title: Enzyme inhibition activities of the extracts from rhizomes of Gloriosa superba Linn (Colchicaceae).
abstract: An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was screened for enzyme inhibition activities. The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease. An outstanding inhibition on lipoxygenase was observed. The highest enzyme inhibition potency was expressed by the chloroform fraction (90%) among the tested fractions on lipoxygenase. Overall 67-90% inhibition was found for lipoxygenase, 46-69% for acetylcholinesterase and 10-33% for butyrylcholinesterase, while urease was not inhibited.
authors.affiliation: Department of Pharmacy, University of Peshawar, N. W.F.P, Pakistan. harronkhan3@yahoo.com
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
authors.forename: Iqbal
authors.initials: I
authors.lastname: Hussan
mesh_terms: D018680:Cholinergic Antagonists / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D019668:Liliaceae / Q000737:chemistry*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*
chemical_list: D018680:Cholinergic Antagonists; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase