title: Lifetime consequences of combined maternal lead and stress.
abstract: Elevated lead (Pb) exposure and high stress both target low socio-economic status populations. Both also act on the hypothalamic-pituitary-adrenal (HPA) axis. Pb disrupts cognition through effects on the mesocorticolimbic dopamine pathway. Stress hormones act on this same pathway via the HPA axis. The fact that Pb and stress are likely interactive risk factors served as the rationale for a series of studies in our laboratory. These demonstrate that stress can modify Pb effects, that Pb can modify stress responsivity, and, notably, that Pb + stress effects can occur in the absence of an effect of either alone in rats. Furthermore, maternal only Pb exposure can permanently alter basal corticosterone levels, stress responsivity (i.e. permanent modification of HPA axis function) and brain catecholamines in offspring of both genders. Interactive effects of Pb + stress are not limited to early development: even Pb exposures initiated post-weaning alter basal corticosterone and stress responsivity. Outcomes differ in relation to gender, brain region, stressor and time of measurement, making Pb + stress interactions complex. Altered HPA axis function may serve as a mechanism for the behavioural and catecholaminergic neurotoxicity associated with Pb, as well as for the increased incidence of disease and dysfunctions associated with low socio-economic status. The permanent consequences of maternal only Pb exposure suggest that Pb screening programmes should include pregnant women at risk for elevated Pb exposure, and that stress should be considered as an additional risk factor. Pb + stress effects observed in the absence of either risk factor alone raise questions about the capacity of current hazard identification approaches to adequately identify human health risks posed by neurotoxicants.
authors.affiliation: Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. deborah_cory-slechta@urmc.rochester.edu
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Cory-Slechta
authors.forename: Miriam B
authors.initials: MB
authors.lastname: Virgolini
authors.forename: Alba
authors.initials: A
authors.lastname: Rossi-George
authors.forename: Mona
authors.initials: M
authors.lastname: Thiruchelvam
authors.forename: Renata
authors.initials: R
authors.lastname: Lisek
authors.forename: Douglas
authors.initials: D
authors.lastname: Weston
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D004785:Environmental Pollutants; D007854:Lead; D012701:Serotonin; D004298:Dopamine; D003345:Corticosterone