title: Combined inherited thrombophilia and adverse pregnancy outcome.
abstract: Inherited thrombophilia has been suggested as a possible condition of increased susceptibility to adverse pregnancy outcomes. In our prospective study, we investigated the association between combined inherited thrombophilia and adverse pregnancy outcome in the South-Western Greek population. Three hundred and ninety-six healthy Greek women with spontaneous pregnancies were investigated for combinations of the three commonest thrombophilic mutations (Factor II G20210A, Factor V Leiden and MTHFR C677T) and followed for adverse pregnancy outcomes. Statistical analysis was performed by Pearson's chi-square test. Four women (1%) had the FV Leiden/MTHFR T677T double genotype and two women (0.5%) had the FII G20210A/MTHFR T677T double genotype. Although the small number of cases of combined inherited thrombophilia, it seems that the presence of FV Leiden/MTHFR T677T double genotype increases the risk for placental abruption.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Patras, Medical School, Rion, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Androutsopoulos
authors.forename: A
authors.initials: A
authors.lastname: Mougiou
authors.forename: M
authors.initials: M
authors.lastname: Karakantza
authors.forename: G
authors.initials: G
authors.lastname: Sakellaropoulos
authors.forename: G
authors.initials: G
authors.lastname: Kourounis
authors.forename: G
authors.initials: G
authors.lastname: Decavalas
mesh_terms: D000037:Abruptio Placentae / Q000235:genetics; D000328:Adult; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005838:Genotype; D006115:Greece; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000235:genetics* / Q000503:physiopathology*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)