Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1.
Kuch
David
D
Center for Integrated Protein Science (CiPSM), Department of Chemistry and Biochemistry, LMU Munich, Butenandtstrasse 5-13, 81377 Munich, Germany.
Schermelleh
Lothar
L
Manetto
Susanne
S
Leonhardt
Heinrich
H
Carell
Thomas
T
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D032446:Myoblasts / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization
D004791:Enzyme Inhibitors; D004247:DNA; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619380:DNMT1 protein, human; C000619381:Dnmt1 protein, mouse