title: IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population.
abstract: The regulatory IL-10 and TGF-beta1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-beta1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-beta1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan. edcampos@graduate.chiba-u.jp
authors.forename: Eduardo Jose
authors.initials: EJ
authors.lastname: Campos Alberto
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimojo
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Mashimo
authors.forename: Takayasu
authors.initials: T
authors.lastname: Arima
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsuura
authors.forename: Yuzaburo
authors.initials: Y
authors.lastname: Inoue
authors.forename: Akiko
authors.initials: A
authors.lastname: Yamaide
authors.forename: Minako
authors.initials: M
authors.lastname: Tomiita
authors.forename: Katsunori
authors.initials: K
authors.lastname: Fujii
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
mesh_terms: D000483:Alleles; D002648:Child; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D016753:Interleukin-10 / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1; D016753:Interleukin-10; D007073:Immunoglobulin E