Oxidative stress-related gene interactions with preterm delivery in Korean women.
OBJECTIVE
We hypothesized that the cytochrome P450IA1 (CYP1A1), glutathione S-transferases mu 1 (GSTM1), and theta 1 (GSTT1) polymorphisms are associated with the risk for preterm delivery. This study was undertaken to identify gene-gene interactions and haplotypes that increase the risk of preterm delivery.


METHODS
This case-control study was performed in Korea on 145 women with preterm birth and 120 normal controls. Logistic regression and multifactor dimensionality reduction analysis were used to explore single genes and gene-gene interactions, which have an impact on the risk of preterm delivery, respectively.


RESULTS
The GSTM1 null genotype and the interaction between the CYP1A1-I462V and GSTM1 null type conferred a risk of preterm birth. The association between preterm delivery and the CYP1A1-T6235C/I462V haplotype plus GSTM1 null type was verified.


CONCLUSIONS
The interaction between the CYP1A1-I462V and GSTM1 null genotype were found to increase the risk for preterm birth in Korean women. This finding provides evidence of a gene-gene interaction, which has an impact on preterm delivery.
Suh
Young Ju
YJ
Department of Preventive Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea.
Kim
Young Ju
YJ
Park
Hyesook
H
Park
Eun Ae
EA
Ha
Eun Hee
EH
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium / Q000235:genetics; D016015:Logistic Models; D016017:Odds Ratio; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1