title: HIVcleave: a web-server for predicting human immunodeficiency virus protease cleavage sites in proteins.
abstract: According to the ''distorted key theory'' [K.C. Chou, Analytical Biochemistry, 233 (1996) 1-14], the information of cleavage sites of proteins by HIV (human immunodeficiency virus) protease is very useful for finding effective inhibitors against HIV, the culprit of AIDS (acquired immunodeficiency syndrome). To meet the increasing need in this regard, a web-server called HIVcleave was established at http://chou.med.harvard.edu/bioinf/HIV/. In this note we provide a step-to-step guide for how to use HIVcleave to identify the cleavage sites of a query protein sequence by HIV-1 and HIV-2 proteases, respectively.
authors.affiliation: Gordon Life Science Institute, San Diego, CA 92130, USA.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Shen
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Chou
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D003201:Computers; D016333:HIV Protease / Q000378:metabolism*; D006801:Humans; D020407:Internet; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D010455:Peptides; D016333:HIV Protease