title: 'Immunization' against airborne tuberculosis by an earlier primary response to a concurrent intravenous infection.
abstract: Tuberculosis in mice is a lung disease. Airborne infection of this host species with Mycobacterium tuberculosis (Mtb) resulted in 20 days of Mtb growth in the lungs before further growth was inhibited and the level of infection stabilized. Inhibition of Mtb growth was associated with the production of interferon-gamma (IFN-gamma)-producing T cells in the lymph nodes and spleen and with the progressive accumulation of these cells in the lungs. Production of IFN-gamma-producing T cells was not discernable until about day 15 of infection, presumably because Mtb did not disseminate from the lungs to the draining lymph nodes and spleen until after an approximate 10-day delay. By contrast, in mice infected via the intravenous (i.v.) route, the spleen became infected almost immediately, resulting in much earlier production of IFN-gamma-producing T cells and earlier control of spleen and lung infection. In mice infected concurrently via both routes, earlier generation of immunity to the i.v. infection resulted in earlier accumulation of IFN-gamma-producing T cells in the lungs and earlier control of lung infection that was initiated via the airborne route. This protection against airborne infection afforded by an earlier primary immune response is equivalent to that expressed by mice vaccinated with bacillus Calmette-Guérin or certain other vaccines.
authors.affiliation: Division of Life Sciences and Research Institute for Life Sciences, Kangwon National University, Chunchon, Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Jung
authors.forename: Ronald
authors.initials: R
authors.lastname: LaCourse
authors.forename: Lynn
authors.initials: L
authors.lastname: Ryan
authors.forename: Robert J
authors.initials: RJ
authors.lastname: North
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D007156:Immunologic Memory; D019570:Inhalation Exposure; D007275:Injections, Intravenous; D007371:Interferon-gamma / Q000096:biosynthesis; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000254:growth & development* / Q000276:immunology; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control* / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission
chemical_list: D000942:Antigens, Bacterial; D007371:Interferon-gamma