C-reactive protein in relation to the development of microalbuminuria in type 1 diabetes: the Oxford Regional Prospective Study.
OBJECTIVE
To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA).


METHODS
hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes.


RESULTS
In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2-9.8] vs. 1.1 mg/l [0.2-6.4]; P = 0.02; adjusted P = 0.036).


CONCLUSIONS
In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.
Marcovecchio
M Loredana
ML
University Department of Paediatrics, Addenbrooke's Hospital, Cambridge, UK.
Giannini
Cosimo
C
Widmer
Barry
B
Dalton
R Neil
RN
Martinotti
Stefano
S
Chiarelli
Francesco
F
Dunger
David B
DB
D000293:Adolescent; D000419:Albuminuria / Q000097:blood / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D012016:Reference Values
D002097:C-Reactive Protein; D006442:Glycated Hemoglobin