Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma.
The INK4a/ARF locus encodes two different proteins, p16INK4a and p14ARF, which are crucial for two tumor suppressor pathways. We found that p14ARF mRNA expression was suppressed in 13 of 37 cases, among which 9 cases showed the inactivation of both of p14ARF and p16INK4a, and 4 cases showed the inactivation of p14ARF alone. The inactivation of p14ARF and the mutation of p53 are mutually exclusive. The patients with the p14ARF inactivation had shorter survival, similar to that of patients with the p53 mutation. These results indicate that the inactivation of p14ARF plays a key role in the progression of ATLL.
Kohno
Tomoko
T
Division of Cytokine Signaling, Department of Molecular Microbiology and Immunology, Nagasaki University, Graduate School of Biomedical Science, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. tomoko@net.nagasaki-u.ac.jp
Yamada
Yasuaki
Y
Tawara
Masayuki
M
Takasaki
Yumi
Y
Kamihira
Shimeru
S
Tomonaga
Masao
M
Matsuyama
Toshifumi
T
D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D018450:Disease Progression; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D009154:Mutation; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D015996:Survival Rate; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism*
D019941:Cyclin-Dependent Kinase Inhibitor p16; D012333:RNA, Messenger; D025803:Tumor Suppressor Protein p14ARF