Synergistic effect of two solvents, tert-alcohol and ionic liquid, in one molecule in nucleophilic fluorination.
We have demonstrated the synergistic effect in nucleophilic fluorination when we combined two solvents--ionic liquid (IL) and tert-alcohol--into one molecule. Consequently, these functionalized ILs not only increase the nucleophilic reactivities of the fluoride anion but also remarkably reduce the olefin byproduct. Although the mechanism of this synergistic effect remains to be elucidated, we have illustrated the possibility of solvent engineering for a specific reaction.
Shinde
Sandip S
SS
Department of Chemistry, Inha University, 253 Yonghyundong Namgu, Inchon 402-751, Korea.
Lee
Byoung Se
BS
Chi
Dae Yoon
DY