Extract of Pelargonium sidoides (EPs 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions.
EPs 7630 is an aqueous-ethanolic extract of the roots of PELARGONIUM SIDOIDES that displays well-documented benefits in the treatment of upper respiratory tract infections (URTI). IN VITRO and animal investigations have revealed various anti-infective properties of EPs 7630. The present review sums up recently published IN VITRO investigations that have shown positive effects on the activity of human peripheral blood phagocytes (PBP) and differential modulation of the interactions between group A streptococci and the host's epithelial barrier.
Conrad
Andreas
A
Institute of Environmental Medicine and Hospital Epidemiology, University Medical Center Freiburg, Freiburg, Germany. andreas.conrad@uniklinik-freiburg.de
Frank
Uwe
U
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D054884:Host-Pathogen Interactions / Q000187:drug effects*; D006801:Humans; D031316:Pelargonium; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000276:immunology
D000890:Anti-Infective Agents; C476332:EPs 7630; D010936:Plant Extracts