title: [Association of PPARD gene polymorphism with human physical performance].
abstract: Peroxisome proliferator-activated receptor delta (PPARdelta) regulates expression of genes involved in lipid and carbohydrate metabolism. To examine the association of a functional +294T/C polymorphism of PPARD gene with human physical performance, we have studied the distribution of PPARD alleles and genotypes in a cohort of athletes (n=1256; stratified by specialty and skill level) and controls (n=610). We found that the frequency of PPARD C allele (with higher transcriptional activity compared to T allele) in a group of endurance-oriented athletes (n=898) is significantly higher than in controls (18.3% vs. 12.1%; p < 0.0001). Moreover, in the group of endurance-oriented athletes with cyclic activity we revealed an increasing frequency of PPARD C allele with the rising of athletes' skill level. Thus, PPARD C allele is associated with predisposition to endurance performance.
authors.forename: I I
authors.initials: II
authors.lastname: Akhmetov
authors.forename: I V
authors.initials: IV
authors.lastname: Astranenkova
authors.forename: V A
authors.initials: VA
authors.lastname: Rogozkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D050260:Carbohydrate Metabolism / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D047494:PPAR delta / Q000235:genetics* / Q000378:metabolism; D010807:Physical Endurance / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D047494:PPAR delta