title: Regulation of SIRT6 protein levels by nutrient availability.
abstract: Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability.
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Kanfi
authors.forename: Ronnie
authors.initials: R
authors.lastname: Shalman
authors.forename: Victoria
authors.initials: V
authors.lastname: Peshti
authors.forename: Shmuel N
authors.initials: SN
authors.lastname: Pilosof
authors.forename: Yosi M
authors.initials: YM
authors.lastname: Gozlan
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Pearson
authors.forename: Batya
authors.initials: B
authors.lastname: Lerrer
authors.forename: Danesh
authors.initials: D
authors.lastname: Moazed
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Marine
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
authors.forename: Haim Y
authors.initials: HY
authors.lastname: Cohen
mesh_terms: D000818:Animals; D002460:Cell Line; D005502:Food; D005508:Food Deprivation; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D051381:Rats; D011916:Rats, Inbred F344; D037761:Sirtuins / Q000378:metabolism*; D013816:Thermodynamics; D016159:Tumor Suppressor Protein p53
chemical_list: D016159:Tumor Suppressor Protein p53; C501860:Sirt6 protein, mouse; C516592:SIRT6 protein, human; D037761:Sirtuins