title: Interpersonal responses among sibling dyads tested for BRCA1/BRCA2 gene mutations.
abstract: OBJECTIVE
  The familial context plays an important role in psychosocial responses to genetic testing. The purpose of this study was to compare sibling pairs with different combinations of BRCA1/BRCA2 test results on measures of affect, interpersonal responses, and physiological reactions.
  
  
  METHODS
  Forty-nine sibling dyads with different combinations of BRCA1/BRCA2 test results (i.e., mixed, positive, negative) completed a questionnaire, and 35 of the dyads also participated in a laboratory-based discussion of genetic testing.
  
  
  METHODS
  The primary outcome variables included participant reports of supportive actions toward their sibling, state anger and anxiety, perceptions of sibling behavior, and electrodermal responses.
  
  
  RESULTS
  Compared to positive and negative dyads, mixed pairs reported less friendly general support actions, noted more anger, and perceived their sibling to be less friendly and more dominant during the interactions. In comparisons between same-result (i.e., positive, negative) pairs, positive dyads reported more dominant support behaviors and perceived their sibling to be friendlier during the interactions.
  
  
  CONCLUSIONS
  Data suggest that siblings who have different test results may experience more interpersonal strain than siblings who have the same test result. Future research on genetic testing and family relationships can expand upon these findings.
authors.affiliation: Department of Psychology, Washington State University, Pullman 99164-4820, USA. hamann@wsu.edu
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Hamann
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Smith
authors.forename: Ken R
authors.initials: KR
authors.lastname: Smith
authors.forename: Robert T
authors.initials: RT
authors.lastname: Croyle
authors.forename: John M
authors.initials: JM
authors.lastname: Ruiz
authors.forename: John C
authors.initials: JC
authors.lastname: Kircher
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Botkin
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics / Q000523:psychology; D011110:Polymorphism, Genetic / Q000235:genetics*; D035781:Siblings / Q000523:psychology*; D013315:Stress, Psychological; D011795:Surveys and Questionnaires