title: Extraventricular neurocytoma of the spinal cord in a dog.
abstract: Central neurocytoma is a rare, prognostically favorable neuronal tumor of the human central nervous system, typically located intraventricularly near the foramen of Monro. Extraventricular cerebral neurocytomas and spinal tumors have also been reported. To date, however, neurocytomas have not been documented in domestic animal species. In this report, we describe a spinal cord tumor in a dog. The microscopic examination revealed tumor cells forming loosely packed clusters in some areas and palisades in other areas. In addition, they showed fine fibrillary neuropil-like areas of different sizes, sometimes resembling the "rosettes" of pineocytomas, as well as ependymoma-like perivascular pseudorosettes. The tumor cells had scant eosinophilic cytoplasm, with perinuclear halos, closely resembling the appearance of oligodendroglioma. Immunohistochemical staining showed expression of synaptophysin and neuron-specific enolase by tumor cells and pronounced in fibrillary areas. On the basis of histomorphology and immunohistochemical reactivity, the present tumor was diagnosed as extraventricular neurocytoma.
authors.affiliation: Institut für Veterinär-Pathologie, Universität Giessen, Germany. maike.huisinga@vetmed.uni-giessen.de
authors.forename: M
authors.initials: M
authors.lastname: Huisinga
authors.forename: M
authors.initials: M
authors.lastname: Henrich
authors.forename: K
authors.initials: K
authors.lastname: Frese
authors.forename: E
authors.initials: E
authors.lastname: Burkhardt
authors.forename: K
authors.initials: K
authors.lastname: Kuchelmeister
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Reinacher
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D018306:Neurocytoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*