title: Malaria in central Vietnam: analysis of risk factors by multivariate analysis and classification tree models.
abstract: BACKGROUND
  In Central Vietnam, forest malaria remains difficult to control due to the complex interactions between human, vector and environmental factors.
  
  
  METHODS
  Prior to a community-based intervention to assess the efficacy of long-lasting insecticidal hammocks, a complete census (18,646 individuals) and a baseline cross-sectional survey for determining malaria prevalence and related risk factors were carried out. Multivariate analysis using survey logistic regression was combined to a classification tree model (CART) to better define the relative importance and inter-relations between the different risk factors.
  
  
  RESULTS
  The study population was mostly from the Ra-glai ethnic group (88%), with both low education and socio-economic status and engaged mainly in forest activities (58%). The multivariate analysis confirmed forest activity, bed net use, ethnicity, age and education as risk factors for malaria infections, but could not handle multiple interactions. The CART analysis showed that the most important risk factor for malaria was the wealth category, the wealthiest group being much less infected (8.9%) than the lower and medium wealth category (16.6%). In the former, forest activity and bed net use were the most determinant risk factors for malaria, while in the lower and medium wealth category, insecticide treated nets were most important, although the latter were less protective among Ra-glai people.
  
  
  CONCLUSIONS
  The combination of CART and multivariate analysis constitute a novel analytical approach, providing an accurate and dynamic picture of the main risk factors for malaria infection. Results show that the control of forest malaria remains an extremely complex task that has to address poverty-related risk factors such as education, ethnicity and housing conditions.
authors.affiliation: National Institute of Malariology, Parasitology and Entomology, Luong The Vinh street, BC 10200 Tu Liem district, Hanoi, Vietnam. thangnimpevn@yahoo.com
authors.forename: Ngo Duc
authors.initials: ND
authors.lastname: Thang
authors.forename: Annette
authors.initials: A
authors.lastname: Erhart
authors.forename: Niko
authors.initials: N
authors.lastname: Speybroeck
authors.forename: Le Xuan
authors.initials: le X
authors.lastname: Hung
authors.forename: Le Khanh
authors.initials: le K
authors.lastname: Thuan
authors.forename: Cong Trinh
authors.initials: CT
authors.lastname: Hung
authors.forename: Pham Van
authors.initials: PV
authors.lastname: Ky
authors.forename: Marc
authors.initials: M
authors.lastname: Coosemans
authors.forename: Umberto
authors.initials: U
authors.lastname: D'Alessandro
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001513:Beds / Q000592:standards*; D002648:Child; D003430:Cross-Sectional Studies; D003663:Decision Trees; D005006:Ethnicity; D005260:Female; D006801:Humans; D007303:Insect Vectors; D007306:Insecticides; D016015:Logistic Models; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016273:Occupational Exposure; D011203:Poverty; D015995:Prevalence; D014197:Trees; D014744:Vietnam / Q000453:epidemiology
chemical_list: D007306:Insecticides