PTP1B and TC-PTP: regulators of transformation and tumorigenesis.
PTP1B and T cell PTP (TC-PTP) are protein tyrosine phosphatases (PTPs) that share high sequence and structural homology yet play distinct physiological roles. While PTP1B plays a central role in metabolism and is an attractive drug target for obesity and type 2 diabetes, TC-PTP is necessary for the control of inflammation. In this review, we will discuss the growing evidence for the involvement of PTP1B in cancer, while proposing a role for TC-PTP in inflammation-induced tumorigenesis. Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models.
Stuible
Matthew
M
McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, QC, Canada.
Doody
Karen M
KM
Tremblay
Michel L
ML
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D009369:Neoplasms / Q000201:enzymology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000502:physiology*; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000502:physiology*
C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2