title: Intron F G79A polymorphism of the protein Z gene in cancer patients with and without thrombosis.
abstract: OBJECTIVE
  Venous thromboembolism (VTE) is well-recognized complication of cancer; however its pathogenesis is not entirely established. Protein Z (PZ) is a member of the coagulation cascade. We aimed to investigate whether intron F G79A polymorphism of PZ gene is associated with risk of VTE in cancer patients.
  
  
  METHODS
  The study consisted of 55 cancer patients who developed thrombosis (group 1) and 115 cancer patients without VTE (group 2). Intron F G79A of PZ gene, factor V Leiden (FVL) and prothrombin (PT) G20210A polymorphisms were determined by the method of polymerase chain reaction-based DNA analysis.
  
  
  RESULTS
  The prevalence of FVL was significantly greater in group 1 compared with group 2 (27.3% vs. 3.5%, P < 0.0001). No differences were seen in genotype and allele frequencies of PZ gene between two groups (P > 0.05). When the analysis was also made after excluding FVL positive patients, the same insignificant result was found.
  
  
  CONCLUSIONS
  Intron F G79A polymorphism of PZ gene does not contribute to meaningful diagnostic investigation of thrombophilia in cancer patients.
authors.affiliation: Department of Surgery, Numune State Hospital, Konya 42050, Turkey. aydaneroglu@hotmail.com
authors.forename: Aydan
authors.initials: A
authors.lastname: Eroglu
authors.forename: Aysenur
authors.initials: A
authors.lastname: Ozturk
authors.forename: Ragip
authors.initials: R
authors.lastname: Cam
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000235:genetics* / Q000502:physiology; D004252:DNA Mutational Analysis; D005165:Factor V / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D001798:Blood Proteins; C095381:factor V Leiden; C026080:plasma protein Z; D005165:Factor V; D011516:Prothrombin