title: Activity of doripenem and comparator beta-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davies
authors.forename: Wenchi
authors.initials: W
authors.lastname: Shang
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
mesh_terms: D019881:Aminoacyltransferases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D006801:Humans; D009154:Mutation / Q000187:drug effects / Q000235:genetics*; D046915:Penicillin-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects / Q000235:genetics; D017434:Protein Structure, Tertiary; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D047090:beta-Lactams; C072223:PBP 2x protein, Streptococcus; D000077726:Doripenem; D019881:Aminoacyltransferases; C478701:penicillin-binding protein 2b, Streptococcus; C480727:PBP1a protein, Streptococcus pneumoniae; D010458:Peptidyl Transferases