title: 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning.
abstract: We have developed a tumor-specific protocol for the 4D-CT imaging of liver tumors using synchronized intravenous (IV) contrast injection to improve the accuracy of tumor delineation for treatment planning. Most liver metastases and cholangiocarcinomas can be imaged in the portal venous phase, while hepatocellular carcinomas are most visible in the delayed phase. Combined 4D-CT imaging with synchronized IV contrast allows for both enhancement of tumor contrast and coverage over the entire breathing cycle.
authors.affiliation: Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, TX 77030, USA. abeddar@mdanderson.org
authors.forename: A Sam
authors.initials: AS
authors.lastname: Beddar
authors.forename: Tina Marie
authors.initials: TM
authors.lastname: Briere
authors.forename: Peter
authors.initials: P
authors.lastname: Balter
authors.forename: Tinsu
authors.initials: T
authors.lastname: Pan
authors.forename: Naresh
authors.initials: N
authors.lastname: Tolani
authors.forename: Chaan
authors.initials: C
authors.lastname: Ng
authors.forename: Janio
authors.initials: J
authors.lastname: Szklaruk
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy; D003287:Contrast Media / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D011856:Radiographic Image Enhancement; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol