title: Mechanisms of defense formation against meningococcal infection in mice immunized with synthetic peptides.
abstract: Immunization of mice with synthetic peptide fragments of conservative sites of meningococcal outer membrane proteins led to defense formation against infection with virulent serogroup A and B Meningococci. The role of cellular immunity in the formation of defense against meningococcal infection after immunization with the peptides and the possibility of stimulating lymphocyte population with these peptides were demonstrated.
authors.affiliation: M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
authors.forename: O V
authors.initials: OV
authors.lastname: Chibiskova
authors.forename: O V
authors.initials: OV
authors.lastname: Kotel'nikova
authors.forename: V A
authors.initials: VA
authors.lastname: Nesmeyanov
authors.forename: A P
authors.initials: AP
authors.lastname: Alliluev
authors.forename: O M
authors.initials: OM
authors.lastname: Vol'pina
authors.forename: D O
authors.initials: DO
authors.lastname: Koroev
authors.forename: M P
authors.initials: MP
authors.lastname: Filatova
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D017710:Lymphocyte Transfusion; D008589:Meningococcal Infections / Q000517:prevention & control*; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology / Q000637:transplantation; D013997:Time Factors
chemical_list: D001425:Bacterial Outer Membrane Proteins; D010446:Peptide Fragments