A comparative study of stimulation of erythropoiesis during renal anemia with the preparation of antibodies against erythropoietin in ultralow doses and Recormon.
We compared the stimulatory effects of a preparation of antibodies against erythropoietin in ultralow doses (Poetam) and recombinant erythropoietin (Recormon) on erythropoiesis that was suppressed by carboplatin. Both drugs possessed high erythropoiesis-stimulating activity, which was manifested in an increase in the number of erythrokaryocytes and erythroid precursors in hemopoietic tissue and count of erythrokaryocytes and reticulocytes in the peripheral blood during postcytostatic recovery. Recormon produced a rapid and short-term stimulatory effect on the erythron. The effect of Poetam developed slowly, but persisted for a longer time.
Epshtein
O I
OI
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Sciences, Research-and-Production Company Materia Medica Holding, Moscow.
Dygai
A M
AM
Zhdanov
V V
VV
Sergeeva
S A
SA
Zyuz'kov
G N
GN
Udut
E V
EV
Khrichkova
T Yu
TY
Simanina
E V
EV
Gur'yantseva
L A
LA
Stavrova
L A
LA
Gol'dberg
E D
ED
D000740:Anemia / Q000097:blood / Q000188:drug therapy; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000276:immunology* / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins
D000906:Antibodies; D011994:Recombinant Proteins; D004921:Erythropoietin