Oxidative stress and liver disease.
Pro-oxidants are numerous and varied. Antioxidants are equally varied in their mechanism of action, and oxidative stress is likely not a simple arithmetic summation of these two opposing forces. More likely, it is a complex set of interrelated formulas with large areas of overlap and small areas of unique effect. In this article, the language of oxidative stress is reviewed, the consequences of oxidative stress are presented, the pathophysiology of oxidative stress in the liver is briefly discussed, and various antioxidant treatment options most relevant to small animal patients with liver disease are reviewed.
Webb
Craig
C
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1678, USA. cbwebb@colostate.edu
Twedt
David
D
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants; D017382:Reactive Oxygen Species; D009569:Nitric Oxide