WU polyomavirus in children with acute lower respiratory tract infections, China.
BACKGROUND
WU polyomavirus (WUPyV), a new member of the genus of Polyomavirus in the family Polyomaviridae, has been found and associated with respiratory tract infections recently. However, its clinical role and pathogenicity has not been known.


OBJECTIVE
To confirm that WU polyomavirus has been found in Chinese children.


METHODS
WU polyomavirus was detected and identified using PCR methods. A total of 278 specimens of nasopharyngeal aspirate were collected, and then PCR products were sequenced directly.


RESULTS
One of 278 nasopharyngeal aspirates was positive for WUPyV in one child, and the positive rate was 0.4%. The results showed that the sequences of genome, LTAg and VP2 gene was identical to the reference sequences of WU polyomavirus prototype strains.


CONCLUSIONS
We confirmed that WU polyomavirus had been found and identified in the respiratory secretions in China.
Lin
Feng
F
Wenzhou Medicine College, Wenling First Hospital, Wenling, Zhejiang Province, Wenling, China. linfengwyy@vip.sina.com
Zheng
Meiyun
M
Li
Hua
H
Zheng
Changhua
C
Li
Xuyang
X
Rao
Gaofeng
G
Zheng
Minqiao
M
Wu
Feng
F
Zeng
Aiping
A
D001483:Base Sequence; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D009305:Nasopharynx / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins