title: Aortic valve replacement in a young patient with essential thrombocytosis.
abstract: Essential Thrombocythcythaemia (ET) is an uncommon type of myeloproliferative disorder, characterised by both thrombotic and haemorrhagic diathesis. No clear guidelines exist for the pre- and post-operative management of patients undergoing cardiac surgery in the haematological and surgical literature. This condition has profound implications in patients undergoing cardiac surgery with the use of cardiopulmonary bypass, where heparin is used for anti-coagulation. This dilemma is further compounded in the setting of a young patient undergoing aortic valve replacement (AVR), where insertion of a mechanical prosthesis would be the procedure of choice. This would require life-long anticoagulation with warfarin which can predispose these patients to catastrophic bleeding. Using a tissue valve will subject the patient to multiple redo operations in the patient's lifetime. We report a young patient with ET requiring AVR and discuss the dilemmas surrounding the choice of prosthesis in this patient.
authors.affiliation: Department of Cardiothoracic Surgery, Southampton University Hospitals NHS Trust, Southampton, UK. kashif_a77@hotmail.com
authors.forename: Kashif
authors.initials: K
authors.lastname: Ahmed
authors.forename: Hunaid A
authors.initials: HA
authors.lastname: Vohra
authors.forename: Alison
authors.initials: A
authors.lastname: Milne
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Langley
mesh_terms: D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D004452:Echocardiography; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D013920:Thrombocythemia, Essential / Q000150:complications*; D055815:Young Adult