[Photo-degradation products of 1-[1-(6-methoxy-2-naphthyl)ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide].
To study the photo-degradation products of 1-[1-(6-methoxy-2-naphthyl) ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (code designation: P91024). The chemical structures of the major photo-degradation products of P91024 were identified by HPLC-MS and spectroscopic methods, and their reference substances were also synthesized for confirmation. The three major photo-degradation products were identified to be N-(4-nitrobenzyl)-6,7-dimethoxyl-3, 4-dihydroisoquinoline bromide, 1-[1-(6-methoxyl-2-naphthyl) ethyl]-6, 7-dimethoxyl-1, 2, 3, 4-tetrahydroisoquinoline and 2-isopropyl-6-methoxyl-naphthalene, respectively.
Jiang
Hong
H
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nangjing 210009, China.
Song
Min
M
Hang
Tai-jun
TJ
Zhang
Zheng-xing
ZX
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005343:Fibrinolytic Agents / Q000737:chemistry*; D015394:Molecular Structure; D010782:Photolysis; D011786:Quality Control; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
D005343:Fibrinolytic Agents; C542583:P91024; D044005:Tetrahydroisoquinolines