[Clinical features and treatment of invasive fungal infection in 47 patients with hematological malignancies].
OBJECTIVE
To analyze the clinical features of invasive fungal infection in patients with hematological malignancies and to compare the the therapeutic effect of fluconazole and intraconazole.


METHODS
The clinical manifestations, mycological features, and the therapeutic results of 47 patients were retrospectively analyzed. Fluconazole was given to 17 paitents, intraconazole was given to 21 patients, and intraconazole to the other 9 patients after they had no effect with fluconazole.


RESULTS
All patients had fever. The lung and the mouth cavity were the main locations of infection (53.2% and 21.3%, respectively). Fungi were found in 23 (48.9%) patients, in which the majority were Candida albicans and Aspergillus (56.5% and 26.1%, respectively). Intraconazole was more effective than fluconazole (63.3% vs. 34.6%, P<0.05) with no serious side effect.


CONCLUSIONS
The most common clinical features of IFI are fever, lung infection, and oral infection in patients with hematological malignancies. Candida albicans and Aspergillus infection are common. Intraconazole is safe and effective for invasive fungal infection.
Zhu
Yan
Y
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China. zhuyanlq@hotmail.com
Chen
Shu-ping
SP
Shu
Yi-gang
YG
Xu
Ya-jing
YJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole