[Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy].
OBJECTIVE
To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.


METHODS
MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.


RESULTS
There was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).


CONCLUSIONS
The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu.
Wang
Xiaoli
X
Department of Obstetrics and Gynecology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, 610017 People's Republic of China.
Zhang
Li
L
Ou
Rong-qing
RQ
Wang
Jing
J
Liu
Shu-yun
SY
Chen
Qiang
Q
Su
Pin-can
PC
D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1