title: Fibrinogen gamma' in ischemic stroke: a case-control study.
abstract: OBJECTIVE
  To determine the contribution of fibrinogen gamma' levels and FGG haplotypes to ischemic stroke.
  
  
  METHODS
  Associations between fibrinogen gamma' levels, fibrinogen gamma'/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls.
  
  
  RESULTS
  Fibrinogen gamma'/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen gamma'/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen gamma'/total fibrinogen ratio, but not with risk of stroke.
  
  
  CONCLUSIONS
  Fibrinogen gamma'/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.
authors.forename: Elim Y L
authors.initials: EY
authors.lastname: Cheung
authors.forename: Shirley
authors.initials: S
authors.lastname: Uitte de Willige
authors.forename: Hans L
authors.initials: HL
authors.lastname: Vos
authors.forename: Frank W G
authors.initials: FW
authors.lastname: Leebeek
authors.forename: Diederik W J
authors.initials: DW
authors.lastname: Dippel
authors.forename: Rogier M
authors.initials: RM
authors.lastname: Bertina
authors.forename: Moniek P M
authors.initials: MP
authors.lastname: de Maat
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D014644:Genetic Variation; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000097:blood* / Q000209:etiology* / Q000517:prevention & control
chemical_list: D015241:Fibrinogens, Abnormal; C527521:fibrinogen gamma'