title: Conjunctival involvement in chronic recurrent multifocal osteomyelitis.
abstract: OBJECTIVE
  To report a case of chronic recurrent multifocal osteomyelitis (CRMO) with conjunctival involvement.
  
  
  METHODS
  Retrospective chart review.
  
  
  RESULTS
  A 10-year-old girl who complained of fatigue and debilitating pain in both hips and legs for >1 year had recurrent episodes of redness and discharge in both eyes with little response to different topical medications. The diagnosis of CRMO was confirmed with the help of magnetic resonance imaging, bone scan, and bone biopsy results. She had moderate hyperemia and multiple discrete salmon-colored lesions in both palpebral and fornical conjunctivae. Biopsy revealed chronic inflammatory infiltration composed predominantly of lymphocytes forming a follicular pattern. Conjunctival lesions worsened during relapses of skeletal symptoms, improved during remission, and resolved shortly after the initiation of oral prednisolone therapy. No recurrence was observed during 16 months of follow-up.
  
  
  CONCLUSIONS
  Salmon-colored conjunctival lesions may accompany CRMO and respond favorably to systemic steroid therapy.
authors.affiliation: Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey. zeynep_ozbek@hotmail.com
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ozbek
authors.forename: Balahan
authors.initials: B
authors.lastname: Makay
authors.forename: Erbil
authors.initials: E
authors.lastname: Unsal
authors.forename: Ismet
authors.initials: I
authors.lastname: Durak
authors.forename: Dilek
authors.initials: D
authors.lastname: Gunes
authors.forename: Ozden
authors.initials: O
authors.lastname: Anal
authors.forename: Erdener
authors.initials: E
authors.lastname: Ozer
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D003229:Conjunctival Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D012460:Sulfasalazine / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D012460:Sulfasalazine; D011239:Prednisolone; D008727:Methotrexate