title: Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.
abstract: In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of phosphatidylinositol 3-kinase (PI3K), the entire primordial follicle pool becomes activated. Subsequently, all primordial follicles become depleted in early adulthood, causing premature ovarian failure (POF). Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Reddy
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.forename: Deepak
authors.initials: D
authors.lastname: Adhikari
authors.forename: Krishna
authors.initials: K
authors.lastname: Jagarlamudi
authors.forename: Singareddy
authors.initials: S
authors.lastname: Rajareddy
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Chun
authors.initials: C
authors.lastname: Du
authors.forename: Wenli
authors.initials: W
authors.lastname: Tang
authors.forename: Tuula
authors.initials: T
authors.lastname: Hämäläinen
authors.forename: Stanford L
authors.initials: SL
authors.lastname: Peng
authors.forename: Zi-Jian
authors.initials: ZJ
authors.lastname: Lan
authors.forename: Austin J
authors.initials: AJ
authors.lastname: Cooney
authors.forename: Ilpo
authors.initials: I
authors.lastname: Huhtaniemi
authors.forename: Kui
authors.initials: K
authors.lastname: Liu
mesh_terms: D000818:Animals; D005260:Female; D005496:Follicular Atresia; D051379:Mice; D008822:Mice, Transgenic; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D009929:Organ Size; D006080:Ovarian Follicle / Q000166:cytology / Q000502:physiology*; D010053:Ovary / Q000033:anatomy & histology / Q000502:physiology; D010060:Ovulation; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D016649:Primary Ovarian Insufficiency / Q000503:physiopathology; D011494:Protein Kinases / Q000378:metabolism; D038601:Ribosomal Protein S6 / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases
chemical_list: D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D038601:Ribosomal Protein S6; D058570:TOR Serine-Threonine Kinases; C546843:mTOR protein, mouse; C487757:Pten protein, mouse