Implication of possible therapies targeted for the tachykinergic system with the biology of neurokinin receptors and emerging related proteins.
The neurokinin (NK) receptor family has been proposed as targets for neural-related diseases. The experimental studies indicate that this family of receptors might also be targets for malignancies, both solid and hematological tumors. However, an understanding of the biology of other rmolecules with sequence similarity to NK receptors is required. Of significance is the HGFIN gene that shares structural homology with NK1. Through this homology, the HGFIN interacts with the high affinity ligand of NK1, substance P. This report discusses potential applications for targets against NK receptors, and the role of HGFIN in drug designs. This review is relevant for central and peripheral nervous system drug development, and also cancer drugs for breast and neuroblastoma. The potential for leukemia drugs and Patents are also discussed.
Rameshwar
Pranela
P
UMDNJ-New Jersey Medical School, MSB, 185 South Orange Ave, Newark, NJ 07103, USA. rameshwa@umdnj.edu
D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001943:Breast Neoplasms / Q000188:drug therapy; D006801:Humans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D010330:Patents as Topic; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D018039:Receptors, Tachykinin / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D015320:Tachykinins / Q000502:physiology*
C503042:GPNMB protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D018040:Receptors, Neurokinin-1; D018039:Receptors, Tachykinin; D015320:Tachykinins