[APC resistance due to factor V Leiden mutation presenting as acute hemorrhagic jejunal infarction--case report].
We report on a 43-year-old patient presenting to the emergency department with acute abdominal pain the source of which turned out to be acute hemorrhagic jejunal infarction due to portal and mesenteric vein occlusion with no apparent cause. In spite of a lacking history of hereditary thrombophilic risk factors, further diagnostic procedures revealed heterozygous factor V Leiden mutation. Diagnosis, therapy and clinical course are described. An overview on acute mesenteric venous occlusion with special reference to genetically determined thrombophilic disorders is given.
Garlipp
B
B
Abteilung für Allgemein-, Viszeral- und Unfallchirurgie, Park-Klinik Weissensee, Berlin. garlipp@park-klinik.com
Gerhardt
U
U
Linke
J
J
Arlt
G
G
D000006:Abdomen, Acute / Q000209:etiology; D020016:Activated Protein C Resistance / Q000150:complications / Q000209:etiology / Q000235:genetics*; D000208:Acute Disease; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005500:Follow-Up Studies; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007238:Infarction / Q000235:genetics* / Q000601:surgery; D007582:Jejunostomy; D007583:Jejunum / Q000098:blood supply* / Q000601:surgery*; D007813:Laparotomy; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics*; D008642:Mesenteric Veins; D017354:Point Mutation; D011169:Portal Vein; D011182:Postoperative Care; D011860:Radiography, Abdominal; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*
D006495:Heparin, Low-Molecular-Weight; C095381:factor V Leiden; D005165:Factor V