The impact of medication regimen factors on adherence to chronic treatment: a review of literature.
This article reviews recent literature in chronic illness or long-term health management including asthma, contraception, diabetes, HIV disease, and hypertension/cardiovascular disease, mental disorders, pain, and other diseases to determine the relationship between regimen factors and adherence to medications. The authors conducted an electronic literature search to detect articles published between 1998 and 2007. Articles were included if they pertained to a chronic illness or to contraception, included a clear definition of how adherence was measured, and included regimen factors as primary or secondary explanatory variables. Methodology of the studies varied greatly, as did methods of measuring adherence and regimen factors. Surprisingly few of these articles concerned (1) chronic treatment, (2) regimen factors such as dosing, pill burden, and regimen complexity, and (3) adherence measured in a clear manner. Most studies failed to use state-of-the-art methods of measuring adherence. Despite these flaws, a suggestive pattern of the importance of regimen factors, specifically dose frequency and regimen complexity, emerged from this review.
Ingersoll
Karen S
KS
Department of Psychiatry and Neurobehavioral Science, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA. kareningersoll@gmail.com
Cohen
Jessye
J
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000523:psychology; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects; D002908:Chronic Disease / Q000188:drug therapy* / Q000523:psychology*; D003268:Contraception Behavior; D017281:Cost of Illness; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D009042:Motivation; D010349:Patient Compliance / Q000523:psychology*
D019380:Anti-HIV Agents