title: Nitric oxide selective electrodes.
abstract: Since nitric oxide (NO) was identified as the endothelial-derived relaxing factor in the late 1980s, many approaches have attempted to provide an adequate means for measuring physiological levels of NO. Although several techniques have been successful in achieving this aim, the electrochemical method has proved the only technique that can reliably measure physiological levels of NO in vitro, in vivo, and in real time. We describe here the development of electrochemical sensors for NO, including the fabrication of sensors, the detection principle, calibration, detection limits, selectivity, and response time. Furthermore, we look at the many experimental applications where NO selective electrodes have been successfully used.
authors.affiliation: World Precision Instruments Limited, Aston, United Kingdom.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Davies
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002244:Carbon; D000077482:Carbon Fiber; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods / Q000706:statistics & numerical data; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008839:Microelectrodes; D009569:Nitric Oxide / Q000032:analysis* / Q000502:physiology; D026423:S-Nitroso-N-Acetylpenicillamine; D012680:Sensitivity and Specificity; D013696:Temperature
chemical_list: D000077482:Carbon Fiber; D009569:Nitric Oxide; D002244:Carbon; D026423:S-Nitroso-N-Acetylpenicillamine