title: Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction.
abstract: The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.
authors.affiliation: Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ikuta
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.forename: Tatsurhiro
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000327:Adsorption; D000818:Animals; D001011:Aorta; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005070:Evans Blue; D008823:Micelles; D053758:Nanoparticles; D011108:Polymers; D013552:Swine
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D005070:Evans Blue; D004317:Doxorubicin