title: Correlations between coding and contiguous non-coding sequences in isochore families from vertebrate genomes.
abstract: Many years ago compositional correlations were found to hold between coding and contiguous non-coding sequences. These correlations were essentially studied in whole genomes of mammals, which are characterized by strong compositional heterogeneities. Here we investigated whether these correlations also hold within the much more homogeneous isochore families. This point was checked not only in the case of mammals, but also in that of phylogenetically distant vertebrates, which are characterized by very different compositional patterns. Indeed, these are remarkably different in cold- and warm-blooded vertebrates. Fish genomes, for instance, are much more homogeneous than those of mammals and birds. The compositional correlations between coding sequences and the corresponding introns, or their 5' and 3' flanking regions, were studied in the isochore families of the fully sequenced genomes from four fishes (Brachydanio rerio, Oryzias latipes, Gasterosteus aculeatus and Tetraodon nigroviridis), human and chicken.
authors.affiliation: Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Costantini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D024509:3' Flanking Region; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D005091:Exons; D005399:Fishes; D016678:Genome; D006801:Humans; D007438:Introns; D032085:Isochores; D008957:Models, Genetic
chemical_list: D032085:Isochores