title: Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats.
abstract: Comparative morphometrical study of the renal glomerular system was carried out in hypertensive NISAG rats treated with hypotensive drugs during the prepubertal period. Blockade of the renin-angiotensin system with enalapril or losartan during the critical period of ontogeny (the 2nd month of life) produced a long-term hypotensive and renoprotective effect. Treatment with alpha-adrenoblocker terazosin during this period of ontogeny produced a less pronounced hypotensive effect, though with renoprotection. Corinfar (Ca2+ channel blocker) was least effective.
authors.affiliation: Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. e.e.filjushina@iph.ma.nsc.ru
authors.forename: E E
authors.initials: EE
authors.lastname: Filyushina
authors.forename: M D
authors.initials: MD
authors.lastname: Shmerling
authors.forename: V A
authors.initials: VA
authors.lastname: Lazarev
authors.forename: I I
authors.initials: II
authors.lastname: Buzuyeva
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
authors.forename: G S
authors.initials: GS
authors.lastname: Yakobson
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004656:Enalapril / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use; D011224:Prazosin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D004656:Enalapril; C041226:Terazosin; D009543:Nifedipine; D019808:Losartan; D011224:Prazosin