title: The clinical spectrum of cytomegalovirus colitis in adults.
abstract: BACKGROUND
  Colonic cytomegalovirus reactivation rarely occurs in adults without inflammatory bowel disease or a known immunosuppressive state.
  
  
  OBJECTIVE
  To describe our experience with such patients.
  
  
  METHODS
  All consecutive admissions of patients with possible cytomegalovirus colitis, between 1995 and 2006, were reviewed retrospectively.
  
  
  RESULTS
  Nineteen patients were studied. Most of the patients were elderly with multiple co-morbidities. Three main forms of disease presentation were recognized: acute diarrhoea, chronic diarrhoea and lower gastrointestinal bleeding. Colonic mucosal intranuclear inclusion bodies were found in 12 patients. Thirteen patients had cytomegalovirus viraemia (either by polymerase chain reaction and/or by white blood cell-cytomegalovirus antigenaemia test). Ganciclovir therapy was given to only eight patients; only five of these patients survived. The other subgroup of 11 patients received only supportive therapy. Most of the patients from this subgroup had a prolonged and complicated hospital course; only nine patients survived. Follow-up colonoscopies were performed only in five patients (out of the 14 patients who survived). In four of these patients, chronic mucosal inflammatory changes were noted.
  
  
  CONCLUSIONS
  Cytomegalovirus colitis occurs rarely in adult individuals. The disease may have various and multiple acute and/or chronic clinical manifestations. Clinical awareness of this condition is needed.
authors.affiliation: Department of Internal Medicine, Mount Scopus Campus, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Einbinder
authors.forename: D G
authors.initials: DG
authors.lastname: Wolf
authors.forename: O
authors.initials: O
authors.lastname: Pappo
authors.forename: A
authors.initials: A
authors.lastname: Migdal
authors.forename: E
authors.initials: E
authors.lastname: Tsvang
authors.forename: Z
authors.initials: Z
authors.lastname: Ackerman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000302:isolation & purification; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D003092:Colitis / Q000401:mortality / Q000503:physiopathology / Q000821:virology*; D003113:Colonoscopy; D015897:Comorbidity; D003587:Cytomegalovirus / Q000187:drug effects / Q000276:immunology / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D015774:Ganciclovir