[Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp].
OBJECTIVE
To study the effect of IgE, GM-CSF on eosinophil accumulation in the nasal polyps and find the relationship between them.


METHODS
Thirty mucosa constitution samples of nasal polyps and eleven inferior nasal concha were observed. The distribution of IgE was detected by SP immunohistochemical method, while the concentration of GM-CSF was measured by ELISA technique and the number of eosinophils were counted in the same tissues.


RESULTS
The level of IgE, GM-CSF and eosinophils had significant different between the nasal polyps and control group (P < 0.01). There was positive correlation between IgE/GM-CSF and the number of eosinophils in the nasal polyps group (r = 0.65, 0.62, P < 0.01). The correlation between concentration of IgE and GM-CSF was also significant in nasal polyps group (r = 0.52, P < 0.01).


CONCLUSIONS
Nasal polyps is characterized by eosinophil accumulation. IgE and GM-CSF may contribute to the recruitment of eosinophils in nasal polyps. Type-I allergy mediated by IgE play an important role in the pathogenesis of nasal polyps.
Tian
Congzhe
C
Department of Otolaryngology, Affiliated Hospital of Hebei University, Baoding, 071000, China. yongyong5752@vip.sina.com
Tan
Yanli
Y
Gao
Yongping
Y
Du
Jinduo
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
D007073:Immunoglobulin E; D016178:Granulocyte-Macrophage Colony-Stimulating Factor