title: Cerebral blood volume changes in patients with eating disorders during word fluency: a preliminary study using multi-channel near infrared spectroscopy.
abstract: OBJECTIVE
  This study investigated the characteristics of cerebral oxygenation changes in eating disorders patients (ED) and normal controls during the cognitive tasks, using a highly time-resolved, and non-invasive instrument.
  
  
  METHODS
  Eleven female patients with anorexia nervosa or bulimia nervosa were recruited, and 11 healthy females participated. The relative concentrations of oxy-hemoglobin [o-Hb] and deoxy-hemoglobin [d-Hb] were measured during word fluency task using multichannel near infrared spectroscopy (NIRS).
  
  
  RESULTS
  The increases of o-Hb and d-Hb during the task were compared between the groups. ED patients showed lower activation and a gradual increase in o-HB during the task. In the frontal, d-HB concentrations decreased during the task in ED patients.
  
  
  CONCLUSIONS
  These specific patterns of oxygenation changes may indicate less supply and less demand of cerebral blood volume. Bedside measurements of cerebral oxygenation changes using NIRS are useful on understanding of neurophysiological features of ED.
authors.affiliation: Department of Psychiatry and Human Behavior, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan. toruaki@med.gunma-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: M
authors.initials: M
authors.lastname: Suda
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Suto
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: M
authors.initials: M
authors.lastname: Mikuni
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D052018:Bulimia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D009483:Neuropsychological Tests; D010101:Oxygen Consumption / Q000502:physiology; D010108:Oxyhemoglobins / Q000378:metabolism; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D019265:Spectroscopy, Near-Infrared; D014705:Verbal Behavior / Q000502:physiology*
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin