title: Murine models for HIV vaccination and challenge.
abstract: HIV-1 only infects humans and chimpanzees. SIV or SHIV are, therefore, used as models for HIV in rhesus, cynomologus and pigtail macaques. Since conducting experiments in primate models does not fully mimic infection or vaccination against HIV-1 and is expensive, there is a great need for small-animal models in which it is possible to study HIV-1 infection, immunity and vaccine efficacy. This review summarizes the available murine models for studying HIV-1 infection with an emphasis on our experience of the HIV-1-infected-cell challenge as a model for evaluating candidate HIV-1 vaccines. In the cell-based challenge model, several important factors that, hopefully, can be related to vaccine efficacy in humans were discovered: the efficiency of combining plasmid DNA representing several of the viral genes originating from multiple clades of HIV-1, the importance of adjuvants activating innate and induced immunity and the enhanced HIV eradication by drug-conjugated antibody.
authors.affiliation: Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. andreas.boberg@smi.ki.se
authors.forename: Andreas
authors.initials: A
authors.lastname: Boberg
authors.forename: Andreas
authors.initials: A
authors.lastname: Bråve
authors.forename: Susanne
authors.initials: S
authors.lastname: Johansson
authors.forename: Britta
authors.initials: B
authors.lastname: Wahren
authors.forename: Jorma
authors.initials: J
authors.lastname: Hinkula
authors.forename: Erik
authors.initials: E
authors.lastname: Rollman
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D002460:Cell Line; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D023421:Models, Animal; D019076:Transgenes
chemical_list: D016915:AIDS Vaccines