title: Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair.
  
  
  METHODS
  Ten pigs were included in this study. The abdomens of the animals were opened by means of a median subumbilical laparotomy to place four prostheses that were cut into square pieces of 4 x 4 cm. The two prostheses in the most cephalic position were polypropylene meshes, and the other two prostheses in a more caudal position were expanded polytetrafluoroethylene prostheses (Dualmesh Plus Corduroy). The prostheses on the right side of each animal were previously impregnated with fibrin glue. After 5 weeks, the animals were reoperated on to assess the quantity and quality (consistency) of the adhesions.
  
  
  RESULTS
  There were fewer intraperitoneal adhesions and they were more labile in the case of prostheses impregnated with fibrin glue. Moreover, we also observed that in many of the animals the polypropylene mesh did not show any adhesions, although polypropylene has been considered to be a typical adhesion producing material.
  
  
  CONCLUSIONS
  Fibrin glue reduces both the quantity and consistency of adhesions, even in the case of polypropylene meshes.
authors.affiliation: Surgical Department, Laparoscopic Surgery Unit, "Virgen del Rocío" University Hospital, c/ Baños 76, 41002, Seville, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Martín-Cartes
authors.forename: Salvador
authors.initials: S
authors.lastname: Morales-Conde
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Suárez-Grau
authors.forename: Manuel
authors.initials: M
authors.lastname: Bustos-Jiménez
authors.forename: Jean-Marie Hisnard
authors.initials: JM
authors.lastname: Cadet-Dussort
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Bernal
authors.forename: Juan
authors.initials: J
authors.lastname: Morcillo-Azcárate
authors.forename: Juan David
authors.initials: JD
authors.lastname: Tutosaus-Gómez
authors.forename: Salvador
authors.initials: S
authors.lastname: Morales-Méndez
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006555:Hernia, Ventral / Q000601:surgery*; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D019736:Prostheses and Implants / Q000009:adverse effects; D013526:Surgical Mesh / Q000009:adverse effects; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D013552:Swine; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives