Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test.
The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.
Brański
Piotr
P
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Palucha
Agnieszka
A
Szewczyk
Bernadeta
B
Wierońska
Joanna M
JM
Pilc
Andrzej
A
Nowak
Gabriel
G
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D013550:Swimming; D013873:Thionucleotides / Q000494:pharmacology
D000928:Antidepressive Agents; D004791:Enzyme Inhibitors; D013873:Thionucleotides; D015124:8-Bromo Cyclic Adenosine Monophosphate; C016957:adenosine-3',5'-cyclic phosphorothioate; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases