Transition metal-free addition of ketones or nitriles to 1,3-dienes.
The simpler the better (or going green): The first examples of the catalytic addition of 1,3-dienes to simple ketones or nitriles are described. These reactions can be effected on a kilogram scale, representing the shortest access featuring a perfect atom economy to molecules of interest in the perfume industry.
Gaudin
Jean-Marc
JM
Firmenich SA, Corporate R&D Division, P. O. Box 239, CH-1211, Geneva 8, Switzerland.
Millet
Pascal
P
D000466:Alkadienes / Q000737:chemistry*; D000440:Butanols / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D028561:Transition Elements / Q000737:chemistry
D000466:Alkadienes; D000440:Butanols; D007659:Ketones; D009570:Nitriles; D028561:Transition Elements; C077664:tert-butoxide, potassium