Antibacterial properties of novel poly(methyl methacrylate) nanofiber containing silver nanoparticles.
Poly(methyl methacrylate) (PMMA) nanofiber containing silver nanoparticles was synthesized by radical-mediated dispersion polymerization and applied to an antibacterial agent. UV-vis spectroscopic analysis indicated that the silver nanoparticles were continually released from the polymer nanofiber in aqueous solution. The antibacterial properties of silver/PMMA nanofiber against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria were evaluated using minimum inhibitory concentration (MIC), the modified Kirby-Bauer method, and a kinetic test. The MIC test demonstrated that the silver/PMMA nanofiber had enhanced antimicrobial efficacy compared to that of silver sulfadiazine and silver nitrate at the same silver concentration.
Kong
Hyeyoung
H
College of Engineering, Seoul National University, 56-1 Shinlim Kwanak, Seoul 151-742, Korea.
Jang
Jyongsik
J
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D043942:Nanotubes / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry*; D012835:Silver Nitrate / Q000494:pharmacology; D012837:Silver Sulfadiazine / Q000494:pharmacology; D012996:Solutions; D040141:Staphylococcaceae / Q000187:drug effects*; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D012996:Solutions; D014867:Water; D012834:Silver; D019904:Polymethyl Methacrylate; D012835:Silver Nitrate; D012837:Silver Sulfadiazine