title: Stereotactic radiosurgery for thoracic malignancies.
abstract: Radiosurgery for lung cancer is a novel and promising concept that warrants thorough review. Stereotactic body radiotherapy enables the selective delivery of an intense dose of high-energy radiation to destroy a tumor with precise targeting. The radiobiology and physics behind the use of radiosurgery are presented, followed by a discussion of promising retrospective and prospective clinical data that has been reported from Japan, Europe, and the United States. The article closes with a discussion of multidisciplinary approaches that include radiosurgery which are on the therapeutic horizon.
authors.affiliation: Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA. jamie.cesaretti@msnyuhealth.org
authors.forename: Jamie A
authors.initials: JA
authors.lastname: Cesaretti
authors.forename: Arjun
authors.initials: A
authors.lastname: Pennathur
authors.forename: Barry S
authors.initials: BS
authors.lastname: Rosenstein
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Swanson
authors.forename: Hiran C
authors.initials: HC
authors.lastname: Fernando
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D018579:Patient Selection; D011379:Prognosis; D016634:Radiosurgery / Q000379:methods*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013899:Thoracic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome