[Genomic approaches to bone and joint diseases. The changes of gene expressions in bone marrow cells after skeletal unloading and reloading].
Generations of nitric oxide through inducible nitric oxide synthase and prostaglandins through cyclooxygenase-2 are necessary for stimulation of bone formation upon skeletal reloading. Disruption of the p53 gene results in preserved bone mass and bone formation after skeletal unloading. Chronic skeletal loading promotes osteoblastic differentiation and suppresses adipogenic differentiation in association with facilitation of the signal through parathyroid hormone receptor.
Sakai
Akinori
A
University of Occupational and Environmental Health, School of Medicine, Department of Orthopaedic Surgery.
D001854:Bone Marrow Cells / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D015870:Gene Expression; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D015398:Signal Transduction; D013314:Stress, Mechanical