Site isolated base and acid catalyzed azaspirocyclization cascades.
A one-pot, site isolated base (PS-BEMP) and acid (Si-TsOH) catalyzed cyclization cascade to azaspirocyclic molecules is reported; the reaction is simple to perform, atom efficient (water is the only byproduct) and broad in its scope to a diverse range of azaspirocyclic products.
Pilling
Adam W
AW
School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK.
Böhmer
Jutta
J
Dixon
Darren J
DJ