title: Efficacy of He-Ne Laser in the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients.
abstract: OBJECTIVE
  The objective of this study was to evaluate the efficacy of low-level lasers for the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients.
  
  
  METHODS
  Twenty-four hospitalized patients with oral cancer, scheduled to undergo radiotherapy at KMC, Manipal, were enrolled in the present study and assigned to laser (Group I)/control group (Group II). They were treated using He-Ne laser (lambda = 632.8nm, output = 10 mW and energy density = 1.8 J/cm(2)). Patients were subjected to treatment using laser scanner for 8 days and subsequently were treated using laser probe at 6 anatomic sites in the oral cavity for 5 minutes each. The patients were evaluated on each day of treatment for pain severity (NRS), functional impairment (FIS), and oral mucositis (RTOG) and were followed until the end of cancer treatment. Statistical analysis was done using SPSS version 10.
  
  
  RESULTS
  Laser therapy applied prophylactically during radiotherapy can reduce the severity of oral mucositis, severity of pain, and functional impairment.
authors.affiliation: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Karnatka, India. drarora@gmail.com
authors.forename: Honey
authors.initials: H
authors.lastname: Arora
authors.forename: Keerthilatha M
authors.initials: KM
authors.lastname: Pai
authors.forename: Arun
authors.initials: A
authors.lastname: Maiya
authors.forename: M S
authors.initials: MS
authors.lastname: Vidyasagar
authors.forename: A
authors.initials: A
authors.lastname: Rajeev
mesh_terms: D016371:Cranial Irradiation / Q000009:adverse effects*; D004435:Eating; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000532:radiotherapy*; D054020:Lasers, Gas / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D052016:Mucositis / Q000209:etiology / Q000517:prevention & control / Q000532:radiotherapy; D010146:Pain / Q000517:prevention & control; D011446:Prospective Studies; D013280:Stomatitis / Q000209:etiology / Q000517:prevention & control* / Q000532:radiotherapy