title: [Impotence caused by Methotrexate treatment].
abstract: Methotrexate (MTX) is used in the treatment of malignant and non-malignant diseases. This case report describes impotence as a seldom but possible overlooked adverse effect to MTX treatment. A 58 year-old man was treated for erythrodermia with a weekly dose of 7.5 mg MTX. He developed erective impotence nine months after initiation of treatment. Two weeks after discontinuation of MTX the impotence subsided, but when MTX treatment was reintroduced, the impotence returned after two months. Only a few other cases of impotence associated with MTX have been described previously.
authors.affiliation: Klinisk Farmakologisk Enhed, Bispebjerg Hospital, DK-2400 København NV. ip08@bbh.hosp.dk.
authors.forename: Elisabeth I
authors.initials: EI
authors.lastname: Penninga
authors.forename: Helle Kiellberg
authors.initials: HK
authors.lastname: Larsen
authors.forename: Stig Ejdrup
authors.initials: SE
authors.lastname: Andersen
mesh_terms: D003873:Dermatitis, Exfoliative / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate