Comparison of behavioral effects of cortexin and cerebrolysin injected into brain ventricles.
We compared central effects of polypeptide preparations cortexin and cerebrolysin injected into brain ventricles of Wistar rats in doses of 1, 10, and 100 microg. Both drugs exhibited moderate psychoactivating effect, the effects cortexin were more pronounced compared to those of cerebrolysin in all tests.
Shabanov
P D
PD
Department of Pharmacology, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg. shabanov@mail.rcom.ru
Lebedev
A A
AA
Stetsenko
V P
VP
Lavrov
N V
NV
Markov
S V
SV
Vojeikov
I V
IV
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C006952:cerebrolysin; C056590:cortexin