Synthesis using aromatic homolytic substitution--recent advances.
This critical review aims at presenting recent developments in intramolecular aromatic homolytic substitution which has become one of the common methodologies in modern synthesis. The application of Bu3SnH-mediated cyclisations have proved especially useful. The critical review illustrates the mechanistic considerations required for planning synthetic applications and a wide range of synthetic protocols and natural product syntheses are shown. The latest evidence for the mechanisms involved in aromatic homolytic substitution are presented. (152 references).
Bowman
W Russell
WR
Department of Chemistry, Loughborough University, Loughborough, Leicester, UK. w.r.bowman@lboro.ac.uk
Storey
John M D
JM
D003500:Cyclization; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D005609:Free Radicals; D006841:Hydrocarbons, Aromatic