Hypertrophic cranial pachymeningitis in a patient with Cogan's syndrome.
A 63-year-old man presented with chronic headache and bilateral hearing loss. A physical examination showed bilateral conjunctivitis. Circulating anti-Cogan peptide antibodies were detected by dot blot analysis. He was diagnosed as having Cogan's syndrome (CS). Steroid therapy led to dramatic improvement of his symptoms and abnormal laboratory findings. During a tapering course of steroid therapy, he suffered from headache. An ophthalmoscopic examination revealed papillary edema. Magnetic resonance imaging of the brain showed hypertrophic cranial pachymeningitis (HCP). After steroid pulse therapy, HCP was improved. To our knowledge, this is the first case of CS complicated with HCP.
Togashi
Masaru
M
Third Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, Akita 010-8543, Japan.
Komatsuda
Atsushi
A
Masai
Rie
R
Maki
Nobuki
N
Hatakeyama
Takashi
T
Wakui
Hideki
H
Sawada
Ken-ichi
K
D001327:Autoimmune Diseases / Q000150:complications*; D006261:Headache / Q000150:complications / Q000209:etiology / Q000276:immunology*; D006312:Hearing Loss, Bilateral / Q000150:complications / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000276:immunology*; D008875:Middle Aged; D013577:Syndrome