Effectiveness of sputum cytology using ThinPrep method for evaluation of lung cancer.
Sputum cytology is a non-invasive test for evaluating lung cancer. But, its sensitivity is yet lower than other tests. ThinPrep (TP) is an automated cytopreparatory method that has mucolytic and hemolysing effects. We compared 955 sputum specimens that were prepared by both TP and conventional preparation (CP). The nuclear details were more preserved on the TP slides, while the obscuring materials were more eliminated on the TP slides as compared with the CP. The cytologic rates of TP were 2.7% unsatisfactory, 4.7% normal, 81.0% benign, 2.4% suspicious, and 9.1% malignancy. The rates of CP were 7.9% unsatisfactory, 1.6% normal, 84.8% benign, 1.8% suspicious, and 4.0% malignancy. The false negative rates, relative to the histologic data for 352 cases which the tissue diagnosis was available, were 49.6% (TP) and 69.4% (CP). Sputum cytology using the TP method improves the diagnostic accuracy for evaluating lung cancer by reducing the unsatisfactory and false-negative rates.
Choi
Yoo-Duk
YD
Department of Pathology, Chonnam National University Medical School, Gwang-Ju, Republic of Korea.
Han
Chang-Woo
CW
Kim
Jo-Heon
JH
Oh
In-Jae
IJ
Lee
Ji-Shin
JS
Nam
Jong-Hee
JH
Juhng
Sang-Woo
SW
Park
Chang-Soo
CS
D000230:Adenocarcinoma / Q000175:diagnosis; D002277:Carcinoma / Q000175:diagnosis*; D018287:Carcinoma, Large Cell / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003581:Cytodiagnosis / Q000379:methods; D016591:Histocytological Preparation Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013183:Sputum / Q000166:cytology*