title: Benefit of mediastinal and para-aortic lymph-node dissection for advanced gastric cancer with esophageal invasion.
abstract: OBJECTIVE
  Lymph-node dissection in gastric cancers with esophageal invasion (AGCE) is of current interest. This study examined the significance of inferior mediastinal lymph-node (IM) and para-aortic lymph-node (PA) dissection for this type of cancer.
  
  
  METHODS
  Two hundred and seventy cases of AGCE were clinicopathologically reviewed. An index of estimated benefit from lymph-node dissection (IEBLD) was calculated from the frequency of lymph node metastasis in IM and PA, and from 5-year survival rates for metastatic cases.
  
  
  RESULTS
  Among the cases of AGCE, IM and PA metastasis rates were 18.1% and 22.2%, respectively. The IEBLD for IM and PA was similar to that for dissection of the second-tier lymph nodes around the celiac axis. The IM metastasis rate was 0.0% for esophageal invasion of 0-9 mm, 2.2% for 10-19 mm, 17.8% for 20-29 mm, and 21.7% for 30-39 mm of esophageal invasion.
  
  
  CONCLUSIONS
  AGCE is associated with a high rate of PA metastasis, and with a high rate of IM metastasis when esophageal invasion exceeds 2 cm. Since dissection of IM and PA achieved the same benefit as dissection of second-tier lymph nodes, we recommend thorough dissection of these lymph nodes.
authors.affiliation: Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan. sonunobe@cick.jp
authors.forename: Souya
authors.initials: S
authors.lastname: Nunobe
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Ohyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonoo
authors.forename: Naoki
authors.initials: N
authors.lastname: Hiki
authors.forename: Tetsu
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Seto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D001012:Aorta, Abdominal; D002277:Carcinoma / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000473:pathology*