title: Intravitreal triamcinolone for the treatment of diabetic macular edema.
abstract: Diabetic macular edema is one of the leading causes of visual loss in first world countries and the first cause in diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study showed a significant benefit in using focal laser photocoagulation for the treatment of macular edema, more specifically defined as clinically significant macular edema. Nevertheless, progressive visual loss is found in the 26% of patients with diabetic macular edema treated with photocoagulation. The failure of laser treatment and the destructive nature of the therapy has forced researchers to pursue new alternatives including vitrectomy with or without internal limiting membrane peels, the use of proteinkinase C inhibitors, intravitreal injections of antibodies that inhibit the vascular endothelial growth factor, somatostatin analog, or the intravitreal injection with corticosteroids. Triamcinolone acetonide is glucocoticosteroid with antiangiogenic and antiedematous properties. Publications evaluating the safety and efficacy of intravitreal injection of triamcinolone in the treatment of diabetic macular edema show varying outcomes with respect to the increases of visual acuity and decreases in foveal thickness. Despite this, intravitreal triamcinolone is a treatment that has evolved quickly and is considered increasingly useful.
authors.affiliation: Ophthalmology Service, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. ciulla@usc.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Gómez-Ulla
authors.forename: Joaquín
authors.initials: J
authors.lastname: Marticorena
authors.forename: D Virgil
authors.initials: DV
authors.lastname: Alfaro
authors.forename: Maribel
authors.initials: M
authors.lastname: Fernández
authors.forename: Elizabeth Rodríguez
authors.initials: ER
authors.lastname: Méndez
authors.forename: Michelle
authors.initials: M
authors.lastname: Rothen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000601:surgery; D006207:Half-Life; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D014221:Triamcinolone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014822:Vitreous Body
chemical_list: D000893:Anti-Inflammatory Agents; D014221:Triamcinolone