title: Length-based encoding of binary data in DNA.
abstract: We developed a system to encode digital information in DNA polymers based on the partial restriction digest (PRD). Our encoding method relies on the length of the fragments obtained by the PRD rather than the actual content of the nucleotide sequence, thus eliminating the need for expensive sequencing machinery. In this letter, we report on the encoding of 12 bits of data in a DNA fragment of 110 nucleotides and the process of recovering the data.
authors.affiliation: Department of Bioengineering, University of California, Riverside, California 92521, USA.
authors.forename: Nathaniel G
authors.initials: NG
authors.lastname: Portney
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wu
authors.forename: Lauren K
authors.initials: LK
authors.lastname: Quezada
authors.forename: Stefano
authors.initials: S
authors.lastname: Lonardi
authors.forename: Mihrimah
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D005822:Genetic Vectors / Q000737:chemistry; D010316:Particle Size; D010957:Plasmids; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D004247:DNA