title: Antimicrobial prenylated dihydrochalcones from Eriosema glomerata.
abstract: Two new natural dihydrochalcones exhibiting antimicrobial properties together with six known compounds were isolated from the Cameroonian medicinal plant Eriosema glomerata. The structures of the new dihydrochalcones were elucidated as 2',4'-dihydroxy-4-methoxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone and 2',4'-dihydroxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone by detailed spectroscopic analysis. The two new dihydrochalcones, named erioschalcones A ( 1) and B ( 2), demonstrated significant inhibitory activity against the microbial strains Bacillus megaterium, Escherichia coli, Chlorella fusca and Microbotryum violaceum.
authors.affiliation: Department of Chemistry, University of Dschang, Dschang, Cameroon.
authors.forename: Maurice D
authors.initials: MD
authors.lastname: Awouafack
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Dieudonne
authors.initials: D
authors.lastname: Ngamga
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Green
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D047188:Chalcones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000460:Chlorophyta / Q000187:drug effects; D007887:Fabaceae; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D054876:Prenylation
chemical_list: D000890:Anti-Infective Agents; D047188:Chalcones; D010936:Plant Extracts; C015812:dihydrochalcone