title: Review of methodological developments in laser Doppler flowmetry.
abstract: Laser Doppler flowmetry is a non-invasive method of measuring microcirculatory blood flow in tissue. In this review the technique is discussed in detail. The theoretical and experimental developments to improve the technique are reviewed. The limitations of the method are elaborated upon, and the research done so far to overcome these limitations is critically assessed.
authors.affiliation: Institute of Biomedical Technology, Biophysical Engineering Group, University of Twente, P.O. Box 217, 7500AE, Enschede, The Netherlands. v.rajan@tnw.utwente.nl
authors.forename: Vinayakrishnan
authors.initials: V
authors.lastname: Rajan
authors.forename: Babu
authors.initials: B
authors.lastname: Varghese
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
authors.forename: Wiendelt
authors.initials: W
authors.lastname: Steenbergen
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation / Q000379:methods*; D054023:Lasers, Semiconductor; D008833:Microcirculation / Q000502:physiology*; D012542:Scattering, Radiation