Role of serotonin in the regulation of granulocytopoiesis during cytostatic-induced myelosuppressions.
We studied the role of the serotoninergic system in the regulation of the granulocytic hemopoietic stem during cytostatic myelosuppressions caused by administration of cyclophosphamide or 5-fluorouracil. After cytostatic treatment, the state of granulocytopoietic precursors and functional activity of cells in the hemopoiesis-inducing microenvironment were regulated by serotoninergic structures of the brain. The regulatory influence of CNS was realized via serotonin receptors on precursors and microenvironment cells. The response of the granulocytic stem was determined by specific interaction between distant and local regulatory structures and inhibitory effect of cyclophosphamide and 5-fluorouracil on granulocytic cells and regulatory systems.
Skurikhin
E G
EG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Pershina
O V
OV
Minakova
M Yu
MY
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D002455:Cell Division / Q000502:physiology*; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D006098:Granulocytes / Q000166:cytology*; D051379:Mice; D008808:Mice, Inbred CBA; D012701:Serotonin / Q000502:physiology*
D000970:Antineoplastic Agents; D012701:Serotonin; D003520:Cyclophosphamide; D005472:Fluorouracil