title: Nonpenetrating very deep sclerectomy with reticulated hyaluronic acid implant in glaucoma treatment.
abstract: BACKGROUND
  The purpose of our study was to assess intraocular pressure control (IOP) and postoperative complications in nonpenetrating very deep sclerectomy (NPVDS) with reticulated hyaluronic acid implant (SKGEL) and Mitomycin C (MMC).
  
  
  METHODS
  Fifty eyes from fifty patients with medically uncontrolled glaucoma were randomized to either the NPVDS or NPDS group. The NPVDS procedure was similar to traditional NPDS (control group); however, excision of sclera and exposure of ciliary body were also performed, and only a narrow scleral flap was retained at a distance of 0.5 mm from Schlemm's canal. Mitomycin-C 0.2 mg/ml was applied on and under the superficial flap of the sclera during both NPVDS and NPDS. Follow-up examinations were carried out at 1 week, and then at 1, 3, 6, and 12 months after surgery. Success was defined as IOP <22 mmHg with or without glaucoma medication and laser procedures.
  
  
  RESULTS
  The 12-month success rate in the NPVDS group was 96%, not significantly higher than in the control group (88%, p=0.88). There was no statistically significant difference in IOP between the NPVDS (15.9+/-2.5 mmHg) and NPDS (16.3+/-3.6 mmHg) groups (p=0.57). Complications included four cases of hyphema, three of choroidal detachment (myopic eyes), and one of filtering bleb fibrosis in the NPVDS group, and three cases of hyphema, two of choroidal detachment (myopic eyes), and three of filtering bleb fibrosis in the NPDS group.
  
  
  CONCLUSIONS
  NPVDS is an effective surgical modality for patients with glaucoma. The safety of NPVDS is comparable to that of NPDS.
authors.affiliation: Department of Ophthalmology, Medical University of Silesia, Katowice, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Leszczyński
authors.forename: Stanislawa
authors.initials: S
authors.lastname: Gierek-Ciaciura
authors.forename: Maria
authors.initials: M
authors.lastname: Forminśka-Kapuścik
authors.forename: Ewa
authors.initials: E
authors.lastname: Mrukwa-Kominek
authors.forename: Iwona
authors.initials: I
authors.lastname: Rokita-Wala
mesh_terms: D000368:Aged; D004343:Drug Implants; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D012590:Sclera / Q000601:surgery*; D012599:Sclerostomy / Q000009:adverse effects / Q000379:methods*
chemical_list: D004343:Drug Implants; D016685:Mitomycin; D006820:Hyaluronic Acid