title: The effects of rutaecarpine on the pharmacokinetics of acetaminophen in rats.
abstract: Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study. When 25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the area under the curve of APAP in plasma was significantly decreased when compared to that of APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3 days, the % value of C(max) and area under the curve of acetaminophen-sulfate conjugate were significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of APAP in rats.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea.
authors.forename: Sang Kyu
authors.initials: SK
authors.lastname: Lee
authors.forename: Sudeep R
authors.initials: SR
authors.lastname: Bista
authors.forename: Hemin
authors.initials: H
authors.lastname: Jeong
authors.forename: Dong Hyeon
authors.initials: DH
authors.lastname: Kim
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kang
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D000818:Animals; D019388:Cytochrome P-450 CYP1A2 / Q000096:biosynthesis; D003580:Cytochromes; D004347:Drug Interactions; D026121:Indole Alkaloids / Q000494:pharmacology*; D008297:Male; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D052999:Quinazolinones
chemical_list: D000082:Acetaminophen; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes; D026121:Indole Alkaloids; D011799:Quinazolines; C028632:rutecarpine; D052999:Quinazolinones; C017170:Cyp1a2 protein, rat