title: Experiments confirm the influence of genome long-range correlations on nucleosome positioning.
abstract: From the statistical analysis of nucleosome positioning data for chromosome III of S. cerevisiae, we demonstrate that long-range correlations (LRC) in the genomic sequence strongly influence the organization of nucleosomes. We present a physical explanation of how LRC may significantly condition the overall formation and positioning of nucleosomes including the nucleosome-free regions observed at gene promoters. From grand canonical Monte Carlo simulations based upon a simple sequence-dependent nucleosome model, we show that LRC induce a patchy nucleosome occupancy landscape with alternation of "crystal-like" phases of confined regularly spaced nucleosomes and "fluidlike" phases of rather diluted nonpositioned nucleosomes.
authors.affiliation: Laboratoire Joliot-Curie and Laboratoire de Physique, CNRS, ENS-Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: C
authors.initials: C
authors.lastname: Vaillant
authors.forename: B
authors.initials: B
authors.lastname: Audit
authors.forename: A
authors.initials: A
authors.lastname: Arneodo
mesh_terms: D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics*; D016681:Genome, Fungal; D008957:Models, Genetic; D009010:Monte Carlo Method; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004271:DNA, Fungal; D009707:Nucleosomes