title: Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
abstract: OBJECTIVE
  To assess the expression of heparanase in the different stages leading to endometrial cancer.
  
  
  METHODS
  The 38 examined specimens included adenocarcinoma, hyperplasia, and normal endometrium specimens. Heparanase, estrogen, and progesterone receptor expressions were analyzed immunohistochemically and the intensity was scored.
  
  
  RESULTS
  Secretory normal endometrium and simple hyperplasia specimens expressed the lowest mean values of expression (1.00 and 0.63, respectively); the complex hyperplasia specimens and G2 endometrioid adenocarcinoma showed the highest values of expression (2.33 and 2.71, respectively). A linear trend (P=0.005) of heparanase expression was observed when comparing the normal endometrium and simple hyperplasia group with the complex hyperplasia+G1 carcinoma group and the G2+G3 carcinoma group. Evaluation of atrophic and inactive endometrium compared with papillary serous carcinomas yielded no significant differences. We found no significant correlation between heparanase expression and estrogen receptor or progesterone receptor expression.
  
  
  CONCLUSIONS
  Heparanase expression was tightly regulated in endometrial tumorigenesis.
authors.affiliation: Department of Obstetrics-Gynecology, Tel-Aviv Sourasky Medical Center, Sackler Faulty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Canaani
authors.forename: Neta
authors.initials: N
authors.lastname: Ilan
authors.forename: Stella
authors.initials: S
authors.lastname: Back
authors.forename: Guy
authors.initials: G
authors.lastname: Gutman
authors.forename: Israel
authors.initials: I
authors.lastname: Vlodavsky
authors.forename: Dan
authors.initials: D
authors.lastname: Grisaru
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004714:Endometrial Hyperplasia / Q000201:enzymology* / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D000099175:Heparanase
chemical_list: D005966:Glucuronidase; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000099175:Heparanase