A prospective study of passive smoking and risk of diabetes in a cohort of workers: the High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study.
OBJECTIVE
We investigated the impact of active smoking and exposure to passive smoke on the risk of developing diabetes.


METHODS
Data were analyzed from a cohort of participants in the High-Risk and Population Strategy for Occupational Health Promotion Study (HIPOP-OHP) conducted in Japan from 1999 to 2004. Active and passive smoking status in the workplace was evaluated at baseline.


RESULTS
Of 6,498 participants (20.9% women), a total of 229 diabetes cases were reported over a median 3.4 years of follow-up. In the workplace, compared with zero-exposure subjects, the multivariable-adjusted hazard ratios of developing diabetes were 1.81 (95% CI 1.06-3.08, P = 0.028) for present passive subjects and 1.99 (1.29-3.04, P = 0.002) for present active smokers.


CONCLUSIONS
In this cohort, exposure to passive smoke in the workplace was associated with an increased risk of diabetes after adjustment for a large number of possible confounders.
Hayashino
Yasuaki
Y
Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. hayasino-y@umin.net
Fukuhara
Shunichi
S
Okamura
Tomonori
T
Yamato
Hiroshi
H
Tanaka
Hideo
H
Tanaka
Taichiro
T
Kadowaki
Takashi
T
Ueshima
Hirotsugu
H
D000328:Adult; D000428:Alcohol Drinking; D001628:Beverages; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D004040:Dietary Carbohydrates; D005260:Female; D005500:Follow-Up Studies; D006293:Health Promotion; D006801:Humans; D007564:Japan; D008297:Male; D016272:Occupational Health; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D004040:Dietary Carbohydrates; D014028:Tobacco Smoke Pollution