title: Borderline personality features possibly related to cingulate and orbitofrontal cortices dysfunction due to schizencephaly.
abstract: Prefrontal cortex dysfunction has been associated with a series of behavioral symptoms, such as impulsivity and affective instability, which are the defining features of several personality disorders, notably, borderline personality disorder. We report on a 27-year-old patient with schizencephaly in the right frontal lobe (cingulate cortex lesion and secondary orbitofrontal cortex dysfunction) presenting with prominent borderline features and compromise of executive functions, decision-making and attention. We hypothesize that the personality disorder of our patient could be related to cingulate cortex lesion and secondary orbitofrontal cortex dysfunction associated with schizencephaly.
authors.affiliation: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Felipe Filardi
authors.initials: FF
authors.lastname: da Rocha
authors.forename: Leandro
authors.initials: L
authors.lastname: Malloy-Diniz
authors.forename: Karla Cristhina Alves
authors.initials: KC
authors.lastname: de Sousa
authors.forename: Hugo Alejandro Cano
authors.initials: HA
authors.lastname: Prais
authors.forename: Humberto
authors.initials: H
authors.lastname: Correa
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005625:Frontal Lobe / Q000002:abnormalities* / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000002:abnormalities* / Q000503:physiopathology; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000175:diagnosis; D009483:Neuropsychological Tests