title: Integration of signals mediated by B-cell receptor, B-cell activating factor of the tumor necrosis factor family (BAFF) and Fas (CD95).
abstract: The survival of the mature resting B cells depends on signaling from B cell receptor (BCR), and a plethora of positive and negative regulators, that maintain cellular homeostasis and ultimately determine cell's fate, i.e., survival or programmed death (apoptosis). Among these regulators we have investigated the B cell activating factor belonging to tumor necrosis factor family (BAFF) and the prototypic death receptor Fas/CD95 mediated signals. We have shown that BAFF inhibits Fas-mediated cell death, however, the BCR-driven survival signals were not strengthened by BAFF. Therefore, we propose that BAFF may function independently of the antigen specificity of BCR, thus may enhance the risk of autoimmune diseases by promoting the survival of bystander B cells in the germinal center.
authors.affiliation: Department of Immunology, Eötvös Loránd University, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Hancz
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hérincs
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Neer
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sármay
authors.forename: Gábor
authors.initials: G
authors.lastname: Koncz
mesh_terms: D017209:Apoptosis / Q000276:immunology; D053264:B-Cell Activating Factor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism*
chemical_list: D053264:B-Cell Activating Factor; D011947:Receptors, Antigen, B-Cell; C505719:TNFSF13B protein, human; D019014:fas Receptor