title: Actinomyces--gathering evidence of human colonization and infection.
abstract: The roles of the 'classical'Actinomyces spp. as colonizers of oral cavities of man and animals, in development of intra-oral infections and as agents of actinomycosis have been well documented. This mini-review focuses on perceptions of human colonization and infection that have emerged in the past decade, largely as a result of advances in classification, identification and direct detection from clinical material. Arguably, of the greatest importance is the recognition of actinomycosis as a major factor and indicator of poor prognosis in both infected osteoradionecrosis and bisphosphonate-associated osteonecrosis of the jaws. Among recently described species, Actinomyces graevenitzii has been isolated almost exclusively from oral and respiratory sites and may be a causative agent of actinomycosis. Conversely, several other Actinomyces spp. are isolated commonly from superficial soft tissue infections. Members of the genus Actinobaculum, which is closely related to Actinomyces, are strongly associated with urosepsis. Isolation and identification of Actinomyces and related genera by conventional methods remain difficult. Diagnosis is commonly belated and based solely upon histological findings. Development of direct detection methods may aid patient management and further elucidate clinical associations.
authors.affiliation: Anaerobe Reference Unit, NPHS Microbiology Cardiff, University Hospital of Wales, Cardiff CF14 4XW, UK. val.hall@nphs.wales.nhs.uk
authors.forename: Val
authors.initials: V
authors.lastname: Hall
mesh_terms: D000190:Actinomyces / Q000145:classification / Q000254:growth & development* / Q000302:isolation & purification*; D000196:Actinomycosis / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D007571:Jaw Diseases / Q000175:diagnosis / Q000382:microbiology; D009055:Mouth / Q000382:microbiology*; D010025:Osteoradionecrosis / Q000175:diagnosis / Q000382:microbiology*