title: Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.
abstract: A yeast artificial chromosome (YAC) transgenic murine model of partial trisomy 21 overexpressing five human genes -- including DYRK1A, which encodes a serine threonine kinase involved in cell cycle control -- has been shown to present an increase in brain weight. We analyzed this new phenotype by measuring total and regional brain volumes at different ages, using a 7 Tesla magnetic resonance imaging volumetric approach. Volumetric measurements showed a total volume increase of 13.6% in adult mice. Changes in brain morphogenesis were already visible at a very early postnatal stage (postnatal days 2-7). Region-specific changes were characterized from postnatal day 15 to 5 months. These results, made it possible to define region-specific effects of DYRK1A overexpression, with the strongest increase seen in the thalamus-hypothalamus area (24%).
authors.affiliation: Laboratoire de RMN Biologique, ICSN-CNRS, Gif sur Yvette, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sebrié
authors.forename: Caroline
authors.initials: C
authors.lastname: Chabert
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ledru
authors.forename: Fayçal
authors.initials: F
authors.lastname: Guedj
authors.forename: Chrystelle
authors.initials: C
authors.lastname: Po
authors.forename: Desmond J
authors.initials: DJ
authors.lastname: Smith
authors.forename: Edward
authors.initials: E
authors.lastname: Rubin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rivals
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Beloeil
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gillet
authors.forename: Jean-Maurice
authors.initials: JM
authors.lastname: Delabar
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology / Q000473:pathology*; D018244:Chromosomes, Artificial, Yeast; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D007031:Hypothalamus / Q000201:enzymology / Q000473:pathology; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D051379:Mice; D008822:Mice, Transgenic; D009929:Organ Size; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D013788:Thalamus / Q000201:enzymology / Q000473:pathology; D015854:Up-Regulation; D000097603:Dyrk Kinases
chemical_list: D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases