Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in a previously healthy 35-year-old woman.
This case report describes a previously healthy 35-year-old woman, with an episode of fever, neutropenia, thrombocytopenia and elevation of biochemical markers of liver injury, 10 days after beginning drug therapy with dexketoprofen trometamol. Infectious and autoimmune causes of neutropenia, and viral or autoimmune hepatitis were excluded. The resolution following withdrawal of dexketoprofen trometamol confirms the possibility of an adverse drug reaction.
Zabala
S
S
Service of Internal Medicine, Hospital Obispo Polanco, Teruel, Spain. szabala@salud.aragon.es
Calpe
M J
MJ
Pérez
G
G
Lerín
F J
FJ
Mouronval
L
L
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000031:analogs & derivatives*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D009503:Neutropenia / Q000139:chemically induced*; D013921:Thrombocytopenia / Q000139:chemically induced*; D014325:Tromethamine / Q000009:adverse effects / Q000031:analogs & derivatives*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol