[Decreased bone mineral density in pre-menopause women with prolactinoma].
Tumoral hyperprolactinemia and consequent hypogonadism have been associated with osteoporosis. Bone mineral density (BMD) was measured by dual-energy RX absorptiometry in 24 patients with prolactinoma (15 macro and 9 micro adenomas; age range = 18 to 49 years). Student unpaired t or Mann-Whitney tests were used to compare groups, and Spearman test studied correlations. Lumbar spine (LS) was the most affected, as LS Z-score was < -2 SD in 20.83% of the patients. No difference was found in densitometric parameters for the comparison between macro and microprolactinoma, or those with normal prolactin versus hyperprolactinemia. LS BMD and LS Z-score were higher in the patients with > 8 menstrual cycles in the preceding year then in those with oligoamenorrhea (p = 0.030). The number of cycles was correlated to LS BMD (r = 0.515, p = 0.017) and body mass index to femoral neck BMD (r = 0.563, p = 0.006) and total femur BMD (r = 0.529, p = 0.011).


CONCLUSIONS
Decreased bone mineral density was detected in 20.83% of our young patients with prolactinoma. The great involvement of trabecular bone skeletal regions, such as vertebrae, suggests the participation of hypogonadism in the pathogenesis of bone disease. Irrespective of prolactin levels, return to normal menses seems the best index of good control.
Bussade
Isabela
I
Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal Rio de Janeiro, RJ. ibussade@terra.com.br
Naliato
Erika C O
EC
Mendonça
Laura Maria C
LM
Violante
Alice H D
AH
Farias
Maria Lucia F
ML
D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003720:Densitometry; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000503:physiopathology*; D008597:Menstrual Cycle; D008598:Menstruation; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000503:physiopathology*; D017697:Premenopause / Q000502:physiology*; D015175:Prolactinoma / Q000150:complications / Q000503:physiopathology*; D018709:Statistics, Nonparametric