Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa.
Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides ( 1 - 7), five flavonoids ( 8 - 12), one trimeric proanthocyanidin ( 13), two triterpenes ( 14 and 15), and one cerebroside ( 16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G ( 1 - 3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin ( 14), lupeol ( 15) and soyacerebroside I ( 16) demonstrated a potent tyrosinase inhibitory activity.
Magid
Abdulmagid Alabdul
AA
Laboratoire de Pharmacognosie, CNRS FRE 2715, IFR53 Biomolécules, Université de Reims Champagne-Ardenne, Reims, France.
Voutquenne-Nazabadioko
Laurence
L
Bontemps
Geoffroy
G
Litaudon
Marc
M
Lavaud
Catherine
C
D000363:Agaricales / Q000201:enzymology; D006801:Humans; D020128:Inhibitory Concentration 50; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D029631:Sapindaceae; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D010455:Peptides; D010936:Plant Extracts; D012717:Sesquiterpenes