title: P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia.
abstract: OBJECTIVE
  P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gating deficit.
  
  
  METHODS
  P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects.
  
  
  RESULTS
  P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (chi(2) = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables.
  
  
  CONCLUSIONS
  Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.
authors.affiliation: Department of Psychiatry, Hospital General Universitario de Guadalajara, Guadalajara, Spain. emsanchez@sescam.jccm.es
authors.forename: E M
authors.initials: EM
authors.lastname: Sánchez-Morla
authors.forename: M A
authors.initials: MA
authors.lastname: García-Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Barabash
authors.forename: V
authors.initials: V
authors.lastname: Martínez-Vizcaíno
authors.forename: J
authors.initials: J
authors.lastname: Mena
authors.forename: J A
authors.initials: JA
authors.lastname: Cabranes-Díaz
authors.forename: E
authors.initials: E
authors.lastname: Baca-Baldomero
authors.forename: J L
authors.initials: JL
authors.lastname: Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D019263:Dysthymic Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*