title: Health-related quality of life in patients with systemic lupus erythematosus and its relationship with cyclophosphamide pulse therapy.
abstract: OBJECTIVE
  To examine health-related quality of life in Brazilian patients with systemic lupus erythematosus (SLE) and compare patients using cyclophosphamide (CP) pulse therapy with those who do not use it.
  
  
  METHODS
  Patients with SLE using or not CP completed the SF-36 and SRQ-20 (psychological morbidity) questionnaire. The Lupus Activity Criteria Count (LAAC) assessed SLE disease activity.
  
  
  RESULTS
  We studied 102 patients with SLE. The presence of psychological morbidity was associated with all the scores from SF-36. The physical component summary (PCS) of the SF-36 was significantly lower in patients with activity disease and the mental component summary (MCS) was significantly lower in the patients with psychological morbidity. Comparing patients using or not CP, it was not observed in a statistical significant difference in the 8 domains of the SF-36, nor in the PCS and MCS between the two groups. The prevalence of psychological morbidity evaluated by the SRQ-20 has not presented a statistical significant difference between the patients using or not CP. In the multivariate analysis, using the PCS and MCS as separate dependent variables, the most important variable associated with them was psychological morbidity.
  
  
  CONCLUSIONS
  Cyclophosphamide pulse therapy does not worse health-related quality of life in patients with SLE. The presence of psychological distress is an important factor associated with worse quality of life.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil. mmcmedeiros@hotmail.com
authors.forename: Marta Maria C
authors.initials: MM
authors.lastname: Medeiros
authors.forename: Ana Paula T
authors.initials: AP
authors.lastname: Menezes
authors.forename: Virgínia Angélica
authors.initials: VA
authors.lastname: Silveira
authors.forename: Fernanda Nogueira H
authors.initials: FN
authors.lastname: Ferreira
authors.forename: George Rafael
authors.initials: GR
authors.lastname: Lima
authors.forename: Rozana Mesquita
authors.initials: RM
authors.lastname: Ciconelli
mesh_terms: D000328:Adult; D001938:Brazil; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008297:Male; D020551:Pulse Therapy, Drug; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide