Clinical value of urinary kidney biomarkers for estimation of renal impairment in elderly Chinese with essential hypertension.
The purpose of this work was to observe the excretion of specific types of urinary proteins and urinary enzymes in elderly essential hypertension patients, for early detection and targeted treatment of hypertensive nephropathy in the elderly. A total of 120 elderly essential hypertensive patients and 38 healthy elderly volunteers were involved. The urinary excretion rate of retinal-binding protein (RBP), transferrin (Tf), albumin (Alb), and urinary enzyme N-acetyl-beta-D-glucosaminidase (NAG) activity were determined. Patients were divided into two groups according to their creatinine clearance (Cockroft-Gault formula). There were 88 patients in group A, whose glomerular filtration rate (GFR) was >or=80 mL/min, and 32 patients in group B with a GFR <80 mL/min. Among the essential hypertensive patients, urinary excretion rates of RBP, Alb, Tf, and NAG were increased in both groups compared with the healthy controls. But the amount of urinary protein differed between group A and group B. The excretion rate of specific urinary protein and urinary enzyme had a positive relationship with the duration of course of hypertension. We believe that specific types of urinary proteins and urinary enzymes may be useful markers for early diagnosis of hypertensive nephropathy; they can also be regarded as a clinical indicator of the progression of hypertensive nephropathy, serving in the assessment of therapeutic effects.
Xu
Xunhui
X
Division of Nephrology, Zhongshan Hospital, Shanghia Medical College, Fudan University, Shanghai, China.
Fang
Yi
Y
Ji
Jun
J
Jiang
SuHua
S
Xing
DingGuang
D
Fei
ShaoHua
S
Ding
XiaoQiang
X
D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000652:urine*; D002352:Carrier Proteins / Q000652:urine; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000652:urine*; D007674:Kidney Diseases / Q000150:complications* / Q000201:enzymology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000652:urine
C020932:11-cis-retinal-binding protein; D015415:Biomarkers; D002352:Carrier Proteins; D012709:Serum Albumin; D014168:Transferrin; D000118:Acetylglucosaminidase