S100B protein and its clinical effect on craniocerebral injury.
OBJECTIVE
To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury.


METHODS
In this study, we reviewed the domestic and foreign research reports about the relationship between S100B protein and craniocerebral injury.


RESULTS
The concentration of S100B protein had a different increase based on the degree of injury in early stage after craniocerebral injury, and the increasing degree of S100B protein showed a positive correlation with the grading of pathogenetic condition and prognosis of craniocerebral injury.


CONCLUSIONS
S100B protein may be taken as a specific index of early diagnosis, grading of pathogenetic condition, and prognosis judgement after craniocerebral injury. To grasp and regulate the mechanism of neurotoxicity and to elucidate the therapeutic effect of S100B protein will be a research direction in clinical treatment of craniocerebral injury.
Yuan
Xue-song
XS
Department of Neurosurgery, Affiliated Wujin Hospital, Jiangsu University, Wujin 213002, China. cedar.y@163.com
Bian
Xiao-xing
XX
D006259:Craniocerebral Trauma / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human