High prevalence of human T-lymphotropic virus type I carriers among patients with myelodysplastic syndrome refractory anemia with excess of blasts (RAEB), RAEB in transformation and acute promyelocytic leukemia.
We examined human T-lymphotropic virus type I (HTLV-I) infection among patients with myelodysplastic syndrome (MDS), refractory anemia with excess of blasts (RAEB)/RAEB in transformation (RAEBt) and acute myelogenous leukemia (AML). The study population consisted of 151 patients: 46 with MDS RAEB/RAEBt and 105 with AML (M1, n = 15; M2, n = 39; M3, n = 18; M4, n = 19; M5, n = 9; M6, n = 3; M7, n = 2). As a reference, we examined 92 patients with refractory anemia (RA) and 405 patients with cardiovascular diseases (CVD). Thirteen patients with RAEB/RAEBt (28.3%), 11 with AML (11.6%), 27 with RA (29.3%), and 45 with CVD (11.0%) were positive for HTLV-I. Seven AML patients with HTLV-I infection had M3 acute promyelocytic leukemia (APL). The prevalences of HTLV-I infection among patients with RAEB/RAEBt (P < 0.001), APL (P = 0.001), and RA (P < 0.001) were significantly higher than that in patients with CVD. The prevalences of HTLV-I infection were still significantly higher in patients with RAEB/RAEBt (P = 0.007), APL (P = 0.017) and RA (P < 0.001) than in those with CVD matched by sex and age. Platelet counts and survival times of RAEB/RAEBt patients with infection were significantly lower than those of patients without infection.
Inoue
Hirosaka
H
Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan.
Matsushita
Kakushi
K
Arima
Naomichi
N
Hamada
Heiichiro
H
Uozumi
Kimiharu
K
Ozaki
Atsuo
A
Akimoto
Masaki
M
Kawada
Hideaki
H
Kukita
Toshimasa
T
Yoshimitsu
Makoto
M
Matsumoto
Tadashi
T
Tei
Chuwa
C
D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000821:virology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000821:virology*; D010976:Platelet Count; D015995:Prevalence; D015996:Survival Rate