Two new coumarins from Herpetospermum caudigerum.
The ethyl acetate extract from the seeds of Herpetospermum caudigerum was found to show protective effects on carbon tetrachloride (CCl(4)) and thioacetamide (TAA)-induced acute hepatic injuries in mice. From the ethyl acetate extract, two new coumarins, herpetolide A (1) and herpetolide B (2), along with four known compounds, herpetone (3), dehydrodiconiferyl alcohol (4), 2,4-dihydroxypyrimidine (5) and stigmasterol (6) were isolated. The structures of the new coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury.
Zhang
Mei
M
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, PR China. zhangmei63@yahoo.com.cn
Deng
Yun
Y
Zhang
Hong-Bin
HB
Su
Xiao-Lin
XL
Chen
Hu-Lan
HL
Yu
Tian
T
Guo
Ping
P
D000085:Acetates; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D003374:Coumarins / Q000032:analysis* / Q000627:therapeutic use; D019662:Cucurbitaceae / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D012639:Seeds / Q000737:chemistry; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000085:Acetates; D003374:Coumarins; D012997:Solvents; C007650:ethyl acetate; D004121:Dimethyl Sulfoxide