R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians.
The human rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of rho GTPases and is supposed to influence insulin signalling. We investigated the effects of the previously reported R1467H variant in individual's susceptibility to type 2 diabetes (T2D) and impaired glucose tolerance (IGT) as well as related traits in a German Caucasian cohort. Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT.
Böttcher
Yvonne
Y
Medical Department III, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103, Leipzig, Germany. yvonne.boettcher@medizin.uni-leipzig.de.
Schleinitz
Dorit
D
Interdisciplinary Center for Clinical Research IZKF, University of Leipzig, Inselstrasse 22, 04103, Leipzig, Germany.
Tönjes
Anke
A
Medical Department III, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103, Leipzig, Germany.|Coordination Center for Clinical Trials, University of Leipzig, Leipzig, Germany.
Blüher
Matthias
M
Medical Department III, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103, Leipzig, Germany.
Stumvoll
Michael
M
Medical Department III, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103, Leipzig, Germany.
Kovacs
Peter
P
Interdisciplinary Center for Clinical Research IZKF, University of Leipzig, Inselstrasse 22, 04103, Leipzig, Germany. peter.kovacs@medizin.uni-leipzig.de.
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005858:Germany; D005951:Glucose Tolerance Test; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D020125:Mutation, Missense / Q000235:genetics*; D064067:Rho Guanine Nucleotide Exchange Factors; D044465:White People / Q000235:genetics*
C577234:ARHGEF11 protein, human; D020662:Guanine Nucleotide Exchange Factors; D064067:Rho Guanine Nucleotide Exchange Factors