Control of transcription in Schistosoma mansoni: chromatin remodeling and other regulatory elements.
The platyhelminth parasite Schistosoma mansoni, the causative agent of schistosomiasis, is a dioecious parasite with a complex life cycle that includes two different hosts and two free-living stages. Yet very little is known about the biochemical details connected to these different transitions. In the present work, results will be presented showing the most recent results in S. mansoni regarding the characterization of transcription factors and coactivators that act directly on the transcriptional machinery and those that are involved with chromatin remodeling. It is hoped that the information gathered here may contribute towards the understanding of crucial events in the parasite life cycle. Likewise, the development of new drugs that could interfere with oogenesis and sexual maturation may eventually profit from the information contained herein.
Fantappíé
Marcelo Rosado
MR
Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Cidade Universitária, CEP 21941-590, Rio de Janeiro, Brazil.
de Oliveira
Francisco M Bastos
FM
de Moraes Maciel dos Santos
Renata
R
Mansure
José João
JJ
Furtado
Daniel Rodrigues
DR
de Abreu da Silva
Isabel Caetano
IC
Rumjanek
Franklin David
FD
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D050436:Regulatory Elements, Transcriptional; D012550:Schistosoma mansoni / Q000502:physiology*