The effect of chitosan on the stability and morphological parameters of tablets with Epilobium parviflorum Schreb. extract.
The study is a continuation of research on manufacturing oral solid drug form containing extract from Epilobium parviflorum Schreb. This study aims at investigating the usefulness of selected high-molecular substances with particular consideration of chitosan (Ch), silicified microcrystalline cellulose (Prosolv) and croscarmellose sodium (Vivasol) as a carrier of E. parviflorum Schreb. extract in oral solid drug form in the process of direct tableting. In one series the alternative technological process (with initial granulation) was applied. The polymer carriers of extract were selected so as to obtain shorter disintegration time in relation to the earlier published studies and stability after longer time of storage. The effect of chitosan was estimated on selected morphological parameters of practical relevance during storage. The obtained results allow to state that the applied high-molecular adjuvant substances proved to be useful in adequate proportions in the production of tablets from dry extract from Epilobium parviflorum Schreb. through direct pressing of the tablet mass. The tablet properties in all series were in accordance with obligatory standards also after longer time of storage (12-month). The tablets formed from E. parviflorum Schreb. extract with chitosan can be included into preparations of sustained release time of the biologically active substances.
Marczyński
Zbigniew
Z
Department of Pharmacy and Applied Pharmacy, Medical University of Lodz.
Bodek
Kazimiera Henryka
KH
D000284:Administration, Oral; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D031666:Epilobium / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D010936:Plant Extracts / Q000737:chemistry*; D012995:Solubility / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D010936:Plant Extracts; D013607:Tablets; D048271:Chitosan