title: The influence of silica on pore diameter and distribution in PLA scaffolds produced using supercritical CO2.
abstract: Macroporous polylactide (PLA) scaffolds were fabricated using a supercritical CO2 foaming process. The addition of silica particles to the polymer matrix resulted in a significant modification in the pore size distribution exhibited by the scaffold. In the absence of silica, the scaffolds contained pores between 88 microm and 980 microm in diameter as determined using X-ray computed microtomography. The addition of silica at only 2 wt% resulted in the elimination of pores of >620 microm, with no significant influence on the total porosity of the material. This effect was attributed to the silica nucleating the formation of gas bubbles in the polymeric material. Although the addition of further silica to the scaffold resulted in a further reduction in modal pore diameter, when more than 20 wt% was added to the matrix little additional effect was noted. In addition to enabling some control over pore diameter, mineral deposition was shown to occur considerably more rapidly on the silica-modified scaffolds than on those containing no silica.
authors.affiliation: Department of Chemical Engineering, Centre for Formulation Engineering, University of Birmingham, Edgbaston B15 2TT, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Collins
authors.forename: G A
authors.initials: GA
authors.lastname: Leeke
authors.forename: R H
authors.initials: RH
authors.lastname: Bridson
authors.forename: F
authors.initials: F
authors.lastname: Hassan
authors.forename: L M
authors.initials: LM
authors.lastname: Grover
mesh_terms: D001698:Biomedical Engineering / Q000379:methods; D001842:Bone and Bones / Q000378:metabolism; D002245:Carbon Dioxide / Q000737:chemistry*; D004867:Equipment Design; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents; D013499:Surface Properties; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D011091:Polyesters; D011108:Polymers; D012997:Solvents; D002245:Carbon Dioxide; C033616:poly(lactide); D012822:Silicon Dioxide