title: Cancer chemopreventive activity of terpenoid coumarins from Ferula species.
abstract: Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV-EA activation and preserved the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents (IC (50) 8.3 and 9.1 nM, respectively). Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids.
authors.affiliation: Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Iranshahim@mums.ac.ir
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
authors.forename: Farhad
authors.initials: F
authors.lastname: Kalategi
authors.forename: Ramin
authors.initials: R
authors.lastname: Rezaee
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Shahverdi
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D005309:Ferula / Q000737:chemistry*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D003374:Coumarins; D010936:Plant Extracts; D013729:Terpenes