title: [Evaluating the applicability of MoM in second trimester maternal serum to screening for Down's syndrome in Jiangsu province].
abstract: OBJECTIVE
  To study the applicability of MultiCalc software to prenatal screening of Down's syndrome in Jiangsu province, China.
  
  
  METHODS
  The gestational age-specific median of maternal serum marker was calculated by means of regression method. Regression functions for adjustment of Multiple of the Median (MoM) by weight were established for our own population.
  
  
  RESULTS
  Before the adjustment by weight, the average level of alpha fetal protein(AFP) was 16% higher and the free beta-human chorionic gonadotrophin (beta-hCG) was 14% higher than those of the Caucasian in MultiCalc software respectively. But when the AFP and free beta-hCG results were converted to weight-adjusted MoM levels, the values were 0.99 and 1.02 respectively. The median of MoM of AFP and the free beta-hCG were 1.00 through the regression model of gestational age and weight adjustment.
  
  
  CONCLUSIONS
  There was no difference of average weight-adjusted MoM levels between the Jiangsu population and the Caucasian, and the MultiCalc software was applicable to maternal serum screening for Down's syndrome of Jiangsu.
authors.affiliation: Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Bi-yun
authors.initials: BY
authors.lastname: Xu
authors.forename: Yali
authors.initials: Y
authors.lastname: Hu
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Zhang
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Qi-lan
authors.initials: QL
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Yue
authors.forename: Tong
authors.initials: T
authors.lastname: Ru
authors.forename: Zheng-feng
authors.initials: ZF
authors.lastname: Xu
authors.forename: Rui-fang
authors.initials: RF
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhong
authors.forename: Qing-mei
authors.initials: QM
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D001835:Body Weight; D002681:China; D006063:Chorionic Gonadotropin / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D008875:Middle Aged; D009035:Mothers; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood*; D011296:Prenatal Diagnosis / Q000379:methods*; D012016:Reference Values; D012044:Regression Analysis; D012984:Software; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins