Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction.
The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.
Ikuta
Kenjiro
K
Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Mori
Takeshi
T
Yamamoto
Tatsurhiro
T
Niidome
Takuro
T
Shimokawa
Hiroaki
H
Katayama
Yoshiki
Y
D000327:Adsorption; D000818:Animals; D001011:Aorta; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005070:Evans Blue; D008823:Micelles; D053758:Nanoparticles; D011108:Polymers; D013552:Swine
D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D005070:Evans Blue; D004317:Doxorubicin