title: Breast carcinoma arising within fibroadenomas. Report of four observations.
abstract: BACKGROUND
  Fibroadenoma is a frequent benign breast tumor affecting young woman. The incidence of a carcinoma within adenofibromas is estimated at 0.1 to 0.3%.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the outcome of patients with breast carcinoma arising within adenofibroma and to determine the clinical characteristics and the prognosis of this rare entity.
  
  
  METHODS
  We retrospectively report on four cases of carcinomas arising in mammary fibroadenomas. The mean age was 41 years (26-53). In two cases, fibroadenomas was complex, containing cysts, adenosis and apocrine metaplasia. The adjacent parenchyma contained fibrocystic dystrophy lesions associated in one case to intralobular neoplasia lesions. The treatment consisted of a conservative treatment in two cases and a mastectomy plus axillary node dissection in the two others. Radiotherapy was indicated in all cases and chemotherapy done in three cases. All patients are alive with a mean follow up of 4.25 years (3-7) without any sign of recurrence.
  
  
  CONCLUSIONS
  Every benign mammary nodule must necessarily be verified surgically to avoid misdiagnosing any carcinomatous area because at this stage its prognosis is better.
authors.affiliation: Department of surgical oncology, Salah Azaiz Institute of Tunis.
authors.forename: Jamel
authors.initials: J
authors.lastname: Ben Hassouna
authors.forename: Tarak
authors.initials: T
authors.lastname: Damak
authors.forename: Afef
authors.initials: A
authors.lastname: Ben Slama
authors.forename: Riadh
authors.initials: R
authors.lastname: Chargui
authors.forename: Tarak
authors.initials: T
authors.lastname: Ben Dhiab
authors.forename: Fethi
authors.initials: F
authors.lastname: Khomsi
authors.forename: Amor
authors.initials: A
authors.lastname: Gamoud
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Khaled
authors.initials: K
authors.lastname: Rahal
mesh_terms: D000232:Adenofibroma / Q000473:pathology*; D000328:Adult; D047688:Breast Cyst / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008408:Mastectomy; D008679:Metaplasia; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies