[A successful treatment with down-staging chemotherapy for sigmoid colon cancer with unresectable multiple liver and lung metastases].
A 63-year-old woman was diagnosed as having a sigmoid colon cancer with synchronous unresectable multiple liver and lung metastases. After sigmoidectomy, she was treated with S-1 combined with CPT-11 as a down-staging chemotherapy. After 3 courses of chemotherapy, the liver and lung metastases reduced in size as partial response. In March 2005, extended right hepatectomy combined with MHV resection was performed. She was treated with 2 courses of chemotherapy after hepatectomy, and furthermore she underwent left lung upper lobectomy. She has been alive without any signs of recurrence for 33 months from the initial surgery. Recently, a progression of the systemic chemotherapy for colorectal cancer has been a promising modality to improve a poor prognosis for unresectable multiple liver or extrahepatic metastases from advanced colorectal cancer.
Nomura
Satoru
S
Dept. of General Surgery, Graduate School of Medicine, Chiba University.
Yoshidome
Hiroyuki
H
Kimura
Fumio
F
Shimizu
Hiroaki
H
Ohtsuka
Masayuki
M
Kato
Atsushi
A
Yoshitomi
Hideyuki
H
Nozawa
Satoshi
S
Furukawa
Katsunori
K
Mitsuhashi
Noboru
N
Takeuchi
Dan
D
Suda
Kousuke
K
Takano
Shigetsugu
S
Miyazaki
Masaru
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary*; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009367:Neoplasm Staging; D012811:Sigmoid Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor