title: Chemical and antibacterial constituents of Skimmia anquetelia.
abstract: Investigation of the leaves of Skimmia anquetelia (Rutaceae) led to the isolation of a new coumarin glucoside 7,8-dihdroxy-6-[3'-beta- D-glucopyranosyloxy-2'(xi)-hydroxy-3'-methylbutyl]-coumarin ( 1) together with five known coumarins: 6-(2,3-dihydroxy-3-methylbutyl)-7-methoxycoumarin ( 2), skimmin ( 3), osthol ( 4), esculetin ( 5) and scopuletin ( 6). The antibacterial activity of compounds 1 and 3 was also investigated against the plant bacterial pathogens Agrobacterium tumifaciens, Pseudomonas syringae and Pactobacterium carotovorum. Structures were determined on the basis of analyses of spectral evidence including 1D, 2 D NMR (COSY, HMQC, HMBC and NOESY) and mass spectroscopy.
authors.affiliation: Department of Chemistry, HNB Garhwal University, Srinagar (Garhwal), Uttarakhand, India.
authors.forename: Rajni Kant
authors.initials: RK
authors.lastname: Sharma
authors.forename: Devendra Singh
authors.initials: DS
authors.lastname: Negi
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D010936:Plant Extracts; D000432:Methanol