Experiments confirm the influence of genome long-range correlations on nucleosome positioning.
From the statistical analysis of nucleosome positioning data for chromosome III of S. cerevisiae, we demonstrate that long-range correlations (LRC) in the genomic sequence strongly influence the organization of nucleosomes. We present a physical explanation of how LRC may significantly condition the overall formation and positioning of nucleosomes including the nucleosome-free regions observed at gene promoters. From grand canonical Monte Carlo simulations based upon a simple sequence-dependent nucleosome model, we show that LRC induce a patchy nucleosome occupancy landscape with alternation of "crystal-like" phases of confined regularly spaced nucleosomes and "fluidlike" phases of rather diluted nonpositioned nucleosomes.
Vaillant
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Laboratoire Joliot-Curie and Laboratoire de Physique, CNRS, ENS-Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Audit
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Arneodo
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D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics*; D016681:Genome, Fungal; D008957:Models, Genetic; D009010:Monte Carlo Method; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004271:DNA, Fungal; D009707:Nucleosomes