title: The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells.
abstract: The knockdown of PR-B by siRNA resulted in a significant increase in proliferation in an immortalized endometrial stromal cell line. This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis.
authors.affiliation: Taussig Cancer Center, Center for Hematology and Oncology Molecular Therapeutics, Cleveland, Ohio, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Xuerong
authors.initials: X
authors.lastname: Shi
authors.forename: Sun-Wei
authors.initials: SW
authors.lastname: Guo
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation; D004717:Endometrium / Q000166:cytology* / Q000502:physiology*; D005260:Female; D020868:Gene Silencing / Q000502:physiology; D006801:Humans; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology
chemical_list: D011980:Receptors, Progesterone; C097314:progesterone receptor B