Occupation and lymphoid malignancies: results from a French case-control study.
OBJECTIVE
Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM).


METHODS
We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews.


RESULTS
Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association.


CONCLUSIONS
The results support the hypothesis that farming plays a role in most types of LM.
Orsi
Laurent
L
INSERM, U754, Villejuif Cedex, France. orsi@vjf.inserm.fr
Troussard
Xavier
X
Monnereau
Alain
A
Berthou
Christian
C
Fenaux
Pierre
P
Marit
Gerald
G
Soubeyran
Pierre
P
Huguet
Françoise
F
Milpied
Noel
N
Leporrier
Michel
M
Hemon
Denis
D
Clavel
Jacqueline
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004651:Employment / Q000706:statistics & numerical data; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D009790:Occupations / Q000706:statistics & numerical data*; D012307:Risk Factors