[Prognostic significance of assay of sex hormones, their receptors and enzymes involved in estrogen synthesis and metabolism in endometrial carcinoma].
Prognostic significance of sex hormones, sex hormone-binding globulin, estrogen and progesterone receptors as well as the activity of enzymes involved in estrogen synthesis (aromatase, steroid sulfatase, estrogen hydroxylase, catechol-O-methyl transferase, glutathione-S-transferase) were investigated in 74 endometrial carcinoma patients. Stage and duration of uterine myoma history appeared to be significant factors of overall survival. Such factors as stage, depth of myometrial invasion, body mass, blood-serum estradiol level as well as aromatase and catechol-O-methyl transferase concentration in tumor tissue were significant for free-relapse free survival period.
Bochkareva
N V
NV
Kondakova
I V
IV
Kolomiets
L A
LA
Muntian
A B
AB
Stukanov
S L
SL
Fomina
S V
SV
D001141:Aromatase / Q000378:metabolism*; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D045166:Estradiol Congeners / Q000378:metabolism*; D004967:Estrogens / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D015996:Survival Rate
D045166:Estradiol Congeners; D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012738:Sex Hormone-Binding Globulin; D001141:Aromatase; D002394:Catechol O-Methyltransferase