The effects of rutaecarpine on the pharmacokinetics of acetaminophen in rats.
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study. When 25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the area under the curve of APAP in plasma was significantly decreased when compared to that of APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3 days, the % value of C(max) and area under the curve of acetaminophen-sulfate conjugate were significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of APAP in rats.
Lee
Sang Kyu
SK
College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea.
Bista
Sudeep R
SR
Jeong
Hemin
H
Kim
Dong Hyeon
DH
Kang
Mi Jeong
MJ
Jahng
Yurngdong
Y
Jeong
Tae Cheon
TC
D000082:Acetaminophen / Q000493:pharmacokinetics*; D000818:Animals; D019388:Cytochrome P-450 CYP1A2 / Q000096:biosynthesis; D003580:Cytochromes; D004347:Drug Interactions; D026121:Indole Alkaloids / Q000494:pharmacology*; D008297:Male; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D052999:Quinazolinones
D000082:Acetaminophen; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes; D026121:Indole Alkaloids; D011799:Quinazolines; C028632:rutecarpine; D052999:Quinazolinones; C017170:Cyp1a2 protein, rat