title: Transkarbams with terminal branching as transdermal permeation enhancers.
abstract: Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
authors.affiliation: Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 50005, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Klimentová
authors.forename: Petr
authors.initials: P
authors.lastname: Kosák
authors.forename: Katerina
authors.initials: K
authors.lastname: Vávrová
authors.forename: Tomás
authors.initials: T
authors.lastname: Holas
authors.forename: Jakub
authors.initials: J
authors.lastname: Novotný
authors.forename: Alexandr
authors.initials: A
authors.lastname: Hrabálek
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002219:Carbamates / Q000737:chemistry* / Q000493:pharmacokinetics*; D010539:Permeability; D012867:Skin; D012869:Skin Absorption / Q000187:drug effects*; D013552:Swine; D013806:Theophylline / Q000008:administration & dosage
chemical_list: D002219:Carbamates; D013806:Theophylline