title: Subversion of myosin function by E. coli.
abstract: Enteropathogenic E. coli establish close contact with host cells by nucleating localized actin rearrangements and directly evading phagocytosis. Iizumi et al. now show in a recent issue of Cell Host and Microbe that the type III secretion effector EspB, initially thought to be involved in the translocation of other bacterial effectors, mediates antiphagocytosis and microvilli lesions by inhibiting myosin function.
authors.affiliation: The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0721, USA.
authors.forename: Seema
authors.initials: S
authors.lastname: Mattoo
authors.forename: Neal M
authors.initials: NM
authors.lastname: Alto
authors.forename: Jack E
authors.initials: JE
authors.lastname: Dixon
mesh_terms: D003599:Cytoskeleton / Q000502:physiology; D054308:Enteropathogenic Escherichia coli / Q000502:physiology*; D004927:Escherichia coli Infections / Q000503:physiopathology*; D006801:Humans; D009218:Myosins / Q000737:chemistry* / Q000502:physiology; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D009218:Myosins