An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol.
A direct and stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol has been developed.
Giroux
Simon
S
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000378:metabolism; D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D013237:Stereoisomerism
D029742:Caenorhabditis elegans Proteins; D008024:Ligands; C528461:dafachronic acid A; D004875:Ergosterol