title: The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5.
abstract: The efficiency of CCR5 as an HIV coreceptor is strongly dependent on its level of cell surface expression. Therefore, it is of major importance to identify the factors that regulate cell surface density of CCR5. Among the chemokines that bind to CCR5, and induce its internalization, CCL5 is the most abundant in vivo. We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.
authors.affiliation: Institut de Génétique Humaine, CNRS UPR1142, France.
authors.forename: Yea-Lih
authors.initials: YL
authors.lastname: Lin
authors.forename: Clément
authors.initials: C
authors.lastname: Mettling
authors.forename: Pierre
authors.initials: P
authors.lastname: Portalès
authors.forename: Régine
authors.initials: R
authors.lastname: Rouzier
authors.forename: Jacques
authors.initials: J
authors.lastname: Clot
authors.forename: Jacques
authors.initials: J
authors.lastname: Reynes
authors.forename: Pierre
authors.initials: P
authors.lastname: Corbeau
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5; D012333:RNA, Messenger; D019713:Receptors, CCR5