Cup-like acute myeloid leukemia: new disease or artificial phenomenon?
We investigated cup-like nuclear morphology of acute myeloid leukemia blasts in 266 randomly selected patients and its association with hematologic findings, disease markers and outcome data. Cup-like acute myeloid leukemia was diagnosed in 55 patients (21%). It was associated with female sex, high white blood cell and blast cell counts, normal karyotype, and low CD34 and HLA-DR expression. Mutations of FLT3, NPM1 or both were detected in 84.9% compared with 58.1% in cases without this morphology (p=0.001). There was no influence on response to treatment or survival. Therefore, cup-like nuclear morphology is an indicator of normal karyotype and should guide more specific molecular analyses.
Kroschinsky
Frank P
FP
First Medical Department, Dresden University Hospital, Dresden, Germany. kroschinsky@mk1.med.tu-dresden.de
Schäkel
Ulrike
U
Fischer
Rainer
R
Mohr
Brigitte
B
Oelschlaegel
Uta
U
Repp
Roland
R
Schaich
Markus
M
Soucek
Silke
S
Baretton
Gustavo
G
Ehninger
Gerhard
G
Thiede
Christian
C
D000328:Adult; D018952:Antigens, CD34 / Q000096:biosynthesis / Q000235:genetics; D001752:Blast Crisis / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics; D006684:HLA-DR Antigens / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics; D000090243:Nucleophosmin; D011897:Random Allocation; D012737:Sex Factors; D051941:fms-Like Tyrosine Kinase 3 / Q000096:biosynthesis / Q000235:genetics
D018952:Antigens, CD34; D006684:HLA-DR Antigens; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3