title: Choriocarcinoma with metastasis in a rabbit (Oryctolagus cuniculi).
abstract: A 3-year-old female rabbit (Oryctolagus cuniculi) presented with apathy and indisposition for 2-3 days. Palpation revealed a mass in the caudal abdomen, namely, in the wall of the uterus. Ovariohysterectomy was performed, and the tissues were submitted for histopathologic examination. The mass consisted of 3 different (trophoblastic, syncytiotrophoblastic, and cytotrophoblastic) neoplastic cell types originating from the uterus. Immunohistochemistry was positive for cytokeratin in all 3 neoplastic cell types, and the syncytiotrophoblasts were positive also for human chorionic gonadotropin. Together these features allow the diagnosis choriocarcinoma. This report documents the first case of a spontaneous choriocarcinoma in a rabbit.
authors.affiliation: Institute of Veterinary Pathology, Vetsuisse Faculty Zurich, Switzerland. mbart@access.unizh.ch
authors.forename: M
authors.initials: M
authors.lastname: Kaufmann-Bart
authors.forename: I
authors.initials: I
authors.lastname: Fischer
mesh_terms: D000818:Animals; D002822:Choriocarcinoma / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000662:veterinary*; D011817:Rabbits; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary*