Direct carbocyclization of aldehydes with alkynes: combining gold catalysis with aminocatalysis.
A combination of gold(I) complexes and amine bases catalyzes the 5-exo-dig cyclization of formyl alkynes. This direct alpha-functionalization of aldehydes with unactivated alkynes does not involve the use of preformed enol equivalents.
Binder
Jörg T
JT
Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
Crone
Benedikt
B
Haug
Timm T
TT
Menz
Helge
H
Kirsch
Stefan F
SF