Solid-phase parallel synthesis of phosphite ligands.
Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.
Swennenhuis
Bert H G
BH
Van 't Hoff Institute of Molecular Sciences, University of Amsterdam, The Netherlands.
Chen
Ruifang
R
van Leeuwen
Piet W N M
PW
de Vries
Johannes G
JG
Kamer
Paul C J
PC
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D008024:Ligands; D009943:Organophosphorus Compounds; D017905:Phosphites; C434331:phosphoramidite