title: Does ion release differ between hip resurfacing and metal-on-metal THA?
abstract: Modern metal-on-metal hip resurfacing was introduced as a bone-preserving method of joint reconstruction for young and active patients; however, the large diameter of the bearing surfaces is of concern for potential increased metal ion release. We hypothesized there were no differences in serum concentrations of chromium, cobalt, and molybdenum between patients who had metal-on-metal hip resurfacing (Group A; average head diameter, 48 mm; median followup, 24 months) and patients who had 28-mm metal-on-metal THA (Group B; median followup, 25 months). Serum concentrations also were compared with concentrations in healthy subjects. We identified no differences in ion levels between Groups A and B. A distinction was made according to gender. Women showed a higher chromium release in Group A whereas men had a higher cobalt release in Group B. Values obtained from Group A were higher than those of the control subjects. Our data suggest metal-on-metal bearings for THA should not be rejected because of concern regarding potential increased metal ion release; however, patients with elevated ion levels, even without loosening or toxicity, could be at higher risk and should be followed up periodically.
  
  
  METHODS
  Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: VI Division, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moroni
authors.forename: Lucia
authors.initials: L
authors.lastname: Savarino
authors.forename: Matteo
authors.initials: M
authors.lastname: Cadossi
authors.forename: Nicola
authors.initials: N
authors.lastname: Baldini
authors.forename: Sandro
authors.initials: S
authors.lastname: Giannini
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006618:Hip Dislocation, Congenital / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D025981:Hip Injuries / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D008982:Molybdenum / Q000097:blood; D009532:Nickel / Q000097:blood; D015207:Osteoarthritis, Hip / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D018579:Patient Selection; D011446:Prospective Studies; D011474:Prosthesis Design; D011859:Radiography; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008670:Metals; D002857:Chromium; D003035:Cobalt; D009532:Nickel; D008982:Molybdenum