title: Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.
abstract: Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene-encoding retinoic acid receptor alpha (RARA) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta (STAT5B) is one of the alternative partners. We report a rare case of APL with STAT5B-RARA fusion transcript and the normal chromosome 17 on G-banding. Administration of all trans-retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. The molecular mechanism of fusion between STAT5B and RARA by chromosomal rearrangement is discussed based on the data from genome database. Clinical characteristics of APL with STAT5B-RARA are also discussed.
authors.affiliation: Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kusakabe
authors.forename: Kazumi
authors.initials: K
authors.lastname: Suzukawa
authors.forename: Toru
authors.initials: T
authors.lastname: Nanmoku
authors.forename: Naoshi
authors.initials: N
authors.lastname: Obara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okoshi
authors.forename: Harumi Y
authors.initials: HY
authors.lastname: Mukai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagasawa
mesh_terms: D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000032:analysis* / Q000737:chemistry / Q000235:genetics*; D050799:STAT5 Transcription Factor / Q000032:analysis* / Q000737:chemistry / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D015514:Oncogene Proteins, Fusion; D050799:STAT5 Transcription Factor; C456500:STAT5-RARalpha protein, human