Effect of atmospheric ammonia on mortality rate of rats with barbiturate intoxication.
Ammonia inhalation (0.84-1.07 mg/liter, 3 h) was accompanied by a 65% increase in ammonia concentration in mixed blood of intact rats. This treatment did not cause death of intact animals, but potentiated the lethal effect of sodium thiopental and inhibited external respiration and O2 consumption in animals. The resistance of rats to the lethal effect of barbiturate tended to decrease under conditions of experimental hyperammonemia induced by intraperitoneal injection of ammonium acetate in a nonlethal dose (6 mmol/kg). Our results indicate that potentiation of the toxic effect of barbiturates by atmospheric ammonia is related to its resorptive effects.
Rejniuk
V L
VL
Military Medical Academy, St. Petersburg. vladton@mail.ru
Schafer
T V
TV
Ovsep'yan
R V
RV
Ivnitsky
J J
JJ
D000085:Acetates / Q000494:pharmacology; D000280:Administration, Inhalation; D000641:Ammonia / Q000097:blood / Q000633:toxicity*; D000818:Animals; D004357:Drug Synergism; D005260:Female; D022124:Hyperammonemia / Q000139:chemically induced; D010101:Oxygen Consumption / Q000187:drug effects; D011041:Poisoning / Q000401:mortality; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013874:Thiopental / Q000506:poisoning*
D000085:Acetates; D000641:Ammonia; D013874:Thiopental; C018824:ammonium acetate