Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III.
Elastic fibers appear in extensive old fibrotic foci in general. We examined an association between hepatic fibrosis stage and the presence of perivenular elastic fibers in nonalcoholic steatohepatitis (NASH). A total of 48 liver needle biopsy specimens were used, taken from 48 cases with NASH. Fibrosis Stage (Brunt E, et al. Am. J. Gastroenterol. 1999) of the cases was as follows; six Fibrosis Stage I, twenty-two Fibrosis Stage II, and twenty Fibrosis Stage III. We examined Orcein stain sections in all of the liver needle biopsy specimens. In all twenty Fibrosis Stage III cases, perivenular elastic fiber bundles were observed. In contrast, perivenular elastic fibers were detected only in one of the six Fibrosis Stage I and two of the twenty-two Fibrosis Stage II cases. In liver needle biopsy specimens of NASH, detection of perivenular elastic fibers is useful in deciding Fibrosis Stage III.
Nakayama
H
H
Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan. nakayamh@hiroshima-u.ac.jp
Itoh
H
H
Kunita
S
S
Kuroda
N
N
Hiroi
M
M
Matsuura
H
H
Yasui
W
W
Enzan
H
H
D001707:Biopsy, Needle; D018450:Disease Progression; D004547:Elastic Tissue / Q000378:metabolism*; D005234:Fatty Liver / Q000473:pathology* / Q000601:surgery; D005355:Fibrosis; D006651:Histocytochemistry; D006801:Humans; D013223:Statistics as Topic; D014699:Venules / Q000378:metabolism*