Comprehensive two-dimensional liquid chromatography coupled with mass spectrometry.
In this review, instrumental aspects of comprehensive two-dimensional liquid chromatography coupled with mass spectrometry are presented. The milestones of LCxLC are briefly summarized. Instrument configuration, selection of experimental conditions, the different interfaces used in the system and the current applications of LCxLC-MS systems are described.
Pól
Jaroslav
J
Department of Chemistry, Laboratory of Analytical Chemistry, University of Helsinki, P.O. Box 55, 00014, Helsinki, Finland.
Hyötyläinen
Tuulia
T
D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D009930:Organic Chemicals / Q000032:analysis; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
D009930:Organic Chemicals; D012997:Solvents