title: Echinopines A and B: sesquiterpenoids possessing an unprecedented skeleton from Echinops spinosus.
abstract: Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOESY correlations and a simulation analysis. A plausible biosynthetic pathway for echinopane was discussed.
authors.affiliation: Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Bin
authors.initials: B
authors.lastname: Cong
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Yu
authors.forename: Françoise
authors.initials: F
authors.lastname: Sauriol
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Huo
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Lolita O
authors.initials: LO
authors.lastname: Zamir
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
mesh_terms: D004354:Drug Screening Assays, Antitumor; D031182:Echinops Plant / Q000737:chemistry*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; C527602:echinopine A; C527604:echinopine B