[Genomic approaches to bone and joint diseases. An important role of cross-talk between BMP and Wnt on bone formation].
BMPs bound to specific receptors expressed on cell membrane of target cells, then activate Smad-dependent intracellular signaling. Wnt signaling through LRP5 receptor has been genetically shown to be involved in bone formation in humans. Recently, it was shown that Smad1 degradation requires phosphorylation by GSK3beta, which is suppressed by Wnt signaling. These findings suggest that a cross-talk between BMP and Wnt through Smad1 plays an important role on bone formation.
Katagiri
Takenobu
T
Saitama Medical University, Research Center for Genomic Medicine, Division of Pathophysiology.
Fukuda
Toru
T
Nojima
Junya
J
Kanomata
Kazuhiro
K
Nakamura
Atsushi
A
D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*
D019485:Bone Morphogenetic Proteins; D051153:Wnt Proteins