Synthesis and cellular uptake of cell delivering 2,6-pyridinediylbisalkanamide submicron-sized sheets in hela cells.
2,6-Pyridinediylbisalkanamides were synthesized, using diaminopyridine (DAP) as a linker and alkyl chains of varying lengths, that upon self-assembly form submicron-sized sheets and their uptake into the cytoplasm of HeLa cells was studied by confocal microscopy.
Yadav
J S
JS
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. yadavpub@iict.res.in
Gupta
Manoj Kumar
MK
Prathap
I
I
Bhadra
Manika Pal
MP
Mohan
Parsi K
PK
Jagannadh
Bulusu
B
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D000631:Aminopyridines / Q000737:chemistry; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D006860:Hydrogen Bonding; D008567:Membranes, Artificial; D018613:Microscopy, Confocal; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties
D000577:Amides; D000631:Aminopyridines; D008567:Membranes, Artificial