New insights into growth hormone receptor function and clinical implications.
Although used as a therapeutic for 50 years, it is only recently that the application of molecular techniques has provided a basis for understanding growth hormone's (GH) clinical actions. This article reviews progress in our current knowledge of the molecular mechanism of growth hormone (GH) receptor activation based on a number of physicochemical techniques, and documents insights gained into the means used by the activated GH receptor to control the expression of genes regulating growth and metabolism. These findings are related to disorders of short stature, and the therapeutic consequences are summarized.
Lichanska
A M
AM
School of Dentistry, University of Queensland, Brisbane, Australia.
Waters
M J
MJ
D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy; D005786:Gene Expression Regulation; D006130:Growth Disorders / Q000188:drug therapy*; D020249:Hormone Replacement Therapy; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D009765:Obesity / Q000188:drug therapy; D011986:Receptors, Somatotropin / Q000502:physiology* / Q000627:therapeutic use*; D050799:STAT5 Transcription Factor / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
D011986:Receptors, Somatotropin; D050799:STAT5 Transcription Factor