[The signaling mechanism of glucocorticoid-induced T-cell apoptosis].
Glucocorticoid-induced T-cell apoptosis is supposed to require the change of gene expression. Enhanced expression of proapoptotic gene or inhibited expression of antiapoptotic gene seems to be necessary, although the real target gene remain to be elucidated. Recently, it was reported that extracellular signal-regulated protein kinase (ERK) inhibits glucocorticoid-induced T-cell apoptosis. This finding might provide new tools for overcoming glucocorticoid-resistance.
Okabe
Taijiro
T
Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University.
Takayanagi
Ryouichi
R
Yanase
Toshihiko
T
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D005938:Glucocorticoids / Q000502:physiology*; D051379:Mice; D013601:T-Lymphocytes / Q000502:physiology*
D005938:Glucocorticoids