Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.
Mula
Soumyaditya
S
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Banerjee
Debashish
D
Patro
Birija S
BS
Bhattacharya
Sayanti
S
Barik
Atanu
A
Bandyopadhyay
Sandip K
SK
Chattopadhyay
Subrata
S
D000818:Animals; D000975:Antioxidants; D015227:Lipid Peroxidation / Q000187:drug effects*; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D010100:Oxygen; D010636:Phenols / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000009:adverse effects*; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010636:Phenols; D017319:Photosensitizing Agents; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D010100:Oxygen