Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro.
The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and anti-platelet commercial monomeric polyphenol-resveratrol. The effects of extracts on platelet adhesion to collagen, collagen-induced platelet aggregation and on the production of O2-* in resting platelets and platelets stimulated by a strong platelet agonist-thrombin were studied. The in vitro experiments have shown that all three tested extracts (5-50 microg/ml) rich in polyphenols reduce platelet adhesion, aggregation and generation of O2-* in blood platelets. Comparative studies indicate that all three plant extracts were found to be more reactive in reduction of platelet processes than the solution of pure resveratrol. The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved.
Olas
Beata
B
Department of General Biochemistry, University of Lodz, 90-237 Lodz, Poland. olasb@biol.uni.lodz.pl
Wachowicz
Barbara
B
Tomczak
Anna
A
Erler
Joachim
J
Stochmal
Anna
A
Oleszek
Wieslaw
W
D000328:Adult; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism; D003094:Collagen / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology; D006801:Humans; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D046936:Photinia; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D000077185:Resveratrol; D012639:Seeds; D013267:Stilbenes / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology; D027843:Vitis / Q000737:chemistry; D027623:Yucca
D000975:Antioxidants; D005419:Flavonoids; D006490:Hemostatics; D010636:Phenols; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D059808:Polyphenols; D013267:Stilbenes; D013481:Superoxides; D003094:Collagen; D013917:Thrombin; D000077185:Resveratrol