Fluorine in medicinal chemistry.
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Purser
Sophie
S
The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA.
Moore
Peter R
PR
Swallow
Steve
S
Gouverneur
Véronique
V
D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism
D006845:Hydrocarbons, Fluorinated