Structural insights shed light onto septin assemblies and function.
While the original septin mutants were identified more than 30 years ago for their role in cytokinesis [Hartwell, LH: Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 1971, 69: 265-276], the architecture of septin complexes and higher order structures has remained a mystery up until very recently. Over the last few months a number of converging approaches have suddenly provided a wealth of structural information about the different levels of septin organization. Here, we review these advancements and highlight their functional consequences.
Barral
Yves
Y
Institut für Biochemie, ETH Zürich, Schafmattstrasse 18, Zürich, Switzerland. yves.barral@bc.biol.ethz.ch
Kinoshita
Makoto
M
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism
D021122:Protein Subunits; D010744:Phosphoric Monoester Hydrolases