title: [Non Hodgkin's lymphoma and chronic hepatitis C virus infection: a non-fortuitous association. Two case reports].
abstract: Many authors suggest the role of hepatitis C virus (HCV) infection in the pathology of B-cell non Hodgkin's lymphomas; this is based on epidemiological, physiopathological and therapeutic arguments. The frequency of the association with hepatitis C virus infection is variable in the different study (1 to 30%). We report two cases of hepatitis C virus infection in association with non Hodgkin's lymphomas. The first case presented a low grad splenic and nodal non-Hodgkin's lymphoma associated with hepatitis C virus infection and complicated by hepato-cellular carcinoma. The second case presented a high grad nodal non-Hodgkin's lymphoma associated with HCV infection. Our cases report confirms the hypothesis of a key role of hepatitis C virus in the pathogenesis of B-cell lymphoproliferative disorders and in particular the non-Hodgkin's lymphoma. Although of several hypothesis concerning the ethiopathogenic mechanisms of this association, new studies will necessary to improve the real mechanism of this association
authors.affiliation: Service de gastroentérologie, Höpital Mohamed Taher Maamouri, Nabeul.
authors.forename: Sana
authors.initials: S
authors.lastname: Kallel
authors.forename: Mejda
authors.initials: M
authors.lastname: Essid
authors.forename: Salah
authors.initials: S
authors.lastname: Boujelbene
authors.forename: Ihsen
authors.initials: I
authors.lastname: Ben Brahim
authors.forename: Samia
authors.initials: S
authors.lastname: Chatty
authors.forename: Sadok
authors.initials: S
authors.lastname: Sassi
authors.forename: Moussadek
authors.initials: M
authors.lastname: Azzouz
mesh_terms: D000368:Aged; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged