Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.
Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene-encoding retinoic acid receptor alpha (RARA) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta (STAT5B) is one of the alternative partners. We report a rare case of APL with STAT5B-RARA fusion transcript and the normal chromosome 17 on G-banding. Administration of all trans-retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. The molecular mechanism of fusion between STAT5B and RARA by chromosomal rearrangement is discussed based on the data from genome database. Clinical characteristics of APL with STAT5B-RARA are also discussed.
Kusakabe
Manabu
M
Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Suzukawa
Kazumi
K
Nanmoku
Toru
T
Obara
Naoshi
N
Okoshi
Yasushi
Y
Mukai
Harumi Y
HY
Hasegawa
Yuichi
Y
Kojima
Hiroshi
H
Kawakami
Yasushi
Y
Ninomiya
Haruhiko
H
Nagasawa
Toshiro
T
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000032:analysis* / Q000737:chemistry / Q000235:genetics*; D050799:STAT5 Transcription Factor / Q000032:analysis* / Q000737:chemistry / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
D015514:Oncogene Proteins, Fusion; D050799:STAT5 Transcription Factor; C456500:STAT5-RARalpha protein, human