[New methods in pharmaceutical research: combinatorial chemistry and high throughput screening].
New lead-identification methodologies such as high-throughput screening and combinatorial chemistry have been integrated into pharmaceutical research over the past 5-10 years. More rational use in the selection of potential preclinical candidates for some difficult targets has increased the chances of success.
Schirlin
Daniel
D
Sanofi-Aventis, Centre de recherche, 13 quai Jules Guesde, 94403 Vitry-sur-Seine.
Galvan
Martin
M
Le Fur
Gérard
G
D001331:Automation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004345:Drug Industry / Q000639:trends*; D006801:Humans; D008904:Miniaturization; D013678:Technology, Pharmaceutical / Q000639:trends*