title: Early death in children with acute lymphoblastic leukemia: does malnutrition play a role?
abstract: The study aim was to correlate malnutrition and early death in children with acute lymphoblastic leukemia (ALL). A study was conducted in 100 consecutive children with ALL. An analysis included clinical and laboratory parameters as well as co-morbidity factors. Forty patients were standard risk and 60 high risk. Multivariate analysis showed variables of statistical importance, including female gender (p 010), ALL high-risk (p 04), and infection (p 036). Malnutrition (p 1.0) and poverty (p 0.5) did not influence. Early mortality was documented in 15/100 (15%) patients. The study shows that high-risk ALL and infection represent the leading causes of early mortality.
authors.affiliation: Division of Hem-Oncology, National Institute of Pediatrics (Instituto Nacional de Pediatría), Mexico City, Mexico. riveraluna@infosel.net.mx
authors.forename: Roberto
authors.initials: R
authors.lastname: Rivera-Luna
authors.forename: Alberto
authors.initials: A
authors.lastname: Olaya-Vargas
authors.forename: Martha
authors.initials: M
authors.lastname: Velásquez-Aviña
authors.forename: Silvestre
authors.initials: S
authors.lastname: Frenk
authors.forename: Rocío
authors.initials: R
authors.lastname: Cárdenas-Cardós
authors.forename: Carlos
authors.initials: C
authors.lastname: Leal-Leal
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-González
authors.forename: Armando
authors.initials: A
authors.lastname: Martínez-Avalos
mesh_terms: D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections; D008297:Male; D044342:Malnutrition / Q000401:mortality*; D009026:Mortality; D011203:Poverty; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000401:mortality*; D012307:Risk Factors; D012737:Sex Factors