title: Classifying the expansion kinetics and critical surface dynamics of growing cell populations.
abstract: We systematically study the growth kinetics and the critical surface dynamics of cell monolayers by a class of computationally efficient cellular automaton models avoiding lattice artifacts. Our numerically derived front velocity relationship indicates the limitations of the Fisher-Kolmogorov-Petrovskii-Piskounov equation for tumor growth simulations. The critical surface dynamics corresponds to the Kardar-Parisi-Zhang universality class, which disagrees with the interpretation by Bru et al. of their experimental observations as generic molecular-beam-epitaxy-like growth, questioning their conjecture that a successful therapy should lead away from molecular beam epitaxy.
authors.affiliation: Institut für Theoretische Physik, Technische Universität Berlin, 10623 Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Block
authors.forename: E
authors.initials: E
authors.lastname: Schöll
authors.forename: D
authors.initials: D
authors.lastname: Drasdo
mesh_terms: D017209:Apoptosis; D002448:Cell Adhesion; D002450:Cell Communication; D002453:Cell Cycle; D048708:Cell Growth Processes; D002465:Cell Movement; D008954:Models, Biological