[Pharmacokinetics of pueraria for intranasal on spray in rabbits].
OBJECTIVE
To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits.


METHODS
The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters.


RESULTS
The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h.


CONCLUSIONS
The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.
Lu
Yi
Y
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang
Tong
T
Tao
Jian-sheng
JS
Xu
Lian-ying
LY
D000042:Absorption; D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007529:Isoflavones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D011817:Rabbits; D013997:Time Factors
D000336:Aerosols; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C033607:puerarin