title: Influence of morphology on survival for non-Hodgkin lymphoma in Europe and the United States.
abstract: We explored the influence of morphology on geographic differences in 5-year survival for non-Hodgkin lymphoma (NHL) diagnosed in 1990-1994 and followed for 5years: 16,955 cases from 27 EUROCARE-3 cancer registries, and 22,713 cases from 9 US SEER registries. Overall 5-year relative survival was 56.1% in EUROCARE west, 47.1% in EUROCARE east and 56.3% in SEER. Relative excess risk (RER) of death was 1.05 (95% confidence interval (CI) 1.01-1.10) in EUROCARE west, 1.52 (95% CI 1.44-1.60) in EUROCARE east (SEER reference). Excess risk of death was significantly above reference (diffuse B lymphoma) for Burkitt's and NOS lymphoma; not different for lymphoblastic and other T-cell; significantly below reference (in the order of decreasing relative excess risk) for NHL NOS, mantle cell/centrocytic, lymphoplasmacytic, follicular, small lymphocytic/chronic lymphocytic leukaemia, other specified NHL and cutaneous morphologies. Interpretation of marked variation in survival with morphology is complicated by classification inconsistencies. The completeness and standardisation of cancer registry morphology data needs to be improved.
authors.affiliation: Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, I-20133, Milan, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Sant
authors.forename: Claudia
authors.initials: C
authors.lastname: Allemani
authors.forename: Roberta
authors.initials: R
authors.lastname: De Angelis
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjosè
authors.forename: Alessandro M
authors.initials: AM
authors.lastname: Gianni
authors.forename: Pilar
authors.initials: P
authors.lastname: Giraldo
authors.forename: Francesca
authors.initials: F
authors.lastname: Marchesi
authors.forename: Rafael
authors.initials: R
authors.lastname: Marcos-Gragera
authors.forename: Carmen
authors.initials: C
authors.lastname: Martos-Jiménez
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadié
authors.forename: Martine
authors.initials: M
authors.lastname: Raphael
authors.forename: Franco
authors.initials: F
authors.lastname: Berrino
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005060:Europe; D005240:Feasibility Studies; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000401:mortality* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012042:Registries / Q000592:standards*; D014481:United States