title: Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure.
abstract: BACKGROUND
  Combining phototherapy with topical vitamin D3 analogues is a useful therapy for the treatment of psoriasis by reducing the cumulative UV dose required for clearance of lesions. Experimental investigations demonstrated that calcipotriol is degraded by UV radiation, and suggested that calcipotriol should be applied after phototherapy but not immediately before.
  
  
  METHODS
  Calcipotriol or maxacalcitol ointment was topically applied to psoriatic plaques of six patients immediately before or after phototherapy on the right or left side of the body, respectively.
  
  
  RESULTS
  Topical application of vitamin D3 analogues either before or after irradiation by psoralen and UVA radiation (PUVA) or narrow-band (NB)-UVB showed exactly similar effects in all patients.
  
  
  CONCLUSIONS
  Therapeutic effects of vitamin D3 analogues are not clinically inactivated by subsequent irradiation with PUVA or NB-UVB phototherapy.
authors.affiliation: Department of Dermatology, Kanssai Medical University, Osaka, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Adachi
authors.forename: Naoko
authors.initials: N
authors.lastname: Uchida
authors.forename: Tomoo
authors.initials: T
authors.lastname: Matsuo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Horio
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives; D002762:Cholecalciferol / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014467:Ultraviolet Therapy
chemical_list: D003879:Dermatologic Agents; C055085:calcipotriene; D002762:Cholecalciferol; D002117:Calcitriol; C051883:maxacalcitol