[Botulism has not disappeared].
BACKGROUND
Botulism is a potentially fatal infectious disease induced by a neurotoxin secreted by Clostridium botulinum, a sporulated species of obligate anaerobic bacteria. This neurotoxin inhibits the normal release of acetylcholine in the synaptic cleft, inducing presynaptic neuromuscular blockade. The diagnosis is often difficult because of the range and the lack of specificity of the symptoms.


METHODS
We report two cases of human botulism. The first case was easy to diagnose, with dysphagia, dysphonia, blurred vision, and xerostomia, associated with potentiation on electromyogram and B botulinum toxin in the serum. Symptoms in the second case included diplopia, blurred vision, dysphagia, dysphonia, with potentiation on electromyogram but no botulinum toxin.


CONCLUSIONS
These two cases remind us of the necessity to keep botulism in mind when systemic atropinic symptoms are found together with generalized, progressive and extensive paralysis. The diagnosis is confirmed by electromyogram and serology. There is no specific treatment for botulism; only intensive care surveillance and symptomatic treatment improve survival.
Gentil
Arnaud
A
Service de neurologie, CHU de Dijon, F-21000 Dijon, France.
Soichot
Pierre
P
Maugras
Cécile
C
Lemesle-Martin
Martine
M
Béjot
Yannick
Y
Rouaud
Olivier
O
Osseby
Guy-Victor
GV
Fromont
Agnès
A
Couvreur
Grégory
G
Moreau
Thibault
T
Giroud
Maurice
M
D000328:Adult; D001905:Botulinum Toxins / Q000097:blood; D001906:Botulism / Q000175:diagnosis*; D003680:Deglutition Disorders / Q000382:microbiology; D004576:Electromyography; D006801:Humans; D008297:Male; D014786:Vision Disorders / Q000382:microbiology; D014832:Voice Disorders / Q000382:microbiology; D014987:Xerostomia / Q000382:microbiology
D001905:Botulinum Toxins