title: Full-mouth disinfection for the treatment of adult chronic periodontitis.
abstract: BACKGROUND
  In an attempt to enhance treatment outcomes, alternative protocols for anti-infective periodontal therapy have been introduced.
  
  
  OBJECTIVE
  To evaluate the effectiveness of full-mouth disinfection or full-mouth scaling compared to conventional quadrant scaling for periodontitis.
  
  
  METHODS
  Data sources included electronic databases, handsearched journals and contact with experts. The Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched. Reference lists from relevant articles were scanned and the authors of eligible studies were contacted to identify trials and obtain additional information. Date of most recent searches: December 2006: (CENTRAL) (The Cochrane Library 2006, Issue 4).
  
  
  METHODS
  Randomised controlled trials were selected with at least 3 months follow up comparing full-mouth scaling and root planing within 24 hours with (FMD) or without (FMS) the adjunctive use of an antiseptic (chlorhexidine) with conventional quadrant scaling and root planing (control). The methodological quality of the studies was assessed within the data extraction form, mainly focusing on: method of randomisation, allocation concealment, blindness of examiners and completeness of follow up.
  
  
  METHODS
  Data extraction and quality assessment were conducted independently by multiple review authors. The primary outcome measure was tooth loss, secondary outcomes were reduction of probing depth, bleeding on probing and gain in probing attachment. The Cochrane Collaboration statistical guidelines were followed.
  
  
  RESULTS
  The search identified 216 abstracts. Review of these abstracts resulted in 12 publications for detailed review. Finally, seven randomised controlled trials (RCTs) which met the criteria for eligibility were independently selected by two review authors. None of the studies included reported on tooth loss. All treatment modalities led to significant improvements in clinical parameters after a follow up of at least 3 months. For the secondary outcome, reduction in probing depth, the mean difference between FMD and control was 0.53 mm (95% confidence interval (CI) 0.28 to 0.77) in moderately deep pockets of single rooted teeth and for gain in probing attachment 0.33 mm (95% CI 0.04 to 0.62) in moderately deep single and multirooted teeth. Comparing FMD and FMS the mean difference in one study for gain in probing attachment amounted to 0.74 mm in favour of FMS (95% CI 0.17 to 1.31) for deep pockets in multirooted teeth, while another study reported a mean difference for reduction in bleeding on probing of 18% in favour of FMD (95% CI -33.74 to -2.26) for deep pockets of single rooted teeth. No significant differences were observed for any of the outcome measures, when comparing FMS and control.
  
  
  CONCLUSIONS
  In patients with chronic periodontitis in moderately deep pockets slightly more favourable outcomes for pocket reduction and gain in probing attachment were found following FMD compared to control. However, these additional improvements were only modest and there was only a very limited number of studies available for comparison, thus limiting general conclusions about the clinical benefit of full-mouth disinfection.
authors.affiliation: University Kiel, Department of Operative Dentistry and Periodontology, Arnold-Heller-Str. 16, Kiel, Germany, 24105. eberhard@konspar.uni-kiel.de
authors.forename: J
authors.initials: J
authors.lastname: Eberhard
authors.forename: S
authors.initials: S
authors.lastname: Jepsen
authors.forename: P-M
authors.initials: PM
authors.lastname: Jervøe-Storm
authors.forename: I
authors.initials: I
authors.lastname: Needleman
authors.forename: H V
authors.initials: HV
authors.lastname: Worthington
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D002908:Chronic Disease; D012534:Dental Scaling / Q000379:methods*; D004203:Disinfection / Q000379:methods; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D016745:Root Planing / Q000379:methods*; D016388:Tooth Loss / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine