Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women.
Among the 51,823 postmenopausal women in the Swedish Mammography Cohort, we investigated breast cancer risk in relation to the FFQ-based estimated lignan intake by oestrogen receptor (ER) and progesterone receptor (PR) subtypes. A significant 17% risk reduction for breast cancer overall in the high lignan quartile was observed, especially among PMH user (P interaction<0.010), but no heterogeneity across ER/PR subtypes.
Suzuki
R
R
Division of Nutritional Epidemiology, The Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Rylander-Rudqvist
T
T
Saji
S
S
Bergkvist
L
L
Adlercreutz
H
H
Wolk
A
A
D001943:Breast Neoplasms / Q000453:epidemiology*; D015331:Cohort Studies; D004032:Diet; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D017705:Lignans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000453:epidemiology*; D017698:Postmenopause; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D012307:Risk Factors; D013548:Sweden
D017705:Lignans; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone