title: Adiponectin and metabolic syndrome in middle-aged and elderly Chinese.
abstract: OBJECTIVE
  Hypoadiponectinemia is an important risk factor for metabolic syndrome (MetS). However, little is known about its role in the Chinese population. The aim of this study was to investigate the association between plasma adiponectin levels and MetS in middle-aged and elderly Chinese from both urban and rural areas of northern and southern China.
  
  
  METHODS
  This population-based cross-sectional study included 3,193 subjects aged 50-70 from urban and rural areas of Beijing (northern China) and Shanghai (southern China). Plasma adiponectin concentrations were measured using a high-throughput micro-assay, Luminex. MetS was identified with the updated National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria.
  
  
  RESULTS
  Adiponectin levels were significantly higher in female, and rural subjects than in male or urban residents (P < 0.001). The prevalence and the number of MetS components progressively increased with declined adiponectin levels (P for trend <0.001). The participants in the lowest adiponectin quartile had a significantly increased risk for acquiring MetS (odds ratio (OR) 3.38, 95% confidence interval (CI) 2.56-4.46) after adjustment for potential confounders. Subjects from Beijing or rural areas had a higher risk for MetS at the same given level of adiponectin than did their Shanghai or urban counterparts, respectively.
  
  
  CONCLUSIONS
  Adiponectin is negatively associated with MetS in the middle-aged and elderly Chinese independent of known confounders such as BMI, physical activity and life habits. The urban-rural and northern-southern differences in susceptibility to MetS should be taken into consideration for the early detection and prevention of MetS.
authors.affiliation: Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Franco
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000367:Age Factors; D000368:Aged; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000208:ethnology; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population; D012727:Sex Characteristics; D014505:Urban Population
chemical_list: D052242:Adiponectin