title: Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine.
abstract: Hydroxyclemastine was targeted as a versatile analogue of clemastine with H1 receptor antagonist activity. Stereoselective synthesis of (-)-hydroxyclemastine was performed in which the key step was chelation-controlled diastereoselective 1,2-addition of Grignard reagent to alpha-alkoxyketone.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Jung Wha
authors.initials: JW
authors.lastname: Jung
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
mesh_terms: D002974:Clemastine / Q000138:chemical synthesis*; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D006634:Histamine H1 Antagonists; D002974:Clemastine