title: Biofilms--a microbial life perspective: a critical review.
abstract: Microorganisms attach to surfaces, start multiplying, and develop biofilms. Biofilm-associated cells can be differentiated from their suspended counterparts by the generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and up- and downregulation of their specific genes. The attachment of microorganisms is a complex process regulated by diverse characteristics--growth medium, substratum, and cell surfaces. An established biofilm structure comprises microbial cells and EPS, has a defined architecture, and provides an optimal environment for the exchange of genetic material between cells. Cells may also communicate via quorum sensing, which may in turn affect biofilm processes such as detachment. Biofilms have great importance for public health because of their role in certain infectious diseases and their importance in a variety of device-related infections. Because many antibiotics are unable to eradicate dense biofilms, much work is required to devise ways to prevent their occurrence and clear them from the host. A greater understanding of biofilm processes should lead to novel, effective strategies for biofilm control and improvement in patient care and management.
authors.affiliation: Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar-470 003, (MP), India.
authors.forename: Anekant
authors.initials: A
authors.lastname: Jain
authors.forename: Yashwant
authors.initials: Y
authors.lastname: Gupta
authors.forename: Rahul
authors.initials: R
authors.lastname: Agrawal
authors.forename: Piush
authors.initials: P
authors.lastname: Khare
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Jain
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D018407:Bacterial Physiological Phenomena; D001431:Bacteriological Techniques; D018441:Biofilms / Q000254:growth & development*; D002450:Cell Communication / Q000502:physiology; D003141:Communicable Diseases / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004864:Equipment and Supplies / Q000382:microbiology; D005109:Extracellular Matrix / Q000502:physiology; D017053:Infection Control; D023421:Models, Animal; D011134:Polysaccharides / Q000502:physiology; D011634:Public Health
chemical_list: D011134:Polysaccharides