title: Stem cells: an overview.
abstract: Stem cells are specialized cells that possess a capacity to undergo self-renewal while at the same time having the ability to give rise to at least one or more differentiated or mature cell type. They therefore represent a fundamental cornerstone during the life of all vertebrates, playing central roles in the production of new and replacement cells for tissues during development and homeostasis, including repair following disease or injury. This unit is a review of stem cells, their roles in development, and their potentials as therapeutic agents.
authors.affiliation: Monash University, Melbourne, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Denham
authors.forename: Brock
authors.initials: B
authors.lastname: Conley
authors.forename: Fredrik
authors.initials: F
authors.lastname: Olsson
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Cole
authors.forename: Richard
authors.initials: R
authors.lastname: Mollard
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics; D018390:Gene Targeting / Q000379:methods / Q000639:trends; D006801:Humans; D012038:Regeneration / Q000235:genetics*; D033581:Stem Cell Transplantation / Q000941:ethics / Q000379:methods / Q000639:trends; D013234:Stem Cells / Q000502:physiology*; D019098:Telomerase / Q000235:genetics
chemical_list: D019098:Telomerase