[Expression of trophinin in human oocytes and preimplantation embryos].
OBJECTIVE
To investigate the significance of trophinin expression in human oocytes and preimplantation embryos.


METHODS
The expression of trophinin in 9 human oocytes, 16 blastomeres and 12 blastocysts were detected by indirect immunofluorescence assay and observed under laser scanning confocal microscope.


RESULTS
Human oocytes, blastomeres and blastocysts were all positive for trophinin expression, and the positivity intensified significantly in the course of the embryonic development (P<0.05).


CONCLUSIONS
Trophinin may play an important role in human embryo implantation by mediating homophilic adhesion between the embryo and the endometrium during the implantation window.
Wang
Hua-Yun
HY
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xing
Fu-Qi
FQ
Chen
Shi-Ling
SL
D001755:Blastocyst / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D018613:Microscopy, Confocal; D009865:Oocytes / Q000378:metabolism*; D011247:Pregnancy
D015815:Cell Adhesion Molecules; C093649:TRO protein, human