title: Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
abstract: The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.
authors.affiliation: Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
authors.forename: Soumyaditya
authors.initials: S
authors.lastname: Mula
authors.forename: Debashish
authors.initials: D
authors.lastname: Banerjee
authors.forename: Birija S
authors.initials: BS
authors.lastname: Patro
authors.forename: Sayanti
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Atanu
authors.initials: A
authors.lastname: Barik
authors.forename: Sandip K
authors.initials: SK
authors.lastname: Bandyopadhyay
authors.forename: Subrata
authors.initials: S
authors.lastname: Chattopadhyay
mesh_terms: D000818:Animals; D000975:Antioxidants; D015227:Lipid Peroxidation / Q000187:drug effects*; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D010100:Oxygen; D010636:Phenols / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000009:adverse effects*; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D010636:Phenols; D017319:Photosensitizing Agents; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D010100:Oxygen