A comparative study of aqueous and organic-based films and coatings of PEGylated rosin derivative.
Rosin was partially esterified with polyethylene glycol 400 and reacted with maleic-anhydride to form an ester-adduct derivative. Derivative and native rosin were characterized for physicochemical properties. Aqueous coating system of derivative was developed by ammonia neutralization method. Organic-based films were produced using acetone. Aqueous and organic-based films were comparatively evaluated. Derivative exhibited an excellent coat-forming ability on spherical-units. Aqueous-based film exhibited very high water vapor transmission rate, wettability, water uptake, and leaching at pH 6.8. A 20% w/w aqueous-based coat could sustain diclofenac sodium release for 8 h, whereas, 20% w/w organic-based coat released 20.11% of drug in 8 h. In conclusion, aqueous coating system of synthesized rosin derivative can be developed; however, aqueous-coats are less efficient to retard the drug release rate. Instead, the organic-based coatings can efficiently be used for sustained drug delivery.
Morkhade
Dinesh Mahadeorao
DM
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India. dmmorkhade@gmail.com
Nande
Vishwanath Sundar
VS
Barabde
Umesh Vinayak
UV
Kamble
Manish U
MU
Patil
Arun T
AT
Joshi
Siddheshwar B
SB
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008299:Maleic Anhydrides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D012995:Solubility
D003692:Delayed-Action Preparations; D008299:Maleic Anhydrides; D012116:Resins, Plant; D011092:Polyethylene Glycols; C013893:rosin