Polymorphism and solvatomorphism 2006.
Articles and patents that deal with polymorphism (crystal systems for which a substance can exist in structures characterized by different unit cells, but where each of the forms has exactly the same elemental composition) and solvatomorphism (systems where the crystal structures of the substance are defined by different unit cells, but where these unit cells differ in their elemental composition through the inclusion of one or molecules of solvent) have been summarized in an annual review. The works cited in this review were published during 2006, and were drawn from the major physical, crystallographic, and pharmaceutical journals. The review is divided into sections that cover articles of general interest, computational and theoretical studies, preparative and isolation methods, structural characterization and properties of polymorphic and solvatomorphic systems, studies of phase transformations, effects associated with secondary processing, and United States patents issued during 2006.
Brittain
Harry G
HG
Center for Pharmaceutical Physics, 10 Charles Road, Milford, New Jersey 08848, USA. hbrittain@centerpharmphysics.com
D003460:Crystallization; D015394:Molecular Structure; D013816:Thermodynamics