Vascular versus myocardial dysfunction in acute coronary syndrome: are the adhesion molecules as powerful as NT-proBNP for long-term risk stratification?
OBJECTIVE
To determine if elevations of adhesion molecules in acute coronary syndrome (ACS) are useful for risk stratification.


METHODS
A cell adhesion array (Randox Ltd.) and NT-proBNP were measured in 216 ACS patients.


RESULTS
Kaplan-Meier and Cox models indicate early elevations of NT-proBNP but not the adhesion molecules are predictive of future death/myocardial infarction.


CONCLUSIONS
Elevations of adhesion molecules early after pain onset in ACS are not useful for long-term risk stratification.
Kavsak
Peter A
PA
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. kavsakp@mcmaster.ca
Ko
Dennis T
DT
Newman
Alice M
AM
Lustig
Viliam
V
Palomaki
Glenn E
GE
MacRae
Andrew R
AR
Jaffe
Allan S
AS
D054058:Acute Coronary Syndrome / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D046228:Microarray Analysis / Q000379:methods; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011498:Protein Precursors / Q000378:metabolism*; D012307:Risk Factors; D020107:Troponin T / Q000378:metabolism
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D010446:Peptide Fragments; D011498:Protein Precursors; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain