title: Pd-P(t-Bu)(3)-catalyzed consecutive cross-coupling of p-phenylenedizinc compound with two different electrophiles leading to unsymmetrically 1,4-disubstituted benzenes.
abstract: Pd-P(t-Bu)3 was found to be a chemoselective catalyst for the reaction of p-phenylenedizinc compound with equimolar amounts of carbon electrophiles to afford the single cross-coupling products in good yields, effectively suppressing the formation of double cross-coupling products. The subsequent additions of other electrophiles to the resulting solutions caused the second cross-coupling of the incipient products to take place, achieving a novel and efficient one-pot synthesis of unsymmetrically 1,4-disubstituted benzenes. The origin of the observed high chemoselectivity was speculated.
authors.affiliation: Department of Chemistry, Faculty of Science, Okayama University, Tsushima, Okayama 700-8530, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Shogo
authors.initials: S
authors.lastname: Ejiri
authors.forename: Kana
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Odo
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nishihara
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi