title: Urinary IL-18: a marker of contrast-induced nephropathy following percutaneous coronary intervention?
abstract: OBJECTIVE
  Contrast-induced nephropathy (CIN) is a complication that is underestimated in clinical practice after cardiac catheterization. Recently, the value of interleukin (IL)-18 as a novel biomarker for the detection of acute renal failure has been highlighted. In the present study, we sought to investigate whether urine IL-18 may be an early diagnostic marker of CIN.
  
  
  METHODS
  We performed a nested case-control study using a hospital based cohort of all patients (n=157) admitted for elective PCI for stable angina to the Uludag University School of Medicine between February 2007 and June 2007. We identified 15 patients (9.5%) with CIN. Controls were matched with cases at an attempted 2.5:1 ratio by age and gender. Urinary IL-18 values were measured before as well as 24 and 72 h after the PCI.
  
  
  RESULTS
  No statistically significant differences in urine IL-18 were detected between cases (n=15) and controls (n=36) or between the patient samples obtained before PCI and after the invasive procedure in both study groups.
  
  
  CONCLUSIONS
  These findings argue against the hypothesis that urine IL-18 may be clinically useful as a biomarker of CIN after radiological procedures requiring intravascular administration of iodinated contrast media. Further studies with larger sample sizes are needed to validate our findings.
authors.affiliation: Department of Internal Medicine, Uludag University Medical School, Bursa, 16059 Turkey. cumabulentgul@uludag.edu.tr
authors.forename: Cuma Bulent
authors.initials: CB
authors.lastname: Bulent Gul
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gullulu
authors.forename: Barboros
authors.initials: B
authors.lastname: Oral
authors.forename: Ali
authors.initials: A
authors.lastname: Aydinlar
authors.forename: Ozen
authors.initials: O
authors.lastname: Oz
authors.forename: Ferah
authors.initials: F
authors.lastname: Budak
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yurtkuran
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000652:urine*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D020382:Interleukin-18