title: [Systemic neurolymphomatosis complicated in diffuse large B-cell lymphoma].
abstract: A 73-year-old woman was diagnosed with diffuse large B-cell lymphoma of the uterus (Stage IVB). After 3 courses of CHOP therapy, right abducens nerve paralysis appeared and was diagnosed as central nervous system infiltration with lymphoma cells. Although partial remission was obtained by chemotherapy with methotrexate, numbness and muscle weakness of all four limbs appeared asymmetrically and progressed subacutely. Nerve conduction velocity examination revealed mononeuritis multiplex, but we could not reach a final diagnosis. Steroid pulse therapy, chemotherapy including high-dose methotrexate, and radiation therapy were ineffective. On autopsy, histological examination of the peripheral nerves revealed systemic neurolymphomatosis.
authors.affiliation: Department of Hematology, Shizuoka Red Cross Hospital.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ueda
authors.forename: Jun
authors.initials: J
authors.lastname: Katoh
authors.forename: Sachiya
authors.initials: S
authors.lastname: Takemura
authors.forename: Jun
authors.initials: J
authors.lastname: Taguchi
authors.forename: Yoji
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Kasahara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujita
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D009420:Nervous System / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*