title: Over-the-counter medications for acute cough in children and adults in ambulatory settings.
abstract: BACKGROUND
  Acute cough due to upper respiratory tract infection (URTI) is a common symptom. Non-prescription over-the-counter (OTC) medicines are frequently recommended as a first-line treatment, but there is little evidence as to whether these drugs are effective.
  
  
  OBJECTIVE
  To assess the effects of oral OTC cough preparations for acute cough.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 4); MEDLINE (January 1966 to January Week 1, 2007); EMBASE (January 1974 to January 2007); and the UK Department of Health National Research Register (June 2007).
  
  
  METHODS
  Randomised controlled trials (RCTs) comparing oral OTC cough preparations with placebo in children and adults suffering from acute cough in ambulatory settings. We considered all cough outcomes and second outcomes of interest were adverse effects.
  
  
  METHODS
  Two review authors independently screened potentially relevant citations and independently extracted data and assessed study quality. Quantitative analysis was performed where appropriate.
  
  
  RESULTS
  Twenty five trials (17 in adults, 8 in children) involving 3492 people (2876 adults and 616 children) were included. RESULTS OF STUDIES IN ADULTS: Six trials compared antitussives with placebo and had variable results. Two trials compared the expectorant, guaifenesin with placebo, one indicated significant benefit whereas the other did not. One trial found that a mucolytic reduced cough frequency and symptom scores. Two studies examined antihistamine-decongestant combinations and found conflicting results. Three studies compared other combinations of drugs with placebo and indicated some benefit in reducing cough symptoms. Three trials found antihistamines were no more effective than placebo in relieving cough symptoms. RESULTS OF STUDIES IN CHILDREN: Antitussives (two studies), antihistamines (two studies), antihistamine decongestants (two studies) and antitussive/bronchodilator combinations (one study) were no more effective than placebo. No studies using expectorants met our inclusion criteria. The results of one trial favoured active treatment with mucolytics over placebo. One trial tested two paediatric cough syrups and both preparations showed a 'satisfactory response' in 46% and 56% of children compared to 21% of children in the placebo group.
  
  
  CONCLUSIONS
  There is no good evidence for or against the effectiveness of OTC medicines in acute cough. The results of this review have to be interpreted with caution due differences in study characteristics and quality. Studies often showed conflicting results with uncertainty regarding clinical relevance. Higher quality evidence is needed to determine the effectiveness of self-care treatments for acute cough.
authors.forename: S M
authors.initials: SM
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Schroeder
authors.forename: T
authors.initials: T
authors.lastname: Fahey
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000553:Ambulatory Care; D000996:Antitussive Agents / Q000008:administration & dosage*; D002648:Child; D003371:Cough / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005100:Expectorants / Q000008:administration & dosage; D006634:Histamine H1 Antagonists / Q000008:administration & dosage; D006801:Humans; D004366:Nonprescription Drugs / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000996:Antitussive Agents; D005100:Expectorants; D006634:Histamine H1 Antagonists; D004366:Nonprescription Drugs