title: Intracoronary nicorandil relieves multiple coronary vasospasm with hemodynamic collapse.
abstract: A 49-year-old woman was referred to hospital because of chest discomfort. Coronary angiography revealed subtotal occlusion of the left coronary artery and the right coronary artery, but subsequent hemodynamic collapse occurred. Based on the results of intravascular ultrasound the occlusion was suspected to be caused by coronary vasospasm, which was not relieved by intracoronary injection of isosorbide dinitrate (1 mg), but was alleviated by nicorandil (2 mg), a potassium-channel opener. After discharge from hospital, the patient stopped taking her medication and returned complaining of chest discomfort again. Intravenous verapamil (5 mg) did not improve it, but direct intracoronary administration of nicorandil (2 mg) did bring relief. This case suggests that nicorandil is effective for coronary vasospasm.
authors.affiliation: Cardiovascular Division,Kawachi General Hospital, 1-31 Yokomakura, Higashi-osaka 578-0955, Japan. takaharu@kawati.org
authors.forename: Takaharu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Minoru
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Akio
authors.initials: A
authors.lastname: Iwata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakata
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Lim
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mishima
mesh_terms: D003329:Coronary Vasospasm / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D008875:Middle Aged; D020108:Nicorandil / Q000008:administration & dosage*; D012769:Shock / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil; D014700:Verapamil; D007548:Isosorbide Dinitrate