[Progression of gastric cancer observed for three and a half years under S-1 administration].
A 60-year-old male patient noticed a sudden epigastric pain and visited our hospital for treatment. Active gastric ulcer was discovered by a routine gastrointestinal endoscopy. Moderately differenciated tubular adenocarcinoma was confirmed by biopsy and was advised to take surgical treatment. However, he refused to go on with gastrectomy and selected to take S-1 as an oral anti-tumor drug instead. Despite many approaches to convince the patient to have surgery, three and a half years passed. Macroscopic findings have changed from 0-IIc type to infiltrating advanced type cancer. Finally, we persuaded him to take a surgical resection, but peritoneal dissemination was evident. Using S-1 against gastric cancer is common. However, S-1 should not be used before another evidence-based curative treatment is available. Furthermore, drugs should have been changed to others, if not effective. A rare clinical course is discussed.
Baba
Hiroyuki
H
Dept. of Surgery, Setagaya Shimoda General Hospital.
Suzuki
Kantaro
K
Sawada
Yuka
Y
Shimoda
Mahito
M
Shimoda
Shigeto
S
Nagahama
Takeshi
T
D018450:Disease Progression; D004338:Drug Combinations; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid