[Lipid peroxidation and antioxidant systems in patients with HIV infection].
OBJECTIVE
To study lipid peroxidation (LPO) and anti-oxidant system (AOS) in patients with HIV infection.


METHODS
Enzymatic parameters of AOS and LPO were studied in 108 patients with HIV infection, 38 of them had HIV+HBV, HIV+HCV infection and 17 patients had associated tuberculosis.


RESULTS
Severe alterations of LPO were found: a significant rise of LPO products, malonic dialdehyde and dienic conjugates. LPO intensity depends on the disease stage, concomitant illnesses and treatment. LPO intensification in HIV-infected patients is accompanied with inhibition of total anti-oxidant activity of blood, catalase and superoxide dismutase. Low level of the latter evidences for failure of AOS at different periods of the disease. High LPO activity in HIV-infected patients may be one of pathogenetic mechanisms of the disease development and necessitates corrective therapy.


CONCLUSIONS
Assessment of LPO and AOS parameters can be used to control efficacy of the on-going treatment.
Nagoev
B S
BS
Sabanchieva
Zh Kh
ZhKh
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D002374:Catalase; D013482:Superoxide Dismutase