title: Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: a case report.
abstract: Case history The two obese mandrills (Mandrillus sphinx) showed clinical signs of depression, anorexia, hyperglycemia, hypertriglyceridemia, glucosuria, proteinuria and ketonuria. Septic bed sore wounds were noted on both fore and hind limbs. Results Histopathological study revealed severe islet amyloidosis in both mandrills. Immunohistochemical study using polyclonal anti-cat amylin antibody confirmed derivation of the islet amyloid from islet amyloid polypeptide (IAPP). Cardiomyopathy and myocardial fibrosis were also evident. Conclusions The present study documents diabetes mellitus in two obese mandrills. Diabetes in these animals had features very similar type 2 diabetes mellitus of humans, including the development of severe, IAPP-derived islet amyloidosis. The mandrill may, therefore, serve as an animal model of human type 2 diabetes mellitus.
authors.affiliation: Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: N
authors.initials: N
authors.lastname: Pirarat
authors.forename: S
authors.initials: S
authors.lastname: Kesdangsakolwut
authors.forename: S
authors.initials: S
authors.lastname: Chotiapisitkul
authors.forename: S
authors.initials: S
authors.lastname: Assarasakorn
mesh_terms: D000682:Amyloid; D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D048528:Mandrillus; D008992:Monkey Diseases / Q000473:pathology*; D009765:Obesity / Q000150:complications; D010179:Pancreas / Q000473:pathology
chemical_list: D000682:Amyloid