title: Decreased coronary flow reserve in haemodialysis patients.
abstract: BACKGROUND
  Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work.
  
  
  METHODS
  Forty-one patients who had already undergone coronary angiography were studied. They consisted of 21 haemodialysis patients with no significant left anterior descending coronary artery (LAD) stenosis and 20 non-renal failure patients without LAD stenosis. We performed transthoracic Doppler recording of diastolic coronary flow velocity in the LAD at baseline and after maximal vasodilatation by adenosine triphosphate (ATP) infusion. CFR was defined as the ratio of hyperaemic to basal averaged peak flow velocity.
  
  
  RESULTS
  Although the peak coronary velocities during hyperaemia were similar between the two groups, CFR was smaller in haemodialysis (HD) patients than in control subjects (1.96 +/- 04 versus 2.3 +/- 0.5, P = 0.001) due to the higher baseline peak coronary velocities in the former.
  
  
  CONCLUSIONS
  The elevated baseline peak coronary velocity may be caused by cardiac hypertrophy and anaemia in HD patients.
authors.affiliation: Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai 5-7-1, Suita 565-8565, Japan.
authors.forename: Shinnichiro
authors.initials: S
authors.lastname: Niizuma
authors.forename: Shin
authors.initials: S
authors.lastname: Takiuchi
authors.forename: Sadanori
authors.initials: S
authors.lastname: Okada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Horio
authors.forename: Kei
authors.initials: K
authors.lastname: Kamide
authors.forename: Hiroto
authors.initials: H
authors.lastname: Nakata
authors.forename: Fumiki
authors.initials: F
authors.lastname: Yoshihara
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakahama
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Iwanaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakatani
mesh_terms: D000368:Aged; D000740:Anemia / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D006435:Renal Dialysis; D014463:Ultrasonography