Relationship between plasma B-type natriuretic peptide and ventricular function in adult cardiac surgery patients.
Plasma concentrations of B-type natriuretic peptide (BNP) were analysed during the peri- and post-operative periods in cardiac surgery patients, and the relationship between plasma BNP concentrations and various clinical parameters was explored. Thirty patients (17 women, 13 men) of age 54.5 +/- 17.1 years undergoing cardiac surgery between June 2004 and March 2005 were enrolled. Plasma BNP concentrations were measured pre-operatively, immediately post-operatively, and on the first, second, fourth and seventh post-operative days. On the first post-operative day, the BNP level was significantly increased but levels returned to baseline values by the seventh post-operative day. The pre-operative BNP level correlated with left ventricular ejection fraction and age, and the level 24 h after surgery correlated with left ventricular end-diastolic dimension and pre-operative BNP levels. These results showed that the plasma BNP concentration becomes markedly and acutely elevated after cardiac surgery, reflecting temporary ventricular dysfunction.
Jeong
D S
DS
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Chongno-gu, Seoul, Korea.
Kim
K-H
KH
Kim
C Y
CY
Kim
J S
JS
D006348:Cardiac Surgical Procedures; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D019990:Perioperative Care; D011184:Postoperative Period; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000503:physiopathology
D020097:Natriuretic Peptide, Brain