Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study.
We compared immunohistochemical expression of hepatocyte growth factor (HGF), c-met, alpha-inhibin, estrogen receptor (ER), and progesterone receptor (PR) in 10 pancreatic mucinous cystic neoplasms (PMCNs), 8 hepatobiliary cystadenomas (HBCs), and 6 simple liver cysts (SLCs).All HBCs and PMCNs were in women (mean ages, 45.7 and 54.9 years, respectively; P > .05). All HBCs had abundant stroma; PMCN stromal density was more variable (score, 3.0 vs 1.8; P < .05). Stroma in HBCs had greater ER and PR staining (both P < .05) and more consistent, focal, strong reactivity for alpha-inhibin than PMCNs (P < .05). SLCs were found in men and women, lacked ovarian-type stroma, and were negative for ER, PR, and alpha-inhibin. HGF expression was not significantly different in the epithelium of HBCs, PMCNs, and SLCs; c-met expression in the epithelium of HBCs and PMCNs was significantly stronger than in SLCs (P < .05). Differences in stromal density and ER, PR, and alpha-inhibin immunoreactivity in HBCs and PMCNs suggest that different hormonal environments in the liver and pancreas contribute to stromal variation. Up-regulation of c-met in HBCs and PMCNs suggests c-met activation in the pathogenesis of pancreaticobiliary cystic neoplasms.
Lam
Maggie M
MM
Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA.
Swanson
Paul E
PE
Upton
Melissa P
MP
Yeh
Matthew M
MM
D000328:Adult; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology*; D003537:Cystadenoma / Q000378:metabolism* / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D003560:Cysts / Q000378:metabolism / Q000473:pathology; D005260:Female; D017228:Hepatocyte Growth Factor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010053:Ovary / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D017154:Stromal Cells / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C094377:inhibin-alpha subunit; D007265:Inhibins; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met