Evaluation of a continuous regimen of levonorgestrel/ethinyl estradiol for contraception and control of menstrual symptoms.
Considerable recent interest has focused on new methods of delivery of oral contraceptives that reduce or eliminate the hormone-free interval in order to improve convenience and acceptability, but maintain contraceptive efficacy, minimize side effects and reduce or eliminate the frequency of withdrawal bleeding episodes. Studies in several countries, including the US, have documented that many women would prefer to have no episodes of withdrawal bleeding when using oral contraceptives. This review focuses on a unique oral contraceptive formulation containing levonogestrel 90 microg and ethinyl estradiol 20 microg, approved for use in a continuous dosing regimen designed to eliminate withdrawal bleeding throughout the entire year.
Jensen
Jeffrey T
JT
Oregon Health & Science University, Department of Ob/Gyn, UHN-70, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. jensenje@ohsu.edu
Archer
David F
DF
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage*; D008598:Menstruation / Q000187:drug effects* / Q000378:metabolism; D008599:Menstruation Disturbances / Q000188:drug therapy* / Q000378:metabolism; D008796:Metrorrhagia / Q000453:epidemiology / Q000517:prevention & control
D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D004997:Ethinyl Estradiol; D016912:Levonorgestrel