title: [Dose-effect relationship between premature chromosome and irradiation dose].
abstract: OBJECTIVE
  To explore the dose-effect relationship between premature chromosome condensation induced by Calyculin A and irradiation dose.
  
  
  METHODS
  The human peripheral blood was irradiated by (137)Cs gamma radial. The irradiation dose included 0, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0 Gy. The premature chromosome condensation induced by Calyculin A was observed, and dyed by centromeric banding.
  
  
  RESULTS
  There was the quadratic relation between the total aberration, fragment, dicentric+centric ring (dic+r) ration and irradiation dose.
  
  
  CONCLUSIONS
  Premature chromosome condensation induced by Calyculin A can be used as a biodosimetry.
authors.affiliation: Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300020, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: En-Hai
authors.initials: EH
authors.lastname: Jiang
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Xing
authors.forename: Xin-Ran
authors.initials: XR
authors.lastname: Zhao
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002871:Chromosome Banding; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D008387:Marine Toxins; D010080:Oxazoles / Q000494:pharmacology; D055815:Young Adult
chemical_list: D008387:Marine Toxins; D010080:Oxazoles; C059041:calyculin A