title: Signet ring-like cells in pituitary adenoma.
abstract: We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems. The patient had received clomiphen citrate and human chorionic gonadotrophin for 3 years. Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells. The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin. The clinicopathologic features and diagnostic difficulties of this rare entity are discussed.
authors.affiliation: Department of Pathology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. kdeniz@erciyes.edu.tr
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanriverdi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Selçuklu
authors.forename: Olgun
authors.initials: O
authors.lastname: Kontaş
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Keleştimur
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002864:Chromogranins / Q000378:metabolism; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007247:Infertility, Female / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016708:Synaptophysin / Q000378:metabolism; D014786:Vision Disorders / Q000209:etiology
chemical_list: D006063:Chorionic Gonadotropin; D002864:Chromogranins; D005300:Fertility Agents, Female; D016708:Synaptophysin; D002996:Clomiphene