Oxidative stress and chronic kidney disease.
Slowing the rate of progression of chronic kidney disease (CKD) is a critical part of the management of affected dogs and cats. Renal oxidant stress is a previously unrecognized factor in the progression of canine CKD and is likely to be similarly important in feline CKD. Renin-angiotensin antagonism, calcium channel antagonism, n-3 polyunsaturated fatty acid, and antihypertensive and antiproteinuric therapy are commonly recommended for dogs and cats with CKD. These therapies would be expected to reduce renal oxidant stress by decreasing reactive oxygen species generation. Newer data indicate that dietary supplementation with specific antioxidants is an important consideration for limiting renal oxidant stress and progression of CKD.
Brown
Scott A
SA
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, 501 D.W. Brooks Drive, University of Georgia, Athens, GA 30602, USA. sbrown@vet.uga.edu
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D015220:Calcium Channels; D002371:Cat Diseases / Q000188:drug therapy* / Q000517:prevention & control; D002415:Cats; D018450:Disease Progression; D004283:Dog Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004285:Dogs; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D018384:Oxidative Stress / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000975:Antioxidants; D015220:Calcium Channels; D015525:Fatty Acids, Omega-3