IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden.
There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6 -174 G>C (Minor allele frequency (MAF) = 48%) gene promoter polymorphism was associated with the primary outcome total fat mass (P = 0.006) and regional fat masses, but not with lean body mass. The IL1B -31T>C (MAF = 34%) polymorphism was also associated with total fat (P = 0.007) and regional fat masses, but not lean body mass. The IL-1 receptor antagonist (IL-1ra) gene (IL1RN) +2018 T>C (MAF = 27%) polymorphism (in linkage disequilibrium (LD) with a well-studied variable number tandem repeat of 86 base pair (bp)) and IL1B +3953 C>T (MAF = 26%) polymorphism were not associated with total fat mass. In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men.
Strandberg
Louise
L
Institute of Neuroscience and Physiology/Endocrinology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Mellström
Dan
D
Ljunggren
Osten
O
Grundberg
Elin
E
Karlsson
Magnus K
MK
Holmberg
Anna H
AH
Orwoll
Eric S
ES
Eriksson
Anna L
AL
Svedberg
Johan
J
Bengtsson
Magnus
M
Ohlsson
Claes
C
Jansson
John-Olov
JO
D015502:Absorptiometry, Photon; D050154:Adiposity / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D020029:Base Pairing; D015992:Body Mass Index; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D018598:Minisatellite Repeats; D008957:Models, Genetic; D010446:Peptide Fragments / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D013548:Sweden; D013851:Thinness / Q000235:genetics*
C507763:IL1RN protein, human; C508600:IL6 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D015850:Interleukin-6; D010446:Peptide Fragments; C052994:interleukin-1beta (163-171)