[Tumor-stroma interactions].
It is widely accepted that the development of carcinoma is not only due to somatic mutations in epithelial cells but also is influenced by the tumor microenvironment ie the stroma. The different stroma components produced growth factors, cytokines, the extra cellular matrix and also participated to the recruitment of the endothelial cells necessary for the tumor neovascularisation. The stroma favored the oncogenesis through synergistic reciprocal paracrine signals with the tumor cells. The stroma is determinant for the tumor progression and therefore is an important therapeutic target.
Billottet
Clotilde
C
U889 Inserm, Biologie cellulaire et moléculaire, 2, rue Robert-Escarpit, 33607 Pessac Cedex, France. c.billottet@iecb.u-bordeaux.fr
Jouanneau
Jacqueline
J
D002277:Carcinoma / Q000473:pathology* / Q000503:physiopathology; D002450:Cell Communication; D002462:Cell Membrane / Q000502:physiology; D018450:Disease Progression; D016228:Endothelial Growth Factors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000209:etiology; D017154:Stromal Cells / Q000473:pathology* / Q000502:physiology; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
D016228:Endothelial Growth Factors; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D042442:Vascular Endothelial Growth Factors; D020782:Matrix Metalloproteinases