Comparison of singleton and multiple-birth outcomes of infants born at or before 32 weeks of gestation.
OBJECTIVE
To compare the outcomes of multiple-birth and singleton very preterm infants who were admitted to neonatal intensive care units (NICUs).


METHODS
Three-level hierarchical generalized linear and hierarchical linear model analyses were used to compare the risk-adjusted outcomes of 3,242 infants born at or before 32 weeks of gestational age who were admitted to 24 Canadian NICUs in 2005.


RESULTS
With the exception of respiratory distress syndrome (RDS), multiple-birth infants were not at a higher risk than singleton birth infants for death, patent ductus arteriosus, necrotizing enterocolitis, chronic lung disease, severe intraventricular hemorrhage, severe (stages 3 or higher) retinopathy of prematurity, or nosocomial infection, after adjusting for perinatal risks and neonatal illness severity. In addition, multiple-birth infants did not have a more prolonged duration of neonatal intensive care unit stay, duration of length of continuous positive airway pressure use, duration of ventilation, or duration of oxygen use than did singletons. Multiple-birth infants had a higher incidence of RDS (adjusted odds ratio 1.3, 95% confidence interval 1.0-1.6) and a lower incidence of severe retinopathy of prematurity (adjusted odds ratio 0.5, 95% confidence interval 0.3-0.9) than did singletons.


CONCLUSIONS
Multiple-birth and singleton very preterm infants had similar outcomes, except for a higher incidence of RDS among multiple-birth infants.


METHODS
II.
Qiu
Xiangming
X
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Lee
Shoo K
SK
Tan
Kenneth
K
Piedboeuf
Bruno
B
Canning
Rody
R
D000328:Adult; D001034:Apgar Score; D002170:Canada / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development / Q000502:physiology*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development / Q000502:physiology*; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D016014:Linear Models; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology*; D012178:Retinopathy of Prematurity / Q000453:epidemiology; D018570:Risk Assessment