Insulin sensitivity and resistin levels in gestational diabetes mellitus and after parturition.
BACKGROUND
Resistin is expressed and secreted by the placenta during pregnancy. Increased serum resistin levels have been found in the second half of normal pregnancy, but its role in the pathogenesis of the insulin resistance of pregnancy is undetermined.


OBJECTIVE
The objective of the study was to assess the relationship between circulating resistin levels and insulin sensitivity in gestational diabetes mellitus (GDM).


METHODS
A case (n=23)-control (n=35) study was performed at the obstetrics and endocrinology clinic of a university hospital.


METHODS
In total, 58 Caucasian women with a singleton pregnancy who had been referred for a 100 g oral glucose tolerance test were enrolled between the weeks 26 and 30, and 22 women with GDM were also evaluated after pregnancy.


METHODS
Serum resistin and insulin sensitivity in GDM during and after pregnancy. The relationship of resistin to metabolic abnormalities was evaluated.


RESULTS
Resistin levels were lower in GDM women than in pregnant women with normal glucose tolerance (NGT) (4.32+/-1.56 vs 9.30+/-1.32 ng/ml, P<0.001), and experienced a further decrease after parturition (4.24+/-1.56 vs 3.11+/-1.63 ng/ml, P=0.003). The association between low serum resistin levels and the diagnosis of GDM was independent of the degree of insulin sensitivity.


CONCLUSIONS
Lower resistin levels were observed in GDM than in NGT women and decreased after parturition, suggesting a role for resistin in the development of this disease. But we have failed to find an independent relationship between resistin levels and insulin sensitivity during pregnancy.
Megia
Ana
A
Endocrinology and Diabetes Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, 43007, Tarragona, Spain. amc@comt.es
Vendrell
Joan
J
Gutierrez
Cristina
C
Sabaté
Modest
M
Broch
Montse
M
Fernández-Real
José-Manuel
JM
Simón
Inmaculada
I
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D009765:Obesity / Q000150:complications*; D010298:Parity; D049590:Postpartum Period; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D015430:Weight Gain
D001786:Blood Glucose; D007328:Insulin; D052243:Resistin