Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives.
Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10(-3) M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.
Kerimov
Ilgar
I
Department of Pharmaceutical Chemistry Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.
Ayhan-Kilcigil
Gülgün
G
Can-Eke
Benay
B
Altanlar
Nurten
N
Iscan
Mümtaz
M
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D000975:Antioxidants; D001562:Benzimidazoles; D002110:Caffeine; C031000:benzimidazole