Redox based anti-oxidant systems in plants: biochemical and structural analyses.
We provide in this paper a comparative biochemical and structural analysis of the major thiol oxidoreductases (thioredoxin and glutaredoxin) of photosynthetic organisms in relation with their reductases and with target proteins, especially those involved either in the detoxication of peroxides such as hydrogen peroxide (thiol-peroxidases) or in the repair of oxidized methionines in proteins (methionine sulfoxide reductases). Particular emphasis will be given to the catalytic and regeneration mechanisms used by these enzymes. In addition, the protein-protein interactions of these systems will be discussed, leading to an integrated view of the functioning of these systems in various plant sub-cellular compartments.
Rouhier
Nicolas
N
Unité Mixte de Recherches 1136 Interaction Arbres Microorganismes, IFR 110 GEEF, Nancy University, Faculté des Sciences 54506 Vandoeuvre-lès-Nancy, Cedex, France.
Koh
Cha San
CS
Gelhaye
Eric
E
Corbier
Catherine
C
Favier
Frédérique
F
Didierjean
Claude
C
Jacquot
Jean-Pierre
JP
D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000201:enzymology / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D010940:Plant Proteins; D013438:Sulfhydryl Compounds; D010544:Peroxidases