title: [Genetic polymorphism of the PRODH and 5-HT(2A) receptor gene in Korean-Chinese and Han nationality in Chinese Yanbian area].
abstract: OBJECTIVE
  To investigate the polymorphisms distribution of genes related with mental diseases, such as proline dehydrogenase gene (PRODH) and serotonin 2A(5-HT(2A)) receptor gene, among Korean-Chinese and Han nationality in Chinese Yanbian area.
  
  
  METHODS
  By utilizing techniques of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the polymorphisms for -1945 region of the PRODH gene and -1438 region of the 5-HT(2A) receptor gene were analyzed.
  
  
  RESULTS
  The PRODH genotype frequencies of MM, Mm and mm in Korean-Chinese population were 61.4%,34.4%,4.2% respectively, the allele frequencies were 0.786 for M and 0.214 for m respectively, and those in Han population were 55.2%,38.5%,6.3%, 0.745 and 0.255 respectively. The 5-HT(2A) receptor gene genotype frequencies of AA, AG and GG in Korean-Chinese population were 15.6%,67.7%,16.7% respectively, the allele frequencies were 0.495 for A and 0.505 for G respectively, and those in Han population were 11.5%,65.6%,22.9%, 0.443 for A and 0.557 for G.
  
  
  CONCLUSIONS
  All of the genotype distribution of both loci in Chinese Korean and Han nationality in Yanbian area meet Hardy-Weinberg equilibrium, and show stronger ability in human identity. The data obtained can be used in human identity, paternity testing and Chinese Korean ethnic group study.
authors.affiliation: Department of Neurology, Yanbian Brain Hospital, Yanji, Jilin, 133000 People's Republic of China.
authors.forename: Wan-kui
authors.initials: WK
authors.lastname: Jiang
authors.forename: Qing-song
authors.initials: QS
authors.lastname: Xu
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Piao
mesh_terms: D000328:Adult; D000818:Animals; D002681:China; D004586:Electrophoresis; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D001523:Mental Disorders / Q000235:genetics; D051379:Mice; D011110:Polymorphism, Genetic; D011394:Proline Oxidase / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011394:Proline Oxidase