Preserved heart rate variability in first-degree relatives of subjects with Type 2 diabetes mellitus without metabolic disorders.
OBJECTIVE
To investigate the influence of a family history of Type 2 diabetes mellitus (T2DM) on resting heart rate variability in the absence of concomitant metabolic disorders.


METHODS
We studied 55 first-degree relatives (FDRs) of subjects with T2DM and 36 control subjects without any known family history of diabetes. FDRs were recruited from a University Hospital out-patient diabetes clinic. The protocol included: oral glucose tolerance test (30, 60, 90 and 120 min after ingestion of 75 g glucose) blood glucose, plasma insulin, cholesterol and subfractions, triglycerides, leptin and C-reactive protein. Heart rate variability (HRV) at rest was determined by spectral analysis of interbeat intervals recorded during 10 min in the supine position.


RESULTS
HRV was lower in FDRs compared with control subjects (P < 0.05). Multiple regression analysis identified cholesterol (P = 0.014) and triglycerides (P = 0.014) as significant independent predictors (model r = 0.40; P < 0.001) of HRV. Since FDRs had higher values for anthropometric and metabolic variables known to alter HRV, we performed an ancova adjusted for cholesterol and triglycerides and also another analysis in which the groups were comparable for anthropometric and metabolic characteristics. Comparison of FDRs and comparable control subjects revealed no significant difference in HRV (P > 0.05).


CONCLUSIONS
A family history of T2DM, in the absence of concomitant metabolic disorders, does not impair heart rate variability.
Neves
F J
FJ
Department of Physiology and Pharmacology & Postgraduate Programme in Cardiovascular Sciences, Federal Fluminense University, Niterói, Rio de Janeiro, RJ, Brazil.
Bousquet-Santos
K
K
Silva
B M
BM
Soares
P P S
PP
Nóbrega
A C L
AC
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D004812:Epidemiologic Methods; D005080:Exercise Test / Q000379:methods*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006339:Heart Rate / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics; D010375:Pedigree