[Effects of centipede extract on life span of drosophila].
OBJECTIVE
To evaluate effects of centipede on life span of drosophila and on the appearance of the filial generation.


METHODS
Drosophila melanogaster (male and female) were cultured in tubes with centipede extraction at concentrations of 0, 0.2%, 1%, 2.5%, or 5% until all drosophila died. The appearance of the filial generation were observed.


RESULTS
The life span, including average, longest and shortest life span was shortened in exposed groups of both sexes and significantly dose-dependent. The appearance of the filial generation showed normal.


CONCLUSIONS
Centipede extracts accelerates the aging of drosophila and shortens their life span. The appearance of the filial generation is not affected. Clinic using centipede for a long period should be carefully.
Cui
Xiao-dong
XD
School of Chinese Material Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
Wang
Chao-ran
CR
Zhang
Chang-qing
CQ
Duan
Yu-long
YL
Zhang
Li
L
Wang
Chun-mei
CM
D000818:Animals; D001181:Arthropods / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology; D008136:Longevity / Q000187:drug effects*; D008419:Materia Medica / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D008419:Materia Medica