title: Hysteroscopy in endometrial cancer: new methods to evaluate transtubal leakage of saline distension medium.
abstract: OBJECTIVE
  This study was undertaken to evaluate transtubal fluid leakage after low pressure office saline solution hysteroscopy.
  
  
  METHODS
  Forty stage I/II endometrial cancer patients were submitted to office hysteroscopy at the National Cancer Institute of Milan. Uterine cavity was distended by a 1000-mL saline solution bag, placed 50 cm above the patient's plane. After visualization of uterine cavity, a radiotracer (technetium Tc 99m) and patent blue dye were injected subendometrially. During the staging surgery peritoneal free fluid was analyzed to detect patent blue dye, technetium Tc 99m or free cancer cell by cytologic examination.
  
  
  RESULTS
  Technetium Tc 99m and patent blue dye were detected on the peritoneal surface and in the peritoneal fluid in 2 patients. In 1 of these peritoneal cytology was negative for cancer cells. Peritoneal cytology was positive in 2 cases.
  
  
  CONCLUSIONS
  The risk of transtubal fluid leakage during hysteroscopy is absent when performed with intrauterine pressure less than 40 mm Hg. Transtubal fluid leakage is not a synonym of cancer cell dissemination.
authors.affiliation: Department of Gynecologic Oncology, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Solima
authors.forename: Valentina
authors.initials: V
authors.lastname: Brusati
authors.forename: Antonino
authors.initials: A
authors.lastname: Ditto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kusamura
authors.forename: Fabio
authors.initials: F
authors.lastname: Martinelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Hanozet
authors.forename: Maria L
authors.initials: ML
authors.lastname: Carcangiu
authors.forename: Marco
authors.initials: M
authors.lastname: Maccauro
authors.forename: Francesco
authors.initials: F
authors.lastname: Raspagliesi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000473:pathology*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D009366:Neoplasm Seeding; D009367:Neoplasm Staging; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D012965:Sodium Chloride