Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH.
Three new sesquiterpene lactones, (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide (1), (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide (2) and 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1-5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.
Tabopda
Turibio Kuiate
TK
Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun. ttabopda@yahoo.fr
Ngoupayo
Joseph
J
Liu
Jiawei
J
Shaiq Ali
Muhammad
M
Khan
Shamsun Nahar
SN
Ngadjui
Bonaventure Tchaleu
BT
Luu
Bang
B
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004396:Coloring Agents; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012235:Rhodamines; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
C527318:(4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide; C527319:(4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide; C527320:2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide; D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D007783:Lactones; D012235:Rhodamines; D012717:Sesquiterpenes; C022027:lissamine rhodamine B