Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer.
OBJECTIVE
The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer.


METHODS
Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival.


RESULTS
Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival.


CONCLUSIONS
Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.
Chan
John K
JK
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Services, University of California, San Francisco School of Medicine, Helen Diller Family Comprehensive Cancer Center, 94143-1702, USA. chanjohn@obgyn.ucsf.edu
Kapp
Daniel S
DS
Cheung
Michael K
MK
Shin
Jacob Y
JY
Stieglitz
Deirdre
D
Husain
Amreen
A
Teng
Nelson N
NN
Berek
Jonathan S
JS
Osann
Kathryn
K
Guo
Hongyan
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000556:secondary; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D018426:SEER Program; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology