Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial.
OBJECTIVE
The majority of endometrial cancer survivors (ECS) are obese and at risk for premature death. The purpose of this study was to assess feasibility of a lifestyle intervention program for promoting weight loss, change in eating behaviors, and increased physical activity in obese ECS.


METHODS
Early stage ECS (n=45) were randomized to a 6-month lifestyle intervention (LI; n=23) or usual care (UC; n=22). The LI group received group and individual counseling for 6 months. The primary endpoint was weight change. Secondary endpoints were physical activity, [Leisure score index (LSI)] and nutrient intake (3-day food records). Quantitative vitamin C and folate intake were used to assess fruit/vegetable intake.


RESULTS
Recruitment was 29%, adherence (LI group) was 73% and 84% of participants completed follow-up assessments. At 12 months, the intervention group lost 3.5 kg compared to a 1.4 kg gain in the control group [mean difference=-4.9 kg; 95% CI: -9.0 to -0.9 kg; p=.018] and had an increased LSI score of 16.4 versus -1.3 in the control group from baseline [mean group difference=17.8; 95% CI=7.1 to 28.4; p=.002]. There were no differences in vitamin C and folate intake. The LI group had lower intake of kilocalories, although differences were not significant.


CONCLUSIONS
A lifestyle intervention program in obese ECS is feasible and can result in sustained behavior change and weight loss over a 1-year period.
von Gruenigen
Vivian E
VE
University Hospitals Case Medical Center, Division of Gynecologic Oncology, 11100 Euclid Avenue, Room 7128, Cleveland, Ohio 44106, USA. vivian.vongruenigen@UHhospitals.org
Courneya
Kerry S
KS
Gibbons
Heidi E
HE
Kavanagh
Mary Beth
MB
Waggoner
Steven E
SE
Lerner
Edith
E
D004032:Diet; D004435:Eating; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D009367:Neoplasm Staging; D015596:Nutrition Assessment; D009765:Obesity / Q000150:complications / Q000628:therapy*; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D015431:Weight Loss