[Evaluation of NT-proBNP as an early biological marker of cardiac dysfunction in septic shock].
OBJECTIVE
To evaluate the NT-proBNP as a biological diagnosis marker of the myocardial dysfunction in septic shock.


METHODS
Non-randomized prospective clinical study with written assent. The analysis of the data obtained was retrospective.


METHODS
All the patients with septic shock in the beginning of evolution (less than 24h) were included. Patients with cardiac insufficiency, insufficient respiratory function and chronic renal insufficiency as well as cirrhotic patients were excluded. Among patients in shock, a NT-proBNP concentration measurement and a cardiac echography by transthoracic way were carried out at inclusion. The rates of NT-proBNP were compared with the data of the echography.


RESULTS
Thirty-three patients in septic shock were included. On the whole of the collective, whether or not there is a cardiac dysfunction, the rates of NT-proBNP are not significantly different (11,306+/-16,196 pg/ml versus 10,697+/-12,346 pg/ml). By eliminating the patients with severe renal failure, we show that the NT-proBNP is non-significantly increased in the event of right and/or left ventricular failure (5751+/-4180 pg/ml versus 1,256+/-999 pg/ml).


CONCLUSIONS
The NT-proBNP can help to detect the cardiogenic share sometimes implied in the haemodynamic failure of the septic shock. However, because of the influence of the renal insufficiency and the respiratory, cardiologic and hepatic comorbidities on its secretion, its use cannot be recommended for patients in septic shock.
Verdier
B
B
Département d'anesthésiologie-réanimation chirurgicale et Samu, université de Rouen, institut hospitalo-universitaire de recherche biomédicale, CHU de Rouen, 1, rue de Germont, 76031 Rouen, France. bruno.verdier@chu-rouen.fr
Chauvet
J-L
JL
Tamion
F
F
Cauliez
B
B
Lavoinne
A
A
Veber
B
B
Dureuil
B
B
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D012772:Shock, Septic / Q000097:blood / Q000150:complications; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D018497:Ventricular Dysfunction, Right / Q000097:blood* / Q000175:diagnosis / Q000209:etiology
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain