title: Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema.
abstract: We describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. We postulate that these imaging findings were the result of intramyelinic edema, previously described in experimental animal models of isoniazid toxicity.
authors.affiliation: Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
authors.forename: Michael
authors.initials: M
authors.lastname: Hawkes
authors.forename: Ian
authors.initials: I
authors.lastname: Kitai
authors.forename: Susan
authors.initials: S
authors.lastname: Blaser
authors.forename: Eyal
authors.initials: E
authors.lastname: Cohen
authors.forename: Ari
authors.initials: A
authors.lastname: Bitnun
authors.forename: Joel
authors.initials: J
authors.lastname: Fluss
authors.forename: Dat
authors.initials: D
authors.lastname: Tran
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001772:Blood Cell Count; D001929:Brain Edema / Q000139:chemically induced* / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid