title: CD117 immunoreactivity in atypical fibroxanthoma.
abstract: Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX.
authors.affiliation: Department of Pathology, University of South Florida College of Medicine, Tempa, FL 33612, USA.
authors.forename: Rahel A
authors.initials: RA
authors.lastname: Mathew
authors.forename: Scott M
authors.initials: SM
authors.lastname: Schlauder
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Calder
authors.forename: Michael B
authors.initials: MB
authors.lastname: Morgan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit