Gastrointestinal stromal tumors: a single institution experience of 50 cases.
BACKGROUND
Understanding the molecular pathogenesis of gastrointestinal stromal tumors (GIST) has led to targeted therapy using imatinib mesylate (IM). This retrospective series summarizes our short-term experience with 50 cases of GIST.


METHODS
Case records of patients with GIST were analyzed. Tumor size, response to imatinib, and adverse events were evaluated every 3 months.


RESULTS
The median age was 50 years (range 28-73). Stomach was the most common site (n=15). Thirty (60%) patients had complete resection of tumor with median progression free survival (PFS) of 12 months. The difference in PFS between intermediate and high risk groups was significant for patients who underwent resection (p=0.016). Thirty-five patients with advanced disease were administered IM 400 mg daily, and complete response was noted in 4 (11.8%); 13 (38.2%) each had partial response and stable disease, and 5 (14.8%) had progressive disease. Responses were not different in groups based on sex, site of primary tumor and number of metastatic sites. At a median follow up of 10 months, 72% patients continue to maintain response.


CONCLUSIONS
This short-term study in patients with GIST describes response to therapy with imatinib in these patients.
Rajappa
Senthil
S
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500 082, India. siddharth142@sify.com
Muppavarapu
Krishna Mohan
KM
Uppin
Shantveer
S
Digumarti
Raghunadharao
R
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate