title: Repeat testing for congenital hypothyroidism in preterm infants is unnecessary with an appropriate thyroid stimulating hormone threshold.
abstract: BACKGROUND
  Revised UK neonatal screening guidelines recommend that a second blood sample for assay of thyroid stimulating hormone (TSH) be taken when preterm infants reach a postmenstrual age of 36 weeks.
  
  
  OBJECTIVE
  To examine the results of a regional screening programme to see whether a rise in TSH concentration was observed in some preterm infants between the first sample taken around 5 days after delivery and the second sample taken at around 36 weeks.
  
  
  METHODS
  Whole-blood TSH concentrations in preterm infants born over a 2-year period (April 2005 to March 2007) were assessed, and the number of infants in whom there was a fall or rise to values below or above the local screening threshold (6 mU/l) was determined.
  
  
  RESULTS
  Baseline TSH samples were obtained from 2238 preterm infants (median gestational age 32 weeks, range 21-35) with second samples obtained from 2039 (median gestational 32 weeks, range 23-35). In 19 infants, TSH concentrations fell from above to below the screening threshold, and in five infants values rose from below the screening threshold to 6-10 mU/l. However, TSH concentrations fell to <6 mU/l on a further blood spot in four of these infants, and the remaining infant had a serum TSH of 6.8 mU/l. Three infants had raised TSH concentrations on both occasions with unequivocal hypothyroidism (serum TSH >80 mU/l). The initial TSH concentration in one of these infants was 6-10 mU/l.
  
  
  CONCLUSIONS
  No infant with a normal TSH concentration on first sampling had a TSH concentration that rose above 10 mU/l on second sampling, and no infants with a normal TSH concentration on first screening are receiving long-term thyroxine treatment. This study suggests that a second sample may not be necessary with a screening threshold of 6 mU/l.
authors.affiliation: School of Clinical Medical Sciences (Child Health), Sir James Spence Institute, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.
authors.forename: M
authors.initials: M
authors.lastname: Korada
authors.forename: M S
authors.initials: MS
authors.lastname: Pearce
authors.forename: M P
authors.initials: MP
authors.lastname: Ward Platt
authors.forename: E
authors.initials: E
authors.lastname: Avis
authors.forename: S
authors.initials: S
authors.lastname: Turner
authors.forename: H
authors.initials: H
authors.lastname: Wastell
authors.forename: T
authors.initials: T
authors.lastname: Cheetham
mesh_terms: D003409:Congenital Hypothyroidism / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D012016:Reference Values; D013960:Thyroid Function Tests / Q000379:methods; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin