Sporadic multiple cerebral cavernomatosis: report of a case and review of literature.
OBJECTIVE
Cerebral cavernous malformations (CCM) are vascular malformations causing seizures and cerebral hemorrhages. They occur in sporadic and familial forms. Familial cases are associated with a high frequency of multiple lesions, which are less frequently associated with sporadic cases.


METHODS
We report a 46-year-old woman presenting with epilepsy with multiple cerebral cavernomatosis on MRI. Because she had had a previous liver transplantation operation, and received immunosuppressants, she was not advised to have a brain operation. However, she had to be operated as a result of a bleeding in one of her cerebral cavernomas. The histologic diagnosis was cavernoma. She has been seizure free after the operation with levetiracetam therapy for the last 17 months. She had no positive family history for both epilepsy and cavernomatosis.


CONCLUSIONS
When multiple cerebral cavernomatosis are identified in a patient, a detailed neurologic family history should be sought despite the possibility of its being a sporadic case. Our main intention is to present a patient who is surgically controversial and to point out the importance of genetic heredity.
Coban
Arzu
A
Department of Neurology, Istanbul School of Medicine, University of Istanbul, Istanbul, Turkey. arzucoban2002@yahoo.com
Gurses
Candan
C
Bilgic
Bilge
B
Sencer
Serra
S
Karasu
Aykut
A
Bebek
Nerses
N
Baykan
Betul
B
Hepgul
Kemal T
KT
Gokyigit
Aysen
A
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D020786:Hemangioma, Cavernous, Central Nervous System / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D000075927:KRIT1 Protein; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D019635:Neurosurgical Procedures; D010889:Piracetam / Q000031:analogs & derivatives / Q000627:therapeutic use; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000927:Anticonvulsants; D000075927:KRIT1 Protein; C107928:KRIT1 protein, human; D008869:Microtubule-Associated Proteins; D011518:Proto-Oncogene Proteins; D000077287:Levetiracetam; D010889:Piracetam