title: Mild-to-moderate active luminal Crohn's disease.
abstract: The management of luminal Crohn's disease, the most common form of initial presentation of the disease, depends on the location and the severity of the disease. Mild-to-moderate disease represents a relatively large proportion of patients with a first flare of luminal disease, which may also be associated with perianal disease. As quality of life of these patients inversely correlates with disease activity, adequate therapy is a central goal of the overall patient management. Treatment options include mainly sulfasalazine, budesonide and systemic steroids, while the role of mesalazine and antibiotics remains controversial. The role of biological therapies has not been thoroughly evaluated in patients with mild disease.
authors.affiliation: Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. pierre.michetti@chuv.ch
authors.forename: Pierre
authors.initials: P
authors.lastname: Michetti
authors.forename: Pascal
authors.initials: P
authors.lastname: Juillerat
authors.forename: Christian
authors.initials: C
authors.lastname: Mottet
authors.forename: Valérie
authors.initials: V
authors.lastname: Pittet
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Gonvers
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Vader
authors.forename: Florian
authors.initials: F
authors.lastname: Froehlich
authors.forename: Christian
authors.initials: C
authors.lastname: Felley
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D018450:Disease Progression; D019317:Evidence-Based Medicine; D006801:Humans; D015994:Incidence; D019804:Mesalamine / Q000627:therapeutic use; D015995:Prevalence; D011788:Quality of Life; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine