title: Skeletal muscle relaxants.
abstract: Health care providers prescribe skeletal muscle relaxants for a variety of indications. However, the comparative efficacy of these drugs is not well known. Skeletal muscle relaxants consist of both antispasticity and antispasmodic agents, a distinction prescribers often overlook. The antispasticity agents-baclofen, tizanidine, dantrolene, and diazepam-aid in improving muscle hypertonicity and involuntary jerks. Antispasmodic agents, such as cyclobenzaprine, are primarily used to treat musculoskeletal conditions. Much of the evidence from clinical trials regarding skeletal muscle relaxants is limited because of poor methodologic design, insensitive assessment methods, and small numbers of patients. Although trial results seem to support the use of these agents for their respective indications, efficacy data from comparator trials did not particularly favor one skeletal muscle relaxant over another. Therefore, the choice of a skeletal muscle relaxant should be based on its adverse-effect profile, tolerability, and cost.
authors.affiliation: Clinical Pharmacy Practice Department, St. John's University College of Pharmacy and Allied Health Professions, Queens, New York, NY 11439, USA. sees@stjohns.edu
authors.forename: Sharon
authors.initials: S
authors.lastname: See
authors.forename: Regina
authors.initials: R
authors.lastname: Ginzburg
mesh_terms: D004347:Drug Interactions; D006801:Humans; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D009140:Musculoskeletal Diseases / Q000188:drug therapy; D009422:Nervous System Diseases / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central