Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator).
BACKGROUND
There are no published guidelines for use of real-time continuous glucose monitoring data by a patient; we therefore developed the DirecNet Applied Treatment Algorithm (DATA). The DATA provides algorithms for making diabetes management decisions using glucose values: (i) in real time which include the direction and rate of change of glucose levels, and (ii) retrospectively based on downloaded sensor data.


OBJECTIVE
To evaluate the use and effectiveness of the DATA in children with diabetes using a real-time continuous glucose sensor (the FreeStyle Navigator).


METHODS
Thirty children and adolescents (mean +/- standard deviation age = 11.2 +/- 4.1 yr) receiving insulin pump therapy.


METHODS
Subjects were instructed on use of the DATA and were asked to download their Navigator weekly to review glucose patterns. An Algorithm Satisfaction Questionnaire was completed at 3, 7, and 13 wk.


RESULTS
At 13 wk, all of the subjects and all but one parent thought that the DATA gave good, clear directions for insulin dosing, and thought the guidelines improved their postprandial glucose levels. In responding to alarms, 86% of patients used the DATA at least 50% of the time at 3 wk, and 59% reported doing so at 13 wk. Similar results were seen in using the DATA to adjust premeal bolus doses of insulin.


CONCLUSIONS
These results show the feasibility of implementing the DATA when real-time continuous glucose monitoring is initiated and support its use in future clinical trials of real-time continuous glucose monitoring.
Buckingham
Bruce
B
Xing
Dongyuan
D
Weinzimer
Stu
S
Fiallo-Scharer
Rosanna
R
Kollman
Craig
C
Mauras
Nelly
N
Tsalikian
Eva
E
Tamborlane
William
W
Wysocki
Tim
T
Ruedy
Katrina
K
Beck
Roy
R
D000293:Adolescent; D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D002648:Child; D003199:Computer Systems; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D005240:Feasibility Studies; D006801:Humans; D007332:Insulin Infusion Systems; D018670:Monitoring, Ambulatory / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods*; D017060:Patient Satisfaction
D001786:Blood Glucose