title: Early validation study of 64-slice multidetector computed tomography for the assessment of myocardial viability and the prediction of left ventricular remodelling after acute myocardial infarction.
abstract: OBJECTIVE
  We aim to validate the ability of multidetector computed tomography (MDCT) for assessing myocardial viability and predicting left ventricular (LV) remodelling after acute myocardial infarction (AMI).
  
  
  RESULTS
  In 52 consecutive patients with first AMI, 64-slice MDCT without iodine re-injection was performed immediately following coronary stenting. Electrocardiogram-gated thallium-201 single-photon emission tomography was performed using QGS programs within 5 days and 6 months after onset. Among the 52 patients, 18 patients (Group A) showed transmural contrast-delayed enhancement on MDCT images, 20 patients (Group B) showed subendocardial contrast-delayed enhancement, and 14 patients (Group C) had no contrast-delayed enhancement. In the acute phase, peak creatine kinase-MB [497 (189-744), 182 (90-358), 85 (40-204) IU/mL, respectively, P = 0.0004] was significantly higher in Group A, while the incidence of myocardial blush grade 3 (22, 67, 75%, respectively, P = 0.001) and LV ejection fraction (41 +/- 7, 53 +/- 12, 62 +/- 11%, respectively, P < 0.0001) were significantly lower in Group A. During the 6-month period, LV remodelling (P = 0.001) and the number of rehospitalization for heart failure (P = 0.0017) were more significantly observed in Group A.
  
  
  CONCLUSIONS
  Myocardial contrast-delayed enhancement patterns provide promising information regarding myocardial viability, LV remodelling, and prognosis in AMI.
authors.affiliation: Department of Cardiology, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka, Japan. asato@yf6.so-net.ne.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.forename: Michiaki
authors.initials: M
authors.lastname: Hiroe
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nozato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hikita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ito
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohigashi
authors.forename: Mieko
authors.initials: M
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D015607:Stents; D013318:Stroke Volume / Q000502:physiology; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D003287:Contrast Media; D013794:Thallium Radioisotopes