Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides.
Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes (primarily of the Th2 type). The risk of progression and chronic course of viral hepatitides in Caucasian population was associated with alleles of promoter regions -330G and -592A in the IL-2 and IL-10 genes, respectively, as well as with the T/T genotype of the polymorphic region C590T in the IL-4 gene. The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses.
Naslednikova
I O
IO
Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk. ira_naslednikova@mail.ru
Konenkov
V I
VI
Ryazantseva
N V
NV
Novitskii
V V
VV
Tkachenko
S B
SB
Zima
A P
AP
Avdoshina
V V
VV
Beloborodova
E I
EI
Beloborodova
E V
EV
Dortman
V V
VV
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D019694:Hepatitis B, Chronic / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000235:genetics; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged
C508609:IL10 protein, human; C508598:IL4 protein, human; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4