title: Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome.
abstract: A 6-year-old, sterile, Blanca Celtibérica breed adult doe was referred to our faculty. The doe had external female genitalia, a short anogenital distance, and normally shaped udders. Masculinization signs in the head shape and male behavior were also noted at the time of referral. Genetic analysis demonstrated normal 2n = 60 XX karyotype and an absence of the sex-determining region Y (SRY). The animal was homozygous for a DNA deletion responsible for the Polled Intersex Syndrome (PIS). A uterus and 2 uterine horns were present at the postmortem examination. Gartner's ducts and degenerated Wolffian derivatives persisted. There were 2 intra-abdominal testicle-like structures, one of which consisted of epididymal and deferent ducts. An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed. Leydig cell tumors usually produce testosterone. Thus, these histologic findings are compatible with the evident virilization.
authors.affiliation: Laboratory of Cytogenetics and Molecular Genetics, University of Zaragoza, Faculty of Veterinary Science, Zaragoza, Spain. monteagu@unizar.es
authors.forename: L V
authors.initials: LV
authors.lastname: Monteagudo
authors.forename: M V
authors.initials: MV
authors.lastname: Arruga
authors.forename: J I
authors.initials: JI
authors.lastname: Bonafonte
authors.forename: M
authors.initials: M
authors.lastname: Ordás
authors.forename: A
authors.initials: A
authors.lastname: Whyte
authors.forename: M
authors.initials: M
authors.lastname: Gallego
authors.forename: J A
authors.initials: JA
authors.lastname: Bascuas
authors.forename: I
authors.initials: I
authors.lastname: Sierra
mesh_terms: D000818:Animals; D012734:Disorders of Sex Development / Q000235:genetics / Q000662:veterinary*; D005260:Female; D015511:Goat Diseases / Q000175:diagnosis* / Q000235:genetics; D006041:Goats; D007984:Leydig Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*