Heterogeneity of serum activities of matrix metalloproteinases in chronic endometritis.
Matrix metalloproteinases belong to the key molecules of tissue remodeling involved in physiological and pathological processes of the female reproductive system. Adequate levels of their expression in the endometrium are essential for effective implantation and uneventful pregnancy. Chronic inflammatory process in the endometrium is associated with low tissue expression of metalloproteinase-9. Histologically verified chronic endometritis is associated with low serum activities of metalloproteinases 2 and 9, which are restored after combined etiotropic therapy. We measured serum levels of metalloproteinases in patients with chronic endometritis concomitant with sterility and its changes during the first days after magnetotherapy.
Sukhikh
G T
GT
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Soboleva
G M
GM
Silantyeva
E S
ES
Shagerbieva
E A
EA
Serov
V N
VN
D000328:Adult; D002908:Chronic Disease; D004716:Endometritis / Q000097:blood* / Q000628:therapy; D005260:Female; D006801:Humans; D008280:Magnetics / Q000627:therapeutic use; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D020782:Matrix Metalloproteinases / Q000097:blood*; D026741:Physical Therapy Modalities
D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9