title: A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients.
abstract: Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Lin
authors.forename: L
authors.initials: L
authors.lastname: Wan
authors.forename: J J-C
authors.initials: JJ
authors.lastname: Sheu
authors.forename: C-M
authors.initials: CM
authors.lastname: Huang
authors.forename: C-W
authors.initials: CW
authors.lastname: Lin
authors.forename: Y-C
authors.initials: YC
authors.lastname: Lan
authors.forename: C-H
authors.initials: CH
authors.lastname: Lai
authors.forename: C-H
authors.initials: CH
authors.lastname: Hung
authors.forename: Y
authors.initials: Y
authors.lastname: Tsai
authors.forename: C-H
authors.initials: CH
authors.lastname: Tsai
authors.forename: T-H
authors.initials: TH
authors.lastname: Lin
authors.forename: C-P
authors.initials: CP
authors.lastname: Chen
authors.forename: F-J
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index; D013624:Taiwan
chemical_list: D020382:Interleukin-18