title: Theory and generalization of Monte Carlo models of the BOLD signal source.
abstract: The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics.
authors.affiliation: Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Sheffield, UK.
authors.forename: John
authors.initials: J
authors.lastname: Martindale
authors.forename: Aneurin J
authors.initials: AJ
authors.lastname: Kennerley
authors.forename: David
authors.initials: D
authors.lastname: Johnston
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: John E
authors.initials: JE
authors.lastname: Mayhew
mesh_terms: D006439:Hemodynamics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009010:Monte Carlo Method; D010100:Oxygen / Q000097:blood*; D019047:Phantoms, Imaging
chemical_list: D010100:Oxygen