title: Effect of complementary and alternative medicine during radiotherapy on radiation toxicity.
abstract: OBJECTIVE
  To examine the frequency and types of complementary and alternative medicine use in patients undergoing radiotherapy and to analyze the effects these therapies have on the toxicities of radiotherapy.
  
  
  METHODS
  A total of 210 consecutive cancer patients undergoing radiation therapy were included. After radiation therapy, each patient completed a standard questionnaire, and the association between radiation toxicity and complementary and alternative medicine use was analyzed.
  
  
  RESULTS
  Among the study population, 44.3% of patients reported using at least one form of complementary and alternative medicine during radiotherapy. The most commonly chosen complementary and alternative medicine was stinging nettle. Complementary and alternative medicine use decreased lower gastrointestinal (F = 3.26, P = .009) and genitourinary toxicities (F = 2.38, P = .043), while it increased laryngeal toxicity (F = 2.63, P = .028). A significant correlation between the type of complementary and alternative medicine used and the degree of these toxicities was not demonstrated.
  
  
  CONCLUSIONS
  Use of complementary and alternative medicine among cancer patients during radiation therapy may affect the degree of radiation toxicity. Further randomized controlled clinical trials are needed to determine the benefits and risks of complementary and alternative medicine use during radiation therapy.
authors.affiliation: Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey. gamzeaksu@gmail.com
authors.forename: Melek Gamze
authors.initials: MG
authors.lastname: Aksu
authors.forename: Hakan Sat
authors.initials: HS
authors.lastname: Bozcuk
authors.forename: Aylin Fidan
authors.initials: AF
authors.lastname: Korcum
mesh_terms: D000529:Complementary Therapies / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy; D008517:Phytotherapy / Q000706:statistics & numerical data; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D026982:Urtica dioica