title: RecO is essential for DNA damage repair in Deinococcus radiodurans.
abstract: Here we present direct evidence for the vital role of RecO in Deinococcus radiodurans's radioresistance. A recO null mutant was constructed using a deletion replacement method. The mutant exhibited a growth defect and extreme sensitivity to irradiation with gamma rays and UV light. These results suggest that DNA repair in this organism occurs mainly via the RecF pathway.
authors.affiliation: Key Laboratory of Chinese Ministry of Agriculture and Zhejiang Province for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Xu
authors.forename: Liangyan
authors.initials: L
authors.lastname: Wang
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Huiming
authors.initials: H
authors.lastname: Lu
authors.forename: Nanjiao
authors.initials: N
authors.lastname: Ying
authors.forename: Bing
authors.initials: B
authors.lastname: Tian
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Hua
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology; D004249:DNA Damage; D004260:DNA Repair; D034301:Deinococcus / Q000235:genetics* / Q000254:growth & development / Q000528:radiation effects; D005720:Gamma Rays; D009154:Mutation; D014466:Ultraviolet Rays
chemical_list: D001426:Bacterial Proteins