Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
Jain
Rakesh K
RK
Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America. Jain@steele.mgh.harvard.edu
Lahdenranta
Johanna
J
Fukumura
Dai
D
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001549:Benzamides; D002277:Carcinoma / Q000098:blood supply / Q000188:drug therapy*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D000068877:Imatinib Mesylate; D051379:Mice; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000201:enzymology; D019899:Paracrine Communication / Q000187:drug effects; D020286:Pericytes / Q000187:drug effects / Q000201:enzymology; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000188:drug therapy*
D000970:Antineoplastic Agents; D001549:Benzamides; D009363:Neoplasm Proteins; D010879:Piperazines; D010982:Platelet-Derived Growth Factor; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D017479:Receptors, Platelet-Derived Growth Factor