[The legacy of Andrey Mirzabekov and his laboratory in the studies of chromatin structure using DNA-protein cross-linking].
The work of A.D. Mirzabekov and his collaborators on chromatin structure is reviewed. The methods of DNA-protein covalent binding with subsequent analysis of cross-linked products developed in the laboratory were used to localize the contacts in both DNA and individual proteins. This original approach played an important role in the deciphering of the molecular structure of nucleosome. In addition, it made possible the investigation of structural transitions in chromatin upon gene activation.
Preobrazhenskaia
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OV
Karpov
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Kolchinskiĭ
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D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000266:history; D004247:DNA / Q000737:chemistry / Q000266:history / Q000378:metabolism*; D049673:History, 20th Century; D009687:Nuclear Proteins / Q000737:chemistry / Q000266:history / Q000378:metabolism*; D009707:Nucleosomes / Q000737:chemistry / Q000378:metabolism*
D003432:Cross-Linking Reagents; D009687:Nuclear Proteins; D009707:Nucleosomes; D004247:DNA