title: Effect of subcutaneously administered diclazuril on the output of Eimeria species oocysts by experimentally infected rabbits.
abstract: The effect of subcutaneously injected diclazuril on the output of Eimeria species oocysts was studied in experimentally infected rabbits. Diclazuril was administered either prophylactically at 0.5, 1 or 2 mg/kg bodyweight two days before each rabbit was inoculated with 20,000 oocysts of a mixed-species field isolate of Eimeria or therapeutically at 1, 2 or 4 mg/kg bodyweight five days after they were inoculated. The prophylactic treatments significantly reduced (P<0.05) the output of oocysts in faeces and the numbers in the rabbits' livers at all doses. The therapeutic treatment at 4 mg/kg also caused a significant reduction (P<0.05) in oocyst shedding, but the lower doses resulted in only a moderate reduction. The shedding of the pathogenic species Eimeria stiedae, Eimeria magna, Eimeria irresidua, Eimeria flavescens, Eimeria piriformis and Eimeria intestinalis was significantly reduced (P<0.05) in all the treated groups. The burden of oocysts in the livers of the therapeutic groups (4000 to 9000) were significantly lower (P<0.05) than in the inoculated but untreated control group (23,000), but higher than in the prophylactic groups (around 1000).
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing 100094, China.
authors.forename: B L
authors.initials: BL
authors.lastname: Pan
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Suo
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology*; D004539:Eimeria; D005243:Feces / Q000469:parasitology; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D008099:Liver / Q000187:drug effects / Q000469:parasitology; D008297:Male; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology*; D033661:Oocysts; D011529:Protozoan Infections, Animal / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D011817:Rabbits; D012370:Robenidine / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014227:Triazines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; D012370:Robenidine; C057884:diclazuril