title: Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator.
abstract: A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.
authors.affiliation: Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom. matthewb.avison@bris.ac.uk.
authors.forename: Aki
authors.initials: A
authors.lastname: Okazaki
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Avison
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D004790:Enzyme Induction; D015964:Gene Expression Regulation, Bacterial; D005809:Genes, Regulator; D006801:Humans; D009154:Mutation; D020615:Stenotrophomonas maltophilia / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D047090:beta-Lactams; C071526:AmpR protein, Bacteria; C088032:beta-lactamase L1; C425104:beta-lactamase L2; D001618:beta-Lactamases