title: The use of phosphine ligands to control the regiochemistry of Pd-catalyzed hydrostannations of 1-alkynes: synthesis of (E)-1-tributylstannyl-1-alkenes.
abstract: The regiochemistry of palladium-catalyzed hydrostannations of terminal alkynes is dramatically influenced by ligand effects. Use of phosphines such as Cy3P, t-Bu2PCH2t-Bu, and t-Bu3P provides (E)-1-tributylstannyl-1-alkenes with regioselectivities up to >99:<1 for substrates where the commonly used Ph3P shows much lower regioselectivities.
authors.affiliation: Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry (GWC)2, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Alla
authors.initials: A
authors.lastname: Darwish
authors.forename: Adam
authors.initials: A
authors.lastname: Lang
authors.forename: Thomas
authors.initials: T
authors.lastname: Kim
authors.forename: J Michael
authors.initials: JM
authors.lastname: Chong