title: Inflammatory mediators and home parenteral nutrition.
abstract: Individuals who have sustained intestinal failure due to trauma or disease are able to survive through the use of parenteral nutrition (PN). Although home PN (HPN) is a lifesaving therapy, patients may, over the long term, be at risk for liver, bone, and immune dysfunction. A limited number of human studies and a large number of animal studies suggest that there may be a chronic inflammatory condition and additionally a potentially lower T-lymphocyte immune function associated with PN administration. This article will primarily focus on a review of the limited clinical literature that examines the effect of long-term PN on the occurrence of inflammatory mediators in HPN patients, and will discuss the factors that are currently hypothesized to contribute to the potential inflammatory sequelae.
authors.affiliation: Department of Dietetics and Nutrition, University of Kansas Medical Center, 3901 Rainbow Boulevard 4096 DELP, Mail Stop 4013, Kansas City, KS 66160-7250, USA. mhise@kumc.edu
authors.forename: Mary
authors.initials: M
authors.lastname: Hise
authors.forename: Charlene
authors.initials: C
authors.lastname: Compher
authors.forename: John
authors.initials: J
authors.lastname: Brown
mesh_terms: D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D007410:Intestinal Diseases / Q000276:immunology* / Q000628:therapy; D016331:Parenteral Nutrition, Home / Q000009:adverse effects
chemical_list: D018836:Inflammation Mediators