Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study.
The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of Sub-Group 3 (controls).
Bagan
Jose V
JV
Oral Medicine, Valencia University, Department of Stomatology, University General Hospital, Valencia, Spain. bagan@uv.es
Jiménez
Yolanda
Y
Murillo
Judith
J
Poveda
Rafael
R
Díaz
José M
JM
Gavaldá
Carmen
C
Margaix
María
M
Scully
Crispian
C
Alberola
Trinidad M
TM
Torres Puente
Manuela
M
Pérez Alonso
Manuel
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000821:virology*