One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives.
A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98- >99 ee).
Vesely
Jan
J
Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm (Sweden).
Rios
Ramon
R
Ibrahem
Ismail
I
Zhao
Gui-Ling
GL
Eriksson
Lars
L
Córdova
Armando
A
D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003508:Cycloheptanes / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008958:Models, Molecular; D015394:Molecular Structure; D012015:Reference Standards; D013237:Stereoisomerism
D003508:Cycloheptanes