A very private TGF-beta receptor embrace.
In this issue of Molecular Cell, Groppe et al. (2008) describe the crystal structure of a six-element TGF-beta:receptor complex, addressing long-standing questions about the restrictive nature of this vital receptor interaction.
Massagué
Joan
J
Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. massaguj@mskcc.org
D052004:Bone Morphogenetic Protein Receptors / Q000737:chemistry / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D018360:Crystallography, X-Ray; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism; D020836:Protein Structure, Quaternary / Q000502:physiology; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051785:Smad Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D053782:Transforming Growth Factor beta3 / Q000737:chemistry* / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D046912:Multiprotein Complexes; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D053782:Transforming Growth Factor beta3; D052004:Bone Morphogenetic Protein Receptors