Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.
Krueger
A Chris
AC
Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com
Xu
Yibo
Y
Kati
Warren M
WM
Kempf
Dale J
DJ
Maring
Clarence J
CJ
McDaniel
Keith F
KF
Molla
Akhteruzzaman
A
Montgomery
Debra
D
Kohlbrenner
William E
WE
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D011759:Pyrrolidines; D009439:Neuraminidase