title: [Neurodegeneration in experimental stroke--involvement of apoptosis-regulating proteins].
abstract: The article presents the state of the art based on experimental studies in vivo and concerning the mechanisms of stroke-induced neurodegeneration in the brain. Molecular bases of differences in brain regions affected indirectly and directly by cortical ischaemia are also discussed. Proteins which may play a key role in apoptosis, including the Bcl-2 protein family, are described in relation to their responses to the infarct. Finally, therapeutic perspectives connected with modulation of function of these proteins are outlined.
authors.affiliation: Zakład Neurofizjologii, Instytut Biologii, Doświadczalnej im. M. Nenckiego PAN. dorotas@cmdik.pan.pl
authors.forename: Dorota
authors.initials: D
authors.lastname: Sulejczak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Skup
mesh_terms: D000818:Animals; D017209:Apoptosis; D009410:Nerve Degeneration / Q000503:physiopathology*; D009474:Neurons / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2