title: Beta-carboline alkaloids from a Korean tunicate Eudistoma sp.
abstract: Seven new beta-carboline-based metabolites, designated as eudistomins Y1-Y7 ( 1- 7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the beta-carboline nucleus at C-1. Eudistomins Y 1-Y 7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 microM.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Korea.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Byoung-Chan
authors.initials: BC
authors.lastname: Lee
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002243:Carbolines; C528153:eudistomin Y6