[Acquired ichthyosis revealing an Hodgkin's disease].
BACKGROUND
Acquired ichthyosis is a rare condition that usually reveals malignant diseases.


METHODS
A 70-year-old man was admitted with weight loss, diffuse ichthyosis, lymphadenopathy of the inguinal lymph nodes and elevated inflammatory markers in peripheral blood. Histology of the lymph node revealed mixed-cellularity Hodgkin disease. The evolution was fatal in spite of the chemotherapy.


CONCLUSIONS
Acquired ichthyosis is a cutaneous paraneoplastic syndrome, generally related to hematologic malignancies. A possible pathomecanism is the stimulation of epidermal growth secondary to the production of epidermal growth factor (EGF) by tumour cells. Acquired ichtyosis can rarely reveal systemic or infectious diseases. It can also be drug-induced or idiopathic.
Ennibi
K
K
Service de médecine interne, hôpital militaire d'instruction Mohammed-V, 10000 Rabat, Maroc. kennibi@yahoo.fr
Rabhi
M
M
Al Bouzidi
A
A
Bahrouch
L
L
Boudlal
M
M
Zinebi
A
A
Akhouad
Y
Y
Berady
S
S
Chaari
J
J
Toloune
F
F
D000368:Aged; D015415:Biomarkers / Q000097:blood; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007057:Ichthyosis / Q000209:etiology* / Q000473:pathology; D007249:Inflammation / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010257:Paraneoplastic Syndromes / Q000139:chemically induced / Q000473:pathology
D015415:Biomarkers