Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?
Numerous individuals and institutions throughout the world have contributed to the development of hematopoietic stem cell transplantation (HSCT) for autoimmune diseases. In this review, we will summarize what we have learned at our own institution (Northwestern University), and how it has guided our therapy. An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases.
Burt
Richard K
RK
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. rburt@northwestern.edu
Testori
Alessandro
A
Testor
Alessandro
A
Craig
Robert
R
Cohen
Bruce
B
Suffit
Robert
R
Barr
Walter
W
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D036102:Peripheral Blood Stem Cell Transplantation; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous
D016207:Cytokines; D007166:Immunosuppressive Agents