The role of genetics in Graves' disease and thyroid orbitopathy.
Graves' disease is a complex autoimmune disorder characterized by multiple systemic manifestations of overproduction of thyroid hormone, and in some cases, orbitopathy. The etiology of this disorder is multifactorial, involving heritable abnormalities of immune regulation as well as environmental triggers. The goal of this paper is to provide a review of recent research investigating candidate genes involved in the pathophysiology of both Graves' disease per se and of thyroid orbitopathy.
Kim
Nancy
N
Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA. Nancy-Kim@meei.harvard.edu
Hatton
Mark P
MP
D005819:Genetic Markers; D006111:Graves Disease / Q000235:genetics*; D049970:Graves Ophthalmopathy / Q000235:genetics*; D006801:Humans; D009916:Orbital Diseases / Q000235:genetics*
D005819:Genetic Markers