[The specific features of penetration of the antioxidant histochrome across the blood-ocular barrier: an experimental study].
Analysis of intraocular fluid and the vitreous body in 7 rabbits (14 eyes) by high performance liquid chromatography reveals histochrom metabolic products and, possibly, histrochrom itself during intravenous and subconjunctival injections and retrobulbar administration of histochrom through the irrigation system on models of experimental rabbit hyphema and hemophthalmia, which suggests that histochrom is able to penetrate across the blood-ocular barrier.
Guseva
M R
MR
Beslaneeva
M B
MB
Mishchenko
N P
NP
Khuraĭ
A R
AR
D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry / Q000378:metabolism*; D018916:Blood-Aqueous Barrier / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D006988:Hyphema / Q000188:drug therapy / Q000378:metabolism; D009285:Naphthoquinones / Q000493:pharmacokinetics*; D011817:Rabbits; D014822:Vitreous Body / Q000737:chemistry / Q000378:metabolism*
D009285:Naphthoquinones; C103614:histochrome