title: Human herpesvirus 7 primary infection in kidney transplant recipients.
abstract: The aims of the study were to evaluate the incidence and the clinical implications of human herpesvirus (HHV)-7 primary infection in patients undergoing kidney transplantation and the probable interactions between the three beta-herpesviruses (cytomegalovirus [CMV], HHV-6, and HHV-7). Sixty kidney transplant recipients had sequential plasma and whole blood samples collected prior to transplantation and at 7, 14, 21, 28, 45, 60, 75, 90, and 180 days posttransplantation. We used indirect immunofluorescence assays to detect HHV-7 immunoglobulin (Ig) G antibodies in plasma and quantitative real-time polymerase chain reaction to assess CMV, HHV-6 and HHV-7 viral loads. Sixteen out of 60 patients (27%) did not show HHV-7 IgG antibodies prior to transplantation and they were selected for this study. Whereas 3 (18.75%) out of the 16 HHV-7 seronegative patients seroconverted after transplantation, only one patient (6%) had a high HHV-7 viral load from the seventh day posttransplantation in consecutive blood samples during follow-up without clinical manifestations. In our study, the incidence of posttransplant HHV-7 primary infection was low and asymptomatic.
authors.affiliation: Department of Microbiology, Hospital Clínic (Barcelona), IDIBAPS, University of Barcelona, Barcelona, Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Antón
authors.forename: Carlos
authors.initials: C
authors.lastname: Cervera
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: Asunción
authors.initials: A
authors.lastname: Moreno
authors.forename: Natividad
authors.initials: N
authors.lastname: Benito
authors.forename: Laura
authors.initials: L
authors.lastname: Linares
authors.forename: Cristina
authors.initials: C
authors.lastname: Esteva
authors.forename: Federico
authors.initials: F
authors.lastname: Cofán
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Jiménez de Anta
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Marcos
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood; D005500:Follow-Up Studies; D016199:Herpesvirus 7, Human; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications / Q000453:epidemiology / Q000821:virology*; D011446:Prospective Studies; D019349:Roseolovirus Infections / Q000453:epidemiology*; D013030:Spain; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G