[Non invasive fetal RhD genotyping using maternal blood: time for use in all RhD negative pregnant women].
Non invasive fetal RhD genotyping, based on polymerase-chain-reaction (PCR), is an accurate and validated technique. It allows a reduction by one-third of anti-D immunoglobulin injections to prevent RhD allo-immunization. In case of maternal anti-D immunization, fetal RhD genotyping allows to focus on RhD positive fetuses only the biologic and sonographic follow-up. The wide use of this technique implies the validation and economic evaluation of a commercial RhD genotyping kit, ready for use in non specialized laboratories.
Carbonne
B
B
Service de gynécologie-obstétrique, centre national de référence en hémobiologie périnatale (CNRHP), hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France. Electronic address: bruno.carbonne@sat.aphp.fr.
Cortey
A
A
Service de gynécologie-obstétrique, centre national de référence en hémobiologie périnatale (CNRHP), hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
Rouillac-Le Sciellour
C
C
Service de gynécologie-obstétrique, centre national de référence en hémobiologie périnatale (CNRHP), hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
Brossard
Y
Y
Service de gynécologie-obstétrique, centre national de référence en hémobiologie périnatale (CNRHP), hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008431:Maternal-Fetal Exchange; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000235:genetics*
D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen