Tissue availability of afobazole and its major metabolites in rats.
Intraperitoneally injected afobazole and its major metabolites are intensively distributed in highly vascularized tissues of rats, including the liver, spleen, and kidneys; the content of these compounds in moderately and poorly vascularized tissues (muscles and mesentery) is much lower. Afobazole and its metabolites possess intermediate ability to penetrate into the brain.
Viglinskaya
A O
AO
Laboratory of Pharmacokinetics, V V Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Kolyvanov
G B
GB
Litvin
A A
AA
Kravtsova
O Yu
OY
Zherdev
V P
VP
Seredenin
S B
SB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001562:Benzimidazoles / Q000493:pharmacokinetics*; D001682:Biological Availability; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D009025:Morpholines / Q000493:pharmacokinetics*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines