title: Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States.
abstract: Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Registry Study. We calculated standardized incidence ratios (SIRs) to estimate excess risk for SCCC, primary ocular lymphoma, ocular Kaposi sarcoma (KS) and other eye tumors among 491, 048 adults (aged > 15 years or older) with HIV/AIDS diagnosed from 1980 to 2004. We calculated relative proportions (per 10(5)) to gain insight into risk factors. We identified 73 eye cancers (15 SCCC, 35 primary ocular lymphoma, 17 ocular KS and 6 other). Overall SIRs were elevated for SCCC (SIR, 12.2, 95% CI 6.8-20.2), primary ocular lymphoma (21.7, 95% CI 15.1-30.2) and ocular KS (109, 95% CI 63.5-175). Risk for SCCC was elevated regardless of HIV acquisition category, CD4 lymphocyte count and time relative to AIDS-onset. Relative proportions of SCCC risk were highest with age >or=50 (8/10(5)), Hispanic ethnicity (7/10(5)) and residence in regions with high-solar ultraviolet radiation (10/10(5)). We show significantly increased incidence of SCCC among persons with HIV/AIDS in the U.S. The associations with age and geography are in accord with etiological role for ultraviolet radiation in SCCC.
authors.affiliation: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. guechome@mail.nih.gov
authors.forename: Mercy
authors.initials: M
authors.lastname: Guech-Ongey
authors.forename: Eric A
authors.initials: EA
authors.lastname: Engels
authors.forename: James J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Biggar
authors.forename: Sam M
authors.initials: SM
authors.lastname: Mbulaiteye
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000208:ethnology / Q000821:virology*; D003230:Conjunctival Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000821:virology; D014466:Ultraviolet Rays / Q000009:adverse effects; D014481:United States / Q000453:epidemiology