title: Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people.
abstract: BACKGROUND
  Nursing homes for older people provide an environment likely to promote the acquisition and spread of meticillin-resistant Staphylococcus aureus (MRSA), putting residents at increased risk of colonisation and infection. It is recognised that infection control strategies are important in preventing and controlling MRSA transmission.
  
  
  OBJECTIVE
  The objective of this review was to determine the effects of infection control strategies for preventing the transmission of MRSA in nursing homes for older people.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2007, Issue 1), the Cochrane Wounds Group Specialised Register (searched April 2007); the Infectious Diseases Group and EPOC also searched their Specialised Registers for this review (both May 2006). We also searched MEDLINE (from 1966 to March Week 3 2007), EMBASE (1980 to 2007 Week 13), CINAHL (1982 to March Week 3 2007), British Nursing Index (1985 to March 2007), DARE (1992 to March 2007), Web of Science (1981 to March 2007), and the Health Technology Assessment (HTA) database (1988 to March 2007). Research in progress was identified through the National Research Register, Current Clinical Trials (www.controlled-trials.com), Medical Research Council Register, Current Research in Britain (CRIB), and HSRPRoj (current USA projects). SIGLE was also searched in order to identify atypical material which was not accessible through more conventional sources.
  
  
  METHODS
  All randomised and controlled clinical trials, controlled before and after studies and interrupted time series studies of infection control interventions in nursing homes for older people were eligible for inclusion.
  
  
  METHODS
  Two authors independently reviewed the results of the searches.
  
  
  RESULTS
  Since no studies met the selection criteria, neither a meta-analysis nor a narrative description of studies was possible.
  
  
  CONCLUSIONS
  The lack of studies in this field is surprising. Nursing homes for older people provide an environment likely to promote the acquisition and spread of infection, with observational studies repeatedly reporting that being a resident of a nursing home increases the risk of MRSA colonisation. Much of the evidence for recently-issued United Kingdom guidelines for the control and prevention of MRSA in health care facilities was generated in the acute care setting. It may not be possible to transfer such strategies directly to the nursing home environment, which serves as both a healthcare setting and a resident's home. Rigorous studies should be conducted in nursing homes, to test interventions that have been specifically designed for this unique environment.
authors.affiliation: Queen's University Belfast, School of Pharmacy, 97 Lisburn Road, Belfast, Northern Ireland, UK, BT9 7BL. c.hughes@qub.ac.uk
authors.forename: C M
authors.initials: CM
authors.lastname: Hughes
authors.forename: M B H
authors.initials: MB
authors.lastname: Smith
authors.forename: M M
authors.initials: MM
authors.lastname: Tunney
mesh_terms: D000368:Aged; D003428:Cross Infection / Q000517:prevention & control / Q000635:transmission; D006707:Homes for the Aged; D006801:Humans; D017053:Infection Control / Q000379:methods*; D016106:Methicillin Resistance; D009735:Nursing Homes; D013203:Staphylococcal Infections / Q000517:prevention & control* / Q000635:transmission; D013211:Staphylococcus aureus / Q000187:drug effects*