Structural modifications of the bronchial epithelium in asthma.
A complex of structural changes in the parenchymatous and stromal compartments, characteristic of the primary degenerative process (bronchial epithelium degeneration and subsequent diffuse atrophy, reactive sclerosis of the stroma) develops in the large bronchi in asthma. Induction of the regeneratory reactions of the bronchial epithelium with synchronously developing reorganization of the stroma (loosening of the connective tissue and stimulation of its vascularization) is shown during correction of asthma. Association of positive structural changes with lymphoid tissue hyperplasia in the bronchial wall can be interpreted in the context of significant role of lymphocytes in induction of the regeneratory reactions.
Nepomnyashchikh
G I
GI
Laboratory of Ultrastructural Bases of Pathology, Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. gi_nepom@soramn.ru
Aidagulova
S V
SV
Trubnikova
N V
NV
Volkova
D V
DV
Bakarev
M A
MA
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000473:pathology*; D001980:Bronchi / Q000473:pathology* / Q000648:ultrastructure; D001999:Bronchoscopy; D004848:Epithelium / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D012189:Retrospective Studies