title: A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus.
abstract: BACKGROUND
  Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP.
  
  
  OBJECTIVE
  To compare the effectiveness of clobetasol and tacrolimus in the topical management of OLP.
  
  
  METHODS
  In this randomized comparative double-blind study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited. The patients were divided into 2 groups to receive clobetasol 0.05% or tacrolimus 0.1% ointment and were treated for 6 weeks.
  
  
  RESULTS
  The profiles of mean lesion sizes and mean pain measures did not differ between the tacrolimus and clobetasol treatment groups.
  
  
  CONCLUSIONS
  We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP.
authors.affiliation: Oral Medicine, Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, USA. lida-radfar@ouhsc.edu
authors.forename: Lida
authors.initials: L
authors.lastname: Radfar
authors.forename: Robert C
authors.initials: RC
authors.lastname: Wild
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Suresh
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002990:Clobetasol / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D016559:Tacrolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D009824:Ointments; D002990:Clobetasol; D016559:Tacrolimus