Mitochondria--a nexus for aging, calorie restriction, and sirtuins?
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
Guarente
Leonard
L
Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA. leng@mit.edu
D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D037761:Sirtuins
D037761:Sirtuins