title: [The proper use of quinolones to the elderly patient with community-acquired pneumonia examined by Monte Carlo simulation].
abstract: Recently, proper use of antimicrobial agents for treatment of infections based on pharmacokinetics (PK)/ pharmacodynamics (PD) theory has been recommended to many clinical doctors. To consider the optimized administration method based on PK/PD theory for the elderly patients of gatifloxacin (GFLX), which was one of the oral respiratory quinolone antibacterial, Monte Carlo Simulation was conducted with community-acquired pneumonia and susceptibility data for Streptococcus pneumoniae (345 strains) collected by the second gatifloxacin surveillance study. From this results, the probabilities of achieving AUC/MIC 30 against pneumococcus for the elderly patients was 96.3% at twice-daily dosing of GFLX 100 mg, 97.2% at twice-daily dosing of GFLX 200 mg, therefore, it was suggested that the clinical effectiveness of the regimen of GFLX 100 mg was as well as the regimen of GFLX 200 mg.
authors.affiliation: Department of Laboratory Medicine, Nagasaki University Hospital.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Kazuko
authors.initials: K
authors.lastname: Fukushima
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kurihara
authors.forename: Masafumi
authors.initials: M
authors.lastname: Seki
authors.forename: Kouichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakeya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000077734:Gatifloxacin; D006801:Humans; D008875:Middle Aged; D009010:Monte Carlo Method; D011014:Pneumonia / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin