Reduced sensitivity of influenza A (H5N1) to oseltamivir.
We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.
McKimm-Breschkin
Jennifer L
JL
CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia. jennifer.mckimm-breschkin@csiro.au
Selleck
Paul W
PW
Usman
Tri Bhakti
TB
Johnson
Michael A
MA
D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D053139:Oseltamivir / Q000494:pharmacology*; D012794:Sialic Acids / Q000494:pharmacology; D053243:Zanamivir / Q000494:pharmacology
D000998:Antiviral Agents; D012794:Sialic Acids; C081427:4-amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid; D053139:Oseltamivir; D053243:Zanamivir