title: Fluorous "racemic" mixture synthesis: polysaccharide-based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds.
abstract: The proof of concept experiments of fluorous "racemic" mixture synthesis (FRMS) is shown using polysaccharide-based chiral stationary phases. The mixture of racemic O-benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide-based chiral HPLC columns (DAICEL CHIRALCEL and CHIRALPAK series).
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tonoi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Curran
authors.forename: Koichi
authors.initials: K
authors.lastname: Mikami
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005461:Fluorine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008333:Mandelic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*; D011134:Polysaccharides; D013237:Stereoisomerism
chemical_list: D008333:Mandelic Acids; D011134:Polysaccharides; D005461:Fluorine