Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths.
OBJECTIVE
The purpose of this study was to determine factors responsible for the increasing number of deaths from corpus cancer over three time periods.


METHODS
Data were collected from the Surveillance, Epidemiology and End Results database from 1988-2001. Kaplan-Meier and Cox proportional hazards regression analyses were performed.


RESULTS
Of 48,510 women with corpus cancer, there was an increase in the proportion of patients dying from advanced cancers (52.1% to 56.0% to 68.8%; P < .001), grade 3 disease (47.5% to 53.3% to 60.6%; P < .001), serous tumors (14.3% to 18.4% to 16.6%; P < .001), and sarcomas (19.1% to 20.4% to 27.2%; P < .001) over time. On multivariate analysis, older age, African American race, lack of primary staging procedures, advanced-stage, high-grade, and non-endometrioid histology were independent prognostic factors for worse survival.


CONCLUSIONS
Our data suggest that the increase in mortality in women with corpus cancer over the last 14 years may be related to an increased rate of advanced-stage cancers and high-risk histologies.
Ueda
Stefanie M
SM
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, School of Medicine and Comprehensive Cancer Center, San Francisco, CA 94143-1702, USA.
Kapp
Daniel S
DS
Cheung
Michael K
MK
Shin
Jacob Y
JY
Osann
Kathryn
K
Husain
Amreen
A
Teng
Nelson N
NN
Berek
Jonathan S
JS
Chan
John K
JK
D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D002291:Carcinoma, Papillary; D016208:Databases, Factual; D003710:Demography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009367:Neoplasm Staging; D012307:Risk Factors; D018426:SEER Program; D012509:Sarcoma / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality