Chromatin regulation by AML1 complex.
The AML1 gene is the most frequent target of chromosomal translocations in acute leukemias. AML1 is essential for definitive hematopoiesis and regulates transcription of its target genes by binding to the specific DNA sequence. AML1 forms large multiprotein complexes including CBFbeta as a "core component" as well as several classes of chromatin modulators such as p300/CBP, MOZ, PML and HIPK2 as "regulatory complex". In this review, we describe the mechanisms by which AML1 complex regulates gene transcription and hematopoiesis, and its disruption by the leukemia-associated chromosomal translocations that affect genes for components of AML1 complex in view of deregulation of chromatin structure.
Yoshida
Hitoshi
H
Molecular Oncology Division, National Cancer Center Research Institute, Chuo-Ku, Tokyo 104-0045, Japan.
Kitabayashi
Issay
I
D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000502:physiology; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics; D051548:Histone Acetyltransferases / Q000235:genetics / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics*; D014178:Translocation, Genetic
D002352:Carrier Proteins; D002843:Chromatin; D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human; D051548:Histone Acetyltransferases; C108712:KAT6A protein, human; C115114:HIPK2 protein, human; D017346:Protein Serine-Threonine Kinases