title: Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid.
abstract: A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-alpha (hER-alpha), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Suzuki
authors.forename: Kana
authors.initials: K
authors.lastname: Tsumura
authors.forename: Takeo
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsumura
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D004958:Estradiol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000528:radiation effects; D047628:Estrogen Receptor alpha / Q000737:chemistry* / Q000528:radiation effects; D006801:Humans; D008968:Molecular Conformation; D010777:Photochemistry; D011804:Quinolines / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: C526991:17-(3-((2-phenylquinolin-4-yl)carbonyloxy)propynyl)estradiol; D047628:Estrogen Receptor alpha; D011804:Quinolines; D004958:Estradiol