[Metabolic activity of peripheral blood neutrophils during treatment of children with acute lymphoblastic leukemia].
Neutrophilic metabolic activity was studied in 21 children with lymphoblastic leukemia during chemotherapy. After one-year chemotherapy, reduced cell activities of catalase and glutathione reductase were observed in children with septic complications during a follow-up in the presence of lower neutrophilic lactate levels. There was a direct correlation between lactate levels and catalase activity. Since the reduction in the levels of lactate in the neutrophils is attended by their apoptosis, this suggests that there is an association of delayed cell death with a fall in the phagocytic antioxidative defense potential.
Kratnov
A E
AE
Borisova
E V
EV
D000293:Adolescent; D002374:Catalase / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005980:Glutathione Reductase / Q000032:analysis*; D006801:Humans; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D009504:Neutrophils / Q000201:enzymology*; D018384:Oxidative Stress; D010587:Phagocytosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*
D019344:Lactic Acid; D002374:Catalase; D005980:Glutathione Reductase