The contribution of growth hormone to mammary neoplasia.
While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.
Perry
Jo K
JK
The Liggins Institute, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland, New Zealand.
Mohankumar
Kumarasamypet M
KM
Emerald
B Starling
BS
Mertani
Hichem C
HC
Lobie
Peter E
PE
D000818:Animals; D019898:Autocrine Communication; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004195:Disease Models, Animal; D013006:Growth Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D012307:Risk Factors
D013006:Growth Hormone