Borderline personality features possibly related to cingulate and orbitofrontal cortices dysfunction due to schizencephaly.
Prefrontal cortex dysfunction has been associated with a series of behavioral symptoms, such as impulsivity and affective instability, which are the defining features of several personality disorders, notably, borderline personality disorder. We report on a 27-year-old patient with schizencephaly in the right frontal lobe (cingulate cortex lesion and secondary orbitofrontal cortex dysfunction) presenting with prominent borderline features and compromise of executive functions, decision-making and attention. We hypothesize that the personality disorder of our patient could be related to cingulate cortex lesion and secondary orbitofrontal cortex dysfunction associated with schizencephaly.
da Rocha
Felipe Filardi
FF
Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Malloy-Diniz
Leandro
L
de Sousa
Karla Cristhina Alves
KC
Prais
Hugo Alejandro Cano
HA
Correa
Humberto
H
Teixeira
Antonio Lucio
AL
D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005625:Frontal Lobe / Q000002:abnormalities* / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000002:abnormalities* / Q000503:physiopathology; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000175:diagnosis; D009483:Neuropsychological Tests