Changed activity of the hypothalamic-pituitary-adrenocortical system in prenatally stressed female rat during aging.
We studied the effects of daily 1-h immobilization of female rats on days 15-18 of pregnancy on functional activity of the hypothalamic-pituitary-adrenocortical system and its sensitivity to regulatory signals realized by the negative feedback mechanism in female progeny during aging. Prenatal stress potentiated the inhibitory processes in young animals. In aging female rats, the sensitivity of the hypothalamic-pituitary-adrenocortical system to feedback signals significantly decreased and circadian stress reactivity was disturbed. These data suggest that maternal stress modifies the age-related pattern of the hypothalamic-pituitary-adrenocortical regulation in female progeny.
Pivina
S G
SG
Laboratory of neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Akulova
V K
VK
Ordyan
N E
NE
D000375:Aging / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D025461:Feedback, Physiological; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D012149:Restraint, Physical / Q000502:physiology
D003345:Corticosterone