Immunobiological specificity of antibodies against glutamate and gamma-aminobutyric acid.
Experiments on C57Bl/6 mice showed that chronic epileptization of the brain (pharmacological pentylenetetrazole kindling) is accompanied by induction of autoantibodies against glutamate and GABA. Immunohistochemical similarity of antibodies against glutamate and GABA was demonstrated. Study on the model of pentylenetetrazole-induced acute generalized epileptiform activity showed high immunobiological specificity of intraperitoneally injected antibodies against GABA and glutamate: antiepileptic effect of antiglutamate antibodies and proepileptic effect of antibodies against GABA.
Vetrile
L A
LA
Laboratory of Neuroimmunopathology, Laboratory of Epileptogenesis, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Karpova
M N
MN
Trekova
N A
NA
Kuznetsova
L V
LV
Klishina
N Yu
NY
Evseev
V A
VA
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000918:Antibody Specificity; D004797:Enzyme-Linked Immunosorbent Assay; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D005680:gamma-Aminobutyric Acid / Q000276:immunology*
D000906:Antibodies; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid