title: [Gene expression profile of the peripheral CD4(+)T cells in patients with RF(+) and RF(-) rheumatoid arthritis].
abstract: OBJECTIVE
  To explore the differences of the gene expression of CD4(+) lymphocytes between the RF(+) and RF(-) patients with rheumatoid arthritis.
  
  
  METHODS
  mRNA of all the CD4(+) lymphocytes samples were extracted and identified. Then they were labeled and hybridized to microarrays.
  
  
  RESULTS
  Hierarchical clustering analysis showed there were 55 differential expression genes between the RF(+) and RF(-) patients with rheumatoid arthritis.
  
  
  CONCLUSIONS
  There are differential expression genes between the RF(+) and RF(-) patients and these genes are related to immunoresponse.
authors.affiliation: Institute of Basic Research in Chinical Medicine, Beijing 100700, China. lv_cheng0816@163.com
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Xu
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiao
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Yan
authors.forename: Lin-hua
authors.initials: LH
authors.lastname: Zhao
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Wang
authors.forename: Shao
authors.initials: S
authors.lastname: Li
authors.forename: Ai-ping
authors.initials: AP
authors.lastname: Lu
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D012217:Rheumatoid Factor / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D012217:Rheumatoid Factor