Effects of phenol, glycerin and acetic acid on the liver of guinea pigs.
OBJECTIVE
To investigate the histolytic action of a solution composed of phenol, glycerin and acetic acid for irresectable hepatic metastasis.


METHODS
Thirty-two (n=32) guinea pigs were randomly distributed into two groups of 16 animals. The animals in group 1 (experimental) and group 2 (control) were redistributed in two subgroups of eight animals each, according to the day of sacrifice (24 hours and four weeks after injection). All the animals were submitted to median laparotomy, which was followed by the injection of solution E and saline into the livers of subjects in both the experimental and control groups, respectively. The animals were evaluated for biochemical and anatomopathological (liver) alterations after 24 hours and four weeks of the experiment.


RESULTS
It was observed that solution E produced necrosis limited to the injected area and that hepatic tissue recovery occurred after four weeks with the formation of a small necrosis area. No biochemical parameters were altered either in the experimental or in the control group.


CONCLUSIONS
In view of the obtained results, the possibility of using the proposed solution can be considered in cases of irresectable metastasis.
Saad-Hossne
Rogério
R
Department of Surgery, Botucatu School of Medicine, UNESP, Brazil. saad@fmb.unesp.br
Hossne
William Saad
WS
Montenegro
Mario Rubens Guimarães
MR
D019342:Acetic Acid / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009336:Necrosis; D019800:Phenol / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
D019800:Phenol; D005990:Glycerol; D019342:Acetic Acid