title: [Continuous intraspinal ceftazidime administration in a case for treatment of purulent meningitis].
abstract: OBJECTIVE
  To investigate the feasibility of continuous intraspinal ceftazidime administration for treatment of purulent meningitis due to Achromobacter infection.
  
  
  METHODS
  A patient with established diagnosis of purulent meningitis due to Achromobacter infection was admitted, who failed to respond favorably to a 3-day ceftazidime treatment administered intravenously. Continuous intraspinal ceftazidime administration at the dose of 0.2 g/d was then attempted through a catheter placed in the cisterna magna in addition to intravenous ceftazidime for 3 days, which resulted in obvious relief of the symptoms. The catheter was subsequently withdrawn, and the patient received further treatment with additional intravenous ceftazidime for a week.
  
  
  RESULTS
  The symptoms of purulent meningitis was significantly improved after a 3-day continuous intraspinal ceftazidime administration, and the patient was eventually cured after completion of the treatment course. Intrathecal ceftazidime was also attempted previously but failed due to intolerance of pains in the legs. No relapse was observed in this case 3 months after the discharge.
  
  
  CONCLUSIONS
  Continuous intraspinal ceftazidime administration can be effective and safe for treatment of purulent meningitis.
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yinjiajia@263.net
authors.forename: Jia
authors.initials: J
authors.lastname: Yin
authors.forename: Tian-ming
authors.initials: TM
authors.lastname: Lü
authors.forename: Xiao-jia
authors.initials: XJ
authors.lastname: Liu
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Su-yue
authors.initials: SY
authors.lastname: Pan
mesh_terms: D042402:Achromobacter; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D002442:Ceftazidime / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime