title: Dalbavancin: a novel once-weekly lipoglycopeptide antibiotic.
abstract: The increasing prevalence of drug-resistant gram-positive cocci, such as methicillin-resistant Staphylococcus aureus, has underscored the need for new agents for the treatment of this type of infection. Dalbavancin, a new lipoglycopeptide, has the desirable characteristics of increased in vitro activity, compared with vancomycin, for most gram-positive pathogenic bacteria, as well as an extremely long half-life, permitting once-weekly intravenous dosing. Clinical studies comparing linezolid with 2 doses of dalbavancin have shown comparable efficacy for the treatment of skin and soft-tissue infection. Dalbavancin has also proven to be effective for therapy of catheter-related bloodstream infections. It has an excellent safety profile in studies to date. Dalbavancin will likely have a significant role in outpatient intravenous therapy for patients with potentially serious drug-resistant gram-positive coccal infections.
authors.affiliation: Department of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA.
authors.forename: Marianne
authors.initials: M
authors.lastname: Billeter
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Zervos
authors.forename: Anne Y
authors.initials: AY
authors.lastname: Chen
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Dalovisio
authors.forename: Changa
authors.initials: C
authors.lastname: Kurukularatne
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D017192:Skin Diseases, Bacterial / Q000188:drug therapy; D018461:Soft Tissue Infections / Q000188:drug therapy; D017334:Teicoplanin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; C469289:dalbavancin