Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension.
We studied the effects of antioxidants resveratrol and pQ510 on physiological parameters and the state of endothelial NO-synthase as a marker of the regulatory function of the endothelium in the aorta of rats with modeled arterial hypertension. The antioxidants promoted recovery of stable NO metabolites in rat serum and maintained expression of endothelial NO-synthase at a normal level. These effects were confirmed by correction of blood pressure and endothelium-dependent vascular dilation assessed by endothelial dysfunction coefficient.
Gumanova
N G
NG
State Research Institute of Preventive Medicine, Ministry of Health of the Russian Federation, Moscow.
Artyushkova
E B
EB
Metel'skaya
V A
VA
Kochkarov
V I
VI
Pokrovskaya
T G
TG
Danilenko
L M
LM
Korneev
M M
MM
Pokrovskii
M V
MV
Pashin
E N
EN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000975:Antioxidants; D009942:Organometallic Compounds; D013267:Stilbenes; C526652:pQ510 compound; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D001205:Ascorbic Acid; D000077185:Resveratrol; D019331:NG-Nitroarginine Methyl Ester