[Consomic approach to blood pressure and metabolic diseases in Lyon hypertensive rats].
Genetically hypertensive rats of the Lyon strain (LH) have both high blood pressure and a metabolic syndrome. Linkage studies have disclosed quantitative trait loci of interest on chromosomes 2, 13 and 17. In the present work we designed consomic rats, i.e. LH rats in which a full chromosome was replaced by the same chromosome originating from the Brown-Norway (BN) normotensive strain. Rats consomic for chromosome 17 (LH-17BN) exhibited slightly but significantly lower blood pressure, which remained sensitive to an oral salt load. The cholesterol level was unaffected, while the triglyceride level was markedly depressed. This consomic approach seems to be of value for studying polygenic diseases such as hypertension and the metabolic syndrome. In the case of LH rats, our results confirm the functional importance of the loci identified on chromosome 17.
Sassard
Jean
J
Académie nationale de médecine.
Gilibert
Sophie
S
Bataillard
Alain
A
D000367:Age Factors; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics*; D010641:Phenotype; D051381:Rats; D011914:Rats, Inbred BN / Q000235:genetics; D011919:Rats, Inbred Strains / Q000235:genetics; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol