Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species.
In pediatric bloodstream infections with fluoroquinolone (FQ)-resistant Escherichia coli and Klebsielia species, we noted an association between FQ resistance and extended-spectrum beta-lactamase (ESBL) production (OR, 12; 95% CI: 2.28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK).
Kim
Jason Y
JY
Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. kimj@email.chop.edu
Lautenbach
Ebbing
E
Chu
Jaclyn
J
Goyal
Monika
M
Nachamkin
Irving
I
McGowan
Karin
K
Coffin
Susan
S
Zaoutis
Theoklis
T
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D016022:Case-Control Studies; D002648:Child; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects* / Q000302:isolation & purification; D008297:Male; D012307:Risk Factors; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D001618:beta-Lactamases