[Optimization of hepatosplanchnic oxygenation in septic shock].
Microcirculatory dysfunction, reduced oxygen supply and thus impaired hepatosplanchnic organ function, play a pivotal role in the clinical manifestation of sepsis and septic shock. Early correction of the perfusion mismatch is essential to maintain end-organ and gut mu-cosa barrier function and thus to prevent bacterial translocation, bacteraemia and possible multiple organ failure. This review will outline the clinical tightrope-walk optimizing hepa-tosplanchnic oxygen supply while maintaining adequate end-organ perfusion pressure and highlight the diagnostic challenges and limitations faced in clinical practice.
Beck
Christopher
C
Klinik für Anästhesiologie des Universitätsklinikums Düsseldorf. christopher.beck@med.uni-duesseldorf.de
Pannen
Benedikt H J
BH
Picker
Olaf
O
D001424:Bacterial Infections / Q000503:physiopathology / Q000628:therapy*; D005858:Germany; D006801:Humans; D008102:Liver Circulation; D009102:Multiple Organ Failure / Q000517:prevention & control; D010100:Oxygen / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011785:Quality Assurance, Health Care / Q000379:methods*; D012772:Shock, Septic / Q000503:physiopathology / Q000628:therapy*; D013152:Splanchnic Circulation; D014657:Vasculitis / Q000503:physiopathology / Q000628:therapy*
D010100:Oxygen