Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose.
Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine), bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is a time-dependent reversible process. The equilibrium is attained within 2.5-8.0 h and depends on the chemical nature of local anesthetic.
Galenko-Yaroshevskii
A P
AP
Krasnodar Affiliated Department of Southern Bureau of Russian Academy of Medical Sciences, Moscow, Russia.
Varlashkina
I A
IA
Takhchidi
Kh P
KhP
Malyugin
B E
BE
Dukhanin
A S
AS
D000779:Anesthetics, Local / Q000737:chemistry*; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008968:Molecular Conformation; D012996:Solutions; D014867:Water
D000779:Anesthetics, Local; D012996:Solutions; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose