High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis.
High tissue matrix metalloproteinase (MMP) activity has been reported to be associated with atherosclerosis and plaque rupture. The aim of this study was to elucidate the diagnostic value of serum MMP-1 in carotid stenosis and its dynamic change after stenting. We measured high-sensitivity C-reactive protein (hs-CRP) and MMP-1 in 37 patients with carotid stenosis (>or= 50%) and 84 controls. In 30 patients who underwent stenting, MMP-1 and hs-CRP were assessed immediately after stenting. We found that patients with carotid stenosis exhibited significantly higher MMP-1 compared with controls, but there was no difference in hs-CRP. Moreover, MMP-1 was elevated immediately after stenting. In multivariate analyses, MMP-1 was negatively correlated with statin and angiotensin converting enzyme inhibitor/angiotensin-II receptor blocker use in controls. In conclusion, higher levels and rapid surge after stenting in patients with carotid stenosis indicate that MMP-1 is an important composition of plaques, and suggest its potential role in the assessment of plaque burden and stability of carotid stenosis.
Wu
Yen-Wen
YW
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yang
Wei-Shiung
WS
Chen
Ming-Fong
MF
Lee
Bai-Chin
BC
Hung
Chi-Sheng
CS
Liu
Yu-Chun
YC
Jeng
Jiann-Shing
JS
Huang
Por-Jau
PJ
Kao
Hsien-Li
HL
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016893:Carotid Stenosis / Q000201:enzymology* / Q000628:therapy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D018709:Statistics, Nonparametric; D015607:Stents
D015415:Biomarkers; D002097:C-Reactive Protein; D020781:Matrix Metalloproteinase 1