title: The cysteinyl leukotrienes: where do they come from? What are they? Where are they going?
abstract: Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth muscle and on bone marrow-derived inflammatory cells. K. Frank Austen describes the work culminating in the identification, biosynthesis and functional characterization of these moieties.
authors.affiliation: Department of Medicine, Harvard Medical School and the Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. fausten@rics.bwh.harvard.edu
authors.forename: K Frank
authors.initials: KF
authors.lastname: Austen
mesh_terms: D000707:Anaphylaxis / Q000266:history* / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000266:history* / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D003545:Cysteine / Q000266:history* / Q000378:metabolism; D004739:England; D006168:Guinea Pigs; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007155:Immunologic Factors / Q000266:history* / Q000378:metabolism; D015289:Leukotrienes / Q000266:history* / Q000378:metabolism; D009130:Muscle, Smooth / Q000276:immunology; D051381:Rats; D018077:Receptors, Leukotriene / Q000266:history* / Q000378:metabolism; D014481:United States
chemical_list: D007155:Immunologic Factors; D015289:Leukotrienes; D018077:Receptors, Leukotriene; C112381:cysteinyl-leukotriene; D003545:Cysteine