title: Translational research in aphasia: from neuroscience to neurorehabilitation.
abstract: OBJECTIVE
  In this article, the authors encapsulate discussions of the Language Work Group that took place as part of the Workshop in Plasticity/NeuroRehabilitation Research at the University of Florida in April 2005.
  
  
  METHODS
  In this narrative review, they define neuroplasticity and review studies that demonstrate neural changes associated with aphasia recovery and treatment. The authors then summarize basic science evidence from animals, human cognition, and computational neuroscience that is relevant to aphasia treatment research. They then turn to the aphasia treatment literature in which evidence exists to support several of the neuroscience principles.
  
  
  CONCLUSIONS
  Despite the extant aphasia treatment literature, many questions remain regarding how neuroscience principles can be manipulated to maximize aphasia recovery and treatment. They propose a framework, incorporating some of these principles, that may serve as a potential roadmap for future investigations of aphasia treatment and recovery. In addition to translational investigations from basic to clinical science, the authors propose several areas in which translation can occur from clinical to basic science to contribute to the fundamental knowledge base of neurorehabilitation. This article is intended to reinvigorate interest in delineating the factors influencing successful recovery from aphasia through basic, translational, and clinical research.
authors.affiliation: 110 Child Study Center, Old Dominion University, Norfolk, VA 23529-0136, USA. sraymer@odu.edu
authors.forename: Anastasia M
authors.initials: AM
authors.lastname: Raymer
authors.forename: Pelagie
authors.initials: P
authors.lastname: Beeson
authors.forename: Audrey
authors.initials: A
authors.lastname: Holland
authors.forename: Diane
authors.initials: D
authors.lastname: Kendall
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Maher
authors.forename: Nadine
authors.initials: N
authors.lastname: Martin
authors.forename: Laura
authors.initials: L
authors.lastname: Murray
authors.forename: Miranda
authors.initials: M
authors.lastname: Rose
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Thompson
authors.forename: Lyn
authors.initials: L
authors.lastname: Turkstra
authors.forename: Lori
authors.initials: L
authors.lastname: Altmann
authors.forename: Mary
authors.initials: M
authors.lastname: Boyle
authors.forename: Tim
authors.initials: T
authors.lastname: Conway
authors.forename: William
authors.initials: W
authors.lastname: Hula
authors.forename: Kevin
authors.initials: K
authors.lastname: Kearns
authors.forename: Brenda
authors.initials: B
authors.lastname: Rapp
authors.forename: Nina
authors.initials: N
authors.lastname: Simmons-Mackie
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Gonzalez Rothi
mesh_terms: D000818:Animals; D001037:Aphasia / Q000503:physiopathology / Q000534:rehabilitation* / Q000628:therapy*; D006801:Humans; D009462:Neurology / Q000639:trends*; D009473:Neuronal Plasticity