Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients.
OBJECTIVE
To assess the effect of the aromatase inhibitor on patients with leiomyoma in the reproductive stage regarding reduction of uterine volume and control of symptoms.


METHODS
Clinical study.


METHODS
Academic clinical practice.


METHODS
Twenty patients, over 35 years of age, with symptomatic uterine leiomyoma.


METHODS
Anastrozol, 1 mg/day for 12 weeks.


METHODS
Measurement of uterine volume, assessment of symptoms related to uterine leiomyoma, serum assay of follicle stimulating hormone (FSH), and estradiol.


RESULTS
Average reduction of uterine volume of 9.32%, attaining up to 32%, and reduction of symptoms of uterine leiomyoma (menstrual volume, duration of menstruation, and dysmenorrhea). No significant change in serum levels of FSH and estradiol during use of the medication were observed.


CONCLUSIONS
Anastrozol proved to be effective in reducing the volume of the uterus-leiomyoma structure, leading to the control of symptoms connected with the disorder without changes in serum FSH and estradiol.
Hilário
Sandro G
SG
Department of Obstetrics and Gynecology, University of São Paulo Medical School, São Paulo, Brazil. sandrohilario@hotmail.com
Bozzini
Nilo
N
Borsari
Rodrigo
R
Baracat
Edmund C
EC
D000328:Adult; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D008598:Menstruation / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D047648:Perimenopause; D014230:Triazoles / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy*
D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D004958:Estradiol; D005640:Follicle Stimulating Hormone