Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga.
Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.
Alekseyenko
T V
TV
Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Zhanayeva
S Ya
SY
Venediktova
A A
AA
Zvyagintseva
T N
TN
Kuznetsova
T A
TA
Besednova
N N
NN
Korolenko
T A
TA
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002401:Cathepsin B / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000378:metabolism; D003520:Cyclophosphamide / Q000627:therapeutic use; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004357:Drug Synergism; D044645:Fucus / Q000737:chemistry; D008175:Lung Neoplasms / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology; D011134:Polysaccharides / Q000627:therapeutic use*; D013463:Sulfuric Acid Esters / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides; D013463:Sulfuric Acid Esters; D003520:Cyclophosphamide; C007789:fucoidan; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534278:Ctsl protein, mouse; D002402:Cathepsin D