Voltammetric determination of terbinafine in biological fluid at glassy carbon electrode modified by cysteic acid/carbon nanotubes composite film.
The electrochemical oxidation of L-cysteine (CySH) in presence of carbon nanotubes (CNTs) formed a composite film at a glassy carbon electrode (GCE) as a novel modifier for directly electroanalytical determination of terbinafine without sample pretreatment in biological fluid. The determination of terbinafine at the modified electrode with strongly accumulation was studied by differential pulse voltammetry (DPV). The peak current obtained at +1.156 V (vs. SCE) from DPV was linearly dependent on the terbinafine concentration in the range of 8.0 x 10(-8)-5.0 x 10(-5 )M in a B-R buffer solution (0.04 M, pH 1.81) with a correlation coefficient of 0.998. The detection limit (S/N=3) was 2.5 x 10(-8 )M. The low-cost modified electrode showed good sensitivity, selectivity, and stability. This developed method had been applied to the direct determination of terbinafine in human serum samples with satisfactory results. It is hopeful that the modified electrode will be applied for the medically clinical test and the pharmacokinetics in future.
Wang
Chengyin
C
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Mao
Yindao
Y
Wang
Deyan
D
Yang
Gongjun
G
Qu
Qishu
Q
Hu
Xiaoya
X
D001672:Biocompatible Materials / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D002138:Calibration; D003365:Costs and Cost Analysis; D003544:Cysteic Acid / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009281:Naphthalenes / Q000032:analysis*; D010084:Oxidation-Reduction; D044967:Serum / Q000737:chemistry; D000077291:Terbinafine
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D009281:Naphthalenes; D003544:Cysteic Acid; D000077291:Terbinafine; D003545:Cysteine