Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus.
A 44-year-old man with HES who developed a large thrombus in the right ventricle as well as multiple occlusive coronary thrombi died of cardiac failure. Autopsy showed that a large thrombus in the right ventricle was associated with eosinophilic endocarditis. In addition, an occlusive thrombus formed in the circumflex and right coronary arteries with eosinophilic infiltrate in the walls. The findings suggest a causal relationship between coronary thrombosis and eosinophilia. To the authors' knowledge this is the first report to document the clinical and histological findings of coronary thrombosis in a patient with HES.
Sato
Yuichiro
Y
Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. ysugar@fc.miyazaki-u.ac.jp
Fukunaga
Takashi
T
Hayashi
Tohru
T
Asada
Yujiro
Y
D000328:Adult; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000150:complications / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D006333:Heart Failure / Q000209:etiology / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use
D005938:Glucocorticoids; D011239:Prednisolone; D006918:Hydroxyurea