Dubbing SAGA unveils new epigenetic crosstalk.
In a recent issue of Molecular Cell, two independent studies (Zhang et al., 2008; Zhao et al., 2008) provide compelling evidence that targeted deubiquitylation of histones is intimately linked to transcription activation, epigenetic regulation, and cancer progression.
Pijnappel
W W M Pim
WW
Department of Physiological Chemistry, STR3.201, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands.
Timmers
H Th Marc
HT
D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D002460:Cell Line; D017124:Conserved Sequence; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D051548:Histone Acetyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D025941:Protein Interaction Mapping; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013869:Thiolester Hydrolases / Q000737:chemistry / Q000502:physiology; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D035165:Transcription Factors, General / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D043222:Ubiquitin Thiolesterase; D054875:Ubiquitination / Q000502:physiology*; D050880:p300-CBP Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000099224:p300-CBP-Associated Factor
D029721:Drosophila Proteins; D010450:Endopeptidases; D006570:Heterochromatin; D051548:Histone Acetyltransferases; D046912:Multiprotein Complexes; D012319:RNA Polymerase II; D011944:Receptors, Androgen; D011993:Recombinant Fusion Proteins; D013869:Thiolester Hydrolases; D015534:Trans-Activators; D014157:Transcription Factors; D035165:Transcription Factors, General; D043222:Ubiquitin Thiolesterase; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C527169:ATXN7L3 protein, human; C527171:Eny2 protein, human; C527172:Sgf11 protein, Drosophila; C423782:e(y)2 protein, Drosophila; C421164:not protein, Drosophila; C527170:Usp22 protein, human