title: HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives.
abstract: The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak IA stationary phase.
authors.affiliation: Università La Sapienza, Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, 00185 Rome, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Biava
authors.forename: Roberto
authors.initials: R
authors.lastname: Cirilli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fares
authors.forename: Rosella
authors.initials: R
authors.lastname: Ferretti
authors.forename: Bruno
authors.initials: B
authors.lastname: Gallinella
authors.forename: Francesco
authors.initials: F
authors.lastname: La Torre
authors.forename: Giovanna
authors.initials: G
authors.lastname: Poce
authors.forename: Giulio Cesare
authors.initials: GC
authors.lastname: Porretta
authors.forename: Sibilla
authors.initials: S
authors.lastname: Supino
authors.forename: Claudio
authors.initials: C
authors.lastname: Villani
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles