title: Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.
abstract: This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the issues associated with the treatment of hospital infections caused by Gram-negative bacteria. The group discussed the severe clinical problems arising from the emergence of antibiotic resistance in these bacteria and the lack of new antibacterial agents to challenge the threat. The discovery of new drugs active against hospital-acquired Gram-negative bacteria is essential to prevent a future medical and social catastrophe. An important strategy to promote drug discovery will be the development of focused cooperations between academic institutions and small pharmaceutical companies.
authors.affiliation: Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK. i.chopra@leeds.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Chopra
authors.forename: Christopher
authors.initials: C
authors.lastname: Schofield
authors.forename: Martin
authors.initials: M
authors.lastname: Everett
authors.forename: Alex
authors.initials: A
authors.lastname: O'Neill
authors.forename: Keith
authors.initials: K
authors.lastname: Miller
authors.forename: Mark
authors.initials: M
authors.lastname: Wilcox
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Frère
authors.forename: Mike
authors.initials: M
authors.lastname: Dawson
authors.forename: Lloyd
authors.initials: L
authors.lastname: Czaplewski
authors.forename: Uros
authors.initials: U
authors.lastname: Urleb
authors.forename: Patrice
authors.initials: P
authors.lastname: Courvalin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents