title: [Effects of centipede extract on life span of drosophila].
abstract: OBJECTIVE
  To evaluate effects of centipede on life span of drosophila and on the appearance of the filial generation.
  
  
  METHODS
  Drosophila melanogaster (male and female) were cultured in tubes with centipede extraction at concentrations of 0, 0.2%, 1%, 2.5%, or 5% until all drosophila died. The appearance of the filial generation were observed.
  
  
  RESULTS
  The life span, including average, longest and shortest life span was shortened in exposed groups of both sexes and significantly dose-dependent. The appearance of the filial generation showed normal.
  
  
  CONCLUSIONS
  Centipede extracts accelerates the aging of drosophila and shortens their life span. The appearance of the filial generation is not affected. Clinic using centipede for a long period should be carefully.
authors.affiliation: School of Chinese Material Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Cui
authors.forename: Chao-ran
authors.initials: CR
authors.lastname: Wang
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Yu-long
authors.initials: YL
authors.lastname: Duan
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Wang
mesh_terms: D000818:Animals; D001181:Arthropods / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology; D008136:Longevity / Q000187:drug effects*; D008419:Materia Medica / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D008419:Materia Medica