title: [Morpho-functional changes in hair during their renewal].
abstract: Hair follicles (HF) in human embryogenesis are derived and formed from fetal epidermis, and their development is completed by fetal month 6. Their number remains constant during the whole life. Mature HF is an individual structural and functional unit of the skin, which is characterized by high level of regeneration processes. Hair renewal is caused by HF cyclic changes. HF transformations include the complex, consisting of three phases: growth (anagen), regression (catagen) and quiescence (telogen). These changes collectively comprise HF cycle. Hair growth cycle activity depends on the interaction of different cell populations and includes the processes of proliferation, differentiation, migration, apoptosis etc. The realization of each stage is controlled by a specific set of regulatory mechanisms of different nature.
authors.forename: I V
authors.initials: IV
authors.lastname: Gorpinich
authors.forename: V I
authors.initials: VI
authors.lastname: Nozdrin
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D006197:Hair / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D018859:Hair Follicle / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D006801:Humans; D015398:Signal Transduction