Serotonin is involved in the regulation of histogenetic processes in rat embryonic neocortex.
We compared the dynamics of the development of ectopic transplants of embryonic (day 14) primordial neocortex from rats injected with serotonin inhibitor (para-chlorophenylalanine; 400 mg/kg) on day 11 of pregnancy and transplants of similar primordial neocortex incubated before transplantation in a medium with serotonin (3 microg/ml). The study of mitotic activity and differentiation of transplanted cells showed that serotonin promoted survival of the transplanted neuroepithelial cells and their differentiation into nerve cells, and is involved in the regulation of their proliferation. We hypothesized that serotonin accelerated the cell cycle of transplanted cells, thus accelerating the neuron differentiation.
Petrova
E S
ES
Department of Morphology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Otellin
V A
VA
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D010134:Fenclonine / Q000008:administration & dosage; D016332:Fetal Tissue Transplantation; D005865:Gestational Age; D019579:Neocortex / Q000166:cytology / Q000187:drug effects / Q000196:embryology* / Q000637:transplantation; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000008:administration & dosage
D012702:Serotonin Antagonists; D012701:Serotonin; D010134:Fenclonine