title: Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging.
abstract: The utility of perfusion-weighted magnetic resonance imaging (PW-MRI) for detecting changes in regional cerebral blood flow (rCBF) in patients with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) was evaluated. Thirteen cognitively normal (CN) elderly subjects, 35 mostly amnestic MCI subjects and 20 subjects with mild probable AD were enrolled. During i.v. injection of gadopentetate dimeglumine, a dynamic T2*-weighted single-shot EPI sequence was conducted using a 1.5-T scanner. Frontobasal (FROB), temporoparietal (TPAR), mesiotemporal (MTMP), anterior and posterior cingular (ACING, PCING), amygdala (AMYG), thalamus and cerebellar brain regions were studied. rCBF was computed from regional cerebral blood volume and arterial input function and normalised to white matter. Images were analysed by manually placed regions of interest using anatomical coregistration. Significant decreases of rCBF were detected in MCI vs. CN in MTMP (-23%), AMYG (-20%) and ACING (-15%) with no further decline in mild AD. In PCING hypoperfusion (-10%) was confined to AD. These hypoperfusional changes are a possible correlate of localised impairment of CNS function. In FROB no perfusion changes were observed between diagnostic groups, but hyperperfusion was observed in mild dementia stages, possibly reflecting functional compensatory mechanisms. These data suggest that PW-MRI detects specific changes in rCBF not only in AD, but also in amnestic MCI, a disorder suggested to largely represent a pre-dementia stage of AD. This method may thus be useful in both research and clinical applications to detect early functional brain changes in the pathogenesis of dementias.
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany. Electronic address: Christian.Luckhaus@lvr.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Luckhaus
authors.affiliation: Institute of Diagnostic Radiology, University Hospital, Duesseldorf, Germany.
authors.forename: Michael Oliver
authors.initials: MO
authors.lastname: Flüß
authors.affiliation: Institute of Diagnostic Radiology, University Hospital, Duesseldorf, Germany.
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Wittsack
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Grass-Kapanke
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Jänner
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany; Department of Psychiatry, Westfälische Klinik Dortmund, Germany.
authors.forename: Reza
authors.initials: R
authors.lastname: Khalili-Amiri
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Friedrich
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany.
authors.forename: Tillmann
authors.initials: T
authors.lastname: Supprian
authors.affiliation: Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D-40629, Duesseldorf, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gaebel
authors.affiliation: Institute of Diagnostic Radiology, University Hospital, Duesseldorf, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mödder
authors.affiliation: Institute of Diagnostic Radiology, University Hospital, Duesseldorf, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Cohnen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index