title: Insulin-like growth factor axis and oncogenic human papillomavirus natural history.
abstract: High serum levels of insulin-like growth factor-I (IGF-I) are reported to be a risk factor for several common cancers, and recent cross-sectional data suggest a possible additional association of IGF-I with cervical neoplasia. To prospectively assess whether circulating IGF-I levels influence the natural history of oncogenic human papillomavirus (HPV), the viral cause of cervical cancer, we conducted a pilot investigation of 137 women who underwent semiannual type-specific HPV DNA PCR testing and cervical cytology. Total IGF-I and IGF binding protein-3 (IGFBP-3), the most abundant IGFBP in circulation, were measured using baseline serum specimens. Having a high IGF-I/IGFBP-3 ratio was associated with increased persistence of oncogenic HPV infection [that is, a lower rate of clearance; adjusted hazard ratio (AHR), 0.14; 95% confidence interval (95% CI), 0.04-0.57], whereas IGFBP-3 was inversely associated with both the incident detection of oncogenic HPV (AHR, 0.35; 95% CI, 0.13-0.93) and the incidence of oncogenic HPV-positive cervical neoplasia (that is, squamous intraepithelial lesions at risk of progression; AHR, 0.07; 95% CI, 0.01-0.66). These prospective data provide initial evidence that the IGF axis may influence the natural history of oncogenic HPV.
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Tiffany G
authors.initials: TG
authors.lastname: Harris
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burk
authors.forename: Herbert
authors.initials: H
authors.lastname: Yu
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
authors.forename: L Stewart
authors.initials: LS
authors.lastname: Massad
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhong
authors.forename: Stephen
authors.initials: S
authors.lastname: Gange
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Levine
authors.forename: Michael
authors.initials: M
authors.lastname: Moxley
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Xue
authors.forename: Melissa
authors.initials: M
authors.lastname: Fazzari
authors.forename: Joel M
authors.initials: JM
authors.lastname: Palefsky
authors.forename: Howard D
authors.initials: HD
authors.lastname: Strickler
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000378:metabolism / Q000821:virology; D010865:Pilot Projects; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000821:virology
chemical_list: D004279:DNA, Viral; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I