title: The termination of translation.
abstract: Recent results from cryoelectron microscopy, crystallography, and biochemical experiments have shed considerable light on the process by which protein synthesis is terminated when a stop codon is reached. However, a detailed understanding of the underlying mechanisms will require higher-resolution structures of the various states involved.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
authors.forename: Sabine
authors.initials: S
authors.lastname: Petry
authors.forename: Albert
authors.initials: A
authors.lastname: Weixlbaumer
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010443:Peptide Chain Termination, Translational; D010454:Peptide Termination Factors / Q000737:chemistry* / Q000378:metabolism; D012346:RNA, Transfer, Amino Acyl / Q000737:chemistry; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
chemical_list: D010454:Peptide Termination Factors; D012346:RNA, Transfer, Amino Acyl; D012269:Ribosomal Proteins; C087267:ribosome releasing factor; C019037:tRNA, peptidyl-