title: Soul searching and heart throbbing for biological modeling.
abstract: Biological models are useful not only because they can simulate biological behaviors, but because they may shed light on the inner workings of complex biological structures and functions as deduced by top-down and/or bottom-up reasoning. Beyond the stylistic appeal of specific implementation methods, a model should be appraised according to its ability to bring out the underlying organizing and operating principles - which are truly the model's heart and soul.
authors.affiliation: Division of Health Sciences and Technology, Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 dlyoung@mit.edu http://cybernet.mit.edu/
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Young
authors.forename: Chi-Sang
authors.initials: CS
authors.lastname: Poon