title: Metabolic pathways of T-2 toxin.
abstract: Among the naturally-occurring trichothecenes found in food and feed, T-2 toxin is the most potent and toxic mycotoxin. After ingestion of T-2 toxin into the organism, it is processed and eliminated. Some metabolites of this trichothecene are equally toxic or slightly more toxic than T-2 itself, and therefore, the metabolic fate of T-2 toxin has been of great concern. The main reactions in trichothecene metabolism are hydrolysis, hydroxylation and deep oxidation. Typical metabolites of T-2 toxin in an organism are HT-2 toxin, T-2-triol, T-2-tetraol, 3'-hydroxy-T-2, and 3'-hydroxy-HT-2 toxin. There are significant differences in the metabolic pathways of T-2 toxin between ruminants and non-ruminants. Ruminants have been more resistant to the adverse effects of T-2 toxin due to microbial degradation within rumen microorganisms. Some plant species are resistant to T-2 toxin, while others are capable of its intake and metabolisation.
authors.affiliation: Department of Toxicology, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic. dohnal@mendelu.cz
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Dohnal
authors.forename: Alena
authors.initials: A
authors.lastname: Jezkova
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001711:Biotransformation; D005618:Fresh Water / Q000382:microbiology; D005658:Fungi / Q000378:metabolism; D006868:Hydrolysis; D006900:Hydroxylation; D010084:Oxidation-Reduction; D010944:Plants / Q000378:metabolism; D012417:Rumen / Q000378:metabolism / Q000382:microbiology; D012988:Soil Microbiology; D013605:T-2 Toxin / Q000378:metabolism*
chemical_list: D013605:T-2 Toxin