[Idiopathic pulmonary hemosiderosis treated with azathioprine in a child].
Idiopathic pulmonary hemosiderosis (IPH), the main cause of pulmonary hemosiderosis in children, is characterized by intermittent alveolar bleeding and hemosiderin-laden macrophages in sputum and in gastric lavage. The treatment is based on corticosteroids and cytotoxic drugs, under special conditions. We describe the case of a 7-year-old girl with IPH who achieved partial clinical remission with high doses of corticosteroids. However, the treatment had to be discontinued because the patient developed Cushing's syndrome. Treatment was started with an azathioprine-corticosteroid combination and then changed to azathioprine alone, which was maintained for four years, with excellent results.
Sant'Anna
Clemax Couto
CC
Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. clemax@vetor.com.br
Horta
Angélica Almada
AA
Tura
Mônica Tessinari Rangel
MT
March
Maria de Fatima Bazhuni Pombo
Mde F
Ferreira
Sidnei
S
Aurilio
Rafaela Baroni
RB
Vieira
Débora Brandão
DB
D001379:Azathioprine / Q000008:administration & dosage*; D002648:Child; D003480:Cushing Syndrome / Q000209:etiology; D005260:Female; D006486:Hemosiderosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography
D007166:Immunosuppressive Agents; D001379:Azathioprine