Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening.
Park
Hwangseo
H
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Korea. hspark@sejong.ac.kr
Jung
Suk-Kyeong
SK
Jeong
Dae Gwin
DG
Ryu
Seong Eon
SE
Kim
Seung Jun
SJ
D001665:Binding Sites / Q000187:drug effects; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004353:Drug Evaluation, Preclinical; D054640:Dual Specificity Phosphatase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D008024:Ligands; D054852:Small Molecule Libraries; D054640:Dual Specificity Phosphatase 3