title: Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
abstract: The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
authors.affiliation: Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Pradeep S
authors.initials: PS
authors.lastname: Pallan
authors.forename: Damian
authors.initials: D
authors.lastname: Ittig
authors.forename: Annie
authors.initials: A
authors.lastname: Héroux
authors.forename: Zdzislaw
authors.initials: Z
authors.lastname: Wawrzak
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Leumann
authors.forename: Martin
authors.initials: M
authors.lastname: Egli
mesh_terms: D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D015032:Zinc / Q000737:chemistry
chemical_list: D004247:DNA; D015032:Zinc