title: Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage.
abstract: OBJECTIVE
  To evaluate the therapeutic effect of alanyl-glutamine dipeptide (AGD) in the treatment of severe acute pancreatitis (SAP) in early and advanced stage.
  
  
  METHODS
  Eighty patients with SAP were randomized and received 100 mL/d of 20% AGD intravenously for 10 d starting either on the day of (early treatment group) or 5 d after (late treatment group) admission. Groups had similar demographics, underlying diseases, Ranson score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Balthazar's computed tomography (CT) score at the beginning of the study and underwent similar other medical and nutritional management.
  
  
  RESULTS
  The duration of acute respiratory distress syndrome (2.7 +/- 3.3 d vs 12.7 +/- 21.0 d, P < 0.01), renal failure (1.3 +/- 0.5 d vs 5.3 +/- 7.3 d, P < 0.01), acute hepatitis (3.2 +/- 2.3 d vs 7.0 +/- 7.1 d, P < 0.01), shock (1.7 +/- 0.4 d vs 4.8 +/- 3.1 d, P < 0.05), encephalopathy (2.3 +/- 1.9 d vs 9.5 +/- 11.0 d, P < 0.01) and enteroparalysis (2.2 +/- 1.4 d vs 3.5 +/- 2.2 d, P < 0.01) and hospital stay (28.8 +/- 9.4 d vs 45.2 +/- 27.1 d, P < 0.01) were shorter in the early treatment group than in the late treatment group. The 15-d APACHE II score was lower in the early treatment group than in the late treatment group (5.0 +/- 2.4 vs 8.6 +/- 3.6, P < 0.01). The infection rate (7.9% vs 26.3%, P < 0.05), operation rate (13.2% vs 34.2%, P < 0.05) and mortality (5.3% vs 21.1%, P < 0.05) in the early treatment group were lower than in the late treatment group.
  
  
  CONCLUSIONS
  Early treatment with AGD achieved a better clinical outcome in SAP patients.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Deng
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Zhao-Da
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Hu
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Song
authors.forename: Zong-Wen
authors.initials: ZW
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D004151:Dipeptides / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis
chemical_list: D004151:Dipeptides; C054122:alanylglutamine