Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents.
In the course of our studies on the isolation of bioactive compounds from the roots of Moringa oleifera, a traditional herb in southeast Asia, rare aurantiamide acetate 4 and 1,3-dibenzyl urea 5 have been isolated and characterized. And also, this is the first report of isolation from this genus. Isolated compound inhibited the production of TNF-alpha and IL-2; further compound 5 showed significant analgesic activities in a dose dependant manner. These findings may help in understanding the mechanism of action of this traditional plant leading to control of activated mast cells on inflammatory conditions like arthritis, for which the crude extract has been used.
Sashidhara
Koneni V
KV
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India. sashidhar123@gmail.com
Rosaiah
Jammikuntla N
JN
Tyagi
Ethika
E
Shukla
Rakesh
R
Raghubir
Ram
R
Rajendran
Siron M
SM
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D008407:Mast Cells / Q000187:drug effects; D029588:Moringa oleifera / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004151:Dipeptides; D007376:Interleukin-2; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D014508:Urea