title: Primary mucosa-associated lymphoid tissue lymphoma of the prostate: tumor relapse 7 years after local therapy.
abstract: Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the prostate is rare, and only five cases have been reported. Reported herein is a new case that has involved a 9 year follow up. A 79-year-old man was treated with transurethral resection (TUR) for a mass of the right prostatic lobe, and followed up under a diagnosis of benign prostatic hyperplasia with atypical lymphoid infiltration. Seven years later TUR was again performed for a right lobe mass. The lesion was diagnosed as a relapsed MALT lymphoma after detailed histological and immunoglobulin heavy chain gene analyses of the initial and relapsed lesions. Interestingly, lymphoepithelial lesions were observed only infrequently in this tumor. The API2-MALT1 fusion, a gene alteration specific to MALT lymphoma, was absent. The patient had stage IA disease at the time of tumor relapse, and has been alive and well for the 2 years after the second TUR. The present case suggests that despite tumor recurrence, prostatic MALT lymphoma is indolent, and function-preserving therapy is warranted.
authors.affiliation: Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Hibino
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Komatsu
authors.forename: Hidenori
authors.initials: H
authors.lastname: Sakuma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakakura
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Eimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011467:Prostate / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D011859:Radiography; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains