Preoperative identification of subthalamic nucleus for deep brain stimulation using three-dimensional phase sensitive inversion recovery technique.
OBJECTIVE
We assessed the feasibility of utilizing three-dimensional (3D) phase sensitive inversion recovery (IR) images for preoperatively determining deep brain stimulator position.


METHODS
We measured geometric distortion with a grid phantom and evaluated images of 3 volunteers to determine optimum imaging parameters for 3D phase sensitive IR.


RESULTS
Geometric distortion measured less than 1.0%. Respective inversion and recovery times, which provided high T(1) contrast between the subthalamic nucleus and adjacent tissue, were 200 and 4000 ms. In studies of 3 volunteers and 2 patients, the subthalamic nucleus was clearly depicted in 3D phase sensitive IR images. The measured coordinates of the subthalamic nucleus agreed well with those calculated by conventional estimation from midpoint of the anterior and posterior commissure.


CONCLUSIONS
Three-dimensional phase sensitive inversion recovery was useful in visualizing the subthalamic nucleus for effective deep brain stimulation.
Ishimori
Takashi
T
Department of Radiology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa, Japan. ishimori@med.kagawa-u.ac.jp
Nakano
Satoru
S
Mori
Yasutane
Y
Seo
Reiko
R
Togami
Taro
T
Masada
Tetsuya
T
Kusuhara
Toshiaki
T
Ohkawa
Motoomi
M
Nagao
Seigo
S
Yamashita
Yuichi
Y
Sugiura
Satoshi
S
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy; D019047:Phantoms, Imaging; D020531:Subthalamic Nucleus / Q000033:anatomy & histology* / Q000601:surgery*