Antiarrhythmic activity of n-tyrosol during acute myocardial ischemia and reperfusion.
Antiarrhythmic activity of n-tyrosol was demonstrated on the model of early occlusion and reperfusion arrhythmia. The preparation reduces the incidence of ventricular tachycardia and fibrillation, increases the percent of animals without ventricular arrhythmia, and moderates the severity of developing ventricular arrhythmias.
Chernyshova
G A
GA
Department of Circulation Pharmacology, State Research Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Plotnikov
M B
MB
Smol'yakova
V I
VI
Golubeva
I V
IV
Aliev
O I
OI
Tolstikova
T G
TG
Krysin
A P
AP
Sorokina
I V
IV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D017180:Tachycardia, Ventricular / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol