In vitro antifungal activity of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole derivatives.
OBJECTIVE
The aim of the study was the determination of antifungal activity of new of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole (AOAT) derivatives against Candida albicans, non-Candida albicans.


METHODS
The determination of antifungal activity AOATs against 20 Candida albicans, 18 non-Candida albicans was performed. Isolates were from different ontocenoses of patients were used for tests. AOATs were synthesized at Department of Chemistry University of Agriculture in Lublin.


RESULTS
The mean MIC of AOATs against Candida albicans strains was 141.625 (37.5-200) mg/L on Sabouraud's medium (SB). The mean MIC of AOATs against non-Candida albicans strains was 153.3 (50-200) mg/L.


CONCLUSIONS
It seems that AOATs exert potent antifungal activity against the yeast-like fungi strains in vitro.
Lukaszuk
C
C
Department of General Nursing, Medical Academy in Białystok, Poland. cecylia.lukaszuk@wp.pl
Krajewska-Kułak
E
E
Niewiadomy
A
A
Stachowicz
J
J
Głaszcz
U
U
Oksiejczuk
E
E
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D013830:Thiadiazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D013830:Thiadiazoles