Corticobasal degeneration presenting with progressive conduction aphasia.
We report the case of a woman with primary progressive aphasia (PPA) presenting with conduction aphasia. Neurological findings showed bilateral finger tremor and signe de poignet figé in her right hand. Memory, orientation, and activities of daily living were well preserved. Linguistic examination showed severe impairment in repetition, fluent spontaneous speech with phonemic paraphasia, and relatively well preserved comprehension. Limb-kinetic apraxia and parkinsonism were not observed during the course of her illness. T1-weighted magnetic resonance imaging revealed severe atrophy of the left temporal lobe and dilatation of the left Sylvian fissure. Neuropathological findings demonstrated the most severe atrophy in the left superior temporal gyrus and Gallyas-Braak-positive or phosphorylated tau-immunoreactive cytoskeletal structures, which were consistent with corticobasal degeneration (CBD). We speculate that the progressive conduction aphasia of our patient might have been caused by left temporal lobe impairment. We suggest that progressive conduction aphasia may be a feature of CBD presenting with PPA.
Kimura
Noriyuki
N
Department of Neurology and Neuromuscular Disorders, Oita University, Faculty of Medicine, Oita, Japan. noriyuki@med.oita-u.ac.jp
Kumamoto
Toshihide
T
Hanaoka
Takuya
T
Hazama
Yusuke
Y
Nakamura
Kenichiro
K
Arakawa
Ryuki
R
D000368:Aged; D018886:Aphasia, Conduction / Q000209:etiology*; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins