The olfactory vector hypothesis of neurodegenerative disease: is it viable?
Environmental agents, including viruses, prions, and toxins, have been implicated in the cause of a number of neurodegenerative diseases, most notably Alzheimer's and Parkinson's diseases. The presence of smell loss and the pathological involvement of the olfactory pathways in the formative stages of Alzheimer's and Parkinson's diseases, together with evidence that xenobiotics, some epidemiologically linked to these diseases, can readily enter the brain via the olfactory mucosa, have led to the hypothesis that Alzheimer's and Parkinson's diseases may be caused or catalyzed by agents that enter the brain via this route. Evidence for and against this concept, the "olfactory vector hypothesis," is addressed in this review.
Doty
Richard L
RL
Smell and Taste Center and Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. doty@mail.med.upenn.edu
D000544:Alzheimer Disease / Q000139:chemically induced / Q000503:physiopathology / Q000821:virology; D000818:Animals; D001370:Axonal Transport; D018450:Disease Progression; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000821:virology*; D000857:Olfaction Disorders / Q000139:chemically induced* / Q000503:physiopathology / Q000821:virology*; D009831:Olfactory Mucosa / Q000187:drug effects / Q000503:physiopathology / Q000821:virology; D010300:Parkinson Disease / Q000503:physiopathology / Q000821:virology; D014777:Virus Diseases / Q000503:physiopathology
D015386:Hazardous Substances