[Stem-cell-based approaches for treating inner ear diseases].
The capacity of stem cells to regenerate lost tissue cells has gained recognition among physicians. Despite the successful use of blood stem cells for treating blood cancers, other stem cell types have not yet been widely introduced into clinical practice. Therapy options involving stem cells for inner ear diseases consequently have not been implemented. Nonetheless, several reports have recently been published describing the generation of morphologically and immunologically distinctive inner ear cell types-such as hair cells, supporting cells, and spiral ganglion neurons-from stem cells. Although promising, all of these studies still lack functional results regarding hearing restoration or vestibular function.
Senn
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P
Universitätsklinik für Hals- Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Inselspital, 3010, Bern, Schweiz. pascal.senn@insel.ch
Heller
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S
D007758:Ear, Inner / Q000473:pathology*; D005858:Germany; D006311:Hearing Disorders / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007759:Labyrinth Diseases / Q000473:pathology* / Q000601:surgery*; D008954:Models, Biological; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000639:trends*