Effect of Lipo-PGE1 on health-related quality of life in patients with systemic sclerosis and systemic lupus erythematosus in Japan.
We investigated the effect of Lipo-PGE(1), a prostaglandin (PG) E(1) preparation used to treat cutaneous ulcers associated with systemic sclerosis (SS) and systemic lupus erythematosus (SLE), on health-related quality of life (HR-QOL) using the Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire. A total of 192 SS and SLE patients were treated for 3 months. At baseline the scores for each of the five SF-36 subscales were significantly lower than the age- and sex-adjusted standard values for the Japanese general population. After treatment, mean (+/- SD) SF-36 scores for body pain and general health perception significantly increased from 48.6 +/- 24.1 to 55.3 +/- 26.1 and from 36.8 +/- 16.7 to 40.2 +/- 17, respectively. Emotional QOL parameters including vitality and mental health, however, showed no improvement. Physician-rated symptom scores significantly improved after administration of Lipo-PGE(1). In conclusion, Lipo-PGE(1) improved both cutaneous ulcers and HR-QOL, especially physical QOL.
Hoshi
K
K
Institute of Medical Science, St Marianna University School of Medicine, Kanagawa, Japan. k_hoshi@ac.shoyaku.ac.jp
Fukuhara
S
S
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000527:Alprostadil / Q000627:therapeutic use*; D005260:Female; D006304:Health Status; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011788:Quality of Life; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology
D010975:Platelet Aggregation Inhibitors; D000527:Alprostadil