title: Low-cholesterol diet and antilipid therapy in managing tinnitus and hearing loss in patients with noise-induced hearing loss and hyperlipidemia.
abstract: The aim of our study was to outline the prevalence of hyperlipidemia in patients who had high-frequency hearing loss and tinnitus due to noise exposure. We investigated the role of a low-cholesterol diet and antihyperlipidemic therapy to alleviate the severity of tinnitus and possibly promote hearing gain after therapy in patients with acoustic trauma. Forty-two hyperlipidemic patients with subjective tinnitus and hearing loss due to noise exposure were enrolled for the study. We placed patients on a low-cholesterol diet or antihyperlipidemic therapy and followed them for up to 24 months; then we designated two groups as either "unresponsive" (n = 22; no response to either of the therapies and still experiencing hyperlipidemia) or "responsive" (n = 20; lower cholesterol or triglyceride levels). We then compared tinnitus scores and hearing levels in the two groups. The difference between tinnitus scores in the unresponsive and responsive groups and the change in tinnitus scores before and after therapy in the responsive group were significant. When we compared self-rated tinnitus severity results in two groups after therapy, we found the difference was significant (p < .05). The difference between average air-conduction thresholds at high frequencies after the treatment in the two groups was also significant. The incidence of hyperlipidemia is high among patients with noise-induced hearing loss, and significant improvement by way of lowered tinnitus intensity and higher frequencies in average hearing thresholds can be achieved after lowering the serum lipid level.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gulhane Military Medical School, Ankara, Turkey.
authors.forename: Aziz
authors.initials: A
authors.lastname: Sutbas
authors.forename: Sertac
authors.initials: S
authors.lastname: Yetiser
authors.forename: Bulent
authors.initials: B
authors.lastname: Satar
authors.forename: Timur
authors.initials: T
authors.lastname: Akcam
authors.forename: Serdar
authors.initials: S
authors.lastname: Karahatay
authors.forename: Kenan
authors.initials: K
authors.lastname: Saglam
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D005260:Female; D006317:Hearing Loss, Noise-Induced / Q000178:diet therapy / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000188:drug therapy / Q000453:epidemiology; D006949:Hyperlipidemias / Q000178:diet therapy / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D014012:Tinnitus / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000924:Anticholesteremic Agents