title: Palliative chemotherapy preferences and factors that influence patient choice in incurable advanced cancer.
abstract: OBJECTIVE
  To determine the extent of informed decision-making and treatment preference of Korean patients receiving palliative chemotherapy.
  
  
  METHODS
  We assessed 138 patients (median age: 58 years; 73% male) with advanced cancer who had received at least one cycle of chemotherapy. General demographic information, the extent of information received, patient preferences for palliative chemotherapy and randomized trials were determined using structured patient interviews. We investigated the survival threshold for justifying toxicity, the factors influencing individual preference for chemotherapy and the attitude of patients towards randomized trials.
  
  
  RESULTS
  Before chemotherapy, 72.1% of patients were given information about adverse events of treatment, but only 39.5% were told of alternative treatments. There was significant inter-individual variability in willingness to accept chemotherapy, as well as a wide range of thresholds. Patients reporting higher quality of life were more likely to judge treatment as acceptable. When given the choice for randomization for conventional chemotherapy, investigational agents or supportive care, patients usually refused enrollment into randomized trials.
  
  
  CONCLUSIONS
  Self-assessed quality of life was a significant predictor of stronger preference for chemotherapy. In the palliative setting, good doctor-patient communications and consideration of patients' preferences are necessary for making decisions about proper treatment.
authors.affiliation: Division of Oncology, Department of Internal Medicine, Yeungnam University College of Medicine, 317-1 Daemyung dong, Namgu, Daegu 705-717, South Korea.
authors.forename: Min Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Jae-Lyun
authors.initials: JL
authors.lastname: Lee
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
authors.forename: Young Rok
authors.initials: YR
authors.lastname: Do
authors.forename: Hong Suk
authors.initials: HS
authors.lastname: Song
authors.forename: Jong Gwang
authors.initials: JG
authors.lastname: Kim
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Bae
authors.forename: Hun Mo
authors.initials: HM
authors.lastname: Ryoo
authors.forename: Keon Uk
authors.initials: KU
authors.lastname: Park
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002755:Choice Behavior; D003657:Decision Making; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D010166:Palliative Care / Q000523:psychology*; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D013727:Terminal Care / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents