Imbalance in the antioxidant defense system as a possible cause of decreased compensatory and adaptive reserves in youths with mitral valve prolapse.
An imbalance in the first line of the antioxidant defence and hyperactivity of the glutathione-dependent system were revealed in 137 youths with mitral valve prolapse. Increased activities of superoxide dismutase and glutathione reductase (by 6 and 1.82-2.10 times, respectively) can serve as an additional diagnostic criterion of decreased compensatory reserves in patients with mitral valve prolapse.
Chepurnenko
S A
SA
Rostov State Medical University, Rostov Regional Clinical Hospital, Rostov Regional Center of Cardiology and Cardiovascular Surgery, Russia. anton_chepurnenk@mail.ru
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000201:enzymology / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase