[Clinical study on the improvement of ischemia condition with stem cell transplantation in 122 cases necrosis of femoral head].
OBJECTIVE
To observe the curative effects of bone marrow stem cell (BMSC) and peripheral blood stem cell (PBSC) transplantations on the avascular necrosis of femoral head (ANFH).


METHODS
Totally 122 ANFH patients (211 coxae) treated by BMSC or PBSC transplantations were enrolled from July 2004 to December 2006. All of them were classed to different stages according to the ARCO. Control group were desired as themselves before and after treatment. The puncture of femoral artery was conducted with digital subtraction angiography (DSA), and the tubes were inserted into medial femoral circumflex artery, lateral femoral circumflex artery and obturator artery with the cell suspensions were gradually poured into the arteries.


RESULTS
The joint pain, joint functions and walking distance of 122 patients were detected for the follow-up. Compared with before treatment, the calibers thickened; vessels increased and blood velocity quickened of femoral head blood-supply artery were observed in 15 patients after 6 months checked by DSA. The reduced areas of femoral head necrosis in 8 patients indicated the new bone formation between 12 and 24 months.


CONCLUSIONS
Autologous BMSC and PBSC transplantation results in the new bone formation and improvement of ischemia in areas of femoral head necrosis at 6 months. The change of angiography was observed about 12 to 24 months after cell transplantation. The stem cell transplantation is convenient, safe and effective in the treatment of the ANFH with no adverse reaction, and can be considered as a new therapy of ANFH.
Yang
Xiao-Feng
XF
Cell Treatment Center, People's Liberation Army 463 Hospital, Shenyang, China. yxf463@yahoo.com
Wang
Hong-Mei
HM
Xu
Yi-Feng
YF
Zang
Yi-Bin
YB
Wu
Yan-Xiang
YX
Lü
Xin
X
Lü
Nai-Wu
NW
Shan
Hong
H
D016026:Bone Marrow Transplantation; D005270:Femur Head / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D005271:Femur Head Necrosis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000601:surgery; D036102:Peripheral Blood Stem Cell Transplantation; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome