title: Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma.
abstract: Because interaction existed between PTEN and RET-RAS-RAF-MAPK pathway, H4-PTEN (a newly identified gene rearrangement), RET/PTC and BRAF mutation were scanned in 125 Chinese patients with papillary thyroid carcinoma (PTC). H4-PTEN were detected in 9.6% of PTC and the frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%). On the other hand, age has an important effect on the aberration formation and young age renders more prone to multi-genetic events. A combinational scanning of these involved changes will improve the predictive value of molecular aberrations in the treatment of PTC.
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, 270 Dong'an Road, Shanghai 200032, China.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Wang
authors.forename: Jiu-Cun
authors.initials: JC
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shen
authors.forename: Yong-Xue
authors.initials: YX
authors.lastname: Zhu
authors.forename: Duan-Shu
authors.initials: DS
authors.lastname: Li
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Ji
mesh_terms: D000293:Adolescent; D000328:Adult; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: C088832:CCDC6 protein, human; D003598:Cytoskeletal Proteins; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human