Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate.
The pyran-containing fragments 1 and 2 of AM3 have been synthesized from the common pyran intermediate 3. Careful orchestration of the alcohol protecting groups was necessary to facilitate deprotection of alcohol functionality in the presence of the chemically sensitive polyene chain.
Hicks
Jacqueline D
JD
Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
Roush
William R
WR
D000438:Alcohols / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D000095722:Amphidinols
D000438:Alcohols; D000475:Alkenes; D011090:Polyenes; D011714:Pyrans; C438973:amphidinol 3; D000095722:Amphidinols