Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma.
FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MAL andT1 BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.
Adam
Patrick
P
Haralambieva
Eugenia
E
Hartmann
Martina
M
Mao
Zhengrong
Z
Ott
German
G
Rosenwald
Andreas
A
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D017403:In Situ Hybridization; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics*; D008297:Male; D040641:Quantitative Trait Loci / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D012189:Retrospective Studies; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D012097:Repressor Proteins