title: In vivo proton spectroscopy of giant cell tumor of the bone.
abstract: OBJECTIVE
  The proton MR spectroscopic finding of elevated choline has been reported to be useful in the differentiation of malignant from benign musculoskeletal tumors. This study was designed to evaluate the MR spectroscopy features of giant cell tumor (GCT) of the bone, primarily to determine whether the presence of choline is a frequent occurrence in these tumors and whether MR spectroscopy features can be correlated with clinical, radiologic, and histopathologic findings.
  
  
  METHODS
  MRI, dynamic contrast-enhanced MRI, and proton MR spectroscopy were performed in 33 patients with bone tumors on a 1.5-T MR scanner. Of these, 12 patients who had GCT of the bone form the subject material for this study. Dynamic contrast-enhanced MRI and single-voxel proton MR spectroscopy were performed after preliminary evaluation with radiography. Patients were divided into two groups, those with elevated choline levels and those without a choline peak on MR spectroscopy. The clinical and radiologic features, including the Campanacci stage and dynamic MRI findings, were compared in these two groups. Core biopsy was performed in all patients, and in 10 of 12 patients, histopathologic evaluation of the postoperative resected specimen was also performed.
  
  
  RESULTS
  Although all 12 tumors were benign on histopathology, four had elevated choline levels. Of these, three (75%) had an aggressive radiographic appearance (Campanacci stage 3). As opposed to this, only three of the eight (37.5%) tumors without a choline peak had an aggressive radiographic appearance. Except for a single case, all tumors showed early enhancement and washout of contrast material on dynamic MRI.
  
  
  CONCLUSIONS
  The results of this study indicate that GCT of bone may show raised choline levels on proton MR spectroscopy. This finding is not an indicator of malignancy in these tumors.
authors.affiliation: Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar AIIMS, New Delhi, India.
authors.forename: Panna Lal
authors.initials: PL
authors.lastname: Sah
authors.forename: Raju
authors.initials: R
authors.lastname: Sharma
authors.forename: Harsh
authors.initials: H
authors.lastname: Kandpal
authors.forename: Ashu
authors.initials: A
authors.lastname: Seith
authors.forename: Shishir
authors.initials: S
authors.lastname: Rastogi
authors.forename: Suman
authors.initials: S
authors.lastname: Bandhu
authors.forename: N R
authors.initials: NR
authors.lastname: Jagannathan
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D018286:Carcinoma, Giant Cell / Q000175:diagnosis* / Q000378:metabolism*; D002648:Child; D002794:Choline / Q000032:analysis*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D011522:Protons; D002794:Choline