Salvage radiotherapy for patients with PSA relapse after radical prostatectomy: a single institution experience.
BACKGROUND
To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT.


METHODS
Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patients received a median of 66 Gy to the prostate bed with 3D or 2D RT. The main end point was biochemical failure after salvage RT, defined as an increase of the serum PSA value >0.2 ng/ml confirmed by a second elevation.


RESULTS
Median follow-up was 38 months. The 3-year and 5-year bDFS rates were 56.1% and 41.2% respectively. According to multivariate analysis, only preRT PSA > or =1 ng/ml was associated with biochemical relapse.


CONCLUSIONS
When delivered early, RT is an effective treatment after radical prostatectomy. Only preRT PSA > or =1 ng/ml predicted relapse.
Quero
Laurent
L
Department of Radiation Oncology, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France. laurent.quero@wanadoo.fr
Mongiat-Artus
Pierre
P
Ravery
Vincent
V
Maylin
Claude
C
Desgrandchamps
François
F
Hennequin
Christophe
C
D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000639:trends; D011471:Prostatic Neoplasms / Q000097:blood* / Q000532:radiotherapy* / Q000601:surgery; D016879:Salvage Therapy / Q000379:methods*; D055502:Secondary Prevention; D015996:Survival Rate / Q000639:trends
D017430:Prostate-Specific Antigen