Thalamocortical transformations of periodic stimuli: the effect of stimulus velocity and synaptic short-term depression in the vibrissa-barrel system.
Recent works on the response of barrel neurons to periodic deflections of the rat vibrissae have shown that the stimulus velocity is encoded in the corti cal spike rate (Pinto et al., Journal of Neurophysiology, 83(3), 1158-1166, 2000; Arabzadeh et al., Journal of Neuroscience, 23(27), 9146-9154, 2003). Other studies have reported that repetitive pulse stimulation produces band-pass filtering of the barrel response rate centered around 7-10 Hz (Garabedian et al., Journal of Neurophysiology, 90, 1379-1391, 2003) whereas sinusoidal stimulation gives an increasing rate up to 350 Hz (Arabzadeh et al., Journal of Neuroscience, 23(27), 9146-9154, 2003). To explore the mechanisms underlying these results we propose a simple computational model consisting in an ensemble of cells in the ventro-posterior medial thalamic nucleus (VPm) encoding the stimulus velocity in the temporal profile of their response, connected to a single barrel cell through synapses showing short-term depression. With sinusoidal stimulation, encoding the velocity in VPm facilitates the response as the stimulus frequency increases and it causes the velocity to be encoded in the cortical rate in the frequency range 20-100 Hz. Synaptic depression does not suppress the response with sinusoidal stimulation but it produces a band-pass behavior using repetitive pulses. We also found that the passive properties of the cell membrane eventually suppress the response to sinusoidal stimulation at high frequencies, something not observed experimentally. We argue that network effects not included here must be important in sustaining the response at those frequencies.
de la Rocha
Jaime
J
Dto. de Física Teórica, Universidad Autónoma de Madrid, 28049, Madrid, Spain. jrocha@cns.nyu.edu
Parga
Néstor
N
D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005106:Exploratory Behavior / Q000502:physiology*; D020645:Mediodorsal Thalamic Nucleus / Q000502:physiology*; D008959:Models, Neurological; D009068:Movement; D009415:Nerve Net / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology*; D010507:Periodicity; D010812:Physical Stimulation; D020656:Posterior Thalamic Nuclei / Q000502:physiology*; D051381:Rats; D013269:Stochastic Processes; D013997:Time Factors; D014110:Touch / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology*