title: [Pharmacokinetics of pueraria for intranasal on spray in rabbits].
abstract: OBJECTIVE
  To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits.
  
  
  METHODS
  The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters.
  
  
  RESULTS
  The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h.
  
  
  CONCLUSIONS
  The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Tao
authors.forename: Lian-ying
authors.initials: LY
authors.lastname: Xu
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007529:Isoflavones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D011817:Rabbits; D013997:Time Factors
chemical_list: D000336:Aerosols; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C033607:puerarin