title: Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin.
abstract: The synthesis of three series of curcumin analogues with mono-carbonyl is described. Their in vitro anti-bacterial activities against seven Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the aryl ring and the space structure of the linking strain were discussed. It was observed that part of the derivatives displayed significant activity when compared with curcumin and most of them exhibited activity against the ampicillin-resisted Enterobacter cloacae. Compounds A12, B09, B13, B14 and C09 show remarkable antibacterial activity in vitro. The result showed that heterocycle or long-chain substituents may enhance the activity of curcumin analogues.
authors.affiliation: College of Chemistry, Nanjing University of Science and Technology, Nanjing, PR China.
authors.forename: Guang
authors.initials: G
authors.lastname: Liang
authors.forename: Shulin
authors.initials: S
authors.lastname: Yang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lili
authors.initials: L
authors.lastname: Shao
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Faqing
authors.initials: F
authors.lastname: Ye
authors.forename: Yueru
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D003474:Curcumin