title: Higher post-absorptive skeletal muscle LPL activity in African American vs. non-Hispanic White pre-menopausal women.
abstract: OBJECTIVE
  Higher post-absorptive post-heparin plasma lipoprotein lipase (LPL) activity has been reported in African Americans as compared to non-Hispanic whites but differences in tissue-specific LPL activity are unclear.
  
  
  METHODS
  Post-absorptive skeletal muscle (SM)-LPL (vastus lateralis ) and subcutaneous abdominal adipose tissue (AT)-LPL activity was measured in overweight, sedentary African American females (n = 11) as well as in their non-Hispanic white counterparts (n = 6) during a period of controlled low fat (30%) diet (for 10 days) combined with physical activity (for days 8-10). Post-absorptive substrate utilization was measured on day 10; fasting blood levels and SM and AT biopsies were obtained on day 11.
  
  
  RESULTS
  African Americans had significantly greater post-absorptive SM-LPL activity (P = 0.04) when compared to non-Hispanic whites. There were no significant differences in post-absorptive AT-LPL activity, free fatty acids, and systemic fat oxidation or respiratory quotient between African American and white non-Hispanic women in this study (P > 0.2 for all).
  
  
  CONCLUSIONS
  During a controlled low fat (30%) diet post-absorptive vastus lateralis SM-LPL activity is higher in sedentary pre-menopausal African American as compared to non-Hispanic white women.
authors.affiliation: New York Obesity Research Center, St. Luke's Hospital, Columbia University, New York, New York, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Berk
authors.forename: Julia A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Mijeong
authors.initials: M
authors.lastname: Lee
authors.forename: Kuan
authors.initials: K
authors.lastname: Zhang
authors.forename: Carol N
authors.initials: CN
authors.lastname: Boozer
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Pi-Sunyer
authors.forename: Susan K
authors.initials: SK
authors.lastname: Fried
authors.forename: Jeanine B
authors.initials: JB
authors.lastname: Albu
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology / Q000473:pathology; D000328:Adult; D001741:Black or African American / Q000208:ethnology*; D001706:Biopsy; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008875:Middle Aged; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000473:pathology; D050177:Overweight / Q000201:enzymology* / Q000208:ethnology; D019518:Postprandial Period; D017697:Premenopause / Q000208:ethnology / Q000378:metabolism*; D044465:White People / Q000208:ethnology*
chemical_list: D008071:Lipoprotein Lipase