title: GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise.
abstract: OBJECTIVE
  Increased physical activity is an integral part of weight loss programs in adolescents. We prospectively investigated the effects of exercise on glucagon-like peptide-1 (GLP-1) concentrations and on appetite markers.
  
  
  METHODS
  Normal weight (NW) and at risk of overweight/overweight (OW) male adolescents (n = 17/gr) underwent five consecutive days of aerobic exercise (1 h/day). A test meal was administered prior to the first exercise session and 36 hours following the last exercise session. GLP-1 and markers of appetite were assessed.
  
  
  RESULTS
  GLP-1 concentrations over the course of the test meal were lower in OW compared to NW boys (P < 0.05), while fasting GLP-1 concentrations tended to be lower in OW boys (0.05 < P < 0.1). Exercise caused an increase in the acute GLP-1 response to the liquid meal (from 52 to 78%, P = 0.02) that was similar in NW and OW adolescents. OW adolescents expressed greater restraint compared to NW adolescents (three-factor eating questionnaire, TFEQ) and there was a significant correlation between TFEQ for restraint score and BMI s.d. both before and after exercise intervention (P < 0.015). There was no significant correlation between markers of appetite and GLP-1 concentrations.
  
  
  CONCLUSIONS
  Lower concentrations of GLP-1, a satiety hormone, in OW compared to NW male adolescents support the theory that GLP-1 plays a role in the etiology of overweight. Whether the greater meal-induced, 0-30 min GLP-1 response following exercise is associated with increased satiety, a potentially beneficial effect of exercise, needs to be evaluated in larger studies. Obesity (2008) 16, 202-204. doi:10.1038/oby.2007.39.
authors.affiliation: Endocrinology and Diabetes Unit, British Columbia's Children's Hospital, University of British Columbia, Vancouver, Canada. jchanoine@cw.bc.ca
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Chanoine
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Mackelvie
authors.forename: Susan I
authors.initials: SI
authors.lastname: Barr
authors.forename: Alfred C K
authors.initials: AC
authors.lastname: Wong
authors.forename: Graydon S
authors.initials: GS
authors.lastname: Meneilly
authors.forename: Dariush H
authors.initials: DH
authors.lastname: Elahi
mesh_terms: D000293:Adolescent; D001066:Appetite / Q000502:physiology*; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000097:blood* / Q000502:physiology; D006306:Health Surveys; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology*; D010147:Pain Measurement; D011446:Prospective Studies; D012528:Satiety Response / Q000502:physiology*; D013851:Thinness / Q000503:physiopathology*
chemical_list: D052216:Glucagon-Like Peptide 1