Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients.
OBJECTIVE
To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH(2)-terminal pro-brain natriuretic peptide (NT-proBNP).


METHODS
In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.


RESULTS
All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.


CONCLUSIONS
Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.
Astrup
Anne Sofie
AS
Steno Diabetes Center, Gentofte, Denmark. ansa@steno.dk
Kim
Won Yong
WY
Tarnow
Lise
L
Botnar
René M
RM
Simonsen
Cheryl
C
Brix
Lau
L
Pietraszek
Lotte
L
Hansen
Peter Riis
PR
Manning
Warren J
WJ
Parving
Hans-Henrik
HH
D000328:Adult; D017668:Age of Onset; D000419:Albuminuria; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D016277:Ventricular Function, Left
D003404:Creatinine; D006442:Glycated Hemoglobin; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76)