[Gene regulation by steroid receptors].
Steroid hormone receptors are ligand-dependent transcriptional factors and regulate cell differentiation, proliferation, and homeostasis. Recently, many target genes of steroid hormone receptors were identified by genome-wide analysis and associated cofactors were also identified by proteomics analysis. From these findings, the molecular mechanism of ligand-dependent transactivation function of steroid hormone receptors have been elucidated. However, tissue specific regulation and extracellular signal-dependent regulation of steroid hormone receptor function are still under investigation.
Takada
Ichiro
I
Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo.
Kato
Shigeaki
S
D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011987:Receptors, Steroid / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D011987:Receptors, Steroid