Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis.
The transglutaminase (Tgase) family consists of nine known members of whom at least three are expressed in the vascular system: type 1 Tgase, type 2 Tgase and factor XIII. The cross-linking of proteins is a characteristic feature of Tgases, of well-known importance for stabilizing the blood clot and providing mechanical strength to tissues. However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis.
Bakker
Erik N T P
EN
Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands. n.t.bakker@amc.uva.nl
Pistea
Adrian
A
VanBavel
Ed
E
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D001808:Blood Vessels / Q000254:growth & development / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D011503:Transglutaminases / Q000502:physiology*
D011503:Transglutaminases