title: Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi).
abstract: Chemical studies on the roots of Fraxinus rhynchophylla led to the isolation of fraxisecoside (1), a novel coumarin-secoiridoid hybrid glycoside, namely, fraxetin-8-O-[11'-methyl-oleosidyl-(7'-->6'')]-beta-D-glucopyranoside and 14 known compounds. Their structures were elucidated based on chemical evidence and spectroscopic analysis, including extensive 2D NMR methods. Compound 2 was first isolated as a pure compound. Compound 1 exhibited moderate PTP1B inhibition activity. Compounds 1 and 2 showed inhibition activity against B- and T-cell proliferation, without cytotoxicity.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xiao
authors.forename: Qing-Hong
authors.initials: QH
authors.lastname: Song
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Zhang
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D003374:Coumarins / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D031661:Fraxinus / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D039823:Iridoids; C531099:fraxisecoside; C494415:qinpi; D014867:Water