Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA.
We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)(2A) receptor function in the form of 5-HT(2A) receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT(2A) receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT(2A) receptor mRNA levels may be involved in this phenomenon.
Kitamura
Yoshihisa
Y
Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. ykita@pharm.okayama-u.ac.jp
Fujitani
Yoshika
Y
Kitagawa
Kouhei
K
Miyazaki
Toshiaki
T
Sagara
Hidenori
H
Kawasaki
Hiromu
H
Shibata
Kazuhiko
K
Sendo
Toshiaki
T
Gomita
Yutaka
Y
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D016642:Bupropion / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013550:Swimming / Q000523:psychology*
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D012333:RNA, Messenger; D044402:Receptor, Serotonin, 5-HT2A; D016642:Bupropion; D000324:Adrenocorticotropic Hormone; D007099:Imipramine