Effect of Citrocard on functional activity of cardiomyocyte mitochondria during chronic alcohol intoxication.
Chronic administration of 50% ethanol in a dose of 8 g/kg produces a toxic effect on functional activity of cardiomyocyte mitochondria, which manifested in decreased rates of respiration and oxidative phosphorylation. Structural GABA analogue Citrocard (phenibut citrate) and reference preparation piracetam in doses of 50 and 200 mg/kg, respectively, prevented the damaging effect of alcohol, which was seen from increased indexes of oxidative phosphorylation in treated animals compared to the control group.
Perfilova
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VN
Department of Pharmacology and Biopharmacy, Faculty of Postgraduate Medical Training, Institute of Pharmacology, Volgograd State Medical University.
Ostrovskii
O V
OV
Verovskii
V E
VE
Popova
T A
TA
Lebedeva
S A
SA
Dib
H
H
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D018682:GABA Agents / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam