title: Direct electrophilic monofluoromethylation.
abstract: Monofluoromethyl derivatives of various nucleophiles have been synthesized using a new electrophilic monofluoromethylating reagent developed. The S-(monofluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic monofluoromethyl group into C, S, O, N, and P nucleophiles. This methodology has been expanded for the synthesis of various biologically important compounds.
authors.affiliation: Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
authors.forename: Istvan
authors.initials: I
authors.lastname: Ledneczki
authors.forename: Sujith
authors.initials: S
authors.lastname: Chacko
authors.forename: George A
authors.initials: GA
authors.lastname: Olah
mesh_terms: D020650:Combinatorial Chemistry Techniques; D005459:Fluorides / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure
chemical_list: D005459:Fluorides