Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia.
To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients. While the distribution of individual alleles and genotypes did not differ between patients and controls, there were significant differences in the frequencies of some rare haplotypes and genotype combinations in the MDR1 gene between the two groups.
Semsei
Agnes F
AF
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Erdélyi
Dániel J
DJ
Ungvári
Ildikó
I
Kámory
Eniko
E
Csókay
Béla
B
Andrikovics
Hajnalka
H
Tordai
Attila
A
Cságoly
Edit
E
Falus
András
A
Kovács
Gábor T
GT
Szalai
Csaba
C
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012189:Retrospective Studies
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1