title: HLA-G: from biology to clinical benefits.
abstract: The relevance of the nonclassical human leukocyte antigen (HLA) class I molecule HLA-G in human physiological and pathological contexts has been the center of intense investigation. In light of the recent advances, we report here the clinical implications of HLA-G as a tolerogenic molecule promoting uterine implantation of the embryo or acceptance of solid allografts while allowing the evasion of tumors or viruses from the immune response. These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels.
authors.affiliation: Institut Universitaire d'Hématologie, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, IUH, 1 75010 Paris, France.
authors.forename: Edgardo D
authors.initials: ED
authors.lastname: Carosella
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Joël
authors.initials: J
authors.lastname: Lemaoult
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rouas-Freiss
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000276:immunology; D006680:HLA Antigens / Q000502:physiology* / Q000627:therapeutic use*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D023001:Transplantation Tolerance / Q000276:immunology; D019139:Tumor Escape / Q000276:immunology
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I