Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.
Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin-(3',5'-diol) ( 1) and psoroxanthin ( 4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line).
Leet
John E
JE
Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. leetj@bms.com
Liu
Xiaohong
X
Drexler
Dieter M
DM
Cantone
Joseph L
JL
Huang
Stella
S
Mamber
Stephen W
SW
Fairchild
Craig R
CR
Hussain
Raouf
R
Newman
David J
DJ
Kingston
David G I
DG
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002417:Cattle; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D008270:Madagascar; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones