title: Irreversible sensorineural hearing loss due to Imatinib.
abstract: OBJECTIVE
  We report probably the first case of bilateral irreversible sensorineural hearing loss caused by Imatinib.
  
  
  METHODS
  A review of the world literature, concerning Imatinib toxicity is presented.
  
  
  RESULTS
  We report a case of bilateral irreversible sensorineural hearing loss, in a 19-year-old male patient of chronic myeloid leukemia after 3 months of Imatinib therapy. Audiometric evaluation documented the findings.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case report of Imatinib induced sensorineural hearing loss. This case indicates that treating oncologists should keep in mind that this drug too can produce ototoxicity.
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India. sureshattili@yahoo.com
authors.forename: Venkata Satya Suresh
authors.initials: VS
authors.lastname: Attili
authors.forename: P P
authors.initials: PP
authors.lastname: Bapsy
authors.forename: G
authors.initials: G
authors.lastname: Anupama
authors.forename: D
authors.initials: D
authors.lastname: Lokanatha
mesh_terms: D000328:Adult; D001549:Benzamides; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D000068877:Imatinib Mesylate; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy; D008297:Male; D010879:Piperazines / Q000009:adverse effects*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000009:adverse effects*
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases