title: RNA interference: a multifaceted innate antiviral defense.
abstract: The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defenses, as well as the full physiological implication of host-pathogen engagement, constitute exciting areas of investigation in the biology of non-coding RNAs.
authors.forename: Ajit
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D035683:MicroRNAs