title: Synthesis and biological activity of chloroethyl pyrimidine nucleosides.
abstract: The synthesis and biological activity of chloroethyl pyrimidine nucleosides is presented. One of these new nucleosides analogues significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Limoges, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Colombeau
authors.forename: Karine
authors.initials: K
authors.lastname: Teste
authors.forename: Amel
authors.initials: A
authors.lastname: Hadj-Bouazza
authors.forename: Vincent
authors.initials: V
authors.lastname: Chaleix
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
authors.forename: Michel
authors.initials: M
authors.lastname: Kraemer
authors.forename: Odile Sainte
authors.initials: OS
authors.lastname: Catherine
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014846:Vulvar Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D006843:Hydrocarbons, Chlorinated; D011741:Pyrimidine Nucleosides