title: Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions.
abstract: Post-trauma and post-partum pelvic ring instability and non-union are treated operatively with internal fixation and a biological enhancement stimulus. The application of BMP-7 in nine cases of persistent instability located at the anterior or the posterior elements of the pelvic girdle is prospectively evaluated for its safety and efficacy. Fusion was achieved in 89% of the patients. 78% of the patients reported excellent or good subjective functional results at a median follow up period of 12 months (range 12-27). The utilisation of BMP-7 was not associated with any adverse reactions or complications. Encouraging results of biological enhancement of bone healing with BMP-7 at the clinical setting of traumatic pelvic ring non-unions and postpartum instability were achieved. The implantation of BMP-7 in pelvic reconstruction procedures adds another alternative to the treatment methods of contemporary orthopaedics.
authors.affiliation: Academic Dept of Trauma & Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK. pgiannoudi@aol.com
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
authors.forename: Spyridon
authors.initials: S
authors.lastname: Psarakis
authors.forename: Nikolaos K
authors.initials: NK
authors.lastname: Kanakaris
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Pape
mesh_terms: D000328:Adult; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects; D005599:Fractures, Ununited / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000293:injuries*; D049590:Postpartum Period; D011446:Prospective Studies; D012446:Sacroiliac Joint / Q000293:injuries*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta