title: [Onset of dopaminergic therapy in Parkinson's disease: six good reasons not to delay it].
abstract: Determining the point at which drug therapy with a dopaminergic agent should begin in a patient with early Parkinson disease is controversial. The current trend favors not indicating any drug until functional disability is present. However, the evolution demonstrated by patients included in different clinical trials indicates that delaying dopaminergic treatment is associated with worst outcome. In addition, there are other experimental and clinical data that support this idea. On the other side of the argument is the possibility that early use of drugs may inducing adverse effects in non-disabled patients.
authors.affiliation: Unidad de Neurología y Neurocirugía Funcional, Clínica Quirón, San Sebastián, Centro de Investigación Parkinson, Policlínica Guipuzkoa, Spain. glinazasoro@terra.es
authors.forename: G
authors.initials: G
authors.lastname: Linazasoro
mesh_terms: D003342:Corpus Striatum / Q000473:pathology; D018450:Disease Progression; D004298:Dopamine / Q000627:therapeutic use*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D004298:Dopamine