title: Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson disease, and Alzheimer disease.
abstract: OBJECTIVE
  The present study sought to investigate lower urinary tract symptoms and urodynamic and cystometric findings in Parkinson disease (PD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD).
  
  
  METHODS
  Included were patients with frequency, urgency, incontinence, and nocturia, without major bladder outflow obstruction. The protocol comprised physical examination, urine analysis, prostate specific antigen, 24-hours frequency of micturition, mean voided volume (MVV), free flow before instrumentation (Qmax(before)), post-void residual volume (PVR), and cystometry.
  
  
  RESULTS
  Fifteen patients with DLB and PD and 16 patients with AD were examined. MVV, PVR, Qmax(before) and with transurethral catheter, cystometric bladder capacity, and detrusor pressor at maximum flow were similar in the three groups and corresponded to values of the general elderly population. Urge episodes and urge incontinence were observed in 93 and 53% of the patients with DLB, 53 and 27% of the patients with PD, and 19 and 12% of the patients with AD, and detrusor overactivity in 92% of the patients with DLB, 46% of the patients with PD, and 40% of the patients with AD.
  
  
  CONCLUSIONS
  Urgency and urge incontinence suggest detrusor overactivity, which was more prevalent in dementia with Lewy bodies than in Parkinson disease and Alzheimer disease, whereas mean voided volume, free flow, cystometric bladder capacity, and detrusor pressor were similar in the groups. Frequency of micturition could not be reliably assessed in patients with dementia.
authors.affiliation: Department of Neurology, Innsbruck Medical University, Austria. gerhard.ransmayr@akh.linz.at
authors.forename: G N
authors.initials: GN
authors.lastname: Ransmayr
authors.forename: S
authors.initials: S
authors.lastname: Holliger
authors.forename: K
authors.initials: K
authors.lastname: Schletterer
authors.forename: H
authors.initials: H
authors.lastname: Heidler
authors.forename: M
authors.initials: M
authors.lastname: Deibl
authors.forename: W
authors.initials: W
authors.lastname: Poewe
authors.forename: H
authors.initials: H
authors.lastname: Madersbacher
authors.forename: G
authors.initials: G
authors.lastname: Kiss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D010808:Physical Examination; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D014549:Urinary Incontinence / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D053202:Urinary Incontinence, Urge / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D014551:Urinary Tract / Q000294:innervation / Q000503:physiopathology*; D014554:Urination / Q000502:physiology; D014555:Urination Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*