Inhibition of dermal MRSA colonization by microalgal micro- and nanoparticles.
The aim of this study was to investigate the prevention of the dermal colonization of methicillin-resistant Staphylococcus aureus (MRSA) strains by the application of micro- and nanoparticles called Maresometrade mark. Maresometrade mark were prepared from selected microalgae by a novel emulsion technique. They contain lipids and all other components of the microalgae in an encapsulated form. It could be shown that Maresometrade mark prepared from a cyanobacterial strain of the order Nostocales (Bio33-Maresometrade mark) were able to inhibit the dermal colonization of different MRSA strains (North German Epidemic Strain, Col, N315) and even of the vancomycin-resistant strain MU50 in the models 'mouse ear' and 'cow udder teat'. Pretreatment of the skin with Maresometrade mark reduced the number of attached MRSA by 3-4 log units in comparison to the control. We assume that a prophylactic skin care with Maresometrade mark could complete the multibarrier anti-infectious strategy against MRSA.
Lukowski
G
G
Institute of Marine Biotechnology e.V., Greifswald, Germany. lukowski@uni-greifswald.de
Lindequist
U
U
Mundt
S
S
Kramer
A
A
Julich
W-D
WD
D046868:Anabaena cylindrica; D000818:Animals; D002417:Cattle; D004337:Drug Carriers; D004339:Drug Compounding; D004431:Ear, External; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D008321:Mammary Glands, Animal; D016106:Methicillin Resistance; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D012867:Skin / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000502:physiology*
D004337:Drug Carriers; D005227:Fatty Acids