title: Robustness of linkage maps in natural populations: a simulation study.
abstract: In a number of long-term individual-based studies of vertebrate populations, the genealogical relationships between individuals have been established with molecular markers. As a result, it is possible to construct genetic linkage maps of these study populations by examining the co-segregation of markers through the pedigree. There are now four free-living vertebrate study populations for whom linkage maps have been built. In this study, simulation was used to investigate whether these linkage maps are likely to be accurate. In all four populations, the probability of assigning markers to the correct chromosome is high and framework maps are generally inferred correctly. However, genotyping error can result in incorrect maps being built with very strong statistical support over the correct order. Future applications of linkage maps of natural populations are discussed.
authors.affiliation: Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. j.slate@sheffield.ac.uk
authors.forename: Jon
authors.initials: J
authors.lastname: Slate
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000592:standards / Q000662:veterinary*; D002875:Chromosomes; D003198:Computer Simulation; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D018895:Microsatellite Repeats; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D014714:Vertebrates / Q000235:genetics
chemical_list: D005819:Genetic Markers