Effect of glialin on cardiac ventricular arrhythmias and myocardial conduction system in dogs.
Intravenous glialin in a dose of 7 mg/kg suppressed the number of ectopic contractions caused by double ligature of the left coronary artery by the method of Harris and almost 2-fold prolonged animal life-span in comparison with the control. The maximum antiarrhythmic effect of glialin developed after 180 min and persisted for 5 h. Glialin injected intravenously (10 mg/kg) after myocardial infarction under conditions of programmed electrical stimulation inhibited conduction of evoked impulse in the atria, Purkinje fibers, and ventricular myocardium and did not modify the effective refractory periods of the atria and ventricles.
Khisamutdinova
R Yu
RY
Laboratory of New Drugs, Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences.
Zarudii
F S
FS
Gabdrakhmanova
S F
SF
Makara
N S
NS
Baschenko
N Zh
NZh
Nazarov
V S
VS
D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004594:Electrophysiology; D019695:Glycyrrhizic Acid / Q000008:administration & dosage*; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D019695:Glycyrrhizic Acid; C051402:allapinin; D000157:Aconitine; C022150:lappaconitine