title: DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer.
abstract: Oral health care professionals could drastically improve the quality of life for patients with potentially malignant oral lesions by using a noninvasive test that could be used to detect cancer using saliva. Promoter DNA hypermethylation is a critical step in oral carcinogenesis and has a number of significant advantages over genetic and protein diagnostic markers. Methylight is a recently developed assay that rapidly quantifies promoter hypermethylation and could potentially be applied into a clinical setting.
authors.affiliation: University of California, San Francisco, School of Dentistry, USA. chi.viet@ucsf.edu
authors.forename: C T
authors.initials: CT
authors.lastname: Viet
authors.forename: Richard C K
authors.initials: RC
authors.lastname: Jordan
authors.forename: Brian L
authors.initials: BL
authors.lastname: Schmidt
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000235:genetics; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D042241:Early Diagnosis; D017491:Genes, APC; D019942:Genes, p16; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D047428:Protein Kinase Inhibitors; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes