title: Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides.
abstract: A series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities.
authors.affiliation: Drug Discovery Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, South Korea.
authors.forename: Tae-Souk
authors.initials: TS
authors.lastname: Kang
authors.forename: Hyang-Ok
authors.initials: HO
authors.lastname: Jo
authors.forename: Woo-Kyu
authors.initials: WK
authors.lastname: Park
authors.forename: Jong-Pyung
authors.initials: JP
authors.lastname: Kim
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Konishi
authors.forename: Jae-Yang
authors.initials: JY
authors.lastname: Kong
authors.forename: No-Sang
authors.initials: NS
authors.lastname: Park
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Jung
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D002934:Cinnamates