title: In vitro antifungal activity of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole derivatives.
abstract: OBJECTIVE
  The aim of the study was the determination of antifungal activity of new of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole (AOAT) derivatives against Candida albicans, non-Candida albicans.
  
  
  METHODS
  The determination of antifungal activity AOATs against 20 Candida albicans, 18 non-Candida albicans was performed. Isolates were from different ontocenoses of patients were used for tests. AOATs were synthesized at Department of Chemistry University of Agriculture in Lublin.
  
  
  RESULTS
  The mean MIC of AOATs against Candida albicans strains was 141.625 (37.5-200) mg/L on Sabouraud's medium (SB). The mean MIC of AOATs against non-Candida albicans strains was 153.3 (50-200) mg/L.
  
  
  CONCLUSIONS
  It seems that AOATs exert potent antifungal activity against the yeast-like fungi strains in vitro.
authors.affiliation: Department of General Nursing, Medical Academy in Białystok, Poland. cecylia.lukaszuk@wp.pl
authors.forename: C
authors.initials: C
authors.lastname: Lukaszuk
authors.forename: E
authors.initials: E
authors.lastname: Krajewska-Kułak
authors.forename: A
authors.initials: A
authors.lastname: Niewiadomy
authors.forename: J
authors.initials: J
authors.lastname: Stachowicz
authors.forename: U
authors.initials: U
authors.lastname: Głaszcz
authors.forename: E
authors.initials: E
authors.lastname: Oksiejczuk
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D013830:Thiadiazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D013830:Thiadiazoles