title: Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma.
abstract: FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MAL andT1 BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.
authors.forename: Patrick
authors.initials: P
authors.lastname: Adam
authors.forename: Eugenia
authors.initials: E
authors.lastname: Haralambieva
authors.forename: Martina
authors.initials: M
authors.lastname: Hartmann
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Mao
authors.forename: German
authors.initials: G
authors.lastname: Ott
authors.forename: Andreas
authors.initials: A
authors.lastname: Rosenwald
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D017403:In Situ Hybridization; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics*; D008297:Male; D040641:Quantitative Trait Loci / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D012189:Retrospective Studies; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D012097:Repressor Proteins