title: In vitro phenotypic susceptibility of human immunodeficiency virus type 2 clinical isolates to protease inhibitors.
abstract: We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.
authors.affiliation: Laboratoire de Virologie, Service de Microbiologie, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Desbois
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Roquebert
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Gilles
authors.initials: G
authors.lastname: Collin
authors.forename: Antoine
authors.initials: A
authors.lastname: Bénard
authors.forename: Pauline
authors.initials: P
authors.lastname: Campa
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D000069454:Darunavir; D016333:HIV Protease / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015498:HIV-2 / Q000145:classification* / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D020128:Inhibitory Concentration 50; D061466:Lopinavir; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D011744:Pyrimidinones / Q000494:pharmacology; D019258:Saquinavir / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D013449:Sulfonamides; D061466:Lopinavir; D016333:HIV Protease; D019258:Saquinavir; D000069454:Darunavir