title: Pseudomyxoma peritonei: a rare presentation as an umbilical nodule.
abstract: BACKGROUND
  Umbilical nodules are rare and may be the sole presenting sign of an advanced intra-abdominal malignancy associated with poor prognosis. Metastatic involvement of umbilicus was first described in 1846 by Sister Mary Joseph, who established the correlation between carcinomas and umbilical nodes.
  
  
  OBJECTIVE
  We aim to describe a case report of Pseudo Myxoma Peritonei in a 31-year-old man who presented with subcutaneous non tender umbilical nodule. We also aim to emphasize the importance of differential diagnosis, when one encounters the presence of mucoid material in unusual sites such as the umbilicus.
  
  
  METHODS
  Patient's clinical notes, operative findings, imaging studies, laboratory investigations including histopathology and immunohistochemistry were reviewed. A literature search was done to look into the incidence, pathophysiology, presentation and treatment options for this neoplastic process.
  
  
  CONCLUSIONS
  PMP should be considered as one of the differential diagnosis when one encounters mucinous collection in unusual sites such as the umbilicus.
authors.affiliation: Department of General Surgery, North Tyneside General Hospital, Rake Lane, North Shields, NE29 8NH, UK. simha_anu@yahoo.com
authors.forename: N
authors.initials: N
authors.lastname: Srinivasaiah
authors.forename: G
authors.initials: G
authors.lastname: Retnasingam
authors.forename: R
authors.initials: R
authors.lastname: Kasarneni
authors.forename: B
authors.initials: B
authors.lastname: Slater
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009077:Mucins; D011379:Prognosis; D011553:Pseudomyxoma Peritonei / Q000175:diagnosis* / Q000601:surgery; D014472:Umbilicus
chemical_list: D009077:Mucins