Transkarbams with terminal branching as transdermal permeation enhancers.
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
Klimentová
Jana
J
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 50005, Czech Republic.
Kosák
Petr
P
Vávrová
Katerina
K
Holas
Tomás
T
Novotný
Jakub
J
Hrabálek
Alexandr
A
D000279:Administration, Cutaneous; D000818:Animals; D002219:Carbamates / Q000737:chemistry* / Q000493:pharmacokinetics*; D010539:Permeability; D012867:Skin; D012869:Skin Absorption / Q000187:drug effects*; D013552:Swine; D013806:Theophylline / Q000008:administration & dosage
D002219:Carbamates; D013806:Theophylline