title: Thiosemicarbazones active against Clostridium difficile.
abstract: A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
authors.forename: Cait
authors.initials: C
authors.lastname: Costello
authors.forename: Tarja
authors.initials: T
authors.lastname: Karpanen
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lambert
authors.forename: Preena
authors.initials: P
authors.lastname: Mistry
authors.forename: Katy J
authors.initials: KJ
authors.lastname: Parker
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Rathbone
authors.forename: Jiangmeng
authors.initials: J
authors.lastname: Ren
authors.forename: Laura
authors.initials: L
authors.lastname: Wheeldon
authors.forename: Tony
authors.initials: T
authors.lastname: Worthington
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013882:Thiosemicarbazones