A ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas.
When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway. Alternative pathways for iron assimilation, such as those involving ZIP family transporters IRT1 and IRT2, may be operational.
Chen
Jen-Chih
JC
Department of Chemistry and Biochemistry, Box 951569, University of California-Los Angeles, Los Angeles, CA 90095-1569, USA.
Hsieh
Scott I
SI
Kropat
Janette
J
Merchant
Sabeeha S
SS
D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism; D002570:Ceruloplasmin / Q000235:genetics / Q000378:metabolism*; D016825:Chlamydomonas reinhardtii / Q000201:enzymology / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism
D027682:Cation Transport Proteins; D026901:Membrane Transport Proteins; D007501:Iron; D002570:Ceruloplasmin