[Uric acid, apo-E and apo-C3 correlation in normo- and hyperlipidemia].
OBJECTIVE
To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia.


METHODS
Serum lipids, apolipoprotein spectrum and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 58 with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb.


RESULTS
Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences by content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid levels and apo-E in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative.


CONCLUSIONS
Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apo-E and apo-C3. A rise of apo-C3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia.
Boĭko
E R
ER
Ovechkin
A O
AO
Kaneva
A M
AM
Potolitsyna
N N
NN
Boĭko
S G
SG
D000293:Adolescent; D000328:Adult; D000368:Aged; D053305:Apolipoprotein C-III / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D053305:Apolipoprotein C-III; D001057:Apolipoproteins E; D015415:Biomarkers; D014527:Uric Acid