title: A notch sweeter.
abstract: Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.
authors.affiliation: Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA. irvine@waksman.rutgers.edu
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Irvine
mesh_terms: D000483:Alleles; D000818:Animals; D002384:Catalysis; D004330:Drosophila / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins; D017353:Gene Deletion; D005786:Gene Expression Regulation; D017344:Genes, Insect; D005820:Genetic Testing; D005947:Glucose / Q000378:metabolism; D005964:Glucosyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006031:Glycosylation; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D015398:Signal Transduction; D013696:Temperature
chemical_list: D029721:Drosophila Proteins; D051880:Receptors, Notch; D012694:Serine; D005964:Glucosyltransferases; D005947:Glucose