Soluble fragment of HER2/neu receptor in the serum of patients with breast cancer with different levels of this protein expression in the tumor.
Serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein (2+/3+ according to immunohistochemical analysis) was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands. The level of HER2/neu in the serum decreased after removal of the primary tumor in the majority of patients.
Kushlinskii
N E
NE
N. N. Blokhin National Oncological Research Center, Russian Academy of Medical Sciences, Moscow.
Shirokii
V P
VP
Gershtein
E S
ES
Yermilova
V D
VD
Chemeris
G Yu
GY
Letyagin
V P
VP
D001940:Breast / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D001941:Breast Diseases / Q000097:blood / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000097:blood*
D018719:Erb-b2 Receptor Tyrosine Kinases