Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases.
A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune lymphoproliferative syndrome (ALPS).
Oliveira
João Bosco
JB
Molecular Immunology and Genetics Section, Universidade de São Paulo, São Paulo, Brazil.
Gupta
Sudhir
S
D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics; D020169:Caspases / Q000172:deficiency / Q000235:genetics; D053222:Fas Ligand Protein / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009154:Mutation; D015398:Signal Transduction / Q000276:immunology
D015703:Antigens, CD; D053222:Fas Ligand Protein; D020169:Caspases