HIVcleave: a web-server for predicting human immunodeficiency virus protease cleavage sites in proteins.
According to the ''distorted key theory'' [K.C. Chou, Analytical Biochemistry, 233 (1996) 1-14], the information of cleavage sites of proteins by HIV (human immunodeficiency virus) protease is very useful for finding effective inhibitors against HIV, the culprit of AIDS (acquired immunodeficiency syndrome). To meet the increasing need in this regard, a web-server called HIVcleave was established at http://chou.med.harvard.edu/bioinf/HIV/. In this note we provide a step-to-step guide for how to use HIVcleave to identify the cleavage sites of a query protein sequence by HIV-1 and HIV-2 proteases, respectively.
Shen
Hong-Bin
HB
Gordon Life Science Institute, San Diego, CA 92130, USA.
Chou
Kuo-Chen
KC
D000595:Amino Acid Sequence; D001665:Binding Sites; D003201:Computers; D016333:HIV Protease / Q000378:metabolism*; D006801:Humans; D020407:Internet; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D010455:Peptides; D016333:HIV Protease