title: Pulmonary sequestration with elevated serum level of progastrin-releasing peptide.
abstract: A 74-year-old woman with rheumatoid arthritis was referred for a mass incidentally noted on chest radiograph. Chest CT scan showed cystic lesions in the right lower lobe. The lesion was evaluated as bronchiectasis, and she was followed up. Three years after the initial presentation, the appearance of the lesion had changed significantly and an elevated air-fluid level in the cystic structures was shown on chest CT scan. The preoperative serum progastrin-releasing peptide (proGRP) level was elevated (108.0 pg/ml; normal: <50 pg/ml). Histopathological specimen obtained by standard lower lobectomy confirmed that the lesion was an intralobar pulmonary sequestration. In the resected lobe, there was no malignant finding, but there were neuroendocrine tumorlet cells, which were positive for proGRP. One month after the resection, the serum proGRP level returned to normal. No pulmonary sequestration with high levels of proGRP has been reported, and this is the first case with elevated serum levels of proGRP.
authors.affiliation: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Masuko
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kikuchi
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kondo
authors.forename: Morio
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
mesh_terms: D000368:Aged; D001998:Bronchopulmonary Sequestration / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011013:Pneumonectomy; D011994:Recombinant Proteins / Q000097:blood
chemical_list: D010446:Peptide Fragments; D010455:Peptides; D011994:Recombinant Proteins; C087079:pro-gastrin-releasing peptide (31-98)