Role of mitochondria in drug-induced cholestatic injury.
Mitochondria have multiple functions in eukaryotic cells and are organized into dynamic tubular networks that continuously undergo changes through coordinated fusion and fission and migration through the cytosol. Mitochondria integrate cell-signaling networks, especially those involving the intracellular messenger Ca(2+), into the regulation of metabolic pathways. Recently, it has become clear that mitochondria are central to the three main cell death pathways, namely necrosis, apoptosis, and autophagic cell death. This article discusses the role of mitochondria in drug-induced cholestatic injury to the liver. The role of mitochondria in the cellular adaptation against the toxic effects of bile acids is discussed also.
Kass
George E N
GE
Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. g.kass@surrey.ac.uk
Price
Shirley C
SC
D000818:Animals; D016923:Cell Death / Q000502:physiology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*