title: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera.
abstract: Activity-guided fractionation of the methanol extract of Vitis vinifera bark led to the isolation of epsilon-viniferin, ampelopcin A, vitisin A and vitisin B. Vitisin A and vitisin B showed a remarkable inhibitory activity against 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase with IC50 value of 42.1 microM and 23.9 microM, respectively.
authors.affiliation: Korea Food Research Institute, Baekhyun-dong, Bundang-gu, Sungnam-si, Gyeonggi-do 463-746, South Korea. minsk@kfri.re.kr
authors.forename: M
authors.initials: M
authors.lastname: Koo
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: N
authors.initials: N
authors.lastname: Lee
authors.forename: M Y
authors.initials: MY
authors.lastname: Yoo
authors.forename: S Y
authors.initials: SY
authors.lastname: Ryu
authors.forename: D Y
authors.initials: DY
authors.lastname: Kwon
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000187:drug effects*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027843:Vitis
chemical_list: D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010936:Plant Extracts; D006903:Hydroxymethylglutaryl CoA Reductases