Effect of Erabu sea snake (Laticauda semifasciata) lipids on the swimming endurance of aged mice.
The effect of Erabu sea snake (Laticauda semifasciata) lipids on the swimming endurance was investigated in aged mice. Fifty three-week-old male Crlj:CD-1 (ICR) mice were fed one of three experimental diets containing either 6% lard, 6% fish oil, or 6% sea snake lipids for 16 wk. The swimming exercise was carried out in an acrylic plastic tank filled with 25 cm of water maintained at 23(o)C. Swimming times to exhaustion were measured with a load of 2% of their body weights attached to the tails of the mice. The swimming times to exhaustion of the group that were fed the sea snake lipid diet tended to be longer than those of the lard diet group, and were significantly improved compared with the fish oil diet group (p<0.05). The plasma and muscle lactate levels were significantly lower in the sea snake lipid diet group than in the lard and fish oil diet groups (p<0.05). The liver glycogen and plasma glucose levels of the sea snake lipid diet group did not differ markedly from those of the lard diet group (p>0.05), and were significantly higher than those of the fish oil diet group (p<0.05). These results suggest that an intake of sea snake lipids but not the fish oil, which is also rich in n-3 polyunsaturated fatty acids (n-3 PUFAs), is useful for improving the swimming endurance of aged mice by attenuating lactate production and/or enhancing lactate clearance during swimming exercise, and the n-3 PUFAs contained in the sea snake lipids did little or nothing for this improved endurance.
Zhang
Guihua
G
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Shirai
Nobuya
N
Higuchi
Tomoyuki
T
Suzuki
Hiramitsu
H
Shimizu
Eiji
E
D000273:Adipose Tissue; D000375:Aging / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology*; D004435:Eating; D017815:Elapidae; D005395:Fish Oils / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000097:blood; D008099:Liver / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018482:Muscle, Skeletal / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010807:Physical Endurance / Q000187:drug effects*; D013550:Swimming / Q000502:physiology; D016474:Weight-Bearing
D004041:Dietary Fats; D005395:Fish Oils; D007773:Lactates; D006003:Glycogen; C029310:lard