title: Fructose-induced breath hydrogen in patients with fruit intolerance.
abstract: OBJECTIVE
  To measure bloating score, flatus passage, and hydrogen production after oral fructose in patients with history of fruit intolerance and compare these parameters with those in normal controls.
  
  
  BACKGROUND
  Some patients complain of abdominal distention and excessive flatus after ingesting certain fruits such as mango, persimmon, and grapes but not after eating apricots and melon.
  
  
  METHODS
  We recorded breath hydrogen, flatus passage and bloating after 20 g fructose in 8 patients with history of fruit intolerance and 4 healthy controls. Breath hydrogen was measured every 15 minutes for 480 minutes using EC-60 gastrolyzer. Number of passage of flatus was recorded over 8 hours. Severity of abdominal distention on a scale of 1 to 10 was noted.
  
  
  RESULTS
  The patients with fruit intolerance produced breath hydrogen 1745.2+/-7.8 parts per million, passed flatus 13.8+/-0.3 times, and had bloating score of 5.7+/-0.1. The healthy controls produced breath hydrogen 712.5+/-5.8 parts per million in 8 hours, passed flatus 7.2+/-0.5 time, and had bloating score of 2.7+/-0.2.
  
  
  CONCLUSIONS
  After 20 g fructose, patients with history of fruit intolerance produce more breath hydrogen, pass flatus more frequently, and have a higher bloating score compared with healthy controls.
authors.affiliation: Division of Gastroenterology, Davis School of Medicine, University of California, USA. nirmal.mann@ucdmc.ucdavis.edu
authors.forename: Nirmal S
authors.initials: NS
authors.lastname: Mann
authors.forename: Eddie C
authors.initials: EC
authors.lastname: Cheung
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods*; D004415:Dyspepsia / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D005414:Flatulence / Q000209:etiology; D005632:Fructose / Q000378:metabolism*; D005638:Fruit / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D005632:Fructose; D006859:Hydrogen