title: Utility of sonographically guided biopsy in metabolically suspected recurrent lymphoma.
abstract: OBJECTIVE
  The purpose of this study was to determine the diagnostic accuracy of sonographically guided biopsy of [(18)F]fluorodeoxyglucose (FDG)-avid foci on positron emission tomography (PET)/computed tomography (CT) in patients with lymphoma.
  
  
  METHODS
  We retrospectively reviewed the medical records of 56 patients with lymphoma (25 male and 31 female; mean age, 48.5 years; range, 22-80 years) who underwent sonographically guided biopsy of hypermetabolic FDG-avid foci precisely localized by PET/CT. Biopsies were performed up to 3 months after PET/CT. The accuracy of core biopsy was calculated and compared with clinical follow-up and histopathologic results of open biopsy.
  
  
  RESULTS
  Sixty-six sonographically guided biopsies were performed in the 56 patients. Histopathologic results were conclusive in 53 (80%) of 66. No complications occurred during or after the procedure. The overall sensitivity, specificity, positive predictive value, and accuracy for diagnosis of lymphoma were 100%, 95%, 97%, and 98%, respectively.
  
  
  CONCLUSIONS
  Sonographically guided biopsy is a safe and effective means for investigating metabolically active lesions on FDG-PET/CT in patients with known lymphoma.
authors.affiliation: Department of Medical Imaging, Rambam Medical Center, Haifa, Israel. m_soudack@rambam.health.gov.il
authors.forename: Michalle
authors.initials: M
authors.lastname: Soudack
authors.forename: Rachel Bar
authors.initials: RB
authors.lastname: Shalom
authors.forename: Ora
authors.initials: O
authors.lastname: Israel
authors.forename: Yehudith
authors.initials: Y
authors.lastname: Ben-Arie
authors.forename: Zofia
authors.initials: Z
authors.lastname: Levy
authors.forename: Diana
authors.initials: D
authors.lastname: Gaitini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18