title: Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis.
abstract: OBJECTIVE
  To investigate the diagnostic and differential diagnostic values of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prostatic diseases, and to investigate the correlation between the parameters of SI-T curves and angiogenesis.
  
  
  METHODS
  Twenty-one patients with proven prostatic carcinoma (Pca) and 29 patients with proven benign prostatic hyperplasia (BPH) were examined using DCE MRI. Diagnostic characteristics for differentiation were examined using threshold values for maximum peak time, enhancement degree, and enhancement rate. Then, the signal intensity-time curves (SI-T curves) were analysed, and the correlations between the parameters of SI-T curves and the expression levels of vascular endothelial growth factor (VEGF) and microvascular density (MVD) were investigated. All patents underwent prostatectomy. DCE MRI and histological findings were correlated.
  
  
  RESULTS
  Pca showed stronger enhancement with an earlier peak time, higher enhancement, and enhancement rate (p<0.05). Regarding the type of SI-T curves, in the BPH group six were type A, 10 were type B, and 13 were type C, whereas in the Pca group, 14 were type A, six were type B, and only one was type C (Chi-square test, chi2=13.57, P<0.005). The VEGF and MVD expression levels of Pca were higher than those of BPH. Peak time was negatively correlated with the expression levels of VEGF and MVD, whereas the enhancement degree and enhancement rate showed positive correlations (Pearson correlation, p<0.05).
  
  
  CONCLUSIONS
  Based on T2-weighted imaging, DCE MRI curves can help to differentiate benign from malignant prostate tissue. In the present study the type C curve was rarely seen with malignant disease, but these results need confirmation.
authors.affiliation: Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: Y
authors.initials: Y
authors.lastname: Huan
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Chang
authors.forename: H-T
authors.initials: HT
authors.lastname: Zhao
authors.forename: Y-L
authors.initials: YL
authors.lastname: Ge
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000098:blood supply / Q000175:diagnosis; D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011467:Prostate / Q000098:blood supply*; D011470:Prostatic Hyperplasia / Q000175:diagnosis*; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000175:diagnosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A