Neutrophil activation in patients with ASA-induced urticaria.
The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.
Choi
Sung-Jin
SJ
Department of Allergy and Rheumatology, Ajou University School of Medicine, San-5, Wonchondong, Youngtonggu, Suwon, Korea.
Ye
Young-Min
YM
Hur
Gyu-Young
GY
Shin
Seung-Youp
SY
Han
Jae-Ho
JH
Park
Hae-Sim
HS
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000799:Angioedema / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood; D004342:Drug Hypersensitivity / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D008297:Male; D018375:Neutrophil Activation / Q000187:drug effects* / Q000276:immunology*; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*; D009195:Peroxidase / Q000097:blood; D014581:Urticaria / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000473:pathology
D016207:Cytokines; D009195:Peroxidase; D001241:Aspirin