1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma.
Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
Hibi
Masahito
M
Department of Pediatric Surgery, Fujita Health University, Toyoake, Aichi, Japan. mhibi@fujita-hu.ac.jp
Masahito
Hibi
H
Hara
Fujio
F
Tomishige
Hirokazu
H
Nishida
Yoshihisa
Y
Kato
Takazumi
T
Okumura
Naotake
N
Hashimoto
Takashi
T
Kato
Ryoichi
R
D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002648:Child; D004407:Dysgerminoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery
D002117:Calcitriol; D002118:Calcium