title: Skin invasion and prognosis in node negative breast cancer: a retrospective study.
abstract: BACKGROUND
  The impact of skin invasion in node negative breast cancer is uncertain.
  
  
  METHODS
  We determined the prognosis in 97 node negative breast cancer patients (case group) who had tumors with skin invasion. Then we compared these patients with 4500 node negative invasive breast cancer patients treated surgically in the same period.
  
  
  RESULTS
  Patients with skin invasion tended to be older, had more invasive lobular carcinoma and larger tumor size, and were less likely to have breast conserving surgery than those in the control group. The 5-year disease-free survival rate in the case group was 94.0%. There was no significant difference in the 10-year disease-specific overall survival rates in terms of skin invasion in node negative patients (90.7% in the case group, 92.9% in the control group; p = 0.2032).
  
  
  CONCLUSIONS
  Results suggest that skin invasion has no impact on survival in node negative invasive breast cancer patients. The adjuvant regimens which the individual institute applies for node negative breast cancer should be used regardless of skin invasion.
authors.affiliation: Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan. ktada@jfcr.or.jp
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Tada
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Morizono
authors.forename: Kotaro
authors.initials: K
authors.lastname: Iijima
authors.forename: Yumi
authors.initials: Y
authors.lastname: Miyagi
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Nishimura
authors.forename: Masujiro
authors.initials: M
authors.lastname: Makita
authors.forename: Rie
authors.initials: R
authors.lastname: Horii
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.forename: Takuji
authors.initials: T
authors.lastname: Iwase
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000556:secondary* / Q000601:surgery; D016019:Survival Analysis