title: Allogeneic hematopoietic stem cell transplantation using a reduced-intensity conditioning regimen in infants: experience at a single institution in Mexico.
abstract: The authors report their experience with allogeneic hematopoietic stem cell transplantation in infants at a university hospital in México. Five infants had one of each of the following diagnoses: acute lymphoblastic leukemia, osteopetrosis for which the patient underwent 2 procedures, acute disseminated multiorgan Langerhans cell histiocytosis, and two cases of hemophagocytic lymphohistiocytosis. The source of stem cells for grafting in 2 children was peripheral blood, and in 3 children was unrelated cord blood. A reduced-intensity conditioning regimen including fludarabine, cyclophosphamide, and melphalan was administrated. Three patients are disease-free transplant survivors without graft-versus-host disease after 46, 34, and 16 months.
authors.affiliation: Pediatric Department and Hematology Service, School of Medicine and University Hospital, "Dr. Jose E. Gonzalez," Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. ogzzll25@hotmail.com
authors.forename: Oscar Gonzalez
authors.initials: OG
authors.lastname: Llano
authors.forename: José Carlos Jaime
authors.initials: JC
authors.lastname: Perez
authors.forename: Olga Cantu
authors.initials: OC
authors.lastname: Rodriguez
authors.forename: Consuelo Mancias
authors.initials: CM
authors.lastname: Guerra
authors.forename: Homero Gutiérrez
authors.initials: HG
authors.lastname: Aguirre
authors.forename: Jose Luis Herrera
authors.initials: JL
authors.lastname: Garza
authors.forename: Laura
authors.initials: L
authors.lastname: Rodriguez-Romo
authors.forename: David Gomez
authors.initials: DG
authors.lastname: Almaguer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D006402:Hematologic Diseases / Q000150:complications / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008558:Melphalan / Q000008:administration & dosage; D008800:Mexico; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine; D008558:Melphalan