Measurable serum markers of oxidative stress response in women with endometriosis.
OBJECTIVE
To evaluate the hypothesis of increased systemic oxidative stress in patients with endometriosis.


METHODS
Tertiary care university hospital.


METHODS
Cross-sectional study.


METHODS
Sixty-six women of reproductive age undergoing laparoscopy.


METHODS
All women were investigated for endometriotic foci during laparoscopy. Forty-five women had laparoscopically and histologically confirmed endometriosis, and 21 women did not have endometriosis.


METHODS
Four markers of oxidative stress were assessed in the serum of each patient: heat shock protein 70 (HSP70), HSP70b', thioredoxin (TRX), and ischemia-modified albumin (IMA).


RESULTS
Mean serum HSP 70b' level was higher in patients with endometriosis compared with controls (0.178 ng/mL, SD 0.103, and 0.135 ng/mL, SD 0.014, respectively). The disease stage did not affect HSP70b' levels. Heat shock protein 70, IMA, and TRX levels did not differ between patients with endometriosis and controls. Women with a history of arterial hypertension had higher mean IMA levels compared with women with normal blood pressure independently of the presence of endometriosis (106.7 [SD 25.4] U/mL and 85.0 [SD 11.5] U/mL, respectively).


CONCLUSIONS
Endometriosis is associated with increased systemic oxidative stress. The implication of increased systemic oxidative stress in disease progression or the association with other oxidative stress-related pathologic conditions needs to be addressed in further studies.
Lambrinoudaki
Irene V
IV
Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece. ilambrinoudaki@hotmail.com
Augoulea
Areti
A
Christodoulakos
George E
GE
Economou
Emmanuel V
EV
Kaparos
George
G
Kontoravdis
Antonios
A
Papadias
Constantinos
C
Creatsas
George
G
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D010535:Laparoscopy; D008597:Menstrual Cycle / Q000502:physiology; D018384:Oxidative Stress; D010298:Parity; D011247:Pregnancy; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism*; D013879:Thioredoxins / Q000097:blood*
D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; C491129:HSPA7 protein, human; D012709:Serum Albumin; D013879:Thioredoxins