Early death in children with acute lymphoblastic leukemia: does malnutrition play a role?
The study aim was to correlate malnutrition and early death in children with acute lymphoblastic leukemia (ALL). A study was conducted in 100 consecutive children with ALL. An analysis included clinical and laboratory parameters as well as co-morbidity factors. Forty patients were standard risk and 60 high risk. Multivariate analysis showed variables of statistical importance, including female gender (p 010), ALL high-risk (p 04), and infection (p 036). Malnutrition (p 1.0) and poverty (p 0.5) did not influence. Early mortality was documented in 15/100 (15%) patients. The study shows that high-risk ALL and infection represent the leading causes of early mortality.
Rivera-Luna
Roberto
R
Division of Hem-Oncology, National Institute of Pediatrics (Instituto Nacional de Pediatría), Mexico City, Mexico. riveraluna@infosel.net.mx
Olaya-Vargas
Alberto
A
Velásquez-Aviña
Martha
M
Frenk
Silvestre
S
Cárdenas-Cardós
Rocío
R
Leal-Leal
Carlos
C
Pérez-González
Oscar
O
Martínez-Avalos
Armando
A
D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections; D008297:Male; D044342:Malnutrition / Q000401:mortality*; D009026:Mortality; D011203:Poverty; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000401:mortality*; D012307:Risk Factors; D012737:Sex Factors