The selectins E and P in normal labour. A preliminary report on evaluation of their prognostic values for preeclampsia.
OBJECTIVE
Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour.


METHODS
The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 healthy, age-matched women at term). Blood samples were collected in the 1st, 2nd and 3rd stages of labour as well as two hours after placenta expulsion. The levels of soluble E- and P-selectins were measured by immunoenzymatic method (ELISA).


RESULTS
The levels of soluble E- and P-selectins in blood plasma of labouring women were within the similar medians and ranges during the 1st, 2nd and 3rd stages of labour as well as two hours after labour (p > 0.05).


CONCLUSIONS
The natural labour does not influence the level of soluble E-selectin and soluble P-selectin in blood plasma of labouring women, therefore the prognostic values of these markers of preeclampsia are preserved in the time of labour.
Uszyński
W
W
Regional Hospital in Włocławek, Poland.
Uszyński
M
M
Zekanowska
E
E
D000328:Adult; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010920:Placenta / Q000378:metabolism; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors
D019040:E-Selectin; D019007:P-Selectin