Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome.
The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.
Rigante
Donato
D
Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Rome, Italy. drigante@gmail.com
Inzitari
Rosanna
R
Carone
Maurizio
M
Fanali
Chiara
C
Stabile
Achille
A
Cabras
Tiziana
T
Capoluongo
Ettore
E
Gaspari
Stefania
S
Barone
Giuseppe
G
Castagnola
Massimo
M
D016022:Case-Control Studies; D002648:Child; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D040901:Proteomics; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000737:chemistry; D012859:Sjogren's Syndrome / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
D010455:Peptides; D012471:Salivary Proteins and Peptides