title: Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus.
abstract: Two sesquiterpenes, corymbolone and mustakone, isolated from the chloroform extract of the rhizomes of Cyperus articulatus, exhibited significant anti-plasmodial properties. Mustakone was approximately ten times more active than corymbolone against the sensitive strains of the Plasmodium falciparum.
authors.affiliation: Kenya Medical Research Institute (KEMRI), PO BOX 54840, Nairobi, Kenya. grukunga@kemri.org
authors.forename: G M
authors.initials: GM
authors.lastname: Rukunga
authors.forename: F W
authors.initials: FW
authors.lastname: Muregi
authors.forename: S A
authors.initials: SA
authors.lastname: Omar
authors.forename: J W
authors.initials: JW
authors.lastname: Gathirwa
authors.forename: C N
authors.initials: CN
authors.lastname: Muthaura
authors.forename: M G
authors.initials: MG
authors.lastname: Peter
authors.forename: M
authors.initials: M
authors.lastname: Heydenreich
authors.forename: G M
authors.initials: GM
authors.lastname: Mungai
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029786:Cyperus; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes