Anthocleistenolide, a new rearranged nor-secoiridoid derivative from the stem back of Anthocleista vogelii.
A new rearranged nor-secoiridoid, anthocleistenolide ( 1), along with the known 1-hydroxy-3,7-dimethoxyxanthone ( 2), 1-hydroxy-3,7,8-trimethoxyxanthone ( 3), 7 alpha-hydroxysitosterol ( 4) and sitosterol 3- O-beta- D-glucopyranoside ( 5), were isolated from the stem back of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC = 200 microg/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 microg/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 microg/mL for 2 and 25 microg/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.
Tene
Mathieu
M
Chemistry Department, University of Dschang, Dschang, Cameroon. mtene2001@yahoo.fr
Tane
Pierre
P
Kuiate
Jules-Roger
JR
Tamokou
Jean de Dieu
Jde D
Connolly
Joseph D
JD
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D029965:Gentianaceae; D006801:Humans; D039823:Iridoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D039823:Iridoids; D010936:Plant Extracts; C527968:anthocleistenolide