title: Catalytic inactivation of human carbonic anhydrase I by a metallopeptide-sulfonamide conjugate is mediated by oxidation of active site residues.
authors.affiliation: Evans Laboratory of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Gokhale
authors.forename: Seth
authors.initials: S
authors.lastname: Bradford
authors.forename: J A
authors.initials: JA
authors.lastname: Cowan
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D015032:Zinc / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D010455:Peptides; D013449:Sulfonamides; D003300:Copper; D024401:Carbonic Anhydrase I; D015032:Zinc