[Serotonin syndrome as a result of escitalopram and cyclosporin combination in an 84-year-old woman].
Due to the stimulation of central and peripheral 5-hydroxytryptamine receptors, the serotonin syndrome is a potentially lethal situation. The large variety of its clinical manifestations leads to a difficult diagnosis. We describe the case of a serotonin syndrome induced by the combined escitalopram and cyclosporine administration. An 84-year-old woman was hospitalized with a history of delirium associated with hyperthermia. The diagnosis of serotonin syndrome was suspected with the combination of the clinical features: the absence of infection, the selective serotonin reuptake inhibitor administration, and the absence of other metabolic and cerebral aetiology. After the discontinuation of escitalopram, the patient's condition improved rapidly. This report is a reminder of the clinical and pharmacological features of the serotonin syndrome from a recent literature review.
Lang
P-O
PO
Service de médecine interne et réadaptation, département de réhabilitation et gériatrie, hôpital des Trois-Chêne, hôpitaux universitaires de Genève, 3, chemin du Pont-Bochet, 1226 Thônex, Suisse. Pierre.O.Lang@hcuge.ch
Hasso
Y
Y
Hilleret
H
H
Vogt-Ferrier
N
N
D000369:Aged, 80 and over; D015283:Citalopram / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D003693:Delirium / Q000139:chemically induced; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D016896:Treatment Outcome
D015283:Citalopram; D016572:Cyclosporine; D007166:Immunosuppressive Agents; D017367:Selective Serotonin Reuptake Inhibitors