title: Histological benefits of virological response to peginterferon alfa-2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis.
abstract: BACKGROUND
  Patients with chronic hepatitis C virus and advanced fibrosis or cirrhosis are at risk for disease progression and hepatic decompensation.
  
  
  OBJECTIVE
  To determine the effects on hepatic histology of treatment with peginterferon alfa-2a (90 or 180 mug/week) or interferon alfa-2a (3 million units three times weekly) for 48 weeks in patients with paired biopsies.
  
  
  METHODS
  Liver biopsies were obtained at baseline and 6 months after end of treatment. Histological and virological responses were compared.
  
  
  RESULTS
  Patients attaining sustained virological response (n = 40) demonstrated the greatest improvements in fibrosis (-1.0, P < 0.0001) and inflammation (-0.65, P < 0.0001). Patients who cleared hepatitis C virus during treatment, but later relapsed (n = 59), experienced less improvement in fibrosis (-0.04, P < 0.0001) and inflammation (-0.14, P = 0.0768). Nonresponders (n = 85) showed no significant improvement in inflammation or fibrosis. Multiple regression analysis showed that the only factors contributing to improvement in fibrosis were sustained virological response (vs. nonresponder, P = 0.0005; vs. relapse, P = 0.7525) and body mass index < or =30 kg/m2 (P = 0.0995).
  
  
  CONCLUSIONS
  These findings indicate that virological response to peginterferon alfa-2a improves inflammation and fibrosis in hepatitis C virus patients with advanced fibrosis or cirrhosis. Improving virological response and maintaining ideal body weight are critical for achieving optimal histological outcomes in hepatitis C virus patients.
authors.affiliation: Section of Hepatology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA. greg.everson@uchsc.edu
authors.forename: G T
authors.initials: GT
authors.lastname: Everson
authors.forename: L
authors.initials: L
authors.lastname: Balart
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: R W
authors.initials: RW
authors.lastname: Reindollar
authors.forename: M L
authors.initials: ML
authors.lastname: Shiffman
authors.forename: G Y
authors.initials: GY
authors.lastname: Minuk
authors.forename: P J
authors.initials: PJ
authors.lastname: Pockros
authors.forename: S
authors.initials: S
authors.lastname: Govindarajan
authors.forename: E
authors.initials: E
authors.lastname: Lentz
authors.forename: E J
authors.initials: EJ
authors.lastname: Heathcote
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D016174:Hepacivirus / Q000187:drug effects; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D011994:Recombinant Proteins; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a