title: [The vacuum-assisted closure (V.A.C.) and instillation dressing: limb salvage after 3 degrees open fracture with massive bone and soft tissue defect and superinfection].
abstract: We report the case of a 17-year-old boy who was hit by a high velocity train. The polytraumatized patient suffered a 3 degrees open femur defect fracture with a substantial loss of the lateral femoral muscles and significant disruption of the soft tissue of the lower leg. The enormous wound areas on the thigh and the lower leg were infected by Pseudomonas aeruginosa, Enterobacter cloacae, and Stenotrophomonas maltophilia. The enormous tissue defects and the superinfection did not leave any hope for saving the limb from amputation. After rapid aggressive debridement and pulsatile lavage, we covered the wounds as a last resort with a new technique of vacuum-assisted closure (V.A.C) and instillation (V.A.C. Instill(R)) dressings. In sequences of 1 min we instilled Lavasept, kept it for 20 min on the wound surface, and exhausted the liquid. We repeated this for 6 consecutive days and then changed the dressing. In the follow-up examinations the number of germs was significantly reduced. During follow-up care we used the V.A.C. treatment without instillation and finally we transplanted skin onto the clean wound surface and were able to save the leg of this young patient. We discharged him with a good function of his lower leg. This technique of V.A.C. Instill seems to offer great possibilities in critically infected wound situations.
authors.affiliation: Abteilung für Unfallchirurgie, Chirurgische Klinik, Universitätsklinikum, Krankenhausstrasse 12, 91054 Erlangen, Deutschland. matthias.brem@chir.imed.uni-erlangen.de
authors.forename: M H
authors.initials: MH
authors.lastname: Brem
authors.forename: M
authors.initials: M
authors.lastname: Blanke
authors.forename: A
authors.initials: A
authors.lastname: Olk
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
authors.forename: O
authors.initials: O
authors.lastname: Mueller
authors.forename: F F
authors.initials: FF
authors.lastname: Hennig
authors.forename: J
authors.initials: J
authors.lastname: Gusinde
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D001645:Biguanides / Q000008:administration & dosage; D003646:Debridement; D016972:Enterobacter cloacae; D004756:Enterobacteriaceae Infections / Q000601:surgery; D005264:Femoral Fractures / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary; D017102:Fracture Healing / Q000502:physiology; D005597:Fractures, Open / Q000601:surgery*; D016905:Gram-Negative Bacterial Infections / Q000601:surgery; D006801:Humans; D007869:Leg Injuries / Q000601:surgery*; D023821:Limb Salvage; D008297:Male; D009104:Multiple Trauma / Q000601:surgery; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D011552:Pseudomonas Infections / Q000601:surgery; D017695:Soft Tissue Injuries / Q000601:surgery*; D020588:Stenotrophomonas; D013396:Suction; D015163:Superinfection / Q000601:surgery*
chemical_list: D001645:Biguanides; C031233:polihexanide