title: Self-phase modulation signatures of neuronal activity.
abstract: We use phase-sensitive detection of spectral hole refilling to demonstrate strong novel intrinsic nonlinear signatures of neuronal activation in hippocampal brain slices. The ability to gain access to this fundamentally new intrinsic contrast with modest power levels suggests a new approach to in vivo neural imaging. We expect that we can extrapolate our method to high spatial and temporal resolution in deep tissue while retaining the noninvasive character.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA. martin.fischer@duke.edu
authors.forename: Martin C
authors.initials: MC
authors.lastname: Fischer
authors.forename: Henry C
authors.initials: HC
authors.lastname: Liu
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Piletic
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Escobedo-Lozoya
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yasuda
authors.forename: Warren S
authors.initials: WS
authors.lastname: Warren
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002138:Calibration; D003952:Diagnostic Imaging; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007834:Lasers; D008954:Models, Biological; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D055095:Optics and Photonics; D051381:Rats; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
chemical_list: D018698:Glutamic Acid