[New theories in molecular mechanisms of general anesthesia].
The controversy of the specific and non-specific theories of general anesthesia continues. Recently, non-specific theory began to have the persuasive power again. Molecular dynamics of target protein of the anesthesia and hydrophobic dehydration due to anesthetic binding to the protein have been drawing researcher's attention. Clarification of relation between the action site and the molecular dynamics modification of target protein has been an increasingly important problem. With these contexts, I believe that the research in anesthetic mechanisms will shift to a new paradigm.
Seto
Tomoyoshi
T
Department of Anesthesiology, Shiga University of Medical Science, Otsu.
Ozaki
Masayuki
M
Imai
Takashi
T
Taniguchi
Yoshihiro
Y
Nosaka
Shuichi
S
D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D008958:Models, Molecular; D018079:Receptors, GABA / Q000187:drug effects
D018681:Anesthetics, General; D018079:Receptors, GABA