Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease.
OBJECTIVE
Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor.


METHODS
For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters.


RESULTS
A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin.


CONCLUSIONS
This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.
Alamdari
Daryoush Hamidi
DH
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Ghayour-Mobarhan
Majid
M
Tavallaie
Shima
S
Parizadeh
Mohammad Reza
MR
Moohebati
Mohsen
M
Ghafoori
Fahimeh
F
Kazemi-Bajestani
Seyyed Mohammad Reza
SM
Paletas
Konstantinos
K
Pegiou
Theodosia
T
Koliakos
George
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*; D012307:Risk Factors
D000975:Antioxidants; D017382:Reactive Oxygen Species