title: PET kinetic analysis: error consideration of quantitative analysis in dynamic studies.
abstract: Positron emission tomography dynamic studies have been performed to quantify several biomedical functions. In a quantitative analysis of these studies, kinetic parameters were estimated by mathematical methods, such as a nonlinear least-squares algorithm with compartmental model and graphical analysis. In this estimation, the uncertainty in the estimated kinetic parameters depends on the signal-to-noise ratio and quantitative analysis method. This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models.
authors.affiliation: Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, 565-8565, Japan. ikoma@ri.ncvc.go.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ikoma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watabe
authors.forename: Miho
authors.initials: M
authors.lastname: Shidahara
authors.forename: Mika
authors.initials: M
authors.lastname: Naganawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D049268:Positron-Emission Tomography / Q000379:methods*; D011865:Radioisotope Dilution Technique; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity