title: Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach.
abstract: Experiments on smooth muscles of rat stomach showed that lysophosphatidylcholine in concentrations of 10(-8) and 10(-7) g/ml does not modulate the tonotropic effect of acetylcholine (10(-6) g/ml), in a concentration of 10(-6) g/ml potentiated this effect (similarly to phosphatidylcholine, 10(-6) g/ml), and reduced it in concentrations of 10(-5)-10(-4) g/ml (similarly to hen egg yolk in dilutions of 1:500, 1:100, and 1:500). These data indicate that lysophosphatidylcholine modifies signal transduction from the receptor to G protein.
authors.affiliation: Department of Normal Physiology, Kirov State Medical Academy, Moscow.
authors.forename: A A
authors.initials: AA
authors.lastname: Kunshin
authors.forename: V I
authors.initials: VI
authors.lastname: Tsyrkin
authors.forename: N V
authors.initials: NV
authors.lastname: Prokazova
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004530:Egg Yolk; D005260:Female; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology; D013270:Stomach / Q000187:drug effects / Q000502:physiology
chemical_list: D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D011976:Receptors, Muscarinic; D000109:Acetylcholine