title: Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy.
abstract: BACKGROUND
  Post-anaesthetic shivering is one of the most common complications, occurring in 5-65% of patients recovering from general anaesthesia and 33% of patients receiving epidural anaesthesia. Our objective was to investigate the efficacy of intraoperative dexmedetomidine infusion on postoperative shivering.
  
  
  METHODS
  Ninety female patients, ASA I-II, 35-60 yr old, scheduled for elective total abdominal hysterectomy with or without bilateral salpingo-oophorectomy were randomized into two groups. After endotracheal intubation one group received normal saline infusion and the other received dexmedetomidine as a loading dose of 1 microg kg(-1) for 10 min followed by a maintenance infusion of 0.4 microg kg(-1) h(-1). In the recovery room, pain was assessed using a 100 mm visual analogue scale and those patients who had a pain score of more than 40 mm were administered 1 mg kg(-1) intramuscular diclofenac sodium. Patients with shivering grades more than 2 were administered 25 mg intravenous meperidine. Patients were protected with passive insulation covers.
  
  
  RESULTS
  Post-anaesthetic shivering was observed in 21 patients in the saline group and in seven patients in the dexmedetomidine group (P = 0.001). Shivering occurred more often in the saline group. The Ramsay Sedation Scores were higher in the dexmedetomidine group during the first postoperative hour. Pain scores were higher in the saline group for 30 min after the operation. The need for intraoperative atropine was higher in the dexmedetomidine group. Intraoperative fentanyl use was higher in the saline group. Perioperative tympanic temperatures were not different between the groups whereas postoperative measurements were lower in the dexmedetomidine group (P < 0.05).
  
  
  CONCLUSIONS
  Intraoperative dexmedetomidine infusion may be effective in the prevention of post-anaesthetic shivering.
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Sihhiye, Ankara, Turkey.
authors.forename: E G
authors.initials: EG
authors.lastname: Elvan
authors.forename: B
authors.initials: B
authors.lastname: Oç
authors.forename: S
authors.initials: S
authors.lastname: Uzun
authors.forename: E
authors.initials: E
authors.lastname: Karabulut
authors.forename: F
authors.initials: F
authors.lastname: Coşkun
authors.forename: U
authors.initials: U
authors.lastname: Aypar
mesh_terms: D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects*; D001831:Body Temperature / Q000187:drug effects; D020927:Dexmedetomidine / Q000008:administration & dosage*; D017558:Elective Surgical Procedures; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects* / Q000379:methods; D007262:Infusions, Intravenous; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control*; D012768:Shivering / Q000187:drug effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D020927:Dexmedetomidine; D005283:Fentanyl