title: The enantioselective total synthesis of a beta-carboline alkaloid, (S)-(-)-dichotomine C.
abstract: The first enantioselective synthesis of a beta-carboline alkaloid, dichotomine C, possessing antiallergic effects, was achieved by constructing a beta-carboline framework based on the microwave-assisted thermal electrocyclic reaction of a 1-azahexatriene system, followed by the Sharpless asymmetric dihydroxylation.
authors.affiliation: Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Omura
authors.forename: Tominari
authors.initials: T
authors.lastname: Choshi
authors.forename: Shiroh
authors.initials: S
authors.lastname: Watanabe
authors.forename: Yuhsuke
authors.initials: Y
authors.lastname: Satoh
authors.forename: Junko
authors.initials: J
authors.lastname: Nobuhiro
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hibino
mesh_terms: D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002243:Carbolines / Q000138:chemical synthesis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003500:Cyclization; D006900:Hydroxylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008872:Microwaves; D013237:Stereoisomerism
chemical_list: D018926:Anti-Allergic Agents; D002243:Carbolines; D007202:Indicators and Reagents; C527322:dichotomine C