title: Adenomyoepithelioma of the breast diagnosed by a mammotome biopsy: report of a case.
abstract: Adenomyoepithelioma is an uncommon primary breast tumor. It is conspicuous for two elements of the tumor, namely, ductal and myoepithelial components. Recently, a Mammotome biopsy, or stereotactic vacuum-assisted biopsy has become popular and various benign or borderline lesions are obtained. We report an adenomyoepithelioma of the breast in a 56-year-old woman. She was pointed out to have a cluster of some microcalcifications on mammography and a 9-mm hypoechoic mass lesion was detected by ultrasound. A Mammotome biopsy revealed a well-defined lesion. Histologically, the tumor demonstrated a thick and bi-cellular growth pattern consisting of ducts and myoepithelium. Immunohistochemically, epithelial cells were positive for cytokeratin AE1/AE3 and cytokeratin, epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA), negative for alpha-smooth muscle actin (alpha-SMA). In addition, myoepithelial cells were positive for alpha-SMA and CEA, which were scatterly positive for cytokeratin AE1/AE3, and negative for EMA. In examinations of non-palpable lesions found on mammography and ultrasound, a Mammotome biopsy is useful for making diagnosis, however, and adenomyoepithelioma is rarely found. In diagnosing such a rare disease from the limited information obtained from a needle biopsy, an immunohistochemical study was thus found to be useful for making a differential diagnosis.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yahara
authors.forename: Rin
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Goro
authors.initials: G
authors.lastname: Yokoyama
authors.forename: Miki
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Shino
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Uhi
authors.initials: U
authors.lastname: Toh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Fujii
mesh_terms: D018194:Adenomyoma / Q000000981:diagnostic imaging / Q000473:pathology*; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009208:Myoepithelioma / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013238:Stereotaxic Techniques