title: Chimerism and tolerance in a recipient of a deceased-donor liver transplant.
abstract: Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney, Sydney, Australia.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Alexander
authors.forename: Neil
authors.initials: N
authors.lastname: Smith
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Deborah
authors.initials: D
authors.lastname: Verran
authors.forename: Albert
authors.initials: A
authors.lastname: Shun
authors.forename: Stuart
authors.initials: S
authors.lastname: Dorney
authors.forename: Arabella
authors.initials: A
authors.lastname: Smith
authors.forename: Boyd
authors.initials: B
authors.lastname: Webster
authors.forename: Peter John
authors.initials: PJ
authors.lastname: Shaw
authors.forename: Ahti
authors.initials: A
authors.lastname: Lammi
authors.forename: Michael O
authors.initials: MO
authors.lastname: Stormon
mesh_terms: D002648:Child; D005260:Female; D006086:Graft vs Host Disease; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D017114:Liver Failure, Acute / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D018183:Transplantation Chimera / Q000276:immunology*; D023001:Transplantation Tolerance / Q000235:genetics / Q000276:immunology*; D014184:Transplantation, Homologous