title: Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug.
abstract: Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).
authors.affiliation: Department of Advanced Materials, Hannam University, 461-6 Jeonmin Dong, Yususng, Daejeon, Korea.
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Park
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.forename: Hyoung Mo
authors.initials: HM
authors.lastname: Koo
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Chung
authors.forename: Yong Taik
authors.initials: YT
authors.lastname: Lim
authors.forename: Dongmin
authors.initials: D
authors.lastname: Kim
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
mesh_terms: D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003511:Cyclohexanols / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D006493:Heparin / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008863:Microspheres; D020442:Poloxamer / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D003692:Delayed-Action Preparations; D020442:Poloxamer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000069470:Venlafaxine Hydrochloride; D011142:Polyvinyl Alcohol; D006493:Heparin