title: Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice.
abstract: We examine whether increased oxidative stress in vivo promotes telomere shortening in CAST/Ei mice. We explored the effects of L-buthionine sulfoximine treatment (BSO) on telomere length. BSO shortened telomere length in white fat, brown fat, skin, tail, and testis in concert with diminished tissue glutathione content, increased tissue carbonyl content, and increased plasma advanced oxidized protein products. Telomerase activity was mainly detected in testis but no reduction of telomerase activity was observed in response to BSO. In conclusion, BSO-mediated increase in systemic oxidative stress shortens telomeres in several tissues of the mouse. The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity.
authors.affiliation: Inserm, U684, 54500 Vandoeuvre-lès-Nancy, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Cattan
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mercier
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Gardner
authors.forename: Veronique
authors.initials: V
authors.lastname: Regnault
authors.forename: Carlos
authors.initials: C
authors.lastname: Labat
authors.forename: Jenni
authors.initials: J
authors.lastname: Mäki-Jouppila
authors.forename: Rosine
authors.initials: R
authors.lastname: Nzietchueng
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kimura
authors.forename: Abraham
authors.initials: A
authors.lastname: Aviv
authors.forename: Patrick
authors.initials: P
authors.lastname: Lacolley
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D051379:Mice; D009928:Organ Specificity; D018384:Oxidative Stress; D050050:Protein Carbonylation; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000187:drug effects / Q000648:ultrastructure*; D013737:Testis / Q000378:metabolism
chemical_list: D019328:Buthionine Sulfoximine; D019098:Telomerase; D005978:Glutathione