[Neuroadaptive changes in brain during selective serotonin reuptake inhibitors action].
Selective serotonin reuptake inhibitors such as fluoxetine that are widely used for the treatment of depression and anxiety disorders produce neuroadaptive change not only in the serotoninergic system but also in other neuromediator systems. These changes may be involved in the therapeutic as well as in side effects of the drugs.
Shishkina
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GT
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
D005473:Fluoxetine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors