A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma.
The incidence of oesophageal adenocarcinoma (EADC) is rapidly increasing in Western countries and obesity is thought to be a major risk factor. We examined the association between BMI and EADC, gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma in a cohort of approximately 500,000 people in the United States (US). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) with control for many potential confounders. We found that compared to people with a BMI of 18.5-25kg/m2, a BMI > or = 35 was associated with significantly increased risk of EADC, HR (95% CI)=2.27 (1.44-3.59) and gastric cardia adenocarcinoma 2.46 (1.60-3.80), but not gastric non-cardia adenocarcinoma 0.84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range.
Abnet
Christian C
CC
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States. abnetc@mail.nih.gov
Freedman
Neal D
ND
Hollenbeck
Albert R
AR
Fraumeni
Joseph F
JF
Leitzmann
Michael
M
Schatzkin
Arthur
A
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology*; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D001294:Attitude to Health; D015992:Body Mass Index; D002299:Cardia; D004812:Epidemiologic Methods; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014481:United States / Q000453:epidemiology