Self-phase modulation signatures of neuronal activity.
We use phase-sensitive detection of spectral hole refilling to demonstrate strong novel intrinsic nonlinear signatures of neuronal activation in hippocampal brain slices. The ability to gain access to this fundamentally new intrinsic contrast with modest power levels suggests a new approach to in vivo neural imaging. We expect that we can extrapolate our method to high spatial and temporal resolution in deep tissue while retaining the noninvasive character.
Fischer
Martin C
MC
Department of Chemistry, Duke University, Durham, NC 27708, USA. martin.fischer@duke.edu
Liu
Henry C
HC
Piletic
Ivan R
IR
Escobedo-Lozoya
Yasmin
Y
Yasuda
Ryohei
R
Warren
Warren S
WS
D000818:Animals; D001921:Brain / Q000473:pathology; D002138:Calibration; D003952:Diagnostic Imaging; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007834:Lasers; D008954:Models, Biological; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D055095:Optics and Photonics; D051381:Rats; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D018698:Glutamic Acid