Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum.
We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.
Tsuji
Brian T
BT
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Leonard
Steven N
SN
Rhomberg
Paul R
PR
Jones
Ronald N
RN
Rybak
Michael J
MJ
D000418:Albumins / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011485:Protein Binding; D044967:Serum / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000418:Albumins; D000900:Anti-Bacterial Agents