title: 1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma.
abstract: Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
authors.affiliation: Department of Pediatric Surgery, Fujita Health University, Toyoake, Aichi, Japan. mhibi@fujita-hu.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Hibi
authors.forename: Hibi
authors.initials: H
authors.lastname: Masahito
authors.forename: Fujio
authors.initials: F
authors.lastname: Hara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tomishige
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nishida
authors.forename: Takazumi
authors.initials: T
authors.lastname: Kato
authors.forename: Naotake
authors.initials: N
authors.lastname: Okumura
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kato
mesh_terms: D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002648:Child; D004407:Dysgerminoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery
chemical_list: D002117:Calcitriol; D002118:Calcium