Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in patients with uterine cervix neoplasia.
OBJECTIVE
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities, in the platelets and serum, were examined in patients with uterine cervix neoplasia without treatment as well as in patients treated by conization or radiotherapy (RTX).


METHODS
The patients were divided based on the amount of time from the end of the treatments until the day of the blood sampling. Groups I (n=19) (conization) and III (n=11) (radiotherapy) (treated from one to five years earlier), groups II (n=19) (conization) and IV (n=16) (radiotherapy) (treated recently; up to three months earlier) and the non-treated group (cancer) (n=7).


RESULTS
E-NPP and ADA in the platelets and E-NPP in the serum were decreased in all the treated groups in relation to the control and non-treated groups, while ADA in the serum was decreased only in the conization groups in relation to them. In group II, E-NPP and ADA, in the platelets, were increased in relation to group IV.


CONCLUSIONS
The tendency of reduction for E-NPP and ADA indicates that they may act together to control nucleotide levels and it may also be speculated that surgery causes greater platelet activation contributing to the changes seen in the conization groups. In this sense, platelets seem to be more sensitive than serum.
Acosta Maldonado
Paula
P
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil.
de Carvalho Corrêa
Maísa
M
Vargas Becker
Lara
L
Flores
Clóvis
C
Beatriz Moretto
Maria
M
Morsch
Vera
V
Chitolina Schetinger
Maria Rosa
MR
D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010727:Phosphoric Diester Hydrolases / Q000097:blood*; D011755:Pyrophosphatases / Q000097:blood*; D013223:Statistics as Topic; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000201:enzymology* / Q000473:pathology
D010727:Phosphoric Diester Hydrolases; D000243:Adenosine Deaminase; D011755:Pyrophosphatases