title: Relationship between serum cholinesterase level and urinary bladder activity in patients with or without overactive bladder and/or neurogenic bladder.
abstract: We compared the serum cholinesterase (ChE) level and various parameters between patients with or without overactive bladder (OAB) and/or neurogenic bladder (NB). A total of 258 patients who met the following criteria were enrolled: the presence/absence of OAB and/or NB was documented, laboratory data were available, and liver and renal functions were normal. Patients were divided into the 3 groups: 1) a NB+/OAB+ group who had both NB and OAB, 2) a NB-/OAB+ group who had OAB alone, and 3) an OAB- group who did not have OAB. The relationship between the presence of OAB and various biochemical parameters were examined, as well as the therapeutic outcome in relation to the same biochemical parameters. Forty-three patients had both NB and OAB (NB+/OAB+), 66 patients had OAB without NB (NB-/OAB+), and 149 patients had no OAB (OAB-). Serum ChE, total protein, and albumin levels were lower in the NB-/OAB+ group than the NB+/OAB+ group or the OAB- group. In the NB-/OAB+ group, a higher serum albumin or ChE level was associated with a better therapeutic outcome. These results suggest that a decrease of serum ChE level is related to the occurrence of OAB and the poor response to treatment in OAB patients without NB.
authors.affiliation: Division of Urology, Department of Organ-oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan. sugaya@med.u-ryukyu.ac.jp
authors.forename: Kimio
authors.initials: K
authors.lastname: Sugaya
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Onaga
authors.forename: Saori
authors.initials: S
authors.lastname: Nishijima
authors.forename: Minoru
authors.initials: M
authors.lastname: Miyazato
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Oshiro
authors.forename: Sanehiro
authors.initials: S
authors.lastname: Hokama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Uchida
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D012709:Serum Albumin / Q000378:metabolism; D001743:Urinary Bladder / Q000503:physiopathology*; D001750:Urinary Bladder, Neurogenic / Q000378:metabolism* / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D012709:Serum Albumin; D002802:Cholinesterases