Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes.
BACKGROUND
Combinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania.


OBJECTIVE
To assess the efficacy and safety of olanzapine plus carbamazepine in mixed and manic bipolar episodes.


METHODS
Randomised, double-blind, 6-week trial of olanzapine (10-30 mg/day) plus carbamazepine (400-1200 mg/day; n=58) v. placebo plus carbamazepine (n=60) followed by open-label, 20-week olanzapine (10-30 mg/day) plus carbamazepine (400-1200 mg/day, n=86), with change in manic symptoms as main outcome measure. Safety and pharmacokinetics were also evaluated.


RESULTS
There were no significant differences (baseline to endpoint) in efficacy measures between treatment groups, but at 6 weeks triglyceride levels were significantly higher (P=0.008) and potentially clinically significant weight gain (>or=7%) occurred more frequently (24.6% v. 3.4%, P=0.002) in the combined olanzapine and carbamazepine group. Carbamazepine reduced olanzapine concentrations but olanzapine had no effect on carbamazepine concentrations.


CONCLUSIONS
The combination of olanzapine and carbamazepine did not have superior efficacy to carbamazepine alone. The increases in weight and triglycerides observed during combination treatment are a matter of concern.
Tohen
Mauricio
M
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA. m.tohen@lilly.com
Bowden
Charles L
CL
Smulevich
Anatoly B
AB
Bergstrom
Richard
R
Quinlan
Tonya
T
Osuntokun
Olawale
O
Wang
Wei V
WV
Oliff
Heather S
HS
Martenyi
Ferenc
F
Kryzhanovskaya
Ludmila A
LA
Greil
Waldemar
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002220:Carbamazepine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D016896:Treatment Outcome
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D002220:Carbamazepine; D000077152:Olanzapine