title: Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis. 1989.
abstract: One hundred five patients were enrolled in a 12-week, randomized, prospective, double-blind, placebo-controlled trial of recombinant human gamma-interferon (rHu gamma-IFN) for the treatment of rheumatoid arthritis. Fifty-four patients received rHu gamma-IFN and 51 received placebo. Forty-two patients in each group completed the 12-week trial. Some clinical improvement occurred in both groups of patients. Although the improvement with rHu gamma-IFN was greater than that with placebo, the differences were generally not statistically significant.
authors.affiliation: Division of Rheumatology, University of Utah, Salt Lake City, UT 84132, USA.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Cannon
authors.forename: Seth H
authors.initials: SH
authors.lastname: Pincus
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Emkey
authors.forename: Alex
authors.initials: A
authors.lastname: Denes
authors.forename: Selwyn A
authors.initials: SA
authors.lastname: Cohen
authors.forename: Frederick
authors.initials: F
authors.lastname: Wolfe
authors.forename: P Anthony
authors.initials: PA
authors.lastname: Saway
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Jaffer
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Weaver
authors.forename: Lewis
authors.initials: L
authors.lastname: Cogen
authors.forename: John D
authors.initials: JD
authors.lastname: Schindler
mesh_terms: D018501:Antirheumatic Agents / Q000266:history* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000266:history*; D004311:Double-Blind Method; D049673:History, 20th Century; D006801:Humans; D007371:Interferon-gamma / Q000266:history* / Q000627:therapeutic use; D015337:Multicenter Studies as Topic / Q000266:history; D010919:Placebos; D016032:Randomized Controlled Trials as Topic / Q000266:history; D011994:Recombinant Proteins
chemical_list: D018501:Antirheumatic Agents; D010919:Placebos; D011994:Recombinant Proteins; D007371:Interferon-gamma