Synthesis of natural products from the Indian neem tree Azadirachta indica.
The synthesis of five natural products (3, 6, 7, 10, and 14), isolated from the Indian neem tree Azadirachta indica, is reported from a common intermediate (2). The judicious choice of transacetalization conditions allows efficient access to both the azadirachtinin (9 and 10) and the azadirachtin (3, 6, 7, and 14) skeletons.
Veitch
Gemma E
GE
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Pinto
Andrea
A
Boyer
Alistair
A
Beckmann
Edith
E
Anderson
James C
JC
Ley
Steven V
SV
D031601:Azadirachta / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D007194:India; D036701:Limonins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001688:Biological Products; D036701:Limonins; C010329:azadirachtin