title: Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose.
abstract: Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine), bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is a time-dependent reversible process. The equilibrium is attained within 2.5-8.0 h and depends on the chemical nature of local anesthetic.
authors.affiliation: Krasnodar Affiliated Department of Southern Bureau of Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Galenko-Yaroshevskii
authors.forename: I A
authors.initials: IA
authors.lastname: Varlashkina
authors.forename: Kh P
authors.initials: KhP
authors.lastname: Takhchidi
authors.forename: B E
authors.initials: BE
authors.lastname: Malyugin
authors.forename: A S
authors.initials: AS
authors.lastname: Dukhanin
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry*; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008968:Molecular Conformation; D012996:Solutions; D014867:Water
chemical_list: D000779:Anesthetics, Local; D012996:Solutions; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose