[Comparative analysis of impact of hereditary and environmental factors on development of some parameters of a human's cardiovascular system on different ontogenesis stages (twin studies)].
Mono- and dizygoted 12-70 year-old twins' permanent ontogenesis on different stages of cardiovascular system had been studied. Zygote was diagnosed with modern methods of research (anthropologic, immune-serologic, mathematic, and dermatogliphic). Altogether 194 couple twins had been examined, from whom 79 couple were monozygotic and 115 - dizygotic. They were divided into three age groups: the first group - of 12-17 year-old, the second - of 30-45 year-old ones, and the third - of 50-70 year-old ones. Modern methods helped to discern importance of genetic and environmental components in whole phenotypic dispersion of cardiac shortening frequency, average arterial pressure, shock and minute volume of heart left ventricle. It was ascertained, already examined hereditary determinacy is conditioned by genetic additive component, and environmental factors are influenced by general family components. With growing of age correlative role of hereditary and environmental factors are either strengthening, or fading. This depends on gender too. Gender dimorphism was also revealed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics*; D002319:Cardiovascular System / Q000254:growth & development*; D002648:Child; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014427:Twins / Q000235:genetics*