Fast generic chiral separation strategies using electrophoretic and liquid chromatographic techniques.
Because of the large number of commercially available chiral selectors both for electrophoretic and chromatographic techniques, the experimental possibilities to separate enantiomers are numerous. As a result, the development of a proper separation method for a chiral molecule is challenging. Generic separation strategies can present a useful approach for chiral method development. This paper overviews some strategies that have been developed earlier for different electrophoretic and chromatographic techniques. These strategies can be used either for impurity determination of enantiomers or for the enantioseparation of racemic mixtures. They are not only generic, i.e. applicable on diverse molecules, but are also fast, i.e. requiring only a limited number of experiments to reach a decision.
Ates
Hasret
H
Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel-VUB, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Mangelings
Debby
D
Vander Heyden
Yvan
Y
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013237:Stereoisomerism