[Moderate hypoglycemia in the preterm infant: is it relevant?].
Glucose monitoring and management of hypoglycaemia in preterm infants remain controversial. However, recent animal studies have shown that hypoglycaemia is associated to increased generation of reactive oxygen and nitrogen species, to inhibition of cellular maturation and to apoptosis in brain. Despite potential consequences of hypoglycaemia on brain development in preterm infants, only few studies are available on this topic. Available clinical studies on neurological development of hypoglycaemic preterm infants are not conclusive but suggest detrimental effect of repeated mild hypoglycaemia on brain development. Both experimental and clinical arguments are sufficient to mind to this problem with great awareness. Therefore, routine repeated measurements of blood glucose concentration are necessary and active intervention is proposed if glucose plasma level decreases below 2.5 mmol/l.
Wayenberg
J-L
JL
Service de pédiatrie, hôpital français, 180 avenue J.-Goffin, 1082 Brussels, Belgium. kl.wayenberg@hopitalfrancais.be
Pardou
A
A
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000254:growth & development*; D001927:Brain Diseases / Q000209:etiology; D002648:Child; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D005609:Free Radicals; D005865:Gestational Age; D006801:Humans; D007003:Hypoglycemia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D008297:Male; D051379:Mice; D011597:Psychomotor Performance; D051381:Rats; D012189:Retrospective Studies; D013552:Swine; D013997:Time Factors
D001786:Blood Glucose; D005609:Free Radicals