Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C.
OBJECTIVE
For addressing the influence of muscle mass on serum and urinary creatinine and serum cystatin C, body composition was assessed by skinfold thickness measurement and bioelectrical impedance analyses.


METHODS
A total of 170 healthy individuals (92 women, 78 men) were classified as sedentary or with mild or moderate/intense physical activity. Blood, 24-h urine samples, and 24-h food recall were obtained from all individuals.


RESULTS
Serum and urinary creatinine correlated significantly with body weight, but the level of correlation with lean mass was even greater. There was no significant correlation between body weight and lean mass with cystatin C. Individuals with moderate/intense physical activity presented significantly lower mean body mass index (23.1 +/- 2.5 versus 25.7 +/- 3.9 kg/m(2)) and higher lean mass (55.3 +/- 10.0 versus 48.5 +/- 10.4%), serum creatinine (1.04 +/- 0.12 versus 0.95 +/- 0.17 mg/dl), urinary creatinine (1437 +/- 471 versus 1231 +/- 430 mg/24 h), protein intake (1.4 +/- 0.6 versus 1.1 +/- 0.6 g/kg per d), and meat intake (0.7 +/- 0.3 versus 0.5 +/- 0.4 g/kg per d) than the sedentary individuals. Conversely, mean serum cystatin did not differ between these two groups. A multivariate analysis of covariance showed that lean mass was significantly related to serum and urinary creatinine but not with cystatin, even after adjustment for protein/meat intake and physical activity.


CONCLUSIONS
Cystatin C may represent a more adequate alternative to assess renal function in individuals with higher muscle mass when mild kidney impairment is suspected.
Baxmann
Alessandra Calábria
AC
Universidade Federal de São Paulo, Nephrology Division, Rua Botucatu 740, Vila Clementino, São Paulo, SP 04023-900, Brazil.
Ahmed
Marion Souza
MS
Marques
Natália Cristina
NC
Menon
Viviane Barcellos
VB
Pereira
Aparecido Bernardo
AB
Kirsztajn
Gianna Mastroianni
GM
Heilberg
Ita Pfeferman
IP
D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood* / Q000652:urine*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D018482:Muscle, Skeletal; D012885:Skinfold Thickness
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine