New insights on poly(vinyl acetate)-based coated floating tablets: characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength.
The purpose of this study was to investigate the mechanism of floating and drug release behaviour of poly(vinyl acetate)-based floating tablets with membrane controlled drug delivery. Propranolol HCl containing tablets with Kollidon SR as an excipient for direct compression and different Kollicoat SR 30 D/Kollicoat IR coats varying from 10 to 20mg polymer/cm2 were investigated regarding drug release in 0.1N HCl. Furthermore, the onset of floating, the floating duration and the floating strength of the device were determined. In addition, benchtop MRI studies of selected samples were performed. Coated tablets with 10mg polymer/cm2 SR/IR, 8.5:1.5 coat exhibited the shortest lag times prior to drug release and floating onset, the fastest increase in and highest maximum values of floating strength. The drug release was delayed efficiently within a time interval of 24 h by showing linear drug release characteristics. Poly(vinyl acetate) proved to be an appropriate excipient to ensure safe and reliable drug release. Floating strength measurements offered the possibility to quantify the floating ability of the developed systems and thus to compare different formulations more efficiently. Benchtop MRI studies allowed a deeper insight into drug release and floating mechanisms noninvasively and continuously.
Strübing
Sandra
S
Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Abboud
Tâmara
T
Contri
Renata Vidor
RV
Metz
Hendrik
H
Mäder
Karsten
K
D002245:Carbon Dioxide / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D018565:Food-Drug Interactions; D008279:Magnetic Resonance Imaging; D011145:Polyvinyls / Q000737:chemistry*; D011433:Propranolol / Q000008:administration & dosage / Q000737:chemistry; D013270:Stomach; D013607:Tablets; D014783:Viscosity; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D005079:Excipients; D011145:Polyvinyls; D013607:Tablets; D014867:Water; D002245:Carbon Dioxide; C013215:polyvinyl acetate; D011433:Propranolol