A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling.
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.
Suenaga
Fumiko
F
Department of Immunology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Hatsushika
Kyosuke
K
Takano
Shinichi
S
Ando
Takashi
T
Ohnuma
Yuko
Y
Ogawa
Hideoki
H
Nakao
Atsuhito
A
D019898:Autocrine Communication / Q000187:drug effects; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D051900:Smad3 Protein / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D053781:Transforming Growth Factor beta2 / Q000235:genetics* / Q000378:metabolism*
D012333:RNA, Messenger; D011960:Receptors, Estrogen; D051900:Smad3 Protein; D013267:Stilbenes; D053781:Transforming Growth Factor beta2; D000077185:Resveratrol