title: [Oxidative biology and clinical implications of peroxynitrite].
abstract: Peroxynitrite is a strong biological oxidant formed from the reaction between two free radicals, superoxide and nitric oxide. It inflicts serious damages to most biomolecules, including proteins, lipids and nucleic acids, either through direct oxidation or through the secondary generation of highly reactive free radicals. When such damage reaches a critical threshold, cells eventually die by necrosis or apoptosis. An excessive production of peroxynitrite is instrumental in the development of organ damage and dysfunction in conditions such as circulatory shock and ischemia-reperfusion. In such circumstances, various synthetic metalloporphyrins, able to degrade peroxynitrite, disclose important beneficial effects in animal models, and might therefore represent novel pharmacological agents in the future.
authors.affiliation: Service de médecine intensive adulte, CHUV-BH. lucas.liaudet@chuv.ch
authors.forename: Lucas
authors.initials: L
authors.lastname: Liaudet
mesh_terms: D017209:Apoptosis; D006801:Humans; D009102:Multiple Organ Failure / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism; D012769:Shock / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid