Peptoidic amino- and guanidinium-carrier systems: targeted drug delivery into the cell cytosol or the nucleus.
Efficient drug delivery is essential for many therapeutic applications. Some cell-penetrating peptides, peptide mimetics, and peptoids express transport function that, however, lack in most cases specific intracellular destination. In this study, carrier-peptoids with either amino or guanidinium side chains, were investigated with regard to their cellular uptake, toxicity, and intracellular localization. Transport specifically to the cytosol or to the nuclei was observed, thus providing a powerful tool for targeted drug delivery.
Schröder
Tina
T
University of Karlsruhe (TH), Institute of Organic Chemistry, Fritz-Haber-Weg 6, Karlsruhe, Germany. braese@ioc.uka.de
Niemeier
Nicole
N
Afonin
Sergii
S
Ulrich
Anne S
AS
Krug
Harald F
HF
Bräse
Stefan
S
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002470:Cell Survival; D003600:Cytosol / Q000378:metabolism*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
D000588:Amines; D004337:Drug Carriers; D006146:Guanidines; D034444:Peptoids