title: Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach.
abstract: Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.
authors.affiliation: Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Salvioli
authors.forename: Miriam
authors.initials: M
authors.lastname: Capri
authors.forename: Paolo
authors.initials: P
authors.lastname: Tieri
authors.forename: Jonathan
authors.initials: J
authors.lastname: Loroni
authors.forename: Cristiana
authors.initials: C
authors.lastname: Barbi
authors.forename: Laura
authors.initials: L
authors.lastname: Invidia
authors.forename: Serena
authors.initials: S
authors.lastname: Altilia
authors.forename: Aurelia
authors.initials: A
authors.lastname: Santoro
authors.forename: Chiara
authors.initials: C
authors.lastname: Pirazzini
authors.forename: Michela
authors.initials: M
authors.lastname: Pierini
authors.forename: Elena
authors.initials: E
authors.lastname: Bellavista
authors.forename: Lilia
authors.initials: L
authors.lastname: Alberghina
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D013997:Time Factors