title: Hybrid verrucous-squamous cell carcinoma of the ovary with synchronous squamous cell carcinoma of the endometrium.
abstract: Verrucous carcinoma, a variant of well-differentiated squamous cell carcinoma, is usually described in the literature as arising in the oral cavity, skin, and larynx. The reports on verrucous carcinoma arising in the genital tract, usually originating in the vagina, vulva, or uterine cervix, are few. Verrucous carcinoma arising in the ovary has not been previously reported. In this article, a unique hybrid carcinoma, a large aggressive verrucous carcinoma in combination with squamous carcinoma of the left ovary and synchronously occurring with a squamous cell carcinoma in the endometrium, is presented. This unique case of a hybrid carcinoma includes the first-known case of this type of carcinoma involving the ovary. The negative cervical evaluation findings, together with the histologic patterns of the tumors in the uterus and the ovary, support the conclusion that these 2 carcinomas are synchronous, one arising in the left ovary and the other arising in the uterus.
authors.affiliation: Department of Surgery, Saint Mary's Hospital, Waterburg, and University of Connecticut School of Medicine, CT 06706, USA.
authors.forename: Tiffany T
authors.initials: TT
authors.lastname: Fancher
authors.forename: Munir H
authors.initials: MH
authors.lastname: Hamzi
authors.forename: Shady H
authors.initials: SH
authors.lastname: Macaron
authors.forename: Winston B
authors.initials: WB
authors.lastname: Magno
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Dudrick
authors.forename: J Alexander
authors.initials: JA
authors.lastname: Palesty
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D018289:Carcinoma, Verrucous / Q000378:metabolism / Q000473:pathology*; D004238:Diverticulitis / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013617:Tachycardia, Supraventricular / Q000473:pathology