Tissue development and RNA control: "HOW" is it coordinated?
The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.
Volk
Talila
T
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. lgvolk@weizmann.ac.il
Israeli
David
D
Nir
Ronit
R
Toledano-Katchalski
Hila
H
D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D010641:Phenotype; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D013710:Tendons / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
D029721:Drosophila Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C106296:how protein, Drosophila; D012313:RNA