Alarming dendritic cells for Th2 induction.
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
MacDonald
Andrew S
AS
the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK. andrew.macdonald@ed.ac.uk
Maizels
Rick M
RM
D000818:Animals; D001667:Binding, Competitive; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism*; D006801:Humans; D007107:Immune System; D008024:Ligands; D008954:Models, Biological; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism*
D016207:Cytokines; D008024:Ligands