Phenobarbital-associated bone marrow aplasia: a case report and review of the literature.
We report on a 22-year-old female who developed aplastic anemia after administration of phenobarbital for 6 years. Being refractory to steroid and anti-lymphocyte serum, the patient received allogeneic stem cell transplantation, achieving complete remission. We discuss here the potential mechanisms by which phenobarbital and other anti-epileptic drugs can cause aplastic anemia and review the literature for previous case reports and epidemiological studies.
Focosi
Daniele
D
Division of Hematology, Azienda Ospedaliera Universitaria Santa Chiara, Pisa, Italy. focosi@icgeb.org
Kast
Richard Eric
RE
Benedetti
Edoardo
E
Papineschi
Federico
F
Galimberti
Sara
S
Petrini
Mario
M
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000601:surgery; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects*; D033581:Stem Cell Transplantation
D000927:Anticonvulsants; D010634:Phenobarbital