Pathomorphological and immunohistochemical analysis of autoimmune processes in the thyroid gland.
The morphology and function of TG were studied in residents of an East Kazakhstan region with unfavorable ecology. One-third of the population developed autoimmune processes in this organ. The morphogenesis and regenerative processes in the thyroid gland against the background cellular infiltration were studied. Irrespective of the morphogenesis stage, the autoimmune processes in the thyroid gland were paralleled by dysregulatory disorders in the follicular epithelium which in many cases acquired immunohistochemical characteristics of the main cells of the parathyroid glands. Structural reorganization was paralleled by changes in the cell composition of the stroma, focal hyperplasia of oncocytes and C-cells, and enhanced angiogenesis.
Androsova
D S
DS
Department of Pathological Anatomy, Semipalatinsk State Medical Academy, Kazakhstan.
Barakat
M Yu
MY
Pruglo
Yu V
YV
D017209:Apoptosis; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D001402:B-Lymphocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010281:Parathyroid Hormone / Q000378:metabolism; D013601:T-Lymphocytes / Q000473:pathology; D013959:Thyroid Diseases / Q000276:immunology* / Q000473:pathology*; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology*
D010281:Parathyroid Hormone