NT-proBNP levels and resting hemodynamic parameters assessed by bioimpedance in patients with chronic heart failure.
OBJECTIVE
To evaluate whether NT-proBNP levels are associated with resting hemodynamic parameters assessed by thoracic electrical bioimpedance (TEB) in patients with chronic heart failure (CHF).


METHODS
We studied 55 consecutive patients with dilated cardiomyopathy and CHF--42 male, aged 50.3 +/- 13.5 years, 39% ischemic, 36% in NYHA functional class III and 9% in class IV, left ventricular ejection fraction 24.7 +/- 8.2%, 85% in sinus rhythm. After 15 minutes of rest, NT-proBNP was obtained and TEB studies were performed (BioZ ICG Monitor, CardioDynamics; mean of 20 minutes acquisition). Thoracic fluid content (TFC) is a TEB parameter that shows a good correlation with pulmonary capillary wedge pressure.


RESULTS
NT-proBNP levels ranged from 42 to 12983 pg/ml (mean = 2505.8, SD = 2608.0, median = 1545). The correlations obtained presented in the table.


CONCLUSIONS
In patients with CHF resting NT-proBNP levels correlate with SVI, LCWI and TFC assessed by TEB, the strongest correlation being with TFC.
Feliciano
Joana
J
Servigo de Cardiologia Hospital de Santa Marta, Lisboa, Portugal. joanafeliciano@netcabo.pt
Soares
Rui
R
Silva
Sofia
S
Fiarresga
António
A
Fernandes
Rita Marfn
RM
Miranda
Fernando
F
Ferreira
Rui Cruz
RC
D002908:Chronic Disease; D017097:Electric Impedance; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain