Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
Zhou
Chunhui
C
Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
Min
Jaeki
J
Liu
Zhigang
Z
Young
Anne
A
Deshazer
Heather
H
Gao
Tian
T
Chang
Young-Tae
YT
Kallenbach
Neville R
NR
D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014227:Triazines