E2F7 and E2F8 keep the E2F family in balance.
An article by Li and colleagues (in this issue of Developmental Cell) shows that the atypical E2Fs, E2F7 and E2F8, are critical for mouse development. One of the important functions of these family members stems from a negative feedback loop in which E2F7 and E2F8 limit the expression of E2F1 and prevent E2F1-dependent apoptosis.
Moon
Nam-Sung
NS
MGH Cancer Center, Charlestown, MA 02129, USA.
Dyson
Nicholas
N
D000818:Animals; D002470:Cell Survival / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000172:deficiency* / Q000502:physiology*; D050702:E2F7 Transcription Factor / Q000172:deficiency* / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D012097:Repressor Proteins / Q000502:physiology*
D004268:DNA-Binding Proteins; D050702:E2F7 Transcription Factor; C504722:E2F8 protein, mouse; C479901:E2f7 protein, mouse; D012097:Repressor Proteins