Parent-child interactions, peripheral serotonin, and self-inflicted injury in adolescents.
Self-inflicted injury in adolescence indicates significant emotional and psychological suffering. Although data on the etiology of self-injury are limited, current theories suggest that the emotional lability observed among self-injuring adolescents results from complex interactions between individual biological vulnerabilities and environmental risk. For example, deficiencies in serotonergic functioning, in conjunction with certain family interaction patterns, may contribute to the development of emotional lability and risk for self-injury. The authors explored the relation between peripheral serotonin levels and mother-child interaction patterns among typical (n = 21) and self-injuring (n = 20) adolescents. Findings revealed higher levels of negative affect and lower levels of both positive affect and cohesiveness among families of self-injuring participants. Peripheral serotonin was also correlated with the expression of positive affect within dyads. Furthermore, adolescents' serotonin levels interacted with negativity and conflict within dyads to explain 64% of the variance in self-injury. These findings underscore the importance of considering both biological and environmental risk factors in understanding and treating self-injuring adolescents.
Crowell
Sheila E
SE
Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA. crowell@u.washington.edu
Beauchaine
Theodore P
TP
McCauley
Elizabeth
E
Smith
Cindy J
CJ
Vasilev
Christina A
CA
Stevens
Adrianne L
AL
D000223:Adaptation, Psychological / Q000502:physiology; D000293:Adolescent; D000339:Affect / Q000502:physiology; D003220:Conflict, Psychological; D005195:Family Relations; D005260:Female; D006801:Humans; D008297:Male; D009034:Mother-Child Relations; D010555:Personality Inventory; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000097:blood* / Q000523:psychology; D012701:Serotonin / Q000097:blood*; D012931:Social Environment; D013406:Suicide, Attempted / Q000523:psychology
D012701:Serotonin