[Advances in the studies of miRNAs and cell apoptosis].
MicroRNAs (miRNAs) are a recently discovered class of 18 - 24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16.
Guo
Ling
L
Southern Medical University, Department of Radiation Medicine, Guangzhou 510515, China.
Ding
Zhen-Hua
ZH
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*
D035683:MicroRNAs