Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women.
OBJECTIVE
To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone.


METHODS
Prospective comparative study.


METHODS
Menopause Unit in a tertiary Hospital.


METHODS
One hundred twenty women were recruited.


METHODS
Women were assigned into a control group, HT, and tibolone group.


METHODS
Anthropometric indices, leptin levels, tissue fat percentage, total fat, and lean mass measurements were performed at baseline and after 6 months.


RESULTS
The serum leptin levels were in strong correlation with the total fat percentage and total fat mass at baseline. Untreated women had weight gain and a gradual decrease in leptin levels. Women receiving HT had significantly increased leptin levels. Women in the tibolone group, however, had a significant decrease in leptin levels accompanied by decreased total fat mass, fat percentage, and increased total lean mass. The changes in leptin levels were more pronounced in lean women.


CONCLUSIONS
Postmenopausal women tend to gain weight accompanied with a reduction in leptin concentrations. Hormone therapy administration increases leptin levels while maintaining body weight and body fat distribution, whereas tibolone use decreases leptin levels, total fat percentage, and total fat mass.
Dedeoğlu
Emine Nihan
EN
Department of Obstetrics and Gynecology, Umraniye State Hospital, Istanbul, Turkey.
Erenus
Mithat
M
Yörük
Pinar
P
D050154:Adiposity / Q000187:drug effects*; D000328:Adult; D015992:Body Mass Index; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D017698:Postmenopause; D013997:Time Factors; D016896:Treatment Outcome; D049629:Waist-Hip Ratio; D015430:Weight Gain / Q000187:drug effects*
D004966:Estrogens, Conjugated (USP); D020738:Leptin; D009652:Norpregnenes; D017258:Medroxyprogesterone Acetate; C027385:tibolone