[The effect of propranolol on portal hypertension].
The review of literature on propranolol (Inderal) pharmacological action on the portal vein pressure is reported in this article. The patients with liver cirrhosis and esophagogastric varices have 25-33% risk of initial bleeding, risk more than 70% of variceal re-bleeding and associated mortality over 50% in each episode. The use of nonselective beta adrenergic blockers according to previous data, descreases portal vein pressure and mostly prevents the initial bleeding. In the prevention of esophageal re-bleeding, nonselective beta adrenergic blockers (Inderal) are recommended in patients with relatively good liver function (Child's A and Child's B), while in liver failure with great ascites (Child's C) no beneficial effect is expected.
Kovacević
N
N
Tomić
D
D
Perisić-Savić
M
M
Grbić
R
R
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D017082:Portal Pressure / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol