title: Comprehensive two-dimensional liquid chromatography coupled with mass spectrometry.
abstract: In this review, instrumental aspects of comprehensive two-dimensional liquid chromatography coupled with mass spectrometry are presented. The milestones of LCxLC are briefly summarized. Instrument configuration, selection of experimental conditions, the different interfaces used in the system and the current applications of LCxLC-MS systems are described.
authors.affiliation: Department of Chemistry, Laboratory of Analytical Chemistry, University of Helsinki, P.O. Box 55, 00014, Helsinki, Finland.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Pól
authors.forename: Tuulia
authors.initials: T
authors.lastname: Hyötyläinen
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D009930:Organic Chemicals / Q000032:analysis; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
chemical_list: D009930:Organic Chemicals; D012997:Solvents