title: Successful renal transplantation in children in the presence of thrombosis of the inferior vena cava.
abstract: Thrombosis of the inferior vena cava (IVC) has previously been considered to be a contraindication to renal transplantation in children because of the technical difficulties associated with surgery and the increased risk of graft thrombosis. We report three children with previous IVC thrombosis who underwent renal transplantation at our institution over the last 5 years. The pretransplant imaging of these patients included direct venography or magnetic resonance venography to evaluate venous outflow. Two children (19 kg and 36 kg) received deceased donor renal allografts with no surgical complications or delayed graft function. At the latest follow-up 3.0 and 4.6 years posttransplantation, respectively, they were well, with estimated glomerular filtration rates of 52 and 64 ml/min per 1.73 m(2), respectively. The third child underwent a live-related-donor renal transplant at the age of 4.9 years (weight 13.5 kg). There was primary graft nonfunction. Renal vein thrombosis was noted on postoperative day 12, with subsequent graft loss. Children with previous IVC thrombosis can be successfully transplanted with adult-sized kidneys provided detailed evaluation of the venous drainage has been performed. There is substantial risk of graft thrombosis, and detailed counselling regarding the specific risks of the procedure is essential.
authors.affiliation: Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, M27 4HA, UK.
authors.forename: Mohan
authors.initials: M
authors.lastname: Shenoy
authors.forename: Ravi
authors.initials: R
authors.lastname: Pararajasingam
authors.forename: Neville B
authors.initials: NB
authors.lastname: Wright
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Lewis
authors.forename: Neil
authors.initials: N
authors.lastname: Parrott
authors.forename: Hany
authors.initials: H
authors.lastname: Riad
authors.forename: Nicholas J A
authors.initials: NJ
authors.lastname: Webb
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D009929:Organ Size; D010690:Phlebography; D012039:Regional Blood Flow / Q000502:physiology; D014019:Tissue Donors; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000503:physiopathology*; D020246:Venous Thrombosis / Q000150:complications* / Q000503:physiopathology; D055815:Young Adult