title: Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer.
  
  
  METHODS
  Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival.
  
  
  RESULTS
  Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival.
  
  
  CONCLUSIONS
  Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Services, University of California, San Francisco School of Medicine, Helen Diller Family Comprehensive Cancer Center, 94143-1702, USA. chanjohn@obgyn.ucsf.edu
authors.forename: John K
authors.initials: JK
authors.lastname: Chan
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kapp
authors.forename: Michael K
authors.initials: MK
authors.lastname: Cheung
authors.forename: Jacob Y
authors.initials: JY
authors.lastname: Shin
authors.forename: Deirdre
authors.initials: D
authors.lastname: Stieglitz
authors.forename: Amreen
authors.initials: A
authors.lastname: Husain
authors.forename: Nelson N
authors.initials: NN
authors.lastname: Teng
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Berek
authors.forename: Kathryn
authors.initials: K
authors.lastname: Osann
authors.forename: Hongyan
authors.initials: H
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000556:secondary; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D018426:SEER Program; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology