Translating genetic findings into therapy in Parkinson disease.
In the last decade, current opinion for Parkinson disease (PD) etiology has swung from the hypothesis of a toxic/environmental disorder to understanding it as a highly heritable condition. Recent research conducted in families affected from PD has disclosed 6 genes that codify for proteins in pathways of neurodegeneration in PD. This review focuses in new drugs aimed to prevent the apparition and progression of the disease developed after the knowledge obtained from the genetic studies of PD, covering most recent and important patents.
Palomo
Sagrario M
SM
Sección de Neurología, Hospital la Mancha Centro, Alcazar de San Juan, Spain.
Jimenez-Escrig
Adriano
A
D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000235:genetics / Q000628:therapy; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D014176:Protein Biosynthesis / Q000502:physiology*
D009419:Nerve Tissue Proteins