Structure-activity relationship of triterpenes and triterpenoid glycosides against tobacco mosaic virus.
A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according to the results of bio-activity screening. Besides, the EC(50) values of those compounds having higher activities were measured.
Zhang
Zheng-Kun
ZK
Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China.
Ouyang
Ming-An
MA
Wu
Zu-Jian
ZJ
Lin
Qi-Ying
QY
Xie
Lian-Hui
LH
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000998:Antiviral Agents; D006027:Glycosides; D014315:Triterpenes