Orthopedic implant used as drug delivery system: clinical situation and state of the research.
A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part, an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation.
Pioletti
Dominique P
DP
Laboratory of Biomechanical Orthopedics EPFL-HOSR, Institute of Translational Biomechanics, Ecole Polytechnique Fédérale Lausanne, Switzerland. dominique.pioletti@epfl.ch
Gauthier
Olivier
O
Stadelmann
Vincent A
VA
Bujoli
Bruno
B
Guicheux
Jérôme
J
Zambelli
Pierre-Yves
PY
Bouler
Jean-Michel
JM
D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D004343:Drug Implants; D006801:Humans; D009983:Orthopedic Equipment; D009984:Orthopedic Fixation Devices; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D004343:Drug Implants