The effect of sibutramine intake on resting and exercise physiological responses.
OBJECTIVE
To evaluate the effect of a short-term sibutramine intake on energy expenditure and on physiological responses during rest, submaximal exercise and maximal exercise in obese women.


METHODS
Fifteen healthy obese female volunteers were randomly assigned to either a placebo (n = 6 - control) or sibutramine group (n = 9 - experimental) under double-blind conditions. Each subject was tested under resting conditions and then performed submaximal and maximal exercise tests. Subjects were retested under identical conditions following a 5-day administration of either sibutramine 10 mg x day(-1) or a placebo. All measurements (i.e. weight, body composition, resting energy expenditure, heart rate, respiratory exchange ratio, ventilation, oxygen consumption, carbon dioxide production, systolic blood pressure, diastolic blood pressure and blood lactate concentration) were analyzed using a 2-way ANOVA with repeated measures.


RESULTS
Only heart rate during submaximal exercise was significantly different (higher) following short-term sibutramine administration when compared to placebo (p < 0.05).


CONCLUSIONS
These data suggest that a recommended daily dose of 10 mg sibutramine does not affect energy expenditure or other selected cardiopulmonary responses during rest, submaximal exercise or maximal exercise. It is, therefore, suggested that weight loss during sibutramine treatment in humans is achieved mostly via a decrease in energy intake rather than through an increase in energy expenditure and thermogenesis.
Rotstein
Arie
A
Department of Life Sciences, Zinman College, Wingate Institute, Netanya, Israel.
Inbar
Omri
O
Vaisman
Nachum
N
D000328:Adult; D000704:Analysis of Variance; D001067:Appetite Depressants / Q000494:pharmacology*; D001481:Basal Metabolism / Q000187:drug effects* / Q000502:physiology; D015992:Body Mass Index; D003503:Cyclobutanes / Q000494:pharmacology*; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects* / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine