The expression of TNF-alpha and ICAM-1 in lesions of lichen planus and its implication.
In order to investigate the role of TNF-and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.
Chen
Xu'e
X
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan, 430022, China. CXE911@hotmail.com
Liu
Zhixiang
Z
Yue
Qing
Q
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008010:Lichen Planus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1