title: Correlation between oxidation potentials and inhibitory effects on Epstein-Barr virus activation of flavonoids.
abstract: The oxidation potentials of fifteen flavonoids in phosphate buffer at pH 7.2 were determined by cyclic voltammetry. A good correlation was found between these oxidation potentials and the ability of flavonoids to inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Furthermore, multiple regression analysis revealed that the solvent-accessible surface area (SASA) was a useful parameter for estimating the inhibitory effects of flavonoids on EBV-EA activation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. j-koyama@kobepharma-u.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Koyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Morita
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Takao
authors.initials: T
authors.lastname: Konoshima
authors.forename: Midori
authors.initials: M
authors.lastname: Takasaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Osakai
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D004563:Electrochemistry; D005419:Flavonoids / Q000493:pharmacokinetics*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D010084:Oxidation-Reduction
chemical_list: D005419:Flavonoids