title: C-reactive protein in relation to the development of microalbuminuria in type 1 diabetes: the Oxford Regional Prospective Study.
abstract: OBJECTIVE
  To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA).
  
  
  METHODS
  hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes.
  
  
  RESULTS
  In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2-9.8] vs. 1.1 mg/l [0.2-6.4]; P = 0.02; adjusted P = 0.036).
  
  
  CONCLUSIONS
  In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.
authors.affiliation: University Department of Paediatrics, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: M Loredana
authors.initials: ML
authors.lastname: Marcovecchio
authors.forename: Cosimo
authors.initials: C
authors.lastname: Giannini
authors.forename: Barry
authors.initials: B
authors.lastname: Widmer
authors.forename: R Neil
authors.initials: RN
authors.lastname: Dalton
authors.forename: Stefano
authors.initials: S
authors.lastname: Martinotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
authors.forename: David B
authors.initials: DB
authors.lastname: Dunger
mesh_terms: D000293:Adolescent; D000419:Albuminuria / Q000097:blood / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D012016:Reference Values
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin