Cortical thickness abnormality in juvenile myoclonic epilepsy.
Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.
Tae
Woo Suk
WS
Dept. of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.
Kim
Sun Hyung
SH
Joo
Eun Yun
EY
Han
Sun Jung
SJ
Kim
In Yong
IY
Kim
Sun I
SI
Lee
Jong-Min
JM
Hong
Seung Bong
SB
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009421:Nervous System Malformations / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000002:abnormalities / Q000473:pathology