title: The naphthalene state of the science symposium: objectives, organization, structure, and charge.
abstract: This report provides a summary of the objectives, organization, structure and charge for the naphthalene state of the science symposium (NS(3)), Monterey, CA, October 9-12, 2006. A 1-day preliminary conference was held followed by a 3-day state of the science symposium covering four topics judged by the Planning Committee to be crucial for developing valid and reliable scientific estimates of low-dose human cancer risk from naphthalene. The Planning Committee reviewed the relevant scientific literature to identify singularly knowledgeable researchers and a pool of scientists qualified to serve as expert panelists. In two cases, independent scientists were commissioned to develop comprehensive reviews of the relevant science in a specific area for which no leading researcher could be identified. Researchers and expert panelists alike were screened for conflicts of interest. All policy issues related to risk assessment practices and risk management were scrupulously excluded. NS(3) was novel in several ways and provides an innovative model for the effective use of peer review to identify scientific uncertainties and propose research strategies for reducing or eliminating them prior to the conduct of risk assessment.
authors.affiliation: Scientific Peer Review Program, Regulatory Checkbook, P.O. Box 319, Mt. Vernon, VA 22121, USA. Belzer@regulatorycheckbook.org
authors.forename: Richard B
authors.initials: RB
authors.lastname: Belzer
authors.forename: James S
authors.initials: JS
authors.lastname: Bus
authors.forename: Ercole L
authors.initials: EL
authors.lastname: Cavalieri
authors.forename: Steven C
authors.initials: SC
authors.lastname: Lewis
authors.forename: D Warner
authors.initials: DW
authors.lastname: North
authors.forename: Richard C
authors.initials: RC
authors.lastname: Pleus
mesh_terms: D002274:Carcinogens, Environmental / Q000633:toxicity*; D003226:Congresses as Topic; D032921:Consensus; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D009281:Naphthalenes / Q000633:toxicity*; D010380:Peer Review / Q000379:methods*; D012107:Research Design; D018570:Risk Assessment / Q000379:methods / Q000458:organization & administration / Q000639:trends
chemical_list: D002274:Carcinogens, Environmental; D009281:Naphthalenes; C031721:naphthalene