title: Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes.
abstract: To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.
authors.affiliation: Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, and BK21 CLS, Seoul National University School of Dentistry, 28 Yeonkun-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea.
authors.forename: Choung Ryong
authors.initials: CR
authors.lastname: Yoo
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Yeo
authors.forename: Ko Eun
authors.initials: KE
authors.lastname: Park
authors.forename: Ji Hun
authors.initials: JH
authors.lastname: Park
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Park
authors.forename: Byung-Moo
authors.initials: BM
authors.lastname: Min
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D002686:Chitin / Q000737:chemistry*; D004563:Electrochemistry; D004817:Epidermis / Q000378:metabolism; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D047011:Silk / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D047011:Silk; D014867:Water; D002686:Chitin; D005349:Fibroins