Total synthesis of the C-1027 chromophore core: extremely facile enediyne formation through Sml2-mediated 1,2-elimination.
Inoue
Masayuki
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. inoue@mol.f.u-tokyo.ac.jp
Ohashi
Isao
I
Kawaguchi
Teruko
T
Hirama
Masahiro
M
D000617:Aminoglycosides / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D053281:Enediynes / Q000138:chemical synthesis*; D015394:Molecular Structure; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry
D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; C058024:C 1027; D014050:Toluene; C028383:4-(trifluoromethyl)benzoic acid