title: Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.
abstract: To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function.
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Fyodor N
authors.initials: FN
authors.lastname: Zolotaryov
authors.forename: Kyoung Su
authors.initials: KS
authors.lastname: Hong
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Keiji
authors.initials: K
authors.lastname: Iida
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okimura
authors.forename: Hidesuke
authors.initials: H
authors.lastname: Kaji
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chihara
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000918:Antibody Specificity / Q000187:drug effects; D019556:COS Cells; D002454:Cell Differentiation / Q000187:drug effects; D018925:Chemokines; D002630:Chemotactic Factors / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D003470:Culture Media; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D018925:Chemokines; D002630:Chemotactic Factors; D003470:Culture Media; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C523686:chemerin protein, mouse; D005947:Glucose