Biology-inspired synthesis of compound libraries.
Biologically active small molecules represent the basis for chemical biology applications in which small molecules are used as chemical tools to probe biological processes. In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).
Kaiser
M
M
Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, Dortmund, Germany.
Wetzel
S
S
Kumar
K
K
Waldmann
H
H
D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry / Q000145:classification; D017124:Conserved Sequence; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D040681:Structural Homology, Protein
D001688:Biological Products; D054852:Small Molecule Libraries