Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination.
Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28+/CD23+ and CD28+/HLA-DR+, respectively). Up-regulation of Fcgamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine.
Martins
Marina Angela
MA
Laboratório de Biomarcadores de Diagnóstico e Monitoração, Instituto René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Barro Preto 30190-002, Belo Horizonte, MG, Brazil.
Silva
Maria Luiza
ML
Elói-Santos
Silvana Maria
SM
Ribeiro
José Geraldo Leite
JG
Peruhype-Magalhães
Vanessa
V
Marciano
Ana Paula Vieira
AP
Homma
Akira
A
Kroon
Erna Geessien
EG
Teixeira-Carvalho
Andréa
A
Martins-Filho
Olindo Assis
OA
D000328:Adult; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D017452:Receptors, IgG / Q000378:metabolism; D053701:Receptors, Interleukin-10 / Q000378:metabolism; D015854:Up-Regulation; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D015004:Yellow Fever / Q000276:immunology* / Q000517:prevention & control; D022341:Yellow Fever Vaccine / Q000008:administration & dosage / Q000276:immunology; D015005:Yellow fever virus / Q000276:immunology*
D017452:Receptors, IgG; D053701:Receptors, Interleukin-10; D014613:Vaccines, Attenuated; D022341:Yellow Fever Vaccine