The synthesis and biological evaluation of a range of novel functionalized benzopyrans as potential potassium channel activators.
A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.
Tyrrell
Elizabeth
E
School of Pharmacy & Chemistry, Kingston University, Penrhyn Road, Kingston, Surrey KT1 2EE, UK. e.tyrrell@kingston.ac.uk
Tesfa
Kibur Hunie
KH
Greenwood
Iain
I
Mann
Alistair
A
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D019806:Cromakalim / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009126:Muscle Relaxation / Q000187:drug effects; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D001578:Benzopyrans; D015221:Potassium Channels; D019806:Cromakalim