Shape optimization and characterization of polysaccharide beads prepared by ionotropic gelation.
The shape of drug loaded polysaccharide beads produced by ionotropic gelation has been optimized, with the aim of producing spherical beads suitable for further technological operations, such as coating. The optimization was performed on a model system sodium alginate/theophylline by inclusion of various fillers. Incorporation of excipients markedly influenced the morphological characteristics of the beads. The undesired irregular shape of beads caused by incorporation of the drug could only be improved by incorporating a combination of polycarbophil (PK) and polyvinylpyrrolidone (PVP). The spherical shape of these beads was stabilized mechanically by numerous air bubbles trapped inside the beads, which prevented the collapse of the beads during drying. The optimized method was shown to be applicable to a target system of pectin and an anti-inflammatory drug, LK-423.
Smrdel
Polona
P
Lek Pharmaceuticals d.d., Research and Development, Ljubljana, Slovenia.
Bogataj
Marija
M
Zega
Anamarija
A
Planinsek
Odon
O
Mrhar
Ales
A
D000180:Acrylic Resins / Q000737:chemistry; D000464:Alginates / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004151:Dipeptides / Q000737:chemistry*; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D005782:Gels; D010797:Phthalimides / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical; D013806:Theophylline / Q000737:chemistry
D000180:Acrylic Resins; D000464:Alginates; D004151:Dipeptides; D005079:Excipients; D005782:Gels; D010797:Phthalimides; C117773:N-(2-(2-phthalimidoethoxy)acetyl)-L-alanyl-D-glutamic acid; C030312:calcium polycarbophil; D013806:Theophylline; D011205:Povidone