title: Successful treatment of a morbidly obese and growth-retarded adolescent with Williams-Beuren Syndrome by combining the medication of growth hormone and sibutramine.
abstract: A 16-year-old male adolescent diagnosed to have the Williams-Beuren syndrome was referred to our obesity outpatient clinic, due to his morbid obesity (body mass index 39.2 kilograms per square metre) and gluttony. After several unsuccessful dietary treatments, we started therapy with sibutramine. As growth hormone (GH) deficiency was diagnosed by an additional GH-stimulation test, we commenced with a GH-treatment. This well-tolerated combination therapy led to a remarkable weight loss of 10 kg and a growth-rate acceleration of 3.7 cm/year. Nine months after stopping the treatment with sibutramine, a partial weight gain was noticed. This case report justifies further research work on a combination therapy with sibutramine and GH for similar cases.
authors.affiliation: Department of Internal Medicine, State Hospital Muerzzuschlag, Grazerstrasse 63-65, 8680 Muerzzuschlag, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Bahadori
authors.forename: E
authors.initials: E
authors.lastname: Uitz
authors.forename: K
authors.initials: K
authors.lastname: Tonninger-Bahadori
authors.forename: M H
authors.initials: MH
authors.lastname: Moghadasian
mesh_terms: D000293:Adolescent; D001067:Appetite Depressants / Q000008:administration & dosage*; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D003503:Cyclobutanes / Q000008:administration & dosage*; D019382:Human Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000188:drug therapy*; D015430:Weight Gain; D015431:Weight Loss; D018980:Williams Syndrome / Q000150:complications*
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D019382:Human Growth Hormone; C058254:sibutramine