Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry.
This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions.
Baker
Matthew J
MJ
Manchester Interdisciplinary Biocentre, Centre for Instrumentation and Analytical Science, School of Chemical Engineering and Analytical Science, The University of Manchester, UK. M.Baker-2@postgrad.manchester.ac.uk
Brown
Michael D
MD
Gazi
Ehsan
E
Clarke
Noel W
NW
Vickerman
John C
JC
Lockyer
Nicholas P
NP
D045744:Cell Line, Tumor; D016002:Discriminant Analysis; D006801:Humans; D008297:Male; D025341:Principal Component Analysis / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods*