HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives.
The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak IA stationary phase.
Biava
Mariangela
M
Università La Sapienza, Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, 00185 Rome, Italy.
Cirilli
Roberto
R
Fares
Vincenzo
V
Ferretti
Rosella
R
Gallinella
Bruno
B
La Torre
Francesco
F
Poce
Giovanna
G
Porretta
Giulio Cesare
GC
Supino
Sibilla
S
Villani
Claudio
C
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles