Allogeneic hematopoietic stem cell transplantation using a reduced-intensity conditioning regimen in infants: experience at a single institution in Mexico.
The authors report their experience with allogeneic hematopoietic stem cell transplantation in infants at a university hospital in México. Five infants had one of each of the following diagnoses: acute lymphoblastic leukemia, osteopetrosis for which the patient underwent 2 procedures, acute disseminated multiorgan Langerhans cell histiocytosis, and two cases of hemophagocytic lymphohistiocytosis. The source of stem cells for grafting in 2 children was peripheral blood, and in 3 children was unrelated cord blood. A reduced-intensity conditioning regimen including fludarabine, cyclophosphamide, and melphalan was administrated. Three patients are disease-free transplant survivors without graft-versus-host disease after 46, 34, and 16 months.
Llano
Oscar Gonzalez
OG
Pediatric Department and Hematology Service, School of Medicine and University Hospital, "Dr. Jose E. Gonzalez," Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. ogzzll25@hotmail.com
Perez
José Carlos Jaime
JC
Rodriguez
Olga Cantu
OC
Guerra
Consuelo Mancias
CM
Aguirre
Homero Gutiérrez
HG
Garza
Jose Luis Herrera
JL
Rodriguez-Romo
Laura
L
Almaguer
David Gomez
DG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D006402:Hematologic Diseases / Q000150:complications / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008558:Melphalan / Q000008:administration & dosage; D008800:Mexico; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine; D008558:Melphalan