title: Late relapse of herpes simplex virus encephalitis in a child due to reactivation of latent virus: clinicopathological report and review.
abstract: A child suffered from herpes simplex virus encephalitis at the age of 6 months; a late relapse occurred 8.5 years after the initial episode, the longest latency period reported. Radiologic and autopsy findings suggest local reactivation of latent herpes simplex virus as the cause of relapse. All cases of late relapse of herpes simplex virus encephalitis in the last 15 years are reviewed, with emphasis on clinical characteristics and possible mechanisms.
authors.affiliation: Pediatric Department A, Ha Emek Medical Center, Afula. Israel. spiegelr@zahav.net.il
authors.forename: Ronen
authors.initials: R
authors.lastname: Spiegel
authors.forename: Dan
authors.initials: D
authors.lastname: Miron
authors.forename: Helena
authors.initials: H
authors.lastname: Yodko
authors.forename: Dmitry
authors.initials: D
authors.lastname: Lumelsky
authors.forename: Adib
authors.initials: A
authors.lastname: Habib
authors.forename: Yoseph
authors.initials: Y
authors.lastname: Horovitz
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D020803:Encephalitis, Herpes Simplex; D017809:Fatal Outcome; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D014775:Virus Activation; D017735:Virus Latency
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir