title: Prevalence of transfusion-transmitted Chagas Disease among multitransfused patients in Brazil.
abstract: BACKGROUND
  Blood transfusion has always been an important route for Chagas Disease (CD) transmission. The high prevalence of CD in Latin America and its lifelong asymptomatic clinical picture pose a threat for the safety of the blood supply. The outcome of measures designed to improve transfusion safety can be assessed by evaluating the prevalence of CD among multitransfused patients
  
  
  METHODS
  In order to assess the impact of CD control measures on the safety of the blood supply, an observational cross-sectional study was designed to determine the prevalence of CD in 351 highly transfused patients, in which vectorial transmission was excluded. This study compared patients that received transfusion products before (n = 230) and after (n = 121) 1997, when measures to control transfusion-transmitted CD were fully implemented in Brazil.
  
  
  RESULTS
  The study group consisted of 351 patients exposed to high numbers of blood products during their lifetime (median number of units transfused = 51, range 10-2086). A higher prevalence of transfusion-transmitted CD (1.30%) was observed among multitransfused patients that received their first transfusion before 1997, compared with no cases of transfusion-transmitted CD among multitransfused patients transfused after that year. The magnitude of the exposure to blood products was similar among both groups (mean number of units transfused per year of exposure = 25.00 +/- 26.46 and 23.99 +/- 30.58 respectively; P = 0.75, Mann-Whitney test).
  
  
  CONCLUSIONS
  Multiple initiatives aimed to control vector and parental transmission of CD can significantly decrease transfusion-transmitted CD in Brazil. Our data suggest that mandatory donor screening for CD represents the most important measure to interrupt transmission of CD by blood transfusions.
authors.affiliation: Hematology and Hemotherapy Center, State University of Campinas, Campinas - SP, Brazil. erich@unicamp.br
authors.forename: Erich V
authors.initials: EV
authors.lastname: De Paula
authors.forename: Neiva S L
authors.initials: NS
authors.lastname: Goncales
authors.forename: Serge
authors.initials: S
authors.lastname: Xueref
authors.forename: Marcelo
authors.initials: M
authors.lastname: Addas-Carvalho
authors.forename: Simone C O
authors.initials: SC
authors.lastname: Gilli
authors.forename: Rodrigo N
authors.initials: RN
authors.lastname: Angerami
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Goncales
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D014355:Chagas Disease / Q000097:blood / Q000453:epidemiology* / Q000635:transmission*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D018580:Mandatory Testing; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D065227:Transfusion Reaction