title: Acute in vivo evaluation of an implantable continuous flow biventricular assist system.
abstract: An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose of this study was to evaluate the hemodynamic and physiologic performance of the combined implantation of the CorAide left ventricular assist device (LVAD) and the DexAide right ventricular assist device (RVAD). Acute hemodynamic responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation was performed by fixing the speed of one individual pump and increasing the speed of the other. Under all conditions, increased LVAD or RVAD speed resulted in increased pump flow. The predominant pathophysiologic effect of independently varying DexAide and CorAide pump speeds was that the left atrial pressure was very sensitive to increasing RVAD speed above 2,400 rpm, whereas the right atrial pressure demonstrated much less sensitivity to increasing LVAD speed. An increase in aortic pressure and RVAD flow was observed while increasing LVAD speed, especially under low contractility, ventricular fibrillation, high pulmonary artery pressure, and low circulatory blood volume conditions. In conclusion, a proper RVAD-LVAD balance should be maintained by avoiding RVAD overdrive. Additional studies will further investigate the performance of these pumps in chronic animal models.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Diyar
authors.initials: D
authors.lastname: Saeed
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Chiyo
authors.initials: C
authors.lastname: Ootaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Horai
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Catanese
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Fumoto
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhou
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Stephen
authors.initials: S
authors.lastname: Benefit
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D001011:Aorta / Q000473:pathology; D004867:Equipment Design; D006333:Heart Failure / Q000628:therapy*; D006352:Heart Ventricles / Q000473:pathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008422:Materials Testing; D008954:Models, Biological; D009200:Myocardial Contraction; D011312:Pressure; D011651:Pulmonary Artery / Q000473:pathology; D011673:Pulsatile Flow; D014693:Ventricular Fibrillation; D016276:Ventricular Function