Stressed out: the skeletal muscle ryanodine receptor as a target of stress.
Over the past century, understanding the mechanisms underlying muscle fatigue and weakness has been the focus of much investigation. However, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to tell the whole story. Recently, dysregulation of sarcoplasmic reticulum (SR) Ca(2+) release has been associated with impaired muscle function induced by a wide range of stressors, from dystrophy to heart failure to muscle fatigue. Here, we address current understandings of the altered regulation of SR Ca(2+) release during chronic stress, focusing on the role of the SR Ca(2+) release channel known as the type 1 ryanodine receptor.
Bellinger
Andrew M
AM
Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Mongillo
Marco
M
Marks
Andrew R
AR
D000818:Animals; D002118:Calcium / Q000378:metabolism; D017079:Exercise Tolerance; D006801:Humans; D008305:Malignant Hyperthermia / Q000235:genetics*; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000188:drug therapy / Q000235:genetics*; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013314:Stress, Mechanical
D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium