[Responses of hemodynamics and splanchnic organ blood flow to esmolol during inhalation of volatile anesthetics in dogs].
BACKGROUND
Because the hemodynamic alterations due to sympathetic suppression by the interaction of esmolol with volatile anesthetics may alter the blood flow to the splanchnic organs, this study was designed to investigate whether esmolol might modify the hemodynamics and splanchnic organ blood flow in anesthetized dogs.


METHODS
Anesthesia was maintained with 0.9% halothane, 1.3% isoflurane or 2.4% sevoflurane (1MAC, n=8, each) in oxygen. Esmolol was infused at a constant rate of 400 microg * kg(-1) x min(-1) during a 60 min-infusion period. The renal, hepatic, and pancreatic blood flows (RBF, HBF, and PBF) were measured by using the hydrogen clearance method.


RESULTS
Mean arterial pressure in all three groups decreased without any changes in heart rate or systemic vascular resistance. Cardiac index in all three groups decreased with reductions in cardiac contractility. The RBF, HBF, and PBF in all three groups were reduced during the esmolol infusion.


CONCLUSIONS
The splanchnic organ blood flow reductions caused by esmolol may be due to cardiac depression, whereas there appears to be no differences in there change regarding the kind of the volatile anesthetics. These findings suggest that hypotension induced by esmolol may impair the maintenance of splanchnic organ blood flow during anesthesia by volatile agents.
Masuda
Rikuo
R
Department of Anesthesia, Showa University Northern Yokohama Hospital, Yokohama.
Takeda
Shohei
S
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics* / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D006221:Halothane / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology; D008738:Methyl Ethers / Q000494:pharmacology; D011412:Propanolamines / Q000493:pharmacokinetics* / Q000494:pharmacology*; D000077149:Sevoflurane; D013152:Splanchnic Circulation / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D011412:Propanolamines; D000077149:Sevoflurane; D007530:Isoflurane; C036604:esmolol; D006221:Halothane