title: Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients.
abstract: OBJECTIVE
  To assess the effect of the aromatase inhibitor on patients with leiomyoma in the reproductive stage regarding reduction of uterine volume and control of symptoms.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  Academic clinical practice.
  
  
  METHODS
  Twenty patients, over 35 years of age, with symptomatic uterine leiomyoma.
  
  
  METHODS
  Anastrozol, 1 mg/day for 12 weeks.
  
  
  METHODS
  Measurement of uterine volume, assessment of symptoms related to uterine leiomyoma, serum assay of follicle stimulating hormone (FSH), and estradiol.
  
  
  RESULTS
  Average reduction of uterine volume of 9.32%, attaining up to 32%, and reduction of symptoms of uterine leiomyoma (menstrual volume, duration of menstruation, and dysmenorrhea). No significant change in serum levels of FSH and estradiol during use of the medication were observed.
  
  
  CONCLUSIONS
  Anastrozol proved to be effective in reducing the volume of the uterus-leiomyoma structure, leading to the control of symptoms connected with the disorder without changes in serum FSH and estradiol.
authors.affiliation: Department of Obstetrics and Gynecology, University of São Paulo Medical School, São Paulo, Brazil. sandrohilario@hotmail.com
authors.forename: Sandro G
authors.initials: SG
authors.lastname: Hilário
authors.forename: Nilo
authors.initials: N
authors.lastname: Bozzini
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Borsari
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000328:Adult; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D008598:Menstruation / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D047648:Perimenopause; D014230:Triazoles / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D004958:Estradiol; D005640:Follicle Stimulating Hormone