title: Synthesis and anticancer activity studies of cyclopamine derivatives.
abstract: A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine.
authors.affiliation: Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Massoud
authors.initials: M
authors.lastname: Garrossian
authors.forename: Dale
authors.initials: D
authors.lastname: Gardner
authors.forename: Arash
authors.initials: A
authors.lastname: Garrossian
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Cheng-Wei Tom
authors.initials: CW
authors.lastname: Chang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism; D013329:Structure-Activity Relationship; D014704:Veratrum Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002241:Carbohydrates; D053823:Hedgehog Proteins; D014704:Veratrum Alkaloids; C000541:cyclopamine