Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.
BACKGROUND
The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.


OBJECTIVE
Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.


METHODS
This is a clinical case report from the Clinical Research Center of the National Institutes of Health.


METHODS
One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.


RESULTS
The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.


CONCLUSIONS
A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
Lodish
Maya B
MB
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
Powell
Anathea C
AC
Abu-Asab
Mones
M
Cochran
Craig
C
Lenz
Petra
P
Libutti
Steven K
SK
Pingpank
James F
JF
Tsokos
Maria
M
Gorden
Phillip
P
D000293:Adolescent; D005260:Female; D015408:Gastrinoma / Q000209:etiology*; D005755:Gastrins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000209:etiology*; D018358:Neuroendocrine Tumors / Q000378:metabolism* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000378:metabolism*; D013577:Syndrome
D005755:Gastrins; D007328:Insulin