title: Willingness of Chinese injection drug users to participate in HIV vaccine trials.
abstract: BACKGROUND
  Chinese injection drug users (IDUs) may be a proper candidate population for HIV vaccine trials.
  
  
  OBJECTIVE
  To evaluate willingness to participate (WTP) in HIV vaccine trials among Chinese IDUs.
  
  
  METHODS
  Questionnaire interviews were completed among 401 IDUs in Urumqi City in northwestern China in 2005.
  
  
  RESULTS
  Overall 74.3% of participants said that they would be definitely willing to participate in HIV vaccine trials, 17.7% were probably willing, 6.2% were probably not willing, and remaining 1.8% were definitely not willing to join. Multivariate logistic regression analysis demonstrated that WTP was positively associated with having ever had sex with a drug use partner (adjusted odds ratio [AOR]: 1.8; 95% confidence interval [CI]: 1.04, 3.2), sharing needle and syringe with a new drug use partner in the past 3 months (AOR: 3.8; 95% CI: 1.2, 11.7), perceived family support for participation (AOR: 7.4; 95% CI: 4.3, 12.7), and perceived vaccine protection against HIV infection (AOR: 16.1; 95% CI: 3.7, 70.8), and was negatively associated with perceived risk of social stigma and isolation for participation (AOR: 0.3; 95% CI: 0.2, 0.5).
  
  
  CONCLUSIONS
  The stated WTP in hypothetical HIV vaccine trials was high among Chinese IDUs. Further studies are needed to evaluate actual enrollment into the trials.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), 27 Nanwei Road, Xuanwu District, Beijing 100050, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Han-Zhu
authors.initials: HZ
authors.lastname: Qian
authors.forename: Baoling
authors.initials: B
authors.lastname: Rui
authors.forename: Lijiang
authors.initials: L
authors.lastname: Zhang
authors.forename: Junling
authors.initials: J
authors.lastname: Zhu
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Guan
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Wang
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Li
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D016915:AIDS Vaccines; D000328:Adult; D002681:China; D002986:Clinical Trials as Topic; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D019359:Knowledge; D008297:Male; D016485:Needle Sharing; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D012044:Regression Analysis; D012309:Risk-Taking; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D016915:AIDS Vaccines