title: Tracheo-broncho-bronchiolar lesions in Sjögren's syndrome.
abstract: A 53-year-old woman reported having a persistent cough and bloody sputum. She did not smoke but had received a diagnosis of Sjögren's syndrome. Chest CT revealed middle lobe syndrome, bronchiectasis and diffuse centrilobular nodular lesions. Bronchoscopy displayed multiple whitish polypoid lesions protruding from the cartilage rings and tracheobronchopathia osteochondroplastica was histologically confirmed by the presence of bony tissue in the tracheo-bronchial wall. Video-assisted thoracoscopic biopsy demonstrated lymphocyte aggregation causing follicular broncho-bronchiolitis. Erythromycin therapy resulted in improvement of the follicular bronchiolitis but not the tracheobronchopathia osteochondroplastica.
authors.affiliation: Division of Respiratory Medicine, National Defense Medical College, Namiki, Tokorozawa City, Saitama, Japan. kobahide@ndmc.ac.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kanoh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Motoyoshi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Aida
mesh_terms: D001982:Bronchial Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications*; D014133:Tracheal Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy