title: Factors determining early left atrial reverse remodeling after mitral valve surgery.
abstract: This study aimed to investigate the factors determining early left atrial (LA) reverse remodeling after mitral valve (MV) surgery. The left atrium is frequently dilated in patients with mitral stenosis (MS) or mitral regurgitation (MR). MV surgery usually results in LA volume reduction. However, the factors associated with LA reverse remodeling after MV surgery are not clearly defined. One hundred thirty-eight patients (51 men, 87 women; mean age, 53 years) underwent transthoracic echocardiography before and after MV surgery. Maximal LA volume was measured using the prolate ellipsoid model. The percentage of LA volume change was calculated. The patients were grouped according to age (<50 vs >or=50 years), predominant lesion (pure MR vs some degree of MS), type of surgery (MV repair vs MV replacement), and preoperative rhythm (sinus rhythm vs atrial fibrillation). LA volume decreased from 147+/-93 to 103+/-43 ml (p<0.001) after surgery. LA reverse remodeling was more prominent in patients who were <50 years old (percentage of LA volume change -31.2+/-17.4 vs -18.4+/-19.2, p<0.001), had pure MR (percentage of LA volume change -30.4+/-18.6 vs -17.3+/-18.2, p<0.001), and had a preoperative sinus rhythm (percentage of LA volume change -28.5+/-17.7 vs -20.5+/-20.0, p=0.019). In conclusion, on stepwise multiple regression analysis, preoperative LA volume, predominant lesion, age, and cardiac rhythm were significant predictors of LA reverse remodeling. A larger preoperative LA volume, MR rather than MS, younger age at the time of surgery, and sinus rhythm were important predictors of LA reverse remodeling after MV surgery.
authors.affiliation: Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Deok-Kyu
authors.initials: DK
authors.lastname: Cho
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Ha
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Chang
authors.forename: Se-Hwa
authors.initials: SH
authors.lastname: Lee
authors.forename: Se-Jung
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Shim
authors.forename: Jung Rae
authors.initials: JR
authors.lastname: Cho
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Eui-Young
authors.initials: EY
authors.lastname: Choi
authors.forename: Se-Joong
authors.initials: SJ
authors.lastname: Rim
authors.forename: Namsik
authors.initials: N
authors.lastname: Chung
mesh_terms: D000328:Adult; D000367:Age Factors; D002306:Cardiac Volume; D004108:Dilatation, Pathologic; D005260:Female; D006325:Heart Atria / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D008946:Mitral Valve Stenosis / Q000601:surgery*; D015999:Multivariate Analysis; D011184:Postoperative Period