title: Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH.
abstract: Three new sesquiterpene lactones, (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide (1), (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide (2) and 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1-5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.
authors.affiliation: Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun. ttabopda@yahoo.fr
authors.forename: Turibio Kuiate
authors.initials: TK
authors.lastname: Tabopda
authors.forename: Joseph
authors.initials: J
authors.lastname: Ngoupayo
authors.forename: Jiawei
authors.initials: J
authors.lastname: Liu
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shaiq Ali
authors.forename: Shamsun Nahar
authors.initials: SN
authors.lastname: Khan
authors.forename: Bonaventure Tchaleu
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Bang
authors.initials: B
authors.lastname: Luu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004396:Coloring Agents; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012235:Rhodamines; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: C527318:(4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide; C527319:(4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide; C527320:2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide; D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D007783:Lactones; D012235:Rhodamines; D012717:Sesquiterpenes; C022027:lissamine rhodamine B