title: Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vessels.
abstract: Increasing evidence points to a role for circulating endothelial progenitor cells, including populations of CD34-positive (CD34(+)) cells, in maintenance of cerebral blood flow. In this study, we investigated the link between the level of circulating CD34(+) cells and neovascularization at ischemic brain. Compared with control subjects, a remarkable increase of circulating CD34(+) cells was observed in patients with angiographic moyamoya vessels, although no significant change was observed in patients with major cerebral artery occlusion (or severe stenosis) but without moyamoya vessels. Our results suggest that the increased level of CD34(+) cells associated with ischemic stress is correlated with neovascularization at human ischemic brain.
authors.affiliation: Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yoshihara
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Akie
authors.initials: A
authors.lastname: Kikuchi-Taura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Soma
authors.forename: David M
authors.initials: DM
authors.lastname: Stern
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nagatsuka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Naritomi
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism*; D002465:Cell Movement; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000378:metabolism* / Q000473:pathology
chemical_list: D018952:Antigens, CD34