title: Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths.
abstract: OBJECTIVE
  The purpose of this study was to determine factors responsible for the increasing number of deaths from corpus cancer over three time periods.
  
  
  METHODS
  Data were collected from the Surveillance, Epidemiology and End Results database from 1988-2001. Kaplan-Meier and Cox proportional hazards regression analyses were performed.
  
  
  RESULTS
  Of 48,510 women with corpus cancer, there was an increase in the proportion of patients dying from advanced cancers (52.1% to 56.0% to 68.8%; P < .001), grade 3 disease (47.5% to 53.3% to 60.6%; P < .001), serous tumors (14.3% to 18.4% to 16.6%; P < .001), and sarcomas (19.1% to 20.4% to 27.2%; P < .001) over time. On multivariate analysis, older age, African American race, lack of primary staging procedures, advanced-stage, high-grade, and non-endometrioid histology were independent prognostic factors for worse survival.
  
  
  CONCLUSIONS
  Our data suggest that the increase in mortality in women with corpus cancer over the last 14 years may be related to an increased rate of advanced-stage cancers and high-risk histologies.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, School of Medicine and Comprehensive Cancer Center, San Francisco, CA 94143-1702, USA.
authors.forename: Stefanie M
authors.initials: SM
authors.lastname: Ueda
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kapp
authors.forename: Michael K
authors.initials: MK
authors.lastname: Cheung
authors.forename: Jacob Y
authors.initials: JY
authors.lastname: Shin
authors.forename: Kathryn
authors.initials: K
authors.lastname: Osann
authors.forename: Amreen
authors.initials: A
authors.lastname: Husain
authors.forename: Nelson N
authors.initials: NN
authors.lastname: Teng
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Berek
authors.forename: John K
authors.initials: JK
authors.lastname: Chan
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D002291:Carcinoma, Papillary; D016208:Databases, Factual; D003710:Demography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009367:Neoplasm Staging; D012307:Risk Factors; D018426:SEER Program; D012509:Sarcoma / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality