title: [Involvement of hypothalamopituitary adrenal axis in abdominal obesity].
abstract: Obesity is increasing worldwide. Abdominal obesity, which is due to the development of visceral adipose tissue, leads to metabolic disorders. Because abdominal obesity is associated with Cushing syndrome, many studies have been performed to find out how the hypothalamopituitary adrenal axis is involved in this disorder. Here, we propose to review these data before giving our experience on changes in hypothalamopituitary adrenal axis activity regarding fat mass distribution in prepubertal children.
authors.affiliation: Endocrinologie et diabétologie de l'enfant et de l'adolescent, hôpital des enfants, CHU de Bordeaux, place Amélie-Raba-Léon, Bordeaux cedex, France. pascal.barat@chu-bordeaux.fr
authors.forename: P
authors.initials: P
authors.lastname: Barat
authors.forename: M
authors.initials: M
authors.lastname: Duclos
authors.forename: M-P
authors.initials: MP
authors.lastname: Moisan
authors.forename: P
authors.initials: P
authors.lastname: Mormède
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000502:physiology; D050153:Abdominal Fat / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D002648:Child; D004195:Disease Models, Animal; D005006:Ethnicity; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000502:physiology; D012737:Sex Factors
chemical_list: D011965:Receptors, Glucocorticoid; D042842:11-beta-Hydroxysteroid Dehydrogenases; D006854:Hydrocortisone