Essential factors for successful virtual screening.
Virtual high-throughput screening (vHTS) is a powerful technique for identifying hit molecules as starting points for medicinal chemistry. Numerous successful applications of vHTS have been published using a large variety of methodologies. This review attempts to identify the essential factors for successful virtual screening in the hit identification phase.
Seifert
Markus H J
MH
4SC AG, Am Klopferspitz 19A, D-82152 Planegg-Martinsried, Germany. markus.seifert@4sc.com
Lang
Martin
M
D003198:Computer Simulation; D016208:Databases, Factual; D016503:Drug Delivery Systems; D015195:Drug Design; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship
D004364:Pharmaceutical Preparations