title: Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.
abstract: The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477, USA.
authors.forename: Carl R
authors.initials: CR
authors.lastname: Illig
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Chen
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Wall
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Wilson
authors.forename: Shelley K
authors.initials: SK
authors.lastname: Ballentine
authors.forename: M Jonathan
authors.initials: MJ
authors.lastname: Rudolph
authors.forename: Renee L
authors.initials: RL
authors.lastname: DesJarlais
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Chen
authors.forename: Carsten
authors.initials: C
authors.lastname: Schubert
authors.forename: Ioanna
authors.initials: I
authors.lastname: Petrounia
authors.forename: Carl S
authors.initials: CS
authors.lastname: Crysler
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Molloy
authors.forename: Margery A
authors.initials: MA
authors.lastname: Chaikin
authors.forename: Carl L
authors.initials: CL
authors.lastname: Manthey
authors.forename: Mark R
authors.initials: MR
authors.lastname: Player
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Tomczuk
authors.forename: Sanath K
authors.initials: SK
authors.lastname: Meegalla
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy; D003094:Collagen; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D003094:Collagen; D016186:Receptor, Macrophage Colony-Stimulating Factor