An efficient silane-promoted nickel-catalyzed amination of aryl and heteroaryl chlorides.
A new silane-promoted nickel-catalyzed amination of aryl chlorides with 0.5 mol % of Ni(acac)2, 1 mol % of 3,5,6,8-tetrabromo-1,10-phenanthroline, and polymethylhydrosiloxane was developed. A broad range of aryl and heteroaryl chlorides can be coupled with secondary amines and anilines to give the desired (het)arylamines in good to excellent yields. The reaction is sensitive to the nature and amount of the silane promoter.
Manolikakes
Georg
G
Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich, Germany.
Gavryushin
Andrei
A
Knochel
Paul
P
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009532:Nickel / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000588:Amines; D002712:Chlorides; D012821:Silanes; D009532:Nickel