title: New options in the treatment of locally advanced head and neck cancer: role for induction chemotherapy.
abstract: Advanced locoregional disease is the most frequent clinical situation in Head and Neck cancer. The standard of care for most clinicians is a multidisciplinary treatment with concomitant chemotherapy plus radiotherapy (CRT). However, retrospective studies have shown that in patients treated with CRT there was a relative increase in systemic relapse due to a lack of systemic control. For this reason a renewed interest has appeared for the incorporation of induction chemotherapy in the treatment of locally advanced Head and Neck Cancer. Furthermore new combination regimens with taxanes have shown to be more active than the classical cisplatin and 5-fluorouracil induction regimen. For these reasons ongoing trials are comparing induction chemotherapy followed by chemoradiotherapy with chemoradiotherapy alone. In this review, we will discuss the currently available data that support the design of these clinical trials as well as the future role of new agents in this clinical situation.
authors.affiliation: Servicio de Oncologia Médica, Hospital Universitario de Salamanca, Salamanca, Spain. jjcruz@usal.es
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Cruz
authors.forename: Alberto
authors.initials: A
authors.lastname: Ocaña
authors.forename: Miguel
authors.initials: M
authors.lastname: Navarro
authors.forename: Elvira Del
authors.initials: ED
authors.lastname: Barco
authors.forename: Emilio
authors.initials: E
authors.lastname: Fonseca
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D015201:Meta-Analysis as Topic; D020360:Neoadjuvant Therapy / Q000379:methods*; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012074:Remission Induction