Identification of novel drug targets for angiostatic cancer therapy; it takes two to tango.
The development of novel treatment strategies for therapy of angiogenesis-dependent diseases requires identification of specific tumor endothelial cell markers to which therapeutic agents can be targeted. This can be achieved by random or targeted approaches. Random approaches are based on genomic screening to identify differences between normal and activated endothelium. Targeted approaches utilize known angiogenesis inhibitors to find their molecular targets. Both approaches may lead to the development of angiostatic therapies that are directly targeted towards activated endothelial cells. This review summarizes the recent developments in both approaches.
Thijssen
Victor L J L
VL
Angiogenesis Laboratory, Department of Pathology, Maastricht University & University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
van Beijnum
Judy R
JR
Mayo
Kevin H
KH
Griffioen
Arjan W
AW
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D042501:Angiogenic Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D043165:Angiostatic Proteins / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods*
D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D043165:Angiostatic Proteins; D000970:Antineoplastic Agents