Novel isocyanide-based three-component synthesis of 3,4-dihydroquinoxalin-2-amine derivatives.
Synthesis of a novel class of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives including spirocyclic compounds from three-component condensation reaction of o-phenylenediamines, diverse carbonyl compounds, and isocyanides in the presence of a catalytic amount of p-toluenesulfonic acid in good to excellent yields at room temperature is described.
Shaabani
Ahmad
A
Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran. ashaabani@cc.sbu.ac.ir
Maleki
Ali
A
Mofakham
Hamid
H
Khavasi
Hamid Reza
HR
D002855:Chromatography, Thin Layer; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D003486:Cyanides; D011810:Quinoxalines