title: Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.
abstract: Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
authors.affiliation: Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Zhou
authors.forename: Jaeki
authors.initials: J
authors.lastname: Min
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
authors.forename: Anne
authors.initials: A
authors.lastname: Young
authors.forename: Heather
authors.initials: H
authors.lastname: Deshazer
authors.forename: Tian
authors.initials: T
authors.lastname: Gao
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Neville R
authors.initials: NR
authors.lastname: Kallenbach
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014227:Triazines