title: Platelet-rich fibrin: evolution of a second-generation platelet concentrate.
abstract: Platelet-rich plasma (PRP) is a platelet concentrate that has been used widely to accelerate soft-tissue and hard-tissue healing. The preparation of PRP has been described by several authors. Platelet-rich fibrin (PRF) was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. Its chief advantages include ease of preparation and lack of biochemical handling of blood, which makes this preparation strictly autologous. This article describes the evolution of this novel platelet concentrate, referred to as PRF.
authors.affiliation: Department of Periodontics, Meenakshiammal Dental College and Hospital, Maduravoyal, Chennai, India. sunitha.smiles@yahoo.com
authors.forename: V
authors.initials: V
authors.lastname: Sunitha Raja
authors.forename: E
authors.initials: E
authors.lastname: Munirathnam Naidu
mesh_terms: D000818:Animals; D001792:Blood Platelets; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation; D002469:Cell Separation / Q000379:methods; D005337:Fibrin; D006801:Humans; D053657:Platelet-Rich Plasma
chemical_list: D005337:Fibrin