Fragile X syndrome with anxiety disorder and exceptional verbal intelligence.
Fragile X syndrome (FXS) is often characterized by mental retardation. However, FXS is also associated with significant emotional and psychiatric problems, including anxiety, depression, attention difficulties, and learning disabilities in the presence of a normal IQ. This report describes a unique woman with the full mutation of FXS who has an exceptional profile of above-average intelligence combined with significant impairments due to anxiety and learning disability. Women with FXS can present primarily with learning and emotional problems, and clinicians should consider FXS in these women regardless of their IQ.
Angkustsiri
Kathleen
K
M.I.N.D. Institute, University of California-Davis Medical Center, Sacramento, California 95817, USA. kathleen.angkustsiri@ucdmc.ucdavis.edu
Wirojanan
Juthamas
J
Deprey
Lesley J
LJ
Gane
Louise W
LW
Hagerman
Randi J
RJ
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014705:Verbal Behavior / Q000502:physiology*