title: Identification of a novel vardenafil analogue in herbal product.
abstract: A new herbal health product marketed for enhancing erectile function, namely Power58 Platinum, was purchased over-the-counter in Hong Kong. The product was tested for adulteration with sildenafil, tadalafil, and vardenafil as well as their structurally modified analogues. A new analogue of vardenafil, in which the N-ethylpiperazine ring and the sulphonyl group were removed from the vardenafil structure, was identified in the product.
authors.affiliation: Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Lai King Hill Road, Lai Chi Kok, Hong Kong Special Administrative Region, Hong Kong, China.
authors.forename: Ying-Hoo
authors.initials: YH
authors.lastname: Lam
authors.forename: Wing-Tat
authors.initials: WT
authors.lastname: Poon
authors.forename: Chi-Kong
authors.initials: CK
authors.lastname: Lai
authors.forename: Albert Yan-Wo
authors.initials: AY
authors.lastname: Chan
authors.forename: Tony Wing-Lai
authors.initials: TW
authors.lastname: Mak
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D007093:Imidazoles / Q000032:analysis*; D010726:Phosphodiesterase Inhibitors / Q000032:analysis*; D010879:Piperazines / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013450:Sulfones / Q000032:analysis; D014227:Triazines / Q000032:analysis; D000069058:Vardenafil Dihydrochloride
chemical_list: D004365:Drugs, Chinese Herbal; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride