Long-term anti-rabies antibody persistence following intramuscular or low-dose intradermal vaccination of young Vietnamese children.
Vietnamese children received purified Vero cell rabies vaccine 1 year after a primary series (Y0) and again 5 years later (Y5), either as intramuscular or 1/5th dose intradermal injections concomitant with diphtheria, tetanus, pertussis and oral poliomyelitis vaccines. Antibody levels were assayed annually for 5 years. All subjects in both groups had anti-rabies antibody titres considered protective after the Y0 booster. Rabies seroprotection rates and geometric mean titres gradually decreased similarly in both groups. Seroprotection after the Y5 booster was 100% in both groups. Satisfactory immunogenicity, long-term antibody persistence and an anamnestic response were conferred by both routes, greatly simplifying any future post-exposure prophylaxis.
Vien
Nguyen Cong
NC
Center of Pediatrics, Development and Health, Children's Hospital No. 2, Ho Chi Minh City, Viet Nam.
Feroldi
Emmanuel
E
Lang
Jean
J
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002522:Chlorocebus aethiops; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013223:Statistics as Topic; D014709:Vero Cells; D014744:Vietnam
D000914:Antibodies, Viral; D011819:Rabies Vaccines