title: Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging.
abstract: Decline in cognitive functions that accompany aging in dogs may have a biologic basis, and many of the disorders associated with aging in dogs may be mitigated through dietary modifications that incorporate specific nutraceuticals. Based on previous research and the results of laboratory and clinical studies, antioxidants may be one class of nutraceutical that provides benefits to aged dogs. Brains of aged dogs accumulate oxidative damage to proteins and lipids, which may lead to dysfunction of neuronal cells. The production of free radicals and lack of increase in compensatory antioxidant enzymes may lead to detrimental modifications to important macromolecules within neurons. Reducing oxidative damage through food ingredients rich in a broad spectrum of antioxidants significantly improves, or slows the decline of, learning and memory in aged dogs.
authors.affiliation: Institute for Brain Aging and Dementia, Department of Neurology, University of California at Irvine, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Head
authors.forename: Jaime
authors.initials: J
authors.lastname: Rofina
authors.forename: Steven
authors.initials: S
authors.lastname: Zicker
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000502:physiology / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001927:Brain Diseases / Q000378:metabolism* / Q000517:prevention & control / Q000628:therapy; D003072:Cognition Disorders / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy; D004032:Diet; D004195:Disease Models, Animal; D004285:Dogs; D058870:Food, Organic; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D005609:Free Radicals