title: [Drugs in pregnancy].
abstract: The use of drugs in pregnancy is being discussed. The influence of different factors, both physiological and drug related (physicochemical characteristics, dose, duration of pharmacotherapy) on the processes of absorption, distribution, protein binding, metabolism and excretion are reviewed. The up-to-date classification of the drugs in relation to their effects on the fetus is presented. Special emphasize is given to drugs (antibiotics, cardio-vascular, psychotropic etc.) used for the treatment of acute and chronic conditions in the course of pregnancy. Drugs used for symptoms like pain, high temperature and constipation are also reviewed. Recommendations for the use of safer drugs in pregnancy are given. Drugs with proven teratogenic effects are presented.
authors.forename: N
authors.initials: N
authors.lastname: Danchev
authors.forename: A
authors.initials: A
authors.lastname: Astrug
authors.forename: V
authors.initials: V
authors.lastname: Tsankova
authors.forename: I
authors.initials: I
authors.lastname: Nikolova
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D064420:Drug-Related Side Effects and Adverse Reactions; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D008658:Inactivation, Metabolic; D004364:Pharmaceutical Preparations / Q000097:blood / Q000145:classification; D011247:Pregnancy
chemical_list: D004364:Pharmaceutical Preparations