title: Changes in quality of life in people with Parkinson's disease left untreated at diagnosis.
abstract: BACKGROUND
  The issue of whether to adopt a "wait and watch" strategy or to initiate drug therapy soon after diagnosis in Parkinson's disease (PD) has been the subject of some debate. A recent observational study supported early treatment by demonstrating deterioration in self-reported health status in those left untreated, but not those who received therapy. We aimed to replicate this observation.
  
  
  METHODS
  People with PD from a prospective incidence study underwent follow-up with yearly clinical assessment of parkinsonian impairment (Unified Parkinson's Disease Rating Scale (UPDRS)) and self-reported health status (Parkinson's Disease Questionnaire (PDQ-39)). Two year outcomes were compared with those who started treatment within 1 year of diagnosis and those left untreated.
  
  
  RESULTS
  42 patients with PD were followed-up for 2 years, of whom 26 started treatment during the first year and 16 remained untreated. Those receiving treatment had significantly higher UPDRS and PDQ-39 scores at baseline. There was no significant deterioration in PDQ-39 score in either group (median change untreated 0.8 vs treated 4.0; p = 0.47), despite a significant difference in the change in motor UPDRS scores (untreated 6.0 vs treated -6.0; p = 0.03).
  
  
  CONCLUSIONS
  Given the lack of significant deterioration in the PDQ-39 in untreated patients, we believe a "wait and watch" strategy for the treatment of newly diagnosed PD remains a credible approach unless randomised trials prove otherwise.
authors.affiliation: Crosshouse Hospital, Kilmarnock, UK.
authors.forename: P
authors.initials: P
authors.lastname: Asimakopoulos
authors.forename: R
authors.initials: R
authors.lastname: Caslake
authors.forename: C E
authors.initials: CE
authors.lastname: Harris
authors.forename: J C
authors.initials: JC
authors.lastname: Gordon
authors.forename: K S M
authors.initials: KS
authors.lastname: Taylor
authors.forename: C
authors.initials: C
authors.lastname: Counsell
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D019370:Observation; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*
chemical_list: D000978:Antiparkinson Agents