title: Solid-phase parallel synthesis of phosphite ligands.
abstract: Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.
authors.affiliation: Van 't Hoff Institute of Molecular Sciences, University of Amsterdam, The Netherlands.
authors.forename: Bert H G
authors.initials: BH
authors.lastname: Swennenhuis
authors.forename: Ruifang
authors.initials: R
authors.lastname: Chen
authors.forename: Piet W N M
authors.initials: PW
authors.lastname: van Leeuwen
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Paul C J
authors.initials: PC
authors.lastname: Kamer
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D009943:Organophosphorus Compounds; D017905:Phosphites; C434331:phosphoramidite