title: [Case of acute respiratory failure caused by drug-induced lung injury by shiniseihaito].
abstract: We present a case of acute respiratory distress syndrome (ARDS) caused by allergic reactions to shiniseihaito. An 84-year-old woman showed acute interstitial pneumonia followed by ARDS after taking shiniseihaito for the treatment of rhinitis. The ARDS were markedly improved with corticosteroid therapy. This case was diagnosed as being induced by shiniseihaito because it was compatible with 4 of 5 of Camus's criteria. The stimulation index of the drug lymphocyte stimulation test with shiniseihaito increased after corticosteroid therapy had been tapered and suggested that the mechanism of acute interstitial pneumonia in this case was allergic reaction induced by shiniseihaito. This is the seventh reported case of drug induced lung injury by shiniseihaito. We recommend careful observation when this medicine is prescribed.
authors.affiliation: Department of Respiratory Medicine and Allergy, Nara Hospital, Kinki University School of Medicine.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakajima
authors.forename: Hirochiyo
authors.initials: H
authors.lastname: Sawaguchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Tsuji
authors.forename: Takeaki
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Shigenori
authors.initials: S
authors.lastname: Nakajima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tohda
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage; D008517:Phytotherapy / Q000009:adverse effects*; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D011239:Prednisolone; D008775:Methylprednisolone