title: Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial.
abstract: OBJECTIVE
  The majority of endometrial cancer survivors (ECS) are obese and at risk for premature death. The purpose of this study was to assess feasibility of a lifestyle intervention program for promoting weight loss, change in eating behaviors, and increased physical activity in obese ECS.
  
  
  METHODS
  Early stage ECS (n=45) were randomized to a 6-month lifestyle intervention (LI; n=23) or usual care (UC; n=22). The LI group received group and individual counseling for 6 months. The primary endpoint was weight change. Secondary endpoints were physical activity, [Leisure score index (LSI)] and nutrient intake (3-day food records). Quantitative vitamin C and folate intake were used to assess fruit/vegetable intake.
  
  
  RESULTS
  Recruitment was 29%, adherence (LI group) was 73% and 84% of participants completed follow-up assessments. At 12 months, the intervention group lost 3.5 kg compared to a 1.4 kg gain in the control group [mean difference=-4.9 kg; 95% CI: -9.0 to -0.9 kg; p=.018] and had an increased LSI score of 16.4 versus -1.3 in the control group from baseline [mean group difference=17.8; 95% CI=7.1 to 28.4; p=.002]. There were no differences in vitamin C and folate intake. The LI group had lower intake of kilocalories, although differences were not significant.
  
  
  CONCLUSIONS
  A lifestyle intervention program in obese ECS is feasible and can result in sustained behavior change and weight loss over a 1-year period.
authors.affiliation: University Hospitals Case Medical Center, Division of Gynecologic Oncology, 11100 Euclid Avenue, Room 7128, Cleveland, Ohio 44106, USA. vivian.vongruenigen@UHhospitals.org
authors.forename: Vivian E
authors.initials: VE
authors.lastname: von Gruenigen
authors.forename: Kerry S
authors.initials: KS
authors.lastname: Courneya
authors.forename: Heidi E
authors.initials: HE
authors.lastname: Gibbons
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Kavanagh
authors.forename: Steven E
authors.initials: SE
authors.lastname: Waggoner
authors.forename: Edith
authors.initials: E
authors.lastname: Lerner
mesh_terms: D004032:Diet; D004435:Eating; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D009367:Neoplasm Staging; D015596:Nutrition Assessment; D009765:Obesity / Q000150:complications / Q000628:therapy*; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D015431:Weight Loss