title: A Phytochemically characterized extract of Cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils.
abstract: In the present study, we investigated effects of the dried, hot-water extract of Cordyceps militaris (CME) and its major metabolite (cordycepin) against ischemic damage. The repeated treatment with CME protected hippocampal CA1 pyramidal neurons from ischemic damage in gerbils. The treatment with CME or cordycepin in gerbils reduced 4-hydroxy-2-nonenal (a marker of lipid peroxidation) immunoreactivity and levels in the ischemic CA1 region. Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 immunoreactive microglia in the vehicle-treated ischemic group were activated in the CA1 region 4 days after ischemia/reperfusion, whereas in the CME- or cordycepin-treated ischemic group, their activation was significantly decreased. These results suggest that the repeated treatment with CME protects against neuronal damage from ischemia/reperfusion by reducing oxidative damage.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea.
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Soon Sung
authors.initials: SS
authors.lastname: Lim
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Yeon Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Ho Gyoung
authors.initials: HG
authors.lastname: Kim
authors.forename: Il-Jun
authors.initials: IJ
authors.lastname: Kang
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Jinseu
authors.initials: J
authors.lastname: Park
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000225:Adenine / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology; D001930:Brain Injuries / Q000517:prevention & control*; D032661:Cordyceps / Q000737:chemistry*; D003839:Deoxyadenosines / Q000302:isolation & purification* / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000293:injuries* / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000502:physiology*
chemical_list: D000447:Aldehydes; D000935:Antifungal Agents; D001688:Biological Products; D003839:Deoxyadenosines; C058120:cordycepin; D000225:Adenine; C027576:4-hydroxy-2-nonenal; D000241:Adenosine