Sickle cell patients are characterized by a reduced glycocalyx volume.
The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSbeta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.
van Beers
Eduard J
EJ
Nieuwdorp
Max
M
Duits
Ashley J
AJ
Evers
Ludo M
LM
Schnog
John-John B
JJ
Biemond
Bart J
BJ
D000328:Adult; D000755:Anemia, Sickle Cell / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D019276:Glycocalyx / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male