Natural dental caries in molars of osteogenic disorder Shionogi rats.
Osteogenic disorder Shionogi (ODS) rats are genetically defective in ascorbic acid biosynthesis. They exhibit a gait abnormality due to dysfunctional bone formation and display various dental abnormalities. Conditions of the oral cavity and tooth quality both influence the development of dental caries. This study was designed to determine the characteristics of dental caries in ODS/ ShiJclod/od rats. Caries were scored and compared among ODS/ShiJclod/od, ODS/ShiJcl+/+, and Jcl:Wistar retired breeders. Among male rats, the caries scores of the ODS/ShiJclod/od and ODS/ShiJcl+/+ groups were similar to each other but greater than those in Jcl:Wistar rats, whereas among female rats, caries scores in ODS/ShiJclod/od animals were equivalent to or somewhat greater than those in ODS/ShiJcl+/+ rats, whose scores were markedly greater than those of Jcl:Wistar rats. The results suggest that ODS/ShiJcl rats were more susceptible to dental caries than were Jcl:Wistar rats. Under the conditions of the study, caries scores between ODS/ ShiJclod/od and ODS/ShiJcl+/+ rats differed only among parous females.
Nishijima
Kazutoshi
K
Animal Facility for Aging Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology. kazz@nils.go.jp
Kuwahara
Sachi
S
Ohno
Tamio
T
Miyaishi
Osamu
O
Ito
Yoshitake
Y
Makino
Susumu
S
Sumi
Yasunori
Y
Tanaka
Shin
S
D000818:Animals; D001205:Ascorbic Acid / Q000096:biosynthesis; D001851:Bone Diseases, Metabolic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003731:Dental Caries / Q000235:genetics* / Q000473:pathology; D005260:Female; D008297:Male; D008963:Molar / Q000473:pathology; D010012:Osteogenesis / Q000235:genetics*; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar
D001205:Ascorbic Acid