title: Duloxetine versus placebo for the treatment of women with stress predominant urinary incontinence in Taiwan: a double-blind, randomized, placebo-controlled trial.
abstract: BACKGROUND
  This manuscript compares the efficacy and safety of duloxetine with placebo in Taiwanese women with SUI.
  
  
  METHODS
  Taiwanese women with SUI were were randomly assigned to placebo (n = 61) or duloxetine 80 mg/day (n = 60) in this double-blind, 8-week, placebo-controlled study. Outcome variables included: incontinence episode frequency (IEF), Incontinence Quality of Life questionnaire (I-QOL) scores, and Patient Global Impression of Improvement rating (PGI-I).
  
  
  RESULTS
  Decrease in IEF was significantly greater in duloxetine-treated than placebo-treated women (69.98% vs 42.56%, P < .001). No treatment differences in I-QOL scores were significant. There were significant differences in PGI-I rating. Treatment-emergent adverse events (TEAEs) were experienced by more duloxetine-treated than placebo-treated women (80.0% vs 44.3%; P < .001). Discontinuations due to adverse events were significantly greater for duloxetine-treated than placebo-treated women (26.7% vs 6.6%; P = .003).
  
  
  CONCLUSIONS
  Data provide evidence for the safety and efficacy of duloxetine for the treatment for Taiwanese women with SUI.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier: NCT00475358.
authors.affiliation: Division of Urology, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. lintl@vghtpe.gov.tw
authors.forename: Alex Tong-Long
authors.initials: AT
authors.lastname: Lin
authors.forename: Mou-Jong
authors.initials: MJ
authors.lastname: Sun
authors.forename: Hui-Lung
authors.initials: HL
authors.lastname: Tai
authors.forename: Yao Chi
authors.initials: YC
authors.lastname: Chuang
authors.forename: Shih-Tsung
authors.initials: ST
authors.lastname: Huang
authors.forename: Nick
authors.initials: N
authors.lastname: Wang
authors.forename: Yan Daniel
authors.initials: YD
authors.lastname: Zhao
authors.forename: Julie
authors.initials: J
authors.lastname: Beyrer
authors.forename: Meghan
authors.initials: M
authors.lastname: Wulster-Radcliffe
authors.forename: Louise
authors.initials: L
authors.lastname: Levine
authors.forename: Curtis
authors.initials: C
authors.lastname: Chang
authors.forename: Lars
authors.initials: L
authors.lastname: Viktrup
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013624:Taiwan; D013876:Thiophenes / Q000627:therapeutic use*; D014550:Urinary Incontinence, Stress / Q000188:drug therapy*
chemical_list: D000068736:Duloxetine Hydrochloride; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes