title: Total skin electron beam therapy may be associated with improvement of peripheral blood disease in Sézary syndrome.
abstract: Total skin electron beam radiation is an effective therapy for palliation of the cutaneous symptoms of the most common types of cutaneous T-cell lymphomas, mycosis fungoides and Sézary syndrome. We report 4 cases of patients with Sézary syndrome who had significant improvement in their blood burden of malignant cells in addition to complete cutaneous responses to total skin electron beam therapy. The data from these 4 patients illustrate the potential for total skin electron beam to be used as both a skin and blood tumor debulking agent, and not merely as a palliation for skin symptoms.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Camille E
authors.initials: CE
authors.lastname: Introcaso
authors.forename: Bizhan
authors.initials: B
authors.lastname: Micaily
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Richardson
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Junkins-Hopkins
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Yoon
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Kim
authors.forename: Carmela C
authors.initials: CC
authors.lastname: Vittorio
authors.forename: Alain H
authors.initials: AH
authors.lastname: Rook
mesh_terms: D016516:CD4-CD8 Ratio; D003131:Combined Modality Therapy; D004583:Electrons; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count; D016410:Lymphoma, T-Cell, Cutaneous / Q000532:radiotherapy*; D009182:Mycosis Fungoides / Q000532:radiotherapy; D012751:Sezary Syndrome / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013601:T-Lymphocytes / Q000528:radiation effects*; D014916:Whole-Body Irradiation