Correction of morphological shifts in experimental syringomyelia.
The possibility of correcting morphological shifts in experimental syringomyelia with pyrimidine derivative hydroxymethyluracil (antioxidant with a wide spectrum of biological activities) was studied. Hydroxymethyluracil in a dose of 50 mg/kg prevented the development of morphological shifts characteristic of syringomyelia in the CNS of laboratory animals. Hydroxymethyluracil prevented the development of neurological symptoms and trophic disorders of the skin in rabbits with syringomyelia.
Mirsaev
T R
TR
Bashkir State Medical University, Ufa, Russia. mirsaev@mail.ru
D000818:Animals; D004195:Disease Models, Animal; D010432:Pentoxyl / Q000031:analogs & derivatives / Q000627:therapeutic use; D011817:Rabbits; D013595:Syringomyelia / Q000188:drug therapy / Q000473:pathology*
C008055:5-hydroxymethyluracil; D010432:Pentoxyl