Distribution of malignant lymphoma in Japan: analysis of 2260 cases, 2001-2006.
The World Health Organization classification was used to conduct an analysis of geographic, age, sex, and lesion primarily biopsied/resected distribution of 2260 lymphoid neoplasms diagnosed during 2001-2006 throughout Japan. B-cell neoplasms accounted for 65% of all lymphoid neoplasms, T/natural killer (T/NK)-cell neoplasms for 25% and Hodgkin lymphoma for 7%. The most common type was diffuse large B-cell lymphoma (DLBCL, 33%), followed by follicular lymphoma (18%), and adult T-cell leukemia/lymphoma (ATLL, 10%). The high rate of 18% for follicular lymphoma was similar to that in Western countries (11-33%). T/NK-cell neoplasms accounted for a higher percentage of lymphoid neoplasms in Kyushu (30%) and Okinawa (38%) compared with other areas of Japan (18-20%). Among T/NK-cell neoplasms, ATLL was the most common type in Okinawa (54%) and Kyushu (59%). Extranodal NK/T cell lymphoma was the second most common type of T/NK-cell neoplasms in Okinawa (15%). This epidemiological study shows that the distribution patterns of malignant lymphoma differ especially in Kyushu and Okinawa, the endemic area of human T-cell leukemia/lymphoma virus type 1.
Aoki
Ryosuke
R
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
Karube
Kennosuke
K
Sugita
Yasuo
Y
Nomura
Yuko
Y
Shimizu
Kay
K
Kimura
Yoshizo
Y
Hashikawa
Keiko
K
Suefuji
Nobuko
N
Kikuchi
Masahiro
M
Ohshima
Koichi
K
D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology / Q000473:pathology; D008223:Lymphoma / Q000737:chemistry / Q000453:epidemiology* / Q000473:pathology; D008224:Lymphoma, Follicular / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology
D014408:Biomarkers, Tumor