title: Inhibitory effects of hypertonic saline on P. aeruginosa motility.
abstract: Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States. Electronic address: vhavasi@uab.edu.
authors.forename: Viktória
authors.initials: V
authors.lastname: Havasi
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.
authors.forename: Casey O
authors.initials: CO
authors.lastname: Hurst
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.
authors.forename: Travis C
authors.initials: TC
authors.lastname: Briles
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.
authors.forename: David G
authors.initials: DG
authors.lastname: Bains
authors.affiliation: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, United States.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Hassett
authors.affiliation: Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.
authors.forename: Eric
authors.initials: E
authors.lastname: Sorscher
mesh_terms: D000280:Administration, Inhalation; D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D005407:Flagella / Q000187:drug effects*; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D012141:Respiratory Tract Infections / Q000150:complications / Q000517:prevention & control; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D012462:Saline Solution, Hypertonic