[Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury in rats].
OBJECTIVE
To investigate the protective effect of Total Flavonoid of Herba Pyrolae(TFHP) on acute myocardial ischemic injury in rats.


METHODS
Acute myocardial ischemic models were established by i. v. injection of pituitrin and the ligation of left descending coronary artery in rats. ECG of the rat was recorded, myocardial ischemic size was evaluated, and activites of creatine phosphokinase( CK), lactate dehydrogenase (LDH) and superoxide dismutase (SOD), level of malondialdehyde (MDA) in the rat serum were determined.


RESULTS
In comparison with the model control, TFHP significantly reduced the incidence of ischemic arrhythmia induced by pituitrin, size of myocardial infarction, release of myocardial CK and LDH caused by the ligation of left descending coronary artery in rats. The primary study of action mechanism showed that TFHP decreased MDA level and increased SOD activity in the rat serum.


CONCLUSIONS
TFHP provide a protective effect on acute myocardial ischemic injury via antioxidation.
Ding
Cun-Jing
CJ
Department of Pharmacology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Liu
Jun-tian
JT
Wang
Jun-xian
JX
Wang
Chen-jing
CJ
Ji
Yuan-yuan
YY
Li
Xi-kuan
XK
Gou
Wei
W
Li
Tian-xia
TX
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000473:pathology / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D031828:Pyrola / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D003402:Creatine Kinase