title: Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats.
abstract: In vitro studies have demonstrated that angiotensin II (ANG II) induces adipocyte hyperplasia and hypertrophy. The aim of the present study was to determine the effect of angiotensin-converting enzyme inhibition on body weight, adiposity and blood pressure in Sprague-Dawley rats. From birth half of the animals (n=15) were given water to drink, while the remainder were administered perindopril in their drinking water (2 mg/kg/day). Food intake, water intake and body weight were measured weekly. Blood pressure was measured by tail cuff plethysmography at 11-weeks. Body fat content and distribution were assessed using dual energy X-ray absorptiometry and Magnetic Resonance Imaging at 12 weeks. Animals administered with perindopril had a body fat proportion that was half that of controls. This was consistent with, but disproportionately greater than the observed differences in food intake and body weight. Perindopril treatment completely removed hypertension. We conclude that the chronic inhibition of ANG II synthesis from birth specifically reduces the development of adiposity in the rat.
authors.affiliation: School of Psychological Science, La Trobe University, Victoria 3086, Australia.
authors.forename: Harrison S
authors.initials: HS
authors.lastname: Weisinger
authors.forename: Denovan P
authors.initials: DP
authors.lastname: Begg
authors.forename: Gary F
authors.initials: GF
authors.lastname: Egan
authors.forename: Anura P
authors.initials: AP
authors.lastname: Jayasooriya
authors.forename: Fanny
authors.initials: F
authors.lastname: Lie
authors.forename: Michael L
authors.initials: ML
authors.lastname: Mathai
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Sinclair
authors.forename: John D
authors.initials: JD
authors.lastname: Wark
authors.forename: Richard S
authors.initials: RS
authors.lastname: Weisinger
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D020913:Perindopril / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D007703:Peptidyl-Dipeptidase A; D020913:Perindopril