title: Structure-activity relationship of triterpenes and triterpenoid glycosides against tobacco mosaic virus.
abstract: A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according to the results of bio-activity screening. Besides, the EC(50) values of those compounds having higher activities were measured.
authors.affiliation: Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China.
authors.forename: Zheng-Kun
authors.initials: ZK
authors.lastname: Zhang
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Ouyang
authors.forename: Zu-Jian
authors.initials: ZJ
authors.lastname: Wu
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Lin
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Xie
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D014315:Triterpenes