Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapy.
Mitochondrial research has influenced concepts in anthropology, human physiology and pathophysiology. We present here direct evidence that human recombinant viruses can localize in mitochondria to disrupt their integrity. This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution.
Alesci
Salvatore
S
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, Md., USA. alescis@wyeth.com
Abu-Asab
Mones
M
Perera
Shiromi M
SM
Tsokos
Maria
M
Morris
John C
JC
Pacak
Karel
K
D000257:Adenoviridae Infections / Q000235:genetics*; D000260:Adenoviruses, Human / Q000235:genetics* / Q000648:ultrastructure; D000818:Animals; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D004272:DNA, Mitochondrial / Q000235:genetics*; D003673:Defective Viruses / Q000235:genetics / Q000648:ultrastructure; D019143:Evolution, Molecular; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008928:Mitochondria / Q000235:genetics* / Q000648:ultrastructure / Q000821:virology*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000628:therapy; D011993:Recombinant Fusion Proteins / Q000235:genetics; D019444:Vaccines, DNA / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics
D004272:DNA, Mitochondrial; D011993:Recombinant Fusion Proteins; D019444:Vaccines, DNA