title: Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis.
abstract: Etanercept, a tumor necrosis factor (TNF) receptor alpha antagonist is licensed for the treatment in patients affected by polyarticular juvenile idiopathic arthritis, who do not tolerate or had an inadequate response to methotrexate. Infections related to immunosuppression by etanercept are of major concern. We report on a 17-year-old boy with enthesitis-related arthritis who developed a major infection of an urachal cyst 18 months after initiation of etanercept therapy, which required surgery. The urachus had not been symptomatic before.
authors.affiliation: Children's Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Wuerzburg, Germany. holl_a@kinderklinik.uni-wuerzburg.de
authors.forename: A
authors.initials: A
authors.lastname: Holl-Wieden
authors.forename: M
authors.initials: M
authors.lastname: Beer
authors.forename: A
authors.initials: A
authors.lastname: Marx
authors.forename: R
authors.initials: R
authors.lastname: Bonfig
authors.forename: D
authors.initials: D
authors.lastname: Tappe
authors.forename: H J
authors.initials: HJ
authors.lastname: Girschick
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy*; D001706:Biopsy; D002648:Child; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007239:Infections / Q000150:complications*; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D014463:Ultrasonography; D014496:Urachal Cyst / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept