Cancer chemopreventive activity of terpenoid coumarins from Ferula species.
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV-EA activation and preserved the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents (IC (50) 8.3 and 9.1 nM, respectively). Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids.
Iranshahi
Mehrdad
M
Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Iranshahim@mums.ac.ir
Kalategi
Farhad
F
Rezaee
Ramin
R
Shahverdi
Ahmad Reza
AR
Ito
Chihiro
C
Furukawa
Hiroshi
H
Tokuda
Harukuni
H
Itoigawa
Masataka
M
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D005309:Ferula / Q000737:chemistry*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D003374:Coumarins; D010936:Plant Extracts; D013729:Terpenes