title: Early-onset obsessive-compulsive disorder and personality disorders in adulthood.
abstract: Obsessive-compulsive disorder (OCD) often emerges in childhood or adolescence. The aim of the present study was to evaluate whether adult patients with prepuberal onset differ from subjects with later onset in terms of personality disorder comorbidity. The Structured Clinical Interview for DSM-IV Axis II Disorders was used to assess 148 patients with a principal diagnosis of OCD according to the Structured Clinical Interview for DSM-IV Axis I Disorders. The following two subgroups of subjects were selected according to the age at onset of symptomatology: patients with an early-onset (< or =10 years), and patients with a later onset (> or =17 years). Of the 148 patients screened for the present study, 33 (22.3%) had an early onset and 1369 (46.6%) had a later onset. With regard to personality disorders, early-onset patients showed more OC personality disorders (OCPD) than later onset patients. Our finding suggests that OCD in childhood increases the risk for developing OCPD in adulthood, or that early-onset OCD and OCPD share a common pathogenesis.
authors.affiliation: Department of Neurosciences, Mood and Anxiety Disorders Unit, University of Turin, Via Cherasco 11-10126 Torino, Italy. giuseppemaina@hotmail.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maina
authors.forename: Umberto
authors.initials: U
authors.lastname: Albert
authors.forename: Virginio
authors.initials: V
authors.lastname: Salvi
authors.forename: Enrico
authors.initials: E
authors.lastname: Pessina
authors.forename: Filippo
authors.initials: F
authors.lastname: Bogetto
mesh_terms: D000328:Adult; D017668:Age of Onset; D002648:Child; D003627:Data Interpretation, Statistical; D003710:Demography; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires