title: Non-neurological surgery results in a neurochemical stress response.
abstract: There is a paucity of studies assessing changes in measures of human neurotransmission during stressful events, such as surgery. Thirty-five patients without any neurological disorders undergoing knee replacements with spinal bupivacaine anaesthesia and propofol sedation had cerebrospinal fluid (CSF) drawn from a spinal catheter before, three hours after and the morning after surgery. The CSF concentrations of the dopamine metabolite homovanillinic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), which are related to the activity of the dopaminergic and serotonergic systems of the brain, increased sharply during surgery and reached 188% and 166% of their initial concentrations on the morning after the intervention (p < 0.0001). The CSF concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglucol (MHPG) increased modestly (non-significantly) during and after surgery. The HVA/5-HIAA ratios initially increased but returned to the initial level during the night after surgery. We conclude that non-neurological surgery, in this case to the lower limb, is accompanied by a marked central nervous stress response in spite of a spinal blockade.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Kungälv Hospital, Kungälv, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Anckarsäter
authors.forename: H
authors.initials: H
authors.lastname: Zetterberg
authors.forename: J-E
authors.initials: JE
authors.lastname: Månsson
authors.forename: K
authors.initials: K
authors.lastname: Blennow
authors.forename: H
authors.initials: H
authors.lastname: Anckarsäter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal; D019645:Arthroplasty, Replacement, Knee / Q000523:psychology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D013312:Stress, Physiological / Q000134:cerebrospinal fluid* / Q000503:physiopathology
chemical_list: D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid