title: Measurable serum markers of oxidative stress response in women with endometriosis.
abstract: OBJECTIVE
  To evaluate the hypothesis of increased systemic oxidative stress in patients with endometriosis.
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Sixty-six women of reproductive age undergoing laparoscopy.
  
  
  METHODS
  All women were investigated for endometriotic foci during laparoscopy. Forty-five women had laparoscopically and histologically confirmed endometriosis, and 21 women did not have endometriosis.
  
  
  METHODS
  Four markers of oxidative stress were assessed in the serum of each patient: heat shock protein 70 (HSP70), HSP70b', thioredoxin (TRX), and ischemia-modified albumin (IMA).
  
  
  RESULTS
  Mean serum HSP 70b' level was higher in patients with endometriosis compared with controls (0.178 ng/mL, SD 0.103, and 0.135 ng/mL, SD 0.014, respectively). The disease stage did not affect HSP70b' levels. Heat shock protein 70, IMA, and TRX levels did not differ between patients with endometriosis and controls. Women with a history of arterial hypertension had higher mean IMA levels compared with women with normal blood pressure independently of the presence of endometriosis (106.7 [SD 25.4] U/mL and 85.0 [SD 11.5] U/mL, respectively).
  
  
  CONCLUSIONS
  Endometriosis is associated with increased systemic oxidative stress. The implication of increased systemic oxidative stress in disease progression or the association with other oxidative stress-related pathologic conditions needs to be addressed in further studies.
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece. ilambrinoudaki@hotmail.com
authors.forename: Irene V
authors.initials: IV
authors.lastname: Lambrinoudaki
authors.forename: Areti
authors.initials: A
authors.lastname: Augoulea
authors.forename: George E
authors.initials: GE
authors.lastname: Christodoulakos
authors.forename: Emmanuel V
authors.initials: EV
authors.lastname: Economou
authors.forename: George
authors.initials: G
authors.lastname: Kaparos
authors.forename: Antonios
authors.initials: A
authors.lastname: Kontoravdis
authors.forename: Constantinos
authors.initials: C
authors.lastname: Papadias
authors.forename: George
authors.initials: G
authors.lastname: Creatsas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D010535:Laparoscopy; D008597:Menstrual Cycle / Q000502:physiology; D018384:Oxidative Stress; D010298:Parity; D011247:Pregnancy; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism*; D013879:Thioredoxins / Q000097:blood*
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; C491129:HSPA7 protein, human; D012709:Serum Albumin; D013879:Thioredoxins