title: [The prognostic value of positive peritoneal lavage cytology and the prevention of peritoneal dissemination after colorectal surgery].
abstract: Peritoneal washing cytology during surgery was done in 745 patients with colorectal cancer. The positive washing cytology rate was 49/745 (6.6%). The peritoneal recurrence rates were 12/22 (54.5%) and 8/682 (1.3%) among patients with positive and negative peritoneal washing, respectively (p < 0.0001). The 5-year survival rate is 89.4% of the patients with positive cytology and 38.2% with negative cytology. The patients with positive cytology have a significantly lower survival rate than the negative one (p < 0.0001). Eleven patients of the positive cytology received intraperitoneal administration of MMC. Peritoneal dissemination occurred in 3/11 (27.3%) of the MMC treated group and 9/11 (81.8%) in the untreated group (p = 0.030). Our results indicated that intraperitoneal administration of MMC was an effective method of preventing peritoneal dissemination after resection of colorectal cancer.
authors.affiliation: Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tanida
authors.forename: Shingo
authors.initials: S
authors.lastname: Noura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohue
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Seki
authors.forename: Kunihito
authors.initials: K
authors.lastname: Gotoh
authors.forename: Masaaki
authors.initials: M
authors.lastname: Motoori
authors.forename: Kentarou
authors.initials: K
authors.lastname: Kishi
authors.forename: Kou
authors.initials: K
authors.lastname: Takachi
authors.forename: Terumasa
authors.initials: T
authors.lastname: Yamada
authors.forename: Isao
authors.initials: I
authors.lastname: Miyashiro
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohigashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yano
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
authors.forename: Shingi
authors.initials: S
authors.lastname: Imaoka
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
authors.forename: Masao
authors.initials: M
authors.lastname: Kameyama
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D003107:Colorectal Surgery; D006801:Humans; D009367:Neoplasm Staging; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary*; D011379:Prognosis; D015996:Survival Rate