title: Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.
abstract: Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P=0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children.
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Josefin A
authors.initials: JA
authors.lastname: Jacobsson
authors.forename: Pernilla
authors.initials: P
authors.lastname: Danielsson
authors.forename: Victoria
authors.initials: V
authors.lastname: Svensson
authors.forename: Janis
authors.initials: J
authors.lastname: Klovins
authors.forename: Ulf
authors.initials: U
authors.lastname: Gyllensten
authors.forename: Claude
authors.initials: C
authors.lastname: Marcus
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
authors.forename: Robert
authors.initials: R
authors.lastname: Fredriksson
mesh_terms: D000293:Adolescent; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D002648:Child; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011506:Proteins / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human