title: Takayasu arteritis presenting as cerebral aneurysms in an 18 month old: A case report.
abstract: BACKGROUND
  Central nervous system involvement occurs in as many as twenty percent of Takayasu arteritis cases. When central nervous system disease is present, it typically manifests as cerebral ischemia or stroke. There are rare reports of intracranial aneurysms in adults with Takayasu arteritis, but none in children.
  
  
  METHODS
  We describe a case of Takayasu arteritis in an 18 month old girl who presented with a ruptured cerebral aneurysm. Full body magnetic resonance angiography revealed bilateral iliac, pelvic and intragluteal aneurysms, irregular terminal aorta, and stenotic renal arteries. Iliac vessel biopsy showed a lymphocytic infiltrate and giant cells localized to the internal elastica.
  
  
  CONCLUSIONS
  This case highlights cerebral aneurysm as a highly unusual initial manifestation of Takayasu arteritis and demonstrates the challenges of diagnosis, treatment, and assessment of response to therapy in TA in children.
authors.affiliation: Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. smithsa@email.chop.edu.
authors.forename: Pamela F
authors.initials: PF
authors.lastname: Weiss
authors.forename: Diana A
authors.initials: DA
authors.lastname: Corao
authors.forename: Avrum N
authors.initials: AN
authors.lastname: Pollock
authors.forename: Terri H
authors.initials: TH
authors.lastname: Finkel
authors.forename: Sabrina E
authors.initials: SE
authors.lastname: Smith