title: Tracking myocardial deformation using phase contrast MR velocity fields: a stochastic approach.
abstract: The authors propose a new approach for tracking the deformation of the left-ventricular (LV) myocardium from two-dimensional (2-D) magnetic resonance (MR) phase contrast velocity fields. The use of phase contrast MR velocity data in cardiac motion problems has been introduced by others (N.J. Pelc et al., 1991) and shown to be potentially useful for tracking discrete tissue elements, and therefore, characterizing LV motion. However, the authors show here that these velocity data: 1) are extremely noisy near the LV borders; and 2) cannot alone be used to estimate the motion and the deformation of the entire myocardium due to noise in the velocity fields. In this new approach, the authors use the natural spatial constraints of the endocardial and epicardial contours, detected semiautomatically in each image frame, to help remove noisy velocity vectors at the LV contours. The information from both the boundaries and the phase contrast velocity data is then integrated into a deforming mesh that is placed over the myocardium at one time frame and then tracked over the entire cardiac cycle. The deformation is guided by a Kalman filter that provides a compromise between 1) believing the dense field velocity and the contour data when it is crisp and coherent in a local spatial and temporal sense and 2) employing a temporally smooth cyclic model of cardiac motion when contour and velocity data are not trustworthy. The Kalman filter is particularly well suited to this task as it produces an optimal estimate of the left ventricle's kinematics (in the sense that the error is statistically minimized) given incomplete and noise corrupted data, and given a basic dynamical model of the left ventricle. The method has been evaluated with simulated data; the average error between tracked nodes and theoretical position was 1.8% of the total path length. The algorithm has also been evaluated with phantom data; the average error was 4.4% of the total path length. The authors show that in their initial tests with phantoms that the new approach shows small, but concrete improvements over previous techniques that used primarily phase contrast velocity data alone. They feel that these improvements will be amplified greatly as they move to direct comparisons in in vivo and three-dimensional (3-D) datasets.
authors.affiliation: Dept. of Math. & Diagnostic Radiol., Yale Univ. Sch. of Med., New Haven, CT.
authors.forename: F G
authors.initials: FG
authors.lastname: Meyer
authors.forename: R T
authors.initials: RT
authors.lastname: Constable
authors.forename: A J
authors.initials: AJ
authors.lastname: Sinusas
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan