Microalbuminuria is not associated with cisplatin-induced azotemia in dogs.
BACKGROUND
Cisplatin is an effective antineoplastic agent but its use is limited by renal toxicity. Microalbuminuria is a marker of renal damage and might be an indicator of cisplatin-induced azotemia.


OBJECTIVE
Microalbuminuria is not associated with azotemia in dogs treated with cisplatin.


METHODS
This study used 32 client-owned dogs.


METHODS
This was a prospective observational study in which cancer-bearing dogs were treated with cisplatin chemotherapy. Cisplatin-induced azotemia was defined as an increase of serum creatinine concentration above the reference range. Serum creatinine concentration, other routine tests of renal function, and microalbuminuria were measured after each cisplatin treatment. Variables potentially associated with azotemia were compared by use of Fisher's exact test and Wilcoxon's rank-sum test.


RESULTS
Cisplatin-induced azotemia occurred in 10 (31%) dogs after 1-5 treatments. At each of the first 3 treatments, the proportions of dogs with microalbuminuria were similar between dogs with and without azotemia.


CONCLUSIONS
Microalbuminuria measured after each treatment was not associated with azotemia through the first 3 treatments. Testing for microalbuminuria as a marker for cisplatin-induced renal damage is insensitive and not recommended.
Autio
Karoliina
K
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Rassnick
Kenneth M
KM
Goldstein
Richard E
RE
Erb
Hollis N
HN
D000419:Albuminuria / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D053099:Azotemia / Q000139:chemically induced / Q000662:veterinary*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary
D000970:Antineoplastic Agents; D002945:Cisplatin