Two quinazolinones: a ring conformational study.
The molecules of (+/-)-2-(4-methoxyphenyl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(22)N(2)O(2), (I), and (+/-)-2-(1,3-benzodioxol-5-yl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(20)N(2)O(3), (II), have T-shaped forms in the crystal structure. The tetrahydropyrimidine ring in both structures adopts a sofa conformation. Both molecules are linked by N-H...O and C-H...O hydrogen bonds to form sheets built from alternating R(2)(2)(8) and R(4)(4)(26) [R(4)(4)(24) in (II)] edge-fused rings. Additionally, the structures are stabilized by extensive C-H...pi interactions.
Swamy
G Y S K
GY
Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology, Hyderabad 500 007, India. swamy@iict.res.in
Sridhar
B
B
Ravikumar
K
K
Sadanandam
Y S
YS
D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D052999:Quinazolinones / Q000737:chemistry*
D052999:Quinazolinones