title: DNA replication timing data corroborate in silico human replication origin predictions.
abstract: We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication- from the transcription-associated compositional strand asymmetries observed in the human genome. Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of the putative replication origins that border the so-identified replication domains are replicated earlier than their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of this first experimental confirmation of these replication origin predictions that are likely to be early replicating and active in most tissues.
authors.affiliation: Laboratoire Joliot-Curie, ENS-Lyon, CNRS, France.
authors.forename: B
authors.initials: B
authors.lastname: Audit
authors.forename: S
authors.initials: S
authors.lastname: Nicolay
authors.forename: M
authors.initials: M
authors.lastname: Huvet
authors.forename: M
authors.initials: M
authors.lastname: Touchon
authors.forename: Y
authors.initials: Y
authors.lastname: d'Aubenton-Carafa
authors.forename: C
authors.initials: C
authors.lastname: Thermes
authors.forename: A
authors.initials: A
authors.lastname: Arneodo
mesh_terms: D000818:Animals; D004261:DNA Replication; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D010363:Pattern Recognition, Automated / Q000379:methods*