title: Adiponectin and cardiovascular inflammatory responses.
abstract: Obesity is recognized as a cause of many metabolic and cardiovascular disorders through its ability to promote chronic systemic inflammation. Recent studies have found that adipose tissues secrete numerous cytokines that are referred to as adipokines. Although most adipokines induce inflammation, adiponectin inhibits inflammatory reactions and protects against metabolic and cardiovascular diseases. This review focuses on the anti-inflammatory properties of adiponectin in various experimental systems, especially with respect to cardiovascular diseases.
authors.affiliation: Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Takemura
authors.forename: Kenneth
authors.initials: K
authors.lastname: Walsh
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
mesh_terms: D052242:Adiponectin / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D018450:Disease Progression; D006321:Heart / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D054419:Receptors, Adiponectin / Q000502:physiology
chemical_list: D052242:Adiponectin; D054419:Receptors, Adiponectin