The STAR*D study: treating depression in the real world.
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner", it does provide guidance on how to start therapy and how to proceed if initial treatment fails.
Gaynes
Bradley N
BN
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599, USA. bgaynes@med.unc.edu
Rush
A John
AJ
Trivedi
Madhukar H
MH
Wisniewski
Stephen R
SR
Spencer
Donald
D
Fava
Maurizio
M
D000465:Algorithms; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D016896:Treatment Outcome
D000928:Antidepressive Agents; D015283:Citalopram