[(123)I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor.
Mixed-type tremors pose a clinical diagnostic challenge. The aim of the study was to better characterize patients with combined postural and rest tremor. Patients were categorized into four groups: essential tremor (ET) (n = 7), combined rest + postural tremor (n = 17), PD (n = 17), and control subjects (n = 9). All underwent the University of Pennsylvania Smell Identification Test (UPSIT). The mixed-tremor group was also evaluated with SPECT imaging using the dopamine transporter (DaT) ligand (123)I-labeled FP-CIT. There was no significant difference in olfaction scores between the mixed tremor and essential tremor groups (23.2 +/- 6.6 vs 21.7 +/- 4.9) or between these groups and controls (27.2 +/- 5.0). The patients with PD had significantly lower scores than all the other groups (13.7 +/- 5.4, p < 0.001). Of the 12 patients with mixed tremor evaluated by SPECT, 9 had normal findings. This study suggests that rest tremor is part of the spectrum of ET, even in patients with long-standing disease. However, in a minority of patients, there might be transformation of ET-PD.
Djaldetti
R
R
Department of Neurology, Beilinson Campus, Petah Tiqwa, Israel. ruthdjal@clalit.org.il
Nageris
B I
BI
Lorberboym
M
M
Treves
T A
TA
Melamed
E
E
Yaniv
E
E
D003937:Diagnosis, Differential; D003955:Diagnostic Tests, Routine; D020329:Essential Tremor / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D012903:Smell / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon; D014202:Tremor / Q000175:diagnosis*; D014326:Tropanes
D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane