title: Chiral N-phosphonyl imine chemistry: asymmetric aza-Henry reaction.
abstract: A series of chiral N-phosphonyl imines have been synthesized and utilized successfully in asymmetric aza-Henry reaction. The chiral auxiliary was optimized for this reaction by varying different R groups on the nitrogen atoms. The reaction is convenient to perform to give excellent yields and good diastereoselectivities. The absolute stereochemistry was unambiguously determined by converting a resulting vicinal nitroamine into its N-Boc derivative which serves as a known compound.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA.
authors.forename: Adiseshu
authors.initials: A
authors.lastname: Kattuboina
authors.forename: Parminder
authors.initials: P
authors.lastname: Kaur
authors.forename: Teng
authors.initials: T
authors.lastname: Ai
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D007097:Imines