Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.
The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.
Tashjian
Jessica A
JA
Department of Radiation Oncology, Duke University, Durham, NC 27710, USA.
Dewhirst
Mark W
MW
Needham
David
D
Viglianti
Benjamin L
BL
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008081:Liposomes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D051381:Rats; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D000970:Antineoplastic Agents; D008081:Liposomes