title: Anoxic preconditioning: a way to enhance the cardioprotection of mesenchymal stem cells.
abstract: OBJECTIVE
  We hypothesized that anoxic preconditioning (AP) could enhance the cardioprotective effect of mesenchymal stem cells (MSCs).
  
  
  METHODS
  Myocardial infarction (MI) was set up in Sprague-Dawley rats and left ventricles were randomly injected with the following: DMEM, MSCs and AP-MSCs. Cardiac function was assessed by echocardiography 4 weeks after transplantation, hematoxylin-eosin staining and Masson trichrome were performed subsequently.
  
  
  RESULTS
  Increased fractional shortening, ejection fraction and decreased infarct size were observed most obviously in AP-MSCs group, accompanied by increased arteriole density and cell survival.
  
  
  CONCLUSIONS
  AP enhanced the capacity of MSCs to repair infarcted myocardium, attributable to increased cell survival and angiogenesis.
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Wang
authors.forename: Aina
authors.initials: A
authors.lastname: He
authors.forename: Xinyang
authors.initials: X
authors.lastname: Hu
authors.forename: Yun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Chun
authors.initials: C
authors.lastname: Gui
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
authors.forename: Han
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D000860:Hypoxia / Q000503:physiopathology; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley