Comparative prevalence of plasma human herpesvirus 8 DNA in sexual contact and intravenous injection routes of HIV transmission.
Detection of plasma human herpesvirus (HHV)-8 DNA correlates with antibodies to lytic HHV-8 antigens, being predictive of Kaposi's sarcoma in HIV-infected patients. We show that the prevalence of plasma HHV-8 DNA was 10.6% for HIV infection through sexual contact and 7.1% for HIV infection through intravenous injection. In addition, the prevalence of plasma HHV-8 DNA was significantly associated with male gender (9.4%) and HIV viral load below 1000 copies mL(-1) (12.1%), but not age or CD4 cell count in HIV-infected patients. The study suggested that detection of plasma HHV-8 DNA could be important for monitoring replicating HHV-8 in HIV-infected patients, and may have use as a marker for the diagnosis of HHV-8 infection in blood-borne transmission.
Lin
Cheng-Wen
CW
Department of Medical Laboratory Science and Biotechnology, China Medical University Hospital, Taichung, Taiwan. cwlin@mail.cmu.edu.tw
Chang
Chun-Pin
CP
Wu
Fang-Yang
FY
Liu
Chao-Li
CL
D017088:AIDS-Related Opportunistic Infections / Q000821:virology; D004279:DNA, Viral / Q000097:blood*; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007275:Injections, Intravenous; D010949:Plasma / Q000821:virology; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D012514:Sarcoma, Kaposi; D015229:Sexually Transmitted Diseases, Viral / Q000635:transmission* / Q000821:virology; D015819:Substance Abuse, Intravenous
D004279:DNA, Viral; D012367:RNA, Viral