Lymphotropic effect of dimephosphon, mexidol, and ketorolac is realized via activation of the lymphangion and stimulation of lymph formation.
Single parenteral administration of dimephosphon, mexidol, and ketorolac produces a lymphotropic effect. Dimephosphon directly affects the lymph system by increasing the number of functioning lymph capillaries and contractile activity of the walls and valves of small intestinal mesenteric lymphangions in rats, which leads to stimulation of lymph circulation. Mexidol and ketorolac increased only lymph flow rate in the thoracic lymph duct, which attested to their indirect effect of the lymph system (presumably associated with stimulation of lymph formation). Despite these differences in the mechanisms of lymphotropic effect, all these drugs activate lymph drainage and, hence, transporting function of the lymph system.
Khafiz'yanova
R Kh
RKh
Department of Pharmacology, Kazan State Medical University. fimka54@mail.ru
Aleyeva
G N
GN
Mukhutdinov
D A
DA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D020910:Ketorolac / Q000494:pharmacology*; D008196:Lymph / Q000166:cytology / Q000187:drug effects*; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology; D042601:Lymphatic Vessels / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D009943:Organophosphorus Compounds; D010847:Picolines; C049638:dimephosphon; C070020:emoxypine succinate; D020910:Ketorolac