Copper-catalyzed synthesis of enantioenriched tetraarylethanes.
Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.
Jen
Wendy S
WS
Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wendy_jen@merck.com
Truppo
Matthew D
MD
Amos
Deborah
D
Devine
Paul
P
McNevin
Michael
M
Biba
Mirlinda
M
Campos
Kevin R
KR
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004980:Ethane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D006842:Hydrocarbons, Brominated; D003300:Copper; D004980:Ethane