The MCM helicase: linking checkpoints to the replication fork.
The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint. Interactions between MCM proteins, checkpoint kinases, and repair and recovery proteins suggest that MCMs are proximal effectors of replication fork stability in the cell and are likely to play an important role in maintaining genome integrity.
Forsburg
Susan L
SL
Molecular and Computational Biology Section, University of Southern California, 1050 Childs Way MCB 201B, Los Angeles, CA 90089-2910, USA. forsburg@usc.edu
D018797:Cell Cycle Proteins / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D012568:Schizosaccharomyces / Q000201:enzymology
D018797:Cell Cycle Proteins; D004265:DNA Helicases