Co-existence of fatty acids changes in aorta artery and adipose tissue; comparison between CAD and non CAD patients.
BACKGROUND
This study was aimed to evaluate composition and possible co-existence of change in fatty acids of aorta artery and adipose tissue in two groups of patients with different degree of atherosclerosis.


METHODS
Twenty-one angiographically documented coronary artery diseases (CAD) patients, and the same numbers of age, sex and body mass index-matched angiographically documented non CAD patients enrolled in this study. They were operated electively for coronary artery bypass grafting (CABG) or aortic valve replacement surgery (AVR), respectively. Small segments of ascending aorta artery and adipose tissue were dissected form the two groups during open heart surgery and subjected to fatty acid analysis.


RESULTS
The results showed that in the CAD group, amounts of saturated and omega6 unsaturated fatty acids were higher, while the percent of monounsaturated and omega3 unsaturated fatty acids were lower than the non CAD patients for both aorta artery and adipose tissue samples. A moderate correlation was seen between amounts of fatty acids in adipose tissue and aorta artery.


CONCLUSIONS
As there are many reports which show that adipose tissue can only be used as a suitable indicator of dietary intake of exogenous fatty acids (e.g. polyunsaturated and trans fatty acids), our study suggests that modification of fatty acids with endogenous synthesis and metabolism (e.g. saturated and monounsaturated fatty acids) which were observed in both adipose tissue and aorta artery of CAD patients, may be produced during atherogenesis.
Bahrami
Gholamreza
G
Medical Biology Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran. gbahrami@kums.ac.ir
Masoumi
Masoumali
M
Rahimi
Zoherh
Z
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000367:Age Factors; D001011:Aorta / Q000737:chemistry*; D050197:Atherosclerosis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis*; D005229:Fatty Acids, Monounsaturated / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000032:analysis; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged
D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated