title: Sensitization to turnip rape and oilseed rape in children with atopic dermatitis: a case-control study.
abstract: Turnip rape and oilseed rape 2S albumins are new allergens in children with atopic dermatitis suspected for food allergy. We recently found that 11% (206/1887) of these children had a positive skin prick test to seeds of oilseed rape (Brassica napus) and/or turnip rape (Brassica rapa). In the present case-control study we examined how the children with atopic dermatitis sensitized to turnip rape and oilseed rape had been breast-fed and whether they had some common sensitization pattern to certain foods or pollens. A total of 64 children with atopic dermatitis and a positive skin prick test to turnip rape and/or oilseed rape (>or=5 mm) were examined. Sixty-four age- and sex-matched children with atopic dermatitis but negative skin prick tests to turnip rape and oilseed rape served as case controls. The turnip rape and/or oilseed rape sensitized children with atopic dermatitis had significantly more often positive skin prick tests reactions and IgE antibodies to various foods (cow's milk, egg, wheat, mustard; p < 0.01) and pollens (birch, timothy, mugwort; p < 0.01) than the control children. They had been exclusively breast-fed for a longer period (median 4 months; p < 0.05) and had more often associated asthma (36%) and allergic rhinitis (44%). Children with atopic dermatitis sensitized to oilseed rape and turnip rape had high frequency of associated sensitizations to all foods and pollens tested showing that oilseed plant sensitization affects especially atopic children who have been sensitized to multiple allergens.
authors.affiliation: Department of Dermatology, Tampere University Hospital and University of Tampere, Tampere, Finland. sanna.poikonen@uta.fi
authors.forename: Sanna
authors.initials: S
authors.lastname: Poikonen
authors.forename: Tuija J
authors.initials: TJ
authors.lastname: Puumalainen
authors.forename: Hannu
authors.initials: H
authors.lastname: Kautiainen
authors.forename: Timo
authors.initials: T
authors.lastname: Palosuo
authors.forename: Timo
authors.initials: T
authors.lastname: Reunala
authors.forename: Kristiina
authors.initials: K
authors.lastname: Turjanmaa
mesh_terms: D000818:Animals; D029688:Brassica napus / Q000009:adverse effects / Q000276:immunology*; D029741:Brassica rapa / Q000009:adverse effects / Q000276:immunology*; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D003888:Desensitization, Immunologic; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E