[Role of gamma delta T cells in the prevention and treatment of allergic bronchial asthma by desensitization of allergen nebulization].
OBJECTIVE
To explore the role of gammadeltaT cells in the pathogenesis of allergic bronchial asthma.


METHODS
Forty patients with Der.p and Der f allergy and partly-controlled asthma were involved in a random study. Besides the fact that all patients were treated with same basic treatment. Patients in group A were nebulized with 5 mL normal saline while group B with specific allergen twice a week for six months. The percentage of gammadeltaT cells in peripheral blood and induced sputum and the percentage of IL-4(+) and IFN-gamma(+) gammadeltaT cells were detected by flow cytometry(FCM) before and after treatment.


RESULTS
The percentage of gammadeltaT cells in group B decreased after treatment, and the percentage of IFN-gamma(+) gammadeltaT cells in both peripheral blood and induced sputum increased significantly in group B than that in group A.


CONCLUSIONS
gammadeltaT cells, which may participate in the pathogenesis of bronchial asthma, may contribute to the prevention and treatment of bronchial asthma by desensitization of allergen nebulization.
Jiang
Xiao-hong
XH
Institute of Respiratory Disease, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. j_doctor@126.com
Li
Chao-qian
CQ
He
Ying
Y
Deng
Jia-zhen
JZ
Qin
Hui-qing
HQ
Liang
Guo-rong
GR
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000494:pharmacology* / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D003888:Desensitization, Immunologic; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
D000485:Allergens; D015847:Interleukin-4; D007371:Interferon-gamma