title: Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines.
abstract: Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined.
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, India.
authors.forename: R
authors.initials: R
authors.lastname: Ramajayam
authors.forename: Rajani
authors.initials: R
authors.lastname: Giridhar
authors.forename: Mange Ram
authors.initials: MR
authors.lastname: Yadav
authors.forename: Hakim
authors.initials: H
authors.lastname: Djaballah
authors.forename: David
authors.initials: D
authors.lastname: Shum
authors.forename: Constantin
authors.initials: C
authors.lastname: Radu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; D011743:Pyrimidines; C030986:pyrimidine