[Expanding the liver donor pool through extended-criteria donation].
Due to the great shortage of donor organs in liver transplantation, the utilization of liver allografts from extended-criteria donors is gaining importance. An accepted precise definition of extended-criteria donors remains elusive. The most frequent criteria include high donor age, graft steatosis, and prolonged ICU stay. The influence of using extended-criteria donors on post-transplant outcome has yet to be defined. Its possibly higher rates of graft dysfunction and impaired graft and recipient survival are countered by a proven reduction in waiting-list mortality. Moreover, recipient factors of particular risk such as high MELD (model for endstage liver disease) score and underlying hepatitis C infection have to be defined and taken into consideration.
Pratschke
J
J
Abteilung für Allgemein-, Visceral- und Transplantatonschirurgie, Charité-Universitätsmedizin Berlin,Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin.
Mittler
J
J
Neuhaus
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D005234:Fatty Liver / Q000401:mortality / Q000601:surgery; D005260:Female; D005858:Germany; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D012307:Risk Factors; D014019:Tissue Donors / Q000600:supply & distribution*