Free radicals and antioxidants in inflammatory processes and ischemia-reperfusion injury.
This article discusses the current understanding of the role of free radicals and antioxidants in inflammatory processes and in ischemia reperfusion injury. It begins by describing the manifestations of acute inflammation and outlining the cellular events that occur during inflammation. It then describes the biochemical mediators of inflammation with special attention to nitric oxide. It details the process of hypoxia reperfusion injury, the enzymes involved, its treatment, and studies involving specific hypoxia reperfusion injuries in various animal species.
Vajdovich
Peter
P
Department of Internal Medicine and Clinics, Szent István University, H-1078, István u. 2., P.O. Box 1400, Budapest, Hungary. vajdovich.peter@aotk.szie.hu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002415:Cats; D002417:Cattle; D004285:Dogs; D005609:Free Radicals / Q000378:metabolism*; D006736:Horses; D000860:Hypoxia; D007249:Inflammation / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism*; D013045:Species Specificity
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D009569:Nitric Oxide