title: Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue thickening in canine experimental stifle osteoarthritis: comparison between 1.5 T magnetic resonance imaging and computed radiography.
abstract: OBJECTIVE
  To compare use of 1.5 T magnetic resonance imaging (MRI) and computed radiography (CR) for morphologic and temporal evaluation of osteophytosis, subchondral sclerosis, joint effusion, and synovial thickening in experimentally induced canine stifle osteoarthritis (OA).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Dogs (n=8).
  
  
  METHODS
  CR (mediolateral and caudocranial projections) and MRI (dorsal 3D T1-weighted gradient echo, sagittal 3D SPGR and T2-weighted fast spin echo with fat saturation) were performed at baseline (n=8) and at week 4 (n=5), week 8 (n=8), and week 26 (n=5) after cranial cruciate ligament transection. Osteophytosis, subchondral bone sclerosis, and joint effusion were scored on CR and MRI, and synovial thickening on MRI.
  
  
  RESULTS
  MRI was more sensitive than CR for detection of osteophytosis and could better discriminate joint effusion from soft tissue thickening, although scores for these variables strongly correlated between modalities (rho=0.94 [osteophytosis] and 0.80 [effusion]; P<.001). Scores for subchondral bone sclerosis also correlated (rho=0.54, P<.004), although this variable may have been over interpreted on CR. Joint effusion and synovial thickening peaked at week 8, before partially regressing at week 26. Conversely, osteophytosis and sclerosis progressed semi-linearly over 26 weeks.
  
  
  CONCLUSIONS
  MRI is more sensitive than radiography in assessing onset and progression of osteophytosis in canine experimental stifle OA and provides enhanced discrimination between joint effusion and synovial thickening.
  
  
  CONCLUSIONS
  MRI is as a more powerful imaging modality that should be increasingly used in animals to assess the joint related effects of disease-modifying OA drugs.
authors.affiliation: Companion Animal Research Group, Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada. marc-andre.danjou@umontreal.ca
authors.forename: Marc-André
authors.initials: MA
authors.lastname: D'Anjou
authors.forename: Maxim
authors.initials: M
authors.lastname: Moreau
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.forename: François
authors.initials: F
authors.lastname: Abram
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Raynauld
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D020370:Osteoarthritis, Knee / Q000601:surgery / Q000662:veterinary*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013264:Stifle; D013583:Synovial Membrane / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000662:veterinary