Synthesis of functionalized oxazolones by a sequence of Cu(II)- and Au(I)-catalyzed transformations.
A study concerning a two-step sequence leading to the formation of diversely 1,5-disubstituted oxazolones is described. The mild conditions employed allow the efficient and rapid synthesis of a variety of such compounds via an initial Cu(II)-catalyzed coupling of a bromoalkyne with a secondary tert-butyloxycarbamate followed by a Au(I)-catalyzed cycloisomerization of the N-alkynyl tert-butyloxycarbamates thus obtained.
Istrate
Florin M
FM
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique, 91128 Palaiseau, France.
Buzas
Andrea K
AK
Jurberg
Igor Dias
ID
Odabachian
Yann
Y
Gagosz
Fabien
F