title: Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation.
abstract: OBJECTIVE
  We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy.
  
  
  METHODS
  We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour.
  
  
  CONCLUSIONS
  This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.
authors.affiliation: Department of Neurogenetics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: A C J
authors.initials: AC
authors.lastname: Ammerlaan
authors.forename: M P W A
authors.initials: MP
authors.lastname: Houben
authors.forename: C C
authors.initials: CC
authors.lastname: Tijssen
authors.forename: P
authors.initials: P
authors.lastname: Wesseling
authors.forename: T J M
authors.initials: TJ
authors.lastname: Hulsebos
mesh_terms: D000328:Adult; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008579:Meningioma / Q000235:genetics / Q000556:secondary*; D009154:Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D018335:Rhabdoid Tumor / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors