[Acid-base state of blood and accumulation of strontium in tissues of rats].
It is shown that the increase of strontium content 1.5, 1.7, 2.0, 1.7, and 5.1 times, respectively, in the liver, kidneys, heart, muscles and bones of poisoned rats leads to the state of subcompensated metabolic acidosis in them. Experimental deepening of metabolic acidosis with per os introducing of chloride acid parallel with intramuscular injection of strontium chloride reduces the accumulation of strontium in the muscles and kidneys 1.6, in the liver - 1.5, in bones - 2.7 times. Introduction of rats into metabolic acidosis state after their poisoning with strontium causes acceleration of mentioned metal elimination process from the muscles and kidneys 1.5 times, from the liver 1.3 times, from the bones 1.4 times, on the 20th day of research. The issues concerning subcompensated metabolic alkaloses observed in rats' blood, poisoned by strontium after per os introducing of sodium hydrocarbon. It is proved that this phenomenon does not influence accumulation of strontium both in the heart and bones, and it does not essentially reduce the accumulation of this element in the muscles, liver and kidneys. Therefore, the experimental results performed evidence that in the case of changing the acid-base state indices of blood in the direction of metabolic acidosis, one could reach the reduction of strontium accumulation in poisoned animals' organism, and acceleration of mentioned metal elimination process. It should be mentioned that metabolic alkaloses does not influence the intensity of the mentioned metal elimination process.
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D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000097:blood* / Q000378:metabolism; D000471:Alkalosis / Q000097:blood* / Q000378:metabolism; D000818:Animals; D008297:Male; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D013324:Strontium / Q000493:pharmacokinetics*
C025700:strontium chloride; D013324:Strontium