A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2.
The non-classical human leucocyte antigen (HLA) class I locus, HLA-G, shows a low protein polymorphism and a more varied DNA (eight proteins and 28 alleles). HLA-G DNA polymorphism accounts mainly for changes at third codon bases of the protein coding exons; this does not imply amino acid change in most cases. This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G.
Arnaiz-Villena
A
A
Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain. aarnaiz@med.ucm.es
Serrano-Vela
J I
JI
Reguera
R
R
Perez-Saborido
B
B
Moreno
E
E
Moscoso
J
J
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005091:Exons; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D009626:Terminology as Topic
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D004247:DNA