title: Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix.
abstract: BACKGROUND
  Prognostic significance of squamous cell carcinoma antigen (SCC-Ag), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA) and neopterin in cervical cancer patients was compared.
  
  
  METHODS
  Pretreatment concentrations were determined in 138 women.
  
  
  RESULTS
  Median age was 52 years, 85% squamous cell carcinomas, 15% adeno- or adenosquamous carcinomas were seen. In 36% Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, 24% stage II, 32% stage III and 8% stage IV was diagnosed. TPA was elevated in 22%, SCC in 68%, CEA in 42% and neopterin in 29%. These patients showed significantly worse overall survival in univariate analysis (p<0.001). TPA remained as independent prognostic factor in multivariate analysis.
  
  
  CONCLUSIONS
  Elevation of TPA was associated with worse overall survival.
authors.affiliation: Medical University of Innsbruck, Department of Obstetrics and Gynaecology, Anichstrasse 35, 6020 Innsbruck, Austria. birgit.volgger@i-med.ac.at
authors.forename: Birgit
authors.initials: B
authors.lastname: Volgger
authors.forename: Coskun
authors.initials: C
authors.lastname: Aspisirengil
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Genser-Krimbacher
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ciresa-Koenig
authors.forename: Günter
authors.initials: G
authors.lastname: Daxenbichler
authors.forename: Dietmar
authors.initials: D
authors.lastname: Fuchs
authors.forename: Gudrun
authors.initials: G
authors.lastname: Windbichler
authors.forename: Christian
authors.initials: C
authors.lastname: Marth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D019798:Neopterin / Q000032:analysis*; D011379:Prognosis; D015843:Serpins / Q000032:analysis*; D016019:Survival Analysis; D019396:Tissue Polypeptide Antigen / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000401:mortality
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; D019396:Tissue Polypeptide Antigen; C051072:squamous cell carcinoma-related antigen; D019798:Neopterin