[Impotence caused by Methotrexate treatment].
Methotrexate (MTX) is used in the treatment of malignant and non-malignant diseases. This case report describes impotence as a seldom but possible overlooked adverse effect to MTX treatment. A 58 year-old man was treated for erythrodermia with a weekly dose of 7.5 mg MTX. He developed erective impotence nine months after initiation of treatment. Two weeks after discontinuation of MTX the impotence subsided, but when MTX treatment was reintroduced, the impotence returned after two months. Only a few other cases of impotence associated with MTX have been described previously.
Penninga
Elisabeth I
EI
Klinisk Farmakologisk Enhed, Bispebjerg Hospital, DK-2400 København NV. ip08@bbh.hosp.dk.
Larsen
Helle Kiellberg
HK
Andersen
Stig Ejdrup
SE
D003873:Dermatitis, Exfoliative / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D003879:Dermatologic Agents; D008727:Methotrexate