Insect growth regulatory effects of linear diterpenoids and derivatives from Baccharis thymifolia.
Linear diterpenes isolated from aerial parts of Baccharis thymifolia ( 1- 3) were tested for insect growth inhibitory activity against Tenebrio molitor larvae. Compounds 4- 16 were prepared by various chemical transformations. The diterpenes 6,10-( E,E)-thymifodioic acid ( 1), the butenolide 3, and the derivatives 4, 11, and 14 produced developmental deficiencies in assays using topical application on fifth instar larvae of T. molitor. Compound 3 is a new natural product.
Juan Hikawczuk
Virginia E
VE
Facultad de Química, Bioquíca y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina.
Saad
J Roberto
JR
Giordano
Oscar S
OS
García
Celina
C
Martín
Tomás
T
Martín
Víctor S
VS
Sosa
Marta E
ME
Tonn
Carlos E
CE
D000818:Animals; D001118:Argentina; D031175:Baccharis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013712:Tenebrio / Q000187:drug effects
C528157:(2E,6E)-2-(4-methylpent-3-enyl)-6-(3-(2-oxo-2,5-dihydrofuran-3-yl)propyli-dene)hept-2-enedioic acid; D004224:Diterpenes; D007306:Insecticides