title: Preservation of the mitral valve apparatus: evidence synthesis and critical reappraisal of surgical techniques.
abstract: Sub-valvular apparatus preservation after mitral valve replacement is not a new concept, yet to date there has been no quantification of its clinical effectiveness as a procedure and no consensus as to which surgical preservation technique should be adopted to achieve the best immediate and midterm clinical outcomes. This systematic review of current available literature aims to use an evidence synthesis and meta-analytic approach to compare outcomes following replacement of the mitral valve with (MVR-P) or without preservation (MVR-NP) of its apparatus. It considers all the relevant anatomical, experimental, echocardiographic, and clinical studies published in the literature and appraises all reported mitral valve sub-valvular apparatus preservation techniques. The results of this review strongly suggest that MVR-P is superior to MVR-NP with regards to the incidence of early postoperative low-cardiac output requiring inotropic support, and early or mid-term survival. They also suggest that the operative decision should be individualised based on patient's anatomy, pathology and ventricular function and therefore surgeons should be familiar with more than one surgical preservation technique. Finally, this paper highlights the need for further high quality research focusing particularly on the long-term assessment of quality of life and health utility following MVR-P.
authors.affiliation: Department of Cardiothoracic Surgery, St. Mary's Hospital, London, UK. tathan5253@aol.com
authors.forename: Thanos
authors.initials: T
authors.lastname: Athanasiou
authors.forename: Andre
authors.initials: A
authors.lastname: Chow
authors.forename: Christopher
authors.initials: C
authors.lastname: Rao
authors.forename: Omer
authors.initials: O
authors.lastname: Aziz
authors.forename: Fotios
authors.initials: F
authors.lastname: Siannis
authors.forename: Ayyaz
authors.initials: A
authors.lastname: Ali
authors.forename: Ara
authors.initials: A
authors.lastname: Darzi
authors.forename: Francis
authors.initials: F
authors.lastname: Wells
mesh_terms: D000818:Animals; D002815:Chordae Tendineae / Q000601:surgery; D004285:Dogs; D006349:Heart Valve Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control; D013552:Swine; D014463:Ultrasonography; D016276:Ventricular Function / Q000502:physiology