Combinatorial assembly of neurons: from chromatin to dendrites.
The generation and refinement of dendrites is essential for normal brain development and function. However, the molecular mechanisms that govern dendritic morphogenesis are poorly understood. Recent studies from the Crabtree laboratory have uncovered a requirement for the neuron-specific chromatin-remodeling enzyme nBAF in dendritic growth and branching in response to neuronal activity. These findings highlight the significance of epigenetic mechanisms in activity-dependent dendritic morphogenesis, with important implications in brain development and plasticity.
de la Torre-Ubieta
Luis
L
Department of Pathology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Bonni
Azad
A
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology; D002843:Chromatin / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003712:Dendrites / Q000235:genetics / Q000502:physiology*; D044127:Epigenesis, Genetic; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure
C467332:ACTL6B protein, human; D000199:Actins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins