title: Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults with down syndrome: a prospective case series.
abstract: BACKGROUND
  Subjects with Down syndrome (DS) experience a high prevalence of periodontal disease, and the management of this disease in subjects with DS is a challenge for oral health care providers. The purpose of this case series was to follow the periodontal healing response changes over a 12-month period after non-surgical mechanical periodontal therapy with the adjunctive use of chlorhexidine and monthly recalls in adults with DS who presented initially with chronic periodontitis.
  
  
  METHODS
  Twenty-one subjects with DS (14 males and seven females; 25.3 +/- 5.5 years of age) with reported mild-to-moderate learning disabilities and chronic periodontitis were recruited and treated by non-surgical mechanical periodontal therapy (followed by monthly recalls) and the adjunctive use of chlorhexidine gel for toothbrushing and chlorhexidine mouthwash twice daily. Clinical data were recorded.
  
  
  RESULTS
  After 12 months of non-surgical mechanical periodontal therapy, the mean percentage of sites with plaque decreased from 84.1% to 23.6%, and the mean number of sites with bleeding on probing decreased from 82.1% to 29.5%. Mean probing depth decreased from 3.2 to 1.8 mm, with a mean clinical attachment level gain of 0.6 mm.
  
  
  CONCLUSIONS
  Satisfactory healing responses were achieved following non-surgical mechanical periodontal therapy with the adjunctive use of chlorhexidine and monthly recalls in adults with DS with chronic periodontitis and mild-to-moderate learning disabilities. Such a treatment regimen seems appropriate and beneficial for adults with DS and chronic periodontitis.
authors.affiliation: Periodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: Ronald H W
authors.initials: RH
authors.lastname: Cheng
authors.forename: W Keung
authors.initials: WK
authors.lastname: Leung
authors.forename: Esmonde F
authors.initials: EF
authors.lastname: Corbet
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002710:Chlorhexidine / Q000008:administration & dosage*; D017742:Dental Care for Chronically Ill; D003773:Dental Plaque / Q000150:complications / Q000628:therapy; D012534:Dental Scaling; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use; D010518:Periodontitis / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D014100:Toothpastes / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D005782:Gels; D009067:Mouthwashes; D014100:Toothpastes; D002710:Chlorhexidine