Gene expression dynamics in the macrophage exhibit criticality.
Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are propagated over long temporal or spatial scales. Criticality enables the coordination of complex macroscopic behaviors that strike an optimal balance between stability and adaptability. It has long been hypothesized that biological systems are critical. Here, we address this hypothesis experimentally for system-wide gene expression dynamics in the macrophage. To this end, we have developed a method, based on algorithmic information theory, to assess macrophage criticality, and we have validated the method on networks with known properties. Using global gene expression data from macrophages stimulated with a variety of Toll-like receptor agonists, we found that macrophage dynamics are indeed critical, providing the most compelling evidence to date for this general principle of dynamics in biological systems.
Nykter
Matti
M
Institute of Signal Processing, Tampere University of Technology, 33101 Tampere, Finland.
Price
Nathan D
ND
Aldana
Maximino
M
Ramsey
Stephen A
SA
Kauffman
Stuart A
SA
Hood
Leroy E
LE
Yli-Harja
Olli
O
Shmulevich
Ilya
I
D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D015870:Gene Expression; D008264:Macrophages / Q000378:metabolism*; D051379:Mice