Proton beam therapy for hepatocellular carcinoma adjacent to the porta hepatis.
OBJECTIVE
To evaluate the efficacy and safety of proton beam therapy (PBT) for patients with hepatocellular carcinoma (HCC) located adjacent to the porta hepatis.


METHODS
Subjects of the study were 53 patients with HCC located within 2 cm of the main portal vein. All patients had tumor confined to the radiation field with no evidence of metastatic disease. All patients had hepatic function levels of a Child-Pugh score of 10 or less, Eastern Cooperative Oncology Group performance status of 2 or less, and no uncontrolled ascites. Patients underwent PBT of 72.6 GyE in 22 fractions from Sept 2001 to Dec 2004.


RESULTS
After 3 years, the actuarial survival rate was 45.1% and local control rate was 86.0%. Prognostic factors for survival included Child-Pugh score, number of tumors, and alpha-fetoprotein levels. No late treatment-related toxicity of Grade 2 or higher was observed.


CONCLUSIONS
The PBT delivering 72.6 GyE in 22 fractions appears to be effective and safe for HCC adjacent to the porta hepatis.
Mizumoto
Masashi
M
Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tokuuye
Koichi
K
Sugahara
Shinji
S
Nakayama
Hidetsugu
H
Fukumitsu
Nobuyoshi
N
Ohara
Kiyoshi
K
Abei
Masato
M
Shoda
Junichi
J
Tohno
Eriko
E
Minami
Manabu
M
D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000098:blood supply / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000098:blood supply / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D061766:Proton Therapy; D011879:Radiotherapy Dosage; D015996:Survival Rate; D000509:alpha-Fetoproteins / Q000378:metabolism
D000509:alpha-Fetoproteins