Effect of systemic treatment with antibodies against glutamate on the seizure response of C57Bl/6 mice after pentylenetetrazole kindling.
We studied the effect of single intraperitoneal injection of antibodies against glutamate on acute generalized epileptiform activity induced by intravenous injection of pentylenetetrazole in kindled C57Bl/6 mice. We found that in animals at various stages of kindling, administration of antibodies against glutamate in a dose of 25 mg/kg 1.5 h before testing increases the threshold of clonic seizures and tonic phase of seizures with lethal outcome and latency of seizure development, i.e. produces an antiepileptic effect.
Karpova
M N
MN
Laboratory of Epileptogenesis and Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. niiopp@mail.ru
Vetrile
L A
LA
Kuznetsova
L V
LV
Klishina
N Yu
NY
Trekova
N A
NA
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology; D018698:Glutamic Acid / Q000276:immunology*; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control
D000906:Antibodies; D000927:Anticonvulsants; D018698:Glutamic Acid; D010433:Pentylenetetrazole