Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a "magic bullet" drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
Van der Schyf
Cornelis J
CJ
Department of Pharmaceutical Science, Northwestern Ohio Universities College of Pharmacy, Rootstown, OH 44272, USA.
Mandel
Silvia
S
Geldenhuys
Werner J
WJ
Amit
Tamar
T
Avramovich
Yael
Y
Zheng
Hailin
H
Fridkin
Mati
M
Gal
Shunit
S
Weinreb
Orly
O
Bar Am
Orit
O
Sagi
Yotam
Y
Youdim
Moussa B H
MB
D000544:Alzheimer Disease / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D002490:Central Nervous System / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism*
D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents