title: Basaloid squamous cell carcinoma of the soft palate: case report.
abstract: Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of squamous cell carcinoma. It occurs in various sites of the head and neck region and is believed to carry a dismal prognosis. The palate is a very rare site of BSCC development and only three cases have been reported in the international literature. In this report, we present a case of basaloid squamous cell carcinoma of the soft palate. The therapeutic strategy and histological findings are described in detail, including immunohistochemistry with the use of involucrin, an agent used for the first time for BSCC diagnosis. In addition, a brief review of the literature is presented.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.
authors.forename: A D
authors.initials: AD
authors.lastname: Karatzanis
authors.forename: G M
authors.initials: GM
authors.lastname: Fragkiadakis
authors.forename: E P
authors.initials: EP
authors.lastname: Prokopakis
authors.forename: A V
authors.initials: AV
authors.lastname: Koutsopoulos
authors.forename: E S
authors.initials: ES
authors.lastname: Helidonis
authors.forename: G A
authors.initials: GA
authors.lastname: Velegrakis
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002281:Carcinoma, Basosquamous / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D004396:Coloring Agents; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D010157:Palatal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D010160:Palate, Soft / Q000473:pathology / Q000601:surgery; D011498:Protein Precursors; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004396:Coloring Agents; D011498:Protein Precursors; C032253:involucrin