Role of ATP-sensitive potassium channels in the piracetam induced blockade of opioid effects.
The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded in KCl-precontracted isolated rat aortic ring preparation. Piracetam attenuated buprenorphine-induced antinociception in rats. Piracetam significantly reduced the morphine and minoxidil induced relaxation in KCl precontracted isolated rat aortic ring preparation suggesting that piracetam interferes with opioid receptor and ATP-sensitive potassium channel (KATP) opener mediated responses in vitro. Thus, it may be suggested that piracetam attenuates opioid effects by an opioid receptor-KATP channel linked mechanism.
Rehni
Ashish K
AK
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, India. ashishkrehni@gmail.com
Singh
Nirmal
N
Jindal
Seema
S
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D054086:KATP Channels / Q000187:drug effects*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018847:Opioid Peptides / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects
D000701:Analgesics, Opioid; D054086:KATP Channels; D018696:Neuroprotective Agents; D018847:Opioid Peptides; D011957:Receptors, Opioid; D010889:Piracetam