised children. In patients with Wiskott-Aldrich syndrome (WAS), recurrent CMV infection is infrequently seen. A 3-month-old male infant was referred to Chang Gung Children's Hospital due to persistent thrombocytopenia and intermittent tachypnea. WAS complicated with CMV pneumonitis was diagnosed subsequently. He was discharged at the age of 7 months after a complete course of antiviral treatment. Unfortunately, refractory hemorrhagic gastritis developed later and recurred in spite of antiviral treatment and intravenous immunoglobulin. The patient died of recurrent gastrointestinal bleeding at the age of 23 months. This observation indicates that a case of WAS complicated with CMV gastrointestinal disease may need more vigorous treatment.
Huang
Kuan-Ying
KY
Division of Infectious Diseases, Department of Pediatrics, Chang Gung Childrens Hospital, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Lai
Ming-Wei
MW
Lee
Wen-I
WI
Huang
Yhu-Chering
YC
D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D017809:Fatal Outcome; D005767:Gastrointestinal Diseases / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis*; D014923:Wiskott-Aldrich Syndrome / Q000150:complications*