Overview of the cell cycle.
Progression through the cell cycle is regulated by inductive signals from outside the cell and intracellular signal pathways, while the cycle itself is regulated by cyclin-dependent kinases (CDKs). An understanding of the functions of these molecules is necessary to understand the processes of mitosis, differentiation, senescence, apoptosis, and tumorigenesis. This overview reviews the current state of knowledge for the biology of the cell-cycle, the CDKs, the role of proteolysis, targets of the cell cycle machinery, and a paradigm of cell cycle analysis.
Park
M S
MS
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Koff
A
A
D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000166:cytology; D018816:Genes, cdc; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D016160:Retinoblastoma Protein / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology
D018797:Cell Cycle Proteins; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016213:Cyclins; D016160:Retinoblastoma Protein; D025801:Ubiquitin; D018844:Cyclin-Dependent Kinases; D046988:Proteasome Endopeptidase Complex