title: Failure of first SSRI for depression--what is the next step?
abstract: Failure in treating major depression with SSRI is common in clinical psychiatry. To date, there is no specific guideline how to deal with such a failure. This review is aimed at trying to answer the important question of the next step. Since there are no such guidelines, this decision should be made according to the clinical response for the first SSRI, the tolerability to the drug and the clinical practice of the physician.
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel. hagaima@clalit.org.il
authors.forename: Hagai
authors.initials: H
authors.lastname: Maoz
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004357:Drug Synergism; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors