Genetic structure of hereditary catalepsy in mice.
Catalepsy or pronounced freezing is a natural passive defense strategy in animals and a syndrome of some mental disorders in human. Hereditary catalepsy was shown to be associated with depressive-like features in rats and mice. The loci underlying the difference in predisposition to catalepsy between catalepsy-prone CBA/lacJ and catalepsy-resistant AKR/J mice were mapped using congenic line and selective breeding approaches. Three congenic mouse lines (AKR.CBA-D13Mit76C, AKR.CBA-D13Mit76A and AKR.CBA-D13Mit78) carrying the 59- to 70-, 61- to 70- and 71- to 75-cm fragments of chromosome 13 transferred from the CBA to the AKR genome were created by nine successive backcrossing of (CBA x AKR)F(1) on AKR strain. Because catalepsy was found only in the AKR.CBA-D13Mit76C and AKR.CBA-D13Mit76A mice, the major gene of catalepsy was mapped on the fragment of 61-70 cm. Selective breeding of the (CBA x (CBA x AKR))BC backcross generation for high predisposition to catalepsy showed numerous genome-wide distributed CBA-derived alleles as well as the AKR-derived alleles mapped on chromosome 17 and on the proximal parts of chromosomes 10 and 19 that increased the cataleptogenic effect of the major gene.
Kulikov
A V
AV
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. akulikov@ngs.ru
Bazovkina
D V
DV
Kondaurova
E M
EM
Popova
N K
NK
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D002375:Catalepsy / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D008818:Mice, Neurologic Mutants; D013045:Species Specificity