Navigating through models of chemotaxis.
Chemotaxis in eukaryotic cells involves the coordination of several related but separable processes: motility, polarization, and gradient sensing. Mathematical models that have been proposed to explain chemotaxis typically focus on only one of these processes. We summarize the strengths and weaknesses of the models and point out the need for an integrated model.
Iglesias
Pablo A
PA
Department of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. pi@jhu.edu
Devreotes
Peter N
PN
D000818:Animals; D016764:Cell Polarity; D002633:Chemotaxis; D008954:Models, Biological