title: Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
abstract: Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a "magic bullet" drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
authors.affiliation: Department of Pharmaceutical Science, Northwestern Ohio Universities College of Pharmacy, Rootstown, OH 44272, USA.
authors.forename: Cornelis J
authors.initials: CJ
authors.lastname: Van der Schyf
authors.forename: Silvia
authors.initials: S
authors.lastname: Mandel
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Geldenhuys
authors.forename: Tamar
authors.initials: T
authors.lastname: Amit
authors.forename: Yael
authors.initials: Y
authors.lastname: Avramovich
authors.forename: Hailin
authors.initials: H
authors.lastname: Zheng
authors.forename: Mati
authors.initials: M
authors.lastname: Fridkin
authors.forename: Shunit
authors.initials: S
authors.lastname: Gal
authors.forename: Orly
authors.initials: O
authors.lastname: Weinreb
authors.forename: Orit
authors.initials: O
authors.lastname: Bar Am
authors.forename: Yotam
authors.initials: Y
authors.lastname: Sagi
authors.forename: Moussa B H
authors.initials: MB
authors.lastname: Youdim
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D002490:Central Nervous System / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents