title: Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives.
abstract: New series of selenolo[2,3-c]pyridazine and pyrimido[4',5':4,5]selenolo[2,3-c] pyridazine derivatives were prepared from new 4-cyano-5,6-diphenylpyridazine-3(2H)selenone (2). Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data confirmed the structure of the newly synthesized compounds. Some selected compounds 2, 4a,b, 6a-c, and 11a were investigated for their anti-inflammatory activity. Compounds 4b and 6a-c which showed activity comparable to the standard drug Indomethacin were screened for their analgesic activity. In addition, the most active compounds were tested for their acute toxicity. Moreover, some of the tested compounds 4b, 6a, 6b and 6c were screened for their antibacterial and antifungal activities.
authors.affiliation: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt. sabdel68@yahoo.co.uk
authors.forename: Sh H
authors.initials: ShH
authors.lastname: Abdel-Hafez
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007249:Inflammation / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D006571:Heterocyclic Compounds; D016566:Organoselenium Compounds