title: Dimerization of G protein-coupled receptors: new avenues for somatostatin receptor signalling, control and functioning.
abstract: Somatostatin acts through binding and activation of five G protein-coupled receptors (GPCRs) termed somatostatin receptors or ssts (sst1-sst5). These receptors, as many other GPCRs are not just monomers but display a differential tendency to homodimerize, which varies depending on the sst subtype. Moreover, there is evidence that pairs of distinct receptors such as ssst2-sst3 and sst1-sst5 crosstalk by establishing a physical interaction, which results in altered pharmacological or/and functional properties. In addition, ssts can also heterodimerize with other families of GPCRs, as opioid and dopamine receptors, originating heterodimers which properties are different to those of their separated receptors. The present review summarizes the current knowledge on ssts homodimerization, heterodimerization, and interaction with other GPCRs, as well as how interactions affect different aspects of the normal functioning of these receptors.
authors.affiliation: Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Durán-Prado
authors.forename: María M
authors.initials: MM
authors.lastname: Malagón
authors.forename: F
authors.initials: F
authors.lastname: Gracia-Navarro
authors.forename: Justo P
authors.initials: JP
authors.lastname: Castaño
mesh_terms: D000818:Animals; D006801:Humans; D055503:Protein Multimerization; D020239:Receptor Cross-Talk; D011954:Receptors, Dopamine / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D011957:Receptors, Opioid / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011954:Receptors, Dopamine; D043562:Receptors, G-Protein-Coupled; D011957:Receptors, Opioid; D017481:Receptors, Somatostatin