Skin invasion and prognosis in node negative breast cancer: a retrospective study.
BACKGROUND
The impact of skin invasion in node negative breast cancer is uncertain.


METHODS
We determined the prognosis in 97 node negative breast cancer patients (case group) who had tumors with skin invasion. Then we compared these patients with 4500 node negative invasive breast cancer patients treated surgically in the same period.


RESULTS
Patients with skin invasion tended to be older, had more invasive lobular carcinoma and larger tumor size, and were less likely to have breast conserving surgery than those in the control group. The 5-year disease-free survival rate in the case group was 94.0%. There was no significant difference in the 10-year disease-specific overall survival rates in terms of skin invasion in node negative patients (90.7% in the case group, 92.9% in the control group; p = 0.2032).


CONCLUSIONS
Results suggest that skin invasion has no impact on survival in node negative invasive breast cancer patients. The adjuvant regimens which the individual institute applies for node negative breast cancer should be used regardless of skin invasion.
Tada
Keiichiro
K
Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan. ktada@jfcr.or.jp
Morizono
Hidetomo
H
Iijima
Kotaro
K
Miyagi
Yumi
Y
Nishimura
Seiichiro
S
Makita
Masujiro
M
Horii
Rie
R
Akiyama
Futoshi
F
Iwase
Takuji
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000556:secondary* / Q000601:surgery; D016019:Survival Analysis