[Severe herpetic infection].
OBJECTIVE
To study antiviral defense in patients with severe anogenital and labial herpetic infection, prevalence of herpetic infection and possible combination with other strains.


METHODS
The immune status (basic lymphocyte subpopulations, IgA, IgM, IgG, circulating immune complexes in blood serum, cytokines, interferon status, functional activity of neutrophils) was investigated in 102 patients with severe Herpex simplex infection (HSI).


RESULTS
Marked deficiency and hyporeactivity of natural and/or specific cytotoxicity were found in 70% HSI patients with severe disease.


CONCLUSIONS
Severe HSI runs in serious combined secondary immunodeficiency, its complications and is an active mixed viral infection.
Didkovskiĭ
N A
NA
Malashnkova
I K
IK
Tanasova
A N
AN
Zuĭkov
I A
IA
Khitrik
N M
NM
Sarsaniia
Zh Sh
ZhSh
D000328:Adult; D005260:Female; D052776:Female Urogenital Diseases / Q000821:virology*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D052801:Male Urogenital Diseases / Q000821:virology*; D012002:Rectal Diseases / Q000821:virology; D012008:Recurrence
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007155:Immunologic Factors