Autopsy cases of fulminant-type bacterial infection with necrotizing fasciitis: group A (beta) hemolytic Streptococcus pyogenes versus Vibrio vulnificus infection.
Two autopsy cases of fulminant-type infection associated with necrotizing fasciitis were analyzed clinicopathologically. Both cases involved 57-year-old alcohol abusers. The former was a woman with group A (beta) hemolytic Streptococcus pyogenes infection, and the latter was a man with Vibrio vulnificus infection. The sudden onset of shock with high fever resulted in sepsis, decreased clotting, and hepatorenal symptoms, followed by death within a few days. Post-mortem examination showed widespread congestion and bleeding, and alcoholic liver cirrhosis was observed. Necrotizing fasciitis was identified in both cases. Bacteria from the pharynx or intestinal tract invaded the blood, and marked bacterial proliferation produced sepsis, resulting in necrotizing fasciitis. Despite the presence of sepsis, bilateral pulmonary congestion and bleeding were observed without pneumonia. Due to the rapid progression of sepsis, there was no time for granulocyte migration from the bone marrow. It seems that almost all mature granulocytes which had already existed in the bone marrow accumulated at the focus of necrotizing fasciitis because the bone marrow had few mature granulocytes and lacked hypercellularity. The cause of death in each case was circulatory collapse due to septic shock. It was difficult to distinguish the type of infection on histopathology. Cultures were necessary to determine the bacterial agents involved.
Tajiri
Takuma
T
Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan. takumatajiri1003@yahoo.co.jp
Tate
Genshu
G
Akita
Hidetaka
H
Ohike
Nobuyuki
N
Masunaga
Atsuko
A
Kunimura
Toshiaki
T
Mitsuya
Toshiyuki
T
Morohoshi
Toshio
T
D001431:Bacteriological Techniques; D019115:Fasciitis, Necrotizing / Q000382:microbiology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000382:microbiology / Q000473:pathology*; D013290:Streptococcal Infections / Q000473:pathology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification*; D014735:Vibrio Infections / Q000150:complications / Q000473:pathology*; D041261:Vibrio vulnificus / Q000302:isolation & purification*