The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome.
BACKGROUND
This study was designed to determine if serum cystatin C (Cys C) levels are affected by metabolic syndome and whether they correlate with lipid peroxidation and total antioxidant status (TAS) in this disorder.


METHODS
Cases with metabolic syndrome diagnosed according to the ATP III criteria (18 females, 12 males) were compared with healthy control subjects (20 females, 17 males) matched by age and gender. Plasma Cys C, malondialdehyde (MDA), and TAS levels were studied.


RESULTS
Compared with the controls, Cys C and MDA levels were significantly higher (p<0.001 and p<0.001, respectively), whereas TAS was lower (p<0.001) in metabolic syndrome patients. A significant positive correlation between MDA and Cys C (r=0.308, p<0.05) and a significant negative correlation between TAS and Cys C levels (r=-0.358, p<0.01) were found.


CONCLUSIONS
As Cys C and MDA levels increased but TAS decreased, Cys C may be an important indicator in the pathogenesis of metabolic syndrome.
Demircan
Nejat
N
Department of Family Medicine, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey. nejatdemircantr@yahoo.com
Gurel
Ahmet
A
Armutcu
Ferah
F
Unalacak
Murat
M
Aktunc
Erol
E
Atmaca
Hulusi
H
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged
D000975:Antioxidants; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D008315:Malondialdehyde