One-pot, two-step synthesis of substituted anthraquinones from chromium(0) alkynyl carbenes and isobenzofurans.
The reaction of alkynyl Fischer carbenes and isobenzofurans gives rise to the corresponding [4 + 2] cycloadducts. The newly formed carbene adducts are suitable for benzannulation processes in the presence of tert-butylisocyanide or carbon monoxide to yield a variety of new highly substituted polycyclic structures having the anthraquinone framework. The whole two-step process is conducted in a one-pot fashion from easily available 1,4-dihydro-1,4-epoxynaphthalenes.
Barluenga
José
J
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, Spain. barluenga@uniovi.es
Martínez
Silvia
S
Suárez-Sobrino
Angel L
AL
Tomás
Miguel
M