Central injection of caspase inhibitors facilitates the formation of freezing behavior in rats.
We studied the effects of central administration of pancaspase inhibitor z-VAD-fmk and specific caspase 3 inhibitor z-DEVD-fmk on learning and memory in rats. The inhibitors selectively facilitated the formation of freezing behavior without modulating consolidation and retrieval of passive defense behavior in the model of conditioned freezing.
Markina
E V
EV
P K Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. markina_elena@pochta.ru
Storozheva
Z I
ZI
Yurasov
V V
VV
Sherstnev
V V
VV
D000590:Amino Acid Chloromethyl Ketones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000590:Amino Acid Chloromethyl Ketones; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D009842:Oligopeptides; C110772:benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone