Aromatic polyketides from marine algicolous fungi.
The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A ( 1) and (3 R)-7-hydroxy-5-methylmellein ( 2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements.
Pontius
Alexander
A
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
Mohamed
Ietidal
I
Krick
Anja
A
Kehraus
Stefan
S
König
Gabriele M
GM
D000164:Acremonium / Q000737:chemistry*; D001203:Ascomycota / Q000737:chemistry*; D001410:Bacillus megaterium / Q000187:drug effects; D002723:Chlorobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
C528144:(3R)-7-hydroxy-5-methylmellein; D002723:Chlorobenzoates; D049934:Isocoumarins; C528145:acremonisol A