title: Hyperzincaemia in a pet African giant rat (Cricetomys gambianus Waterhouse, 1840).
abstract: Presented is an African giant rat (Cricetomys gambianus) following zinc ingestion. The sick rat was lethargic, withdrawn, had soft, mucus-impregnated faeces and diahorrea, foot twitching and icterus. Comparative age, sex and body weight (b.wt.)-matched analyses were made with a healthy giant rat. Twelve-hourly Urine volume (UV), Haematocrit (Hct), urinary glucose, plasma zinc and Alkaline Phosphatase (ALP) were performed over an 8-week period. Full blood counts were performed and differential WBC counts and microscopic observations were made on blood smears obtained from both healthy and sick rats. Consecutive blood samples were drawn at the end of each week (Weeks <2-6 treatment; Weeks 7-8 post-treatment). Treatment involved oral vitamin B12 supplement at 4 microg/day and 2 ml diethylenetriaminepentaacetic acid (DTPA) intramuscular injections at 1 ml/450g b.wt./5 wks (Week 2 - 6). Day 1 showed neutropaenia, Heinz bodies on RBCs (reticulocytes and immature forms). Zinc (Day 1 - end Week 7), glucose (Day 1 - end Week 4), ALP (Day 1 -Week 4) and UV were elevated (Day 1 - end Week 6). Indications of moderate zinc toxicosis following ingestion and stress-associated glucosuria were concluded.
authors.affiliation: Department of Physiology, College of Health Sciences, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe, Africa. rgcooperuk@yahoo.com
authors.forename: R G
authors.initials: RG
authors.lastname: Cooper
authors.forename: K H
authors.initials: KH
authors.lastname: Erlwanger
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D006029:Glycosuria / Q000662:veterinary; D004369:Pentetic Acid / Q000627:therapeutic use; D051381:Rats; D012376:Rodent Diseases / Q000097:blood* / Q000188:drug therapy; D016896:Treatment Outcome; D016482:Urinalysis / Q000662:veterinary; D014805:Vitamin B 12 / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*; D015032:Zinc / Q000097:blood* / Q000506:poisoning*
chemical_list: D002614:Chelating Agents; D014803:Vitamin B Complex; D004369:Pentetic Acid; D015032:Zinc; D014805:Vitamin B 12