title: A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling.
abstract: Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Suenaga
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Hatsushika
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takano
authors.forename: Takashi
authors.initials: T
authors.lastname: Ando
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohnuma
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Nakao
mesh_terms: D019898:Autocrine Communication / Q000187:drug effects; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D051900:Smad3 Protein / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D053781:Transforming Growth Factor beta2 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen; D051900:Smad3 Protein; D013267:Stilbenes; D053781:Transforming Growth Factor beta2; D000077185:Resveratrol