title: Indications and donor selections for allogeneic stem cell transplantation in children with hematologic malignancies.
abstract: Allogeneic stem cell transplantation (SCT) is the only curative approach for many patients with advanced or high-risk leukemia. Advances in supportive care and management of graft-versus-host disease have resulted in improvements in outcomes of related and unrelated donor SCT, creating controversies as to which strategy might be the optimal therapy for individual patients. This article discusses the indications and donor selection strategies for SCT in patients with malignant hematologic disease.
authors.affiliation: Department of Hematology/Oncology and General Pediatrics, Children's University Hospital, Hoppe-Seyler-Strasse 1, Tuebingen, Germany. rupert.handgretinger@med.uni-tuebingen.de
authors.forename: Rupert
authors.initials: R
authors.lastname: Handgretinger
authors.forename: Joanne
authors.initials: J
authors.lastname: Kurtzberg
authors.forename: R Maarten
authors.initials: RM
authors.lastname: Egeler
mesh_terms: D002648:Child; D006085:Graft Survival / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000379:methods; D014181:Transplantation Immunology / Q000276:immunology; D014184:Transplantation, Homologous