title: Nodular lymphocyte-predominant Hodgkin lymphoma presenting as fulminant hepatic failure in a pediatric patient: a case report with pathologic, immunophenotypic, and molecular findings.
abstract: A 7-year-old boy presented with fulminant hepatic failure requiring liver transplant. Serologic testing ruled out infectious and autoimmune causes. During transplant surgery he was found to have enlarged periportal lymph nodes that were biopsied. Nodular lymphocyte-predominant Hodgkin lymphoma was diagnosed based on histologic examination of the lymph node and liver. The L&H cells within the lymph node were positive for CD20 whereas those within the liver were not, although they were positive for other B-cell markers. After extensive work-up, the cause of liver failure could only be attributed to the involvement by lymphoma. In addition, B-cell clonality was established among the neoplastic cells with the same clone detected in all sampled tissues. Hodgkin lymphoma as a cause of hepatic failure is rare and has not been previously reported in a pediatric patient.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA.
authors.forename: Kirsten M W
authors.initials: KM
authors.lastname: Woolf
authors.forename: Michael C
authors.initials: MC
authors.lastname: Wei
authors.forename: Michael P
authors.initials: MP
authors.lastname: Link
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Arber
authors.forename: Roger A
authors.initials: RA
authors.lastname: Warnke
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002648:Child; D006689:Hodgkin Disease / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008099:Liver / Q000737:chemistry / Q000473:pathology; D017114:Liver Failure, Acute / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D016031:Liver Transplantation; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008297:Male
chemical_list: D018951:Antigens, CD20; D015415:Biomarkers