title: Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.
abstract: Aging is inevitably associated with a progressive loss of muscle mass and strength, a condition also known as sarcopenia of aging. Although the precise mechanisms underlying this syndrome have not been completely elucidated, recent studies point toward several key cellular mechanisms that could contribute to age-associated muscle loss. Among these, mitochondrial dysfunction and deregulation of apoptotic signaling have emerged as critical players in the onset and progression of sarcopenia. Interestingly, calorie restriction, a well-known antiaging intervention, and, more recently, exercise training have been shown to beneficially affect both mitochondrial function and apoptotic signaling in skeletal muscle from young and old animals. Preliminary observations also indicate that even a small (8%) reduction in food intake may still provide protective effects against sarcopenia and cellular remodeling in aging skeletal muscle, with the advantage of being more applicable to human subjects than the traditional 30-40% restriction regimen. The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed.
authors.affiliation: Department of Aging and Geriatric Research, University of Florida Institute on Aging, College of Medicine, Gainesville, FL 32610, USA.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Marzetti
authors.forename: John M
authors.initials: JM
authors.lastname: Lawler
authors.forename: Asimina
authors.initials: A
authors.lastname: Hiona
authors.forename: Todd
authors.initials: T
authors.lastname: Manini
authors.forename: Arnold Y
authors.initials: AY
authors.lastname: Seo
authors.forename: Christiaan
authors.initials: C
authors.lastname: Leeuwenburgh
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D031204:Caloric Restriction; D002468:Cell Physiological Phenomena; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D023421:Models, Animal; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology*; D009133:Muscular Atrophy / Q000209:etiology* / Q000517:prevention & control; D010805:Physical Conditioning, Animal / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology; D012377:Rodentia; D015398:Signal Transduction / Q000502:physiology