[Neurodegeneration in experimental stroke--involvement of apoptosis-regulating proteins].
The article presents the state of the art based on experimental studies in vivo and concerning the mechanisms of stroke-induced neurodegeneration in the brain. Molecular bases of differences in brain regions affected indirectly and directly by cortical ischaemia are also discussed. Proteins which may play a key role in apoptosis, including the Bcl-2 protein family, are described in relation to their responses to the infarct. Finally, therapeutic perspectives connected with modulation of function of these proteins are outlined.
Sulejczak
Dorota
D
Zakład Neurofizjologii, Instytut Biologii, Doświadczalnej im. M. Nenckiego PAN. dorotas@cmdik.pan.pl
Skup
Małgorzata
M
D000818:Animals; D017209:Apoptosis; D009410:Nerve Degeneration / Q000503:physiopathology*; D009474:Neurons / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology*
D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2