title: Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.
abstract: Following our previous studies in the field of anticonvulsant agents, we planned a one-pot solution-phase parallel synthesis (SPPS) of a small library of new 1,2,3,4-tetrahydroisoquinoline derivatives. The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Università di Messina, Messina, Italy. rgitto@pharma.unime.it
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gitto
authors.forename: Eleonora
authors.initials: E
authors.lastname: Francica
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
authors.forename: Francesca
authors.initials: F
authors.lastname: Scicchitano
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D020195:Epilepsy, Reflex / Q000517:prevention & control; D005260:Female; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012996:Solutions; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D007202:Indicators and Reagents; D012996:Solutions; D044005:Tetrahydroisoquinolines