Postprandial dysmetabolism: the missing link between diabetes and cardiovascular events?
OBJECTIVE
To investigate the association of postprandial dysmetabolism, ie, hyperglycemia, and hyperlipidemia with myocardial disease in diabetic, glucose-intolerant, and glucose-tolerant patients.


METHODS
We performed a MEDLINE search of the English-language literature published between January 1979 and April 2007 for studies regarding postprandial dysmetabolism and heart disease.


RESULTS
Postprandial dysmetabolism is associated with increased inflammation, endothelial dysfunction, decreased fibrinolysis, plaque instability, and cardiac events.


CONCLUSIONS
There is a direct and proportional association between postprandial dysmetabolism and both coronary artery disease and cardiac events.
Bell
David S H
DS
Southside Endocrinology, Birmingham, Alabama 35205, USA. dshbell@yahoo.com
O'Keefe
James H
JH
Jellinger
Paul
P
D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism; D001786:Blood Glucose / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism*; D048909:Diabetes Complications / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D006949:Hyperlipidemias / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D019518:Postprandial Period
D001786:Blood Glucose