Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (group B streptococcus), Haemophilus ducreyi, and vaginal Lactobacillus by 3-O-octyl-sn-glycerol.
The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.
Moncla
B J
BJ
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. bjm4@pitt.edu
Pryke
K
K
Isaacs
Charles E
CE
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D005260:Female; D005995:Glyceryl Ethers / Q000737:chemistry / Q000494:pharmacology*; D006191:Haemophilus ducreyi / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000254:growth & development; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000254:growth & development; D014621:Vagina / Q000382:microbiology
C490932:1-O-octyl-sn-glycerol; D000900:Anti-Bacterial Agents; D005995:Glyceryl Ethers