title: Serum thyrotropin levels predict all-cause and circulatory mortality in patients with invasively treated coronary artery disease.
abstract: The aim of the present study was to analyze the relation of low or high serum thyrotropin (TSH) with mortality in patients with invasively treated coronary artery disease. We followed-up 942 patients who underwent coronary angioplasties or coronary artery bypass graft surgery over a mean follow-up period of 6.4+/-1.6 years. The study population was divided into three groups using the reference limits of serum TSH (0.25-2.12 mIU/l) as cut-offs. There were 118 patients (12.5%) with low and 125 patients (13.3%) with high serum TSH. One hundred and seventy-four subjects (18.5%) deceased during follow-up. Multivariable analyses revealed that both subjects with low and high serum TSH had a lower all-cause and circulatory mortality than subjects with serum TSH within the reference range. We conclude that low and high serum TSH levels are associated with a reduced all-cause and circulatory mortality in patients with coronary artery disease.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.forename: Dirk
authors.initials: D
authors.lastname: Menzel
authors.forename: Julia
authors.initials: J
authors.lastname: Henzler
authors.forename: Daniel
authors.initials: D
authors.lastname: Robinson
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Motz
authors.forename: Rainer
authors.initials: R
authors.lastname: Rettig
authors.forename: Marcus
authors.initials: M
authors.lastname: Dörr
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001775:Blood Circulation / Q000502:physiology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*
chemical_list: D015415:Biomarkers; D013972:Thyrotropin