Fighting fat with muscle: bulking up to slim down.
Akt1 is a well-characterized mediator of muscle hypertrophy. In this issue of Cell Metabolism, Izumiya et al. (2008) reveal a striking link between Akt1 signaling, fast muscle fiber size, and whole-body metabolism. These results provide new insights into the ability of muscle to combat diet-induced obesity and metabolic dysfunction.
Harrison
Brooke C
BC
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA.
Leinwand
Leslie A
LA
D000273:Adipose Tissue; D000818:Animals; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*
D051057:Proto-Oncogene Proteins c-akt