[Performance profile of FDG-PET and PET/CT for cancer screening based on a Japanese nationwide survey].
A total of 50,558 healthy subjects underwent an FDG-PET (including PET/CT) scan with or without combination of other tests for cancer screening in 46 PET centers during fiscal year of 2005 in Japan. Thorough examination was indicated for 9.8% of the cases due to positive findings suggesting possible cancer. On analyzing 43,996 cases from 38 PET centers, where detailed information was obtained, 500 cases of cancers (1.14%) were found, of which 0.90% was PET positive and 0.24% was PET negative, resulting in the relative sensitivity of PET being 79.0%. Cancers of thyroid, colon/rectum, lung and breast were most frequently found (107, 102, 79, 35 cases, respectively) with high PET sensitivity (88%, 90%, 80%, 92%). PET showed an overall positive predictive value of 29.0%. PET/CT had better detection rate, sensitivity, and positive predictive value than dedicated PET (p<0.01).
Minamimoto
Ryogo
R
Department of Radiology, Graduate School of Medicine, Yokohama City University.
Senda
Michio
M
Uno
Kimiichi
K
Jinnouchi
Seishi
S
Iinuma
Takeshi
T
Ito
Kengo
K
Okuyama
Chio
C
Oguchi
Kazuhiro
K
Kawamoto
Masami
M
Suzuki
Yutaka
Y
Tsukamoto
Eriko
E
Terauchi
Takashi
T
Nakashima
Rumi
R
Nishio
Masami
M
Nishizawa
Sadahiko
S
Fukuda
Hiroshi
H
Yoshida
Tsuyoshi
T
Inoue
Tomio
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18