Cell death in the IPLB-LdFB insect cell line: facts and implications.
The present review summarizes findings on stress-induced cell death in the IPLB-LdFB insect cell line derived from the larval fat body of the lepidopteron Lymantria dispar. Apoptotic, oncotic and autophagic cell death have been described in these cells as a consequence of oxidative stress or ATP deprivation, and similarities between IPLB-LdFB and mammalian apoptotic pathways have been highlighted. Furthermore, starting from observations in the IPLB-LdFB cells, a link has been surmised between relevance of autophagic cell death and developmental processes in the metazoan taxa.
Malagoli
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Department of Animal Biology, University of Modena and Reggio Emilia, Modena, Italy. davide.malagoli@unimore.it
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D016923:Cell Death; D002460:Cell Line; D007915:Lepidoptera / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
D000255:Adenosine Triphosphate