title: Copper-catalyzed synthesis of enantioenriched tetraarylethanes.
abstract: Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.
authors.affiliation: Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wendy_jen@merck.com
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Jen
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Truppo
authors.forename: Deborah
authors.initials: D
authors.lastname: Amos
authors.forename: Paul
authors.initials: P
authors.lastname: Devine
authors.forename: Michael
authors.initials: M
authors.lastname: McNevin
authors.forename: Mirlinda
authors.initials: M
authors.lastname: Biba
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Campos
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004980:Ethane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; D003300:Copper; D004980:Ethane