Chiral N-phosphonyl imine chemistry: asymmetric aza-Henry reaction.
A series of chiral N-phosphonyl imines have been synthesized and utilized successfully in asymmetric aza-Henry reaction. The chiral auxiliary was optimized for this reaction by varying different R groups on the nitrogen atoms. The reaction is convenient to perform to give excellent yields and good diastereoselectivities. The absolute stereochemistry was unambiguously determined by converting a resulting vicinal nitroamine into its N-Boc derivative which serves as a known compound.
Kattuboina
Adiseshu
A
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA.
Kaur
Parminder
P
Ai
Teng
T
Li
Guigen
G
D001372:Aza Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism
D001372:Aza Compounds; D007097:Imines