[The prognostic value of positive peritoneal lavage cytology and the prevention of peritoneal dissemination after colorectal surgery].
Peritoneal washing cytology during surgery was done in 745 patients with colorectal cancer. The positive washing cytology rate was 49/745 (6.6%). The peritoneal recurrence rates were 12/22 (54.5%) and 8/682 (1.3%) among patients with positive and negative peritoneal washing, respectively (p < 0.0001). The 5-year survival rate is 89.4% of the patients with positive cytology and 38.2% with negative cytology. The patients with positive cytology have a significantly lower survival rate than the negative one (p < 0.0001). Eleven patients of the positive cytology received intraperitoneal administration of MMC. Peritoneal dissemination occurred in 3/11 (27.3%) of the MMC treated group and 9/11 (81.8%) in the untreated group (p = 0.030). Our results indicated that intraperitoneal administration of MMC was an effective method of preventing peritoneal dissemination after resection of colorectal cancer.
Tanida
Tsukasa
T
Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease.
Noura
Shingo
S
Ohue
Masayuki
M
Seki
Yousuke
Y
Gotoh
Kunihito
K
Motoori
Masaaki
M
Kishi
Kentarou
K
Takachi
Kou
K
Yamada
Terumasa
T
Miyashiro
Isao
I
Ohigashi
Hiroaki
H
Yano
Masahiko
M
Ishikawa
Osamu
O
Imaoka
Shingi
S
Murata
Kohei
K
Kameyama
Masao
M
D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D003107:Colorectal Surgery; D006801:Humans; D009367:Neoplasm Staging; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary*; D011379:Prognosis; D015996:Survival Rate