title: [Preparation and anti-oxidative activity of liposomal ferulic acid].
abstract: Ferulic acid (FA) was loaded into liposomes via calcium acetate gradient with (80.2 +/- 5.2)% entrapment efficiency. The average sizes of blank liposome and FA liposome were about 155 nm and 154 nm, respectively. The zeta potential of blank liposome and FA liposome were (13.14 +/- 1.67) mV and (4.12 +/- 0.05) mV, respectively. Unilamellar vesicles were present in freeze-fracture electron microscopy. In the pharmacodynamic studies, the protective effect of liposomal ferulic acid on tBHP-challenged U937 cells was measured with the morphology of cell injury, mitochondrial transmembrane potential alternation and cell viability assay used as index. The results of MTT assay, microscopy indicated that FA liposomes exhibited greater antioxidant activity than FA solution on U937 cell.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. qinjingx@sina.com
authors.forename: Jing
authors.initials: J
authors.lastname: Qin
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Chen
authors.forename: Qiao
authors.initials: Q
authors.lastname: Cui
authors.forename: Ming-xi
authors.initials: MX
authors.lastname: Qiao
authors.forename: Hai-yang
authors.initials: HY
authors.lastname: Hu
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D002784:Cholesterol / Q000737:chemistry; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000502:physiology; D010316:Particle Size; D020298:U937 Cells
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D004337:Drug Carriers; D008081:Liposomes; D002784:Cholesterol; C004999:ferulic acid