[Contribution of GABA receptors in extinction of memory trace in norm and depressive-like state].
The dependence of activation and blockade of GABA receptors influences on extinction of passive avoidance response from a type of receptors and initial psychoemotional state of mice is shown. The activation of GABAA receptors by muscimol disrupted extinction in norm and did not influence on delay of this process at mice with "behavioral despair". The activation of GABAB receptors by baclofen accelerated extinction of fair memory at mice with depressive-like state. The blockade of GABAA receptors by bicuculline was ineffective in modification of extinction. The blockade of GABAB receptors by phaclofen promoted retention of fear expression at intact mice and facilitation of extinction at "depressive" mice.
Dubrovina
N I
NI
Zinov'ev
D R
DR
D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology; D003863:Depression / Q000378:metabolism* / Q000503:physiopathology; D005239:Fear / Q000187:drug effects; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism*
D018755:GABA Agonists; D018756:GABA Antagonists; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; C052329:phaclofen; D009118:Muscimol; D001418:Baclofen; D001640:Bicuculline