title: Normal intelligence and social interactions in a male patient despite the deletion of NLGN4X and the VCX genes.
abstract: Xp22.3 deletion in males can be associated with short stature (SHOX), chondrodysplasia punctata (ARSE), mental retardation (MRX49 locus), ichthyosis (STS), Kallmann syndrome (KAL1) and ocular albinism (OA1), according to the size of the deletion. Studies of terminal and interstitial deletions in male patients with a partial nullisomy of the X chromosome have led to the identification of the VCX-3A gene at the MRX49 locus on Xp22.3. The NLGN4X gene has then been identified less than 350 kb away from VCX-3A. Nonsense mutations in NLGN4X have been associated with autism and/or moderate mental retardation in males. We report a 17-year old male patient presenting with severe ichthyosis and Kallmann syndrome related to a 3.7 Mb interstitial Xp22.3 deletion, encompassing STS and KAL1 genes, respectively. However, despite the deletion of NLGN4X and all VCX genes, including VCX-3A, our patient did not manifest any learning disabilities or behavioural problems. Therefore, our case argues against a major role of NLGN4X and the VCX genes alone in cognitive development and/or communication processes.
authors.affiliation: INSERM U679, Hôpital de la Salpêtrière, Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Mochel
authors.forename: Chantal
authors.initials: C
authors.lastname: Missirian
authors.forename: Rachel
authors.initials: R
authors.lastname: Reynaud
authors.forename: Anne
authors.initials: A
authors.lastname: Moncla
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000293:Adolescent; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D015816:Cell Adhesion Molecules, Neuronal; D041321:Chromosomes, Human, X / Q000235:genetics; D006801:Humans; D007057:Ichthyosis / Q000235:genetics; D008607:Intellectual Disability / Q000235:genetics; D007360:Intelligence / Q000235:genetics*; D007398:Interpersonal Relations; D017436:Kallmann Syndrome / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D002352:Carrier Proteins; D015816:Cell Adhesion Molecules, Neuronal; D008565:Membrane Proteins; C430845:NLGN4X protein, human; D009687:Nuclear Proteins; C404411:VCX protein, human