title: Alternate-day tadalafil in the management of honeymoon impotence.
abstract: BACKGROUND
  Sildenafil has been used successfully in the treatment of honeymoon impotence. However, no study investigated the potential effect of tadalafil in the treatment of honeymoon impotence.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the effectiveness of alternate-day tadalafil therapy in the management of unconsummated marriages.
  
  
  METHODS
  This is a descriptive study comprised of a series of 45 patients. The time frame for the study was 2 years. Forty-five consecutive patients underwent a complete medical and sexual history as well as a focused physical examination. Education about the male and female genital anatomy and the sexual response cycle was carried out. Alternate-day tadalafil 10-mg therapy was administered for 2 weeks with the duration extended as needed.
  
  
  METHODS
  Primary efficacy endpoints were successful vaginal intromission and change in the abridged version of the International Index of Erectile Function (IIEF-5).
  
  
  RESULTS
  Of 45 patients included in our study, 41 (91%) were able to achieve vaginal intromission and perform sexually. Thirty-four patients (76%) needed tadalafil for less than 1 month, five (11%) for up to 3 months, and two (4%) for more than 3 months. Four patients (9%) were unsuccessful. IIEF-5 improved significantly with alternate-day tadalafil treatment in this subgroup of patients (P < 0.001). Treatment failures were managed by intracavernous injection therapy, combined with psychosexual therapy, depending on the cause.
  
  
  CONCLUSIONS
  Tadalafil therapy was safe and effective in the short-term management of this selected group of honeymoon impotence patients. Controlled studies are needed to further confirm these findings.
authors.affiliation: Cairo University-Andrology, Sexology & STDs, Cairo, Egypt.
authors.forename: Hussein
authors.initials: H
authors.lastname: Ghanem
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Dakhly
authors.forename: Rany
authors.initials: R
authors.lastname: Shamloul
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage*; D003075:Coitus; D004334:Drug Administration Schedule; D004534:Egypt; D007172:Erectile Dysfunction / Q000188:drug therapy*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008393:Marriage; D010353:Patient Education as Topic; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage*; D011613:Psychotherapy; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil