Dynamics of the structural and electrical characteristics of erythrocytes in men with metastatic adenocarcinoma of the prostate before and after plastic orchiectomy.
The changes of electrophoretic mobility of erythrocytes in the practically healthy men and in men with metastatic prostate cancer before and after castration were studied. The electrophoretic mobility of erythrocytes was investigated in laboratory conditions by Kharamanenko and Abramson micro methods. Experimental data were processed by means of standard variation statistics MINITAB (Basic statistic) p<or=0,05 was taken as statistically proved. Investigation revealed, that the level of electrophoretic mobility of erythrocytes was decreased in the blood of metastatic prostate cancer patients (before castration), as compared with control group and with post operational period data. Electrophoretic mobility of erythrocytes 4-6 months after castration was higher, as compared to preoperational period and approximately the same as in control group. It was found, that during the malignant adenocarcinoma of prostate (before and after surgery) pathological changes in organism effect erythrocytes superficial membranes and alter their electrical and structural parameters. This is reflected in changes of erythrocytes electrophoretic mobility. Probably, that is one of the reasons of considerable decrease of erythrocytes electrophoretic mobility in patients with metastatic prostate adenocarcinoma (before castration). Also, comparative normalization of erythrocytes electrophoretic mobility after castration and its approximation to the control group on this stage (4-6 months after castration) may be the reason that induces partial restoration of organism homeostasis.
Veshapidze
N
N
Iv Javakhishvili Tbilisi State University, Faculty of Exact and Natural sciences.
Chigogidze
T
T
Managadze
L
L
Gabunia
N
N
Kotrikadze
N
N
D000050:Acanthocytes / Q000378:metabolism / Q000648:ultrastructure; D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D000368:Aged; D001783:Blood Flow Velocity; D002465:Cell Movement; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D009919:Orchiectomy / Q000379:methods*; D011182:Postoperative Care; D011300:Preoperative Care; D011471:Prostatic Neoplasms / Q000556:secondary* / Q000601:surgery*