title: Fatigue after traumatic brain injury and its impact on participation and quality of life.
abstract: OBJECTIVE
  To examine the relationships between post-TBI fatigue (PTBIF) and comorbid conditions, participation in activities, quality of life, and demographic and injury variables.
  
  
  METHODS
  223 community-dwelling individuals with mild to severe TBI and 85 noninjured controls.
  
  
  METHODS
  Global Fatigue Index (GFI), Beck Depression Inventory (BDI-II), McGill Pain Questionnaire (MPQ), Pittsburgh Sleep Quality Inventory (PSQI), Participation Objective Participation Subjective (POPS), SF-36, Life-3.
  
  
  METHODS
  Data were collected through interviews and administration of self-report measures as part of a study of PTBIF.
  
  
  RESULTS
  Fatigue was more severe and prevalent in individuals with TBI, and more severe among women. It was not correlated with other demographic and injury variables. Once overlap in measurement instruments' content was removed, depression, pain, and sleep problems accounted for approximately 23% of the variance in fatigue in those with TBI compared to 58% of the variance in the control group. PTBIF was correlated with health-related quality of life and overall quality of life, but was not generally related to participation in major life activities.
  
  
  CONCLUSIONS
  PTBIF has significant impact on well-being and quality of life and cannot be accounted for by comorbid conditions alone, suggesting that it is related to brain injury itself. It appears to be unrelated to demographic and injury variables other than gender. PTBIF does not limit the quantity and frequency of participation. Future research should focus on the relationship between fatigue and the quality of participation.
authors.affiliation: Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Cantor
authors.forename: Teresa
authors.initials: T
authors.lastname: Ashman
authors.forename: Wayne
authors.initials: W
authors.lastname: Gordon
authors.forename: Annika
authors.initials: A
authors.lastname: Ginsberg
authors.forename: Clara
authors.initials: C
authors.lastname: Engmann
authors.forename: Matthew
authors.initials: M
authors.lastname: Egan
authors.forename: Lisa
authors.initials: L
authors.lastname: Spielman
authors.forename: Marcel
authors.initials: M
authors.lastname: Dijkers
authors.forename: Steve
authors.initials: S
authors.lastname: Flanagan
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001930:Brain Injuries / Q000150:complications*; D015897:Comorbidity; D005221:Fatigue / Q000209:etiology*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D011788:Quality of Life