[Study on anticancer effect in vivo of active fraction from Nervilia fordii].
OBJECTIVE
To determine the active fraction with anticancer effect in vivo from Nervilia fordii.


METHODS
The effective petroleum ether extract and ethyl acetate extract parts preliminary were selected in vitro, then anticancer experiments in vivo were done by S180-mice and H22-mice models.


RESULTS
Petroleum ether extract and ethyl acetate extract parts both had obvious anticancer effects to S180-mice and H22-mice, and could prolong H22-mice life. Meanwhile, they could improve the immunoloregulation of mice.


CONCLUSIONS
It is the first time that the petroleum ether extract and ethyl acetate extract of Nervilia foadii are proved to be the effective anticancer fractions in vivo. On this basis, the further studies are needed on active principles or principle group with anticancer effect and the characteristics of this effect in Nervilia foadii.
Zhen
Han-shen
HS
Guangxi College of Traditional Chinese Medicine, Nanning 530001, China. 8zhen@163.com
Zhou
Yan-yuan
YY
Yuan
Ye-fei
YF
Zhong
Zhen-guo
ZG
Liang
Chen-yan
CY
Qiu
Qin
Q
D000085:Acetates; D000473:Alkanes; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D029595:Orchidaceae / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D000085:Acetates; D000473:Alkanes; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C007650:ethyl acetate; C004544:naphtha