title: Circulating calprotectin in ovarian carcinomas and borderline tumors of the ovary.
abstract: OBJECTIVE
  Recent studies indicate that circulating calprotectin may serve as a biomarker in some cancers. We investigated whether this is the case for ovarian neoplasms.
  
  
  METHODS
  Calprotectin was analyzed with an enzyme-linked immunosorbent assay in EDTA-plasma collected prior to surgery from women with ovarian carcinomas (n = 89), borderline ovarian tumors (BOT, n = 39), and benign ovarian tumors (n = 71). Serum CA 125 was analyzed in the same study population.
  
  
  RESULTS
  Median plasma calprotectin concentration was elevated in ovarian carcinoma, compared with controls, as well as compared with BOT (both P < .001). A positive correlation was found between CA 125 and calprotectin concentrations in ovarian carcinoma. Receiver operating characteristic curves demonstrated a larger area under the curve for CA 125 (0.85) as compared with calprotectin (0.70).
  
  
  CONCLUSIONS
  Plasma calprotectin is elevated in invasive ovarian cancer, but when used as a tumor marker, it is inferior to CA 125.
authors.affiliation: Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway.
authors.forename: Elin
authors.initials: E
authors.lastname: Ødegaard
authors.forename: Ben
authors.initials: B
authors.lastname: Davidson
authors.forename: Bente Vilming
authors.initials: BV
authors.lastname: Elgaaen
authors.forename: Magne K
authors.initials: MK
authors.lastname: Fagerhol
authors.forename: Vibeke
authors.initials: V
authors.lastname: Engh
authors.forename: Mathias
authors.initials: M
authors.lastname: Onsrud
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D039841:Leukocyte L1 Antigen Complex