3-trifluoromethanesulfonamido-pyrrolidine: a general organocatalyst for anti-selective mannich reactions.
Mannich-type reactions of a glyoxylate imine with carbonyl compounds catalyzed by 3-trifluoromethanesulfonamidopyrrolidine proceed with high yields and anti-stereoselectivity. The catalyst is easily prepared and the transformation appears to be quite general accommodating aldehydes or ketones.
Pouliquen
Mickael
M
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France.
Blanchet
Jérôme
J
Lasne
Marie-Claire
MC
Rouden
Jacques
J