Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.
BACKGROUND
We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004.


OBJECTIVE
To ensure that this consensus remains current.


METHODS
In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted.


RESULTS
This consensus algorithm outlines the approach recommended for the diagnosis, therapy, and management of HAE, which was agreed on by the authors of this report. This document is only a consensus algorithm approach and continues to require validation. As such, participants agreed to make this a living 2007 algorithm, a work in progress, and to review its content at future international HAE meetings.


CONCLUSIONS
There is a paucity of double-blind, placebo-controlled trials on the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Controlled trials currently under way will provide further insight into the management of HAE. As with our Canadian 2003 Consensus, this 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of HAE was formed through the meeting and agreement of patient care professionals along with patient group representatives and individual patients.
Bowen
Tom
T
Department of Medicine and Paediatrics, University of Calgary, Alberta, Canada. tbowen@pol.net
Cicardi
Marco
M
Bork
Konrad
K
Zuraw
Bruce
B
Frank
Mike
M
Ritchie
Bruce
B
Farkas
Henriette
H
Varga
Lilian
L
Zingale
Lorenza C
LC
Binkley
Karen
K
Wagner
Eric
E
Adomaitis
Peggy
P
Brosz
Kristylea
K
Burnham
Jeanne
J
Warrington
Richard
R
Kalicinsky
Chrystyna
C
Mace
Sean
S
McCusker
Christine
C
Schellenberg
Robert
R
Celeste
Lucia
L
Hebert
Jacques
J
Valentine
Karen
K
Poon
Man-Chiu
MC
Serushago
Bazir
B
Neurath
Doris
D
Yang
William
W
Lacuesta
Gina
G
Issekutz
Andrew
A
Hamed
Azza
A
Kamra
Palinder
P
Dean
John
J
Kanani
Amin
A
Stark
Donald
D
Rivard
Georges-Etienne
GE
Leith
Eric
E
Tsai
Ellie
E
Waserman
Susan
S
Keith
Paul K
PK
Page
David
D
Marchesin
Silvia
S
Longhurst
Hilary J
HJ
Kreuz
Wolfhart
W
Rusicke
Eva
E
Martinez-Saguer
Inmaculada
I
Aygören-Pürsün
Emel
E
Harmat
George
G
Füst
George
G
Li
Henry
H
Bouillet
Laurence
L
Caballero
Teresa
T
Moldovan
Dumitru
D
Späth
Peter J
PJ
Smith-Foltz
Sara
S
Nagy
Istvan
I
Nielsen
Erik W
EW
Bucher
Christoph
C
Nordenfelt
Patrik
P
Xiang
Zhi Yu
ZY
D000465:Algorithms; D054179:Angioedemas, Hereditary / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy*; D002170:Canada; D003245:Consensus Statements as Topic; D018849:Controlled Clinical Trials as Topic / Q000379:methods / Q000592:standards; D006801:Humans; D006814:Hungary; D007391:International Cooperation