title: Sublingual administration of tacrolimus in a renal transplant patient.
abstract: Tacrolimus is used in renal and other organ transplantations for immunossupression therapy. Bioavailability of enterally administered tacrolimus is poor, and further reduced by gastrointestinal failure or enteral nutrition. In these situations, intravenous administration is necessary to prevent treatment failure. However, intravenous administration should be done in a continuous manner and it has been implicated in anaphylaxis, torsades de pointes, cardiac arrhythmia and other serious adverse events. Also it is more expensive than other routes of administration. Sublingual administration of tacrolimus has been used in some cases, and literature reports show that it provides therapeutic tacrolimus levels in lung and liver transplant recipients. Here, we report a first case of sublingual administration of tacrolimus in kidney transplantation.
authors.affiliation: Clinical Pharmacology Department, Hospital Universitario La Paz, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. ivan.romero@uam.es
authors.forename: I
authors.initials: I
authors.lastname: Romero
authors.forename: C
authors.initials: C
authors.lastname: Jiménez
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: F
authors.initials: F
authors.lastname: Escuin
authors.forename: E
authors.initials: E
authors.lastname: Ramirez
authors.forename: S
authors.initials: S
authors.lastname: Fudio
authors.forename: A
authors.initials: A
authors.lastname: Borobia
authors.forename: A
authors.initials: A
authors.lastname: Carcas
mesh_terms: D000286:Administration, Sublingual; D001682:Biological Availability; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D016030:Kidney Transplantation; D008875:Middle Aged; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus