title: Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers.
abstract: Sedimentation velocity experiments show that only monomers coexist with amyloid fibrils of human islet amyloid-polypeptide. No oligomers containing <100 monomers could be detected, suggesting that the putative toxic oligomers are much larger than those found for the Alzheimer's peptide, Abeta(1-42).
authors.forename: Sara M
authors.initials: SM
authors.lastname: Vaiana
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Ghirlando
authors.forename: Wai-Ming
authors.initials: WM
authors.lastname: Yau
authors.forename: William A
authors.initials: WA
authors.lastname: Eaton
authors.forename: James
authors.initials: J
authors.lastname: Hofrichter
mesh_terms: D000682:Amyloid / Q000032:analysis* / Q000737:chemistry*; D002498:Centrifugation / Q000379:methods*; D031521:Fractionation, Field Flow / Q000379:methods*; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008970:Molecular Weight; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000682:Amyloid; D058228:Islet Amyloid Polypeptide