Hepatocellular carcinoma presenting as neutrophilic leukaemoid reaction--a rare entity.
Leukaemoid reaction is a rare, growth factor-driven, paraneoplastic manifestation of hepatocellular carcinoma. It may masquerade as the neutrophilic chronic myeloid leukaemia or as chronic neutrophilic leukaemia. A 52-year-old male presented with hepatosplenomegaly and severe leucocytosis. He had progressive leucocytosis, neutrophil alkaline phosphatase score elevated, liver function tests altered. FNAC from the mass in the liver revealed features of moderately differentiated hepatocellular carcinoma. The patient deteriorated within two weeks and died thereafter.
Tilak
Vijai
V
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005.
Rai
Madhukar
M
Singh
V P
VP
Rai
Amit Kumar
AK
Raman
Rajiva
R
D000469:Alkaline Phosphatase / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007955:Leukemoid Reaction / Q000175:diagnosis* / Q000473:pathology; D007964:Leukocytosis / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils
D000469:Alkaline Phosphatase