Structural and functional changes in myocardial thin filaments in experimental hypothyrosis.
Fluorescence resonance energy transfer study revealed decreased intermonomer mobility of Ca-actin and Mg-actin filaments of myocardial myofibrils in myocardial dystrophy caused by diffuse endocrine disorders, e. g. hypothyrosis. Cis374 axial distance in Ca-actin filament protomer increased in hypothyrosis. Intracellular pH has no effect on inter-monomer mobility of Ca-actin filament.
Sukoyan
G V
GV
N V Karsanov National Center of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi, Russia.
Berberashvili
T M
TM
Asatiani
K Dzh
KD
D000199:Actins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D005260:Female; D007037:Hypothyroidism / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009282:Naphthalenesulfonates; D051381:Rats
D000199:Actins; D009282:Naphthalenesulfonates; C006421:1,5-I-AEDANS