[The epidemiological and clinical characteristics of 1316 cases of acute pancreatitis in Guangdong region].
OBJECTIVE
To explore the clinical characteristics and pathogenetic patterns of acute pancreatitis (AP) in Guangdong region.


METHODS
Analysis and summary of the clinical data of 1316 AP patients admitted into the Sun Yat-sen Memorial Hospital of Sun Yat-sen University and the Guangdong Provincial People's Hospital between 1986 and 2005 were made.


RESULTS
The AP rates among 1986 - 1990, 1991 - 995, 1996 - 2000, 2001 - 2005 year subsections were 0.19%, 0.36%, 0.54% and 0.71%, respectively. 60.48% of the cases was associated with biliary tract disease and the rest were related to hyperlipidemic, idiopathic and alcoholic factors. Epigastric pain was the predominant clinical manifestation, with or without radiating lumbar and back pain. Digestive manifestations such as nausea and vomiting appeared in most of the patients. Contrast-enhanced dynamic computed tomography was a precise imaging technique for diagnosis and severity grading as well as for complication detection. 1104 patients received nonoperative treatment (integrated traditional and western medicine) with 24 deaths. 212 patients received operative treatment with 48 deaths.


CONCLUSIONS
The incidence of AP increased in the recent 20 years. The pathogenesis of AP is numerous and complicated, and biliary tract disease is still the main etiology. The imaging techniques are beneficial for early diagnosis and severity grading. Nonsurgical treatment integrating traditional and western medicine should be applied for early therapy. Strictly handling the indications for surgery, avoiding early surgery and rationally using endoscopic technique may help to gain satisfactory therapeutic efficacy.
Huang
Kai-hong
KH
Department of Gastroenterology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. hkhem@163.com
Lin
Ping
P
Nie
Sheng-li
SL
Liu
Jian-hua
JH
Wang
Ling-yun
LY
Chen
Qi-kui
QK
Zhu
Zhao-hua
ZH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007297:Inpatients / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D015995:Prevalence; D014057:Tomography, X-Ray Computed