[Cell surface antigen expression of orbital preadipocytes between patients with thyroid-associated ophthalmopathy and healthy adults].
OBJECTIVE
To study the cell surface antigen expression of orbital preadipocytes between patients with thyroid-associated ophthalmopathy (TAO) and healthy adults.


METHODS
Tissue culture Methods were used in the cell culture of orbital preadipocytes in patients with TAO and healthy adults. Flow cytometry was used to analyze the expression of CD29, CD44, CD49d, and HLA-DR in these 2 cells.


RESULTS
Positive expressions were examined in orbital preadipocytes of patients with TAO and healthy adults. The orbital preadipocytes of patients with TAO had a higher expression of HLA-DR than that of healthy adults.


CONCLUSIONS
The orbital preadipocytes of patients with TAO and healthy adults cultured by tissue cultured Methods both belong to mesenchymal stem cells, and the former may participate in the orbital inflammation.
Lei
Xiang
X
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xu
Xue-liang
XL
D017667:Adipocytes / Q000276:immunology*; D000328:Adult; D000954:Antigens, Surface / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D049970:Graves Ophthalmopathy / Q000276:immunology* / Q000378:metabolism; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology; D019012:Integrin beta1 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000276:immunology* / Q000378:metabolism
D000954:Antigens, Surface; D006684:HLA-DR Antigens; D018960:Hyaluronan Receptors; D019012:Integrin beta1