title: Simultaneous occurrence of infantile hemangioma and congenital melanocytic nevus: Coincidence or real association?
abstract: Both infantile hemangiomas (IH) and congenital melanocytic nevi (CMN) are common birthmarks that affect approximately 4% to 5% of infants and 1% of newborns, respectively. No previous association has been established between these birthmarks. We report a series of 6 patients who were remarkable for either the proximity or extent of anatomic involvement of their IH and CMN. Patient 1 had a large CMN in the area of her left eye and upper face in addition to a parotid IH. Likewise, patient 5 had a giant CMN on her back and a beard distribution IH. Patients 2, 3, and 4 were found to have small CMNs and localized IH in close anatomic proximity. Patient 6 was seen for a large left parietal scalp CMN with satellite nevi and multiple cutaneous hemangiomas. Although IH and CMN are common birthmarks, the clinical characteristics in these cases suggest a real, not coincidental association. Possible pathogenetic mechanisms to explain this association are discussed.
authors.affiliation: Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Peggy A
authors.initials: PA
authors.lastname: Wu
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Mancini
authors.forename: Ashfaq A
authors.initials: AA
authors.lastname: Marghoob
authors.forename: Ilona J
authors.initials: IJ
authors.lastname: Frieden
mesh_terms: D002675:Child, Preschool; D005260:Female; D006391:Hemangioma / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053685:Laser Therapy; D008297:Male; D009508:Nevus, Pigmented / Q000150:complications / Q000151:congenital*