title: Identification of hepatitis C virus subtype 2c by sequencing analysis in patients from Córdoba, Argentina.
abstract: In Argentina, most information on hepatitis C virus (HCV) genotype distribution comes from studies carried out in Buenos Aires (east province). In order to identify HCV subtypes in central Argentina, nucleotide sequencing of core region was performed in samples from 36 patients living in Córdoba, the second most populated province of Argentina. The sequence analysis identified subtype 2c as the most prevalent (50%), followed by subtype 1b (33%) and to a lesser extent by subtypes 1a (11%), 3a (3%) and 4a (3%). This is the first report of circulation of HCV subtype 2c in this region of Argentina and also such high prevalence has never been found before in the genotype distribution of South America.
authors.affiliation: Instituto de Virologia Dr. J M Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Viviana
authors.initials: V
authors.lastname: Ré
authors.forename: Marta
authors.initials: M
authors.lastname: Contigiani
authors.forename: Clara Fumiko Tachibana
authors.initials: CF
authors.lastname: Yoshida
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Lampe
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D001483:Base Sequence; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D014505:Urban Population
chemical_list: D020121:5' Untranslated Regions; D018937:Hepatitis C Antibodies; D012367:RNA, Viral