Effects of 1-deamino-1-monocarb-arginine-vasotocin on sodium ion and water excretion by rat kidneys.
Injection of 1-deamino-1-monocarb-arginine-vasotocin (0.05 microg/100 g body weight) to alert rats caused increased natriuresis, diuresis, and reabsorption of osmotically free water. Injection of furosemide (0.5 mg/100 g body weight) increased Na(+) excretion and did not increase reabsorption of osmotically free water. 1-deamino-1-monocarb-arginine-vasotocin in molar conversion increased natriuresis by almost 6 x 10(4) times more effectively than furosemide.
Kanashkina
T A
TA
Laboratory of Kidney Physiology, I M Setchenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia.
Shakhmatova
E I
EI
Natochin
Yu V
YV
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014668:Vasotocin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014668:Vasotocin