title: Global left-ventricular function by tissue Doppler imaging in pediatric dialysis patients.
abstract: Cardiovascular abnormalities are observed in most children with end-stage renal disease (ESRD). The aim of this study was evaluation of left-ventricular (LV) myocardial performance using tissue-Doppler imaging (TDI) in patients with ESRD. Twenty-five patients with ESRD and 25 healthy gender- and age-matched control subjects were assessed with conventional M-mode echocardiography, pulsed-wave Doppler (PWD), and TDI. Myocardial Performance Index (MPI) and LV mass index (LVMI) were calculated. MPI and conventional echo-Doppler indices were compared in the ESRD and control groups. Significant differences were present in the mean systolic and diastolic blood pressure (BP) between children with ESRD and healthy children (p = 0.007 and p < 0.001, respectively). The mean LVMI was significantly greater in the patient group (p < 0.001). The tissue-Doppler MPI of patients was significantly higher than that in healthy children (p < 0.001). LVMI was significantly correlated with systolic and diastolic BP. MPI obtained by TDI was significantly correlated with LVMI. Our study confirms that LV dysfunction is present in patients with ESRD and hypertension is an important risk factor.
authors.affiliation: Department of Pediatric Cardiology, Ankara University School of Medicine, Huzur Mah. 25 Sokak, No: 6, 11 Oveçler, Ankara, Turkey, tayfunucar@yahoo.com
authors.forename: Tayfun
authors.initials: T
authors.lastname: Uçar
authors.forename: Ercan
authors.initials: E
authors.lastname: Tutar
authors.forename: Fatoş
authors.initials: F
authors.lastname: Yalçinkaya
authors.forename: Nilgün
authors.initials: N
authors.lastname: Cakar
authors.forename: Z Birsin
authors.initials: ZB
authors.lastname: Ozçakar
authors.forename: Semra
authors.initials: S
authors.lastname: Atalay
authors.forename: Nermin
authors.initials: N
authors.lastname: Uncu
authors.forename: Nazli
authors.initials: N
authors.lastname: Kara
authors.forename: Mesiha
authors.initials: M
authors.lastname: Ekim
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D002648:Child; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D011379:Prognosis; D006435:Renal Dialysis / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*