New neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines I-L (1-4), were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were established on the basis of detailed spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC(50) values in the range 3.2-8.3 microM.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, Yantai, People's Republic of China. daishengjun_9@hotmail.com
Liang
Dong-Dong
DD
Ren
Yan
Y
Liu
Ke
K
Shen
Li
L
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008751:Methylene Blue; D010936:Plant Extracts / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D010936:Plant Extracts; D008751:Methylene Blue