From individual Wnt pathways towards a Wnt signalling network.
Wnt proteins play important roles during vertebrate and invertebrate development. They obviously have the ability to activate different intracellular signalling pathways. Based on the characteristic intracellular mediators used, these are commonly described as the Wnt/beta-catenin, the Wnt/calcium and the Wnt/Jun N-terminal kinase pathways (also called planar cell polarity pathway). In the past, these different signalling events were mainly described as individual and independent signalling branches. Here, we discuss the possibility that Wnt proteins activate a complex intracellular signalling network rather than individual pathways and suggest a graph representation of this network. Furthermore, we discuss different ways of how to predict the specific outcome of an activation of this network in a particular cell type, which will require the use of mathematical models. We point out that the use of deterministic approaches via the application of differential equations is suitable to model only small aspects of the whole network and that more qualitative approaches are possibly a suitable starting point for the prediction of the global behaviour of such large protein interaction networks.
Kestler
Hans A
HA
Clinic for Internal Medicine I, Medical Centre Ulm University, Robert-Koch-Strasse 8, 89081 Ulm, Germany.
Kühl
Michael
M
D000818:Animals; D002118:Calcium / Q000378:metabolism; D051177:Catenins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D048788:Growth and Development / Q000502:physiology*; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*
D051177:Catenins; D051153:Wnt Proteins; D048670:MAP Kinase Kinase 4; D019204:GTP-Binding Proteins; D002118:Calcium