title: Magnetic force microscopy of superparamagnetic nanoparticles.
abstract: The use of magnetic force microscopy (MFM) to detect probe-sample interactions from superparamagnetic nanoparticles in vitro in ambient atmospheric conditions is reported here. By using both magnetic and nonmagnetic probes in dynamic lift-mode imaging and by controlling the direction and magnitude of the external magnetic field applied to the samples, it is possible to detect and identify the presence of superparamagnetic nanoparticles. The experimental results shown here are in agreement with the estimated sensitivity of the MFM technique. The potential and challenges for localizing nanoscale magnetic domains in biological samples is discussed.
authors.affiliation: Biomedical Engineering Department, Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Schreiber
authors.forename: Mayur
authors.initials: M
authors.lastname: Savla
authors.forename: Denis V
authors.initials: DV
authors.lastname: Pelekhov
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Iscru
authors.forename: Camelia
authors.initials: C
authors.lastname: Selcu
authors.forename: P Chris
authors.initials: PC
authors.lastname: Hammel
authors.forename: Gunjan
authors.initials: G
authors.lastname: Agarwal
mesh_terms: D052203:Ferrosoferric Oxide / Q000737:chemistry; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force / Q000379:methods* / Q000706:statistics & numerical data; D010316:Particle Size
chemical_list: D052203:Ferrosoferric Oxide