Effectiveness of Danning Tablet in patients with non-alcoholic fatty liver of damp-heat syndrome type: a multicenter randomized controlled trial.
OBJECTIVE
To evaluate the efficacy and safety of Danning Tablet (DNT) in patients with non-alcoholic fatty liver disease (NAFLD) of damp-heat syndrome type.


METHODS
A multicenter, randomized, double-blinded and positive drug parallel controlled trial was performed. One hundred and thirty-five patients were enrolled into the study and divided into two groups: DNT-treated group (n=102) and ursodeoxycholic acid (UDCA)-treated group (n=33). Body mass index (BMI), principal symptoms, liver function, blood lipids, iconographic, and compositional parameters were measured before and after treatment, respectively.


RESULTS
In the two groups, BMI, distress in hepatic region, fatigue, anorexia, liver function, blood lipids and iconographic parameters were significantly improved, and the improvements of BMI, distress in hepatic region were better in DNT-treated group than in UDCA-treated group. The histological study also showed that DNT had positive effect in treatment of NAFLD.


CONCLUSIONS
DNT is an effective drug to treat patients with NAFLD of damp-heat syndrome type and is more effective than UDCA.
Ji
Guang
G
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. jiliver@vip.sina.com
Fan
Jian-Gao
JG
Chen
Jian-Jie
JJ
Lu
Lun-Gen
LG
Xing
Lian-Jun
LJ
Zheng
Pei-Yong
PY
Gu
Hong-Gang
HG
Wei
Hua-Feng
HF
You
Sheng-Fu
SF
Zhu
Pei-Ting
PT
D000328:Adult; D015992:Body Mass Index; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005234:Fatty Liver / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D008055:Lipids