Theory and generalization of Monte Carlo models of the BOLD signal source.
The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics.
Martindale
John
J
Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Sheffield, UK.
Kennerley
Aneurin J
AJ
Johnston
David
D
Zheng
Ying
Y
Mayhew
John E
JE
D006439:Hemodynamics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009010:Monte Carlo Method; D010100:Oxygen / Q000097:blood*; D019047:Phantoms, Imaging
D010100:Oxygen