[A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer].
Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0.7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from -22.4 x 10(-6) to 36. 1 x 10(-6), among them 90% of the drugs achieved a mass accuracy better than 10 x 10(-6). The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.
Liu
Ke
K
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Ma
Bin
B
Wang
Yong-dong
YD
Chen
Xiao-yan
XY
Zhong
Da-fang
DF
D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012984:Software; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D004364:Pharmaceutical Preparations