Anticancer constituents from the roots of Rubia cordifolia L.
Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.
Son
Jong Keun
JK
College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
Jung
Soon Ja
SJ
Jung
Ji Hyun
JH
Fang
Zhe
Z
Lee
Chong Soon
CS
Seo
Chang Seob
CS
Moon
Dong Cheul
DC
Min
Byung Sun
BS
Kim
Mi Ryeo
MR
Woo
Mi Hee
MH
D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology*; D045470:Rubia / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D009284:Naphthols; D011714:Pyrans; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C527316:epoxymollugin