title: Chemotherapy of leishmaniasis part-VIII: synthesis and bioevaluation of novel chalcones.
abstract: Some novel dihydro-alpha-ionone based chalcones have been synthesized and evaluated for their in vitro antileishmanial activity in promastigote and amastigote model. Some of the compounds showed 100% inhibition at 5 and 2 microm/ml concentration.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, India. shivajins@yahoo.co.in
authors.forename: S N
authors.initials: SN
authors.lastname: Suryawanshi
authors.forename: Naveen
authors.initials: N
authors.lastname: Chandra
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.forename: Jyoti
authors.initials: J
authors.lastname: Porwal
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007893:Leishmania donovani / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D047188:Chalcones