Lack of association of the dopamine transporter gene in a French ADHD sample.
Discrepancies in the role of the 40 bp VNTR polymorphism of the dopamine transporter gene (DAT1) in attention-deficit hyperactivity disorder (ADHD) could be due to various sources of genetic or phenotypical heterogeneity. We therefore analyzed a sample of 146 ADHD children and their parents, with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale, the number of errors and the total score at Stroop Color-Word test, and the total score at the Trail Making Test. The TDT for 10-repeat (10-R) allele shows a perfect lack of transmission bias (Mc Nemar chi(2) = 0) and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio (number of transmitted versus untransmitted 10-R allele) of 1.00 exactly, this possibility may be considered as not very likely.
Wohl
M
M
INSERM U 675, University Xavier Bichat (IFR02), Paris, France.
Boni
C
C
Asch
M
M
Cortese
S
S
Orejarena
S
S
Mouren
M C
MC
Gorwood
P
P
Purper-Ouakil
D
D
D000293:Adolescent; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D016001:Confidence Intervals; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D009035:Mothers / Q000706:statistics & numerical data; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human