RyR channels and glucose-regulated pancreatic beta-cells.
Ryanodine receptor channel model is introduced to a dynamical model of pancreatic beta-cells to discuss the effects of RyR channels and glucose concentration on membrane potential. The results show Ca2+ concentration changes responding to enhance of glucose concentration is more quickly than that of activating RyR channels, and both methods can induce bursting action potential and increase free cytosolic Ca2+ concentration. An interesting finding is that moderate stimulation to RyR channels will result in a kind of "complex bursting", which is more effective in enhancing average Ca2+ concentration and insulin section.
Zhan
Xuan
X
Department of Physics and Institute of Biophysics, Central China Normal University, 430079, Wuhan, China. zhanx@phy.ccnu.edu.cn
Yang
Lijian
L
Yi
Ming
M
Jia
Ya
Y
D002118:Calcium / Q000378:metabolism*; D003198:Computer Simulation; D005947:Glucose / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D015640:Ion Channel Gating / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology*; D008954:Models, Biological; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*
D019837:Ryanodine Receptor Calcium Release Channel; D005947:Glucose; D002118:Calcium