title: Health-related quality of life in adults with cystic fibrosis: the role of coping.
abstract: OBJECTIVE
  This study examined the role of coping in explaining health-related quality of life (HRQoL) in cystic fibrosis (CF).
  
  
  METHODS
  Coping, quality of life, and clinical variables were assessed. The CF Coping Scale measures four ways of coping: optimistic acceptance, hopefulness, distraction, and avoidance. The Cystic Fibrosis Quality of Life Questionnaire (CFQoL) comprises 9 domains: physical, social, treatment, chest symptoms, emotional, body image, relationships, career, and future. Step-wise multiple regression and path analysis were used to model the associations between coping and CFQoL domains, taking into account important demographic and clinical factors.
  
  
  RESULTS
  One hundred and sixteen people with CF were recruited to the study. Their mean FEV(1)% predicted and BMI were 59.3% and 21.2 kg/m(2), respectively. Mean scores were highest for optimism and lowest for distraction coping. Coping had an inequitable influence across the CFQoL domains: it had negligible influence on domains that incorporate symptoms and aspects of physical functioning but considerable influence on psychosocial domains. Optimism and distraction were strongly associated with emotional responses, social functioning, and interpersonal relationships. A high level of optimism was associated with a better HRQoL and high levels of distraction with a poorer HRQoL. For some domains, optimism and distraction had a counterbalancing effect so the difference between them could be an important predictor of HRQoL.
  
  
  CONCLUSIONS
  Coping has emerged as an important factor in explaining some quality-of-life domains but not others. This has important implications especially when employing HRQoL as an outcome measure in clinical trials.
authors.affiliation: Faculty of Health, University of Central Lancashire, Preston, United Kingdom. jabbott@uclan.ac.uk
authors.forename: Janice
authors.initials: J
authors.lastname: Abbott
authors.forename: Anna
authors.initials: A
authors.lastname: Hart
authors.forename: Alison
authors.initials: A
authors.lastname: Morton
authors.forename: Louise
authors.initials: L
authors.lastname: Gee
authors.forename: Steven
authors.initials: S
authors.lastname: Conway
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires