title: Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
abstract: A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Gooden
authors.forename: Dawn M Z
authors.initials: DM
authors.lastname: Schmidt
authors.forename: Julie A
authors.initials: JA
authors.lastname: Pollock
authors.forename: Ami M
authors.initials: AM
authors.lastname: Kabadi
authors.forename: Dewey G
authors.initials: DG
authors.lastname: McCafferty
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D056466:Histone Demethylases; D006657:Histones / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000737:chemistry / Q000187:drug effects*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014191:Tranylcypromine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D006657:Histones; D014191:Tranylcypromine; D056466:Histone Demethylases; D008995:Monoamine Oxidase; C495195:KDM1A protein, human; D010089:Oxidoreductases, N-Demethylating