Correction effect of ATP on platelet aggregation and blood coagulation in vitro and in the presence of circulating thrombin in rats.
ATP added to plasma samples in concentrations of 5x10(-3)-5x10(-5) M in vitro decreased ADP-induced platelet aggregation. Platelet aggregation stimulated with thrombin under similar experimental in vitro conditions significantly decreased in the presence of 5x10(-6) M ATP and tended to decrease under the influence of ATP in concentrations of 5x10(-3) and 5x10(-7)-5x10(-9) M ATP. When endogenous thrombin in the circulation was stimulated by intravenous infusion of tissue thromboplastin, pretreatment with ATP (4 intramuscular injections, 0.75 mg/kg) produced a correction effect and normalized disturbed anticoagulant activity and platelet aggregation.
Pastorova
V E
VE
Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University.
Lyapina
L A
LA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013917:Thrombin / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D013925:Thromboplastin / Q000494:pharmacology
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D013925:Thromboplastin; D013917:Thrombin