title: Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.
abstract: Codon 129 polymorphism of the prion protein gene represents a major genetic risk factor for Creutzfeldt-Jakob disease (CJD). Both CJD and Alzheimer's disease (AD) are brain amyloidoses and it would be possible that codon 129 polymorphism plays a role in the susceptibility to AD. In order to investigate this polymorphism in AD the distribution of polymorphic codon 129 of the PRNP gene in 194 probable AD and 124 controls selected in Italy and 109 neuropathologically verified AD and 58 matched controls recruited in the USA was studied. No significant association was found for the PRNP polymorphism in AD compared to controls either in Probable or in Definite AD series even after stratification for APOE polymorphism. This study does not support a role of PRNP polymorphism as a susceptibility factor for AD.
authors.affiliation: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Poleggi
authors.forename: A
authors.initials: A
authors.lastname: Bizzarro
authors.forename: A
authors.initials: A
authors.lastname: Acciarri
authors.forename: P
authors.initials: P
authors.lastname: Antuono
authors.forename: S
authors.initials: S
authors.lastname: Bagnoli
authors.forename: E
authors.initials: E
authors.lastname: Cellini
authors.forename: G Dal
authors.initials: GD
authors.lastname: Forno
authors.forename: C
authors.initials: C
authors.lastname: Giannattasio
authors.forename: A
authors.initials: A
authors.lastname: Lauria
authors.forename: M G
authors.initials: MG
authors.lastname: Matera
authors.forename: B
authors.initials: B
authors.lastname: Nacmias
authors.forename: M
authors.initials: M
authors.lastname: Puopolo
authors.forename: D
authors.initials: D
authors.lastname: Seripa
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
authors.forename: D R
authors.initials: DR
authors.lastname: Wekstein
authors.forename: M
authors.initials: M
authors.lastname: Pocchiari
authors.forename: C
authors.initials: C
authors.lastname: Masullo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D003062:Codon; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics*; D014481:United States
chemical_list: D001057:Apolipoproteins E; D003062:Codon; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions