title: Comparison of umbilical cord interleukin-6 in preterm infants with premature rupture of membranes and intact membranes.
abstract: OBJECTIVE
  To compare inflammatory mediators in the cord blood of premature newborn infants with premature rupture of membranes (PROM) and intact membranes.
  
  
  METHODS
  Eighty-nine premature neonates with gestational age of 27-34 weeks that delivered in Ghaem Hospital in Mashhad, Iran from June 2005 to March 2006 were enrolled in a prospective observational study, and their umbilical cord plasma was collected at birth. They were allocated into 2 groups (45 patients with PROM, and 44 neonates with intact membranes). Interleukin-6 (IL-6) and C-reactive protein (CRP) levels were measured in cord plasma by the enzyme linked immunoassay (ELISA) method.
  
  
  RESULTS
  Mean cord plasma IL-6 levels in preterm neonates with PROM was 205.71 pg/ml, and in neonates with intact membranes was 33.3 pg/ml for IL-6 (p=0.000). The mean cord blood CRP level in newborns with PROM was 10.2 microgram/ml, and in those with intact membranes was 1.6 microgram/ml (p=0.41). Early onset sepsis was more frequent in infants with PROM than premature infants with intact membrane (38% versus 10%, p=0.001). In neonates with PROM, the mean cord blood IL-6 level was significantly higher in septic newborns (414.28 verus 40.44 pg/ml, p=0.000).
  
  
  CONCLUSIONS
  The premature newborn infants with PROM had increased IL-6 levels in cord blood, which was significantly higher in neonates that developed early onset sepsis.
authors.affiliation: Department of Neonatology, Tabriz University of Medical Sciences, Tabriz, Iran. gharehbaghimm@yahoo.com
authors.forename: Manizheh M
authors.initials: MM
authors.lastname: Gharehbaghi
authors.forename: Ali
authors.initials: A
authors.lastname: Peirovifar
authors.forename: Parvin M
authors.initials: PM
authors.lastname: Gharehbaghi
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000209:etiology
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein