Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features.
BACKGROUND
To retrospectively analyze computed tomography (CT) features of adenosquamous carcinoma (ASC) of the extrahepatic bile duct and to correlate them with pathologic findings.


METHODS
Six patients who underwent radical surgical resection for ASC of extrahepatic bile duct were included. CT and pathologic findings were analyzed and correlated with each other.


RESULTS
Five ASCs were periductal infiltrative type and the remaining one was intraductal polypoid type. Histologically, ASC was composed of squamous and glandular components which mixed in an intermingled pattern and was characterized by a high local aggressiveness mainly due to the squamous component. The most common CT findings were a segmental wall thickening with delayed enhancement. Overall, CT features were well correlated with pathologic findings. However, CT tended to underestimate radial extent of the tumor compared with histologic findings.


CONCLUSIONS
Histopathologically, ASC of the extrahepatic bile duct is characterized by greater local aggressiveness. However, their CT findings are not quite different from those of usual adenocarcinoma due to the unique geographic characteristic of being located at a very limited space.
Kim
Kyung Won
KW
Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, 28 Yeongon-dong, Jongno-gu, Seoul, 110-744, Korea.
Kim
Se Hyung
SH
Kim
Min A
MA
Lee
Jeong Min
JM
Park
Hee Sun
HS
Kim
Ji Young
JY
Lee
Jae Young
JY
Han
Joon Koo
JK
Choi
Byung Ihn
BI
D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D017734:Bile Ducts, Extrahepatic; D018196:Carcinoma, Adenosquamous / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D002758:Cholangiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed