Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents.
In the present study, a novel series of 4-pyrrol-1-yl benzoic acid hydrazide analogs, some derived 5-substituted-2-thiol-1,3,4-oxadiazoles, 5-substituted-4-amino-1,2,4-triazolin-3-thione and 2,5-dimethyl pyrroles have been synthesized in good yields and characterized by IR, NMR, mass spectral and elemental analyses. Compounds were evaluated for their preliminary in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria and compounds were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth dilution assay method. Some compounds showed very good antibacterial and antitubercular activities.
Joshi
S D
SD
Department of Pharmaceutical Chemistry, S.E.T's College of Pharmacy, S.R. Nagar, Dharwad, Karnataka, India.
Vagdevi
H M
HM
Vaidya
V P
VP
Gadaginamath
G S
GS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019817:Benzoic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010069:Oxadiazoles / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D010069:Oxadiazoles; D011758:Pyrroles; D014230:Triazoles; D019817:Benzoic Acid