title: Variations in the content of some trace elements and macroelements in the hippocampus of rats during learning and memory retrieval after destruction of the entorhinal cortex.
abstract: We studied variations in the concentration of Na, K, Ca, and Mg in the hippocampus of rats with damaged entorhinal cortex. The concentration of Mg, Na, K, and Ca remained practically unchanged, while the content of Zn and Cu increased during learning and memory retrieval in animals with damaged entorhinal cortex. Our results indicate that Zn and Cu, constituents of metalloproteins and metalloenzymes, play an important role in hippocampal function.
authors.affiliation: I. S. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi.
authors.forename: Ts V
authors.initials: TsV
authors.lastname: Gigineishvili
authors.forename: L G
authors.initials: LG
authors.lastname: Gegenava
authors.forename: N A
authors.initials: NA
authors.lastname: Machavariani
authors.forename: N M
authors.initials: NM
authors.lastname: Magradze
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D018728:Entorhinal Cortex / Q000502:physiology*; D006624:Hippocampus / Q000737:chemistry*; D007858:Learning / Q000502:physiology*; D008274:Magnesium / Q000378:metabolism; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D014131:Trace Elements; D003300:Copper; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium