title: MR imaging of prostate after treatment with high-intensity focused ultrasound.
abstract: OBJECTIVE
  To prospectively evaluate magnetic resonance (MR) imaging findings after high-intensity focused ultrasound (HIFU) treatment of the prostate and to correlate them with clinical and histologic findings.
  
  
  METHODS
  Local ethics committee approval and informed consent were obtained. Fifteen consecutive men aged 46-70 years with organ-confined prostate cancer underwent ultrasonographically guided ablation of the whole prostate. Postoperative MR images were obtained within 1 month (12 patients), at 1-3 months (five patients), and in all patients at 6 months. Prostate volume was measured on T2-weighted images, and enhancing tissue was measured on dynamic images after intravenous administration of gadopentetate dimeglumine. Prostate-specific antigen (PSA) level was measured at regular intervals, and transrectal biopsy was performed in each patient at 6 months after treatment.
  
  
  RESULTS
  Initial post-HIFU images showed a central nonenhancing area, surrounded by an enhancing rim. At 6 months, the prostate was small (median volume reduction, 61%) and was of predominantly low signal intensity on T2-weighted images. The volume of prostate enhancing on the initial posttreatment image correlated well with serum PSA level nadir (Spearman r = 0.90, P < .001) and with volume at 6 months (Pearson r = 0.80, P = .001). The three patients with the highest volume of enhancing prostate at the initial posttreatment acquisition had persistent cancer at 6-month biopsy.
  
  
  CONCLUSIONS
  MR imaging results of the prostate show a consistent sequence of changes after treatment with HIFU and can provide information to the operator about completeness of treatment.
authors.affiliation: Department of Imaging, University College London Hospitals NHS Foundation Trust, England. alexkirkham@yahoo.com
authors.forename: Alexander P S
authors.initials: AP
authors.lastname: Kirkham
authors.forename: Mark
authors.initials: M
authors.lastname: Emberton
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Hoh
authors.forename: Rowland O
authors.initials: RO
authors.lastname: Illing
authors.forename: A Alex
authors.initials: AA
authors.lastname: Freeman
authors.forename: Clare
authors.initials: C
authors.lastname: Allen
mesh_terms: D000368:Aged; D001706:Biopsy; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA