One-pot synthesis of diarylalkynes using palladium-catalyzed sonogashira reaction and decarboxylative coupling of sp carbon and sp2 carbon.
Decarboxylative coupling of sp-sp2 carbons is possible by palladium catalyst. Employing propiolic acid (1) as a difunctional alkyne, and using the consecutive reactions of the Sonogashira reaction and the decarboxylative coupling, unsymmetrically substituted diaryl alkynes were obtained in moderate to good yield.
Moon
Jeongju
J
Department of Chemistry, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju, 500-757, Republic of Korea.
Jeong
Miso
M
Nam
Hyungoog
H
Ju
Jinhun
J
Moon
Joong Ho
JH
Jung
Hyun Min
HM
Lee
Sunwoo
S
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*
D000480:Alkynes; D011422:Propionates; D010165:Palladium; D002244:Carbon; C011537:propiolic acid