MPA: a multiple peak alignment algorithm to perform multiple comparisons of liquid-phase proteomic profiles.
Present proteomic studies increasingly address experimental strategies focused on multiple comparisons of proteomic profiles. To accomplish semiautomatic protein separations based on 2-D LC, the Beckman Coulter PF2D has been developed. Here, we present a novel general purpose tool called MPA (multiple peak alignment) able to perform multiple comparisons of proteomic profiles both in a pairwise guided fashion and in a fully automatic mode using a strategy based on dynamic programing and progressive alignment of time series. The tool is available at http://grup.cribi.unipd.it/people/stefano/mpa/.
Toppo
Stefano
S
Department of Biological Chemistry, University of Padua, via G. Colombo, Padua, Italy. stefano.toppo@unipd.it
Roveri
Antonella
A
Vitale
Maria Pia
MP
Zaccarin
Mattia
M
Serain
Elena
E
Apostolidis
Emanuele
E
Gion
Massimo
M
Maiorino
Matilde
M
Ursini
Fulvio
F
D000465:Algorithms; D002853:Chromatography, Liquid / Q000379:methods*; D019295:Computational Biology; D040901:Proteomics / Q000379:methods*; D012984:Software