Di(2-ethylhexyl) phthalate exposure during cardiopulmonary bypass.
Di(2-ethylhexyl) phthalate is an excellent plasticizer for polyvinyl chloride but a known endocrine disrupting chemical. To investigate whether tubing containing no diethylhexyl phthalate reduces the overall extraction of this plasticizer during cardiopulmonary bypass, 16 patients undergoing coronary artery bypass grafting were randomly divided into 2 groups of 8 each. Group A had tubing containing diethylhexyl phthalate in the circuit, and group B had no diethylhexyl phthalate in the tubing. The plasma diethylhexyl phthalate level at the end of cardiopulmonary bypass was significantly increased compared to before anesthesia in both groups (group A: 103 +/- 60 to 2,094 +/- 1,046 ng x mL(-1); group B: 135 +/- 60 to 472 +/- 141 ng x mL(-1)), and it was significantly higher in group A than group B. This study demonstrates that using tubing free from diethylhexyl phthalate significantly reduces the release of this agent during cardiopulmonary bypass, which may minimize exposure to diethylhexyl phthalate.
Takahashi
Yosuke
Y
Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Osaka 545-8585, Japan. ysk@msic.med.osaka-cu.ac.jp
Shibata
Toshihiko
T
Sasaki
Yasuyuki
Y
Fujii
Hiromichi
H
Bito
Yasuyuki
Y
Suehiro
Shigefumi
S
D000368:Aged; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D001026:Coronary Artery Bypass; D004051:Diethylhexyl Phthalate / Q000009:adverse effects / Q000097:blood*; D052244:Endocrine Disruptors / Q000009:adverse effects / Q000097:blood*; D004867:Equipment Design; D006801:Humans; D008297:Male; D008875:Middle Aged; D010968:Plasticizers / Q000009:adverse effects / Q000378:metabolism*; D011446:Prospective Studies; D018570:Risk Assessment; D015854:Up-Regulation
D052244:Endocrine Disruptors; D010968:Plasticizers; D004051:Diethylhexyl Phthalate