Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study.
To clarify the clinical features of adult patients with acute leukemia (AL) with 11q23 abnormalities, we performed a retrospective analysis of data from 58 adult Japanese patients: 51 with acute myeloid leukemia (AML), and 7 with acute lymphoblastic leukemia (ALL). The incidences according to fusion partners in AML were: t(9;11), 31.3%; t(11;19), 27.4%; t(6;11), 21.5%. The incidence of patients with t(11;19) was higher than those in the US and Europe, and the incidence of t(4;11) was lower than that in childhood. The results indicated the poor prognosis of AML with 11q23 abnormalities regardless of the fusion partners. AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo-HSCT, although the differences were not statistically significant (P = 0.322 for DFS, P = 0.138 for OS). This result suggests that treatment strategies including allo-HSCT may be considered in the first CR in cases of AML with 11q23 abnormalities. However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities.
Tamai
Hayato
H
Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan. s6056@nms.ac.jp.
Yamaguchi
Hiroki
H
Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
Hamaguchi
Hiroyuki
H
Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan.
Yagasaki
Fumiharu
F
Department of Hematology, Saitama Medical University, Saitama, Japan.
Bessho
Masami
M
Department of Hematology, Saitama Medical University, Saitama, Japan.
Kobayashi
Takeshi
T
Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Akiyama
Hideki
H
Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Sakamaki
Hisashi
H
Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Takahashi
Satoshi
S
Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Tojo
Arinobu
A
Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ohmine
Ken
K
Department of Hematology, Jichi Medical School, Tochigi, Japan.
Ozawa
Keiya
K
Department of Hematology, Jichi Medical School, Tochigi, Japan.
Okumura
Hirokazu
H
Department of Hematology, Kanazawa University, Ishikawa, Japan.
Nakao
Shinji
S
Department of Hematology, Kanazawa University, Ishikawa, Japan.
Arai
Ayako
A
Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan.
Miura
Osamu
O
Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan.
Toyota
Shigeo
S
Department of Hematology, Yokosuka Kyosai Hospital, Kanagawa, Japan.
Gomi
Seiji
S
Department of Hematology, Yokohama Minami Kyosai Hospital, Kanagawa, Japan.
Murai
Yoshiro
Y
Department of Hematology, Tama Hokubu Medical Center, Tokyo, Japan.
Usui
Noriko
N
Department of Hematology, The Jikei University, Tokyo, Japan.
Miyazawa
Keisuke
K
Department of Hematology, Tokyo Medical University, Tokyo, Japan.
Ohyashiki
Kazuma
K
Department of Hematology, Tokyo Medical University, Tokyo, Japan.
Takahashi
Naoto
N
Department of Internal Medicine, Akita University, Akita, Japan.
Sawada
Kenichi
K
Department of Internal Medicine, Akita University, Akita, Japan.
Kato
Atsushi
A
Department of Hematology, Juntendo University, Tokyo, Japan.
Oshimi
Kazuo
K
Department of Hematology, Juntendo University, Tokyo, Japan.
Inokuchi
Koiti
K
Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
Dan
Kazuo
K
Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
D000328:Adult; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000628:therapy; D012189:Retrospective Studies; D014178:Translocation, Genetic / Q000235:genetics*; D014184:Transplantation, Homologous