title: The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome.
abstract: BACKGROUND
  This study was designed to determine if serum cystatin C (Cys C) levels are affected by metabolic syndome and whether they correlate with lipid peroxidation and total antioxidant status (TAS) in this disorder.
  
  
  METHODS
  Cases with metabolic syndrome diagnosed according to the ATP III criteria (18 females, 12 males) were compared with healthy control subjects (20 females, 17 males) matched by age and gender. Plasma Cys C, malondialdehyde (MDA), and TAS levels were studied.
  
  
  RESULTS
  Compared with the controls, Cys C and MDA levels were significantly higher (p<0.001 and p<0.001, respectively), whereas TAS was lower (p<0.001) in metabolic syndrome patients. A significant positive correlation between MDA and Cys C (r=0.308, p<0.05) and a significant negative correlation between TAS and Cys C levels (r=-0.358, p<0.01) were found.
  
  
  CONCLUSIONS
  As Cys C and MDA levels increased but TAS decreased, Cys C may be an important indicator in the pathogenesis of metabolic syndrome.
authors.affiliation: Department of Family Medicine, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey. nejatdemircantr@yahoo.com
authors.forename: Nejat
authors.initials: N
authors.lastname: Demircan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurel
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
authors.forename: Murat
authors.initials: M
authors.lastname: Unalacak
authors.forename: Erol
authors.initials: E
authors.lastname: Aktunc
authors.forename: Hulusi
authors.initials: H
authors.lastname: Atmaca
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D008315:Malondialdehyde