[Role of fluorescence diagnosis using Photosens in patients with subretinal neovascular membrane].
The paper shows the capacity of fluorescence diagnosis (FD) in patients with subretinal neovascular membranes. Photosens was used as a photosensitizer (PS) (NIOPIK) in FD. The agent was intravenously injected in a dose of 0.05 mg/kg. To study the kinetics of tissue PS distribution, the authors employed a procedure of local fluorescence spectroscopy using a LESA-01-Biospek spectrometer, which was improved when applying the procedure for visual assessment of a visual fluorescence image. It was ascertained that the results of photodynamic therapy (PDT) should be compulsorily taken into account in processing its parameters. In some cases, PDT may be recommended on days 3, 5, and 7 after administration of an agent. By taking into account the pharmacodynamics of Photosens, 0.5 mg/kg, all patients should keep the light regime for 3 months.
Budzinskaia
M V
MV
Shevchik
S A
SA
Kiseleva
T N
TN
Loshchenov
V B
VB
Gurova
I V
IV
Shchegoleva
I V
IV
Kuz'min
S G
SG
Vorozhtsov
G N
GN
D003937:Diagnosis, Differential; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D015861:Retinal Neovascularization / Q000378:metabolism / Q000473:pathology*; D013050:Spectrometry, Fluorescence / Q000379:methods
D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C048577:aluminum tetrasulfophthalocyanine