Point-mutation effects on charge-transport properties of the tumor-suppressor gene p53.
We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.
Shih
Chi-Tin
CT
Department of Physics, Tunghai University, 40704 Taichung, Taiwan.
Roche
Stephan
S
Römer
Rudolf A
RA
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D016158:Genes, p53; D008956:Models, Chemical; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D017354:Point Mutation
D004247:DNA