Mutagenicity of water-soluble FePt nanoparticles in Ames test.
A mutagenicity test was conducted on water-soluble FePt nanoparticles capped with tetramethylammonium hydroxide in a bacterial reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537, and Escherichia coli strain WP2uvrA/pKM101, with and without metabolic activation by S9 mix in the preincubation method. Mutagenicity was weakly positive in the TA100 strain without S9 mix (maximum specific activity was 61.6 revertants/mg), but negative in other cases.
Maenosono
Shinya
S
Suzuki
Toshimasa
T
Saita
Soichiro
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D007501:Iron / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D053768:Metal Nanoparticles; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D009154:Mutation; D010984:Platinum / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D000644:Quaternary Ammonium Compounds / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D012995:Solubility; D014867:Water / Q000737:chemistry
D009153:Mutagens; D000644:Quaternary Ammonium Compounds; D014867:Water; D010984:Platinum; D007501:Iron; C027917:tetramethylammonium