title: Abnormal hypermyelination in a neonate with Sturge-Weber syndrome demonstrated on diffusion-tensor imaging.
abstract: In Sturge-Weber syndrome in neonates, evaluation of the extent of the brain parenchymal involvement is difficult due to the lack of calcification, although it is important for initiation of preventive antiepileptic treatment and prediction of prognosis. We present the first application of diffusion-tensor imaging with fractional anisotropy and ADC maps in a 7-day-old neonate. Abnormal T2 hypointensity in the subcortical white matter corresponded to the areas of increased FA and decreased ADC on diffusion-tensor imaging, which probably represents abnormal hypermyelination. Diffusion-tensor imaging enabled to quantify the abnormal hypermyelination, and is useful in early diagnosis of Sturge-Weber syndrome.
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. moritani2001@yahoo.com
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.forename: Jinsuh
authors.initials: J
authors.lastname: Kim
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Daniel
authors.initials: D
authors.lastname: Bonthius
authors.forename: Wendy R K
authors.initials: WR
authors.lastname: Smoker
mesh_terms: D001921:Brain / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009186:Myelin Sheath / Q000473:pathology*; D013341:Sturge-Weber Syndrome / Q000175:diagnosis*