title: Evaluation of the medicinal potentials of the methanol extracts of the leaves and stems of Halleria lucida.
abstract: The medicinal potentials of the methanol extracts of the leaves and stems of Halleria lucida (Scrophulariaceae) were evaluated by assessing their antibacterial and antioxidant properties in vitro using standard procedures. The antioxidant activities of methanol extract of the leaves as determined by the ABTS, DPPH, proanthocyanidins and total flavonoids were higher than that of the stem. On the other hand, the total phenols, the flavonoids and the FRAP contents of the stem were higher than that of the leaves. The extracts however showed poor activity against both Gram-positive and Gram-negative bacteria. The methanol extract of the stem showed activities against Bacillus cereus and Staphylococcus epidermidis at MIC of 1.0 mg/ml. The methanol extract of the leaves did not show activity against any of the organisms used in this study. This study has to some extent validated the medicinal potential of the leaves and stems of H. lucida.
authors.affiliation: ARDRI, University of Fort Hare, Alice 5700, South Africa.
authors.forename: A A
authors.initials: AA
authors.lastname: Adedapo
authors.forename: F O
authors.initials: FO
authors.lastname: Jimoh
authors.forename: S
authors.initials: S
authors.lastname: Koduru
authors.forename: P J
authors.initials: PJ
authors.lastname: Masika
authors.forename: A J
authors.initials: AJ
authors.lastname: Afolayan
mesh_terms: D000975:Antioxidants / Q000032:analysis; D001409:Bacillus cereus / Q000378:metabolism; D001681:Biological Assay; D001709:Biotechnology / Q000379:methods*; D001713:Biphenyl Compounds / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers; D006834:Hydrazines / Q000032:analysis; D008826:Microbial Sensitivity Tests; D015233:Models, Statistical; D019800:Phenol / Q000032:analysis; D010851:Picrates; D010936:Plant Extracts / Q000032:analysis* / Q000378:metabolism; D018515:Plant Leaves / Q000378:metabolism*; D018547:Plant Stems / Q000378:metabolism*; D013212:Staphylococcus epidermidis / Q000378:metabolism; D014197:Trees
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D010936:Plant Extracts; D019800:Phenol; C004931:1,1-diphenyl-2-picrylhydrazyl