title: [A spectrum of neurological diseases with anti-VGKC antibody].
abstract: Anti-VGKC antibody causing peripheral nerve hyperexcitability is already an established clinical entity. Recently, many patients with non-herpetic limbic encephalitis (NHLE) with anti-VGKC antibody have been reported. The characteristic clinical features are low serum Na+ concentration and good response to immunotherapy. Anti-VGK antibody positive NHLE is relatively frequent among immune-mediated NHLE. It is important to know that this disease is responsive to immunotherapy. Furthermore, anti-VGKC antibody is also positive in some intractable epilepsies. These findings suggest that anti-VGKC is correlated with hyperexcitability in both the peripheral and central nervous system and that the spectrum of anti-VGKC antibody syndrome is now expanding.
authors.affiliation: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences.
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Tatsui
authors.initials: T
authors.lastname: Nagado
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D004827:Epilepsy / Q000276:immunology; D006801:Humans; D020363:Limbic Encephalitis / Q000276:immunology; D009422:Nervous System Diseases / Q000276:immunology*; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated