title: High birth weight as an important risk factor for infant leukemia.
abstract: In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P trend<0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% CI: 1.02-1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.
authors.affiliation: National School of Public Health/FIOCRUZ, Rua Leopoldo Bulhões, 1480, Rio de Janeiro, RJ 21041-210, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Koifman
authors.forename: M S
authors.initials: MS
authors.lastname: Pombo-de-Oliveira
mesh_terms: D001724:Birth Weight; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology*; D016017:Odds Ratio; D012307:Risk Factors