[Induction of synthesis and activation of Penicillium commune alpha-L-rhamnosidase].
For the first time the influence of a number of synthetic porfirin and fluoren derivatives, coordinative germanium substances and surfactants on the biosynthesis and activity of Penicillium commune 266 alpha-L-rhamnosidase has been studied. It is shown that some of porfirin derivatives and coordinative germanium substances may be used as inducers of biosynthesis (143-430%) and also as stimulators of alpha-L-rhamnosidase activity (15-44%). It is more expedient to use biscitratgermanium acid in a complex with asparaginic acid (430%) or threonine (370%) as inducers of biosynthesis of enzyme. At the same time the use of porfirin derivatives, in particular meso-tetra(N-methyl-6-chinoline)porfirin tosilate or its manganese complex, is more efficient as stimulators (40%) of alpha-L-rhamnosidase activity. The utilization of such surfactants as tregaloso-, peptido- and rhamnolipids is not expedient. These compounds either do not influence or inhibit biosynthesis and activity of P. commune alpha-L-rhamnosidase. Only in concentration of 0.01% rhamnolipid increased the activity of enzyme by 7.5%.
Varbanets'
L D
LD
Rzaieva
O M
OM
Seĭfullina
I I
II
Martsynko
O E
OE
Piesarohlo
O H
OH
Filippova
T O
TO
Zhylyna
Z I
ZI
Ishkov
Iu V
IuV
Karpenko
O V
OV
Shul'ha
O M
OM
D002852:Chromatography, Ion Exchange; D005857:Germanium / Q000737:chemistry / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000096:biosynthesis* / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010407:Penicillium / Q000187:drug effects / Q000201:enzymology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology
D009942:Organometallic Compounds; D011166:Porphyrins; D013501:Surface-Active Agents; D005857:Germanium; D006026:Glycoside Hydrolases; C022525:alpha-L-rhamnosidase