title: Peripheral edema with hypoalbuminemia in a nonhuman primate infected with simian-human immunodeficiency virus: a case report.
abstract: A rhesus macaque (Macaca mulatta) infected with simian-human immunodeficiency virus (SHIV) while undergoing AIDS research, required a comprehensive physical examination when it presented with slight peripheral edema, hypoalbuminemia, and proteinuria. Many of the clinical findings were consistent with nephrotic syndrome, which is an indication of glomerular disease, but the possibility of concurrent disease needed to be considered because lentiviral induced immune deficiency disease manifests multiple clinical syndromes. The animal was euthanized when its condition deteriorated despite supportive care that included colloidal fluid therapy. Histopathology confirmed membranoproliferative glomerulonephritis, the result of immune complex deposition most likely due to chronic SHIV infection. Clinical symptoms associated with this histopathology in SHIV-infected macaques have not previously been described. Here we offer suggestions for the medical management of this condition, which entails inhibition of the renin-angiotensin-aldosterone system and diet modifications.
authors.affiliation: The Comparative Medicine Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA. clarke@mail.nih.gov
authors.forename: Carol L
authors.initials: CL
authors.lastname: Clarke
authors.forename: Michael A
authors.initials: MA
authors.lastname: Eckhaus
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Zerfas
authors.forename: William R
authors.initials: WR
authors.lastname: Elkins
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004274:DNA, Recombinant / Q000235:genetics; D004487:Edema / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1 / Q000502:physiology*; D034141:Hypoalbuminemia / Q000150:complications* / Q000188:drug therapy; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology; D008253:Macaca mulatta / Q000821:virology*; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*
chemical_list: D004274:DNA, Recombinant