title: Vascular versus myocardial dysfunction in acute coronary syndrome: are the adhesion molecules as powerful as NT-proBNP for long-term risk stratification?
abstract: OBJECTIVE
  To determine if elevations of adhesion molecules in acute coronary syndrome (ACS) are useful for risk stratification.
  
  
  METHODS
  A cell adhesion array (Randox Ltd.) and NT-proBNP were measured in 216 ACS patients.
  
  
  RESULTS
  Kaplan-Meier and Cox models indicate early elevations of NT-proBNP but not the adhesion molecules are predictive of future death/myocardial infarction.
  
  
  CONCLUSIONS
  Elevations of adhesion molecules early after pain onset in ACS are not useful for long-term risk stratification.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. kavsakp@mcmaster.ca
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kavsak
authors.forename: Dennis T
authors.initials: DT
authors.lastname: Ko
authors.forename: Alice M
authors.initials: AM
authors.lastname: Newman
authors.forename: Viliam
authors.initials: V
authors.lastname: Lustig
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Palomaki
authors.forename: Andrew R
authors.initials: AR
authors.lastname: MacRae
authors.forename: Allan S
authors.initials: AS
authors.lastname: Jaffe
mesh_terms: D054058:Acute Coronary Syndrome / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D046228:Microarray Analysis / Q000379:methods; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011498:Protein Precursors / Q000378:metabolism*; D012307:Risk Factors; D020107:Troponin T / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D010446:Peptide Fragments; D011498:Protein Precursors; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain