title: Effectiveness of cryotherapy treatment for cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To assess the effectiveness of cryotherapy treatment delivered by general practitioners in primary care settings, as part of a screen-and-treat approach for cervical cancer prevention.
  
  
  METHODS
  Women aged between 25 and 49 years residing in San Martin, Peru, who were positive on visual inspection screening were treated, if eligible, with cryotherapy following biopsy. At 12 months post cryotherapy treatment the participants were evaluated for treatment effectiveness and examined by visual inspection and Papanicolaou test and, if positive, referred to a gynecologist for colposcopy and biopsy.
  
  
  RESULTS
  Cryotherapy treatment was performed for 1398 women; of these, 531 (38%) had a histology result of cervical intraepithelial neoplasia (CIN). Cryotherapy effectively cured CIN in 418 (88%) women, including 49 (70%) women with a baseline diagnosis of CIN 3.
  
  
  CONCLUSIONS
  Cryotherapy is an effective treatment for cervical precancerous lesions; it can easily be administered by general practitioners in primary care settings following visual inspection screening.
authors.affiliation: Unit of Non-Communicable Diseases, Pan American Health Organization, Washington, DC, USA. lucianis@paho.org
authors.forename: Silvana
authors.initials: S
authors.lastname: Luciani
authors.forename: Miguel
authors.initials: M
authors.lastname: Gonzales
authors.forename: Sergio
authors.initials: S
authors.lastname: Munoz
authors.forename: Jose
authors.initials: J
authors.lastname: Jeronimo
authors.forename: Sylvia
authors.initials: S
authors.lastname: Robles
mesh_terms: D000328:Adult; D017679:Cryotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D010568:Peru; D011320:Primary Health Care; D011446:Prospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000628:therapy*