[Biodegradable synthetic implant materials : clinical applications and immunological aspects].
In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.
Witte
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F
Labor für Biomechanik und Biomaterialien, Orthopädische Klinik der Medizinischen Hochschule Hannover, Anna-von-Borries-Str. 1-7, 30625, Hannover, Deutschland. frank.witte@annastift.de
Calliess
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T
Windhagen
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H
D020341:Absorbable Implants / Q000009:adverse effects*; D001860:Bone Plates / Q000009:adverse effects; D001863:Bone Screws / Q000009:adverse effects; D002130:Calcium Phosphates / Q000276:immunology; D002516:Ceramics / Q000009:adverse effects; D005593:Fracture Fixation, Internal; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D017616:Magnesium Compounds / Q000009:adverse effects; D008670:Metals / Q000009:adverse effects; D011108:Polymers / Q000009:adverse effects; D012307:Risk Factors
C022107:Bioglass; D002130:Calcium Phosphates; D017616:Magnesium Compounds; D008670:Metals; D011108:Polymers; C020243:calcium phosphate