title: Increased levels of soluble syndecan-1 in the subretinal fluid and the vitreous of eyes with rhegmatogenous retinal detachment.
abstract: OBJECTIVE
  To investigate whether rhegmatogenous retinal detachment (RRD) alters intraocular soluble syndecan-1 levels.
  
  
  METHODS
  In all, 39 samples of subretinal fluid (SRF) and 10 samples of vitreous fluid from RRD patients were collected. Using ELISA, soluble syndecan-1 levels were detected, and potential correlations between syndecan-1 levels with clinical parameters were analyzed.
  
  
  RESULTS
  Soluble syndecan-1 in the vitreous fluid (2.577+/-0.578 ng/ml) and in the SRF (1.499+/-0.184 ng/ml) from eyes with RRD enhanced significantly compared to that of the controls (0.224+/-0.095 ng/ml) (p<0.0001 and p=0.006). An increase in the syndecan-1 concentrations in SRF samples correlated with a longer duration of retinal detachment (r=0.716, p<0.0001) and a younger age (r= -0.341, p=0.017).
  
  
  CONCLUSIONS
  RRD was found to be associated with a significant increase of soluble syndecan-1 in the vitreous fluid and SRF. In SRF, an enhanced soluble syndecan-1 concentration correlated positively with the duration of retinal detachment and inversely with the age of patients.
authors.affiliation: Department of Ophthalmology, Xijing Hospital, Xi'an, Shaanxi, China.
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Chao-Wei
authors.initials: CW
authors.lastname: Tian
authors.forename: Chang-Mei
authors.initials: CM
authors.lastname: Guo
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Du
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Liu
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Yan-Nian
authors.initials: YN
authors.lastname: Hui
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism*; D053668:Syndecan-1 / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: C508241:SDC1 protein, human; D053668:Syndecan-1