A notch sweeter.
Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.
Irvine
Kenneth D
KD
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA. irvine@waksman.rutgers.edu
D000483:Alleles; D000818:Animals; D002384:Catalysis; D004330:Drosophila / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins; D017353:Gene Deletion; D005786:Gene Expression Regulation; D017344:Genes, Insect; D005820:Genetic Testing; D005947:Glucose / Q000378:metabolism; D005964:Glucosyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006031:Glycosylation; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D015398:Signal Transduction; D013696:Temperature
D029721:Drosophila Proteins; D051880:Receptors, Notch; D012694:Serine; D005964:Glucosyltransferases; D005947:Glucose