title: Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.
abstract: Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The beta-diketone moiety renders curcumin to be rapidly metabolized by aldo-keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.
authors.affiliation: College of Pharmacy, Wenzhou Medical College, Wenzhou, Zhejiang 325035, PR China.
authors.forename: Guang
authors.initials: G
authors.lastname: Liang
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Shulin
authors.initials: S
authors.lastname: Yang
authors.forename: Xudong
authors.initials: X
authors.lastname: Wu
authors.forename: Elaine
authors.initials: E
authors.lastname: Studer
authors.forename: Emily
authors.initials: E
authors.lastname: Gurley
authors.forename: Phillip B
authors.initials: PB
authors.lastname: Hylemon
authors.forename: Faqing
authors.initials: F
authors.lastname: Ye
authors.forename: Yueru
authors.initials: Y
authors.lastname: Li
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D003512:Cyclohexanones / Q000138:chemical synthesis / Q000494:pharmacology; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003512:Cyclohexanones; D003517:Cyclopentanes; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C007201:cyclopentanone; D003474:Curcumin