title: Effect of xylitol and fluoride on enamel erosion in vitro.
abstract: This study aimed to determine the anti-erosive effects of xylitol, fluoride and a xylitol/fluoride combination used as an additive in an acidic drink or as mouthrinse after enamel was exposed to an acidic drink, in vitro. Human third molars were divided into 7 groups (A-G). Samples from groups A to D were immersed for 5 min in orange juice only (A), orange juice plus either 25% xylitol (B), F(-) 1 ppm (C) or a 25% xylitol/F(-) 1 ppm combination (D), respectively. Samples from groups E to G were immersed in orange juice for 5 min and then in either 40% xylitol (E), F(-) 227 ppm (F) or a 40% xylitol/F(-) 227 ppm combination (G), for 1 min respectively. This process was performed four times daily for 14 days. Mineral loss was determined from the lesion depth and surface hardness. Erosion depth progressively increased in all groups, except E, where erosion depth was significantly lower than group A. Surface microhardness progressively decreased in all groups, except E, where hardness was significantly higher than group A. This study demonstrated that addition of xylitol, fluoride or a xylitol/fluoride combination to an acidic drink or post-treatment with fluoride or a xylitol/fluoride combination could reduce, but not prevent, enamel erosion.
authors.affiliation: Department of Prosthetic Dentistry, Faculty of Dentistry, Prince of Songkla University, Songkla, Thailand.
authors.forename: Siriwan
authors.initials: S
authors.lastname: Chunmuang
authors.forename: Suwanna
authors.initials: S
authors.lastname: Jitpukdeebodintra
authors.forename: Chanya
authors.initials: C
authors.lastname: Chuenarrom
authors.forename: Pojjanut
authors.initials: P
authors.lastname: Benjakul
mesh_terms: D001628:Beverages / Q000009:adverse effects; D002327:Cariostatic Agents / Q000627:therapeutic use*; D019343:Citric Acid / Q000009:adverse effects; D004338:Drug Combinations; D005459:Fluorides / Q000627:therapeutic use*; D005503:Food Additives; D006244:Hardness; D006801:Humans; D008964:Molar, Third; D009067:Mouthwashes / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000209:etiology; D014077:Tooth Erosion / Q000209:etiology / Q000517:prevention & control*; D014993:Xylitol / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D004338:Drug Combinations; D005503:Food Additives; D009067:Mouthwashes; D019343:Citric Acid; D005459:Fluorides; D014993:Xylitol