title: Prognostic irrelevance of HLA-G in B-cell chronic lymphocytic leukemia.
abstract: In the last few years, it has been suggested that the involvement of human leukocyte antigen-G (HLA-G) in several tumoral processes and its likely participation as a factor of immune tolerance in malignant cells. Recently, positive HLA-G surface expression has been associated with a poor prognosis in a small group of patients with B-cell chronic lymphocytic leukemia (B-CLL), a lymphoproliferative disorder characterized by a heterogeneous clinical course. In the present work, 169 patients suffering from B-CLL were analyzed for the expression of HLA-G by flow cytometry in order to verify its prognostic value in a larger cohort. We observed a low expression of this molecule on leukemic B cells and no significant relation to clinical data or progression-free survival time, indicating that this molecule is not as good immunologic prognostic marker for B-CLL as suggested.
authors.affiliation: Fundacion LAIR, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Perez-Chacon
authors.forename: S
authors.initials: S
authors.lastname: Rosado
authors.forename: N
authors.initials: N
authors.lastname: Rebolleda
authors.forename: I
authors.initials: I
authors.lastname: Losada-Fernandez
authors.forename: J A
authors.initials: JA
authors.lastname: Vargas
authors.forename: M
authors.initials: M
authors.lastname: Morado
authors.forename: J
authors.initials: J
authors.lastname: Jorda
authors.forename: P
authors.initials: P
authors.lastname: Perez-Aciego
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I