Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1.
The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.
Sajikumar
Sreedharan
S
Department for Neurophysiology, Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany.
Navakkode
Sheeja
S
Frey
Julietta U
JU
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004558:Electric Stimulation / Q000379:methods*; D004640:Emetine / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000502:physiology; D050641:Receptors, Dopamine D5 / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013569:Synapses / Q000502:physiology; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D001552:Benzazepines; D018492:Dopamine Antagonists; D011500:Protein Synthesis Inhibitors; D017447:Receptors, Dopamine D1; D016194:Receptors, N-Methyl-D-Aspartate; D050641:Receptors, Dopamine D5; D000841:Anisomycin; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine; D004640:Emetine