Antithrombotic activity of heparin-ATP complex.
The complex of high-molecular-weight heparin and ATP prevented thrombus formation in the blood flow. Repeated intramuscular injection of the complex increased total fibrinolytic activity of the blood, nonenzymatic fibrinolysis, and plasma anticoagulant activity and significantly decreased platelet aggregation.
Obergan
T Yu
TY
B. A. Kudryashov Laboratory of Blood Defense Systems, Biological Faculty, M. V. Lomonosov Moscow State University.
Lyapina
L A
LA
Pastorova
V E
VE
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007273:Injections, Intramuscular; D046911:Macromolecular Substances; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control
D005343:Fibrinolytic Agents; D046911:Macromolecular Substances; D000255:Adenosine Triphosphate; D006493:Heparin