[Predisposition to autoimmune thyroid diseases within a Tunisian multiplex family].
The autoimmune thyroid diseases (AITDs) are multifactorial diseases which result from interplays between predisposing genes and triggering environmental factors. In order to study the genetic susceptibility factors to AITDs, we have followed up 115 control members belonging to a large Tunisian family with a high prevalence of AITDs (Akr family) during 15 years between 1990 to 2005. The follow-up of these control members have showed that 13 subjects (11.3%) developed AITDs (G2). The Hashimoto thyroiditis was the most frequently seen in 77% of the cases, whereas the Graves's disease was present in 23% of the cases. One hundred and two members remained controls (G1). High female predominance was noted in the two groups. The mean age of the G1 subjects group was slightly higher than that of G2. The prevalence of positive antithyroglobulin antibody (TgAb) and antithyroperoxydase antibody (TPOAb) was more frequent in G2 group (P=0.27 and P=0.23) respectively. The HLA haplotypes was realized in 42% of control members. The most frequent HLA haplotypes that were found were B37, DRB11 and A1. HLA B37 and DRB11 were significantly more frequent for the patients of G2 (P=0.0001 and P=0.034) respectively. Our study confirms the contribution of the genetic factors in the development of AITDs in 'Akr' family and suggested that the members of this family share the same genetic inheritance.
Charfi
N
N
Service d'endocrinologie, CHU Hédi-Chaker de Sfax, avenue Majida-Boulila 3029 Sfax, Tunisie.
Chabchoub
G
G
Mnif
M
M
Elleuch Bougacha
N
N
Jouida
J
J
Ayadi
H
H
Abid
M
M
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D006680:HLA Antigens / Q000032:analysis; D050031:Hashimoto Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
D001323:Autoantibodies; D006680:HLA Antigens; D013963:Thyroid Hormones; D013972:Thyrotropin