title: Orthopedic implant used as drug delivery system: clinical situation and state of the research.
abstract: A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part, an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation.
authors.affiliation: Laboratory of Biomechanical Orthopedics EPFL-HOSR, Institute of Translational Biomechanics, Ecole Polytechnique Fédérale Lausanne, Switzerland. dominique.pioletti@epfl.ch
authors.forename: Dominique P
authors.initials: DP
authors.lastname: Pioletti
authors.forename: Olivier
authors.initials: O
authors.lastname: Gauthier
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Stadelmann
authors.forename: Bruno
authors.initials: B
authors.lastname: Bujoli
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guicheux
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Zambelli
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bouler
mesh_terms: D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D004343:Drug Implants; D006801:Humans; D009983:Orthopedic Equipment; D009984:Orthopedic Fixation Devices; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D004343:Drug Implants