Silver-catalyzed benzylation and allylation reactions of tertiary and secondary alkyl halides with grignard reagents.
Treatment of alkyl halides, including tertiary alkyl bromides, with benzylic or allylic Grignard reagent in the presence of a catalytic amount of silver nitrate in ether yielded the corresponding cross-coupling products in high yields. The coupling reactions of tertiary alkyl halides provide efficient access to quaternary carbon centers.
Someya
Hidenori
H
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Ohmiya
Hirohisa
H
Yorimitsu
Hideki
H
Oshima
Koichiro
K