title: Tumor lysis associated with dexamethasone use in a child with leukemia.
abstract: Postoperative nausea and vomiting (PONV) occurs in every third patient undergoing general anesthesia without PONV prophylaxis. Antiemetic prophylaxis with dexamethasone is commonly used in patients at moderate risk. We present a case in which PONV prophylaxis with a single dose of dexamethasone led to tumor lysis in a patient with acute leukemia. In case of a cancer patient at moderate risk for PONV, the anesthesiologist should contact the oncologist first, or use other antiemetic drugs such as antiserotoninergic agents for PONV prophylaxis.
authors.affiliation: Zentrum Anästhesiologie, Medizinische Hochschule Hannover, Hannover, Germany. osthaus.alexander@mh-hannover.de
authors.forename: Wilhelm Alexander
authors.initials: WA
authors.lastname: Osthaus
authors.forename: Christin
authors.initials: C
authors.lastname: Linderkamp
authors.forename: Christoph
authors.initials: C
authors.lastname: Bünte
authors.forename: Bjorn
authors.initials: B
authors.lastname: Jüttner
authors.forename: Robert
authors.initials: R
authors.lastname: Sümpelmann
mesh_terms: D000932:Antiemetics / Q000009:adverse effects*; D002648:Child; D003907:Dexamethasone / Q000009:adverse effects*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D054448:Precursor Cells, B-Lymphoid; D015275:Tumor Lysis Syndrome / Q000209:etiology*
chemical_list: D000932:Antiemetics; D019344:Lactic Acid; D003907:Dexamethasone