[Progress of the study on iron disorder diseases].
The important function of iron as a necessary nutrition element in mammals is more and more recognized by people. The normal physiological level of iron is ensured by the rigid regulation mechanism of iron metabolism in animals. Various clinical diseases are induced by iron disorder, like iron deficiency and iron overloading in the body. The current study showed that Hepcidin may be a key factor to control intestinal iron absorbing and regulates iron homeostasis, and may be an important regulating hormone of iron metabolism. It was summarized in this paper that the physiological functions, iron deficiency diseases, for instance iron deficiency anemia and neural diseases of children, and iron overload diseases, such as liver damage, cardiovascular diseases, Parkinson's disease, and cancers etc. And it was expected how to develop the therapy of iron disorder diseases in gene level use modern techniques.
Wang
Li
L
Institute of Neurobiology and Neuropharmacology, Hebei Normal University, Shijiazhuang 050016, China.
Duan
Xiang-Lin
XL
Wang
Ying-Ze
YZ
Chang
Yan-Zhong
YZ
Qian
Zhong-Ming
ZM
D018798:Anemia, Iron-Deficiency / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology*; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron