Synthesis, characterization and hypoglycemic activity of Zn(II), Cd(II) and Hg(II) complexes with glibenclamide.
A series of group 12 elements for Zn(II), Cd(II), Hg(II) complexes of glibenclamide were synthesized and characterized using various spectroscopic techniques and magnetic moments. The complexes exhibited significant activity against gram-negative and gram-positive bacteria species. Zn(II) complex showed remarkable hypoglycemic activity whereas Cd(II) and Hg(II) complexes exhibited antibacterial activity.
Rasheed
Khalid
K
Department of Chemistry, Quaid-i-Azam University.
Tariq
Muhammad Ilyas
MI
Munir
Christy
C
Hussain
Ishtiaq
I
Siddiqui
Hamid Latif
HL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002104:Cadmium / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005905:Glyburide / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008628:Mercury / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D015032:Zinc / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D002104:Cadmium; D008628:Mercury; D015032:Zinc; D005905:Glyburide