GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover.
In this issue of Molecular Cell, Vlasova et al. (2008) identify the GU-rich element (GRE) as a novel, widespread, degradation-promoting sequence through which the RNA-binding protein CUGBP1 elicits mRNA decay.
Kim
Hyeon Ho
HH
Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Gorospe
Myriam
M
D020413:3' Untranslated Regions / Q000235:genetics / Q000378:metabolism*; D000067879:CELF1 Protein; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D005914:Globins / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism; D020871:RNA Stability / Q000502:physiology*; D034741:RNA, Small Interfering / Q000235:genetics; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
D020413:3' Untranslated Regions; D000067879:CELF1 Protein; C102843:CELF1 protein, human; D016755:Proto-Oncogene Proteins c-jun; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; D018124:Receptors, Tumor Necrosis Factor; D005914:Globins