title: Platinum, palladium and rhodium release from vehicle exhaust catalysts and road dust exposed to simulated lung fluids.
abstract: The risk associated with the inhalation of platinum group element (PGE) emissions from vehicle exhaust catalysts (VECs) has been investigated by extracting road dust and milled auto catalyst with simulated lung fluids. Gamble's solution (representative of the interstitial fluid of the deep lung) and artificial lysosomal fluid (ALF) (representative of the more acidic environment within the lung) were employed as extraction fluids. The highest PGE release was observed in ALF, implying that inhaled particles would have to be phagocytized before significant amounts of PGEs dissolve. The greatest percentage (up to 88%) of PGEs was released from road dust, possibly due to the presence of mobile PGE species formed in the roadside environment. Pt showed the highest absolute bioavailability, due to its greater concentration in the environmental samples. Pd and Rh had higher percentage of release, however, because of their more soluble nature. From the toxicological perspective, the results demonstrate potential health risks due to the likely formation of PGE-chloride complexes in the respiratory tract, such species having well-known toxic and allergenic effects on human beings and living organisms.
authors.affiliation: Department of Earth Science and Engineering, Imperial College London, London SW7 2AZ, UK. claudia.colombo@ic.ac.uk
authors.forename: Claudia
authors.initials: C
authors.lastname: Colombo
authors.forename: A John
authors.initials: AJ
authors.lastname: Monhemius
authors.forename: Jane A
authors.initials: JA
authors.lastname: Plant
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D004391:Dust / Q000032:analysis; D045604:Extracellular Fluid / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects*; D008954:Models, Biological; D010165:Palladium / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D010984:Platinum / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D012238:Rhodium / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D018570:Risk Assessment; D001335:Vehicle Emissions / Q000032:analysis / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D004391:Dust; D001335:Vehicle Emissions; D010984:Platinum; D010165:Palladium; D012238:Rhodium