Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors.
Dilks
J R
JR
Flaumenhaft
R
R
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D015703:Antigens, CD / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D005473:Fluoxetine / Q000494:pharmacology*; D006801:Humans; D008784:Methysergide / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D019007:P-Selectin / Q000097:blood; D010446:Peptide Fragments / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins; D044463:Receptor, PAR-1 / Q000819:agonists*; D044402:Receptor, Serotonin, 5-HT2A / Q000187:drug effects; D018048:Receptors, Purinergic P2 / Q000187:drug effects; D058472:Receptors, Purinergic P2Y1; D058925:Receptors, Purinergic P2Y12; D018179:Receptors, Thrombin / Q000819:agonists*; D012701:Serotonin / Q000097:blood; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D060149:Tetraspanin 30; D013917:Thrombin / Q000819:agonists / Q000494:pharmacology; D014631:Valerates / Q000494:pharmacology
D000225:Adenine; D015703:Antigens, CD; D005473:Fluoxetine; D008784:Methysergide; D009842:Oligopeptides; D019007:P-Selectin; D010446:Peptide Fragments; D010980:Platelet Membrane Glycoproteins; D044463:Receptor, PAR-1; D044402:Receptor, Serotonin, 5-HT2A; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1; D058925:Receptors, Purinergic P2Y12; D018179:Receptors, Thrombin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D060149:Tetraspanin 30; D013917:Thrombin; D014631:Valerates; C528918:2,2-dimethylpropionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethylpropionyloxymethyl)propyl ester; C554586:CD63 protein, human; C546382:P2RY1 protein, human; C548576:P2RY12 protein, human; C455901:alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine; C082835:thrombin receptor peptide (42-47); C112908:protease-activated receptor 4