[Prognostic factors of pneumococcal meningitis. Retrospective study of 31 cases].
OBJECTIVE
Our aim was to study the susceptibility of Streptococcus pneumoniae to antibiotics in patients with pneumococcal meningitis and to search for the prognosis factors in those patients.


METHODS
We have studied retrospectively 31 cases of pneumococcal meningitis. Comparaisons were performed with univariate analysis.


RESULTS
The mean age was 36.7 +/- 20.5 years (ranged: 9 and 78 years). The sex ratio was 3,4. The susceptibility of Streptococcus pneumoniae to penicillin G was affected in 10 cases (33% of isolated pneumococcus. The MIC to penicillin G was > or =2 in only one case. The hospital mortality was 26% (8/31). With univariate analysis, factors associated with death were: age > or =55 years (Ss p= 0,006, OR: 17.2 IC95%: 2.3-134), albuminorachie > or = 7 g/l (p = 0.002, OR: 22; IC95%: 1.9-2.51), shock (p = 0.031, OR: 6.7; IC95%: 1.05-42) and Glasgow Coma Score (GCS) < or =8 (p = 0.001, OR: 20; IC95%: 2.68-149).


CONCLUSIONS
No susceptibility to penicillin G is not associated with a worse outcome in patients with pneumococcal meningitis. An age > or =55 years, albuminorachie > or =7 g/l shock and Glasgow Coma Score < or =8 at admission were determinant of the prognosis in our study.
Kallel
H
H
Service de Réanimation Médicale, CHU Habib Bourguiba, Sfax, Tunisie.
Mâaloul
I
I
Mahjoubi
F
F
Dammak
H
H
Ghorbel
H
H
Chelly
H
H
Ksibi
H
H
Ben Hamida
C
C
Rekik
N
N
Ben Jemaa
M
M
Hammami
A
A
Bouaziz
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects