[Current aspects of research on adrenergic receptor].
Adrenergic receptor is one of the superfamilies of G-protein-coupled receptor. Its members are homologous in structure and diverse in function and are among the most pursued targets for drug development. Molecular pharmacological studies have established classification, structure, and function of adrenergic receptors approximately 100 years after Dr Langley had first referred to the philosophical concept of receptive substance. Molecular technology can identify mediating receptor subtype for each function. In this review, I focus on the current and evolving understanding of adrenergic receptor, especially relevant to the clinical settings such as heart failure and inverse agonism, and research topics such as desensitization and polymorphism, for all anesthesiologists.
Mizobe
Toshiki
T
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto.
D000818:Animals; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D051379:Mice; D011110:Polymorphism, Genetic; D011941:Receptors, Adrenergic / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D011941:Receptors, Adrenergic; C496567:GRK2 protein, human; D054769:G-Protein-Coupled Receptor Kinase 2