title: Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroids.
abstract: Strictures are a frequent complication of eosinophilic esophagitis. The efficacy and safety of topical corticosteroids and of dilation of eosinophilic esophagitis-associated strictures have not yet been thoroughly clarified. We present a retrospective analysis of 10 adult patients with eosinophilic esophagitis who had symptomatic esophageal stenosis that was unresponsive to topical corticosteroids, and who were treated using bougienage. Eight patients had one single stricture, one patient had two, and another had three strictures; mean stricture length was 2.1 cm (range 1 - 6 cm). Bougienage led to prompt symptom relief. Apart from transient postprocedural odynophagia, no severe complications occurred. During the follow-up (mean 6 months; range 2 - 11 months), all patients enjoyed sustained treatment response.
authors.affiliation: Department of Gastroenterology, University of Bern/Inselspital, Switzerland. alain.schoepfer@insel.ch
authors.forename: A M
authors.initials: AM
authors.lastname: Schoepfer
authors.forename: J
authors.initials: J
authors.lastname: Gschossmann
authors.forename: U
authors.initials: U
authors.lastname: Scheurer
authors.forename: F
authors.initials: F
authors.lastname: Seibold
authors.forename: A
authors.initials: A
authors.lastname: Straumann
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002404:Catheterization / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004802:Eosinophilia / Q000150:complications*; D004940:Esophageal Stenosis / Q000209:etiology / Q000628:therapy*; D004941:Esophagitis / Q000150:complications*; D004945:Esophagoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017211:Treatment Failure
chemical_list: D000305:Adrenal Cortex Hormones