title: Cortical thickness abnormality in juvenile myoclonic epilepsy.
abstract: Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.
authors.affiliation: Dept. of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.forename: Sun Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Eun Yun
authors.initials: EY
authors.lastname: Joo
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Han
authors.forename: In Yong
authors.initials: IY
authors.lastname: Kim
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009421:Nervous System Malformations / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000002:abnormalities / Q000473:pathology