title: Aggravated dry eye after laser in situ keratomileusis in patients with Sjögren syndrome.
abstract: OBJECTIVE
  To report 2 patients with Sjögren syndrome (SS) who had no or mild dry eye symptoms preoperatively but developed severe and refractory dry eye after laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Two women with well-controlled early-stage SS developed severe dry eye, punctate epithelial keratopathy, and refractive regression 15 and 2 months after LASIK. Both patients were treated with punctal occlusions, artificial tears, fluorometholone 0.02% eyedrops, autologous serum, and systemic immunosuppressants.
  
  
  RESULTS
  Ten months after treatment, both patients exhibited only minor improvements in dry eye symptoms on the basis of changes in Schirmer test results, corneal fluorescein staining, and refractive errors, whereas their tear breakup time and corneal sensation remained unchanged.
  
  
  CONCLUSIONS
  Severe and refractory dry eye can develop after LASIK in patients with preexisting well-controlled early-stage SS.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Lingyi
authors.initials: L
authors.lastname: Liang
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Wenjin
authors.initials: W
authors.lastname: Zou
authors.forename: Zuguo
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D015352:Dry Eye Syndromes / Q000209:etiology* / Q000628:therapy; D005260:Female; D005469:Fluorometholone / Q000627:therapeutic use; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D007765:Lacrimal Apparatus / Q000601:surgery; D009216:Myopia / Q000150:complications* / Q000601:surgery; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D044967:Serum; D012859:Sjogren's Syndrome / Q000150:complications*; D013666:Tears / Q000378:metabolism
chemical_list: D009883:Ophthalmic Solutions; D005469:Fluorometholone