Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp. (Tree1-7).
The metatrophic fungus Paecilomyces sp. (Tree1-7) was isolated from an estuarine mangrove from the Taiwan Strait. The methanol extract of the fungal mycelium exhibited cytotoxicity against hepG2. Paeciloxanthone (1), a new xanthone, and the known compounds emodin (2) and chrysophanol (3), were isolated from the extract. Their structures were elucidated by spectroscopic experiments. Paeciloxanthone (1) exhibited in vitro cytotoxicity against hepG2 (IC(50)=1.08 microg/mL), acetylcholineesterase (AChE) inhibitory (IC(50)=2.25 microg/mL) and antimicrobial activities.
Wen
Lu
L
School of Chemical and Chemical Engineering, and School of Pharmaceutical Science, Sun Yat-Sen (Zhongshan) University, Guangzhou, China.
Lin
Yong-Cheng
YC
She
Zhi-Gang
ZG
Du
Dun-Shuai
DS
Chan
Wing-Lai
WL
Zheng
Zhong-Hui
ZH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D010143:Paecilomyces / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; C531093:paeciloxanthone