title: [Role of hypothalamic orexin in drug addiction].
abstract: Hypothalamus is considered as an important brain region regulating natural rewards. Orexin, a neuropeptide specifically expressed in hypothalamus, arrests investigators much attention for its function in drug rewards. Orexin neurons in different brain regions exert different roles in regulating reward and motivation in the addiction research: orexin neurons in perifornical area (PFA) and dorsomedial hypothalamus (DMH) are mainly concerned with activating stress system, while orexin neurons in lateral hypothalamus participate in mediating reward-related behavior through activating brain circuitry involved in reward learning. The orexin system may therefore represent a target for preventing relapse to drug seeking during protracted abstinence. And targeting orexin receptors may provide new therapeutic strategies to treat addiction.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Han
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Yun-Jing
authors.initials: YJ
authors.lastname: Bai
authors.forename: Nan
authors.initials: N
authors.lastname: Sui
mesh_terms: D006801:Humans; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000378:metabolism; D012201:Reward; D019966:Substance-Related Disorders / Q000503:physiopathology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide