title: [Genomic approaches to bone and joint diseases. An order made medical system for management of osteoporosis: an attempt using genetic information].
abstract: An effort was made to establish an order made medical system for management of osteoporosis. A T --> C polymorphism in exon 1 of the transforming growth factor-beta 1 gene, which is associated with the rate of bone loss as well as the response to active vitamin D treatment, was used to select high responder to active vitamin D treatment. We also determined serum level of 25 hydroxy-vitamin D to evaluate a degree of vitamin D deficiency. Based on these data, we categorized patients into four groups ; high responder with vitamin D deficiency to whom 1 microg/day active vitamin D was administered, high responder without vitamin D deficiency or low responder with vitamin D deficiency to whom 0.5 microg/day active vitamin D was administered, and low responder without vitamin D deficiency to whom no drug was given. The patients have been checked up every 6 months with regard to changes in bone mineral density and occurrence of fresh fractures. So far, it was found that the SNP is associated with prevalent vertebral fractures ; the frequency of the T allele was significantly greater in patients with vertebral fractures, indicating that the SNP can predict the fracture risk.
authors.affiliation: Tokyo Metropolitan Geriatric Hospital.
authors.forename: Seijiro
authors.initials: S
authors.lastname: Mori
mesh_terms: D000368:Aged; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000235:genetics*; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D014807:Vitamin D