Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst.
Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.
Raja
Robert
R
School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK. R.Raja@soton.ac.uk
Thomas
John Meurig
JM
Greenhill-Hooper
Michael
M
Ley
Steven V
SV
Almeida Paz
Filipe A
FA
D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D007539:Isonicotinic Acids / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D009525:Niacin / Q000138:chemical synthesis* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D010847:Picolines / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry
D005663:Furans; D007539:Isonicotinic Acids; D016877:Oxidants; D004364:Pharmaceutical Preparations; D010847:Picolines; D011804:Quinolines; C057608:4-methylquinoline; D009525:Niacin; D009584:Nitrogen; C515325:4-methylpyridine