Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention.
The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.
Parsons
J Thomas
JT
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA jtp@virginia.edu
Slack-Davis
Jill
J
Tilghman
Robert
R
Roberts
W Gregory
WG
D000970:Antineoplastic Agents / Q000627:therapeutic use; D018450:Disease Progression; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000235:genetics; D015398:Signal Transduction
D000970:Antineoplastic Agents; D016023:Integrins; D016376:Oligonucleotides, Antisense; D047428:Protein Kinase Inhibitors; D034741:RNA, Small Interfering; D051416:Focal Adhesion Protein-Tyrosine Kinases