Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones.
A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramolecular N-arylation and an intermolecular Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones 3. The starting materials were synthesized by the Ugi four-component reaction. An unprecedented X-ray structure of bispalladacycle 6 was documented.
Salcedo
Angela
A
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.
Neuville
Luc
L
Rondot
Christophe
C
Retailleau
Pascal
P
Zhu
Jieping
J
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D001569:Benzodiazepines; D010165:Palladium