Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers.
Sedimentation velocity experiments show that only monomers coexist with amyloid fibrils of human islet amyloid-polypeptide. No oligomers containing <100 monomers could be detected, suggesting that the putative toxic oligomers are much larger than those found for the Alzheimer's peptide, Abeta(1-42).
Vaiana
Sara M
SM
Ghirlando
Rodolfo
R
Yau
Wai-Ming
WM
Eaton
William A
WA
Hofrichter
James
J
D000682:Amyloid / Q000032:analysis* / Q000737:chemistry*; D002498:Centrifugation / Q000379:methods*; D031521:Fractionation, Field Flow / Q000379:methods*; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008970:Molecular Weight; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000682:Amyloid; D058228:Islet Amyloid Polypeptide