Involvement of the serotoninergic system in the mechanism of action of ultralow dose antibodies to S-100 protein.
The involvement of the serotoninergic system in the realization of anxiolytic and antidepressant activities of antibodies to S-100 protein in ultralow doses is proven. Administration of ultralow-dose antibodies to S-100 protein in combination with serotoninergic agents (ketanserin and 5-hydroxytryptophan) reduced the anxiolytic and antidepressant effects of antibodies.
Kheifets
I A
IA
Materia Medica Holding, Moscow, Russia. heifezia@materiamedica.ru
Dugina
Yu L
YL
Voronina
T A
TA
Molodavkin
G M
GM
Martyushev-Poklad
A V
AV
Sergeeva
S A
SA
Epstein
O I
OI
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051381:Rats; D009418:S100 Proteins / Q000276:immunology*; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D009418:S100 Proteins; D012702:Serotonin Antagonists; D012701:Serotonin; D007650:Ketanserin