title: Changes in two point discrimination and the law of mobility in diabetes mellitus patients.
abstract: BACKGROUND
  Diabetic neuropathy is a family of nerve disorders with progressive loss of nerve function in 15% of diabetes mellitus (DM) subjects. Two-point discrimination (TPD) is one method of quantitatively testing for loss of nerve function. The law of mobility for TPD is known for normal subjects in earlier studies but has not been studied for diabetic subjects. This is a pilot study to evaluate and plot the law of mobility for TPD among DM subjects.
  
  
  METHODS
  The Semmes Weinstein monofilament (SWMF) was used to measure the loss of protective sensation. An Aesthesiometer was used to find the TPD of several areas in upper and lower extremities for normal and diabetic subjects. All the subjects were screened for peripheral artery occlusive disease with ankle brachial pressure index (0.9 or above).
  
  
  RESULTS
  TPD of normal and diabetic subjects for different areas of hands and legs from proximal to distal is evaluated for 18 subjects. TPD values decrease from proximal to distal areas. Vierodt's law of mobility for TPD holds good for normal subjects in the hand and foot areas. The law of mobility for TPD in DM subjects holds well in the hand but doesn't hold well in foot areas with or without sensation.
  
  
  CONCLUSIONS
  TPD is a quantitative and direct measure of sensory loss. The TPD value of diabetic subjects reveals that the law of mobility do not hold well for Diabetic subjects in foot areas. The significance of this result is that the TPD of the diabetic subjects could provide direct, cost effective and quantitative measure of neuropathy.
authors.affiliation: Biomedical Engineering Group, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, 600036, India.
authors.forename: R
authors.initials: R
authors.lastname: Periyasamy
authors.affiliation: Biomedical Engineering Group, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, 600036, India.
authors.forename: M
authors.initials: M
authors.lastname: Manivannan
authors.affiliation: Diabetic Foot Clinic, Sundaram Medical Foundation, Chennai, 600040, India.
authors.forename: Vengesana Balakrish Raja
authors.initials: VBR
authors.lastname: Narayanamurthy