title: Clostridium butyricum sepsis in an injection drug user with an indwelling central venous catheter.
abstract: Clostridium novyi has been associated with a large outbreak of severe infections in injection drug users. A case of bacteraemia with Clostridium butyricum in an injection drug user is reported. During treatment for Staphylococcus aureus osteomyelitis, the patient used an indwelling central venous catheter to inject cocaine. He was admitted with C. butyricum sepsis that responded to broad spectrum antibiotics, including vancomycin. Local investigation for other cases was unrevealing; however, growth of an unusual pathogen in clinical specimens should be investigated as it may represent a sentinel event with public health implications.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.|Department of Medicine, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.|Denver Public Health Department, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Gardner
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.|Denver Public Health Department, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Kestler
authors.affiliation: Department of Medicine, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Beieler
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.|Department of Medicine, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.|Denver Public Health Department, Denver Health and Hospital Authority, 605 Bannock Street, Denver, CO 80204, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Belknap
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002405:Catheterization, Central Venous; D003015:Clostridium Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D046972:Clostridium butyricum / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000150:complications; D015819:Substance Abuse, Intravenous; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents