title: Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives.
abstract: Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10(-3) M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.
authors.affiliation: Department of Pharmaceutical Chemistry Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.
authors.forename: Ilgar
authors.initials: I
authors.lastname: Kerimov
authors.forename: Gülgün
authors.initials: G
authors.lastname: Ayhan-Kilcigil
authors.forename: Benay
authors.initials: B
authors.lastname: Can-Eke
authors.forename: Nurten
authors.initials: N
authors.lastname: Altanlar
authors.forename: Mümtaz
authors.initials: M
authors.lastname: Iscan
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D001562:Benzimidazoles; D002110:Caffeine; C031000:benzimidazole