title: Role of electrophysiologic study (EPS)-guided preventive therapy for the management of ventricular tachyarrhythmias in patients with heart failure.
abstract: BACKGROUND
  Ventricular tachyarrhythmias (VT/VF) are 1 of the most important factors determining the prognosis of patients with heart failure (HF). Although priority is given to implantable cardioverter defibrillator (ICD) therapy for the prevention of sudden cardiac death, electrophysiologic-study (EPS)-guided preventive therapy could be important for reducing the number of cardiac events.
  
  
  RESULTS
  Of 864 patients with a history of HF, an EPS was performed in 168 and 121 had inducible VT/VF. Under the basic therapy of an ICD, additional catheter ablation was attempted for 95 of 124 monomorphic VT foci in 74 patients, and 78 of the VT were successfully ablated. The prognoses were compared among 5 patient groups with different results for the EPS and catheter ablation: (1) success group (n=43), (2) failure group (n=15), (3) not attempted group (n=16), (4) VF group (n=47), and (5) no inducible VT/VF group. During a follow-up period of 31+/-22 months, the incidence of VT/VF was lower in the success and no inducible VT/VF groups than in the other groups (p=0.0018), although a significant difference was not observed for the total deaths.
  
  
  CONCLUSIONS
  EPS-guided preventive therapy using an ICD and catheter ablation can be useful, at least for the reduction of arrhythmic events in patients with HF.
authors.affiliation: Department of Cardio-angiology, Kitasato University School of Medicine, 1-15-1 Kitasato,Sagamihara 228-8555, Japan. shniwano@med.kitasato-u.ac.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Niwano
authors.forename: Hidehira
authors.initials: H
authors.lastname: Fukaya
authors.forename: Masaru
authors.initials: M
authors.lastname: Yuge
authors.forename: Ryuta
authors.initials: R
authors.lastname: Imaki
authors.forename: Shouji
authors.initials: S
authors.lastname: Hirasawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yumoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Inomata
authors.forename: Tohru
authors.initials: T
authors.lastname: Izumi
mesh_terms: D000368:Aged; D017115:Catheter Ablation; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000401:mortality / Q000503:physiopathology* / Q000517:prevention & control*