title: Beyond chemotherapy--demystifying the new 'targeted' cancer treatments.
abstract: It has been known for some time that key genetic changes are the principle mechanism of cancer development. These changes lead to abnormalities in the signalling pathways of cells and result in unregulated cell growth, angiogenesis and metastasis.
authors.affiliation: Medical Oncology, Westmead and Nepean Hospitals, New South Wales. rachshaw@hotmail.com
authors.forename: Rachel
authors.initials: R
authors.lastname: Dear
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wilcken
authors.forename: Jenny
authors.initials: J
authors.lastname: Shannon
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001549:Benzamides; D004347:Drug Interactions; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D000068877:Imatinib Mesylate; D008967:Molecular Biology / Q000639:trends*; D009369:Neoplasms / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor; D000068878:Trastuzumab