Fibrinogen gamma' in ischemic stroke: a case-control study.
OBJECTIVE
To determine the contribution of fibrinogen gamma' levels and FGG haplotypes to ischemic stroke.


METHODS
Associations between fibrinogen gamma' levels, fibrinogen gamma'/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls.


RESULTS
Fibrinogen gamma'/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen gamma'/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen gamma'/total fibrinogen ratio, but not with risk of stroke.


CONCLUSIONS
Fibrinogen gamma'/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.
Cheung
Elim Y L
EY
Uitte de Willige
Shirley
S
Vos
Hans L
HL
Leebeek
Frank W G
FW
Dippel
Diederik W J
DW
Bertina
Rogier M
RM
de Maat
Moniek P M
MP
D000328:Adult; D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D014644:Genetic Variation; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000097:blood* / Q000209:etiology* / Q000517:prevention & control
D015241:Fibrinogens, Abnormal; C527521:fibrinogen gamma'