title: Efficient post-macrocyclization functionalizations of oxacalix[2]arene[2]pyrimidines.
abstract: Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind-Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Van Rossom
authors.forename: Wouter
authors.initials: W
authors.lastname: Maes
authors.forename: Lingam
authors.initials: L
authors.lastname: Kishore
authors.forename: Margriet
authors.initials: M
authors.lastname: Ovaere
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen