Regulation of SIRT6 protein levels by nutrient availability.
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability.
Kanfi
Yariv
Y
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Shalman
Ronnie
R
Peshti
Victoria
V
Pilosof
Shmuel N
SN
Gozlan
Yosi M
YM
Pearson
Kevin J
KJ
Lerrer
Batya
B
Moazed
Danesh
D
Marine
Jean-Christophe
JC
de Cabo
Rafael
R
Cohen
Haim Y
HY
D000818:Animals; D002460:Cell Line; D005502:Food; D005508:Food Deprivation; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D051381:Rats; D011916:Rats, Inbred F344; D037761:Sirtuins / Q000378:metabolism*; D013816:Thermodynamics; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53; C501860:Sirt6 protein, mouse; C516592:SIRT6 protein, human; D037761:Sirtuins