title: One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives.
abstract: A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98- >99 ee).
authors.affiliation: Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm (Sweden).
authors.forename: Jan
authors.initials: J
authors.lastname: Vesely
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios
authors.forename: Ismail
authors.initials: I
authors.lastname: Ibrahem
authors.forename: Gui-Ling
authors.initials: GL
authors.lastname: Zhao
authors.forename: Lars
authors.initials: L
authors.lastname: Eriksson
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003508:Cycloheptanes / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008958:Models, Molecular; D015394:Molecular Structure; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D003508:Cycloheptanes