Mps1 checks up on chromosome attachment.
The protein kinase Mps1, a crucial regulator of the spindle-assembly checkpoint, now turns out to be essential for correcting errors in chromosome attachment (Jelluma et al., 2008). Mps1 exerts this effect by regulating the activity of the Aurora B kinase through phosphorylation of its partner protein Borealin.
Hauf
Silke
S
Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tuebingen, Germany. silke.hauf@tuebingen.mpg.de
D064107:Aurora Kinase B; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002877:Chromosomes, Human / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011505:Protein-Tyrosine Kinases; D008941:Spindle Apparatus / Q000378:metabolism*
C490157:CDCA8 protein, human; D018797:Cell Cycle Proteins; D011505:Protein-Tyrosine Kinases; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; C075840:TTK protein, human