title: Hepatocellular carcinoma in Port Harcourt, Nigeria: clinicopathologic study of 75 cases.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is a complication of liver cirrhosis caused by hepatitis B viral infection, fungal infection and genetic factors. This disease though having a silent course is associated with variable morbidity and mortality in this environment.
  
  
  METHODS
  Previously prepared histologic slides were retrieved and re-evaluated to confirm the diagnosis. Clinical data such as the age, sex, clinical presentations, histologic grading and cause of death were extracted from the case notes, histology request forms and autopsy protocol forms.
  
  
  RESULTS
  Seventy five cases were used for the study during the period under review. The youngest was a 14 year old male while the oldest was a 66 years old male. Male to female ratio was 2:1. Majority (28%) occurred in the age group 40-49 years. Upper abdominal mass was the most common clinical presentation (30.7%) and well differentiated hepatocellular carcinoma was the most common (64.0%) histologic grade. Trabecular inusoidal pattern (49.3%) was the most common histologic type (pattern) while upper gastro-intestinal bleeding (38.7%) was the most common cause of death at autopsy.
  
  
  CONCLUSIONS
  Hepatocellular carcinoma is a notable malignancy of the liver associated with variable morbidities and mortality as it has an insidious onset and very aggressive course.
authors.affiliation: Department of Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. dsfubara@yahoo.com
authors.forename: D
authors.initials: D
authors.lastname: Seleye-Fubara
authors.forename: N J
authors.initials: NJ
authors.lastname: Jebbin
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications; D009549:Nigeria; D012189:Retrospective Studies; D012307:Risk Factors