Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus.
Two sesquiterpenes, corymbolone and mustakone, isolated from the chloroform extract of the rhizomes of Cyperus articulatus, exhibited significant anti-plasmodial properties. Mustakone was approximately ten times more active than corymbolone against the sensitive strains of the Plasmodium falciparum.
Rukunga
G M
GM
Kenya Medical Research Institute (KEMRI), PO BOX 54840, Nairobi, Kenya. grukunga@kemri.org
Muregi
F W
FW
Omar
S A
SA
Gathirwa
J W
JW
Muthaura
C N
CN
Peter
M G
MG
Heydenreich
M
M
Mungai
G M
GM
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029786:Cyperus; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes