Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.
de Rocquigny
Hugues
H
Institut Gilbert Laustriat, Photophysique des interactions moléculaires, UMR 7175 CNRS, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.
Shvadchak
Volodymyr
V
Avilov
Sergiy
S
Dong
Chang Zhi
CZ
Dietrich
Ursula
U
Darlix
Jean-Luc
JL
Mély
Yves
Y
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D019590:Nucleocapsid Proteins / Q000737:chemistry / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D016335:Zinc Fingers / Q000187:drug effects
D019380:Anti-HIV Agents; D019590:Nucleocapsid Proteins