Penicillenols from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum.
Six new tetramic acids derivatives, penicillenols A(1), A(2), B(1), B(2), C(1), and C(2) (1-6), together with citrinin, phenol A acid, phenol A, and dihydrocitrinin, were identified from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Their structures were elucidated on the basis of comprehensive spectral analysis. All the new compounds were evaluated for their cytotoxic effects on four cell lines by the MTT method. Penicillenols A(1) and B(1) showed cytotoxicities against HL-60 cell line with IC(50) values of 0.76 microM and 3.20 microM, respectively.
Lin
Zhen-Jian
ZJ
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Lu
Zhen-Yu
ZY
Zhu
Tian-Jiao
TJ
Fang
Yu-Chun
YC
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry*; D029623:Primulaceae / Q000382:microbiology*; D011760:Pyrrolidinones / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
D000935:Antifungal Agents; D011760:Pyrrolidinones; D013778:Tetrazolium Salts; D013844:Thiazoles; C009435:tetramic acid; C022616:thiazolyl blue