title: The UGT2B17 gene deletion is not associated with prostate cancer risk.
abstract: BACKGROUND
  Deletion polymorphism of the UDP-glucuronosyltransferase 2B17 (UGT2B17) gene has been associated with an increased prostate cancer risk in two previous independent studies. Here we determine the risk in a large-scale population-based case-control study.
  
  
  METHODS
  Genotyping was conducted with a 5'-nuclease activity assay to distinguish those with one or two UGT2B17 gene copies (ins/del and ins/ins) from individuals homozygous for the deletion (del/del) allele.
  
  
  RESULTS
  In contrast to previous findings, no association between the UGT2B17 deletion polymorphism and prostate cancer risk was found. Furthermore the UGT2B17 gene deletion did not affect the risk for prostate cancer specific death.
  
  
  CONCLUSIONS
  The UGT2B17 deletion polymorphism does not play a major role in prostate cancer susceptibility as previously indicated.
authors.affiliation: Department of Urology, Karolinska University Hospital, Stockholm, Sweden. mats.j.olsson@karlolinska.se
authors.forename: Mats
authors.initials: M
authors.lastname: Olsson
authors.forename: Sara
authors.initials: S
authors.lastname: Lindström
authors.forename: Benjamin
authors.initials: B
authors.lastname: Häggkvist
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.forename: Katarina
authors.initials: K
authors.lastname: Bälter
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Birgitta
authors.initials: B
authors.lastname: Ask
authors.forename: Anders
authors.initials: A
authors.lastname: Rane
authors.forename: Lena
authors.initials: L
authors.lastname: Ekström
authors.forename: Henrik
authors.initials: H
authors.lastname: Grönberg
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D011110:Polymorphism, Genetic / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D013548:Sweden
chemical_list: D015778:Minor Histocompatibility Antigens; D014453:Glucuronosyltransferase; C500513:UGT2B17 protein, human