title: Prenatal drug exposure and teratological risk: one-year experience of an Italian Teratology Information Service.
abstract: BACKGROUND
  Concern about exposure to drugs, radiation, or infection during pregnancy occur often because pregnancy is not always planned. A teratology information service offers rapid scientific counseling to all those worried about prenatal exposure. The aim of this study is to present data on the most common pharmaceutical products responsible for teratogenic risk in the one-year experience of a teratology information service in Italy.
  
  
  METHODS
  The survey was conducted among 8664 callers who contacted our Teratology Information Service in Rome between January and December 2006. Data on maternal age, gravidity, parity, maternal health status, and details of exposure (dose and timing) were collected and stored in a specific data base. Scientific counseling on prenatal exposure was given to the caller by a specialized service operator, specifying the type of risk and suggesting appropriate tests for prenatal diagnosis.
  
  
  RESULTS
  Most of the people called regarding drug exposure; increased risk was present in only 5% of the pregnant women calling during pregnancy. Selective serotonin reuptake inhibitors (SSRIs) are the first category that are actually considered of increased risk to the fetus. The second category is represented by antiepileptic drugs.
  
  
  CONCLUSIONS
  This experience confirms previous data that there is a high teratological risk perception among both women and physicians. The drugs estimated to present increased risk are medications used for chronic neurological diseases, mainly mood disorders and epilepsy. Preconceptional counseling for these women could be an effective strategy to prevent such exposure and to improve maternal and fetal outcome.
authors.affiliation: Telefono Rosso-Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy. marcodesantis@rm.unicatt.it
authors.forename: Marco
authors.initials: M
authors.lastname: De Santis
authors.forename: Elena
authors.initials: E
authors.lastname: Cesari
authors.forename: Maria Serena
authors.initials: MS
authors.lastname: Ligato
authors.forename: Elena
authors.initials: E
authors.lastname: Nobili
authors.forename: Gianluca
authors.initials: G
authors.lastname: Straface
authors.forename: Annafranca
authors.initials: A
authors.lastname: Cavaliere
authors.forename: Alessandro
authors.initials: A
authors.lastname: Caruso
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects; D013956:Antithyroid Agents / Q000009:adverse effects; D003376:Counseling; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007255:Information Services / Q000706:statistics & numerical data; D007558:Italy; D018020:Lithium Compounds / Q000009:adverse effects; D018811:Maternal Exposure; D011247:Pregnancy; D011634:Public Health; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D013723:Teratogens / Q000633:toxicity*; D018600:Teratology / Q000706:statistics & numerical data
chemical_list: D000927:Anticonvulsants; D013956:Antithyroid Agents; D018020:Lithium Compounds; D017367:Selective Serotonin Reuptake Inhibitors; D013723:Teratogens