Three new polyketide-terpenoid hybrids from Penicillium sp.
Three novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium minioluteum strain. Their structures were determined by NMR spectroscopic analyses and X-ray crystallography. The proposed biosynthetic pathway including a unique retro-Claisen migration of methyl carbonate correlates the three compounds with berkeleydione and berkeleytrione.
Iida
Motoo
M
Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.
Ooi
Takashi
T
Kito
Keijiro
K
Yoshida
Sanae
S
Kanoh
Kaneo
K
Shizuri
Yoshikazu
Y
Kusumi
Takenori
T
D018360:Crystallography, X-Ray; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
C528590:22-epoxyberkeleydione; D018942:Macrolides; D013729:Terpenes; C493366:berkeleydione; C493367:berkeleytrione; C528591:miniolutelide A; C528592:miniolutelide B