title: Anchoring the genome.
abstract: Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.
authors.affiliation: Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK.
authors.forename: Diego
authors.initials: D
authors.lastname: Ottaviani
authors.forename: Elliott
authors.initials: E
authors.lastname: Lever
authors.forename: Petros
authors.initials: P
authors.lastname: Takousis
authors.forename: Denise
authors.initials: D
authors.lastname: Sheer
mesh_terms: D001665:Binding Sites; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D005786:Gene Expression Regulation; D016678:Genome; D015530:Nuclear Matrix / Q000378:metabolism*
chemical_list: D004247:DNA