title: Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones.
abstract: A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramolecular N-arylation and an intermolecular Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones 3. The starting materials were synthesized by the Ugi four-component reaction. An unprecedented X-ray structure of bispalladacycle 6 was documented.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.
authors.forename: Angela
authors.initials: A
authors.lastname: Salcedo
authors.forename: Luc
authors.initials: L
authors.lastname: Neuville
authors.forename: Christophe
authors.initials: C
authors.lastname: Rondot
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001569:Benzodiazepines; D010165:Palladium