Early radiation exposures and BRCA1-associated breast cancer in young women from Poland.
To study whether or not there is an adverse effect of early chest X-rays on breast cancer risk in breast cancer susceptibility gene 1 (BRCA1) carriers, we compared the histories of chest X-ray exposures before age 30 in 138 BRCA1 carriers with breast cancer with 158 age-matched women with breast cancer, but without a BRCA1 mutation. All cases were drawn from a national breast cancer research registry. Affected carriers reported more frequent chest X-ray use before age 20 than affected non-carriers (0.6 vs. 0.3; P = 0.01). Affected carriers had, on average, 1.8 chest X-rays before age 30 compared to an average of 1.0 for affected non-carriers (P = 0.002). The odds ratio for ever having had a chest X-ray below age 30, given a BRCA1 mutation, was 1.8 [95% confidence interval (CI) = 1.2-2.9; P = 0.01]. These observations support the hypothesis that early radiation exposure may be a risk factor for breast cancer in BRCA1 carriers.
Gronwald
Jacek
J
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Pijpe
Anouk
A
Byrski
Tomasz
T
Huzarski
Tomasz
T
Stawicka
Małgorzata
M
Cybulski
Cezary
C
van Leeuwen
Flora
F
Lubiński
Jan
J
Narod
Steven A
SA
D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D005192:Family Health; D005260:Female; D019398:Genes, BRCA1; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D016017:Odds Ratio; D011044:Poland; D011832:Radiation Injuries; D014965:X-Rays
D019313:BRCA1 Protein; C492913:BRCA1 protein, human