Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major.
We measured left atrial size and function from biplane MRI data in 62 adults with thalassemia major. Age-adjusted left atrial ejection fraction was depressed in 7 out of 20 subjects having T2* < 10 ms. Left atrial size, left ventricular size and cardiac output fell with cardiac iron loading, representing increased cardiac or peripheral vascular stiffness.
Li
Walter
W
Coates
Thomas
T
Wood
John C
JC
D000293:Adolescent; D000328:Adult; D016279:Atrial Function, Left; D015415:Biomarkers; D002302:Cardiac Output; D054715:Cardiotoxins / Q000378:metabolism*; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006331:Heart Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D017086:beta-Thalassemia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*
D015415:Biomarkers; D054715:Cardiotoxins; D007501:Iron