[Medulloblastoma in pediatrics. Current prognosis and treatment].
In Mexico, Central Nervous System (CNS) tumors are the third most common childhood cancers. Medulloblastoma constitutes 20% of the primary CNS tumors and 40% of all cerebellar tumors, the single most common brain tumor among children. It originates over the external granular layer that normally migrates from the vermis to the surface of the cerebellum hemispheres and from there to the deep portions of the internal granular layer. These tumors infiltrate profusely the cerebellar cortex. The dissemination process can occur through the spinal fluid with seeding along the subarachnoidal space and around the spinal chord They eventually produce metastasis mainly to bone, liver, and bone marrow. There is a group of well identified prognostic factors that are relevant for each individual patient and that can be applied for multidisciplinary treatment purposes. The objective of the present review is to emphasize on new research findings and the overall survival that can be achieved with modern treatment programs.
Rivera-Luna
Roberto
R
Hematooncología Pediátrica, Instituto Nacional de Pediatriá, SSA, México DF, México. riveraluna@infosel.net.mx
Niembro-Zúñiga
Ana María
AM
Zarco
Amador
A
Marhx-Bracho
A
A
Cárdenas-Cardós
Rocío
R
Olaya-Vargas
Alberto
A
Rueda-Franco
Fernando
F
Martínez-Avalos
Armando
A
D002528:Cerebellar Neoplasms / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008527:Medulloblastoma / Q000628:therapy*; D011379:Prognosis