title: Factors affecting heart rate as measured at home among treated hypertensive patients: the Japan home versus office blood pressure measurement evaluation (J-HOME) study.
abstract: We previously reported that a resting heart rate measured at home (home HR) of >or=70 beats per minute was a powerful predictor of the risk of cardiovascular disease mortality, and identified factors affecting home HR in the general Japanese population. The present study examines factors affecting home HR in hypertensive patients treated with antihypertensive medications. Home HR was measured using a home blood pressure (BP) device. Information about the characteristics of the patients was collected using questionnaires administered by a physician. Among 3,400 patients, 3,086 measured home HR both in the morning and evening. The mean values of home HR in the morning and evening were 67.2+/-9.1 and 69.6+/-9.2 beats per minute, respectively. Multivariate linear regression analysis showed that lower age, diabetes mellitus, habitual smoking, higher diastolic BP, and the lack of beta-blocker or angiotensin-converting enzyme inhibitor use were determinants of elevated morning or evening home HR. These results suggest that adequate control of risk factors for cardiovascular disease such as smoking and diabetes mellitus or use of heart rate-lowering agents might help to decrease home HR in treated hypertensive patients.
authors.affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Komai
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuya
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Inoue
authors.forename: Kei
authors.initials: K
authors.lastname: Asayama
authors.forename: Azusa
authors.initials: A
authors.lastname: Hara
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kenta
authors.initials: K
authors.lastname: Gonokami
authors.forename: Junichiro
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Totsune
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000959:Antihypertensive Agents / Q000494:pharmacology; D001795:Blood Pressure Determination; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents