[Metabolic syndrome, its phenotypes, and insulin resistance by HOMA-IR].
The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR > was higher in individuals with the MS (2.8+/-1.6 vs. 1.8+/-1.4) (p < 0.001). HOMA-IR >or= 2.5 allied good specificity and sensitivity levels for the association of MS and IR. Hyperglycemia, hypertrigliceridemia, and abdominal obesity, the MS components best related to IR, were statistically associated with HOMA-IR > 2.5, but not hypertension neither low HDL-c. The demonstration that some of MS phenotypes or associated abnormalities were more predictive for IR could point out to the possibility of the use of the index as a marker of the presence of IR associated to MS.
Oliveira
Ernesto P de
EP
Faculdades de Farmácia, Universidade Federal da Bahia, Salvador, BA. epo@ufba.br
Lima
Maria das Dores A v
Md
Souza
Mirabeau Levi A de
ML
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D003430:Cross-Sectional Studies; D005260:Female; D038321:Glycemic Index; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010641:Phenotype; D012016:Reference Values; D012680:Sensitivity and Specificity; D017678:Sex Distribution
D001786:Blood Glucose