title: Non-invasive fetal sex determination: impact on clinical practice.
abstract: Prenatal fetal sex determination is undertaken in women at high risk of serious genetic disorders affecting a specific sex. Traditionally, this is undertaken by invasive testing, usually chorionic villus sampling, which carries a risk of miscarriage of around 1%. The identification of cell-free fetal DNA in the maternal circulation has allowed the development of 'non-invasive prenatal diagnostic tests', which permit fetal sex determination without risk to the pregnancy.
authors.affiliation: International Blood Group Reference Laboratory, Southmead Road, Bristol, UK.
authors.forename: Kirstin M
authors.initials: KM
authors.lastname: Finning
authors.forename: Lyn S
authors.initials: LS
authors.lastname: Chitty
mesh_terms: D004247:DNA / Q000097:blood*; D005260:Female; D024282:Genes, sry; D030342:Genetic Diseases, Inborn / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012732:Sex Determination Analysis
chemical_list: D004247:DNA