Intravitreal triamcinolone for the treatment of diabetic macular edema.
Diabetic macular edema is one of the leading causes of visual loss in first world countries and the first cause in diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study showed a significant benefit in using focal laser photocoagulation for the treatment of macular edema, more specifically defined as clinically significant macular edema. Nevertheless, progressive visual loss is found in the 26% of patients with diabetic macular edema treated with photocoagulation. The failure of laser treatment and the destructive nature of the therapy has forced researchers to pursue new alternatives including vitrectomy with or without internal limiting membrane peels, the use of proteinkinase C inhibitors, intravitreal injections of antibodies that inhibit the vascular endothelial growth factor, somatostatin analog, or the intravitreal injection with corticosteroids. Triamcinolone acetonide is glucocoticosteroid with antiangiogenic and antiedematous properties. Publications evaluating the safety and efficacy of intravitreal injection of triamcinolone in the treatment of diabetic macular edema show varying outcomes with respect to the increases of visual acuity and decreases in foveal thickness. Despite this, intravitreal triamcinolone is a treatment that has evolved quickly and is considered increasingly useful.
Gómez-Ulla
Francisco
F
Ophthalmology Service, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. ciulla@usc.es
Marticorena
Joaquín
J
Alfaro
D Virgil
DV
Fernández
Maribel
M
Méndez
Elizabeth Rodríguez
ER
Rothen
Michelle
M
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000601:surgery; D006207:Half-Life; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D014221:Triamcinolone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014822:Vitreous Body
D000893:Anti-Inflammatory Agents; D014221:Triamcinolone