title: Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort.
abstract: Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. lmucci@hsph.harvard.edu
authors.forename: Lorelei A
authors.initials: LA
authors.lastname: Mucci
authors.forename: Yudi
authors.initials: Y
authors.lastname: Pawitan
authors.forename: Francesca
authors.initials: F
authors.lastname: Demichelis
authors.forename: Katja
authors.initials: K
authors.lastname: Fall
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Stark
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.forename: Swen-Olof
authors.initials: SO
authors.lastname: Andersson
authors.forename: Ove
authors.initials: O
authors.lastname: Andrén
authors.forename: Anna S
authors.initials: AS
authors.lastname: Eisenstein
authors.forename: Lars
authors.initials: L
authors.lastname: Holmberg
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kantoff
authors.forename: Sven
authors.initials: S
authors.lastname: Perner
authors.forename: Meir J
authors.initials: MJ
authors.lastname: Stampfer
authors.forename: Jan-Erik
authors.initials: JE
authors.lastname: Johansson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rubin
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015331:Cohort Studies; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000401:mortality*; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen