title: Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome.
abstract: The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.
authors.affiliation: Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Rome, Italy. drigante@gmail.com
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Rosanna
authors.initials: R
authors.lastname: Inzitari
authors.forename: Maurizio
authors.initials: M
authors.lastname: Carone
authors.forename: Chiara
authors.initials: C
authors.lastname: Fanali
authors.forename: Achille
authors.initials: A
authors.lastname: Stabile
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cabras
authors.forename: Ettore
authors.initials: E
authors.lastname: Capoluongo
authors.forename: Stefania
authors.initials: S
authors.lastname: Gaspari
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Barone
authors.forename: Massimo
authors.initials: M
authors.lastname: Castagnola
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D040901:Proteomics; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000737:chemistry; D012859:Sjogren's Syndrome / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D010455:Peptides; D012471:Salivary Proteins and Peptides