title: Di(2-ethylhexyl) phthalate exposure during cardiopulmonary bypass.
abstract: Di(2-ethylhexyl) phthalate is an excellent plasticizer for polyvinyl chloride but a known endocrine disrupting chemical. To investigate whether tubing containing no diethylhexyl phthalate reduces the overall extraction of this plasticizer during cardiopulmonary bypass, 16 patients undergoing coronary artery bypass grafting were randomly divided into 2 groups of 8 each. Group A had tubing containing diethylhexyl phthalate in the circuit, and group B had no diethylhexyl phthalate in the tubing. The plasma diethylhexyl phthalate level at the end of cardiopulmonary bypass was significantly increased compared to before anesthesia in both groups (group A: 103 +/- 60 to 2,094 +/- 1,046 ng x mL(-1); group B: 135 +/- 60 to 472 +/- 141 ng x mL(-1)), and it was significantly higher in group A than group B. This study demonstrates that using tubing free from diethylhexyl phthalate significantly reduces the release of this agent during cardiopulmonary bypass, which may minimize exposure to diethylhexyl phthalate.
authors.affiliation: Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Osaka 545-8585, Japan. ysk@msic.med.osaka-cu.ac.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shibata
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujii
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Bito
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Suehiro
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D001026:Coronary Artery Bypass; D004051:Diethylhexyl Phthalate / Q000009:adverse effects / Q000097:blood*; D052244:Endocrine Disruptors / Q000009:adverse effects / Q000097:blood*; D004867:Equipment Design; D006801:Humans; D008297:Male; D008875:Middle Aged; D010968:Plasticizers / Q000009:adverse effects / Q000378:metabolism*; D011446:Prospective Studies; D018570:Risk Assessment; D015854:Up-Regulation
chemical_list: D052244:Endocrine Disruptors; D010968:Plasticizers; D004051:Diethylhexyl Phthalate