DJ-1 is essential for long-term depression at hippocampal CA1 synapses.
Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.
Wang
Yue
Y
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. wangyu@grc.nia.nih.gov
Chandran
Jayanth S
JS
Cai
Huaibin
H
Mattson
Mark P
MP
D000818:Animals; D065127:Dopamine D2 Receptor Antagonists; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D015513:Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D054464:Peroxiredoxins; D000071617:Protein Deglycase DJ-1; D019257:Quinpirole / Q000494:pharmacology; D050637:Receptors, Dopamine D3 / Q000187:drug effects; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
C493593:DRD3 protein, human; D065127:Dopamine D2 Receptor Antagonists; D015513:Oncogene Proteins; D050637:Receptors, Dopamine D3; D019257:Quinpirole; D054464:Peroxiredoxins; C503466:PARK7 protein, mouse; D000071617:Protein Deglycase DJ-1