Prognostic significance of the histomorphometric features of bone marrow trephine biopsies in patients with chronic myeloid leukemia.
OBJECTIVE
To study the correlation of histomorphometric data of bone marrow trephine biopsies at the time of initial diagnosis in chronic myeloid leukemia (CML) patients with the patient prognosis.


METHODS
A total of 40 CML patients were divided equally in group I (developed accelerated phase or blast crisis within 18 months of initial diagnosis of chronic phase of CML) and group II (developed accelerated phase or blast crisis > 30 months after initial diagnosis of chronic phase of CML). The clinical, hematologic and histomorphometric data were compared in the 2 groups of CML patients.


RESULTS
The percentage of bone marrow promyelocytes was significantly increased in group I. On morphometry, the number of blasts per square millimeter, the area of reticulin fibers per square millimeter and the percentage area occupied by reticulin fibers were statistically significant.


CONCLUSIONS
There seems to be grounds for hope for predicting prognosis of CML patients at initial diagnosis based on histomorphometric findings. The percentage area of reticulin fibers and the number of blasts per square millimeter are important prognostic predictors in histomorphometry data.
Lamba
Amit
A
Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dey
Pranab
P
Kumari
Savita
S
Marwaha
Neelam
N
D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000295:instrumentation / Q000379:methods; D001853:Bone Marrow / Q000473:pathology*; D004900:Erythroblasts / Q000473:pathology; D005260:Female; D042381:Granulocyte Precursor Cells / Q000473:pathology; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D019044:Image Cytometry; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D016014:Linear Models; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012155:Reticulin / Q000032:analysis; D012189:Retrospective Studies
D012155:Reticulin