The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5.
The efficiency of CCR5 as an HIV coreceptor is strongly dependent on its level of cell surface expression. Therefore, it is of major importance to identify the factors that regulate cell surface density of CCR5. Among the chemokines that bind to CCR5, and induce its internalization, CCL5 is the most abundant in vivo. We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.
Lin
Yea-Lih
YL
Institut de Génétique Humaine, CNRS UPR1142, France.
Mettling
Clément
C
Portalès
Pierre
P
Rouzier
Régine
R
Clot
Jacques
J
Reynes
Jacques
J
Corbeau
Pierre
P
D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*
C483024:CCL5 protein, human; D018946:Chemokine CCL5; D012333:RNA, Messenger; D019713:Receptors, CCR5