title: Cardio-ankle vascular index measures arterial wall stiffness independent of blood pressure.
abstract: Although brachial-ankle pulse wave velocity (baPWV) is a non-invasive method of detecting arteriosclerosis, it is affected by changes in blood pressure (BP). Cardio-ankle vascular index (CAVI) is a new method for estimating arteriosclerosis, and it has been reported to be less influenced by BP. We investigated the influence of BP changes on CAVI and the correlation of CAVI to clinical factors and carotid arteriosclerosis. CAVI and baPWV in 35 non-diabetic and 33 diabetic subjects were measured in increased BP (after stair climbing) and rested BP (after 10min of rest). Intima-media thickness (IMT) of carotid arteries was measured by ultrasoundsonography. We achieved the following results: CAVI did not show a significant change with a change in BP in both non-diabetic and diabetic subjects. On the contrary, baPWV was significantly influenced by BP changes. Carotid artery IMT had a significant positive correlation with CAVI and baPWV. Multiple regression analysis revealed that significant risk factors of high baPWV were age and systolic BP. On the contrary, significant risk factors of high CAVI were age and hemoglobin A1c, while systolic BP was not relevant. Our findings suggest that CAVI is independent of BP and useful as an indicator of early arteriosclerosis in diabetic subjects.
authors.affiliation: The First Department of Medicine, Wakayama Medical University, Kimiidera 811-1, Wakayama, P.O. 641-8509, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ibata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kakimoto
authors.forename: Shohei
authors.initials: S
authors.lastname: Matsuno
authors.forename: Muneki
authors.initials: M
authors.lastname: Nakatani
authors.forename: Masato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakano
authors.forename: Hisao
authors.initials: H
authors.lastname: Wakasaki
authors.forename: Hiroto
authors.initials: H
authors.lastname: Furuta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishi
authors.forename: Kishio
authors.initials: K
authors.lastname: Nanjo
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000098:blood supply; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology* / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D003925:Diabetic Angiopathies / Q000503:physiopathology* / Q000534:rehabilitation; D003971:Diastole; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010353:Patient Education as Topic; D012016:Reference Values; D013599:Systole; D014280:Triglycerides / Q000097:blood
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin; D014280:Triglycerides