Experimental thrombosis in rabbit marginal ear vein and evaluation of the thrombolytic action of longolytin.
A model of venous thrombosis on the rabbit marginal ear vein was developed. It is based on occlusion of a segment of the left or right ear vein followed by injection of thrombin into this segment. Thrombolytic activity of longolytin applied externally onto the thrombotic venous segment was evaluated. The drug 2-fold shortened the time of clot lysis and 4-4.5-fold increased the rate of thrombolysis. The effect of longolytin was potentiated by heparin. The rate of lysis was higher in large thrombi and in the left vein (effect of asymmetry).
Podorol'skaya
L V
LV
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University, Moscow, Russia.
Serebryakova
T N
TN
Sharkova
T S
TS
Neumyvakin
L V
LV
Khromov
I S
IS
Khokhlov
N V
NV
Tarantul
V Z
VZ
D000818:Animals; D004423:Ear / Q000098:blood supply*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011817:Rabbits; D013927:Thrombosis / Q000188:drug therapy*; D014680:Veins
D005343:Fibrinolytic Agents; D010447:Peptide Hydrolases; C037962:longolytin