Genetic background and the dilemma of translating mouse studies to humans.
C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.
Rivera
Juan
J
Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. juan_rivera@nih.gov
Tessarollo
Lino
L
D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D005823:Genetics; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*