A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides.
A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the micro-opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a common A118G SNP. The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively). A dominant model analysis of the A118G SNP showed an enhanced association with suicide (P = 0.0041, Odds ratio 0.575) and this significant association was observed with a logistic regression analysis that takes sex and age factors into account (P = 0.021). Our results raise the possibility that the A118G SNP of the OPRM1 gene is associated with suicide.
Hishimoto
A
A
Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan. hishitoyo@hotmail.com
Cui
H
H
Mouri
K
K
Nushida
H
H
Ueno
Y
Y
Maeda
K
K
Shirakawa
O
O
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D016728:Self-Injurious Behavior / Q000235:genetics*; D013405:Suicide
C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu