Fatal attraction: why breast cancer cells home to bone.
Osteolytic metastases due to breast cancer are serious events. The interactions between breast cancer cells with the microenvironment of bone have been thought to provide an ideal milieu for cancer cells. Recent data now indicate that migration of breast cancer cells into bone and their subsequent growth into metastases depends upon the interaction of the receptor activator of NF-kappaB ligand (RANKL) with its receptor RANK.
Hofbauer
Lorenz C
LC
Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University, D-01307 Dresden, Germany. lorenz.hofbauer@uniklinikum-dresden.de
Rachner
Tilman
T
Singh
Shiv K
SK
D001859:Bone Neoplasms / Q000503:physiopathology* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D053245:RANK Ligand / Q000378:metabolism; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000378:metabolism; D015398:Signal Transduction
D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human