Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.
Following our previous studies in the field of anticonvulsant agents, we planned a one-pot solution-phase parallel synthesis (SPPS) of a small library of new 1,2,3,4-tetrahydroisoquinoline derivatives. The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated.
Gitto
Rosaria
R
Department of Medicinal Chemistry, Faculty of Pharmacy, Università di Messina, Messina, Italy. rgitto@pharma.unime.it
Francica
Eleonora
E
De Sarro
Giovambattista
G
Scicchitano
Francesca
F
Chimirri
Alba
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D020195:Epilepsy, Reflex / Q000517:prevention & control; D005260:Female; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012996:Solutions; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000927:Anticonvulsants; D007202:Indicators and Reagents; D012996:Solutions; D044005:Tetrahydroisoquinolines