title: The chick chorioallantoic membrane as an in vivo angiogenesis model.
abstract: The chick chorioallantoic membrane (CAM) assay for angiogenic activity is a model originally developed to study the angiogenic activity of tumor samples. It is an in vivo assay that can be readily performed in any laboratory setting. The effects of a test compound on angiogenesis are tested by exposing day 10 embryos to the compound and following the patterns of blood vessel development, scoring the appearance of the CAM at day 12 or 13.
authors.affiliation: National Institutes of Health Bethesda, Maryland, USA.
authors.forename: M Lourdes
authors.initials: ML
authors.lastname: Ponce
authors.forename: Hynda K
authors.initials: HK
authors.lastname: Kleinmann
mesh_terms: D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply* / Q000166:cytology; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D016222:Fibroblast Growth Factor 2