title: Successful boric acid treatment of Aspergillus niger infection in an exenterated orbit.
abstract: Aspergillus niger infection of an exenterated orbit is a very rare occurrence. Treatment includes extensive surgical debridement with socket lavage with 0.6% hydrogen peroxide, oral itraconazole, and local amphotericin B. We describe a case of A. niger infection in an exenterated orbit, unresponsive to local amphotericin B, that was successfully treated with weekly boric acid irrigation. We conclude that local and conservative therapy with 2.5% boric acid solution in 70% ethanol is a useful option in the management of these cases.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, Spain. javino@ono.com
authors.forename: Juan A
authors.initials: JA
authors.lastname: Aviñó-Martínez
authors.forename: Enrique
authors.initials: E
authors.lastname: España-Gregori
authors.forename: Cristina P
authors.initials: CP
authors.lastname: Peris-Martínez
authors.forename: Marino
authors.initials: M
authors.lastname: Blanes
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001234:Aspergillus niger / Q000302:isolation & purification*; D001888:Boric Acids / Q000627:therapeutic use*; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017233:Orbit Evisceration; D009916:Orbital Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D001888:Boric Acids; C032688:boric acid