Study of antileprosy activities of some dialkyldithiocarbamate derivatives.
Effects of some dialkyldithiocarbamate derivatives on multiplication of M. leprae were studied in infected mice. Compounds significantly suppressing M. leprae proliferation were selected. By antibacterial activity one of these compounds was superior to dapsone, the main antileprosy drug.
Urlyapova
N G
NG
Institute of Leprosy Research, Russian Ministry of Health, Astrakhan. niil@astmail.astranet
Yushchenko
A A
AA
Daudova
A D
AD
Makarov
V A
VA
D000818:Animals; D015169:Colony Count, Microbial; D003622:Dapsone / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007917:Leprostatic Agents / Q000494:pharmacology*; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D008808:Mice, Inbred CBA; D009166:Mycobacterium leprae / Q000187:drug effects; D013859:Thiocarbamates / Q000494:pharmacology*
D007917:Leprostatic Agents; D013859:Thiocarbamates; D003622:Dapsone