title: Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas.
abstract: Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Ullõi út 26, Budapest 1085, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dezso
authors.forename: Judit
authors.initials: J
authors.lastname: Halász
authors.forename: Hanne Cathrine
authors.initials: HC
authors.lastname: Bisgaard
authors.forename: Sándor
authors.initials: S
authors.lastname: Paku
authors.forename: Eszter
authors.initials: E
authors.lastname: Turányi
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Schaff
authors.forename: Peter
authors.initials: P
authors.lastname: Nagy
mesh_terms: D000293:Adolescent; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002135:Calcium-Binding Proteins; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D053539:Keratin-19 / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D053539:Keratin-19; D008565:Membrane Proteins; D000509:alpha-Fetoproteins