Conjunctival involvement in chronic recurrent multifocal osteomyelitis.
OBJECTIVE
To report a case of chronic recurrent multifocal osteomyelitis (CRMO) with conjunctival involvement.


METHODS
Retrospective chart review.


RESULTS
A 10-year-old girl who complained of fatigue and debilitating pain in both hips and legs for >1 year had recurrent episodes of redness and discharge in both eyes with little response to different topical medications. The diagnosis of CRMO was confirmed with the help of magnetic resonance imaging, bone scan, and bone biopsy results. She had moderate hyperemia and multiple discrete salmon-colored lesions in both palpebral and fornical conjunctivae. Biopsy revealed chronic inflammatory infiltration composed predominantly of lymphocytes forming a follicular pattern. Conjunctival lesions worsened during relapses of skeletal symptoms, improved during remission, and resolved shortly after the initiation of oral prednisolone therapy. No recurrence was observed during 16 months of follow-up.


CONCLUSIONS
Salmon-colored conjunctival lesions may accompany CRMO and respond favorably to systemic steroid therapy.
Ozbek
Zeynep
Z
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey. zeynep_ozbek@hotmail.com
Makay
Balahan
B
Unsal
Erbil
E
Durak
Ismet
I
Gunes
Dilek
D
Anal
Ozden
O
Ozer
Erdener
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D003229:Conjunctival Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D012460:Sulfasalazine / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D012460:Sulfasalazine; D011239:Prednisolone; D008727:Methotrexate