title: Phosphatases at the heart of FoxO metabolic control.
abstract: FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.
authors.affiliation: McGill Cancer Centre, McGill University, Montréal, PQ, H3G 1Y6, Canada. michel.tremblay@mcgill.ca <michel.tremblay@mcgill.ca>
authors.forename: Michel L
authors.initials: ML
authors.lastname: Tremblay
authors.forename: Vincent
authors.initials: V
authors.lastname: Giguère
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000209:etiology*; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D008660:Metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051858:Forkhead Transcription Factors; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases