title: Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.
abstract: BACKGROUND
  The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.
  
  
  OBJECTIVE
  Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.
  
  
  METHODS
  This is a clinical case report from the Clinical Research Center of the National Institutes of Health.
  
  
  METHODS
  One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.
  
  
  RESULTS
  The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.
  
  
  CONCLUSIONS
  A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
authors.affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Maya B
authors.initials: MB
authors.lastname: Lodish
authors.forename: Anathea C
authors.initials: AC
authors.lastname: Powell
authors.forename: Mones
authors.initials: M
authors.lastname: Abu-Asab
authors.forename: Craig
authors.initials: C
authors.lastname: Cochran
authors.forename: Petra
authors.initials: P
authors.lastname: Lenz
authors.forename: Steven K
authors.initials: SK
authors.lastname: Libutti
authors.forename: James F
authors.initials: JF
authors.lastname: Pingpank
authors.forename: Maria
authors.initials: M
authors.lastname: Tsokos
authors.forename: Phillip
authors.initials: P
authors.lastname: Gorden
mesh_terms: D000293:Adolescent; D005260:Female; D015408:Gastrinoma / Q000209:etiology*; D005755:Gastrins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000209:etiology*; D018358:Neuroendocrine Tumors / Q000378:metabolism* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000378:metabolism*; D013577:Syndrome
chemical_list: D005755:Gastrins; D007328:Insulin