Role of cytokines and trophic factors in the pathogenesis of diabetic retinopathy.
Diabetic retinopathy (DR) is one of the most frequent complications of diabetes and the leading cause of acquired blindness in developed countries. A note worthy problem in DR is the formation of fibrovascular epiretinal membranes (ERMs) which can cause tractional retinal detachment in the progressed stage of DR. Ocular vitreous fluid and ERMs, which can be obtained during vitrectomy, allow laboratory studies investigating the pathogenesis of DR. Recent studies have shown a significant association between clinical grades of DR and the expression levels of specific cytokines, such as vascular endothelial growth factor (VEGF), in the intraocular fluid. In addition, expression of various trophic factors and their receptors are reported in ERMs. ERM is composed of many cell types including endothelial cells, which is the primary target of glucose-induced dysfunction in the retina. However, some trophic factor receptors are observed in other cell types such as the glial cells, and their role in ERMs is unclarified. These findings may uncover the detailed pathogenesis of DR, which may lead to new therapeutic strategies. This review briefly summarizes recent research regarding the clinical and laboratory findings of DR.
Mitamura
Yoshinori
Y
Department of Ophthalmology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Harada
Chikako
C
Harada
Takayuki
T
D018932:Chemokine CCL2 / Q000502:physiology; D016207:Cytokines / Q000502:physiology*; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000503:physiopathology*; D005451:Fluorescein Angiography; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D019746:Intramolecular Oxidoreductases / Q000502:physiology; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000502:physiology; D012160:Retina / Q000503:physiopathology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D008263:Macrophage Migration-Inhibitory Factors; D009414:Nerve Growth Factors; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human