[Taxon-specific regulation of SOS-response in gamma-proteobacteria].
SOS-response system is a cascade of reactions induced by DNA damage in a cell. Genes participate in these reactions are regulated by the LexA protein binding to specific sequence in their upstream regions. The criterion for selection of genes putatively responsible for the SOS-response is the presence of such sequence. Genes with taxon-specific regulation in Enterobacteriales, Pasteurellales, Vibrionales, Pseudomonadales and Alteromonadales were analyzed using comparative genomic approaches. Some genes have conserved sites in regulatory region and suitable function, although their function in SOS-response has not been studied in experiment. The list of such genes includes mfd, which encodes a product repairing the mother chain in case of DNA damage-caused transcription stop; VC0082, which encodes a recombinase, and VP2449, responsible for xenobiotics resistance. Overall, this study characterized the content and evolution of the LexA regulon in gamma-proteobacteria are described here.
Sycheva
L V
LV
Permina
E A
EA
Gel'fand
M S
MS
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D005798:Genes, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics* / Q000378:metabolism; D020218:Response Elements / Q000235:genetics*; D013014:SOS Response, Genetics / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein