[Dose-effect relationship of para-toluenesulfonamide for treatment of hepatocellular carcinoma in rats].
OBJECTIVE
To investigate the dose-effect relationship of para-toluenesulfonamide (PTS) for treatment of hepatocellular carcinoma in rats.


METHODS
Forty-two SD rats bearing subcutaneous transplanted hepatocellular carcinoma were randomly divided into 6 groups (n=7), in which 0.02, 0.04, 0.06, 0.08, and 0.10 ml PTS and 0.10 ml normal saline were injected into the tumor, respectively. All of the rats were executed 24 h after the injection to observe the pathological changes in the tumor.


RESULTS
In rats with saline injection, the tumor tissues exhibited no obvious changes and the tumor cells retained the active proliferation. PTS, in contrast, caused coagulation necrosis of the tumor tissue, and the necrotic area expanded with the increase of the injected doses. The necrotic volume of the tumor was in roughly linear correlation with the dose of PTS injected, with the linear regression equation of V (cm(3))=-0.018+2.595Y (where V represents tumor necrosis volume, and Y the injected dose of PTS).


CONCLUSIONS
The dose-effect relationship of PTS is roughly linear, and the PTS dose for injection can be estimated according to the diameter of the tumor.
Li
Min-ying
MY
Oncology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. lmy69@163.com
Meng
Hui
H
Zhu
Wei-liang
WL
Zhou
Shao-zhang
SZ
Li
Hong-yi
HY
Zhang
Ji-ren
JR
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation; D004305:Dose-Response Relationship, Drug; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides / Q000627:therapeutic use*; D014050:Toluene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000096926:Benzenesulfonamides
D000970:Antineoplastic Agents; D013449:Sulfonamides; D014050:Toluene; C025417:4-toluenesulfonamide; D000096926:Benzenesulfonamides