Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix.
BACKGROUND
Prognostic significance of squamous cell carcinoma antigen (SCC-Ag), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA) and neopterin in cervical cancer patients was compared.


METHODS
Pretreatment concentrations were determined in 138 women.


RESULTS
Median age was 52 years, 85% squamous cell carcinomas, 15% adeno- or adenosquamous carcinomas were seen. In 36% Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, 24% stage II, 32% stage III and 8% stage IV was diagnosed. TPA was elevated in 22%, SCC in 68%, CEA in 42% and neopterin in 29%. These patients showed significantly worse overall survival in univariate analysis (p<0.001). TPA remained as independent prognostic factor in multivariate analysis.


CONCLUSIONS
Elevation of TPA was associated with worse overall survival.
Volgger
Birgit
B
Medical University of Innsbruck, Department of Obstetrics and Gynaecology, Anichstrasse 35, 6020 Innsbruck, Austria. birgit.volgger@i-med.ac.at
Aspisirengil
Coskun
C
Genser-Krimbacher
Elisabeth
E
Ciresa-Koenig
Alexandra
A
Daxenbichler
Günter
G
Fuchs
Dietmar
D
Windbichler
Gudrun
G
Marth
Christian
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D019798:Neopterin / Q000032:analysis*; D011379:Prognosis; D015843:Serpins / Q000032:analysis*; D016019:Survival Analysis; D019396:Tissue Polypeptide Antigen / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000401:mortality
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; D019396:Tissue Polypeptide Antigen; C051072:squamous cell carcinoma-related antigen; D019798:Neopterin