title: The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.
abstract: A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.
authors.affiliation: Laboratoire de Chimie Organique et Macromoléculaire, CNRS UMR 8009, Université de Lille 1, 59655 Villeneuve d'Ascq, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Queffélec
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bailly
authors.forename: Gladys
authors.initials: G
authors.lastname: Mbemba
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mouscadet
authors.forename: Zeger
authors.initials: Z
authors.lastname: Debyser
authors.forename: Myriam
authors.initials: M
authors.lastname: Witvrouw
authors.forename: Philippe
authors.initials: P
authors.lastname: Cotelle
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002460:Cell Line; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019428:HIV Integrase Inhibitors; D010666:Phenylpropionates; D013386:Succinates; C116091:fukiic acid; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1