Study of hypoxia-induced expression of HIF-1alpha in retina pigment epithelium.
It was shown that the expression of HIF-1alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1alpha in RPE. It can be an important step in choriodal neovascularization.
Yanjun
Zeng
Z
Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China. yjzeng@bjpu.edu.cn
Guangyu
Li
L
Bin
Fan
F
Qing
Wang
W
Ving
Jie
J
Aizhen
Liu
L
D000199:Actins / Q000235:genetics / Q000378:metabolism; D000328:Adult; D001483:Base Sequence; D020256:Choroidal Neovascularization / Q000209:etiology; D017931:DNA Primers / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010857:Pigment Epithelium of Eye / Q000378:metabolism*
D000199:Actins; D017931:DNA Primers; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit