Effects of the polysaccharide fraction of Urtica fissa on castrated rat prostate hyperplasia induced by testosterone propionate.
A crude polysaccharide fraction of Urtica fissa roots and stems (UFP) was obtained by water extraction and ultrafiltration, and its effect on castrated rat prostate hyperplasia induced by testosterone propionate was evaluated by the volume index, wet and dry weight index and histopathological tests. Results showed that the crude polysaccharide fraction significantly inhibited prostatic hyperplasia in animal models at doses of 62.5, 125, 250 mg/kg body wt. (administered orally). Treatment with UFP at 62.5 mg/kg body wt. decreased the volume index by 32%, the wet weight index by 17% and the dry weight index by 23%, respectively. In the high-dose group (UFP at 250 mg/kg body wt.), the indexes of volume, wet weight and dry weight decreased further by 37%, 25% and 33%, respectively. Histopathological examination showed that proliferation of prostatic epithelial cells and fibrotic tissues were significantly inhibited.
Zhang
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Beijing Institute of Radiation Medicine, Taiping Road 27, Beijing 100850, China. qinglz@yahoo.com
Li
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Liu
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Li
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Yuan
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Song
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Wu
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D000818:Animals; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D008297:Male; D009919:Orchiectomy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011470:Prostatic Hyperplasia / Q000139:chemically induced* / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D043343:Testosterone Propionate / Q000009:adverse effects*; D027003:Urticaceae / Q000737:chemistry*
D010936:Plant Extracts; D011134:Polysaccharides; D043343:Testosterone Propionate