Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats.
OBJECTIVE
To study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis (CAG) rats.


METHODS
Intervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa.


RESULTS
Mica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands. Especially, better effects were shown in the mid and high dose groups.


CONCLUSIONS
Mica has the pharmacological action of protecting the gastric mucosa, enhancing blood flow of the gastric mucosa, and consequently improving the inflammatory responses of the gastric mucosa. One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion (gastrin and somatostatin) by increasing the number of chief and parietal cells as well as G and D cells.
Zhu
Fang-shi
FS
Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing, China. zhufs@tom.com
Si
Jian-min
JM
Wang
Liang-jing
LJ
Wang
Dong-fei
DF
Chen
Ping
P
D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D002452:Cell Count; D019872:Chief Cells, Gastric / Q000187:drug effects / Q000473:pathology; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D019863:Gastrin-Secreting Cells / Q000187:drug effects / Q000473:pathology; D005757:Gastritis, Atrophic / Q000473:pathology*; D007249:Inflammation; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000473:pathology; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D019864:Somatostatin-Secreting Cells / Q000187:drug effects / Q000473:pathology
D000538:Aluminum Silicates; D011208:Powders; C011934:mica