[Polymeric drug carriers activated by ultrasounds energy].
In the last two decades an extensive research on the employment of ultrasounds in anticancer therapy has been noticed. So far ultrasounds have been widely used in medicine for diagnostic purposes (ultrasonography), but their great therapeutic potential and the development of polymer based antineoplastic drug carriers have persuaded many investigators to start research on the employment of ultrasounds in anticancer therapy. A new therapeutic concept based on the controlled drug's molecules release from their transporting polymer carriers has been proposed. Cavitation, a phenomenon characteristic for the action of ultrasounds, is used to destroy polymeric drug carriers and for drug release in target sites. The sonodynamic therapy (SDT) which utilizes ultrasonic waves for "acoustic drug activation" leading to the enhancement of cytotoxic activity of some drugs has also been developed. Furthermore, a long standing research on ultrasounds resulted in a new concept based on hyperthermia. This method of cancer treatment does not require any chemotherapeutic agent to be applied.
Kik
Krzysztof
K
Katedra Chemii Biomedycznej, Zaklad Farmakologii Molekularnej, Uniwersytetu Medycznego w Lodzi. chemgen@csk.umed.lodz.pl
Lwow
Felicja
F
Szmigiero
Leszek
L
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D001672:Biocompatible Materials; D006224:Cricetinae; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008081:Liposomes; D051379:Mice; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy; D020442:Poloxamer / Q000737:chemistry*; D051381:Rats; D014465:Ultrasonics
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D008081:Liposomes; D008823:Micelles; D020442:Poloxamer; D004317:Doxorubicin