[Signal transduction mechanisms of steroid hormone receptors].
The multiple physiological effects of steroid hormones are mediated by the cognate nuclear receptors through transcriptional regulation of target gene expression. Recently, post-transcriptional modifications of steroid receptors and cross-talk between steroid hormone signaling with other signaling pathways have been found to play a pivotal role in cell- and gene-specific transcriptional regulation. This is a brief overview on the role of interaction with different transcriptional factors and specific post-translational modifications (phosphorylation, acetylation and ubiquitination) of nuclear receptors in defining the physiological outcome of steroid hormone action.
Takeyama
Ken-ichi
K
Institute of Molecular and Cellular Biosciences, University of Tokyo.
Kato
Shigeaki
S
D006801:Humans; D011499:Protein Processing, Post-Translational / Q000502:physiology; D020239:Receptor Cross-Talk / Q000502:physiology; D011987:Receptors, Steroid / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011987:Receptors, Steroid