title: Surgical outcome of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis.
abstract: Seizure outcome in mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) that was evaluated according to a noninvasive protocol was assessed in 165 patients and reported using both Engel's and ILAE classifications. The mean postoperative follow-up was 5.0 +/- 2.7 years. At the end of first year, 77.1% of patients were in Engel-I, and 52.7% were in ILAE-I. Antiepileptic drugs (AEDs) were discontinued in 41 patients (42.7%), all remained seizure-free for >or= 2 years that could be accepted as "cure." Thirty-six patients had recurrences, 19 had running-down phenomena. Anterior temporal lobectomy (ATL) was performed in 27 patients with a better outcome when compared to patients operated by selective anterior hippocampectomy. Clinical risk factors for better and worse outcome, which show some similarity in different reports, seem to veil the main reason, which is the accurate delineation of epileptogenic zone considering the presence of different subgroups and underlying developmental pathologies.
authors.affiliation: Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. cigdemoz@istanbul.edu.tr
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Ozkara
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uzan
authors.forename: Gülçin
authors.initials: G
authors.lastname: Benbir
authors.forename: Naz
authors.initials: N
authors.lastname: Yeni
authors.forename: Büge
authors.initials: B
authors.lastname: Oz
authors.forename: Lütfü
authors.initials: L
authors.lastname: Hanoğlu
authors.forename: Naci
authors.initials: N
authors.lastname: Karaağac
authors.forename: Emin
authors.initials: E
authors.lastname: Ozyurt
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D038481:Anterior Temporal Lobectomy; D002648:Child; D018572:Disease-Free Survival; D004833:Epilepsy, Temporal Lobe / Q000145:classification / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D012598:Sclerosis / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome