title: Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.
abstract: Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin-(3',5'-diol) ( 1) and psoroxanthin ( 4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line).
authors.affiliation: Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. leetj@bms.com
authors.forename: John E
authors.initials: JE
authors.lastname: Leet
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
authors.forename: Dieter M
authors.initials: DM
authors.lastname: Drexler
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Cantone
authors.forename: Stella
authors.initials: S
authors.lastname: Huang
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Mamber
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Raouf
authors.initials: R
authors.lastname: Hussain
authors.forename: David J
authors.initials: DJ
authors.lastname: Newman
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002417:Cattle; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D008270:Madagascar; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones