Effect of compound GB-115 on morphine-induced analgesia.
Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice. This potentiation of antinociceptive activity of morphine was probably related to the interaction of GB-115 with supraspinal opioidergic mechanisms.
Kolik
L G
LG
Department of Pharmacogenetics, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. lgkolik@email.ru
Zhukov
V N
VN
Seredenin
S B
SB
D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*
D000700:Analgesics; D004151:Dipeptides; C520797:GB-115; D009020:Morphine