Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice.
BACKGROUND
Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro.


METHODS
These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing human breast adenocarcinomas.


RESULTS
Vessel dilator, LANP, kaliuretic peptide and ANP eliminated 67%, 50%, 67% and 33% of the HTB-132 human breast adenocarcinomas. LANP eliminated 100% and vessel dilator 1/3 of CRL-2327 breast adenocarcinomas. There was no recurrence of the breast cancers in the primary site and no metastasis except in the ANP-treated group in one year post-treatment. The natriuretic peptide receptors-A and -C were decreased 50% and 31%, respectively, in metastatic versus primary ANP-treated breast adenocarcinomas.


CONCLUSIONS
Four cardiac hormones eliminate up to two-thirds of human breast adenocarcinomas in athymic mice.
Vesely
David L
DL
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA. david.vesely@med.va.gov
Vesely
Brian A
BA
Eichelbaum
Ehrentraud J
EJ
Sun
Ying
Y
Alli
Abdel A
AA
Gower
William R
WR
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D010446:Peptide Fragments / Q000627:therapeutic use; D011498:Protein Precursors / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010446:Peptide Fragments; D011498:Protein Precursors; C075322:atrial natriuretic factor precursor (79-98); C054548:atrial natriuretic factor prohormone (31-67); D009320:Atrial Natriuretic Factor