title: The association between polypronucleate zygote formation with certain motion characteristics of sperm and IVF outcome.
abstract: OBJECTIVE
  To determine the efficiency of sperm motion characteristics as predictors for normal (2PN) and polypronulceate (PPN) zygotes in IVF.
  
  
  METHODS
  A retrospective cohort analysis for a total of 230 couples undergoing IVF treatment in a single infertility center.
  
  
  RESULTS
  Subsequent to semen analysis and hemizona assay, unexpected fertilization failure would appear to have occurred only extremely rarely (1/236, 0.4%). The rate of PPN, however, did arise and appeared to be related to certain sperm motion characteristics, such as lateral head displacement and concentration of progressive motile sperm. Interestingly, the patients featuring a high PPN rate (>20%) was associated with a greater pregnancy rate than those featuring a low PPN rate (<20%).
  
  
  CONCLUSIONS
  The sperm motion characteristics examined herein could be utilized to predict the rate of PPN in IVF. In order to enhance the rate of 2PN and maintain the relative high rate of clinical pregnancy, an efficient method needs further investigation and development.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lee
authors.forename: Chung-Hsien
authors.initials: CH
authors.lastname: Liu
authors.forename: Chun-Chia
authors.initials: CC
authors.lastname: Huang
authors.forename: Hsui-Hui
authors.initials: HH
authors.lastname: Chen
authors.forename: Shee-Uan
authors.initials: SU
authors.lastname: Chen
authors.forename: Maw-Sheng
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013084:Sperm-Ovum Interactions; D015053:Zygote / Q000166:cytology* / Q000378:metabolism