title: [Efficacy of heptavalent pneumococcal conjugate vaccine in children with cochlear implant].
abstract: OBJECTIVE
  The aim is to analyze the efficacy of heptavalent conjugate vaccine against Streptococcus pneumoniae (VPn7) in children with cochlear implant, in relation with the eradication of nasopharyngeal carriers and the prevention of complications. Analysis of the antimicrobial resistance and sensitivity of the different pneumococci strains isolated in cochlear implant nasopharyngeal carriers and healthy non-vaccinated children.
  
  
  METHODS
  Pneumococcal nasopharyngeal carriers were analyzed in this prospective study including two groups of children aged between 2 and 5 years, from 2005 to 2006. The first group included 55 cochlear implant recipients and all of them were vaccinated with VPn7. The second group included 60 non-vaccinated healthy children. Nasopharyngeal swabs for culture were obtained from each child in order to detect the pneumococcus, its serotypes and the sensitivity to antibiotics.
  
  
  RESULTS
  In the control group of non-vaccinated children, 25% of them were found to be pharyngeal pneumococcus carriers, whereas this figure fell to 11% in the vaccinated group. The non-vaccine serotypes (83.3%) isolated in vaccinated children showed high or moderate sensitivity to penicillin. There were no complications due to S pneumoniae infections in any of the patients with cochlear implant who were vaccinated.
  
  
  CONCLUSIONS
  VPn7 contributes to a decrease in pharyngeal colonization by pneumococci in general and, in particular, by the pneumococcal serotypes included in the vaccine, although there is a replacement phenomenon involving non-vaccine serotypes.
authors.affiliation: Servicio de Microbiología, Complejo Hospitalario Universitario Insular Maternoinfantil de Gran Canaria, Universidad de Las Palmas, Las Palmas de Gran Canaria, Las Palmas, España. imigmar@gobiernodecanarias.org
authors.forename: Isabel
authors.initials: I
authors.lastname: de Miguel-Martínez
authors.forename: Angel
authors.initials: A
authors.lastname: Ramos-Macías
authors.forename: Silvia
authors.initials: S
authors.lastname: Borkoski Barreiro
mesh_terms: D002648:Child; D002675:Child, Preschool; D003054:Cochlear Implants / Q000382:microbiology*; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D009305:Nasopharynx / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000517:prevention & control*; D013296:Streptococcus pneumoniae
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines