title: Synthesis using aromatic homolytic substitution--recent advances.
abstract: This critical review aims at presenting recent developments in intramolecular aromatic homolytic substitution which has become one of the common methodologies in modern synthesis. The application of Bu3SnH-mediated cyclisations have proved especially useful. The critical review illustrates the mechanistic considerations required for planning synthetic applications and a wide range of synthetic protocols and natural product syntheses are shown. The latest evidence for the mechanisms involved in aromatic homolytic substitution are presented. (152 references).
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, Leicester, UK. w.r.bowman@lboro.ac.uk
authors.forename: W Russell
authors.initials: WR
authors.lastname: Bowman
authors.forename: John M D
authors.initials: JM
authors.lastname: Storey
mesh_terms: D003500:Cyclization; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005609:Free Radicals; D006841:Hydrocarbons, Aromatic