title: Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
abstract: The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.
authors.affiliation: Institut Gilbert Laustriat, Photophysique des interactions moléculaires, UMR 7175 CNRS, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: de Rocquigny
authors.forename: Volodymyr
authors.initials: V
authors.lastname: Shvadchak
authors.forename: Sergiy
authors.initials: S
authors.lastname: Avilov
authors.forename: Chang Zhi
authors.initials: CZ
authors.lastname: Dong
authors.forename: Ursula
authors.initials: U
authors.lastname: Dietrich
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Darlix
authors.forename: Yves
authors.initials: Y
authors.lastname: Mély
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D019590:Nucleocapsid Proteins / Q000737:chemistry / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D016335:Zinc Fingers / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D019590:Nucleocapsid Proteins