Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug.
Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).
Park
Hwa Young
HY
Department of Advanced Materials, Hannam University, 461-6 Jeonmin Dong, Yususng, Daejeon, Korea.
Oh
Keun Sang
KS
Koo
Hyoung Mo
HM
Cho
Sun Hang
SH
Chung
Sang Jun
SJ
Lim
Yong Taik
YT
Kim
Dongmin
D
Yuk
Soon Hong
SH
D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003511:Cyclohexanols / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D006493:Heparin / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008863:Microspheres; D020442:Poloxamer / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D003692:Delayed-Action Preparations; D020442:Poloxamer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000069470:Venlafaxine Hydrochloride; D011142:Polyvinyl Alcohol; D006493:Heparin