Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.
Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.
Früh
M
M
Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
Zhou
W
W
Zhai
R
R
Su
L
L
Heist
R S
RS
Wain
J C
JC
Nishioka
N S
NS
Lynch
T J
TJ
Shepherd
F A
FA
Christiani
D C
DC
Liu
G
G
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D016480:Helicobacter pylori / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D053508:Matrix Metalloproteinase 12 / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011795:Surveys and Questionnaires
D019278:Matrix Metalloproteinase 3; D020778:Matrix Metalloproteinase 2; D053508:Matrix Metalloproteinase 12; D020781:Matrix Metalloproteinase 1