title: Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases.
abstract: A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune lymphoproliferative syndrome (ALPS).
authors.affiliation: Molecular Immunology and Genetics Section, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: João Bosco
authors.initials: JB
authors.lastname: Oliveira
authors.forename: Sudhir
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics; D020169:Caspases / Q000172:deficiency / Q000235:genetics; D053222:Fas Ligand Protein / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009154:Mutation; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015703:Antigens, CD; D053222:Fas Ligand Protein; D020169:Caspases