Genetic aspects in attention-deficit/hyperactivity disorder.
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder among children and adolescents with high heritability. Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large-scale genome wide association studies, gene-environement interaction studies, and pharmacogenetics. This article comprehensively reviews the latest findings on the genetics of ADHD.
Albayrak
O
O
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany. oezguer.albayrak@uni-due.de
Friedel
S
S
Schimmelmann
B G
BG
Hinney
A
A
Hebebrand
J
J
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D058851:GPI-Linked Proteins; D005823:Genetics; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000235:genetics; D012307:Risk Factors
D058851:GPI-Linked Proteins; D019006:Neural Cell Adhesion Molecules; C092530:neurotrimin