title: [Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury in rats].
abstract: OBJECTIVE
  To investigate the protective effect of Total Flavonoid of Herba Pyrolae(TFHP) on acute myocardial ischemic injury in rats.
  
  
  METHODS
  Acute myocardial ischemic models were established by i. v. injection of pituitrin and the ligation of left descending coronary artery in rats. ECG of the rat was recorded, myocardial ischemic size was evaluated, and activites of creatine phosphokinase( CK), lactate dehydrogenase (LDH) and superoxide dismutase (SOD), level of malondialdehyde (MDA) in the rat serum were determined.
  
  
  RESULTS
  In comparison with the model control, TFHP significantly reduced the incidence of ischemic arrhythmia induced by pituitrin, size of myocardial infarction, release of myocardial CK and LDH caused by the ligation of left descending coronary artery in rats. The primary study of action mechanism showed that TFHP decreased MDA level and increased SOD activity in the rat serum.
  
  
  CONCLUSIONS
  TFHP provide a protective effect on acute myocardial ischemic injury via antioxidation.
authors.affiliation: Department of Pharmacology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Cun-Jing
authors.initials: CJ
authors.lastname: Ding
authors.forename: Jun-tian
authors.initials: JT
authors.lastname: Liu
authors.forename: Jun-xian
authors.initials: JX
authors.lastname: Wang
authors.forename: Chen-jing
authors.initials: CJ
authors.lastname: Wang
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Ji
authors.forename: Xi-kuan
authors.initials: XK
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Gou
authors.forename: Tian-xia
authors.initials: TX
authors.lastname: Li
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000473:pathology / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D031828:Pyrola / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D003402:Creatine Kinase