title: [Determination of residual solvents in ranolazine by headspace gas chromatography].
abstract: OBJECTIVE
  To determine the contents of the residual solvents, methanol, ethanol, toluene, dichloromethane and dioxane in ranolazine raw material.
  
  
  METHODS
  Headspace gas chromatography was used to analyze the residual solvents quantitatively. Samples were analyzed on an HP-INNOWAX column with column temperature at 45 degrees Celsius; using water as solvent.
  
  
  RESULTS
  Five residual solvents were completely separated. The liner range and recoveries were satisfied. RSD of precision and accuracy was less than 8% with average recoveries between 87.1% and 105.6%.
  
  
  CONCLUSIONS
  The method could be used for the quality control of ranolazine raw material.
authors.affiliation: 421 Hospital of PLA, Guangzhou 510318, China. yeyl1978@163.com
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Ye
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Yang
mesh_terms: D000083:Acetanilides / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000032:analysis; D000431:Ethanol / Q000032:analysis; D000432:Methanol / Q000032:analysis; D010879:Piperazines / Q000032:analysis*; D000069458:Ranolazine; D015203:Reproducibility of Results; D012997:Solvents / Q000032:analysis*; D014050:Toluene / Q000032:analysis
chemical_list: D000083:Acetanilides; D004791:Enzyme Inhibitors; D010879:Piperazines; D012997:Solvents; D014050:Toluene; D000431:Ethanol; D000069458:Ranolazine; D000432:Methanol