Herbal and dietary supplement--drug interactions in patients with chronic illnesses.
Herbs, vitamins, and other dietary supplements may augment or antagonize the actions of prescription and nonprescription drugs. St. John's wort is the supplement that has the most documented interactions with drugs. As with many drug-drug interactions, the information for many dietary supplements is deficient and sometimes supported only by case reports. Deleterious effects are most pronounced with anticoagulants, cardiovascular medications, oral hypoglycemics, and antiretrovirals. Case reports have shown a reduction in International Normalized Ratio in patients taking St. John's wort and warfarin. Other studies have shown reduced levels of verapamil, statins, digoxin, and antiretrovirals in patients taking St. John's wort. Physicians should routinely ask patients about their use of dietary supplements when starting or stopping a prescription drug, or if unexpected reactions occur.
Gardiner
Paula
P
Osher Institute, Division for Research and Education in Complementary and Integrative Medical Therapies, USA. paula.gardiner@bmc.org
Phillips
Russell
R
Shaughnessy
Allen F
AF
D044966:Anti-Retroviral Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology; D002908:Chronic Disease; D019587:Dietary Supplements; D041743:Herb-Drug Interactions; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008517:Phytotherapy; D012307:Risk Factors
D044966:Anti-Retroviral Agents; D000925:Anticoagulants; D002317:Cardiovascular Agents; D007004:Hypoglycemic Agents