Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura.
In previous studies, we described subclinical abnormalities of neuromuscular transmission and cerebellar functions in migraineurs. The aim of this study was to search if these two functions are correlated in the same patient. Thirteen migraineurs [five without aura (MO) and eight with aura (MA)] underwent both stimulation-SFEMG and 3D-movement analysis. Single fiber EMG (SFEMG) results were expressed as the "mean value of consecutive differences" (mean MCD). Precision of arm-reaching movements (measured with an infrared optoelectronic tracking system) was expressed as the average deviation in the horizontal plane. Median values of mean MCD and mean horizontal deviation were not different between MO and MA. However, in MA, but not in MO, both variables were positively correlated. Thus, we conclude that neuromuscular transmission and cerebellar functions are correlated in the same patient when affected by migraine with aura. We suggest that this correlation might be due to a common molecular abnormality.
Ambrosini
Anna
A
Headache Clinic, IRCCS INM Neuromed, via Atinense 18, 86077 Pozzilli, Isernia, Italy. anna.ambrosini@neuromed.it
Sándor
Peter S
PS
De Pasqua
Victor
V
Pierelli
Francesco
F
Schoenen
Jean
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena; D002526:Cerebellar Diseases / Q000235:genetics / Q000503:physiopathology*; D002531:Cerebellum / Q000378:metabolism / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics / Q000503:physiopathology*; D009069:Movement Disorders / Q000235:genetics / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009468:Neuromuscular Diseases / Q000235:genetics / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000378:metabolism / Q000503:physiopathology; D009435:Synaptic Transmission / Q000235:genetics
D009419:Nerve Tissue Proteins