title: [Pattern-reversal visual evoked potential abnormalities in patients with defined multiple sclerosis].
abstract: BACKGROUND
  Multiple sclerosis is an idiopathic demyelinating disease that may affect the optic nerve leading to acute unilateral visual loss, which could be observed by means of evoked visual potential (VEP). This exam is much valued for studying prechiasmatic visual paths in multiple sclerosis.
  
  
  OBJECTIVE
  To analyze the findings of pattern reversal VEP in patients with prior diagnosis of multiple sclerosis and to compare them to visual acuity.
  
  
  METHODS
  Twenty-four patients with a definite diagnosis of multiple sclerosis were submitted to pattern reversal VEP from October 2001 to March 2007.
  
  
  RESULTS
  In P100 component response, at 15' and 1 degree stimuli, 19 eyes presented latency response up to 115 ms in both stimuli, which coincided in 6 eyes with latency response between 116 and 135 ms; 11 eyes had a latency response higher than 135 ms, and four eyes did not respond to stimuli. Correlating visual acuity with P100 latency for 15', in Pearson r correlation, r=0.85 with p=0.000000123, and for 1 degree, r = 0.87 with p=0.0000000338.
  
  
  CONCLUSIONS
  Approximately 60.4% of patients presented abnormalities. However, the correlation between the P100 latency (15' and 1 degree) and visual acuity was statistically significant; therefore the better the visual acuity, the better the response to stimuli of the pattern-reversal VEP.
authors.affiliation: Universidade de Santo Amaro, São Paulo, SP, Brasil. dr_eric_andrade@hotmail.com
authors.forename: Eric Pinheiro de
authors.initials: EP
authors.lastname: Andrade
authors.forename: Paula Yuri
authors.initials: PY
authors.lastname: Sacai
authors.forename: Adriana
authors.initials: A
authors.lastname: Berezovsky
authors.forename: Solange Rios
authors.initials: SR
authors.lastname: Salomão
mesh_terms: D000293:Adolescent; D000328:Adult; D003627:Data Interpretation, Statistical; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity / Q000502:physiology*; D014795:Visual Pathways / Q000503:physiopathology