Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach.
Experiments on smooth muscles of rat stomach showed that lysophosphatidylcholine in concentrations of 10(-8) and 10(-7) g/ml does not modulate the tonotropic effect of acetylcholine (10(-6) g/ml), in a concentration of 10(-6) g/ml potentiated this effect (similarly to phosphatidylcholine, 10(-6) g/ml), and reduced it in concentrations of 10(-5)-10(-4) g/ml (similarly to hen egg yolk in dilutions of 1:500, 1:100, and 1:500). These data indicate that lysophosphatidylcholine modifies signal transduction from the receptor to G protein.
Kunshin
A A
AA
Department of Normal Physiology, Kirov State Medical Academy, Moscow.
Tsyrkin
V I
VI
Prokazova
N V
NV
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004530:Egg Yolk; D005260:Female; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology; D013270:Stomach / Q000187:drug effects / Q000502:physiology
D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D011976:Receptors, Muscarinic; D000109:Acetylcholine