Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities.
In this study, di(2,6-dimethylphenol) (Di-DMP), di(2,6-diisopropylphenol) (Di-DIP, dipropofol) and di(2,6-di-t-butylphenol) (Di-DTP) were synthesized by the reaction of monomeric phenol derivatives with catalytic CuCl(OH). TMEDA and Na2S2O4. Their antioxidant capacity and radical scavenging activity were examined using different in vitro methodologies such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH*) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity by ferric thiocyanate, total reducing power by potassium ferricyanide reduction method, superoxide anion radical scavenging, hydrogen peroxide scavenging and ferrous ions chelating activities.
Güllçin
Ilhami
I
Atatürk University, Faculty of Arts and Sciences, Department of Chemistry, TR-25240-Erzurum, Turkey. igulcin@atauni.edu.tr
Daştan
Arif
A
D000975:Antioxidants / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D019281:Dimerization; D004655:Emulsions; D016166:Free Radical Scavengers / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D019787:Linoleic Acid / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D019800:Phenol / Q000138:chemical synthesis* / Q000737:chemistry; D013861:Thiocyanates / Q000737:chemistry
D000975:Antioxidants; D002614:Chelating Agents; D004655:Emulsions; D016166:Free Radical Scavengers; D013861:Thiocyanates; D019800:Phenol; C103724:ferric thiocyanate; D019787:Linoleic Acid; D006861:Hydrogen Peroxide; D007501:Iron