title: Comparison of central venous to mixed venous oxygen saturation in patients with low cardiac index and filling pressures after coronary artery surgery.
abstract: OBJECTIVE
  To evaluate the correlation and agreement between mixed venous oxygen saturation (SvO(2)) and central venous oxygen saturation (ScvO(2)) in patients with low cardiac index and filling pressures after coronary artery surgery.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Tertiary care academic hospital.
  
  
  METHODS
  Sixty consecutive patients with a cardiac index <2 L/min/m(2) and a pulmonary artery occlusion pressure <12 mmHg after coronary artery surgery were included.
  
  
  METHODS
  Patients were monitored by a pulmonary artery catheter and a central venous catheter positioned in the superior vena cava.
  
  
  RESULTS
  SvO(2) and ScvO(2) were simultaneously measured before (T0) and after (T1) normalization of the cardiac index (>2.5 L/min/m(2)) by fluid therapy. Sixty pairs of measures were obtained at T0 and at T1. Bias between SvO(2) and ScvO(2) was -0.6% (T0) and -0.8% (T1). Limits of agreement were from -19.2% to 18% (T0) and from -15.6% to 14% (T1), and the correlation coefficient was 0.463 (T0) and 0.72 (T1). SvO(2) and ScvO(2) changes from T0 to T1 (DeltaSvO(2) and DeltaScvO(2)) were calculated. The bias between DeltaSvO(2) and DeltaScvO(2) was -0.25. Limits of agreement were from -20% to 19.5%, and the correlation coefficient was 0.6.
  
  
  CONCLUSIONS
  In patients with low cardiac index and filling pressures after coronary artery surgery, ScvO(2) could not be used as a direct alternative for SvO(2). After fluid therapy and normalization of the cardiac index, differences between individual values remained large, and the disagreement between ScvO(2) and SvO(2) changes was significant.
authors.affiliation: Department of Anesthesia and Surgical Intensive Care, Hotel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon. ritalama@idm.net.lb
authors.forename: Alexandre
authors.initials: A
authors.lastname: Yazigi
authors.forename: Claudine
authors.initials: C
authors.lastname: El Khoury
authors.forename: Samia
authors.initials: S
authors.lastname: Jebara
authors.forename: Fadia
authors.initials: F
authors.lastname: Haddad
authors.forename: Gemma
authors.initials: G
authors.lastname: Hayeck
authors.forename: Ghassan
authors.initials: G
authors.lastname: Sleilaty
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002303:Cardiac Output, Low / Q000097:blood*; D002405:Catheterization, Central Venous; D002407:Catheterization, Swan-Ganz; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors; D014683:Vena Cava, Superior / Q000502:physiology*
chemical_list: D010100:Oxygen