title: [Prenatal diagnostics in Arhus and Viborg Counties after implementation of first trimester risk assessment].
abstract: BACKGROUND
  In 2004 the Danish National Board of Health issued new guidelines for prenatal diagnostics in Denmark. The guidelines include a general offer to all pregnant women in Denmark of first trimester risk assessment of combined non-invasive tests integrating measurement of nuchal translucency and maternal biochemistry for detection of fetal chromosomal abnormalities like trisomy 21, and replacing the screening criteria of > or =35 of age.
  
  
  METHODS
  The study is based on registered data covering 5,504 pregnancies during the period 1 July 2005 to 31 December 2005 in Aarhus and Viborg Counties.
  
  
  RESULTS
  77% of the pregnant women had a complete combined test and only 2% declined the program. At a cut off at 1:400 at term the detection rate for trisomy 21 was 85% (CI: 62.1-96.8%) with a false positive rate of 3.4%. There was a significant reduction in the number of prenatal karyotypes from 2002 to 2005 in both counties, with a 58% reduction in Viborg County and 33% in Aarhus County. The percentage of abnormal karyotypes over the same period increased from 2.8%% to 11.4% in Viborg County, and from 7.1% to 15.4% in Aarhus County.
  
  
  CONCLUSIONS
  With a significant reduction in invasive procedures and a detection rate of 85% with a false positive rate of 3.4%, the results of the first trimester risk assessment program comply with the requirements defined by the Danish National Board of Health.
authors.affiliation: Arhus Universitetshospital, Skejby, Klinisk Biokemisk Afdeling, Arhus N. nto@ki.au.dk
authors.forename: Niels
authors.initials: N
authors.lastname: Tørring
authors.forename: Line Riis
authors.initials: LR
authors.lastname: Jølving
authors.forename: Olav Bennike Bjørn
authors.initials: OB
authors.lastname: Petersen
authors.forename: Anni
authors.initials: A
authors.lastname: Holmskov
authors.forename: Jens Michael
authors.initials: JM
authors.lastname: Hertz
authors.forename: Niels
authors.initials: N
authors.lastname: Uldbjerg
mesh_terms: D015415:Biomarkers / Q000097:blood; D025063:Chromosome Disorders / Q000175:diagnosis*; D003718:Denmark; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D007621:Karyotyping; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D015415:Biomarkers