Comprehensive insight into human aminoacyl-tRNA synthetases as autoantigens in idiopathic inflammatory myopathies.
Autoantibodies against aminoacyl-tRNA synthetases (anti-AARS) belong to the group of the myositis specific autoantibodies (MSAs). Their association with the onset and development of the idiopathic inflammatory myopathies (IIM) implies their participation in the pathogenesis of the diseases. Since the appearing of anti-Jo-1 and other anti-AARSs is related to characteristic immunogenetic and clinical features, they can be considered specific markers in diagnosis and classification of patients affected by IIM. Here, we present an overview of anti-AARSs, their chemoattractant properties, their detection methods, genetic risks, and protective factors.
Jura
Miroslawa
M
Institute of Bioorganic Chemistry, Polish Academy of Sciences, 60-704 Poznan, Poland. mirka@bioinfo.pl
Rychlewski
Leszek
L
Barciszewski
Jan
J
D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006643:Histidine-tRNA Ligase / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D009220:Myositis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D001323:Autoantibodies; D001324:Autoantigens; D016207:Cytokines; D000604:Amino Acyl-tRNA Synthetases; D006643:Histidine-tRNA Ligase