Cervical spondylodiscitis caused by Blastoschizomyces capitatus.
A 37-year-old woman, during her second remission of acute myeloid leukemia, presented with severe neck pain and cervico-brachial neuralgia. Investigation revealed a C5-C6 spondylodiscitis. A CT-guided anterior biopsy decompressed the mass, immediately alleviated the symptoms, and isolated a rare yeast: Blastoschizomyces capitatus. To our knowledge, only three cases of spondylodiscitis with this yeast have been described. Six months of voriconazole and liposomal amphotericin B treatment produced a complete resolution on CT and MRI imaging. However, the ongoing severe yeast infection prevented the planned bone marrow allograft.
Mejdoubi
M
M
Dept. of Neuroradiology, Purpan University Hospital, Toulouse, France.
Huynh
A
A
Danho
C
C
Boot
B
B
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000382:microbiology; D055157:Dipodascus / Q000302:isolation & purification*; D015299:Discitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D009333:Neck / Q000000981:diagnostic imaging; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use; D014463:Ultrasonography; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole