title: Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in helix lucorum.
abstract: Injection of antibodies to Ca-binding protein S-100 in a dilution of 10(-12) before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization as a neurobiological model of anxiety and depression.
authors.affiliation: Materia Medica Company, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: M B
authors.initials: MB
authors.lastname: Stark
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Timoshenko
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gainutdinova
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001007:Anxiety / Q000276:immunology; D003863:Depression / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006372:Helix, Snails; D008954:Models, Biological; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D009418:S100 Proteins