Thiosemicarbazones active against Clostridium difficile.
A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.
Costello
Cait
C
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
Karpanen
Tarja
T
Lambert
Peter A
PA
Mistry
Preena
P
Parker
Katy J
KJ
Rathbone
Daniel L
DL
Ren
Jiangmeng
J
Wheeldon
Laura
L
Worthington
Tony
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013882:Thiosemicarbazones