title: Clinicopathological risk factors linked to recurrence pattern after curative hepatic resection for hepatocellular carcinoma--results of 152 resected cases.
abstract: OBJECTIVE
  The recurrence rate after hepatectomy of hepatocellular carcinoma (HCC) remains high. Although the cause of recurrence seems to be the multicentric occurrence and metastasis of cancer cells in the patients after curative resection of HCC, the mechanism of HCC recurrence in each case is still uncertain. The recurrence pattern may illuminate these mechanisms.
  
  
  METHODS
  A data analysis of 152 patients who underwent HCC resection, and had observed for more than 5 years was conducted. These patients were divided into three groups; group I (n=32), the patients without HCC recurrence, group II (n=86), the patients with fewer than four recurrent nodules of HCC, group III (n=34), the patients with four or more recurrent nodules of HCC. We compared the clinicopathological data of groups I and II, and of groups I and III. The linkage of risk factors linked to recurrence patterns was clarified.
  
  
  RESULTS
  The risk factors linked to group II by comparison with group I were high serum levels of alanine aminotransferase, low serum levels of albumin, high values in the indocyanine green retention test at fifteen minutes, hepatitis C antibody positivity. low platelet counts, and high histological hepatitis activity. The risk factors linked to group III were large tumor size, histological presence of portal vein invasion by cancer cells, intrahepatic metastasis, and poor differentiation of cancer cells.
  
  
  CONCLUSIONS
  The risk factors linked to recurrence with no more than three HCC nodules recurrence were related to host-related factors such as hepatic function, and hepatitis activity, but not tumor related. The risk factors linked to multiple recurrence were tumor related. The analysis of recurrence patterns revealed that completely different mechanisms exist in the patients with recurrence involving no more than four nodules, which may be related to multicentric occurrence, and patients with multiple recurrence, which may be related to the metastasis of cancer cells.
authors.affiliation: Department of Hepato-Gastroenterological Surgery, Aso Iizuka Hospital, Iizuka City, Fukuoka 820-8505, Japan. kshirabeh1@aih-net.com
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Wakiyama
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Gion
authors.forename: Kenta
authors.initials: K
authors.lastname: Motomura
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Koyanagi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaie
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D018570:Risk Assessment; D012307:Risk Factors