Autoimmune Hepatitis and PSC Connection.
This article describes the connection between autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). The two conditions have chronicity, liver inflammation, and a positive autoimmune serology in common; they differ in terms of gender distribution and bile duct damage. There is evidence suggesting that AIH and PSC are immune-mediated diseases. PSC and AIH could lie within the spectrum of the same disease process. Future studies should determine how frequently AIH evolves to PSC.
Vergani
Diego
D
Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, Denmark Hill, London SE5 9RS, UK. diego.vergani@kcl.ac.uk
Mieli-Vergani
Giorgina
G
D015209:Cholangitis, Sclerosing / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D019693:Hepatitis, Autoimmune / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D006801:Humans