Palladium-catalyzed intramolecular chloroamination of alkenes.
A mild and facile Pd-catalyzed intramolecular chloroamination of unactivated alkenes has been described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. Generally high exo-selectivities are observed in the formation of a variety of 5- and 6-membered rings. This system is unique in its ability to tolerate multidentate ligands on palladium, which opens up the possibility of controlling the absolute sense of induction using a chiral ligand.
Michael
Forrest E
FE
Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA. michael@chem.washington.edu
Sibbald
Paul A
PA
Cochran
Brian M
BM