title: Tissue availability of afobazole and its major metabolites in rats.
abstract: Intraperitoneally injected afobazole and its major metabolites are intensively distributed in highly vascularized tissues of rats, including the liver, spleen, and kidneys; the content of these compounds in moderately and poorly vascularized tissues (muscles and mesentery) is much lower. Afobazole and its metabolites possess intermediate ability to penetrate into the brain.
authors.affiliation: Laboratory of Pharmacokinetics, V V Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A O
authors.initials: AO
authors.lastname: Viglinskaya
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: O Yu
authors.initials: OY
authors.lastname: Kravtsova
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001562:Benzimidazoles / Q000493:pharmacokinetics*; D001682:Biological Availability; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D009025:Morpholines / Q000493:pharmacokinetics*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines