Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis.
A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.
Frohman
Elliot M
EM
Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. elliot.frohman@utsouthwestern.edu
Costello
Fiona
F
Stüve
Olaf
O
Calabresi
Peter
P
Miller
David H
DH
Hickman
Simon J
SJ
Sergott
Robert
R
Conger
Amy
A
Salter
Amber
A
Krumwiede
Kimberly H
KH
Frohman
Teresa C
TC
Balcer
Laura
L
Zivadinov
Robert
R
D000818:Animals; D001369:Axons / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000473:pathology; D012025:Reflex, Pupillary / Q000502:physiology; D014795:Visual Pathways / Q000473:pathology* / Q000503:physiopathology