Pyrazinamide induced hyperuricaemia presenting as severe bilateral leg cramps.
Pyrazinamide is one of the first line drugs used for the treatment of tuberculosis. Hepatotoxicity and hyperuricaemia are important and common untoward effects seen after administration of pyrazinamide. The drug inhibits elimination of urates resulting in hyperuricaemia, the presenting features of which are arthralgia, arthritis or even gout. A-case of bilateral leg cramps due to hyperuricaemia following pyrazinamide therapy is reported here.
Gupta
Seema
S
Postgraduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu.
Gupta
Vikram
V
Kapoor
B
B
Kapoor
V
V
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D033461:Hyperuricemia / Q000139:chemically induced*; D008297:Male; D009120:Muscle Cramp / Q000139:chemically induced* / Q000175:diagnosis; D011718:Pyrazinamide / Q000009:adverse effects*
D000995:Antitubercular Agents; D011718:Pyrazinamide