Echinopines A and B: sesquiterpenoids possessing an unprecedented skeleton from Echinops spinosus.
Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOESY correlations and a simulation analysis. A plausible biosynthetic pathway for echinopane was discussed.
Dong
Mei
M
Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, People's Republic of China.
Cong
Bin
B
Yu
Shu-Hong
SH
Sauriol
Françoise
F
Huo
Chang-Hong
CH
Shi
Qing-Wen
QW
Gu
Yu-Cheng
YC
Zamir
Lolita O
LO
Kiyota
Hiromasa
H
D004354:Drug Screening Assays, Antitumor; D031182:Echinops Plant / Q000737:chemistry*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D012717:Sesquiterpenes; C527602:echinopine A; C527604:echinopine B