Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer.
A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not known yet. This study, with the help of reverse transcription-polymerase chain reaction and immunohistochemistry, is an attempt to document the molecular presence of the hCGbeta and luteinizing hormone/hCG receptor (LH/hCGR) in the ovarian, endometrial, and uterine cervix cancer tissues. The LH/hCGR, coexpressed with hCGbeta, may act as a potential mediator of hCG action in nontrophoblastic gynecological cancers.
Jankowska
A
A
Department of Cell Biology, University of Medical Sciences, Poznan, Poland. ajanko@amp.edu.pl
Andrusiewicz
M
M
Grabowski
J
J
Nowak-Markwitz
E
E
Warchol
J B
JB
D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011974:Receptors, LH / Q000235:genetics / Q000378:metabolism*; D014328:Trophoblastic Neoplasms / Q000235:genetics / Q000378:metabolism; D014594:Uterine Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D018997:Chorionic Gonadotropin, beta Subunit, Human; D011974:Receptors, LH