Successful resolution of cardiac mycetomas by combined liposomal Amphotericin B with Fluconazole treatment in premature neonates.
This manuscript reports on two very low birth weight premature infants with respiratory distress, receiving parenteral nutrition and broad-spectrum antibiotics for about 3 weeks, who developed Candida albicans sepsis associated with fungal mycoses and endocarditis, despite treatment with Amphotericin B and Caspofungin. On days 40 and 47, respectively, antifungal therapy was modified to liposomal Amphotericin B combined with Fluconazole 6 mg/kg/day for 4 weeks, resulting in complete resolution of the mycetomas. Our observations suggest that the combination of liposomal Amphotericin B with Fluconazole is able to result in complete resolution of cardiac mycetomas in preterm infants.
Karatza
Ageliki A
AA
Department of Paediatrics, Neonatal Intensive Care Unit, General University Hospital of Patras, 26504, Rio, Patras, Greece.
Dimitriou
Gabriel
G
Marangos
Markos
M
Christofidou
Myrto
M
Pavlou
Vassiliki
V
Giannakopoulos
Ioannis
I
Darzentas
Antonios
A
Mantagos
Stefanos P
SP
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy*; D004338:Drug Combinations; D004696:Endocarditis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008081:Liposomes; D008297:Male; D008271:Mycetoma / Q000150:complications* / Q000188:drug therapy*
D000935:Antifungal Agents; D004338:Drug Combinations; D008081:Liposomes; D000666:Amphotericin B; D015725:Fluconazole