title: [Preparation and in vitro dissolution of the solid dispersions of cinnamon oil].
abstract: OBJECTIVE
  To prepare sustained-release capsules of cinnamon oil with stearic acid, polyethylene glycol 6000 and gluceryl monostearate.
  
  
  METHODS
  After the solid dispersion of cinnamon oil was prepared by melting method, the effects of the process variables and formulation variables on solid dispersion and dissolution were investigated. The formulation and preparation process of cinnamon oil solid dispersion were optimized by orthogonal design, and Fourier-transformed infrared (FTIR) spectroscopy was employed to detect the possible molecular interaction between cinnamon oil and the adjuvants.
  
  
  RESULTS
  The in vitro release percentage of the optimized formula complied with the Higuchi equation, and the preparation allowed drug delivery for 12 h. Analysis with FTIR spectroscopy revealed interactions between cinnamon oil and the adjuvents and formation of the solid dispersion.
  
  
  CONCLUSIONS
  The solid dispersion capsules prepared through this simple and well reproducible process allow obviously sustained release of cinnamon oil.
authors.affiliation: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. yaolin526@126.com
authors.forename: Lin
authors.initials: L
authors.lastname: Yao
authors.forename: Kang-Yin
authors.initials: KY
authors.lastname: Deng
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Luo
mesh_terms: D002214:Capsules; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics; D009822:Oils, Volatile / Q000737:chemistry* / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile