Enzyme inhibition activities of the extracts from rhizomes of Gloriosa superba Linn (Colchicaceae).
An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was screened for enzyme inhibition activities. The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease. An outstanding inhibition on lipoxygenase was observed. The highest enzyme inhibition potency was expressed by the chloroform fraction (90%) among the tested fractions on lipoxygenase. Overall 67-90% inhibition was found for lipoxygenase, 46-69% for acetylcholinesterase and 10-33% for butyrylcholinesterase, while urease was not inhibited.
Khan
Haroon
H
Department of Pharmacy, University of Peshawar, N. W.F.P, Pakistan. harronkhan3@yahoo.com
Khan
Murad Ali
MA
Hussan
Iqbal
I
D018680:Cholinergic Antagonists / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D019668:Liliaceae / Q000737:chemistry*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*
D018680:Cholinergic Antagonists; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase