title: Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis.
abstract: A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. elliot.frohman@utsouthwestern.edu
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Frohman
authors.forename: Fiona
authors.initials: F
authors.lastname: Costello
authors.forename: Olaf
authors.initials: O
authors.lastname: Stüve
authors.forename: Peter
authors.initials: P
authors.lastname: Calabresi
authors.forename: David H
authors.initials: DH
authors.lastname: Miller
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Hickman
authors.forename: Robert
authors.initials: R
authors.lastname: Sergott
authors.forename: Amy
authors.initials: A
authors.lastname: Conger
authors.forename: Amber
authors.initials: A
authors.lastname: Salter
authors.forename: Kimberly H
authors.initials: KH
authors.lastname: Krumwiede
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Frohman
authors.forename: Laura
authors.initials: L
authors.lastname: Balcer
authors.forename: Robert
authors.initials: R
authors.lastname: Zivadinov
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000473:pathology; D012025:Reflex, Pupillary / Q000502:physiology; D014795:Visual Pathways / Q000473:pathology* / Q000503:physiopathology