title: Papillary carcinoma with nodular fasciitis-like stroma--a case report in pregnancy.
abstract: We report a case of Papillary carcinoma with nodular fasciitis-like stroma that is a rare variant of Papillary carcinoma characterized by a prominent stromal cell proliferation that causes difficulties in cytologic and histologic diagnosis. The patient was a 34-year-old woman, pregnant, presented with a 1-year history of a growing mass in neck, dysphagia, and hoarseness. Physical examination revealed a firm nodular mass in thyroid gland. The fine needle aspiration biopsy specimen contained, besides diagnostic epithelial features of Papillary thyroid carcinoma, discohesive arrangement of bland spindle cells. Macroscopically, the specimen consisted of nodular tumor measuring 10 x 6 x 6 cm. Histologically the tumor was composed of small foci of neoplastic epithelial component distributed in abundant stroma. In immunohistochemistry, spindle cells in the stroma were positive for alpha-smooth muscle actin and the neoplastic cells showed positive staining for TTF-1 and progesterone receptor.
authors.affiliation: Department of Pathology, Asa Norte Hospital, Brasília, DF, Brazil. isabelirl1@yahoo.com.br
authors.forename: Isabel Irene Rama
authors.initials: II
authors.lastname: Leal
authors.forename: Fabiana Pirani
authors.initials: FP
authors.lastname: Carneiro
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Basílio-de-Oliveira
authors.forename: Albino Verçosa
authors.initials: AV
authors.lastname: Magalhães
authors.forename: Tânia Wanderley Paes
authors.initials: TW
authors.lastname: Barbosa
authors.forename: Francileide Paes
authors.initials: FP
authors.lastname: da Silva
authors.forename: Frederico Sérgio Luis
authors.initials: FS
authors.lastname: de Castro Montenegro
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005208:Fasciitis / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011980:Receptors, Progesterone / Q000032:analysis; D017154:Stromal Cells / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D011980:Receptors, Progesterone