A new cytotoxic, apoptosis-inducing triterpenoid from the rhizomes of Astilbe chinensis.
A new ursane-based compound, astilbotriterpenic acid (1), was isolated from the rhizomes of Astilbe chinensis. Its structure was determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D- and 2D-NMR. The pentacyclic triterpenoid 1 was assayed for its in vitro cytotoxicity against Bcap37, HeLa, HepG2, HO-8910, K562, PAA, SGC7901, and P388 cancer cells, as well as for its apoptosis-inducing activity in HeLa cells. Compound 1 was found to strongly inhibit tumor-cell growth through induction of apoptosis and may, thus, be further evaluated as a novel chemotherapeutic agent.
Zhang
Yi-Bin
YB
College of Animal Sciences, Zhejiang University, Hangzhou 310029, PR. China.
Peng
Xiao-Ying
XY
Sun
Hong-Xiang
HX
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D000091402:Prohibitins; D012015:Reference Standards; D027343:Rhizome / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C527656:3,6-dihydroxyurs-12-en-27-oic acid; C000717331:PHB2 protein, human; D000091402:Prohibitins; D014315:Triterpenes