title: Evaluation of the interaction between sodium hypochlorite and chlorhexidine gluconate and its effect on root dentin.
abstract: The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) forms a precipitate. The aim of this study was to evaluate the effect of irrigating root canals with a combination of NaOCl and CHX on root dentin and dentinal tubules by using the environmental scanning electron microscope (ESEM) and a computer program (Photoshop CS2). Forty-four extracted single-rooted human teeth were instrumented and irrigated with both NaOCl and CHX to produce a precipitate. Root canal surfaces were analyzed with the ESEM. The amount of remaining debris and number of patent tubules were determined. There were no significant differences in remaining debris between the negative control group and the experimental groups. There were significantly fewer patent tubules in the experimental groups when compared with the negative control group. The NaOCl/CHX precipitate tends to occlude the dentinal tubules. Until this precipitate is studied further, caution should be exercised when irrigating with NaOCl and CHX.
authors.affiliation: Department of Endodontology, Oregon Health & Science University, Portland, Oregon 97239, USA.
authors.forename: Tung B
authors.initials: TB
authors.lastname: Bui
authors.forename: J Craig
authors.initials: JC
authors.lastname: Baumgartner
authors.forename: John C
authors.initials: JC
authors.lastname: Mitchell
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D011232:Chemical Precipitation; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003786:Dental Pulp Cavity / Q000187:drug effects* / Q000648:ultrastructure; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D004347:Drug Interactions; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012388:Root Canal Irrigants / Q000494:pharmacology*; D018915:Root Canal Preparation / Q000379:methods; D016369:Smear Layer; D012973:Sodium Hypochlorite / Q000494:pharmacology*
chemical_list: D000891:Anti-Infective Agents, Local; D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002710:Chlorhexidine