title: Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging.
abstract: To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with (99m)Tc (technetium) and administered into mice bearing MICA-positive human ovarian epithelial carcinoma line SKOV3. Measurement of organ-specific radioactivity showed that tumor accumulated radioactivity continuously, while the uptake in the other organs decreased over time. Scintigram showed that the tumor became clearly visible at 24h post-injection of radio-labeled 10C6 mAb. These results suggest that MICA is a promising target for tumor imaging and mAb 10C6 may be used clinically for early tumor diagnosis.
authors.affiliation: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, China.
authors.forename: Bixia
authors.initials: B
authors.lastname: Tang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Hao
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.forename: Lianxian
authors.initials: L
authors.lastname: Cui
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D015395:Histocompatibility Antigens Class I; D015609:Organotechnetium Compounds