title: The genetics of anorexia nervosa collaborative study: methods and sample description.
abstract: OBJECTIVE
  Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN).
  
  
  METHODS
  Four hundred families will be ascertained with two or more individuals affected with AN. The assessment battery produces a rich set of phenotypes comprising eating disorder diagnoses and psychological and personality features known to be associated with vulnerability to eating disorders.
  
  
  RESULTS
  We report attributes of the first 200 families, comprising 200 probands and 232 affected relatives.
  
  
  CONCLUSIONS
  These results provide context for the genotyping of the first 200 families by the Center for Inherited Disease Research. We will analyze our first 200 families for linkage, complete recruitment of roughly 400 families, and then perform final linkage analyses on the complete cohort. DNA, genotypes, and phenotypes will form a national eating disorder repository maintained by NIMH and available to qualified investigators.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
authors.forename: Katherine
authors.initials: K
authors.lastname: Plotnicov
authors.forename: Laura
authors.initials: L
authors.lastname: Thornton
authors.forename: Bernie
authors.initials: B
authors.lastname: Devlin
authors.forename: Manfred M
authors.initials: MM
authors.lastname: Fichter
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: Allan
authors.initials: A
authors.lastname: Kaplan
authors.forename: D Blake
authors.initials: DB
authors.lastname: Woodside
authors.forename: Craig L
authors.initials: CL
authors.lastname: Johnson
authors.forename: Katherine
authors.initials: K
authors.lastname: Halmi
authors.forename: Harry A
authors.initials: HA
authors.lastname: Brandt
authors.forename: Steve
authors.initials: S
authors.lastname: Crawford
authors.forename: James E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: Wade
authors.initials: W
authors.lastname: Berrettini
authors.forename: Ian
authors.initials: I
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000856:Anorexia Nervosa / Q000235:genetics*; D002648:Child; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors