Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats.
Comparative morphometrical study of the renal glomerular system was carried out in hypertensive NISAG rats treated with hypotensive drugs during the prepubertal period. Blockade of the renin-angiotensin system with enalapril or losartan during the critical period of ontogeny (the 2nd month of life) produced a long-term hypotensive and renoprotective effect. Treatment with alpha-adrenoblocker terazosin during this period of ontogeny produced a less pronounced hypotensive effect, though with renoprotection. Corinfar (Ca2+ channel blocker) was least effective.
Filyushina
E E
EE
Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. e.e.filjushina@iph.ma.nsc.ru
Shmerling
M D
MD
Lazarev
V A
VA
Buzuyeva
I I
II
Markel'
A L
AL
Yakobson
G S
GS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004656:Enalapril / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use; D011224:Prazosin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D000959:Antihypertensive Agents; D004656:Enalapril; C041226:Terazosin; D009543:Nifedipine; D019808:Losartan; D011224:Prazosin