[Comparative study on characteristics of Chinese and Western medicine for treatment of rheumatoid arthritis regarding cartilage erosion related blood biochemical and immunological factors].
OBJECTIVE
To analyse the cartilage erosion related blood biochemical and immune factors in rheumatoid arthritis (RA) and to explore the special influences of Chinese medicine (CM) and Western medicine (WM) on these factors.


METHODS
Three hundred and ninety-seven patients, with confirmed diagnosis of active RA, were randomly assigned to the WM group (194 patients) and the CM group (203 patients). The WM applied covered non-steroid anti-inflammatory agents and slow acting medicine; and the CM given included basic remedy and syndrome differentiating medication. Related blood biochemical and immunological indexes were determined before and after treatment to screen out the cartilage erosion related factors and to compare the influence of CM and WM on them.


RESULTS
Patients' peripheral red blood cell (RBC) and platelet (PLT) count were changed closely along with their degree of cartilage erosion. RBC count increased in the CM group and PLT count lowered in the WM group after treatment, all showed statistical significance; comparison of the two indexes between the two groups showed that statistical difference presented in RBC but not in PLT count.


CONCLUSIONS
Both WM and CM can ameliorate the cartilage erosive factor in RA, but they are acting in different ways.
Liu
Xue-Wen
XW
Institute of Basic Medicine, China Academy of Chinese Medical Sciences, Beijing.
Zha
Qing-Lin
QL
He
Yi-Ting
YT
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D008517:Phytotherapy; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D055815:Young Adult
D018501:Antirheumatic Agents; D004365:Drugs, Chinese Herbal; D011241:Prednisone; D008727:Methotrexate