Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice.
The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic receptors). Our results confirmed the presence of choline-positive effect in dipeptide piracetam analogue Noopept on retrieval of learned skill of finding a submerged platform (spatial memory). We conclude that the effectiveness of this drug should be evaluated in patients with Alzheimer's disease.
Belnik
A P
AP
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Ostrovskaya
R U
RU
Poletaeva
I I
II
D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D018696:Neuroprotective Agents / Q000494:pharmacology; D018697:Nootropic Agents / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects*
D004151:Dipeptides; D018696:Neuroprotective Agents; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D012601:Scopolamine