title: HELLP syndrome - a multisystemic disorder.
abstract: HELLP syndrome is a multisystemic disorder with an incidence of 0.17-0.85% of all pregnancies. Its etiopathogenesis is not completely understood. The most widely accepted hypotheses are: a change in the immune feto-maternal balance, platelet aggregation, endothelial dysfunction, arterial hypertension and an inborn error of the fatty acid oxidative metabolism. Hepatic involvement occurs by intravascular fibrin deposition and hypovolemia. Materno-fetal complications cause a 6.7-70% perinatal mortality rate and a 1-24% maternal mortality rate. The recognition of HELLP syndrome and the rapid initiation of therapy are required for the improvement of materno-fetal prognosis.
authors.affiliation: Clinic of Obstetrics-Gynecology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
authors.forename: Nicolae
authors.initials: N
authors.lastname: Costin
authors.forename: Carmen Mihaela
authors.initials: CM
authors.lastname: Mihu
authors.forename: Andrada
authors.initials: A
authors.lastname: Seicean
authors.forename: Razvan
authors.initials: R
authors.lastname: Ciortea
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology; D011247:Pregnancy; D015995:Prevalence; D011379:Prognosis