title: Extract of Pelargonium sidoides (EPs 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions.
abstract: EPs 7630 is an aqueous-ethanolic extract of the roots of PELARGONIUM SIDOIDES that displays well-documented benefits in the treatment of upper respiratory tract infections (URTI). IN VITRO and animal investigations have revealed various anti-infective properties of EPs 7630. The present review sums up recently published IN VITRO investigations that have shown positive effects on the activity of human peripheral blood phagocytes (PBP) and differential modulation of the interactions between group A streptococci and the host's epithelial barrier.
authors.affiliation: Institute of Environmental Medicine and Hospital Epidemiology, University Medical Center Freiburg, Freiburg, Germany. andreas.conrad@uniklinik-freiburg.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Conrad
authors.forename: Uwe
authors.initials: U
authors.lastname: Frank
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D054884:Host-Pathogen Interactions / Q000187:drug effects*; D006801:Humans; D031316:Pelargonium; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000276:immunology
chemical_list: D000890:Anti-Infective Agents; C476332:EPs 7630; D010936:Plant Extracts