Modulation of Abeta-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts.
Some evidences have demonstrated the participation of estrogen receptors (ERs) in rapid, non-genomic actions of estrogen to promote neuroprotection against different toxic agents. However, there is still very little information about the structural nature of these receptors and the manner these proteins may be integrated into the plasma membrane. One of the plausible possibilities is that they may be localized in lipid rafts microstructures where they would be associated with other, still unknown, molecules which may modulate their physiological activities related to cell survival. In this work, we have identified in caveolar fractions of murine septal and hippocampal neurons a membrane-related ER shown to physically interact with, both, a voltage-dependent anion channel and scaffold protein caveolin-1.
Marin
Raquel
R
Laboratory of Cellular Neurobiology, Department of Physiology & Institute of Biomedical Technologies, University of La Laguna, School of Medicine, Santa Cruz de Tenerife, Spain. rmarin@ull.es
Ramírez
Cristina
C
Morales
Araceli
A
González
Miriam
M
Alonso
Rafael
R
Díaz
Mario
M
D000818:Animals; D000838:Anions / Q000378:metabolism; D051242:Caveolin 1 / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D002470:Cell Survival; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008024:Ligands; D021962:Membrane Microdomains / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D000838:Anions; D051242:Caveolin 1; D047628:Estrogen Receptor alpha; D008024:Ligands