title: Is joint hypermobility important in prepubertal children?
abstract: The purpose of this study was to investigate serum prolidase activity and its relationship with collagen metabolism and joint hypermobility, and to determine the prevalence and characteristics of joint hypermobility in prepubertal children. Serum prolidase activity was measured spectrophotometrically. Joint hypermobility was defined using Beighton criteria. The children underwent complete history and physical examination. Serum levels of prolidase were lower in the hypermobile group compared with controls and no statistical difference (1,598.61 +/- 54.99, 1,741.89 +/- 57.54; P > 0.05). However, there was significant negative correlation between prolidase level and Beighton score (r = -0.295, P = 0.002). The prevalence of hypermobility was distributed as follows: >or=4, 39.3%; >or=5, 22.7%; >or=6, 13.3%. There was correlation between joint hypermobility and pes planus (P = 0.006), arthralgia (P = 0.042), and musculoskeletal disorders in mother and/or father (P < 0.001). The decrease in prolidase activity may be related with collagen metabolism in joint hypermobility Therefore, joint hypermobility appeared to warrant further investigation due to concomitant signs and symptoms.
authors.affiliation: Department of Physical Medicine and Rehabilitation, School of Medicine, Harran University, PK:89, Sanliurfa, Merkez, Turkey. pyazgan@harran.edu.tr
authors.forename: Pelin
authors.initials: P
authors.lastname: Yazgan
authors.forename: Iclal
authors.initials: I
authors.lastname: Geyikli
authors.forename: Dost
authors.initials: D
authors.lastname: Zeyrek
authors.forename: Lutfu
authors.initials: L
authors.lastname: Baktiroglu
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kurcer
mesh_terms: D018771:Arthralgia; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000378:metabolism; D003430:Cross-Sectional Studies; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D005413:Flatfoot; D006801:Humans; D007593:Joint Instability / Q000201:enzymology*; D008297:Male; D010290:Parents; D016059:Range of Motion, Articular
chemical_list: D003094:Collagen; D004150:Dipeptidases; C022449:proline dipeptidase