Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema.
We describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. We postulate that these imaging findings were the result of intramyelinic edema, previously described in experimental animal models of isoniazid toxicity.
Hawkes
Michael
M
Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Kitai
Ian
I
Blaser
Susan
S
Cohen
Eyal
E
Bitnun
Ari
A
Fluss
Joel
J
Tran
Dat
D
D000995:Antitubercular Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001772:Blood Cell Count; D001929:Brain Edema / Q000139:chemically induced* / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
D000995:Antitubercular Agents; D007538:Isoniazid