Metabotropic glutamate receptor agonists for schizophrenia.
A drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.
Harrison
Paul J
PJ
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000077152:Olanzapine; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D018094:Receptors, Metabotropic Glutamate; D001569:Benzodiazepines; D000077152:Olanzapine