[Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors].
Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
Yu
Ming-yan
MY
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
Liu
Xin-yong
XY
D019380:Anti-HIV Agents / Q000494:pharmacology; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D020672:I-kappa B Proteins / Q000378:metabolism; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D009539:Nicotinic Acids / Q000494:pharmacology; D009570:Nitriles / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects*; D014779:Virus Replication
C501280:2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile; D019380:Anti-HIV Agents; D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D009539:Nicotinic Acids; D009570:Nitriles; D000072000:NF-KappaB Inhibitor alpha; D051550:I-kappa B Kinase