Quantitative measurement of protease ligand conformation.
The tendency for protease ligands to bind in an extended conformation has been suggested as an important factor for the identification of compounds of medicinal importance. Here we present a novel graph-theoretical method giving a quantitative measure of ligand conformation, and through application of this method to a representative set of protease ligands in bound and unbound conformations, derive the result that protease ligands are more extended in conformation when in their bound state.
Illingworth
Christopher J R
CJ
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
Parkes
Kevin E B
KE
Snell
Christopher R
CR
Reynolds
Christopher A
CA
D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D010447:Peptide Hydrolases / Q000378:metabolism*
D008024:Ligands; D010447:Peptide Hydrolases