title: Nurofen Plus misuse: an emerging cause of perforated gastric ulcer.
abstract: Over a 6-month period, two patients presented to a community hospital emergency department with perforated gastric ulcers as the result of recreational misuse of over-the-counter ibuprofen-codeine preparations. Misuse of these medications appears to be an emerging cause of significant morbidity in patients with codeine addiction.
authors.affiliation: Emergency Department, The Angliss Hospital, Melbourne, VIC, Australia. martin.dutch@mh.org.au
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Dutch
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003061:Codeine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D004366:Nonprescription Drugs; D010439:Peptic Ulcer Perforation / Q000139:chemically induced*; D011027:Pneumoperitoneum / Q000000981:diagnostic imaging; D011859:Radiography; D013276:Stomach Ulcer / Q000139:chemically induced*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004366:Nonprescription Drugs; D003061:Codeine; D007052:Ibuprofen