title: A new generation of more pH stable reversed phases prepared by silanization of zirconized silica.
abstract: To further extend our studies in the search for reversed phases with enhanced durability at high pH, zirconized silica has now been explored as an alternative support. The synthesis of the new stationary phases involves silanization of a zirconium-modified silica support with a C(18) trifunctional silane, followed by endcapping. The chromatographic properties of the C(18) phases based on zirconized silica are similar to their titanized silica counterparts. Accelerated high pH stability tests, using phosphate mobile phases and elevated temperature, have shown that the zirconized silica phases have promising advantages not only over similarly prepared non-metalized phases but also over titanized silica C(18) phases.
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, Caixa Postal 6154, 13084-971 Campinas, São Paulo, Brazil.
authors.forename: César R
authors.initials: CR
authors.lastname: Silva
authors.forename: Claudio
authors.initials: C
authors.lastname: Airoldi
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Collins
authors.forename: Carol H
authors.initials: CH
authors.lastname: Collins
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D012821:Silanes / Q000138:chemical synthesis*; D012822:Silicon Dioxide / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013055:Spectrophotometry, Infrared; D015040:Zirconium / Q000737:chemistry*
chemical_list: D012821:Silanes; D012822:Silicon Dioxide; D015040:Zirconium