A synthesis of RGD model cyclic peptide by palladium-catalyzed carbonylative macrolactamization.
Cyclic peptidic RGD models were efficiently synthesized by Pd(P(t-Bu)3)2-catalyzed carbonylative macrolactamization in the presence of 4 A molecular sieves under 10 atm of carbon monoxide.
Doi
Takayuki
T
Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.
Kamioka
Seiji
S
Shimazu
Sayaka
S
Takahashi
Takashi
T
D002248:Carbon Monoxide; D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D010456:Peptides, Cyclic; C507169:cyclic arginine-glycine-aspartic acid peptide; D010165:Palladium; D002248:Carbon Monoxide