Facultative endocrine progenitor cells in the adult pancreas.
Using a unique injury model of the pancreas in mouse, Xu et al. (2008) now reveal the involvement of neurogenin3, a marker for embryonic-type endocrine progenitor cells, in the formation of new insulin-producing beta cells. These neurogenin3-positive facultative endocrine progenitor cells in the adult pancreas may be of potential value for treating diabetes.
Dor
Yuval
Y
Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. yuvald@ekmd.huji.ac.il
Melton
Douglas A
DA
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers; D002454:Cell Differentiation; D049109:Cell Proliferation; D015870:Gene Expression; D005947:Glucose / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000378:metabolism; D008026:Ligation; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009924:Organ Culture Techniques; D010179:Pancreas / Q000166:cytology* / Q000293:injuries; D010183:Pancreatic Ducts / Q000601:surgery; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology*; D013997:Time Factors; D001616:beta-Galactosidase / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D015415:Biomarkers; D005947:Glucose; D049452:Green Fluorescent Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D001616:beta-Galactosidase; C407737:Neurog3 protein, mouse