Fluorescein sodium-guided surgery in glioblastoma multiforme: a prospective evaluation.
We have evaluated the influence of fluorescein-guided resection on gross total resection (GTR) and survival in a series of patients with GBM. Group 1 consisted of 47 patients given fluorescein and group 2 comprised 33 patients, on whom fluorescein was not used. Median survival time was 43.9 weeks in the patients given fluorescein and was 41.8 weeks in the non-fluorescein group. There was no statistically significant difference in survival between the two groups. However, the extent of resection had a powerful influence on the median survival time. Survival was 34.3 weeks after partial resection and 46.5 after GTR. Our data shows that the use of fluorescein injection is a simple procedure, which allows a significant increase in the number of patients having GTR (83 vs. 55%). Our findings are similar to a recently published multicentre Phase III randomized trial in which 5-aminolevulinic acid was used to facilitate resection of malignant glioma.
Koc
K
K
Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. kenankoc01@yahoo.com
Anik
I
I
Cabuk
B
B
Ceylan
S
S
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy; D003287:Contrast Media; D005260:Female; D019793:Fluorescein; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015641:Radiography, Interventional; D016019:Survival Analysis; D016896:Treatment Outcome
D003287:Contrast Media; D019793:Fluorescein