title: EPA's 2006 human-subjects rule for pesticide experiments.
abstract: Arguing that the 2006 Environmental Protection Agency (EPA) human-subjects rule allows use of unethical third-party research (on pregnant women and children) in setting pesticide regulations, this article first (a) provides a brief history of U.S. pesticide regulation, particularly regarding childhood safety. Next it (b) outlines ethical and scientific loopholes in the 2006 EPA rule; (c) shows how the Human Subjects Review Board, mandated by the 2006 rule, has been implemented in flawed ways; and (d) illustrates that one source of problems with the rule may be influence by those with conflicts of interest.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. kshrader@nd.edu
authors.forename: Kristin
authors.initials: K
authors.lastname: Shrader-Frechette
mesh_terms: D002617:Chemical Industry / Q000331:legislation & jurisprudence / Q000592:standards; D002669:Child Welfare / Q000941:ethics / Q000331:legislation & jurisprudence; D002675:Child, Preschool; D016265:Conflict of Interest; D028744:Ethics Committees, Research / Q000331:legislation & jurisprudence / Q000592:standards; D005260:Female; D033161:Government Regulation; D019983:Guideline Adherence / Q000941:ethics* / Q000331:legislation & jurisprudence / Q000592:standards; D006805:Human Experimentation / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards*; D006801:Humans; D010575:Pesticides / Q000633:toxicity*; D011057:Politics; D011247:Pregnancy; D037841:Pregnant People; D018675:Toxicity Tests / Q000941:ethics / Q000592:standards; D014481:United States; D014484:United States Environmental Protection Agency / Q000941:ethics / Q000592:standards*
chemical_list: D010575:Pesticides