Analysis of antibiotic resistance markers in Chlamydia trachomatis clinical isolates obtained after ineffective antibiotic therapy.
Antibiotic resistance markers were analyzed in C. trachomatis clinical isolates obtained after ineffective therapy of urogenital chlamydiasis with fluoroquinolones and macrolides. Heterotypical resistance to fluoroquinolones and macrolides was detected in all clinical isolates. No significant mutations in the target genes were detected.
Shkarupeta
M M
MM
Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow.
Lazarev
V N
VN
Akopian
T A
TA
Afrikanova
T S
TS
Govorun
V M
VM
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy / Q000382:microbiology; D024841:Fluoroquinolones / Q000627:therapeutic use*; D005798:Genes, Bacterial / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D052801:Male Urogenital Diseases / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D005819:Genetic Markers; D018942:Macrolides