[Gene expression profile of the peripheral CD4(+)T cells in patients with RF(+) and RF(-) rheumatoid arthritis].
OBJECTIVE
To explore the differences of the gene expression of CD4(+) lymphocytes between the RF(+) and RF(-) patients with rheumatoid arthritis.


METHODS
mRNA of all the CD4(+) lymphocytes samples were extracted and identified. Then they were labeled and hybridized to microarrays.


RESULTS
Hierarchical clustering analysis showed there were 55 differential expression genes between the RF(+) and RF(-) patients with rheumatoid arthritis.


CONCLUSIONS
There are differential expression genes between the RF(+) and RF(-) patients and these genes are related to immunoresponse.
Lu
Cheng
C
Institute of Basic Research in Chinical Medicine, Beijing 100700, China. lv_cheng0816@163.com
Xu
Shi-jie
SJ
Xiao
Cheng
C
Yan
Xiao-ping
XP
Zhao
Lin-hua
LH
Wang
Jian-ming
JM
Li
Shao
S
Lu
Ai-ping
AP
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D012217:Rheumatoid Factor / Q000378:metabolism*; D055815:Young Adult
D012333:RNA, Messenger; D012217:Rheumatoid Factor