A highly stereoselective synthesis of the C10-C23 fragment of (-)-dictyostatin.
A highly stereoselective synthesis of the C10-C23 fragment of (-)-dictyostatin has been achieved using a Carreira alkynylation and a Marshall-Tamaru allenylzinc addition as key steps.
Monti
Chiara
C
Dipartimento di Chimica Organica e Industriale, Centro di Eccellenza C.I.S.I., Università degli Studi di Milano, Via G. Venezian, 21, 20133 Milano, Italy.
Sharon
Ofer
O
Gennari
Cesare
C
D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
D018942:Macrolides; C470814:dictyostatin