title: Course of preeclamptic glomerular injury after delivery.
abstract: We evaluated the early postpartum recovery of glomerular function over 4 wk in 57 women with preeclampsia. We used physiological techniques to measure glomerular filtration rate (GFR), renal plasma flow, and oncotic pressure (pi(A)) and computed a value for the two-kidney ultrafiltration coefficient (K(f)). Compared with healthy, postpartum controls, GFR was depressed by 40% on postpartum day 1, but by only 19% and 8% in the second and fourth postpartum weeks, respectively. Hypofiltration was attributable solely to depression, at corresponding postpartum times, of K(f) by 55%, 30%, and 18%, respectively. Improvement in glomerular filtration capacity was accompanied by recovery of hypertension to near-normal levels and significant improvement in albuminuria. We conclude that the functional manifestations of the glomerular endothelial injury of preeclampsia largely resolve within the first postpartum month.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. michelle.hladunewich@sunnybrook.ca
authors.forename: M A
authors.initials: MA
authors.lastname: Hladunewich
authors.forename: B D
authors.initials: BD
authors.lastname: Myers
authors.forename: G C
authors.initials: GC
authors.lastname: Derby
authors.forename: K L
authors.initials: KL
authors.lastname: Blouch
authors.forename: M L
authors.initials: ML
authors.lastname: Druzin
authors.forename: W M
authors.initials: WM
authors.lastname: Deen
authors.forename: D M
authors.initials: DM
authors.lastname: Naimark
authors.forename: R A
authors.initials: RA
authors.lastname: Lafayette
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008954:Models, Biological; D049590:Postpartum Period / Q000502:physiology; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy