title: [Biological factors involved in the genesis of incisional hernia].
abstract: In the context of a surgically treated abdominal wall pathology, eventration of the wall, or incisional hernia, is one of the most prevalent complications. Despite numerous improvements over the years in suture materials and closure techniques, the incidence of incisional hernia has not diminished. Several general factors can influence the wound healing process after a laparotomy, but there are also biological factors that depend on the individual patient that can to a great extent explain the un-changing incidence of this pathology. Thus, different types of collagen, certain enzymes such as metalloproteinases and factors such as smoking have been attributed a role in the appearance of incisional hernia. These features suggest the need for a biomaterial to strengthen laparotomy closures, especially midline closures, in high-risk patients and/or in those where wound healing is compromised.
authors.affiliation: Departamento de Cirugía, Facultad de Medicina, Universidad de Alcalá, Madrid, España. juanm.bellon@uah.es
authors.forename: Juan M
authors.initials: JM
authors.lastname: Bellón
authors.forename: Hipólito J
authors.initials: HJ
authors.lastname: Durán
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D006555:Hernia, Ventral / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects* / Q000379:methods; D044342:Malnutrition / Q000150:complications; D045726:Metalloproteases / Q000378:metabolism; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000150:complications; D013536:Suture Techniques; D013537:Sutures; D013997:Time Factors; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D003094:Collagen; D045726:Metalloproteases