title: [Randomized multicenter control clinical study on acute ischemic stroke treatment with traditional Chinese medicine].
abstract: OBJECTIVE
  To observe the effect of a comprehensive protocol of integrated Chinese and Western medicine (ICWM) in treating with acute ischemic stroke.
  
  
  METHODS
  A multi-center, prospective, random and control clinical trial was adopted with 606 patients of acute ischemic stroke. They were divided into the treatment group (274 cases) treated with ICWM protocol, and the control group (263 cases) treated with Western medicine plus placebe, and BI, mRS were assessed after treatment.
  
  
  RESULTS
  Compared with the control group, the 90th day assessment showed that the severe disability rate was lower (BI <75) (P <0.05), the complete reabilitation and mild disability rate (BI> or =95, P < 0.05), and the disability level (modified Rankin scale mRS) were improved (P <0.05) in the treatment group than those in the control group.
  
  
  CONCLUSIONS
  The ICWM protocol used in this study may improve neural function and quality of life of acute ischemic stroke patients, and reduce the severe disability rate in those after 90 days treatment.
authors.affiliation: The First Department of Neurology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China.
authors.forename: Ye-feng
authors.initials: YF
authors.lastname: Cai
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Guo
authors.forename: Jin-song
authors.initials: JS
authors.lastname: You
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Wei-xiong
authors.initials: WX
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Pei-xin
authors.initials: PX
authors.lastname: Huang
mesh_terms: D000208:Acute Disease; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011446:Prospective Studies; D011788:Quality of Life; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D001241:Aspirin