title: Mitochondria--a nexus for aging, calorie restriction, and sirtuins?
abstract: Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA. leng@mit.edu
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D037761:Sirtuins
chemical_list: D037761:Sirtuins