title: MIB-1, Bcl-2 and p53 in odontogenic myxomas of the jaws.
abstract: Odontogenic myxoma is a rare benign neoplasm occurring in the jaws. Microscopically, it is composed of spindle or stellate-shaped cells arranged in a mucinous matrix. In some cases (20%), odontogenic epithelial islands may be found. The Authors evaluated p53, MIB-1, and Bcl-2 expressed by the epithelial and stromal elements in 12 cases of odontogenic myxoma of the jaws. The cells of the odontogenic epithelium were positive for Bcl-2, p53 and MIB-1. The stromal cell showed a high positivity for MIB-1. Proliferation of both the epithelial and stromal components could be related to the growth of this odontogenic tumour.
authors.affiliation: Dental School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Iezzi
authors.forename: A
authors.initials: A
authors.lastname: Piattelli
authors.forename: C
authors.initials: C
authors.lastname: Rubini
authors.forename: L
authors.initials: L
authors.lastname: Artese
authors.forename: M
authors.initials: M
authors.lastname: Fioroni
authors.forename: F
authors.initials: F
authors.lastname: Carinci
mesh_terms: D000293:Adolescent; D000328:Adult; D019254:Genes, bcl-2 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008339:Mandibular Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009232:Myxoma / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D009808:Odontogenic Tumors / Q000235:genetics* / Q000473:pathology*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases