title: Anticancer constituents from the roots of Rubia cordifolia L.
abstract: Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Soon Ja
authors.initials: SJ
authors.lastname: Jung
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Jung
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fang
authors.forename: Chong Soon
authors.initials: CS
authors.lastname: Lee
authors.forename: Chang Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Dong Cheul
authors.initials: DC
authors.lastname: Moon
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Mi Ryeo
authors.initials: MR
authors.lastname: Kim
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology*; D045470:Rubia / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D009284:Naphthols; D011714:Pyrans; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C527316:epoxymollugin