title: Natural history of cardiovascular disease in patients with diabetes: role of hyperglycemia.
abstract: Atherosclerotic vascular disease is more common in diabetic than in nondiabetic individuals. Diabetic macrovascular disease also has a more severe course with greater prevalence of multiple-vessel coronary artery disease and more diffuse elongated atheromas in affected blood vessels. In this review, we discuss possible reasons for increased incidence of cardiovascular (CV) events in individuals with diabetes. Although an increased prevalence of standard CV risk factors has been clearly documented in association with diabetes, diabetes-related abnormalities, particularly hyperglycemia, also play an important role. Epidemiological studies suggest that the effect of hyperglycemia on CV risk is independent of other known risk factors, but no data from primary interventional trials are available yet. Analysis of datasets from populations that included individuals with impaired glucose tolerance and impaired fasting glucose suggest that the pathogenic role of hyperglycemia on the blood vessel wall already exists in the early stages of glucose intolerance. The effect of postprandial or postchallenge hyperglycemia seems to be greater than the effect of fasting blood glucose abnormalities. The relationship of postprandial glycemia, fasting blood glucose, and CV risk in individuals with diagnosed (or overt) diabetes is less clear, although most reports indicate a greater pathogenic potential of postprandial hyperglycemia rather than fasting hyperglycemia. Based on the results of epidemiological reports, the most appropriate targets in interventional trials are postprandial hyperglycemia or A1C.
authors.affiliation: Eli Lilly Regional Operations, Vienna, Austria. milicevic_zvonko@lilly.com
authors.forename: Zvonko
authors.initials: Z
authors.lastname: Milicevic
authors.forename: Itamar
authors.initials: I
authors.lastname: Raz
authors.forename: Scott D
authors.initials: SD
authors.lastname: Beattie
authors.forename: Barbara N
authors.initials: BN
authors.lastname: Campaigne
authors.forename: Samiha
authors.initials: S
authors.lastname: Sarwat
authors.forename: Elwira
authors.initials: E
authors.lastname: Gromniak
authors.forename: Irina
authors.initials: I
authors.lastname: Kowalska
authors.forename: Edvard
authors.initials: E
authors.lastname: Galic
authors.forename: Meng
authors.initials: M
authors.lastname: Tan
authors.forename: Markolf
authors.initials: M
authors.lastname: Hanefeld
mesh_terms: D017677:Age Distribution; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000503:physiopathology*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D048909:Diabetes Complications / Q000503:physiopathology* / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000517:prevention & control; D012306:Risk; D012307:Risk Factors