title: Penicillenols from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum.
abstract: Six new tetramic acids derivatives, penicillenols A(1), A(2), B(1), B(2), C(1), and C(2) (1-6), together with citrinin, phenol A acid, phenol A, and dihydrocitrinin, were identified from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Their structures were elucidated on the basis of comprehensive spectral analysis. All the new compounds were evaluated for their cytotoxic effects on four cell lines by the MTT method. Penicillenols A(1) and B(1) showed cytotoxicities against HL-60 cell line with IC(50) values of 0.76 microM and 3.20 microM, respectively.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
authors.forename: Zhen-Jian
authors.initials: ZJ
authors.lastname: Lin
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Lu
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhu
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry*; D029623:Primulaceae / Q000382:microbiology*; D011760:Pyrrolidinones / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000935:Antifungal Agents; D011760:Pyrrolidinones; D013778:Tetrazolium Salts; D013844:Thiazoles; C009435:tetramic acid; C022616:thiazolyl blue