title: Poly (3,4-ethylenedioxythiophene) for chronic neural stimulation.
abstract: Chronic neural stimulation using microelectrode arrays requires highly stable and biocompatible electrode materials with high charge injection capability. Conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was electrochemically deposited on thin film Pt electrodes of stimulation electrode arrays to evaluate its properties for chronic stimulation. The coated electrodes demonstrated much lower impedance than thin film Pt due to the high surface area and high ion conductivity across the film. The PEDOT film also presents intrinsic redox activity which contributes to the low impedance as well as a much higher charge storage capacity. The charge injection limit of PEDOT electrode was found to be 2.3 mC/cm2, comparable to IrOx and much higher than thin film Pt. Under biphasic stimulation, the coated electrodes exhibited lower voltage and linear voltage excursion. Well-coated PEDOT electrodes were stable under chronic stimulation conditions, suggesting that PEDOT is a promising electrode material to be further developed for chronic neural stimulation applications.
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA. xic11@pitt.edu
authors.forename: Xinyan Tracy
authors.initials: XT
authors.lastname: Cui
authors.forename: David Daomin
authors.initials: DD
authors.lastname: Zhou
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D017097:Electric Impedance; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D006801:Humans; D009424:Nervous System Physiological Phenomena; D010084:Oxidation-Reduction; D010984:Platinum; D011108:Polymers / Q000737:chemistry; D012997:Solvents; D013499:Surface Properties
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; D012997:Solvents; C121383:poly(3,4-ethylene dioxythiophene); D010984:Platinum