The ygaVP genes of Escherichia coli form a tributyltin-inducible operon.
A tributyltin (TBT) luxAB transcriptional fusion in Escherichia coli revealed that a TBT-activated promoter is located upstream of two cotranscribed orphan genes, ygaV and ygaP. We demonstrate that transcription from the promoter upstream of ygaVP is constitutive in a ygaVP mutant, suggesting that YgaV is an autoregulated, TBT-inducible repressor.
Gueuné
Hervé
H
Université de Nantes, CNRS UMR 6144, GEPEA, ERT CBAC, Département Génie Biologique, 18 Bd. Gaston Defferre, 85035 La Roche sur Yon, France.
Durand
Marie-José
MJ
Thouand
Gérald
G
DuBow
Michael S
MS
D017766:Acid Anhydride Hydrolases / Q000235:genetics; D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D008969:Molecular Sequence Data; D009154:Mutation; D009876:Operon; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000494:pharmacology*
D029968:Escherichia coli Proteins; D012097:Repressor Proteins; D014220:Trialkyltin Compounds; C530142:YgaP protein, E coli; C530141:YgaV protein, E coli; C011559:tributyltin; D017766:Acid Anhydride Hydrolases; C526730:RppH protein, E coli