title: [A case of successfully treated sigmoid colon cancer with multiple regional metastases by chemotherapy and radiation therapy].
abstract: Multiple regional metastases due to colon cancer usually show poor prognosis. Various treatments such as chemotherapy and radiation therapy are not sufficient, and the outcome is generally poor in many cases. We report here on a patient with multiple regional metastases who was successfully treated with several therapies and remains still alive. A 69-year-old man presented with fever and epigastralgia. A colonoscopy revealed primary sigmoid colon cancer. A computed tomography showed multiple hepatic metastases, and metastases to supraclavicular, mediastinal and para-aortic regional lymph nodes. The bone metastases were detected by scintigram. He was treated with combination chemotherapy of 5-FU via hepatic artery and CPT-11 by systemic administration. The primary tumor had completely disappeared (complete response), and metastases to liver and lymph nodes showed a remarkable shrinkage (partial response) after the chemotherapy. In contrast, bone metastases showed progressive growth (progressive disease). Radiation therapy and bisphosphonate infusion for bone metastases were achieved, and the treatments have controlled the growth of the metastases. Primary tumors and metastases are still controlled well for 3 years after the initial chemotherapy.
authors.affiliation: Dept. of Surgery, NTT West Osaka Hospital.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kanoh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tono
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kira
authors.forename: Hiroumi
authors.initials: H
authors.lastname: Nagase
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Ken
authors.initials: K
authors.lastname: Shiozaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwazawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
authors.forename: Takushi
authors.initials: T
authors.lastname: Monden
mesh_terms: D000368:Aged; D003113:Colonoscopy; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D012811:Sigmoid Neoplasms / Q000145:classification / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed