[The study of 99mTc-N(NOEt)2 imaging in experimental nasopharyngeal carcinoma mice models].
OBJECTIVE
To evaluate the validity of 99mTc-N(NOEt)2 imaging in nasopharyngeal carcinoma mice model compared with 99mTc-MIBI imaging.


METHODS
Biodistribution of 99mTc-N(NOEt)2 were performed on Kunmin mice. Nasopharyngeal carcinoma BALb/c nude mice models were replicated by subcutaneous injection of CNE cells. After intravenous injection of 99mTc-N(NOEt)2 or 99mTc-MIBI images were acquired with SPECT, regions of interesting (ROI) were drawn to evaluate the uptake of 99mTc-N(NOEt)2 or 99mTc-MIBI in tumor imaging. Tumor to non-tumor ratios (T/N) were used as index of evaluation.


RESULTS
Biodistribution study indicated most of 99mTc-N(NOEt)2 was accumulated in liver, kidney, lung and heart. The T/N values had no significant difference between 99mTc-N(NOEt)2 and 99mTc-MIBI at 30 min post injection. The peak T/N value of 99mTc-N(NOEt)2 reached at 120 min post injection. The best time for imaging was 120 min post injection. The T/N ratio was significantly higher in the group of 99mTc-N(NOEt)2 than that of 99mTc-MIBI at 120 min.


CONCLUSIONS
99mTc-N(NOEt)2 can be used for nasopharyngeal carcinoma mice model imaging. The best time of imaging is 120 min. 99mTc-N(NOEt)2 is a potential imaging agent for nasopharyngeal carcinoma.
Wang
Yanju
Y
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cao
Wei
W
Xie
Guihua
G
Sun
Yu
Y
Yang
Yang
Y
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D013859:Thiocarbamates; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013859:Thiocarbamates; D017256:Technetium Tc 99m Sestamibi; C093922:technetium Tc 99m, bis(N-ethoxy-N-ethyldithiocarbamato)nitrido-