Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes.
To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.
Yoo
Choung Ryong
CR
Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, and BK21 CLS, Seoul National University School of Dentistry, 28 Yeonkun-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea.
Yeo
In-Sung
IS
Park
Ko Eun
KE
Park
Ji Hun
JH
Lee
Seung Jin
SJ
Park
Won Ho
WH
Min
Byung-Moo
BM
D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D002686:Chitin / Q000737:chemistry*; D004563:Electrochemistry; D004817:Epidermis / Q000378:metabolism; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D047011:Silk / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D047011:Silk; D014867:Water; D002686:Chitin; D005349:Fibroins