title: Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study.
abstract: To clarify the clinical features of adult patients with acute leukemia (AL) with 11q23 abnormalities, we performed a retrospective analysis of data from 58 adult Japanese patients: 51 with acute myeloid leukemia (AML), and 7 with acute lymphoblastic leukemia (ALL). The incidences according to fusion partners in AML were: t(9;11), 31.3%; t(11;19), 27.4%; t(6;11), 21.5%. The incidence of patients with t(11;19) was higher than those in the US and Europe, and the incidence of t(4;11) was lower than that in childhood. The results indicated the poor prognosis of AML with 11q23 abnormalities regardless of the fusion partners. AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo-HSCT, although the differences were not statistically significant (P = 0.322 for DFS, P = 0.138 for OS). This result suggests that treatment strategies including allo-HSCT may be considered in the first CR in cases of AML with 11q23 abnormalities. However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities.
authors.affiliation: Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan. s6056@nms.ac.jp.
authors.forename: Hayato
authors.initials: H
authors.lastname: Tamai
authors.affiliation: Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamaguchi
authors.affiliation: Department of Hematology, Saitama Medical University, Saitama, Japan.
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Yagasaki
authors.affiliation: Department of Hematology, Saitama Medical University, Saitama, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Bessho
authors.affiliation: Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Akiyama
authors.affiliation: Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.affiliation: Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
authors.affiliation: Department of Hematology, Jichi Medical School, Tochigi, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmine
authors.affiliation: Department of Hematology, Jichi Medical School, Tochigi, Japan.
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
authors.affiliation: Department of Hematology, Kanazawa University, Ishikawa, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Okumura
authors.affiliation: Department of Hematology, Kanazawa University, Ishikawa, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
authors.affiliation: Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Arai
authors.affiliation: Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Miura
authors.affiliation: Department of Hematology, Yokosuka Kyosai Hospital, Kanagawa, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Toyota
authors.affiliation: Department of Hematology, Yokohama Minami Kyosai Hospital, Kanagawa, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Gomi
authors.affiliation: Department of Hematology, Tama Hokubu Medical Center, Tokyo, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Murai
authors.affiliation: Department of Hematology, The Jikei University, Tokyo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Usui
authors.affiliation: Department of Hematology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miyazawa
authors.affiliation: Department of Hematology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.affiliation: Department of Internal Medicine, Akita University, Akita, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Department of Internal Medicine, Akita University, Akita, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sawada
authors.affiliation: Department of Hematology, Juntendo University, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.affiliation: Department of Hematology, Juntendo University, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Oshimi
authors.affiliation: Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
authors.forename: Koiti
authors.initials: K
authors.lastname: Inokuchi
authors.affiliation: Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
mesh_terms: D000328:Adult; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000628:therapy; D012189:Retrospective Studies; D014178:Translocation, Genetic / Q000235:genetics*; D014184:Transplantation, Homologous