title: Multiple unilateral adrenal adenomas in a patient with primary hyperaldosteronism.
abstract: OBJECTIVE
  To report a rare case of multiple unilateral adrenal adenomas in which immunohistochemistry results confirmed primary hyperaldosteronism in each of 3 adenomas.
  
  
  METHODS
  We present the clinical, laboratory, radiographic, and pathologic findings of a case of multiple unilateral adrenal adenomas.
  
  
  RESULTS
  Although multiple nodules in both adrenal glands are fairly common in patients with bilateral hyperplasia, multiple unilateral nodules are extremely rare. A 45-year-old woman with a long-standing history of severe hypertension was found to have biochemical parameters consistent with primary hyperaldosteronism, multiple unilateral adrenal adenomas, and immunohistochemical test results confirming primary hyperaldosteronism arising from each of 3 adrenal nodules (measuring 2.2 x 2.2 cm, 1.7 x 0.7 cm, and 0.5 x 0.5 cm).
  
  
  CONCLUSIONS
  This case illustrates the rare presentation of primary hyperaldosteronism as multiple unilateral adrenal adenomas in which immunohistochemistry results can confirm the suspected preoperative diagnosis as suggested by biochemical and radiographic evidence.
authors.affiliation: Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts 02118, USA. Angela.Leung@bmc.org
authors.forename: Angela M
authors.initials: AM
authors.lastname: Leung
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nishikwa
authors.forename: David B
authors.initials: DB
authors.lastname: McAneny
authors.forename: Alan O
authors.initials: AO
authors.lastname: Malabanan
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006973:Hypertension / Q000209:etiology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000150:complications
chemical_list: D000450:Aldosterone