Preparation and biomedical application of a non-polymer coated superparamagnetic nanoparticle.
We report the preparation of a non-polymer coated superparamagnetic nanoparticle that is stable and biocompatible both in vitro and in vivo. The non-polymer, betaine, is a natural methylating agent in mammalian liver with active surface property. Upon systemic administration, the nanoparticle has preferential biodistribution in mammalian liver and exhibits good reduction of relaxivity time and negative enhancement for the detection of hepatoma nodules in rats using MRI. Our data demonstrate that the non-polymer coated superparamagnetic nanoparticle should have potential applications in biomedicine.
Du
Lin
L
Institute of Molecular and Chemical Biology, East China Normal University, Shanghai, China.
Chen
Jianzhao
J
Qi
Yanting
Y
Li
Dan
D
Yuan
Chonggang
C
Lin
Marie C
MC
Yew
David T
DT
Kung
Hsiang-Fu
HF
Yu
Jimmy C
JC
Lai
Lihui
L
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D003287:Contrast Media / Q000737:chemistry*; D003911:Dextrans; D052203:Ferrosoferric Oxide; D007089:Image Enhancement / Q000379:methods; D007501:Iron / Q000737:chemistry*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D051381:Rats
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide