Boron-substituted difluorocyclopropanes: new building blocks of gem-difluorocyclopropanes.
Cycloaddition of difluorocarbene to alkenyl boronates 3 gave boron-substituted gem-difluorocyclopropanes 2 in stereospecific fashion. Upon treatment with lithium carbenoids, cyclopropyl boronates 2 underwent one-carbon homologation to afford a variety of gem-difluorocyclopropanes in good yields.
Fujioka
Yasutaka
Y
Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
Amii
Hideki
H
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008094:Lithium / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D001896:Boron Compounds; D003521:Cyclopropanes; D006845:Hydrocarbons, Fluorinated; D008094:Lithium