Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.
Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H(2)O(2)/TFE in presence of MeReO(3) as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.
Atheaya
Himanshu
H
Department of Chemistry, University of Delhi, Delhi 110007, India.
Khan
Shabana I
SI
Mamgain
Ritu
R
Rawat
Diwan S
DS
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002738:Chloroquine / Q000494:pharmacology; D004355:Drug Stability; D004912:Erythrocytes / Q000469:parasitology; D006358:Hot Temperature; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy; D010963:Plasmodium falciparum; D013329:Structure-Activity Relationship; D045568:Tetraoxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000962:Antimalarials; D001555:Benzene Derivatives; D045568:Tetraoxanes; D002738:Chloroquine