title: Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
abstract: Rhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to the development of effective therapies has been the lack of a small-animal model for rhinovirus infection. Of the 100 known rhinovirus serotypes, 90% (the major group) use human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor and do not bind mouse ICAM-1; the remaining 10% (the minor group) use a member of the low-density lipoprotein receptor family and can bind the mouse counterpart. Here we describe three novel mouse models of rhinovirus infection: minor-group rhinovirus infection of BALB/c mice, major-group rhinovirus infection of transgenic BALB/c mice expressing a mouse-human ICAM-1 chimera and rhinovirus-induced exacerbation of allergic airway inflammation. These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.
authors.affiliation: Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK.
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Bartlett
authors.forename: Ross P
authors.initials: RP
authors.lastname: Walton
authors.forename: Michael R
authors.initials: MR
authors.lastname: Edwards
authors.forename: Juliya
authors.initials: J
authors.lastname: Aniscenko
authors.forename: Gaetano
authors.initials: G
authors.lastname: Caramori
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Nicholas
authors.initials: N
authors.lastname: Glanville
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Choy
authors.forename: Patrick
authors.initials: P
authors.lastname: Jourdan
authors.forename: Jerome
authors.initials: J
authors.lastname: Burnet
authors.forename: Tobias J
authors.initials: TJ
authors.lastname: Tuthill
authors.forename: Michael S
authors.initials: MS
authors.lastname: Pedrick
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hurle
authors.forename: Chris
authors.initials: C
authors.lastname: Plumpton
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Sharp
authors.forename: James N
authors.initials: JN
authors.lastname: Bussell
authors.forename: Dallas M
authors.initials: DM
authors.lastname: Swallow
authors.forename: Jurgen
authors.initials: J
authors.lastname: Schwarze
authors.forename: Bruno
authors.initials: B
authors.lastname: Guy
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Almond
authors.forename: Peter K
authors.initials: PK
authors.lastname: Jeffery
authors.forename: Clare M
authors.initials: CM
authors.lastname: Lloyd
authors.forename: Alberto
authors.initials: A
authors.lastname: Papi
authors.forename: Richard A
authors.initials: RA
authors.lastname: Killington
authors.forename: David J
authors.initials: DJ
authors.lastname: Rowlands
authors.forename: Edward D
authors.initials: ED
authors.lastname: Blair
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Clarke
authors.forename: Sebastian L
authors.initials: SL
authors.lastname: Johnston
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000821:virology; D018925:Chemokines / Q000096:biosynthesis / Q000276:immunology; D002630:Chemotactic Factors / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology / Q000528:radiation effects; D004195:Disease Models, Animal; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000821:virology*; D007113:Immunity, Innate / Q000528:radiation effects; D007249:Inflammation; D018836:Inflammation Mediators / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D009093:Mucus / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology / Q000528:radiation effects; D010850:Picornaviridae Infections / Q000821:virology*; D012137:Respiratory System / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects / Q000821:virology*; D012229:Rhinovirus / Q000502:physiology* / Q000528:radiation effects; D018417:Th1 Cells / Q000276:immunology / Q000528:radiation effects; D018418:Th2 Cells / Q000276:immunology / Q000528:radiation effects; D014466:Ultraviolet Rays; D038301:Virus Inactivation / Q000528:radiation effects; D014779:Virus Replication / Q000528:radiation effects
chemical_list: D018925:Chemokines; D002630:Chemotactic Factors; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1