title: Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel.
abstract: The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 microg/mL). Three doses elicited a GMC of 59.92 microg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 microg/mL and 67.9% and the sixth of 276.95 microg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.
authors.affiliation: Division of Retrovirology, Walter Reed Army Institute of Research, Military HIV Research Program, Rockville, MD, USA. dsinger@hivresearch.org
authors.forename: Darrell E
authors.initials: DE
authors.lastname: Singer
authors.forename: Rachel
authors.initials: R
authors.lastname: Schneerson
authors.forename: Christian T
authors.initials: CT
authors.lastname: Bautista
authors.forename: Mark V
authors.initials: MV
authors.lastname: Rubertone
authors.forename: John B
authors.initials: JB
authors.lastname: Robbins
authors.forename: David N
authors.initials: DN
authors.lastname: Taylor
mesh_terms: D000293:Adolescent; D000328:Adult; D000881:Anthrax / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001427:Bacterial Toxins / Q000276:immunology*; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D014481:United States; D014611:Vaccination
chemical_list: D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D007074:Immunoglobulin G; C030325:anthrax toxin