title: Association of leptin receptor polymorphisms Lys109Arg and Gln223Arg with serum leptin profile and bone mineral density in Korean women.
abstract: OBJECTIVE
  The objective of the study was to examine the relationship of the LEPR Lys109Arg and Gln223Arg polymorphisms and the serum leptin profile and bone mineral density (BMD).
  
  
  METHODS
  Cross-sectional study on a cohort of 145 premenopausal and 118 postmenopausal Korean women. The BMDs and serum levels of leptin, the soluble leptin receptor (sLR), and estradiol were measured, and the LEPR gene was genotyped.
  
  
  RESULTS
  The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively. Premenopausal subjects carrying the Lys109 allele had a higher total hip BMD (P = .044) and showed a nonsignificant trend toward a higher femoral neck and lumbar BMD than the subjects without this allele.
  
  
  CONCLUSIONS
  Our study suggests the LEPR Lys109Arg polymorphism is one of the genetic determinants of the peak bone mass in Korean women.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Sun Mie
authors.initials: SM
authors.lastname: Kim
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jung Ryeol
authors.initials: JR
authors.lastname: Lee
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Seung-Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D000483:Alleles; D001837:Body Weights and Measures; D015519:Bone Density / Q000235:genetics*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D007723:Korea; D020738:Leptin / Q000097:blood* / Q000235:genetics; D008239:Lysine / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017698:Postmenopause; D017697:Premenopause; D054411:Receptors, Leptin / Q000235:genetics*
chemical_list: D020738:Leptin; D054411:Receptors, Leptin; D004958:Estradiol; D008239:Lysine; D005998:Glycine