title: Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata.
abstract: A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Annette
authors.initials: A
authors.lastname: Edser
authors.forename: Melissa
authors.initials: M
authors.lastname: Sykes
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.forename: Paul I
authors.initials: PI
authors.lastname: Forster
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Guymer
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives*; D043424:Carboxypeptidase B / Q000037:antagonists & inhibitors*; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028183:Loranthaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013386:Succinates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006146:Guanidines; D010936:Plant Extracts; D011480:Protease Inhibitors; D013386:Succinates; C528726:lysianadioic acid; D001120:Arginine; D043424:Carboxypeptidase B