title: Combretastatin a-4 analogs as anticancer agents.
abstract: Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.
authors.affiliation: Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, U.P., India. anurag15182@rediffmail.com
authors.forename: Anurag
authors.initials: A
authors.lastname: Chaudhary
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.forename: P P
authors.initials: PP
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: N
authors.initials: N
authors.lastname: Soni
authors.forename: K K
authors.initials: KK
authors.lastname: Verma
authors.forename: G
authors.initials: G
authors.lastname: Bhardwaj
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; C058728:fosbretabulin