New (fluorescent) light on poliovirus entry.
To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.
Bergelson
Jeffrey M
JM
Division of Infectious Diseases, Children's Hospital of Philadelphia, Abramson Research Center 1202E, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. bergelson@email.chop.edu
D021941:Caveolae / Q000821:virology; D022163:Clathrin-Coated Vesicles / Q000821:virology; D003593:Cytoplasm / Q000821:virology; D004705:Endocytosis; D042783:Endothelial Cells / Q000821:virology; D005456:Fluorescent Dyes / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008856:Microscopy, Fluorescence; D017955:Poliovirus / Q000502:physiology* / Q000648:ultrastructure; D012367:RNA, Viral / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D013194:Staining and Labeling; D014771:Virion / Q000378:metabolism; D053586:Virus Internalization
D005456:Fluorescent Dyes; D008565:Membrane Proteins; D012367:RNA, Viral; D011991:Receptors, Virus; C066100:poliovirus receptor