title: Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study.
abstract: The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of Sub-Group 3 (controls).
authors.affiliation: Oral Medicine, Valencia University, Department of Stomatology, University General Hospital, Valencia, Spain. bagan@uv.es
authors.forename: Jose V
authors.initials: JV
authors.lastname: Bagan
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jiménez
authors.forename: Judith
authors.initials: J
authors.lastname: Murillo
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda
authors.forename: José M
authors.initials: JM
authors.lastname: Díaz
authors.forename: Carmen
authors.initials: C
authors.lastname: Gavaldá
authors.forename: María
authors.initials: M
authors.lastname: Margaix
authors.forename: Crispian
authors.initials: C
authors.lastname: Scully
authors.forename: Trinidad M
authors.initials: TM
authors.lastname: Alberola
authors.forename: Manuela
authors.initials: M
authors.lastname: Torres Puente
authors.forename: Manuel
authors.initials: M
authors.lastname: Pérez Alonso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000821:virology*