title: Myocardial perfusion scintigraphy with adenosine: does it impair the left ventricular ejection fraction obtained with gated SPECT?
abstract: BACKGROUND
  The aim of this study was to assess whether adenosine impairs left ventricular ejection fraction (LVEF) obtained with gated SPECT in patients with a normal myocardial perfusion scintigram.
  
  
  METHODS
  This prospective study included 160 consecutive patients with a normal myocardial perfusion scintigraphy (MPS), who were stressed with either exercise (n = 64) or with adenosine (n = 96). Student t-test or chi test was used to compare patient's characteristics and functional parameters. Linear regression analyses were used to assess which patient characteristics had an independent significant influence on LVEF.
  
  
  RESULTS
  Functional parameters at rest were not significantly different between the adenosine group and the exercise stress group. However at stress, these functional parameters were significantly different. LVEF in the adenosine group decreased by -2.5%, whereas in the exercise group LVEF increased by 2.2% (P = 0.001). Moreover, in 36.5% of the patients a decrease in the LVEF of more than 5% was observed in the group stressed with adenosine compared with 15.6% in the exercise group (P = 0.002). In regression analysis, adenosine (P = 0.001) was selected as an independent significant correlate of a decrease in LVEF.
  
  
  CONCLUSIONS
  Adenosine seems to impair the LVEF obtained with gated SPECT in patients with a normal perfusion scintigram. Further evaluation is necessary to elucidate how adenosine exerts this effect and also, whether this finding has a prognostic value in patients with a normal perfusion scintigram.
authors.affiliation: Department of Nuclear Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Niels
authors.initials: N
authors.lastname: Brinkman
authors.forename: Petra
authors.initials: P
authors.lastname: Dibbets-Schneider
authors.forename: Arthur J H A
authors.initials: AJ
authors.lastname: Scholte
authors.forename: Marcel P M
authors.initials: MP
authors.lastname: Stokkel
mesh_terms: D000241:Adenosine; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D048909:Diabetes Complications / Q000000981:diagnostic imaging; D005080:Exercise Test; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
chemical_list: D000241:Adenosine