Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism.
Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.
Artem'eva
O V
OV
Department of Ambulatory Therapy and Functional Diagnostics, N. P. Ogarev Mordovian State University, Saransk.
Koryaikina
A V
AV
Zor'kina
A V
AV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D008012:Lidocaine