[Matrine and anti-tumor drugs in inhibiting the growth of human lung cancer cell line].
OBJECTIVE
To study the activities of matrine and anti-tumor drugs on SPCA/I human lung adenocarcinoma cell line.


METHODS
Suppression effects of different concentrations of matrine and matrine combined with anti-tumor drugs on lung cancer cells were measured by methyl thiazolyl tetrazolium (MTT) colorimetric assay.


RESULTS
Different concentrations of matrine could inhibit the growth of SPCA/I human lung adenocarcinoma cells and there was a positive correlation between the inhibition rate and the drug concentration. Different concentrations of matrine combined with anti-tumor drugs had higher growth inhibition rate than anti-tumor drugs alone.


CONCLUSIONS
Matrine has direct growth suppression effect on SPCA/I human lung adenocarcinoma cells and matrine combined with anti-tumor drugs shows a significant synergistic effect on tumor cells.
Zhu
Mu-Yun
MY
Department of Respiratory Diseases, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China. yzszmy@163.com
Jiang
Zheng-Hua
ZH
Lu
Yuan-Wen
YW
Guo
Yuan
Y
Gan
Jun-Ji
JJ
D000230:Adenocarcinoma / Q000473:pathology*; D000470:Alkaloids / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D011807:Quinolizines / Q000494:pharmacology*; D000093842:Matrines
D000470:Alkaloids; D000970:Antineoplastic Agents; D011807:Quinolizines; D000093842:Matrines