Copper-catalyzed coupling of hydroxylamines with aryl iodides.
An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
Jones
Kerri L
KL
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, United Kingdom.
Porzelle
Achim
A
Hall
Adrian
A
Woodrow
Michael D
MD
Tomkinson
Nicholas C O
NC
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D015394:Molecular Structure
D006847:Hydrocarbons, Iodinated; D006898:Hydroxylamines; D003300:Copper