title: Transgenic fish resistant to infectious diseases, their risk and prevention of escape into the environment and future candidate genes for disease transgene manipulation.
abstract: Transgenic fish have been produced that have improved growth, disease resistance, survival in cold and body composition, have altered color, that can act as bioindicators for estrogenic pollutants and that can produce pharmaceutical proteins. The largest amount of transgenic research has focused on growth hormone transfer. A relatively small amount of research has focused on enhancing disease resistance, but significant enhancement has been accomplished. Pleiotropic effects from the transfer of other transgenes, particularly growth hormone gene can alter disease resistance in both positive and negative ways. Most negative effects for all transgenes appear to lower fitness traits, which is positive for biological containment. Transgenic fish appear to pose little environmental risk, but this research is not fully conclusive. To expedite commercialization and minimize environmental risk, transgenic sterilization research is underway. A large amount of functional genomics research has resulted in a much better understanding of gene expression when fish are experiencing disease epizootics. This information may allow the future design of more effective transgenic approaches to address disease resistance.
authors.affiliation: Department of Fisheries and Allied Aquacultures, Auburn University, Alabama 36849, USA. dunhara@auburn.edu
authors.forename: Rex A
authors.initials: RA
authors.lastname: Dunham
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D017756:Aquaculture / Q000639:trends; D003141:Communicable Diseases / Q000235:genetics / Q000662:veterinary*; D005393:Fish Diseases / Q000235:genetics* / Q000382:microbiology / Q000821:virology; D005399:Fishes / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics; D007113:Immunity, Innate / Q000235:genetics*; D019076:Transgenes / Q000235:genetics*