title: [A case of advanced gastric cancer with obstructive jaundice due to liver metastases successfully treated with chemotherapy].
abstract: We report a successful case of chemotherapy for primary far-advanced gastric cancer accompanied with poor general condition related to jaundice due to hepatic metastasis. A 54-year-old man, who had been admitted to another hospital in October 2006 with a complaint of tarry stool, was referred to our hospital. The result of detailed examination revealed an advanced gastric cancer, multiple lymph node metastases and jaundice (T-Bil 3.3 mg/dL) due to multiple hepatic metastases. The performance status (PS) was level 4. In parallel with a whole body control, a combined therapy with S-1 and CPT-11 was performed from October 27 as the first-line therapy. As a consequence of the first course, the jaundice disappeared. After the second course, the patient left the hospital. However, the patient was re-admitted to hospital in January 2007 by a reason of fever and a deterioration of PS. As exacerbation of cancerous peritonitis and the primary tumor were seen, a weekly paclitaxel therapy was performed as the second-line therapy. Two courses of treatment resulted in the disappearance of ascites and a reduction of hepatic/lymph node metastasis. PS was improved to level 0 as well. After these therapies, the patient was discharged from the hospital. As of June 2007, he continuously receives chemotherapy as an outpatient.
authors.affiliation: Dept. of Surgery, Sakai Municipal Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Tomono
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakata
authors.forename: Ryouta
authors.initials: R
authors.lastname: Ohshiro
authors.forename: Shunji
authors.initials: S
authors.lastname: Kamigaki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Takemoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujimi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohsata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tatsuta
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005773:Gastroscopy; D006801:Humans; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014057:Tomography, X-Ray Computed