title: Sickle cell patients are characterized by a reduced glycocalyx volume.
abstract: The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSbeta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.
authors.forename: Eduard J
authors.initials: EJ
authors.lastname: van Beers
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Duits
authors.forename: Ludo M
authors.initials: LM
authors.lastname: Evers
authors.forename: John-John B
authors.initials: JJ
authors.lastname: Schnog
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Biemond
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D019276:Glycocalyx / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male