Mechanisms of regulation of hemopoiesis during experimental cytostatic myelosuppression induced by carboplatin.
The mechanisms of suppression and recovery of the bone marrow erythroid stem were studied on the model of myelosuppression induced by administration of carboplatin in the maximum tolerated dose. Single administration of the cytostatic led to the development of long-term hypoplasia of hemopoiesis. Despite enhanced proliferation of erythroid precursor caused by increased erythropoietic activity of blood plasma and bone marrow cells, inhibition of cell maturation prevented recovery of the content of morphologically recognizable erythrokaryocytes in the bone marrow.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Materia Medica Holding Research-and-Production Company, Moscow, Russia.
Zhdanov
V V
VV
Zyuz'kov
G N
GN
Udut
E V
EV
Simanina
E V
EV
Gur'yantseva
L A
LA
Khrichkova
T Yu
TY
Stavrova
L A
LA
Epshtein
O I
OI
Sergeeva
S A
SA
Gol'dberg
E D
ED
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D016190:Carboplatin / Q000633:toxicity*; D004921:Erythropoietin / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA
D000970:Antineoplastic Agents; D004921:Erythropoietin; D016190:Carboplatin