title: A variant transcript, e1a3, of the minor BCR-ABL fusion gene in acute lymphoblastic leukemia: case report and review of the literature.
abstract: We report a rare case of adult Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) with an e1a3 fusion transcript. A 25-year-old female consulted our hospital for leukocytosis and thrombocytopenia. She was diagnosed with Ph-positive precursor B cell ALL. The patient's BCR-ABL fusion gene showed the e1a3 transcript. She received bone marrow transplantation (BMT) in the first complete remission (CR). However, the disease relapsed 4 months later, and she received a second BMT in the second CR, which caused lethal venoocculusive disease. The duration of the total clinical course was 18 months. We established a new cell line from the patient's leukemic cells at the time of relapse, which is very rare and useful for study as an atypical Ph-positive ALL model. The literature on Ph-positive leukemia lacking ABL exon 2 was also reviewed.
authors.affiliation: Department of Hematology, Hamamatsu Medical Center, Tomitsuka-cho 328, Naka-ku, Hamamatsu, 432-8580, Japan. shinfuji@hmedc.or.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Fujisawa
authors.affiliation: Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Satoki
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Hematology, Hamamatsu Medical Center, Tomitsuka-cho 328, Naka-ku, Hamamatsu, 432-8580, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Naito
authors.affiliation: Department of Hematology, Hamamatsu Medical Center, Tomitsuka-cho 328, Naka-ku, Hamamatsu, 432-8580, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Cancer Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ohnishi
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005091:Exons / Q000235:genetics; D005260:Female; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics