title: Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty.
abstract: Penetration of levofloxacin and moxifloxacin into cancellous and cortical bone was studied using high-performance liquid chromatography (HPLC) in 16 patients who underwent routine total hip arthroplasty. Our results demonstrate a good degree of penetration into bone for both quinolones. The mean cancellous penetration was 53.86% for moxifloxacin and 54.13% for levofloxacin. The penetration into cortical bone was 41.59% and 34.26% respectively. The concentrations for both quinolones were above the minimum inhibitory concentration (MIC(90s)) for the most common pathogens, so they can be used for the treatment of osteomyelitis.
authors.affiliation: 1st Internal Medicine Department, AHEPA University Hospital, Thessaloniki, Greece. simeon.metallidis@virgin.net
authors.forename: S
authors.initials: S
authors.lastname: Metallidis
authors.forename: D
authors.initials: D
authors.lastname: Topsis
authors.forename: J
authors.initials: J
authors.lastname: Nikolaidis
authors.forename: E
authors.initials: E
authors.lastname: Alexiadou
authors.forename: G
authors.initials: G
authors.lastname: Lazaraki
authors.forename: L
authors.initials: L
authors.lastname: Grovaris
authors.forename: A
authors.initials: A
authors.lastname: Theodoridou
authors.forename: P
authors.initials: P
authors.lastname: Nikolaidis
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D019644:Arthroplasty, Replacement, Hip; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001842:Bone and Bones / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007275:Injections, Intravenous; D064704:Levofloxacin; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000077266:Moxifloxacin; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010019:Osteomyelitis / Q000517:prevention & control; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D064704:Levofloxacin; D015242:Ofloxacin; D000077266:Moxifloxacin