Mitochondrial injury in pancreatitis.
Pancreatitis is an increasingly common disease that carries a significant mortality and which lacks specific therapy. Pathological calcium signalling is an important contributor to the initiating cell injury, caused by or acting through mitochondrial inhibition. A principal effect of disordered cell signalling and impaired mitochondrial function is cell death, either by apoptosis that is primarily protective, or by necrosis that is deleterious, both locally and systemically. Mitochondrial calcium overload is particularly important in necrotic injury, which may include damage mediated by the mitochondrial permeability transition pore. The role of reactive oxygen species remains controversial. Present understanding of the part played by disordered pancreatic acinar calcium signalling and mitochondrial inhibition offers several new potential therapeutic targets.
Mukherjee
R
R
Division of Surgery and Oncology, University of Liverpool, Royal Liverpool University Hospital, Daulby Street, Liverpool, United Kingdom.
Criddle
D N
DN
Gukovskaya
A
A
Gukvoskaya
A
A
Pandol
S
S
Petersen
O H
OH
Sutton
R
R
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D020013:Calcium Signaling / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology; D000083162:Mitochondrial Permeability Transition Pore; D018384:Oxidative Stress / Q000502:physiology; D010179:Pancreas / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D010195:Pancreatitis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D017382:Reactive Oxygen Species / Q000009:adverse effects
D000975:Antioxidants; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species; D020169:Caspases