title: Hepatocellular carcinoma presenting as neutrophilic leukaemoid reaction--a rare entity.
abstract: Leukaemoid reaction is a rare, growth factor-driven, paraneoplastic manifestation of hepatocellular carcinoma. It may masquerade as the neutrophilic chronic myeloid leukaemia or as chronic neutrophilic leukaemia. A 52-year-old male presented with hepatosplenomegaly and severe leucocytosis. He had progressive leucocytosis, neutrophil alkaline phosphatase score elevated, liver function tests altered. FNAC from the mass in the liver revealed features of moderately differentiated hepatocellular carcinoma. The patient deteriorated within two weeks and died thereafter.
authors.affiliation: Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005.
authors.forename: Vijai
authors.initials: V
authors.lastname: Tilak
authors.forename: Madhukar
authors.initials: M
authors.lastname: Rai
authors.forename: V P
authors.initials: VP
authors.lastname: Singh
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Rai
authors.forename: Rajiva
authors.initials: R
authors.lastname: Raman
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007955:Leukemoid Reaction / Q000175:diagnosis* / Q000473:pathology; D007964:Leukocytosis / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils
chemical_list: D000469:Alkaline Phosphatase