"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.
Szekely
Jozsef
J
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Institute of Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37235-1822, USA.
Wang
Hao
H
Peplowski
Katherine M
KM
Knutson
Charles G
CG
Marnett
Lawrence J
LJ
Rizzo
Carmelo J
CJ
D018736:DNA Adducts / Q000138:chemical synthesis* / Q000737:chemistry; D008315:Malondialdehyde / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D018736:DNA Adducts; D009705:Nucleosides; D008315:Malondialdehyde