title: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression.
abstract: The clinical efficacy of a systemically administered drug acting on the central nervous system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1). Here we report that polymorphisms in the ABCB1 gene predict the response to antidepressant treatment in those depressed patients receiving drugs that have been identified as substrates of ABCB1 using abcb1ab double-knockout mice. Our results indicate that the combined consideration of both the medication's capacity to act as an ABCB1-transporter substrate and the patient's ABCB1 genotype are strong predictors for achieving a remission. This finding can be viewed as a further step into personalized antidepressant treatment.
authors.affiliation: Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804 Munich, Germany. uhr@mpipsykl.mpg.de
authors.forename: Manfred
authors.initials: M
authors.lastname: Uhr
authors.forename: Alina
authors.initials: A
authors.lastname: Tontsch
authors.forename: Christian
authors.initials: C
authors.lastname: Namendorf
authors.forename: Stephan
authors.initials: S
authors.lastname: Ripke
authors.forename: Susanne
authors.initials: S
authors.lastname: Lucae
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Tatjana
authors.initials: T
authors.lastname: Dose
authors.forename: Martin
authors.initials: M
authors.lastname: Ebinger
authors.forename: Marcus
authors.initials: M
authors.lastname: Rosenhagen
authors.forename: Martin
authors.initials: M
authors.lastname: Kohli
authors.forename: Stefan
authors.initials: S
authors.lastname: Kloiber
authors.forename: Daria
authors.initials: D
authors.lastname: Salyakina
authors.forename: Thomas
authors.initials: T
authors.lastname: Bettecken
authors.forename: Michael
authors.initials: M
authors.lastname: Specht
authors.forename: Benno
authors.initials: B
authors.lastname: Pütz
authors.forename: Elisabeth B
authors.initials: EB
authors.lastname: Binder
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D000928:Antidepressive Agents; C507084:Abcb1b protein, mouse