title: Synthetic efforts toward the macrolactone core of Leucascandrolide A.
abstract: A chemoselective synthesis of 1, the macrocyclic core of leucascandrolide A, has been achieved by utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone, and olefin metatheses as the key steps.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Ferrié
authors.forename: Lucie
authors.initials: L
authors.lastname: Boulard
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pradaux
authors.forename: Samir
authors.initials: S
authors.lastname: Bouzbouz
authors.forename: Sébastien
authors.initials: S
authors.lastname: Reymond
authors.forename: Patrice
authors.initials: P
authors.lastname: Capdevielle
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C408748:leucascandrolide A