Experimental study of hepatoprotective activity of hydroxymethyluracil.
Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect.
Mirsaev
T R
TR
Bashkir State Medical University, Ufa, Russia. mirsaev@mail.ru
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000082:Acetaminophen; C008055:5-hydroxymethyluracil; D010432:Pentoxyl; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase