title: Delivery of renal replacement therapy in acute kidney injury: what are the key issues?
abstract: OBJECTIVE
  The prescription and delivery of renal replacement therapy for acute kidney injury is subject to a wide variation and is conditioned by a multiplicity of factors. A variety of renal replacement therapy modalities are now available to treat acute kidney injury; however, there are no standards for the dosage, choice of modality, and intensity and duration of these therapies. Although several observational and interventional studies have addressed these topics, there are no consensus recommendations in this field.
  
  
  METHODS
  The available literature on this topic and draft consensus recommendations for research studies in this area were developed using a modified Delphi approach and an international multidisciplinary network.
  
  
  RESULTS
  The following questions were most important: What is the "dosage" of renal replacement therapy delivered to patients with stage 3 acute kidney injury? What is the optimal "dosage" of renal replacement therapy to maximize patient and renal survival? Is there a minimal "dosage" of renal replacement therapy required in patients with single-organ failure? Does modality of renal replacement therapy selected have an effect on patient and/or renal survival? In cases of continuous renal replacement therapy, does citrate anticoagulation confer a benefit?
  
  
  CONCLUSIONS
  This report summarizes the available evidence and elaborates on the key questions and the methods that should be used so that the goal of standardizing the care of patients with acute kidney injury and improving outcomes can be achieved.
authors.affiliation: UCL Center for Nephrology, Royal Free & University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK. andrew.davenport@royalfree.nhs.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
authors.forename: Catherine
authors.initials: C
authors.lastname: Bouman
authors.forename: Ashok
authors.initials: A
authors.lastname: Kirpalani
authors.forename: Peter
authors.initials: P
authors.lastname: Skippen
authors.forename: Ashita
authors.initials: A
authors.lastname: Tolwani
authors.forename: Ravindra L
authors.initials: RL
authors.lastname: Mehta
authors.forename: Paul M
authors.initials: PM
authors.lastname: Palevsky
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality / Q000628:therapy*; D035843:Biomedical Research / Q000458:organization & administration*; D003661:Decision Support Techniques; D003695:Delivery of Health Care / Q000592:standards; D003697:Delphi Technique; D019317:Evidence-Based Medicine; D017144:Focus Groups; D006801:Humans; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D016730:Program Development; D017582:Renal Replacement Therapy / Q000592:standards; D016896:Treatment Outcome