DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer.
Oral health care professionals could drastically improve the quality of life for patients with potentially malignant oral lesions by using a noninvasive test that could be used to detect cancer using saliva. Promoter DNA hypermethylation is a critical step in oral carcinogenesis and has a number of significant advantages over genetic and protein diagnostic markers. Methylight is a recently developed assay that rapidly quantifies promoter hypermethylation and could potentially be applied into a clinical setting.
Viet
C T
CT
University of California, San Francisco, School of Dentistry, USA. chi.viet@ucsf.edu
Jordan
Richard C K
RC
Schmidt
Brian L
BL
D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000235:genetics; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D042241:Early Diagnosis; D017491:Genes, APC; D019942:Genes, p16; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D025521:Tumor Suppressor Proteins / Q000235:genetics
D014408:Biomarkers, Tumor; D015820:Cadherins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D047428:Protein Kinase Inhibitors; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes