title: Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection.
abstract: Lyme borreliae naturally maintain numerous distinct DNA elements of the cp32 family, each of which carries a mono- or bicistronic erp locus. The encoded Erp proteins are surface-exposed outer membrane lipoproteins that are produced at high levels during mammalian infection but largely repressed during colonization of vector ticks. Recent studies have revealed that some Erp proteins can serve as bacterial adhesins, binding host proteins such as the complement regulator factor H and the extracellular matrix component laminin. These results suggest that Erp proteins play roles in multiple aspects of mammalian infection.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, College of Medicine, MS 421 Chandler Medical Center, Lexington, KY 40536-0298, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Brissette
authors.forename: Anne E
authors.initials: AE
authors.lastname: Cooley
authors.forename: Logan H
authors.initials: LH
authors.lastname: Burns
authors.forename: Sean P
authors.initials: SP
authors.lastname: Riley
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Verma
authors.forename: Michael E
authors.initials: ME
authors.lastname: Woodman
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bykowski
authors.forename: Brian
authors.initials: B
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D025065:Borrelia burgdorferi / Q000378:metabolism / Q000472:pathogenicity*; D017242:Complement Factor H / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D008024:Ligands; D008074:Lipoproteins / Q000378:metabolism*; D008193:Lyme Disease / Q000382:microbiology
chemical_list: D001425:Bacterial Outer Membrane Proteins; D007797:Laminin; D008024:Ligands; D008074:Lipoproteins; D017242:Complement Factor H