Deciphering histone 2A deubiquitination.
Three recent papers have identified distinct enzymes that can remove ubiquitin from mammalian histone 2A (H2A). Functions in transcriptional activation, DNA repair and control of the cell cycle have been proposed for these enzymes.
Clague
Michael J
MJ
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK. clague@liv.ac.uk
Coulson
Judy M
JM
Urbé
Sylvie
S
D000818:Animals; D002453:Cell Cycle; D004260:DNA Repair; D004798:Enzymes / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D015533:Transcriptional Activation; D054875:Ubiquitination / Q000502:physiology*
D004798:Enzymes; D006657:Histones