title: Acanthamoeba keratitis: persistent organisms without inflammation after 1 year of topical chlorhexidine.
abstract: OBJECTIVE
  To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year.
  
  
  METHODS
  A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty.
  
  
  RESULTS
  Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring.
  
  
  CONCLUSIONS
  The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.
authors.affiliation: Department of Ophthalmology, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Gooi
authors.forename: Matthew
authors.initials: M
authors.lastname: Lee-Wing
authors.forename: Seymour
authors.initials: S
authors.lastname: Brownstein
authors.forename: Sherif
authors.initials: S
authors.lastname: El-Defrawy
authors.forename: W Bruce
authors.initials: WB
authors.lastname: Jackson
authors.forename: George
authors.initials: G
authors.lastname: Mintsioulis
mesh_terms: D015823:Acanthamoeba Keratitis / Q000188:drug therapy / Q000469:parasitology* / Q000601:surgery; D000287:Administration, Topical; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D003319:Corneal Stroma / Q000469:parasitology*; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D002710:Chlorhexidine