Nanoparticles as nonviral gene delivery vectors.
Gene therapy, as therapeutic treatment to genetic or acquired diseases, is attracting much interest in the research community, leading to noteworthy developments over the past two decades. Although this field is still dominated by viral vectors, nonviral vectors have recently received an ever increasing attention in order to overcome the safety problems of their viral counterpart. This review presents the biological aspects involved in the gene delivery process and explores the recent developments and achievements of nonviral gene carriers.
Ragusa
Andrea
A
Laboratory of Glyconanotechnology, IIQ-CSIC, Americo Vespucio 49, 41092 Seville, Spain. andrea.ragusa@unile.it
García
Isabel
I
Penadés
Soledad
S
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D018390:Gene Targeting / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use*; D043942:Nanotubes; D014162:Transfection / Q000379:methods*