Genomic analysis of serotonin receptors in learning and memory.
The completion of the Human Genome Project and a variety of new technologies, such as DNA microarray technology, are revolutionizing the way molecular mechanisms underlying learning and memory can be explored. This review highlights the use of a genomic approach to dissect and analyze the complex dynamic interactions involved in gene regulation during learning and memory and illustrates the changes of serotonin receptor subtypes observed in different time domains and behavioral paradigms.
Cavallaro
Sebastiano
S
Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, 95123 Catania, Italy. s.cavallaro@isn.cnr.it
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D051381:Rats; D011985:Receptors, Serotonin / Q000235:genetics / Q000502:physiology*
D011985:Receptors, Serotonin