title: The role of antiendothelial cell antibodies in the development and follow-up of coronary and peripheral arterial diseases.
abstract: Occlusive lesions in the arterial endothelium are often caused by formation of intimal hyperplasia and fibrinoid necrosis. The objective of this study was to investigate the association between antiendothelial cell antibodies (AECAs) and the development of coronary artery disease (CAD) and peripheral artery disease (PAD). In this study, 94 patients with CAD or PAD and 94 healthy volunteers serving as control subjects were examined. Frozen sections of human umbilical vein endothelial cells and primate smooth muscle cells were used to detect the presence of AECAs, which were found in 52 of 94 patients (55%) and in 15 of 94 controls (16%) (P < .001). Endothelial structure tissue damage is a major factor in arterial diseases. In the present study, a statistically significant relationship was found between AECAs and the development of CAD and PAD. The presence of AECAs has been identified as a risk factor for these diseases. According to this study, AECAs are reliable prognosticators for the development of CAD and PAD. Further studies with large numbers of serum samples are under way.
authors.affiliation: Department of Cardiovascular Surgery, Baskent University, Ankara, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Aslim
authors.forename: Tankut
authors.initials: T
authors.lastname: Hakki Akay
authors.forename: Bilkay
authors.initials: B
authors.lastname: Bastürk
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozkan
authors.forename: Bahadir
authors.initials: B
authors.lastname: Gültekin
authors.forename: Salih
authors.initials: S
authors.lastname: Ozcobanoglu
authors.forename: Sale
authors.initials: S
authors.lastname: Sirvan
authors.forename: Sait
authors.initials: S
authors.lastname: Aslamaci
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000276:immunology*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000276:immunology*; D012307:Risk Factors
chemical_list: D001323:Autoantibodies