title: Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
abstract: The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.
authors.affiliation: Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com
authors.forename: A Chris
authors.initials: AC
authors.lastname: Krueger
authors.forename: Yibo
authors.initials: Y
authors.lastname: Xu
authors.forename: Warren M
authors.initials: WM
authors.lastname: Kati
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Kempf
authors.forename: Clarence J
authors.initials: CJ
authors.lastname: Maring
authors.forename: Keith F
authors.initials: KF
authors.lastname: McDaniel
authors.forename: Akhteruzzaman
authors.initials: A
authors.lastname: Molla
authors.forename: Debra
authors.initials: D
authors.lastname: Montgomery
authors.forename: William E
authors.initials: WE
authors.lastname: Kohlbrenner
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D011759:Pyrrolidines; D009439:Neuraminidase