title: [New theories in molecular mechanisms of general anesthesia].
abstract: The controversy of the specific and non-specific theories of general anesthesia continues. Recently, non-specific theory began to have the persuasive power again. Molecular dynamics of target protein of the anesthesia and hydrophobic dehydration due to anesthetic binding to the protein have been drawing researcher's attention. Clarification of relation between the action site and the molecular dynamics modification of target protein has been an increasingly important problem. With these contexts, I believe that the research in anesthetic mechanisms will shift to a new paradigm.
authors.affiliation: Department of Anesthesiology, Shiga University of Medical Science, Otsu.
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Seto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ozaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Imai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nosaka
mesh_terms: D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D008958:Models, Molecular; D018079:Receptors, GABA / Q000187:drug effects
chemical_list: D018681:Anesthetics, General; D018079:Receptors, GABA