[A course of acute respiratory virus infections in patients with metabolic syndrome].
OBJECTIVE
To determine specific features of a course of acute respiratory viral infections (ARVI) and changes in immunological status in patients with metabolic syndrome (MS).


METHODS
Body mass index (BMI), waist circumference, levels of cholesterol, lipoproteins, triglycerides, cytokines and immunoglobulins were measured and glucose tolerance test was made in 120 patients with MS. Registration of ARVI during a year was verified by the presence of antigens in immunofluorescence reaction.


RESULTS
MS patients have obesity of an abdominal type and immunoresistance. Concentration of proinflammatory cytokines and leukocyte count in blood increased proportionally to an increase in fat tissue mass, immunoglobulins content went down. ARVI in most evident MS were characterized by a sluggish and areactive onset, longer course, more frequent respiratory and cardiovascular complications.


CONCLUSIONS
MS is a factor of risk of a sluggish and complicated course of ARVI.
Troshina
I A
IA
Gagina
T A
TA
Petrov
I M
IM
Maleev
V V
VV
Medvedeva
I V
IV
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M