Impaired aortic elastic properties in patients with systemic sarcoidosis.
BACKGROUND
Systemic sarcoidosis (Sar) is a granulomatous disorder involving multiple organs. Widespread vascular involvement and microangiopathy are common in patients with Sar. In addition, subclinical cardiac involvement is increasingly recognized in patients with Sar. However, data on the effect of Sar on the elastic properties of the arteries and myocardial performance are limited. In this study we looked for differences in aortic distensibility (AoD) which is an index of aortic elasticity, and myocardial performance of the ventricles, between patients with Sar and healthy subjects. In addition, we examined potential associations between AoD and clinical, respiratory and echocardiographic findings in patients with Sar.


METHODS
A total of 83 consecutive patients (26 male/57 female, mean age 51.1 +/- 13.3 years) with Sar, without cardiac symptoms, were included. All patients underwent echocardiographic and respiratory evaluation including lung function tests. Additionally, 83 age- and sex-matched healthy subjects served as controls. AoD was determined non-invasively by ultrasonography.


RESULTS
AoD was lower in the Sar compared to the control group (2.29 +/- 0.26 vs. 2.45 +/- 0.20 .10(-) (6) cm2 x dyn(-1), P < 0.01), while left ventricular mass (LVM) was higher in the Sar group (221.3 +/- 50.2 vs. 195.6 +/- 31.3 g, P = 0.007). Furthermore, myocardial performance of both ventricles was impaired in the Sar group. Multivariate linear regression analysis in the total sample population demonstrated a significant and independent inverse relationship between AoD and the presence of Sar (P < 0.001). The same analysis in the Sar patients showed that AoD was associated significantly and independently with the stage of Sar, age, systolic blood pressure, LVM and myocardial performance of both ventricles. No significant relationship was found between AoD and disease duration, pulmonary artery pressure or lung function tests.


CONCLUSIONS
Presence and severity of Sar are associated with reduced aortic distensibility, irrespective of the disease duration, pulmonary artery pressure and lung function. In addition, patients with Sar have increased LVM and impaired myocardial performance.
Moyssakis
I
I
Department of Cardiology, Medical School, National University of Athens, Laiko Hospital, Athens, Greece. moyssak@yahoo.gr
Gialafos
E
E
Tentolouris
N
N
Floudas
C S
CS
Papaioannou
T G
TG
Kostopoulos
Ch
Ch
Latsi
P
P
Vaiopoulos
G
G
Votteas
V
V
Rapti
A
A
D000328:Adult; D000367:Age Factors; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D004548:Elasticity; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging / Q000503:physiopathology; D012737:Sex Factors; D014463:Ultrasonography; D014655:Vascular Resistance; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging / Q000503:physiopathology*