title: Tissue development and RNA control: "HOW" is it coordinated?
abstract: The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. lgvolk@weizmann.ac.il
authors.forename: Talila
authors.initials: T
authors.lastname: Volk
authors.forename: David
authors.initials: D
authors.lastname: Israeli
authors.forename: Ronit
authors.initials: R
authors.lastname: Nir
authors.forename: Hila
authors.initials: H
authors.lastname: Toledano-Katchalski
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D010641:Phenotype; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D013710:Tendons / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C106296:how protein, Drosophila; D012313:RNA