Progressive multifocal leukoencephalopathy and CD4+ T-lymphocytopenia in a patient with Sjögren syndrome.
We report progressive multifocal leukoencephalopathy (PML) and CD4+ T-lymphocytopenia in a 71-year-old man with Sjögren syndrome (SjS). The patient was admitted to our hospital because of progressive dementia and gait disturbance. T2-weighted MR images showed high-intensity lesions in his left frontal white matter thalamus, cerebellum and brainstem. A pathological diagnosis of PML was made by brain biopsy. SjS is frequently accompanied with immunological complications; however, there are few reports on PML in patients with SjS. Recently, isolated CD4+ T-lymphocytopenia is reported to be one of the based immunological conditions associated with the development of PML. In the present case, CD4+ T-lymphocytopenia was also observed on admission, which is also associated with SjS.
Hayashi
Yuichi
Y
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan. hayashiy@gifu-u.ac.jp
Kimura
Akio
A
Kato
Shimon
S
Koumura
Akihiro
A
Sakurai
Takeo
T
Tanaka
Yuji
Y
Hozumi
Isao
I
Sunden
Yuji
Y
Orba
Yasuko
Y
Sawa
Hirofumi
H
Takahashi
Hitoshi
H
Inuzuka
Takashi
T
D000368:Aged; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D012859:Sjogren's Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D000086082:Viroporin Proteins
D054334:Viral Regulatory and Accessory Proteins; C042559:agnoprotein, polyomavirus; D000086082:Viroporin Proteins