title: Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
abstract: Antitubercular drug induced hepatotoxicity is a major hurdle for an effective treatment of tuberculosis. The present study was undertaken to assess the hepatoprotective potential of tocopherol (50 mg/kg and 100 mg/kg, ip) and to compare it with cimetidine (120 mg/kg, ip). Hepatotoxicity was produced by giving isoniazid (INH, 50 mg/kg, po) and rifampicin (RMP, 100 mg/kg, po) combination to albino rabbits for 7 days. Assessment of liver injury was done by estimating levels of alanine transaminase (ALT) and argininosuccinic acid lyase (ASAL) in serum and by histopathological examination of liver. Results revealed that pretreatment with high dose of tocopherol (100 mg/kg) prevented both biochemical as well as histopathological evidence of hepatic damage induced by INH and RMP combination. Moreover, tocopherol (100 mg/kg) was found to be a more effective hepatoprotective agent as compared to cimetidine.
authors.affiliation: Department of Pharmacology, Maulana Azad Medical College, New Delhi, 110 002, India. vandana_muskan@rediffmail.com
authors.forename: Vandana
authors.initials: V
authors.lastname: Tayal
authors.forename: Bhupinder Singh
authors.initials: BS
authors.lastname: Kalra
authors.forename: Sarita
authors.initials: S
authors.lastname: Agarwal
authors.forename: Nita
authors.initials: N
authors.lastname: Khurana
authors.forename: Usha
authors.initials: U
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000502:physiology*; D000995:Antitubercular Agents / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007538:Isoniazid / Q000633:toxicity; D008107:Liver Diseases / Q000517:prevention & control; D011817:Rabbits; D012293:Rifampin / Q000633:toxicity; D024505:Tocopherols / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D002927:Cimetidine; D024505:Tocopherols; D007538:Isoniazid; D012293:Rifampin