title: Study of drotaverine on first stage of labour and pregnancy outcome.
abstract: A prospective randomised study of 200 women with spontaneous onset of labour was carried out in 100 women who were given 40mg of drotaverine hydrochloride intravenously at > or = 3cm dilatation of the cervix, the other 100 were taken as control. The effects of the drug on the progress and outcome of labour were noted. The mean durations of active phase of labour in primigravida and multigravida were 148.9 minutes and 99.5 minutes in drotaverine group whereas in control group were 331.6 minutes and 227.9 minutes respectively. It was concluded that drotaverine is highly effective in reducing the duration of active phase of labour by hastening cervical dilatation, more effective when given in more dilated cervix than with less dilatation and more effective in multigravida than in primigravida. There was no interference with uterine contractility and no increase in operative delivery. It reduces the incidence of traumatic postpartum haemorrhage by reducing the incidence of cervical tear. It is a safe drug for the mother as well as for the baby.
authors.affiliation: Department of Obstetrics and Gynaecology, RG Kar Medical College and Hospital, Kolkata 700004.
authors.forename: Anita
authors.initials: A
authors.lastname: Roy
authors.forename: Kajal Kumar
authors.initials: KK
authors.lastname: Patra
authors.forename: Sima
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Guha
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007745:Labor Onset / Q000187:drug effects; D007747:Labor Stage, First / Q000187:drug effects*; D007743:Labor, Obstetric; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies
chemical_list: D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; C005317:drotaverin; D010208:Papaverine