A case of concomitant polymorphism and spontaneous resolution: the tetragonal phase of 5-hydroxymethyl-7,7,N-trimethyl-6-oxabicyclo[3.2.1]octane-1-carboxamide.
The title compound, C(12)H(21)NO(3), crystallizes in two polymorphic forms, viz. the tetragonal form described here and the monoclinic form described previously [Foces-Foces, López-Rodríguez, Pérez, Martín & Pérez-Hernández (2007). Cryst. Growth Des. 7, 905-911]. The differences in the conformations of the hydroxymethyl and methylaminocarbonyl substituents have important consequences in the hydrogen-bond interaction motifs and, therefore, in the packing arrangements. These forms are concomitant polymorphs with melting points differing by 3 K.
Foces-Foces
C
C
Instituto Rocasolano, CSIC, Departamento de Cristalografía, Serrano 119, E-28006 Madrid, Spain. cfoces@iqfr.csic.es
López-Rodríguez
M
M
Pérez
C
C
D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D006860:Hydrogen Bonding; D008968:Molecular Conformation
C527870:5-hydroxymethyl-7,7,N-trimethyl-6-oxabicyclo(3.2.1)octane-1-carboxamide; D001643:Bridged Bicyclo Compounds; D006574:Heterocyclic Compounds, 2-Ring