Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers.
This study was conducted to estimate the effects of kisspeptin-10 on blood concentrations of LH and GH in prepubertal dairy heifers. Heifers received a single injection of 1 mg kisspeptin-10 (n=5) or saline (n=5) intravenously, and serial blood samples were collected at 15-min intervals to analyze the response curves of both LH and GH after injection. Peak-shaped responses were observed for concentrations of LH and GH, and the peaks were observed at 27+/-3 and 75+/-9 min, respectively, after injection, only in heifers injected with kisspeptin-10. These data suggest various possible important links among kisspeptin, the reproductive axis, and also the somatotropic axis in prepubertal Holstein heifers.
Kadokawa
H
H
Department of Veterinary Medicine, Faculty of Agricultural Science, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, Japan. hiroya@yamaguchi-u.ac.jp
Matsui
M
M
Hayashi
K
K
Matsunaga
N
N
Kawashima
C
C
Shimizu
T
T
Kida
K
K
Miyamoto
A
A
D000375:Aging / Q000097:blood*; D000818:Animals; D002417:Cattle; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D059648:Kisspeptins; D007986:Luteinizing Hormone / Q000097:blood*; D009842:Oligopeptides / Q000008:administration & dosage* / Q000494:pharmacology; D009994:Osmolar Concentration; D013997:Time Factors
C106628:KISS1 protein, human; D059648:Kisspeptins; D009842:Oligopeptides; D007986:Luteinizing Hormone; D013006:Growth Hormone