Organocatalysed asymmetric Mannich reactions.
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.
Verkade
Jorge M M
JM
Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, NL-6525 ED Nijmegen, The Netherlands.
van Hemert
Lieke J C
LJ
Quaedflieg
Peter J L M
PJ
Rutjes
Floris P J T
FP
D000085:Acetates / Q000737:chemistry; D000143:Acids / Q000737:chemistry; D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D000085:Acetates; D000143:Acids; D000438:Alcohols; D000447:Aldehydes; D000588:Amines; D004952:Esters; D007097:Imines; D007659:Ketones