Tetraspanins-structural and signalling scaffolds that regulate platelet function.
There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the 'outside-in' signalling properties of the major platelet integrin, integrin alpha(IIb)beta(3) and thrombus stability in vivo.
Goschnick
Matt W
MW
Immunoreceptor Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg, Victoria 3084, Australia.
Jackson
Denise E
DE
D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
D008565:Membrane Proteins