Cholestatic jaundice as the predominant presentation in a patient with autoimmune hepatitis.
Autoimmune hepatitis is a heterogeneous liver disease of unknown etiology. It is predominant in females and characterized by elevation of transaminase, hypergammaglobulinemia and circulating autoantibodies. Interface hepatitis and plasma cell infiltration are the main findings on liver biopsy. However, deep cholestatic jaundice is rarely seen. We present here an unusual case of type 1 autoimmune hepatitis with hyperbilirubinemia as the initial and predominant presentation. Although rare, autoimmune hepatitis should be considered in patients with cholestasis without history of drug or viral hepatitis.
Tang
Chia-Pei
CP
Division of Gastroenterology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Repblic of China.
Shiau
Yih-Tsong
YT
Huang
Yi-Hsiang
YH
Tsay
Shih-Haw
SH
Huo
Teh-Ia
TI
Wu
Jaw-Ching
JC
Lin
Han-Chieh
HC
Lee
Shou-Dong
SD
D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D041781:Jaundice, Obstructive / Q000209:etiology*; D008875:Middle Aged