[Pharmacokinetics of paroxetine tablet in healthy Chinese volunteers].
OBJECTIVE
To study the pharmacokinetics of paroxetine tablet in Chinese healthy volunteers.


METHODS
Twenty healthy subjects received a single oral dose of 40 mg paroxetine tablet. The plasma concentrations of paroxetine were determined using high-performance liquid chromatography (HPLC) and the measurements were analyzed with 3P97 program.


RESULTS
The plasma concentration curve of paroxetine following a single oral dose administration conformed to the two-compartment open model. The main pharmacokinetics parameters of paroxetine were: C(max)64.74-/+18.43 ng/ml, T(max)5.64-/+1.84 h, t(1/2) 20.03-/+5.33 h, AUC(0-120) 976.47-/+309.49 ng.h/ml, and AUC(0-inf) 1086.75-/+376.54 ng.h/ml.


CONCLUSIONS
The pharmacokinetics of paroxetine in human body conforms to the two-compartment open model.
Zhu
Jun
J
Department of Pharmacy, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. dropwatercat@126.com
Liu
Wei-zhong
WZ
Yang
Hong
H
Liu
Wen-xian
WX
Wang
Hua-cheng
HC
Lin
Yu-hua
YH
Liu
Yi
Y
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D017374:Paroxetine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets; D055815:Young Adult
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D013607:Tablets