title: Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.
abstract: Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.
authors.affiliation: Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: M
authors.initials: M
authors.lastname: Früh
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Zhai
authors.forename: L
authors.initials: L
authors.lastname: Su
authors.forename: R S
authors.initials: RS
authors.lastname: Heist
authors.forename: J C
authors.initials: JC
authors.lastname: Wain
authors.forename: N S
authors.initials: NS
authors.lastname: Nishioka
authors.forename: T J
authors.initials: TJ
authors.lastname: Lynch
authors.forename: F A
authors.initials: FA
authors.lastname: Shepherd
authors.forename: D C
authors.initials: DC
authors.lastname: Christiani
authors.forename: G
authors.initials: G
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D016480:Helicobacter pylori / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D053508:Matrix Metalloproteinase 12 / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D019278:Matrix Metalloproteinase 3; D020778:Matrix Metalloproteinase 2; D053508:Matrix Metalloproteinase 12; D020781:Matrix Metalloproteinase 1