[Continuous intraspinal ceftazidime administration in a case for treatment of purulent meningitis].
OBJECTIVE
To investigate the feasibility of continuous intraspinal ceftazidime administration for treatment of purulent meningitis due to Achromobacter infection.


METHODS
A patient with established diagnosis of purulent meningitis due to Achromobacter infection was admitted, who failed to respond favorably to a 3-day ceftazidime treatment administered intravenously. Continuous intraspinal ceftazidime administration at the dose of 0.2 g/d was then attempted through a catheter placed in the cisterna magna in addition to intravenous ceftazidime for 3 days, which resulted in obvious relief of the symptoms. The catheter was subsequently withdrawn, and the patient received further treatment with additional intravenous ceftazidime for a week.


RESULTS
The symptoms of purulent meningitis was significantly improved after a 3-day continuous intraspinal ceftazidime administration, and the patient was eventually cured after completion of the treatment course. Intrathecal ceftazidime was also attempted previously but failed due to intolerance of pains in the legs. No relapse was observed in this case 3 months after the discharge.


CONCLUSIONS
Continuous intraspinal ceftazidime administration can be effective and safe for treatment of purulent meningitis.
Yin
Jia
J
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yinjiajia@263.net
Lü
Tian-ming
TM
Liu
Xiao-jia
XJ
Wang
Qun
Q
Pan
Su-yue
SY
D042402:Achromobacter; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D002442:Ceftazidime / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002442:Ceftazidime