Antimicrobial prenylated dihydrochalcones from Eriosema glomerata.
Two new natural dihydrochalcones exhibiting antimicrobial properties together with six known compounds were isolated from the Cameroonian medicinal plant Eriosema glomerata. The structures of the new dihydrochalcones were elucidated as 2',4'-dihydroxy-4-methoxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone and 2',4'-dihydroxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone by detailed spectroscopic analysis. The two new dihydrochalcones, named erioschalcones A ( 1) and B ( 2), demonstrated significant inhibitory activity against the microbial strains Bacillus megaterium, Escherichia coli, Chlorella fusca and Microbotryum violaceum.
Awouafack
Maurice D
MD
Department of Chemistry, University of Dschang, Dschang, Cameroon.
Kouam
Simeon F
SF
Hussain
Hidayat
H
Ngamga
Dieudonne
D
Tane
Pierre
P
Schulz
Barbara
B
Green
Ivan R
IR
Krohn
Karsten
K
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D047188:Chalcones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000460:Chlorophyta / Q000187:drug effects; D007887:Fabaceae; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D054876:Prenylation
D000890:Anti-Infective Agents; D047188:Chalcones; D010936:Plant Extracts; C015812:dihydrochalcone