The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells.
The knockdown of PR-B by siRNA resulted in a significant increase in proliferation in an immortalized endometrial stromal cell line. This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis.
Wu
Yan
Y
Taussig Cancer Center, Center for Hematology and Oncology Molecular Therapeutics, Cleveland, Ohio, USA.
Shi
Xuerong
X
Guo
Sun-Wei
SW
D002460:Cell Line; D049109:Cell Proliferation; D004717:Endometrium / Q000166:cytology* / Q000502:physiology*; D005260:Female; D020868:Gene Silencing / Q000502:physiology; D006801:Humans; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology
D011980:Receptors, Progesterone; C097314:progesterone receptor B