title: Oncologic outcomes of laparoscopic surgery for rectal cancer: a systematic review and meta-analysis of the literature.
abstract: OBJECTIVE
  To review and compare the oncologic outcomes in patients with rectal cancer undergoing laparoscopic vs. open rectal surgery.
  
  
  METHODS
  An electronic literature search was performed for trials reporting oncologic outcomes for laparoscopic rectal resections. Variables of interest were survival, recurrence rates, margin status and nodal retrieval. Trials were excluded if variables were not specifically analysed for rectal resections. A meta-analysis was performed to assess the difference in oncologic outcomes between the two treatment approaches.
  
  
  RESULTS
  Data on a total of 1403 laparoscopic (LG) and 1755 open (OG) rectal resections were gathered from 24 publications. Overall survival at 3 years (LG=76%, OG=69%) was not statistically different between the two treatment groups. The mean local recurrence rates were 7% for laparoscopic and 8% for open procedures (NS). There was no difference in radial margin positivity, 5% of patients undergoing laparoscopic surgery compared to 8% for open surgery. Laparoscopic procedures harvested a mean of 10 nodes as compared to 12 for open procedures, p=0.001.
  
  
  CONCLUSIONS
  Data gathered in this meta-analysis indicate that there are no oncologic differences between laparoscopic and open resections for treatment of primary rectal cancer.
authors.affiliation: Department of General Oncologic Surgery, City of Hope Medical Center, 1500 Duarte Road, Duarte, CA 91010, USA.
authors.forename: C
authors.initials: C
authors.lastname: Anderson
authors.forename: G
authors.initials: G
authors.lastname: Uman
authors.forename: A
authors.initials: A
authors.lastname: Pigazzi
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D010535:Laparoscopy; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery*