Signet ring-like cells in pituitary adenoma.
We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems. The patient had received clomiphen citrate and human chorionic gonadotrophin for 3 years. Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells. The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin. The clinicopathologic features and diagnostic difficulties of this rare entity are discussed.
Deniz
Kemal
K
Department of Pathology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. kdeniz@erciyes.edu.tr
Tanriverdi
Fatih
F
Selçuklu
Ahmet
A
Kontaş
Olgun
O
Keleştimur
Fahrettin
F
D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002864:Chromogranins / Q000378:metabolism; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007247:Infertility, Female / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016708:Synaptophysin / Q000378:metabolism; D014786:Vision Disorders / Q000209:etiology
D006063:Chorionic Gonadotropin; D002864:Chromogranins; D005300:Fertility Agents, Female; D016708:Synaptophysin; D002996:Clomiphene