title: Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients.
abstract: BACKGROUND
  Chronic graft-versus-host disease (cGVHD) is a common but serious complication of allogeneic haematopoietic stem cell transplantation (HSCT). Oral involvement of cGVHD occurs in 80 to 100% of patients suffering from cGVHD and may be the early manifestation of this complication.
  
  
  OBJECTIVE
  To study whether the histological changes of oral cGVHD are detectable in apparently normal oral mucosa of HSCT patients without clinical manifestations of the disease.
  
  
  METHODS
  This study enrolled 13 adult patients who underwent allogeneic HSCT for haematological malignancies. The presence of lichenoid, atrophic or erythematous changes of the oral mucosa detected on oral examination approximately 100 days after the HSCT was regarded as positive for cGVHD. An incisional biopsy of the oral mucosa was taken from patients with and without oral cGVHD and the specimens were examined by a pathologist who was unaware of the clinical state of the sampled mucosa.
  
  
  RESULTS
  Biopsies were taken from four patients with clinical manifestations of oral cGVHD and from nine patients with apparently normal oral mucosa. Histological cGVHD changes were detected in each of the four patients (100%) with clinical manifestations of oral cGVHD and in six of the nine patients (66.6%) with apparently healthy mucosa.
  
  
  CONCLUSIONS
  Although the histological changes in the oral mucosa without corresponding clinical alterations that were detected in this study are insufficient for a definite diagnosis of oral cGVHD, it appears important to investigate the amount of histological change in predicting clinical onset. A longer follow-up period in patients showing histological changes with no clinical manifestations may elucidate whether these changes are predictive of clinically evident lesions in the mouth or other sites.
authors.affiliation: Unit of Oral Pathology and Medicine, School of Dentistry, University of Milan, Via Beldiletto 1, 20142 Milan, Italy. federica.demarosi@unimi.it
authors.forename: F
authors.initials: F
authors.lastname: Demarosi
authors.forename: G
authors.initials: G
authors.lastname: Lodi
authors.forename: A
authors.initials: A
authors.lastname: Carrassi
authors.forename: L
authors.initials: L
authors.lastname: Moneghini
authors.forename: B
authors.initials: B
authors.lastname: Sarina
authors.forename: A
authors.initials: A
authors.lastname: Sardella
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000473:pathology*; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D014184:Transplantation, Homologous