[Preparation and characterization of solid lipid nanoparticles of norcantharidin].
OBJECTIVE
To prepare and characterize the solid lipid nanoparticles containing norcantharidin.


METHODS
Entrapment efficiency was studied to choose the best method of preparing norcantharidin solid lipid nanoparticles. The physico-chemical properties of norcantharidin solid lipid nanoparticles were investigated.


RESULTS
The entrapment efficiency of norcantharidin in solid lipid nanoparticles was 54.6%, the average particle diameter was 190 nm, and it was stable at 4 degrees C for 3 months.


CONCLUSIONS
Solid lipid nanoparticles of norcantharidin prepared has high entrapment efficiency and good stability.
Tian
Hai-yan
HY
Faculty of Pharmaceutical Science, Shandong University, Jinan 250012, China.
Zhai
Guang-xi
GX
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D002193:Cantharidin / Q000031:analogs & derivatives / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012997:Solvents; D013229:Stearic Acids / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014465:Ultrasonics
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D008055:Lipids; D012997:Solvents; D013229:Stearic Acids; D002193:Cantharidin