A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients.
Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.
Lin
Y-J
YJ
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Wan
L
L
Sheu
J J-C
JJ
Huang
C-M
CM
Lin
C-W
CW
Lan
Y-C
YC
Lai
C-H
CH
Hung
C-H
CH
Tsai
Y
Y
Tsai
C-H
CH
Lin
T-H
TH
Chen
C-P
CP
Tsai
F-J
FJ
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index; D013624:Taiwan
D020382:Interleukin-18