[Five cases of pseudomyxoma peritonei underwent abdominal lavage and administering CDDP].
We examined five cases of pseudomyxoma peritonei with treatments of cytoreduction surgery, abdominal lavage and intraperiotoneal administration of cisplatin (CDDP). These primary lesions contained one case of pancreas and four cases of appendix. Histological types contained one case of well differentiated adenocarcinoma and four cases of signet ring cell carcinoma. All cases underwent a resection of primary lesion and muconodule, abdominal lavage with saline and 5% glucose or low molecule dextran solution. CDDP was administered into the abdominal space during and after the surgery, a total amount of 100 to 400 mg/body. There were no cases of collected ascites within one year, except one case that we could not follow. There was a possibility that a short-term quality of life was improved by multidiciplinary therapy containing cytoreduction surgery and intraperiotoneal administration of CDDP.
Okada
Norimichi
N
Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
Ishibashi
Kichiro
K
Nakada
Hiroshi
H
Miyazaki
Tatsuya
T
Sobajima
Jun
J
Gonda
Tsuyoshi
T
Ishida
Hideyuki
H
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010533:Peritoneal Lavage; D011379:Prognosis; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery
D002945:Cisplatin