title: Atypical presentation of varicella-zoster virus encephalitis in an immunocompetent adult.
abstract: BACKGROUND
  Varicella-zoster virus encephalitis is uncommon, but not rare, in immunocompetent adults. Typically, patients develop stroke with hemiplegia caused by large vessel vasculopathy days to weeks after herpes zoster ophthalmicus.
  
  
  METHODS
  A previously healthy 66-year-old man developed obtundation deteriorating to coma within 24 hours. He had lymphocytic meningitis and multiple bilateral edematous and hemorrhagic lesions predominantly in the white matter, and intraventricular and subarachnoid hemorrhage. Treatment with acyclovir and dexamethasone was readily administered. The diagnosis of varicella-zoster virus encephalitis was confirmed by polymerase chain reaction analysis of the cerebrospinal fluid. No zosteriform rash preceded or followed encephalitis. Two years later, the patient is in good health, and no relapse or sign of immunosuppression has been reported.
  
  
  CONCLUSIONS
  This is a case of varicella-zoster virus encephalitis in an immunocompetent patient presenting without typical rash and with clinicoradiologic features of multifocal encephalitis, which characterize immunosuppression.
authors.affiliation: Intensive Care Unit, University of Thessaly, Larissa, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Mpaka
authors.forename: Apostolos H
authors.initials: AH
authors.lastname: Karantanas
authors.forename: Epaminondas
authors.initials: E
authors.lastname: Zakynthinos
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000368:Aged; D020804:Encephalitis, Varicella Zoster / Q000150:complications* / Q000276:immunology; D006429:Hemiplegia / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007121:Immunocompetence; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
chemical_list: D000212:Acyclovir