title: Attenuation of diastolic heart failure and life-threatening ventricular tachyarrhythmia after peripheral blood stem cell transplantation combined with cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis.
abstract: A patient had multiple myeloma and associated cardiac amyloidosis, which caused diastolic dysfunction and recurrent ventricular fibrillation. After implantation of a cardioverter-defibrillator (ICD), the patient underwent autologous peripheral blood stem cell transplantation (PBSCT). The life-threatening arrhythmias, such as ventricular fibrillation, disappeared, and diastolic dysfunction assessed by quantitative gated single photon emission computed tomography and Doppler echocardiography improved 7 months later. This may be the first report to document improvement of both a lethal rhythm disorder and diastolic dysfunction by PBSCT following ICD implantation in a case of cardiac amyloidosis associated with multiple myeloma.
authors.affiliation: First Department ofInternal Medicine, Fukushima Medical University, Hikarigaoka 1,Fukushima 960-1295, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yaoita
authors.forename: Masumi
authors.initials: M
authors.lastname: Iwai-Takano
authors.forename: Kazuei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kazuko
authors.initials: K
authors.lastname: Akutsu
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Noji
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kamiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohtake
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D017147:Defibrillators, Implantable; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011859:Radiography; D013610:Tachycardia / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D013997:Time Factors; D014182:Transplantation, Autologous; D014463:Ultrasonography