Influenza virus hemagglutinin--structural studies and their implications for the development of therapeutic approaches.
Possible adaptation of one of the currently circulating strains of highly pathogenic H5N1 avian influenza A virus to produce the next human influenza pandemic is an area of major global concern. Intense research is being focused on developing new generations of effective vaccines and antivirals. Here, we discuss the structure of hemagglutinin and its potential as a target for development of future therapeutics to mitigate the impact of any future influenza pandemic.
Stevens
James
J
Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. fwb4@cdc.gov
Donis
Ruben O
RO
D000818:Animals; D001717:Birds / Q000821:virology; D003140:Communicable Disease Control; D004189:Disaster Planning; D004196:Disease Outbreaks / Q000517:prevention & control*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D007252:Influenza Vaccines / Q000627:therapeutic use; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines