title: Comparative pharmacokinetics of tylosin or florfenicol after a single intramuscular administration at two different doses of tylosin-florfenicol combination in pigs.
abstract: Clinical pharmacokinetic profiles were investigated following intramuscular (i.m.) administration to pigs with a commercial tylosin-florfenicol combination product at a dose of 2.5 mg/kg tylosin and 5 mg/kg florfenicol or 10 mg/kg tylosin and 20 mg/kg florfenicol. The quantitation limit (QL) of florfenicol was 0.1 microg/ml, the inter-day and intra-day precision (CV%) were both beow 10%. The quantitation limit (QL) of tylosin was 0.05 microg/mL. The pharmacokinetic characteristics after i.m. doses were fitted by a one compartment open model. A fourfold decrease in the normal dose of each drug (20 mg/kg to 5 mg/kg for florfenicol, and 10 mg/kg to 2.5 mg/kg for tylosin) resulted in a corresponding two fold decrease in each drug of the maximum plasma concentration (C(max)) and the area under curve (AUC) values.
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Mi-Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Elias
authors.initials: E
authors.lastname: Gebru
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Chang
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Hwang
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kang
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D006207:Half-Life; D007273:Injections, Intramuscular; D013552:Swine / Q000378:metabolism*; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D015645:Tylosin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C035534:florfenicol; D013839:Thiamphenicol; D015645:Tylosin