title: Vacuum assisted closure device improves the take of mesh grafts in chronic leg ulcer patients.
abstract: BACKGROUND
  Vacuum assisted closure (VAC) is established in the management of acute and chronic wounds. In recent years, few data have been published concerning VAC therapy after skin graft transplantation.
  
  
  OBJECTIVE
  The aim of this study was to determine whether postoperative VAC helps assist closure of mesh grafts in chronic leg ulcer patients.
  
  
  METHODS
  We report a consecutive case series of 54 patients with chronic leg ulcers who received a total of 74 mesh grafts. A postoperative VAC therapy was performed in 28 mesh grafts, and 46 mesh grafts were treated with standard gauze therapy.
  
  
  RESULTS
  In the VAC group, 92.9% of grafts showed complete healing, compared to 67.4% in the control group without postoperative VAC therapy. Differential analysis revealed a negative correlation of the take rate in patients over 70 years of age or in patients suffering from diabetes mellitus or dermatoliposclerosis. Particularly patients with diabetes mellitus and of greater age exhibited improved take rates, both 100%, in the VAC group compared to 50 and 62%, respectively.
  
  
  CONCLUSIONS
  The results of our retrospective study demonstrate for the first time the significant benefit of VAC therapy after skin grafting in chronic leg ulcer patients as evaluated in a clinical trial.
authors.affiliation: Department of Dermatology, Essen University School of Medicine, Essen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Körber
authors.forename: T
authors.initials: T
authors.lastname: Franckson
authors.forename: S
authors.initials: S
authors.lastname: Grabbe
authors.forename: J
authors.initials: J
authors.lastname: Dissemond
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D048909:Diabetes Complications; D005260:Female; D006085:Graft Survival; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D012189:Retrospective Studies; D012307:Risk Factors; D016038:Skin Transplantation; D016896:Treatment Outcome; D014945:Wound Healing