title: [D-lactic acidosis in a child with short bowel syndrome].
abstract: BACKGROUND
  d-lactic acidosis is a rare and severe complication of short bowel syndrome in children that may result from important ileal bacterial overgrowth by lactobacilli. Intestinal flora (Lactobacilli) is responsible for the production of d-lactic acid after fermentation of food carbohydrates.
  
  
  METHODS
  We report on the case of a 6-year-old child with a short bowel syndrome treated with both home enteral and parenteral nutrition. The patient suddenly presented with acute neurological symptoms including dysarthria and disorientation. Biological analysis revealed metabolic acidosis, increased plasma d-lactic acid assessed by organic acid chromatography analysis and a very important increase in expired hydrogen during glucose breath test. Lactobacillus fermentum (known to produce d and L isomers of lactic acid) was isolated in the gastric liquid and rectal swabs. Clinical and biological evolution was rapidly favourable after treatment with intravenous sodium bicarbonate, antibiotic therapy and interruption of enteral nutrition.
  
  
  CONCLUSIONS
  d-lactic acidosis should be suspected when neurological symptoms occur in a child with short bowel syndrome. They can be prevented by treating intestinal bacterial overgrowth.
authors.affiliation: Unité de gastroentérologie, hépatologie et nutrition, hôpital Jeanne-de-Flandres, avenue Eugène-Avinée, Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Dahhak
authors.forename: S
authors.initials: S
authors.lastname: Uhlen
authors.forename: K
authors.initials: K
authors.lastname: Mention
authors.forename: M-B
authors.initials: MB
authors.lastname: Romond
authors.forename: M
authors.initials: M
authors.lastname: Fontaine
authors.forename: F
authors.initials: F
authors.lastname: Gottrand
authors.forename: D
authors.initials: D
authors.lastname: Turck
authors.forename: L
authors.initials: L
authors.lastname: Michaud
mesh_terms: D000140:Acidosis, Lactic / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007422:Intestines / Q000382:microbiology; D019344:Lactic Acid / Q000096:biosynthesis; D007778:Lactobacillus / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D008297:Male; D010288:Parenteral Nutrition; D012778:Short Bowel Syndrome / Q000150:complications*; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019344:Lactic Acid; D017693:Sodium Bicarbonate