Magnetic force microscopy of superparamagnetic nanoparticles.
The use of magnetic force microscopy (MFM) to detect probe-sample interactions from superparamagnetic nanoparticles in vitro in ambient atmospheric conditions is reported here. By using both magnetic and nonmagnetic probes in dynamic lift-mode imaging and by controlling the direction and magnitude of the external magnetic field applied to the samples, it is possible to detect and identify the presence of superparamagnetic nanoparticles. The experimental results shown here are in agreement with the estimated sensitivity of the MFM technique. The potential and challenges for localizing nanoscale magnetic domains in biological samples is discussed.
Schreiber
Sharon
S
Biomedical Engineering Department, Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA.
Savla
Mayur
M
Pelekhov
Denis V
DV
Iscru
Daniel F
DF
Selcu
Camelia
C
Hammel
P Chris
PC
Agarwal
Gunjan
G
D052203:Ferrosoferric Oxide / Q000737:chemistry; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force / Q000379:methods* / Q000706:statistics & numerical data; D010316:Particle Size
D052203:Ferrosoferric Oxide