title: Soluble but not platelet P-selectin correlates with spontaneous platelet aggregation: a pilot study.
abstract: BACKGROUND
  P-selectin (PS) is a marker of platelet activation measured on the platelet surface as platelet PS (pPS) or in serum as soluble PS (sPS). Controversy remains over the exact relationship between sPS, pPS, and other markers such as spontaneous platelet aggregation (SPA).
  
  
  OBJECTIVE
  To investigate correlations between pPS, sPS, and SPA in patients with peripheral arterial disease.
  
  
  METHODS
  SPA, pPS, and sPS levels were measured in venous blood sampled from patients following intermittent claudication (n = 18) or an acute stroke (n = 18).
  
  
  RESULTS
  SPA and sPS correlated significantly in the claudicants (Pearson correlation coefficient, r = 0.661; P = .0020) and stroke patients (r = 0.514; P = .020). No significant correlation was identified between pPS and SPA, or sPS and pPS.
  
  
  CONCLUSIONS
  The 2 methods of assessing PS are not comparable. Although pPS is accepted as a platelet activation marker, sPS may be a better indicator of aggregation represented by SPA.
authors.affiliation: Department of Vascular Surgery, Queen Elizabeth Hospital, Gateshead, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Cleanthis
authors.forename: Jonathan
authors.initials: J
authors.lastname: Smout
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Bhattacharya
authors.forename: Hamdy
authors.initials: H
authors.lastname: Ashour
authors.forename: Alexander
authors.initials: A
authors.lastname: Dyker
authors.forename: Gary Ashley
authors.initials: GA
authors.lastname: Ford
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Gerard Patrick
authors.initials: GP
authors.lastname: Stansby
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000737:chemistry*; D002545:Brain Ischemia / Q000097:blood; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D015539:Platelet Activation; D010974:Platelet Aggregation; D020521:Stroke / Q000097:blood
chemical_list: D019007:P-Selectin