[Morphological changes in the thymus during the physical loads applied simultaneously with the administration of diucifon and in the rehabilitation period].
The peculiarities of structure and cellular composition of the thymus in male Wistar rats were studied using histological, morphometric methods and electron microscopy during the adaptation to physical loads (swimming), which were applied simultaneously with the administration of the immunomodulator diucifon and in the late stages of a rehabilitation period after cessation of the training process. Training performed with the simultaneous correction with diucifon resulted in the changes that were indicative of the increased reserve capacity of the immune system (increase in the relative area of the cortex in thymus sections, augmentation of the number of blast cells, medium lymphocytes and mitotically dividing cells). The degree of these changes was different in animals with various adaptation capacity, which is indicative of the necessity of immunomodulator administration considering an individual organism response to physical loads. 5 weeks after cessation of the training, in 75% of animals that were trained without correctrion, the signs of thymic involution (increase in the amount of adipose tissue, thickening of interlobular septae) were more expressed than in the animals of control group. In rats that received diucifon, thymus structure and cellular composition were similar to those in the control group.
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D000222:Adaptation, Physiological; D000818:Animals; D004338:Drug Combinations; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013450:Sulfones / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D004338:Drug Combinations; D007155:Immunologic Factors; D013450:Sulfones; C023367:diucifon; D014498:Uracil