[Study of dynamic changes of blood sugar and body signs in streptozotocin-induced diabetic animal models].
OBJECTIVE
To explore the dynamic changes of blood sugar and body's signs in streptozotocin diabetic animal models.


METHODS
Rat and mouse diabetic models were established by a single intraperitoneal (ip) injection and 5-day successive ip injections of streptozotocin respectively. Blood sugar levels were measured. The food consumption index (consumption of food/body weight) and the water consumption index (consumption of water/body weight) were calculated.


RESULTS
Sixty five point zero percent male rats received streptozotocin, 60 mg/kg ip, developed diabetes mellitus. The blood sugar remained in high level between the 15th day and the 25th day after injection, and it began to decline afterwards. By 5-day ip injections of streptozotocin, 40 mg/kg daily, 90.0% male mice developed diabetes mellitus. Dynamic changes of blood sugar of diabetic mouse were similar to those of rats, except that the blood sugar of mice did not decline as obvious as that of rats. The changes of water consumption index were in best fit with the changes of blood sugar in both models, with correlation index r>0.970.


CONCLUSIONS
The blood sugar of diabetic animal model stayed in high level from the 15th day to the 25th day after the beginning of injection. And the period is suitable for observing effect of anti-diabetic drugs. The water consumption index can reflect the blood sugar levels of diabetes animals.
Yu
Chuan-Lin
CL
Pharmaceutical Institute of Pharmaceutical School, Southern Medical University, Guangzhou 510515, China.
Zhu
Zheng-Guang
ZG
Lei
Lin-Sheng
LS
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology*; D004195:Disease Models, Animal; D004326:Drinking / Q000502:physiology; D004435:Eating / Q000502:physiology; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D013311:Streptozocin