title: Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients.
abstract: OBJECTIVE
  To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH(2)-terminal pro-brain natriuretic peptide (NT-proBNP).
  
  
  METHODS
  In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.
  
  
  RESULTS
  All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.
  
  
  CONCLUSIONS
  Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.
authors.affiliation: Steno Diabetes Center, Gentofte, Denmark. ansa@steno.dk
authors.forename: Anne Sofie
authors.initials: AS
authors.lastname: Astrup
authors.forename: Won Yong
authors.initials: WY
authors.lastname: Kim
authors.forename: Lise
authors.initials: L
authors.lastname: Tarnow
authors.forename: René M
authors.initials: RM
authors.lastname: Botnar
authors.forename: Cheryl
authors.initials: C
authors.lastname: Simonsen
authors.forename: Lau
authors.initials: L
authors.lastname: Brix
authors.forename: Lotte
authors.initials: L
authors.lastname: Pietraszek
authors.forename: Peter Riis
authors.initials: PR
authors.lastname: Hansen
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Manning
authors.forename: Hans-Henrik
authors.initials: HH
authors.lastname: Parving
mesh_terms: D000328:Adult; D017668:Age of Onset; D000419:Albuminuria; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D016277:Ventricular Function, Left
chemical_list: D003404:Creatinine; D006442:Glycated Hemoglobin; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76)