Catalytic inactivation of human carbonic anhydrase I by a metallopeptide-sulfonamide conjugate is mediated by oxidation of active site residues.
Gokhale
Nikhil H
NH
Evans Laboratory of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Bradford
Seth
S
Cowan
J A
JA
D001665:Binding Sites / Q000187:drug effects; D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D015032:Zinc / Q000737:chemistry
D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D010455:Peptides; D013449:Sulfonamides; D003300:Copper; D024401:Carbonic Anhydrase I; D015032:Zinc