Study of manganese bacteriopheophorbide as a potential contrast agent for magnetic resonance tomography.
The use of manganese bacteriopheophorbide characterized by a high relaxation capacity and selectively accumulating in the tumor as a contrast agent for magnetic resonance tomography significantly improves tumor contrasting against the background of normal tissues. The pharmacokinetics and selectivity of accumulation were studied by diffuse reflection spectroscopy.
Meerovich
I G
IG
N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow. meerovich@mail.ru
Brandis
A
A
Meerovich
G A
GA
Stratonnikov
A A
AA
Bendel
P
P
Oborotova
N A
NA
Shertz
A
A
Baryshnikov
A Yu
AY
D000818:Animals; D001429:Bacteriochlorophylls / Q000737:chemistry* / Q000493:pharmacokinetics; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D051379:Mice; D008819:Mice, Nude; D011877:Radionuclide Imaging
D001429:Bacteriochlorophylls; D003287:Contrast Media; D017895:Manganese Compounds