title: Effects of polycystic ovarian syndrome on in vitro fertilization-embryo transfer outcomes are influenced by body mass index.
abstract: OBJECTIVE
  To determine whether polycystic ovary syndrome (PCOS) adversely impacts IVF-embryo transfer outcomes in obese compared to lean patients.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University-affiliated infertility program.
  
  
  METHODS
  Lean non-PCOS (n = 52), lean PCOS (n = 6), obese non-PCOS (n = 18), and obese PCOS (n = 10).
  
  
  METHODS
  Ninety-four fresh nondonor IVF-embryo transfer cycles analyzed.
  
  
  METHODS
  Cycle characteristics, clinical pregnancy (PR) and live birth rates.
  
  
  RESULTS
  Lean PCOS had more dominant follicles (12.2 +/- 6.0 vs. 7.7 +/- 3.6), retrieved oocytes (22.2 +/- 9.2 vs. 12.6 +/- 5.8), and frozen embryos (5 +/- 4.6 vs. 1.4 +/- 2.6) than lean non-PCOS. Lean PCOS also used fewer gonadotropin ampules (18.8 +/- 6.0 vs. 29.2 +/- 14.2), but had more retrieved oocytes (22.2 +/- 9.2 vs.14.3 +/- 4.9) than obese PCOS. Obese non-PCOS had better-grade embryos (2.1 +/- 0.8 vs. 2.7 +/- 0.8) and fewer embryos transferred (2.4 +/- 0.6 vs. 2.9 +/- 0.6) than obese PCOS, but more embryos frozen than lean non-PCOS (3.2 +/- 3.2 vs. 1.4 +/- 2.6). Implantation rates trended downward in obese patients with PCOS, but no other differences were observed.
  
  
  CONCLUSIONS
  Patients with PCOS with a body mass index (BMI) in the lean rather than the obese range have more favorable assisted reproductive technology (ART) cycle characteristics but show no clinical outcome differences.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0526, USA.
authors.forename: Betsy
authors.initials: B
authors.lastname: McCormick
authors.forename: Michael
authors.initials: M
authors.lastname: Thomas
authors.forename: Rose
authors.initials: R
authors.lastname: Maxwell
authors.forename: Daniel
authors.initials: D
authors.lastname: Williams
authors.forename: Mira
authors.initials: M
authors.lastname: Aubuchon
mesh_terms: D000328:Adult; D015992:Body Mass Index; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D054315:Oocyte Retrieval; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome