title: Hyperemesis gravidarum that requires hospitalization and the use of antiemetic drugs in relation to maternal body composition.
abstract: OBJECTIVE
  The purpose of this study was to assess whether maternal prepregnancy body mass index was associated with the use of antiemetic drugs in early pregnancy and/or with the occurrence of hyperemesis gravidarum.
  
  
  METHODS
  A retrospective, population-based, cohort study. Women who delivered singleton infants (n = 749,435) from 1995-2003 were evaluated concerning the use of antiemetic drugs in early pregnancy (data available from 1995). Women who delivered singleton infants (n = 942,894) from 1992-2001 were evaluated concerning hospitalization because of hyperemesis gravidarum (data available until 2001). Adjusted odds ratios were determined by Mantel-Haenszel technique and were used as estimates of relative risk (RR).
  
  
  RESULTS
  Underweight pregnant women were more likely to use antiemetic drugs (RR, 1.19; 95% CI, 1.14-1.24) and to become hospitalized for hyperemesis gravidarum (RR, 1.43; 95% CI, 1.33-1.54) compared with ideal weight women. Obese women were less likely to use antiemetic drugs (RR, 0.93; 95% CI, 0.89-0.97) and less likely to require hospitalization because of hyperemesis (RR, 0.90; 95% CI, 0.85-0.95) compared with women with an ideal body mass index.
  
  
  CONCLUSIONS
  The use of antiemetic drugs and the occurrence of hyperemesis gravidarum are related to maternal body composition.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Linköping, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Cedergren
authors.forename: Jan
authors.initials: J
authors.lastname: Brynhildsen
authors.forename: Ann
authors.initials: A
authors.lastname: Josefsson
authors.forename: Adam
authors.initials: A
authors.lastname: Sydsjö
authors.forename: Gunilla
authors.initials: G
authors.lastname: Sydsjö
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013548:Sweden
chemical_list: D000932:Antiemetics