title: Three new polyketide-terpenoid hybrids from Penicillium sp.
abstract: Three novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium minioluteum strain. Their structures were determined by NMR spectroscopic analyses and X-ray crystallography. The proposed biosynthetic pathway including a unique retro-Claisen migration of methyl carbonate correlates the three compounds with berkeleydione and berkeleytrione.
authors.affiliation: Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.
authors.forename: Motoo
authors.initials: M
authors.lastname: Iida
authors.forename: Takashi
authors.initials: T
authors.lastname: Ooi
authors.forename: Keijiro
authors.initials: K
authors.lastname: Kito
authors.forename: Sanae
authors.initials: S
authors.lastname: Yoshida
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
authors.forename: Takenori
authors.initials: T
authors.lastname: Kusumi
mesh_terms: D018360:Crystallography, X-Ray; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C528590:22-epoxyberkeleydione; D018942:Macrolides; D013729:Terpenes; C493366:berkeleydione; C493367:berkeleytrione; C528591:miniolutelide A; C528592:miniolutelide B