title: [Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy].
abstract: OBJECTIVE
  To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.
  
  
  METHODS
  MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.
  
  
  RESULTS
  There was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).
  
  
  CONCLUSIONS
  The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu.
authors.affiliation: Department of Obstetrics and Gynecology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, 610017 People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Rong-qing
authors.initials: RQ
authors.lastname: Ou
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shu-yun
authors.initials: SY
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Pin-can
authors.initials: PC
authors.lastname: Su
mesh_terms: D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*
chemical_list: D019363:Cytochrome P-450 CYP1A1