title: On the mechanical properties of bovine serum albumin (BSA) adhesives.
abstract: Biological adhesives, natural and synthetic, are of current active interest. These adhesives offer significant advantages over traditional sealant techniques, in particular, they are easier to use, and can play an integral part in the healing mechanism of tissue. Thus, biological adhesives can play a major role in medical applications if they possess adequate mechanical behavior and stability over time. In this work, we report on the method of preparation of bovine serum albumin (BSA) into a biological adhesive. We present quantitative measurements that show the effect of BSA concentration and cross-linker content on the bonding strength of BSA adhesive to wood. A comparison is then made with synthetic poly(glycidyl methacrylate) (PGMA) adhesive, and a commercial cyanoacrylate glue, which was used as a control adhesive. In addition, BSA samples were prepared and characterized for their water content, tensile strength, and elasticity. We show that on dry surface, BSA adhesive exhibits a high bonding strength that is comparable with non-biological commercial cyanoacrylate glues, and synthetic PGMA adhesive. Tensile testing on wet wood showed a slight increase in the bonding strength of BSA adhesive, a considerable decrease in the bonding strength of cyanoacrylate glue, and negligible adhesion of PGMA. Tests performed on BSA samples demonstrate that initial BSA concentration and final water content have a significant effect on the stress-strain behavior of the samples.
authors.affiliation: Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Berchane
authors.forename: M J
authors.initials: MJ
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Kerr
authors.forename: N K H
authors.initials: NK
authors.lastname: Slater
authors.forename: F F
authors.initials: FF
authors.lastname: Jebrail
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001705:Bioprosthesis; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry; D004867:Equipment Design; D011109:Polymethacrylic Acids / Q000737:chemistry; D011312:Pressure; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength; D000267:Tissue Adhesions; D014867:Water / Q000737:chemistry; D014934:Wood
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011109:Polymethacrylic Acids; D014867:Water; C042535:polyglycidyl methacrylate; D012710:Serum Albumin, Bovine