title: Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies.
abstract: Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China. yycheng@mail.ustc.edu.cn
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
authors.forename: Mingzhong
authors.initials: M
authors.lastname: Li
authors.forename: Tongwen
authors.initials: T
authors.lastname: Xu
mesh_terms: D002166:Camptothecin / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry*; D012995:Solubility
chemical_list: D002214:Capsules; D050091:Dendrimers; D004337:Drug Carriers; C531249:Poly(amidoamine); D011073:Polyamines; D002166:Camptothecin