title: Aurora B kinases restrict chromosome decondensation to telophase of mitosis.
abstract: The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome segregation. Vertebrates have three Aurora kinases, Aurora-A, -B and -C, while invertebrates have only Aurora-A and -B and yeasts have a single Aurora kinase, IpI1 in S. cerevisiae and Ark1 in S. pombe. Recently, the role of Aurora kinases in chromosome condensation has been defined; Aurora B plays a crucial role in the axial shortening of chromosomes during anaphase, presumably in order to prevent chromosome arms from becoming trapped within the cytokinetic plate.
authors.affiliation: Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
authors.forename: Amit Cj
authors.initials: AC
authors.lastname: Vas
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Clarke
mesh_terms: D000818:Animals; D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000502:physiology*; D002875:Chromosomes / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D008938:Mitosis / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D013692:Telophase / Q000235:genetics / Q000502:physiology*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C051886:chromosome decondensation factors; C576917:AURKA protein, human; C576921:AURKB protein, human; D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases