Phylogenetic analysis of hemagglutinin, neuraminidase, and nucleoprotein genes of H9N2 avian influenza viruses isolated in Israel during the 2000-2005 epizootic.
The first two isolates of H9N2 influenza virus in Israel were collected from turkey and chicken hosts in May 2000. The actual epizootic of the H9N2 virus started in December 2001, after a 1.5-year period of silence, and still continues. A total of more than 500 isolations from turkeys and chickens were registered during the outbreaks. The present study has revealed some genetic peculiarities among the local isolates, namely: all the isolates belong to the same G1-like phylogenetic lineage, within which they form a single group, which, in turn, is divided into three subgroups in the cases of the HA and NP genes, and two subgroups in the case of the NA gene. The results present a basis for suggesting the existence of two parallel evolutionary trends originating from the same local "prototype" isolate.
Perk
Shimon
S
Division of Avian and Aquatic Diseases, Kimron Veterinary Institute, Beit Dagan, Israel.
Golender
Natalia
N
Banet-Noach
Caroline
C
Shihmanter
Ester
E
Pokamunsky
Shimon
S
Pirak
Michael
M
Tendler
Yevgenii
Y
Lipkind
Michael
M
Panshin
Alexander
A
D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D002645:Chickens / Q000235:genetics; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000145:classification* / Q000235:genetics; D053127:Influenza A Virus, H9N2 Subtype / Q000235:genetics* / Q000302:isolation & purification; D005585:Influenza in Birds / Q000453:epidemiology* / Q000821:virology; D007557:Israel / Q000453:epidemiology; D009439:Neuraminidase / Q000145:classification* / Q000235:genetics; D019590:Nucleocapsid Proteins; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000145:classification* / Q000235:genetics; D014422:Turkeys / Q000821:virology; D014758:Viral Core Proteins / Q000145:classification* / Q000235:genetics
D019267:Hemagglutinin Glycoproteins, Influenza Virus; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D009439:Neuraminidase