Migration of Apicomplexa across biological barriers: the Toxoplasma and Plasmodium rides.
The invasive stages of Apicomplexa parasites, called zoites, have been largely studied in in vitro systems, with a special emphasis on their unique gliding and host cell invasive capacities. In contrast, the means by which these parasites reach their destination in their hosts are still poorly understood. We summarize here our current understanding of the cellular basis of in vivo parasitism by two well-studied Apicomplexa zoites, the Toxoplasma tachyzoite and the Plasmodium sporozoite. Despite being close relatives, these two zoites use different strategies to reach their goal and establish infection.
Tardieux
Isabelle
I
Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France. tardieux@cochin.inserm.fr
Ménard
Robert
R
D000818:Animals; D016782:Apicomplexa / Q000472:pathogenicity / Q000502:physiology*; D001808:Blood Vessels / Q000033:anatomy & histology / Q000469:parasitology; D002465:Cell Movement / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D008099:Liver / Q000033:anatomy & histology / Q000469:parasitology; D008288:Malaria / Q000503:physiopathology; D010961:Plasmodium / Q000472:pathogenicity / Q000502:physiology*; D015800:Protozoan Proteins / Q000378:metabolism; D034101:Sporozoites / Q000502:physiology*; D014122:Toxoplasma / Q000472:pathogenicity / Q000502:physiology*; D014123:Toxoplasmosis / Q000503:physiopathology
D015800:Protozoan Proteins