title: Determination of the dietary absorption efficiency of hexachlorobenzene with the channel catfish (Ictalurus punctatus).
abstract: This study was designed to experimentally measure the assimilation efficiency of hexachlorobenzene (HCB) in a warm-water, benthic-feeding fish species, the channel catfish (Ictalurus punctatus). Catfish were exposed to (14)C-radiolabeled HCB in catfish food over a 28-day exposure period, followed by a 14-day clearance period. Over the experimental period, the total (14)C residues were measured in fish tissue and a simple two-box kinetic model was applied to the data to simulate uptake and clearance dynamics. No detectable metabolism of HCB by catfish was found. A two-box kinetic model effectively modeled the uptake and clearance of (14)C-HCB in catfish, with a calculated assimilation efficiency of the chemical into the whole catfish of 67% (growth corrected). The growth-corrected pseudo first-order elimination half-life of (14)C-HCB from whole catfish was determined to be 29 days (k(2)=0.024 day(-1)).
authors.affiliation: The Dow Chemical Company, Toxicology, Environmental Research and Consulting Laboratory, 1803 Building, Midland, MI 48674, USA. kent.woodburn@dowcorning.com
authors.forename: Kent B
authors.initials: KB
authors.lastname: Woodburn
authors.forename: Troy A
authors.initials: TA
authors.lastname: Marino
authors.forename: E Lynn
authors.initials: EL
authors.lastname: McClymont
authors.forename: David L
authors.initials: DL
authors.lastname: Rick
mesh_terms: D000042:Absorption / Q000502:physiology*; D000821:Animal Feed; D000818:Animals; D002250:Carbon Radioisotopes; D004032:Diet; D005506:Food Contamination; D005659:Fungicides, Industrial / Q000737:chemistry / Q000493:pharmacokinetics*; D006581:Hexachlorobenzene / Q000737:chemistry / Q000493:pharmacokinetics*; D007059:Ictaluridae / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D002250:Carbon Radioisotopes; D005659:Fungicides, Industrial; D014874:Water Pollutants, Chemical; D006581:Hexachlorobenzene