title: Reduced sensitivity of influenza A (H5N1) to oseltamivir.
abstract: We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.
authors.affiliation: CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia. jennifer.mckimm-breschkin@csiro.au
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McKimm-Breschkin
authors.forename: Paul W
authors.initials: PW
authors.lastname: Selleck
authors.forename: Tri Bhakti
authors.initials: TB
authors.lastname: Usman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Johnson
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D053139:Oseltamivir / Q000494:pharmacology*; D012794:Sialic Acids / Q000494:pharmacology; D053243:Zanamivir / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D012794:Sialic Acids; C081427:4-amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid; D053139:Oseltamivir; D053243:Zanamivir