Hereditary etiologies of hypomagnesemia.
Magnesium ions are essential to all living cells. As the second most abundant intracellular cation, magnesium has a crucial role in fundamental metabolic processes such as DNA and protein synthesis, oxidative phosphorylation, enzyme function, ion channel regulation, and neuromuscular excitability. After presenting an overview of magnesium homeostasis, we review the etiologies of hypomagnesemia, with an emphasis on hereditary causes.
Naderi
Amir Said Alizadeh
AS
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-8837, USA. anader@parknet.pmh.org
Reilly
Robert F
RF
D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000209:etiology / Q000503:physiopathology; D004502:Education, Medical, Continuing; D005260:Female; D020022:Genetic Predisposition to Disease; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D006996:Hypocalcemia / Q000097:blood / Q000175:diagnosis*; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000097:blood / Q000235:genetics*; D008297:Male; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases; D018570:Risk Assessment; D050053:TRPM Cation Channels / Q000235:genetics* / Q000378:metabolism
D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D008274:Magnesium