title: [Pharmacokinetics of paroxetine tablet in healthy Chinese volunteers].
abstract: OBJECTIVE
  To study the pharmacokinetics of paroxetine tablet in Chinese healthy volunteers.
  
  
  METHODS
  Twenty healthy subjects received a single oral dose of 40 mg paroxetine tablet. The plasma concentrations of paroxetine were determined using high-performance liquid chromatography (HPLC) and the measurements were analyzed with 3P97 program.
  
  
  RESULTS
  The plasma concentration curve of paroxetine following a single oral dose administration conformed to the two-compartment open model. The main pharmacokinetics parameters of paroxetine were: C(max)64.74-/+18.43 ng/ml, T(max)5.64-/+1.84 h, t(1/2) 20.03-/+5.33 h, AUC(0-120) 976.47-/+309.49 ng.h/ml, and AUC(0-inf) 1086.75-/+376.54 ng.h/ml.
  
  
  CONCLUSIONS
  The pharmacokinetics of paroxetine in human body conforms to the two-compartment open model.
authors.affiliation: Department of Pharmacy, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. dropwatercat@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Wei-zhong
authors.initials: WZ
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Wen-xian
authors.initials: WX
authors.lastname: Liu
authors.forename: Hua-cheng
authors.initials: HC
authors.lastname: Wang
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D017374:Paroxetine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets; D055815:Young Adult
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D013607:Tablets