title: The Plasmodium export element revisited.
abstract: We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.
authors.affiliation: Johann Wolfgang Goethe-University, Institute of Cell Biology and Neuroscience, Centre for Membrane Proteomics, Frankfurt am Main, Germany. hiss@bioinformatik.uni-frankfurt.de
authors.forename: Jan Alexander
authors.initials: JA
authors.lastname: Hiss
authors.forename: Jude Marek
authors.initials: JM
authors.lastname: Przyborski
authors.forename: Florian
authors.initials: F
authors.lastname: Schwarte
authors.forename: Klaus
authors.initials: K
authors.lastname: Lingelbach
authors.forename: Gisbert
authors.initials: G
authors.lastname: Schneider
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D019295:Computational Biology; D057927:Hydrophobic and Hydrophilic Interactions; D010963:Plasmodium falciparum / Q000737:chemistry*; D021382:Protein Sorting Signals; D020543:Proteome; D015800:Protozoan Proteins / Q000737:chemistry*
chemical_list: D021382:Protein Sorting Signals; D020543:Proteome; D015800:Protozoan Proteins