Topiramate does not alter nicotine or cocaine discrimination in rats.
The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not produce any nicotine-like or cocaine-like discriminative effects by itself and did not produce any shift in the dose-response curves for nicotine or cocaine discrimination. Thus, the ability to discriminate the effects of nicotine or cocaine does not appear to be altered by topiramate administration. Furthermore, topiramate, given either alone or in combination with nicotine or cocaine, did not depress rates of responding. These experiments indicate that topiramate does not enhance or reduce the ability of rats to discriminate the effects of nicotine or cocaine.
Le Foll
Bernard
B
Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA. bernard_lefoll@camh.net
Justinova
Zuzana
Z
Wertheim
Carrie E
CE
Barnes
Chanel
C
Goldberg
Steven R
SR
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077236:Topiramate
D000927:Anticonvulsants; D018765:Dopamine Uptake Inhibitors; D018722:Nicotinic Agonists; D000077236:Topiramate; D005632:Fructose; D009538:Nicotine; D003042:Cocaine