title: Innovative cancer treatments that augment radiotherapy or chemo-therapy by the use of immunotherapy or gene therapy.
abstract: Cancer is a complex multifactorial disease requiring combinations of several therapeutic modalities to treat it effectively. Despite advances in the field of prevention and treatment of cancer, morbidity and mortality remain high, especially for tumors that cannot be completely removed, as well as for those that are highly recurrent or highly metastatic. Surgery, radiotherapy and chemotherapy, alone or in combination, are currently the prevalent treatment modalities. Yet, in order to treat metastases more effectively, the immune response must be recruited. In this review, we will focus on recent patents in the field of cancer that have concentrated on combining chemotherapy or radiotherapy strategies with immunotherapy, in order to eradicate the primary tumor as well as its metastases.
authors.affiliation: Medical and Pharmaceutical Biotechnology, University of Applied Sciences, Krems 3500, Austria.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lucas
authors.forename: Yona
authors.initials: Y
authors.lastname: Keisari
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016207:Cytokines / Q000627:therapeutic use; D015316:Genetic Therapy; D006801:Humans; D007109:Immunity / Q000528:radiation effects; D007167:Immunotherapy; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D010330:Patents as Topic; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
chemical_list: D000912:Antibodies, Neoplasm; D016207:Cytokines; D011838:Radiation-Sensitizing Agents