Chronic mucocutaneous candidiasis - an immunological mystery.
Chronic mucocutaneous candidiasis (CMC) refers to a group of disorders which have in common recurrent and persistent infections of the skin, nails and mucous membranes by Candida albicans and occasionally other candida species. A proportion of these patients show an associated endocrinopathy as part of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome. Many cases, however, are not associated with endocrinopathy and demonstrate a variety of T-cell or antigen-presenting cell defects leading to abnormal cell-mediated responses to C. albicans.
Rabson
A R
AR
Tufts-New England Medical Center, Boston, USA. Arabson@tufts-nemc.org
D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications / Q000276:immunology*; D006801:Humans; D016884:Polyendocrinopathies, Autoimmune / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D013959:Thyroid Diseases / Q000150:complications; D014157:Transcription Factors / Q000235:genetics; D000096927:AIRE Protein
D014157:Transcription Factors; D000096927:AIRE Protein