Vascular cytochrome p450 enzymes: physiology and pathophysiology.
Cytochrome P450 epoxygenases and the soluble epoxide hydrolase are enzymes that regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids derived from arachidonic acid. Epoxyeicosatrienoic acids are recognized as lipid mediators that participate in vascular signaling processes such as the acute regulation of vascular tone and the processes of inflammation and angiogenesis.
Fleming
Ingrid
I
Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, D-60590 Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000502:physiology*; D004851:Epoxide Hydrolases / Q000502:physiology; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D007249:Inflammation / Q000201:enzymology; D018919:Neovascularization, Physiologic / Q000502:physiology; D014652:Vascular Diseases / Q000201:enzymology / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology
D006893:Hydroxyeicosatetraenoic Acids; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D004851:Epoxide Hydrolases