title: Women with low-energy fracture should be investigated for osteoporosis.
abstract: BACKGROUND
  Treatment of osteoporosis is becoming more effective, but methods to identify patients who are most suitable for investigation and treatment are still being debated. Should any type of fracture have higher priority for investigation of osteoporosis than any other? Is the number of previous fractures useful information?
  
  
  METHODS
  We investigated 303 consecutive women patients between 55 and 75 years of age who had a newly diagnosed low-energy fracture. They answered a questionnaire on previous fractures which also dealt with risk factors. Bone mineral density (BMD) was measured at the hip, lumbar spine, and forearm.
  
  
  RESULTS
  The distribution of fracture location was: distal forearm 56%, proximal humerus 12%, vertebra 18%, and hip 13%, all with similar age. Half of the subjects had had at least one previous fracture before the index fracture, 19% had had two previous fractures, and 6% had had three or more previous fractures. Patients with vertebral or hip fracture had lower BMD and had had more previous fractures than patients with forearm or humerus fractures. There was an inverse correlation between number of fractures and BMD. Osteoporosis was present in one-third of patients with forearm fracture, in one-half of those with hip or humerus fracture, and in two-thirds of those with vertebral fracture.
  
  
  CONCLUSIONS
  Vertebral fractures were the strongest marker of low BMD and forearm fractures the weakest. The number of previous fractures is helpful information for finding the most osteoporotic patient in terms of severity. Investigation of osteoporosis therefore seems warranted in every woman between the ages of 55 and 75 with a recent low-energy fracture, with highest priority being given to those with vertebral, hip, or multiple fractures.
authors.affiliation: Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As, Norway. owe.lofman@umb.no
authors.forename: Owe
authors.initials: O
authors.lastname: Löfman
authors.forename: Inger
authors.initials: I
authors.lastname: Hallberg
authors.forename: Kenneth
authors.initials: K
authors.lastname: Berglund
authors.forename: Ola
authors.initials: O
authors.lastname: Wahlström
authors.forename: Lisa
authors.initials: L
authors.lastname: Kartous
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Rosenqvist
authors.forename: Lasse
authors.initials: L
authors.lastname: Larsson
authors.forename: Göran
authors.initials: G
authors.lastname: Toss
mesh_terms: D000368:Aged; D015519:Bone Density; D005260:Female; D050723:Fractures, Bone / Q000175:diagnosis* / Q000209:etiology; D005598:Fractures, Spontaneous / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000175:diagnosis*; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires