Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets.
Ye
Hong
H
Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477-0776, USA.
Chen
Cailin
C
Zhang
Han-Cheng
HC
Haertlein
Barbara
B
Parry
Tom J
TJ
Damiano
Bruce P
BP
Maryanoff
Bruce E
BE
D001792:Blood Platelets / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000502:physiology; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D058925:Receptors, Purinergic P2Y12; D015398:Signal Transduction; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D009705:Nucleosides; C548576:P2RY12 protein, human; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D058925:Receptors, Purinergic P2Y12; D013777:Tetrazoles; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D002118:Calcium