title: Estimating absorbed dose of pesticides in a field setting using biomonitoring data and pharmacokinetic models.
abstract: Linking biomarker data to pharmacokinetic (PK) models permits comparison of absorbed dose with a toxicological benchmark, which is an important step to understanding the health implications of pesticide exposure. The purpose of this analysis was to evaluate the feasibility of reconstructing the absorbed dose of two pesticides using PK models developed from biomarker data in a study of occupational application of these compounds. Twenty-four-hour urine samples were collected from farmers 24 h before through 96 h after a typical application of chlorpyrifos or 2,4-D. PK models were used to link the amounts found in urine samples to absorbed dose. Modeled total body dose estimates (in micrograms) were compared to measured dose from time 0-96 h. Despite the complexities surrounding the interpretation of biomonitoring data from a field setting, the models developed as part of this analysis accurately estimated the absorbed dose of 2,4-D and chlorpyrifos when collection of urine samples was largely complete. Over half of the farmers were excluded from modeling due to suspected noncompliance with urine collection or confounding exposure events, which highlights the importance of these issues for designing and interpreting biomonitoring data in future studies. Further evaluation of PK models in scenarios using single void samples is warranted for improving field-based dose assessments.
authors.affiliation: Division of Environmental Health Science, School of Public Health, Minneapolis, Minnesota, USA.
authors.forename: Deanna P
authors.initials: DP
authors.lastname: Scher
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Sawchuk
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Alexander
authors.forename: John L
authors.initials: JL
authors.lastname: Adgate
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000493:pharmacokinetics* / Q000652:urine; D000383:Agriculture; D015415:Biomarkers; D004390:Chlorpyrifos / Q000493:pharmacokinetics* / Q000652:urine; D005240:Feasibility Studies; D006540:Herbicides / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics* / Q000652:urine; D008954:Models, Biological; D016273:Occupational Exposure
chemical_list: D015415:Biomarkers; D006540:Herbicides; D007306:Insecticides; D015084:2,4-Dichlorophenoxyacetic Acid; D004390:Chlorpyrifos