Phosphatases at the heart of FoxO metabolic control.
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.
Tremblay
Michel L
ML
McGill Cancer Centre, McGill University, Montréal, PQ, H3G 1Y6, Canada. michel.tremblay@mcgill.ca <michel.tremblay@mcgill.ca>
Giguère
Vincent
V
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology*; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D008660:Metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction
D051858:Forkhead Transcription Factors; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases