Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in helix lucorum.
Injection of antibodies to Ca-binding protein S-100 in a dilution of 10(-12) before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization as a neurobiological model of anxiety and depression.
Epstein
O I
OI
Materia Medica Company, Moscow, Russia.
Stark
M B
MB
Timoshenko
A Kh
AKh
Gainutdinova
T Kh
TKh
Gainutdinov
Kh L
KhL
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001007:Anxiety / Q000276:immunology; D003863:Depression / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006372:Helix, Snails; D008954:Models, Biological; D009418:S100 Proteins / Q000276:immunology*
D000906:Antibodies; D009418:S100 Proteins